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BCC, RFA signs financing agreement for Highway street lights
Minister of Local Government and Rural Development Kondwani Nankhumwa on Sunday (22nd May 2016) presided over the signing of a financing agreement between Blantyre City Council and the Roads Fund Administration (RFA).
Chalamanda and Malata checks hands after signing the agreement witnessed by BCC Chief Executive Dr Alfred Chanza
The K400 million financing agreement is part of road safety programme which the RFA is mandated to finance.
Under the project, the Council is expected to install street lights along the newly upgraded Masauko Chipembere Highway.
Nankhumwa said the signing of the agreement was a testimony of the role RFA was playing in developing the country's road infrastructure.
Mayor Noel Chalamanda said the Council cannot successfully curb theft and vandalism if the City is in the dark.
"Improved street lighting is widely thought to be an effective means of preventing crime. Indeed, residents in crime-ridden neighborhoods often demand that the lighting be improved and the general expectation is that improved lighting does indeed reduce crime," said Chalamanda.
RFA Chief Executive Officer Stewart Malata emphasized on the importance of the street lights outlining that they play a key role in creating a conducive and safe environment for the road users at night.
"We would like to appeal that there should be a sustained maintenance program for these street lights. If the council can put in place a proper and proactive maintenance programme for these street lights, the city will be assured of an efficient service," said Malata.
Under the agreement, RFA is contributing 90 percent of the project amount (K360million) while the Council is contributing K40 million representing 10 percent of the total project cost.
May 24, 2016	 in Default
Council in urban development management drive
Local Government minister tours projects


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New home for Corrections | News | Kawerau
Announcements, Kawerau New Zealand, New & Events, News
EAST Coast MP Anne Tolley opened the new Kawerau community probation site this month, built from two former state houses and refurbished by prisoners.
Department of Corrections spokeswoman Heather Mackie said the two buildings, pictured, began life as state houses and were partially renovated during a prisoner education scheme at Spring Hill prison, Auckland.
They were moved to the site on Onslow Street, next to the Kawerau Enterprise Agency, earlier this year, and staff moved into the building in July.
Invited members of the Eastern Bay community toured the new site. Morning tea followed the September 18 opening.
The former Kawerau site was little more than a large shed, but the new facility has a number of meeting rooms, a reception area, an open-plan office, back deck area and a large shed for the centre's community work tools.
Ms Mackie said the whole area was covered by security cameras as part of the site safety plan, and the building's interior was designed with safety in mind.
She said the site would service 200 offenders from Kawerau and further afield. It was spacious enough to host programmes and courses.
Behind the shed is a large, open grassed area that staff plan to transform into a vegetable garden. Next door are two empty glass houses and three seed raising areas for preparing plants for the garden.
The area was previously managed by Kawerau Enterprise Agency but leased to Corrections.
Food grown in the area will be taken home by offenders or donated to food banks and other community organisations – modelled on the practices of Poroporo and Park Road gardens.
Source: Whakatane Beacon

redpajama_set_name: RedPajamaCommonCrawl


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Focus on Small Business
Structured Approach
ICV Value Creation Tools
Past portfolio
ICV Capital Partners Promotes Zeena Rao to Principal
By Ic&vPa8rtn#er!s Comments are Off
NEW YORK, January 5, 2010 - ICV Capital Partners, LLC (ICV), a private investment firm focused on investments in smaller middle market companies, announced today the promotion of Zeena Rao from Vice President to Principal. Willie E. Woods, President of ICV, said, "The promotion is a reflection of Zeena's significant contributions to the firm where she has been involved in
American Alliance Dialysis Holdings, LLC
ICV PARTNERS ESTABLISHES DIALYSIS TREATMENT PLATFORM WITH ACQUISITION OF ATLANTIS HEALTHCARE GROUP PUERTO RICO, INC. Formation of American Alliance Dialysis Holdings, LLC in Partnership With Dr. Randall Maxey, Dr. Otegbola Ojo, and Ms. Ruby Harford Will Acquire and Build Operations in North America and the Caribbean NEW YORK, March 19, 2013 – ICV Partners (ICV), a leading investment firm focused
Interventional Management Services Announces Merger Of Leading Georgia Pain Centers
Combination of Interventional Spine and Pain Management and Comprehensive Pain Management Creates Southeast's Largest Pain Management Provider ATLANTA, August 27, 2014 – Interventional Management Services (IMS) announced today the combination of Interventional Spine and Pain Management and Comprehensive Pain Management, both Atlanta-based companies. The combination of the two practices expands Interventional Management Services' metropolitan Atlanta reach to 16 treatment facilities,
ICV Partners Completes Sale of Mallet & Company, Inc.
NEW YORK, August 8, 2016 – ICV Partners, LLC (ICV), a leading investment firm focused on investing in lower middle market companies, announced today that it has completed the sale of its portfolio company Mallet & Company, Inc., to Vantage Specialty Chemicals, Inc., a portfolio company of The Jordan Company, L.P. ICV invested in Mallet in 2010 in partnership with
ICV Capital Partners, Palladium Equity Partners Join Together To Acquire The Hilsinger Co.
NEW YORK, June 2, 2003 – Private equity investment firms ICV Capital Partners, LLC and Palladium Equity Partners, LLC announced today that they have joined with management to acquire The Hilsinger Company, L.P., a leading supplier of eyewear and eye care accessories in the United States and the United Kingdom. Terms of the transaction were not disclosed. Hilsinger, based in
ICV Partners Announces Acquisition of Outpatient Imaging Affiliates
NEW YORK, March 13, 2018 – ICV Partners, LLC, a leading investment firm focused on middle market companies, today announced the acquisition of Outpatient Imaging Affiliates, LLC ("OIA"), a leading provider of outpatient radiology services in partnership with leading health systems across the country. ICV acquired OIA from the company's founder, Frank Kyle and MedCare Investment Funds, a privately held
ICV Partners Establishes Dialysis Treatment Platform With Acquisition Of Atlantis Heathcare Group Puerto Rico, Inc.
Formation of American Alliance Dialysis Holdings, LLC in Partnership With Dr. Randall Maxey, Dr. Otegbola Ojo, and Ms. Ruby Harford Will Acquire and Build Operations in North America and the Caribbean NEW YORK, March 19, 2013 – ICV Partners (ICV), a leading investment firm focused on lower middle market companies, announced today that it has established a kidney dialysis treatment
ICV Partners' Safe Security Completes New $130 Million Credit Refinancing To Further Growth
Acquisition of Additional Pinnacle Security Accounts Doubles Revenues Since December Acquisition NEW YORK, March 11, 2013 – ICV Partners (ICV), a leading investment firm focused on lower middle market companies, announced today that its portfolio company SAFE Security successfully completed the refinancing of its existing senior credit facility with a new $130 million debt facility led by Bank of America.
ICV Partners Safe Security Acquires Monitoring Accounts From Pinnacle Security
NEW YORK, February 7, 2013 – ICV Partners (ICV), a leading investment firm focused on lower middle market companies, announced today that its portfolio company SAFE Security has acquired approximately 24,000 security alarm monitoring subscriber accounts from Utah-based Pinnacle Security. The newly acquired accounts represent $1.1 million of Recurring Monthly Revenue. "This is an exciting and important addition to SAFE's
ICV Partners Announces Acquisition of Cargo Airport Services
NEW YORK, April 5, 2011 – ICV Partners (ICV), a private investment firm focused on investments in smaller middle market companies, announced today the acquisition of Cargo Airport Services (CAS), a leading provider of innovative cargo handling solutions, from MidMark Capital, the Weinberg Bell Group and other shareholders. Chief Executive Officer Michael Duffy and the CAS executive team have also
ICV Partners Announces Investment In Beacon Global Strategies
ICV Partners Announces Sale of Outpatient Imaging Affiliates
ICV Partners Announces Majority Investment in Cherry Tree Dental
ICV Partners Fortifies Its Portfolio Operations Group with the Addition of Former Coca-Cola Company Executive Bill Ford
ICV Partners Announces Majority Investment in Total Access Urgent Care In Partnership with Management
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Sandeep Sood
5MF Issue 2: The Core Banking System
Innovations in computing and telecommunication technology made data available in 'real-time'.This is the essential ingredient of a core banking system. a centralized data center that distributed bank branches can access via software applications, in order to get real-time (or close to real-time) account information.
The year is 1968. You need to make a cash deposit. You put on your fancy 1968 outfit, complete with a stylish hat, and head to your local bank branch. The teller puffs on a cigarette and informs you that your account will reflect the deposit at all branches in 24 hours...if you're lucky.
This is life before 1970: awesome clothes, stylish vibes, no core banking.
What does the 'core' stand for?
This is the rare occasion in which an acronym works as a word and abbreviation.
Abbreviation: Centralized Online Real-Time Exchange
Word: Core banking systems enable the core services a bank provides.
What happened in the 70s?
Innovations in computing and telecommunication technology made data available in 'real-time' (in quotes, because updates were made via batch processing, so how 'real-time' you were depended on how often, or how automated, your batch processing system was).
This is the essential ingredient of a core banking system: a centralized data center that distributed bank branches can access via software applications, in order to get real-time (or close to real-time) account information.
Technologists built these systems on mainframe computers using early programming languages like COBOL. Fun fact: many of today's largest banks still run a significant portion of their systems via batch processing...and on code that was written back in the 70s (this is the exact opposite of a fun fact if it's your job to maintain these systems).
What are 'core' bank functions?
The definition of core banking varies depending on who you ask. Let's start with what seems to be the most widely accepted list:
Deposits (checking, savings)
The above list applies to both retail and commercial banking. Some banks include CRM (customer relationship management), regulatory reporting, and risk management in their definition of core banking, and others include specifically institutional functionality such as wealth management and money markets.
The Core Banking System Landscape
Most banks implemented their core banking systems years ago. These legacy systems, clearly an inferior choice in the era of cloud computing, cost the banks hundreds of millions of dollars over the years to develop and maintain. They are bloated and integrated with other systems in ways that sometimes only a handful of people at the bank still understand. They often still rely on batch processing. Yet, they more or less work, which makes it even more difficult to make the tough decision to migrate towards a modern, cloud-native solution.
Third party core banking solutions are dominated by a small group of vendors in the United States:
Fiserv: 38% Market Share
Jack Henry: 16%
FIS: 12% (high concentration of large banks)
Finastra: 4%
(source: AITE Group LLC, 2019)
Neobanks started during the past few years don't have legacy systems or bank branches. They are helping to support a new set of core banking startups that are built for the world of cloud-based APIs. Companies like Neocova, Finxact, Nymbus, and Temenos are enabling forward-thinking banks to leverage modern application architecture.
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A five-day workshop into the problem of nuclear harm sponsored by the 2016 O'Donnell Endowed Chair in Global Studies.
The world's first nuclear weapons test—the first light of which captured here a mere .025 seconds after detonation—in the New Mexico desert, on July 16, 1945.
A world empty of nuclear weapons eludes us. State-led progress on the road to nuclear abolition has historically been slow, in part because the politico-economic forces driving the modernisation programmes of nuclear weapons states continue unabated. What little hope there remains for achieving a nuclear-weapon-free world must therefore arise out of global civil society. For this, traditional approaches involving trust- and capacity-building initiatives would be enhanced by the alternative insights and understandings about the problem of nuclear harm that can only be derived from the humanities, and in particular environmental philosophy, dialogue, ethics, and the creative arts.
This O'Donnell Visiting Educators Program in the Nuclear Humanities—to be held September 24-28, 2016—enables participants to explore several such alternative pathways to nuclear disarmament, and to consider the possibility of creating one of their own. Geared towards students in the liberal arts the workshops are intended to supplement existing degree programmes in politics, philosophy, history, art, literature, economics, environmental humanities, religion, physics, film and media, gender, anthropology, non-Western thought, as well as race and ethnicity.
The program will take place over five days, with participation in the half-day field trip on Day 4 encouraged, but not expected. The session on Day 3 is open to the public, and commemorates the U.N. International Day for the Total Elimination of Nuclear Weapons.
The 2016 Nuclear Humanities intensive workshop was designed and delivered by N.A.J. Taylor, on the invitation of Shampa Biswas, Chair of the Politics Department and Paul Garrett Professor of Political Science at Whitman College. It was sponsored by an O'Donnell Endowed Chair in Global Studies grant.


