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GHB in Biological Specimens: Which Cut-off Levels Should be Taken into Consideration in Forensic Toxicological Investigation?
Author(s): Francesco Paolo Busardo, Chrystalla Kyriakou	Department of Anatomical, Histological, Medico-legal and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336 (00185) Rome, Italy., Italy
Journal Name: Recent Patents on Biotechnology
DOI : 10.2174/1872208309666150504143155
Gamma-hydroxybutyrate (GHB) is a central nervous system depressant endogenously produced and also employed as a recreational drug of abuse since the 90s, attracting notable attention particularly in those cases of drug facilitated sexual assault (DFSA). The implication of GHB among DFSA cases generates numerous concerns, making the interpretation of the toxicological findings often significantly difficult. In this review the Authors have explored GHB behaviour in ante-mortem and post-mortem specimens, taking into consideration its endogenous production, the post mortem interval, the time between sampling and analysis, the storage conditions (temperature and presence/absence of preservatives) and the usefulness of alternative matrices such as hair, bile and vitreous humour. Moreover, the cut-off values currently recommended in forensic toxicology in order to discriminate between endogenous and exogenous levels have been examined.
Keywords: Gamma-hydroxybutyric acid (GHB), cut-off values, endogenous and post-mortem behaviour, post-mortem interval (PMI), storage conditions.
Recent Patents on Biotechnology
Title:GHB in Biological Specimens: Which Cut-off Levels Should be Taken into Consideration in Forensic Toxicological Investigation?
Author(s):Francesco Paolo Busardo and Chrystalla Kyriakou
Affiliation:Department of Anatomical, Histological, Medico-legal and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336 (00185) Rome, Italy.
Keywords:Gamma-hydroxybutyric acid (GHB), cut-off values, endogenous and post-mortem behaviour, post-mortem interval (PMI), storage conditions.
Abstract:Gamma-hydroxybutyrate (GHB) is a central nervous system depressant endogenously produced and also employed as a recreational drug of abuse since the 90s, attracting notable attention particularly in those cases of drug facilitated sexual assault (DFSA). The implication of GHB among DFSA cases generates numerous concerns, making the interpretation of the toxicological findings often significantly difficult. In this review the Authors have explored GHB behaviour in ante-mortem and post-mortem specimens, taking into consideration its endogenous production, the post mortem interval, the time between sampling and analysis, the storage conditions (temperature and presence/absence of preservatives) and the usefulness of alternative matrices such as hair, bile and vitreous humour. Moreover, the cut-off values currently recommended in forensic toxicology in order to discriminate between endogenous and exogenous levels have been examined.
Francesco Paolo Busardo and Chrystalla Kyriakou, "GHB in Biological Specimens: Which Cut-off Levels Should be Taken into Consideration in Forensic Toxicological Investigation?", Recent Patents on Biotechnology (2014) 8: 206. https://doi.org/10.2174/1872208309666150504143155
https://doi.org/10.2174/1872208309666150504143155 Print ISSN
Published on: 05 June, 2015
DOI: 10.2174/1872208309666150504143155
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Small, but well-formed. The new home deposit scheme will help, and it's unlikely to push up prices
by Rachel Ong Viforj, The Conversation
It won't help enough, but it will get some people their keys. Credit: Shutterstock
The new First Home Loan Deposit Scheme announced the Coalition, and instantly backed by Labor, is likely to be popular among those on the cusp of buying their first home.
It'll be open to singles earning up to A$125,000 and couples earning up to A$200,000 who have saved at least 5% of the value of the home. The government-owned National Housing Finance and Investment Corporation will partner with private lenders to put up as much as another 15% of the value of the home to take the deposit to 20%.
However, the scheme is capped at 10,000 home buyers per year, roughly one tenth of the number of Australians who bought first homes in 2018.
It'll help them—the latest survey shows that more than half of first homebuyers needed financial assistance outside of their own savings to get their deposit. The benefits of home ownership have been widely documented. But will it do enough?
Source of deposits
An often-expressed concern is that such a scheme will bid up house prices. However, it is means-tested, making it much less vunerable to this criticism than the non-means-tested First Home Owners' Grant.
And is also capped at 10,000 loans per year, giving it little scope to price pressure.
Authors' own calculations from ABS Survey of Income and Housing 2013-14
However, it may not be means-tested enough.
Consider the population subgroup that broadly comprises aspiring homebuyers who qualify for the scheme: renters aged 25-34 years who meet the scheme's income criteria and whose financial wealth is between 5% and 20% of the lowest-priced quarter of houses for sale in the borad area in which they live.
In the most-recent 2015 ABS Survey of Income and Housing there were 127,000 such potential eligible first home buyers, more than 12 times the 10,000 cap.
The cap is a practical necessity of course, needed to limit impacts on prices and prevent a cost blowout. But the weakness of the scheme is that the cap will be filled on a "first come, first serve" basis, without distinguishing between those who actually need help and those who are likely to meet the deposit requirement anyway.
The graph shows that some 40% of potential first home buyers have managed to save a deposit amounting to not much more than 5% of the home value. Only 7% have a 20% deposit or something near it.
Deposit saved by renters aged 25-34 who meet the scheme's eligibility criteria, per cent of lower quartile property prices in area of residence, 2015-16. Authors' own calculations from the ABS Survey of Income and Housing 2015-16
Potential users of the scheme, by amount of deposit saved
The Coalition (or Labor) could get more bang for its buck within the cap by targeting those in greater need of assistance; for example by prioritising those who cannot access the so-called Bank of Mum and Dad. Not everyone has access to wealthy parents.
The Great Australian Dream of owning a home has been fading fast, and not just for young people. Naturally, the scheme's details of the scheme require scrutiny. But overall, it provides a welcome acknowledgement (by both major parties) that the affordability crisis facing young people has not waned despite recent house price declines.
The scheme will restore the opportunity – at least to some – to accumulate wealth in property and enjoy the security and other benefits that home ownership brings.
But seriously addressing housing affordability will ultimately require a bigger intervention.
Shared home ownership helps people with disability, researchers find
Provided by The Conversation
Citation: Small, but well-formed. The new home deposit scheme will help, and it's unlikely to push up prices (2019, May 15) retrieved 15 July 2019 from https://phys.org/news/2019-05-small-well-formed-home-deposit-scheme.html
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You are here: Home > Latest news > Current Article
SLO restaurateur rides a wave of business, tourism growth
By Elijah Brumback / Friday, March 27th, 2015 / Comments Off on SLO restaurateur rides a wave of business, tourism growth
The city is building an impressive lineup of new restaurants, which are filling up vacant real estate.
The Rooster Creek Tavern in Arroyo Grande. The restaurant's owner, Bill Hales, is bringing the eatery's concept to San Luis Obispo. (Courtesy photos)
After partnering to open more than a dozen concepts, San Luis Obispo native Bill Hales has learned a thing or two about the restaurant business.
Hales and a revolving cast of business partners are eating up opportunities to fatten up their portfolio of locations while the market continues to expand.
His most recent endeavor is similar to Rooster Creek Tavern, an establishment he co-owns in Arroyo Grande. The new unit is slated for the revamped University Square shopping center in San Luis Obispo.
Hales is working with developer Nick Tompkins on the development at the long-vacant building that housed Bank of America on Foothill Boulevard.
The concept is described as a wine-centric, family-friendly restaurant that also appeals to young professionals. The 5,000-square-foot location will feature a patio, brick pizza oven, full bar and will have the flexibility to handle large events.
The not-yet-named casual dining concept has an up-market design and will have food, beer and wine offerings in line with Rooster Creek.
Hales is also considering another restaurant for a site on Tank Farm Road and Broad Street near the new Mindbody headquarters. He didn't give further details on the project as it's early in the development process.
"That project is still just dirt," he said. "We've got plenty on our plate this year, so we're not really worried about pushing that one forward too quickly."
For the University Square project, the space is expected to be ready by late April or in early May. Once it's done, Hales said he'd like to shoot for an August opening, but September or October is more realistic.
"There are always delays," he said. "We've done enough of these to know that we need to be conservative with our expectations."
Hales got his start in the bar and restaurant industry 20 years ago mopping floors. Since then his holdings have expanded to include stakes in a dozen restaurants, with 14 total by the end of 2016. He's also getting ready to open Mason Bar, a small gastropub that will serve farm-to-table dishes alongside a bevy of craft beer on Branch Street in Arroyo Grande.
Arroyo Grande's Rooster Creek Tavern.
Bruce Baltin, vice president of CBRE's hospitality research firm PKF Consulting USA, said the influx of new restaurants shouldn't come as a surprise since the region has been successful in gathering significant tourism traffic from promotional efforts.
"The area is undergoing a period of upgrading," he said. "Hotels and motels are upgrading to meet the demands of a greater quantity and quality of guests and that's being reflected in the restaurant scene. Efforts to market the area have really been taking hold and that's helped push the local businesses forward."
An example of that momentum is the expansion of barbecue joint Rib Line to the Villages at Broad Street. The company, featured on Travel Channel show "Man v. Food," will be taking its popular tri-tip, ribs and chicken to the 2240 Emily St. location. It will be the company's second restaurant in SLO and third overall; its other location is in Grover Beach. According to those familiar with the project, the new location will feature an open kitchen design, seating for more than 80 and a 10-person bar.
SLO Brewing Co. is also planning to open a larger brewing facility near the airport at 855 Aero Vista Lane. The development includes roughly 19,000 square feet of commercial space. The Business Times previously reported that the popular Ventura-based seafood joint Spencer Mackenzie's also launched a new location on Higuera Street.
The space between fast-casual and fine dining has experienced the most activity, said Lee Johnson, the city of San Luis Obispo's economic development manager. In the city's financial statements for the fourth quarter of 2014, tax revenue from dining establishments shot up more than 10 percent over last year, he said.
The city is building an impressive lineup of new restaurants, many of which are filling up the remaining available spaces. There are a few developments coming online in the long term that will bring some new commercial space, but there could be an upcoming lull in the action, Johnson said.
Two 5,000-square-foot commercial buildings are proposed for a site at Santa Rosa and Monterey streets, and The Junction, a proposed 69-unit apartment complex, includes 3,000 square feet of commercial space — but those projects will take time.
"The big thing is that this kind of activity is important to keeping the quality of life aspect of the city up, where people have options and can get different styles of cuisine at different price points," Johnson said.
With Cal Poly strengthening its reputation as a research university, a growing student population and the county's wine industry in full flight, there have been more visitors from the Los Angeles and San Francisco area, and that's given Hales and his partners more room to experiment with bringing new dining concepts to SLO County.
Hales also co-owns the Shell Beach Brewhouse, Mother's Tavern, Creeky Tiki, Frog and Peach Pub, The Library Lounge, Bull's Tavern, McCarthy's Irish Pub, Wine Shed and two eateries in Mississippi.
Based on the "booming success" at the Shell Beach brew pub, Hales and his partners are looking at Nipomo and Pismo for future concepts, he said.
"For us it's been a place we've always had an interest in and it's where I'm from," Hales said of the area's growing dining scene. "The area isn't really a secret anymore, which is pretty amazing because it used to just be the vacuous hole where you'd stop to get gas on your way up north."
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Лейбористська партія Сент-Люсії — соціал-демократична партія в Сент-Люсії.
На 2022 рік партія обіймає 13 з 17 місць у  та 6 з 11 місць у .

