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BizSPORTS continued from page 17 Every year, Tucson one ups itself. And Accenture and the PGA take notice.
Favorite Memories from the Links
PGA TOUR in Tucson Since 1945
By Steve Rivera "It was the year Tiger Woods went to a playoff (in 2008) and The Gallery Golf Club at Dove Mountain isn't suited for galleries. He made a putt to tie the match after being down three with three to play. He made a putt at 18 to extend the match. "It was late in the day and just beautiful. I was helping with the marshals and crowd control. When we had to move to the No. 1 hole after being at 18 there was a huge crowd that Tiger brings with him. It was a crowd of chaos and bliss at the same time. "Controlling the crowd was amazing. It gave you the feel of a big-time golf event and the things you see at the British Open and these huge events. It was a memorable moment." – Heath Bolin, 2014 Tournament Chairman, Tucson Conquistadores
"It had to be 2009 and all the First Tee kids were out there watching practice. There must have been 35 kids and we were walking down the 18th fairway. Tiger Woods was practicing on the other side. All the kids yelled, "Tiger." He waved (he couldn't stop because he was headed to talk to the media). "We then walked to the 17th green and Sergio Garcia was there with Adam Scott and Luke Donald. They were practicing. Scott and Donald signed a bunch of autographs and Sergio Garcia signed an autograph for every kid. Oh, my gosh – the kids will remember that." – Judy McDermott, Executive Director, Tucson Conquistadores
"Just watching Tiger Woods practice is exciting. This is one of the most famous people in the world. I walked one year following Geoff Ogilvy and Steve Stricker, and any time you can watch people who are the best at what they do, it's is amazing. Hey, if these shots aren't five feet from the hole on a par three, they are mad. These guys are phenomenal. It's a pleasure to watch them." – Ed Honea, Mayor, Town of Marana
"One of the more compelling matches I've had a chance to see was between Hunter Mahan and Rory McIlroy (in 2012). Rory was No. 1 in the world and watching Hunter match him shot for shot, and seeing him overtake him was remarkable. Golf fans enjoyed watching that duel." – Brent DeRaad, President & CEO, Visit Tucson
"I always take a moment during Wednesday's opening round of the Accenture Match Play Championship to stop and take in the atmosphere at the first tee. It is one of the most underrated days on golf's calendar, in my opinion. We have 64 of the world's best, broken up into 32 matches going head to head. "I love the win-or-go-home feeling in the air that day, both at the beginning as players make their way to the opening tee or later in the day as matches start to conclude. It's something that only happens at our event." – Gerald Goodman, Executive Director, Accenture Match Play Championship
Biz 18 BizTucson
"Tucson and Southern Arizona have long supported PGA TOUR events dating back to 1945 with the start of the Tucson Open," said Peter Kent, VP of championship management business affairs at the PGA TOUR. "Through tournament changes and even a few snowstorms, the fans, volunteers, Conquistadores and corporate sponsors in Tucson have shown great support of the World Golf Championships – Accenture Match Play Championship," he added. So, of course Tucson wants Accenture to stay. Always has and always will. "The one thing you can hang your hat on is that Tucson gets the best of the best when it comes to golf, having the top 64 players come here," said Heath Bolin, 2014 tournament chairman for the Conquistadores. "Phoenix has the Cardinals and the NFL. They've had a World Series. They have the Suns and have had an All-Star game. "We have our No. 1 Cats. But when it comes to pro sports, the Accenture Match Play is something special. Phoenix doesn't get the top 64. This is truly special and important to the community. It's something we have to hold on to. We've had great support in the past and what people need to do is buy tickets." Blessed With Eight Years
It's been a great, wild ride from the moment they made the announcement they'd be coming to where the greens are smooth and the fairways are generous. "That's the whole thing," said Judy McDermott, executive director of the Tucson Conquistadores. "We thought we'd get them for four years and that would be it. We've been blessed to have them eight. "In our wildest dreams did we ever think we'd get Match Play because we were playing opposite them," McDermott said. "First to land it and have it be extended and then extended again, we never thought that would happen. We've always done really well with the event. Whoever thought we'd have all these CEOs flying into Tucson to see the event? It's been fantastic." Of course, the Conquistadores, Tucson and everyone involved from that end would love for it to continue. "We've been good for Match Play and Accenture – and Match Play has been good to Tucson," said Neal Weitman, president of the Tucson Conquistadores. "We've had great success the past eight years. "To have that quality of field here is great – and it would be equally as great to have the marriage extended. "We don't know what the future holds, but we certainly hope that it can continue," he added. continued on page 20 >>> www.BizTucson.com


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Halfords CIO Anna Barsby leads 2015 CIO 100
Mid-sized businesses that are tackling digital disruption lead this year's CIO 100 of transformation technology leaders
Anna Barsby, CIO of retailer Halfords, has been named the leader of the 2015 CIO 100. Chris Hewertson of hotel business glh and David Jack of Hyperion Insurance follow close behind.
Barsby of outdoor, cycling and motoring retailer Halfords was recognised by the panel of CIO 100 judges for the strength of her leadership to re-energise a business that looked set face the same demise as other major retailers such as Blockbuster and Woolworths. The panel were impressed with how all three leaders in the CIO 100 were tackling head-on the major disruptions within their sectors, in particular from technology. Halfords is competing strongly against a plethora of new online rivals, new out of town retailers and a struggling retail sector as consumer confidence in the national and world economy remains low. Hotel and insurance are also markets that are witnessing major change from new market entrants and customer behaviour.
Barsby takes the number one spot for her focus on people leadership to deliver business transformation and a clear and concise communication of what the strategy is. The midlands-based CIO describes leading 100 people as "definitely a non-technology responsibility". Barsby's relationship with other key members of the executive team was also cited by the panel for recognition.
CIO 100 judge Mike Altendorf said: "The senior business people really see Barsby as an equal, and in a business that is facing digital and retail challenges she's been a part of affecting that change and she is a core part of the executive team."
Fellow judge Jayne Nickalls described Barsby as "a fantastic role model for the CIO post", while CIO columnist Ian Cox said: "It is clear she is part of a business team and she's driving and conceiving elements of the business strategy."
Hewertson is applauded by the CIO 100 panel for putting the customer - and how the customer wants to use technology during their stay - at the heart of his hotel technology vision. Again, Hewertson impressed the panel with his strategy and communications. David Jack at financial services organisation Hyperion Insurance has been at the forefront of major change at venture capital-owned Hyperion and is shaking up the vendor community as a result. The panel were impressed by the focus on data and the transparency of that data across the organisation.
The top 10 of the 2015 CIO 100 also features Christina Scott of the Financial Times whose increased role to include product ownership and a close involvement in the business strategy impressed the panel. Richard Corbridge, now with the Irish health service, but previously CIO of The Clinical Research Network in the UK, also impressed the panel for his information strategy, modern vendor selection and his move to being a CIO and CEO in Ireland. Also in the public sector James Findlay, CIO of both proposed rail network HS2 and the Department for Transport impressed the panel for his bold new way of managing vendors, projects, the creation of parliamentary Acts and again communication. While so many other Whitehall departments focus on their legacy systems and processes, the panel agreed Findlay was a breath of fresh air.
2014 CIO 100 leaders Stephen Kneebone and Phil Jordan of Nissan Europe and Telefonica respectively remain in the top 15 for their continued transformational leadership at two major global organisations.
While the 2014 CIO 100 highlighted how big organisations can change under transformational leaders like Jordan and Kneebone, the 2015 CIO 100 recognises that mid-sized organisations such as Halfords, glh, Hyperion and the FT are empowering their CIOs to deal with business disruption and lead transformation.
The CIO 100 is a critique of the CIO role to celebrate and highlight the importance of the CIO and their role in business transformation. The list is created by a panel of experts, most of whom have been CIOs at major organisations such as May Gurney, Sony, BBC, NHS, UK government and ICI.

