Liebherr Maritime Cranes launches the game-changing technology SmartGrip for its mobile harbour crane product range. This unique technology operates as an intelligent system which optimises grab filling rates in a self-learning manner. SmartGrip provides a number of valuable advantages, including higher performance and zero overloads.
Two Liebherr portal cranes (LPS 600) operating in the port of Polnocny.
The development of SmartGrip is based on recent turnover analyses in various ports around the world. The data showed that, on average, only 70% of the grab capacity is used. There are many factors why the grab is not operated at full capacity, including suboptimal grabbing angle and varying material density. For crane operators the estimation of the material density and the right grabbing angle may turn out to be a real challenge. As a result, ports are faced with less turnover [t/h] than expected.
SmartGrip is the solution to optimise grab filling rates. In a comprehensive field study, Liebherr collected real data of different crane models which were equipped with a wide range of grabs to handle different materials. Additionally, numerous crane operators ensured a broad spectrum of skill-levels during data collection. Thanks to in-depth analyses, Liebherr has deduced the ideal grab filling model by means of data mining. In operation, the self-learning system automatically adjusts its behaviour by recognizing bulk density, compression and granularity as well as current frame conditions like depth of impression or type of grab. Load cycle by load cycle, SmartGrip automatically optimizes filling to maximum capability taking grab size and outreach into account. Right from the second load cycle, SmartGrip ensures that the grab filling rate is above the average of 70%. Within a maximum of seven cycles the full capacity of the grab is utilized.
Changing materials and varying density are main challenges for the crane operator in bulk operation. Furthermore, density also depends on depth of impression which means that even when working on the same hatch, handling situation may change. If the driver needs to fill the grab manually, he may overload the crane when pulling the lifting attachment out of sticky material. Frequent overloads lead to a notably shorter lifetime of the crane. Additionally, frequent overloads are also time-consuming as the crane is automatically switched off if there is too much pull on the grab. SmartGrip controls the filling of the grab to suit the load curve of the crane. This leads to perfect crane utilization without overloading. Thus, SmartGrip also works as overload prevention system resulting in an extended lifetime of the crane, saving fuel and time.
Bulk material handling comprises a number of challenges. To maximise productivity, the grab has to be filled to the limit, which means the driver has to fine-tune grab filling by opening and closing the grab as well as hoisting and lowering. This is both stress for the operator and time-consuming.
When SmartGrip is activated, the operator can completely rely on the system for an accurate determination of the material density and optimal grabbing angle in a very short time. The automatic and optimized grab filling means less stress for the crane operator who can then focus more on other important issues like safety.
Achieved turnover depends on many issues, including available infrastructure, driver skills and materials handled. SmartGrip optimises various parameters and allows for improved performance. In view of the average grab filling rate of 70%, SmartGrip offers a potential of up to 30% more turnover. Additionally, turnover variance is significantly reduced, leading to more efficiency in operation. Field studies showed that even up to 40% turnover increase are realistic if the grab filling rate is below average. Additionally, SmartGrip partly closes the gap between high-skilled and less-skilled drivers, as some important parts of bulk handling are automatically optimised by the system.
To achieve substantial turnover increase the whole logistic chain needs to be considered. Liebherr supports its customers by offering detailed process analysis of the existing material handling infrastructure in order to harmonise transportation chains and to maximise efficiency.
Another striking feature offered by SmartGrip is the possibility to manually set target loads. If a crane operator needs to load a 40 tonnes capacity truck, for instance, he can advise SmartGrip to fill the grab with 40 tonnes. This feature eases the operation of the crane operator.
Many bulk terminals handle different types of bulk cargo and each material comes with unique characteristics. In order to ensure efficient operation a range of grabs is necessary. However, the more grabs are needed the higher the costs. This includes acquisition costs, time needed to exchange the lifting attachment and storage space required. Due to intelligent grabbing, the number of necessary grabs is significantly reduced as the system automatically adapts the grab filling rate to the material handled and the size of the grab. Thereby the number of required grabs can be reduced without losing performance.
Operators of older Liebherr machines can equip their existing cranes with this unique feature for more bulk turnover. The installation of SmartGrip is fast and easy.
With the introduction of SmartGrip, Liebherr successfully continues its path of innovation. This new bulk handling feature is the perfect continuation of a number of game-changing technologies introduced to the market in order to optimise bulk handling. This includes Cycoptronic®, TeachIn, Pactronic® and of course also the LiSIM maritime crane simulators for professional crane operator training. In close proximity to its customers, Liebherr will continue to strongly invest in research and development in order to launch innovative features designed to increase safety and productivity while emissions are reduced at the same time.


Learning a language is a great way to communicate with people. A language can also open our eyes to other cultures and new horizons.
French is spoken by more than 220 million people on the five continents of the world. It is the language of culture, cookery, international relations and travel. The ability to speak and understand French can be an asset!
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English is the second most widely spoken language in the world, and the most commonly used among foreign language speakers. It is the 'lingua franca' of today's global world and is vital in such areas as technology, business and medicine. Enjoy tutorials with a native speaker.
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Is Resistance Futile? Picard Show Updates Have Some Fans Worried
On January 8, The Hollywood Reporter posted an article with new information from Alex Kurtzman about the upcoming series focusing on Jean-Luc Picard for CBS All Access.
In the article we learn that the series will focus on a "radically altered" Jean-Luc Picard dealing with the dissolution of the Romulan Empire following the destruction of the Romulan homeworld when a nearby star went supernova. The show's concept draws upon Picard's history with the Romulans in episodes of Star Trek: The Next Generation in which Picard in in conflict with the Romulan Empire as well as the "Unification" two-parter featuring Ambassador Spock wherein they attempt to unify Vulcan and Romulus in peace, as well as the film Star Trek: Nemesis wherein Picard deals with a Romulan ploy utilizing a clone of Picard. Alex Kurtzman told THR, "Picard's life was radically altered by the dissolution of the Romulan Empire." The series would explore the aftermath of the catastrophic event for the 2009 Star Trek film co-written by Alex Kurtzman and Roberto Orci.
Some fans have expressed concern with the idea that the destruction of the Romulan Homeworld would actually dissolve the entire Romulan Empire, since the Romulan Star Empire controlled vast tracts of space in the Alpha Quadrant. Other fans are equally unhappy with the idea of a "radically altered" Picard. Patrick Stewart has said, "He may not be the Jean-Luc that you recognize and know so well. It may be a very different individual; someone who has been changed by his experiences. Twenty years will have passed." While some fans just want and expect more of the Picard they know and love, others are worried that they will "Luke Skywalker" Jean-Luc Picard, referring to the recent depiction of the iconic Star Wars character which many fans felt was uncharacteristic and unrecognizable to the point that it ruined their appreciation for the story.
Alex Kurtzman told THR Patrick Stewart agreed to return only if he could defy what people are used to seeing with Trek, with Stewart saying "If we do this, I want it to be so different, I want it to be both what people remember but also not what they're expecting at all, otherwise why do it?" This further worries fans who were unhappy with the "defy expectation" approach Rian Johnson was said to have taken when writing and directing the recent Star Wars film The Last Jedi.
What are your thoughts? Are these concerns justified or an over-reaction? Are you fully on-board and excited for the Picard series, cautiously optimistic, or worried it will disappoint? Should characters be allowed to grow and evolve or should they remain the characters we know and expect?
Let us know what you think in the comments section below.
2 Comments to " Is Resistance Futile? Picard Show Updates Have Some Fans Worried "
Frank January 23, 2019 at 10:22 pm
Its wonderful that they are doing a Picard series. But don't change the character so much that you can't recognise them anymore. I want to know what happened to the federation after Voyager. Did we eventually come to terms with enemies like the Borg?
Name February 3, 2019 at 8:06 am
I am looking forward to seeing Next Gen, come back & I hope its with the same Story Lines as before, as this was one of the best we have seen & made you believe what you was watching.
Even though its 20 Years later I hope this will not change much, to what fans want & love.
Many times, Producers do not Listen to the Fans who made Star Trek, as it is & as all Fans knows Next Gen was the best, so as the old saying goes, why change what was good & what is the point if the viewing is lower due to the changes.
For me Picard can be an Admiral if not a Captain like a promotion to send Ships on mission's or visit other plants to get to join the Federation
Be nice to see a Star Trek Academy, training to see the Cadets train to become Officers, see them flying shuttle & Ships go on little missions etc.
To show us what is involved, to become a
Starfleet Officer, than just reading about it.
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No Orders to Close Poultry Shops
Broilers Equipment & innovation Government and regulatory Marketing poultry
19 September 2011, at 9:39am
KUWAIT - It is reported that there have been no official moves to shut live chicken shops, following some reports to that effect last week.
No advisory notice has been issued to the owners of live poultry outlets instructing them to shut down, according to staff at a number of these stores in Salmiya. Kuwait Times reports that although a number of Arabic language papers had reported the closure of some live poultry outlets in Kuwait as a "precautionary measure" to avert the possibility of any spread of the potentially deadly avian flu (bird flu) virus, workers at a number of these stores were adamant that they had received any such official notification.
The World Health Organization (WHO) recently issued an international alert on a possible new outbreak of the virus this winter, with the Public Authority for Agricultural Affairs and Fish Resources (PAAAFR) responding by asking the Kuwait Municipality to forcibly shut down all the country's live poultry sellers' outlets.
Instead, the PAAAFR has instructed that all such outlets should be replaced by properly regulated poultry breeding facilities with slaughterhouses on-site. Staff at local live poultry outlets insisted, however, that they have received no official notification of any closure orders.
"We haven't received any advisory from my employer or from the municipality to close down our shop," said one employee at a small live poultry outlet in Maidan Hawally.
There is no news of any bird flu in Kuwait, so why be scared?, asked Kuwait Times.
"I hope they won't do that [shut down the shop]," said the shop worker. He believed that poultry prices could be negatively affected by any bird flu scare. "If ever we were to be closed down, the price would probably be unstable again," he suggested.
Speaking on condition of anonymity, an official at the Ministry of Commerce and Industry (MCI), which supervises and regulates all commercial establishments, cast further doubt on the reports of upcoming closures, saying that no ban on live poultry outlets has yet been officially ordered and that the ministry has issued no instructions to do so.
Certainly, it appears that no such closures have yet been ordered or implemented. Although some members of the public have expressed concern at the news reports of a possible bird flu outbreak, other seem unworried.
One shopper at a local Cooperative Society store told Kuwait Times: "I don't think there's a reason to be scared. Besides, according to the reports, it could maybe spread in winter, so we still have time to prepare and check all the imported live and even frozen chickens."
- Go to our previous news item on this story by clicking here.


