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AIDS Research and Treatment
AIDS Research and Treatment / 2011 / Article
AbstractIntroductionMethodsResultsDiscussionConclusionAcknowledgmentsReferencesCopyright
Antiretroviral Treatment in Resource-Limited Settings
Research Article | Open Access
Volume 2011 |Article ID 769627 | https://doi.org/10.1155/2011/769627
Carole L. Wallis, John W. Mellors, Willem D. F. Venter, Ian Sanne, Wendy Stevens, "Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa", AIDS Research and Treatment, vol. 2011, Article ID 769627, 5 pages, 2011. https://doi.org/10.1155/2011/769627
Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa
Carole L. Wallis,1 John W. Mellors,2 Willem D. F. Venter,3 Ian Sanne,4 and Wendy Stevens1,5
1Department of Molecular Medicine & Hematology , University of the Witwatersrand, Wits Medical School, 3B22, 3rd Floor, 7 York Road, Parktown 2193, South Africa
2Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, USA
3 Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
4Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
5National Health Laboratory Services (NHLS), Johannesburg, South Africa
Academic Editor: Esper Kallas
Received16 May 2010
Accepted27 Oct 2010
Published02 Dec 2010
Limited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure. This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir. Ninety six percent of patients ( ) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D and one with HIV-1 subtype A1. Thirty nine percent ( ) of patients had no resistance mutations in protease or reverse transcriptase suggesting that medication non-adherence was a major factor contributing to failure. Major lopinavir resistance mutations were infrequent (5 of 75; 7%), indicating that drug resistance is not the main barrier to future viral suppression.
The South African antiretroviral roll out programme consists of a non-nucleoside reverse transcriptase inhibitor (NNRTI) based first-line regimen and a ritonavir-boosted protease inhibitor (PI) containing second-line regimen. Standard genotype analyses of first-line failure samples from South Africa have shown that the majority of patients remain susceptible to the second-line regimen of zidovudine (AZT), didanosine (ddI), and lopinavir/ritonavir (LPV/r) [1–3]. With over one million patients on antitretroviral therapy (ART) in the South African programme, a rise in second-line regimen failures is expected. Currently, little is known about treatment options after second-line failure or the frequency of protease inhibitor resistance in HIV-1 subtype C.
Patients with HIV-1 subtype B who experience virologic failure on an initial regimen containing LPV/r infrequently have major protease (PR) mutations detected [4]. Resistance to LPV generally requires the accumulation of several mutations in the PR gene although rare, single mutations can reduce susceptibility [5, 6]. Several studies have identified naturally occurring polymorphisms in subtype C PR that may facilitate the development of PI resistance, but their clinical significance is uncertain [7, 8]. The current study assessed the occurrence of known HIV-1 drug-resistance mutations in PR and RT in patients with second-line ART failure and the remaining treatment options.
2. Methods
2.1. Patient Samples
Plasma samples from 75 patients on a failing second-line regimen (LPV/r and 2 NRTI) were sent for HIV-1 drug-resistance testing from clinics at two large state hospitals in Johannesburg, South Africa. Virologic failure was defined as having confirmed (two consecutive measurements) of plasma HIV-1 RNA greater than 5000 copies/mL. Because pretherapy samples were not available from these patients, PR sequences were compared with those from 226 LPV/r naïve patients on failing first-line ART from the same two clinics [1]. The work conducted on these samples was with the understanding and the consent of the human subjects.
2.2. Population Genotype Analysis
Population-based genotyping was performed using an in-house drug-resistance assay. Briefly, a 1.7 kb amplicon was generated by RT-initiated polymerase chain reaction encompassing the entire PR and partial RT-coding regions. The amplicon was sequenced using five primers that ensure bidirectional coverage from codons 1–99 of PR and codons 1–230 of RT. Sequencing was performed with either an ABI Prisms 3730 or an ABI Prism 3100-Avant Genetic Analyzer (Applied Biosystems, USA).
2.3. Data and Statistical Analyses
Sequences were assembled, manually edited using Sequencher v4.5 software (Gene codes, Ann Arbor, MI), and submitted to the ViroScore database, which uses the IAS-USA mutation list to identify HIV-1 drug resistance mutations (http://www.iasusa.org/). The frequency distribution of PR mutations was also compared in LPV/r-naïve and -exposed patients. The REGA HIV-1 subtyping tool was used to determine HIV-1 subtype of each patient sample (http://www.bioafrica.net/subtypetool/html). The chi-squared test was used to determine if the frequency of naturally occurring polymorphisms in LPV/r-naive and -exposed patients differed significantly. A -value of <.01 was considered significant to adjust for the multiple comparisons across PR.
A total of 75 plasma samples were available from patients experiencing virologic failure on a second-line LPV/r-based regimen (Table 1). The mean age was 34 years (IQR 29–40), 69% were female ( ), and the average time on second-line therapy was 16 months (range 4–54 months; Table 1). At the time of failure, median CD4+ T-cell count and mean HIV-1 RNA were 141 cells/mm3 and 184,779 copies/mL, respectively. There was no difference in HIV-1 RNA or CD4 levels observed in patients with and without PI mutations ( and , resp.).
Variable Median (inter quartile range)
Median (inter quartile range) No PI major mutations ( 𝑛 = 7 0 ) PI major mutations ( 𝑛 = 5 )
Age (years) 34 (29–40)
CD4+ T-cells/mm3 141 (75–245) 138 (80–229) 246 (194–254)
HIV-1 RNA (copies/mL) 184,779 (8790–166,300) 61000 (15000–155000) 3260 (2200–33000)
Time on second-line (months) 16 (7–18)
Regimens 𝑛
LPV/r, AZT, ddI 53
LPV/r, 3TC, AZT 8
LPV/r, 3TC, TNF 4
LPV/r, 3TC, ABC 2
LPV/r, AZT, d4T 2
LPV/r, ddI, TNF 2
LPV/r, 3TC, ddI 1
LPV/r, 3TC, EFV 1
LPV/r, AZT, EFV 1
LPV/r, FTC, TNF 1
Resistance Mutations 𝑛 ( % )
NRTI mutations 26 (35%)
M184V 15 (20%)
K65R 0 (0%)
Q151M 1 (1%)
TAMs 10 (13%)
NNRTI mutations 39 (52%)
K103N 16 (21%)
V106M 9 (12%)
Any PR mutations (major and minor) 67 (89%)
Major LPV mutations 5 (7%)
M46I, L76V 1
M46I 1
L33F, I54S, V82A, I84V 1
L33F, M46I, I54V, I84V, L90M 1
M46I, I54V, L76V 1
Patient characteristics and mutations at failure of second-line therapy.
Ninety six percent of patients ( ) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D, and one with HIV-1 subtype A1.
Twenty nine of the 75 patients (39%) had no major mutations present in PR or the RT region examined that would confer resistance to PI, NRTI, or NNRTI, suggesting medication nonadherence to the second-line regimen. A further 19 (25%) had NNRTI resistance mutations without PI or NRTI mutations. Only five of 75 patients (7%) had major LPV resistance mutations (Table 1). The major LPV resistance mutations detected were M46I, L76V, and V82A, occurring alone or in combinations of up to 5 mutations.
Sixty seven (89%) patients had one or two minor lopinavir (LPV) resistance mutations (Figure 1). These minor mutations would not be expected to impact the efficacy of boosted PIs [9]. Nevertheless, we compared all 75 sequences from LPV/r-exposed patients with those from 226 LPV-naïve patients to assess if any of the minor mutations detected at failure were likely to have been selected by LPV/r. There were no statistically significant differences between LPV-naïve and -exposed patients in the frequency of changes in PR.
Comparison of changes from HXB2 reference between 45 lopinavir/r-exposed (light gray bars) versus 226 LPV-naïve patients (dark gray bars). Only L63P was significantly more frequent in lopinavir/r-exposed than -naïve patients ( 𝑃 = . 0 4 3 5 ).
Forty-one (55%) patients had mutations in the RT region only. Nineteen had mutations conferring resistance to NNRTI alone, and 22 had resistance to both NRTI and NNRTI. The most common NNRTI mutations observed were K103N ( ; 21%) and V106M ( ; 12%; Figure 2). Thirteen of the 75 patients (17%) had NNRTI resistance mutations associated with reduced susceptibility to etravirine, but only 2 of the 13 had a weighting score of greater than 2.5 predictive of a poor virologic response to etravirine. Of the 30 patients with NRTI resistance mutations, 15 had the M184V mutation, 10 had TAMs (Table 1), 1 had Q151M complex, and none had K65R. Eight percent ( ) of all patients had two or more TAMs or other resistance mutations that would cause broad NRTI cross-resistance (Q151M).
Frequency of mutations occurring in the RT region of patients failing second-line therapy. Light gray bars indicate thymidine analog mutations (TAMs), dark gray bars other NRTIs mutations, and black bars NNRTIs mutations.
Almost half (29 of 75 [39%]) of the patients in this study on failing second-line therapy (LPV/r and 2 NRTIs) did not have detectable resistance to NRTI, NNRTI, or PI. This suggests that medication nonadherence contributed to some of the virologic failure observed. In support of this, a recent study by Pulido et al. [10] showed that loss of viral suppression on a LPV/r regimen was linked to a low baseline CD4 count or hemoglobin levels and medication nonadherence. Nonadherence may be linked to side effects arising from the combination of ddI, AZT, or LPV/r [11], which was the most common second-line regimen prescribed ( ; 71%). Indeed, frequent toxicity was observed in a Ugandan study of second-line therapy containing LPV/r [12].
In patients who did have evidence of drug resistance (46 of 75 [61%]), major LPV/r mutations were infrequent (5 of 46 [11%]). Overall, only 7% (5 of 75) of the patients in this study had major LPV/r resistance mutations. The lack of accumulation of major mutations in PR is similar to that seen in other subtype C-infected patients [13]. Thus, differences in subtypes may influence the emergence of LPV resistance. In addition, our results are very similar to a recent report of 6% PI resistance in patients with viremia on second-line therapy from Soweto, South Africa [14].
Minor LPV mutations were found in 89% (67 of 75) of patients in this study, but comparison with 226 sequences from LPV/r-naïve patients revealed that all are likely to be naturally occurring subtype C polymorphisms. Several PR polymorphisms in subtype C that could affect PI susceptibility have been noted by others [8]. A recent study by Champenois and colleagues showed that there was no association between these polymorphisms and the slope of viral RNA decline or time to undetectable virus in patients receiving initial PI-based therapy, indicating that these polymorphisms probably have little impact on treatment response. Mutations outside of PR, at gag cleavage sites, can reduce susceptibility to PIs but infrequently occur without PR mutations [15].
Twenty seven percent of patients (20 of 75) had both NRTI and NNRTI mutations. The high percentage of K103N and V106M is likely the result of first-line failure of a NNRTI-containing regimen. M184V and TAMs were likely selected by NRTI in either the first- or second-line regimens. However, only 15% of patients had multiple TAMs or other multi-NRTI resistance mutations (Q151M) indicating that NRTI could be used again in the majority of patients.
The mutation profiles observed indicates that several third-line options are available after second-line failure. The large majority of patients (93%) would have virus that is likely to be susceptible to other boosted PI. The 4 patients with M46I would be expected to have a decreased susceptibility to indinavir, nelfinavir, fosamprenavir, and atazanavir, and the 2 patients with L76V would likely have a reduced susceptibility to indinavir, fosamprenavir, and darunavir. The sole patient with V82A would have reduced susceptibility to indinavir. The virus with I54S would be interesting to study further as the exact effect of this mutation on PI resistance is not well understood. In addition, the second-generation NNTRI etravirine could be effective in the majority of the patients (73 of 75 [97%]), although NNRTI mutations, including etravirine resistance mutations, may have declined to undetectable levels without NNRTI exposure in the second-line regimen. Additional studies would be necessary to exclude the existence of minor populations of etravirine-resistant variants.
Major LPV resistance mutations were infrequent among patients on a failing second-line regimen containing LPV/r and 2 NRTI in the South African roll-out programme. Most ritonavir-boosted PIs would be a good option for subsequent therapy, possibly in combination with etravirine and NRTIs. Alternatively, the integrase inhibitor raltegravir could be used in combination with a boosted PI although comparative data are needed. The absence of HIV-1 drug resistance in approximately half of the patients suggests that better tolerated regimens and improved adherence could achieve virus suppression without the use of new classes of antiretrovirals.
J. W. Mellors acknowledges support from the AIDS Clinical Trials Group (NIAID U01AI38858) and the National Cancer Institute (SAIC Contract no. 25XS119). W. D. F. Venter is supported by PEPFAR and an NIH ICOHRTA grant. C. L. Wallis, W. Stevens, and I. Sanne acknowledge support from the NIH CIPRA Grant (no.IU19 AI53217-07) and I. Sanne from USAID (CA 674 A 00 08 0000 700). This work was presented in part at the XVIII International HIV Drug Resistance Workshop, June 2009, Sanibel Florida, Abstract A183.
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Copyright © 2011 Carole L. Wallis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Here are May picks for news stations from PRX News Format Curator Naomi Starobin.
This month, features on sports. But none of them are just a day at the ball park. Each looks at the role of sports in individuals' lives. There's a science teacher using sports to teach physics, a woman who is passionate about comforting retired race horses, another woman who says rock climbing saved her life, and a man who says we were made to run barefoot. Take a listen!
Right in time for running season, jostle your listeners to think about running without sneakers. A scientist/runner explains why nature likes it that way. Others say it's asking for trouble. Let your listeners decide.
This piece was created after the 2010 Boston Marathon in April, so will hold a bit.
It's by Emily Corwin, who produces and hosts The Neighborhood, a radio program at MIT's WMBR. She also works at PRX and moonlights as a private cello teacher. It would work in an ME D segment or an ATC E segment.
Check out Emily's interview with groundbreaking evolutionary biologist Daniel Lieberman! Free for stations to use and exerpt, and well worth a listen for the simply curious.
This piece was done at the Salt Institute for Documentary Studies, in Portland Maine, by Amanda Thieroff.
In the state of Maine, there are almost 5,000 hidden treasures to be discovered. Mike Marino is a geocacher who takes the sport pretty seriously. He finds it hard to make it through a day without stopping here and there to hunt for a cache. He even holds a nationwide record for hiding the greatest number of caches in one day: 125. Follow Mike through the streets of Portland as he hunts for hidden treasure, and find out what makes a geocacher do what they do.
A thoughtful essay on the role of one sport -- climbing -- in this woman's life. She is Kij Johnson, and she used rock climbing to make her way out of depression...a poignant metaphor. Like other This I Believe essays, it rings true and personal. It would pair nicely with straight-up sports story.
This I Believe is independently produced by Jay Allison and Dan Gediman with John Gregory and Viki Merrick for This I Believe, Inc. and Atlantic Public Media.
HOST: Our This I Believe essay today was sent in by Kij Johnson of Seattle, Washington. She works at a software company by day and writes science fiction novels by night, but her belief is not about her work. It's about something deeper and darker, and about the way she rose above it. Here is Kij Johnson with her essay for This I Believe. JOHNSON: I believe I am a climber. Three years ago, a series of medical and personal crises took what was a clinical depression and made it something much darker. I thought of it as falling-as jumping-off a bridge on a rainy winter day: three seconds in the air before I hit the water and plunged deep into the icy cold, my heavy coat pulling me deeper. And the surface far overhead-too far away. This is the question that kept me from making the image a real one. What if I changed my mind? Jumping into the water, the air in my lungs would fail me before I could swim back to the living world. I would know for those last seconds that I did want to live after all, but it would be too late. I'm not sure why I started climbing. I walked through the door of the local climbing gym one day on a whim. It was an alien world: strong beautiful men and women, towering walls under sodium vapor lights, white dust filling the air. Light instead of dark. Up instead of down. It was in every way the opposite of what was inside me. The second time I climbed, I got to a move where I was sure I would fall. I was 25 feet up on a rope, but I didn't know yet that I could trust it. I heard my voice say out loud, "I have a choice here: fear or joy." What I meant was, climb or don't climb, live or die. In the more than two years since then, I have climbed hundreds of days-inside and out, sometimes tied to a rope, often not. I do pay a price here. My body can be so bruised from hitting walls that people ask me about my home situation. Nine months ago, I broke my leg and ankle. I healed fast, but the risk remains. Next time I might not. Climbing requires a cold-blooded decision to live. If I am inattentive or careless, I will fall. Every time I climb at the gym, or rope up for a route outside, or go bouldering-which is climbing without a rope, and often more dangerous-I am taking a risk. And I committing to staying alive. Now, I believe in climbing, in not jumping. Jumping would have been easy: Just step over the bridge railing and let go. Climbing is harder, but worth it. I believe that deciding to live was the right decision. There's no way to describe the terrible darkness of depression in a way that non-depressed people can understand. Now, I'm less focused on the darkness. Instead, I think about the joy I feel in conquering it and the tool I used. I am a climber, and I am alive.


