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A Border Patrol agent lights a path for asylum-seeking migrants from Central America as they navigate through thick brush Nov. 6, 2022, after being smuggled from Mexico and across the Rio Grande into Roma, Texas. (CNS photo/Adrees Latif, Reuters)
Agencies in Texas archdiocese assist immigrants, refugees seeking asylum
By Jo Ann Zuniga
Catholic News Service Filed Under: Feature, Immigration and Migration, News, World News
HOUSTON (CNS) — Casa Juan Diego and Catholic Charities, recuperating from an overflow of Venezuelans seeking asylum from their country's economic and political spiral this summer, may have to brace themselves for another possible surge this holiday season.
A federal judge Nov. 15 blocked Title 42 — a public health rule that has allowed U.S. authorities for health reasons to expel more than 1 million migrants who crossed the U.S.-Mexico border. Before that ruling, the U.S. closed its border Oct. 12 to Venezuelan migrants fleeing an authoritarian government and seeking asylum.
The order halting Title 42 handed down by Judge Emmet Sullivan of the U.S. District Court takes effect at midnight Dec. 21.
"People arriving in the United States find us on their own or in many cases, they are sent to us by ICE (U.S. Immigration and Customs Enforcement)," said Louise Zwick, founder and director of Casa Juan Diego, a Houston nonprofit shelter that depends completely on donations.
A migrant child from Venezuela plays with a pay phone in front of a shelter in El Paso, Texas, Sept. 1, 2022. (CNS photo/Jose Luis Gonzalez, Reuters)
"All these past months, we were begging for help and all our houses were so packed and overflowing with people everywhere," Zwick told the Texas Catholic Herald, newspaper of the Archdiocese of Galveston-Houston. "Our young volunteers were working their selves into the ground."
"We receive requests from California, Arizona and other places from groups helping new arrivals," she added. "Our largest numbers continued to come until about a month ago. Our beds still fill up each day, but we do not need as many additional cots now."
That may change since the November court order leaves the Biden administration without one of the key tools it had deployed to address the thousands of migrants arriving at the border on a daily basis and could restore access to asylum for arriving migrants.
For months over the summer, buses and planes from the U.S.-Mexico border carried tens of thousands of men, women and children from Central and South America to New York, Chicago, Washington and even Martha's Vineyard in Massachusetts. They were organized by Republican governors of Texas, Arizona and Florida and the Democratic mayor of El Paso, Texas, paid for mostly by taxpayers.
Texas Gov. Greg Abbott, in news reports, said the arrivals would give liberal, sanctuary cities "a taste" of what his state has had to deal with for years. Many of those were Venezuelans fleeing poverty, violence, and authoritarian rule and hoping to apply for asylum. In the latest transfer after he won the November election, Abbott sent another busload, including a child who was dehydrated and feverish, to Philadelphia where she was immediately hospitalized.
The asylum process can take years and, for much of that time, these immigrants aren't allowed to work. Zwick and those assisting them said caring for these new arrivals has been a big challenge, drawing attention to a long-standing bipartisan failure to fix the nation's broken asylum system.
More than 7 million people have fled from Venezuela to different countries to escape the political, social and economic chaos. It's the second-largest refugee crisis in the world after Ukraine, according to news reports. About 187,000 Venezuelans who crossed the border from Mexico into the U.S. last year have been allowed to stay here while they apply for asylum.
The program is modeled after a similar effort for Ukrainians, who began flying into Mexico after the Russian invasion in February, seeking to join friends or relatives in the U.S. Since that program began, the U.S. government has received more than 160,000 requests to sponsor Ukrainian citizens, according to the Department of Homeland Security.
People in El Paso, Texas, march April 10, 2021, to launch the new "We Are the 11 Million" campaign demanding immigration reform for all immigrants in the U.S. without documentation. (CNS photo/Jose Luis Gonzalez, Reuters)
About 112,000 Ukrainians have been approved, and more than 77,000 have already arrived through the program called "Uniting for Ukraine." Another 111,000 Ukrainians have arrived outside of the program since late March, according to the department.
Catholic Charities of the Galveston-Houston Archdiocese has been awarded funds from the Federal Emergency Management Agency to help migrant families who recently crossed the U.S.-Mexico border travel through a new transfer center and temporary shelter, said communications director Betsy Ballard.
The temporary shelter, in partnership with the Church of Jesus Christ of Latter-day Saints, has helped hundreds of people by providing food, basic services and a hotel room for migrants passing through the Houston area to families who are sponsoring them.
"We provide buses, and they almost never stay in Houston. They are traveling on to their destinations," Ballard said.
But the FEMA funds of $2.8 million for the transit center will likely be depleted soon, she said.
Meanwhile, Casa Juan Diego continues to help large numbers of people seeking "posada," Zwick said.
"We give groceries on Tuesdays, Thursdays and Saturdays mornings. Our new guests and many volunteers help with the food distribution," she said. "We continue to assist about 225 very ill or paralyzed individuals and their families with living expenses, food and medical supplies."
"We have been surprised and overwhelmed by the requests coming in from hospital social workers asking us to help more and more very ill undocumented people coming out of hospitals. We are just a few of us with donations, and we cannot provide for the whole large undocumented population who is ill," Zwick said.
Zwick said donated canned meats, canned vegetables, apples and other fresh fruit, as well as toiletries and clothes, are also helpful, especially with the colder weather and holidays approaching.
Lazaro Contreras, director of the archdiocesan Office of Hispanic Ministry, hosted a group of about 15 Hispanic church leaders at Casa Juan Diego to possibly volunteer or recruit volunteers.
"The purpose was to create awareness and open the possibility of volunteering in pastoral care and accompaniment of migrants," Contreras said. "On my personal time, I started volunteering at Casa Juan Diego once a week on Mondays for two or three hours in the evening."
"I have talked with people from Africa, Nicaragua, Colombia, Guatemala, Mexico, Cuba and mostly Venezuela," Contreras said. "Each of them has experienced very traumatic events in their journey. It is a blessing to help them."
Zuñiga writes for the Texas Catholic Herald, newspaper of the Archdiocese of Galveston-Houston.
Read More Immigration & Migration
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Copyright © 2022 Catholic News Service/U.S. Conference of Catholic Bishops
Jo Ann Zuniga


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Opportunities for UK companies as a new cargo line is due to be built and reconstruction work takes place on another line.
The Hungarian railway network is extensive offering links to the Balkans and to the East, connecting the country to the western markets. A significant amount of trade is done by rail within the Carpathian basin.
The network is 8057 kilometres long and is quite centralised with Budapest serving as a hub. The percentage of the electrification is relatively low as only 2911 km of the total 7802 km standard gauge network is modernised. A broad gauge is used mainly in the post-soviet region. Therefore it is beneficial for Hungary having a logistics centre in Záhony (on the border to the Ukraine).
Corridor number IV and V of the Pan-European Network runs through the country. Hungary is also involved in the development of cargo freight corridor number VI. The freight transport market is liberalised and there are private companies operating in Hungary, but the local market is largely dominated by an Austrian company.
In the current budgetary cycle of the EU between 2007 and 2013 funds were allocated to raise the quality of the network and the service. This included the modernisation of the cargo hub in Záhony whereas several lines got renovated or projects are currently underway. Hungarian State Railways have purchased carriages in this budgetary cycle and a GSM-R system is network is built right now.
Good references are a must. As there is a strong Austrian and German presence in this sector, it is important to have personal, informal contacts that can be made at major trade fairs and exhibition. The majority of the large scale infrastructure projects are published in the Tenders Electronic Daily and in the Hungarian Procurement Gazette.
Local market knowledge is inevitable to participate at procurement procedures. UKTI Budapest strongly recommends interested British companies to appoint a legal adviser and/or a procurement specialist as local regulations are relatively strict. Having a link to the decision makers and the industry people in advance is key to success.
More about doing business in Hungary.
Gabor Imeli, British Embassy Budapest Tel: +36 (1) 429 6254 or email: gabor.imeli@fco.gov.uk.


At Eimpound we understand what a pain it can be to secure accurate lien holder information through traditional channels. So, we developed a unique solution that does the heavy lifting for you - so you can focus on productivity.
Logging in and using Eimpound's interface is effortless. It cuts your research time and gets vehicles back to lien holders quickly.
Users can enter one VIN or tag at a time, or can attach a batch file to identify lien holders of multiple vehicles simultaneously.
Eimpound has approximately 85% of U.S. lien holders in its database. That's about 30 million active liens!
In addition to the primary database, Eimpound also searches all other public and private sector lien record databases in 50 states.
Users can set up an automatic batch feed to Eimpound on a timely basis (daily, weekly, monthly) to help streamline operations.
The new Eimpound app lets users scan VIN barcodes with Apple or Android tablets and phones, to deploy searches while standing right next to the vehicles.
After just a few moments of setting up, you'll be off and running - absolutely free!
You can key in the number or scan the VIN bar code with a mobile device and our free app.
Eimpound finds the lien holder and owner, sends you an e-receipt and contacts the lien holder.
How can Eimpound be free?
Unlike expensive tools out there, Eimpound is a no-charge service. Naturally, we need to generate income to remain a successful business, and that funding comes from lenders, insurers and others who pay fees to monitor their VINs through our Locator Technologies LLC database.
Do you have every VIN in America?
Close. It's difficult to gather them all, but Eimpound has access to more than 85%, with additional outreach tools to search VINs that aren't immediately retrievable.
How do I know Eimpound was successful in finding the lien holder?
If a match is found in the database, Eimpound sends you an e-receipt with the contact information for the lien holder AND sends the lien holder an electronic notification as well. If there is no initial match in the eimpound database within the next two business days Eimpound will search other lien record databases.
Does the mobile app take a picture of the VIN and send it?
No, when you use the app with a mobile device, it scans the VIN bar code, and then sends that code to Eimpound for retrieval of the lien data.