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Sonja Sohn, geboren als Sonja Williams (Newport News, Virginia, 1964) is een Amerikaanse actrice.

Carrière
Sohn speelde in 1998 naast acteur Saul Williams in de onafhankelijke film Slam en ze was bovendien een van de schrijvers van de film. De film won de hoofdprijs op het Sundance Film Festival. In 1999 speelde ze in Bringing Out the Dead van Martin Scorsese. In de periode van 2002 tot 2008 was ze te zien als Detective Kima Greggs in de HBO-serie The Wire, waarvoor ze in 2003 een Asian Excellence Award won. Vanaf 2011 speelt ze de rol van Detective Samantha Baker in Body of Proof.

Filmografie

|-

|- align=center
|2002-2008||align=left|The Wire||align=left|Detective Shakima 'Kima' Greggs|| 60 afl.
|- align=center
|2006-2007||align=left|Cold Case||align=left|Sarah || 5 afl.
|- align=center
|2008-2009||align=left|Brothers & Sisters||align=left|Trish Evans || 4 afl.
|- align=center
|2010||align=left|The Good Wife||align=left|Sonya Rucker || 1 afl.
|- align=center
|2011||align=left|Body of Proof||align=left|Samantha Baker ||
|-

|- align=center
|1998||align=left|Slam||align=left|Lauren Bell||
|- align=center
|1999||align=left|Bringing Out the Dead||align=left|Kanita ||
|- align=center
|2000||align=left|Shaft||align=left|Alice ||
|- align=center
|2001||align=left|Perfume||align=left|Dandy ||
|- align=center
|2002||align=left|G||align=left|Shelly ||
|- align=center
|2008||align=left|Step Up 2: The Streets||align=left|Sarah ||
|}