Історія
Партія була створена в 1950 за підтримки Кооперативного союзу робітників Сент-Люсії
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На перших виборах, проведених в  році, партія, очолювана , здобула п'ять із восьми місць у Палаті зборів.
Вона зберегла всі п'ять місць на виборах  року і збільшила свою більшість до семи із восьми місць в  році та дев'яти із десяти місць у  році.

В  році партія вперше програла вибори: , що відкололася від Лейбористської партії, об'єднавшись з Народною прогресивною партією, здобула шість із десяти місць, а Лейбористська партія зберегла лише два. На виборах  року партія здобула ще одне місце, а  року збільшила своє представництво до семи місць, хоча ОРП залишилася при владі, оскільки загальна кількість місць зросла до 17 місць.

Лейбористська партія повернулася до влади після перемоги на виборах  року на чолі з , якого протягом терміну змінив на посаді прем'єр-міністра , а його замінив .
Вибори 1979 стали першими виборами, проведеними після здобуття незалежності від Сполученого Королівства, проголошеної 22 лютого 1979 року.

Партія програла ОРП вибори  року, зайнявши тільки два місця, крім того, одне місця здобула Прогресивна лейбористська партія, що відкололася.
Вона залишалася в опозиції після двох виборів у квітні , збільшивши свою присутність до 8 місць на обох виборах, а також у  р. (6/17).

Очолювана колишнім міністром кабінету міністрів  партія виграла вибори  року, здобувши 16 із 17 місць.
Вона залишилася при владі і після виборів  року . (14/17).

На виборах  року вона програла ОРП, яка за рік до цього відкликала  з посади лідера
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Кенні Ентоні залишався лідером партії протягом часу її перебування у лояльній опозиції.
Лейбористська партія виграла вибори в  році, здобувши 11 з 17 місць і перемігши лідера ОРП , який в 2007 році змінив Джона Комптона на посаді прем'єр-міністра після його смерті.

Лейбористська партія програла вибори ОРП в 2016 році з 11 місцями проти 6, Кенні Ентоні пішов з посади лідера партії.
18 червня 2016 року як лідер партії був затверджений колишній заступник прем'єр-міністра Філіп П'єр.
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Прем'єр-міністри від партії

Примітки

Політика Сент-Люсії

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Be proud of the time and dedication it took to become a PADI Dive Master. Wearing this handsome Dive Master will catch people's eyes. You never know, you might start a conversation with a future dive body or, that special someone you've had an eye on at the office also makes a great gift for that diving significant other or your diving friend.


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BREAKING: CIW to join Abby Wambach, Glennon Doyle on national Together Live Tour!
This morning, the CIW announced a major partnership with U.S. Women's soccer superstar Abby Wambach and New York Times bestselling author Glennon Doyle: CIW's Lupe Gonzalo will be joining Glennon, Abby, and a dozen other powerful women leaders – including Olympic Medalists, authors, actors, and activists – for eight stops in major U.S. cities on the second annual Together Live Tour!
The tour will feature "badass earth-shakers, hilarious heroines, and authentic storytellers" in order to inspire and energize audiences around the country to find purpose and effectuate change. Representing the CIW's own badass Women's Group, Lupe will bring the incredible story of the Fair Food Movement – in which consumers around the country joined together with farmworkers to transform the agricultural industry – to tens of thousands of new allies nationwide and invite them to join the Wendy's Boycott.
On tour with Abby and Glennon, Lupe will launch the Fair Food Sisters campaign, a brand-new community initiative for women's rights advocates around the Fair Food network to stand together and take action to eliminate the abuses that plague farmworker women outside the Fair Food Program.
Head over to the CIW's website to read more, and find out if Together Live is visiting your city!
ANNOUNCING: Farmworker women launch "Harvest without Violence" campaign in the Wendy's Boycott!
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America spends more on health care than any other country. According to the Centers for Medicare and Medicaid Services, the nation spent $3.3 trillion — or $10,348 per citizen — in 2016. Of course, one would assume these expenditures would make us one of the healthiest countries on the planet, but when it comes to our average life expectancy, that's not the case.
In fact, according to three new reports published by the Centers for Disease Control and Prevention, the average life expectancy declined… for the second time in three years. But that isn't the most disturbing part. According to the report, the reason for the decline was the rapidly increasing rates of death from suicide and drug overdoses.
"Life expectancy gives us a snapshot of the nation's overall health and these sobering statistics are a wakeup call that we are losing too many Americans, too early and too often, to conditions that are preventable," Redfield said in a statement.
More than 70,000 people died of drug overdoses last year, according to the CDC — a 10 percent increase from 2016 — and suicide remained the 10th-leading cause of death, though suicide rates were significantly higher in 2017 compared with 1999 (particularly among males).
The good news is the CDC stated they remain "committed to putting science into action to protect U.S. health" and reverse these trends. However, as Redfield noted, the government-funded organization can not fix these issues alone. "We must all work together to reverse this trend and help ensure that all Americans live longer and healthier lives," Redfield said.
And Redfield's right. We can reduce overdoses and suicides by learning about them. By talking about them. And by having tough and uncomfortable conversations with our friends, our family, our children and our peers.
If you or someone you know is having suicidal thoughts, please call the National Suicide Prevention Lifeline at 1-800-273-8255, visit SuicidePreventionLifeline.org or text "START" to 741-741 to immediately speak to a trained counselor at Crisis Text Line. And if you or someone you know is struggling with alcoholism, substance abuse and/or mental health issues, please contact SAMHSA's national helpline at 1-800-662-4357.


