text:
Clerks 2
2006 R 1h 37m Blu-ray / DVD
Picking up 10 years after their original misfit misadventures, director Kevin Smith revisits the doldrums and daily routines of New Jersey's minimum-wage employees in this sequel to his career-defining first film, Clerks. This time, seasoned slackers Dante (Brian O'Halloran) and Randal (Jeff Anderson) find themselves working behind the fast-food counter at Mooby's after a catastrophe drives them away from their previous dead-end jobs.
Brian O'Halloran, Jeff Anderson, Rosario Dawson, Trevor Fehrman, Jason Mewes, Kevin Smith, Ethan Suplee, Jason Lee, Kevin Weisman, Earthquake, Wanda Sykes, Ben Affleck
Comedy, Indie Comedies, Cult Comedies, Late Night Comedies
Witty, Raunchy
Blu-ray• DVD
Widescreen 1.85:1
English, Spanish (Neutral)
English: Dolby Digital 5.1
Widescreen Anamorphic 1.85:1
R - Under 17 requires accompanying parent or adult guardian. Contains some adult material. Parents are urged to learn more about the film before taking their young children with them.
Common Sense rating OK for kids 17+
Common Sense Note
Parents need to know that this film is not for kids. The dialogue is rife with obscenities (over 130 f-words, to start), as well sexual talk (including references to oral sex, bestiality, masturbation, homosexuality, and pornography) and brief images (tongue-kissing, visual suggestion of a man about to masturbate and then penetrate a donkey). A fast-food clerk urinates and puts flies in customer's food. Characters are arrested for hiring/watching a bestiality act.
Incessant sexual allusions, including crude slang for genitals and sex acts; a shot of full frontal male nudity, with penis tucked between legs; a hired performance (sex with a donkey) serves as joke/climax; explicit tongue-kissing; discussion of one-time unsafe sex (resulting in pregnancy); naked bottom (mooning); long discussion of "a-- to mouth" sex act.
Store burns down at start of film; knee to the crotch.
Over 130 f-words, plus other obscenities and sexual slang.
Best friends worry and argue over one's impending marriage; man admits cheating on his fiancee; characters taunt each other, dirty food they're selling, purchase a human-animal sex performance via the Internet; jokes about religion (especially Christianity).
Song lyrics refer to Pizza Hut, Dairy Queen, McDonald's.
Drugs / Tobacco / Alcohol
Jay and Silent Bob sell drugs and smoke dope; mentions of weed, coke, heroin; characters smoke cigarettes and drink liquor (Eli is drunk at end).
Not an issue
Depends on your child and your family
Parents strongly cautioned
Not appropriate for kids of the age
This information for parents is provided by Common Sense Media, a non-profit organization dedicated to improving kids' media lives.


Exercise mats are an easy way to achieve the most from your exercise routine, without having to spend a lot of cash. A well-designed training mat will grip the floor, making sure you have a "no slip" experience. Because of this you can give attention to your form rather than always keeping your footing.
Well made exercise mats are also easy to clean, give you a large footprint to work with, and get you look like a pro when you are enjoying yoga, Pilates, bodyweight training or any other type of exercise regimen. Let's take a look at 5 of the bestselling fitness mats you can find online, comparing and contrasting them so you can make the souwhich exercise mat nd purchasing decisions for your particular situation.
First and foremost, your fitness mat should have a large enough surface area for your workout. It should also stay put, gripping the floor and your feet. The HemingWeigh Extra Thick Foam Exercise Mat qualifies on both of those important points. Perfect for Pilates, yoga, bodyweight training, stretching and other exercise regimens, this oversized mat is also thicker than most at 5/8″.
That thickness, coupled with a unique resilient foam design, means your mat never stays compressed, and always returns to its original form after your workout. A built-in Velcro and nylon strapping system are on board for easy carry portability and space-saving storage.
At nearly 6 feet in length, the Sivan Health and Fitness 1/2-Inch extra thick yoga and Pilates mat is perfect for all sorts of exercise programs. That thicker than average design means fewer aches and pains in your knees and joints. And the particular dual surface construction grips the floor safely while allowing a comfortable feel to your feet.
Unlike some exercise and fitness mats, specially designed memory foam guarantees your mat never stays compressed, while also delivering a comfortable workout. Available in black, red and blue, this modern fitness mat is consistently a top 10 bestseller over at Amazon, where it enjoys a customer satisfaction rating of 4.5 / 5.0 stars.
This foam exercise mat from Valeo is large, comfortable, easy to transport and store, and grips the floor well. It is constructed of high-density, closed cell foam, meaning that it returns to its original shape quickly. This feature also means easy clean up with a damp cloth. Consider it 2 mats in 1 – the specially ribbed surface on the bottom side is perfect for keeping your mat in place.
The smooth top surface means a comfortable workout, with enough padding to limit injuries, aches, and pains. At 6 feet in length and 2 feet wide, it also provides plenty of space for your workout. Ranking consistently as one of the highest rated fitness mats on all of Amazon, your investment is also significantly lower than many of the other bestsellers.
If you have ever worked out on a small fitness mat, you know how frustrating it can be. You are consistently overreaching the mat, slipping and sliding on the floor. With the Extra Wide and Extra Long 1/4" Deluxe Yoga Mat from Yoga Accessories that is never a problem. At 3′ x 7′, this is one of the largest, and therefore bestselling, exercise mats you will find anywhere.
The price tag is attractive, considering much smaller mats can easily cost more. Available in your choice of black, blue or purple, this extra large mat works perfectly for yoga, Pilates, and other stretching and toning exercises.
Everlast has been making quality gymnasium and fitness gear for decades. This 2′ x 6′ folding mat is up to twice as thick as other Pilates and yoga mats. This protects your joints and bones, while the folding design and built-in transportation handles make it easier to transport and then "roll up" mats.
There is no wonder the Everlast 2′ x 6′ Folding Mat is one of the highest rated exercise mats (4.7 / 5.0 customer satisfaction stars) on Amazon. Available in your choice of black or blue.