Externe link
Officiële website

Amerikaans acteur

redpajama_set_name: RedPajamaWikipedia


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Player Ratings: U.S. 1, Czech Republic 0
"Despite missing many of its veterans, the United States men's national team opened the cycle that will lead to the 2018 World Cup with a hard-fought exhibition win over the Czech Republic on Wednesday in Prague. The United States started strong, with a solid performance from its central midfield, composed of Alejandro Bedoya, Mix Diskerud and Joe Corona. It was through those three players that the Americans scored the game's only goal. Through it all, the team got outstanding goalkeeping from Brad Guzan and Nick Rimando, who are seeking to supplant Tim Howard during his hiatus from international play. Central defenders John Brooks, Michael Orozco and Tim Ream played well as well." NY Times
For U.S. youngsters, win vs. Czechs about ideology, not victory
"Future editions of U.S. Soccer's media guide will note Alejandro Bedoya scored the only goal in Wednesday's 1-0 win over the Czech Republic. Press reports will praise goalkeeper Nick Rimando for his stalwart second-half showing and box scores might indicate that Joe Gyau, Greg Garza and 18-year-old Emerson Hyndman made their international debuts. But that's all it is – trivia. The performances and moments that shaped Wednesday's friendly will have no bearing on U.S. coach Jurgen Klinsmann when he selects his team for the 2018 World Cup. And that's no slight against those men. Four years can be a soccer lifetime." SI
Leave a Comment »	| NY Times, USA	| Tagged: NY Times, USA	| Permalink
Five transfer window bargains
"It was another record-breaking transfer window in terms of money spent, but sometimes the most intelligent transfers cost extremely little and clubs that take a chance on overlooked players are frequently rewarded with fine performances. Here, then, are five of the bargains of this transfer window…" ESPN – Michael Cox
Leave a Comment »	| Football Manager, Germany, Manchester United, Michael Cox, Serie A	| Tagged: Football Manager, Germany, Manchester United, Michael Cox, Serie A	| Permalink
Tactical Analysis: Roma 2-0 Fiorentina | Giallorossi overcome Viola
"Roma 2-0 Fiorentina | A match that was about discipline and pressing culminated in the home side grapping their first 3 points of the Serie A 2014/15 season. With the result, Vincenzo Montella's record in the Olympico as a coach reads an uninspiring 8 matches, 0 wins, 2 draws and 6 losses." Outside of the Boot
Argentina takes World Cup final rematch with 4-2 win over Germany Print More
"Angel di Maria set up three goals and scored the fourth himself as Argentina trounced Germany 4-2 in their friendly game Wednesday to get a small measure of payback after losing to the host in the World Cup final. Argentina was up 4-0 after just 50 minutes to dampen the home side's World Cup title celebrations in its first game since winning the final 1-0 in extra time in Brazil in July. With Lionel Messi absent due to a right leg injury, Di Maria assumed the instigator's role, setting up Sergio Aguero in the 21st minute, Erik Lamela's outstanding volley in the 40th, and Federico Fernandez' headed goal two minutes after the interval." SI
Leave a Comment »	| Argentina, Germany	| Tagged: Argentina, Germany	| Permalink
Tactical Analysis: Tottenham Hotspur 0-3 Liverpool | Difference in pressing & runs from midfield
"Tottenham Hotspur 0-3 Liverpool | Two young managers, similar systems, exciting football, insistence on ground play, hard pressing, and quick pace. Both these sides and the men in charge had similarities, which even extended to their ambitions for the season. The game was meant to be close on paper, and turned out as planned for large parts of the opening 45, but the gulf in class showed as the game wore on with Liverpool emerging the better side." Outside of the Boot
Idiot Ruins Game? Brief Interviews With Not-So-Hideous Pitch Invaders
"When you see someone running on the field during a sporting event, you probably think, That will never be me. Announcers shake their heads so vigorously it produces an audible rustling of their collars. The word 'idiot' gets tossed around a lot — 'idiot on the field' is often the phrase of choice. In fact, the Great American Idiot, Homer Simpson, ran onto the field once: The headline read 'Idiot Ruins Game.' It seems like there have been a lot of these idiots recently. There was Jordan Dunn, the man who took the free kick in West Ham's opening match against Tottenham." Grantland (Video)
Julian Green is walking into a mismanaged disaster club at Hamburg
"Imagine if Chelsea, the team that ranks third in the all-time Premier League table, wasn't challenging for the title every year, but rather was fighting to avoid relegation. That'd be strange, right? Like watching a drunken executive wallow in the gutter. Chelsea isn't supposed to be down there. To continue this thought experiment, imagine Chelsea's answer, because it's a "big club" that aspires to more, and because it has some resources, was to bring back a former star–let's say Arjen Robben–to save the team. That'd be cool right? A returning hero riding into town to set things right again? This is basically the situation in the German Bundesliga, at Hamburger SV–the hero being Rafael van der Vaart, who returned to the club in 2012 but has been unable to affect much change." Fusion
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Gel-200 is a cross-linked hyaluronate single-injection device for treatment of osteoarthritis pain in the knee. This report summarizes new analyses of the safety of retreatment with Gel-200 from the 13-week, pivotal, multicenter, randomized controlled trial (RCT) followed by an open-label extension trial (OLE).
379 patients were enrolled in the RCT [Gel-200; phosphate-buffered saline (PBS)]. Safety of retreatment with Gel-200 was assessed by comparing adverse events (AEs) and device-related AEs reported through Week 4 following retreatment with Gel-200 to those reported in patients receiving their first injection in the OLE.
350 patients completed the initial RCT (231 Gel-200; 119 PBS); 258 patients enrolled in the OLE (162 Gel-200; 96 PBS). In total, 202 patients (125 Gel-200; 77 PBS) qualified for retreatment, while 56 (37 Gel-200; 19 PBS) did not. There were no significant demographic or disease characteristic differences between Gel-200 patients who were and were not retreated; those who were not eligible for retreatment experienced greater pain relief from Gel-200 in the RCT by all effectiveness endpoints (all p < 0.001), without differences in their safety profile. In the OLE, the safety of Gel-200, including percentages of patients who experienced any AEs (p = 0.547) and device-related AEs (p = 0.521), did not significantly differ between those receiving a second versus a first injection of Gel-200 following PBS in the RCT.
In the OLE, the safety of a second injection of Gel-200 was comparable to that of a first injection and effectiveness was similar, as previously reported.
Osteoarthritis (OA) is the most common inflammatory joint disorder in the world and one of the leading causes of disability . Intra-articular (IA) injection of hyaluronic acid (HA) which is a glycosaminoglycan chain that occurs naturally within the knee joint, or viscosupplementation, is a widely used treatment for relief of OA pain in the knee [2, 3]. In addition to the mechanical effect of HA lubricating the joint and protecting the cartilage from mechanical degradation, IA-HA treatment is believed to exert its therapeutic effect by providing chondroprotection and anti-inflammatory effect, stimulating endogenous proteoglycan and HA synthesis, limiting subchondral bone changes, and reducing the action of joint nociceptors [4, 5]. However, recent OA treatment guidelines by American Academy of Orthopaedic Surgeons (AAOS) and American College of Rheumatology (ACR) cast doubt on the utility of this therapy [6, 7]. This stands in contrast to the fact that many clinicians have found HA to be a valuable treatment option for those OA patients with cardiovascular, gastrointestinal, and metabolic comorbidities which render use of many systemic drugs unsuitable . Further analysis of clinical trial data should provide clinicians with more clarity on the utility of IA - HA over the discrepancy between guidelines and clinical practice.
Gel-200 (Gel-One®, Seikagaku Corporation, Tokyo, Japan) is a sterile, transparent, and viscoelastic hydrogel composed of a cross-linked hyaluronate, a derivative of a highly purified hyaluronate product. It was approved by the United States (US) Food and Drug Administration (FDA) in 2011 for the treatment of OA pain in the knee. The safety and effectiveness of a single Gel-200 injection was demonstrated in a 13-week pivotal multicenter randomized controlled trial (RCT) conducted in the US that recruited 379 OA patients. Analyses of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) visual analog scale (VAS) pain and physical function subscores, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT − OARSI) strict responders, and physician global assessments of disease activity in the initial RCT demonstrated statistically significant improvements in patients treated with a single injection of Gel-200 compared with a phosphate-buffered saline (PBS) control. At 13 weeks, 6.39 mm of treatment difference demonstrated a statistical significance in a 100-mm VAS WOMAC pain subscore (p = 0.037), and from 3 weeks through 13 weeks, 7.10 mm of treatment difference was shown (p = 0.005). Improvements in WOMAC pain subscore were evident as early as 3 weeks following injection with more than 40 % improvement from baseline and continued through 13 weeks. Adverse events (AEs) were not significantly different between the treatment groups, and no unanticipated treatment-related serious AEs were reported .
Patients who completed the 13-week RCT were eligible to enroll in the open-label extension (OLE). Patients were eligible for treatment with Gel-200 at any point while enrolled in the extension once they met the eligibility criteria. Retreatment with Gel-200 was shown to be safe for 13 weeks post retreatment by comparing AE data between treatment groups (retreatment with Gel-200 and initial treatment with Gel-200 following PBS), although the previous analysis did not provide in-depth examination of comparability between the two groups. In addition, a previously published analysis demonstrated that repeat treatment with Gel-200 for 13 weeks following retreatment relieved symptomatic OA as effectively as the initial injection with a favorable safety profile . For 13 weeks post retreatment, more than 30 mm improvement from baseline in WOMAC pain subscores persisted. The amount of pain relief provided by retreatment was greater than that reported over 13 weeks post initial treatment.
We report the results of additional analyses of the RCT and OLE data conducted to provide further evidence of the safety of a repeat injection of Gel-200.
Both the RCT, SI-6606/01, and the OLE, Gel/1132, were approved by a central institutional review board. The RCT was conducted from August 2006 to December 2007 (last patient visit) at 28 sites in the US, and the OLE was conducted from March 2007 to May 2008 (last patient visit) at 23 of those sites in accordance with good clinical practices. A signed consent form approved by the institutional review board was obtained for each patient. These trials were registered with ClinicalTrials.gov (identification numbers NTC 00449696 and NTC 00450112, respectively). Patients were eligible for enrolment in the 13 week RCT if they had pain >4 weeks, Kellgren-Lawrence grade 1–3 by X-ray, and WOMAC pain subscore ≥40 mm. Patients were instructed to use only those medications during the trial for OA they were receiving prior to enrolment, as well as not to use any medications for symptomatic pain relief within the 24 h prior to each evaluation visit. Patients were randomized to Gel-200 or PBS in 2:1 ratio and followed up to 13 weeks.
All patients who completed the 13-week RCT were eligible to enroll in OLE following an informed consent to the extension and retreatment study. Patients who enrolled in the extension study did not receive a Gel-200 injection unless and until their WOMAC pain score again met eligibility for entry into the RCT, ie, ≥40 mm on VAS in the treated and ≤20 mm in the contralateral knee, at any time after enrollment or at evaluations at 3, 6, 9, and 13 weeks in the extension phase. After meeting these criteria, patients received a single injection of Gel-200 (30 mg cross-linked hyaluronate in 3.0 mL) in the treated knee at Week 0 of the retreatment phase and returned for evaluations at Weeks 1, 3, 6, 9, and 13 following reinjection. Patients who did not meet the pain criteria through Week 13 of the OLE did not receive another injection. All patients remained blinded to the initial treatment received during the RCT. Patients were again instructed to use only allowed medications and not initiate use of any new analgesic or anti-inflammatory agents during the study, as well as to not use any medications for symptomatic pain relief within the 24 h prior to each evaluation visit.
The safety of retreatment with Gel-200 was assessed by comparing the rates of AEs and device-related AEs reported in the retreatment study through Week 4 in those patients receiving a second Gel-200 injection (Retreatment Group A) to the rates among patients receiving their first Gel-200 injection (ie, PBS patients from the RCT, PBS–Gel Group C).
To demonstrate the safety of retreatment with Gel-200, rates of AEs and device-related AEs up to 28 days after reinjection were compared between Retreatment Group A and PBS–Gel Group C using summary statistics and Fisher's exact tests.
To assess the suitability of Retreatment Group A for assessment of the safety of retreatment with Gel-200, demographics and baseline disease characteristics, rates of AEs, rates of device-related AEs, and primary and major secondary efficacy endpoints in the initial RCT were compared between Retreatment Group A and Nonretreatment Group B using descriptive and summary statistics, Fisher's exact tests, and t-tests, as appropriate.
Of the 350 patients who completed the pivotal RCT and were eligible to enroll in the OLE, 258 patients (74 %) enrolled; 92 patients (26 %) did not, including 69 who received Gel-200 (Fig. 2). Of patients enrolled in the OLE, 162 (63 %) were previously treated with Gel-200 in the initial treatment study, 125 patients (48 %) received a second injection of Gel-200 during the OLE (Retreatment Group A). Of 96 patients who received PBS in the RCT, 77 (80 %) received a Gel-200 injection in the OLE. A total of 37 patients who were treated with Gel-200 in the RCT and enrolled in the OLE did not qualify for retreatment and were combined with the 69 patients who received Gel-200 in the RCT but did not enroll in the OLE, for a total of 106 in Nontreatment Group B.
There were no significant demographic or baseline differences between Retreatment Group A and Nonretreatment Group B (Table 1). The mean age of patients was approximately 61 years, and approximately 59 % were female in both groups. The overall physical profile of patients in both groups was similar, including mean BMI of 28.4 kg/m2 and 28.3 kg/m2, respectively. The most common Kellgren-Lawrence score in both groups was 3, reported by 46.2 % of patients in Nonretreatment Group B and 58.4 % of patients in Retreatment Group A. The mean baseline of WOMAC pain subscores in the study knee were 68.1 and 69.0, respectively.
The percentages of patients who experienced AEs and device related AEs in the pivotal RCT were similar between Retreatment Group A and Nonretreatment Group B without statistically significant difference (Table 2). The most common AEs in both groups, reported by ≥5 % of patients, included joint swelling, joint effusion, arthralgia, and upper respiratory tract infection (URI). Rates were similar between the 2 groups for all of these AEs except for URIs, reported by 10.4 % in Retreatment Group A and 2.8 % in Nonretreatment Group B. Most common related AEs reported by ≥5 % of patients were joint swelling, joint effusion, and arthralgia. Rates of specific related AEs were also similar between the 2 treatment groups. Overall, the profile of the safety data collected in the RCT was similar between patients who did and did not receive retreatment with Gel-200 in the OLE.
For all assessments at all timepoints following initial treatment in the pivotal RCT (Weeks 3, 6, 9, and 13), there was a statistically significant difference between baseline and follow-up VAS WOMAC pain subscores within each group (all p <0.001). Mean scores and changes from baseline were also compared between the 2 groups. For all measures at all timepoints following treatment, mean scores and changes from baseline were significantly different between analysis groups (Weeks 3, 6, and 9 for the change from baseline in WOMAC stiffness subscores, p = 0.002; all others, p <0.001). At Week 13, the endpoint in the initial RCT, there were statistically significant differences (all p <0.001) between mean results in the 2 analysis groups for all WOMAC subscores, patient and physician global evaluation (Table 3). In all cases, mean changes from baseline were larger in Nonretreatment Group B compared with Retreatment Group A, indicating that patients experienced greater OA pain relief in Nonretreatment Group B.
The percentages of patients who experienced AEs and device-related AEs through 28 days following treatment in the OLE were similar in Retreatment Group A and PBS–Gel Group C (p = 0.547 and p = 0.521, respectively; Table 4). The most commonly reported AEs were in the musculoskeletal and connective tissue disorders system organ class, with the most common preferred terms, reported by ≥5 % of patients, being joint effusion, arthralgia, and joint swelling. Rates of specific device-related AEs were also similar between the 2 treatment groups. Overall, the safety profile following treatment with Gel-200 in the OLE was similar between patients receiving a second Gel-200 injection (retreatment) and those receiving an initial injection after receiving PBS in the pivotal RCT.
A recent meta-analysis of 29 studies of FDA-approved viscosupplements by Strand et al. demonstrated that these products are both safe and effective through 26 weeks in patients with symptomatic knee OA, which included the pivotal RCT of single injection Gel-200 that demonstrated its safety 13 weeks post injection . Consistent with the findings of this meta-analysis, a recent consensus statement issued by experts in Europe also confirmed the safety and effectiveness of viscosupplementation in clinical practice , in contrast to consensus statements in the US by AAOS and Osteoarthritis Research Society International (OARSI) [6, 13]. However, reports in the literature regarding the safety and effectiveness of viscosupplementation in patients with knee OA have been mixed. In a comprehensive meta-analysis of 89 trials that compared viscosupplementation with sham or a nonintervention control in adults with knee OA, Rutjes et al. reported that viscosupplementation was associated with a small, clinically irrelevant benefit and an increased risk of serious AEs and local AEs; however, the authors also noted that trial quality was generally low and safety data were often poorly reported . Another publication countered that viscosupplementation is safe [8, 15]. Thus, safety data continue to be analyzed for viscosupplementation products, and this issue has become more germane as safety of alternative treatments for knee OA is being debated .
Multiple single-injection viscosupplementation products are approved in the US for which the safety of a repeat injection has been examined [17–19]. For two of these products, follow-up occurred for at least 4 weeks after the reinjection, and 4 weeks of safety data were used as evidence for safety of a repeat injection. Thus, although a previously published analysis of the OLE study had demonstrated safety of a repeat injection of Gel-200 up to 13 weeks following retreatment , the current analysis examined safety data over 4 weeks following reinjection. The incidences of all AEs and device-related AEs were similar between patients receiving retreatment with Gel-200 and those receiving an initial injection. These results, consistent with the meta-analysis by Strand et al., indicate that retreatment with Gel-200 is generally safe and well tolerated . Additionally, when comparing reported AE rates of a repeat injection of Gel-200 over 13 weeks, AE rates at 4 weeks were much lower than those over 13 weeks . No acute AE that may raise a concern on safety of Gel-200 was identified.
The retreatment population rate in this study was lower than those reported in retreatment studies for similar products. Fewer patients who completed the pivotal Gel-200 RCT received retreatment in the Gel/1132 study. For example, in trials for approved viscosupplementation products Synvisc-One®, MONOVISC®, and EUFLEXXA®, reinjection rates of 63, 65, and 74 %, respectively, were reported, compared with a 53 % reinjection rate for Gel-200 in the OLE [17–19]. It was therefore important to determine that the Retreatment Group A was appropriate to include in this safety evaluation, representing the overall Gel-200 treatment population in the pivotal RCT. Overall, the patients retreated with Gel-200 in the OLE were similar to those who were not reinjected. There were no significant differences in demographics, baseline characteristics, or safety events reported in the pivotal RCT study for those who did and did not receive a second Gel-200 injection in the following OLE. These results show that the Retreatment Group A was an appropriate sample with which to examine the safety of retreatment with Gel-200. Moveover, patients who were not reinjected also did not appear to have any specific safety concerns about Gel-200 that would have precluded reinjection. Upper respiratory infections were reported by ≥5 % in patients with Gel-One in the 13-week RCT, also in patients receiving PBS, with a similar incidence (4.7 %). In both treatment groups, all cases were judged as not related to treatment by investigators. Nonretreatment patients also did not appear to have any concerns regarding effectiveness; patients in Nonretreatment Group B experienced greater OA pain relief following Gel-200 during the RCT than patients in Retreatment Group A. Additionally, those patients who did not consent to enter the OLE had better effectiveness results at Week 13 in the pivotal study. The high pain-relieving effect experienced by patients who received Gel-200 injection in Nonretreatment Group B may have contributed to their decision not to enter the retreatment study (data not shown), as it is plausible that for many of these patients, no retreatment was needed at the time that it was provided in the OLE study. Such potential evidence of long-lasting effectiveness of Gel-200 is consistent with the reporting of a recent network meta-analysis by Bannuru et al., which showed that HA injections were more effective in pain relief than other pharmacologic interventions once the effect of PBS injection serving as an active control was accounted for during the network meta-analysis [20, 21]. In the case of Gel-200, the potential evidence for long-lasting analgesic effect of Gel-200 in the RCT is corroborated by the finding from a previous animal study which showed that Gel-200 remained in the joint even 28 days after injection . There was no specific feature in patients who received the second Gel-200 injection. Patient demographic between patients who received the second Gel-200 injection and those who did not receive the second Gel-200 injection, were similar except for pain scores. However, these results also demonstrate internal consistency with previous findings from the same trial that those receiving an initial injection of Gel-200 had a longer time before meeting the threshold condition for retreatment eligibility than patients receiving PBS .
In conclusion, these additional analyses of retreatment from the OLE have confirmed the safety of Gel-200 following single and repeat injections in both pivotal and retreatment trials. Acute AEs were much lower and similar in incidence to non-acute AEs.
Moreover, pain scores before the retreatment indicated that non-retreated patients reported more improvement in pain than patients who ultimately received retreatment, suggesting that Gel-200 was sufficiently effective to obviate the need for retreatment in many patients in the RCT.
We wish to thank Theresa Scocca of Rho, Inc. for help with drafting the manuscript, Benjamin Vaughn of Rho, Inc. for help with the statistical analyses, and Becky Baggett of Rho, Inc. for administrative support.
The dataset supporting the conclusions of this article is stored in Seikagaku Corporation, Tokyo, Japan. Further inquiries on the data may be submitted to Junko Takamura (junko.takamura@seikagaku.co.jp).
VS provided clinical input for the analysis and interpretation of study results and conclusions as a medical expert and approved the final manuscript. SL and JT designed the statistical analysis plans, interpreted the data, and drafted, revised, and approved the final manuscript.
VS has served as a consultant to Seikagaku Corporation as well as Bioventus, Carbylan, Eupraxia, Flexion, Iroko, and Sanofi. SL and JT are employees of Seikagaku Corporation and are listed as inventors of a hyaluronate product.
Both RCT and OLE studies were approved by the eMedicus institutional review board in US. Informed consent was received from all study participants.
American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee evidence-based guideline 2nd edition. 2013. http://www.aaos.org/research/guidelines/TreatmentofOsteoarthritisoftheKneeGuideline.pdf. Accessed 22 September 2015.
Prescribing Information for Synvisc-One™ http://www.accessdata.fda.gov/cdrh_docs/pdf/p940015s012b.pdf.
Prescribing Information for MONOVISC™ http://www.accessdata.fda.gov/cdrh_docs/pdf9/P090031b.pdf.
Prescribing Information for EUFLEXXA® http://www.accessdata.fda.gov/cdrh_docs/pdf/P010029S008b.pdf.