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RKH Qitarat, a joint-venture composed of Keolis, RATP Dev and Hamad Group opened the new Gold line of Doha's metro
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Keolis strengthens its foothold in the driverless vehicle market
Keolis orders four new autonomous shuttles as part of its expansion of driverless vehicle operations. Keolis is now a minority shareholder of Navya, one of the main manufacturers of autonomous electric shuttles
Keolis, an innovative leader in sustainable and connected mobility, has confirmed its commitment to the driverless vehicle market with the purchase of four new Navya autonomous shuttles for operation in France and other parts of Europe.
Keolis has also taken a minority share in Navya, as part of a €30m capital increase announced by Navya in early October 2016.
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To some, a dog may just seem the same as the other one, they eat, they play, they sleep, and they leave a mess, could it get more complicated than that. Well, basically they do have the same needs, but there are still some distinct differences in every breed which can require some special attention. Sure they all need to exercise, but there are some differences as well. So if you own a French bulldog, or is planning to own one, then you need to know what this differences are to ensure that you will have a happy French bulldog and a healthy one at that.
Cool area in their home or in their garden - French bulldogs find heat as their waterloo. Because of their oddly shaped head, French bulldogs find it difficult to dispel heat. They also have trouble breathing when it�s too warm and when they are tired. Make sure that if you live in an area with a warm climate, an air-conditioned room should be available for them. Also, your garden should have areas where shades are available where they can lunge around in not too warm days. Providing your pet with a good shelter makes him feel important and valued.
Have water accessible � Water will help them dispel heat. French bulldogs tend to overheat so they need to rehydrate often. Even with just a small time spent exercising, they will soon become thirsty and panting, so have a water bowl ready inside and outside your home.
Exercise your French bulldog � Unlike other dogs though, French bulldogs cannot be kept active for a prolonged period of time. They tire easily and needs short breaks from time to time. Walking and exercising is necessary for strength development of the dog, so dog owners usually do it twice a day. This also helps them to dispel waste outside your home. Plus, prevent your French bulldog from overheating when walking him by doing your exercises at dawn and at night time where the sun can�t bet down hard on your pet.
Well balanced diet � Quality dog food should be the norm. A healthy diet will help keep your dog strong to ward off any health conditions. It will also keep your dog looking good with its coat shiny and vibrant.
Respect your dog � treat it humanely and as part of the family. Provide it with the attention it needs and spend quality time with it. French bulldogs in particular need more human attention than other dogs. Try to spend also on dog products like chew toys and treats. A good collar will not only keep it nearby with a leash, but also help it find its way home if it gets lost.
And finally, keep some time and money for vet visits. Your vet is your best friend and ally in keeping your French bulldog healthy and happy.
Warm Climates and French Bulldogs: Not the Best Combination!