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Armenia, Caucasus, Azerbaijan
Armenia to create nationwide civilian militia
The move comes as tensions with Azerbaijan continue to mount. But some in Armenia have objected to what they see as a further militarization of society.
Ani Mejlumyan Sep 25, 2020
Armenian first lady Anna Hakobyan has announced a new program to offer young women military training. (photo: annahakobyan.com)
Following the heaviest fighting between Armenia and Azerbaijan in years, Armenia has proposed the formation of a nationwide voluntary militia to supplement the country's armed forces.
The proposed militia would be open to both men and women and would accept people up to age 70. The militia units would be organized under local governments, and members wouldn't be issued weapons except in case of military operations or the threat of operations. The militia could total up to 100,000 members.
The Ministry of Defense at the end of August introduced a draft law in parliament creating the militia, and MoD officials have expanded on the idea since then.
"In conditions of the existing and developing threats and risks around Armenia, and new belligerent statements from the neighborhood, the resources of solely the active armed forces could certainly not be sufficient," Defense Minister Davit Tonoyan told reporters in parliament on August 28.
Whenever fighting breaks out between Armenian and Azerbaijani forces, local media is replete with reports on volunteers who want to go to the front lines and fight. That included the fighting on the Armenia-Azerbaijan border in July, the heaviest fighting between the two sides since 2016.
Deputy Minister of Defense Gabriel Balayan said that the new militia would be an attempt to systematize that process. "The July events didn't demonstrate, but verified the need for such a structure," Balayan told the news website civilnet.am on September 2. "It is more effective to have an organized structure."
While tension between the two sides is the highest it's been in many years, Balayan insisted that the decision to create a militia isn't a response to recent events. "We are expecting war at every single moment. It is wrong to try to connect this to some anticipation of war. We have to be ready at all times," he said. In the case of a real war, he said, "we need this number [100,000] for military support."
An apparently unrelated program will offer a military training program to young civilian women. The women's program was rolled out by Anna Hakobyan, a journalist, the wife of Prime Minister Nikol Pashinyan, and the initiator of a program called Women for Peace. Hakobyan announced the program on September 19; it would offer women aged 18-27 a 45-day basic training program, after which successful participants could join the regular armed forces.
To some, the new programs herald a new era of militarization in Armenia.
In 2017, the government announced the "Nation-Army Concept," which envisaged a wide-ranging mobilization of society in the service of national security. The program was heavily promoted by the former regime, which was led by former military commanders from the war over Nagorno-Karabakh in the 1990s. But that government was toppled in 2018 by Pashinyan, a journalist with no military experience, and the concept was never implemented.
The program was controversial among some in the former opposition, as it appeared to be further militarizing a society that was already deeply militarized. The Bonn International Center for Conversion, a German peace NGO, classified Armenia as the third most militarized country in the world in 2018.
Some, however, have seen the new programs as a continuation of the former regime's strategy.
"This is a logical continuation of the "Nation-Army Concept," which we had thought we had drifted away from," Edgar Khachatryan, the chairman of the NGO Peace Dialogue, told civilnet.am. "But we now see many small and big programs being implemented by the MoD under that philosophy."
Khachatryan said that Armenia lacks the democratic institutions that could manage the risks created by the militia.
"As a result we will have a big group of people under MoD regulation but also in the shadows … It is hard to regulate a body which is under and at the same time out of MoD control," Khachatryan said, adding that the militia will also not be subject to oversight from parliament.
In the future, it could be used for political ends, he warned.
"When democratic institutions are weak this carries big risks in terms of using military for political goals," he said. "Now I don't see such an intention in current authorities but when there is an institution created, mechanisms at place, this means there are no guarantees because other political powers after this one could use it."
The human rights group Helsinki Citizens' Assembly of Vanadzor published a report objecting to the creation of the new militia.
The idea "is a continuation of the Nation-Army Concept proposed under the former government, which in its essence was aimed at the militarization of the entire population of the state," the authors wrote. "We have repeatedly spoken about the need to establish a professional army, when the state will solve the problem of defense and security of the country by involving citizens for whom the military profession is their main occupation, and instead, now an attempt is being made to turn the entire population into soldiers."
MoD officials have dismissed such concerns. "This is not a militarization; it is bringing the public and army closer," Balayan said at a September 1 press conference.
"Citizens will not be freely provided with weapons," Balayan said. "We plan for their involvement to take place only under the conditions of military operations and military threat. Weapons will be distributed to the militia members only when military operations start in a specific place or if there is a threat of that happening. It doesn't mean that armed people will be walking around the city."
Other analysts said the move was justified by the ongoing threat posed by Azerbaijan.
"Many pacifists call this a militarization. I personally don't see it," said analyst Sosi Tatikyan in an interview with news website factor.am. "The latest events in Tavush [the border region where the July fighting took place] once again proved that we have to be always alert and have the ability to defend ourselves."
Ani Mejlumyan is a reporter based in Yerevan.
BP announces new Caspian drilling campaign