text:
By late 2010, mobile devices will have 5 times iPhone 3GS performance
By Jon Jordan, Contributing Editor
If you want to know what's really going on in the world of mobile devices you have to talk to the people designing the silicon that's powering the devices being designed for late 2010 and beyond.
That means companies such as ARM, Qualcomm and UK 3D experts (and part owned by Apple) Imagination Technologies.
It's just announced its PowerVR designs have been used in over 250 million devices including the iPhone and iPod touch (models from 2G to 3GS), as well as other signature phones such as Nokia's N95 and N900, Samsung Wave and Sony Ericsson's Satio.
It's also powering Texas Instruments' new OMAP 4 chip platform, which is now being sampled and will be in devices released in late 2010.
iPhone gets dated
"We're looking at a five fold increase in performance with OMAP 4 compared to the current iPhone 3GS-class of devices," says David Harold, Imagination's head of PR.
This is due to chip design that include dual ARM 9-family CPUs combined with Imagination's PowerVR SGX 540 3D hardware.
In keeping with the company's naming convention (first digit family, second digit number of pipes), this includes four processor pipeline, proving plenty of overhead for handling intensive tasks such as OpenGL ES 2.0 shaders.
However the next generation of devices, due 2011, will be using the SGX 543 design, which is designed to be used as a multiple cores, from two up to 16 integrated into the CPU silicon.
At its maximum, this will see a 32-fold increase in graphical performance over the 3GS generation; something that will be represented in 720p displays on mobile devices, as well as the ability to output 1080 resolution imagery to largescreen displays.
The hardware that will power the future PlayStation 3-in-your-pocket is being already designed.
Jon Jordan
A Pocket Gamer co-founder, Jon is Contributing Editor at PG.biz which means he acts like a slightly confused uncle who's forgotten where he's left his glasses. As well as letters and cameras, he likes imaginary numbers and legumes.
News Mar 17th, 2010
Tap Me CEO Hernandez reveals iPhone gaming advertising platform iComplishments
Why Namco's UniteSDK could shake up social gaming networks
GDC 2010: How Palm is pushing mobile gaming with its C/C++ PDK
FreeAppCalendar discovery website goes live
GDC 2010: ngmoco's Neil Young on We Rule's early Canadian success
News 1 hour, 28 minutes ago

redpajama_set_name: RedPajamaCommonCrawl


We are looking for someone with parenting experience, to work 18.5 hours per week. To train and support volunteers to work in the home providing practical support to families. They should also have experience of working with pre-school children. The ideal candidate will additionally have leadership qualities and be abreast of multi-media technology (working within websites, mobile phones and Apps).


Are you born before 25-04-2001 ?
You will access a version whose content has been restricted by the legislation in force in your country.
First of all discreetly, without a word spoken about the restructuring of the parcels, now certified organic and an important part in the production of a great wine.
The 2017 vintage is the first to bear this label.
Organic preparations, multi-purpose plant species, the use of animal draught cultivation and manual labor – everything is done in relation to the natural environment, including the changing seasons and the local fauna. The vineyard is carefully tended to, as if a sophisticated work of art.
Quanou, Nola, Marquise and Varyx are the names of the four sturdy draught horses, representing different French breeds: Breton, Percheron and Mulassier from the Poitou area. They are used to earth up and slightly spike the soils in autumn and spring. For a period of 4 to 5 hours, they slowly make their way through the parcels at Château Jean Faure, to aerate the earth and promote microbial activity.
Château Jean Faure's stable is an avant-garde return to the past – a total commitment.
The teams at Château Jean Faure with conviction and pragmatism, drawing from traditional practices, the required resources to implement gentle and efficient sustainable vine-growing techniques.
Humility requires twice as much work on a daily basis: the treatments depend upon the humidity, the climate and the seasons. Plenty of vigilance and monitoring is required: it is necessary to react quickly and never let your guard down.
The use of preventive products, natural concoctions, the lunar calendar, disbudding, and green pruning are practices, helping the vine to defend itself. Their perfect interaction is fully expressed by this magical terroir.


text:
Brawl Costume Manager
=========

Brawl Costume Manager is a .NET application for managing the costume files and
corresponding CSS (character select screen) portraits for each character in
Super Smash Bros. Brawl.

This repository has been merged into BrawlManagers.
https://github.com/libertyernie/BrawlManagers

redpajama_set_name: RedPajamaGithub


Buckeye DAMA offers affordable Individual and Corporate membership plans.
The lowest level corporate membership breaks down to a cost of $60 per person or $15 per half-day session. Not only is this a great value, the quarterly meetings are right here in central Ohio and lunch is provided free of charge.
To offset the cost to our membership, the chapter works with companies to sponsor the chapter on a yearly basis or to sponsor individual meetings. In addition, due to our non-profit status many of our speakers are willing to reduce their normal speaking fees.
Please note that all memberships are 12 month terms.
For more information, please email the VP of Membership.