If you like an under powered, non--Bluetooth, single CD playing radio you're absolutely correct. If you're going to try to sell this, you need to list a price, a location (I see that you're in Wilmington, NC but you might want to put that in the post)), and a picture or two (not really necessary, everybody knows what they look like). As an idea of worth, I sent the OEM radio from my 2003 to a friend for the shipping cost.
Last edited by kgf3076; 11-11-2018 at 10:40 AM.
Original S2000 Steering to VGS Steer=Possible?
How much is original wheel for S2000?


text:
using System.Web.Http;
using Newtonsoft.Json.Serialization;
using System.Net.Http.Headers;

namespace Selly.Website
{
    public static class WebApiConfig
    {
        public static void Register(HttpConfiguration config)
        {
            config.Formatters.JsonFormatter.SerializerSettings.ContractResolver = new CamelCasePropertyNamesContractResolver();

            config.Formatters.JsonFormatter.SupportedMediaTypes.Add(new MediaTypeHeaderValue("text/html"));

            // Web API routes
            config.MapHttpAttributeRoutes();

            config.Routes.MapHttpRoute(
                name: "DefaultApi",
                routeTemplate: "api/{controller}/{action}/{id}",
                defaults: new { id = RouteParameter.Optional }
            );
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Proofreading inspection provides an extended spell and grammar checking.

You can change inspection settings in Preferences.


text:
intelNews.org
Expert news and commentary on intelligence, espionage, spies and spying
About intelNews
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Make a Media Inquiry
A specialized intelligence website written by experts, since 2008
News you may have missed #751
June 25, 2012 by Ian Allen Leave a comment
By IAN ALLEN | intelNews.org |
►►Ex-CIA officer remembers his KGB rival. In April, Leonid Shebarshin, a retired General of the KGB, who was often referred to as "the last Soviet spy", was found dead in his downtown Moscow apartment. Apparently, he had committed suicide. Now Milt Bearden, who was the CIA's Chief of the Soviet/East European Division during the final years of the USSR, has written a piece in which he remembers Shebarshin. He says that, even though Shebarshin was "the closest thing [he] had to a main adversary" in the USSR, the two became friends in the late 1990s, despite the fact that Shebarshin remained a true believer in the USSR until the very end of his life.
►►NSA won't reveal how many Americans it spied on. Last month, US Senators Ron Wyden and Mark Udall –both members of the US Senate's Select Committee on Intelligence– asked the NSA how many persons inside the US it had spied upon since 2008. But Charles McCullough, the Inspector General of the Office of the Director of National Intelligence, has told the two Senators that giving such a figure of how many Americans were spied on was "beyond the capacity" of NSA's oversight mechanisms, and that –ironically– looking into this matter would violate the privacy of American citizens.
►►Russian scientist who 'spied for China' freed. Igor Reshetin, the former director of Russian rocket technology firm TsNIIMASH-Export, who was jailed in 2007 for selling state secrets to China, has been released on parole. Reshetin had been initially sentenced to nearly 12 years, for illegally selling state-controlled technology secrets to a Chinese firm, and with stealing 30 million rubles (US$925,000) through a scheme involving bogus companies. His initial sentence was later reduced on appeal.
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Many customers are searching for "Www Loanpickup" A payday advance loan is one that you can obtain from a company that is willing to give you what is called an unsecured loan. This simply means that, unlike a traditional loan from a bank, you do not have to have any form of collateral. What they are looking for are people that have gainful employment, and preferably that have above average credit. However, in most cases, they are not going to be concerned about your credit score at all. You can get promo code at Www Loanpickup.
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For all of you inquiring minds, especially children.
I frequently receive inquiries by e-mail regarding Swans, the birds. Most often, the queries come from pupils. They ask questions about the name of a mother Swan, the baby Swan, a group of Swans, and they invariably ask for pictures.
Anyway, in the spirit of the holidays and in the hope that I can answer all these questions for good (so that I need not repeat myself time and again), here it goes, with my very best wishes to all.
The mother of a swan (female) is called a pen.
The father of a swan (male) is called a cob.
Young swans are called cygnets.
A swan's beak is called a bill. Please check http://www.taiga.net/swans/head_and_bill.html to learn about the different bills swans have.
A group of swans is generally and generically called a flock of swans; but, according to the Oxford English Dictionary, the correct appellation is a wedge of Swans (when they are flying in a "V" formation). I've also heard of a bevy of Swans but I am not certain this is correct. A bevy usually refers to a group of larks or quails. So, I am afraid that I can't bring a definite answer on this one. Here, on the Swans Commentary Web site, we refer to the flock; that is, the collective of writers and essayists who generously contribute their work on a bi-weekly basis. Anyway, for those of you who wish to learn more about Group Names of Birds, please visit http://baltimorebirdclub.org/gnlist.html; and you can also check out James Lipton's An Exaltation of Larks from your Public Library. Lipton describes in great details these collective nouns that have embellished the English language for centuries.
I am sorry if I cannot provide you with pictures of swans. Our site is not geared toward this function. We do have one though, and I am more than happy to show it to you.
You may want to learn more about these gorgeous birds and see myriad pictures (always ask permission if you want to use the material displayed on the respective sites). So I have compiled a few links that you should feel free, and hopefully eager, to peruse and explore.
And of course, when you want to read out-of-the-box ideas, when you are ready to dream and invent the future, we will be honored to have you visit us at Swans Commentary!