redpajama_set_name: RedPajamaCommonCrawl


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CDO Summits
NYC 2016 Thomson Reuters
London 2014 BBC
NYC 2014 Time Warner
CDO of the Year
CDO Club Names Starbucks Coffee Company's Adam Brotman U.S. Chief Digital Officer of the Year 2015
Adam Brotman named US CDO of the Year 2015 by CDO Club
NEW YORK, April 29, 2015 – CDO Club, the world's first and largest community of C-suite digital leaders, with over 1,000 members, today named Adam Brotman, Starbucks Coffee Company's Chief Digital Officer, the 2015 U.S. Chief Digital Officer of the Year.
Brotman was named the recipient of the award during CDO Club founder David Mathison's keynote presentation, "Hall of Fame: CDOs Who Have Become CEO and Board Directors," at the 3rd annual CDO Summit, sponsored by Capgemini, on Wednesday, April 29, 2015, and hosted at Thomson Reuters in New York City.
Adam Brotman's US CDO of the Year 2015 Acceptance Speech
"I really want to thank you for this recognition, but I can only accept this on behalf of the entire cross-functional team at Starbucks who work every day to bring our digital platforms and experiences to life. Everything we do is a team effort here, and so this recognition belongs to the team more than me.
I wish I could be there in person, of course. And would have been – but I am in Dallas at the quarterly Neiman Marcus board of directors meeting today, and couldn't get there in time.
I am intrigued and impressed by the work and energy around the CDO Club. Have been for years. As your members know better than anyone else, the concept of a top "digital" leader in an organization is a relatively new concept for almost every single company that is not a traditional "tech company'. This new – and somewhat amorphous – function sits at the intersection of technology, marketing, design, strategy and operations. Now every company is realizing that they have to become a 'tech company' in some ways, and wrestling with what it means from a strategic, brand and organizational perspective. So having a forum of C-suite digital leaders to compare notes and learn from one another is critical and super helpful. Thank you for everything you are doing."
Brotman joined Starbucks in April 2009, and under his leadership the company has become a leader in mobile payments, with more than 18% of its U.S. store transactions occurring via mobile. Additionally, the company processes more than 8 million mobile payments per week.
Starbucks Coffee Company's Adam Brotman named U.S. Chief Digital Officer of the Year 2015 http://t.co/hVRupbPNm0 congrats @adambrotman!
— Ben Straley (@bstraley) April 30, 2015
Brotman also led the team responsible for piloting Starbucks Mobile Order & Pay in 2014, a mobile ordering feature integrated within the Starbucks app that allows customers to place their order as well as pay for their food and beverage items in advance of visiting their store. The feature has been rolled out in 650 locations in the Pacific Northwest.
The program has resulted in Goldman Sachs choosing Starbucks Corporation as its "top pick in restaurants," reported the Wall Street Journal.
Brotman previously served as Starbucks senior vice president and general manager of Digital Ventures, where he led the enterprise digital platform strategy, roadmap, and delivery for core Web and mobile offerings, including the Starbucks Digital Network, Wi-Fi, StarbucksStore.com, Starbucks mobile apps, and Starbucks.com.
Before joining Starbucks, Brotman was CEO at Barefoot Yoga Company, a Seattle-based e-commerce company. He served as senior vice president at the digital image licensing and e-commerce company Corbis, and founded PlayNetwork, Inc., a leading provider of in-store digital media and entertainment services for businesses worldwide.
[bctt tweet="Mobile Order and Pay team leader @adambrotman given 2015 CDO of the Year Award @Starbucks http://ow.ly/MBfXz" via="no" url="no"]
"With this award," Mathison remarked, "we recognize Adam's leadership skills and exemplary accomplishments, specifically:
Tenure: Over 6 years at Starbucks in increasingly critical roles;
Team player: Adam collaborates well with his peers across the C-suite, specifically with the CIO and CMO;
Mentor: He is a coach and mentor not only to his team, but also to CDOs everywhere;
Achievements: Adam has had numerous successful, enterprise-wide launches;
Strategy and Board service: We also recognize Adam for serving on the Board of Directors for the Neiman Marcus Group."
Mathison continued, "Adam is an inspiration, and we're proud to select him as U.S. CDO of the Year 2015."
CDO Club names Starbucks Coffee Company's Adam Brotman US CDO of the Year 2015
This is the third CDO of the Year award given in the U.S. by the CDO Club.
[bctt tweet="Third Annual US CDO of the Year Award given to @Starbucks @adambrotman for 6 years of digital innovation http://ow.ly/MBfXz" via="no" url="no"]
The first-ever CDO of the Year award was bestowed in February 2013 on Teddy Goff, who served as Digital Director at Obama for America in 2008 and 2012.
The second award was given in April 2014 to Rachael S. Haot, former Chief Digital Officer of New York City in Mayor Michael Bloomberg's administration, and currently serving as Chief Digital Officer of New York State in Governor Andrew Cuomo's administration.
About the CDO Club
The CDO Club is the world's first and largest community of C-suite digital leaders. We provide our 1,000+ members with breaking news, original research, career development support, networking opportunities, and inspirational events, such as the CDO Summit. More: http://CDOClub.com
About the CDO Summit
The CDO Summit addresses the challenges and opportunities arising from Big Data, the cloud, digital disruption, and social and mobile media. Our gatherings include some of the best digital strategists and practitioners on earth, in intimate, collegial, and supportive environments designed to encourage networking, learning, and knowledge-sharing. More: http://CDOSummit.com
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If you are tasked with understanding what digital leaders must do in order to succeed in almost any industry, the best place to learn more is at the Chief Digital Officer Summit.
Take advantage of our Super Early Bird Discount for Amsterdam, London in October 2015, Sydney in February 2016, NYC in April 2016, and Toronto in July 2016. Reserve your place now:
The CDO Summit is the "must-attend" digital event of the year. The 2013 and 2014 CDO Summits received stellar endorsements from dozens of speakers and attendees alike:
"The Chief Digital Officer Summit was engaging as much as it was informative. Bringing these incredible leaders together in one place and for one day speaks to David Mathison's extensive network, his ability to understand the needs of his clients, and to be ahead of the curve in this important space. It was a great use of my time, and I learned more than I ever thought I would. Great networking as well!"
Sandy Soto
VP Executive Talent Acquisition
HSNi
"The Chief Digital Officer Summit was a very relevant topic for today's times. I was impressed by the caliber and diversity of the panel speakers, all of whom had something unique and valuable to offer. A great opportunity to learn from the best."
Amanda Jones-Orengo
Towers Watson
"Sometimes a conference comes along that hits the trifecta – hot topic, high-caliber attendees, and stellar location. The first Chief Digital Officer Summit reached that mark with ease, and I look forward to attending the next one."
Eric Hellweg
Managing Director, Digital Strategy/Editorial Director
"The Chief Digital Officer Summit was outstanding. Why? Candid panels with top players in the digital community. Splendid break-time conversations. And, savvy facilitation, Mathison Style."
Margaret Molloy
Velocidi
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Home December 1 2016 Vol. 36 No. 21 Columns Biopharmaceutical Manufacturing Growing Rapidly in China
December 1 2016 Vol. 36 No. 21
Biopharmaceutical Manufacturing Growing Rapidly in China
Eric S. S. Langer
December 1, 2016 (Vol. 36, No. 21)
Eric S. S. Langer President and Managing Partner BioPlan Associates
More and More Firms Are Setting Their Sights on Genuine, Major Market Acceptable Biosimilars
Bioprocessing in China, particularly manufacture of biopharmaceutical products, has been on a trajectory for rapid growth. Besides developing a domestic biopharmaceutical manufacturing base to serve its own very large population, Chinese biopharmaceutical companies, often aided by central and regional governments, are increasingly preparing to become major global suppliers, including manufacturing to the GMP standards of highly regulated major markets, e.g., U.S. and EU.
For most biologics in China today, this involves what are sometimes called "biosimilars," but are more accurately "biogenerics" (i.e., not actually tested and proven to be biosimilar; no comparative clinical trials; not GMP-compliant). These are used for domestic consumption and are being sold into lesser- and nonregulated international markets.
China's growth in bioprocessing has been documented by BioPlan Associates (www.top1000bio.com), which reports and ranks known or estimated bioprocessing capacities, related employment, and products in development for the top-ranked 1,000 global facilities. More specific data from our 2016 Directory of Top 60 Biopharmaceutical Manufacturers in China, indicates substantial improvements in terms of quality processes, and increased partnering with Western companies from the first Directory, in 2008.
Chinese biopharmaceutical manufacturing capacity (total/cumulative bioreactor volumes) has increased dramatically in recent years, along with many new companies and facilities and products in development and being manufactured. Preliminary data shows total Chinese capacity to be over 1.6 million (out of >18 million L of worldwide capacity).
Today China has about 150 bioprocessing facilities producing biologics at some stage of clinical development. In 2012, Top1000Bio covered only 105 facilities in China, with 39% growth in facilities, nearly 10% annually. Total capacity was about 1.2 million liters in 2012, with 33% growth, ≥8% annually. Most growth, particularly in terms of new facilities and companies, involves manufacture of recombinant mAbs and other recombinant therapeutics vs. vaccines and blood-derived products. Total Chinese and Indian capacities are now about the same.
China has about 150 bioprocessing facilities producing biologics at various stages of clinical development. [4x-image / Getty Images]
Biosimilars Dominate
The great majority of biopharmaceutical products currently manufactured and being developed in China are biogenerics, sold in lesser- and nonregulated international commerce and Chinese domestic markets. These biogenerics generally lack biosimilarity testing, manufacture to Western-type GMP standards, and comparative clinical trials. However, this is rapidly changing, with more companies now setting their sights and actively planning for eventual full GMP manufacture of genuine, major market-acceptable biosimilars.
Although Chinese facilities may still have a long way to, including there still being zero precedents for U.S. or European Union approvals of biopharmaceuticals manufactured in China, Western partners, such as Pfizer in Shanghai and Hangzhou, are bringing needed value to bioprocessing. And although innovative product development and manufacture is still rare in China, a number of innovator companies there are moving past R&D and into clinical-scale operations.
Global suppliers, such as GE, Pall, Sartorius Stedim Biotech, MilliporeSigma, Thermo Fisher Scientific and many others, have been physically present in this market, some for decades, and are now investing heavily in the region to bring in the necessary know-how, raw materials, and equipment to help their manufacturing customers meet GMP requirements.
Our Biosimilars/Biobetters Pipeline Database (www.biosimilarspipeline.com) currently reports 47 biosimilar-involved companies in China, nearly all developers and/or manufacturers and marketers, involved with nearly 100 biosimilars and about 20 "biobetters" (follow-ons incorporating some innovative or other significant difference(s) vs. reference products; thus not approvable as biosimilars).
The great majority or nearly all of bioprocessing facilities and capacity in China belong to these companies manufacturing biosimilar-type biopharmaceuticals.
Chinese companies are planning to use biosimilars, not innovative products, as their entry in the world biopharmaceutical industry, including highly regulated major markets, e.g., U.S. and Western Europe. Many are currently working on developing products and getting them into international commerce, then somewhat more regulated domestic and regional markets, and eventually, entry into major biopharmaceutical markets, with the U.S. the biggest market. This will involve further years of work upgrading bioprocessing, especially upgrading processing, documentation, and business practices to GMP and building new facilities.
Companies are choosing among different paths to attain these goals. For example, some are: extensively using Western consultants and licensing-in the latest technologies; adopting single-use manufacturing systems (presumed more GMP- and regulatory approvals-friendly); and planning or building large capacity facilities that will often require years before attaining near full capacity utilization (with government policies favoring facilities "going big").
Foreign Involvement in China
Nearly all of the growth in bioprocessing manufacturing capacity and facilities in China involves domestic, not foreign, companies. Although there has been some limited partnering with foreign companies in building and operating facilities, this has mostly involved classic biologics (vaccines, blood products,). Big Pharma and other established major/Western market biopharmaceutical companies have generally not been constructing their own manufacturing facilities in China, either to serve the domestic or export markets. This is unlike R&D, where most every major Western company by now has invested in and off-shored basic research and early development tasks to new, often very large, facilities of their own in China, or are off-shoring R&D to a few leading Chinese CMOs oriented to serving Western companies, such as Wuxi Apptec.
BioPlan has studied the lowest costs currently attainable for commercial-scale mAb manufacture, and found a clear consensus (among Western experts interviewed) that China, as well as India, offer few real cost advantages in the big picture, with many hidden costs and problems associated with GMP foreign manufacture.
While some calculations may show lower costs for manufacturing biopharmaceuticals in China, many critical factors are often not taken into account, such as the all-important speed to market; risks to intellectual property; the slow pace of doing business in developing regions; language, translation, and cultural differences; high import duties in bioprocessing hardware; lack of experienced staff; wage increases; etc. This is besides a general lack of bioprocessing and related regulatory expertise in China with recombinant technologies at GMP and commercial scales. Another complication is that Chinese facilities are still restricted by regulations from providing CMO services, particularly product manufacturing, to foreign companies.
There are also serious questions in China that increase risks. For example, the CFDA (Chinese FDA) recently reported that ≥80% of products approved by the agency have serious deficiencies in their clinical trials, including fraudulent or inadequate data. Although some of these claims are currently being disputed, the uncertainty creates greater investment risk. Also, it must be understood that, despite its population and rapid industry growth, usage of biopharmaceuticals, familiarity, even among physicians, and affordability remain low in China. While the country has a rich history in classic vaccines and blood products, the Chinese biopharmaceutical industry has really only started-up recently and from near zero baseline.
However, there are trends for major market/Western biopharmaceutical firms establishing manufacturing facilities in China. This includes first attempts at establishing facilities expected to readily meet major highly regulated, e.g., U.S., GMP standards. The most prominent recent moves include two GE fully modularly constructed KuBio facilities coming online in China to support Pfizer as part of its $350 million investment in a fully single-use multiple 2,000 L single-use bioreactor-based facility in Hangzhou for biosimilars manufacture, along with its Shanghai facility with several 200 L bioreactors. JHL Biotech (Taiwan) is opening a CMO facility in Wuhan with several 2,000 L single-use bioreactor-based process lines.
Eric S. Langer (elanger@bioplanassociates.com) is president and managing partner at BioPlan Associates.
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text:
<?php

class opActivateBehavior extends Doctrine_Template
{
  protected $_options = array(
    'name'    => 'is_active',
    'default' => false,
  );

  protected static $enabled = true;

  public function setTableDefinition()
  {
    $this->hasColumn($this->_options['name'], 'boolean', 1, array('default' => $this->_options['default'], 'notnull' => true));
    $this->index($this->_options['name'].'_INDEX', array(
      'fields' => array($this->_options['name']),
    ));