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Research & Trends The rise of the innovation oriented city
Your current selection: Germany
Move into your first workplace, find a new one with room to grow, or develop a complete location strategy.
Breathe life into old space, or create something brand new to help your people thrive.
Implement tools, processes, and strategies that improve the value and performance of your real estate.
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The rise of the innovation oriented city
A number of the world's most dynamic cities are implementing ambitious urban development projects to be cutting-edge and driven by innovation.
Bigger is no longer better when it comes to our cities: They need something more than raw growth to give them the edge and drive them forward.
That something is known as innovation and it's increasingly becoming a core part of our successful modern cities. It's also affecting how they develop. Real estate no longer just accommodates innovation – but can actively foster and encourage it.
A number of the world's most dynamic cities are implementing ambitious urban development projects to bolster their positions as cutting-edge 'tech hubs' – cities which have the ecosystems, environments and appeal needed to thrive in the modern world.
This commitment to innovation is driving their momentum, says Jeremy Kelly, Director, Global Research at JLL. "City momentum is built on the foundations of a strong and innovative economy, as technology transforms the world around us and becomes embedded in everything we do," he says. "As such, tech hubs, from global super cities – like London and Tokyo – to smaller, specialized centres – like Austin and Auckland, are well positioned for the future."
The emergence of 'Innovation Districts'
Innovation is increasingly shifting away from out-of-town science parks and back into city centers. More and more young, tech-savvy workers and start-ups are being drawn to mixed-use, well-connected, and highly liveable neighbourhoods where the proximity of housing/residential areas, businesses and institutions can foster a community built of innovation, collaboration and communication. It's happening in cities across the world from London's Tech City around Shoreditch to Boston's Kendall Square and San Francisco's SOMA neighbourhood.
These districts are often centred on anchor institutions, which tend to be universities or research centres. New York and London – two of the world's super cities – are explicitly creating spaces within which businesses and universities can come together and work towards the successful commercialisation of academic research.
Kelly says: "Both cities are already magnets for talent, home to several world-class universities and are global commercial centres but, in the face of increasing competition from more specialized smaller cities, must work hard to maintain their innovation credentials."
New York is developing a new graduate campus on Roosevelt Island (Cornell NYC Tech), which has received huge support from the city and will have a first-of-its-kind in-house patent officer. In London, the regeneration of White City will include a research quarter centred on the new Imperial West campus, while the new UCL East campus will bring academic research strengths and an innovation centre to a redeveloped Stratford, which already includes the 'Here East' tech centre. These developments are set to harness the diverse strengths of each city.
'New World Cities' are transforming
The development of new 'innovation districts' can be seen in numerous cities, beyond just global super cities. Auckland's Wynyard Quarter, for example is a waterfront mixed-use development that includes a dedicated 'Innovation Quarter' centred on the GridAKL incubator, and is part of the city's explicit aim to become a leading innovation hub in Asia-Pacific.
Meanwhile, Boston has rechristened the city's Seaport District as an 'innovation district', drawing on the city's exceptional higher education institutions, including Harvard and MIT. The area is home to District Hall, the U.S.'s first public innovation center, and the MassChallenge accelerator and is currently experiencing a raft of new development. Elsewhere in the U.S., Seattle's South Lake Union has undergone huge transformation into a life sciences hub, led by the relocation of Amazon's corporate campus in the neighbourhood (having moved from suburban Redmond), while San Francisco's Mission Bay is undergoing a similar revitalization.
Meanwhile in Dublin, the Docklands area has attracted the likes of Google and Amazon and now further development is on the way with the designation of the North Lotts and Grand Canal Dock area as a 'strategic development zone' (SDZ). Each of these cities is building on its strengths, its liveability factors and its higher education credentials to specialize in technology – despite their relatively small size.
Yet this shift toward innovation is not strictly an established city phenomenon. The best performing emerging cities which include the likes of Bangalore, Shenzhen and Hyderabad can be considered among their countries' leading tech hubs. Nairobi is starting to establish itself as Africa's tech hub – 'Silicon Savannah'. As part of an ambitious plan for 2030, the city is planning Konza Techno City, a purpose-built, tech-focused 'city' 64km south of Nairobi.
"Each of these cities has gained impressive momentum thanks to their focus on innovation," says Kelly. "The demand for space from tech companies is driving both rental increases and new construction, strong higher education provision is forming the basis for long-term success, and this overall attractiveness is drawing both investment and wider interest from a global audience."
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Eliot Lewis is a singer songwriter and multi-instrumentalist as well as being a key member of the the Daryl Hall & John Oates band. Eliot is also one of the original featured musicians on MTV's "Live From Daryl's House." His contributions stand out on some of the best moments from the show including performances with Billy Gibbons (ZZ Top), Joe Walsh, Todd Rundgren,Train, Grace Potter, Ben Folds, Booker T, Jewel, Rob Thomas, Keb Mo, Jason Mraz, Darius Rucker, Gavin DeGraw and many, many others. Earlier in his career Eliot spent several years as a key member of the The Average White Band. Eliot toured, wrote and also produced several songs for the Scottish soul band.
Having mastered four instruments over the course of his career; guitar, keyboard, bass and drums, Eliot Lewis blazed his own trail as a solo artist sharing his distinctive brand of rock & soul through solo releases and hundreds of solo tour dates all over the world. Eliot's songs come from the inside out. "I think the main inspiration for any of my records is to convey these little slices of life, most of my songs are written about my own experiences and situations".
Along with recording a select set of episodes for "Live From Daryl's House," Eliot is currently working on his next album slated for release the first half of 2019, along with a tour. "An Evening with Multi Instrumentalist Eliot Lewis" consists of very unique performances where he plays all instruments on stage!


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Sacrifice of the Mass
Death penalty: Pope Francis hasn't changed the teaching; he just 'developed doctrine'
Carl Jacobs
One of the more curious aspects of Roman Catholic apologetics is its inability to answer certain specific questions to which it should have ready answers: 1. What is the content of Sacred Tradition? This seems kind of important since Sacred…
Muslims flock to Mass to show solidarity and compassion
Praying before a blasphemous icon of another Jesus, standing in the shadow of a sacrificial cross which they deny, beneath the dome of a cathedral church steeped in idolatry,…
Fireman Sam slips on the Qur'an, and all Sharia breaks loose
Firstly, it wasn't Fireman Sam who apparently slipped on a page of the Qur'an; it was Elvis. But the headline 'Elvis slips on the Qur'an' would probably cause problems…
Is the Pope Anglican?
The American Spectator isn't at all happy with the "liberal" Pope Francis and his "caricaturing of conservatives". That's Roman Catholic traditionalists, as opposed to the GOP-type conservative. "Under the…
Fr Raniero Cantalamessa – Preacher to the Papal Household – to speak at Synod Eucharist
As the Queen and Supreme Governor of the Church of England inaugurates the tenth General Synod on 24th November, it has been announced that the ceremony will be preceded…
Horrible Histories meets Monty Python – the reinterment of King Richard III
According to Leicester Cathedral, the cost of designing a space to accommodate the tomb of King Richard III has been £1.54million. The cost of the reinterment events, interpretation and…


Mr Zardari already enjoys the status of co-chairman of PPP.
The decision was taken at a meeting of the CEC presided over by PPP Chairman Bilawal Bhutto Zardari at the Naudero House.
Briefing newsmen after the meeting, PPP General Secretary Raja Pervaiz Ashraf and Qamar Zaman Kaira said the decision was unanimous.
They said the matter was not on the agenda, but the proposal came in from provincial presidents of the party. It was welcomed and unanimously adopted.
The CEC meeting was exclusively held to pay tribute to Benazir Bhutto.
The meeting paid tribute to the leadership of Makhdoom Amin Fahim, who was the PPPP president, and said he remained committed to the party till his last breath. The meeting observed one-minute silence for the departed soul.
They said the CEC discussed the Rangers powers issue and it was decided that no-one should be "hurt". It observed that the tense situation would weaken the provinces.
The PPP leaders said the prime minister himself had said that the Sindh chief minister would be the captain of the operation and the province had been assured that it would be taken into confidence.
They expressed the hope that during his coming visit to Karachi on Dec 28 the prime minister would revive the reconciliation policy agreed upon by him and Benazir Bhutto under the Charter of Democracy.
Answering a question, Raja Ashraf stressed the need for a dialogue between the centre and the Sindh government to settle the Rangers' issue.
The PPP leaders said their party strongly supported the National Action Plan and referred to Asif Ali Zardari's stand over it.
Modern-day dictator wearing the cloak of democracy. Got himself "selected"as the President of PPPP while his son is the party leader. What a joke!
First he have to come back and face the music!
Now PPP should be renamed to "Zardari and Company" it is no longer a People's Party.
Can imagine a self exile Sind Parlament President Asif Ali Zardari attending parliament's meeting via Skpes from Dubai. May be people of SIND should let all parliament members move to Dubai utill all the dust settle down.No one will miss them.
AAZ is obsessed with money and only money. He doesn't care about governance, PPPP, interest of common man, his family or anything else. His obsession with money is so strong that he is not going to change, period ! His followers know this fact very well. But again it serves their vested interest that they support him.
It is Zardari and family (Bilawal, Bukhtawar, Faryal Talpur's) party anyways. Making Zardari President or secretary or anyone else doesn't make ANY difference to anything. This gang will go on and on to rule the people of Sindh for at least a century in the name of 'Bhutto'.
Go ahead and further decimate the party you infected.
Wake up............. it was just a democracy dream!
Son Chairman of PPP, father President of PPP, what a laughing disgusted party.
True leader of corrupt gang.
These so called leaders like caira and aitezaz have no guts to stand up. PPP is a dead horse. PML N incompoops must be rejoicing.
I just fail to understand how a certified corrupt person can be given such high profile place in a party.
I am very glad that finally zardari took this decision, now the bhutto name is no more there and peoples party die heart workers will apart themselves. The group of thieves will have very less support and it will be easy for our security agencies to take action against them.
They are all that way, Zardari, Nawaz, Imran Khan - all elected to the chief post without an election.
Good I hope we see you back in president house soon. Bilawal PM and you President. That's how Pakistan will prosper. PPP Jiyala.
If Nawaz family & his company holds the reins of party and enjoys power uninterrupted, why not Zardari becomes the president of PPPP? If we recognize democracy only politcal system in Pakistan than we also should democratic attitude which seems missing in our lives. Long live democracy.
Great. Is seems father president son PM sister CM..,oh wait few posts are lying vacant...where is my daughters??? Democracy shouldn't be derailed.


Antigua, fondly known as the 'heart of the Caribbean', is a dream holiday destination. Its coastline features 365 stunning beaches and is almost completely surrounded by spectacular coral reefs providing beautiful diving and snorkelling sites. With a different beach for each day of the year you'll be spoilt for choice!
Antigua is a great choice for travellers of all interests, from beach fanatics with its deeply cut bays and dazzling white sand, to history lovers with Nelson's Dockyard National Park, one of the eastern Caribbean's biggest attractions and the world's most visible symbol of England's naval heritage.
Experience a unique eco-tour through Antigua's lush rainforest where you can embark on an unforgettable journey through the verdant forest, high above the trees. Make sure you head to the capital, St. John's, on a Saturday morning to experience the sights, sounds and smells of the market as you explore the colourful stalls and handcrafts, there's duty free shopping too!
Factor in the cultural delights and friendly locals and your slice of Caribbean paradise is waiting to be explored. Although Antigua is one of the quieter Caribbean islands, you won't be short of things to do – the glittering coastline and crystal blue waters will leave you dazzled and longing to return.
Take in the views from Shirley Heights – With a barbecue, drinks and local bands, this spot is great on a Sunday evening to enjoy the sunset and views of English Harbour and the coast.
Visit Stingray City – Hop on the D-boat, a retired oil tanker turned party boat and waterpark, to soak up the sunshine. Enjoy lunch on board and take a ride out to Stingray City where you can pet and feed southern rays in shallow clear waters, rated the top experience in Antigua by Trip Advisor.
Barbuda day trip – Visit Antigua's exotic sister island Barbuda for a day to remember! Explore Frigate Bird Sanctuary and learn about the wildlife on Barbuda, followed by lunch and some beach time.


