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The Pneuma Review
Journal of Ministry Resources and Theology for Pentecostal and Charismatic Ministries & Leaders
Living the Faith
Tag: "spirit"
Praying in the Spirit: Better Than I Was, Not Better Than You Are
The fifth chapter of the Praying in the Spirit Series. "You Pentecostals think you're better than anyone else, don't you?" The question startled the young Florida pastor attending his first ministerial association meeting. He stammered briefly and then with wisdom replied, "No, not at all. I am simply better than I was before." The question […]
March 10, 2000 | 1 comment | View Post
How to Receive the Baptism in the Holy Spirit
Many questions have been asked about the baptism in the Holy Spirit. Is it truly God's promise to every believer for today? If so, Is there any reason why all Christians should not receive it? What are the practical steps we need to take in order to receive this baptism? Can some things hinder […]
January 5, 2000 | 0 comments | View Post
Praying in the Spirit: Just What Is the Nature of the Prayer Language?
The fourth chapter of the Praying in the Spirit Series. I was in a meeting recently where a man began to offer a prophetic word, but before he finished a woman interrupted him with a message in tongues. It was obvious for several reasons that she was out of order: (1) She interrupted the speaker; […]
October 20, 1999 | 0 comments | View Post
Filled with the Holy Spirit
In this guest editorial, Pastor Mur shares his memories of being filled with the Holy Spirit and how he was reminded of this blessing of God while reading Robert Graves' article, "The Focus of the Charismatic Experience" that appeared in Summer 1999. Robert Graves' excellent article on "The Focus of the Charismatic Experience" […]
Praying in the Spirit: Focus of the Charismatic Experience: Tongues, the Holy Spirit, or Christ?
The third chapter of the Praying in the Spirit Series. The strongest criticisms leveled at the charismatic renewal seem to center on two theories: one, the experience is tongues-centered, and two, the experience is Spirit-centered. The two have in common, of course, the inference that the source and focus of the baptism and its attendant gifts […]
July 25, 1999 | 1 comment | View Post
Baptism in the Spirit: Is it Normal to Receive At or After Conversion?
Pastor Michael Peters looks at the Baptism with the Spirit in light of the whole salvation experience. Editorial Introduction This article is a chapter from Michael Peter's book In Defense of Charismatics. In Defense was written as a response to John MacArthur's book Charismatic Chaos and as a defense of charismatic beliefs and […]
July 15, 1999 | 0 comments | View Post
The Kingdom and the Spirit
In what way is the kingdom of God manifested in the time between the first and second coming of Jesus Christ? This question has been a prime preoccupation in discussions concerning the kingdom or reign of God. In this investigation we shall take a first step towards an answer by examining the nature of […]
June 25, 1999 | 0 comments | View Post
John Pester: Jesus Christ: Last Adam, Life-giving Spirit
John Pester, "Jesus Christ: Last Adam, Life-giving Spirit," Affirmation and Critique, Vol. 3, No. 4 (Oct. 1998). Affirmation and Critique is a quarterly which addresses theological subjects in a continuum. Through a variety of articles by numerous authors, the last seven issues have focused on the person and work of Christ in a weighty […]
May 23, 1999 | 0 comments | View Post
Praying in the Spirit: Some Marvelous Effects of Praying in the Spirit
The second chapter of the Praying in the Spirit Series. Most evangelicals believe that one always remembers the day he or she became a Christian. I remember the day very well. I was alone in a half‑completed apartment building off Interstate 1‑75 in Atlanta, Georgia. I was taking a lunch break from my summer job as […]
April 15, 1999 | 0 comments | View Post
Praying in the Spirit: What They're Saying Now: Some Non-Charismatics Reevaluate Tongues
The first chapter of the Praying in the Spirit Series. Bow-tied waiters glide across the plush red carpet. Sharply dressed gentlemen and elegantly appareled ladies devour crispy bacon, spicy sausage, and fluffy scrambled eggs. The smiling couple beside you probably has a college degree or two. Perhaps they are doctors, dentists, or lawyers. After the […]
March 10, 1999 | 0 comments | View Post
William De Arteaga: Quenching the Spirit
William De Arteaga, Quenching the Spirit: Discover the REAL Spirit behind the Charismatic Controversy (Orlando: Creation House, 1992, 1996), 358 pages, ISBN 9780884194323. William De Arteaga defines pharisaism as a religious attitude and heresy that so affirms the role of tradition that a new move of the Holy Spirit is often identified as demonic (p.335). […]
January 15, 1999 | 0 comments | View Post
The Place of the Holy Spirit in the Exegetical Process
I. Introduction In every generation there remains a perennial concern for all conscientious pastors, teachers and Christian workers. The question arises how can we, who have been entrusted with the ministry of expounding God's word make it clear and relevant while at the same time maintaining fidelity to the author's original intent? Furthermore how […]
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Donald Trump's Presidency and False Prophecy
John MacArthur's Strange Fire, reviewed by Craig S. Keener
Six Ways the Holy Spirit Will Communicate With You, by Charles Carrin
Rightly Understanding God's Word: Learning Context, Part 1, by Craig S. Keener
How to Pray Effectively for New Believers
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Agnes Sanford and Her Companions, reviewed by Jon Ruthven | Pentecostal Theology on Agnes Sanford: Apostle of Healing and First Theologian of the Charismatic Renewal, Part 1, by William L. De Arteaga
Clearing the Smoke, Fanning the Flames: An Interview with Michael Brown : The Pneuma Review on Are Pentecostals offering Strange Fire?
Jon Ruthven's Further reflections on Strangers to Fire, a response to John MacArthur : The Pneuma Review on Are Pentecostals offering Strange Fire?
Michael Brown's Authentic Fire, reviewed by Loren Sandford : The Pneuma Review on John MacArthur's Strange Fire, Reviewed by R. Loren Sandford
What I Like and Don't Like About the Modern Charismatic Movement : The Pneuma Review on The Colossian Heresy Revisited: Has the Prophetic Stream Lost Its Focus?
Amos Yong is Professor of Theology & Mission and director of the Center for Missiological Research at Fuller Theological Seminary, Pasadena. His graduate education includes degree...
Jelle Creemers: Theological Dialogue with Classical Pentecostals
Antipas L. Harris, D.Min. (Boston University), S.T.M. (Yale University Divinity School), M.Div. (Emory University), was appointed as the founding dean of the Urban Renewal Center
Symposium on the Holy Spirit and Theological Education 2019
Craig S. Keener, Ph.D. (Duke University), is F. M. and Ada Thompson Professor of Biblical Studies at Asbury Theological Seminary in Wilmore, Kentucky. He is author of many books<...
Gordon Fee: Jesus the Lord according to Paul the Apostle, reviewed by Craig S. Keener
William L. De Arteaga, Ph.D., is known internationally as a Christian historian and expert on revivals and the rebirth and renewal of the Christian healing movement. His major w...
The Global Christian Mission: The Maritime Global Expansion
Asian Theological Issues in Asian Journal of Pentecostal Studies: Vol 22 No 2
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East Africa's largest music festival cancelled!
Busara Promotions has reluctantly announced their decision to cancel the 2016 edition of Sauti za Busara due to a shortage of funding. Next year will therefore be the first time in 13 years that Zanzibar does not enjoy an international music festival in February.
Yusuf Mahmoud, CEO of Busara Promotions, announced today: "This decision was not taken lightly. Previously we had always announced festival dates a year in advance. But after closing the books on another highly successful festival in February 2015, once again we were back to square one, with no funds to start working on the next edition."