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Soldiers for Sale – How Pakistan and Turkey are leading the medieval mercenary culture in the 21st Century
A handout picture taken and released by the Turkish Presidential Press Office, shows Turkish President Recep Tayyip Erdogan (L) welcoming Pakistan's Prime Minister Imran Khan (R) ahead of their meeting at the Presidential Complex in Ankara, on January 4, 2019. (Photo by KAYHAN OZER / AFP) / RESTRICTED TO EDITORIAL USE - MANDATORY CREDIT "AFP PHOTO / TURKISH PRESIDENTIAL PRESS OFFICE/ KAYHAN OZER" - NO MARKETING NO ADVERTISING CAMPAIGNS - DISTRIBUTED AS A SERVICE TO CLIENTS
The Middle East and its surrounding region have witnessed several conflicts over the past year, including the ongoing Nagorno-Karabakh conflict in South Caucasus, the Yemen Civil War, the Syrian Civil War and the Libyan war. Such wars, many of them ignited by Turkey's Islamist President Recep Tayyip Erdoğan, have changed the rules of engagement. These wars have reinvigorated the medieval mercenary culture of putting soldiers on sale at an industrial level. Countries like Pakistan and Turkey have been putting soldiers and jihadists on sale in expeditionary wars far away from their country.
While Turkey is employing the low-cost Syrian Jihadists, Islamabad has gone as far as putting its own Army on sale, in face of the ongoing economic crisis in Pakistan. Libya, Kurdish areas, or Idlib in Syria, Nagorno-Karabakh and Yemen, every single theatre of conflict has been dominated by proxies and mercenaries coming from the two Islamist nations.
The use of Syrian Jihadists first came into the picture last year, when Erdoğan decided to launch an offensive into Kurdish-held Northeastern Syria. Turkey used Syrian Jihadists alongside its troops to commit some of the most horrifying human rights violations against Kurdish fighters, who have been instrumental in fighting the Islamic State (ISIS).
It seems that Ankara was so engrossed by the successes of low-cost warfare through Syrian Jihadists that it decided to deploy them in all the wars that Turkey has waged. Therefore, in Libya too, Turkey is using hardened Syrian militants to support the Muslim Brotherhood regime against Haftar's LNA forces despite a UN arms embargo on Libya.
And now Turkey is using the same tactic in the Nagorno-Karabakh region where Azerbaijan and Armenia are currently engaged in hostilities. Azerbaijan is a Turkish ally, and Ankara has openly supported the Azerbaijani offensive against Armenia. But Turkey is, of course, not using its own military troops to back Azerbaijan. It is using the low-cost Syrian Jihadist proxies to back Azerbaijan on Turkey's behalf.
According to ORF, the Syrian fighters pressed into service in Nagorno-Karabakh aren't hardened militants unlike those deployed in Libya. Many of the Syrian fighters engaged in Nagorno-Karabakh belong to normal families and don't have any prior terror links as such. But this is where medieval mercenary economics kicks in. For these jobless Syrian fighters, the prospect of fighting for Turkey in a third country is too lucrative to reject. And therefore, they are fighting on Ankara's behalf.
As for Ankara, deploying Syrian fighters is always a better option, no matter how detestable and inhumane it may be. Firstly, Turkey suffers fewer military casualties by sending in Jihadist mercenaries. And secondly, Ankara doesn't have to spend as heavily on Syrian mercenaries as it would have to spend on regulars if they were sent to war. Therefore, proxy wars boost Turkey's bandwidth to wage new, Islamist wars.
Anyhow, even if Syrian fighters are being lured on account of their socio-economic conditions, their entry into conflict theatres can be devastating. And now even Nagorno-Karabakh is facing a likely threat of becoming a terror zone. Turkey's proxy wars are expanding Jihadist terrorism across the Middle East and beyond.
On the other hand, Pakistan, which looks upon Turkey as its godfather has gone a step further. Pakistan doesn't have foreign mercenaries to use on third countries' land. So, it has come up with a unique solution and has started putting its own Army troops on sale.
Last year, it was reported that Pakistani ex-Army mercenaries were involved in the Yemen War to fight on Saudi Arabia's side against the Iran-backed Houthi rebels. The Pakistani mercenaries were led by none other than former Army Chief General Raheel Sharif. Pakistan's objectives though were somewhat different from Turkish expansionism in the Middle East. Islamabad has been battling an endless economic crisis and, therefore, Pakistan decided to put its so-called security establishment on sale as a quid pro quo for Arab financial help.
This year again, Pakistan is believed to have sent its troops to fight alongside the Turkish military and Azerbaijan Army in Agdam, a town located in the disputed Nagorno-Karabakh region. Moreover, Pakistan's armed forces have officially stated that they support Azerbaijan's offensive against Armenia. Going ahead, Islamabad might actually send in troops for Azerbaijan's help to please Ankara.
Pakistan and Turkey are thus leading the brutal, medieval mercenary culture at the expense of peace and security in several conflict zones in and around the Middle East.
Categories: Analysis
Tags: Pakistanturkey
"Khalifa" Erdoğan officially declares Turkey a "one-party dictatorship"
by Abhinav Singh 15 January 2022
by Tanya Trivedi 14 January 2022
by Abhishek Kumar Singh 13 January 2022
Rajeev Chandrashekar destroys Imran Khan's dilemma
Pathankot Attack was an ISI operation conducted by Sikh extremists
by Akshay Narang 11 January 2022


text:
PureTech hails new avenue for Alzheimer's disease treatment
By Jane Byrne contact
29-Apr-2021 - Last updated on 29-Apr-2021 at 12:40 GMT
© GettyImages/Urupong
Related tags: Alzheimer's disease, antibodies, AAV platform
Preclinical research, published in Nature, suggests a new avenue for Alzheimer's disease (AD) treatment, through restoring lymphatic flow in the brain
AD is the most prevalent cause of dementia and, currently, there is no effective treatment.
Led by Dr Jonathan Kipnis, professor of pathology and immunology at Washington University School of Medicine, working with PureTech scientists, the study suggests that enhancing meningeal lymphatic drainage could improve clinical outcomes in AD, either alone or in combination with passive immunotherapies, such as antibodies directed at amyloid beta (Aβ).
Meningeal lymphatic drainage has an important role in the accumulation of Aβ in the brain, according to the team, and the study indicates that clinical outcomes of AD could be improved by restoring healthy drainage patterns.
The new paper builds on foundational research published in Nature in 2018, in which Dr Kipnis's lab showed that disrupting meningeal lymphatic drainage promoted Aβ accumulation in preclinical models of Alzheimer's disease.
The more recent work finds that improving meningeal lymphatic drainage enhances Aβ clearance in conjunction with passive immunotherapies and modulates microglia activation to improve neural tissue homeostasis in aged transgenic Alzheimer's disease mice.
PureTech holds an exclusive license to the underlying intellectual property. The company said it is aiming to advance this work via its wholly-owned meningeal lymphatics research program, which is targeting a range of neurodegenerative and neuroinflammatory diseases.
Halting AD progression
We asked Joe Bolen, PhD, chief scientific officer at PureTech, to spell out more clearly the meaning of "improved clinical outcomes" of AD seen in the study.
"Improved clinical outcomes of AD means decreasing the rate of progression of the disease through the development of more effective therapies that diminish damage to the CNS. The research summarized in the article suggest that the functional state of the meningeal lymphatics impacts the brain vascular system as well as the degree of CNS neuroinflammation mediated by brain microglia in addition to providing a means to drain potentially harmful macromolecules such as amyloid beta and phospho-tau."
In the therapeutic experiments summarized in the article, VEGF-C was utilized to help improve lymphatic vascular function and was combined with one of two different monoclonal antibodies recognizing different forms of amyloid beta in order to yield the most efficient amyloid beta removal, said Bolen.
"In those experiments, VEGF-C was produced through recombinant Adeno-associated virus (AAV) infection of meningeal cells," he added.
Avoiding virus mediated molecule delivery
In terms of whether there are any limitations or inherent risks involved in this avenue of treating AD though, he said that such an approach for VEGF-C, or any other biologic intended for meningeal lymphatics, would be challenging for patients as immune responses to the AAV would preclude multiple courses of therapy that would likely be required.
"Our current plans do not anticipate requiring virus-mediated delivery of VEGF-C or any other biomolecule in order to effectively rescue dysfunctional meningeal lymphatics," he told BioPharma-Reporter.
Reviewing the progress that PureTech's meningeal lymphatics research program has made to date, he said the team had prioritized several promising potential therapeutic approaches to modulating meningeal lymphatic drainage.
"Our wholly-owned meningeal lymphatics program in collaboration with the Kipnis lab along with several other prominent academic research labs have made significant strides in our understanding of the functional and anatomical magnitude of the meningeal lymphatic network, its vascular adjacencies and the interplay between these networks with the resident and transitory meningeal immune system."
Related topics: Clinical Development, Clinical evolution, Patient centricity, Phase III-IV, Phase I-II
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By PRA Health SciencesChallenges Arise as the Need for Pediatric Research Increases


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PROFESSOR OF UNIEVANGÉLICA IS APPROVED FOR PHD IN ITALY
Professor Gino Bertollucci Colheirinhas of the Mechanical Engineering course will carry out a year of his PhD studies at the Università di Roma La Sapienza in Rome in Italy as of August of this year. Gino is currently a doctorate student in Mechanical Sciences from the University of Brasília and will receive a scholarship from CAPES, a federal government agency.
The teacher will be work alongside professors Franco Bontempi and Francesco Petrini at La Sapienza, one of the best in the world in the area of technology and will continue his studies in control of vibrations in wind turbines.
Gino said that the idea came after meeting Professor Bontempi at a congress and receiving an invitation to work together. "I decided to formalize this bond by asking for help for CAPES and participating in the selection process", he said.
The teacher sees that this opportunity can contribute to knowledge and the growth of UniEVANGÉLICA. "It is not only the specific gain related to the research, there is a great gain in the link with other scientists who are reference in the area, we can maintain this contact between UnB, La Sapienza and UniEVANGÉLICA", stressed the professor.
Alunas da Enfermagem apresentam TCC em inglês
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UniEVANGÉLICA received the visit from representatives of Radford University, Virginia, in the United States. Professors Dr. J. Stephen Childers from…
RESEARCH DEPARTMENT OF THE LAW SCHOOL DOES UNPRECEDENTED WORK
The Research Department of UniEVANGÉLICA's Law School (NPDU) has been doing a work for the last four months that has…
UNIEVANGÉLICA RECEIVES LECTURE ABOUT ERASMUS + CAPACITY BUILDING PROGRAM
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Mortar Rounds are bundles. Picking them up gives credit towards Aid Centurion Truthbringer in Echoslab Arches, as does giving them to nearby Iron Legion Engineers.
Throw 1 0 Throw the mortar shell.
These shells are fairly weak, particularly compared to Unexploded Mortar Shells.
Can be safely dropped and picked up again. Using the bundle destroys it.
This page was last edited on 17 September 2017, at 18:09.


Contact us - Got a question, let us know.
When a helping hand is all you need.
Mock Transfer Tests use a number of venues in the Bushey area. Joining instructions will be provided for each event to advise which venue the event is being held.
Please see this link for How to find us.