On today's edition of Southeast Texas Senior Entertainment, we look at a unique program offered by Moody Gardens in Galveston.
Moody Gardens is a true treasure for the whole Gulf Coast. As Southeast Texans, we're lucky to have Moody Gardens practically in our backyard.
However, for some seniors even a short car and ferry ride is no longer convenient.
Moody Gardens does offer a wonderful outreach program that is a great fit for East Texas and Golden Triangle senior centers, clubs, and even nursing homes. Essentially, you can schedule a "Rainforest Roadshow" and a Moody Gardens expert will visit you and bring artifacts for a true hand on learning experience.
Programs start at $100 (call to verify the price for your area).
This is a great option for nursing homes, senior living facilities, senior centers, and church senior ministries.
The "Rainforest Roadshow" can even be great option for very active seniors. When you start to add up the cost of taking a group of seniors to Moody Gardens- vehicle rental, gas, food, tickets, it can be pricey for many seniors. This is a low cost alternative, letting you get the hands on experience without leaving Southeast Texas.
Reservations for the Rainforest Roadshow must be made at least two weeks ahead.
We hope today's edition of Southeast Texas Senior Entertainment has been helpful.
Are you looking for more senior fun in Southeast Texas?
Stay tuned – or "Like" SETX Seniors on Facebook and receive updates directly to your cell phone or tablet.


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News & Articles By Ethan Huff
Just in time for Christmas, parts of Europe enter extreme COVID-19 lockdown
Hoping to escape in enough time to avoid the new "Tier 4" Wuhan coronavirus (COVID-19) restrictions that were just implemented, Londoners were seen right before Christmas making a mass exodus from the city. Because of a new supposedly more contagious strain of the Chinese Virus, U.K. Prime Minister Boris Johnson ramped up the tyranny by […]
COVID-19 vaccines may increase the risk of HIV infections
Some of the Wuhan coronavirus (COVID-19) vaccines currently in development could increase recipients' risk of developing HIV infection, a new study published in The Lancet suggests. Researchers say efforts to create an HIV vaccine more than a decade ago did the same thing, and now it is happening all over again as governments and drug […]
Colorado congressman more worried about vaccine than COVID-19
President Donald Trump's "Operation Warp Speed" vaccines for the Wuhan coronavirus (COVID-19) have arrived, but not all politicians, including some Republicans, are interested in getting one due to the risks involved. Rep. Ken Buck, a Republican congressman from Colorado, told Fox Business host Neil Cavuto the other day that he is "more concerned about the […]
VACCINE EUGENICS: Elderly Americans should not be first in line for COVID-19 vaccine because they're "too white," claim medical experts
For months, we have been told that the elderly, the immunocompromised, and those who work on the front lines in essential sectors would be the first to receive the Wuhan coronavirus (COVID-19) vaccine. However, some medical experts are now claiming that old people should wait a little while longer because they are "too white." According […]
Whistleblower who exposed COVID-19 vaccine side effects slapped with lawsuit
A 40-year-old Indian man is being sued by the Serum Institute of India (SII) for going public with gory details about the horrific side effects he experienced following vaccination for the Wuhan coronavirus (COVID-19). The man had been participating in a clinical trial for an experimental COVID-19 vaccine when he suffered a "neurological and psychological" […]
SKIN COLOR MEDICINE: Half of U.S. States prioritizing Blacks, People Of Color for COVID-19 vaccination
People considered to be "non-white" are being given top priority for Wuhan coronavirus (COVID-19) vaccination in at least 25 states, new reports indicate. In order to achieve what Bill and Melinda Gates have described as an "equitable" distribution of China Virus jabs, half of America is prioritizing people with black and brown skin, sending them […]
On Dec. 16, just a few days after President Donald Trump's "Operation Warp Speed" Wuhan coronavirus (COVID-19) vaccines were unveiled and unleashed, Twitter made an announcement that it has begun to "prioritize the removal of the most harmful misleading information" about the dangers and ineffectiveness of the jabs. In addition to labeling tweets "that contain […]
Believe women … unless they tell the truth about vaccines, then label them "conspiracy theorists"
Conservative pundit Candace Owens is making waves over some comments she made questioning the safety and effectiveness of vaccines, including the new Wuhan coronavirus (COVID-19) jabs. Owens had a "terrifying" experience of her own after receiving Merck's controversial Gardasil vaccine for human papillomavirus (HPV). The jab "forever altered" Owens' thinking about vaccines in general, though […]
Mike Pence gets fake vaccinated on live television to promote warp speed vaccines
On Friday, Vice President Mike Pence along with his wife Karen Pence pretended to receive a Pfizer-BioNTech Wuhan coronavirus (COVID-19) vaccine on live television in an effort to reassure the American public that the jab is "safe and effective." The reason we say pretended is that video footage of the spectacle (see below) depicts a […]
Democrat Andrew Yang wants to barcode you like a Nazi concentration camp prisoner, forcing you to prove you've been vaccinated
Failed presidential candidate Andrew Yang announced on Twitter the other day that he thinks all Americans need to be assigned unique "barcodes" showing that they have been vaccinated for the Wuhan coronavirus (COVID-19). The Taiwanese businessman says that instead of giving people paper vaccination cards as proof of compliance, the government should issue a digital […]
Health.News is a fact-based public education website published by Health News Features, LLC.
All content copyright © 2018 by Health News Features, LLC.
Contact Us with Tips or Corrections
All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.


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Better joints without surgery
by release January 16, 2013 July 22, 2015 037
People have a higher likelihood of ending up disabled from arthritis if they're sedentary, according to Consumer Reports. Photo courtesy of Consumer Reports
Americans are wearing out their joints, Consumer Reports notes. Knee replacement is now among the most common major surgeries, up 162 percent in the last two decades, according to an analysis of Medicare data published in the Journal of the American Medical Association.The increase is partly due to the population growth of aging baby boomers. It also reflects rising rates of obesity and the fact that a more active group of people is unwilling to live with the pain and disability of osteoarthritis.
Surgery to replace joints is a good option if your condition has become disabling, but it's possible to delay or prevent the need for surgery. Consumer Reports offers this roundup of evidence-based approaches that can help protect joints and minimize the painful symptoms of arthritis.
— Achieve a healthy weight. Being overweight increases the stress on joints and might even hasten the breakdown of cartilage. Obesity can have systemic effects that are not well understood. Research suggests that it even increases the risk of developing arthritis in joints that don't bear weight.
Fortunately, even modest weight loss — as little as 5 percent of body weight — has been shown to reduce the risk of arthritis later. Research suggests that losing weight reduces pain in people who already have the disease.
— Stay active. Because osteoarthritis can arise from the overuse of joints or sports injuries, some people who have the condition worry that exercise will make it worse. In fact, the opposite may be true. Limited evidence suggests that routine physical activity is linked to healthier cartilage in the knees, according to a 2011 review of 28 studies. People have a higher likelihood of ending up disabled from arthritis if they're sedentary.
— Treat injuries promptly. Left untreated, injuries such as a small tear in the knee cartilage or a shoulder tendon can set in motion a wear-and-tear process that leads to joint deterioration. See a doctor for any injury that causes severe pain or swelling, or minor pain that doesn't resolve after a week or so. Take steps to minimize the risk of injury in the first place. For example, don't wear running shoes, which are designed to keep your weight from shifting sideways, to play tennis.
— Consider nondrug options. Finding effective ways to alleviate pain, swelling and stiffness is critical to staying active. Many people find that one or more of these nondrug measures can reduce the need for pain medication: acupuncture; heat and cold, including moist heating pads for stiff joints and ice packs for acute pain and swelling; massage; and mechanical aids such as a cane, crutch or walker.
— Simplify drug treatment. Newer, heavily advertised name-brand drugs such as duloxetine (Cymbalta) — which is approved for treating chronic musculoskeletal osteoarthritis pain — often don't work better than basic pain relievers, but they cost more and can carry a greater risk of side effects. Instead, start with a tried-and-true pain reliever, such as over-the-counter acetaminophen (Tylenol and generic). Consumer Reports also suggests talking with your doctor about the topical version of the NSAID diclofenac (Pennsaid and Voltaren Gel). Finally, shots of anti-inflammatory steroids are an effective short-term remedy for moderate to severe pain and swelling in the knees and hips.
— Use supplements wisely. Despite mixed evidence and a lack of support from major health groups about the role of the supplements glucosamine and chondroitin in treating osteoarthritis, some people think they help. But if you don't experience relief within three months, there's no point in continuing to take them.
— Skip unproven treatments. In particular, the most recent data suggests that injections of hyaluronic acid (Synvisc) directly into a joint, known as viscosupplementation, isn't worth the risk. In an Aug. 2012 review of 89 clinical trials involving more than 12,000 patients, the authors concluded that viscosupplementation did little or nothing overall to relieve pain or increase function in people with knee osteoarthritis.
EncinitasShare0
Composite sketches of home invasion suspects released
A transformative four-day cleanse with Beaming & the bAR
Understanding tricky food labels
release August 14, 2013 July 22, 2015
Survey: Mobile phone service improving
by.the.editors.of..consumer.reports December 18, 2008 July 20, 2015
Getting that zing back
the.editors.of..consumer.reports. May 8, 2009 July 20, 2015
Cream of the icy summer treats
editors.of.consumer.reports July 16, 2010 July 20, 2015
Planet- and budget-friendly products that really work
editors.of.consumer.reports April 9, 2010 July 20, 2015
3D TVs boast some seriously sophisticated hardware
consumer.reports February 17, 2011 July 20, 2015


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Q: R replace logical vector with "on" or "off" I'm trying to create a one liner that will replace a logical vector with "on" or "off" based on true or false.
Best I've been able to come up with is using 2 gsubs.
Assuming I have the vector tmp
tmp <- sample(100,100)

I can use
blah <- tmp > 50
blah <- gsub(FALSE, "no", blah)
blah <- gsub(TRUE, "yes", blah)

to achieve what I want, but I'm betting there's a more elegant solution.