redpajama_set_name: RedPajamaCommonCrawl


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Learn more about the dedicated staff at Theater Latté Da. Peter Rothstein, Co-Founder and Artistic Director and Denise Prosek, Co-Founder and Resident Music Director
Peter Rothstein
Co-Founder I Artistic Director
Email: peter@latteda.org
Peter Rothstein has directed 72 mainstage productions for Theater Latté Da, including 11 world premieres. Other recent collaborations include the Guthrie Theater, the Children's Theater Company, Minnesota Opera, the Illusion Theater, Ten Thousand Things, Minnesota Orchestra, Utah Shakespeare Festival, Seattle's 5th Avenue Theater, and Asolo Rep. He is the creator of All is Calm: The Christmas Truce of 1914 and Steerage Song–a docu-musical created in collaboration with Dan Chouinard. Peter was named the 2015 Artist of the Year by the Star Tribune, Theater Artist of the Year by Lavender, and Best Director by City Pages. He has received nine Ivey Awards and has been awarded grants and fellowships from the National Endowment for the Arts, Theatre Communications Group, the Minnesota State Arts Board and the McKnight Foundation. He holds a B. A. in Music and Theater from St. John's University and a Master of Fine Arts in Directing from the University of Wisconsin-Madison. Peter-Rothstein.com
Denise Prosek
Email: denise@latteda.org
Denise Prosek has worked extensively as a music director, pianist, and arranger in the Twin Cities for the past twenty years, including forty mainstage productions for Theater Latté Da. She has also music directed for Children's Theatre Company, the Guthrie, Park Square, Mu Performing Arts, Ordway Center for the Performing Arts, Hennepin Theatre Trust, and the Ivey Awards, among others. Denise holds a Bachelor of Music from St. Olaf College. She was named a Playwrights' Center McKnight Theater Artist Fellow in 2013-2014, Outstanding Musical Director in 2006 and 2008 from Star Tribune, Best Music Director in 2010 from Lavender, and Theater Artist of the Year in 2012 from Lavender.
Michelle Woster
Email: michelle@latteda.org
Michelle Woster was hired as the first managing director of Ten Thousand Things in 2003, where she worked for ten years with the company's small staff and board to grow this locally-recognized treasure into a leader on the national theater scene. For the past four years she held senior development positions at the Center for Victims of Torture and The Family Partnership. Michelle holds a B.A. in English from The University of St. Thomas and a M.P.A. from The University of North Carolina–Chapel Hill. She lives in Northeast Minneapolis with her husband Peter Quale and their three children.
Elissa Adams
Associate Artistic Director
Email: elissa@latteda.org
Elissa Adams has spent her career developing new work. In her 19 seasons as Director of New Play development at Children's Theatre Company, she commissioned and developed more than 45 new plays and musicals that premiered at CTC and went on to productions across the country. She was Literary Manager/Dramaturg at La Jolla Playhouse and Director of Playwright Services at The Playwrights' Center, where she oversaw the Center's Jerome and McKnight Fellowships and served as Artistic Director of PlayLabs. She is a frequent dramaturg at the Sundance Theatre Lab, an Adjunct Professor at MCAD, a recipient of the McKnight Theatre Artist Fellowship and a former Board Member at Open Eye Figure Theatre and TYA/USA. She holds an MFA in Dramaturgy from UC San Diego.
Allen Weeks
Production Director
Email: allen@latteda.org
Allen has been working in the Twin Cites as a production manager, stage manager, and designer since graduating from Minnesota State University, Mankato with a degree in Technical Production. Before working with Theater Latté Da he was the Production Manager at Penumbra Theatre and Actors Theater of Minnesota, and the Company Manager at Climb Theater. Allen has also done work with Sample Night Live, Theatre Mu, Walt Disney World, Sesame Street Live/VEE Corporation, ShopNBC, Bloomington Civic Theatre, Virginia Luoma Dance, Minnesota Fringe Festival, Keane Sense of Rhythm, and many others.
Email: andrew@latteda.org
Andrew is a marketing and branding professional in non-profit arts marketing in the Twin Cities. He holds a master's degree from the University of Innsbruck School of Management in Strategic Management and Multi-Cultural Branding. A theater and arts advocate and supporter, Andrew served as Director of Marketing for Berkeley Symphony prior to joining the staff at Theater Latté Da and served as Marketing & Communications Manager at Lyric Arts Company prior to that. With a love for choral music, Andrew continues to support choral music ensembles in Minnesota both as a singer and board member for choral music ensembles in the Twin Cities.
Libi Baehr
Email: libi@latteda.org
Libi has been a dedicated lover of the arts since learning to play the saxophone at age 9. Originally from Virginia, Libi graduated with a BS in Business and Enterprise Management from Wake Forest University and held Development positions at Sixth & I in Washington, DC and Children's Theatre Company in Minneapolis before joining Theater Latté Da in October 2018. She is passionate about exploring how art can connect people and using fundraising as a tool for telling stories and building community. When not at Theater Latté Da, you can find Libi at one of the Twin Cities' many live music venues, or re-watching Star Wars at home with her cat.
Chris Cartwright
Email: chris@latteda.org
Chris is a 2019 graduate of Concordia College in Moorhead, MN with a B.A. in both Communication Studies and Theatre Art. Prior to serving as TLD's Marketing Associate, he worked for 4 years as the PR & Marketing Manager for Concordia Theatre, managing everything from media relations and community engagement to marketing and box office. He was also the Marketing & Development Intern at Churches United for the Homeless and the Radio Production Intern at Prairie Public Broadcasting. Additionally, Chris is a performer, director, librettist, and published playwright. His plays have been produced in schools, fringe festivals, and community theatres across the country and abroad, earning numerous accolades. In his free time, you can almost always find Chris at a coffee shop, listening to public radio, attending concerts, and supporting the incredible local music scene. Learn more about his plays and other experiences at christophercartwright.weebly.com.
Tiffany K. Orr
Email: tiffany@latteda.org
Tiffany is celebrating her ninth season as the Production Stage Manager at Theater Latté Da. While on staff, she has stage managed over 20 productions including Six Degrees of Separation, Ragtime, C., Gypsy, Sweeney Todd, Oliver, Cabaret, Spring Awakening & Evita. While in the Twin Cities, she has had the opportunity to work with many amazing companies including the Guthrie Theater, The Children's Theatre Company, and the Pillsbury House Theatre. This summer Tiffany will return to Wichita, KS for her ninth summer as a part of the stage management team at MTWichita. Tiffany is a proud member of Actors' Equity Association.
Renata Nijiya
Email: boxoffice@latteda.org
Renata Nijiya moved to Minnesota after graduating from Longwood University with a BFA degree in Theatre Performance and began working as a costume designer with companies such as 20% Theatre, Walking Shadow, Mixed Blood and Workhaus Collective at The Guthrie Theater. She joined Ballet of the Dolls as a company dancer in 2010 as well as working as Director of Audience Services for The Ritz Theater until 2014. Renata can be seen on stages throughout the Twin Cities as her alter-ego Queenie von Curves, producer of Naked Girls Reading, or found snuggling at home with her wife, three cats and two French bulldogs.
Bethany Reinfeld
Email: bethany@latteda.org
Tricia Hofeld
Email: tricia@latteda.org
Micayla Thebault-Spieker
Master Electrician & Rentals Manager
Roni McKenna
Accounting Consultant
Millie Annis
Michael Dunne
Concessions Manager
Diane Beck
Concessions Supervisor
Janet Lewis
Grace Peterson
Courtney Rust
Zach Windschitl
Concessions Staff
Michael Hanisch
mindthemind@me.com