According to Mahmoud, the festival failed to raise the $200 000 target before July, when the next edition festival dates would have been announced. The fundraising period was then extended to Wednesday 19 August, but they only managed to raise $42 000, leaving the organisers with no option but to cancel the festival. Mahmoud said selling tickets for the festival "was never a problem" but ticket sales only account for 30% of the festival's costs.
Mahmoud noted that festivals such as Sauti za Busara invigorate young people's interest in local culture, give opportunities for artists and music professionals to meet and learn from each other, keep traditions alive, create employment for local people and promote models for responsible tourism that honour and respect local culture. "However, since 2004, we've had zero financial support from the government in Zanzibar, the United Republic of Tanzania or the East African Community. Despite tireless efforts, support from donors, embassies and commercial sponsors has reached an all-time low," he said, adding that Busara Promotions is an NGO and the festival is non-profit.
Busara Promotions is already exploring avenues to develop partnerships ahead the 2017 edition. "Some suggested we try crowd-funding. However, to truly be more sustainable, before the 2017 edition our priority will be to develop long-term partnerships with donors and sponsors who share our vision. If anyone reading this is interested to help keep Sauti za Busara alive, generating employment locally while shining the spotlight on our rich musical traditions and promoting cultural tourism for Zanzibar and Tanzania, please contact me at Busara Promotions," said Mahmoud.
Conservative estimates suggest that since 2004 Sauti za Busara has generated $70 million in revenue for the island, and the festival is widely regarded as one of the premier African music festivals in the world. "Sometimes it's necessary to take one step back, before continuing to move forwards," explained Mahmoud on the decision to cancel the 2016 edition. "The Busara Board and management shall be working hard over the coming months to ensure the festival resumes stronger than ever from 2017. Possibly this will mean moving location, or making it a biennial event. Certainly our priorities will be to keep the event accessible for the local population, whilst seeking to build longer-term partnerships with the public and private sectors."
While the festival takes a break, Busara Promotions will continue with its regular activities to promote African music, strengthen local knowledge and skills, and promote the regional music sector. Throughout the year, Busara ensures East African artists are invited to other international events and facilitates skills-building for local artists and festival crews, through exchanges and training in arts management, marketing, media and technical skills. This work, supported by the Royal Norwegian Embassy in Dar es Salaam, will fortunately not be affected by the decision to cancel Sauti za Busara 2016.


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Qualcomm Subsidiary Buys iSkoot, Which "Mobilizes Internet Services"
Qualcomm Innovation Center, a wholly owned subsidiary of Qualcomm, today announced it has acquired iSkoot Technologies, which specializes in the "mobilization" of Internet services such as social networks, consumer email and IM products.
Terms of the acquisition were not disclosed.
A good number of U.S. operators and device manufacturers offer iSkoot services, such as a free mobile app that aggregates access to various social networks, customizable news feeds and consumer email services within a single tool.
Check out iSkoot's Kalaida platform product pages for more information about its technology and commercial solutions (or read our earlier post on it). Essentially, it can provide basic phones with smartphone functionalities with minimal usage cost increase.
The Kalaida platform stems from iSkoot's acquision of Social.im (September 2008).
iSkoot Technologies is actually a newly-formed corporation that has recently received substantially all of the assets of iSkoot, a San Francisco-based service provider at the intersection of mobile and the internet that was founded back in 2005.
iSkoot will now function as a subsidiary of QuIC, Qualcomm's subsidiary focused on enabling and optimizing open source software with Qualcomm technologies.
According to the press release, the company will focus on continued support of its current customers, integrating its offerings with Qualcomm's products and developing open source data management contributions for mobile devices.
iSkoot had raised $32.2 million in venture capital from leading investors like Khosla Ventures and Charles River Ventures.
The company is led by Mark Jacobstein, who most recently served as the EVP at Loopt. Before joining Loopt, Jacobstein was the founding President for Digital Chocolate, one of the world's largest publishers of mobile games.
Rob Chandhok, president of Qualcomm Innovation Center, commented on the buy thusly:
"QuIC's acquisition of iSkoot provides us with a push data services platform, a social network aggregation solution and voice 2.0 services that dramatically strengthens our ability to continue providing the most effective mobile solutions for operators and device makers as they serve consumers worldwide."
Sounds like a good fit, although I'd be curious to know what QuIC spent on iSkoot, exactly.
Here's a video of AT&T's Social Net service, powered by iSkoot:
[youtube=http://www.youtube.com/watch?v=tVAwIbN8Wrk&w=640&h=400&fs=1&hl=en_US]

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Going Green is Good for the Planet and Insurance Rates!
Your first thought may be that the Green Movement and Insurance are not connected in any way. But I propose to you that the insurance rates you pay today and will pay in the future are greatly impacted by how well we take care of our planet.
You have probably heard of the concept of the "carbon footprint", i.e. the total set of GHG (greenhouse gas) emissions caused directly and indirectly by an individual, organization, event or product. The greener our daily habits, the less GHG's we produce, which in turn slows or reverses global warming. Hopefully, as people become more aware that they have a carbon footprint, they will make better decisions to control it.
Knowledge of how we are impacting our environment negatively is not just for tree-huggers and granola-eating hippies. Scientific study has proven these effects, and the mainstream is now embracing these concepts. It has been scientifically proven that as the planet heats up from all of these GHG's being emitted, this causes more violent weather. Hurricanes, drought and wildfires seem to be plaguing our continent more often and with more severity than ever before. Just this morning I turned on the news for about 5 minutes, and in that time, I learned about a Category-5 Hurricane bearing down on the Baja Peninsula and a major wildfire that is threatening the city of Los Angeles. A major contributor to the wildfire is drought. All of these disasters are caused by global warming, which is caused by our GHG emissions.
Of course, it is easy to connect natural disasters with major damage. And major damage means major insurance claims. And when an insurance company pays major claims, they will typically thereafter raise their rates dramatically across the country to make up for their losses, start adding exclusions or changing their coverage for certain risks, or simply go out of business and leave their clients in a lurch.
The only way to avoid these events or at least lessen the risk is for each person and organization to embrace the ideas that it all starts with us. We choose whether our future and our children's future is bleak or full of hope and promise. Individually we must each decide whether to keep doing things the same, or to make a change for the better. We must pressure our corporations and businesses to act ecologically responsibly in their production of goods and services. We must pressure our politicians to create laws and ordinances that enforce good ecology practices both from businesses and individuals.
Some insurance carriers are now offering a discount if you have Solar Panels on your home.
Some auto insurance carriers are offering pay-as-you-drive insurance, giving discounts for those who drive less than average drivers.
Going paperless by allowing your insurance company to send you all documents and billing by email can also result in a discount. Kari Fortin with Centurion Mortgage is just one example of a client who is taking advantage of this green discount.
In commercial insurance, there are a growing number of insurance carriers that offer insurance specifically for a "Green Building" that covers a range of green building features, including credits and discounts related to recycled materials, energy-efficient products, green roofs and business interruption.
Travelers Insurance, one of the carriers that Judge Fite Insurance represents, is providing eco-friendly coverage to small businesses that enables them to repair, rebuild, replace or upgrade to green building elements under it's "Master Pac Green Endorsement".
A great source for information about going green for businesses is www.GreenBiz.com.
For more information about insurance for you home, investments, vehicles, or business, contact Judge Fite Insurance Agency today atinsurance@judgefite.com or 214-446-2572.