text:
Home Investing
Vanguard review: A low-cost option for long-term investing
in Investing
The robo-advisor service Vanguard Digital Advisor requires a minimum deposit of $3,000 to enroll. There's also up to a 0.20% annual advisory fee (although their is a fee waiver for the first 90 days after account opening) to use the automated investing platform.
And, lastly, though there is a $20 annual service fee for Vanguard IRAs and brokerage accounts, this can be easily waived if you opt into paperless statements.
Cramer advises investors to sell stocks in companies that don't make money
stands out as a rather low-cost option for those looking for a brokerage account. It has a large selection of ETFs and mutual funds which appeals to long-term investors who want to see their money grow.
whose automated investing platform has zero account management fees and no minimum requirements. It offers a broad range of low-cost ETFs and will automatically rebalance your portfolio on a quarterly basis. Read our
Unless all three of those conditions are true, it's nearly always a good idea to pay off your debts rather than try to manage through them....
Investors should dump their stocks in companies that aren't profitable, CNBC's Jim Cramer said Thursday, one day after the Nasdaq entered correction territory. "I don't think it's as dangerous, obviously...
J.P. Morgan Online Investing Raises the Bar on New Account Rewards
Existing customers will receive a $50 bonus deposited to their account for each person they recommend who opens a Self-Directed Investing account through the refer-a-friend link. Existing...
Cramer's Investing Club: We are making a few sales Tuesday morning to lock in big gains
hey say it takes money to make money, and that holds true within the realm of investing. After all, you can't build a portfolio without money....
The Future Of ESG Investing Could Truly Deepen Our Impact
SG investing has come a long way over the past few decades. In the early stages, it was largely an exercise in exclusion, as investors constructed portfolios that...
From Cancelling Student Loans To Student Loan Forgiveness, More Student Loan Relief Could Look Like This
Don't count on that tax refund yet. Why it may be smaller this year
10 Moves That Will Make Your Credit Score Soar in 2022
Are We Bullish Enough?
Janet Marie (Kathcart) Waters Uncategorized


The work of Zaiwen Wen was supported in part by in part by NSF DMS-0439872 through UCLA IPAM.
The work of W. Yin was supported in part by NSF CAREER Award DMS-07-48839, ONR Grant N00014-08-1-1101, the U. S. ARL/ARO grant W911NF-09-1-0383, and an Alfred P. Sloan Research Fellowship.
The work of Yuan Shen was supported by the Chinese Scholarship Council during this visit to Rice University.
The work of Yin Zhang was supported in part by NSF DMS-0811188 and ONR N00014-08-1-1101.


Growing up, I hated nature. Living in the woods of New Hampshire by the time I was twelve, in a town with one (blinking) traffic light, I preferred staying indoors if at all possible; reading, or singing into a brush in my mirror to a Whitney Houston record, or talking on the phone to my junior high boyfriend.
But in high school, I read Walden and fell in love with Thoreau's view of nature. His meditative take on the seasons and his insistence on living a life where you notice what is around you really struck me. I underlined too many of its passages to count with a hot pink fountain pen and kept the book through my dozens of moves since. And I've had a soft spot for Thoreau ever since that time.
When I moved to California from the East Coast, I finally fell fully in love with nature, myself. Something about winter rarely getting below fifty degrees really worked for me, after a lifetime of dreading winter. Though I swore I wouldn't before I moved here, I began to love hiking (Northern Californians loooove to hike, and I was not immune to its charms). I love climbing to the top of a tall hill and seeing the ocean. It's a sight that never ceases to surprise and delight me. I take more pictures of sunrises and sunsets than maybe anything other than my children. Loving nature has become part of who I am.
But today I sit in my office with what is normally a view of the Golden Gate Bridge, I just see grey. The air is filled with smoke and ash due to our location in relation to one of California's multiple burning wildfires right now. Last year we came perilously close to losing our house in the Montecito fires, and we know many people who have lost or nearly lost their homes in just the past two years. California is in peril. Deadly raging fires have suddenly become the norm each year, and the loss of life and property is stunning and heart-breaking.
My heart hurts for my state. The state that taught me, finally, to love all that the natural world holds. The state whose beauty changed me.
I want better for my state, for my children who are growing up as Californians, and for all the people who live here. I hope that we can find solutions to this problem that has become wildly exacerbated in the past few years, due to the rising of temperatures here.
And, in the meantime, I am grateful that life has taught me to love and appreciate nature. I look forward to when the skies clear so that I can appreciate the sunset again.


Diversion: Route buses coming from BIRKIRKARA BY-PASS going towards MATER DEI will have to divert straight to MATER DEI MAIN ENTRANCE without serving UNIVERSITY INTERCHANGE and the ring road which connect UNIVERSITY with MATER DEI.
Diversion: Route buses coming from VALLETTA going towards UNIVERSITY and MATER DEI will have to divert straight to MATER DEI MAIN ENTRANCE without serving UNIVERSITY INTERCHANGE and the ring road which connects UNIVERSITY with MATER DEI.
Diversion: Route buses coming from the south going towards UNIVERSITY and MATER DEI will have to divert straight to MATER DEI MAIN ENTRANCE without serving UNIVERSITY INTERCHANGE and the ring road which connect UNIVERSITY with MATER DEI.


Third-person singular (él, ella, also used with usted?) present indicative form of signar.
Informal second-person singular (tú) affirmative imperative form of signar.
This page was last edited on 3 February 2019, at 08:39.