InnoPocket has announced the release of two new handheld cases and a Sony stylus. The Metal Deluxe Case for Palm Tungsten T handheld and the Metal Deluxe Case for Sony NX60 and NX70V. Both are made of 100% anodized aircraft grade aluminum and form to the devices profiles.
If there is something that I don't like on Palm HardCase is that it's unpracticable to open the palm. And, NewPen isn't as good as old hard graffiti area.
I don't know about the Palm hardcase, but it doesn't seem like something I'd want. I took a look at it in CompUSA, and I agree with your assesment.
Also, I pre-ordered the Palm Scuba Sleeve, but once I received it, I regretted it. The design is counter intuitive and just adds extra bulk. Now all it does is collects dust on my desk.
I really miss the extra slot on the left side of the Palm V/m5xx series. The simple slide-in leather cover is far and away better than the provided plastic which came with the Tungsten, or any other case to date, for that matter.
However, this new Innopocket case looks interesting and something I may want, but I'll wait for reviews to come out first.
I sure wouldn't want a case that has that many cutouts. I find it uneccessary to have one for the SD slot and all. The only one I can see that would be useful is a cutout for the headphone jack.
I also dislike cutouts. One of the reasons I bought a Rhinoskin Aluminum hard case was to protect my m505 (at least a little) from moisture damage - once I visited Niagara Falls and all my clothing was soaked. I'm lucky my unprotected Palm survived intact in my pocket.
If you ever get caught in a thunderstorm without a raincoat or umbrella with a Palm in your pocket, you'll know what I mean.
Yes, I am aware that there are completely waterproof cases out there, but they're too bulky and impractical for my daily use.
"I find it uneccessary to have one for the SD slot"
How else do you think the slider is going to work?!
They could have easily made the top of the cover connected to the front continue all the way over the top of the unit instead of just forming a small lip over the top. This would make the case much more appealing to me. Then you could open it up and still open the slider, which for those of us with Tungstens, rarely ever happens. There is enough software out there to prevent you from having to open the slider at all. In addition to not needing an opening for the SD card, I don't think there are many people who beam, or receive while their case is closed.
Say, why not make a replacement cover to take the place of the plastic cover. Which I lost for a while. Or make them in colors. Possibly they can just make a new cover plate to replace the clear one that ships with the new Palm!
Yes. I would like a clear plastic cover, but that it could open to the back (like the Parallel Design or the old Palm III). I would also like it to have cutouts for the hardware buttons, this way I could read AvantGo or a book and browse, without opening the cover.
Is it just me or is that a left handed case? I personally would like to see a flip case for the Tungsten T. Kind like Kenningston made for the M50X Palms.


There is an ethical ponderable at the heart of Tim Crouch's England, a site-specific two-hander that challenges its audience to contemplate the value of art itself, and it proves to be entirely at the expense of the audience.
The action takes place in some kind of art gallery. The details vary depending on where the production takes place. In Dublin, it took place at the Dublin City Art Gallery, also known as The Hugh Lane Gallery. As such when the actors appear (Crouch himself and Hannah Ringham), they provide a brief history of the venue and seem to honour its history. As the play progresses, the audience is taken through a number of rooms in the gallery and introduced briefly to some of the art.
But this is all a feint. After a duologue in which the two actors recite what seems an internal monologue by a single character about their wealthy, art-loving boyfriend and their own ill health, the play deals its trump card. All of the ruminations about the nature of art, all the history and culture of the venue you are standing in, all of the pretentions of the theatre-goer are directly attacked by an ethical drama regarding how the character's health difficulties have been resolved at the cost of the life of another person. If you want the detail – the unwell lover of the art-dealing millionaire gets a heart transplant from a middle-eastern youth whose death may or may not have been entirely necessary.
It's a strong metaphor, yes. It's a provocative move (literalised by a move in the venue and performance space from having the audience stand as if being guided through the venue to sitting in seats as if observing an ordinary play), yes – give us art, real art, then show us how valueless it really is. But it's also painfully self-aware and self-involved, fairly boring for the most part, and woefully overextended even at just over an hour. The only justification for the use of the space – the much vaunted site-specivity – is to poke a finger in the eye of (western, imperial) culture itself. While this might not be such an issue if you are not adverse to a bit of eye-poking, the deeper problem is that as a play, the use of the venue serves no other function whatsoever.
As a play, Crouch's text is as effectively heard as seen delivered. His staccato poetry, rhyming and chiming voices interrupting, repeating, intermingling to create a stream of consciousness (later contrasted when the voices finally represent two characters, one of whom is translating for another that is not 'heard') is really ideally suited to radio. It is really an aural work, and its repeated mantra "look" and frequent exhortations to envision places and spaces beyond the venue space itself deliberately, ironically, nullify the value of venue in which you experience the play.
Again, bravo in terms of aesthetic concept perhaps, but apart from the initial (gestural) honorifics to the venue and the artists housed there, there is no compelling need whatsoever to see Crouch and Ringham perform in any space, let alone a specific space, from either a dramatic or a textual point of view. As if acknowledging this in some way, their performances are mostly carried out in a kind of ecstatic daze, as if they've just taken pills or found a religion which make them incapable of any kind of expression other than joy. Though this is supposed to lend weight to the final scenes where more desperation creeps in, it doesn't. Again, the voices are doing the work through Crouch's written word, and there's no reason at all to be in a shared physical space with these performers beyond pure metatheatrical rhetoric.
How much patience you will have for this deliberate mischievousness will perhaps depend on your predisposition to Crouch's work, the endurance of your feet, and how hilariously ironic you find the use of the chosen art gallery or other venue. The play has already been a significant success and won awards, and it is due to tour through 2009. But the point, though compelling, is made quickly once finally made and the journey to get there is not as interesting as it sounds.


text:
School of the Humanities and Social Sciences
McDonald Institute Monographs & Conversations
[17] Gardening time: Monuments and landscape from Sardinia, Scotland and Central Europe in the very long Iron Age
morentur in Domino libere et in pace: cultural identity and the remembered past in the medieval Outer Hebrides
Gardening_Time_Chapter20.pdf (PDF, 3Mb)
Raven, John
MacLeod Rivett, Mary
Stoddart, Simon
Aines, Ethan D.
Malone, Caroline
Raven, J., & MacLeod Rivett, M. (2021). morentur in Domino libere et in pace: cultural identity and the remembered past in the medieval Outer Hebrides. In Stoddart, Simon. McDonald Institute for Archaeological Research, Gardening time: Monuments and landscape from Sardinia, Scotland and Central Europe in the very long Iron Age. [Book chapter]. https://doi.org/10.17863/CAM.81519
Gardening may seem worlds away from Nuraghi and brochs, but tending a garden is a long process involving patience, accretion and memory. Scholars argue that memories are also cultured, developed and regained. The monuments in Scotland and Sardinia are testament to the importance of memory and its role in maintaining social relations. This collection of twenty-one papers addresses the theme of memory anchored to the enduring presence of monuments, mainly from Scotland and Sardinia, but also from Central Europe and the Balkans.
This book, and the conference upon which it was based, were funded by The ACE Foundation, The Fondazione Banco di Sardegna and the McDonald Institute. We are grateful to the British School at Rome and Magdalene College, Cambridge for their support.
This record's DOI: https://doi.org/10.17863/CAM.81519
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)


A celebration of the life and ideas of Charles Darwin, this project explored the richness and diversity of evolution through the creation of a series of sculptures inspired by creatures from Earth's distant past. Youth groups and members of the public were given the opportunity to work with the artist at an open worksite in Shrewsbury's Quarry Park.
Two local secondary schools were also closely involved.
Students learned the techniques of wood sculpture and developed their own designs for beings that might never have existed – or whose time is yet to come. The culmination of the project was the installation of the sculptures in the Shrewsbury's Dingle Gardens where they remained on display for over two months. The project was part of Shrewsbury's Shift Time Festival. It was funded by Shrewsbury and Atcham Borough Council and Awards for All.


text:
by Stephen Orr
Westward Ho! is part drama, part vaudeville, part Orpheus in the Underworld. This play for voices begins with a fifty-something ex-greyhound trainer, George Lake, recovering in hospital from an un-named condition. A twelve-year-old boy, Carl Levin, arrives and tells George to get dressed, as a 'man' has asked to see him. After some argument, George agrees to go. The pair follows a map the man has given the boy. They walk, dance and sing their way through Adelaide, passing the homes, workplaces, pubs and alleyways George has spent his life around.
Only at the end of the pair's journey do we find out who the 'man' is, what he wants from George, and why the boy was sent to fetch him.
The play uses stories, stray characters, and scraps of life to build up a picture of Adelaide. Not the politics, the history, the Establishment, but the lies, secrets, and myths.
Westward Ho! owes its conception and execution to comedians like Roy Rene, singers like George Formby, and poets of place like Dylan Thomas and James Joyce. The play is a flummery of lost loves, disappointments and small salvations. At its core is the relationship between a man who's never fully valued those around him, and a boy who teaches him, before it's too late, what he's been missing.
Form/Style: radio play/play for voices
Themes: history
WESTWARD HO! SCRIPT quantity
WESTWARD HO! SCRIPT $15.00
WESTWARD HO! COPY LICENSE quantity
WESTWARD HO! COPY LICENSE $5.40
THE HALL COMMITTEE


text:
Tag: Long Chim
David Thompson has made Long Chim's top quality Sriracha Sauce available for retail
Aaharn Sriracha Sauce is, according to renowned Long Chim chef David Thompson, arguably the world's best tasting sriracha sauce to exist. And who are we to argue? Thompson uses to sauce in his restaurants worldwide, and with the kind of acclaim that regularly surrounds the chef and pretty much everything he does, it's safe to say that his endorsement of this product is a kind of gold standard.... Read More | Share it now!
Time Out Sydney Food Awards 2017 winners announced
September 28, 2017 / Chris Singh
For the ninth year in a row, the 2017 Time Out Sydney Food Awards have went through and scanned just about every restaurant, bar, diner and eatery that has made a dent on the city's dining scene this year, and picked out the top performers. From fine to casual dining, cheap eats to cafés, the recently held ceremony at Porteño on Cleveland saw quite a few legends and future legends being celebrated for their dominance over the scene.... Read More | Share it now!
David Thompson to open Long Chim in Martin Place (Sydney)
May 4, 2016 / Chris Singh
Mid-way throughout August this year Sydney will be getting a brand new Thai street food restaurant from world-renowned Chef and restaurateur David Thompson, a man who has long been considered as an authority on Thai food. Thompson has confirmed that he'll be bringing his famed Long Chim restaurant in Sydney, adding it to his list of successful ventures in Perth and Singapore under the same brand. ... Read More | Share it now!