In late August, my mother unexpectedly lost her brother, my Uncle Steve. It turns out, he had been battling stomach cancer for the past year, but the family was unaware. He passed away very suddenly, and my mom didn't get a chance to even say goodbye before he was gone. It was a very shocking experience.
I spent some time over the next week thinking about my Uncle Steve, and the light he brought to the world and those around him. That's the way I wanted to remember him; full of joy. It then occurred to me that art would actually be a fantastic way to keep Uncle Steve's memory alive, and I knew just the way to do it.
My Uncle Steve was among the most loyal University of Alabama fans in the country. He lived and breathed that football team, and could tell you anything and everything about the players and the coaches. It was his passion. Nothing brought Steve more joy than game days, and the thrill of victory when Alabama won was always the icing on the cake.
I did some searching online for a great photo of Bryant Stadium, where the University of Alabama plays at home games. I found a terrific shot with a creative commons license that I could use, and then I headed over to Gallery Direct to turn a photo into a beautiful piece of art.
The original photo size was not the standard requested size for Gallery Direct, but they have incredible customer service, and worked with me to make the piece work in a setting. This is something I absolutely love about this store: if you have a question or problem, just email or call them and they will work with you to resolve it. They want to make sure that you get exactly the type of custom framed art that you want, whether it be using a print they have in stock, or a photograph of your own.
I decided to put the photo in an aluminum floated frame option, and I really love the result. It's sleek and modern, but also timeless. It also really lets the excitement of the image shine through as the star.
When I look at this picture, it's impossible for me to not think of my Uncle Steve. It's also impossible for me not to smile. This proudly hangs in my parents' home as a reminder of Steve and of the happiness that football brought to him. I can't think of a better way to remember him than on game day, and this piece of framed art helps my family to remember him exactly that way, every day.Your turn: Do you have any creative ways that you remember loved ones who are no longer with you? Have you ever thought of using art as a way to keep memories alive?
Disclosure: I serve as a blog ambassador for Gallery Direct. Product samples are provided as part of the program. All thoughts and opinions expressed here are strictly my own.
Thats too bad about your Uncle, its hard losing family. Pretty cool about being a die hard Alabama fan, Im that way with the PBR (professional bull riding.) My hsband had a son from a previous relationship, and the girl was a real pyscho, we tried so hard to get hom from her. Everybody always believed her, she had muncheusen, so no bruises, hes ok, is what they thought. When we first were together, I worked at the mall and a lady was there doing an art show, I had her draw a picture of his son. This was in 2002 I had him drawn, in 2007 she killed that little guy. She is in prison now, and my husband had that drawing tattoed on his arm.