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Naturstoffe & Metabolomics
Biofunktionale Synthese
Computerchemie
Daten & Ressourcen
Ludger Wessjohann
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Drača, D.; Mijatović, S.; Krajnović, T.; Kaluđerović, G. N.; Wessjohann, L. A.; Maksimović-Ivanić, D. Synthetic Tubulysin Derivative, Tubugi-1, Against Invasive Melanoma Cells: The Cell Death Triangle Anticancer Res 39, 5403-5415, (2019) DOI: 10.21873/anticanres.13734
Background/Aim: Tubugi-1 is a more stable and accessible synthetic counterpart of natural tubulysins. This study aimed to evaluate its cytotoxic potential against anaplastic human melanoma cells. Materials and Methods: The viability of A-375 cells was determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet assay. The type of cell death and proliferative rate were investigated using flow cytometry and fluorescent microscopy, while the molecular background was evaluated by western blot. Results: Tubugi-1 reduced the viability of A-375 cells, inducing massive micronucleation, followed by augmented expression of inhibitor of nuclear factor-κB and caspase-2, typical of a mitotic catastrophe. Disturbed proliferation and G2M block with prominent caspase activity, weakened the expression of B-cell lymphoma 2 and B-cell lymphoma 2-associated X transient up-regulation, coexisted with intensive autophagy. Specific inhibition of autophagy by chloroquine resulted in conversion from mitotic catastrophe to rapid apoptosis. Conclusion: Multilevel anticancer action of tubugi-1 is extended by co-application of an autophagy inhibitor, giving a new dimension in further preclinical advancement of this potential agent.
Drača, D.; Mijatović, S.; Krajnović, T.; Pristov, J. B.; Đukić, T.; Kaluđerović, G. N.; Wessjohann, L. A.; Maksimović-Ivanić, D. The synthetic tubulysin derivative, tubugi-1, improves the innate immune response by macrophage polarization in addition to its direct cytotoxic effects in a murine melanoma model Exp Cell Res 380, 159-170, (2019) DOI: 10.1016/j.yexcr.2019.04.028
Synthetic tubugis are equally potent but more stable than their natural forms. Their anticancer potential was estimated on a solid melanoma in vitro and in vivo. Tubugi-1 induced the apoptosis in B16 cells accompanied with strong intracellular production of reactive species, subsequently imposing glutathione and thiol group depletion. Paradoxically, membrane lipids were excluded from the cascade of intracellular oxidation, according to malondialdehyde decrease. Although morphologically apoptosis was typical, externalization of phosphatidylserine (PS) as an early apoptotic event was not detected. Even their exposition is pivotal for apoptotic cell eradication, primary macrophages successfully eliminated PS-deficient tubugi-1 induced apoptotic cells. The tumor volume in animals exposed to the drug in therapeutic mode was reduced in comparison to control as well as to paclitaxel-treated animals. Importantly, macrophages isolated from tubugi-1 treated animals possessed conserved phagocytic activity and were functionally and phenotypically recognized as M1. The cytotoxic effect of tubugi-1 is accomplished through its ability to polarize the macrophages toward M1, probably by PS independent apoptotic cell engulfment. The unique potential of tubugi-1 to prime the innate immune response through the induction of a specific pattern of tumor cell apoptosis can be of extraordinary importance from fundamental and applicable aspects.
Seixas, N.; Ravanello, B. B.; Morgan, I.; Kaluđerović, G. N.; Wessjohann, L. A. Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH2 Core and Evaluation of Their Anticancer Activity Pharmaceutics 11, 59, (2019) DOI: 10.3390/pharmaceutics11020059
Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (i-Pr) and cationic (–NH2) or anionic (–COOH) groups. Standard viability assays were used to evaluate the anticancer potential of the water-soluble dendrimers against PC-3 prostate and HT-29 colon cancer cell lines, as well as non-cancerous mouse NIH3T3 fibroblasts. It could be demonstrated that the anticancer activity against PC-3 cells was considerably improved when both chlorambucil and –NH2 (cationic) groups were present on the dendrimer surface (1b). Additionally, this dendrimer showed activity only against the prostate cancer cells (PC-3), while it did not affect colon cancer cells and fibroblasts significantly. The cationic chlorambucil-dendrimer 1b blocks PC-3 cells in the G2/M phase and induces caspase independent apoptosis.
Kufka, R.; Rennert, R.; Kaluđerović, G. N.; Weber, L.; Richter, W.; Wessjohann, L. A. Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells Beilstein J Org Chem 15, 96-105, (2019) DOI: 10.3762/bjoc.15.11
Tubugi-1 is a small cytotoxic peptide with picomolar cytotoxicity. To improve its cancer cell targeting, it was conjugated using a universal, modular disulfide derivative. This allowed conjugation to a neuropeptide-Y (NPY)-inspired peptide [K4(C-βA-),F7,L17,P34]-hNPY, acting as NPY Y1 receptor (hY1R)-targeting peptide, to form a tubugi-1–SS–NPY disulfide-linked conjugate. The cytotoxic impacts of the novel tubugi-1–NPY peptide–toxin conjugate, as well as of free tubugi-1, and tubugi-1 bearing the thiol spacer (liberated from tubugi-1–NPY conjugate), and native tubulysin A as reference were investigated by in vitro cell viability and proliferation screenings. The tumor cell lines HT-29, Colo320 (both colon cancer), PC-3 (prostate cancer), and in conjunction with RT-qPCR analyses of the hY1R expression, the cell lines SK-N-MC (Ewing`s sarcoma), MDA-MB-468, MDA-MB-231 (both breast cancer) and 184B5 (normal breast; chemically transformed) were investigated. As hoped, the toxicity of tubugi-1 was masked, with IC50 values decreased by ca. 1,000-fold compared to the free toxin. Due to intracellular linker cleavage, the cytotoxic potency of the liberated tubugi-1 that, however, still bears the thiol spacer (tubugi-1-SH) was restored and up to 10-fold higher compared to the entire peptide–toxin conjugate. The conjugate shows toxic selectivity to tumor cell lines overexpressing the hY1R receptor subtype like, e.g., the hard to treat triple-negative breast cancer MDA-MB-468 cells.
Publikationen in Druck
Makong, Y. S.; Fotso, G. W.; Mouthe, G. H.; Lenta, B.; Rennert, R.; Sewald, N.; Arnold, N.; Wansi, J. D.; Ngadjui, B. T. Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae) Nat Prod Res (2019) DOI: 10.1080/14786419.2019.1655024
The chemical investigation of the root barks leaves and stem barks of Brucea antidysenterica J. F. Mill. (Simaroubaceae) led to the isolation of a new pregnane glycoside, named Bruceadysentoside A or 3-O-β-L-arabinopyranosyl-pregn-5-en-20-one (1) together with seventeen known compounds. Their structures were established from spectral data, mainly HRESIMS, 1 D and 2 D NMR and by comparison with literature data. Compounds 1, 2, 5, 6, 8, 10, 12 and 13 were tested in vitro for their effects on the viability of two different human cancer cell lines, namely prostate PC-3 adenocarcinoma cells and colorectal HT-29 adenocarcinoma cells. No substantial activities were recorded for 2, 10, 12 and 13 (up to 10 μM concentration). 1, 5 and 8 did not show strong anti-proliferative effects up to 100 μM, however, 6 exhibited a stronger anti-proliferative effect with IC50 values of ∼ 100 μM against PC-3 and ∼ 200 μM against HT-29.
Sakna, S. T.; Mocan, A.; Sultani, H. N.; El-fiky, N. M.; Wessjohann, L. A.; Farag, M. A. Metabolites profiling of Ziziphus leaf taxa via UHPLC/PDA/ESI-MS in relation to their biological activities Food Chem 293, 233-246, (2019) DOI: 10.1016/j.foodchem.2019.04.097
Ziziphus plants are well recognized for their nutritive and medicinal value worldwide, albeit their chemical profile has yet to be fully reported. The secondary metabolites profile of three traditionally used Ziziphus leaf accessions was investigated via ultra-high performance liquid chromatography coupled to photodiode array and electrospray ionization mass detectors (UHPLC/PDA/ESI-MS). A total of 102 metabolites were characterized revealing the first holistic approach onto Ziziphus leaf metabolome and to include the first report of several novel flavonoids and cyclopeptide alkaloids. Fragmentation pattern for cyclopeptide alkaloids was proposed via ESI-MS. Principal component analysis (PCA) revealed close metabolite resemblance among Z. spina-christi and Z. mauritiana leaf specimens found enriched in saponins and distinct from that of Z. jujuba in which quercetin-3-O-(2-pentosyl)-rhamnoside was most abundant. Further, in-vitro antioxidant, anti-inflammatory and antidiabetic assays revealed for Z. spina-christi and Z. mauritiana strong effects compared to Z. jujuba and in correlation with their metabolites repertoire.
Pantelić, N. Đ.; Lerbs, M.; Wolf, K.; Wessjohann, L. A.; Kaluđerović, G. N. In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-(naphthoquinone)cysteine derivatives J Serb Chem Soc 84, 1119-1127, (2019) DOI: 10.2298/JSC190322032P
Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(1,2-dion-4-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dion-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (1H, 13C, 119Sn) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29), and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range of 0.17 to 0.87 μM. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 ± 0.01 μM, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 ± 0.01 μM, which is ~26 times better than cisplatin.
Shaaban, S.; Ashmawy, A. M.; Negm, A.; Wessjohann, L. A. Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma Eur J Med Chem 179, 515-526, (2019) DOI: 10.1016/j.ejmech.2019.06.075
Nineteen organoselenides were synthesized and tested for their intrinsic cytotoxicity in hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their corresponding selective cytotoxicity (SI) was estimated using normal lung fibroblast (WI-38) cells. Most of the organic selenides exhibited good anticancer activity, and this was more pronounced in HepG2 cells. Interestingly, the naphthoquinone- (5), thiazol- (12), and the azo-based (13) organic selenides demonstrated promising SI (up to 76). Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Moreover, most of the synthesized candidates manifested good free radical-scavenging and GPx-like activities comparable to vitamin C and ebselen. The obtained results suggested that some of the presented organoselenium candidates have promising anti-HepG2 and antioxidant activities.
Tabassum, N.; Eschen‐Lippold, L.; Athmer, B.; Baruah, M.; Brode, M.; Maldonado‐Bonilla, L. D.; Hoehenwarter, W.; Hause, G.; Scheel, D.; Lee, J. Phosphorylation‐dependent control of an RNA granule‐localized protein that fine‐tunes defence gene expression at a post‐transcriptional level Plant J (2019) DOI: 10.1111/tpj.14573
Mitogen‐activated protein kinase (MAPK) cascades are key signalling modules of plant defence responses to pathogen‐associated molecular patterns (PAMPs, e.g. bacterial flg22 peptide). The Tandem Zinc Finger Protein 9 (TZF9) is an RNA‐binding protein that is phosphorylated by two PAMP‐responsive MAPKs, MPK3 and MPK6. We mapped the major phosphosites in TZF9 and showed their importance for controlling in vitro RNA‐binding activity, in vivo flg22‐induced rapid disappearance of TZF9‐labelled processing body‐like structures and TZF9 protein turnover. Microarray analysis showed a strong discordance between transcriptome (total mRNA) and translatome (polysome‐associated mRNA) in the tzf9 mutant, with more mRNAs associated to ribosomes in the absence of TZF9. This suggests that TZF9 may sequester and inhibit translation of subsets of mRNAs. Fittingly, TZF9 physically interacts with poly(A)‐binding protein 2 (PAB2), a hallmark constituent of stress granules – a site for stress‐induced translational stalling/arrest. TZF9 even promotes stress granule assembly in the absence of stress. Hence, MAPKs may control defence gene expression post‐transcriptionally through release from translation arrest within TZF9‐PAB2‐containing RNA granules or perturbing PAB2 functions in translation control (e.g. in the mRNA closed‐loop model of translation).
Mijatović, S.; Bramanti, A.; Nicoletti, F.; Fagone, P.; Kaluđerović, G. N.; Maksimović-Ivanić, D. Naturally occurring compounds in differentiation based therapy of cancer Biotechnol Adv 36, 1622-1632, (2018) DOI: 10.1016/j.biotechadv.2018.04.001
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated. We will presently discuss the natural compounds that show these properties, with focus on anthraquinones from Aloe vera, Senna, Rheum sp. and hop derived prenylflavonoids.
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One of our favorite plus size designers Jibri has just revealed her latest collection for fall. The fall collection is filled with rich velvet dresses and skirts. Each piece has Jibri's notable side draping. In addition to velvet, there are fit and flare plaid dresses with pleated skirts. You'll also find window pane blouses, and trousers pants.
As a designer Jibri has always created unique pieces. This fall collection is no different. Her designs are a mix of modern classics with exaggerated details. For the fall season Jibri designed a high waisted velvet maxi skirt with slouch pockets. There's even a lime green t-neck sweater dress that is rich and bright in color. However, you will also find a few wardrobe staples like printed swing skirts, cocoon maxi knit dresses, and a long sleeve flare dress in a beautiful maroon color.
I read this article and found it very interesting, thought it might be something for you. The article is called Designer JIBRI Unveils New 2017 Fall Plus Size Collection and is located at https://stylishcurves.com/designer-jibri-unveils-new-2017-fall-plus-size-collection/.


text:
Q: C++ classes (public, private, and protected) How can classes in C++ be declared public, private, or protected?

A: You can implement "private classes" by simply not publishing their interface to clients.
I know of no way to create "protected classes".

A: It depends if you mean members or inheritance. You can't have a 'private class', as such.
class Foo
{
public:
Foo() {} //public ctr
protected:
void Baz() //protected function
private:
void Bar() {} //private function
}

Or inheritance:
class Foo : public Bar
class Foo : protected Bar
class Foo : private Bar

A: In C++ there is no notion of an entire class having an access specifier the way that there is in Java or C#.  If a piece of code has visibility of a class, it can reference the name of that class and manipulate it.  That said, there are a few restrictions on this.  Just because you can reference a class doesn't mean you can instantiate it, for example, since the constructor might be marked private.  Similarly, if the class is a nested class declared in another class's private or protected section, then the class won't be accessible outside from that class and its friends.