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Medical Cannabis: History, Benefits, Use and Effects
Melissa Sherrard
Medical marijuana or medical cannabis is a cannabinoid drug that has been synthesized from the cannabis plant for use in medical treatment of patients in many countries around the world. While there are many arguments on the benefits of cannabis in medical applications, the medicine form has not been fully tested for its full potential due to the many restrictions in both production and governmental regulations in the various countries where it has been legalized for use.
Complete medical benefits are not fully clear
There is limited evidence available that the use of medical cannabis can help to reduce nausea and vomiting during chemotherapy treatments for cancer, and can improve the appetites of people with HIV/AIDS. It is also known that it can severely reduce chronic pain and muscles spasms in patients with severe muscular injuries. And while there is some evidence to suggest that the short-term use of cannabis can increase the risk of some minor side effects, the long-term effects are yet unclear. More research still needs to be completed before such quantifiable evidence can be released. However, major concerns among medical practitioners include memory and cognitive problems, the risk of addiction, as the addictive qualities are neither proven nor disproven yet, and the risk of it accidentally being taken by children. The effects on children under 12-years-old are unconfirmed due to restrictions on testing.
How to administer medical cannabis
As a drug, cannabis can be administered in many ways, including using lozenges, dermal patches or oral/dermal sprays, as well as by vaping a synthesized liquid, smoking of the dried buds, eating cannabis-inclusive foods (where the cannabis has been cooked into the food), and ingestion in the form of medical capsules.
History of medical cannabis from past to present
Cannabis has been used throughout history as both medicines and recreational or psychoactive use. Its origins are believed to have been in Taiwan around 10,000 years ago, where hemp seeds were used as food. It is fair to believe that they would also have discovered the medicinal uses of the plant. Pharmacologist and emperor, Shen Nung, wrote a book that included some of the medical benefits of cannabis in 2737BCE, and he recommended the drug for several illnesses and ailments, including gout, rheumatism, constipation, and absentmindedness. Ancient texts from India also confirm the use of cannabis for its psychoactive properties and its use in medical treatment, including as a pain relief during childbirth. And in ancient Egypt and ancient Greece, there is extensive evidence of its use, and was even mentioned in the famed Ebers Papyrus from 1550BCE. In more modern times, there is extensive evidence of its use in medicine right up to the late 18th century.
Throughout history, cannabis has been used for its medicinal properties, and its use is believed to have started over twelve thousand years ago in Asia. With hemp seeds being a natural part of Asian foods, ancient physicians soon discovered that the plant had many other useful properties, especially in the areas of medicines and narcotics. As far back as 2900BCE, there are texts that quote the use of "Ma", the Chinese word for cannabis, as a popular medicine that possessed both yin and yang. In the 27th century BCE, the Emperor Shen Hung wrote of the medicinal properties of cannabis in his works. Considered to be the father of all Chinese medicine, his writings included the fact that cannabis was useful in the treatment of gout, constipation, rheumatism, and forgetfulness.
Chinese women creating medicine from cannabis plants. (herb.co)
In Egypt, in the 12th century BCE, cannabis was a popular medicine for treating glaucoma, inflammation (hemorrhoids) and other ailments, and pollen from the cannabis plant was found in the wrappings of the mummy of King Ramesses II when his tomb was finally opened in 1995. There have also been extensive mentions of its use in several ancient papyri spanning a period of over a thousand years, including the Ebers Papyrus from 1550BCE, the Ramesseum III Papyrus from 1700BCE, the Berling Papyrus, that is dated from around 1300BCE, and the Chester Beatty Medical Papyrus from 1300BCE.
Scripture depicting Ancient Egyptians using cannabis. (herb.co)
In India in around 1000BCE cannabis was used as an anti-phlegmatic and anesthetic, and was administered in milk. India has always had close ties with the use of cannabis as a medicine, and "bhang", the medicinal name for the cannabis plant in India, has long been a regular medicine for many ailments. Ancient Indian text shows that they also used bhang for the treatment of dysentery and sunstroke, as well as to quicken digestions and for other stomach ailments. In around 600BCE, an Indian medical work known as the Ayurvedic treatise of Sushrita Samhita cited cannabis as a cure for leprosy.
On and on throughout history, there have been medical references to the use of cannabis as a healing medicine. In Greece, it was used for earaches and inflammation, and the Greek physician, PedaniusDioscorides, who was a doctor with the Roman Legions, added it to his book entitled De Materia Medica (On Medical Matters) in AD 70, which became the most important medical tome for the next 1500 years. Its medicinal properties are even extolled by the Roman scientist and historian, Pliny the Elder, as being used to "ease cramped joints, gout too and similar violent pain" in his book, Naturalis Historia, in AD 79.
In ancient Persia, the famous polymath, Avicenna, (Ibn Sina)wrote about the medicinal properties of cannabis many times in his works, and his contributions to medicine were hugely influential throughout Europe during the medieval and renaissance period. His texts tell of his use of the whole plant for its medicinal properties, using seeds, roots, and leaves for both internal and topical treatments. His works often refer to it as the "juice of cannabis leaves", and he would mix it with other herbs and plants to make concoctions to treat a range of illnesses. The works of Avicenna were so influential in early western medicine that cannabis was referred to in Brice Bauderon's 17th-century medical work, The Pharmacopoeia of Bauderon, as "Cannabis ex Avicenna".
In modern medicine, cannabis has been used regularly to treat muscle spasms, stomach cramps, and general pain since the early part of the 19thcentury. Its introduction to western medicine was attributed to the Irish physician, William Brooke O'Shaughnessy, who was famous for his work in pharmacology, chemistry and his research that led to intravenous therapy. After his return from India, he began the first ever clinical trials into the medicinal benefits of cannabis, using the recipes he had learned from the Ayurvedic physicians. In 1839, he produced the first concise case studies of his treatment of patients suffering from rheumatism, cholera, tetanus, and hydrophobia, which showed that the cannabis tinctures he developed had significant effect on the ailments. And the personal physician of Queen Victoria, Sir Robert Russell, wrote extensive papers on the benefits of cannabis and recommended its use as a tincture in the treatment of dysmenorrhoea (menstrual cramps).
O'Shaughnessy's clinical trials produced results that had many physicians of the time clamoring to try this new "wonder drug", and between 1839 and 1900 over 100 papers were written on the subject, as chemists worked to identify and isolate the active principles of cannabis, a goal not achieved until 1964, by Dr. Raphael Mechoulam. A Professor of Medicinal Chemistry at the Hebrew University of Jerusalem, he was the first to identify delta-9-tetrahydrocannabinol (THC), as the main psychoactive component of cannabis. He was also the first to synthesize THC.
In 1850, cannabis was included into the United States Pharmacopeia, the official government authority for all prescription medicines in the U.S. Cannabis was listed as a treatment for numerous illnesses and ailments, including neuralgia, tetanus, typhus, cholera, rabies, dysentery, alcoholism, opiate addiction, anthrax, leprosy, incontinence, gout, convulsive disorders, tonsillitis, insanity, excessive menstrual bleeding, and uterine bleeding. Pharmaceutical companies patented marijuana tinctures which were sold by pharmacists under prescription from doctors. It was removed from the US Pharmacopeia in 1942, finally losing the mantle of being a legitimate medicine.
