Motorcycle shipment to Owensboro, Kentucky can be done easily with the right professionals to help you out. Owensboro is a city with many activities and it is the 4th largest by population throughout the state. For a motorcyclist, there is a lot to be desired and many scenic routes to take.
Just southwest of Louisville, Owensboro isn't the only place to be explored while cruising around on a bike. Shipping your motorcycle there is definitely worth the effort. Not to mention, there are plenty of reliable shipping companies to contact within the area. The safety of your bike being shipped to Owensboro is more likely than riding it there yourself.
Depending on what company you choose to have ship your bike, there are many methods of transport one will have to choose from. Select carefully and make sure that you feel comfortable with the method chosen to transport the bike. Also, take advantage of insurance during the transport if the company offers it to you.
Open air shipping is an inexpensive method that ships the motorcycle on an open flatbed trailer. While this method can be very reliable, it is also leaving the motorcycle at mercy of poor weather and road conditions.
Enclosed shipping is a safe method where the bike is placed in an enclosed trailer for its transport.
Crated shipping allows the motorcycle to be strapped to a pallet and placed within a container. It is a very dependable method, but requires a bit more preparation.
The term terminal to terminal consists of dropping the motorcycle off at a shipping terminal and retrieving it from another terminal closer to Owensboro.
Door to door is a service where the company comes to the bike's location to pick it up and then drops it off anywhere in Owensboro that you need it.
Some Transport Companies in Owensboro to Consider.


text:
Максим Л. Сретеновић је био угледни трговац и штампар, као и председник општине Горњи Милановац.

О његовом животу нема превише података, али је познато да је отворио прву штампарију у Горњем Милановцу још 1890. године. У њој су се штампале и прве горњомилановачке новине, под називом Таково.

Пре првог светског рата је био и народни посланик, а залагао се за поновно отварање гимназије у Горњем Милановцу, до чега је дошло 1912. године.

Сретеновићу је у току првог светског рата одузета сва имовина, а у току истог рата је и умро, 1916. године, од упале плућа.

Извори

Умрли 1916.
 Горњомилановчани
Стари српски штампари
Српски трговци

redpajama_set_name: RedPajamaWikipedia


Small split on spine, although binding remains solid; front endpaper missing; otherwise good. Size: Octavo (standard book size). Text body is clean, and free from previous owner annotation, underlining and highlighting. Binding is tight, covers and spine fully intact. All edges clean, neat and free of foxing. Quantity Available: 1. Shipped Weight: Under 1 kilogram. Category: Antiquarian & Rare; Britain/UK; 19th century; History. Pictures of this item not already displayed here available upon request. Inventory No: 5757.


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Perfect for roleplaying activities, the Learning Resources Design and Drill Take Along Tool Kit is a portable, compact version of the original activity centre.