A: By nesting one class inside another:
class A
{
public:
    class B {};
protected:
    class C {};
private:
    class D {};
};

redpajama_set_name: RedPajamaStackExchange


Thank you for your participation in the 2016 Urban Waters Federal Partnership National Training Workshop! In an effort to strengthen the urban waters community and support your work going forward, please take a few minutes to provide feedback on the workshop.
* 3. a. Overall, what was most valuable to you in this Workshop? Check all that apply.
b. Please share details. This helps us continue to support these national workshops!
* 4. What is one action you'll take in the next week to follow up on your experience?
* 5. We currently have 19 designated Urban Waters Federal Partnership Locations and many other places have expressed interest in joining the Federal Partnership. Are you from a location or do you know of a place that might be interested in joining? If so, please share your location, name and contact information so we can follow-up with you. Please also share any thoughts you may have about growing the Urban Waters Federal Partnership beyond the current 19 designated locations.
* 6. To support your work, please describe follow-up webinars or conference calls that you would find most valuable. Please provide details/potential speakers. What would be the key topics of interest to you?
* 7. Why did you choose to attend? What motivated you to choose the sessions you did?


William A. Torchia, Esq. | William A. Torchia, Esq.
William A. Torchia, Esq. (est. 1997) is located off Rittenhouse Square in Center City Philadelphia. In addition to offering regular legal services at our office, we also offer Concierge Legal Service, i.e., the attorney comes to you.
Our Legal Services are based on the belief that our clients' legal needs are of the utmost importance. We also offer more attorney-client contact than you would find in a large firm. Legal fees are notably less then a client would pay for a larger firm. Consequently, a high percentage of our business is referrals from repeat-clients and other law firms.


text:
Aside from FIFA World Cup, Here Are Other Major Trophies In Football
Ken Ibenne / December 9, 2022 / Featured, Hot Football/Soccer News, News, World Cup 2022
FIFA World Cup is arguably the most coveted trophy in the world currently and every player would love to lift one in their career. The victorious squad must feel immense joy and accomplishment when they clutch this prize.
It's not just the winning squad that celebrates when they take home this trophy. Winning the World Cup may bring a nation together, generating a positive wave of happiness and competitiveness across a country.
Since it was founded in 1930, the World Cup has been held every four years. with the exception of 1942 and 1946, when the Second World War halted it.
Major Trophies in Football
There are numerous contests and trophies in football. The most important international football tournaments are listed below.
The largest accomplishment (competition) in international football is the World Cup. This important event is played by thirty-two teams and occurs every four years.
Can't wait for #DeepikaPadukone to unveil this trophy 🏆#FIFAWorldCup pic.twitter.com/E4T4qqTnS0
— Rishabh Jain ऋषभ जैन (@Rishabhchhajerr) December 5, 2022
The FIFA World Cup association football tournament's champions are given the World Cup, a solid gold trophy.
Two trophies have been used since the World Cup's inception in 1930: the Jules Rimet Trophy from 1930 to 1970 and the FIFA World Cup Trophy from 1974 to the present.
At $20 million, it is one of the most costly awards in sporting history.
France won the 2018 World Cup in Russia after defeating Croatia by a score of 4 goals to 2. In 2022, Qatar is hosting the 22nd edition of the tournament.
FIFA Confederations Cup (Abolished 2019)
The confederation tournament champions, the host nation, and the world cup champions all qualify for this group of teams to compete in a FIFA Confederations Cup.
Additionally, it occurs every four years, just like the World Cup. The only nations with two FIFA Confederations Cup victories are Brazil and France.
Germany defeated Chile 1-0 to win the most recent Confederations Cup, which was played in Russia in June 2017.
See also Croatia shocks Brazil, Wins 4-2 on Penalties to Reach Second Consecutive World Cup Semi-finals
Continental (non-international)
UEFA European Football Championship
This competition, sometimes known as the Euro, is the most viewed in Europe (internationally). Every four years, it takes place (two years before the next World Cup happens).
Nine groups make up the qualification for this tournament, with the top two teams from each group, the best third place, and the winners of a play-off between the remaining third place teams moving on to the subsequent major group round, and so on. The most titles, three, were won by Germany and Spain. The most recent championship was won by Italy in 2021, defeating England on penalties 4-3.
The senior men's national teams of the member associations of UEFA, the sport's European governing body, compete in the new biennial UEFA Nations League international association football competition.
In September 2018, immediately following the 2018 FIFA World Cup, the first tournament began.
League A's four group winners will advance to the finals, which will take place in June 2019 in an undetermined European location.
Four nations will also be eligible to compete in the UEFA Euro 2020 finals, one from each League.
The 55 UEFA national teams, including Kosovo, will be split into four divisions (referred to as "Leagues"), with 12 teams in League A, 12 teams in League B, 15 teams in League C, and 16 teams in League D, in accordance with the format that was previously approved (before Kosovo became a member of UEFA).
ON THIS DAY 2 YEARS AGO:
Portugal won the 1st ever edition of the UEFA Nations League and Cristiano Ronaldo won his 2ND INTERNATIONAL TROPHY. 🇵🇹🏆 pic.twitter.com/kfcwhst08k
— The CR7 Timeline. (@TimelineCR7) June 8, 2021
Four groups are created in each league, with three or four teams in each group, and they compete against one another both at home and away.
Although Australia is permitted and has once won the tournament, this is the primary competition for Asian nations.
See also Manchester City's Kyle Walker Fights the Press After he Reportedly Breach Lockdown Guidelines Again
The Asian Football Confederation hosts the AFC Asian Cup, an international association football competition.
After Copa América, it is the second-oldest continental football championship in history. The victorious team is crowned Asia's champion.
CAF Africa Cup of Nations
For the CAF (African) nations, this is the primary rivalry. Every two years, it features 16 teams from Africa and is held in January or February in the same year as the Summer Olympics and the UEFA European Championship Finals.
It is the greatest accomplishment of any international African squad. Senegal took up the trophy in the most recent competition, which took place in Cameroon in February 2022.
CONMEBOL Copa América
This is where the CONMEBOL faces its toughest foreign opposition. It consists of all of the CONMEBOL's teams.
The time it will occur vary regularly because there is no set interval.
Argentina, who has won the title 15 times, defeated Brazil in 2021 with a 1-0 triumph. Argentina and Uruguay are the countries with the most victories (15 time winners). 2011 saw Uruguay's most recent Copa America victory.
The CONCACAF region's primary competition is this one. With 8 titles, Mexico now holds the record for most victories.
The most recent champions, the United States, follows them with six titles, followed by Canada with one. Additionally, there is no set time frame for this.
The Oceania Football Confederation (OFC) members compete in an international association football tournament known as the OFC Nations Cup.
From 1996 to 2004, it was contested every two years; prior to that, Oceania Nations Cup was the name of two further events that were staged at sporadic intervals.
There was no competition in 2006, but the New Zealand national football team won the 2008 edition, which also served as a qualification tournament for the 2009 FIFA Confederations Cup and a play-off for the 2010 FIFA World Cup.
Club competitions
The major club competitions are listed here.
See also Benjamin Mendy of Manchester City denied bail again ahead of his rape and sexual assault trial
The FIFA Club World Cup trophy was part of our mini exhibition dedicated to the 2019 tournament 🤩
It shows a ball being supported by seven pillars, representing the six teams from each confederation and the competition's host country 🏆⚽ pic.twitter.com/ogtP6trpQ1
— FIFA Museum (@FIFAMuseum) February 6, 2021
This trophy, which was previously known as the Intercontinental Cup, is the only one to include the best top clubs from all six confederational titles. Chelsea won the most recent championship in 2022.
UEFA Champions League and Europa league
The Champions League is the largest matchup between winners of European leagues. 32 teams are qualified for a round robin, after which 16 teams from each group advance to the knockout, quarterfinals, semifinals, and finals.
The Asian Football Confederation hosts the AFC Champions League, also referred to as the Asian Champions League, which is a yearly continental club football competition.
The competition, which debuted in 2002, is a continuation of the Asian Club Championship, which had begun in 1967.
The UEFA Champions League is more prestigious than the CAF Champions League. It is also played similarly to UEFA's, except after numerous qualifying leg rounds, eight clubs are in the group stage.
Wydad AC won the title most recently in 2022, and it was their third championship.
The competition's champion earns a spot in the FIFA World Club Cup.
CONMEBOL Copa Libertadores
The most popular national club league outside of UEFA because it enjoys the same level of prestige. As of 2022 the current champion is Independiente from Argentina.
The top football clubs in North America, Central America, and the Caribbean compete in the CONCACAF Champions League, an annual continental club football competition, which is run by CONCACAF.
The CONCACAF Champions League champion earns a spot in the FIFA Club World Cup.
Due to Scotiabank's sponsorship of the event, it has been officially named as the Scotiabank CONCACAF Champions League beginning February 2015.
The top men's club football league in Oceania is the OFC Champions League, usually referred to as the O-League.
The Oceania Football Confederation (OFC), Oceania's football governing body, is in charge of organizing it. It has been running in the present format since 2007, taking after the Oceania Club Championship.
OFC Champions League Trophy @SKYCITYAkl Atrium – Welcome Tour FIFA Club World Cup Morocco 2013 pic.twitter.com/iyki2GLZyD
— Auckland City FC (@AucklandCity_FC) October 26, 2013
Papua New Guinea and New Caledonia are the only Pacific countries to have won the OFC Champions League, with 12 titles going to New Zealand-based teams.
Category Featured Hot Football/Soccer News News World Cup 2022 Tag CONCACAF Champions League Fifa FIFA Club World Cup FIFA World Cup Football News UEFA UEFA Champions League UEFA Europa League UEFA Nations League
← Emiliano Martínez saves two penalties to push Argentina and Lionel Messi to the Semi-final In Qatar
Portugal Players Questions Why Cristiano Ronaldo's Manager Joins The Team's World Cup Entourage →
Gianluigi Buffon disputes World Cup 2022 speculation and claims he has not set a retirement date
Rio Ferdinand and John Terry fight dirty on Twitter over the greatest Premier League center-backs of all time
Harry Maguire sentenced to jail and expected to serve 21 months and 10 days suspend Jail time
Eric Bailly Expressed Gratitude to Manchester United after joining Marseille
Official: Tottenham Hotspur are Premier League title contenders
FC Bayern lucky to sign Nigerian footballer, Daniel Francis.