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Next-generation sequencing in familial breast cancer patients from Lebanon
Nadine Jalkh1,
Eliane Chouery1,
Zahraa Haidar1,
Christina Khater2,
David Atallah3,
Hamad Ali4,5,
Makia J. Marafie6,
Mohamed R. Al-Mulla7,
Fahd Al-Mulla5,8 &
Andre Megarbane9
BMC Medical Genomics volume 10, Article number: 8 (2017) Cite this article
Familial breast cancer (BC) represents 5 to 10% of all BC cases. Mutations in two high susceptibility BRCA1 and BRCA2 genes explain 16–40% of familial BC, while other high, moderate and low susceptibility genes explain up to 20% more of BC families. The Lebanese reported prevalence of BRCA1 and BRCA2 deleterious mutations (5.6% and 12.5%) were lower than those reported in the literature.
In the presented study, 45 Lebanese patients with a reported family history of BC were tested using Whole Exome Sequencing (WES) technique followed by Sanger sequencing validation.
Nineteen pathogenic mutations were identified in this study. These 19 mutations were found in 13 different genes such as: ABCC12, APC, ATM, BRCA1, BRCA2, CDH1, ERCC6, MSH2, POLH, PRF1, SLX4, STK11 and TP53.
In this first application of WES on BC in Lebanon, we detected six BRCA1 and BRCA2 deleterious mutations in seven patients, with a total prevalence of 15.5%, a figure that is lower than those reported in the Western literature. The p.C44F mutation in the BRCA1 gene appeared twice in this study, suggesting a founder effect. Importantly, the overall mutation prevalence was equal to 40%, justifying the urgent need to deploy WES for the identification of genetic variants responsible for familial BC in the Lebanese population.
Breast cancer (BC) is the most common cancer in women, accounting for around 25% of all new cases of cancer [1]. Most BC cases are sporadic, while 5 to 10% of all BC cases are inherited and cluster in families [1]. While mutations in BRCA1 and BRCA2 genes explain 16–40% of all familial BC cases [1–3], other genes have also been found to increase BC susceptibility, which highlights the polygenic nature of many BC cases [4]. Some of these genes including CDH1, TP53, PTEN and STK11, although less frequently altered compared to the BRCA1/2 genes, they have been linked to high-penetrance autosomal dominant BC [5–7]. Moderate penetrance genes are implicated in around 5% of familial BC. These genes include the Fanconi anemia pathway genes: FANCA, PALB2, BRIP1, RAD51C and XRCC2 [8–10] and non-Fanconi anemia genes: ATM, CHEK2, NBN, RAD50, RAD51B, and RAD51D [11–15].
In Lebanon, BC is the most common cancer type in females and it constitutes one-third of all reported cancer cases. BC incidence rates are expected to reach 137 per 100,000 by 2018 [16]. Yet, to date, only two studies have investigated the role of BRCA1 and BRCA2 mutations in the Lebanese population. These studies reported varied prevalence of pathogenic BRCA mutations ranging between 5.6 to 12.5% in BC cases [17, 18]. The reported prevalences of both BRCA1 and BRCA2 deleterious mutations were lower than those reported for the Western populations, which suggest the involvement of other genes in the pathogenesis of BC cases [19]. The reported low prevalence does not support the hypothesis that BRCA1 and BRCA2 mutations alone are responsible for the majority of the observed Lebanese women with early-onset BC. This finding could well explain the fact that BC is a disease with a high level of genetic heterogeneity and that monogenic and polygenic models of inheritance may exist.
Since the completion of the human genome project, massive leaps have reshaped the field of clinical genomics. The development of Next-generation sequencing (NGS) platforms allowed a more robust, fast and accurate analysis of diseases and syndromes with polygenic nature. NGS platforms including WES are believed to enhance and improve diagnosis and therapy development of many diseases including BC [20–23].
In the presented study, we utilized WES to investigate germline genetic variations in 45 Lebanese cases diagnosed with familial BC and unknown BRCA1 or BRCA2 status. We found several rare variants that can potentially explain BC susceptibility in the analyzed cases.
From 2012 to 2015, 45 unrelated patients with inherited BC were selected to undergo DNA testing. They were referred from a wide variety of settings from all over the country, ranging from private physicians' clinics to major academic medical centers because of hereditary BC. The patients fulfilled a personal history of invasive BC and at least one of the following criteria: A) diagnosis at age ≤ 40 years, B) BC at any age at onset with at least 2 first- and/or second-degree relatives, C) BC < 50 years in a first- or second-degree relative, D) ovarian cancer in at least 2 first- and/or second-degree relatives, E) breast and ovarian cancer in at least 2 first- and/or second-degree relatives, F) both breast and ovarian cancer in a single first- or second-degree relative.
Approval to conduct the study was obtained from the Ethics Committee of Saint-Joseph University-Lebanon. After an informed consent was signed and all ethical requirements were fulfilled, a 10 ml of peripheral blood was isolated from each individual enrolled and the DNA was extracted using the salting out methods [24]. All patients signed the informed consent and agreed to share their variant data.
Exon capture and sequencing: Samples were prepared for whole Exome sequencing and enriched according to the manufacturer's standard protocol. The concentration of each library was determined using Agilent's QPCR NGS Library Quantification Kit (G4880A). Samples were pooled prior to sequencing with each sample at a final concentration of 10nM. Sequencing was performed on the Illumina HiSeq2000 platform using TruSeq v3 chemistry.
Mapping and alignment: Reads files (FASTQ) were generated from the sequencing platform via the manufacturer's proprietary software. Reads were aligned to the hg19/b37 reference genome using the Burrows-Wheeler Aligner (BWA) package v0.6.1 [25]. Local realignment of the mapped reads around potential insertion/deletion (Indel) sites was carried out with the Genome Analysis Tool Kit (GATK) v1.6 [26]. Duplicate reads were marked using Picard v1.62. Additional BAM file manipulations were performed with Samtools 0.1.18 [27]. Base quality (Phred scale) scores were recalibrated using GATK's covariance recalibration. SNP and Indel variants called using the GATK Unified Genotyper for each sample [28]. SNP novelty is determined against dbSNP. A list of 134 genes known to be associated with hereditary BC and other cancers were studied (Additional file 1).
Variants evaluation
Variants obtained were reported using five categories according to the Human Genome Mutation Database (HGMD Professional) [29]. These categories are listed in Table 1.
Table 1 Variants reported in five categories according to the HGMD Professional
The first variant category consists of alleles labeled as disease causing mutations (DM) in HGMD Professional. These alleles must be rare: <1% allele frequency in 6,500 exomes from the National Heart, Lung, and Blood Institute (NHLBI) Exome Sequencing Project ("Exome Variant Server" 2015) and the 1,000 Genomes Project Genomes [30].
The BRCA gene variants identified were checked for pathogenicity in 4 databases: Breast Cancer Information Core (BIC) [31], Leiden Open Variation Database (LOVD) [32], the Catalogue of Somatic Mutations in Cancer database (COSMIC) [33] and BRCA Exchange website (http://brcaexchange.org) providing data from the ENIGMA consortium [34].