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text:
Tandy 1000 Series
Tandy broke into the PC-compatible market in 1984 with their entry-level model 1000, having had great successes in the early home computer market with their TRS-80 and Color Computer range. This new offering was a clone of IBM's PC Jr (an attempt to break into the home computer market themselves). The PC Jr. was a PC with some enhancements but also with incompatibilities that would ultimately be its downfall. Before this however, Tandy saw the great potential in a low-cost PC aimed at the home market, and the 1000 was their answer to that. It was sold through Tandys own experienced network of Radio Shack stores, which were already well accustomed to selling the company's computers and its associated software.
The 1000 ran an Intel 8088 and 4.77 MHz or 7.19 MHz in turbo mode, and was fitted as standard with a single 5.25" 360 KB floppy drive. A second floppy drive could be purchased from Radio Shack and installed in a second drive bay. It had 128 KB of memory which could be expanded to 640 KB via ISA memory expansion cards. Like the PC Jr, the Tandy 1000 supported an enhanced version of CGA graphics that provided 16 colours on-screen (compared to standard CGA's 4), and 3-voice sound.
One improvement the Tandy design had over the IBM PCs was tight integration of common interfaces on the motherboard. This included a floppy disk controller, video controller, audio controller, and serial and parallel ports - these had become standard fare for all PCs at the time. All of this meant that out of the box the computer had all expansion slots free for the customer. On an IBM PC at the time, these above would have taken up 3 or 4 slots.
Tandy bundled MS-DOS 2.1 and DeskMate software with their 1000, and this software would see numerous refreshes and enhancements over the life of the 1000 series as an easy-to-use graphical user interface.
In late 1986, Tandy released the 1000EX for use in the home or in schools. Priced at $799, it ran an Intel 8088 CPU at 7.16 MHz, but could step down to run at the IBM PC original speed of 4.77 MHz. It came as standard with 256 KB of RAM (expandable to 640 KB) and a single 5.25" 360 KB floppy disk drive. Unlike the Tandy 1000 that came before it, the EX had an integrated keyboard and system unit in one. Due to its form factor, the 1000EX could not take standard ISA expansion cards - instead it accepted Tandy "PLUS" expansion boards.
It was shipped with a special version of DeskMate, called Personal DeskMate. This incorporated a word processor, spreadsheet, electronic filer, paint, calendar, and communication applications, as well as desktop accessories like a calculator, notepad and phone directory. Also bundled was MS-DOS 2.11 with GW-BASIC.
The 1000SX was essentially the same as the Tandy 1000EX, but in the standard PC mould with a separate system unit and keyboard (like the original 1000). Finally here was a machine with five 8-bit ISA slots for expansion, could support an EGA or VGA card, hard disk controller, and a math coprocessor. It was still running an Intel 8088 at 7.19 MHz and came with just 384 KB of RAM (easily expandable to 640 KB with standard DRAM chips), but also got a DMA controller. With the SX, Tandy had really distanced itself from the PC Jr. issues and entered the "real" PC compatible world. It was bundled with MS-DOS 3.2 which added 720 KB floppy disk support.
In 1987 Tandy expanded their 1000-range with the launched of the 1000HX. This was designed as the successor to the 1000EX, with a similar integrated keyboard and system unit. It came with a 3.5" 720 KB floppy drive, 256 KB of RAM, and had DOS 2.11 in ROM for fast boot-up. As with the 1000EX, this meant the HX didn't support standard ISA slots, instead requiring "PLUS" cards for expansion.
It was bundled with DeskMate II on floppy disk.
1000RL
In July 1991 Tandy launched the 1000RL, which comprised a floppy disk-only model or one with a floppy drive and hard disk. Just as with all the 1000-series, this was an XT-class computer, running an Intel 8086 microprocessor at 9.54 MHz, and 512 KB RAM. The RL was designed for home use, and so it came with a new version of DeskMate called DeskMate Home Organizer. This had 15 new applications divided into 3 categories: Personal, Kitchen, and Financial. The Home Organizer version also got 9 other applications which were Desktop, Text, Draw, PC-Link, Telecon, Hangman, Music, Sound, and Address Book. With the 1000RL Tandy finally standardised the mouse port (now PS/2) and the parallel port (now Centronics), just like the 2000, 3000 and 4000 computers.
The 1000RL came in two configurations: the 25-1450 was a single floppy drive while the 25-1451 got a floppy drive and 20 MB hard disk. This also came with the "SmartWatch" realtime clock built-into the motherboard. The 25-1451 model had MS-DOS and DeskMate pre-installed on the hard disk.
The series comprised the following models:
Tandy 1000 (model 25-1000): Intel 8088 , single 5.25" floppy drive
Tandy 1000A: a 'refresh' of the 1000 with a co-processor socket, and bug fixes.
Tandy 1000EX (model 25-1050): Intel 8088 7.16 MHz, single 5.25" 360 KB floppy drive - $799
Tandy 1000HX (model 25:1043): Intel 8088 7.16 MHz, single 3.5" 720 KB floppy drive - $
Tandy 1000SX (model 25-1051): Intel 8088 7.16 MHz, 384 KB RAM, two 5.25" 360 KB floppy drive - $1,199.00
Tandy 1000TX (model ?): Intel 80286
Tandy 1000SL
Tandy 1000RL (model 25-1450): Floppy only, no monitor - $599.95
Tandy 1000RL (model 25-1450): Floppy only, monochrome monitor - $749.90
Tandy 1000RL (model 25-1450): Floppy only, colour monitor - $899.90
Tandy 1000RL (model 25-1451): Floppy drive and Hard disk, no monitor - $999.95
Tandy 1000TL (model ?): Intel 80286
A number of optional accessories or upgrades were available for the 1000-series:
For 1000EX:
25-1014: PLUS RS-232C Option Card - $79.95
25-1015: PLUS Digi-Mouse Controller/Calendar - $99.95
25-1017: PLUS 300 baud PC Modem - $99.95
25-1018: PLUS 1200 baud PC Modem - $199.95
25-1019: PLUS Network 4 Interface - $299.95
25-1020: VM-4 Monochrome Monitor - $129.95
25-1022: CM-10 RGBI Colour Monitor - $459.95
25-1023: CM-5 RGBI Colour Monitor - $299.95
25-1062: Memory Plus Expansion Adapter - $129.95
For 1000HX:
25-1060: External 5.25" 360 KB Floppy Drive - $
For 1000RL:
25-1033: SmartWatch socket (for adding a realtime clock) - $39.95
25-1042: PS/2-style mouse - $49.95
25-1047: 20 MB SmartDrive - $
25-1075: 3.5" floppy disk drive- $
25-1082: 256 KB RAM expansion - $59.95
25-????: 2400bps modem - $
Hardware - BIOS
The Tandy 1000 used a Phoenix BIOS. The original version 01.00.00 is known to cause data corruption with some types of hard drive controllers. This was fixed in version 01.01.00 along with a few other bugs. The BIOS is held in two chips, both of which are 32 KB in size. If you need to replace these two chips, you can use two 28C256 chips.
Hardware - Drives
The Tandy 1000 came with IBM-standard floppy disk controller embedded on the motherboard, and which supported two drives. There was no direct support for hard disks with this model as they were very expensive, and the 1000 was designed as an entry-level model.
The 1000RL got a hard disk option called the "SmartDrive", which was a 20 MB affair. If purchased later for a non-HD 1000RL, the hard disk came with initialization software that ran in DeskMate.
The 1000EX had an expansion port on the back that supported connection of an external floppy drive (either 5.25" 360 KB or 3.5" 720 KB).
Tandy floppy disk drives require a ribbon cable without a twist! They also require setting jumpers or switches on the drives to tell the machine which is drive A and which is drive B. On an IBM PC, both drives are set to DS1, and the twist turns the drive at the end of the cable to DS0. If you are using a modern 1.44MB drive in these systems, they are generally soldered to DS1, so they will be the B drive. 5.25" drives should always allow you to set DS0 or DS1. But one of the great things about a Tandy is that they allow you to boot from the B drive by pressing the F3 key at startup. If you have a standard "universal" floppy cable (with 3x pin connectors and 2x card connectors), you have to untwist the cable by prying off the end connectors, flipping the wires around, then snapping the connectors back on again. Tandy did not support high density drives until the RLX and TL/3, but you can use most 1.44MB floppy drives with double density/720KB media.
All early Tandy 1000s (1000, 1000A, and 1000EX) with a hard disk used IRQ 2 for the hard disk and IRQ 5 for video. On an IBM PC and compatible these were the other way around. This could lead to issues if you were trying to fit a third-party hard disk whose controller insisted on using IRQ 5, or a video card that only worked on IRQ 2! The 1000SX (and beyond) fixed this.
For modern Tandy "retro" users, do bear in mind that Tandy MS-DOS 3.0 through to 3.3 only supports hard disk partitions of 32 MB each. DOS 3.3 added support for extended partitions
Hardware - KEYBOARD
The Tandy 1000 uses a proprietary keyboard port with an 8-pin DIN along with two joystick ports (6-pin DIN). All of these are compatible with Tandy's earlier TRS-80 home computers, and hence are not compatible with IBM hardware. These ports are all situated on the front of the system unit. The keyboard is also a little different to most PCs. There is no SCROLL LOCK key - instead you use the combination of CTRL-BREAK.
The keyboad on the 1000EX has 90 keys.
Hardware - Video
On models that pre-date the SL/TL/RL models, these came with IBM PC Jr graphics. This is both BIOS- and memory-compatible with CGA, though not register-compatible. This graphics standard is sometimes referred to a TCGA, TGA, Tandy CGA, or Tandy Video I. This basically adds several resolutions onto the standard CGA ones. They are:-
Most CGA programs that go through the BIOS to interface with the video adapter will work.
Because PC Jr/Tandy graphics aren't register-compatible with EGA, the Tandy cannot 'emulate' EGA. The same is true of the lower-res EGA resolution of 320 x 200 x 16 - the Tandy might be able to handle that resolution at that colour depth, but the register mappings mean it's not true EGA, so EGA programs won't work.
When Tandy introduced the RL, SL and TL models, they upgraded the video adapter to what is sometimes called ETGA or Tandy Video II. This takes either a digital CGA or mono TTL monitor, and pressing Ctrl-Alt-Shift-V reboots the system and switches monitor types. The setting is stored on an EPROM so that further reboots will assume the same monitor is still connected. When a mono TTL monitor is used, the video is compatible with Hercules. When a CGA monitor is used, the video is fully compatible with CGA and PC Jr. Tandy Video II has all the graphics modes of Tandy Video I, but adds 640 x 200 x 16. The BIOS does not support this mode, but programs that directly talk to the video circuitry via its registers will work.
The following titles are known to have supported this special Tandy video mode:
Deskmate 3
Math Rabbit Deluxe
Sargon V
Time Riders in American History
Treasure MathStorm
The Tandy 1000 has both a 9-pin DSUB (marked "RGBI") for connection to a colour monitor, a second 9-pin DSUB (marked "VIDEO") for connection to a monochrome monitor, and a couples of 'phone' connections (marked "V/A") for wiring up to a television via an RF modulator. It has a second RCA socket which is the audio line-out.
The Tandy 1000 reserves 16 KB of RAM for video memory. This is the same as the IBM PC Jr. It is worth mentioning that the PC Jr did not need a DMA (Direct Memory Access) controller - this is because the 128 KB of RAM was shared between system and video, so the RAM was continually being refreshed by the video controller. When Tandy made it's "PC Jr clone" (the 1000), they did the same thing - omitted a DMA controller. The same was true of the 1000A, 1000EX, and 1000HX. The was noticeable in certain circumstances, such as when the CPU was accessing the disk drive it would "ignore" keystrokes.
The Tandy 1000 can switch between 80-column text mode and 40-column text mode by simply pressing the F12 key. The default 80-column text mode on the Tandy annoyingly uses 225 lines. IBM uses a 200 line text mode. All graphics modes in these machines use 200 lines. In order to get a proper aspect ratio with the graphics modes, the monitor's vertical size control has to be set almost to the point where the graphics are almost hidden by the monitor bezel. When you return to the text mode, this winds up cutting off either the top, bottom or both lines of the display. Use Tandy MS-DOS 3.2 mode.com command: mode 200, to fix this. This does not work in the TL machines.
Like the Tandy 1000, the 1000EX got a composite video out socket on the back as well as an RGBI port for connection to a colour monitor.
Hardware - MONITORS
Several monitors were made available for use with the Tandy 1000 series. The CM-5 was a CGA colour monitor that supported all the Tandy 1000-series resolutions. The CM-4 was an older version of the CM-5.
The CM-11 is also a CGA monitor, but has a much higher dot pitch than the CM-5, which makes the image much clearer. Both the CM-2 and CM-10 are older versions of the CM-11.
The VM-1 is a monochrome monitor that was designed for the Tandy 2000.
The VM-2 and VM-4 are both monochrome composite monitors, designed to be used with the composite CGA port on the 1000, 1000HX, 1000EX, 1000SX and 1000TX.
The VM-3 and VM-5 are also monochrome monitors, but are digital TTL (MDA/Hercules-compatible). These can be used with a 1000SL, 1000TL or 1000RL only.
EGMs are EGA monitors, and VGMs are VGA monitors.
Hardware - PORTS
The original Tandy 1000 came with a lot of ports, but many were only compatible with Tandy's own TRS-80, not IBM PC-standard. This included the two joystick ports as well as the mouse port.
The parallel interface was a proprietary edge connector at the back of the T-1000 system unit, instead of the more common Centronics 25-pin DSUB connector seen on IBM PCs and other compatibles.
The T-1000 also came with a light pen port.
The Tandy 1000RL came with a single 10" 8-bit ISA expansion slot.
The Tandy 1000EX, being an integrated unit like many home computers couldn't take any standard ISA cards. Instead it had capacity for a single "PLUS" expansion board or two PLUS expansion boards when used with the Memory PLUS Expansion Adapter. These "PLUS" expansion cards used the same interface as the 8-bit ISA standard, and eventually Radio Shack would sell adapters in their stores that allowed PLUS cards to be inserted into a standard 8-bit ISA slot.
The Tandy 1000SX had five 10" 8-bit ISA expansion slots.
The Tandy 1000 can be expanded to the full 640 KB by installing a memory expansion card into one of the free 8-bit ISA expansion slots. The card from Tandy (and some other authorised peripheral companies) actually comes with a DMA controller for faster (direct) access to it.
For the 1000EX and 1000HX, these too require an expansion card to increase memory capacity, but these must be "PLUS" expansion cards, since these computers don't have standard ISA slots.
All other systems can take standard DRAM chips directly on the motherboard. You can use faster chips than are required. The SX will take eight 256k x 1 150ns chips. You will also need to remove jumper E1-E2.
The TX uses four 64k x 4 120ns DRAM chips. The chips go in the sockets labelled U54-57. Remove the jumper labelled E9-E10.
The TL uses four 64k x 4 120ns DRAMs. The chips go in the sockets labelled U36-39. There is no jumper to move.
The TL/2 uses four 64k x 4 120ns DRAMs. The chips go in the sockets next to the other RAM chips, in front of the expansion slots. There is no jumper.
The TL/3 uses four 64k x 4 100ns DRAMs. The chips go in the sockets labelled U4-7. There is no jumper.
The SL uses eight 64k x 4 120ns DRAMs. They go in the sockets next to the other chips. There is no jumper. The SL/2 uses 4 64k x 4 120ns DRAMs. They go next to the other chips. There is no jumper.
The RL and RL-HD use two 256k x 4 100ns DRAMs. They go in the sockets labelled U19 and U23. There is no jumper.
The RLX uses four 256k x 4 100ns "ZIP" DRAMs. This not a common type of chip. They go in the sockets labelled U23-26. There is no jumper.
The RLX-B uses four 256k x 4 100ns "ZIP" DRAMs. They go in the sockets labelled U2, U4, U5, and U9. There is no jumper.
The RLX-HD, RLX-HD-B and RSX's came from the factory fully populated with conventional RAM.
ZIP DRAMs for the RLX are hard to find. You are looking for Samsung chip #KM44C256AZ-8.
When you install additional conventional memory in your system, whatever video memory was being "stolen" by DOS goes back to the video, if DOS has 640 KB. The amount of DOS RAM you gain by the upgrade thus may not be equal to the amount of RAM you install, since whatever was stolen before is lost. There is no way to make the Tandy BIOS allocate more than 640 KB for DOS, and no way to do it by programming either.
On the original 1000, 1000A, and 1000HD, you cannot upgrade the video to VGA. On these systems, the BIOS will not scan for a video ROM or disable the onboard video. This is deliberate. Upon startup, one of the first things the BIOS does is scan for ROMs on your expansion cards. On VGA cards, their ROMs are usually stored at address C000:0000. Hard disk controllers usually have their ROMs at address C800:0000. So because the Tandy is programmed to ignore EGA or VGA cards it starts its scan at address C800:0000, allowing it to pick up other cards, but not video cards.
The EX and HX can have VGA but will need a special "PLUS" card because of their nonstandard expansion slots. The SX and TX need to have DIP switch 1 turned off.
The SL's, TL's and RL's won't require any hardware changes; just plug in the card.
The RLX's and RSX's came as standard with VGA. Both can accept upgrade video cards as well.
Some programs may mis-identify your VGA card as CGA or EGA. This is because the Tandy BIOS fails to set the Video Configuration Code byte at 0040:008A. The default value of this byte is 3Fh. The correct values are:
0Bh - for a single VGA color card;
0Ch - for a dual-monitor system with VGA color and MDA mono;
0Dh - for a single VGA mono board;
0Eh - for a dual-monitor system with mono VGA and MDA.
The solution is to put a short program in your autoexec.bat file that will set this byte to the correct value upon startup. Without the fix, the VGA card will function, but some programs will misidentify it as EGA or CGA. There are various programs around to do this. Radio Shack included one with their version of the Paradise card, Get vgafix.zip.
Hard Drive Support
Math Co-Processor
1000RL - 14" (W) x 15" (D) x 2 7.8" (H)