    $this->addListener(new opActivateListener());
  }

  public static function enable()
  {
    self::$enabled = true;
  }

  public static function disable()
  {
    self::$enabled = false;
  }

  public static function getEnabled()
  {
    return self::$enabled;
  }
}

redpajama_set_name: RedPajamaGithub


Azimut 62 is the perfect luxurious motor yacht, with impeccable indoor space, which makes it the finest choice for cruising the crystal clear sea. It holds the length of twenty meters, which makes it incredibly comfortable even for longer journeys.
Motor Yacht Azimut 62 holds three spacious cabins; one master stateroom, VIP stateroom, and starboard guest stateroom, with two double beds and one twin bed, with each having its own bathroom. It holds big modernly designed lounge area, where you can relax while cruising the sea.
The interior of the yacht is luxurious since they took care of every detail when the yacht was designed. It provides a comfortable dining area and the open flybridge, for having your meal in a more pleasant way, outside with the view. The yacht possesses paddle boars, tender, water skies and water tube for your greater enjoyment and entertainment while cruising the sea.
Usually this boat operates around Orašac, HR.


text:
NPA briefs UK pig herd on African swine fever
African swine fever Notifiable diseases Disease and welfare
by The Pig Site Editor
8 March 2019, at 1:31pm
The NPA provides a current situation report on ASF around the world and discusses the potential impacts of an outbreak on the UK pig herd.
Current situation report
In the EU there were 6,741 outbreaks of African swine fever between 2016 and 2018. To the end of November 2018 there were 1,243 current outbreaks. Around 733,706 pigs have been found dead or destroyed, although the total number of wild boar deaths is unknown.
Countries affected are Belarus, Belgium, Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Moldova, Poland, Romania, Russia, Sardinia and the Ukraine.
Defra's latest assessment in January 2019 states that the disease "currently appears to be restricted to the south-east region namely Ukraine, Romania and Moldova, with other countries reporting no outbreaks in November and December. Although it is reassuring to note that the incidence in domestic pigs has been declining since July, it remains to be seen whether the decrease in incidence is related to improved farm biosecurity. The picture in wild boar, however, is concerning and shows ASF cases are increasing particularly in the Baltic States and Poland, with a few cases also in northern Bulgaria. Thus, while control efforts may be effectively reducing incidence in domestic pigs, the wild boar population represents a significant reservoir in Eastern Europe which may hinder eradication".
In China, the disease has been reported in 26 provinces (there are only 5 left unaffected) in 113 outbreaks since August 2018. According to the latest update by the Food and Agricultural Organisation (FAO), more than 916,000 pigs have been culled in China in an effort to halt further spread. The disease has spread to all major pig producing regions.
Chinese authorities have reported that over 60 percent of the outbreaks are associated with feeding swill or catering waste to pigs. Nevertheless, there are other pathways which need to be considered, including the movement of infected pigs over long distances to market, the exposure to contaminated equipment, feed or water and vector transmission.
Impact on the UK
ASF is a significant threat to the UK pig industry – the ability for it to make large geographical jumps as seen with Belgium and the Czech Republic show how easily it could arrive here. ASF is being spread by people bringing contaminated meat into countries, probably completely unaware that it is carrying the disease, and disposing of it in a way that pigs (wild boar in most cases) can get access to it.
The UK has become increasingly dependent on its export market which is now worth £470 million a year. It took 5 years to regain trade with China after the last notifiable disease outbreak (Foot and Mouth, 2001) and this is now one of the industry's most important markets. Unfortunately, China does not recognise the EU's regionalisation strategy for controlling spread of ASF and therefore once ASF is reported in a country any exports of pigmeat from that country cease to be accepted by China.
The economic climate within the UK pig industry is not currently positive as pork prices have been dropping over a prolonged period and input costs, especially feed, have increased. Many producers are now losing money, so if ASF were to hit, we would certainly see many small family farms going out of business.
The pig industry would not be the only sector to suffer. As was the case during the 2001 Foot and Mouth Disease outbreak, if the disease was widespread, large swathes of the country would be placed under movement restrictions. This would have a significant impact on tourism and the businesses that rely on passing trade in rural areas.
UK vulnerabilities
After similar reports from Taiwan, South Korea and Thailand, the Australian border control has now also confirmed the discovery of ASF in food products being brought into the country. After increasing their efforts as the virus continues to spread globally, the authorities seized 152 pork products at Australian airports and mail centres over a 2 week period. Following testing by staff from the Department of Agriculture and Water Resources, ASF was found in 6 of them.
The biggest risk to the UK remains the import of contaminated pork products, including in consignments of pigmeat and also personal imports by travellers. UK Border Force controls provide a fraction of the level of security seen in countries such as Australia and there is a complete lack of messaging at points of entry to the UK about the risk of ASF.
There are many people that will be coming to the UK to work or visit from affected countries who will have no idea about the disease. Some may have bought local product, either as a souvenir or because it reminds them of home without realising that it could be carrying ASF.
There is also a large community of hunters that come from the UK and travel to countries in order to shoot wild boar. There is of course a risk that contaminated material could be brought back on clothes and boots or in vehicles.
Although the likelihood of any imported product reaching pigs is relatively low, we have several main points of potential access.
The most concerning is the growing feral pig population in the UK, because it is one that currently we have limited control over. The largest population resides in the Forest of Dean (see Feral Wild Boar briefing for more detail). As this population grows, the pigs are leaving the core area of the forest and entering areas frequented by humans, such as picnic sites, towns and villages. They are finding easy access to food sources, largely in domestic bins and as such could easily come into contact with discarded contaminated meat. The risk associated with ASF being identified in UK feral pigs is twofold: these animals frequently come into contact with domestic pigs on units surrounding the forest which would increase the chance of spreading the virus; plus it would be incredibly difficult to demonstrate that the disease had been successfully eradicated from the UK if it were present in feral pigs.
Secondly, 40 percent of the UK sow herd is permanently outdoors and paddocks are often near to footpaths, laybys or roads. The Classical swine fever outbreak in 2000 began in an outdoor herd situated next to a public footpath and this was thought to have been caused by a passer-by discarding contaminated meat into the paddock which the pigs gained access to. There are also many indoor pig farms that have public footpaths alongside or right through them.
Thirdly, the UK is home to a large community of smallholders and pet pig keepers that studies have shown often do not understand the risk of feeding kitchen scraps to their pigs or the fact that this activity is illegal.
Finally, there are many Eastern European workers on pig farms some of whom may well bring pigmeat product back from home without thinking. We continue to encounter a lack of understanding amongst staff in general that pork products should not be brought on farm and this includes visitors and delivery drivers.
NPA position
Whilst NPA and other industry bodies have been working with Defra and APHA on a comprehensive communications programme aimed at tackling all of the perceived vulnerabilities listed above, the key area where we have made no progress is in stepping up border controls.
We will therefore continue to insist that UK Border Force takes this issue far more seriously than it has to date and increases the level of resource dedicated to intercepting illegal imports of potentially contaminated pork, particularly from high risk countries.
We would like to see much better visible communication to passengers and lorry drivers entering the UK via ports, airports and on Eurostar about the risk of the disease and the consequence of illegally importing pork products into the UK from affected areas and discarding them in areas where pigs can gain access.
A more coordinated and effective approach to management of wild boar populations is also urgently required. NPA believes it is vital that Defra revises the currently outdated 2008 Feral Wild Boar Action plan and takes an active role in helping to shape a UK strategy for feral wild boar which includes the need for culling to reduce population sizes to manageable levels.
NPA will continue to urge pig farmers to increase their biosecurity levels in order to limit the risk of their own pigs becoming infected.
The Pig Site Editor
Just how important is the pig microbiome for productivity?
Dr Stefan Buzoianu, research and development project manager for Tonisity, discusses how better guts means better pigs means better yields.


Material & Colour – Doors + Carcasses Gala magnolia colour in a gloss and roccas oak natural finish.
❤ Love this kitchen but it's over your budget?Ask us if we can help! The seller may accept an offerHave you considered finance? Finance the whole or part of the cost with 0% finance options!
Please see below for full measurements, elements and surveyor notes. Please note, unless otherwise stated any dressings e.g. light fittings, utensils, stools, decorative items etc. are not included in the sales price.


text:
Athylia punctithorax is a species of beetle in the family Cerambycidae. It was described by Breuning in 1939. It is mainly found in the Philippines.