Variants confirmation
Sanger's sequencing was utilized to confirm the relevant variants identified by WES and to study the segregation of these variants with the disease phenotype in members of families included in the study. PCR reactions were run in final volumes of 50 μl containing 100 ng DNA, 0.25 mM dNTPs, 100 ng of each primer and 0.02 unit of Taq polymerase (Invitrogen Life Technologies, Carlsbad, CA, USA). PCR was performed in an ABI9700 thermocycler (Applied Biosystems, Foster City, CA) with initial denaturation at 94 °C for 5 min, followed by 35 cycles of 95 °C for 30s, specific annealing temperature for 30s, 72 °C for 30s. Primer sequences are available on request as well as annealing temperatures of each exon. PCR products were purified using the illustraTM GFX PCR DNA and Gel Band Purification Kit (GE Healthcare, Buckinghamshire, UK). Both strands of the products were sequenced using the BigDyeW Terminator v1.1 Cycle Sequencing Kit (Applied Biosystems, Foster City, CA) under standard conditions. The labeled products were subjected to electrophoresis on an ABI3130 and ABI3500 Genetic Analyzer sequencing system (Applied Biosystems, Foster City, CA, USA). Electropherograms were analyzed using Sequence Analysis Software v5.2 (Applied Biosystems, Foster City, CA, USA) and compared to reference sequences using ChromasPro v1.7.6.1 (Technelysium, Queensland, Australia).
Patient characteristics and sequencing statistics
The mean age at diagnosis of BC for the 45 patients was 44 years (range 29–79). Sixteen patients provided us with their histopathological results. Seven BC were estrogen-receptor (ER) and progesterone-receptor (PR) positive, 5 patients had negative ER and PR disease and 2 patients had negative ER and positive PR disease. Two patients had triple negative disease from which one patient (Family 30) carried p.C44F mutation in BRCA1 (Fig. 1).
Pedigrees of the families presenting DM mutations. Filled squares (males) and circles (females) indicate the affected individuals. Probands are marked with arrows. DM mutations are bolded
We obtained an average of 44 million reads per sample, with a mean coverage of 94% at a mean X coverage of 20X.
WES analysis
Within this cohort, a total of 126 variants were detected by WES and these are listed in Table 2. In 7 of the 45 patients, not listed in Table 2, no variants in cancer predisposing genes (Additional file 1) were identified.
Table 2 Mutations in BC associated genes detected by NGS in a series of 45 Lebanese patients
We were able to detect 19 HGMD DM variations of which 9 are specifically associated with breast cancer (Table 2). The distribution of the remaining variants in the HGMD categories was: 11 DM?, 11 DP, 1 FP, and 9 DFP. In addition, 75 novel variations were detected in this study (Table 2).
Six BRCA1 and BRCA2 DM mutations were detected in 5 and 2 patients, respectively in a total prevalence of 15.5% (Table 2).
Nine truncating mutations were detected in 9 different patients (Table 2). Three of these mutations were DM in HGMD: The first woman carried p.R1443* in BRCA1, the second one carried p.V220I* in BRCA2 and the third one carried p.G164X in ABCC12 (Table 2). The six remaining truncating mutations were not found in HGMD: p.Q613X in SLX4, p.R170X in ERCC3, p.Q117X in EZH2, p.P742fs in NSD1, p.357_364del in BARD1 and p.L1697fs in BRCA1 (Table 2).
Three DM mutations were found, each one, in 2 different patients: p.C44F in BRCA1 (Families 13 and 30), p.P349A in MSH2 (Families 7 and 24) and p.G141W in SLX4 (Fig. 1 and Table 2).
In some families where different variants were found, in order to consider, which variant is pathogenic, we analyzed the co-segregation of the variations found with the cancer phenotype within 3 families 12, 13, and 32 (Figs. 1 and 2).
Pedigree of one family segregated for BRCA2 p.T1354M and CDH1 p.M1I variants. Filled squares (males) and circles (females) indicate the affected individuals. + sign indicates the presence of the variant and – sign the absence of the variant in tested individuals
Two members of family 12 were diagnosed with BC, their mother and maternal uncle were diagnosed with primary lung cancer and bone cancer, respectively. The nonsmoking mother was affected at the age of 63 but the age of the maternal uncle at diagnostic was not accessible. WES, in proband 12/B35 diagnosed with BC at the age of 42, identified 2 variants including one DM? p.I94L in RAD50, according to HGMD Professional database, and one novel variation p.G191R in ARL11 (data not shown). Prediction tool Polyphen2 indicated that both changes are benign and SIFT prediction tool indicated that p.I94L in RAD50 is tolerated and that p.G191R in ARL11 is damaging. Only p.I94L in RAD50 segregated in the affected sisters, diagnosed with BC at the age of 48, but it was also found in their third youngest 51 years old unaffected sister.
Three members of Family 13 were diagnosed with BC. WES identified 3 DM according to HGMD Professional database, including p.C44F in BRCA1, p.G141W in SLX4 and p.S404F in STK11 (Table 2). Leiden Open Variation Database indicated that p.C44F in BRCA1 affects protein function and it segregated with the disease (Table 3) (Fig. 1).
Table 3 BRCA variations found and their evaluations in BRCA databases
Six members of family 32 were diagnosed with BC (Fig. 2). Members III-3, III-4 and III-6 were diagnosed with BC at the age of 56, 48 and 50, respectively. WES in proband III-4 identified 2 relevant variants including p.M1I in CDH1 and p.T1354M in BRCA2. Prediction tool SIFT indicated that both changes are damaging and are DM according to HGMD Professional database (Table 2 and Fig. 2). The analysis of this family showed that these variations were carried by affected and siblings that are not affected to date (Fig. 2). However, they were advised to join our screening program.
We have noted that the most frequently altered genes involved in our familial cases are DNA repair genes (Fig. 3a) and that some variants were recurrent in our cohort: p.W149X in ARL11, p.S836S in RET, p.A126T in RAD51C, p.T241M in XRCC3, p.G998E in PALB2 and c.673-36G > C in TP53 (Table 2 and Fig. 3b). In four cases, like the 4 families shown in Fig. 1, individuals appear to co-inherit multiple cancer causing or predisposing gene mutations. Unlike, the old strategy where one stops the investigation once a pathogenic mutation was identified, NGS gives us the capability of collating all known mutations/variants in a sample, which may permit a more comprehensive understanding of the polygenic landscape model of cancer. An important question to be answered is: Does an individual in Family 13 harboring all three DM mutation have different penetrance, genotype to phenotype correlation, type or age of onset of cancer than a sibling with only one DM variant? This critical question can only be answered when we start to combine all germline variant data of cancer patients and their comprehensive phenotypes from around the world in well-curated databases.
Frequencies of all variants in breast cancer predisposing genes from our 45 patients' cohort (a) and the details of the most frequent variants shown in (b)
We identified, in 45 patients with familial BC, 19 pathogenic mutations that are DM mutations according to the HGMD Professional database (Table 2). These 19 mutations were found in 13 different genes including ABCC12, APC, ATM, BRCA1, BRCA2, CDH1, ERCC6, MSH2, POLH, PRF1, SLX4, STK11, and TP53. Six mutations were found in BRCA1 and BRCA2 presenting a lower prevalence (15.5%) of deleterious BRCA mutations compared to the published literature [21–23].
In the Lebanese population, p.C44F mutation in the BRCA1 gene was found twice in this study and 5 times in previous studies [17, 18] in a total of 7 from 367 cases studied (1.9%). In fact, 2 of 9 patients carried a deleterious BRCA mutation in a cohort of 72 patients and 3 of 14 patients carried a deleterious BRCA mutation in a cohort of 250 patients. Our findings suggest it is the most recurrent mutation in the Lebanese population.
In families 23 and 35, we identified the truncating mutation p.357_364del in BARD1 (Table 2). A previous study, on this variation, showed the absence of co-segregation with the disease and it was considered as neutral polymorphisms [35]. We have observed this variant in our population and breast cancer patients and it is recommended that a more thorough and functional examination of this variant be conducted in the future.