In the 1970s, cannabis was synthesized for use as a drug in the United States, and approved by the Food and Drug Administration (FDA) under the name Marinol. In 1978, a new program was established in the United States and run by the federal government. The Compassionate Investigational New Drug (CIND)program allowed a small number of people with severe illnesses to use medical marijuana as a treatment. This small group of people was suffering from illnesses that included Multiple Sclerosis, AIDS, Nail-patella Syndrome, Multiple Congenital Cartilaginous Exostoses, and Glaucoma. Of the ten patients that were prescribed with medical cannabis in the group, four are still alive and are still classed as active participants in the program.
In 1990, a senior investigator at the National Institute of Mental Health, discovered a connection between cannabis and certain receptors in the brain. This discovery helped scientists to better understand the effects of cannabinoids, which occur when Cannabis-based THC binds with these cannabinoid receptors in the brain. Cannabinoids (THC and CBD)are the chemical compounds produced from cannabis flowers, which can imitate the natural compounds found in the body, called endocannabinoids. These compounds work to maintain internal stability and health, and mediate communication between cells. Where there is a problem with endocannabinoids, unpleasant symptoms and physical complications can occur, which can be treated by the introduction of THC or CBD to the system.
On November 5, 1996, California became the first state to legalize cannabis for medical use. Proposition 215, as it was known, was an initiative to allow patients and primary caregivers to possess and cultivate cannabis for the treatment of AIDS, cancer, muscular spasticity, migraines, and several other disorders, with a physician's recommendation. But it was not until late in 1998 that three other states approved the use of medical marijuana, with ballots in Alaska, Oregon, and Washington. By the middle of 2014, 23 states plus the District of Columbia had passed laws allowing the use of medical marijuana, with three more states joining after the elections in November 2016.
22 years after its initial inception in 1978, the Compassionate IND program produced its only study on the effects of cannabis treatment on their selected patients in January 2000. The study showed that, despite the cannabis being provided by the government being "a crude mixture of leaf with abundant stem and seed components", there were definite benefits of cannabis medication in those patients. The conclusion of the study stated that "cannabis smoking, even of a crude, low-grade product, provides effective symptomatic relief of pain, muscle spasms, and intraocular pressure elevations" and that "clinical cannabis patients are able to reduce or eliminate other prescription medicines and their accompanying side effects." However, despite this conclusive evidence of the benefits of marijuana in cases such as glaucoma, and the 27 states and districts that have legalized its use for medical purposes, the federal government refuses to change its stance on the medical use of cannabis.
Medical cannabis use in modern society and cultures
The legal status of medical cannabis use varies around the world, from illegal to legal, and is dependent on the country in which it is being used. There is no internationally recognized legal status for both medical and recreational use of cannabis, although the number of countries where it is being legalized or decriminalized is continuously growing. As of this time, the countries where the medical use of cannabis or a THC preparation (capsule medication) is legalized are:
Some U.S. states (although it is still illegal under federal law)
The United Nations (UN) Single Convention on Narcotic Drugs (SCND) lists cannabis in Schedule IV, giving it special restrictions. According to Article 2 of the SCND, Schedule IV allows as follows:
"A Party shall, if in its opinion the prevailing conditions in its country render it the most appropriate means of protecting the public health and welfare, prohibit the production, manufacture, export and import of, trade in, possession or use of any such drug except for amounts which may be necessary for medical and scientific research only, including clinical trials therewith to be conducted under or subject to the direct supervision and control of the Party."
This means that the Convention allows individual countries to outlaw cannabis if they so wish, while still allowing its use in research and medical use as they see fit. It also means that any country or state allowing the use of medical marijuana operates a licensing system for all growers, manufacturers, marketers, and distributors. The total volume of cannabis should not exceed that required for their scientific and medical purposes.
Distribution of cannabis for medical use varies from country to country, and in the U.S., users can either grow it themselves or buy it from listed dispensaries. Vending machines are now being used in some states, and are being planned for use in Canada, and there is even a mobile app where you can order more in the San Francisco area.
As there is no full FDA approval for cannabis medication yet, medical insurance will not cover its cost of purchase for users.This is hoped for in the future if the federal government legalizes its use and it is approved by the FDA.
The recreational use of cannabis is still illegal in many countries around the world, with only a handful allowing it for personal, recreational consumption. However, this list of countries allowing the use of cannabis for medical and recreational purposes is increasing, as the research into the plant's use gets deeper, and the minimal adverse effects are legally recognized.
In the U.S. there are only two brand names for medical cannabinoids that are approved by the FDA, the same number as in Canada, and only nine other countries have approved the use of cannabinoids in medications.
There has been a lot of research into the uses and benefits of cannabis the in majority of countries where studies can be conducted. However, there is only limited study on certain aspects and parts of the plant and its properties, and no study of the whole plant has ever been initiated. Despite the new rules within the compliant U.S. states, the nation is not advancing in the study and research of the cannabis plants benefits due to the massive amounts of red tape involved in getting a study off the ground. Approvals are needed from the FDA, the Drug Enforcement Administration (DEA), and NIDA. Moreover, any other government agency involved in the prohibition or research of cannabis could halt the entire project at any time, especially the government's federal law enforcement agencies.
There is currently ongoing research around the world into the use of cannabis and cannabinoids in the treatment of cancer, dementia, diabetes, epilepsy, glaucoma, Tourette syndrome, and many other conditions. However, the research into its use as a beneficial medical drug is ongoing, and there are yet inconclusive results for the majority of studies.
In cancer, it is believed that the use of cannabis could have positive effects, and laboratory experiments have shown some small amount of anti-cancer effects from cannabinoids. However, there has been no full human trial or clinical study yet, and much of the current "evidence" available on the internet is "misleading" according to Cancer research UK. Nor is there any evidence that using cannabis can help reduce the risk of getting cancer. More research is still needed in these areas.
The same is still also true in cases of dementia, diabetes, epilepsy, and Tourette syndrome, although the studies in the latter have produced very conflicting results. Glaucoma has also been ruled out as a beneficiary of medical cannabis due to the side effects, the short duration of effectiveness, and lack of evidence of any long-term effects.
Studies and research are also ongoing for illnesses such as Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, bipolar disorder, digestive diseases, and many other illnesses. However, in the case of multiple sclerosis (MS), patients who took the substance orally or as a dermatological spray showed some relief in the normal muscle stiffness, and there is evidence to support it. The American Academy of Neurology - which has previously stated that the scientific evidence to support the use of cannabis in any form as a medicine for treating or alleviating neurological disorders was weak to failing – has published new guidelines on the use of cannabis tablets and sprays for the treatment of MS sufferers.
In psychiatry, studies have shown that cannabinoids such as cannabidiol, have shown high potential in the treatment of several psychiatric conditions, including depression, anxiety, and psychosis.
Marketed cannabis-based drugs
Cannabis elements are now being used in drugs, in the form of Tetrahydrocannabinol (THC) and Cannabidiol (CBD). While THC is the ingredient in cannabis that works on the cannabinoid receptors in the brain, CBD is the part of the plant that produces muscle relaxants, and works on the cannabinoid receptors in the body. These drugs are now available by prescription in the United States:
Sativex – A mouth spray which contains both THC and CBD, and is used in the treatment of MS and moderate to severe pain in cancer patients.
Drobinol/Marinol – A capsule form of synthetic Delta-9 THC, this drug is used as nausea and vomiting treatment in chemotherapy patients, as an appetite stimulant in patients with HIV/AIDS, and as an analgesic for neuropathic pain in MS patients.
Nabilone/Cesamet – A tablet form of wholly synthetic THC-like cannabinoid, it is used primarily to treat nausea and vomiting in chemotherapy patients.
Dexanabinol – A capsule that contains a synthetic form of THC with non-psychotropic properties. It is mainly used as a neuroprotector after heart surgery, and can be used to aid in the processing of memories after a traumatic head injury.
Cannabinor – A synthetic chemical compound of THC, it is used as an anti-inflammatory for the treatment of chronic pain.
Several other drugs are currently in either clinical trials or are still in the research and testing stages.
Medical uses of cannabis and cannabinoids
Medical cannabis has been proven to have several beneficial uses in medicine for the treatment of illnesses and ailments. The evidence in many cases is still undergoing conclusive testing, but studies are showing that its use in the treatment of several major illnesses has a beneficial effect to the patients, as well as treating many of the symptoms of the ailments. Testing for the full potential benefits of marijuana is still ongoing. While many other organizations have varied views on the medical use and legalization of cannabis, the FDA has stated that cannabis "does not meet the criteria for accepted medical use due to lack of evidence regarding safety and the high risk of abuse".
The use of medical cannabis for chemotherapy patients has been rated as having a significant effect in chemotherapy-induced nausea and vomiting (CINV) produced by the treatment. Studies have shown that cannabinoids can be more effective than traditional medications such as prochlorperazine, promethazine, and metoclopramide in controlling CINV.
The evidence that cannabis can be safely used in the treatment of HIV/AIDS patients for anorexia-associated symptoms is inconclusive and has been tainted by bias, small testing sizes, and the lack of conclusive, long-term data. However, it has been proven that cannabis can improve the appetites of HIV/AIDS patients to the degree where they are more easily able to eat and retain some intake of the energy and nutrients needed.
The treatment of chronic pain using cannabis has been proven somewhat effective, including neuropathic pain, fibromyalgia, and rheumatoid arthritis. A 2011 study showed that it was generally safe for use for chronic pain relief in the short-term, though there is very weak evidence of the benefits in cancer patients. However, smoked cannabis has shown better results than cannabinoids in reducing chronic, non-cancer pain in the short-term for around 20 percent of sufferers. In January 2017, a report by the U.S. National Academy of Science, Engineering, and Medicine showed there was substantial evidence to prove that cannabis was effective in controlling chronic pain in adults.
The studies around neuropathic pain relief are not yet clear, especially in severe cases of multiple sclerosis (MS), epilepsy, and motor neurons disease. A combination of cannabinoids with other medications has shown some relief in spasticity though it does not give significant changes in the ailments.
Posttraumatic stress disorder and depression
The evidence that cannabis can help with posttraumatic stress disorder (PTSD) symptoms is very tentative yet, but a study carried out by the University of Buffalo into the uses of cannabinoids in depression showed that it can stabilize moods and combat severe depression
Research from the Tel Aviv University, in Israel, has shown that cannabis can reduce the pain and tremors of patients suffering from Parkinson's Disease.
A study produced by the Scripps Institute on the effects of cannabis on Alzheimer's disease patients showed that the use of THC can reduce the progression of the disease. The use of THC can limit the formation of the amyloidal plaques in the brain that cause the illness by inhibiting the enzyme that produces them.
A 2012 study into the benefits of cannabis in MS patients showed that the drug can reduce the painful muscle contractions related to the disease (muscle spasticity) and relieve the pain in the lumbar region caused by the myeloid lesions on the spinal cord.
As was shown in the report from the Compassionate IND program, which contained four patients with glaucoma, cannabis has the effect of reducing intraocular pressure. More recent studies have shown that, in clinical trials, glaucoma patients experience relief on average within two hours of the administration of oral compounds of THC and CBD.
Adverse effects of cannabis and marijuana use
There is still very little conclusive evidence to suggest that cannabis and marijuana use is safe, although the typical adverse effects are not considered serious. The main adverse effects include tiredness, dizziness, cardiovascular, and some minor psychoactive effects. Tolerance to these effects can develop over a period of a few weeks to months, and the amount of cannabis used for standard medical treatments is believed to not cause permanent cognitive impairment in adults. However, long-term use in adolescents should be avoided, as they are more susceptible to impairment.
In the United States, and many other countries around the world, recreational use of cannabis is prohibited and illegal. There are some acute effects that have been shown to appear in regular users who smoke the plant, both on its own and with tobacco. Anxiety, panic attacks, reduced attention spans, loss of memory during intoxication, and minor psychotic episodes are well documented and usually resolve within minutes or hours of use. Reports of extended symptoms have been relatively small in comparison with the 455,000 estimated annual emergency room visits associated with cannabis use. While the use of cannabis must be implicated in the visit to an emergency room, it is often not the main cause of the visit. Most emergency room visits for drugs involves multiple drug abuse, and in 129,000 listed cases, only one was implicated as directly caused by cannabis.
Chronic use
Chronic use of cannabis as a recreational drug may cause severe effects such as bronchitis, subtle impairments in memory and attention, and a cannabis dependency syndrome. In most adults, any cognitive impairment is not persistent, and fades after abstinence from the drug. There have been very limited numbers of studies that have focused on the effects of smoking cannabis on the human respiratory system. While prolonged use can bring on the symptoms of acute bronchitis, it has shown no significant anomalies in lung functions.
While cannabis smoke is known to contain over fifty known carcinogens, including nitrosamines, reactive aldehydes, and polycylic hydrocarbons, it is not believed that light to moderate use increases the risk of airway or lung cancer. The risks of pulmonary complications are far lower in cannabis smokers than in cigarette smokers, and the carcinogens are not present when consumed using a vaporizer, in pill form, or when added to foods.
There is a major amount of suspicion surrounding the contribution of cannabis smoking to cardiovascular disease. In the studies that have been done, mainly outside the U.S., 97% of cases also smoked tobacco, so there was no formal association of cardiovascular disease with cannabis smoking.
The use of cannabis does not usually cause withdrawal symptoms in normal users when abstaining, and only 42.2 percent of heavy users showed any signs of withdrawal symptoms when quitting. Symptoms shown were normal symptoms, similar to quitting tobacco, such as cravings, irritability, boredom, anxiety, and sleep problems.
Cognitive effects
The studies in the long-term effects of cannabis on the cognitive functions of adults have provided very conflicting results. Some studies have found no lasting effects on previously long-term users on abstention, while other studies reflect long-term deficits in cognitive functions. These discrepancies may be due to the difference of the users, the heavy and prolonged use, and studies on the use of cannabis by adolescents. A 2003 study on the analysis of the previous studies concluded that there were only modest long-term cognitive effects in a small percentage of the study subjects, and that they were mainly limited to certain aspects of memory and learning in adolescents.
Doctors Can Now Prescribe Visits to the Museum