text:
Women's college basketball: Baylor loses big lead, star player, still finds way to down Notre Dame, win national championship
Doug Feinberg | The Associated Press
Baylor players celebrate after defeating Notre Dame for the women's Division I national championship Sunday in Tampa, Fla. Baylor won 82-81.
TAMPA, Fla. — Baylor lost a star player, then the rest of its 17-point lead. But the Lady Bears, led by the ever-poised Chloe Jackson, kept their composure.
Jackson drove for a tiebreaking layup with 3.9 seconds left, and that put the game into the hands of another tournament hero.
Notre Dame's Arike Ogunbowale missed the first of two free throws with 1.9 seconds remaining, and Baylor held on for an 82-81 victory Sunday in the NCAA women's basketball championship game.
"They just kept doing what we've been taught to do, and that's guard people," Baylor coach Kim Mulkey said. "We just beat the defending national champions. That team is so good, so talented. You're going to see those guys play at the next level. Wow."
Baylor was able to pull off the win without star forward Lauren Cox, who injured her knee in a frightening scene late in the third quarter. The Irish were able to rally from a 14-point deficit in the third quarter to tie it at 78 in the fourth. Jackson then scored a jumper from the foul line, and Jessica Shepard countered with two free throws to tie it, setting up the exciting finish.
"We had to do it for L.C.," said Jackson, who was named the Final Four's Most Outstanding Player. "She got us here. We had to finish the job for her."
The Lady Bears (37-1) won their first championship in seven years. Mulkey and Baylor have won titles in 2005, 2012 and 2019. The 2012 championship game also pitted the Lady Bears against Muffet McGraw's Irish in the last meeting of two female coaches for the title.
The Lady Bears were primed to run away with the game as Notre Dame struggled to score. But the Irish have a knack for big comebacks, doing it against UConn in this year's semifinal and against Mississippi State in last season's title game, when they rallied from 15 down in the third quarter.
Ogunbowale was instrumental in all those victories, forever becoming a part of the Final Four during last year's title run. She made a shot with one second remaining to beat UConn in the semifinals, then hit a tiebreaking 3-pointer with one-tenth of a second left to top the Bulldogs in the title game.
Ogunbowale led the charge again Sunday, scoring 17 of her 31 points in the second half. That included a buzzer-beating 3 at the end of the third quarter, sparking an 11-0 Notre Dame run.
"It just wasn't meant to be. It's going to be a hard pill to swallow," Ogunbowale said. "But things happen. I had a fun, great career here at Notre Dame."
It helped the Irish that the Lady Bears had to play the last 11 minutes without Cox. She got tangled up with Kalani Brown on the defensive end and went down clutching her left knee with about a minute to go in the third quarter. The 6-foot-4 junior was crying in agony before they took her off the court in a wheelchair. Her mom was tearing up in the stands, and her dad had his hands over his face.
"I'm emotional for a lot of reasons, but mostly for Lauren Cox, and I'm so happy," Mulkey said. "These are tears of joy, but they're also tears of thinking about injuries.
"The worst part of the game was Lauren Cox," she added. "We had control of that game from the start to the time she went off the floor. We had to regroup. For us to win was a miracle in itself when you lose a player of that caliber."
Cox came back to the bench in the fourth quarter on crutches, with a big brace on her left knee. She was the first one to hold the trophy after the game.
"I'm one of the leaders on the team, so just to have my voice there (on the bench) and tell them I'm still OK, they told me they were going to do this for me," Cox said.
Mulkey was able to celebrate her third title with her family close by. Daughter Makenzie is on the coaching staff, and infant grandson Kannon Reid was sitting in the front row behind the bench. As the final second ticked off, she hugged her daughter and the rest of the staff at midcourt.
Baylor 82, Notre Dame 81
NOTRE DAME (35-4): Shepard 4-10 3-5 11, Turner 4-11 4-4 12, Mabrey 7-15 3-3 21, Ogunbowale 11-27 6-8 31, Young 1-8 2-2 4, Vaughn 1-1 0-0 2, Prohaska 0-0 0-0 0. Totals 28-72 18-22 81.
BAYLOR (37-1): Cox 3-6 2-2 8, Brown 10-16 0-5 20, Jackson 13-25 0-0 26, Landrum 3-12 0-0 8, Richards 3-5 0-0 6, Smith 7-9 0-0 14, Ursin 0-0 0-0 0. Totals 39-73 2-7 82.
Notre Dame 14 17 24 26 — 81
Baylor 25 18 23 16 — 82
3-Point Goals—Notre Dame 7-13 (Mabrey 4-8, Ogunbowale 3-5), Baylor 2-7 (Landrum 2-7). Assists—Notre Dame 18 (Young 6), Baylor 21 (Landrum 6). Fouled Out—Baylor Smith. Rebounds—Notre Dame 43 (Turner 12), Baylor 38 (Brown 13). Total Fouls—Notre Dame 13, Baylor 20. A—20,127.
Related Topics: college basketball, women's college basketball, Baylor University, University of Notre Dame, NCAA Women's basketball tournament


text:
El Cantó d'Eiriçon és un cantó francès del departament de l'Alier, situat al districte de Montluçon. Té 17 municipis i el cap és Eiriçon.

Municipis
 Auda
 Bijanuelha
 Lo Breton
 Cosne-d'Allier
 Estivareilles
 Givarlais
 Eiriçon
 Louroux-Bourbonnais
 Louroux-Hodement
 Maillet
 Nassigny
 Reugny
 Saint-Caprais
 Sauvagny
 Tortezais
 Vallon-en-Sully
 Venas

Història

Demografia

Eiricon


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text:
UK watchdog launches inquiry into teacher who admitted molesting boys
The UK teachers' watchdog has launched an investigation into alleged misconduct by an American teacher who the Guardian revealed was hired by two British schools despite previously admitting molesting boys.
Stephen Jackson was fired in late September by Tendring Technology College when Essex police alerted senior staff to concerns about him. The 72-year-old was recruited to teach English to 11- to 14-year-old boys despite facing multiple child abuse allegations in the US. He also taught at Haberdashers' Aske's Knights Academy in Bromley from 2009 to 2011.
The investigation by the National College of Teaching and Leadership was launched shortly after Jackson left the country in October. He has previously admitted to police in Santa Cruz, California, that he was attracted to 14- to 16-year-old boys, that he touched a boy's penis on a camping trip, molested a pupil aged 15 or 16, and slept in the same bed as one of his students. US investigators also received evidence suggesting he may have sexually assaulted his four-year-old adopted son.
Jackson, who was also known as Myers, was dismissed after teaching for just 13 days at Tendring college when police raised child protection concerns.
Giles Watling, the school's local MP, said the case appeared "shocking", and demanded answers on why he was not identified earlier. "I want to ascertain how the system can be improved to ensure it never happens again," he said.
Tendring College said it did not tell parents about Jackson because it had no child protection issues with him while he was there, but insisted it had acted swiftly.
Jackson was recruited by an employment agency, Red, which said it carried out checks with the FBI and Colorado Bureau of Investigations but nothing showed up. Despite police investigations, Jackson has never been charged or convicted. Knights Academy said "all the legally required checks were carried out".
Read the full article UK watchdog launches inquiry into teacher who admitted molesting boys
Please tell us your thoughts in comments or via Twitter ~ Tamsin
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Tickets to 2017 ARIA Awards with Apple Music have sold out.
With only 5 more sleeps until the 2017 ARIA Awards with Apple Music, we are thrilled to announce that tickets to the awards have officially SOLD OUT, but fans can view all the action on the ARIA Red Carpet presented by Swarovski from 2.00pm AEDT live on Twitter.
Today sees the final announcement of the Australian and International stars who will be presenting on the night at The Star Event Centre, Sydney which you can watch exclusively on the Nine Network on Tuesday 28th November, from 7:30pm AEDT.
With a final round of presenters announced today, the assembly of artists and entertainers now also include one of Australia's most successful rock band INXS, beloved Australian Comedian and Pitch Perfect 3 star Rebel Wilson along with her co-stars Brittany Snow, Anna Camp and new addition Australian Actress Ruby Rose will be in attendance to present 'Best International Act'. The presenters will also include ARIA Award winning Songwriter Josh Pyke, seven-time consecutive ARIA nominee Jessica Mauboy, Melbourne MC and Australian hip-hop artist Seth Sentry, four time ARIA recipient Katie Noonan, Australian sweetheart and personality Sophie Monk, UK's double platinum artist and global phenomenon Harry Styles, NZ's Pop sensation LORDE and and Creative Director and DJ for Apple Music's global radio station Beats 1, Zane Lowe.
They will join radio presenters, the dynamic duo Ben and Liam from triple j's Breakfast, Triple M presenter Jane Gazzo, Smallzy from NOVA's 'Smallzy's Surgery' and Ash London from Hit Network's 'Ash London Live'. Ash will also be a host of the Swarovski Red Carpet joining the crown prince of comedy Joel Creasey and Aussie model, actress, singer and social influencer Alli Simpson. This line-up adds to the previously announced presenters Flume, Jimmy Barnes, Julia Michaels, Mick Fleetwood and Vance Joy, promising a star-studded show.
ARIA are also announcing Virgin Australia as the official airline partner as well as the ARIA Emerging Artist Scholarship presented by Virgin Australia, which will be revealed at this year's ARIA Masterclass, with the lucky winner announced in January 2018. The Scholarship is an amazing opportunity for a lucky musician, and will be judged by a panel of ARIA representatives and Virgin Australia.
The 2017 ARIA Awards with Apple Music have an exciting, diverse and eclectic final line-up featuring 'Apple Music Album Of The Year' nominees Gang Of Youths, Paul Kelly and A.B. Original, 'Best Female Artist' nominee Jessica Mauboy, 'Best Male Artist' nominee Dan Sultan, 'Breakthrough Artist' nominee Amy Shark and 'Apple Music Song Of The Year' nominees Peking Duk and Pnau. Also announced today are performances from 'Best Pop Release' nominee Vera Blue and 'Apple Music Song Of The Year' nominee Guy Sebastian. Fans will also be treated to a very special 'Hall Of Fame' performance by Daryl Braithwaite.
Tickets to the 2017 ARIA Awards with Apple Music have SOLD OUT, but fans can view all the action on the ARIA Red Carpet presented by Swarovski from 2.00pm. Tune in to the 2017 ARIA Awards with Apple Music from 7.30pm exclusively on the Nine Network on Tuesday, November 28.