In families 12, 13 and 32, we identified 7 variants in ARL11, BRCA1, BRCA2, CDH1, RAD50, SLX4, and STK11. The association of which variation towards increasing predisposition to BC remains unknown. Therefore, we analyzed the segregation of these variations and BC within the families. In family 13, only p.C44F in BRCA1 segregated with BC in the family. In family 12, p.I94L in RAD50 (a DM? mutation) was found in affected and healthy sisters and could therefore not lead to a conclusion regarding predisposition to BC. In family 32, p.M1I in CDH1 and p.T1354M in BRCA2 are implicated in gastric cancer and BC respectively and knowing that the family presented with only BC, two hypothesis can be formulated. First, III-6 can be considered as phenocopy and second healthy, till now, sisters III-5, III-7 and III-9 are at high risk (Fig. 2). In fact, in high-risk families, women testing negative for the familial BRCA mutation have an increased risk of BC and should be considered for continued surveillance [36]. Interestingly, two members of this family, III-4 and III-6 presented with invasive lobular breast cancer (Fig. 2). The association between CDH1 gene mutation and lobular cancer has been well established previously [37], and it is not unrealistic to suggest that this CDH1 variant may be the cause of lobular breast cancer in this family.
The pathogenic status of the majority of novel substitutions found and the 6 variations considered as DM? according to HGMD professional, remains problematic (Table 2). In fact, HGMD professional reports DM? as likely pathological mutation reported to be disease causing in the corresponding report, but the author has indicated that there may be some degree of doubt, or subsequent evidence has come to light in the literature, calling the deleterious nature of the variant into question [29]. Further studies are needed to define the pathogenic status of the novel substitutions and the DM? variations that have been found in our cohort of patients with BC. These future studies have to be analyzed in a larger number of affected families and control population samples.
NGS and traditional sequencing methods are not proficient in detecting BRCA genomic rearrangements including large deletions or duplications. Deletion and duplication genomic rearrangements vary significantly among countries and within ethnic groups [38]. We admit, therefore, that our reported BRCA mutation prevalence is underestimated.
Among the DM mutations found, several were associated with syndromes (Peutz-Jeghers), different cancer types (renal cell carcinoma, gastric cancer) and with diseases (Xeroderma pigmentosa, ataxia telangiectasia) (Table 2). Clinically, none of the symptoms found in these diseases were manifested in the different studied families except for family 24. In this family, proband 24/B49 carried the mutation p.R1443* in BRCA1 and two MSH2 variants (Fig. 1). Her mother had ovarian cancer and her sister uterine cancer, both are deceased and could not consequently be tested for these variants. MSH2 mutation is reported in families with endometrial cancer (Lynch syndrome) and breast cancer from Kuwait [39].
This is the first application of NGS on BC in Lebanon. In this study, we showed that the prevalence of deleterious BRCA mutations (15.5%) is lower than expected [17, 18] and that the overall mutation prevalence is equal to 40%, justifying the urgent need for the adoption of high-throughput NGS technologies to identify genes responsible for familial BC in the Lebanese population. Indeed, additional to BRCA mutations, highly penetrant mutations in genes associated with various hereditary cancer syndromes, such as CDH1, TP53, MSH2, ATM and POLH were found in the Lebanese population. Finally, we cannot rule out that some of these families shift a putative explanation towards a polygenic model where moderate and low penetrance alleles, acting together, may play a predominant role [20, 40, 41]. Our findings support the eligibility of performing genetic testing by massively parallel sequencing on Lebanese familial BC cases. Moreover, we would like to use this technology for tumor genome sequencing, in order to identify somatic alterations, which would be a valuable guidance towards individualized cancer therapy of Lebanese patients with BC. However, it is worthy of note that our study reports a small number of variants that are clinically actionable. Given the high rate of novel variants identified in BRCA1/2 and other breast cancer-associated genes, the clinical usefulness of the data is currently limited. Unless larger and rigorous studies are committed in this area of the world to correctly classify variants identified here or in other studies, the diagnosis and treatment of breast cancer will remain suboptimal.
This is the first study that utilized NGS technology to study genetic variants in 45 patients with familial breast cancer from Lebanon. Our deleterious mutation prevalence was 40% with only 15.5% accounted for by the BRCA1 and BRCA2 genes. This data should encourage a different strategy for familial breast cancer genetic screening in Lebanon, one that is based on WES rather than the initial screening of BRCA1/2 genes. We report here novel and rare variants in breast cancer predisposing genes, which will be valuable to researchers and clinicians around the world for variants' classification and patients' care in general.
Breast cancer information core
BWA:
Burrows-wheeler aligner
COSMIC:
Catalog of somatic mutations in cancer database
DFP:
Disease-associated polymorphism
Disease-causing mutations
DM?:
DP:
FP:
In vitro/laboratory or in vivo functional polymorphism
GATK:
Genome analysis tool kit
HGMD Professional:
Human genome mutation database
LOVD:
Leiden open variation database
NHLBI:
WES:
Whole exome sequencing.
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Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 2015;43(Database issue):D805–811.
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Marafie MJ, Al-Awadi S, Al-Mosawi F, Elshafey A, Al-Ali W, Al-Mulla F. Impact of 226C > T MSH2 gene mutation on cancer phenotypes in two HNPCC-associated highly-consanguineous families from Kuwait: emphasis on premarital genetic testing. Fam Cancer. 2009;8(4):289–98.
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We would like to thank all the patients and their family members who contributed their samples and information for this study.
This work was supported by a grant from the Kuwait Foundation for the Advancement of Sciences (KFAS No. 2011-1302-06) given to Prof. Fahd Al-Mulla and by grants from the Saint Joseph University and the Mohamad Cheaib Foundation.
Data generated or analyzed during this study are included in this published article and its Additional file. The link to the compiled data will be shared on our website http://www.al-mulla.org, which will be made available once it is connected to international databases in the near future. Meanwhile, data supporting the manuscript can be requested from the any of the two corresponding authors.
NJ, FM, AM: drafted the manuscript. NJ, EC, ZH, HA, FM, MRM: carried out the molecular genetic studies and participated in the sequence alignment. CK, DA, MJM: acquisition of data. FM, HA, MRM, NJ: performed statistical analysis and interpretation of data. FM, AM conceived of the study, participated in the design of the study, and in its design and coordination. All authors read and approved the final manuscript.
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
All patients signed the informed consent during the counseling sessions and agreed to share their variant data in a reputable scientific journal.
Approval to conduct the study was obtained from the Ethics Committee of Saint-Joseph University-Lebanon. Written informed consent was obtained at the time of enrollment for genetic sample collection.
Unité de Génétique Médicale, Pôle Technologie Santé, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Nadine Jalkh
, Eliane Chouery
& Zahraa Haidar
Trad Hospital, Beirut, Lebanon
Christina Khater
Department of Gynecology and Obstetrics, Hôtel-Dieu de France University Hospital, Saint Joseph University, Beirut, Lebanon
David Atallah
Department of Medical Laboratory Sciences (MLS), Faculty of Allied Health Sciences, Health Sciences Center (HSC), Kuwait University, Safat, Kuwait
Dasman Diabetes Institute (DDI), P.O Box 1180, Dasman, 15462, Kuwait
& Fahd Al-Mulla
Kuwait Medical Genetics Center, Maternity Hospital, Safat, Kuwait
Makia J. Marafie
Department of Computing Sciences and Engineering, Kuwait University, P.O. Box 5969, Safat, 13060, Kuwait
Mohamed R. Al-Mulla
Health Sciences Center, Faculty of Medicine, Department of Pathology, Kuwait University, P.O.Box 24923, Safat, 13110, Kuwait
Fahd Al-Mulla
Institut Jerome Lejeune, Paris, France
Andre Megarbane
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Correspondence to Fahd Al-Mulla or Andre Megarbane.