redpajama_set_name: RedPajamaCommonCrawl


Before we got sick, our washing machine broke. We've been without a washing machine for about a month now.The boys really couldn't care less, and for those weeks we were sick we all pretty much just wore our pajamas, so we've been doing alright. But you can only do your laundry at a friend's house so many times(like, once) before it gets awkward.
Yesterday we had a fix-it friend come work on it, to no avail. So Dad made the last minute decision to take the actual machine to the big city and have it worked on there. Now, understand, we live in a hundred year old house, not made to hold washing machines. The laundry area, when it was added on sometime along with the (gasp, yes, we have indoor plumbing)bathroom, was originally under the second staircase off the kitchen. To get the machine in that space, the original owners had to cut out and then replace the wood trim of the doorway.
Now, when we bought the house we inherited that same and by now rather old washing machine which was very much stuck in that area. About seven years ago, we had a baby and decided to make things even more interesting by taking out the second stairway and make it into a pantry, since it was always covered in stuff anyway, and we bought a new washing machine as well. The old one was a good twenty years old at least, and I seem to recall it had the intermittent problem of gushing water all over the floor. So, at that point, to get it out and the new one in, not wanting to cut out the woodwork, we had the stairs tore out and had to drag it through the completely empty pantry-to-be. Today, our pantry is very much fuller, and that is still and always will be the only way to get a washing machine in or out to the only place a washing machine can ever go in our old house. This is probably more detail than you've ever wanted. Anyway, last night we had to take out three whole shelves in the pantry and completely empty the floor so the washing machine could go.
We're still waiting the verdict on the fixability of our machine. I pray we won't have the expense of buying a new machine; we've already invested a bit into having this one fixed. Meanwhile, our fancy plates and canned good sit stacked on the kitchen floor while we wander about in our unwashed clothes. Please, no visitors.
...of those who bring good news, but since we're all still sick I guess I don't really have any good news. Now I know why people die of influenza. Now I understand why the influenza outbreaks were so dreaded: I guess one plus to this is that I can now better understand that part of history. After twelve days of a fever, Mom to the clinic and they immediately hospitalized her for pneumonia. Dad is well enough to go back to work now, and the rest of us are all in various stages of coughing and weakness. This will be a three-week illness, at least.
I have long resisted wearing heels. Maybe it's because I(along with 95% of all home-schooled girls) read the Elsie Dinsmore series in my youth, where one character fell down the stairs because of her heels and was permanently crippled; but I prefer to think it is because of my own common sense and practical nature. I don't want anyone to think I am at all endorsing heels: heels are dangerous and kids, do not try this at home. You may end up permanently crippled. I pray I will not.
Anyway, I had a short time to make a decision and Goodwill had a limited selection, I rarely get to town to go shopping and these happened to be in my size, so I bought them. There was a point yesterday when a few of us had hopes to get out and go to church, so I specially prepared my feet with a chocolate-scented sugar scrub because goodness, my feet SHOW in those things! The pedicure companies and the sandal companies must be in league. We ended up being still to tired to attend church, so if it were not for this post I would have sugared feet for nothing. Feel honored I am sharing with you.
On a different note, we just watched the new "Star Trek" movie, and action scenes aside it made me laugh, which was refreshing after living like the undead for a week, but do you know how hard it is to laugh when you have a cough? It's hard. I have to admit the movie made me a bit queasy during all the spinning through space scenes- but "Up" does the same thing; I can't stand the thought of people floating in space.
This post may seem a little wordy or unusually flippant; please don't take it badly; after two weeks of confinement the (hopefully humorous)sarcasm is flowing free.
Ill: unhealthy, ailing, diseased, afflicted.
My whole family has been miserably, horribly, terribly sick all this past week. There's no point to this post other than to bemoan our situation, so don't feel like you need to read it.
Pretty much all of those apply to my family. Symptoms include splitting headaches, extreme weakness, a cough, and achy muscles. The coughing is almost constant when you get the eight of us together. Mom and Dad got it the worst: Dad actually had a headache for three days straight, and Mom was so weak that she couldn't even sit up for long. Parents aren't supposed to get sick, so I don't know what they were thinking. We certainly aren't strong enough to nurse them. We haven't been this sick for a long time. Illness certainly makes heaven look even more appealing.
Nebraska summers are humid. This year has been much wetter than normal, with frequent rain and hotter temperatures, making Nebraska seem like a mid-western corn jungle. The weather has had an interesting affect on our life here: In this weather, your hair is curly whether you want it to be or not, and even if it's naturally straight. Breathing is drinking and walking is like swimming. Everything is sticky- you sit on the couch(it's leather) and you're stuck. Your fingers stick to the keyboard. The laundry never really dries. You can drink water when you're not thirsty and never have to visit the (ahem) powder room. One more month and then we'll be done with it, and we just have to take it a day at a time.