A: Try
r1 <- c('no', 'yes')[(tmp>50)+1]
identical(r1, blah)
#[1] TRUE

Or
 r2 <- as.character(factor(tmp>50, labels=c('no', 'yes')))
 identical(r1, r2)
#[1] TRUE

Or
 library(qdap)
 r3 <-  mgsub(c(FALSE, TRUE), c('no', 'yes'), tmp > 50)
 identical(r1,r3)
 #[1] TRUE

Or
 library(car)
 r4 <- recode(tmp>50, "FALSE='no'; TRUE='yes'")
 identical(r1,r4)
 #[1] TRUE

A: using ifelse:
blah <- ifelse(tmp > 50, "yes", "no")

redpajama_set_name: RedPajamaStackExchange


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For EV Drivers
GreenWay installs 31 HPC stations in Poland
Greenway networkMedia about usGreenWay installs 31 HPC stations in Poland
GreenWay will be opening a series of 31 fast charging stations across Poland during July and August. The move will expand the company's presence in Poland and Slovakia to around 100 charging stations.
So far, GreenWay owns 33 stations in Poland and another 30 stations in Slovakia. The infrastructure expansion will enlarge the network by around a third. The first 30 days after the stations go live will be free of charge. The expansion is also being funded by an EU project named Connecting Europe Facility (CEF). The locations will belong to the Trans-European Transport Network (TEN-T) after completion.
In January, GreenWay made headlines with the installation of a so-called GridBooster System for EVs. The system was installed at a shopping mall in Bratislava, and, according to GreenWay, is the first battery-supported fast charging system for EVs in eastern Europe.
electriccarsreport.com
25. July
Electrive.com
4. February
27. June
Greenway Infrastructure to bring Ultrafast & Battery Assisted Electric Vehicle Charging to Central Europe & expand fast charging network
COPYRIGHT 2019 © GreenWay Infrastructure s. r. o.
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Q: How to match strings that aren't entirely digits (actually more complicated)? I have this RegExp:
(?<=:)(?:(?!null|false|true)[\w\-])+(?=,)

The goal is to match all strings between : and , as long as they are not equal to null, false, or true.
Here is the test string:
ids:[\"123\"],name:null,value:false,prop:true,Quantity:8d-1,number:123,name:\"hello\",id2:\"1234\"

The matches are 8d-1 and 123.
How do I exclude matches that are entirely numbers, like 123?

A: You could use assert what is on the right is not one of the alternatives followed by a comma without using the quantifier for the group.
Then match [\w-]+ and assert a comma at the right.
(?<=:)(?!(?:null|false|true|\d+),)[\w-]+(?=,)

*

*(?<=:) Positive lookbehind, assert a : directly to the left

*(?! Negative lookahead, assert what is directly to the right is not

*

*(?:null|false|true|\d+), Match one of the alternatives followed by a comma

*) Close lookahead

*[\w-]+ Match 1+ times a word char or hyphen

*(?=,) Assert a comma at the right

Regex demo

const regex = /(?<=:)(?!(?:null|false|true|\d+),)[\w-]+(?=,)/g;
const str = 'ids:["123"],name:null,value:false,prop:true,Quantity:8d-1,number:123,name:"hello",id2:"1234"';
console.log(str.match(regex));


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Q: MS ACCESS-Way to normalize Inventory Data I have a simple inventory database and I'd like some conceptual help.
Right now I use one table to store all of the items. Here's the problem I run into, Lets say I have 100 of a certain item, Normally I'd just store it as 1 item with quantity being 100. However, if its a high value item with serial numbers, I have to store it 100 times, each with a unique information (serial number, expiration date,Id Number, ETC.) Is there a better way to normalize this? maybe through the use of a another table? My main concern is that when I try to display all the items in a simple datasheet style form I run into huge numbers of these basically duplicate entries, is there a way I might just combine them in a query then have them all display as 1 item with quantity being the number of duplicates then have a sub sheet that I can click to view each serial number, expiration date and etceteria or should I just bite the bullet and leave it be. anyone else have a suggestion for me? Thanks guys.

A: I have something similar in a tooling and equipment tracking database.  First you are on the right track with having multiple tables.  How I have it is one table for the item and one table for the manufacture information.  I can have multiple items per a single manufacturer.  There is a one to many link between the Manufacturer and the Item.
In your case you would want to have one table for the general item information and one for serial numbers.  You could either link them by a unique auto numbered key field or by item number.  For ease of use I prefer linking by item number but others would argue that an integer (the auto numbered field) may provide faster results.
As to displaying them you could either create a query that shows them line by line with each serial number or you could do a Form/Sub Form combination to show the single item on the main and the serial numbers on the sub.
Also when you set up the relationships on the table and you open the main item table it will automatically show you that there are linked sub tables and you can expand them to view that data.
I hope this is helpful.


I am … a historian and a sociologist, the director of the Radovljica Municipality Museums (consistin of Municipal Museum of Radovljica, Museum of Apiculture, Šivec House, Museum of Hostanes, Iron Forging Museum). Working in a small community demands a lot of persistance and good organizational skills, which I might have gained through the active sport career in my youth. I really do like my work, which is also my way of life with the support of my already grown-up family.
In diStory project … I confront with a new way of work organization and young colleagues, who bring freshness and new horizons to the team. My role in diStory Radovljica is collecting content, active inclusion of local community and working with different audiences.
diStory project … is a great chance for mutual communication, sharing knowledge, cooperation with people and searching for innovative approaches towards presenting our interesting stories to the others. Since we are the leading partner of the project, I also see it as a great responsibility.
In June 2018 … the project will be finished. We will have an interesting experience of learning and ultidisciplinary work behind us. We'll be glad to upgrade it in the future.
The future … of the museums is local activity, yet within an international scope.
I am … an architect with daily different colourful earrings, who likes running. I don't wear them at home because my child doesn't like them. Adjustable, flexible, adaptable. Connected. Responsible. Diplomatic. Sometimes with sparks in my eyes.
In diStory project … I am responsible and friendly. A friend. Sometimes a bouncing bag. A medium for EVERYTHING and EVERYONE.
diStory project … is a challenge. New era school. Infinity of new, that encourages me to search and re-search. An opportunity to step up and present. To show what I can do and find out what I can't and learn. Is communication. Setting reasonable boundaries and appreciating yourself and the others.
In June 2018 … we will meet with diStory friends on Linhart Square and put the cherry on the top of our cake. We will spread our circle and give hands to all the people who live in small historical towns showing them we can be big. We will also write the final report.
The future … is tomorrow. We create it today.
I am … Katja Praprotnik, a history and sociology teacher by profession. I worked in Museum as a student; I was a guide first, then a museum educator and today I am the curator of the Municipal Museum of Radovljica. I am also a mum, house-wife when needed, a fan of trekking, running and skiing. I love different cultures … and cats.
In diStory project … I collect stories and I enjoy doing it. I am aware of hidden treasures of our small historic town and I would like to uncover them.
diStory project … is a big challenge for a small museum with only few employees. The project brought us new digital technologies that we are unjustifiably afraid of and for which we think that only belong to our children, to youth.
In June 2018 … will not be easy, because we will organize the final meeting of all project partners. We will manage it. With good weather, which will attract crowds of people on the Linhart's Square.
The future … is to discover new old stories of Radovljica city.
I am … offically a museum educator at the time being, but also a film educator, soft skills trainer and a volunteer. Open-minded and willing to learn something new every day.
In diStory project … I am especially interested in »community management« aspect. Communication with different audeinces, active participation. When I hear about »audience development« lots of questions pop up my mind. What actually is »audience«? What is »development«? How about »non-audience«? Who dictates the rules of the »participation«? Still looking fort he answers, though.
In June 2018 … the project will be finished. We will gather for the one last time in Radovljica and our final product will be launched. We will be spending a warm summer evening in our old city centre and people will pat us on the shoulders. Then we'll go home. Some of us will start looking for a job again, whilst millions of tourists will be exploring our long forgotten towns.
The future … is digital!


Let me give you the stories of two women who are very close to me, both of whom start our tales with children from previous relationships. Both met men they thought would be perfect dads and perfect husbands. One said, "you don't touch me unless you're willing to commit to being the father for my child. We're a package deal, and I won't hurt my kid by investing in you if it's not for real." The other let the man dictate the terms. The first woman is married with more children, and they're a very happy family. The second is still dating that same man, seven years later, with no real future in sight.
Too often we women act in ways that jeopardize our long-term happiness because we're scared of being alone now. And being alone is a big fear for lots of women. Indeed, our main priorities in life are relationship based: surveys show we want to love and be loved, we want to have an intimate relationship with a man, and most of us want children.
Yet if you look at today's generation of women, we're doing things that lessen the possibility of attaining these dreams, just like my second friend did in my example above. If you think of basic economics, it's easy to see how this works. The nature of supply and demand says that if there is a large supply of women who are willing to enter into relationships without any commitment tied to it, then the number of men who are willing to commit will correspondingly drop, because men have not historically yearned for commitment in the same way that women have.
As the lack of commitment in relationship becomes the norm, women who want commitment may think they have to settle for lack of commitment in the hopes that they can win the men over. When surveys of cohabiting couples are taken, for instance, the biggest conflict is often between those who want the relationship to progress and those who simply want it to go on as it is. Yet once you have entered into that kind of a relationship, you give up all your cards.
I know of another woman, let's call her Mary, who began dating a man when she was 26. She is now 42, and has finally broken off the relationship when she realized he was never going to marry her. But now she is completely devastated, because she also realizes that she has lost her chance to have children. She wasted sixteen years of her life, and the best years at that, on this man who wasn't really interested in anything long-term. She knew his views from the very beginning, but she just kept hoping she could change his mind.
Once you're in the emotional roller coaster of a relationship, it's hard to get off, even if you can see objectively that it's self-destructive. That's why Mary stayed so long. It's probably better to start a relationship with a game plan, just like my first friend did, so that you can avoid that roller coaster. And what is that game plan? It means not investing in someone who isn't willing to invest in you. It means valuing yourself, and your current and future children, enough to say I would rather be alone than be with someone who doesn't want me for good. It means being comfortable enough to throw some relationships overboard, even if he does seem like a great guy. It means channeling Shania Twain, when she said if you're not in it for life, I'm outta here.
If you want to be with someone who loves you, then don't settle for someone who doesn't just in the hopes you can change him. And if he says he loves you, but he doesn't want commitment, or children, and you do, then that love isn't enough. Real love isn't temporary. It lasts, and if a guy doesn't want the love to last, then you deserve better. If you want real love, then don't settle for anything less. The more you do, the less chance you have of ever finding it.