Cancer genes explored in this study. (DOCX 11 kb)
Jalkh, N., Chouery, E., Haidar, Z. et al. Next-generation sequencing in familial breast cancer patients from Lebanon. BMC Med Genomics 10, 8 (2017) doi:10.1186/s12920-017-0244-7


BACK TO THE DUNGEON!: Class and Race Updates for back to the Dungeon RPG!
Class and Race Updates for back to the Dungeon RPG!
Here is the new format for Classes and Races for back to the Dungeon RPG.
Still a bit of meat bit very streamlined.
I present the cleaned up Rogue and Dwarf.
ability to manipulate others by their sheer personality.
will gather together and form Thievery Guilds.
climb sheer surfaces that no other class can climb.
activities better than any other class.
text if he is literate.
varies from area to area.
hidden things and to notice traps and tricks.
their Charisma to charm and convince others.
appearance they are very dangerous opponents in war.
gold and gems for which they love so dearly.
can see in the dark 60'.
and will attack them on sight.
• GIANTFIGHTER: Dwarves take half damage from giants.
no other class can climb.
and may fling equal to his Dexterity bonus per round.
time in cramp hidden places to stalk their prey.
magic scrolls as well as ancient text if he is literate.
They have knowledge of various poisons and their effects.
shadow someone in a crowd.
precious gold and gems for which they love so dearly.
and new construction while underground.
Dwarves can push a victim back five feet on a critical.
they concentrate in a large area just not exactly where!
to tell what type by a successful Wis roll.
Dwarves do double damage against creatures made of stone.


text:
DÉCOUVRIRBIBLIOTHÈQUE
Fishing World February 2020
Fishing World is Australia's longest established fishing magazine and has been serving the needs of anglers for more than 46 years. Fisho is Australia's premier fishing magazine and has become known as the "sport fishing bible". Voted Best National Magazine 2014 Australian Fishing Trade Association.
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no time to fish? no worries.
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flattie stocking trial a first for nsw!
IN a first for NSW, more than 1000 juvenile dusky flathead have been stocked into Lake Macquarie on the Central Coast as part of a research project to enhance populations of this highly popular sportfish. DPI has been working on breeding technology for duskies over the past year. These sort of pilot-scale releases, where relatively small numbers of fish are released and studied intensively, allow us to test and refine stocking strategies. This work will hopefully enable large scale stocking of dusky flathead in key estuaries along the NSW coast. The Port Stephens Fisheries Institute has now successfully reared juvenile dusky flathead, and released 1200 fish measuring up to 15cm in the southern areas of Lake Macquarie, a Recreational Fishing Haven on the Central Coast north of Sydney. A visible fluorescent tag…
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THESE FOOLISH THINGS
by ADRIANA SASSOON on Thursday, June 5, 2014 Thursday, June 5, 2014
A young actress seeks to follow in her famous mother's footsteps.
Zoe Tapper
Angelica Huston
These Foolish Things is a 2006 film based on Noel Langley's novel There's a Porpoise Close Behind Us and directed by Julia Taylor-Stanley.
It stars Zoe Tapper, David Leon, Lauren Bacall, Anjelica Huston and Julia McKenzie. The drama was largely filmed on location in Bristol, Cheltenham and surrounding areas of Gloucestershire.
Ella Fitzgerald songs
VIDAL SASSOON THE MOVIE
by ADRIANA SASSOON on Sunday, December 6, 2009 Wednesday, March 21, 2012
Sassoon was born to Jewish parents in London. His father was from Salonica (Thessaloniki in Greece), and his mother, whose family was originally from Kiev, was born in London. Although too young to serve in the Second World War, Sassoon became a member of the 43 Group, a Jewish veterans' militia organisation that broke up Fascist meetings in East London after the end of the war. In 1948 he joined the Israeli Defence Forces to fight in the 1948 Arab-Israeli War.
http://wp.me/pb3nG-134
Influence in hairstyling
Sassoon's works include the geometric, the wash-and-wear perm, and the "Nancy Kwan." They were all modern and low-maintenance. The hairstyles created by Sassoon relied on dark, straight, and shiny hair cut into geometric yet organic shapes. In 1963, Sassoon created a short, angular hairstyle cut on a horizontal plane that was the recreation of the classic "bob cut." His geometric haircuts seemed to be severely cut, but were entirely lacquer–free, relying on the natural shine of the hair for effect. Sassoon is a father of modernist style and has also been a key force in the commercial direction of hair styling, turning its craft in to a multi-million dollar industry.
WWW.VIDALSASSOONTHEMOVIE.COM
Boston's Fall Film Festivals
by ADRIANA SASSOON on Thursday, October 2, 2008 Wednesday, March 21, 2012
© 2008 Microsoft Corporation © 2008 NAVTEQ © AND
Museum of Fine Arts
465 Huntington Ave.
Maria Olia
With a population of graduate students and intellectuals, Boston supports the screening of many thought-provoking art films throughout the city.
One of the best movie houses in town that regularly screens independent and international film is the Remis Auditorium at the Museum of Fine Arts. for those watching their entertainment budge note that tickets are a relative bargain too- general admission for all screenings is just $10.
This fall, several international film festivals are scheduled. The Boston Palestine Film Festival is scheduled for October 4-October 12. This year's highlights include the screening of 10 films, many of which address the issues of the Palestinian diaspora. There will be a visit by filmmaker Michel Khleifi on October 11 and a concert by acclaimed international musician Simon Shaheen on October 10th.
Although the exact film and event schedules have not been finalized, the Boston Jewish Film Festival runs from November 5-Novenmber 16 and will screen recent film festival features and documentaries with Jewish themes. And finally, the Boston Festival of Films from Iran is planned for November 7-28 and always has an impressive line-up of internationally awarded art films made in Iran which offer an interesting perspective of modern-day Iranian society.


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text:
FINRA Fines Raymond James $17M Anti-Money Laundering Failures
WASHINGTON — The Financial Industry Regulatory Authority (FINRA) announced today that it has fined Raymond James & Associates, Inc. (RJA) and Raymond James Financial Services, Inc. (RJFS), a total of $17 million for widespread failures related to the firms' anti-money laundering (AML) programs. RJA was fined $8 million and RJFS was fined $9 million for failing to establish and implement adequate AML procedures, which resulted in the firms' failure to properly prevent or detect, investigate, and report suspicious activity for several years. RJA's former AML Compliance Officer, Linda L. Busby, was also fined $25,000 and suspended for three months.
RJA and RJFS' significant growth between 2006 and 2014 was not matched by commensurate growth in their AML compliance systems and processes. This left RJA and Busby, as RJA's AML Compliance Officer from 2002 to February 2013, and RJFS unable to establish AML programs tailored to each firm's business, and forced them instead to rely upon a patchwork of written procedures and systems across different departments to detect suspicious activity. The end result was that certain "red flags" of potentially suspicious activity went undetected or inadequately investigated. These failures are particularly concerning given that RJFS was sanctioned in 2012 for inadequate AML procedures and, as part of that settlement, had agreed to review its program and procedures, and certify that they were reasonably designed to achieve compliance.
