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WHY YOU SHOULD START A COMPANY IN…BOSTON
Just finished reading this interesting article by Laura Rich about a new Boston entrepreneurial boom. Check it out!
It used to be, you were serious about starting a tech company, you went to Silicon Valley. But emerging entrepreneurial hubs around the country are giving startup aspirants options. In this series, we talk to leading figures in those communities about what makes them tick. Here, part four of our series.
In the pre-Internet era of tech startups, Boston's Route 128 rivaled Silicon Valley with mammoth hardware hotshots like Digital Equipment Corp., Honeywell, EMC and Data General. But when the Internet and its new business models arrived, Boston faded, as the excitement, new ideas and, most importantly, the investment capital coalesced around the Valley.
Now Boston is back. It has never lacked for a community of smart people drawn to its world-class universities in Harvard and MIT. And it has long boasted the second largest center of venture capital. Boston can now also claim big Internet hits like Facebook, Akamai and TripAdvisor–providing the market with a boost of energy, and experienced entrepreneurs rallying angel activity. Additionally, it is benefiting from a robust moment for life sciences businesses by tapping its research hospitals. Once more Boston is bustling–and it's giving Silicon Valley a run for all that venture money.
Jeff Bussgang, a VC with Flybridge Capital Partners, recently spoke with FastCompany.com about what makes Boston's startup scene unique.
Why are you bullish on Boston?
I think there are a handful of ingredients that are required [to ignite the startup community] and I think Boston is really unique on a couple of them. So the one generic ingredient is, you need intellectual property. You need invention–science and technology–and innovation to be occurring. What I think is incredibly unique about Boston is that the university system generates so much IP. Between Harvard and MIT, between the hospital systems, there's an extraordinary amount of IP and innovation being generated and in a large part by people–and institutions–who are now experienced at commercialization.
So what's nice about MIT and Harvard and the hospital systems is that there are decades now of experience and hundreds of companies that have gone from labs to market and so if you're a promising post-doc or PhD student with a really good idea, you don't have to invent the mechanism or the process to take that idea and find the necessary pieces to actually creating a company. It's really easy because there are so many people around you who have done it before and so many resources around for that.
How does the hospital system contribute to Boston's entrepreneurial ecosystem?
Health care comprises 18% of gross domestic products in America and is going up, and science is a massive investment and innovation area in the startup world. I think Boston is very unique in that we've got this extraordinarily rich and diverse hospital system and I think we have seven or eight teaching hospitals within a two-mile radius. That results in fantastic science and basic research being done in the areas of cancer and oncology and orthopedics and every imaginable area, which results in really innovative medical devices and biotech companies.
This little state attracts so much NIH funding because it all pours into these teaching hospitals and that's the reason you get the Genzymes and the Boston Scientifics of the world–we've got these huge companies that have emerged and do acquisitions and are fueled by a lot of the research and that will lead to another important element I'll mention which is having the big companies around you. But just to stay on the IP–that's really what's so fantastic about Boston: there's always new IP being generated so when clean tech emerges–which didn't exist ten years ago, but now suddenly is this big wave of innovation–we've got this incredible laboratory system to generate innovation in clean tech and environmental sciences.
How else is Boston in a position to attract entrepreneurs?
I think you need a really vibrant venture capital community and you need a set of resources around the venture capital community that knows how to take things from idea to product. One of those is angels and mentors, experienced entrepreneurs in the culture of success. You need lawyers, you need accountants, you need real estate systems, flexibility in the real estate system. You need all of these things that just make it really easy to reduce friction. The key thing in startups is you want to reduce friction. And, you know, Boston has the second largest venture capital community in the world, the number one per capita. I made the point in my presentation that if there was more venture capital in China than in Massachusetts and you were an entrepreneur, where would you want to be? If there was two times the venture capital in China than in Massachusetts but a thousand times the population, you'd want to be in Massachusetts.The third thing you need are big companies because the big companies train the entrepreneurs on how to be good managers, because to really learn the skill of building a valuable company, it's great to go through the process and get people who have the experience of running a hundred million dollar business unit or building and selling a billion dollar company or taking companies public and recycling that talent. [In Boston], you have people who have seen success from end to end, like the early entrepreneurs at EMC or the early entrepreneurs at Akamai–if they are there from one dollar to a billion dollars, they know how to do it again.
Are there any examples of the entrepreneurial ecosystem in action, with all of these elements?
You may have heard of Tom Stenberg, the founder and CEO of Staples? So Tom was in Boston, started Staples in Boston, built it into a multi-billion dollar company, took it public, very successful. And then he started being an angel investor to other entrepreneurs.
A couple of his Staples employees started companies and then he started being a venture capitalist and then he started a venture capital fund called the Highland Consumer Fund which is funding consumer retail entrepreneurs.
So why now? What is driving a renewed energy behind Boston's startup community?
One thing I would say what's going on now is that what's happening in media and advertising is helping Boston because of the proximity to New York City. There are a lot of companies in Boston that are like DataXu that have research and development in Boston, but the business development and sales team is in New York. And it's such an easy shuttle ride. People can commute back and forth and integrate those teams very easily. The R&D team is cheaper and typically easier to recruit, cheaper and stronger and more experienced. It's harder to build a technology team in New York, I think. But in terms of business development, I mean, New York is where you've got to be because that's where the customers are.
I guess the other [reason] now is that opportunity cost has plummeted for entrepreneurs. If you are a big company executive, you're likely to get laid off, the benefits aren't as good as they used to be. You sort of look at the formula and you say, "Geez, why not do something entrepreneurial?" There are a lot more free electrons floating around.
And Boston has got such a strong student community. Every Labor Day, tens of thousands of new young people show up. And if those young people, culturally, have a passion for entrepreneurship, which I think more young people today do than they used to, if entrepreneurship is cool and the Web is cool and new technology is cool, then you're going to get more Facebooks.
BY Colin Murphy ON February 3, 2010
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Q: Group cohomology with coefficients in a permutation module (follow-up) This is a follow-up question to Group cohomology with coefficients in a permutation module (which was for the case of a normal subgroup)
Let $A$ be an Abelian group, and let $G$ be a finite group which acts on a finite set $M$ (such that the orbit of any point in $M$ is $M$).
I can define a $G$-module (i.e. Abelian group with $G$-action) $A^M$, which is the set of functions from $M$ into $A$, and the $G$-action gets inherited from $M$.
Now, consider some $m_* \in M$, and let $H$ be the subgroup of $G$ which leaves $m_*$ invariant. By restricting onto $H$ and $m_*$, I get a homomorphism in group cohomology from $\mathcal{H}^n(G, A^M) \to \mathcal{H}^n(H,A)$. Is it an isomorphism? If $H$ is a normal subgroup, then $A^M$ is the same as the co-induced module $A^G$ so I get an isomorphism by Shapiro's Lemma. But if $H$ is not normal then I'm not sure.