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Pregnant and In School?
Whether you're in high school or college, being in school is a transformative time in a person's life. It's understandable for an unplanned pregnancy to come as a shock. In fact, it can bring out all sorts of questions regarding the future, including how you could potentially care for a child, and what this pregnancy would mean for your education and future plans. If you're unexpectedly pregnant and in school, the New Direction Women's Center team can help guide you through the process so you can make a healthy, informed decision.
As a student, you might be wondering:
Will I be able to finish school?
What does this mean for college and/or getting a job?
How will my parents and friends react?
How will I tell my boyfriend/partner?
These are just some of the questions you are likely to ask yourself, but it's important to remember that no matter what you're thinking, you are not alone. Whatever way you're leaning, and whatever you ultimately choose, New Direction Women's Center is here to provide help and support. If you think you may be pregnant, please schedule an appointment with us today.
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text:
Q: Why pygame screen won´t refresh until I move the window arround? I´m a newbie on pygame, and i have this code for trying to do kind of a startscreen for a football game, this start screen has a static background image that is"img_start_screen" and the logo of the game that I want it to have a little animation that stops when it reaches the certain point on the screen, that logo is the variable "logo"
import pygame,sys
from pygame.locals import *
pygame.init()
screen=pygame.display.set_mode((1280,720))
pygame.display.set_caption("CEFoot 3.0")
FPS=60
fpsClock=pygame.time.Clock()
img_start_screen=pygame.image.load("start_screen.gif")
logo=pygame.image.load("logo8bit.png")
logox=390
logoy=0
direction="down"
while True:
    window.blit(img_start_screen,(0,0))
    if direction == "down":
        logoy+=5
        if logoy==300:
            direction="center"
    if direction == "center":
        pass

    screen.blit(logo,(logox,logoy))

    for event in pygame.event.get():
        if event.type==QUIT:
            pygame.quit()
            sys.exit()
    pygame.display.update
    fpsClock.tick(FPS)

The problem is that when I run the code it starts as a black screen and not until I move the window "out" of the Windows screen it refreshes, the images aren´t the problem as I ran the code without them and it showed the same black screen. I´m beginning to think that it isn´t code problem but compability as I´m running Python 3.2 and Pygame 1.9(I think) the last version that is really old , all this on Windows 10, so this might be the problem.Thanks in advance.

A: As you know pygame.display.update is a function
as seen if you print it:
>>> print pygame.display.update
<built-in function update>

so when you call pygame.display.update without parenthesis () you are merely stating a reference to a function. Whereas if you use parenthesis you call the function:
>>> print pygame.display.update()
None

this calls the function and returns None

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This page documents the current workflow used to draft, edit and send out issues of the Debian Project News.
Please note, that the following states only the ideal workflow. Because of some constraints of the editors or due to expected events (e.g. when one ftp-master ask the issue to be delayed for a couple of hours, so the mail he is about to send out can be mentioned in the issue) the following timeline might be stretched.
After every release svn.alioth.debian.org/svn/publicity/dpn/en/current is moved to the proper location (e.g. 2010/01). Then a new current folder is created and the index.wml-template is copied in there, to start with an empty and fresh news. During that time the "Status"-Field in the header is set to "open-to-edit".
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We are available by email or phone 24 hours a day, 7 days a week. Please contact us or stop in for more information or to enroll in our classes. We are open from 9 AM-5 PM Monday-Friday. Call us at 508-846-2387 for more information or to enroll in classes TODAY!


assassins creed network is not displaying accurate info! it says Borgia tower completion 0 when i have completed 3 as well as courtesan hired 1 when i hired 2 and 3 mercenaries when i never did. as well as some other false info like i never fixed any shops etc. any help as to how to fix this?


High crime rate, low sense of security.
The December National Survey on Urban Public Security reveals that more than 90% of the adult population in eight cities feel unsafe where they live.
Topping the list compiled by the national statistics institute, Inegi, was the border city of Reynosa, Tamaulipas, torn by violence generated by warring drug gangs. There, 96% of inhabitants older than 18 feel unsafe.
Next up was Chilpancingo, Guerrero, with 93.8%, followed by 93.4% in the cities of Puebla, Coatzacoalcos, Veracruz, and Ecatepec, México state.
Not far behind were Villahermosa, Tabasco, with a rate of 92.3%; Tlalnepantla, México state, with 90.4%; and Fresnillo, Zacatecas, where 90.1% of its adult population live in fear.
Some of the cities further down on the list were notable for the change since December 2017. In Piedras Negras, Coahuila, the rate was 61.9% but that's up more than 20 points in one year.
Others were Guanajuato where the rate rose over 19 points to 79.6%; Guadalajara, where it increased more than 15 points and reached 86.8%; and Monterrey, Nuevo León, where the number of people who felt unsafe increased by more than 13 points over the previous year, reaching 84.4%.
Nationally, 73.7% indicated they felt unsafe.
Broken down by gender, 78% of women reported feeling unsafe. Among men the figure was 68.6%.
The national survey also found that over one-third of Mexican households have been victims of theft or extortion.
As for the future, there are great expectations.
While only 17% thought things would get better at the end of 2017, the number soared to 41.4% at the end of 2018, the highest rate ever recorded and one that probably stems from the public's high hopes for President López Obrador.
At the bottom end of the insecurity spectrum lay the city of San Pedro Garza García, Nuevo León, with 23.1%, the lowest rate in the country.
It was followed by Mérida, Yucatán, at 28.8%; Saltillo, Coahuila, at 30.5%; Puerto Vallarta, 38.7%; Durango, 39.5%; and Los Cabos, 42.3%.


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Nicole Loeffler-Gladstone
Nov. 28, 2014 07:00AM EST
"happyokay" Was More Than Okay—It Was Awesome
Dance is best seen live. Whether it's in an intimate black box or on a huge proscenium, you can't go wrong. But there's something extra-special about seeing a performance in a space you wouldn't normally associate with dance. It's what makes site-specific work or dance made for the camera so cool. Sometimes, though, you don't know what you're in for, and well, who doesn't love an awesome surprise?
(A still shot of Megan LeCrone in happyokay by Last Hour, directed by Elena Parasco)
A couple weekends ago, I went, on a whim, to see a performance event called "happyokay," held at Livestream Public—a repurposed warehouse in Brooklyn. The place is known for film showings, art happenings and literary discussions—not so much for presenting dance—so I wasn't really sure what to expect. And when I walked in, I wasn't getting many clues: Three projection screens hung from the ceiling and audience members were invited to stand around a panel of marley flooring.
(Megan LeCrone and Harrison Ball in a still from happyokay)
It turned out that the show was an epic collaboration between video collective Last Hour, an Amsterdam-based artists collective called House of Makers and...members of New York City Ballet! That's right guys, I was practically face-to-face with dancers Harrison Ball, Joseph Gordon and Megan LeCrone. Sure, I've seen them perform onstage at Lincoln Center's David H. Koch Theater, but it was really special to see their artistry and musculature so up-close and personal. Just goes to show that sometimes, you gotta take a leap into the unknown when you're going to see dance. You never know what surprises await.
(Still from happyokay)
Wish you could have been there? Luckily for you, the event was filmed so you can watch the whole thing here!


What to do with the children this summer? Candy Craze, the premium candy bar, creamery and party supply store, responded in innovative style Saturday last at its Gourmet Milkshake workshop — the first in a series of kids' workshops taking place at the Upper Manor Park location.
The enthusiastically received workshop saw children creating one-of-a-kind milkshakes from the store's wide selection of candy. On hand was the helpful Candy Craze Vibes team who ensured that the young gourmands in attendance had a truly individualised experience. They certainly did with faces lighting up in glee as they tried their hands at making candy kebabs, added frosting and selected ice-cream. At the end of the workshop each child received a Candy Craze goodie bag.
The fun continues this Saturday, July 28, when the sweets emporium will host a candy sushi workshop, beginning at 1:00 pm.