text:
Is Medicine Still Good for Us?
A Primer for the 21st Century
By Julian Sheather
2 copies in stock
Theory & Philosophy
Over the course of human history, medicine has achieved incredible successes--but at what cost? This latest book in The Big Idea series explores the state of modern medicine, examining the ethics of medical and healthcare practices and the impact they have on modern life. This fascinating analysis engages with the debate surrounding the escalating costs, both financial and ethical, of medicine today. Intelligent and provocative, Is Medicine Still Good for Us? dissects common assumptions about medicine, helping the reader create their own informed opinion about its extraordinary achievements, limitations, injustices, and inevitable failures.
Dr. Julian Sheather, an ethics adviser to Doctors Without Borders, contextualizes medicine as a science, art, institution, and ideology, outlining the pros and cons of what medicine has become in the signature Big Idea textual approach. Accompanying Sheather's text are numerous informative illustrations that deepen the reader's understanding of the material.
A timely addition to the series, this book will engage those who love to debate, who are interested in ethics and philosophy, and those working in the medical field.
Thames & Hudson (4/16/19)
What Shape Is Space?: Primers for the 21st Century
By Giles Sparrow
Is Democracy Failing?: Primers for the 21st Century
By Niheer Dasandi
Is Gender Fluid?: Primers for the 21st Century
By Sally Hines
Will AI Replace Us?: A Primer for the 21st Century
By Shelly Fan


51 motivational, inspiring, down to earth and in your face fitness tips – that flat out WORK!
Once you go "0 Excuses" – you'll never, EVER go back!
It is with great pleasure – – and GUSTO – and vim and vigor (and of course, after a superlative workout out there) that I bring to you the SECOND Volume of "Fitness Central".
After the rousing reception the first compilation received (and rightfully so – those are evergreen tips that are worth their weight in SPADES – or GOLD, if I might say so) – I received a lot of questions about when I was going to come out with Volume #2.
I vacillated for a while on it, being I had plenty of other things on the table – but I've got it done NOW – here it is!
If you're not sure what Fitness Central – Volume #2 entails – and the "nitty gritties" behind the book – well – the sales page for the FIRST Volume on this site explains it all.
Go on ahead, and grab that little monster first – and THEN come back and grab THIS one.
And after that – be on the outlook for Volume #3. It's coming – I promise you THAT!
A 0 Excuses Fitness fan. If so, you'll love these tips so much you'll want to put the paperback copy of this book right next to your bedstand – – or office desk – – or even your car to glance at throughout the day!
Interested in building brute, animal like functional strength and a body every bit as strong as it looks.
Looking to improve your stamina and conditioning levels beyond belief.
Getting tired of that "run down" feeling you experience at the end of the day – – and exercises that will help you banish this feeling forever!
Looking to improve your pushup – or pull-up – or any bodyweight exercise "numbers" – and do so in a smart and methodical manner.
Looking to banish upper back, shoulder, wrist and other "nagging" pain forever.
The average "Joe" or "Jane" looking for tips on getting into shape and lose weight without spending the house on gyms and fancy memberships.
A fitness enthusiast looking for tips that'll take you to the next level – and quickly!
A seasoned fitness pro or athlete looking for advanced tips – – or that "X" factor that'll allow you to score, and score BIG over the competition!
Motivational reads that apply not only to fitness – – but life as well, if you read between the lines.
And any other category NOT covered above. This truly is a book which has "something for everyone".
On maintaining yourself at OPTIMAL levels no matter WHAT the circumstances are – or what the environment is!
Exercises that if done right – – can quite literally SAVE YOUR life someday – – and yes, I have include PROOF of this too. You won't want to miss this!
How heavier people CAN do pull-ups – but it has to be a certain type of "heavy"! This alone is worth the entire price of admission, me think!
Why training at NIGHT can be an excellent, excellent thing indeed.
An exercise that'll rid you of shoulder pain – forever!!
As for the burning question, eh?
Well, to be frank – the SKY is the limit, my friend. Given the sheer practical value of even ONE of these tips – given how I've worked over the years to glean this knowledge from "being in the trenches" – given all the trips to China – and everything else, and all the man hours SPENT – and SWEATED while I accumulated this storehouse of knowledge – I could literally charge you upwards of $500 and be JUSTIFIED in doing so.
I wouldn't be lying to tell you that even one or two of these tips could be enough to set you on the path to life time ACHIEVEMENT fitness wise – life wise – and in many other spheres you so choose to apply the stated principles (in the tips) to!
In fact, given the cost of swanky gym membership – personal trainers who don't know their you know what's from a HOLE in the ground (more in the manual on this very point as well) – and all the injuries (recurring, I might add) you sustain in the ole gym, I'd literally be offering it to you at a steal for even $700 or so.
But guess what – I am NOT going to charge you $700 or close to it.
I won't even charge you HALF of that. In fact, I'm in such a good mood that I'm not even going ask for a quarter of $700 (which is a pittance to be honest).
All I'm asking you for is a measly $59.97, my friend. That's it – nothing more.
Less than sixty bucks – and you get your hands on a storehouse of info that you might train a lifetime to learn – and still not learn fully.
Information that has life changing potential – information that your personal trainer does NOT know about.
And certainly, and by a long darn shot, info your GYM will NOT be able to provide you with.
Without further ado then, click on over, and reserve your copy now. It'll be one of the best fitness related decisions you EVER make.


text:
Krmed is een plaats in de gemeente Bale in de Kroatische provincie Istrië. De plaats telt 69 inwoners (2001).