redpajama_set_name: RedPajamaStackExchange


text:
Overbooked This Weekend With Our September New Releases!
Remember the good old days when the weekend would pass with the blink of an eye? Restricted movement and rightful calls for social distancing however, have made the thought of spending yet another weekend at home unbearable…
Well, not under our watch! Our September new releases will have you scrambling to free your schedule this and every other week of the month! You can thank us later but for now, GET READING!
My Best Friend's Son's Wedding by Zarreen Khan
From the bestselling author of Koi Good News? comes a rib-tickling new novel about family, friends and not one but two big fat Indian weddings.
The Foundling by Stacey Halls
From the Sunday Times bestselling author of The Familiars, comes a story of two women, bound by a child, and a secret that will change everything… a captivating story of mothers and daughters, class and power, and love against the greatest of odds.
Call of the Raven by Wilbur Smith, with Corban Addison
An action-packed and gripping adventure by bestselling author, Wilbur Smith, about one man's quest for revenge, the brutality of slavery in America and the imbalance between humans that can drive – or defeat – us.
Notes from Small Planets by Nate Crowley
Journey from fantasy mountains to super-cities, through piratical seas and up into space without missing any must-see sights – or putting a foot wrong with the locals! Whether you're Lord of the shoestring-budget or Luxe Skywalker – Notes from Small Planets is your pastiche passport through the best worlds of Science Fiction and Fantasy.
Gangster on the Run by Puja Changoiwala
'A thrilling, unputdownable read from a prolific journalist!'– Rakesh Maria, former Commissioner of Police, Mumbai
Rahul Jadhav took the name 'Bhiku' after a character from the 1998 cult classic Satya – a gangster who was everything Rahul once wanted to be. Soon, he found himself shouting threats down the barrel of his gun and became one of the most wanted gangsters of his time. After his arrest in 2007, the extortionist and hitman was left a shadow of his former self, ravaged by alcoholism and drugs abuse – which twisted his mind into a near-schizophrenic state. That was only part of his journey. Today, he is an ultra-marathoner – who as covered over 3000 kilometers, including a 2019 run from the Gateway of India to India Gate – and aims to breaks the national stadium run record.
Letters to Mother by Narendra Modi, translated by Bhawana Somaaya
As a young man, Narendra Modi had got into the habit of writing a letter to the Mother Goddess, every night before going to bed. But every few months, he would tear up the pages and consign them to a bonfire. The pages of one diary, dating back to 1986, survived, however. These are now available in English for the very first time as Letters to Mother, in a powerful translation by Bhawana Somaaya.
Think Like a Monk by Jay Shetty
'Who better to help you find meaning in your life than a monk? Jay's experience and wisdom are invaluable to anyone looking to improve their life and reach their full potential.'—Ellen DeGeneres, television host, actress, writer, and producer
In this inspiring, empowering book, Shetty draws on his time as a monk in the Vedic tradition to show us how we can clear the roadblocks to our potential and power. Drawing on ancient wisdom and his own rich experiences in the ashram, "Think Like a Monk" reveals how to overcome negative thoughts and habits, and access the calm and purpose that lie within all of us.
Didn't See That Coming by Rachel Hollis
With her signature humor, heartfelt honesty and true-life stories, in Didn't See that Coming, Rachel Hollis shares how to embrace the difficult moments in life for the learning experiences they are, and that a life well-lived is one of purpose and focused on the essentials. This is a small book about big feelings, inspirational, aspirational, and an anchor that shows that darkness can co-exist with the beautiful.
Kleptopia by Tom Burgis
'A powerful, appalling, and stunningly reported exposé … It reads like fiction, but unfortunately is all too true.' – Jane Mayer, author of Dark Money
In this real-life thriller packed with jaw-dropping revelations, award-winning investigative journalist Tom Burgis weaves together four stories that reveal a terrifying global web of corruption: the troublemaker from Basingstoke who stumbles on the secrets of a Swiss bank, the ex-Soviet billionaire constructing a private empire, the righteous Canadian lawyer with a mysterious client, and the Brooklyn crook protected by the CIA.
The Hype Machine by Sinan Aral
'An immensely interesting, informative, and provocative look at the biggest technological questions of our time, and the future of our democracy.' – Eli Pariser, bestselling author of The Filter Bubble
Packed with original research conducted by Sinan Aral and his team, The Hype Machine describes the impact of social media on statecraft, politics, voting, business and public health. This is a fascinating book that provides counterintuitive and surprising answers to some of the most hotly debated topics of our connected, digital era, as it impacts society.
Solved by Andrew Wear
'Wear conversationally imparts a wealth of carefully analyzed facts that amount to far more than a glorified BuzzFeed list… insightful.' – Kirkus Reviews
By bringing together for the first time tried and tested solutions to society's most pressing problems, from violence to inequality, Andrew wear shows that the world we want to live in is already within reach. Solved is a much-needed dose of optimism in an atmosphere of doom and gloom. Informative, accessible and revelatory, it is a celebration of the power of human ingenuity to make the future brighter for everyone.
Stories of Hope by Heather Morris
'A sincere…moving attempt to speak the unspeakable.' – The Sunday Times on The Tattooist of Auschwitz
In stories of hope, Heather Morris takes us on an inspirational journey through some of the defining experiences of her life, including her profound friendship with Lale Sokolov, the tattooist at Auschwitz-Birkenau and the inspiration for her bestselling novel, The Tattooist of Auschwitz.
Sense by Russel Jones
For over a decade, multi-sensory marketing expert Russell Jones has been using the science of the senses to design products, brands and retail environments that tantalise our senses in revolutionary ways. In this incredible new book, Jones takes research from the worlds of neuroscience, experimental and behavioural psychology and beyond, and shows you how to live more multi-sensorially; paying attention to the sounds, scents, colours, objects, shapes and textures that constantly surround you, to profoundly impact and improve every aspect of your life. Sense is a fascinating and revelatory look at how you can use your senses in a way you never have before.
Nothing to Lose: The Authorized Biography of Ma Anand Sheela by Manbeena Sandhu
Manbeena Sandhu followed the Osho movement for two decades before her journey finally led her to Sheela. Nothing to Lose is a no-holds-barred account of Sheela's life, her intense relationship with Bhagwan, and the riveting story of what actually happened behind the closed doors of the cult's ashram.
The Ultimate Goal: A Former R&AW Chief Deconstructs How Nations and Intelligence Agencies Construct Narratives by Vikram Sood
In The Ultimate Goal, Vikram Sood, former chief of India's external intelligence agency, the Research and Analysis Wing (R&AW), explains 'the narrative' and how a country's ability to construct, sustain and control narratives, at home and abroad, enhances its strength and position.
Full Spectrum: India's Wars, 1972-2019 by Arjun Subramaniam
In his first book, India's Wars: A Military History, 1947-1971, Arjun Subramaniam attempted to set this right by taking readers on a journey until the liberation of Bangladesh in 1971. Full Spectrum: India's Wars, 1972-2020 takes the story forward. Covering every major operation that the armed forces have participated in, it fuses the strategic, operational, tactical and human dimensions of war and conflict into a racy narrative that reflects their changing character in modern times.
Inquilab: A Decade of Protest
'A reminder of the need to protect constitutional values' – Rajdeep Sardesai
From the Anna Andolan in 2011 to the anti-CAA-NRC movement in 2019, a fierce spirit of liberty has gripped the nation over the last decade. A Decade of Protest capture the most important events and issues of the past ten years. The anthology includes the voices of ∗ Anna Hazare ∗ Kavita Krishnan ∗ Nayantara Sahgal ∗ Rana Ayyub ∗ Kanhaiya Kumar ∗ Romila Thapar ∗ P Sainath ∗ Mahua Moitra ∗ Majid Maqbool ∗ Chandra Shekhar Aazad ∗ Nabiya Khan ∗ Ramachandra Guha
India's China Challenge: A Journey through China's Rise and What It Means for India by Ananth Krishnan
'Ananth Krishnan presents a gripping account of contemporary China, the country's stupendous progress and the dark side. His eye and intellect are probing, and he is an indomitable explorer. The effect is brilliant.' – Nirupama Rao, Former Foreign Secretary and Ambassador to China
Ananth Krishnan first moved to China in the summer of 2008. In the years that followed, he had a ringside view of the country's remarkable transformation. India's China Challenge tells the story of a complex political relationship, and how China – and its leading opinion-makers – view India. It looks at the economic dimensions and cultural connect, and the internal political and social transformations in China that continue to shape both the country's future and its relations with India.
China's Good War by Rana Mitter
'Mitter confirms his status as one of the world's leading sinologists in this lucid work as he explores fresh intellectual terrain, awakening us to China's radically different perspectives on critical wartime events.' – Kevin Rudd, former Prime Minister of Australia and President of the Asia Society Policy Institute
Chinese leaders once tried to suppress memories of their nation's brutal experience during World War II. Now they celebrate the "victory"-a key foundation of China's rising nationalism. As China grows more powerful, the meaning of the war is changing. Rana Mitter argues that China's reassessment of the World War II years is central to its newfound confidence abroad and to mounting nationalism at home. China's Good War begins with the academics who shepherded the once-taboo subjects into wider discourse.
Punching the Air by Ibi Zoboi and Yusef Salaam
'Zoboi and Salaam together craft a powerful indictment of institutional racism and mass incarceration through the imagined experience of Amal, a Black, Muslim 16-year-old facing imprisonment.' – Publishers Weekly
With spellbinding lyricism, award-winning author Ibi Zoboi and prison reform activist Yusef Salaam tell a moving and deeply profound story about how one boy is able to maintain his humanity and fight for the truth, in a system designed to strip him of both.
Blood & Honey by Shelby Murin
'Decadent and dangerous… the rich cast of characters captivated me, and I can't wait to see what's in store next for this merry band of miscreants.' – Reneé Ahdieh, New York Times bestselling author of The Wrath & the Dawn series
After narrowly escaping death at the hands of the Dames Blanches, Lou, Reid, Coco, and Ansel are on the run from coven, kingdom, and church—fugitives with nowhere to hide. To elude the scores of witches and throngs of chasseurs at their heels, Lou and Reid need allies. Strong ones. But protection comes at a price, and the group is forced to embark on separate quests to build their forces. As Lou and Reid try to close the widening rift between them, the dastardly Morgane baits them in a lethal game of cat and mouse that threatens to destroy something worth more than any coven.
The Great Realisation by Tomos Roberts
A post-pandemic bedtime tale that has captured the hearts of millions. First performed in response to the coronavirus pandemic, Tomos Roberts' inspiring poem, with its message of hope and resilience, has been viewed over 60 million times and translated into over 20 languages worldwide – a story for all readers, young or old, who dare to dream of a fairer, kinder, more loving world.
We told you you're going to be overBOOKed didn't we? Now that we've got you kitted out for the rest of the month, don't worry about the upcoming weekends – dive into your favourite book NOW!
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>> You appear to be missing SSLEnabled="true" on your Tomcat connector.
> the Bad Gateway error disappeared.
> it is because it is a different version.
likely to have known security vulnerabilities (5.5.x certainly does).
That might be an issue depending on the nature of your production system.
> Anyway, we thank you very much for your assistance.


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Q: Hosting Symfony 4 app with EasyDeployBundle on server without /usr/local/bin/composer For a Symfony 4 app I have chosen a Web Cloud plan from the hosting provider OVH.
For the deployment I have decided to use the EasyDeployBundle which looks very promising. This is my config file:
<?php

use EasyCorp\Bundle\EasyDeployBundle\Deployer\DefaultDeployer;

return new class extends DefaultDeployer
{
    public function configure()
    {
        return $this->getConfigBuilder()
            ->server('ovh')
            ->deployDir('directory/path/at/server')
            ->repositoryUrl('git@github.com:foo/bar.git')
            ->repositoryBranch('master')
        ;
    }
}

I have .ssh/config file with the following entry:
Host ovh
    Hostname sshcloud.foobar.hosting.ovh.net
    Port 12345
    User foobar

Note: all values are dummies, just for illustrational purposes.
When I run:
php bin/console deploy --dry-run -v

everything goes fine, but when I actually try to deploy I get the following error:

The command "ssh ovh 'which /usr/local/bin/composer'" failed.