text:
Princesses, Slaves, and Explosives: The Scandalous Origin of Vaccines
Kiona Smith-Strickland
The history of inoculation may sound a little dry, but it's really an epic tale of human trafficking, semi-illicit experimentation, and high explosives. It's a globe-hopping story that stars harem girls, noblewomen, prisoners, princesses, slaves, and even a witch hunter.
In the Shadow of Smallpox
Smallpox has troubled humanity for thousands of years. Wherever we've settled in the world, the smallpox virus has eventually followed.
A dangerously high fever comes first, accompanied by headaches, back pain, and vomiting. Painful sores open in your mouth and nose, and a rash spreads all over your body. Blisters form and fill with pus; these pustules eventually scab over and dry up. About 30% of people who catch smallpox will die; the rest will live with scars left behind by the pustules.
People eventually noticed one very important thing about smallpox: those who had survived didn't catch the disease again, or if they did, they didn't get very sick the second time around.
History doesn't record who first got the idea to expose healthy people to pus from infected patients' pustules - or how they talked anyone into letting them try it. But the practice seems to have sprung up independently in several places: India, China, West Africa, and elsewhere. The idea was already an old one in 570 AD when people in Europe started calling it "variolation," from the Latin name for smallpox, Variola. (Later generations used "variolation" and "inoculation" interchangeably; today "inoculation" also includes vaccination.)
Variolation usually meant rubbing pus from a smallpox pustule - a good ripe one, the runnier, the better - into a cut or scratch on a healthy person's arm, but in China, people just soaked a cotton ball in infected pus and stuck it up their noses. (Ah, the good old days, right?)
Most modern experts would consider this "stick it up your nose" strategy as the exact opposite of what you're supposed to do with a deadly pathogen. But it was the best option available at the time, and it worked remarkably well. Only about two percent of people who were exposed to smallpox through inoculation died of the disease, and only two to three percent spread the infection to others. Today, that wouldn't be an acceptable safety record for a vaccine, but in the 17th and 18th centuries, it beat the daylights out of a 15-30% chance of dying if you caught smallpox on your own.
Herd Immunity and the Harem
Circassia in 1700. Image: Adamsa123 via Wikimedia Commons
In the northern Caucasus Mountains, women of the Circassian ethnic group traditionally inoculated their children at about six months, and many Circassian women carried their knowledge with them when they were trafficked to Turkey as slaves - a common fate for many Circassians up until the early 20th century.
The French philosopher Voltaire described the situation in 1778:
"The Circassians are poor, and their daughters are beautiful, and indeed, it is in them they chiefly trade. They furnish with beauties the seraglios of the Turkish Sultan, of the Persian Sophy, and of all those who are wealthy enough to purchase and maintain such precious merchandise."
The unfortunate Circassian women who ended up in the Ottoman Sultan's harem left their mark on Turkish culture, one that would eventually spread across Europe and into North America. According to Voltaire,
"The Turks, who are people of good sense, soon adopted this custom, insomuch that at this time there is not a bassa in Constantinople but communicates the small-pox to his children of both sexes immediately upon their being weaned."
According to some sources, inoculation first caught on in Turkey in the late 1600s, thanks to the Sultan's trafficked Circassian women. Fifty years later, another woman carried the technique to England and eventually helped spread it throughout Europe.
A Woman on a Mission
Lady Mary Wortley Montagu in Turkish attire, painted 1756. Image: Wikimedia Commons
In December of 1715, Lady Mary Wortley Montagu was on top of the world, or at least her rather luxurious corner of it. She was the daughter of an English Duke and the wife of a member of Parliament (with whom she'd eloped a couple of years earlier to avoid marrying the unfortunately named Clotworthy Skeffington). Her wit and beauty made her the toast of King George I's court.
Then she caught smallpox.
She recovered, but with the characteristic pockmarked scars. Early in 1716, she left London behind to accompany her husband to Turkey, where he was the King's new ambassador to the Ottoman court. In early 1718, she wrote to a friend,
"The small-pox, so fatal, and so general amongst us, is here entirely harmless, by the invention of ingrafting, which is the term they give it. There is a set of old women, who make it their business to perform the operation, every autumn, in the month of September, when the great heat is abated. People send to one another to know if any of their family has a mind to have the small-pox: they make parties for this purpose, and when they are met (commonly fifteen or sixteen together) the old woman comes with a nutshell full of the matter of the best sort of small-pox, and asks what vein you please to have opened. She immediately rips open that you offer to her, with a large needle, (which gives you no more pain than a common scratch) and puts into the vein as much matter as can ly upon the head of her needle, and after that, binds up the little wound with a hollow bit of shell; and in this manner opens four or five veins."
Soon after, she convinced embassy surgeon Charles Maitland to variolate her five-year-old son, Edward. The procedure went well, and Mary Wortley Montagu was now a woman on a mission:
"I am patriot enough to take pains to bring this useful invention into fashion in England; and I should not fail to write to some of our doctors very particularly about it, if I knew any one of them that I thought had virtue enough to destroy such a considerable branch of their revenue, for the good of mankind. But that distemper is too beneficial to them, not to expose to all their resentment the hardy wight that should undertake to put an end to it. Perhaps, if I live to return, I may, however, have courage to war with them."
Cotton Mather and the Anti-Vaxxers
The first slaves arriving in Boston in 1683. Image: Library of Congress.
While Lady Montagu learned about inoculation, the practice was also beginning to spread to North America. In Massachusetts, an aging Puritan minister named Cotton Mather (now best known as the architect of the Salem Witch Trials, which killed 24 people in 1692, mostly women), had a chat about smallpox with an African man named Onesimus, a slave in his Boston household.
"He told me that he had undergone the operation which had given something of the smallpox and would forever preserve him from it," Mather wrote in a July 1716 letter to physician John Woodward. Onesimus described the inoculation process and showed off the small scar it had left on his arm.
"How does it come to pass, that no more is done to bring this operation, into experiment and fashion in England?" Mather asked Woodward. He was fascinated by the lifesaving potential of inoculation - but he didn't appreciate the knowledge quite enough to free the man who shared it with him. (Mather did free Onesimus a few months later, but only after making him promise to pay five pounds and to do chores for the family whenever they asked. Nobody ever said Cotton Mather was a nice guy.)
But when a ship from the West Indies sailed into Boston with infected sailors on board in April of 1721, Mather remembered what Onesimus had shared. As a well-known minister in 18th century Massachusetts, Mather had both celebrity and political clout, and he used both to advocate for inoculation. He addressed Boston's physicians on June 6, 1721, making an earnest case for inoculation as the best way to stop the disease from spreading.
That address stirred up an immediate controversy among Boston doctors and even in Mather's own congregation. People worried that inoculation would be too dangerous and that it would only spread the disease more quickly. Others argued that it was a "heathen practice" and in defiance of the Puritan view of disease as part of God's plan for whoever might fall ill.
He managed to convince only one man: a doctor named Zabdiel Boylston (fact: names were at least 48% cooler in the 1700s, with some very obvious exceptions). Boylston launched a variolation campaign, and he sought input on variolation from African slaves around Boston who had experience with the process, though their contributions, like Onesimus', went mostly unrewarded and remain anonymous to this day.
Things Get Violent
Cotton Mather, about 1700.
Throughout the summer of 1721, Mather published tracts and treatises, gave addresses and sermons, and wrote letters arguing that inoculation was safe, moral, and urgently necessary. But Boston was having none of it. Although people had embraced Mather's every word when he was calling for the hanging of women in Salem for putting curses on their neighbors, they recoiled at the idea of inoculation. It was a weird time.
In July, he wrote in his diary:
"The Destroyer, being enraged at the proposal of any Thing, that may rescue the lives of our poor People from him, has taken a strange Possession of the People on this Occasion. They rave, they rail, they blaspheme; they talk not only like Ideots but also like Franticks, And not only the Physician who began the Experiment, but I also am an Object of their Fury; their furious Obloquies and Invectives."
All the while, the infection raged. At its peak, some sources estimate that half of Boston was sick. Boylston inoculated as many people as he could convince, but that wasn't nearly enough of the population to have any real chance of stopping the spread of the infection. As the epidemic worsened, people blamed Mather and Boylston for its swift, unstoppable spread.
"Towards three a clock in the night, as it grew towards Morning of this Day, some unknown Hands, threw a fired Granado into the Chamber where my kinsman lay, which uses to be my Lodging-Room," he wrote in his diary on November 14 after a rather eventful night. A relative had traveled to Boston for inoculation and was staying with Mather while he recovered. He almost didn't make it home.
But Mather and his family were lucky. The firebomb - a heavy iron ball, split into two halves filled with gunpowder and turpentine, according to Mather - hit part of the window casement on the way in and bounced to the floor in a way that just happened to put out the fuse in the process. Because the bomb failed, Mather got to read the message, tied to the fuse with string: "COTTON MATHER, You Dog, Dam you; I'll inoculate you with this, with a Pox to you."
To make his case for variolation, Mather published data on the fatality rate for inoculation - about 2% - and for actual smallpox infection - about 14% in the Boston outbreak. It was the first documented use of comparative data in medicine, and it eventually helped persuade people to accept inoculation.
Meanwhile, Back in England
Lady Mary Wortley Montagu.
That same year, Lady Montagu insisted that Charles Maitland inoculate her four-year-old daughter in a demonstration for the royal physicians. It worked, and in August, the King gave Maitland permission to conduct a trial of the technique on prisoners in London's Newgate Prison. Six men volunteered on the promise of the King's pardon for the survivors.
When all six prisoners survived and later proved to be immune to smallpox, Maitland moved on to testing his inoculation on orphaned children, who were slightly less expendable than convicted criminals. But only slightly.
The plucky orphans also survived, so Maitland moved on to inoculating princesses (skipping several rungs on the expendability ladder). In April of 1722, he inoculated the daughters of the Princess of Wales. After that, inoculation started to catch on in England, though it took another few decades to become widely accepted in the rest of Europe. According to Voltaire in 1774,
"It is inadvertently affirmed in the Christian countries of Europe that the English are fools and madmen. Fools, because they give their children the small-pox to prevent their catching it; and madmen, because they wantonly communicate a certain and dreadful distemper to their children, merely to prevent an uncertain evil. The English, on the other side, call the rest of the Europeans cowardly and unnatural. Cowardly, because they are afraid of putting their children to a little pain; unnatural, because they expose them to die one time or other of the small-pox."
Variolation had actually been banned in France for five years, from 1762 to 1767, after it caught the blame for an outbreak. But in 1774, when King Louis XV died of the disease after two weeks of illness, along with 10 other members of his court, his son - the newly crowned King Louis XVI — boldly decided to have himself and his two younger brothers variolated (the guillotine, rather than smallpox, finished off Louis XVI).
And eventually, inoculation did catch on in Europe, partly thanks to the data published by Mather and others, and partly thanks to Lady Montagu's trendsetting advocacy in England. It was the best defense against smallpox until 1840, when England banned variolation in favor of a new preventative: vaccination.
How Vaccination Went Viral
A milkmaid and cows, sometime between 1790 and 1843. Image: Dordrechts Museum via Wikimedia Commons.
Thirty-five years later, in 1757, a young boy named Edward Jenner received an inoculation against smallpox. Eventually, he also received most of the credit for developing the first smallpox vaccination: a way to give people immunity smallpox without exposing them to the live smallpox virus.
Cows' udders sometimes become infected with a virus that causes small pustules, similar to smallpox but less severe. The two viruses are closely related - so closely that the human immune system has trouble telling them apart. So exposure to one will help you develop immunity against the other. In the 1700s, most people in Gloucestershire and the surrounding counties knew, or at least suspected, that exposure to cowpox kept milkmaids from catching its deadlier cousin, smallpox - just as people all around the world knew that variolation worked for years before Montagu, Maitland, Mather, and Boylston. That's how Jenner heard about the connection between cowpox and immunity to smallpox; he spent the early days of his medical career in a dairy community.
In May of 1796, he tested cowpox inoculation on the nearest available child - as one does, presumably. Eight-year-old James Phipps suffered from a mild fever and aches for about nine days, and then felt better.
So of course Jenner inoculated him with smallpox a couple of months later. Phipps didn't get sick. The cowpox had given him immunity to smallpox.
Jenner self-published his results in 1798, after rejection by the Royal Society. He called the new technique "vaccination," from the Latin word vaccinia for cowpox. By inoculating people with cowpox, it was possible to protect them from smallpox, without actually exposing them to the deadly
Today, the word "vaccine" is a generic term for any substance that causes the body to develop immunity to a disease. Usually, vaccines are made from dead or weakened forms of the virus being vaccinated against. Modern vaccines use viruses, or antigens from viruses, grown in cultures in a laboratory - not an actual gob of someone else's infected pus. We've come a long way.
Whose Discovery Was It?
Benjamin Jesty in 1805. Source: Jesty.org via Wikimedia Commons
Today Edward Jenner is known as the father of vaccination - but he wasn't the first to inoculate with cowpox. In fact, the first person to vaccinate with cowpox wasn't even a doctor.
In 1791, a German teacher named Peter Plett inoculated three children with cowpox; like Jenner, he had learned about the connection from milkmaids (who probably deserve most of the credit in the long run). When he reported his results to professors of medicine at the nearby University of Kiel, they basically ignored him, so Plett resumed his teaching career. He got a little recognition in the early 1800s, but barely a footnote compared to the accolades Jenner eventually received.
But even Plett wasn't the first. A Dorset cattle farmer named Benjamin Jesty inoculated his wife and two sons with cowpox (and one of his wife's knitting needles) in 1794 to protect them from a nearby smallpox outbreak. That claim is carved in stone - literally. The epitaph on Jesty's tombstone calls him "an upright honest Man; particularly noted for having been the first Person (known) that introduced the Cow Pox by Inoculation, and who from his great strength of mind made the Experiment from the (Cow) on his Wife and two Sons in the Year 1774."
Ultimately, of course, it's probably the milkmaids and dairy farmers of rural Europe who deserve the credit for discovering the smallpox vaccine.
So why does Jenner get all the credit? Although the link between cowpox and smallpox immunity was pretty well known in dairy farming areas, it was still a new idea outside those areas. Jenner might not have been the first person to figure out the connection, or even to apply that knowledge to inoculation, but he did bring it to the attention of the scientific community and convince them to accept it.
In the words of Victorian statistician and scientist Francis Galton, "In science, credit goes to the man convinces the world, not the man to whom the idea first occurs."
Contact the author at k.smithstrickland@gmail.com or follow her on Twitter.
crazybokchoy
No! This is frickin' nightmare fuel right here! I feel my skin crawl just looking at this!