This course is a comprehensive overview and discussion of the evaluation; management; and medical, surgical, and radiation treatments of the pituitary tumor. The conference will comprise lectures, case-based talks, and Q&A panel sessions.
The pituitary gland plays an enormously important role in human development, the maintenance of various essential physiologic functions, and aging and senescence. Hence, the health of the pituitary gland is critical at all stages of human life. For this reason, there are a variety of pituitary disorders that can have profound impact on multiple organ systens at different ages. General practitioners and even specialists in endocrinology may not be fully aware of the widespread impact of the pituitary gland in health and disease; the function of this course is to educate and inform a general medical audience on pituitary disease.
For more information visit their website or contact Tatiana Soto at [email protected] or 212-746-0403.


Find out why the South African Journal of Business Management transitioned to an open access this year, after having being a toll access journal since 1979. Dr Lara Skelly, Research Manager at the University of Stellenbosch Business School, which is the owner of the journal will give some tips to authors on what to expect when publishing in an open access journal.
Find out the key milestones for the African Journal of Primary Health Care & Family Medicine, the issues to be addressed and its new goals from its Editor-in-Chief, Prof. Bob Mash, in this 11-minute podcast interview.
The South African Journal of Childhood Education (SAJCE) editorial team invites research that highlights student teachers' pre-service education in schools. Submissions deadline: 30 August 2018.
In 2019, the African Journal of Laboratory Medicine (AJLM), ajlmonline.org will publish a special issue devoted to The Future of Diagnostics.
AOSIS is proud to announce that the Jàmbá: Journal of Disaster Risk Studies is now included in PubMed Central® (PMC).


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Your consolation link list
November 2, 2010 By Stephen Smith
Apologies to everyone for the light posting – over the next few weeks I may be a bit busy with job and internship applications (any suggestions for work or job offers would be very much appreciated!), but hopefully I'll still be able to put up a few posts a week. But for now, all you get is this mammoth link dump:
1. Vancouver's laneway housing program (which we discussed earlier) has been off to a brisk start, and though planners are looking to liberalize sewer rules, they're also considering only allowing one-story houses as-of-right, and limiting the amount of new laneway houses per block.
2. Former Market Urbanism contributer Sandy Ikeda writes about the urban origins of liberty at the Freeman.
3. The Dukakis Center has released a report suggesting that the gentrification caused by new light rail lines might cause driving to increase, defeating the purpose of TOD. Megan McArdle has also been discussing gentrification. Hopefully I'll write something about this and gentrification more generally soon, but I wanted to post this in case I don't get around to it. Any thoughts from the commenters on why this is and how it can be avoided?
4. North Korea "declare[s] war" on its version of the jitney, the "servi-cha."
5. LA is the only big city in America whose fire department mandates that all skyscrapers have flat roofs so as to allow helicopters to land, but this may be changing (Curbed, parts 1 and 2).
6. Disabled riders file a class-action lawsuit against NYC's MTA "for not spending a federally mandated 20% of [subway] station rehabilitation budgets on improvements like elevators and ramps." The ADA's impact on mass transit and urbanism is something that I'd eventually like to discuss more in depth, but I haven't seen much research or even many anecdotes about it – perhaps our commenters have some insight?
7. Delhi is getting 345 km of new BRT lanes, although they seem to be coming at the expense of private buses, which were taken out of service as a test during the Commonwealth Games in a move that will now become permanent. The most common complaint appears to be safety, and though the private Blueline buses are going to be replaced in the short-run by private contracted service, it looks like the city is seeking to socialize mass transit in the long-run. This seems to echo the pattern seen in many developing countries of municipalizing transit service, with examples both recent (Santiago, Chile, now and then) and from America's own past. Some dense Asian cities bucked the trend, but they seem to be the exception rather than the rule. Mass transit, perhaps more than any other industry, has escaped the recent global trend towards privatization.
8. Developers working on a large new affordable housing development in Brooklyn claim that it wouldn't have been possible if it weren't for a "mayoral override of the parking requirement," which allowed them to not build a single parking space. I'm happy that they were granted the exemption, but I wonder how many smaller or less politically-connected developers are oversupplying parking or deciding to not build at all because of the requirements.
Might a "Don't steal from highways to fund mass transit" sign be in our future?
9. Sam Staley suggests that the Tea Party movement might get involved in local land use decisions. But given their wishy-washy libertarianism and overwhelming suburban/rural orientation, I doubt they'd break out of the standard pro-car NIMBY mold and advocate for a true market in land use and transportation.
10. "Development specialists" have convinced Cambodia to privatize its interurban passenger and freight rail service, though land title issues for settlements that have sprung near tracks may pose difficulties.
11. New York City passes a pedicab regulation bill, which Meredith Sladek criticizes for giving local community boards the power to restrict pedicabs from operating in their neighborhoods, as well as for its outright ban on motors (which have at most half the power of a lawnmower) to assist the cyclist.
Filed Under: Uncategorized Tagged With: conservatism, disability, gentrification, Los Angeles, North Korea, nyc, parking, pedicabs, portland, Randal O'Toole, Southeast Asia, transit-oriented development, Vancouver
About Stephen Smith
I graduated Spring 2010 from Georgetown undergrad, with an entirely unrelated and highly regrettable major that might have made a little more sense if I actually wanted to become an international trade lawyer, but which alas seems good for little else.
I still do most of the tweeting for Market Urbanism
Stephen had previously written on urbanism at Forbes.com. Articles Profile; Reason Magazine, and Next City
it looks like the city is seeking to socialize mass transit in the long-run. This seems to echo the pattern seen in many developing countries of municipalizing transit service
This is a bad trend. Mexico hasn't gone very far down this road yet, but the municipal services are always lethargic. Wait times are long, trips can take hours, and coaches are uncomfortable. Private service zips along with one tram always waiting behind the one that just passed.
Of course, BRT, underground rail, light rail, and the like require central management. That is unfortunate for rpaid transit because quality, competent, and honest public management is rare in Latin America (though not as rare as it seems in the USA).
Stephen Smith says
If by "central management" you mean government management, I don't think this is necessarily the case – there are private mass transit companies in Japan and Hong Kong, and obviously private ownership was widespread during the period of major expansion around the turn of the last century. However, I will grant you that allowing new private mass transit would require a certain amount of vision and good governance that Mexico doesn't seem to possess. Perhaps when the US stops forcing Mexico to fight its drug war, though, things will change…although I fear that won't be for quite a while.
Jeff Jacobberger says
The Dukakis Center's report compares 1990 and 2000 census data for areas near transit stations opened during the 1990s. However, about 1/3 of the stations studied opened in 1995 or later (a couple opened in late 1999), which suggests that most of the demographic changes at those stations have nothing to with the TOD. The study looked at the Castro Valley BART station, which happens to be located in the middle of a freeway, with an entrance surrounded by a fairly large parking lot. A look at GoogleEarth suggests that, even 10 years later, there is almost no development near the station that could remotely be considered transit-oriented and it is a bleak pedestrian environment. Moreover, the Castro Valley is very close to the San Mateo Bridge and 880 Freeway, which provide access to what was, during the 1990s, the booming high-tech Silicon Valley, which has very poor transit service. Any change in commute mode seems likely to be explained by a change in commute patterns that is wholly independent of and outweighed the presence of a new BART station. I wonder how many other stations studied are mid-freeway, suburban locations where land uses had not yet had time to adjust to the new transit station.


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Home / Non-Fiction / History
The World Refugees Made: Decolonization and the Foundation of Postwar Italy
The World Refugees Made: Decolonization and the Foundation of Postwar Italy quantity
SKU: 9781501747588 Category: History Tags: Pamela Ballinger, refugees
In The World Refugees Made, Pamela Ballinger explores Italy's remaking in light of the loss of a wide range of territorial possessions–colonies, protectorates, and provinces–in Africa and the Balkans, the repatriation of Italian nationals from those territories, and the integration of these national refugees into a country devastated by war and overwhelmed by foreign displaced persons from Eastern Europe. Post-World War II Italy served as an important laboratory, in which categories differentiating foreign refugees (who had crossed national boundaries) from national refugees (those who presumably did not) were debated, refined, and consolidated. Such distinctions resonated far beyond that particular historical moment, informing legal frameworks that remain in place today. Offering an alternative genealogy of the postwar international refugee regime, Ballinger focuses on the consequences of one of its key omissions: the ineligibility from international refugee status of those migrants who became classified as national refugees.
The presence of displaced persons also posed the complex question of who belonged, culturally and legally, in an Italy that was territorially and politically reconfigured by decolonization. The process of demarcating types of refugees thus represented a critical moment for Italy, one that endorsed an ethnic conception of identity that citizenship laws made explicit. Such an understanding of identity remains salient, as Italians still invoke language and race as bases of belonging in the face of mass immigration and ongoing refugee emergencies. Ballinger's analysis of the postwar international refugee regime and Italian decolonization illuminates the study of human rights history, humanitarianism, postwar reconstruction, fascism and its aftermaths, and modern Italian history.
–Atina Grossmann, Cooper Union, author of Jews, Germans and Allies
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Casey & the Flying Fortress
Caesar: A Life in Western Culture
Gladiators: Deadly Arena Sports of Ancient Rome
Reconstructing The Renaissance
Hannibal's Niece
Rome's Greatest Defeat: Massacre in the Teutoburg Forest
The Confessions of Young Nero
John F. Kennedy In New England