The problem is that I have no write-access to the directory /usr/local/bin/ on the server. The composer.phar is in my home directory and I can't move it to the provisioned destination.
Is there any possibility to tell EasyDeployBundle to look for composer in another directory?

A: I should really read the manuals, in particular when I'm linking them in my question.
There is a method remoteComposerBinaryPath that accepts custom path to composer. I have amended the method configure like this:
public function configure()
{
    return $this->getConfigBuilder()
        ->server('ovh')
        ->deployDir('directory/path/at/server')
        ->repositoryUrl('git@github.com:foo/bar.git')
        ->repositoryBranch('master')
        ->remoteComposerBinaryPath('composer.phar')
    ;
}
On the server I created .bashrc in my home folder and added the line:
export PATH=$PATH:/home/foobar

and now the deployment is passing this hurdle.
I have now another problem, but at least this one is solved and maybe the answer can help other people too.


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The CURL Board is delighted to announce that Dr Thomas Graham, University Librarian at the University of Newcastle upon Tyne, will become the CURL Chairman with effect from July 1. This follows the imminent departure of Dr Clive Field, currently Director of Information Services at the University of Birmingham and CURL Chairman, to the post of Director of Scholarship and Collections at the British Library.
Before taking up his appointment at Newcastle, Dr Graham has held the same post at the University of York (1984-1997). Prior to this, he worked at the universities of Hull, Aberdeen and Glasgow.


text:
Research Data Collections
NSF Awards (public)
CRIF-MU: Acquisition of an X-Ray photoelectron spectrometer (XPS) for small area and depth profiling analysis
nsf.html (229bytes)
nsf145.xml (2.975Kb)
Colon, Luis Principal Investigator
With this award from the Chemistry Research Instrumentation and Facilities: Multi-user (CRIF:MU) program, Professor Luis Colon and colleagues Sarbajit Banerjee, Frank Bright, Joseph Gardella and David Watson from SUNY Buffalo will acquire an X-ray photoelectron spectrometer (XPS). The award will enhance research training and education at all levels, especially in areas of study such as (a) surface aggregation and reorganization of polymeric materials, (b) correlation of electronic structure of nanomaterials to finite size effects on material properties, (b) protein behavior dynamics in restricted microenvironments, (c) fundamental studies of silica imprinted nanostructures, and (d) linked-assisted materials assembly that have quantum dots. X-ray photoelectron spectrometers are used for chemical analysis. The XPS technique quantitatively measures elemental composition, empirical formula, chemical state and electronic state of the elements in a given material. A sample is irradiated with a beam of monochromatic X-rays and the kinetic energies of the resulting photoelectrons are measured and related to specific elements. XPS often plays a crucial role in defining the system under study. The technique requires the use of ultra high vacuum conditions. The work to be carried out by these investigators represents a wide array of systems requiring surface characterization. The instrumentation will be used in research activities and also for research training and education of a large number of students from diverse backgrounds.


text:
You are reading: "Article list"
Bauhaus Dessau Architecture
"Art and technology: a new unit" – It was with this slogan that the Bauhaus moved to Dessau in 1925/26. The seven years in Dessau were most productive for the designers and architects at the Bauhaus. This illustrated volume presents the Bauhaus buildings in Dessau in words and pictures and offers new perspectives on these icons of modern architecture.
Stiftung Bauhaus Dessau (Hrsg.) / Hirmer Verlag
Interview with Ada Karmi-Melamede
"Short Sentences That Refuse to Get Old"
Ada Karmi-Melamede is one of the voices that can be heard on the audio app of the shortly reopened Liebling House in Tel Aviv. Her father Dov Karmi is the architect of the building. An inspirational conversation about freedom of thought, architecture and rituals of a creative family.
Michael Yacobson
Utopia and disappointment
The keynote lecture by Prof. em. Dr. Lucian Hölscher was a highlight of this year's "Weimar Controversies". The former teacher at the Ruhr-Universität Bochum impressed with his profound and entertaining thoughts on "Utopia and disappointment. 100 years of the Bauhaus". Reason enough for us to publish his lecture.
Photo: © Tillmann Franzen, tillmannfranzen.com
On the role of women in the laboratory of modernism
Masters and weavers
In this Bauhaus centenary, one often gets the impression that this laboratory of modernism was a trailblazer for pretty much everything. Yet despite all the praise, a counter-question might be justified: What is not Bauhaus these days? In other words: What should we do better than the Bauhaus? Where should we take distance from it?
Photo: T. Lux Feininger, Bauhaus-Archiv Berlin / Estate of T. Lux Feininger
Modern landscape gardening and landscape architecture
The Bauhaus Perspective on Green Spaces
The Bauhaus shifted perspectives further afield. Modernism turned familiar perforated façades into glass envelopes – thereby providing an unobstructed view of the outside world. What role does the outdoors play in the Bauhaus? What is its understanding of the countryside and green areas we live in? And how does the Bauhaus period inspire the design of open spaces today?
© Greg Benson (pexels.com)
The Arab world and Modernity
Monuments for the free spirit
If you automatically think of Israel with respect to the Bauhaus and the Middle East, you probably paid attention at school. But there is also plenty of Modern architecture to discover in the Arab world.
Nicolas Flessa (2013)


The hardest part of vet school is not learning any particular subject. It is not the hours and hours spent getting used to reading thoracic radiographs. Getting into vet school was a challenge (and a pain at the time!), but I have dealt with worse things in my life. The hardest part of vet school does not involve the late hours on emergency rotations, nor does it involve discussing the quality of life options with owners concerned for their pet's well being. The hardest part of vet school is missing time with family and friends.
For me, this is an exceptionally challenging part of my academic career. I have always been at least 4 hours away from my home, and I am 8 hours away from my home while I am here in Ithaca, New York. Since I am not made of money, an airplane ride home is not a real possibility. Available time to get home and stay home for more than a few days tends to be fleeting instead of in excess. With a couple new nephews in my family and aging great-grandparents, I am counting down the days left before I can return closer to my home so that I can see these people more frequently. Even holiday gatherings take a back seat during veterinary school, making those uncommon moments when you get to see relatives that live far away even rarer.
We make a lot of small sacrifices during veterinary school. We miss out on lots of social affairs. We have intense class schedules and even more intense clinic schedules. Some of us sacrifice sleep while some of us sacrifice exercise time. But this hardest part of vet school, the time spent away from those you love, is no small sacrifice. Missing out on time with those you love is not insignificant. It is always hard for me no matter how I spin the story in my head. I understand that it is a reality of life, but that does not make it easier. Phone calls can connect us to those we love, but they are not the same as experiences in person. To remedy this sadness, I always remind myself to honor those that I love every day through my actions. It is a mantra that brings me comfort and lends itself to positive interactions with those around me.
I related so much to the Ben! Being a first year veterinary student, I knew I wouldn't have the time for the ones I love but was hopefully I could use my breaks to see them. When it comes down to it, the distance is immense and the time is fleeting. It is so hard to divvy up time to stay in touch with them. Its something that you realize will be difficult but you really don't understand until you are in it. Thank you for writing this – it really brought some feelings up as Spring Break comes to a close.
How about doing a declaw????
Times have changed. Thirty-four years a go when I entered vet school, there was no internet, no Skype, no cellphones, no real connections. I entered school with classmates from 17 states and foreign countries, many of them really far way. I also entered vet school with a wife going to graduate school at the same time and three small children-the oldest of which was five. I know about missing family time. If you want to be a vet badly enough, you must meet the demands. But, if you need help, please ask for it.


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Home defibrillators gain in popularity
CBC News interviewed W21C Researcher and PhD Student Nicole Percival about the purchasing of Automated External Defibrillators (AEDS) for home use for an article published in March 5, 2012. Nicole has extensively studied the design of AEDs in our Health Care Human Factors Laboratory.
As cardiac defibrillators become more commonplace in public spaces, some people are even buying the expensive devices for their home.
Demand for the machines is on the rise, said Brianna Welsh, a purchaser at a Calgary medical supply store.
"I'm not sure if it's that we have an aging population, or that the status of the health of our population, but that could be one of the factors," she said.
"Definitely I think it will be going up and it has been going up."
Defibrillators can help save a person who is in cardiac arrest by shocking the heart back into its normal rhythm.
Drugstores are now stocking them for the health conscious consumer.
But before spending more than $1,300, talk to your doctor to assess whether you need one, said Nicole Percival, who studies defibrillator design at the University of Calgary's faculty of medicine.
"I think it's a good idea if you're high risk population, especially if you can have your family members trained on how to use the defibrillator. Just to have them really comfortable in the use of it in case of an emergency," she said.
Officials at the Canadian Red Cross agree, but caution consumers that a defibrillator doesn't replace first aid training.
W21C welcomed the Royal Tour
Allowing a seamless transition from the hospital back into the community


Whether you are looking to browse or Get a Samsung mobile phone, then this is the best place to start. We offer the information related to Samsung phones.
With more than half of the UK population owning a mobile phone, it's not surprising to learn that a large proportion are Samsung owners.The complete range of current Samsung mobiles are shown on this page along with those that are coming very soon. Obviously those not yet released cannot be bought but they do give you an idea of what Samsung are going to release in the near future!