text:
Duca del Cosma signs Dutch tour star Joost Luiten
6-time European Tour winner to wear Italian brand's distinctive footwear
Italian golf fashion brand Duca del Cosma today announced the signing of Dutch European Tour star Joost Luiten to wear its hand-crafted leather shoes in a multi-year deal from 1st January 2021.
A six-time winner on the European Tour, Luiten is the first global Tour player to be signed by the fast-growing brand, which is now based in Amsterdam under the stewardship of former HI-TEC owner Frank van Wezel.
(Photo: Duca del Cosma)
"The signing of Joost is a major statement by the Duca del Cosma brand and will give all our stockists a boost as they present this year's exciting ranges to their customers," said Frank. "Having one of the world's top-ranked players wear our latest models will make a significant difference to the brand's profile – not just in Holland and across Europe, but in all 30 countries where Duca del Cosma shoes are sold worldwide," he added.
The first Dutch player to win his national Open title twice (2011 & 2013), Luiten will be playing in the latest waterproof soft spike shoes and sneaker-style spikeless models this coming season. All the premium shoes in the Duca del Cosma golf range are designed exclusively in Italy by Creative Director Baldovino Mattiazzo – creator of the first spikeless golf shoe in 2006 – and manufactured in Portugal.
"I'm very proud to be wearing attractive and comfortable Duca del Cosma shoes that are designed and made to such a high standard in Europe," said Joost, who qualified for the European Tour's season-ending DP World Tour Championship in Dubai. "The brand's connection with The Netherlands makes it even more special for me and I can't wait to promote these distinctive shoes on Tour - both on and off the golf course," he added.
The 34-year-old will be hoping for a hat-trick of KLM Open wins next September when competing at the Bernardus Golf course. The Duca del Cosma brand has been a high-profile sponsor of the KLM Open since 2018 and will once again provide footwear to hundreds of volunteers and officials at one of the most popular events on the European Tour.
In total, Luiten has eight tournament wins since turning professional at +5 in 2006 and won more than €12m in prize money. His victories have come in France, Austria, Malaysia, Wales and Oman, where he won his last title in 2018 at the inaugural NBO Oman Open. He represented The Netherlands at the 2016 Olympics and in three World Cup contests.
Details of the latest Duca del Cosma ranges can be found at www.ducadelcosma.com
For further information, please contact John Collard at Sports Impact on +44 (0)208 549 5500 or at johnc@sports-impact.com
Assets (images, video's and logos) for publication via this link: https://drive.google.com/drive/u/0/folders/1xj4u7cpUxw7iuJ5zPg-1JgBZfTym3K2L
Industry NewsDuca del Cosma


Yesterday was sunny and warm, almost a summer day, with temperatures in the high 20s C/~80F and the right proportions of sun and clouds.
Today is chilly, cloudy, rainy, with temperatures in the 40s and 50s. Fog is rolling around out on the bay.
My life in 2015, so far, has had a lot of weather-like changes. Ups and downs, sunny and rainy/snowy/sleety/foggy, "yes" and "no," the occasional "maybe" and "okay" and "just fine," too.
Enough walks along leaf-strewn paths to help me get over--sort of--the significant stumble that sprained my ankle, or the pain from the book I recently dropped on that sprained ankle.
Enough chores and delights that I don't have to keep raking, thereby exacerbating the giant thumb blister I developed last week that has burst and become really sore.
And there are writing-type events for which the above walks and chores serve as metaphors.
Even with all the weather-esque changes, our lives' climate is seasonal and enjoyable--reasonable health, some interesting work, projects finally wrapping up, new and enchanting projects brewing. Life is still relatively normal, or within shouting distance thereof.


text:
How to remove video using the webcam simply sitting in front of computer and talking. Before that you need to become familiar with the software for video editing, as well as the functionality used by the web camera.
How to connect a joystick to the computer
How to set a webcam in the laptop built them into the case. Users of these laptops no need for special configuration. But sometimes owners are not satisfied with the quality of the built-in camera, and then sold the individual you need to properly install and configure. As a rule, no major settings for normal web camera is not provided with this task can handle virtually any user.
What to do if not working mouse
How to connect a web camera to the computer
How to connect Xbox joystick to PC
How to run games on ps3 hard drive
How to connect the speakers to the computer , usually not particularly difficult. But connecting the speaker system has a number of difficulties and few solutions. For a successful connection is acquainted with the technical capabilities of the sound card.
How to find a driver for your network card
How to connect wifi router to laptop
How to turn on Acer webcam
How to set up your microphone and headphones into the computer and headphone (headset). From their proper setting depends on whether you communicate via computer with other Internet users or not.
How to set microphone in webcam
How to download photos from the camera to the computer from memory digital camera sooner or later must be downloaded into a computer, as the stocks of any medium is limited. To download photos from camera to computer in various ways.
How to set speakers on computer
How to make sign on the keyboard
How to connect home cinema to PC for many much easier than on the TV screen. While no one will refuse from high-quality and powerful sound that can not give the computer speakers, but that gives the home theater equipment. Usually a home theater connects to the TV – but you can combine high-quality sound and viewing movies and listening to your favorite music on the computer after connecting a speaker system home theater system (5:1).
How to connect MTS modem company MTS – the device is light, compact and versatile. Some models of modems have slots for memory cards so you can use them not only for web surfing, but also for transferring files. And set the modem to the computer and connect with it to the Internet I can even a beginner. The only condition is that you must be in the coverage area of MTS.
How to restart your router
How to use the camera on the computer has become a necessary and popular accessory with the popularity of video telephony services. Its scope is wide enough not only transfer images but also video conferencing, computer games, video surveillance. Modern camera also produces video compression and image transmission and has a fairly complex device. And although the treatment problems arise infrequently, but there are difficulties with the connection (such as an inverted image) and installing the drivers.
How to adjust volume on the keyboard
How to know if the bluetooth on the computer
How to install network controller . Also Ethernet controller is required to connect to some wireless networks. We are not talking about connecting devices to the system Board, and its inclusion in the system.
How to set mouse to single click
How to throw music on a USB flash drive


After such a long goodbye — it began 'formally' we think at Easter, it has come as something of a surprise to realise that it's now over a month (interestingly exactly 40 days) since we arrived in our new home.
150+ packing cases are reduced to zero and a dozen or so plastic crates are down to 3 (one containing a 'rubber' dinghy — bought many, many years ago whilst on holiday in Cornwall and now retained just in case we have 40 days and 40 nights of rain this coming winter!!). A place has been found for most things — although some are housed temporarily until our garden shed is built. Charity shops in Alton and Langport have been showered with our surpluses and the click-path to eBay has been well fingered, although some bargains remain.
The weather has been wonderfully kind making the unpacking, sorting and sundry DIY tasks not only easier but positively (well, mostly) pleasurable.
Of course there's much still to do but we are comfortably installed and feel that we can now take most of what remains to be done at a more gradual pace. The garden is the coming project — it could (or perhaps will) take a lifetime.
But all work and no play is good for no-one and we have been busy enjoying ourselves — with trips back to Alton for friends' silver wedding; a couple of visits to Chester to help get Anna and grandson Finlay's house ready for moving in (in fairness more work than play but still very satisfying); the Parish fete at Huish Episcopi (village 1.5 miles away) in a very impressive vicarage garden; the Muchelney Village Fete — tents to erect and take down, bric-a-brac to sell and a children's prize game to manage, all on Bank Holiday Monday; the weekend following the Drayton (village 2 miles distant) Street Fair on the Saturday, but most important of all a special Deborah birthday weekend celebration for which daughters Sophie, Olivia and Laura plus Ruaidhri (Sophie's fiancée) made the trip from London and Alton — a wonderful day filled with laughter, fine food and brilliant sunshine, a great first family visit home.
We've yet to make it to the local Methodist Church in Kingsbury Episcopi (village 3 miles from home) but it's definitely on the schedule for this coming Sunday — we've visited before the move and we were made to feel very welcome so we are looking forward to returning.
We are very much looking forward and not over our shoulders but of course our business still needs Deborah and she travels back for 3 days every week — it's a pity but there is no immediate option at the moment, so we still have strong links — but we miss all our friends in Alton. You all have an open invitation to come visit or call in — a warm welcome awaits all who make it here.


text:
Updated / L.A. Noire delay confirmed
Update: L.A. Noire gameplay 'revolutionary, never before seen in the industry'
Update 2: Why was L.A. Noire delayed?
Original story: Take-Two has just confirmed the delay of Team Bondi's L.A. Noire.
Retailers last week were certain of a delay to "well into [fiscal] 2011." It's also been a while since we've seen anything new from it.
The crime title is now expected "during the first half of calendar 2011," the publisher's third quarter fiscal 2010 financial results say. It was previously expected some time this fall.


text:
The royal chefs have released their official gingerbread house recipe
By Ash Kent| 4 weeks ago
I'm not sure about you, but I often wonder what it would be like to dine in Buckingham Palace, or in any of the Queen's other residences for that matter.
It is not very often that we get an actual insight into what really happens behind palace walls — apart from the odd rumours from royal insiders.
But royal fans have been treated with a gift that makes 2020 just that little bit sweeter, with royal chefs sharing their gingerbread house recipe on The Royal Family website, along with a cute how-to video via the official Royal Family Twitter account.
"In the run up to Christmas, the chefs in the Royal kitchens have shared their recipe for making the perfect Gingerbread House. Here's all the information you should need to make the house yourself at home," the Royal.uk website reads.
The recipe also contains a downloadable PDF template fans can follow to trace the shape of the house.
The clip also demonstrates the intricate art of piping the 'royal icing' in the beautiful shapes designed by the chefs, with a little note from them asking fans to share their finished products with the hashtag #RoyalGingerBread.
The Royal Family's former chef between 1982-1998, Darren McGrady, has said in the past that the menu at Sandringham on December 25 is traditional and always involves turkey.
McGrady, who worked for the Queen and Princess Diana, told Hello! Online that the royals are actually "pretty boring" when it comes to the Christmas menu, saying the only meat they serve is turkey.
"They didn't do hams or anything, just traditional turkeys," McGrady explained. "We did three turkeys for the Queen and her family in the royal dining room, one for the children's nursery and then more for the 100 or so staff, so everyone had a Christmas lunch."
Well if it's good enough for the Queen...
The best boozy Christmas drink according to your star sign
Auto news: Electric Mustang ute rendered: What if Ford turned out a Mach-E pick-up? - caradvice.com.au