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Hi, I'm a developer based in Taipei, Taiwan. I have a passion for developing softwares, applications, games, websites, and anything about our life. Developing had been a necessary part of my life since my young age.
I love to make things unified and simple with quality and performance in mind. Despite technologies keeping forward, improving, and changing, I am still enjoying learning and trying them and embrace changes to improve myself.
© 2019 Yang Sheng Han. All rights reserved.


Description Only edition. 16 pp., 193:124 mm., usual light age staining, wide margins, stamps, upper title margins extended.. A very good copy bound in modern half cloth and marbled paper boards.
Description Dr. Simeon Leon Schwabacher (1819–1888), rabbi and preacher. Born in Oberndorf, Wuerttemberg, Germany, Schwabacher served as rabbi and preacher in Prague, Hamburg, Landsberg, and Schwerin. Later he went to Lemberg (1856–60) to act as preacher of the "enlightened" congregation, and in 1860 he was invited by the maskilim of Odessa, with the support of the governor of the town, Count Stroganov, to act as kazyonny ravvin. His sermons in German made him well known; he published several works of homiletics, introduced new practices into the Great Synagogue of the town such as a choir, and concerned himself with the organization of modern relief activities for the poor. He also established the vocational school Trud, a mutual aid society of Jewish shop clerks, a soup kitchen, an orphanage, and an old-age home. His ignorance of Yiddish constituted a barrier between him and the masses and with the rise of a Russian-speaking class of maskilim, his influence with the Jewish intellegentsia also declined. His opposition to Hibbat Zion also caused him to lose popularity within the community, and in 1887 Schwabacher was removed from his rabbinical office. During his 27 years as rabbi he made an important contribution to the shaping of the character of the Odessa community as the first modern community in Russia.