text:
Hands On with Google's Cardboard VR Headset
By Jane McEntegart 2014-06-26T01:00:00Z
One of the coolest products at Google I/O is made out of cardboard.
Google I/O is one of the best conferences around for swag. In general, conference swag is pretty hit and miss, but Google is known for giving out samples of its latest hardware for developers to take home and keep. In the run up to Google I/O 2014, there were plenty of rumors regarding this year's freebies. Would we get the much lusted after Moto 360 watch? What about a Nexus 8? Well, Google did give attendees a Moto 360 (they'll get them when it comes out later this summer), and everyone will be getting the choice between the LG G Watch and Samsung's Galaxy Gear Live. However, one of the most fun freebies at Google I/O is Cardboard, the origami VR headset that users assemble themselves like a piece of really frustrating IKEA furniture.
Once you do get Cardboard together (and download the dedicated application on the painfully spotty WiFi here in the convention center), the whole package is pretty amazing. You click using a magnetic ring slider on the side, and you go back by tipping the device to portrait mode. There's a few applications to choose from. Google Earth, Street View, and a cute, interactive cartoon world called 'Windy Day' are among them. They vary in quality. One app, Exhibit, just allows you to look at 3D renders of objects from different angles. It's cool, but it's not exactly the VR experience we've been craving since we first tried Oculus Rift. On the flip side, Google Earth or Windy Day are both excellent. Even though Windy Day is a cartoon land, it feels like you're there, and we loved learning about the Palace of Versailles with the touring application. Everyone who tried these apps in the press room was blown away. Below is our own Dan Howley, mesmerized. This was his first VR experience, and he gave it two thumbs up (though he did say it didn't really play nice with his glasses, which will be an issue for anyone who doesn't want to wear contacts).
It's not quite on the same level as Oculus Rift. It's flickery, and because the headset is made of stiff cardboard, it doesn't sit flush against your face, there's light leakage on the sides, and you can sometimes see little bits of real life in your peripheral vision. However, the overall VR effect is there, and you still get that magical feeling that anyone who's tried the likes of Oculus will recognize. The feeling is that this is the future, and it's here now and it's awesome. With general release of Oculus still a ways away, this is an awesome way to spread the VR joy and allow people to try the technology for themselves. Google could easily sell these for $30, and the early adopters would jump right on it, just to see what it's like. Unfortunately, that's unlikely to happen as it's just a 20 percent project that made it to I/O.
Follow Jane McEntegart @JaneMcEntegart. Follow us @tomshardware, on Facebook and on Google+.
dstarr3 26 June 2014 02:30
It's like the Lomo of VR gear.
chintan shah 18 July 2014 05:33
I love the first impression of the product. Just check yourself @ http://www.googlecardboard.com


Helping hundreds of personal trainers all over Australia, we know what your needs are. We work with top of the line equipment that will ensure your clients get the most from their workout and see the results they came to you for.
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This is a concept design based on the requirement for practical blue water cruiser-racer with a raised deck saloon that maintains the sleek clean deck appearance of a Mediterranean day boat. In this case the package comes built into the very latest hull form and appendage set, designed for fast, safe offshore passage making.
True blue water cruiser with a luxurious interior and capable of ocean passages.
Garage for the storage of a permanently inflated rigid inflatable tender.
For the design illustrated we researched where other similar projects had arrived at in layouts and specifications for vessels of this size. Among the datum yachts we reviewed were Visione, Canica, Angels Share, Mystere, Ghost and our own as yet un-announced 45m project. One of the advantages of a modern hull form is the additional volume and usable hull area aft. We've used this to achieve the now familiar 'terrace on the sea' which extends into a protected practical cockpit and stylish aerodynamic coachroof. A working area at the base of the mast blends into the clean looking foredeck with flush glass hatches. There are also 'bomb bay' doors let into the foredeck for storage of some of the working headsails in the dead space between the deck and the crew area.
The layout is an amalgam of our own ideas and what we've seen during our research. The aft 30% of the yacht is left entirely for the exclusive use of the owner and comprises the secluded aft terrace, owner's lounge and stateroom. There is a small guest cabin in this area which would be suitable as a children's cabin or as a dual cabin/office space. Dividing the owner's area from the rest of the yacht is the raised main saloon and lounge. Stepping down from this space and moving forward past two more guest cabins one enters the crew area forward of the mast.
From aft, access into the owners spaces is via the aft deck/terrace through a glazed sliding hatch. Owner's lounge is symmetrical port and starboard with an offset passage way, en-suite guest cabin to port and owner's en-suite with shower and Jacuzzi to starboard. At the forward end of the companionway, step up into the main saloon area.
From the working cockpit companionway step down into the main saloon with 360 degree panoramic views. To port there is a navigation station and lounge area on a raised dias which allows external views while seated. To starboard, a dining area, a couch on the forward bulkhead and access to the machinery spaces under the saloon via the spiral staircase on the aft bulkhead. The raised areas of the saloon, seats and seat backs increase the volume and head height of the machinery space beneath which is 5.5m long and spans the entire width of the yacht.
A short flight of steps (which lift to provide secondary access to the engine room) lead down into the forward half of the yacht with two en-suite guest cabins port and starboard accessed through sliding doors. These are a common feature in the interior of the yacht. The cabins have modular berths allowing configuration as twin or double cabins. A Pullman berth in each increases the capacity of the cabin to three if required. Forward of the mast there is a fully fitted professional galley to port and ships office/utility space to starboard. An alternative (although heavier) arrangement for some owners would be to use this space for a walk in larder. Forward though the companionway watertight door there is a crew mess to port and en-suite captain's cabin to starboard. A passageway leads forward to the remaining crew accommodation, laundry and storage spaces.
The aft lazarette/tender garage, bow thruster compartment/anchor locker and wet stowage area are separated from the main accommodation by watertight bulkheads. Additional storage is provided by lockers that are built into the side decks outboard of the coachroof and the owner's lounge. Access to these are through watertight, teak finished, flush deck hatches.


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New York woman goes overboard on Carnival Ecstasy cruise ship near Bahamas
Carnival Cruise Lines ship Ecstasy (AP Photo/Lynne Sladky)
NASSAU, Bahamas -- The Coast Guard is searching for a woman from upstate New York who reportedly fell overboard from the Carnival Ecstasy cruise ship near the Bahamas Wednesday.
The Coast Guard said 32-year-old Rina Patel of Interlaken was reportedly seen falling overboard around 2:30 a.m. from the 11th deck. The ship was about 27 miles southwest of Freeport, Bahamas.
#BreakingNews #Update 32 YOF reportedly fell overboard at approximately 2:30 a.m. Wednesday. Read more at https://t.co/3CHnYnqorv
— USCGSoutheast (@USCGSoutheast) September 7, 2016
The Coast Guard is searching the area with planes and boats.
A person nearby posted this photo of the Coast Guard searching for the woman:
@FoxNews coast guard looking for girl overboard on carnival ecstasy as of 2:44am pic.twitter.com/ROISgnUB3h
— Shannon Parks (@camconmom) September 7, 2016
Patel was least seen wearing a white dress with a pink floral pattern.
The Carnival Ecstasy's last port of call was in Nassau, Bahamas on Tuesday. Their next port of call is scheduled to be in Charleston, South Carolina on Thursday.
Carnival released this statement:
"Early this morning, a 32-year-old female guest was witnessed jumping overboard from the cruise ship Carnival Ecstasy. The ship was approximately 15 miles off the coast of Grand Bahama island. Man overboard procedures were initiated immediately along with notification to the U.S. Coast Guard. Cruise ship personnel have been participating in the search and rescue operation throughout the morning. At 9 a.m., USCG released the cruise ship to resume its course for Charleston. USCG remains on site to continue the search. The company's CareTeam is providing assistance and support to the missing guest's family on board and our thoughts and prayers are with her and family and loved ones during this difficult time."
Keep checking abc7NY for the latest on this developing story.
coast guardsearch and rescueu.s. & worldcruise ship
Family of Ind. toddler killed in cruise ship fall returns home
Toddler fell through open window on cruise ship: attorney
Ind. toddler dies after fall from cruise ship in Puerto Rico
Search underway for woman who fell off cruise ship


Meet the EDBS Blog Manager & 30-Day Challenge Co-Coach - Eat. Drink & be Skinny!
Hey there – Caitlin here! After working with Eat. Drink & be Skinny for a little while, we wanted to officially introduce myself to you!
For the past year I've been helping out managing the content calendar and more for this blog and also the 30-Day Challenge Series group. As a part of our 2018 goals to bring you better, more timely and actionable content, I'll be stepping up and doing even more. I'm as passionate about helping you live a healthy and happy lifestyle as Teresa and I'm super excited to be contributing even more. As I get to know all of you better, I thought you might to know a little bit more about how I got involved with Eat. Drink & be Skinny and my background in health, fitness and wellness.
I first met Teresa after moving to San Diego in 2015. I was talking to a nice gentleman when I mentioned that I owned a fitness blog. Without a second thought he told me that I had to meet his blogger friend Teresa.
Before I knew it, I was meeting with Teresa regularly to talk about the exciting world of blogging, hang out with her cats, and mooch tasty snacks from her oh so Clean & Colorful Kitchen.
Often times while working together, Teresa would mention that she was going to hire me some day to work for her.
This was so exciting for me! I had always admired Teresa's hard work and dedication to the Eat. Drink & be Skinny community. I was constantly inspired by her new ideas and passion to empower you to make smarter lifestyle decisions and live a healthy and happy life.
Working for Teresa was a no brainer! Shortly before the offer, I made the tough decision to let my blog and resistance band line go. Now I had an outlet for my writing and fitness passion. As the Clean & Colorful Kitchen became busier, I took on more and more tasks until I officially became the Eat. Drink & be Skinny Blog Manager last year.
I now help Teresa keep the blog chugging along full steam ahead and am excited to announce I'll be co-coaching the 30-Day Challenge Series free monthly challenges!
I've been a dancer my entire life – well kind of – since the age of three, and continue to dance today.
I currently live in Minnesota and am on the practice squad for a professional dance team.
I have experience as a personal trainer and group fitness instructor.
I managed my blog, fitGevity, and had my own line of resistance bands for three years.
I love everything fitness and health related!
I'm really good at eating, drinking (mostly coffee) and sometimes being skinny lol.
As I become more involved in creating and sharing ideas here to help you live your best life, I also look forward to mootching more Clean & Colorful snacks, growing with this community, and encouraging more and more people to live a Clean & Colorful lifestyle!