Plaats in Istrië


text:
AnalysisProfiles
Opponent Profile – New York Jets (A)
By Sam Moores
Head Coach – Adam Gase
Offensive Playcaller – Adam Gase
Defensive Playcaller – Gregg Williams
Offensive Captains – Sam Darnold, George Fant
Defensive Captains – Steve McLendon, Marcus Maye
Special Teams Captains – Matthias Farley
2019 Record – 7-9
Key Acquisition – George Fant
LET'S TAKE A LOOK AT THE NEW YORK JETS
Our Miami Dolphins will face the New York Jets for the second time, this time with Tua Tagovailoa at the helm, subject to a thumb injury sustained in practice. These New York Football Jets are on their way to a 0-16 season, aiming for Clemson's Trevor Lawrence. Right now Adam Gase's team are 0-10, with 5 more losses since we last faced them.
That game ended 24-0 to the Dolphins and saw Tua gain his first NFL snaps on the final drive. Since then the Jets have lost to the Bills, Chiefs, Patriots, and Chargers and are a better football team than they were six weeks ago.
At Quarterback, it's looking like Sam Darnold will return from an injured throwing shoulder and will start having been a full participant on Friday practice. To be completely honest, I don't think it really matters who starts at QB for the New York Jets though, as Flacco and Darnold have been just as bad as each other. PFF have the third-year starter 34th with a passing grade of 57.1, whilst Flacco is 36th with 55.8.
Whilst at receiver, the New York Jets actually have a lot of talent, perhaps more so than Miami. Denzel Mims has been outstanding since his debut a month ago, he's not scored a touchdown yet but is averaging 54 yards per game with Joe Flacco at Quarterback. We could do with a proper slot receiver like Jamison Crowder in the Dolphins receiver room, he's PFF's 36th graded wideout ahead of the likes of Juju Smith-Schuster and John Brown. The 6th year player has missed time this year and has still put up 425 yards and 3 TD's on the year. Breshad Perriman is a gadget deep threat that will always pose problems too.
That offensive line grades pretty well too, better than ours anyway. Mekhi Becton is the New York Jets 3rd best offensive player according to PFF, behind Jamison Crowder and Denzel Mims. In fact places, 4-8 are all lineman with Becton, Alex Lewis, and Greg Van Roten all grading in the top half of all eligible lineman.
The running back position isn't that great which will help Miami tenfold, the two biggest weaknesses with this Dolphins team are running the ball and stopping the run, so the fact that Lamical Perine is now on IR and that an ancient Frank Gore is the lead back will massively help them.
Other than that the Offense is a whole load of bad. Defensively however, they're a little better. Marcus Maye is really really good and has learned from Gregg Williams massively, just as did Damarious Randall in his Cleveland team. He picked off Fitz last game. PFF has him as their third-ranked safety ahead of the likes of Budda Baker and Minkah. Whoever plays between Tua and Ryan Fitzpatrick will have to look out for him. The New York Jets have a pretty good corner too in Brian Poole, he's got two picks on the year and is excellent off the corner blitz.
The Jets d-line is also pretty good, and ranks highly with PFF. Not one of them has played more than 400 snaps proving that rotation is key. Something Tua may struggle with should he play. Quinnen Williams has piped up since those trade rumours at the deadline whilst fellow interior players Folorunso Fatukasi and Henry Anderson are in the top 50% of IDL.
Linebackers aren't that great, awful in fact. When ex-Dolphin Neville Hewitt starts for you, you know you've got a problem. Avery Williamson was traded away on deadline day, leaving Harvey Langi with more snaps. He's been awful for the New York Jets though, with a measly 42.4 total defense grade. Something for Chan Gailey to target.
That's it for the New York Jets Opponent Profile, it won't be an easy win whatsoever. If we can start fast and get out in front I'm certain the Dolphins will beat the New York Jets, if not, it could be a long day.
For more like this, you can visit our news section. Also, follow us on Facebook and Twitter for news, views, competitions, and much more.


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"Puss in Boots" Sequel Exceeds Expectations
Zoe Karoub, Contributing Writer
"Puss in Boots: The Last Wish" enamored nostalgic teens and adults for its entire runtime. Critics similarly enjoyed the film, as it opened to rave reviews.
"Babylon" Doesn't Quite Hit it Out of the Park
Landis Hall, Contributing Writer
Though it is engrossing, "Babylon" is messy in the ways it tries to be epic. However, Chazelle's attempt is deserving of a watch, if only for the booming score and Margot Robbie's fiery performance.
Making Mac and Cheese with Ease
Kari White, Culture Editor
A classic mac'n'cheese is the first recipe in the College Cuisine column. The column aims to give fellow students simple, cheap meal ideas.
Celebrating the Year of the Rabbit at the Met's Festival
Allison Schneider, Contributing Writer
The Metropolitan Museum of Art held a series of cultural events in celebration of the Lunar New Year. The activities ranged from musical performances to art demonstrations to pop-up shop promotions. The Met exhibition is open until Feb. 4.
Dive into Sir Terry Pratchett's Discworld
Michael Sluck, Production Editor
The 41-book series is not bound by a limiting genre; it is fantastical, comedic and genuinely smart. Many Discworld books can be found in major bookstores and Fordham's Walsh Library.
Getting Back Into School Rituals
Stella McFarland, Contributing Writer
In preparation for the spring semester, which can be stressful and difficult for some, students contemplate ways they can reconnect with themselves and form habits that will benefit them in the coming months.
"The Last of Us" is a Promising Adaptation in a Series of Hit-or-Misses
Juliet McAlee, Contributing Writer
"The Last of Us" proves to be one of the best video game to television adaptations with great performances and incredible world-building. The show's first and second episodes are exciting fans for what is to come in the rest of the series.
Junior Sings Herself into the Satin Dolls
Isabel Danzis, Editor in Chief
Ryan's experience in the Satin Dolls is congruent with her experience at Fordham; her time with the Satin Dolls have taught her to be independent, though she notes how her abilities within a team have improved, too.
"M3GAN": TikTok Dance Turned Box Office Success
Tony Cuellar, Contributing Writer
The long awaited and much-joked-about "M3GAN" opened to impressive box office earnings and a TikTok dance trend. The horror flick surrounds a child's robot companion who turns out to be evil.
Gracie Abrams Asks Us All "Where Do We Go Now?"
Amélie Acevedo, Contributing Writer
Gracie Abrams' lead single in support of her upcoming debut album, "Good Riddance," depicts heartache that feels universal among listeners who tune in in order to feel like they are not alone.
"Flowers" by Miley Cyrus Reveals Why Liam Hemsworth Couldn't Be the One
Cyrus returns from her rock stunt to the familiar pop sound she became widely known for. In her video for "Flowers," Cyrus dances without a hint of regret concerning her ex-husband Liam Hemsworth.
"Avatar" Sequel Brings CGI To A Whole New Level
An unbelievably long runtime and questionable dialogue prevented "Avatar: The Way of Water" from being perfect, but its impressive visual effects and James Cameron's direction left audiences excited for the rest of the sequels.
New Releases to Keep Your Letterboxd Alive in '23
Letterboxd watchlists are sure to be packed with the plentitude of intriguing movies slated for 2023. Film fans are especially excited for new releases from auteurs such as Wes Anderson and Ari Aster.
Celebrities Go Bold at the Golden Globes
The attendees of the Golden Globes stunned in dresses from notable designers like Christian Siriano, Gucci and Louis Vuitton. A possible awards season fashion trend emerged with many actresses sporting gothic seeming tulle-heavy, black dresses.
The Golden Globes' Attempted Comeback
The 80th Golden Globes aired live on NBC after the 2022 ceremony was not broadcasted as a result of a scandal within the voting body. Many celebrities attended the event, confirming the wrongdoings will not have a long-term effect on the future of the awards show and its reputation in the industry.
Diving Deeper into SZA's Hit Album: "SOS"
SZA's first album in five years, "SOS," explores a wide range of feelings. Her emotional resonance has already acquired the star a Billboard Hot 100 #2 hit with her song "Kill Bill" and droves of new fans as listeners fall in love with her music all over again.
Smushie is a Smash Hit at Rodrigue's Coffee House
With engaging sets from Chicago-born indie band Smushie and Fordham student band Crotana, this free Rod's concert was a breath of fresh air.
Our Story Provides a Safe Space for Students to Share
Sentiments of gratitude, hope, and pride make up the most magical aspects of Our Story.
Rose Hill Symphony Orchestra Shines in Fall Concert
Just before Thanksgiving Break, the Rose Hill Symphony Orchestra put on their fall concert to showcase the musical talents of Fordham students.
Yo La Tengo's "Fallout" and the Undulating Emotions of Time
Cathartic and droning, Yo La Tengo's latest single, "Fallout," bears familiar thematic fruits of their long-developed discography.
"MM…FOOD" and the Unique Sound of MF DOOM
"MM...FOOD" is both an anagram of MF DOOM's name and the perfect introductory album to the artist's clever and catchy discography.
SZA's "Shirt" Ushers Us Into a New Era of Sustainability
After a year and a half of teasing her fans, SZA finally released her newest single, "Shirt."
Maybe it's a "Bad Idea," but it's a Great Song
Dove Cameron's single, "Bad Idea," is a great addition to her discography with well-written lyrics and catchy rhythm.
Every Woman Shouldn't Have To Be An Anti-Hero
Nicole Braun, Opinion Editor
"Lost in Translation:" A Silence Worth 1000 Words
Frances Schnepff, Social Media Director