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Access control systems leader TDSi appoints three executive members to its UK team
TDSi, a global leader in access control systems for all sizes of businesses and organisations has recruited three new members to its UK team. Rob Clark joins as Business Development Manager for the company's VUgarde IP video surveillance solution, Francesca Wilkey is appointed to the role of Customer Care Advisor, supporting TDSi's partners, resellers and end-users, and Greg Little has joined in the role of Pre-sales Support.
TDSi's VUgarde provides a fully featured suite products, which operate in a stand-alone mode or as part of a fully integrated system, complementing its range of access control products and systems. As the new Business Development Manager for this suite, Rob Clark brings to TDSi a proven pedigree in IP video surveillance, following sales roles at Sony UK Ltd and Mitsubishi Electronics. Clark comments, "I'm excited to join TDSi and work with VUgarde to provide a fully integrated system to meet the most stringent security and surveillance requirements of any organisation."
Francesca Wilkey joins TDSi's product support team from Siemens Mobility and has a background in technology customer service. Wilkey comments: "TDSi has a reputation for delivering top-notch customer service and I am looking forward to making an important contribution to helping our partners, reseller and end-users get the very best from their TDSi systems."
Greg Little takes on the role of Pre-Sales Support having also previously designed CCTV and access control systems for Chubb. Gregg has a crucial role assisting in the quoting process and bridging the gap between the TDSi Sales teams and Technical Support team. Little comments, "This is an exciting opportunity to be at the heart of TDSi's customer support. The company has an excellent track record of quality products and well-tailored solutions and I am very pleased to be part of the on-going success.
Managing Director at TDSi, John Davis states: "We welcome Rob, Francesca and Gregg to the TDSi team. We are delighted that the company is able to attract people of their calibre and I am sure that their expertise and enthusiasm will make a vital contribution to the company and those who use our systems."
Rob Clark, Francesca Wilkey, Greg Little are based at TDSi's global head office in Poole, UK.


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Hope amid the horror
Kola Ogundiran (left) and Pascale Armand rehearse a scene from La Jolla Playhouse's "Ruined."
(Peggy Peattie)
Playwright injects a note of optimism into Pulitzer-winner 'Ruined,' a tale of wartime atrocities in the Congo
By James Hebert
It is a moment of defiance in a place of degradation and despair. A young Congolese prostitute, a survivor of unspeakable violence, dares to speak of it to the men making war:
"You will not fight your battles on my body anymore."
Battles of all kinds — tests of wills, clashes of conscience, private fights to salvage a shred of dignity — erupt in "Ruined," Lynn Nottage's Pulitzer Prize-winning play about the chaos visited upon lives in Central Africa.
And combat in a more literal sense unfolds during a midday rehearsal at La Jolla Playhouse, which this week launches one of the first West Coast productions of the work.
On one side of the room, performers portraying a bar girl and a menacing general run through a scene in which he roughs her up like a rag doll; on another side, two actors grapple fiercely as they play feuding soldiers.
When each take is over, though, the stressed but stoic cast members shrug off the aggression. Director Liesl Tommy gives actor Carla Duren a motherly hug. Smiles begin to break the strain. The next rehearsal scene, set around a wistfully pretty song Duren performs in the bar, eases the mood a bit more.
That sense of light shining through gloom goes to the bruised heart of "Ruined," set in a makeshift watering hole and brothel in the Democratic Republic of the Congo, a country ripped apart by civil war.
Nottage and Kate Whoriskey, who directed the original staging of "Ruined" (and is a onetime Playhouse artistic associate), traveled to Africa in 2004 to interview women who had survived the epidemic of rape and torture spawned by the Congolese war. Those accounts formed the bedrock of this difficult, unflinching drama. (Its title refers to females who have been sexually mutilated, typically by bayonet.)
But "the miracle of the play," says director Tommy, is that amid such atrocities, Nottage manages to inject a note of hope, some flashes of humor, even the stirrings of a love story.
"It's the brilliance of her writing, that she can find a way to incorporate romance into this world," Tommy says with a small laugh of disbelief, as she chats during a rehearsal break. "And it works. You become totally engaged in that alternative journey these characters are going through."
Tommy speaks of a pivotal scene near play's end, when the tale seems to teeter between redemption and calamity, and of how Nottage's richly drawn characters invest the moment with suspense.
"Even those of us who knew the story (wondered), 'What's going to happen to these people?' " she says of an early read-through. "Not what's going to happen to the Congo, not what's going to happen to the war, but what's going to happen to these people?"
That same scene happens to have earned Nottage some critical flak, even amid the great acclaim for "Ruined," which premiered at Chicago's Goodman Theatre in 2008, moved to the off-Broadway Manhattan Theatre Club in early 2009 and was named the Pulitzer winner that April.
The playwright wears the sniping over her work's coda of uplift as a badge of honor. Her aim, she says, was to distill the unfathomable tragedies of the Congo into a work of compelling theater, not a ranting polemic or an expression of resignation.
"I spent a lot of time thinking, 'How am I going to tell a story that's essentially a political story, that's essentially didactic, for an audience that's coming to the theater to see a narrative (drama)?' " Nottage says by phone from New York.
She fully expected blowback over the result.
"For me, absolutely, I consider it my radical ending. The fact there's controversy around it shows that it isn't the typical, (expected) ending. I knew I was going to get rapped in the knuckles."
To those doing the rapping, though, Nottage is happy to offer a response that amounts to "Forget them!" (Only not quite so printable.)
"Ruined" is patterned loosely on "Mother Courage and Her Children," the landmark 1939 Brecht play about a matriarch who strives to make a profit from wartime. Her counterpart in "Ruined" is Mama Nadi (Tonye Patano of TV's "Weeds"), the bar's no-nonsense proprietor and madam.
As the mama of this singular play — her most successful in a string that includes "Intimate Apparel," "Fabulation" and "Crumbs From the Table of Joy" — Nottage says she's entirely comfortable turning it over to Tommy.
One reason is the director has staged "Ruined" before, in a recent production at the Oregon Shakespeare Festival. Another is that Tommy spent her earliest years in apartheid-racked South Africa, so knows the continent and its crises.
"There is a moment when you feel your baby is fully developed, and it's safe in the hands of others," says Nottage. "And there are (other) moments when it makes me incredibly nervous."
This time, though, Nottage feels confident that "something wonderful will be put onstage. I think (Tommy) will bring a very special texture to the play, from having spent time on the continent and having a special love for the continent, and for the stories that sort of flow from there."
The Playhouse is co-producing the work with Berkeley Repertory Theatre and the Huntington Theatre in Boston. Whoriskey herself directed the West Coast premiere of "Ruined" earlier this year at the Intiman Theatre in Seattle, where she is artistic director, and in Los Angeles. (Whoriskey and Nottage share a mentor in former Old Globe co-artistic director Jerry Patch, who first teamed them at South Coast Rep in Orange County.)
Considering the devastation of the Congo war and the scope of the ongoing sexual violence there, the situation has received relatively little attention abroad. But that seems to be changing.
Nottage says "Ruined" has been "part of a tipping point. I like to think it has made an impact. We've been able to do incredible fundraising around the play."
True to the ultimate spirit of "Ruined," Tommy allows herself some optimism as well. She has seen change in Africa firsthand: Her mixed-race family fled South Africa in the 1980s, but after apartheid fell, her father was invited back as a high-ranking city planner.
"What's just amazing to me is that finally I'm feeling that American audiences and (stage) producers are recognizing this is something that has meaning and interest for them, too," Tommy says. "It's not just something about "over there," for people over there.
"We're connected to these greater stories — these international stories."
jim.hebert@uniontrib.com • (619) 293-2040 • Twitter @jimhebert
In Congo, crisis grinds on
Lynn Nottage's "Ruined" is set in a small mining town in the Ituri rain forest, at the northeast corner of the Democratic Republic of Congo.
The nation has endured what seems almost unending war, with conflicts flaring among a volatile, shifting mix of militias, government forces and mutually hostile ethnic groups.
By some accounts the war has claimed as many as 5 million lives, counting casualties from starvation, disease and displacement. It also has come with an epidemic of sexual violence — 15,000 cases in the affected part of the country last year alone, according to the United Nations.
The way that kind of brutality fosters a sense of moral ambiguity is a key theme of "Ruined." It's personified in Mama Nadi, who hosts both soldiers and rebels in her makeshift bar and brothel, and considers the place a sanctuary for the women she puts to work as prostitutes.
"It's something we talk about all the time," says director Liesl Tommy. "The life there is so chaotic. But life in the middle of war anywhere is chaotic. If you've never lived through war, or been put in a position to make these extreme choices, it seems like Mars. It doesn't seem like Earth.
"That's what the play is about, is making sense of this behavior."
The director recalls a moment when Wendell Franklin, who portrays the rebel leader Jerome Kisembe in the La Jolla Playhouse production, told her that "'the hardest thing about this is shifting your idea of manhood from being a protector to being a destroyer.' He was really struggling with it. They all were."
JAMES HEBERT • U-T
La Jolla Playhouse
When: In previews. Opens Nov. 21. Schedule: Tuesdays-Wednesdays, 7:30 p.m.; Thursdays-Fridays, 8 p.m.; Saturdays, 2 and 8 p.m.; Sundays, 2 and 7 p.m., through Dec. 19.
Where: Playhouse's Mandell Weiss Theatre, UCSD campus
Tickets: $31 to $66
Online: lajollaplayhouse.org
James Hebert
Curtain call: Looking back on a dozen years in the life of a theater critic
As he departs the Union-Tribune, James Hebert assesses what he has seen and looks to what's ahead for San Diego's stage community
A look at San Diego-area theater companies' latest online offerings
La Jolla Playhouse, OnStage Playhouse and Scripps Ranch Theatre/Oceanside Theatre announce online interviews, readings and more
San Diego Rep's canceled 'House of Joy' rises again, as a full-length recorded video
Theater's staging of Madhuri Shekar play, which was recorded during dress rehearsal, is now available on Vimeo
Choreography session today by team from Tony-winning show is part of La Jolla Playhouse online offerings
Kelly Devine and Ricky Hinds of "Come From Away" hosting program; theater also announces "LJP Vault" series
From the arts front lines: Jacole Kitchen still 'figuring out how to adjust to this new version of normal'
Jacole Kitchen is artistic programs manager and local casting director for the La Jolla Playhouse.
From the arts front lines: Vanessa Dinning: 'I'm very angry at COVID-19. It took me a while to realize it, but I'm mad'
'I miss people. I miss hugs. I love to collaborate. Nothing beats the energy that comes from a group of creative people getting together to make magic happen. '