Patricia has helped clients achieve their income and long-term planning goals for more than 30 years in the financial services industry. She has held positions as financial advisor, trust officer and operations manager throughout her career. She joined Wealth Enhancement Group through the 2018 partnership with Retirement Strategies, Inc. Patricia is a Past President of the Jacksonville Alumnae Panhellenic Association and an active member of the Jacksonville Alumnae Group of Kappa Kappa Gamma Fraternity. In her leisure time, she enjoys traveling with her husband, Jay.


text:
UK ISPs are now blocking 93 piracy websites
By James Temperton
StartAgain/Flickr/CC BY-ND 2.0
UK internet providers have been forced to block a further 53 websites, bringing the total number of sites blocked by court orders to 93. The ruling at the High Court is the latest in a series of blocks against torrent websites that link to pirated content.
The Motion Picture Association (MPA), which made the majority of the complaints, said that blocking access to such websites was an "accepted and legitimate measure" to tackle piracy online. "It carefully targets sites whose sole purpose is to make money off the back of other people's content while paying nothing back into the legitimate economy," said Chris Marcich, EMEA president of the MPA.
The High Court ruling orders the UK's five major ISPs to block access to websites that have been deemed to breach copyright. BT was the first to add the latest batch of sites to its block list, with EE, Sky, TalkTalk and Virgin Media all required to follow suit. Smaller ISPs are not required to block the websites.
Sites included in the latest round of blocking include IP Torrents, Isohunt, Sumotorrent, Stream TV, Warez BB and Rapid Moviez. ISPs have been ordered to block piracy websites since 2012 when the High Court ruled that The Pirate Bay be blocked. Since then 92 more websites have been added to the list of
copyright infringers.
The Internet Service Providers Association (ISPA), a trade association for internet services, has once again criticised the blocks as a "relatively blunt tool". In the past the ISPA has said that the industry should focus on creating better legal services, rather than pursuing blocks against online copyright infringement.
Critics of the blocks have also pointed out that they are relatively easy to bypass. With more piracy websites appearing everyday copyright holders face an uphill battle to block the latest offenders.
The UK will block online porn from July 15
By Matt Burgess
Porn websites are totally confused about the UK's porn block plans
Monday briefing: India fails to soft-land Vikram on the Moon
What Google's Huawei ban means for millions of Android owners
By Andrew Williams


text:
Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus: A global perspective
P. Zimmet, R. L. Kirk, S. W. Serjeantson, H. King
Refinement of the classification of diabetes mellitus to include two major categories, insulin dependent (IDDM) and noninsulin-dependent (NIDDM) and the recent attention paid to the standardization of epidemiological techniques have led to much new information on the epidemiology of the disease. Support for the notion of genetic influence in the development of NIDDM has come from twin studies, but the search for specific genetic markers for NIDDM has been largely unproductive to date. There is increasing scepticism as to the utility of the chlorpropamide-alcohol flush as genetic marker for NIDDM. The large disparity in the frequency of NIDDM between populations provides indirect support for the genetic hypothesis, as do recent studies of the association between NIDDM and ancestral genetic admixture. Obesity has long been considered a causal factor in the aetiology of NIDDM, though the strength and consistency of this relationship is now being questioned. The strength of the association between obesity and NIDDM has been shown to vary depending on the presence or absence of a family history of the disease. There is further preliminary evidence to suggest that association between obesity and NIDDM may vary in strength between populations, and between the sexes. Little evidence has so far emerged for a role of quantitative or qualitative aspects of diet in the aetiology of NIDDM. This may be due, in part, to the imprecision of current techniques for dietary estimation. The role of physical inactivity in the genesis of NIDDM is gaining increasing support from some diabetologists, but, once again, studies are hindered by the lack of objective and reliable measurement procedures. Other 'environmental' factors which may be associated with NIDDM include socio-economic status, parity and psychosocial stress. Analytic epidemiology is playing a growing role in the elucidation of the genetic and environmental determinants of NIDDM. As the science of public health, epidemiology may provide a framework for the eventual prevention of this common and debilitating disease.
Annals of the Academy of Medicine Singapore
Zimmet, P., Kirk, R. L., Serjeantson, S. W., & King, H. (1985). Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus: A global perspective. Annals of the Academy of Medicine Singapore, 14(2), 347-353.
Zimmet, P. ; Kirk, R. L. ; Serjeantson, S. W. ; King, H. / Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus : A global perspective. In: Annals of the Academy of Medicine Singapore. 1985 ; Vol. 14, No. 2. pp. 347-353.
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title = "Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus: A global perspective",
abstract = "Refinement of the classification of diabetes mellitus to include two major categories, insulin dependent (IDDM) and noninsulin-dependent (NIDDM) and the recent attention paid to the standardization of epidemiological techniques have led to much new information on the epidemiology of the disease. Support for the notion of genetic influence in the development of NIDDM has come from twin studies, but the search for specific genetic markers for NIDDM has been largely unproductive to date. There is increasing scepticism as to the utility of the chlorpropamide-alcohol flush as genetic marker for NIDDM. The large disparity in the frequency of NIDDM between populations provides indirect support for the genetic hypothesis, as do recent studies of the association between NIDDM and ancestral genetic admixture. Obesity has long been considered a causal factor in the aetiology of NIDDM, though the strength and consistency of this relationship is now being questioned. The strength of the association between obesity and NIDDM has been shown to vary depending on the presence or absence of a family history of the disease. There is further preliminary evidence to suggest that association between obesity and NIDDM may vary in strength between populations, and between the sexes. Little evidence has so far emerged for a role of quantitative or qualitative aspects of diet in the aetiology of NIDDM. This may be due, in part, to the imprecision of current techniques for dietary estimation. The role of physical inactivity in the genesis of NIDDM is gaining increasing support from some diabetologists, but, once again, studies are hindered by the lack of objective and reliable measurement procedures. Other 'environmental' factors which may be associated with NIDDM include socio-economic status, parity and psychosocial stress. Analytic epidemiology is playing a growing role in the elucidation of the genetic and environmental determinants of NIDDM. As the science of public health, epidemiology may provide a framework for the eventual prevention of this common and debilitating disease.",
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Zimmet, P, Kirk, RL, Serjeantson, SW & King, H 1985, 'Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus: A global perspective', Annals of the Academy of Medicine Singapore, vol. 14, no. 2, pp. 347-353.
Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus : A global perspective. / Zimmet, P.; Kirk, R. L.; Serjeantson, S. W.; King, H.
In: Annals of the Academy of Medicine Singapore, Vol. 14, No. 2, 1985, p. 347-353.
T1 - Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus
T2 - A global perspective
AU - Zimmet, P.
AU - Kirk, R. L.
AU - Serjeantson, S. W.
AU - King, H.
N2 - Refinement of the classification of diabetes mellitus to include two major categories, insulin dependent (IDDM) and noninsulin-dependent (NIDDM) and the recent attention paid to the standardization of epidemiological techniques have led to much new information on the epidemiology of the disease. Support for the notion of genetic influence in the development of NIDDM has come from twin studies, but the search for specific genetic markers for NIDDM has been largely unproductive to date. There is increasing scepticism as to the utility of the chlorpropamide-alcohol flush as genetic marker for NIDDM. The large disparity in the frequency of NIDDM between populations provides indirect support for the genetic hypothesis, as do recent studies of the association between NIDDM and ancestral genetic admixture. Obesity has long been considered a causal factor in the aetiology of NIDDM, though the strength and consistency of this relationship is now being questioned. The strength of the association between obesity and NIDDM has been shown to vary depending on the presence or absence of a family history of the disease. There is further preliminary evidence to suggest that association between obesity and NIDDM may vary in strength between populations, and between the sexes. Little evidence has so far emerged for a role of quantitative or qualitative aspects of diet in the aetiology of NIDDM. This may be due, in part, to the imprecision of current techniques for dietary estimation. The role of physical inactivity in the genesis of NIDDM is gaining increasing support from some diabetologists, but, once again, studies are hindered by the lack of objective and reliable measurement procedures. Other 'environmental' factors which may be associated with NIDDM include socio-economic status, parity and psychosocial stress. Analytic epidemiology is playing a growing role in the elucidation of the genetic and environmental determinants of NIDDM. As the science of public health, epidemiology may provide a framework for the eventual prevention of this common and debilitating disease.
AB - Refinement of the classification of diabetes mellitus to include two major categories, insulin dependent (IDDM) and noninsulin-dependent (NIDDM) and the recent attention paid to the standardization of epidemiological techniques have led to much new information on the epidemiology of the disease. Support for the notion of genetic influence in the development of NIDDM has come from twin studies, but the search for specific genetic markers for NIDDM has been largely unproductive to date. There is increasing scepticism as to the utility of the chlorpropamide-alcohol flush as genetic marker for NIDDM. The large disparity in the frequency of NIDDM between populations provides indirect support for the genetic hypothesis, as do recent studies of the association between NIDDM and ancestral genetic admixture. Obesity has long been considered a causal factor in the aetiology of NIDDM, though the strength and consistency of this relationship is now being questioned. The strength of the association between obesity and NIDDM has been shown to vary depending on the presence or absence of a family history of the disease. There is further preliminary evidence to suggest that association between obesity and NIDDM may vary in strength between populations, and between the sexes. Little evidence has so far emerged for a role of quantitative or qualitative aspects of diet in the aetiology of NIDDM. This may be due, in part, to the imprecision of current techniques for dietary estimation. The role of physical inactivity in the genesis of NIDDM is gaining increasing support from some diabetologists, but, once again, studies are hindered by the lack of objective and reliable measurement procedures. Other 'environmental' factors which may be associated with NIDDM include socio-economic status, parity and psychosocial stress. Analytic epidemiology is playing a growing role in the elucidation of the genetic and environmental determinants of NIDDM. As the science of public health, epidemiology may provide a framework for the eventual prevention of this common and debilitating disease.
JO - Annals of the Academy of Medicine Singapore
JF - Annals of the Academy of Medicine Singapore
Zimmet P, Kirk RL, Serjeantson SW, King H. Genetic and environmental influence in the epidemiology of noninsulin-dependent diabetes mellitus: A global perspective. Annals of the Academy of Medicine Singapore. 1985;14(2):347-353.