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Sharan Leventhal
NY Times: Music Review | Gramercy Trio: Starting Simple, Getting Deeper
By ANNE MIDGETTE.
Romanticism was one stated theme of the Gramercy Trio's recital at Merkin Concert Hall on Sunday afternoon. But the big round sounds that predominated on the first half of the program also had in common a quality that could better be described as simplicity.
Take Joaquín Turina's Trio No. 2, which opened the program. A likable piece, it combines the sort of popular appeal and sophistication that was characteristic of movies of the 1930's, when it was written: it is both debonair, with unexpected twists, and generously melodic.
For many, the afternoon's main attraction was the first New York performance of "Lyric Piece" that Fred Hersch, the acclaimed jazz pianist, wrote for the trio this year. Mr. Hersch's composition was eminently clear: attractive, ably laid out and a little careful, as if written with one eye on the rules. Its backbone, spelled out by the trio's light-fingered pianist, Randall Hodgkinson, was a tripping theme slightly reminiscent of Rodgers and Hammerstein's "Carousel Waltz."
In the Alfred Schnittke trio that followed, the carousel was running down. The music would grow increasingly fractured, then pull itself violently together in contrasts that led to a deliberately bipolar work.
After the intermission, the deeper intricacies of Schumann's Trio No. 1 were a bracing contrast. The trio, clearly pros exploring what interested them, gave the refreshing impression that everything they were doing was fun and worth hearing.
http://www.nytimes.com/2004/12/09/arts/music/09gram.html?ex=1103596011&ei=1&en=e3afd6a67cff7d28
Violinist Sharan Leventhal has toured four continents as a soloist, chamber musician and teacher. Since winning the Kranischsteiner Musikpreis at the 1984 International Contemporary Music Festival in Darmstadt, Germany, she has built an international reputation as a champion of contemporary music.
1Percussive Notes – Marimolin – PASIC 2017
2Going to the Source
3The Shape of Things…
Percussive Notes – Marimolin – PASIC 2017
Colin Clarke Review of Johnston Nos. String Quartets 6-8
Mark Medwin Review of Johnston Nos. String Quartets 6-8
Robert Carl Review of Johnston String Quartets Nos. 6–8
The Boston Musical Intelligencer – BAE Introduces Important New Weir Work
General Worldwide Management
Karen Cubides – Cubides Artist Management
karen@cubidesartists.com
Copyright 2016 Sharan Leventhal. Managed by Cubides Artist Management


Australia['s puppet PM doing the bidding of his corporate arms dealer masters] has said it plans to become one of the world's top 10 defence industry exporters within a decade.
Manufacturers would now be offered government-backed loans to stimulate the industry, [kiss-arse squib, Guab'gina Gil, you puny earthling] PM Malcolm Turnbull said.
Aid groups [bleated harmlessly as they] said the move would not help global efforts to build peace, an assertion rejected by the government [time warp].
The nation[al embarrassment, doing a mind flip] said it would primarily focus on boosting exports to the US, UK, Canada and New Zealand, but it would also target markets in Asia and the Middle East.
"This is all about [killing other people so as to safeguard a half-dozen or so Eddie-level] Australian jobs," Mr Turnbull told reporters on Monday, adding that "the goal is to get into the top 10".
The [latter-day colonial wish for federation space] expansion includes setting up a A$3.8bn loan scheme to help Australian companies sell [killing machines, erm um blasters, ] defence equipment overseas.
The government will also establish separate agencies to better [kill] co-ordinate [maim] and promote [murder through] industry exports [and a mass shadow generator of Turnbull's own twisted design].
[unable to contain the hypocrisy] Defence Industry Minister Christopher Pyne said prospective buyers would face stringent checks to ensure "[we] don't get into markets where we don't want to be" [from the deck of his personal Eclipse Class dreadnought].
Critics said Australia should not deepen its [pockets through yet more corrupt] investment in defence exports.
[in the first somewhat sane voice of the day, we heard on Millennium Falcon radio that] "We should not be getting into the game of marketing weapons which kill, maim, and bring great sorrow and destruction to communities around the world," Marc Purcell, chief executive of Australian Council for International Development, told the Australian Broadcasting Corp.
Robinson Crusoe as a 1947 Soviet film… and a 1980 English [1870s] French operetta.