text:
Q: LocalTime range query with ObjectBox Would this work with ObjectBox?
class Hub {
    List<Schedule> schedules;
}

class Schedule {
    String day;
    LocalTime opens;
    LocalTime closes;
}

And then query those Hubs  which opens and closes during a specific day, say, query with this constraint:
new Schedule().builder()
    .day("Monday")
    .opens(LocalTime.parse("08:00")
    .close(LocalTime.parse("17:00").build();

So in this case we want to query for Hubs that are open on Mondays at 8am to 5pm.
How does this translate to Objectbox Query?

A: You can map LocalTime to a supported type like Integer, see https://docs.objectbox.io/advanced/custom-types. Then you can build a query with a less and greater condition on that Integer property.
Quick example:
box.query()
    .equal(Schedule_.day, "Monday")
    .greater(Schedule_.opens, 800 - 1)
    .less(Schedule_.closes, 1700 + 1);

redpajama_set_name: RedPajamaStackExchange


text:
This Week in Amherst History: September 18, 1967
"[The faculty chose] to reduce the number of categories into which a student can be placed, to get away from the fine distinctions between 83 and 84 and set up a single value for failure," said Dean of the Faculty Prosser Gifford. "There are at present 59 different ways of failing."
"The grades earned under the old grading system stand and will not be affected by the new grading system," said Registrar Robert F. Grosse. Students' cumulative averages, however, were converted to conform to the faculty vote. An unintended result of the conversion was that it was possible for a student to get a cumulative average for which there was no corresponding letter grade.
The faculty also voted to only report grades of D or F on the mid-semester grade report, in essence eliminating mid-semester grades. The faculty had not voted on the method for determining the student's rank-in-class.
Because the grading scheme changed while they were at Amherst, transcripts of students in the classes of 1968 through 1970, had a description of "both grading systems, the course grades as given under each grading system and an explanation of the approximations made in the conversions of the cumulative averages," The Student reported.
Thoughts on Theses: Lianbi Ji
Lianbi Ji is an English and mathematics double major who wrote theses in both subjects. Her English thesis focused on the writings of the Chinese writer Lu Xun, and her math thesis studied elliptic curves. She also has a passion for education — having volunteered to teach in China, India and
Ashley Chang May 5, 2021
College Hosts Moderna President Stephen Hoge '98 in Virtual Event
The college hosted President of Moderna Stephen Hoge '98 on Friday, April 23 as a part of the virtual Stories in STEM event series. The Cambridge-based biotechnology company has experienced tremendous growth since the pandemic began, as it has developed one of the world's most effective vaccines against Covid-19.
Sam Spratford Apr 28, 2021
Covid Vaccinations Mandated for Students Returning in Fall 2021
The college will require all students to be fully vaccinated against Covid-19 before returning to campus for the Fall 2021 semester, the President's Office announced on Friday, April 23. In the letter addressed to students, faculty and staff, President Biddy Martin relayed that more information will follow concerning how
Sophie Wolmer '23 Apr 28, 2021


text:
Team Tokai wins 2011 World Solar Challenge
Team Tokai wins 2011 World Sol...
The Tokai University Team has taken out the 2011 World Solar Challenge (Photo: Gizmag.com)
Team Tokai has just reached the "Finish of Timing" checkpoint in the 2011 World Solar Challenge (Photo: Hideki Kimura)
Team Tokai celebrates victory in the 2012 World Solar Challenge (Photo: Gizmag.com)
The Japanese Tokai team celebrates victory in the 2012 World Solar Challenge (Photo: Gizmag.com)
Team Tokai wins 2011 World Solar Challenge (Photo: Gizmag.com)
Team Tokai approaches the finish line in the 2011 World Solar Challenge (Photo: Gizmag.com)
The finish Line in Adelaide, South Australia (Photo: Gizmag.com)
Tokai Challenger 2 - the cockpit of the solar-powered car almost makes an F1 car look roomy (Photo: Gizmag.com)
Celebrations get underway for the team from Tokai University (Photo: Gizmag.com)
Tokai Challenger 2 (Photo: Gizmag.com)
Tokai Challenger at the "finish of timing" earlier today (Photo: Gizmag.com)
Tokai University team leader Professor Hideki Kimura (Photo: Gizmag.com)
Tokai Challenger 2 on the final stretch of the World Solar Challenge (Photo: Gizmag.com)
World Solar Challenge official car head's to Adelaide (Photo: Gizmag.com)
Team Tokai has just reached the finish line in Adelaide, Australia, to become the winner of the 2011 World Solar Challenge. The victory makes it back-to-back wins for the Japanese team which took out the previous event in 2009.
All of the top three places are set to match the 2009 results when Nuon Solar Team from the Netherlands finished in second place, followed by the University of Michigan in third.
The Nuon Solar Car Team was hot on the heels of the Tokai vehicle throughout the final day this year, with Nuna6 running just 30 minutes behind - a very tight margin after four days on the road. Nuon is now expected to arrive at the finish line at around 10am tomorrow after running out of energy at Angle Vale, just north of Adelaide.
After starting in fifth position in Darwin, the Tokai team took the lead on the first day of the race and was never headed throughout the grueling 1800-odd mile journey, which this year posed extra challenges in the form of bushfires and road closures.
The Tokai Challenger 2 is a three-wheeler featuring carbon monocoque construction that harnesses solar energy using a six meter square array of silicon solar cells with a conversion efficiency of 22 percent. The vehicle has a claimed top speed of 160 km/h (99 mph). Energy capacity of the 21 kg (46.2 lb) lithium-ion battery is 5 kWh - which by way of comparison, is roughly the same amount of energy it takes to run an electric clothes dryer for one hour.
In 2009, Team Tokai completed the race in 29 hours and forty-nine minutes, averaging 100.54 km/h (62.47 mph). The average time set this year is expected to be very similar - we'll confirm the exact figure when official results are in. Either way, it's a remarkable achievement in a vehicle powered only by the Sun's rays.
The Tokai University vehicle reached the ceremonial finish line at approximately 2pm local time. The victory was a particularly emotional one for the Japanese team who were seeking to highlight the potential for solar power and the world-leading status of Japan's technologies in the aftermath of the Fukishima nuclear disaster.
We'll keep you posted on the official results as the remaining teams complete the Solar Challenge in coming days. In the meantime, Tokai University is set to celebrate its well earned win - check out the gallery for more photos.
Ed's note: this article was updated at 11:45 pm on 19 October as further information became available.
EnvironmentAustraliaWorld Solar ChallengeTokai University
ben October 20, 2011 09:36 PM
Soon there will have to be special closed roads because of the sheer speed of these things - to AVERAGE 100 km/h over a day and a night the daytime speed must be way over the road speed limit!
Gadgeteer October 23, 2011 12:13 PM
@ben,
I hope that\'s sarcasm about the writing in the article. The cars are only allowed to run during certain daylight hours. It\'s not 29 hours straight, but over the course of several days. Although the WSC site says this year\'s winning time was over 32 hours.


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