text:
7-Deaza-8-aza-dG-CE Phosphoramidite (PPG)
5'-Dimethoxytrityl-N-dimethylformamidine-8-aza-7-deaza-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Several products may be used to investigate the effect on the activity of an oligonucleotide when key structural elements are changed. The 7-deaza purine monomers lack groups critical for hydrogen bonding. 7-Deaza-8-aza-A and 7-deaza-8-aza-G (PPG) monomers are isomers of A and G and have similar electron density. Their presence in oligos is slightly stabilizing relative to A and G. Unlike G, PPG does not lead to aggregation and G-rich oligos can be easily prepared and isolated. 5'-Fluorescein oligos with PPG at the 5'-terminus are much less quenched than the equivalent G oligos. As a purine analogue of Thymidine, 7-deaza-2'-deoxyXanthosine (7-deaza-dX) promises to have interesting effects on DNA structure of triplexes. 7-Deaza-dX also forms a non-standard base pair with a 2,4-diaminopyrimidine nucleoside analogue. Standard nucleobases have an unshared pair of electrons that project into the minor groove of duplex DNA. Enzymes that interact with DNA, polymerases, reverse transcriptases, restriction enzymes, etc., may use a hydrogen bond donating group to contact the hydrogen bond acceptor in the minor groove. 3-Deaza-2'-deoxyadenosine is very interesting in that it maintains the ability for regular Watson-Crick hydrogen bonding to T but is lacking the electron pair at the 3-position normally provided by N3.
This product is for research purposes only, and may not be used for commercial, clinical, diagnostic or any other use. The Product is subject to proprietary rights of ELITechGroup and is made and sold under license from ELITechGroup. There is no implied license for commercial use with respect to this Product and a license must be obtained directly from ELITechGroup. with respect to any proposed commercial use of this Product. "Commercial use" includes but is not limited to the sale, lease, license or other transfer of the Product or any material derived or produced from it, the sale, lease, license or other grant of rights to use the Product or any material derived or produced from it, or the use of the Product to perform services for a fee for third parties (including contract research). AquaPhluor®, Yakima Yellow®, Redmond Red® and Eclipse® are registered trademarks of ELITechGroup.
10-1073-02 0.25 g .25grams 3.03 87.67 52.6 32.88 23.91 17.53 4.38
10-1073-95 50 µmol .041grams 0.5 3.33 2 1.25 0.91 0.67 0.17
10-1073-02 0.25 g .25grams 4.52 0.07 84 52.5 38.18 5.25
10-1073-95 50 µmol .041grams 0.75 0.07 8.6 5.38 3.91 0.54
REFERENCE(S)| 1 I.V. Kutyavin, et al., Nucleic Acids Res., 2002, 30, 4952-4959.
7-Deaza-dA-CE Phosphoramidite
7-deaza-dG-CE Phosphoramidite
7-deaza-8-aza-dA-CE Phosphoramidite


Looking for Custom Shower Doors in Desert Palms? We have exemplary workmanship and the finest of products.
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Westhall Manor
Directly opposite the bungalow where I live is West Hall Road. When I first moved here it was possible to walk to the end of that road and take a footpath past the Albert Victor Public House onto Manor Road. Modern bungalows now occupy the land where the footpath ran and the Albert Victor is a private dwelling well screened from the road. However the old house of the Manor of Westhall is still standing at right angles to the road more than 330 years after it was built. Its surroundings have changed enormously of course in that time and the old house is not the way it was but at least it still stands witness to the village's past.
The Lordship of Westhall, as with others in the village, goes back to the time of the Conqueror. At one time a family called Deorsige held these lands. The name of our village can be broken up into Deorsige + ingas + ham translating as "Homestead of Deorsige's people". Another explanation of the name, which is given in some accounts, is Der (water) + ing (meadow) + ham (dwelling) translating to "Dwelling by the water meadow". Personally I like the poetry of the latter version. In the Domesday Book the name is spelt Dersincham.
In about 1303 one Sir Robert Tateshall held the lands "in capite", that is directly from King Edward 1 (1272-1307).
Documents describe Sir Robert as holding "one fee" which the Prior of Binham held from him. A knight's fee was a feudal estate normally worth £40 or more. Just two years later a member of the Pakenham family is recorded as holding some of the lands. During the reign of Henry V111 (1509-47) the Manor was held by Sir Thomas Paston who had also acquired other lands in the village as a result of the dissolution of the monasteries. I have no information of how the lands were disposed after this time until the Cobbe's of Sandringham acquired them in about 1646. The Cobbe's have appeared before in these accounts as they had also acquired the lands of Pakenham Manor, Binham Priory Manor and Gelham Manor. They were a Catholic family who sided with the King in the English Civil War and as a consequence their lands were sequestered by Parliament. Although they regained their property later their fortune never really recovered and their estates were sold to the Hoste family in 1686. However, all references I have found to the Manor House give 1671 as the date of its construction when it was still part of the Cobbe's estate.
The year 1671 was a very significant for the village; it was the year of the great flood and battles against the waves were a common feature of life on the East Coast. In late August and early September of 1671 there was a period of extremely stormy weather. It reached a peak on or around September 12th and the whole countryside around Lynn was inundated. The tide rose so high it swept over all sea banks and every able-bodied person would have been summoned to the fight against the sea, and to save what livestock and property they could. Winter fodder was ruined, livestock perished, coastal roads destroyed, and many ships were wrecked in the Wash. The event is recorded in Dersingham's parish register. "September the 12th 1671. The fflood was on the twelfe day of September in the year of our Lord one thousand six hundred and seaventye and one. All the generall marshes in Dersingham and also the common marshe there were overflowed by reason that the tyde did come over all the banks first and after made severall breaches of the said bankes. The like was also knowne by the space of fifty or as some say sixty years before..severalle cattell were lost in the Common Marsh there." Water entered many cottages but fortunately there was no loss of human life. The mention of a previous flood that occurred sixty years earlier tallies with an account of a historian called Dugdale. In 1613 he wrote of a storm that battered Norfolk Marshland. "A dreadful inundation of the sea on the 13th November…….A bridge was shattered, over 2000 head of livestock drowned, 480 acres of land sown with corn were swamped and 13 houses ruined." I mention these floods because the Cobbes owned not only Westhall Manor but also Gelham Manor. Gelham Manor Hall used to stand on the Marsh side of the village down The Drift almost opposite the present West Hall Manor House. If Gelham Manor House were still standing in the 17th century it would surely have been badly affected by these great floods and any in previous years especially as the waters of the Wash then approached much nearer to the village. So was this the time when the decision to abandon that house was finally taken and a new Manor House of Westhall built at a safer distance from the fury of the Wash? This is only conjecture; I have no historical evidence to prove or disprove the theory. 1671 also marked the building of the Tithe barn and the Hall opposite.
Fifteen years later, in 1686, the Manor of Westhall passed to the Hoste family as part of the Sandringham Estate. Armstrong's History states that in about 1780 Dixon Hoste was the Lord of the Manor. Dixon, the grandson of James Hoste of Sandringham, lived at Ingoldisthorpe Hall. He lost much of his fortune in supporting the political ambitions of Coke of Holkham and was finally forced to sell the house at Ingoldisthorpe and the estate. At some point the house in Manor Road was administered by the village council. There are several references in the early 18th century to the village Town House. In 1754 an overseer John Doyle did work on the Town House and there is a bill dated 1754 for "2 days work of thatching on the Town House by order of Mr. Doyle…..3s. 6d." The suggestion is made that this Town House was Westhall Manor. Certainly on Bryant's map of 1826 it is clearly marked as a Workhouse.
Various Acts of Parliament had made the Parish the administrative unit for the relief of the poor. Parishes were encouraged to establish workhouses where the poor could be set to work. Then in 1834 the Poor Law Amendment Act was passed and a central authority was set up. This led to the establishment of the new Poor Law Unions when larger workhouses were established. In this area one was built just outside Docking and another in King's Lynn. The smaller Parish workhouses became redundant and were often sold. The inmates in Dersingham were transferred to the Docking Union Workhouse.
The Tithe Map of 1839 reveals that one Elizabeth Rouse was now the owner of the land and cottages in the area. At some time the old house had been divided into three separate cottages with further houses added on. Although the identifying numbers on the map are difficult to read it would appear that Moses Grimes and others unnamed occupied these cottages that once formed the Manor House. Moses Grimes is listed in the 1851 census, age 74 an agricultural labourer with Fanny Wales as his housekeeper. His neighbours were John Green, John Flegg, wheelwright, William Flegg and William Daw, a fisherman.
In the twentieth century villagers recall the area about the Manor and The Albert Victor being called Laundry Yard. Several villagers recall seeing the steam rising from the roof of the washhouse as they passed on their way to school. A dyke with flowing water once ran down from Doddshill, along Manor Road, down The Drift and thus to the sea. On Mondays water was taken from the stream to fill the coppers and heat for the washing. A chore that took up most of the day. Before Mains water was laid on the villagers fetched their water from wells one of which was behind the Albert Victor. Opposite was a Blacksmith who frequently had an audience of children dawdling to and from school. So the area about the old house has always been one of constant bustle.
It was in 1966 that Mr. S. C. Turner bought two of the cottages that were once part of the old Manor and re-converted them into a single dwelling. The sympathetic alterations have restored the character and charm of this old house, but it still has many secrets to give up.
On the 11th August 1880 the following announcement, which is relevant to the Dersingham Manors, appeared in the Lynn Advertiser:
"The General Courts Baron of his Royal Highness the Prince of Wales for the undermentioned Manors will be held as follows, (namely) For the several Manors of West Newton, Buckenhams with Appleton, and West Newton Rivetts on Thursday the 26th day of August instant at 12 o'clock at noon at the house of Mr. Sherrington in West Newton. For the several Manors of Shouldham in Darsingham and Brookhall in Darsingham on the same day at 1o'clock in the afternoon at The Cock Inn Dersingham. Of which all persons concerned are requested to take notice and attend accordingly, and pay their Quit Rents and perform their suits and services.
L.W.Jarvis Steward."
The Cock Inn is now The Feathers.
A quit rent was a single annual payment to be offered in lieu of ancient goods and services.