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Q: trouble finding wordpress home page I am having trouble trying to find the homepage for a wordpress site. I am not the original developer on this page. I have looked and looked for the page in pages, portfolio, posts, etc. The settings in reading is set to the default blog, when I go to appearance->customize->Static front page, It is set to latest posts. I was told by another employee that the previous developer was editing a file so I am wondering where this Blog file would be at? Also I am running the striking theme and inside the admin panel for the Blog section it said the page is set for news, however when I go to the news page it is completely empty. Does anyone have any ideas? I am not a big wordpress guy!

A: If you know the name of the theme being used(striking?) you should be able to find all custom files in
wp-content/themes/striking/

I'd check home.php or index.php
Hopefully that gives you a decent starting point.

A: A starting point is to look in Settings > Reading and check Front page displays.
What does it say?
Also have you read http://codex.wordpress.org/Creating_a_Static_Front_Page ? May be useful.

A: The striking theme homepage is created by going to the admin->Striking->Homepage->Homepage Content

redpajama_set_name: RedPajamaStackExchange


This graph depicts the value of the Minnesota Timberwolves franchise of the National Basketball Association from 2003 to 2019. In 2019, the franchise had an estimated value of 1.26 billion U.S. dollars.
* Value of team is based on current stadium deal (unless new stadium is pending) without deduction for debt (other than stadium debt).
Florida: Do you have a favorable or unfavorable opinion of Ted Cruz?


text:
Q: Select row in tableview programmatically when row is not visible I have to select one by one cell in a tableview and "execute" this row to show their detailviewcontroller. I use the following code. Everything is working as it should be, as long as the next row to be executed is visible in the screen. Is the next cell in the red zone the user has to manually scroll to this cell and than it get's executed.
Any help
- (void)showNextExercise:(NSNumber *)nextOne{
int nextRow = [(NSNumber *)nextOne intValue];
NSLog(@"Next Row: %i", nextRow);

//Auto Start next Exercise //
NSIndexPath *indexPath = [NSIndexPath indexPathForRow:nextRow inSection:0];

if ([self.tableView.delegate respondsToSelector:@selector(tableView:willSelectRowAtIndexPath:)]) {
    [self.tableView.delegate tableView:self.tableView willSelectRowAtIndexPath:indexPath];
}

//[self.tableView selectRowAtIndexPath:indexPath animated:YES scrollPosition: UITableViewScrollPositionNone];

[self.tableView selectRowAtIndexPath:indexPath animated:NO scrollPosition:UITableViewScrollPositionNone];

if ([self.tableView.delegate respondsToSelector:@selector(tableView:didSelectRowAtIndexPath:)]) {
    [self.tableView.delegate tableView:self.tableView didSelectRowAtIndexPath:indexPath];
}

[self performSelector:@selector(performSelectorWithDelay) withObject:nil afterDelay:0.2];

//END Auto Start next Exercise //
}

-(void)performSelectorWithDelay{
    [self performSegueWithIdentifier:@"showDetail" sender:nil];
}
- (void)tableView:(UITableView *)tableView didSelectRowAtIndexPath:(NSIndexPath *)indexPath
{

    NSManagedObject *object = [[self fetchedResultsController] objectAtIndexPath:indexPath];

    if (![executedExercises containsObject:[NSString stringWithFormat:@"%@", [[object valueForKey:@"timeStamp"] description]]]) {
        [executedExercises addObject:[NSString stringWithFormat:@"%@",[[object valueForKey:@"timeStamp"] description]]];

    }
    [autoExecutedExercises addObject:[NSString stringWithFormat:@"%@",[[object valueForKey:@"timeStamp"] description]]];
    //[autoExecutedExercises addObject:[NSNumber numberWithLong:indexPath.row]];

    if (indexPath.row == 0) {
        NSUserDefaults *userDefaults = [NSUserDefaults standardUserDefaults];
        long warmUpTime = [userDefaults integerForKey:@"WarmUpBackup"];
        NSLog(@"warmupBackUp: %li", warmUpTime);

    }

}

Red Zone Image

A: What did you do exactly in tableView:didSelectRowAtIndexPath? Due to the reuse cell mechanism, invisible cells may not exist if you try to get them in tableView:didSelectRowAtIndexPath.

A: Don't abuse the UI system. You don't need to tell the table view delegate that a cell is going to be and then has been tapped on, you can just present the view controllers you require directly (call the method that presents without bothering the delegate).
You have the data that goes into the table view and you should be using that directly. Funnelling everything through the UI code is a burden and an application of knowledge and cross coupling in the code where there should be none.
If you wanted to show the table rows as selected, set a flag for the selected item in the data model (band scroll / reload the table). Now when the table is refreshed you can mark the cell.


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import os
import csv
import json
import pymongo
from kagen import utils
from datetime import datetime
from kagen.utils import config

logger = utils.get_logger("spreadsheet")
dir_data = config["paths"]["dir_data"]

def work(errors):
    key = config["keys"]["google_docs"]
    gid = config["keys"]["google_docs_id"]
    doc = load_doc(key, gid)
    errors = utils.load_json("{}{}".format(dir_data, errors))
    fix_doc(doc, errors)

    db = utils.get_conn_mongo()
    db.spreadsheet.drop()
    db.spreadsheet.insert(doc["data"])

def load_doc(key, gid):
    fields = ["serial", "added", "created", "title", "subject", "topic", "sub_topic", "tutorial", "titled_id", "duration", "subtitled", "ytid_en", "ytid_ar", "ytid_am", "ytid_bi", "ytid_ba", "ytid_bu", "ytid_cz", "ytid_da", "ytid_de", "ytid_es", "ytid_fa", "ytid_gr", "ytid_he", "ytid_it", "ytid_ja", "ytid_ki", "ytid_ko", "ytid_mo", "ytid_ne", "ytid_no", "ytid_po", "ytid_pr", "ytid_pp", "ytid_pu", "ytid_ru", "ytid_sr", "ytid_si", "ytid_sh", "ytid_ta", "ytid_te", "ytid_th", "ytid_tu", "ytid_uk", "ytid_ur", "ytid_xh"]
    doc = utils.get_video_csv(key, gid)
    doc = [s for idx, s in enumerate(doc.splitlines()) if idx >= 6]
    reader = csv.DictReader(doc, fields, delimiter=",", quoting=csv.QUOTE_MINIMAL, quotechar="\"", strict=True)
    jdoc = {"data": [row for row in reader]}
    return jdoc

def fix_doc(doc, errors):
    for video in doc["data"]:
        ytid_en = video["ytid_en"]
        if ytid_en in errors["ids"]:
            video["ytid_en"] = errors["ids"][ytid_en]["ytid"]
        video["_id"] = video["ytid_en"]
        video["created"] = datetime.strptime(video["created"], "%m/%d/%Y")
        video["added"] = datetime.strptime(video["added"], "%m/%d/%Y")
        video["serial"] = int(video["serial"])
        video["duration"] = int(video["duration"])