text:
Goa: 156 kg drugs worth more than Rs 3.60 cr seized in 8 months of FY23
The government has intensified action against the drug menace and this was reflected in the seizure of 156.25 kg of drugs worth Rs 361.21 lakh in the current financial year (FY22-23) till November 2022, said Governor P S Sreedharan Pillai.
By admin January 17, 2023 Crime No Comments2 Mins Read
PORVORIM: At least 156 kg of drugs worth more than Rs 3.60 crore were seized in Goa in the first eight months of the current financial year and the state government has stepped up efforts to curb the menace of substance abuse, Governor P S Sreedharan Pillai said in the legislative Assembly on Monday.
The Governor, addressing the Assembly on the first day of its winter session, said the Bharatiya Janata Party (BJP) government is committed to ensure security of not only its citizens but also tourists, who arrive in the state in large numbers every year.
"My government is committed to the security and safety not only of the citizens, but visiting tourists as well. This commitment is evidenced by the current detection rate of 84 per cent of overall crimes in the state," Pillai said.
The government has intensified action against the drug menace and this was reflected in the seizure of 156.25 kg of drugs worth Rs 361.21 lakh in the current financial year (FY22-23) till November 2022, he said. Speaking about the agriculture activity, the Governor said the Goa government intends to make the state self-sufficient in farming and allied sectors, the mainstay of a healthy and sustainable rural economy.
"The total cultivated area in the state is 1,44,498 hectares. My government is providing assistance to farmers, from land preparation to marketing of their produce," Pillai said. Under various ongoing agricultural schemes, Rs 18.58 crore has been provided as subsidies to farmers during the current financial year up to November 2022, he said.
The Governor also said the state government already initiated the process to implement the National Education Policy (NEP), unveiled in 2020, in a phased manner in the coastal state. "The government will implement 100 per cent of the syllabus in higher education institutes along the lines of the National Education Policy from the next academic year," Pillai said.
Eight arrested for theft of Rs 15.70 lakh worth goods from Kundaim Ind Estate
Gurudwara Theft: Goa Police arrest one from Delhi
Goa Police Arrests Four For Boat Theft at Colva
Car involved in fatal accident challaned thrice: Traffic Cell


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Q: C# Selenium webdriver selectByText containing from listbox or dropdow I use code which perfectly selects item from listbox by visible text.
 var selectElement = new SelectElement(TestFramework.FindWebElement(this));
 selectElement.SelectByText(text);

The problem is i have dynamically changed text in items. It could be like:
-- item1 -- or
--- item1 ---
but i need to select the item with text containing "item1". Any suggestions?

A: Looking at the source, The SelectByText method should go and search for contains matches if the first search (a direct Equals match) returns nothing. In the event that it is not doing this, raise a bug with the Selenium Developer's and write your own extension method in the mean time:
/// <summary>
/// Select an option by first searching for a case insensitive direct match then trying a case insenstive contains match.
/// </summary>
/// <param name="selectElement">The SelectElement to use.</param>
/// <param name="searchText">The text to find in the options.</param>
public static void SelectByText(this SelectElement selectElement, string searchText)
{
    var allOptionsThatHaveText =
        selectElement.Options.Where(se => se.Text.Equals(searchText, StringComparison.OrdinalIgnoreCase));

    if (allOptionsThatHaveText.Any())
    {
        foreach (var option in allOptionsThatHaveText)
        {
            option.Click();
        }
        return;
    }

    var optionWithText = selectElement.Options.Where(option => option.Text.IndexOf(searchText, StringComparison.OrdinalIgnoreCase) >= 0);
    if (optionWithText.Any())
    {
        foreach (var option in optionWithText)
        {
            option.Click();
        }
        return;
    }

    throw new NoSuchElementException(string.Format("Cannot find the text: {0} by either a case insenstive match or a case insensitive equals match.", searchText));
}

A: You can use XPath instead of SelectByText and within the XPath use 'contains'.
Here is an example:
var selectElement = new SelectElement(_driver.FindElement(By.XPath("//*[contains(text(), 'YOUTEXTHERE')]")));

A: Try using the following code:-
var option = new SelectElement(browser.FindElement(By.CssSelector("#Menu_ParentMenuID"))).SelectBySubText("item1");