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Trump's Likely Pick to Empower Women Is Mad That Disney Movies Don't Feature Enough Strong Male Leads
You read that right.
Penny Nance with Concerned Women for America speaks during a meeting held by Budget Director Mick Mulvaney in the Eisenhower Executive Office Building on the White House complex on May 25, 2017. Andrew Harnik/AP
It's hard to imagine a more ironic choice for America's next ambassador-at-large for women's issues.
The position is tasked with overseeing State Department programs to end gender-based violence and empower women and girls around the world. So, naturally, President Donald Trump is reportedly considering Penny Young Nance, a far-right Christian activist who opposed reauthorization of the Violence Against Women Act; recently cheered on an attempt to block a pregnant teen immigrant from an abortion; and has called on Hollywood to write more scripts featuring strong male leads.
Nance is the CEO and president of Concerned Women for America. The group's agenda, according to its website, includes "protecting and supporting the Biblical design of marriage," "protecting the sanctity of human life," "ending sexual exploitation by fighting all forms of pornography, obscenity, prostitution, and sex trafficking," and "defending religious liberty."
Speaking on Fox & Friends, Nance put it this way: "We're the women's group who love men."
At the CWA, Nance has called to defund Planned Parenthood and promoted the false idea that abortion is linked with breast cancer. Her organization argued that transgender kids shouldn't have the right to use school bathrooms matching their gender identity, and it opposed a federal bill that would ban workplace discrimination on the basis of sexual orientation or gender identity.
Nance has even taken aim at the Disney mega-hit Frozen, which featured two strong female princesses. Nance went on television to criticize the film's portrayal of men. "Hollywood in general has often sent the message that men are superfluous, that they're stupid, that they're in the way," she said on Fox & Friends.
Congressional aides told Politico last week that the Trump administration was considering Nance for the envoy position, but it's not clear whether she would be able to get confirmed. Democrats are expected to push hard against the appointment and she recently criticized Republican Sens. Bob Corker and Jeff Flake for their decisions to retire from Congress—both senators sit on the Foreign Relations Committee, which approves or rejects ambassador nominees.
When Flake, a vocal Trump critic, announced his retirement by saying "there may not be a place for a Republican like me in the current Republican climate," Nance tweeted that he "sounded like a middle school girl."
Republicans have only a narrow majority on the Foreign Relations Committee, so if either Corker or Flake joins Democrats in opposing Nance, her bid for the job will fail.
Appeals Court Paves the Way for Migrant Teen to Get an Abortion
Hannah Levintova
Trump Nominee Cited Dred Scott Slavery Decision as Sound Precedent
P.R. Lockhart


The Thung Yai Naresuan (East) Wildlife sanctuary (TYNE) is clarified as the Tiger Conservation Landscape of Global Priority and also a stronghold for other endangered and threaten species. Although, UNESCO designated this area, the cores of the Western Forest Complex (WEFCOM), as a Natural World Heritage Site in 1991, this wildlife has been threatened by habitat alteration, prey depletion, and direct killing. Yet, the information on impact of human activities and wildlife status that is needed to guild forest authorities to develop conservation strategies remains challenging. The goal of this dissertation was to increase understanding of tiger, other main predators, prey status, and also impact of human activities in the sanctuary. In the TYNE, the globally endangered species were observed including Asiatic Elephant (Elephas maximus), Tiger (Panthera tigris), Malayan Tapir (Tapirus indicus), Dhole (Cuon alpines), and Malayan Pangolin (Manis javanica). Spatially explicit capture-recapture approach estimated tiger density at 1.4-1.6 tigers/100 km2 and leopard density at 0.7-0.8 leopards/100 km2, which indicates that there might be 27±10 tigers (95% CL range from 11-46) and around 12±4 leopards (95% CL range from 8-19) roaming in the area around 1,596 km2 in TYNE. The large predators like tigers, leopards, and dholes co-occurred in the area with the combination of both spatial and temporal partitioning due to differences in predator and prey activity and low overlap in space use correlated to their prey preferences. Prey availability, human settlement areas, and human disturbance activities are the key limiting factors for their distribution and space-use. The habitat use of tiger and leopard demonstrated that the population distribution was limited in the central to the eastern part of the TYNE, while the local people occupied the west with high disturbance activities. The activities by local people in TYNE were varied and the impacts of the disturbance were complex. Slash and burn, livestock, tree cutting, and poaching appeared to be the major influence wildlife abundance and habitat around the settlement areas. The results of this study stress the need for the further conservation and management to maintain wildlife distribution and populations in the future. Better scientific understanding of wildlife biology, ecology, and social sciences would help to deal with the conservation and management issues facing the local communities and natural resources in Thung Yai Naresuan (East) Wildlife Sanctuary.
Vinitpornsawan, Supagit, "Population and Spatial Ecology of Tigers and Leopards Relative to Prey Availability and Human Activity in Thung Yai Naresuan (East) Wildlife Sanctuary, Thailand" (2013). Doctoral Dissertations 1896 - February 2014. 533.


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Book a guided raft trip and brave Flora Rapids or Sullivan Hole. Shop 'til you drop at the Spokane Valley Mall. Explore trails in the Dishman Hill Natural Area. When you're done, enjoy the sunset with a glass of wine at Arbor Crest Winery's magnificent Cliff House. Spokane Valley is the perfect place to begin your adventure.


CBD oil lotion is also quite popular since there are dual purposes at play. They'll smooth out and even soften the skin of the applied area. Of course, they also allow highly specific use of CBD. It's not uncommon for people to become very adamant that CBD oil Skin Care in West Orange become a regular part of their lives after trying it for the first time. The FDA isn't keen on any particular health claims being made of course, but it's hard to deny the satisfaction rate of those that have been using CBD topicals thus far.
THC is quite well known, having been included in the conversation about marijuana for quite some time now. CBD has become more prominent as of late thanks to plenty of research and trials however. It has been shown to help prevent pain, anxiety, and even nausea. It also happens to be legal when extracted from industrial hemp. There is still much work to be done towards achieving widespread understanding and use of topical products such as CBD Skin Care in West Orange , but it's clear that we're many steps closer than ever before.


text:
Çanakkale Province
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Çanakkale Province (Turkish: Çanakkale ili) is a province of Turkey, located in the northwestern part of the country. It takes its name from the city of Çanakkale.
Çanakkale ili
Province of Turkey
Location of Çanakkale Province in Turkey
Coordinates: 40°02′27″N 26°33′37″E / 40.04083°N 26.56028°E / 40.04083; 26.56028Coordinates: 40°02′27″N 26°33′37″E / 40.04083°N 26.56028°E / 40.04083; 26.56028
West Marmara
• Electoral district
9,737 km2 (3,759 sq mi)
Like Istanbul, Çanakkale province has a European (Thrace) and an Asian (Anatolia) part. The European part is formed by the Gallipoli (Gelibolu) peninsula, while the Asian part is largely coterminous with the historic region of Troad in Anatolia. They are separated by the Dardanelles strait, connecting the Sea of Marmara and the Aegean Sea.
The archaeological site of Troy is found in Çanakkale province.
Short historyEdit
In the early Turkish Republic, the Çanakkale Province came into existence with the abolition of the Ottoman-era sanjaks of Biga and Gelibolu. According to a population census in 1927, Çanakkale had 8,500 inhabitants, except its neighbouring villages. It is recorded that Çanakkale, which was also called as "Hellespontos" and "Dardanelles" in ancient times, has accommodated to many civilizations for about 3,000 years. Even the Archaic Troy (Troia) city, where was governed by Lydians and destroyed by the devastating earthquake in 2500 BC, has ruins in today. In 336 BC, Persian Empire which became the crucial power in Anatolia and was conducted by Alexander the Great that aimed to extend ancient Greece all over the world, was defeated. Also with the ruin of the Anatolian beylik of Karesi, most of the territory of Canakkale was conquered in the Ottoman era, with the assistance of the castles in remuneration for helping to Byzantine Empire, locating Gelibolu. Afterwards, the Canakkale strait was given to the Ottoman Empire.
AgricultureEdit
The province of Çanakkale is a notable region for viticulture and winemaking in Turkey. The region between Saros Gulf and Gelibolu on the Gallipoli peninsula is cultivated with vineyards.[2] Wine producer "Suvla" is located in Suvla.[3]
Çanakkale province is divided into 12 districts (capital district in bold):
Ayvacık
Bayramiç
Biga
Çan
Eceabat
Gelibolu
Lapseki
Çanakkale Trojan Horse
A ferry going from the town of Çanakkale to Gallipoli peninsula
A view of Çanakkale from the Dardanelles
Historical clock tower in Çanakkale town center
List of populated places in Çanakkale Province
^ "Population of provinces by years - 2000-2018". Turkish Statistical Institute. Retrieved 9 March 2019.
^ Akyol, Cahit (2005-06-04). "İşte Türkiye'nin şaraplık üzüm haritası". Hürriyet (in Turkish). Retrieved 2015-07-28.
^ "Çanakkale'den Yepyeni Bir Şarap Markası: 'Suvla'" (in Turkish). Çanakkale'nin Rehberi. Retrieved 2015-07-28.
Wikimedia Commons has media related to Çanakkale Province.
‹See Tfd›(in Turkish) Çanakkale governor's official website
‹See Tfd›(in Turkish) Çanakkale Belediyesi
‹See Tfd›(in Turkish) Çanakkale
‹See Tfd›(in English) Çanakkale weather forecast information
‹See Tfd›(in English) Pictures of the capital of the province and its sights
Retrieved from "https://en.wikipedia.org/w/index.php?title=Çanakkale_Province&oldid=898241495"