References

Athylia
Beetles described in 1939

redpajama_set_name: RedPajamaWikipedia


text:
Living with Parkinson's
Female Sexual Health
Mealtime & Dining Out
Assistive Technology & Devices
Traveling with Parkinson's
In women, Parkinson's may impact libido (the desire to have sex) more than performance. Do not hesitate to address libido and other changes to female sexual health with your gynecologist.
How can Parkinson's influence female sexual health?
There have been no reported issues with fertility, conception or with the birthing process in women with PD.
Women with PD have a lower rate of cesarean section and a lower rate of miscarriage compared to the average American woman.
Taking levodopa during pregnancy has not been shown to have negative effects on the development of the fetus. However, taking amantadine has shown negative effects on fetal development.
The onset of PD during the perimenopausal years of hormone fluctuations can be particularly challenging because hot flashes and drenching sweat could be part of the wearing-off phenomena as well as just part of the normal symptoms of being perimenopausal.
It is important to work with a gynecologist and a neurologist to best combine hormone replacement therapy and Parkinson's medications.
Pregnancy & Parkinson's
About 400 women under the age of 50 are diagnosed with Parkinson's disease (PD) in the U.S each year. It is unknown how many become pregnant.
Understanding how Parkinson's may affect pregnancy and fertility can help expectant mothers navigate this new and exciting time.
There have been no reported issues with fertility, conception or with the birthing process in women with PD. One recent review article concluded that in women with PD there was:
a lower rate of cesarean section compared to the average American woman
a lower rate of miscarriage compared to the average rate
Pregnancy & PD Symptoms
Pregnancy may cause changes in Parkinson's symptoms. Consult with your neurologist if you are experiencing worsening or sudden changes to your PD symptoms during pregnancy.
The literature on how pregnancy affects movement symptoms of PD is conflicted.
Several reports have indicated worsening of PD symptoms during pregnancy and in the postpartum period, but others have reported no change or even improvement during pregnancy.
A recent review showed that 52% of the women experienced improvement or no worsening in PD motor symptoms, with the vast majority experiencing no change in symptoms. Women taking anti-parkinsonian medications were much more likely to have improvement or no change in PD symptoms.
Possible explanations for worsening of symptoms include PD progression, changes in how PD medications are metabolized during pregnancy, the physical stress of pregnancy, or taking too little levodopa.
Little is known about how pregnancy affects non-movement symptoms in PD. Pregnancy can cause many symptoms that are also common non-movement symptoms in PD, such as:
Urinary frequency
Disrupted sleep or insomnia
Muscle cramping
Pregnancy & PD Medications
Treatment with medications is often recommended for people living with PD, even during pregnancy. About half of women with PD who become pregnant will have worsening of their symptoms, and this risk is much higher in those who do not take any anti-parkinsonian medications. There are no standardized or placebo-controlled studies to prove safety of anti-parkinsonian medication during pregnancy.
Levodopa is the PD medication with the most data. It was reported that there was no increased rate of miscarriage, birth complications or birth defects seen with the use of levodopa.
Dopamine Agonists
There is some evidence that the use of dopamine agonists are possibly safe to use during pregnancy, but data is limited.
Amantadine
There is strong evidence to avoid use of amantadine during pregnancy, given possible birth defects and increased risk of miscarriage with its use. Whether they have Parkinson's or not, women trying to conceive or who become pregnant should not take amantadine.
Other PD Medications
Not enough is known about COMT (catechol-o-methyl transferase) inhibitors (entacapone) or MAO-B inhibitors (selegiline, rasagiline) to comment on their safety during pregnancy.
If medications are not being used for symptom control during pregnancy, then at the very least physical therapy and occupational therapy should be utilized. Consult your OB/GYN for a recommended exercise regimen.
Breastfeeding with PD
Breastfeeding while taking PD medications is typically not advised, because so little is known about secretion of these drugs into breast milk. Levodopa, amantadine, entacapone and tolcapone are excreted in breast milk and the potential effects on the infant are largely unknown.
Levodopa and dopamine agonists may suppress lactation, but despite this, some women have successfully breastfed while on these medications.
Research on PD & Pregnancy
Even though Parkinson's is less common in women, especially of childbearing age, it certainly does occur. Women in this group are an underrepresented population. There have been no formal clinical trials conducted regarding PD and pregnancy, as pregnant women are largely excluded from medication and treatment trials due to fear of effects on the fetus.
Having more data and knowledge about pregnancy and PD may improve quality of life for people with PD who are of childbearing age. Collecting this data would help medical professionals develop guidelines for giving the best care during pregnancy.
Page reviewed by Dr. Tracy Tholanikunnel, Assistant Professor of Movement Disorders at the University of Florida, a Parkinson's Foundation Center of Excellence.
Rubin SM. Parkinson's Disease in Women. Disease-a-Month. 2007;53(4):206-213. doi:10.1016/j.disamonth.2007.02.002
Subramanian I, Mathur S, Oosterbaan A, Flanagan R, Keener AM, Moro E. Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies. Mov Disord. 2022;37(3):444-455. doi:10.1002/mds.28921
Seier M, Hiller A. Parkinson's disease and pregnancy: An undated review. Parkinsonism Relat Disord. 2017;(40):11-17. http://dx.doi.org/10.1016/j.parkreldis.2017.05.007.
García-Ramos R, Santos-García D, Alonso-Cánovas A, et al. Management of Parkinson's disease and other movement disorders in women of childbearing age: Part 1. Neurol (English Ed. 2021;36(2):149-157. doi:10.1016/j.nrleng.2020.05.015
Kranick SM, Mowry EM, Colcher A, Horn S, Golbe LI. Movement disorders and pregnancy: A review of the literature. Mov Disord. 2010;25(6):665-671. doi:10.1002/mds.23071
Pregnancy and Fertility with Parkinson's
Parkinson's Q&A: How do I talk to my children about Parkinson's disease?
The Unmet Needs of Women with Parkinson's
Intimacy and PD
Episode 63: Navigating Sexuality and Intimacy with PD
Key Questions For Your Doctor's Visit
Parkinson's Foundation Helpline
Contact 1-800-4PD-INFO or Helpline@Parkinson.org for answers to your Parkinson's questions.


Gerberge Of The Gatinais was born in 0913. She died at the age of 39 in 0952.
They had two sons and two daughters, named Geoffrey I "Grisgonelle" "greymantel" Of Aujou, Fulk, Adelaide and Arsinde.
Geoffrey I "Grisgonelle" "greymantel" Of Aujou was born in 0930 in Anjou, France. He died at the age of 56 in 0986 in Battle.
Adelaide was born in 0942 in Anjou, France. She died at the age of 84 in 1026.
Arsinde was born in 0942.


Today during Community Sport a group of FEC students had a fantastic opportunity to visit the Olympic Park as part of Motivate East and their role in keeping the Paralympic legacy alive. Students had the chance to experience, learn and play a variety of different sports such as Tennis, Athletics, Boccia and Seated Volleyball. It was such a hot day however rotating each of the sports with shade and water breaks it truly was a great day enjoyed by all. All 9 students who attended spoke about the different sports they had tried on their way back and how much fun they had with friends and other members of the surrounding community coaches. A sport that many of them tried for the first time and enjoyed in particular was the Seated Volleyball. At first many of the students struggled with the different techniques of Setting, Spiking and Digging however after some practice and perseverance they managed to play a full game with the Red Team narrowly taking the win.
Well done to all students for being such an asset to the school, their manners and behaviour around the Queen Elizabeth Olympic Park and towards the coaching team were great.


text:
namespace Selftaught.Logic
{
    using System;
    using System.Collections.Generic;
    using System.Linq;

    using Selftaught.Data.Models;
    using Selftaught.Logic.Contracts;
    using Selftaught.Common.Enumerations;

    public class QuizGenerator : IQuizGenerator
    {
        public virtual Quiz GenerateQuiz(Language lang, IEnumerable<Word> words, QuizType type)
        {
            switch (type)
            {
                case QuizType.ForeignToNative:
                    return this.GenerateForeignToNative(lang, words);
                case QuizType.NativeToForeign:
                    return this.GenerateNativeToForeign(lang, words);
                case QuizType.VerbPreposition:
                case QuizType.VerbTenses:
                default:
                    throw new ArgumentException();
            }
        }

        protected virtual Quiz GenerateNativeToForeign(Language lang, IEnumerable<Word> words)
        {
            var questions = this.GenerateQuestions(words,
                w => w.Name,
                w => w.Translations.FirstOrDefault().Meaning);

            var quiz = new Quiz { Questions = questions };
            return quiz;
        }

        protected virtual Quiz GenerateForeignToNative(Language lang, IEnumerable<Word> words)
        {
            var questions = this.GenerateQuestions(words,
                w => w.Translations.FirstOrDefault().Meaning,
                w => w.Name);

            var quiz = new Quiz { Questions = questions };
            return quiz;
        }

        protected virtual IList<QuizQuestion> GenerateQuestions(IEnumerable<Word> words, Func<Word, string> selectQuestion, Func<Word, string> selectAnswer)
        {
            var questions = new List<QuizQuestion>();

            foreach (var word in words)
            {
                var firstMeaning = word.Translations.FirstOrDefault().Meaning;

                var newQuestion = new QuizQuestion
                {
                    Question = selectQuestion(word),
                    Answer = selectAnswer(word),
                };

                questions.Add(newQuestion);
            }

            return questions;
        }
    }
}


text:
This project is based on the emoncms.org users and their REST API.

The machine in which this project is develop runs a Debian 8.7
The code is built in Python 2.7.9 with numpy 1.8.2 and pandas 0.14.1.

## Obtaining_data.py
In order to get the data from them, a dictionary with the apikeys their type of source and the if of the feeds is necesary. It is store into .csv called 'apiKeyDictionary.csv'. Originally it has four columns "key", "type" and "id" like showed in Table 1.

| key     | type              | id  |lat_long  |
|---------|-------------------|-----|----------|
| APIKEY1 | house_consumption | ID1 |lat1,long1|
| APIKEY2 | grid_power        | ID2 |lat2,long2|
| APIKEY3 | solar_power       | ID3 |lat3,long3|
*Table 1. Example of a apiKeyDictionary.csv structure*

After running Obtaining_data.py, it will add two additional columns to the apiKeyDictionary.csv. These are "start" and "end" this are the initial and final times of the feed. This is later used in the file Obtaining_weather_data.py to call to weather underground over the relevant dates to obtain weather data.