text:
Tim Burton Heading to 'Miss Peregrine's Home For Peculiar Children'
by Ethan Anderton
Source: Deadline
Earlier this year, it was reported that Fox had picked up the rights to adapt Ransom Riggs' novel Miss Peregrine's Home for Peculiar Children into a feature film. The story follows a 16-year-old boy named Jacob, who stumbles upon a home for children with strange powers on a remote island off the coast of Wales, and now the darker tale just might have a fitting director to take on the material. Deadline reports Tim Burton is in early talks to develop the book as a potential directing gig. In addition, the Alice in Wonderland and Sweeney Todd director would also be involved in choosing a writer to adapt the story.
Published back in June, here's the official synopsis of the book:
A mysterious island. An abandoned orphanage. And a strange collection of very curious photographs. It all waits to be discovered in Miss Peregrine's Home for Peculiar Children, an unforgettable novel that mixes fiction and photography in a thrilling reading experience. As our story opens, a horrific family tragedy sets sixteen-year-old Jacob journeying to a remote island off the coast of Wales, where he discovers the crumbling ruins of Miss Peregrine's Home for Peculiar Children. As Jacob explores its abandoned bedrooms and hallways, it becomes clear that the children who once lived here—one of whom was his own grandfather—were more than just peculiar. They may have been dangerous. They may have been quarantined on a desolate island for good reason. And somehow—impossible though it seems—they may still be alive.
Among the strange children Jacob encounters are a girl who can hold fire in her hands, another young woman whose feet never touch the ground, and twins who are able to communicate without speaking to each other. Though it's easy to make comparisons to X-Men and Charles Xavier's School for the Gifted, this sounds more like an Island of Misfit Toys approach to the story, and that's something Burton could bring to life rather well. Though it's yet another adaptation for the filmmaker who used to do original films like Beetlejuice, at least this story hasn't been adapted into a film or TV show previously. Interested?
Find more posts: Development, Movie News
I'm in but please no more let downs, ok Tim? I still haven't gotten the nasty taste that is Alice in Wonderland, Charlie and the Chocolate Factory and Planet of the Apes from my mouth. Alice lost it's whole point in its anticlimactic ending, Charlie was not endearing as Willy Wonka & the Chocolate Factory and Planet of the Apes, although a better budget, was not classic material. I mean seriously, you had Depp playing Wonka as Michael Jackson and Mark Wahlberg doing a gangsta stepping astronaut for christ's sake.
Johnny Neat on Nov 16, 2011
You need to read the book. Willy Wonka was Michael Jackson!
HipEchick on Nov 17, 2011


There's no denying Atlanta's drag bona fides. The city has spawned some of the best-known drag queens in the country, from RuPaul to Lady Bunny and a new generation too of 10 performers, documented in photographer Jerry Siegel's "Reveal" exhibition on view at Buckhead's Spalding Nix Fine Art.
The show is composed of a range of views of Siegel's subjects. There are the "glamour shot" oversized portraits of drag royalty like Brigitte Bidet and Evah Destruction so elaborately made up and outfitted they tend to make real women look like quitters.
There are also "behind the scenes" portraits of the artists' personas in process, of Evah Destruction with an elaborately made-up face but shirtless and hairy, a head not yet capped with a wig. In "Orchid — Smear," expertly applied artificial lashes, slashes of brow and pink eyeshadow are disrupted by the performer's direct gaze at the camera, smeared lipstick and short blond hair normally hidden by a wig.
But Siegel's most surreal, fascinating work in "Reveal" may be the sequential images that show, as they say, how the sausage is made. In a progressive frieze of images in his "Reveal" series, Siegel photographs drag queens as they take off their performance battle gear of wigs, makeup, padding, stockings, corsets and other accouterments to reveal what lies beneath. Stripped of his sequined coat and pearl festooned leather hat, Taylor Van Pelt looks like any of the tattooed and baseball cap-wearing denizens of East Atlanta. The "Reveal" portraits document the chrysalis that transforms into a butterfly, and back again.
The inventiveness and play involved in these personas draw you in. Stare long and hard, but it is still difficult to digest the extreme visual progression from the elfin, pale, boyish man who, as the gloves and the earrings and the lipstick coalesce, becomes the Jayne Mansfield study in pink of "Brigitte Bidet." Many of the portraits are poignant in their performers' imperfections and pulpy humanity; compelling in how their subjects reveal themselves to us.
Siegel's images are fun and flamboyant and over the top, as you might expect, but they are also tender and touched with sadness, not so much because of the people depicted here, but because of the layers of deception or masquerade or performance all of us act out on a daily basis. "Reveal" is ultimately a show about the carapace of identity, which some of us wear lightly and which for others carries a more crushing weight.
"Reveal," as you might expect of a show centered on performance, is all about layers. Layers of makeup, layers of artifice, but also far more complicated layers involving identity, masculinity, femininity and much that lies in between. If you're inclined to see this as a one-note show all about extravagant dress and maquillage and outsize characters, "Reveal" won't disappoint. Siegel's large-scale portraits are especially satisfying: from a distance, gorgeous impersonations of female beauty. But get all up in their business, and things begin to fall apart in the lines where wigs and foreheads collide, in shaving stubble and skin texture and the subtle details that give lie to the mirage before us.
But there's far more beneath the surface in "Reveal." Beyond a fascinating documentarian's peek into a subculture, "Reveal" has things to say about the divide between private and public selves and the complex ways we all present ourselves to the world.
Through Nov. 2. 10 a.m.-5 p.m. Mondays-Fridays. Spalding Nix Fine Art, The Galleries of Peachtree Hills, 425 Peachtree Hills Ave. NE, Building 5, Suite 30-A, Atlanta. 404-841-7777, spaldingnixfineart.com.
Bottom line: Beyond the documentary enticements of Jerry Siegel's photographs, these candid, brave performers in Atlanta's drag community reveal a vulnerability and connection to how we all perform in some sense for the world.