@utils.entry_point
def main():
    logger.info("START spreadsheet")
    work("mapping-errors.json")
    logger.info("DONE spreadsheet")

redpajama_set_name: RedPajamaGithub


Whirlpool Corporation is the world's leading manufacturer and marketer of major home appliances. They recognize that consumers lead busy, active lives and continues to create solutions that help consumers optimize productivity and efficiency in the home. The new whirlpool dishwashers utilize the resource efficient wash system for better efficiency and quiet performance. With features like Jetclean, Increased capacity, Hard Food Disposer, Steam Sani option and Extra Dry Option.
The PowerScourTM lets you forget soaking and scrubbing. It has 40 targeted spray jets in a designated wash area, they scour away baked-on foods and delivers twice the coverage to clean large pots and pans without using an additional drop of water.
They have the industry-exclusive EZ Adjustable tines that offers twice the space between tines, so that you have the space you need where you need it to fit larger bowls for optimal cleaning.
From baked-on casserole dishes to drinking glasses, the Sensor cycle has you covered. It automatically selects the appropriate cleaning and drying level to optimize cycle duration by using two separate sensors to measure temperature, soil level and load size during prewash and wash cycle. It cleans tough soils while using just the right amount of time, energy and water.
The Universal Cut Out Design of the dishwasher is shorter, so it fits perfectly in your remodeled kitchen, without sacrificing overall tub height or capacity. (Minimum height 33 1/2 inch).
These dishwashers are ENERGY STAR Qualified that is they exceed government efficiency standards, so they are better for the environment and your wallet.
The new improved AnyWareTM Plus silverware basket now holds up to 12 more pieces of silverware for maximum flexibility and is designed to clean better.
Their quietest line of dishwashers are equipped with our Quiet PartnerTM sound packages and sound-reducing insulation, offer quiet sound levels as low as 51 DBA.
It has the premium rail system features wheels on each side of the rack for improved gliding. Wheels fit tight into rails for a smooth feel that slides easily and quietly.
The Tall Tub design allows you to load tall and odd-shaped items in both racks. An additional 3 inch of interior space compared to standard tub models makes room for extra-large items in the lower rack and plates or sports bottles in the upper rack.
Whirlpool's latest innovation is the AquaLiftTM technology. AquaLiftTM is a self-cleaning technology that uses 250-degree heat and a new oven-cavity enamel coating to clean without fuss or fumes. All you have to do is before cleaning remove the racks, scrape off excess debris, and pour two cups of water into the bottom of the cavity and after less than an hour, the cavity needs a wipe-down.
According to consumer reports, models that come with AquaLiftTM also feature a flat door with a larger viewing window – possible. The oven cavity is slightly large. And since the traditional self-clean cycle's temperature over heats circuitry, the range requires less servicing.
Whirlpool brand places the bake element beneath the oven floor, creating a smooth, even surface that is easy to wipe clean because exposed bake elements have an irregular surface with hard-to-reach areas that are difficult to keep clean.
With Whirlpool's 6.2 cu. ft. and 5.8 cu. ft. capacity gas ranges you can cook multiple dishes for a large family meal or prepare treats for a bake sale. You can achieve uniform baking results every time with the AccuBake® temperature management system it is a built-in sensor that monitors oven temperature and controls the cooking elements to deliver consistent results. Keep the heat inside your oven while checking on dishes when cooking without opening the door with the EasyViewTM extra-large oven window.


This year is the 100th anniversary of the first Bollywood movie.
I was never a fan of Bollywood as a kid. In fact, I hated it. We had one TV and video recorder in the house (not like today) and the last thing I wanted was such dull competition for its use.
In my house, Bollywood also provided nostalgia for the Non-Resident Indian diaspora that was my parents, and it also doubled as cultural re-education for an increasingly Westernised younger generation. But there were no subtitles, so I could barely follow the plot, and the films were normally three 'boring' hours long.
My only exception was the films of Amitabh Bachchan, and his contemporaries, consistently voted one of the most popular stars on the planet. His films were the stuff of legends for young men looking for a 'cool' violent action flick that they could watch with the blessings of their parents.
The extraordinarily popular Sholay (1975) cemented his early stardom and he is still going strong today, albeit with more sedate roles. This particular era of Bollywood was also something you could laugh at (ie poor production values, physically impossible stunts, glaring continuity errors) and, trust me, we often did!
But then something changed in Bollywood.
It started to invest more in production, script and distribution to the point where films like Dil Se (1998) made it into mainstream UK Box Office top ten. Taal (1999) had its worldwide premiere in Leicester Square and Devdas (2002) became the first Bollywood film to be shortlisted for the Cannes Film Festival.
The new Bollywood started to bring edgy scripts, new audiences, and even hybrid films like My Name is Khan (2010) which tried to entertain those from either side of the ocean.
Bollywood has evolved in confidence and chutzpah to the point that it can now poke fun at itself in the wonderfully self-referential pastiche that is Om Shanti Om (2007) and in the tongue-in-cheek Dabangg (2010). In short, Bollywood became fashionable and it was infectious.
But I also changed as a person. I started watching the odd Bollywood film on DVD, with subtitles, and found it most accessible. I went to the cinema to watch other Bollywood films and found that there were plenty of non-Indian members of the audience taking pleasure from a genre that I spent years distancing myself from.
Bollywood had moved on and I had been left behind – and I don't like being left behind! Nowadays I can easily sit through a whole Bollywood film with my own family, I just hope I am not imposing it on them in the same way as it was imposed on me!


text:
/ Posts Tagged "postnup"
Mediating "Prenups" and "Postnups": Protecting Your Money While Preserving Family Harmony
April 19, 2013 Ted Rechtshaffen	Family Law, postnup, prenup
The landscape of marriage has changed dramatically over the last few decades. People are marrying later, deferring children and home ownership until their mid-to-late 30s, struggling with debt, and divorcing in record numbers.
When married people separate, the division of family assets can be one of the largest legal minefields they face.
The Ontario Family Law Act, which governs the division of property on marriage breakdown, provides that all property and debt acquired between the date of marriage and the date of separation is to be "equalized", or shared equally.[i]
This provision was meant to ensure fairness, and to recognize and compensate both spouses for all contributions to the marriage – both financial and non-financial. Unfortunately, however, the result can often feel very unfair.
Why? Because under the legislation, not all property is treated equally.
Specifically, there's a loophole in the law that can come as a rude surprise: While separating spouses generally don't have to share any pre-marriage, inherited, or gifted property with their exes on marriage breakdown, there's one major exception that people usually don't know about.
That exception relates to the "matrimonial home".
Here's the law: If you bring equity in a home into the marriage, and you and your spouse are still living in that home on the date of your separation, guess what? Your spouse gets half the total equity on the date of separation…including half of the equity you built in the period prior to marriage. And if you inherit or receive money during the marriage and use it to buy or add equity to a matrimonial home (and this includes a cottage – you can have more than one matrimonial home), the inherited or gifted money also goes into the family pot on separation.
This rule can lead to some very unfair outcomes.
Here's a fictitious scenario I've encountered, in one form or another, many times in my practice. Jane and Bill, who are in their late 30s, receive a loan of $400,000.00 from Jane's 65-year-old mother to buy a house. The loan is not properly documented and no agreement is signed. A year later, Bill leaves Jane for another woman – and takes $200,000.00 of Jane's mother's life savings with him. He denies that the money from Jane's mom was a loan, and since Jane can't prove it, the judge's hands are tied.
Now imagine that Bill also received a gift of $400,000.00 from his parents during the same period. Bill could have used that money to pay down the family's mortgage, but he didn't. Feeling ambivalent about his marriage at the time, and having wisely sought legal advice, Bill kept the money invested in a mutual fund, so that it would be excluded from division if and when he ended his marriage.
Thus, as a "reward" for his duplicity, Bill walks away with $600,000.00 – all of his money plus half of Jane's mother's money. On the other hand, Jane still has a $400,000.00 debt to her mother but now only has $200,000.00 with which to pay her back.
Sadly, I see variations on this theme all the time.
The only way to avoid these outcomes is to negotiate a solid marriage contract (or "prenup"/"postnup") before investing any "separate" funds into a matrimonial home. Anyone who brings money into the marriage, inherits money, or receives money from family, and doesn't negotiate and sign a prenup/postnup is taking a massive risk. And any parent who gifts money to his or her child and doesn't insist on a prenup/postnup is also taking a massive risk.
But negotiating prenups and postnups can be very thorny.
Traditionally, the spouse who wants the contract (or that spouse's parents) hires a lawyer to protect his or her assets. That lawyer usually prepares the contract in his or her office, according to the client's instructions, and then presents it to the less wealthy spouse in a manner that is often perceived as cold and insensitive. This leads to hurt feelings, ill will, and potentially irreconcilable, long-term family conflict.
A mediator, on the other hand, takes a different approach. A mediator who is also a lawyer not only knows the law, but can also help the parties negotiate a fair agreement together, on terms that satisfy everyone's financial and emotional interests, and in an atmosphere that allows each party's goals and needs to be expressed honestly and productively. Each party still gets independent legal advice at the end, but because they feel they've both had a voice in the creation of the document, the advice is often a 'rubber stamp' rather than the first step in an adversarial process.
Study after study shows that parties are more likely to respect and adhere to a contract they've both had a voice in negotiating – as opposed to one they feel has been imposed. As if that weren't enough incentive to use mediation, the process itself costs a small fraction of the amount people spend on traditional legal processes. Best of all, a negotiated agreement gives families peace of mind, which is priceless.
Mediation has been used successfully for decades to resolve the legal issues arising from marriage breakdown. For all the reasons discussed above, it is high time forward-thinking families used this process to negotiate marriage contracts as well.
Rosanna Breitman, B.A., LL.B., LL.M., Acc.F.M. is a partner in a Toronto law firm specializing in Family Law. She is also affiliated with the court-based family mediation clinics in both Toronto and Brampton. Her practice is restricted to family mediation and personal and organizational conflict resolution consulting. She can be reached at rosanna@torontofamilylaw.com
[1] The discussion in this article pertains only to legally married couples in Ontario. The scheme for common-law couples differs, and the legislation pertaining to married couples varies from province to province.