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Make great use of the key limes you have with this simple, classic pie recipe.
One of the most popular pies to find on the menu is the infamous key lime pie. As the name suggests, this pie features a key lime-flavored cream filling held on top of a crumb crust and topped with whipped cream. Key lime pie is also one of the simplest recipes to prepare especially on a first try.
Some might already be asking the age-old question when coming across recipes with "key lime" in the name: What separates them from regular limes? Well, that is determined by some subtle differences.
Key limes are a little smaller than regular limes but they pack a harder punch when it comes to flavor. However, they might be a little hard to track down at the grocery store than regular limes. The latter, also known as Persian limes, are usually preferred for their size and lack of seeds which is why key limes are overlooked sometimes.
This recipe for key lime pie is as simple as it gets. Things start with a simple graham cracker crust straight from a cheesecake recipe, followed by the filling and ends with a topping of Creme Chantilly (aka whipped cream).
All three components are simple to make especially the filling. Though not universal, a basic formula for the filling can consist of a 2:1:1/2 ratio of sweetened condensed milk to key lime juice to sour cream (or cream cheese in some variations). The following recipe is pretty much what was outlined but with minor adjustments.
Preheat an oven to 350°F. Melt the butter in a small saucepan or frying pan over low heat. Set aside.
To make the crust, break the graham crackers and put in a food processor. Add the sugar. Process until the dry mixture is fine. Pour the melted butter into the mixture as it processes to combine. Fill the bottom of a 9-inch pie pan with the crust mix and use the back of a spoon to level it.
To make the filling, whisk together the sweetened condensed milk, key lime juice, lime zest in a bowl. Stir in the sour cream.
Pour the filling into the crust-lined pan and use a rubber spatula to smooth the surface.
Bake the pie for 10-15 minutes. Remove to cool, then chill in the refrigerator for 3 hours or more before serving.
When it's time to serve, prepare the Creme Chantilly by beating the heavy cream with an electric mixer until it forms soft peaks. Add the powdered sugar and vanilla extract, then continue beating until the whipped cream forms stiff peaks. Glaze the pie with the Creme Chantilly by spreading it or piping it decoratively on top. Serve.


6 Hour Behind the Wheel Instruction is required anytime you get your permit before turning 15 1/2 or take the Classroom Course. We divide the 6 hours of instruction into 3- 2 hour sessions. We also provide the training vehicle.
Behind the Wheel Instruction consists of city, residential, mountain, highway and county driving. We also teach parallel, perpendicular and angle parking. Three point turns, U-turns and various other driveway turnarounds are also taught. We also go over lane changes, left and right turns, backing and steering with students. Legal stopping points, right of way, and visual search patterns will be taught in an attempt to make your student an aware safe driver.
Drive sessions are only allowed to be booked within 15 days of each other. This is to encourage and give the student time to practice what was learned in between sessions.
6 Hour Behind the Wheel Instruction is offered with our Classroom Course, Home Study Course and Online Course. We also offer just the 6 Hour Behind the Wheel Instruction needed for teens to obtain a drivers license.


More typing today on that world wide web thing about 2012 presidential candidates skipping Iowa's Republican Party Caucuses. Marc Ambinder's thoughts are here. Craig Robinson of The Iowa Republican posts his thoughts here. Last week, Tom Beaumont of The Des Moines Register fueled the "Romney will skip Iowa in 2012" speculation with this story, quoting Dave Kochel, a 2008 Romneyack. (I just made that word up; it sounds fun to SAY it but looks weird to TYPE it. Maybe we'll go with Romneyite?) Kochel, anyway, is well known within Iowa political circles. He was a key consultant to Romney for the run up to '08. Romney, you may recall, didn't "skip" the Iowa GOP Straw Poll in Ames in August of 2007 like Straw Poll skippers John McCain and Rudy Guiliani did.
And can we really go so far as to say McCain "skipped" Iowa entirely in the last cycle? He certainly spent a lot of time and money in the state in the first part of 2007. But then the wheels fell off his national campaign, he jettisoned staff and flew commercial for the rest of '07. He came back to Iowa in July of 2007 and made some line-in-the-sand statements about the campaign not dying, but living on, albeit more frugally, and McCain predicted (on that day — July 22, 2007) that he'd win the Iowa Caucuses. He went to the 2007 Iowa State Fair. He participated in a candidate debate here in early August. During a campaign stop in Ankeny on August 4, McCain ridiculed the "EarthPark" project for which Republican Senator Chuck Grassley had secured federal funding, calling it "EarthPork" instead. And then McCain spent Labor Day 2007 in Iowa.
In October of 2007, McCain came back to campaign in Iowa and made an appearance on "Iowa Press." McCain returned to Iowa in early November to tout Kansas Senator Sam Brownback's endorsement.
In the closing week of the Iowa Caucus campaign McCain made a whirlwind tour of Iowa. It was December 27, 2007 — just days before the January 3, 2008 Caucuses.
So, looking at that array of campaign visits, we see after McCain's campaign "tanked" in July, 2007, and he was widely said to have "focused all his energies on New Hampshire," McCain still made campaign visits to Iowa in August, September, October, November and December. He was not in Iowa on January 3, 2008, to thank all those Iowa McCainers who helped him secure a fourth place finish, right behind his old buddy Fred Thompson, but McCain had been here at least once every month in the last half of 2007. Does that seem like a "skip Iowa" strategy to you?


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Bohemian Pants donates 10% of net profit to help protect Nature.
The Nature Conservancy has a vision of a world where the diversity of life thrives, and where everyone acts to conserve nature for its own sake and ours. They have a very diversified staff, including more than 600 scientists, all of whom impact conservation in 69 countries. They value ethics and thrive to have professional standards in all of their organizational endeavors and, in doing so, hold themselves accountable to their mission and to the public. They recognize that conservation is best advanced by the leadership and contributions of men and women of diverse backgrounds, beliefs and cultures. They recruit and mentor staff to create an inclusive organization that reflects their global character.
Sierra Club was one of the first large-scale environmental preservation organizations in the world, and presently takes part in campaigning lawmakers to advance green approaches. As of late, the club has inclined toward green legislative issues and especially toward bright green environmentalism. Recent focuses of the club incorporate advancing environmentally friendly power vitality, moderating a worldwide temperature change, and restricting coal.
Environmental Defense Fund is one of the world's largest environmental organizations, with more than 1.5 million members and a staff of 550 scientists, economists, policy experts, and other professionals around the world. They work on issues related to global warming, oceans and general ecosystem restoration. EDF aims to reduce the pollution and global warming, with strategies including overhauling U.S. energy systems, protecting the United States Environmental Protection Agency's limits on pollution, training new climate/energy leaders, and slowing deforestation in the Amazon rainforest. Please help support these amazing organizations by donating directly to them or by purchasing a pair of our Bohemian Pants.