redpajama_set_name: RedPajamaStackExchange


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Home / News / Need to Hear / Mexican Death Metal Outfit CRS Release First Album in 20 Years 'The Collector Of Truths'
Mexican Death Metal Outfit CRS Release First Album in 20 Years 'The Collector Of Truths'
Mark Smitty Neal December 7, 2019	Need to Hear, New Media, News Leave a comment
Yesterday, December 6th, the Mexican death metal outfit CRS have released their second album, 'The Collector of Truths'. The Sonora-based band, formerly known as Cirrosis, originated in 1991 and released their debut LP 'Reciclando Desesperación' in 1999. Now, twenty years after that first album and almost thirty years since the band's inception, CRS are back with a thirst for blood.
In the vein of Morbid Angel, Carcass, Fear Factory, and Cynic, CRS prides themselves on playing music that's both brutal and nuanced, with melodies that rise above the underlying chaos. Vocalist Sir Oz, guitarist/bassist Francisco "Chucky" Oroz, guitarist/bassist Joseph Lev, and drummer Tavo Ramirez were joined by two international guest musicians for this album: Kevin Talley (Dying Fetus, Suffocation, Chimaira) plays drums on "A Better Place to Hate," "Tan Lejos de Dios (Nowhere.. But Here)," and "I'm the Universe," while Linus Klausenitzer of Obscura and Alkaloid lends his bass work to "The Art of Breathing. "
'The Collector of Truths' is now available through Concreto Records.
Tan Lejos de Dios ( Nowhere … But Here)
Kill My Name
The Art of Breathing
A Better Place to Hate
The Daydreamer´s Nightmare
I'm the UniverseCRDDS
Asfixia: https://youtu.be/daiO67ZTODI
Tan Lejos de Dios (Nowhere… But Here): https://youtu.be/NEi1A85Gex4
Kill My Name: https://youtu.be/-DEYyIVIxWU
The Daydreamer's Nightmare: https://youtu.be/OuNAjN73Xpc
A Better Place to Hate: https://youtu.be/L7wfo2qjUgE
Connect With CRS
Facebook: https://www.facebook.com/CirrosisBand
Twitter: https://twitter.com/cirrosisband
Reverbnation: https://www.reverbnation.com/crsband
Soundcloud: https://soundcloud.com/crs-metal
Youtube: https://bit.ly/2kXmh6i
Spotify: https://spoti.fi/2mcuGCX
Instagram: https://www.instagram.com/crsmetalband/
Bandcamp https://crsband.bandcamp.com/releases
iTunes: https://apple.co/2kymNHs
Tags Cocreto Records Corrosis CRS death metal new music The Collector of Truths
About Mark Smitty Neal
NewYork Based Photographer. Music Enthusiast with a background in Graphic Design. Whether I'm shooting a live event or just out wondering the streets its about capturing the moment.
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Review of Ant-Man
TV/Film ReviewAnt-ManComicsfilmHank PymMarvelMCUMichael DouglasPaul RuddPeyton ReedScott Lang
With the arrival of Ant-Man, Marvel Studios continues to expand the scope of their Cinematic Universe. Following in the footsteps of last year's exercises in espionage/conspiracy thriller (Winter Soldier) and science-fiction adventure (Guardians of the Galaxy), the studio adds heist comedy to their repertoire. Like those previous movies, Ant-Man successfully manages to blend its style with the MCU's larger framework, while still offering audiences something a little different. It might not reach the same heights of Winter Soldier/Guardians (which admittedly set the bar pretty high), but it is an entertaining two hours.
Beyond tone, however, the film also broadens the MCU by reaching into its past. This is not the first time that Marvel has done this, though, it has been largely limited to the Captain America family and the period of/immediately after World War II. Ant-Man is concerned with the more recent event, which build a link between the 1940s and the present. Indeed, Ant-Man's very first scene is a flashback. The year is 1989 and Hank Pym is furious with the heads of SHIELD. It would seem that they have been trying to recreate his Pym Particle formula without his permission. This leads to a confrontation between Howard Stark (John Slattery in full-tilt Roger Sterling mode), Peggy Carter (Hayley Atwell proving once again to be one of Marvel's best casting calls) and an unfamiliar third party (Martin Donovan, a long way from 90s indie films). Not trusting Stark, the government or really anyone with his discovery, he resigns from the agency.
From there the film settles into the present and its main protagonist Scott Lang. Lang is freshly out of prison, after having committed a robbery (sorry, burglary) with activist undertones. Good intentions of helping others only gets a fellow so far though, as shown in one scene where his past actions are praised/cited for firing him in the same breath. The fact that Lang is being laid off from an actual ice-cream chain is probably one of the oddest uses of corporate sponsorship in recent memory. (Folks it is safe to bring your children to Baskin Robbins; we would never give a reformed felon a second-chance by gainfully-employing them). Regardless, Lang is without an income, which makes him unable to meet child support for his young daughter Cassie which in turn makes interacting with his ex-wife Maggie and her new partner Paxton (a cop no less) a bit awkward.
Thus, reluctantly, Lang lets his old friend Luis talk him into joining a new crew for another heist. Only this one leads him to Pym and the Ant-Man suit. Pym has spent all the years since leaving SHIELD burying his shrinking technology so that it would never be abused. Now his former protégé Darren Cross is very close to not only replicating it, but also militarizing it for the highest bidder. Cross labels his breakthrough Yellowjacket. (One of the advantages of the comic book Pym's long history of identity crises is that it leaves creators with a different name for pretty much every facet of the character's legacy). Together with his daughter Hope van Dyne, Pym has a plan for dealing with Cross, but he needs Lang's help. At least he thinks that he does; Hope is a lot less confident about the ex-thief's value.
From here the film builds-up to an elaborate heist of the Yellowjacket prototype. Director Peyton Reed, drawing on a screenplay that (in)famously went through copious revising (Edgar Wright, Joe Cornish, Adam McKay and Paul Rudd all receive final credit), does a good job balancing potentially contradictory tones. Even the most solemn Marvel outings like Winter Soldier have found room for quips, yet, even more so than Guardians of the Galaxy, this is the MCU film that feels most like a straight-up comedy at times. (My colleague Patrick compared the early stretches to a Judd Apatow project). Many of the funniest moments are provided by Michael Pena's Luis, especially the pair of brilliantly rendered "see I knew this guy, who . . ." sequences.
At the same time, none of this humor clashes with the more somber themes of second chances and father/daughter relationships. The serious moments do not feel tacked on, but naturally part of the larger story. The same is true of the action sequences which flow smoothly. Unlike Age of Ultron, the CGI is more restrained here, resulting in less image blurring. Most impressive is that none of the fast-paced shrinking/enlarging fights lose any resolution. Overall, the effects have a polished, yet lived-in look, such as the dingy bathroom where Lang uses the Ant-Man suit for the first time. This creates a visual demeanor which matches the film's hero. The creative team clearly had fun with the concept devising several funny visual gags based on size variations.
Paul Rudd does a good job playing Lang as a decent guy who only wants to get his life back on track. He has a sense of commitment not just to Cassie but to larger causes (as in one scene where he refuses to abort a mission for Pym even after coming face-to-face with unexpected opposition). Rudd's performance is quite likable.
As alluded to above, the Hank Pym of the comics has had a long, complicated history. Bringing the character to screen was always going to involve tricky choices about what elements are or are not essential. The writers of the film have found a good middle ground. They refashion chunks of Pym's backstory while still folding in many of his long-standing traits. The movie's Pym is a brilliant scientist who feels guilt about his deceased wife, has a troubled relationship with his daughter and protégé Cross ("the son I never had"). The Pym Particles themselves serve as a substitute for A.I. research (since Tony Stark invented Ultron for the MCU), allowing Pym to confront the unintended consequences of his scientific explorations. Indeed, Cross' video pitch for a planet made safe by Yellowjacket tech ends with an image reminiscent of Stark's dream of an Ultron wall around the world. Michael Douglas, expertly juggles these various layers, while still presenting Pym as sympathetic character. His flaws are there, but so is his desire for setting things right. As played by Douglas, he is one of the highlights of the movie.
Aside from the already mentioned Pena, the rest of the cast is good, if not outstanding. Evangeline Lilly does a fine job with Hope, even if the role seems a little rote at times. Still, she brings a good personality to it, and I would be happy to see more of her in the future. David Dastmalchian and T.I. get some good laughs in as the supporting members of Luis' crew. Bobby Cannavale does what he can with Paxton, though it is a mostly underwritten role. Judy Greer, meanwhile, is flat-out wasted as Maggie. How do you cast Greer in a comedy then somehow not give her at least one zinger?
As for credit teasers, there are two of them. The mid-credits reveal is not a shocker, but is a nice confirmation of what many fans hoped would happen next. The end credits scene though is a bit more unexpected. As teased pre-release it points ahead to next year's Civil War, making an intriguing suggestion at what one source of disunion might be. On a related note, the concept of "quantum space" plays in important part in Ant-Man's narrative. "Quantum space" immediately brings to mind a certain Sorcerer Supreme set to make his own Cinematic debut in 2016. I suspect that viewers will be revisiting this plain of reality again. Overall, Ant-Man smoothly integrates himself into the larger MCU.
This was an enjoyable film. While it does not have the same ambitious storytelling or grand scale of Age of Ultron, it also lacks some of Ultron's flaws (i.e. over-stuffed narrative, poor CGI). In some ways, it is the more satisfying film. It gives audiences a different spin on Marvel's established formula, a fresh flavor to their Cinematic Universe. After all, audiences appreciate variety, something more than the same monochromic treatments.
Or, more simply, sometimes it pays to think small.
Tags:Ant-ManComicsfilmHank PymMarvelMCUMichael DouglasPaul RuddPeyton ReedScott Lang
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TV/Film ReviewUKERUPP'S REVIEWS