The radiation transfer code reads in an HDF5 file as input. The contents of the file have to follow a specific layout. To differentiate this format from other HDF5 files, we use the .rtin extension for input files to the radiation transfer code.
These are described in Dust, Grid, Sources, and Output respectively. In addition, a number of attributes should be set at the root level, and these are described in Root-level attributes.
Each group should have the layout described in Dust HDF5 Format or should be an external HDF5 link to an actual dust file.
The Grid group should contain two sub-groups, Geometry, and Physics, which are described below.
The Geometry group should contain three tabular datasets named walls_1, walls_2, and walls_3, which should each contain one column. The walls_1 table should contain a column x giving the x position of the cell walls as floating point values. Similarly, walls_2 and walls_3 should contain one column each, named y and z respectively, giving the y and z position of the grid cell walls.
The Geometry group should contain three tabular datasets named walls_1, walls_2, and walls_3, which should each contain one column. The walls_1 table should contain a column r giving the radial position of the cell walls as floating point values. Similarly, walls_2 and walls_3 should contain one column each, named t and p respectively, giving the theta and phi position of the grid cell walls.
The Geometry group should contain three tabular datasets named walls_1, walls_2, and walls_3, which should each contain one column. The walls_1 table should contain a column w giving the radial position of the cell walls as floating point values. Similarly, walls_2 and walls_3 should contain one column each, named z and p respectively, giving the z and phi position of the grid cell walls.
The Geometry group should contain an attribute nlevels giving the number of levels in the grid, as an integer, as well as one sub-group per level. These groups should be formatted as level_%05d (i.e. level_00001, level_00002, etc.) starting at level_00001.
Each level_* group should then contain an attribute ngrids giving the number of grids in the level, as an integer, as well as one sub-group per grid in the level. The sub-groups should be formatted as grid_%05d (e.g. grid_00001, grid_00002) starting at grid_00001.
xmin, xmax, ymin, ymax, zmin, zmax: the boundaries of the grid, as floating point values.
n1, n2, n3: the number of cells (not walls) in each direction, as integers.
In addition, the group should contain a 1-d array representing the refined array described in Octree Grids. The array should be given as an integer array instead of a boolean array.
This group describes the input quantities such as the density and optionally the specific energy of the dust. In all cases where a density array should be specified, you may also give a specific_energy array with the same dimensions - this can be used as the initial temperature, or can be used as the temperature to use for the images/SED if the number of temperature iterations is set to zero.
The Physics group should contain a 4-d dataset array named density giving the density in c.g.s in each cell. The dimensions of the array should be (n_dust, n_z, n_y, n_x).
The Physics group should contain a 4-d dataset array named density giving the density in c.g.s in each cell. The dimensions of the array should be (n_dust, n_p, n_t, n_r).
The Physics group should contain a 4-d dataset array named density giving the density in c.g.s in each cell. The dimensions of the array should be (n_dust, n_p, n_z, n_w).
The Physics group should contain a structure similar to that used to represent the geometry. The nlevels and ngrids attributes are not needed, only the nested level_* and grid_* groups. Each grid_* group should then contain a 4-d dataset array named density giving the density in c.g.s in each cell. The dimensions of the array should be (n_dust, n_z, n_y, n_x).
The Physics group should contain a 1-d dataset array named density giving the density in c.g.s in each cell. Each cell in this array should match a cell in the refined array discussed in Geometry.
This should contain one group per source. The name of the groups is not important, and the Python code uses names such as source_00001. Each sub-group will contain certain attributes and datasets depending on the source type, as described below.
type: the type of the source, given as a string. This can be point (for point sources), sphere (for spherical sources), map (for diffuse sources), extern_sph (for external spherical illumination), extern_box (for external illumination from a box), or plane_parallel (for a plane-parallel beam).
peeloff: whether to include the source when computing images with peeling-off, as a string that should be either yes or no.
spectrum, to indicate that a spectrum has been numerically specified. In this case, the group representing the source should also contain a tabular dataset with two columns: nu, the frequency in Hz, and fnu, the monochromatic flux per frequency (the exact units are not important, because the spectrum is renormalized).
temperature, to specify that a temperature has been specified. In this case, the temperature should be given as an attribute temperature, as a floating-point value.
lte, to indicate that the source should emit from the dust emissivities in the cell (this is used mainly for diffuse sources). In this case, no addition attributes need to be specified.
limb: whether to include limb darkening, as a string that can be either yes or no.
In addition to the Common attributes discussed above, a group representing a diffuse source should contain a dataset called Luminosity map containing the relative luminosity of each cell as a 3-d array. The dimensions of the grid should be identical to the density grid (see Grid).
xmin, xmax, ymin, ymax, zmin, zmax: the lower and upper bounds definining the box, as floating-point values, in cm.
theta, phi: the 3-d angle giving the direction of the beam in spherical polar coordinates, as floating point values, in degrees.
The Output group should have four attributes output_density , output_density_diff , output_n_photons , and output_specific_energy , which should be set to a string to indicate whether to output the quantity after the last iteration (last), after every iteration (all), or never (none). The density_diff quantity is the density difference compared to the input density (which will be non-zero in cases for example where one uses dust sublimation).
If you want to compute images using binning of escaping photons (not recommended in most cases as it is inefficient and causes angle-averaging of outputs), then set the n_theta and n_phi parameters, which should be used to indicate, as integers, the number of bins in the theta and phi directions respectively.
n_view: the number of viewing angles for the image/SED, given as an integer.
ap_min, ap_max: the smallest and largest apertures to use. If n_ap is 1, then ap_min should be the same as ap_max.
basic: photons are split into ones emitted or scattered, and whether they were last emitted from a source or from the dust.
detailed: as for basic, but also keeping the ID of the source or dust population last emitted from.
scatterings: photons are split into ones emmitted by sources or dust, and split by the number of times they scatter.
track_n_scat: an integer giving the maximum number of scatterings to record if track_origin is set to scatterings.
uncertainties: whether to compute and output uncertainties on the images and/or SEDs. This should be specified as a string that can be yes or no.
n_wav: the number of wavelengths/frequencies to compute the images and/or SEDs for.
If using monochromatic radiative transfer, then the minimum and maximum frequency of the image and/or SED should be specified with two attributes inu_min and inu_max, which should be given as integers giving the indices to the frequencies array (the first array element should be 1).
If not using monochromatic radiative transfer, then the minimum and maximum wavelengths of the image and/or SED should be specified with two attributes wav_min and wav_max, which should be given as floating point values, in microns.
d_min and d_max: these give the minimum and maxium depth within which to use photons for the image/SED. Unless you need this and understand the implications, you should set this to -inf and +inf respectively if inside_observer is no, and 0 and +inf respectively if inside_observer is yes.
inside_observer: whether to compute the image from an observer located inside the grid, or from an observer at infinity. This should be given as a string that can be either yes or no. In most cases you will likely want to use no.
ignore_optical_depth: whether to ignore optical depth effects when computing the image/SED. This should be given as a string that can be either yes or no, and should be set to no in most cases. This can be useful for debugging and for understanding how much optical depth effects are affecting an image or SED.
If inside_observer is yes, then the position of the observer should be given with the observer_x, observer_y, and observer_z attributes, as floating point values, in cm.
If inside_observer is no, then the origin for the peeling-off should be given with the peeloff_x, peeloff_y, and peeloff_z attributes, as floating point values, in cm. In most cases, these should be set to zero.
In addition, the group should contain a table dataset with two columns, theta and phi, giving the viewing angles as floating point values, in degrees.
The overall configuration for the model should be specified as attributes for the root group in the HDF5 file. The parameters needed are described in the following sub-sections.
python_version: the version of the Hyperion Python library used to generate the file. If you are not generating the file with the Hyperion Python library (which is probably the case if you are reading this page) then set it to '0.8.7' since that is the version for which the format in this page is described.
physics_io_bytes: whether to write out the physical quantities using 4- or 8-byte floating point values. Should be either 4 or 8 (integer).
check_convergence: Whether to check for convergence in the specific energy calculation. Should be yes or no (string).
convergence_absolute: the threshold for absolute changes in the specific energy (float).
convergence_relative: the threshold for relative changes in the specific energy (float).
convergence_percentile: the percentile at which to check the absolute and relative changes in the specific energy (float).
See Specific energy calculation for the latter three.
mrw: Whether or not to use the modified random walk (MRW) algorithm. Should be yes or no (string).
pda: Whether or not to use the partial diffusion approximation (PDA) algorithm. Should be yes or no (string).
mrw_gamma: The gamma parameter for the modified random walk as described in Diffusion (float).
n_inter_mrw_max: The maximum number of MRW interactions before a photon is killed (integer).
raytracing: Whether to do a raytracing iteration at the end of the calculation. Should be yes or no (string).
monochromatic: Whether to calculate the images/SEDs in monochromatic mode. Should be yes or no (string).
n_stats: how often to display performance stats. For the MPI-enabled code, this also determines the chunk of photons to dispatch to each thread at a time (integer).
n_initial_photons: number of photons to emit per iteration in the initial iterations (integer).
n_ray_photons_sources: number of raytracing photons from sources (integer). Does not need to be specified if there are no sources.
n_ray_photons_dust: number of raytracing photons from dust (integer). Does not need to be specified if there are no dust density grids.
n_last_photons_sources: the number of photons (per frequency) to emit from sources in the imaging iteration (integer). Does not need to be specified if there are no sources.
n_last_photons_dust: the number of photons (per frequency) to emit from dust in the imaging iteration (integer). Does not need to be specified if there are no dust density grids.
forced_first_interaction: whether to use the forced first interaction algorithm. Should be one of yes or no (string).
kill_on_absorb: whether to kill photons when they are absorbed rather than re-emitting them (useful for scattering-only calculations). Should be one of yes or no (string).
n_inter_max: the maximum number of interactions a photon can have before being it is killed (integer).
n_reabs_max: the maximum number of times a photon can be re-absorbed before it is killed (integer).
sample_sources_evenly: whether to emit the same number of photons from each source (as opposed to emitting a number of photons proportional to the luminosity). Should be yes or no (string). Defaults to no.
enforce_energy_range: whether to always reset values below the minimum and above the maximum specific energy to the bounds of the range. Should be yes or no (string). Defaults to yes.