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"We had a very positive experience with Tuohy Law Offices when planning our estate. Tom is a great attorney, comprehensive, professional, patient, and caring. His staff could not be more helpful and friendly while planning our visit and following up afterward. We feel very fortunate to have been referred to Tuohy Law Offices and confident that we will be able to use this office for all our future legal needs. " –David and Marie Chimino
About Tuohy Law Offices
The Better Business Bureau has awarded Tuohy Law Offices its highest assessment of A+. We are in an ideal location and beautiful office space. Located at 17W220 22nd St, Suite 300, Oakbrook Terrace, IL 60181 in the beautiful Oakbrook Terrace Atrium Building. Our office features an open kitchen and workspace and window line offices adjacent to the Oakbrook Center Mall and numerous retail outlets and restaurants. After your visit, enjoy lunch or dinner at Gibsons, Ditka's, Seasons 52, and Giordano's. Covered and outdoor parking is free in the building.
This is a law office that comes in early and stays late. Above all, our objective is simple: work as hard as our clients do and deliver the results they deserve.
Respect is a word that we apply to our clients. You have earned our respect, and we will work hard to earn yours. This is a service business. Our client is our number one concern.
The standard operating procedure for Tuohy Law Offices is to be understandable, professional, and personable.
15,000 clients have found this office to answer the question: How do you find a good lawyer? Connect with us and learn more.
About Tom Tuohy
"Our experience with Tom Tuohy was five stars; from the moment that we walked into his office and meeting his staff and then talking to Tom, it felt like we were with friends. My wife and I wanted to get our estate planning done for many years, and we were happy that we found Tuohy Law to have it completed finally. Thank You." –George Zaccagnini
Tom Tuohy served as Special Assistant Attorney General of Illinois from 1984 to 1986. Mr. Tuohy founded his Chicago law firm in 1982, now known as Tuohy Law Offices. Most Importantly, the firm provides educational seminars and legal services in estate planning, preserving personal assets, and financial security. Further, Mr. Tuohy also established the Fraternal Order of Police Legal Benefits Plan. He has represented countless numbers of police officers, from rank and file to police superintendents.
Meet Tom Tuohy, Chicago Attorney
Over the past 38 years, Tom Tuohy has represented more than 15,000 individuals in the greater Chicago-land area, Illinois, and country. He is respected for his ability and willingness to inform the public of the legal issues affecting their lives. Additionally, Mr. Tuohy provides legal education seminars to the City of Chicago and Chicago Police Department employees for 31 years. He also represents members of major labor unions such as the International Brotherhood of Electrical Workers, US Steelworkers, Fraternal Order of Police. Additionally he represents Metra, Chicago Transit Authority, and Secretary of State of Illinois employees and residents of communities across Illinois.
It is our goal to be welcomed into client's families as trusted advisors and friends. Above all, giving back to the community and the next generation and working hard to earn clients' respect. We believe that is what it means to be a lawyer.
The Illinois lawyers affiliated with Tuohy Law Offices are a network of the highest-rated and most experienced national and local attorneys. The attorneys concentrate in Catastrophic Personal Injury, Malpractice, Products Liability, Wrongful Death, and Workers Compensation, Nursing Home Abuse and Neglect, Estate Planning, Living Trusts, and Small Business.
Learn more about our practice offerings.
Comprehensive Benefits of America, LLC
In 2015, Mr. Tuohy founded the Comprehensive Benefits Plan of America, LLC, which levels the playing field for middle-class Americans and gig economy employees by providing them with essential financial wellness benefits.
Dreams for Kids and Community Work
Chicago Attorney: Making a Difference in the Lives of Others Through Non-Profit, Dreams for Kids.
The founder of Dreams for Kids, Mr. Tuohy, is also a founding board member of the Jesse White Tumbling Team. He is a founding board member of DePaul University's Mentor Advisory Program and Chicago's New Media Council and served on the Partnership Board of Avenues to Independence. Tom is a global delegate to KIN Global (Kellogg Innovation Network) and a former member of the Chicago Council on Global Affairs.
A graduate of DePaul University, Mr. Tuohy received his Juris Doctorate from DePaul Law School. He is a Northwestern University Kellogg School of Business alumnus as an Executive Scholar and was awarded a Fellowship to attend Stanford Business School to study Social Innovation.
In 2015, Mr. Tuohy was selected as a member of the Nations Top One Percent by the National Association of Distinguished Counsel, which recognizes attorneys who elevate the Bar's standards and provide a benchmark for other attorneys to emulate. His selection as one of the top 1% of all attorneys in the United States was vetted by a blue-ribbon panel's independent research and approved by a judicial review board. Mr.Tuohy has also been awarded the Prestigious Highest Rating (AV) for Legal Skill and Competence for 14 consecutive years by the premier attorney rating service of Martindale Hubbell. In addition, AVVO has awarded Mr. Tuohy the highest rating of Superb 10/10. Finally, he has received numerous community awards and recognition as one of Illinois' and of the United States' most respected attorneys.
Read Tom Tuohy's Full Biography Here
Visit Tom's Personal Site For More Information Here.
Tuohy Law Offices is a convenient and easy to access location, right off the 22nd St exit of Route 88/294. Park for free, stay for lunch, and do some shopping!
We are looking forward to seeing more of you, your family, and your friends. Even if you do not have any business to take care of, stop by our Oakbrook Terrace office for some coffee and say Hi!


What's keeping expat HRDs in the banking sector?
Despite recent government efforts to employ more locals in Singapore, there are still a large number of foreign executives, especially in HR, working in the banking industry. Why has this group chosen to stay? One reason stands out from the rest: maids.
Financial services careers website, eFinancialCareers, spoke to a number of foreign PMEs in Singapore who said their domestic workers made their lives "immeasurably easier" than they would have been back home.
As of 2015, there were over 220,000 foreign domestic workers (FDWs) in Singapore. With the average wage being around S$500 per month, the cost of a home helper is well worth it with regards to the benefits provided (even including additional expenses such as insurance and agency fees).
A better work/life balance was one advantage mentioned with many foreign executives experiencing more time to spend with their families or on their hobbies. Comparisons were inevitably made between Singapore and life back in their home countries.
"In the UK you plan an evening out months in advance – arrange a babysitter, pay for super expensive taxis and make sure you're back on time," Kyle Blockley, managing partner of recruitment firm KS Consulting in Singapore, told eFinancialCareers.
Emma Boyd, managing director of data company Bright Tiger in Singapore, said that maids were very helpful for working mothers.
"I knew a couple of senior bankers who would have their helper bring their baby to work so they could breast feed and collect pumped milk," she said.
Properly managing the helper/employer relationship is especially important. In HR's case however, this should come naturally as the same skills and strategies used to direct staff in the office can also be used to benefit from and work with FDWs at home.


The techniques used for cleaning a laptop LCD screen, whether it's for a desktop or laptop computer, are filled with controversy! Generally, no one recommends using any liquids because they can damage the LCD's delicate surface. Even so, you've gotta have something to rub with if you ever plan on getting that sneeze residue off the thing!
For general cleaning, get a soft, lint-free cloth.
Use it to wipe the dust off the monitor.
Dampen a sponge or lint-free cloth with water.
Be sure to wring out all the excess moisture. Rub the screen's surface gently, and don't get any excess liquid on or inside the monitor.
Office-supply stores carry special LCD screen cleaners as well as the lint-free wipes that you can use to clean your screen and the rest of your laptop.
One product that is recommended is Klear Screen, from Meridrew Enterprises (www.klearscreen.com). No, it's not cheap. You want good, not cheap.
Avoid using alcohol or ammonia-based cleaners on your laptop screen! They can damage the LCD screen.


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The Roots Reach a Crossroads: August 29 in Hip-Hop History
On this day, we celebrate Michael Jackson's birthday and remember albums by the Roots, Daz Dillinger, Junior M.A.F.I.A. and DJ Clue?
20 Rappers That Were Influenced by the Native Tongue Movement
How many hip-hop collectives can you say started a movement that's still being followed 30 years later?
Daryl Nelson
20 Great Hip-Hop/Jazz Albums of the '90s
Musician Wynton Marsalis may not like rap, but jazz and hip-hop have been synonymous with each other since the 1990s.
20 Classic Hip-Hop Summer Love Songs
These classics are the perfect jams for your summer luvin'.
Preezy
The Greatest Band in the Land Rocks the Greatest Music Festival
The Roots did not disappoint at Essence Festival.
Naima Cochrane
July 13 in Hip-Hop History: Gerald Levert, Run-DMC + More
On this date in hip-hop history, we remember the late Gerald Levert, salute Run-DMC's Live Aid moment and 'tip' our hats to the Roots.
Roots Picnic Cut Short Due to Severe Weather, Dipset Performs
The Roots Picnic ended abruptly due to inclement weather, but Dipset and Fabolous did rocked the mic.
Erykah Badu, The Roots & More Headline Smokin' Grooves Fest 2018
Music superstars Erykah Badu, the Roots and more are set to rock the Smokin' Grooves Fest in June.