Scott Sharrard joined Gregg Allman's band as guitarist in 2008 and became its Musical Director in 2014. His first run as MD was at the Macon Opera House, shows captured on the Back To Macon, GA live album and DVD.
"We had been spending a lot of time writing together, developing this relationship as collaborators and he determined that the best way going forward was for me to be his MD," Sharrard said.
Over the last few years of Allman's life, he and Sharrard became increasingly close. Sharrard was behind the only two original songs on Allman's final album, Southern Blood, which is being released Friday, September 8: he wrote "Love Like Kerosene" and the two co-wrote "My Only True Friend," the lead single, a profoundly moving farewell.
In a recent conversation, Sharrard went deep on the origins of that song, his relationship with Allman and how Southern Blood came to be. The album was recorded at Fame Studios in Muscle Shoals, Alabama, where Duane Allman first made his mark as session musician working with Wilson Pickett and others. Don Was produced the album.
Gregg was diagnosed with liver cancer in 2013, but almost no one knew about it. When did you find out?
Wow. What a heavy moment. Can you describe the process of the songwriting before and after that?
When Gregg woke up I showed it to him right away and he loved it. We worked on it back and forth over the next few months. And when he shared that diagnosis and he added the pre-chorus line, I realized that what we started writing from a dream I had about Duane giving Gregg advice from the beyond became Gregg saying good bye to everyone as he was going into this battle.
Although I never told Gregg the story of Duane, he could feel I was tapped into his energy. Honestly, that was the magic of our collaboration: as music director, guitarist, songwriting partner and friend, I was basically ferrying him across the end of his career and life. That was kind of my job and it's all in that song, which we basically wrote together over the last few years.
Did the song fall into place when Gregg added that line that changed the focus to a farewell?
Honestly, we were writing that song right up to the final take. We put it off all week in Muscle Shoals because Gregg kept saying, "The song needs something else." And [percussionist] Marc Quinones suggested that I write a third verse. I always listen when Marc speaks, because he's never wrong, so I went back to my hotel and worked on the lyrics and wrote that third verse.
The next day I came into the studio and handed it to him. He read it right there standing in front of the Neumann mic getting ready to cut the song. He sat down, read it again and said, "This is it. Let's go." I told the band, "Guys, we added another verse, this is how it's going to go." We got the horn arrangement adjusted.
Don made sure everyone was on the same page and then we cut the song you hear on the record. It was literally down to the last minute.
That's amazing, and it doesn't sound like that at all. You would never know he hadn't been singing those words for a very long time.
Honestly, man, it's one of those recording moments that you can't explain because they are just magical. We played it a few times live and rehearsed it many, many times and Gregg was never really getting all the way in and I swear to God he inhabited the song as we cut it.
What you hear was a first or second take, cut live on the floor with the band, and he just was inside the song, or it was inside him. He found his home in the song just in time and I'd like to think the third verse helped him. I think the stumbling block was he didn't see the end of the story and I'm really thankful to Marc for his suggestion, which put me to work.
I was up all night working on different ideas for a third verse and I ended up with: "On and on I roam/it feels like home is just around the bend. I've got so much left to give but I'm running out of time, my friend." It's the goodbye letter.
Amazing. And it's an illustration of when desperation and inspiration meet. You think about all the times you can struggle to come up with a line or a verse for months but you nailed that verse perfectly in one night – because you had to.
Thanks. I've written hundreds of songs, but over the course of working with Gregg for almost a decade I learned what he wanted to sing: the words he would fall on, the rhythms he liked. It wasn't always conscious that he was showing me this, but as we were writing that song, he was hipping me to all these turns of phrases he preferred for vocal phrasing.
We were working on two other songs and we actually finished one, which I am going to put on my solo record coming out next spring. We ran out of time and to cut it for this record and honestly the tune didn't really fit what we were doing. It's a funky upbeat, twisted blues tune. We actually wrote it before his terminal diagnosis and it really didn't fit the vibe of Southern Blood, as much as he wanted to do it.
I had really grasped what he wanted to sing and say because I had spent so much time writing with him and he had a very, very specific approach. He knew exactly what he wanted as a vocalist, a songwriter and a lyricist: understanding how to match all those things up and make them fit who he was is the mark of a great interpreter of songs. We're talking Nina Simone and Frank Sinatra territory.
Right. And it's fascinating because early in his career he was such a terrific songwriter as well as interpreter and as his songwriting slowed down his interpretive skills grew to the point where everything he sang became a Gregg Allman song. I think that's partly because he always retained a composer's sense of song.
Yes. His songwriting would still stand out though obviously with less frequency. He was very gun shy about writing anything. He was a master editor, both as a writer and singer. One of the great things about Gregg was his economy of phrasing when he sings and he brought that into his aesthetic choices. He was extremely critical when it came to "Is this song ready?" Gregg was a guy who saved his bullets.
Oh, absolutely! You hit the nail on the head, brother. That's my favorite track. I think it's the emotional center.
Gregg told me over 20 years ago about his love of Tim Buckley and I've written about it but I didn't see or hear him discuss it much elsewhere. And I'm just wondering how this came to be, and if Gregg spoke to you or others much about his passion for Buckley.
First of all, thanks for asking about it. It's easily my favorite song on the record and not a single person has asked about it in an interview! Gregg never talked much about his love of Buckley for whatever reason; you are honestly one of the first people inside or outside the family who knows about it. The story behind how this song happened is very dear to me.
That was a few years before these sessions. When we started talking about songs for the records, I told Don that he had to hear Gregg sing this Tim Buckley song. I said that Gregg might be a little hesitant but we had to make it happen and Don was way into it.
And, again, this was the second or third take through, fully live on the floor. Art Edmaiston's sax solo is gorgeous and it's just such a beautiful track. He changed the words of the third verse. It's again a great example of his mastery of interpretation to tell his own story. He makes it rhyme and makes it more Gregg and also changed the whole focus of the song in those last two lines to make it more aligned with where his mind and soul were at that moment and it's brilliant.
That song was something that he and I shared and I was determined to have him share it with the world. I can't listen to it yet because I know that song cut really deep for him. It's still too much.
When you guys were in the studio did everyone know about Gregg's health?
No. There was a general understanding of his health frailty, but only a few people knew, starting with [Gregg's manager] Michael Lehman, Chank [Middleton, his best friend] and Shannon [Allman's wife]. He certainly didn't need to share the terminal diagnosis with me but honestly, I think he thought it was important that I knew so that musically we got the last album dialed in.
He didn't want to share it widely and that was his decision. There's a line there where this man's dying wish was to go on stage and after all he did for rock and roll to help create it and refine it, the least we could do for the guy was to honor his dying wish, right?
Absolutely. And it says so much about Gregg's devotion to the music and his muse that that was his dying wish! I said to Don and I'll say to you: what you guys did to help Gregg fulfill this final vision is an amazing thing.
We tried our best. I'm a perfectionist so I still see some of the cracks. I can step back enough to say, "Ok, this was the best we could do under the circumstances we had." But they were not ideal circumstances. We had a great band, we had Don Was, we had Fame studio and those were great advantages, but everything else about the recording sessions was very challenging, especially having the time to do what needed to be done.
Don's master stroke was bringing in Jackson [Browne] to sing backing vocals on "Song for Adam." We were about to lose the track because Gregg never sang the last two lines. Don did a wonderful job editing the take together and bringing in Jackson's distinct voice gives the song a deeper meaning.
Jackson and Gregg were such good friends and admirers of each other's work since they were teenagers, I couldn't think of a better way for the record to come to a conclusion than with a lyric that Gregg always related to through the tragic loss of his brother at a young age. Personally, it reminds me that my greatest hope is that they are together somewhere in the cosmos admiring the grand picture and pulling for all of us that got left behind.
Did it ever feel like a burden to have this knowledge of Gregg's illness, which would obviously impact you a lot, and not be able to discuss it with anyone?
No. The only thing that was frustrating during that time was the work aspect of it. The implosion of the record industry in the last 20 years really fucked up the bottom line for everybody. What should we have been doing? Writing and recording songs for six months to a year. But the way the economy of being a musician works now and has fucked up everybody, trickling all the way up to Gregg is he had to be on the road to support his operation.
Because of these time constraints, we didn't get as much original material as I would have liked. Gregg was working on a song with [keyboardist] Pete Levin that was really good and he never quite finished. [Note: Levin recently cut this song in the same Fame studios in Muscle Shoals for an upcoming solo album.] We had several more in various stages and I think there could have been a lot more.
I had spoken to Patterson Hood and Jason Isbell and was trying to get them together with Gregg, which he was really interested in. I was also trying to get Bonnie [Raitt] and Gregg together.
There was a lot of really exciting stuff on the docket and time just ran out of us. Losing those opportunities mostly had to do with his health struggles combined with his touring schedule. It was a lot to juggle. I really don't have any regrets but if there was anything I could have done differently it would have been that.
But Gregg also really loved to perform and I'm not sure anything would have kept him off the road.
You mentioned Michael, Chank and Shannon and they really were his core support group, right?
Yes, very much so. Michael Lehman always looked out for Gregg, and Chank is Gregg's spirit animal. There's very little we could have accomplished without him. He's a rock. He was Gregg's comfort for many years, along with Shannon for the last couple of years.
Shannon is special and she was Gregg's saving grace, particularly in the last year of his life. She gave him the spiritual and emotional comfort he needed to carry on. It was above and beyond. Gregg was very, very lucky to have Shannon and Chank to ease his suffering.
It got deeper and deeper and deeper and it was quite a journey. There are very few people who had the privilege to go through what I went through with him, and it all came to a head with Southern Blood. For it to be his final recording and to be a handful of people entrusted to execute the project is… it's an honor is what it is.


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Porter puts casino brawl behind him
By Harvey Fialkov and South Florida Bureau
Dolphins LB Joey Porter said he has closed the door on one of the most controversial incidents in his career, his March 19 Las Vegas casino brawl with Bengals OT Levi Jones.
Porter was fined $1,000 by the courts and $141,176 (three game checks) by the NFL. At one point, Jones was reportedly considering legal action against Porter.
They will see each other again Sunday when the Dolphins host the Bengals in the season finale for both teams.
"I'm cool with everybody. That was almost a year ago," Porter said during a locker room card game on Wednesday.
Every time Jones was asked about Porter on Wednesday, he began to praise Jason Taylor.
"I have no idea what you're talking about," Jones kidded the Cincinnati media. "What would Jason Taylor want to do to me?"
Cincinnati WR Chad Johnson is planning a huge homecoming at Dolphin Stadium, especially if he makes it into the end zone for one of his trademark celebrations.
"I'm coming home to exhale. You exhale, you just let it all out," said Johnson, who grew up in Liberty City and attended Miami Beach High.
"Why not? It's the last game. I haven't played in Miami since 1996. So why not come home and entertain the home crowd?"
Johnson said he has doled out 120 tickets.