PTXGs can recapitulate the wide spectrum of molecular traits consultant of their underlying main cancers this addresses the worries of not locating the inter-tumor heterogeneity required to build individualized drugs methods to remedy and PTXGs respond to pharmacologic therapy stably across numerous passages. Hence, we evaluated the likely of E/GEJ PTXGs to replicate what is found clinically in human E/GEJ tumors, and the circumstances in which these PTXGs are suitable to use as pre-medical drug screening models. Regardless of these conclusions, the genetic basis for S. mutans VicRK-modulated anxiety tolerance is not nicely-understood and the sign that encourage VicK activation continue being mysterious. Therefore, an enhanced knowing of how VicRK modulates these a variety of tension responses by means of gene expression could supply perception into how bacterial TCSs may possibly be manipulated, thereby fostering the growth of therapeutics towards bacterial bacterial infections. In the current study, we report that S. mutans VicK can transphosphorylate not only its cognate RR, VicR, but also the orphan RR, GcrR the latter is only demonstrable in vitro in the existence of manganese. We also display that whilst autophosphorylation and transphosphorylation reactions ended up increased by manganese, the specificity for a given RR appears distinct for just VicR and GcrR. In addition, we present proof to help a role for each VicK and SloR in gcrR transcriptional manage. Finally, we present that the DNA binding internet sites of VicR and GcrR overlap in frequent downstream gene promoters even more integrating the two RRs. A model is proposed for the organic basis for cross-chat between VicK, VicR and GcrR. In this report, we demonstrate that in vitro autophosphorylation of the S. mutans VicK HK is improved by manganese and inhibited by ferrous iron, suggesting two potential roles for VicRK in sensing manganese availability and situations of redox. We additional show that VicK, in addition to phosphorylating its cognate RR, VicR, facilitates in vitro cross-discuss by phosphorylating the orphan RR GcrR, in the existence of manganese albeit only when VicR is present at comparatively minimal relative concentration. Our results are related to people of Guckes et al who report comparable cross speak in the form of 1 HK getting capable to transphosphorylate certain non-cognate RRs, but only under particular circumstances. Whilst VicK-facilitated phosphorylation of VicR and GcrR appears to be distinct in vitro, it continues to be to be seen to what extent this phenomenon takes place in vivo. Apparently, Stipp et al just lately demonstrated that VicRK and GcrR function in concert to form structurally steady biofilms by coordinating area biogenesis and mobile division in S. mutans. Nonetheless their model did not show any immediate interaction between VicK and the orphan RR GcrR. Liang et al recognized a CovS mutant in S. pyogenes that retained CovR-mediated virulence gene regulation, by way of an unidentified alternate pathway for CovR phosphorylation. Right here we give perception into the conversation pathways of the S. mutans SloR, VicRK and GcrR regulators. Cross-regulation of GcrR by the VicK sensor kinase, could make clear the overlap in between the VicRK-regulon and that of GcrR, in modulating genes whose items contribute to the oxidative pressure and acid tolerance responses of S. mutans. Work carried out previously by Dunning et al showed that SloR interacts directly with the gcrR promoter area to facilitate its expression. Listed here we show that SloR also positively regulates expression of the vicRKX operon, but regardless of whether its effect on vicRKX transcription is immediate or oblique remains to be established. In addition, CAT-certain exercise observed in the S. mutans cat fusion strains support gcrR expression that is matter to equally SloR and VicRK manage. Final results of phosphorylation assays emphasize a role for manganese in integrating the VicRK, GcrR and SloR regulatory pathways. Manganese is an vital micronutrient that impacts S. mutans genes whose goods are conducive to its virulence, which consist of these that mediate adherence and biofilm formation. In fact, manganese functions as a cofactor for a S. mutans superoxide dismutase, which converts harmful reactive oxygen species, into significantly less toxic substances.


text:
Q: What is unit jω? I have an equation, from which I'm calculating the induced voltage received by an RFID tag antenna. I know that \$ω\$ = angular velocity, but what is \$jω\$?
And if \$jω\$ is related to angular velocity, what value I should give it, since my system is stationary and there isn't any movement.
Equation of induced voltage at receiver antenna is
$$
V_{ind} = NR_{x} · \mu_0 ·AR_x · jω · H
$$

A: Induced voltage at receiver antenna Vind = NRx · µo ·ARx · jω · H
The "j" is telling you that the voltage induced is 90 degrees leading the H-field. This ultimately comes from this basic Faraday law: -
$$V = -N\dfrac{d\Phi}{dt}$$
\$\Phi\$ is the magnetic field produced by the H-field.
"j" is what is known as the complex operator. In math circles they use "i" but EEs like to use i to represent current so j is used.

A: It's just \$j·ω\$. Electrical engineers use \$j\$ to represent the imaginary unit since \$i\$ is already used for currents.

A: \$ j \omega \$ can also be written \$j \cdot \omega\$ to show that it actually two things multiplied together.
\$j = \sqrt{-1} \$ and thus is unit less. It is an imaginary number and can be thought of as CCW rotation of \$90\$ degrees.  This is useful to simply calculations in passive AC circuits.  In pure mathematics \$ i \$ used in stead but this could be confused with current in electronics.
\$  \omega = 2 \cdot \pi \cdot f \$ the angular frequency measured in \$ \text{rad} \cdot \text{s}^{-1} \$.
Because \$ j \$ is unit less, \$j\omega\$ has units \$ \text{rad} \cdot \text{s}^{-1} \$.


This volume, published in 1968, was the first critical study of Persius in English. Unjustly squeezed from students' reading by the satiric giants Juvenal and Horace, Persius has often been regarded as 'difficult' or 'minor' and marginalized, condemned to 'the schooldust of the ages' by the repeated editing of traditional scholars (Clausen, Kissel). What Dessen offers is a close reading within the framework of the new criticism which led classics in the 1960s. She empasises the distinction between 'persona' and poet and argues that Persius' Satires, far from being just 'difficult', are unified and comprehensible through their controlling metaphors, their dominant imagery and word-repetition. In the heady days of post-structuralism, Dessen's approach, pioneering in its way, remains a beacon of stimulating poetic appreciation and one in which students and scholars of Persius will find a sound basis for their further work. A new elegant Foreword by Kenneth Reckford places Dessen's work in its critical context.


text:
Carriera
La sua prima introduzione al mondo dei fumetti è stata quando da bambino è stato portato dai genitori alla biblioteca di Framinghan in Massachusetts e avevano delle raccolte di comic strip (ovvero strisce a fumetti). La sua attenzione è da subito attirata dalle celebri strisce umoristiche Calvin and Hobbes di Bill Wattersons. Divenne da subito il suo fumetto preferito di cui si lesse tutte le raccolte. Le sue vicende preferite sono quelle in cui i protagonisti si trovano in realtà alternative, specialmente quelle con i dinosauri. I primi fumetti che si ricordi di aver disegnato sono stati quelli ispirati alla sua serie tv preferita ovvero i Power Rangers. Tra l'altro la sua passione per il disegno e le storie nate dall'immaginazione è favorita dal  triste fatto che ha un carattere introverso che lo porta ad essere un solitario, i suoi compagni di classe non lo invitano neppure ai loro compleanni. Sviluppa una profonda avversione per la Scuola e i genitori sono costretti a tenerlo a casa già dalla seconda elementare dove gli viene impartita un'istruzione in casa sua da insegnanti privati. Dopo le scuole dell'obbligo comincia a frequentare dei corsi presso una Scuola d'Arte dove trova un insegnante di origine italiana di nome Rosetta che ne intuisce il talento e la passione. Il suo principale insegnamento e assioma valido per ogni artista è :«Disegna ciò che vedi e senti (cosa dovrebbe rappresentare attraverso la tua percezione). Non disegnarlo come ti appare (o come gli possa somigliare a livello fotografico)». La sua passione lo porta a rivalutare l'insegnamento e l'istruzione e si iscrive al College di Chicago dove ottiene una laura che gli permette di diventare un insegnante di d'Arte. Purtroppo dopo qualche anno si accorge che non glli piace essere un professore e non sta sviluppando la sua creatività e quindi lascia un sicuro posto di lavoro. Nonostante gli piaccia disegnare i super eroi e all'inizio quello su cui prerisce esercitarsi è Hulk (della Marvel Comics). Nonostante questo non crede sia possibile o comunque molto difficile inserirsi in questo settore che è molto competitivo e già saturo di dsegnatori talentuosi ed esperti. Nonostante questo si fissa una finestra di tempo di 3 mesi in cui si dedica ad un lavoro part time in un Ospedale dove porta le barelle e i lettini aiutando le persone portatrici di handicap. Nel resto della giornata cerca di passare più tempo possibile a scrivere e disegnare per diventare un fumettista autodidatta. Se dopo la scadenza che si è dato non dovesse riuscire a pagare l'affitto o mantenere una vita dignitosa allora tornerà alla professione di insegnante d'arte. All'inizio del secondo decennio degli anni duemila si dedica a scrivere e disegnare la sua prima opera ovvero Space Mullett ma nessun editor gli da fiducia per una pubblicazione cartacea quindi decide di trasformarla in un web comic e diffonderla su digital comics. A quel punto il presidente della Dark Horse Comics Mike Richardson si accorge di un certo talento e originalità dell'autore, un'intuizione che in passato gli ha permesso di lanciare sul mercato indipendente giovani promesse poi diventante (in taluni casi) delle star del settore. Richarson decide di affiancargli un altro autore debuttante quale il texano Donny Cates con il quale producono un'opera originale e innovativa quale Ghost Fleet che però risulta essere un flop (inizialmente) presso critica e lettori. La serie viene anche sospesa. Tale insuccesso non favorisce i due fumettisti che però sono entrambi destinati a diventare autori top-seller del settore. La stessa Ghost Fleet viene col tempo rivalutata (dopo il 2018) e arriva ad avere anche un'edizione internazionale tra cui SaldaPress in Italia dal novembre 2019.