It is one thing to be busy, but another to be productive.
There are many people who believe that being an early riser is the key to being successful, but is that really true? We all wake up, some of us a little more vibrant and energetic than others, why? Many studies have found that there are truly significant differences between individuals in the way their brains function completely dependent on whether they are, or are not, an early riser or a night owl.
Being aware of the time of day that you are most productive truly taps into your ability to maximize performance at work, and in all aspects of your life.
Learn what time of day or night you are most productive and how to align your schedule to fit.
Learn how to optimize your patterns to be the most effective throughout your day.
Learn how bio-hacking can shift how your body and mind function.
Are you ready to discover when you are most productive and how to make the most of your day?


Excellent System AB was founded in 1993 and have since 1995 focused on Navision. As a specialist computer service company we offer the highest levels of technical expertise to companies and we provide system development and system integration services in Navision.
Clients are based largely in Sweden; however, we have clients in Poland, Finland, Russia and the Baltic countries.
Excellent System has developed a team structure to provide complete and comprehensive solutions that include Consultancy, Software, Communications, Implementation, Training and Ongoing Client Care provided by Support Agreements.


Recently, Glenns Valley Cub Scout Pack 139 held a cape design party. The boys created capes for the patients at Peyton Manning's Children's Hospital in hopes of making their stay more enjoyable.
This event was initiated by Alex Jellison as part of his requirements to become a black belt in taekwondo. Between Pack 139 and Pilsung ATA, 30 capes were made and donated to the hospital. For more information about ways to help the patients, visit The Hero Project: http://theheroproject18.org/.


text:
TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration
Author(s): Rosario Gulino, IOM Ricerca s.r.l., Via Penninazzo 11, 95029 Viagrande, Italy., Italy	Stefano Forte, Rosalba Parenti, Massimo Gulisano.
Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
Transactive response DNA-binding protein of 43 kDa (TDP-43) is a nuclear DNA/RNA-binding protein involved in gene transcription and mRNA processing. Recently, TDP-43 has been found in the cytoplasmic inclusions observed in amyotrophic lateral sclerosis. Substantial attention has been devoted to the toxic effects of the cytoplasmic TDP-43 aggregates, whereas the functional role of this protein remains poorly investigated. Interestingly, TDP-43 could be localized in the synapse and affect synaptic plasticity and locomotion in Drosophila. Here, we would like to understand if TDP-43 could modulate spinal cord plasticity in a mouse model of neurotoxic motoneuron depletion. Therefore, the expression levels of TDP- 43 and synaptic proteins such as synapsin-I and the α-amino-3-hydroxy-5-methyl-4- isoxazolepropionate (AMPA) receptor subunits GluR1, GluR2 and GluR4 were measured by western blotting. By using multivariate regression models, protein expression levels were correlated each other as well as with the motor performance. The results suggested that motor performance could be linked to the expression of synapsin-I, and that the latter could depend on TDP-43, which in turn could interact with AMPA receptors. In conclusion, our results suggest that TDP-43 is likely involved in the modulation of synaptic plasticity. Given the increasing interest in mouse models of TDP-43 gain or loss of function in neurodegenerative diseases, the elucidation of the role of TDP-43 in the spinal cord is mandatory. More generally, given the recently increased knowledge about spinal cord plasticity, we postulate that the stimulation of the intrinsic plastic potential of spinal cord would be a successful repairing strategy.
Keywords: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), cholera toxin-B saporin, motoneuron, mouse, spinal cord, synapsin-I, synaptic plasticity, Transactive response DNA-binding protein of 43 kDa (TDP-43).
Title:TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration
Author(s):Rosario Gulino, Stefano Forte, Rosalba Parenti and Massimo Gulisano
Affiliation:IOM Ricerca s.r.l., Via Penninazzo 11, 95029 Viagrande, Italy.
Keywords:α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), cholera toxin-B saporin, motoneuron, mouse, spinal cord, synapsin-I, synaptic plasticity, Transactive response DNA-binding protein of 43 kDa (TDP-43).
Abstract:Transactive response DNA-binding protein of 43 kDa (TDP-43) is a nuclear DNA/RNA-binding protein involved in gene transcription and mRNA processing. Recently, TDP-43 has been found in the cytoplasmic inclusions observed in amyotrophic lateral sclerosis. Substantial attention has been devoted to the toxic effects of the cytoplasmic TDP-43 aggregates, whereas the functional role of this protein remains poorly investigated. Interestingly, TDP-43 could be localized in the synapse and affect synaptic plasticity and locomotion in Drosophila. Here, we would like to understand if TDP-43 could modulate spinal cord plasticity in a mouse model of neurotoxic motoneuron depletion. Therefore, the expression levels of TDP- 43 and synaptic proteins such as synapsin-I and the α-amino-3-hydroxy-5-methyl-4- isoxazolepropionate (AMPA) receptor subunits GluR1, GluR2 and GluR4 were measured by western blotting. By using multivariate regression models, protein expression levels were correlated each other as well as with the motor performance. The results suggested that motor performance could be linked to the expression of synapsin-I, and that the latter could depend on TDP-43, which in turn could interact with AMPA receptors. In conclusion, our results suggest that TDP-43 is likely involved in the modulation of synaptic plasticity. Given the increasing interest in mouse models of TDP-43 gain or loss of function in neurodegenerative diseases, the elucidation of the role of TDP-43 in the spinal cord is mandatory. More generally, given the recently increased knowledge about spinal cord plasticity, we postulate that the stimulation of the intrinsic plastic potential of spinal cord would be a successful repairing strategy.
Rosario Gulino, Stefano Forte, Rosalba Parenti and Massimo Gulisano, "TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration", CNS & Neurological Disorders - Drug Targets (2015) 14: 55. https://doi.org/10.2174/1871527314666150116115414
Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders
MRI Abnormalities Associated with Mild Cognitive Impairments of Vascular (VMCI) Versus Neurodegenerative (NMCI) Types Prodromal for Vascular and Alzheimers Dementias
The Plastic Phenomenon Underlying the Associative Processes in the Addictive Properties of Diazepam and Other Psychoactive Drugs
Multipotent, Permeable Drug ASS234 Inhibits Aβ Aggregation, Possesses Antioxidant Properties and Protects from Aβ-induced Apoptosis In Vitro
Pharmacotherapy for Bipolar Depression: A Review of the Evidence
Current Psychiatry Reviews
Efficient In Vitro Refolding and Characterization of a New Peptide from the Scorpion Buthotus saulcyi Venom Produced in Escherichia coli
The Forgotten Cells: Role of Astrocytes in Mood Disorders During the Aging
Current Neuropharmacology
Nanocapsulated Ascorbic Acid in Combating Cerebral Ischemia Reperfusion- Induced Oxidative Injury in Rat Brain
GABAergic Modulation in Diabetic Encephalopathy-Related Depression
Microglial Senescence
Inflammatory Cytokines, Growth Factors, and Depression
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?
Alzheimers Disease: Interactions Between Cholinergic Functions and β- amyloid
Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage Score For Predicting Outcome
Current Neurovascular Research
Non-fatal Overdose with U-47700: Identification in Biological Matrices
Therapeutic Monoclonal Antibodies and Multiple Sclerosis: The Essentials
HspB8 is Neuroprotective during Oxygen Glucose Deprivation and Reperfusion
Untangling Alzheimer's Disease Clinicoanatomical Heterogeneity Through Selective Network Vulnerability – An Effort to Understand a Complex Disease
Molecular Insights into Mechanisms of the Cell Death Program:Role in the Progression of Neurodegenerative Disorders
Role of Complement Systems in IVIG Mediated Attenuation of Cognitive Deterioration in Alzheimer's Disease


text:
Mueller Investigator Personally Represented Ben Rhodes, Clinton Foundation
By: Bre Payton
An investigator involved in special counsel Robert Mueller's team investigating President Trump personally represented the Clinton Foundation and was Ben Rhodes's attorney.
Bre Payton
An investigator involved in special counsel Robert Mueller's team investigating President Trump served as a personal attorney for Obama administration officials, represented the Clinton Foundation, and even donated thousands of dollars to Hillary Clinton's campaign.
Fox News's Laura Ingraham revealed Tuesday night that Jeannie Rhee — whom Mueller hired over the summer to probe President Trump and his associates over charges they worked with Russian officials to steal the election from Hillary Clinton — donated the legal maximum to the former secretary of state's presidential campaign in 2015 and again in 2016. Rhee has also donated more than $16,000 to Democrats since 2008.
Rhee also served as the personal attorney for Ben Rhodes, a deputy national security adviser for President Barack Obama who infamously bragged about lying to reporters to dupe lawmakers and the public into supporting the Iran Deal.
Earlier this week, news broke that the FBI has dismissed an agent, Peter Strzok, for sending anti-Trump text messages to a co-worker he was allegedly having an affair with. Strzok was one of the two FBI agents who interviewed Trump's former national security advisor Michael Flynn. On Friday, Flynn pled guilty to lying to the agency in those interviews about meetings with then-Russian ambassador Sergey Kislyak last December.
Watch the latest video at video.foxnews.com
Bre Payton was a staff writer for The Federalist. She wrote on subjects ranging from Kanye West to Supreme Court rulings, to 2016 and breaking news. She appeared on Fox News, MSNBC, CNN, NPR, BBC World News, among others, and her work was featured in The Wall Street Journal, The New York Times, Daily Signal, and WORLD Magazine, to name a few. She had also worked as a reporter for Watchdog.org and received her degree in Political Journalism from Patrick Henry College.
Ben Rhodes
Bob Mueller
Jeannie Rhee
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31,271. The authorities rounded up Mau Mau suspects thousands at a time herding them into vast internment camps. (England & Great Britain & Empire & Kenya) ibid.
78,115. The creature has a muscular body, high shoulders and a powerful sloping back. (Kenya & Cryptozoology) ibid.
78,116. It is our belief that the Nandi bear seen today is a large hyena. (Kenya & Cryptozoology) ibid.
78,118. The legend adds that the bodies of the dead were thrown into abyss as the fighting raged on. ibid.
78,119. Voices singing and a visible ball of light – that's the craziest clash of stuff I've ever seen and heard in one place. ibid.
78,121. They had killed sixty-one including a dozen children and three pregnant women. (Kenya & Terrorism & Al Qaeda) ibid.
112,060. The Mungiki have a reputation for using beheadings, skinnings and dismemberment as their chosen methods of execution … The Mungiki claim to have millions of members. (Gangstas: Kenya & Kenya & Riots) ibid.
112,061. When I met the leaders they were a slick outfit, they were very convincing … They are highly organised. (Gangstas: Kenya & Kenya) ibid.
112,062. The poverty is just shocking. (Gangstas: Kenya & Kenya) ibid.
112,063. I've come to meet the glue kids: these kids are addicted to solvents and they are just some of the 350,000 kids that are homeless in Kenya … That number is expected to increase dramatically … I was truly horrified. (Kenya & Addiction) ibid.
112,064. Mothers who are heavily addicted giving the glue bottle to their toddlers. (Kenya & Addiction) ibid.
113,981. This is the story of unheeded warnings, missed opportunities, the slaughter of innocence. Osama bin Laden's war on the West is the latest bloody chapter in the Age of Terror. (Terror & Kenya & Bomb) ibid.
120,968. Three and a half tons of documents were destroyed in the run-up to independence. ibid.