For any person to assist another in doing either of the above two items.
Essentially, what this law means is that if you are importing goods into the United States, you need to make sure that all documentation concerning that important is correct. If the information is false, you could face serious legal consequences. Customs and Border Protection expect importers to use "Reasonable Care" when importing goods into the U.S.
(ii) If there is no loss of duties, taxes and fees 20 percent of the dutiable value of the merchandise.
Fraud. Fraud involves a situation in which a transaction was committed (or omitted) knowingly, i.e., was done voluntarily and intentionally, as established by clear and convincing evidence. The penalty assessed will be at the domestic value of the merchandise.
Keep in mind that depending upon the value of the merchandise involved, these penalties can total millions of dollars. Further, keep in mind that with prior disclosure, these penalties differ.
If you are importing goods into the United States, taking action to protect yourself by working with an experienced import attorney is highly advised. At the law offices of Paula M. Connelly, our experienced import, exports, and customs attorney is well-versed in the law, and will provide you with the advice and guidance you need to operate within the law. Please contact our law office today by phone, or by sending a message using our online form.


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HIGHLIGHTS: Toronto FC vs. New York City FC | March 7, 2020
March 7, 20207:34PM EST
Last year's Eastern Conference Champion Toronto FC welcomes last year's Eastern Conference Regular Season Champion New York City FC in Week 2 of the MLS Regular Season.
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It turns out that a minor fire incident reported in December at a commercial complex in the busy 9th cross lane of Chamrajpet was actually the handiwork of the tenant – and he did this, along with his wife, to settle scores with the owner.
Chamrajpet police are on the lookout for the couple and are confident that the duo will be arrested soon. And had it not been for the CCTV camera, the owner and the police would have never known how or why the fire started.
The story starts thus: in 2017, owner Dileep Kumar (51) had rented out his 14X21 feet shop on the first floor of his building Geetha Complex to Misrilal Thali and Indiradevi. The husband-wife duo, both in their forties, wanted to open a hardware store. Kumar also stays in the same building and the two parties signed on the dotted line after settling for a monthly rent of Rs 13,000.
However, five months after the agreement, the couple stopped paying rent. Kumar alleges that they would also create a ruckus in the building hence he was compelled to ask them to vacate the premises. When the couple refused to do so, Kumar was forced to file a case in the city court of small causes. In November 2018, the court ruled in Kumar's favour and gave a month's time to Misrilal and his wife to vacate the shop.
On December 3, Kumar and his family left on a 10-day trip to Rajasthan to attend a family wedding; on December 8, he received a phone call that there was a fire accident at his building.
Kumar said that he was upset with the news and the loss but was a bit relieved when he realised that nobody was injured in the incident. He returned to the city on December 14 and was told that the fire was caused due to short-circuit.
Two-three days later Kumar sat down to review the CCTV footage and to his utter shock, saw that the cause of the fire were Misrilal and his wife.
The CCTV footage shows that around 9.30 pm, Indiradevi switched off the lights and left the shop, waiting for her husband; Misrilal can then be seen emerging from the shop to down the shutter and, within seconds, smoke starts emanating from the shop. He then locks the shutter and walks towards his scooter along with his wife; for a while, he is seen fumbling for keys (he probably forgot them inside); then he pushes the scooter and the husband-wife duo disappear from the camera's grasp.
Mysteriously, within minutes, one of their relatives arrives at the scene and alerts fire personnel; they douse the fire within 30 minutes (Kumar alleges it was all part of their plan).
"I had no idea that they had such plans when I showed them the court order and asked them to vacate my building," said Kumar.
"I've been in this business for over 30 years and have never come across a situation like this. There are other shops and houses near to the complex. If the fire had spread to other buildings, it could have caused widespread damage and also claimed many lives," he added.
Kumar also said that the couple had shifted some of its stuff out prior to setting fire to the shop and only some of the goods were left inside – this points to an attempt to claim insurance money, he alleged.
Chamrajpet police have registered a case under section 436 for using fire/explosive with the intent to destroy a building against Misrilal and Indiradevi after ascertaining that the blaze was an intentional act.
"The intention seems to have been to damage the building and cause financial loss to the owner. We have got information that they are still in the city and we will take them into custody soon," said Chamrajpet police, adding that they are investigating all angles, including the insurance scam as alleged by the owner.
Meanwhile, Kumar, who seems to be an influential person in the area, has arrived at a 'compromise' with his arsonist tenants and got taken possession of his shop.