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Microsoft crowns its Edge browser the winner over Chrome in a battery life battle
By Kyle Wiggers	 June 20, 2016
Have a Windows laptop that's experiencing battery woes? Chrome is the likely culprit, alleges Microsoft. In a blog post published Monday to the company's Windows blog, the Redmond, Washington-based firm detailed the results of battery tests that found its browser, Edge, reigning supreme, and showed Google's open-source alternative draining more power than the competition.
Microsoft conducted three separate tests over a period of weeks, said Microsoft's Web Platform Team director Jason Weber: one that measured the power consumption of popular web browsers — Mozilla Firefox, Edge, Chrome, and Opera — in a "controlled lab environment," a second that used "real-world energy telemetry" from "millions" of Windows 10 machines, and a third that focused solely on battery longevity.
The lab test involved connecting a Surface Book to "specialized power-monitoring equipment," Weber explained, to measure the laptop's instantaneous power consumption as it ran tasks meant to approximate an average user's browsing session. After hours of video streams, tab switching, and navigation of sites like Facebook, Google, YouTube, Amazon, and Wikipedia, Microsoft collected enough diagnostic data to correlate power draw "to the energy consumed by the machine." The result? Edge used just 2,068 milliwatts of power during peak workload — less than the 2,819mW Chrome consumed and the 3,077mW and 3,161mW Opera (on battery-saver mode) and Firefox drew, respectively.
"Our tests show that Microsoft Edge is a more energy-efficient browser on Windows 10," said Weber. "We designed Microsoft Edge from the ground up to prioritize power efficiency and deliver more battery life, without any special battery-saving mode or changes to the default settings. Microsoft Edge is built to maximize the potential of your hardware to operate efficiently on daily activities, while using minimal resources when a page isn't being used."
The second test involved "billions" of real-world data points collected from Windows installations from around the world. Microsoft used the Energy Estimation Engine (E3) service, which monitors the internal power draw of battery-powered Windows 10 devices. Within that data set, Edge eked out an even larger battery win over the browsing competition: with a measured average power draw of just 465.24 mW, it bested Chrome's (719.72 mW) and Firefox's (493.5 mW) numbers by a noteworthy margin.
Microsoft's final test saw video streamed across Firefox, Edge, Chrome, and Opera — the company ran the same looped, high-definition video on four Surface Book devices, each running a single instance of a browser, until all of the devices died. Edge lasted three hours longer (7 hours and 22 minutes) than the worst performer, Chrome (4 hours and 19 minutes), two hours longer than Firefox (5 hours and 9 minutes), and an hour longer than Opera (6 hours and 18 minutes).
Those numbers aren't implausible. In a battery longevity test across Edge, Firefox, Opera, and Chrome, Digital Citizen found that Edge lasted the longest (and Chrome the shortest). And a recent Wall Street Journal test arrived at the same conclusion, Weber pointed out. "Our testing and data show that you can simply browser longer with Edge than with Chrome, Firefox, or Opera on Windows 10 devices," he said. "People using Microsoft Edge simply get more out of their battery every day."
But the battery prowess isn't Edge's alone, and Microsoft acknowledged as much. The next major Windows update, Windows 10 Anniversary, contains a number of battery-focused improvements that should see battery life gains across devices and software. Background tabs in Edge use fewer CPU cycles, for one, and networking tasks are executed a bit more expeditiously than they are currently. "These improvements will build on the efficiency demonstrated [in the tests] to make sure you can stay online longer with Microsoft Edge," said Weber.
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Tatehana Wharf Morning Market | Awakening with the rising sun, the most vivacious market in Japan.
the most vivacious market in Japan.
As dawn breaks, the Tatehana Wharf Morning Market comes alive. Over 300 stalls line the 800-meter stretch of Hachinohe Port, selling some of the freshest produce in Aomori Prefecture. With tens of thousands of shoppers every week, the morning market is not only one of the largest in Tohoku, but in all of Japan.
The market hosts a rich variety of goods, from the area's famed fresh and dried fish, to vegetables, fruits, flowers, sweets, bread, cutlery, antiques and more. Traditional coffee shops and udon noodle restaurants serve up hearty breakfasts for early-morning shoppers against the gorgeous backdrop of Aomori's Pacific coast.
About 10 minutes on foot from JR Mutsuminato Station.
Approximately one hour as a guide if you look around slowly. You can enjoy eating while walking an enjoying the scenery such as bread and also side dishes from popular shops.


have seen first hand, how effective salt therapy is for middle ear infections in kids. Our 4 year old had an undiagnosed one, which lingered and flared up and down continuously throughout his first year of preschool. His speech was fine and always had been, but he seemed glum and had lost his mojo – my little boy just wasn't quite the boy he normally was.
I had his ears (and general health) checked often. His general health was usually fine, and mostly his ears were diagnosed as perfectly fine too. abhibus coupons Sometimes there was a little fluid in them, though nothing to worry about I was told. He rarely complained of his ears hurting, but seemed to have developed selective hearing, though only on the odd day here and there. Occaisonally he would talk of a 'buzzing' or 'popping' noise he could hear, which the rest of us could not (obviously the trapped mucous bubbling away in his ear). One thing he hated, which in hindsight I can completely understand, was putting his head under water. Infected ears have enough pressure in them without adding more by way of extra water.
Over those months, I treated him with all manner of things. Naturopathically, I boosted his immune system with everything at my disposal. I used probiotics, herbal medicine, vitamins, minerals, tissue salts etc. All of which would see the return of most of his mojo – only for it to completely disappear again over the following weeks after finishing treatment. It wasn't until I took him to a hearing test that the audiologist suggested that his results were indicative of a middle ear infection, or glue ear as it's often referred to. I was firmly told that audiologists do not diagnose (just so you're sure as well!), but for me, that was enough of a 'diagnosis' to justify an intensive course of salt therapy sessions to see if it would help.
We had already been doing random salt sessions here and there, mostly with the intention of boosting his immunity, but I increased these to every couple of days. He had around 10 sessions in 3 weeks.
I won't ever forget the moment (after our 6th session) when I heard his hearty belly laugh come flooding in from the back yard – it brings a smile to my face just writing about it! My husband and I looked at each other with absolute glee knowing that our boy's mojo was COMPLETELY BACK! Yeeehaaaa!
I possibly could have stopped at session number 6, but I felt more comfortable going for a few more – kind of an insurance policy to ensure that it really and truly had disappeared. We'd been troubled on and off for months so a few more sessions for absolute peace of mind were nothing but a welcome relief. In those last few sessions, my boy kept telling me that he felt great and that we didn't need to go for more sessions – I have to admit, his mojo was seriously back too, but mums (generally!) have the last word though huh?
After many months of trying all manner of things, the salt therapy had managed to completely dry up the troubling, trapped mucous from within his ear. The salt would also have killed off any lingering infection due to its antibacterial nature. The naturopathic medicines I'd had him on should have killed off any infection too, but as the mucous hadn't been completely drained and dried, it'd leave behind an opportunistic environment for whatever other bugs were lurking and waiting for him at preschool – and the merry go round continued! Not much can be done about quietly lurking bugs, and in fact – they are good. Kids immune systems learn that way.
I understand that being the owner of a (soon to be opened!) salt room, people would expect nothing less than a positive testimonial on it. As a mum to a little boy though, I honestly and wholeheartedly offer my own experience in the hope that it may help others whose children are suffering similarly vague symptoms and more importantly, a serious loss of mojo! Salt therapy is a non invasive, natural treatment, and most importantly, it's fun for kids – they love playing in a salty adventure playground!
I wouldn't hesitate in recommending salt therapy for kids with middle ear infections. For my family, the results were dramatic in a very positive way.
← Himalayan salt – the salt of the gods..


Masala is one of the most exciting, intense and mystical range of designs from Gottex, from this year or any other. As the name suggests, its beauty comes from the East, with elements taken out of all the empires from Ottomon to Mughal. It is rich and dense and infinitely detailed, and like all GTX items from Gottex, it is aimed at giving you some of the most beautiful, chic and youthful designs possible. If this kaftandoes anything, it does exactly that, offering you a spirited and timeless look and a colourful vitality that only the young at heart can truly appreciate.