Brad Bennett, FINRA's Executive Vice President and Chief of Enforcement, said, "Raymond James had significant systemic AML failures over an extended period of time, made even more egregious by the fact the firm was previously sanctioned in this area. The monitoring for suspicious transactions is an essential part of protecting our financial system and firms must allocate adequate resources to their AML compliance efforts. This case demonstrates that when there are broad-based failures within specific areas of responsibility, we will seek individual liability where appropriate."
During its investigation, FINRA found that the firms failed to conduct required due diligence and periodic risk reviews for foreign financial institutions, and that Busby failed to ensure that RJA's reviews were conducted. RJFS also failed to establish and maintain an adequate Customer Identification Program.
In concluding these settlements, Raymond James & Associates, Inc., Raymond James Financial Services, Inc., and Busby neither admitted nor denied the charges, but consented to the entry of FINRA's findings.
Investors can obtain more information about, and the disciplinary record of, any FINRA-registered broker or brokerage firm by using FINRA's BrokerCheck. FINRA makes BrokerCheck available at no charge. In 2015, members of the public used this service to conduct 71 million reviews of broker or firm records. Investors can access BrokerCheck at www.finra.org/brokercheck or by calling (800) 289-9999. Investors may find copies of this disciplinary action as well as other disciplinary documents in FINRA's Disciplinary Actions Online database. Investors can also call FINRA's Securities Helpline for Seniors at (844) 57-HELPS for assistance or to raise concerns about issues they have with their brokerage accounts and investments.
FINRA, the Financial Industry Regulatory Authority, is the largest independent regulator for all securities firms doing business in the United States. FINRA is dedicated to investor protection and market integrity through effective and efficient regulation and complementary compliance and technology-based services. FINRA touches virtually every aspect of the securities business – from registering and educating all industry participants to examining securities firms, writing rules, enforcing those rules and the federal securities laws, and informing and educating the investing public. In addition, FINRA provides surveillance and other regulatory services for equities and options markets, as well as trade reporting and other industry utilities. FINRA also administers the largest dispute resolution forum for investors and firms. For more information, please visit www.finra.org.
SEC Fines J.P. Morgan $125m for Failure to Keep Records
Employees often communicated about securities business matters on personal devices.
FTX US Selects Eventus for Surveillance and Risk Monitoring
FTX US Derivatives and FTX US plan to implement cross-market crypto surveillance.
FTX US Adds TRM Labs for Compliance
The crypto exchange has completed its acquisition of regulated futures exchange LedgerX.
CFTC Fines UBS for Failure to Keep Audio Recordings
Some recordings need to be retained for one year.


I wrote a while ago about DynamoDB in the trenches, but that was in 2012 and now 2015 is nigh.
The real pain point of DynamoDB is that everything is a hash key. It's not sorted, at all. Ever.
A local secondary index isn't the answer; it's a generalization of range keys, and as such, is still subordinate to the hash key of the table. An LSI does not cover items with different hash keys.
A global secondary index isn't helpful in this regard, either. It is essentially building and maintaining a second table for you, where its hash key is the attribute the index is on, and then it stores the key of the target element (and optionally, any other attributes from that element) from the 'parent' table. But as a hash key, it doesn't support ordering... The only thing that can be done with the index is a Scan operation.
DynamoDB still offers nothing else.
Some ideas that would seem, on their surface, to be perfect for DynamoDB actually don't work out well, because there's no efficient query for ordered metadata. Most frequently, this bites me for data that expires, like sessions. Sessions! The use case that's so blindingly obvious, the PHP SDK includes a DynamoDB session handler.
We store SES message data in there to correlate bounces with the responsible party. We have a nightly job that expires the old junk, and just live with it sucking up a ton of read capacity when it has to do that. On the bright side, unlike sessions, the website won't grind to a halt (or log people out erroneously) if the table gets wedged.
I'd like to put some rarely-changing configuration data in there (it's in SimpleDB and cached in memcache because SimpleDB had erratic query performance), but I wouldn't be able to efficiently search over it when I wanted to look up an entry for editing in the admin interface. And really, I still want to put that in LDAP or something.
Honestly, if all I get with DynamoDB is a blob of stuff and a hash key, why not just store it as a file in S3? How is DynamoDB even a database if it doesn't actually do anything with the data, and doesn't let you have any metadata? Am I the crazy one, or is that the NoSQL crowd?
Related: Tim Gross on Falling In And Out Of Love with DynamoDB.


An artist's rendering of a new video scoreboard that will be installed at center ice in the John J. MacInnes Student Ice Arena.
At its regular meeting today, Michigan Technological University's Board of Trustees approved purchase of a new video scoreboard for the John J. MacInnes Student Ice Arena. All funding for the scoreboard and its installation comes from gifts from donors.
The four-sided Mitsubishi Diamond Vision video board will hang over the center of the ice. Each side is 14 feet wide by 14.5 feet high and includes a 14 by 8 foot video screen. The total weight of the new scoreboard will be more than 12,000 pounds.
The Board also approved a new concentration in business analytics. It will be offered within the Bachelor of Science in Mathematics program. Including advanced statistics, data mining, predictive analysis and business disciplines such as marketing, operations & systems management and management information systems, the concentration will provide a combination of skills and underlying concepts that today's employers seek.
In a cost-saving move, the Board approved a resolution to refinance bond issues from 2006 and 2008 at a lower rate of interest.
Granted emeritus rank to Peg R. Gale, retired dean of the School of Forest Resources and Environmental Science, and Martha A. Sloan, retired professor in the Department of Electrical and Computer Engineering.
Recognized four employees for more than 35 years of service to the University. They are Martha Sloan—43 years; Martin Jurgensen—42 years; Barbara Ruotsala—37 years and Thomas Grimm—36 years.
Approved submission of a grant application to the Michigan Coastal Management Program, part of the state's Department of Environmental Quality.
Heard a report that the current Generations of Discovery Capital Campaign has reached $195,328,844 as of Feb. 7, 2013. The campaign, which ends this June, has a goal of $200 million.


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Visual Chatbot Evolution: What You Need to Know
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Acellere Announces Rebranding, Changes Name to Embold
EnGenius SkyKey Puts Cloud Accessible Networks in the Palm of Your Hand
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WeWork to Borrow $4 Billion to Finance Growth
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Swit Raises $6 Million for Startup Costs
MEDSiS Partners with WTIA (World Token Issuing Alliance) to Support the Argentinian Trade Union, SUPOFEPRA to Provide a New Financial Ecosystem Built on Blockchain Using Stablecoins
Mastercard Launches Early Pay For Gig Workers
Fintech Trends that Will Transform E-Commerce in 2020
How Brands Can Leverage the Power of Influencer Marketing
Best Practices for Organizing a Successful Webinar
The Death of the PDF
91% of SMBs Think Online Customer Reviews Are Critical
Bing Ads vs Google Ads, Choose What You Need
Adaora Udoji on Her Work in VR, AR, and Mixed Reality, Switching to Tech Media, and Inclusivity
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Discussing Premium Brands and Marketing with Mode Executives, Tyler Hawes and John Pietrafesa
A.T. Kearney Releases New Study: Competing in an Age of Digital Disorder
Facebook Storyteller Awards at Cannes: Smartly.io Wins 1st Place in Two Categories
Paige Announces World's First Clinical-Grade Artificial Intelligence in Pathology
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Former SAP President Joins the Board of Antuit
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HG Insights' Elizabeth Cholawsky Named Best CEO for Women
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Home > Information Technology
4 Challenges of Cloud-Based Human Capital Management Technology
by Marianne Chrisos - January 2, 2019 January 23, 2019
Cloud-based computing software and technology solutions continue to become the norm for many businesses. In fact, Gartner suggests that by 2022, nearly 30% of all IT spending will shift to cloud-based software. Rather than having to deal with multiple installations and software licenses, as well as on-site server space issues, businesses are able get the same technology to support their business needs with much less hassle and much more accessibility than in the past.