We still lack a complete understanding of the pineal gland — but that doesn't stop us from speculating.
Located in nearly the direct center of the brain, the tiny pinecone-shaped pineal gland, which habitually secretes the wondrous neurohormone melatonin while we sleep at night, was once thought to be a vestigial leftover from a lower evolutionary state.
Indeed, according to recent research, we could be increasing our chances of contracting chronic illnesses like cancer by unnecessarily bathing its evenings in artificial light, working night shifts or staying up too late. By disrupting the pineal gland and melatonin's chronobiological connection to Earth's rotational 24-hour light and dark cycle, known as its circadian rhythm, we're possibly opening the doors not to perception, but to disease and disorder. A recently published study from Vanderbilt University has found associations between circadian disruption and heart disease, diabetes and obesity.
By hacking what pinealophiles call our mind's third eye with an always-on technoculture transmitting globally at light-speed, we may have disadvantaged our genetic ability to ward off all manner of complicated nightmares. No wonder the pineal gland is a pop-culture staple for sci-fi, fantasy and horror fandom, as well as a mass attractor of mystics and mentalists. Its powers to divide and merge our light and dark lives only seems to grow the more we take it seriously.
Discerning between the science and speculation of the pineal gland hasn't been easy since long before Rene Descartes called it the "principal seat of the soul" after studying it at length nearly four centuries ago. (Although "no evidence exists to support this," clarified Borjigin.) So here's a handy shortlist of things you should know about the pineal gland.
The current scientific understanding is that the pineal gland probably started out as an eye, and it receives signals from light and our retinas. Whether it was our only eye which shrunk into the brain once its perceptive tasks were taken care of by our two newer eyes, or whether it was a third eye with a spiritual and physical connection to previous spiritual and evolutionary states, or both, has galvanized science and speculation for centuries.
That description seems apt, given the astronomical power we have achieved in a few million yeas of evolution. While Homo sapiens' third eyes likely transformed into pineal glands along the way, today we can still find animals with photoreceptive third eyes, now called parietal eyes, like New Zealand's endangered tuatara. Fossils from other ancient creatures feature similar sockets in their skulls, making our pineal gland a candidate for an ex-eye.
Michigan University professor Borjigin and his team are hard at work on how the pineal gland and melatonin regulate our lives.
These visualizations could go a long way toward understanding how to hack melatonin, which the pineal gland secretes when we sleep and helps the brain repair and sync our bodies to Earth's rotation. Melatonin is a stunning compound, found naturally in plants, animals and microbes. A powerful antioxidant, its list of its medicinal uses only seems to grow each year, as we learn more about its ability to help with immune disorders, chronic illnesses, and neurodegeneration.
What has been recently published about melatonin is already pretty significant, especially for those looking to combat breast and prostate cancer. Harvard University School of Public Health researcher Itai Kloog and his group published a series of studies in the last few years explaining how our "modern urbanized sleeping habitat" (PDF) is a massive hormone-based cancer risk. "We have blotted out the night sky" with artificial light, wrote Earth Island Journal's Holly Hayworth," citing Kloog's research and noting that half that light is wasted anyway.
Using kernel smoothing to create density maps showing light exposure and cancer rates, Kloog's team found that another of its studies, which sourced more than 20,000 light sources by height and intensity, showed a clear association. For their two worldwide studies, they developed an algorithm to assign population weight average light exposure for every person in every city across the world, using WHO data, and again they found a clear association between cancer and light at night.
This is not to say that late-night viewing itself isn't good for the mind, especially when it comes to pineal glands and third eyes. Because pineal glands and third eyes remain singular components of an otherwise binary brain with an extraordinary past, they have stimulated some stranger explorations of their spiritual and supernatural possibility. The pineal gland's circadian dualism has achieved particular resonance with influential occultists like horror influential H.P. Lovecraft. Who, in turn, have spawned new generations of speculative talents that have used it as a quite flexible receptacle for expansive meaning.
In From Beyond, a supernaturally activated pineal gland turns mad scientists into brain-eating zombies. The recently reissued 1957 exploitation film She Devil features a "female monster" whose hyperstimulated pineal gland turns her into "a demon, a devil, a creature with a warped soul!" In both films, and many other third-eye head-trips, functions as a sexualized organ, rather than a circadian regulator. Today, some use melatonin supplements, available since the '90s, to aid with sexual dysfunction. But the pineal gland's expansive mythic and scientific history has much broader applications when it comes to folklore and entertainment.


You can download or print now this coloring pages of in 600x347 resolution and 57.39 kb. If you want more quality coloring pictures, please select the large size button. This Two Level Tourist City Bus Coloring Pagesready to print and paint for your kids.


Rochester, Minn.-based Mayo Clinic completed its "Plummer Project," the name given to its systemwide rollout of a new Epic EHR, the health system confirmed Oct. 8.
The final three sites — Mayo's campuses in Jacksonville, Fla., and Phoenix and Scottsdale, Ariz. — went live on Epic Oct. 6, placing all Mayo locations on a single integrated EHR and revenue cycle management system. About 52,000 Mayo employees are using Epic in 90 hospitals and clinics throughout the health system.
Mayo Clinic began its transition to Epic at its Wisconsin locations in July 2017, followed by some of its Minnesota locations in November 2017. Its headquarters in Rochester, Minn., implemented the EHR in May.
"The commitment and expertise of outstanding Mayo staff, Epic colleagues and implementation partners brought us to this day," said Richard Gray, MD, co-chair of the initiative. "We envision even greater collaboration among experts in delivering the patient care, research and education that are hallmarks of Mayo."
The project was named to honor Henry Plummer, MD, who created the first patient-centered health record at Mayo Clinic more than a century ago.


The past few months of the NBA offseason have seen Damian Lillard connected to a few trade rumors, primarily those suggesting that the Los Angeles Lakers could have their sights on him. However, if it was up to the man himself, he'd spend his entire professional basketball career with the same team he's played for since being picked sixth overall in the 2012 NBA Draft — the Portland Trail Blazers.
Speaking to The Athletic's Michael Scotto in an interview quoted by Bleacher Report, Lillard described how he feels it would be an "honor" if he gets to play his whole NBA career with the Blazers, given how rare it is for players to only play for one NBA team from their rookie year to retirement.
Since joining the Portland Trail Blazers in 2012, Damian Lillard has led the team to the playoffs in each of his six seasons except the first, as noted by Bleacher Report. He has career averages of 23.1 points, 4.1 rebounds, and 6.2 assists per game, and also won the 2012-13 Rookie of the Year award and made All-NBA first team honors in 2017-18. Lillard will be entering the third year of his five-year, $120 million contract extension in 2018-19, which means he won't be entering free agency until the summer of 2021. He has, however, been the subject of multiple trade rumors this offseason.
Earlier this summer, reports suggested that Damian Lillard was entertaining the idea of being traded to the Los Angeles Lakers, though such rumors were mostly based on a series of cryptic tweets he fired off in response to Twitter followers, as noted by Silver Screen and Roll. More recently, ArizonaSports' John Gambadoro tweeted that the Phoenix Suns inquired about Lillard's availability, "but to no avail." The Sporting News added that the trade offer "[didn't] make sense," considering how Lillard is the face of the Trail Blazers and how the team is not in the process of rebuilding at the moment.


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May 2016 report (PDF) Ofsted audits all adoption agencies as it does schools and nurseries. Click the link to view the latest Ofsted reports for this agency.
Thurrock Council is working in partnership with the charity Coram to develop and deliver its newly integrated Adoption Service. Coram was the UK's first children's charity, set up in 1739, and it has continued to look after children who could not live at home for the 275 years since. Together, Thurrock Council and Coram are working to ensure that the county's most vulnerable children, and their prospective adopters, benefit from the expertise and excellence in adoption social work practice that Coram has long developed and championed.
We aim to deliver a responsive and professional adoption service, to fulfill our role as a corporate parent and to meet the duties that are laid out for us in national legislation.


Dreams and Flashbacks is a photography series that captures the beauty of a shared moment. Loving yourself is the most human state, and showcasing the beauty of examining oneself and appreciating a moment in time is truly living.
What do you dream of when you're alone with your thoughts? What forgotten memories resurface when you lie in the quiet?
Joy can be found in the silence of a meditative moment for yourself. Blending reality and that which lives in our imaginations. Take a moment and see what comes to the surface.
Tags: and, dreams, flashbacks, monograph, Photography. Bookmark the permalink.