Attivo come fumettista e illustratore di copertine, vive e lavora a Chicago. Ha collaborato con le più importanti case editrici tra cui Marvel Comics, DC Comics, Dark Horse Comics e Image Comics. Ha suscitato l'interesse del settore in seguito alla diffusione via internet del web-comic Space Mullet, pubblicato nel 2016 dalla Dark Horse. Ottiene popolarità e consenso della critica con la serie Extremity, pubblicata dall'imprint Skybound della Image Comics, per la quale ottiene una nomination agli Eisner Award. Tra le sue altre opere vi sono: The Ghost Fleet, Murder Falcon, Wonder Woman: Dead Earth (per l'imprint DC Black Label).

Opere

Dark Horse Comics
Eve: True Stories, Daniel Way (testi) - Alejandro Aragon, Daniel Warren Johnson, Federico Dallocchio (disegni), graphic novel, storie spin-off dal pluripremiato video game EVE Online, 11 giugno 2014.
The Ghost Fleet nn. 1-8, testi di Donny Cates, miniserie, novembre 2014 - giugno 2015
Alabaster: The Good, The Bad and The Bird nn. 1-5, testi di Caitlín R. Kiernan e disegni di Daniel Warren Johnson (disegni), miniserie di 5 albi (conclusa), dicembre 2015 - aprile 2016
Space Mullet: One Gamble at a Time, testi e disegni, raccolta in volume brossurato (o trade paperback) del web-comic Space Mullet. Contiene le storie serializzate tra il 2012 e il 2014. Distribuito nel 2016.

DC Comics
 Sinestro Annual n.1, Cullen Bunn (testi) - Daniel Warren Johnson & AA.VV. (disegni), albo annuale, 1 aprile 2015.
 Wonder Woman: Dead Earth nn. 1-4, testi e disegni (Daniel Warren Johnson), limited-series (conclusa), etichetta: DC Black Label, febbraio 2019 - ottobre 2020.
 Superman: Red and Blue n.5, Daniel Warren Johnson & AA.VV. (testi e disegni), albo antologico contenente 5 short-story di 8 pagine di cui Johnson realizza testi, disegni e colorazione della storia intitolata Ge22nerations, limited-series  (conclusa), settembre 2021.
 Batman: Black and White (Vol.2) n.4, Daniel Warren Johnson & AA.VV. (testi e disegni), albo antologico contenente 5 short-story di 8 pagine di cui Warren realizza la storia Checkmate, miniserie (conclusa), maggio 2021.
 The Jurassic League nn.1-6, Daniel Warren Johnson (testi e copertine alternative), Juan Gedeon (testi,disegni, copertine regolari), limited-series di 6 albi (conclusa) con protagonista una versione alternativa della Justice League of America, 11 maggio 2022 - 11 ottobre 2022.

Image Comics
Extremity nn. 1-18, Daniel Warren Johnson (testi e disegni), serie regolare, marzo 2017 - marzo 2018
Murder Falcon nn. 1-8, Daniel Warren Johnson (testi e disegni), miniserie, ottobre 2018 - maggio 2019
Head Lopper n.13, Andrew McLean (testi, disegni, copertina) - Daniel Warren Johnson (Copertina alternativa o Variant Cover), data di distribuzione: 16 settembre 2020.
Skybound X n.3, Daniel Warren Johnson & AA.VV. (testi e disegni), miniserie antologica di cui Johnson realizza una storia correlata (side-story) alla miniserie Murder Falcon, data di distribuzione: 21 luglio 2021.
Do a Powerbomb dal n.1, Daniel Warren Johnson (testi e disegni), miniserie di 7 albi, distribuita dal 15 giugno 2022.

Marvel Comics
 Quake: S.H.I.E.L.D. 50th Anniversary n.1, Patrick Kindlon e Matthew Rosenberg (testi) - Daniel Warren Johnson (disegni), albo unico celebrativo, novembre 2015.
 Man-Thing (Vol.5) n.1, contiene 2 storie: Whoever knowns fear Burns the touch (20 pagine), R.L.Stine (testi) - German Peralta (disegni) / R.L.Stine (testi) - Daniel Warren Johnson (disegni) (short story di 10 pagine, maggio 2017.
 Beta Ray Bill nn. 1-5 , Daniel Warren Johnson (testi e disegni), limietichettated-series (conclusa), maggio 2021 - settembre 2021.
 Deadpool: Black, White & Blood n.2, Daniel Warren Johnson & AA.VV. (testi e disegni), albo antologico contenente 3 storie di 10 pagine di cui Warren realizza la storia Checkmate, miniserie (conclusa), novembre 2021.

Premi e riconoscimenti
Ha vinto il Bram Stoker Award per la miniserie Alabaster: The Good, The Bad and The Bird pubblicata da Dark Horse Comics, assegnato alle opere di genere horror e dark fantasy pubblicate dai vari tipi di media.

Note


As soon as you have a moving date set, but before that if possible. Most removals companies are booked up weeks, often months in advance, so it pays to be super-organised.
How large a vehicle you need, the distance of your move, and the time of year will likely dictate just how far in advance you should secure the services of a removals company.
Removal costs can vary considerably depending on the type of move being undertaken, with overseas removals incurring high fees for shipping and insurance. We determine our fees based on the volume of effects being moved.
We will send you a free written quotation. If you are satisfied with our quote, we will then provide a full schedule, ensuring there are no nasty hidden surprises or undisclosed add-ons.
How can I arrange a free survey and quotation?
Simply give us a call or fill out one of our quick quote forms. Our surveyor will call round at a time convenient to you and will access factors such as the volumes of effects being moved, access to the property and any particular packaging materials needed.
Do you supply packaging materials?
We supply an extensive range of purpose-made packing materials to ensure your goods are packed away safely and securely for transit. In addition to standard boxes and packing materials, we also offer portable wardrobes, book cartons, wine dividers and acid free paper (for Silverware).
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As a member of BAR we offer our customers Standard Liability Insurance and pay a £250 excess on all claims, which covers goods in transit. Coverage for overseas removals may differ according to the form of shipping. All policies are subject to GoodMove Removals and Storage's terms and conditions.