What are the challenges of using cloud-based human capital management technology?
Human resource groups are beginning to notice the benefits of streamlined software solutions that encompass more human capital management functions. There are several reasons why using cloud-based HCM technology can be good for an organization, but businesses can also expect challenges as they integrate new software solutions. Here are some of the challenges that cloud-based HCM technology potentially poses for businesses, as well as how to handle them as they arise.
Cloud-based solutions often have robust security features built-in so that the dangers of hacking or data breaches are minimal. Still, many businesses are often hesitant to take HR files and systems, which usually include sensitive employee information, and move them to the cloud.
Other organizations find that the ease of use and accessibility that cloud-based systems offer can lead to the wrong people having access to certain data. It's crucial, then, that HR teams are properly trained in using cloud-based Human Capital Management technology to avoid security issues at all costs. It's also important that leadership and IT teams are vetting the HCM software they subscribe to, to make sure it's suited for the unique security needs of HR administration and tasks.
2. Tech support
Once a new technology is added to an organization, it immediately causes a spike in the demands put on internal IT teams. From installation and integration to troubleshooting, a new cloud-based HCM system will likely lead to a bigger demand on the resources of an IT team, so it's important to make sure that there's buy-in from all stakeholders, including IT management, when it comes time to install and manage a new HCM system.
In the past, it's possible that the departments of HR and IT didn't interact much, beyond onboarding and help desk requests, but a cloud-based program implementation will require fewer silos business-wide and better communication across the entire business enterprise. It's also a good idea to invest in an HCM vendor that offers robust tech support as part of the business subscription.
A solution that works well now will need to work just as well as the business grows. Finding an HCM solution that can handle the unique and often-changing needs of your business is important.
4. Resources
A fully integrated end-to-end HCM solution is likely to bring with it a huge influx of new, accessible data. HR professionals are not always data professionals, so this can put a burden on the staff of already-busy HR teams. It is also possible that HCM systems won't integrate well with other cloud-based systems, limiting data access and data cohesion.
One question to ask when vetting cloud-based human capital management vendors is if they are compatible with already existing systems. It might also be a good idea to invest in a cloud-based HCM system that's an add-on or existing part of a cloud-based CRM that's already in use by your business.
While technology often offers businesses plenty of perks, including ease of use, simpler upgrades, competitive advantage, and more data with which to make business decisions, it can also include new challenges, particularly around implementation and adoption time. But with the right software vendor, proper HR training, and appropriate IT support, adding cloud-based Human Capital Management technology to your software lineup will likely be a smart decision that will help you better handle all aspects of human capital management.
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Marianne Chrisos
Born in Salem, Massachusetts, growing up outside of Chicago, Illinois, and currently living near Dallas, Texas, Marianne is a content writer as a company near Dallas and contributing writer around the internet. She earned her master's degree in Writing and Publishing from DePaul University in Chicago and has worked in publishing, advertising, digital marketing, and content strategy.
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New Study States Digital Marketers Find Providing Consistent Omnichannel Experiences
Global B2C marketing automation company, Selligent Marketing Cloud, announced the findings of a study that polled marketers about the integration of their technology stack to deliver an immersive, consistent customer experience. For more information on this subject, visit http://www.TechFunnel.com *** Subscribe to TechFunnel.com HERE: https://www.techfunnel.com For more content from TechFunnel.com, click HERE: https://www.techfunnel.com Watch The Thought Funnel and other interviews HERE: https://www.youtube.com/watch?v=i-KIVyv90UU&list=PLXKWh-2_8AaMK94PdgC5pm3chJHcvD4an Like TechFunnel.com on Facebook HERE: https://www.facebook.com/TechFunnelOnline/ Follow TechFunnel.com on Twitter HERE: https://twitter.com/tech_funnel Follow TechFunnel.com on Instagram HERE: https://www.instagram.com/tech_funnel_online/ TechFunnel.com is an ambitious technology-focused digital channel dedicated to highlighting the economy of information and the massive intersection of business and technology. We offer useful information, news, tools, and recommendations about what is new in the industry, where technology is headed, and how it can help you improve your personal and professional life. The goal of TechFunnel.com is to keep businesses and consumers on the cutting edge of need to know information about the people, product, companies, and innovations that are changing the world.
SEMI Announces Launch of Project to Speed Technology Development with AI
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Google Launches Initiative for Small to Midsize Businesses
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Caught on Camera: E-Cigarette explodes on Fresno bus
by: Patrick Nelson
Posted: Dec 21, 2016 / 11:52 PM PST / Updated: Dec 22, 2016 / 11:05 AM PST
Some dangerous moments inside a Fresno city bus are caught on camera. Investigators say the explosion was caused by a battery powered e-cigarette. First responders say the man in his 50s escaped with minor burns to his hand and thigh. The e-cigarette explosion was caught on camera adding to the national evidence of the damage this smoking device can do.
Wednesday afternoon a Fresno city bus driver noticed one of his passengers broke the rules by using an e-cigarette on the bus. The diver told the passenger he "can't vape on the bus". Just moments after the man put the device away in his pocket chaos erupted as the e-cigarette smoking device exploded sending him to the hospital.
First responders took pictures of the charred e-cigarette battery. Industry expers say it's most likely the source of the blast.
"These batteries they are fragile. They have a wrap on the outside that needs to stay intact. If that battery gets torn and starts to touch metal, or loose change in your pocket or something like that it can definitely short out the battery, said Adam Wooddy the owner of Satyr Vapor.
Wooddy runs Satyr Vapor in Fresno. He's familiar with e-cigarette explosion cases across the country including this one a few weeks ago, also in a man's pocket, inside a New York liquor store.
"It's terrifying to see people hurting themselves and blowing up. There's a lot of videos out there," said Wooddy.
Wooddy says this e-cigarette blast in Fresno is another example of the real danger e-cigarettes can pose if not carried properly.
"I've always told people make sure you are researching. Make sure you know what you are doing if you are getting into this because it can get dangerous," said Wooddy.
Experts say best practice is to remove e-cigarette batteries between uses, placing them in a protective case.
For those heading back out on Fresno city buses this shocking video if fresh in their minds.
"I had no idea those things would explode. I thought it would be just like any other battery. I guess if they are that dangerous we should be careful," said Virginia Alvarez, who rides the bus.
According to the Associated Press there were roughly 60 people injured by exploding e-cigarettes in 2015, but that number may be under reported because many hospitals have just started keeping record of these cases.
Lawmakers are hope to soon to impose regulations on e-cigarettes that will make them safer.
by Heather Prusak / Jan 16, 2021
ORCHARD PARK, N.Y. (WIVB) - We always hear the Bills talk about playing "complimentary football" and while that might sound cliche, it's something this team does very well and Saturday's 17-3 win over the Ravens to advance to the AFC Championship game, was another example of that.
On a night where the offense wasn't off to a fast start and only found the end zone once, the defense was there to help lighten the load as defensive back Taron Johnson intercepted Lamar Jackson in the third quarter and took it 101 yards to the house for his second pick-six of the season.