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Steve's Picks
The Revenge of Gaia: Earth's Climate Crisis & The Fate of Humanity (Paperback)
By James Lovelock
Published: Basic Books - June 5th, 2007
This book is a compelling view of the earth you stand on. The Gaia Hypothesis, formulated by former NASA scientist Lovelock and the influential paleobiologist Lynn Margulis, posits that the earth and its organisms form a self-regulating system that tends to maintain a given climate through atmospheric, oceanic, and terrestrial feedbacks. Lovelock points out the ways he believes the system has worked in the past, and discusses his grave concern about its ability to continue in the face of current greenhouse gas inputs.
Deep Survival: Who Lives, Who Dies, and Why (Paperback)
By Laurence Gonzales
Published: W. W. Norton & Company - October 17th, 2004
Gonzales fascinates his readers with this wide-ranging book that combines the appeal of the real-life adventure story with an insightful analysis of the experiences of those who survived life-threatening situations. He convincingly describes the "deep spiritual relationship to the world" that allows survivors to see through their preconceptions, accept, and effectively act in the reality where they find themselves.
The Boat Who Wouldn't Float (Paperback)
By Farley Mowat
Published: Starfire - April 1984
The hilarious adventures of Farley Mowat and his friend Jack on and about the boat they call the Happy Adventure. Filled
with rich characterizations of the many friends that Mowat makes over a
period of more than 10 summers spent on and off the shores of
Newfoundland and the islands of St. Pierre and Miquelon, Mowat's yarn
ends with the story of his extremely sketchy final sea journey from
Newfoundland to the 1969 World Exposition in Montreal.
‹ This Census-Taker up Ellen's Recommendations ›


When a defendant pleads not guilty, they are maintaining their innocence in the matter. The police, detectives, and prosecutors will have to prove the case in court beyond a reasonable doubt. The defendant will then begin to prepare for a trial.
When a defendant pleads no contest, they are not admitting guilt, but they can be punished. In this case though, it cannot be used against them in another proceeding. For example, the defendant can plead no contest to a criminal assault charge and they will be sentenced for punishment. If they are facing a civil suit, this criminal assault charge cannot be used against them. The court must consent to a "No Contest" plea.
If a defendant pleads either "not guilty" or "no contest," then the judge at the arraignment hearing will proceed to announce whether or not the defendant can post bail to be freed from custody for the duration of trial. If they are denied bail, they will remain in custody. If they are granted bail, then it is up to the defendant and his or her loved ones to come up with the money and/or bail bond so that the defendant can be released.
If the defendant pleads guilty, then they will not be granted bail because they will report immediately to their punishment.
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In the United States, if a person is a witness to a crime, they likely have no legal obligation to report it to the police. There are groups of people though who are required to report certain crimes, and it would be because of their profession. For example, doctors, nurses, law enforcement, social workers, and teachers are required to report certain crimes, like abuse and neglect, to the police, even if they just suspect that it is occurring. If these people are required to report crimes but fail to do so, they can be charged a misdemeanor and face up to 6 months in jail and a $1,000 fine.


Taking place in Trafalgar Square, London, globalhire provided ALL sound, public address and DJ equipment for the "Right Guard Xtreme Sport Vert SK8 Series". This huge event featured Europe's largest "Vert Ramp" along with some the worlds finest DJ's, Skaters & BMX stars. Click here for more.


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Q: ABP/Swashbuckle - Generating swagger docs using Swashbuckle CLI Using ABP Framework (3.3) and ASP.NET Core (3.1).
I'm attempting to generate swagger.json using Swashbuckle.AspNetCore.Cli (https://github.com/domaindrivendev/Swashbuckle.AspNetCore#retrieve-swagger-directly-from-a-startup-assembly) after compiling the application, pointing to the compiled dll using the following command:
dotnet swagger tofile --output "C:\temp\swagger" .\bin\Release\netcoreapp3.1\MyBin.dll v1
It gives me the below exception:
Unhandled exception. System.ArgumentNullException: Value cannot be null. (Parameter 'provider')
   at Microsoft.Extensions.DependencyInjection.ServiceProviderServiceExtensions.GetRequiredService[T](IServiceProvider provider)
   at Microsoft.Extensions.DependencyInjection.ServiceCollectionCommonExtensions.GetRequiredService[T](IServiceCollection services)
   at System.Lazy`1.ViaFactory(LazyThreadSafetyMode mode)
   at System.Lazy`1.ExecutionAndPublication(LazyHelper executionAndPublication, Boolean useDefaultConstructor)
   at System.Lazy`1.CreateValue()
   at System.Lazy`1.get_Value()
   at Volo.Abp.AspNetCore.Mvc.AbpDataAnnotationAutoLocalizationMetadataDetailsProvider.CreateDisplayMetadata(DisplayMetadataProviderContext context)
   at Microsoft.AspNetCore.Mvc.ModelBinding.Metadata.DefaultCompositeMetadataDetailsProvider.CreateDisplayMetadata(DisplayMetadataProviderContext context)
   at Microsoft.AspNetCore.Mvc.ModelBinding.Metadata.DefaultModelMetadata.get_DisplayMetadata()
   at Microsoft.AspNetCore.Mvc.ModelBinding.Metadata.DefaultModelMetadata.get_Order()
   at Microsoft.AspNetCore.Mvc.ModelBinding.Metadata.DefaultModelMetadata.<>c.<get_Properties>b__78_0(ModelMetadata p)
   at System.Linq.EnumerableSorter`2.ComputeKeys(TElement[] elements, Int32 count)
   at System.Linq.EnumerableSorter`1.ComputeMap(TElement[] elements, Int32 count)
   at System.Linq.EnumerableSorter`1.Sort(TElement[] elements, Int32 count)
   at System.Linq.OrderedEnumerable`1.ToList()
   at System.Linq.Enumerable.ToList[TSource](IEnumerable`1 source)
   at Microsoft.AspNetCore.Mvc.ModelBinding.ModelPropertyCollection..ctor(IEnumerable`1 properties)
   at Microsoft.AspNetCore.Mvc.ModelBinding.Metadata.DefaultModelMetadata.get_Properties()
   at Microsoft.AspNetCore.Mvc.ModelBinding.ModelMetadataProviderExtensions.GetMetadataForProperty(IModelMetadataProvider provider, Type containerType, String propertyName)
   at Microsoft.AspNetCore.Mvc.ApplicationModels.DefaultApplicationModelProvider.CreatePropertyModel(PropertyInfo propertyInfo)
   at Microsoft.AspNetCore.Mvc.ApplicationModels.DefaultApplicationModelProvider.OnProvidersExecuting(ApplicationModelProviderContext context)
   at Microsoft.AspNetCore.Mvc.ApplicationModels.ApplicationModelFactory.CreateApplicationModel(IEnumerable`1 controllerTypes)
   at Microsoft.AspNetCore.Mvc.ApplicationModels.ControllerActionDescriptorProvider.GetDescriptors()
   at Microsoft.AspNetCore.Mvc.ApplicationModels.ControllerActionDescriptorProvider.OnProvidersExecuting(ActionDescriptorProviderContext context)
   at Microsoft.AspNetCore.Mvc.Infrastructure.DefaultActionDescriptorCollectionProvider.UpdateCollection()
   at Microsoft.AspNetCore.Mvc.Infrastructure.DefaultActionDescriptorCollectionProvider.Initialize()
   at Microsoft.AspNetCore.Mvc.Infrastructure.DefaultActionDescriptorCollectionProvider.get_ActionDescriptors()
   at Microsoft.AspNetCore.Mvc.ApiExplorer.ApiDescriptionGroupCollectionProvider.get_ApiDescriptionGroups()
   at Swashbuckle.AspNetCore.SwaggerGen.SwaggerGenerator.GetSwagger(String documentName, String host, String basePath)
   at Swashbuckle.AspNetCore.Cli.Program.<>c.<Main>b__0_3(IDictionary`2 namedArgs) in C:\projects\ahoy\src\Swashbuckle.AspNetCore.Cli\Program.cs:line 72
   at Swashbuckle.AspNetCore.Cli.CommandRunner.Run(IEnumerable`1 args) in C:\projects\ahoy\src\Swashbuckle.AspNetCore.Cli\CommandRunner.cs:line 68
   at Swashbuckle.AspNetCore.Cli.CommandRunner.Run(IEnumerable`1 args) in C:\projects\ahoy\src\Swashbuckle.AspNetCore.Cli\CommandRunner.cs:line 68
   at Swashbuckle.AspNetCore.Cli.Program.Main(String[] args) in C:\projects\ahoy\src\Swashbuckle.AspNetCore.Cli\Program.cs:line 111

I've tried also creating a public class as per the Swashbuckle docs, as we are using Autofac:
    public class SwaggerHostFactory
    {
        public static IHost CreateHost()
        {
            return Program.CreateHostBuilder(new string[0]).Build(); //Calls the same builder that's used to run the app
        }
    }

The intent is to allow running this in our pipelines to auto-generate ApiClient libraries.
I'm at a bit of a loss as to how to resolve this. The swagger.json is generated at runtime perfectly fine?
Any help appreciated!

A: One way to avoid this is to make sure your program continues without these app settings
var connectionString = config["MyConnectionString"];
if (connectionString != null)
{
    services.AddDbContext<AppDbContext>(options =>
        options.UseSqlServer(connectionString));
}

A: You can get the Swagger.json in a simple way without Swagger CLI.
Run your web with the dotnet command:
dotnet  MyCompanyName.MyProjectName.Web.dll

Then download the Swagger.json with the following Powershell command:
Invoke-WebRequest -Uri https://localhost:5001/swagger/v1/swagger.json -OutFile c:\temp\swagger.json

redpajama_set_name: RedPajamaStackExchange


There will be a No Border Wall event tomorrow at La Lomita. There will be a rally, but it won't be a pure political event. Families are encouraged to attend. The Riverside Club will be providing pontoon boat rides. It should be a fun and educational experience for all who attend.
Steve Taylor has more details at the Rio Grande Guardian.