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Difference between revisions of "1.21 Salvation"
MaryColt (talk | contribs)
|Pad_of_Definitions=
* [[Acting in Unison]]
* [[Aliases]]
* [[Carry On Wayward Son]]
* [[Rosary]]
* [[Sulfur]]
* [[Talking in Unison]]
* [[Telepath]]
* [[Tongues]]
Title Salvation
Episode # Season 1, Episode 21
First aired April 27, 2006
Directed by Robert Singer
Written by Sera Gamble
Raelle Tucker
On IMDB Salvation
Outline The Winchesters attempt to deal with demons and prevent the murder of another mother the way Mary died.
Monster Demons
Timeline Immediately after 1.20 Dead Man's Blood
Location(s) Blue Earth, Minnesota
Manning, Colorado
Salvation, Iowa
[[{{{prevep}}}|« Previous Episode]] | [[{{{nextep}}}|Next Episode »]]
6 Trivia & References
7 Minutiae
8 Sides, Scripts & Transcripts
In Blue Earth, Minnesota, a priest is reading the Bible at his altar when Meg enters, ostensibly seeking solace. The priest encourages her, as "Salvation is there for all who seek it." When she reveals her black eyes, the priest retreats in horror to an underground office fitted out with the tools of a Hunter, with research and runes spanning the walls. Meg follows him, kicking in the barred doors. He asks, "What do you want?" and she demands the location of John Winchester, who he refuses to betray. She slits his throat.
Back in Manning, Colorado, John is sharing his research of the last 20 years with Sam and Dean. He explains the trail he has followed and the telltale signs. Sam's guilt at being the cause of the deaths of both Mary and Jess turns into anger and pain. But neither John nor Dean allow him to wallow. John sees the signs starting again in Salvation, Iowa, and is intent on saving another family from the pain and loss suffered by the Winchesters.
On the road, John receives the news that Pastor Jim Murphy, the priest from the opening, has been murdered, probably by demons. John feels the pressure to hurry, to find the next family on the demon's list. In despair, John mourns his friend and states "This ends... now... I'm ending it. I don't care what it takes."
Overcome by the size of their task, they split up to cover more territory and research all infants turning 6 months old in the coming week. As Sam leaves the medical center where he has been reviewing birth records, he has a vision of the demon's next target. Following the signs in his vision, he meets the young mother Monica and her daughter, Rosie. Unable to warn her, he returns to Dean and John. John is angry that the boys hadn't told him before about Sam's visions. Dean points out John's unresponsiveness and angrily states he would have had better luck winning the lottery than reaching his father on the phone. John grudgingly admits that he's right. Interrupting, Sam's phone rings and Meg, who they thought dead, demands to speak with John. She informs him that she murdered Jim Murphy and is now with another friend, Caleb. She wants the Colt.
In desperation, John plays dumb and Meg promptly kills Caleb. She says she will keep killing all his friends until he hands over the Colt. Capitulating, John agrees to meet her in Lincoln at midnight for the trade. The boys protest handing the gun over, but John has a plan: they will use a substitute gun since Meg doesn't know what the real one looks like. In an emotional revelation, he admits again that he needs this job to finally be over. When Dean returns with the fake Colt, he pleads with John to not throw his life away, as he's no good to them dead. John tells them to do the same. He hands over the real Colt and the task of killing the demon to the boys, charging them with finishing the job he started.
John arrives in Lincoln to meet Meg. He cases the territory for escape routes and traps and finds a reservoir to bless. While the boys stand watch over Monica and her family, John confronts Meg. She is joined by a demon named Tom. John hands the gun to Meg and she in turn hands it off to Tom, asking if he thinks it's the real thing. Without warning, he shoots Meg. She's pissed but she doesn't die. In shock and anger, Meg rounds on John now that it is obvious the gun isn't the real Colt. He runs and deters them by releasing a valve, spraying them with the Holy Water he prepared earlier. Outside the building, John finds his truck's tires have been slashed. Running, he finds himself trapped in a dead end.
Meanwhile, seeing the house lights flicker and hearing static on the car radio, the boys recognize the signs that the demon is coming and they break into the house in attempt to save Monica and Rosie. Racing to the nursery, Sam faces the demon over Rosie's crib. He hesitates for a second before firing off a shot, but the demon vanishes too fast. Grabbing Monica as Dean saves Rosie, they run from the burning house. Dean stops Sam from trying to reenter the burning building to reach the demon.
Back at the hotel room, while Dean is anxiously trying to contact John, Sam is angry that Dean stopped him from going after the Demon. Dean confronts him about his desire for revenge and self-sacrifice, stating that if it means Sam getting himself killed, he hopes they never find it. Sam's anger boils over and he pushes Dean into an emotional confession. Shocking Sam into the present, his focus shifts back to John. Dean tries his father's phone again, it is answered by Meg and to their horror she promises they will never see their father again...
John Winchester
Pastor Jim Murphy
Monica Holt
Charlie Holt
Rose Holt
Acting in Unison
Carry On Wayward Son
The Colt
Dean's Amulet
Deer's Head
Fictional Locations
John's Cell Phone
Mandaic Amulet
Telepath
"Carry On Wayward Son" by Kansas
(plays during "The Road So Far" recap of events)
Meg: Well. I've lied. A lot. I've stolen. I've lusted. And the other day I met this man. A nice guy, you know? We had a really good chat, sort of like this... then I slit his throat and ripped his heart out through his chest... Does that make me a bad person?
Pastor Jim: I know what you are. You can't be here. This is hallowed ground.
Meg: Please. Maybe that works in the minor leagues. But not with me.
John: So this is it. This is everything I know. Look, our whole lives we been searching for this demon right? Not a trace, just... nothing. Until about a year ago. For the first time I picked up a trail.
Dean: And that's when you took off.
John: Yeah. That's right. The demon must have come out of hiding, or hibernation.
Dean: All right so what's this trail you found?
John: It starts in Arizona, then New Jersey, California. Houses burned down to the ground. It's going after families, just like it went after us.
Dean: All right so how do we find it... before it hits again.
John: There's signs. It took me a while to see the pattern but it's there in the days before these fires signs crop up in an area. Cattle deaths, temperature fluctuations, electrical storms. And then I went back and checked... and...
Dean: These things happened in Lawrence.
John: A week before your mother died. And in Palo Alto... before Jessica. And these signs, they're starting again.
Sam: Last time I saw you you fell out of a window.
Meg: Yeah, no thanks to you. That really hurt my feelings by the way.
Sam: Just your feelings? That was a seven-story drop.
Meg: You hear that? That's the sound of your friend dying. Now let's try this again. We know you have the gun John, word travels fast. So as far as we're concerned you just declared war. And this is what war looks like. It has casualties.
John: I'm gonna kill you, you know that?
Meg: Oh John please, mind your blood pressure. So this is the thing. We're going to keep doing what we're doing. And your friends, anyone who has ever helped you, gave you shelter, anyone you ever loved. They'll all die unless you give us that gun.
Dean: Promise me something.
John: What's that.
Dean: This thing goes south just... get the hell out. Don't get yourself killed all right, you're no good to us dead.
John: Same goes for you... All right listen to me. They made the bullets special for this Colt. There's only four of them left. Without them this gun is useless. You make every shot count.
Sam: Yes sir.
John: Been waiting a long time for this fight. Now it's here I'm not gonna be in it. It's up to you boys now. It's your fight, you finish this. You finish what I started. Understand?
Sam: Maybe we could tell em it was a gas leak. Might get em out of the house for a few hours.
Dean: Yeah and how many times has that actually worked for us?
Sam: Yeah. We could always tell 'em the truth.
Sam and Dean: Nah!
Meg: You're dead John. Your boys are dead.
John: I've never used the gun. How could I know it wouldn't work?
Meg: I'm so not in the mood for this. I've just been shot
John: Well then I guess you're lucky the gun wasn't real.
Meg: That's funny John. We're going to strip the skin from your bones, but that was funny.
Dean: I mean it. If hunting this demon means getting yourself killed then I hope we never find the damn thing.
Sam: That thing killed Jess. That thing killed mom.
Dean: You said yourself once, that no matter what we do, they're gone, and they're never coming back.
Sam: Don't you say that, not you! Not after all this don't you say that.
Dean: Sam look. The three of us... that's all we have...and it's all I have. Sometimes I feel like I'm barely holding it together man... and without you or Dad....
Meg: You boys really screwed up this time.
Dean: Where is he?
Meg: You're never going to see your father again.
Trivia & References
John stays in the Sleep Easy Motel. This may be considered a reference to The Simpsons' episode "The Cartridge Family." In this episode, Marge and the children stay at the Sleep Eazy Motel, but the neon sign flickers, appearing to read Sle__ _azy Motel.
The sign for Salvation quotes a bible verse: JW 2:27 "Are you ready for Judgement day?" This book and verse do not actually exist and are likely meant for John Winchester.
Radio Announcer: This is your host Jack Killian on KJCM 98.3 FM, and good night, America, wherever you are.
When Sam and Dean are waiting in the car before the Demon attacks baby Rose, this can be heard on the radio. KJCM was a fictional radio station used in the TV Show Midnight Caller about a radio host called Jack Killian whose sign-off was always "Good Night, America, wherever you are."
John blesses the water in the tank to make it holy water. According to Catholic doctrine, only an ordained priest can do this.
Erin Karpluk, who played Monica Holt, also played Robin in 9.07 Bad Boys.
Serinda Swan, who played Hospital Receptionist, also played Veritas in 6.06 You Can't Handle the Truth.
Kansas' "Carry on Wayward Son" reappears in later seasons at the start of the last episode of each season. Here, it's the second to last instead.
Screencap from "Salvation."
In John's motel room, among various maps and notes:
Handwritten note:
TEMPERATURE -
DIFFERENCES RANGE
BY SEVERAL DEGREES
DEMON ALTERS TEMP
AS IT ENTERS AN
AREA. SOMEHOW IT
MANFIESTS IT SELF
AS COLD SPOTS OR<
A map of the U.S., with X's marked in Southwest Pennsylvania, northern North Carolina, and eastern Tennessee, circled, arrow pointing northwest.
Sleep (^un) Easy Motel notepad
With doodle of figure, dark head and shoulders, halo, holding circular object.
Doodle in a rough gun shape
"Sam," in a box, circled.
Small rectangular paper with drawing of window, with fire coming out, and a dark silhouette
(...) ABOUT THAT
THAT NIGHT IN
NIGHT MARY DIED
DEMON MOST
IT DID TO MY
(...) FEELINGS
TO KEEP MAJOR (...)
BROTHER. WE MUST
FOR THE SAKE OF
CAN'T FALL APART
Newspaper article. headline: USA WEATHER REPO..
STORM OVER MID W..
in the text of the article, "rapidly into a powerful cyclone," has been marked with a box.
(picture of tropical storm)
DISTURBANCES
OF MANIFESTATION
Butler - Igloo Killinek
Air Force One Is Haunted
Danielle Steel - Secrets (HAH HAH)
Sticky note on typewritten paper : SULPHER TRACE (sic)
Road map of the U.S., with map, two hand drawn X's shown: one in California near Palo Alto, one in Arizona.
The sign for Salvation misspells Lotto as "Loto." The jackpot is $1.7 million.
According to John, Salvation has two hospitals and one Health Center. John goes to Salvation Women's & Children's Hospital and Sam goes to Salvation Iowa Medical Center.
At Salvation Hospital when John is rummaging through his false IDs one that appears is for the Oklahoma City, OK, morgue.
When Dean talks to the clerk in the health care facility, there is a poster behind her that reads: "Today is the first day of the rest of your life."
When Sam slams Dean against the wall, it mirrors the scene in the 1.01 Pilot where Dean slams Sam against the bridge when he questions the family mission.
The location of the warehouse where John is supposed to meet Meg, Wabash and Lake, is used several times in The Matrix trilogy.
Prop Goof: At the hospital, Sam is supposed to be making a list of all babies who will be six months old that week, but the birth certificate in front of him has a date of May 2nd, 1998. Also of note: The birth certificate is signed by "Robert Leader, Res." Robert Leader is one of the set designers in the art department on the show.
Prop Goof: When Dean talks to the clerk in the healthcare facility, the calendar behind her indicates the day is the Monday the 20th. The only months that occurred the 20th fell on a Monday in 2006 were February, March and November. Since we know 1.17 Hell House occurred in early June and 2.01 In My Time of Dying ends on July 19th, none of those months are feasible.
Prop Goof: There is a calendar on the wall in the hotel room John and the boys stay in; the month is unclear but it starts on a Wednesday and ends on a Friday with 31 days. The only month with that occurrence in 2006 was March.
Sides, Scripts & Transcripts
1.21 Salvation (transcript)
Episode Promo: 1.21 Salvation
Episode Promo: Last Episodes of the Season 1.20-1.22 Devil's Trap
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