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Volvo Full Roof Rack Panoramic Sunroof
Used Volvo with Full Roof Rack and Panoramic Sunroof
Reviews for Volvo
Fun and dependable car at fair price
Great car for my wife and daughter to drive around town. The car gets reasonable gas mileage and has been trouble free in the 4 short months that we've owned it. We live in Oregon and I would have never considered a convertible but being a hard-top convertible you get the best of both worlds.
- R Anderson, 2009 Volvo C70
Last Of The Iconic Volvo's
The S90 is the last remaining iconic rear wheel drive Volvos produced and the 1998 model year was its swan song. The S90 production was only about 18 months. This model not only competes very well with its European cousins such as Mercedes, BMW and Audi but excels in overall fit, finish, performance and reliabilty. The S90 has such understated elegance, that belies its true heritage. Make no mistake it is a true Volvo with safety a paramount issue and was the first to employ side air bags in this model year. Although some 17 years now into service, not many are available in the pre owned market. Many of the S90's were used as transportation for royalty, diplomats, executives and UN duty the world over based upon the safety measures.
- Ned Abbott, 1998 Volvo S90
Nice car for family
It feels heavy and strong, and safety rating is good. The handling is not that responsive compare to other cars I have, but it runs more stable on highways at higher speeds. Large cargo space make it our preferred car for longer distance family trips.
- Ryan Lai, 2011 Volvo XC90
Top 10 Convertibles Under $20K of 2016
Fri, Nov 18, 2016Buying a Car
Nothing compares to the feeling of the wind whipping your hair back as you cruise in a well-built convertible. Well, almost nothing—the feeling of getting a great deal on your vehicle purchase is definitely a close second. You can enjoy both of these awesome sensations at the same time by selecting a high-quality convertible that sells for less than $20,000.
Best Luxury Compact SUVs: Reviews, Photos, and More
Tue, Sep 18, 2018Rankings
A compact luxury SUV gives you the added passenger and cargo space of an SUV with the extravagance of a luxury vehicle. CarMax's list of the top seven best luxury compact SUVs is a great place to begin your search.
40 Refreshed or Updated Cars for 2017
Fri, Jan 20, 2017Trends
Henry Ford once famously told customers that his Model T came in any color they wanted, so long as that color was black. That was over 100 years ago. Today, the vehicles available to us come in a variety of colors, shapes, and sizes, with a profusion of available options and features. Whether you're shopping for a quality used vehicle, or you want to take the plunge with a new car, 2017 is a great time to see what's available.


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La tRNA (guanina-N7-)-metiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione:
S-adenosil-L-metionina + tRNA  S-adenosil-L-omocisteina + tRNA contenente N7-metilguanina

Bibliografia

EC 2.1.1

redpajama_set_name: RedPajamaWikipedia


Immerse in the local life of a traditional fishing village. Welcome to the homestays of Franco and Alhagie, two brothers. Get a peek into their daily life and have the opportunity to exchange stories.
The houses are located at the edge of Tanji. You can pick the homestay you would like to stay. Both offer you a double bedroom with shower and toilet. You have the option to join for lunch and/or dinner. The wives of Franco and Alhagie will be happy to prepare a delicious home cooked meal for you.
Hello, we are Franco, Alhagie Saho. We are born in Jakaba in Gambia's countryside. At a very young age we started looking for a better future for our family and ourselves. We have worked in a guesthouse for some time where we have met many people from around the world. This has taught us a lot. Ten years ago we got in contact with a couple of people from the Netherlands. With them we have set-up several projects with the goal to give children a chance to build a future. Franco speaks English and Dutch and Alhagie speaks English. We would love to show you our Gambian way of life and to learn from each other. We are looking forward to welcome you!
Great place to stay - we had a wonderful 3 nights here. The food was great, everyone was very flexible, there was plenty of advice about what to see and where to go. Tanje is a great place to explore with an amazing fishing beach and great museum, catching taxis was easy from near the house and Franco was always willing to arrange transport as well. The accommodation was very good and very comfortable with plenty of space for the 5 of us.


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Posted on July 11, 2016 November 16, 2016 by Angry Staff Officer
Skywalker on Trial: the Galactic Code of Military Justice
Scene: Galactic Courtroom. Defendant seems blissfully unaware of what's going on, keeps talking about his training with a "Yoda."
Judge: "Commander Skywalker, let's walk through the events that occurred during the Battle of Hoth, shall we?"
Commander Skywalker: "Sure, it's all the same to me, but I'm kind of busy and –"
Judge: "Commander, this is a military organization, and we have rules. General Carlist Rieekan ordered us to convene an investigation into your actions that day, as per the Galactic Code of Military Justice. The better part of Rogue Squadron was wrecked, our ground forces scattered, and we barely escaped with our transports. Now, you were the commander of Rogue Squadron that day, were you not?"
Commander Skywalker: "Yeah, I was."
Judge: "And what were your orders?"
Commander Skywalker: "Well, we got word that there were Imperial forces landing and I grabbed Wedge – I mean, Commander Antilles – and we got the squadron and we flew out–"
Judge: "Yes, yes, Commander, I meant, were you delivered orders through a specific orders process, with commander's intent, overall mission and execution?"
Defendant stares quizzically at Judge.
General Rieekan: "Um, sorry your honor, but my staff was a little busy packing up, and I don't really like operations orders anyways, I like to use mission command on the fly, so…."
Judge: "Very good, sir, I see. Well then, commander, you then sortied out of the hanger. What happened next?"
Commander Skywalker: "Well then we flew over our lines and towards the Imperial AT-ATs, we passed them, and then I gave the order for attack pattern delta and–"
T-47 Speeders on approach…straight at the AT-ATs. (Lucasfilm, Ltd.)
Judge: "I'm sorry, did I hear you correctly? You deployed your T-47 Speeders over the top of your own troops in line formation? Rather than coming in from the flank? Putting all your ships on line together towards the main guns of the enemy armor? Main guns that can only fire forward, i.e., your direction of travel? And only after you passed the first walkers did you decide to assume a much less risky formation, attack pattern delta?"
Commander Skywalker: "Uh, yeah, it's what we do in our doctrine."
Judge: "So you use tactical doctrine, but don't use the orders process? Hm." Makes note. "Very well then, what happened next?"
Commander Skywalker: "Then we started making passes on the AT-AT's, but their armor was too thick to penetrate with blasters, so Wedge managed to use his tow cable to tangle up one of them and bring them down. Then I tried the same thing but that's when our speeder was hit and my co-pilot, Dak Ralter, was killed."
Judge: "Ah yes, Dak. We'll come back to that. During your squadron's attacks on the enemy armor, did they at any time cross in front of the enemy main guns?"
Commander Skywalker: "Well, yeah, I think it happened a few times."
Judge: "Speaking with ground survivors, your aircraft passed in front of the main guns of the AT-AT's no fewer than twelve times, which accounts for the majority of Rogue Squadron's losses. In fact, your orders, as recorded by in-flight monitors, were for everyone to 'keep it tight.' Commander Skywalker, are you familiar with the concept of tactical dispersion?"
Commander Skywalker: "You weren't there, you didn't see what it was like!"
Judge: "No need to get testy, commander, we're not trying to trap you."
Admiral Ackbar coughs and looks unsettled from his position on the bench.
What defeat looks like. (Lucasfilm, Ltd)
Judge: "Now Commander Skywalker, you mention that the weapons on the T-47's failed to penetrate the armor of the enemy vehicles. Would you say that this is a design flaw?"
Commander Skywalker: "Definitely, we were unable to gain superiority because of that. In fact, our clumsy and inefficient blasters should be completely redesigned."
Judge: "I see. We'll make a note of that, although I suspect that Research and Design Department won't be able to do much about it considering our budget was cut by nearly 100% when Alderaan was destroyed. But back to the matter at hand. As you were entering combat, did your co-pilot make any remarks?"
Commander Skywalker: "Yeah, Dak said something about how he had no approach vector and that he wasn't set."
Judge: "And having determined that your own co-pilot said that there were deficiencies in your own ship, how did you proceed?"
Commander Skywalker: "I think I told him that it was okay, but it was all in the heat of the moment, I don't remember."
Judge: "Your exact words were, 'Steady, Dak.' Did you do anything to correct to allow for your co-pilot to determine the fault in the equipment?"
Commander Skywalker: "Um, no."
Judge: "I see. Dak found further faults with the vehicle, did he not? Specifically, when you asked him to prepare the tow cable for deployment."
Commander Skywalker: "Yeah, that's right, as we went in on our final approach."
Judge: "His exact words were, 'Oh Luke, we have a malfunction in fire control, I'll have to cut in the auxiliary.' Which would seem to point out that there were significant issues in not only the maneuverability of the ship but with the weapons systems as well. How did you conduct preventative maintenance on your ship prior to this mission?"
Commander Skywalker: "I dunno, that's not my job!"
Judge: "Commander, we have limited ships. As I mentioned, we have pretty much no budget for spare parts. It is imperative that ships are maintained to the best of our abilities. It is clear that no maintenance was conducted on your ship, leading you to be combat ineffective once involved in battle. You then told your own co-pilot, 'Hang on, hang on Dak, get ready to fire that tow cable.' What happened next?"
Poor Dak. He deserved a better pilot. (Lucasfilm, Ltd)
Commander Skywalker: "Then we got hit and I crash-landed the speeder, dismounted, and headed towards the closest walker."
Judge: "How did your ship end up in the enemy's line of fire?"
Commander Skywalker: "It was on our approach with the tow cable."
Judge: "You elected to begin your approach vector around the front of the walker? Hm. All right, then you crashed, and your retrieved two items from your ship, a grenade and an obsolete weapon, is that correct?"
Princess Organa: "Leading the witness!"
Judge: "Fine, fine, a lightsaber. With these two weapons you proceeded to disable a walker, which demonstrates bravery that is highly commendable. In fact, in light of this bravery, and your subsequent courageous but foolhardy attempt to rescue Commander Solo, the court has urged me to look with kindness on your case. Were it up to me, Commander Skywalker, you would be cashiered to some backwoods corner of the Galaxy, maybe Tatooine, for your abysmal tactical performance and the destruction of our limited resources. I would also reprimand you for your negligence in the care of your own equipment, which led you to be manning a flying box during the engagement. However, since we have a severe lack of pilots, an impending operation to rescue Commander Solo, and are essentially desperate, it is the recommendation of the court that you are reinstated to your command. And promoted to general. God help us. Court adjourned."
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CategoriesMilitary, Star Wars TagsAT-AT, Battle of Hoth, Luke Skywalker, Military, Punishment, Snowspeeder, Star Wars, T-47, Tactics, UCMJ
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