text:
package yushijinhun.authlibagent.util;

public final class HexUtils {

	private static final char[] HEX = "0123456789abcdef".toCharArray();

	public static String bytesToHex(byte[] bytes) {
		char[] str = new char[bytes.length * 2];
		int pos;
		for (int i = 0; i < bytes.length; i++) {
			pos = i * 2;
			str[pos] = HEX[(bytes[i] & 0xf0) >>> 4];
			str[pos + 1] = HEX[bytes[i] & 0xf];
		}
		return new String(str);
	}

	public static byte[] hexToBytes(String hex) {
		char[] chars = hex.toLowerCase().toCharArray();
		byte[] bytes = new byte[chars.length / 2];
		for (int i = 0; i < bytes.length; i++) {
			int pos = i * 2;
			bytes[i] = (byte) ((hexCharToByte(chars[pos]) << 4) | hexCharToByte(chars[pos + 1]));
		}
		return bytes;
	}

	private static byte hexCharToByte(char hexChar) {
		if (hexChar >= '0' && hexChar <= '9') {
			return (byte) (hexChar - '0');
		} else if (hexChar >= 'a' && hexChar <= 'z') {
			return (byte) ((hexChar - 'a') + 10);
		} else if (hexChar >= 'A' && hexChar <= 'Z') {
			return (byte) ((hexChar - 'A') + 10);
		}
		throw new IllegalArgumentException("not a hex char: " + hexChar);
	}

	private HexUtils() {
	}

}


Besides boxed goods, we know that equipment comes in different shapes, sizes and weights and are happy to configure gear mounts and equipment racks to assist your storage needs inside the container. If you have multiple staff working with rolls of cables, assorted work gear or heavy tools there should be a place for everything, safely mounted in the container on walls, saving floor space. Equipment that requires different levels of access control can be racked behind a security partition.


Amid the furor of the August 1 Bitcoin Fork, another interesting thing happened. The individual(s) behind the WannaCry ransomware attack started to empty their bitcoin wallets. The $140,000 worth of bitcoin they originally collected gained about 20% more in value during the split, and it was around that time that the virtual money started to move.
The activity was detected by Keith Collins of Quartz, who used a bot to watch for movement in the accounts. The bot observed the initial withdrawal of $70,000, which was then followed by additional amounts from other bitcoin wallets until all the money was gone.
Posted in Bitcoin, Cryptocurrency and tagged Bitcoin, Bitcoin Fork, bitcoin split, BTC-e, Steve Prentice, ValueWalk, WannaCry on August 4, 2017 by Steve Prentice.
Here are the most common objections to establishing a time management plan. See how many fit your mindset, or that of your colleagues.
This is an excerpt from my book, Cool Time: A Hands-On Guide for Managing Work and Balancing Time. If you want to learn more, please check out the Books page on this website.
Nobody appreciates being told how to act. Books on time management often force people to adopt techniques that go against their natural preferences, such as using a certain type of agenda, or doing certain things at certain times, in short, taking some of the fun out of life. Such fears and objections are perfectly sound, since people are conservative by nature. Change generates fear of the unknown, a fear of failure or of being seen to fail. This fear goes back all the way to the early days of our evolutionary history. Like the rest of our metabolism, it cannot be changed so much as understood and properly channeled.
The purpose of Cool-Time is to help you take the principles and apply them to your environment, culture and preferences in the most comfortable and proactive way possible – the one with the greatest payoff.
In fact, it's perfect for spontaneity, since it allows for the existence of "free time." By keeping the day in order and with a day plan in mind, spontaneous activities can occur without endangering or forgetting the other activities and priorities of the day. Being able to take some time for yourself is essential, but in the real world this can only truly work if the other tasks are understood, prioritized and accounted for.
The best way to be spontaneous in life is to plan to be spontaneous.
Everyone has a routine. Some routines are just more obvious than others. A person who does shift work, or someone who has a fixed list of tasks to accomplish day in and day out, has her routine clearly mapped out. However, we all have a routine by the very nature of the 24-hour clock and our circadian rhythms.
The first stage in effective time management is to step back, observe the constants and standards in your life, and then recognize the routine in which you operate. Then, like a fish suddenly discovering the water in which it lives, the patterns of your existence will emerge for you to manipulate and finesse. If you can't identify any distinct routine happening daily, step back and observe your activities over a week or a month. Your routine will emerge, and will serve as the foundation for your time management plans.
Our environment is too different. Everyone says that. Everyone thinks their business has unique pressures and requirements that make any time management regimen unworkable. Whether you work in the public or private sector, or a not-for-profit; whether you are a student, a homemaker, between assignments, a manager or an up-and-coming professional, you are in the business of selling "you" to other people. Also, no matter what activity you are involved in, there is someone, somewhere who does it better, or did it better. There is always opportunity for improvement, advancement, and refinement. It's up to you to identify how to make that happen.
Actually, you do have the time, it's just been assigned to other tasks. Time is neither made nor found, simply rearranged, much like the Law of Conservation of Energy we learned in Physics 101. Let's put it this way. If you are a working parent, and your child's school calls to say that she is sick and needs to see a doctor, there's not much on this earth that would stop you from going to her side right away. Even if you're not a parent, a sudden toothache or a broken finger is going to change your schedule for the day pretty quickly. Most of your colleagues will be accommodating, and the work will get done later. The point is, time can be found when it's important enough. The benefits of Cool-Time are tangible. They translate into money, health, satisfaction, and control. Cool-Time is important enough to make the time.
Nobody really works better under pressure, since pressure immobilizes higher brain functions and replaces them with fight-or fight reflex. In short, pressure instills mental paralysis. What last-minute people do well is to compress their action and energy into a smaller block of time, not letting a project drag on, but keeping it on time.
Hard work without planning is like chopping a tree with a dull axe. Huge amounts of energy go misspent, and sometimes it will not yield any product at all. You cannot make bread twice as fast by putting in twice as much yeast or by setting the oven twice as high.
I've used it for years. If you have a system and that system works for you and your colleagues in a satisfactory way, then that's great! Congratulations! Still, there is always opportunity for improvement. Take a moment to observe your current work environment and note whether certain tasks or procedures could be tightened up to win you back some more time. To be able to embrace change, it is necessary to confront your objections. Note any feelings or resistance you may feel towards continuous improvement, and assess whether your arguments can be countered, or whether your current way of doing things is adequate.
Check out my book, Cool-Time. Information on ordering is available on the Books page.
Posted in Steve Prentice, Steve Prentice - Author, Time Management and tagged Cool-Time, Organization, Productivity, Steve Prentice, Time Management on April 13, 2017 by Steve Prentice.


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Photos and Video were submitted and uploaded by Stephi, 35 years old. Job: (Supervisory Wastewater-Treatment-Plant Operator). From Nicasio, California.


Is NeNe Leakes Freaking Out Her 'Apprentice' Co-Stars?
Supermodel Niki Taylor was taken aback by NeNe's over-the-top personality.
We know The Real Housewives of Atlanta's NeNe Leakes had her share of in-your-face moments with Kim Zolciak in the past. And Dwight. And Gregg. And... well, you get the picture.
Now her Celebrity Apprentice co-star Niki Taylor admits to Access Atlanta that initially "[NeNe] came on a little bit strong." But soon the supermodel came to realize that first impressions can be deceiving and gushes, "There's a very sweet side to NeNe." Aw, shucks.
Donald Trump's boardroom will get its latest round of star power on March 6 when Gary Busey, Meat Loaf, La Toya Jackson, Mark McGrath, David Cassidy, Dionne Warwick, Star Jones, Lisa Rinna, Lil Jon, and more flash their business savvy. How will NeNe size up against the competition? "She works hard," Niki promises. "She brings it."
Niki doesn't hint at how long the resident 'Wife sticks around Trump Tower, but she's not picturing NeNe as a behind-the-desk girl. "I told her she needs her own show."
Maybe, but for now, NeNe has her fellow ATL Housewives to contend with -- the ladies go toe-to-toe on February 13 at the Real Housewives of Atlanta reunion.
What's everyone else saying about NeNe? Follow the buzz on all your favorite Bravo stars with our Tweet Tracker.


A vintage 9k yellow gold 0.35 Carat diamond cluster ring.
This vintage 9k yellow gold ring has 0.35 Carat of 15 brilliant cut diamond stones in a three tier cluster setting.
Hallmarked 9K DIA for diamonds and makers mark.