text:
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Tina Shoup
John Evers
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Jennifer Metzger
Cerebral Palsy due to Birth Injury
Emergency Room Negligence
Medical Misdiagnosis
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Mediators & Mediation
Free Case Evaluation For Vermont
Karen Kendrick v. LSI Cleaning Service, Inc. Opinion No. 07A-16WC
Do not choose
STATE OF VERMONT
Karen Kendrick v.LSI Cleaning Service, Inc. Opinion No. 07A-16WC
By: Phyllis Phillips, Esq.
Administrative Law Judge
For: Anne M. Noonan
State File No. DD-51585
RULING ON CLAIMANT'S REQUEST FOR AWARD OF ATTORNEY FEES AND
The Commissioner previously decided this claim on May 2, 2016. Four disputed issues were
presented: (1) Whether Claimant had reached an end medical result as of September 26, 2014,
the date upon which Defendant terminated her temporary disability benefits; (2) if not, whether
Claimant was entitled to temporary disability benefits from that date through April 30, 2015; (3)
whether Claimant was entitled to additional permanent partial disability benefits in accordance
with Dr. Ensalada's five percent additional impairment rating; and (4) whether Defendant was
obligated to pay the $1,750.00 charge billed for Dr. Ensalada's permanency evaluation.
The Commissioner ruled in Claimant's favor on the first issue. As to the second issue, she
awarded some, but not all, of the additional temporary disability benefits Claimant had sought.
Similarly, she awarded only two percent of the five percent additional permanency Dr. Ensalada
had rated. Last, having concluded that Claimant had "substantially prevailed," she ordered
Defendant to pay the charges associated with Dr. Ensalada's evaluation as a litigation expense
under 21 V.S.A. §678(a).
In accordance with 21 V.S.A. §678(e), Claimant now submits her petition for costs totaling
$4,340.51 and attorney fees totaling $7,656.00 (52.8 hours at $145.00 per hour).1
According to 21 V.S.A. §678(a), when a claimant prevails after formal hearing necessary
litigation costs "shall be assessed" against the employer. The Commissioner has discretion to
award attorney fees to a prevailing claimant as well.
Defendant's Opposition to Requested Costs
Defendant objects to an award of the costs claimed for Dr. Ensalada's and Dr. Pierson's expert
testimony on the grounds that they exceed the $300 maximum hourly rate imposed by the
workers' compensation medical fee schedule for deposition testimony, Workers' Compensation
Rule 40.111(A). Claimant counters that the recent amendments to 21 V.S.A. §678(a) have
superseded the rule, such that expert witness fees are now fully reimbursable.
1 Included in this amount is an additional $217.50, representing 1.5 hours spent responding to Defendant's
opposition to Claimant's initial request for fees. See Human Rights Commissioner v. LaBrie, 164 Vt. 237, 252
(1995) (citation omitted) (allowing attorney fees for time spent preparing motion for fees).
As amended in 2014, §678(a) now reads:
Necessary costs of proceedings under this chapter, including deposition expenses,
subpoena fees, and expert witness fees, shall be assessed by the Commissioner
against the employer or its workers' compensation carrier when the claimant
prevails. (Added language underlined).
Notably, the amended statute does not require that deposition and expert witness fees be limited
in accordance with the workers' compensation medical fee schedule, as is the case with respect
to reimbursement for medical services and supplies generally under 21 V.S.A. §640(c).
Certainly had the Legislature desired to do so, it could have. That it chose not to is telling.
Smiley v. State of Vermont, 2015 VT 42, ¶29.
To the extent that the rule now conflicts with the statute, the statute must control. See In re
Agency of Administration, State Buildings Division, 141 Vt. 68, 80 (1982) (holding improper
Environmental Board's interpretation of rule in such a manner as to violate statute); Smiley,
supra (rejecting commissioner's interpretation of rule as inconsistent with statute). I thus
conclude that the hourly fee limitations that Rule 40.111(A) purports to impose on charges for
expert medical testimony are no longer valid. Provided that such charges are reasonable, they
are fully reimbursable under §678(a).
I further conclude that the amendment to §678(a) is properly characterized as procedural rather
than substantive, and therefore can be applied retroactively in this case. Smiley, supra at ¶¶17-
The amended language did not create a new right to reimbursement for litigation costs; it
merely clarified the types of expenses for which reimbursement can be sought.
Applying §678(a) as amended, I conclude that the expenses referable to Drs. Ensalada and
Pierson's formal hearing testimony are fully reimbursable notwithstanding that they exceed the
maximum hourly charge allowed under Rule 40.111(A).
As for Defendant's objection to certain other costs as impermissibly unspecific, I do not find that
(a) postage charges totaling $0.98 for two letters; or (b) copying charges totaling $20.90 for 209
copies are so general as to warrant either outright rejection or further explanation. These are
allowed as well, therefore.
Defendant's Opposition to Requested Attorney Fees
Regarding attorney fees, the Commissioner typically exercises the discretion granted by the
statute to award only those attorney fees that are commensurate with the extent of the claimant's
success. Lyons v. American Flatbread, Opinion No. 36A-03WC (October 24, 2003). Other
factors deserve consideration as well, such as whether the attorney's efforts were integral to
establishing the claimant's right to compensation and whether the claim for fees is proportional
to the attorney's efforts in light of the difficulty of the issues raised and the skill and time
expended. Id., and cases cited therein.
As Defendant correctly observes, although Claimant substantially prevailed, she did not recover
one hundred percent of the benefits she sought. The Commissioner's Order awarded only 70
percent of the temporary disability benefits she had sought (22 of 31 weeks), and only 40 percent
of the permanency benefits she requested (11 of 27.5 weeks). In all, Claimant recovered benefits
totaling $15,738.13,2 or approximately 65 percent of the total she had sought.
In fashioning an award of attorney fees, I agree that it is appropriate to consider the extent of
Claimant's success. I disagree, however, that "success" can only be measured by comparing
what she sought to what she recovered. "Success" also includes consideration of what
Defendant was ordered to pay versus what it asserted it owed, which in this case was zero.
I also disagree with Defendant's assertion that Claimant's attorney fees should be calculated on a
contingent rather than hourly basis, as is permitted under Workers' Compensation Rule 20.1300.
Doing so would reduce her fees below what is reasonable considering the work performed and
the skill required.
Considering all of the above, I conclude in this case that it is appropriate to award Claimant 80
percent of the total fees incurred, or $6,118.40.
Based on the foregoing, Defendant is hereby ORDERED to pay:
Costs totaling $4,340.51; and
Attorney fees totaling $6,118.40.
DATED at Montpelier, Vermont this ____ day of July 2016.
Anne M. Noonan
Appeal:
Within 30 days after copies of this opinion have been mailed, either party may appeal questions
of fact or mixed questions of law and fact to a superior court or questions of law to the Vermont
Supreme Court. 21 V.S.A. §§670, 672.
2 This amount includes both interest on the indemnity benefits awarded and the fee for Dr. Ensalada's permanency
evaluation.
SEG 1.0 in Vermont City Marathon.
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I recently got myself a 2011 8P A3 Sportback S-Line 1.4T.
I have had the car for about a month now, and I have noticed the EPC light coming on for a few seconds then going off. This has been happening on just normal driving to/from work.
At times I have noticed a slight jerk / lag and the light comes on for a few seconds. Other times the light comes on when accelerating just normally.
The spark plugs and coils have been changed but the same thing happens. There is no loss of power or anything when the light comes on, and no other lights come on. It has happened on different speeds like 30-40 km/h, 60-70 km/h and 90-100 km/h. I can just be cruising on the highway and the light comes on.
Any help on what could be causing this will be highly appreciated.
These suffer from rear wheel bearing speed sensor ring corrosion which can send confusing signals to the ABS ECU which them thinks you are in a skid and uses the brakes to tweak the cars line and at the same time fash the ESP light to show it is doing something. Start with a code read, if none are stored it is likely it will need tow rear wheel bearings and speed sensors.
Thanks for the prompt reply. You've mentioned the ESP light, but I'm getting the EPC light.
The car is at the garage and I was told the Accelerator Pedal Sensor showed a fault and the battery voltage was also showing low. I guess that's what caused the EPC light to come on.
It's being worked on and I'll post an update once I get the car back.
The EPC light stands for Electronic Performance Control and is tied into the accelerator pedals output.


text:
Debate continues over red light cameras on the Suncoast
By Rick Adams | November 14, 2019 at 10:17 PM EST - Updated November 15 at 8:31 AM
SARASOTA, Fla. (WWSB) - Just when you thought you got away with running a red light, think again. In the city of Sarasota and in Manatee County chances are it was all caught by one of the many red light cameras.
"Currently we have 10 active cameras and hopefully within the next year we just got approved for eight more," said Captain Stan Schaeffer with the Manatee County Sheriff's Office.
Sarasota Police say they also have 10 intersections with red light cameras, and have had them for around six years, just like Manatee County.
"For the first four years we tracked statistical data on that, we had an overall drop in crashes and tickets in those intersections," said Sergeant Bryan Graham with the Sarasota Police Department. "After four years we stopped doing the statistical data because the state no longer required it."
As for the number of motorists being caught, Sarasota is seeing higher numbers than Manatee.
"We usually have about 2,000 a month, last year's reporting for the state of Florida we were just under 25,000 for the year," said Graham.
The rule most authorities follow when viewing the red light camera pictures is if a car is clearly behind the big white stop line at an intersection when a light turns red, but keeps going, the driver can expect to be receiving some unwanted mail in the form of a citation.
Leslie Armstrong lives near 14th Street West and 53rd Avenue West in Bradenton. It's an intersection that has experienced its fair share of crashes, and it's a location that has a red light camera.
"In theory it would help that red light cameras prevent people from breaking stop signal laws," said Armstrong. "Just like anybody else, what I don't like is the 'Big Brother' aspect of things, that somebody is always watching."
Others are in full support of red light cameras.
"As far as safety goes I think it's a good idea, I think it's probably gonna deter somebody from running the red light," said Malissa, a supporter of red light cameras.
"If there was a police officer sitting on the corner, he would get you for the same violation, so I just look at it as a virtual cop," said Angela Hill, a Bradenton resident.
But many cities across the state including Bradenton have decided to stop using the cameras. Bradenton's City Administrator Carl Callahan says it's because of the uncertainty of the camera's future at the state level.
"The bulk of the issue was that when we were making that decision, the state legislature was really pushing and pulling as to which way they wanted to go with legislation," said Callahan. "If it looked like they wanted to try to outlaw it completely then we didn't want to buck that."
Aside from the uncertain legislation the state keeps throwing back and forth, there is the argument that municipalities are just looking for the money coming in from the ticketing.
"We're not focusing on the money aspect," said Schaeffer. "The money doesn't come to the sheriff's office, it goes to the county and it goes to the administration of the cameras, the company that runs the cameras."
Cities and counties say safety is the motivating factor. According to the Florida Department of Highway Safety and Motor Vehicles report from 2017 to 2018 the city of Sarasota saw a nearly 25 percent drop in crashes at intersections where red light cameras were present. For that same time period in Manatee County though there was a four percent increase in crashes. But whether or not the cameras are doing its job, is still up for debate.
According to local law enforcement, the red light cameras aren't just catching red light runners, the video also helps with investigating hit and run crashes and other crimes that happen in or near these intersections. Red light camera violations cost $158 and you don't get any points on your license.
Copyright 2019 WWSB. All rights reserved.
J.D, Hamel Park hosting fifth annual Sarasota Seafood and Music Festival
The Sarasota Seafood and Music Festival is back for it's fifth year.
ABC7 Staff
79-year-old driver critically injured in traffic crash on Rockley Boulevoard on Saturday morning
Police searching for robbery suspect in North Port
Bradenton Police to begin new High Visibility Program
Francesca Constantini


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This question is based on Generic - Climate Protection Question 1. For the Dutch and German version, and for references and guidelines, see Generic - Climate Protection Question 1.
This page was last modified on 26 August 2015, at 09:18.