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I'm playing a little bit of catch up on my man Craig Sager and his fabulous suits. That means that I've got two outfits to show you. The first is from last Thursday's Chicago Bulls game where Sager thought that it was dress like Bruce Pearl night. His tie looks like one of those Word Art fonts that you can choose on Power Point. Michael Irvin would be proud of this gitup.
Sager was at Tuesday's Knicks/Celtics game and tamed things up a bit. This suit is representative of his age (62-ish) and looks like something that old people in Vero Beach, Florida wear to the early bird special at Perkins. His green tie gives this a Key Lime Pie type of look to it.


text:
La Villa Müller (, ) es una villa de estilo moderno situada en Praga (República Checa). Construida en 1930, fue diseñada por Adolf Loos como una residencia privada para František Müller, copropietario de la empresa constructora Kapsa-Müller de Pilsen.

Historia
El edificio fue encargado por František Müller y su esposa, Milada Müllerová. El Sr. Müller era ingeniero y copropietario de una empresa constructora llamada Kapsa-Müller. La empresa se especializó en el hormigón armado, desarrollando nuevas técnicas constructivas. El método de diseño de Loos también estaba en transición, lo que hizo que el proyecto se realizara en el momento apropiado. Pronto, el arquitecto Karel Lhota puso a František Müller en contacto con Loos para que diseñara la villa. Lhota también contribuyó al diseño debido al mal estado de salud de Loos. Después de que se completara el edificio, Loos celebró su 60.º cumpleaños allí con un grupo de amigos.

La pareja residió libremente en la casa durante dieciocho años hasta que los comunistas se hicieron con su control en 1948. En 1968, tras la muerte de Milada Müllerová —que solo podía ocupar solo dos habitaciones de la villa— lo más significativo de sus accesorios y colecciones fue adquirido por el Museo de Artes Aplicadas y la Galería Nacional. La villa fue declarada entonces monumento cultural de Checoslovaquia. Fue usada como almacén, biblioteca y posteriormente como sede del Instituto del Marxismo-leninismo. Tras la caída del comunismo en 1989, la casa fue devuelta a la hija de los Müller, Eva Maternová, que se la vendió al Ayuntamiento de Praga en 1995, el cual la puso bajo el cuidado del Museo de la Ciudad de Praga. La casa fue restaurada en 1998 y reabrió como museo en el año 2000.

Arquitectura

Conocida por ser un innovador ejemplo de los inicios de la arquitectura moderna, la Villa Müller encarna las ideas de Loos de economía y funcionalidad. Su diseño espacial, conocido como Raumplan, es evidente en las partes a diferente altura de cada habitación, que indican su función y su importancia simbólica. El Raumplan se puede percibir tanto en el interior como en el exterior. Tal y como afirmó Loos en 1930 en una conversación:

El exterior mostraba la teoría que Loos expuso en su célebre ensayo de 1908 Ornamento y delito, en el que critica las superficies decoradas. Para el exterior de la Villa Müller, Loos diseñó una fachada cúbica blanca. También quería hacer una clara distinción entre el exterior, que podía ser visto por el ojo del público, y el interior, compuesto por los espacios privados de las personas que residían allí. En consecuencia, el interior está decorado suntuosamente con muebles cómodos y superficies de mármol, madera y seda.

Colomina: espacio y sexualidad
La historiadora de la arquitectura Beatriz Colomina analizó la Villa Müller en el libro Geografía sexual (1992), que se centra en las relaciones entre la sexualidad y el espacio arquitectónico. El ensayo de Colomina, El muro dividido: voyeurismo doméstico, discute el posible propósito de las ventanas opacas de Loos en la casa. Colomina también menciona la concepción de Loos del palco como un espacio claustrofóbico si no fuera por el gran espacio abierto que puede contemplarse desde él.

Según Colomina, el palco podía significar poder y control dentro de la casa. Loos diseñó una sala de estar elevada que Colomina interpreta como el palco, así como el espacio «femenino» debido a su carácter doméstico. Además, Colomina sugiere que el espacio «femenino» es considerado privado y contrasta con los espacios públicos «masculinos» de la casa. El palco atrae la atención, y al mismo tiempo su ocupante está mirando hacia fuera; la persona que mira hacia el palco ve el espacio más íntimo. Por tanto, la persona en el palco es cosificada.

Véase también
Villa Tugendhat
Villa Savoye

Referencias

Bibliografía

Enlaces externos

Monumentos culturales nacionales de la República Checa
Museos de Praga
Edificios y estructuras de Praga
Edificios y estructuras terminadas en 1930
Arquitectura moderna
Casas museo


text:
Ali Kahramanlı. Born on 1 January 1953, Gaziantep. President of Mersin İdmanyurdu SK from 2008 to present. He is a Gaziantep born transportation businessman who owns Kahramanlı Group.

Business
Kahramanlı is a businessman who is interested mainly in transportation. He is the owner of Kahramanlı Group. Ali Kahramanlı has inaugurated transportation services in 1970's. Kahramanlı Group first step was taken in Mersin in 1992, with the foundation of Kahramanlı International Transportation Co. Ltd. In addition to transportation services Group runs warehouse facilities, logistics and insurance services.

Sports management
He managed Mersin İdmanyurdu since September 2008 till January 2016.

Notes and references

Living people
1953 births
Turkish business executives
People from Gaziantep
Mersin İdman Yurdu


text:
#include <mutex>
#include "ITerminal.h"

class LinuxTerminal : public ITerminal
{
public:
	LinuxTerminal();
	~LinuxTerminal();

	virtual bool initialize();
	virtual bool release();
	virtual bool setMode(eTermMode term_mode);
	virtual void clearScreen() const;
	virtual void setCursorPos(int x, int y) const;
	virtual void output(const std::ostringstream & oss) const;
	virtual bool pollKeys(kb_codes_vec & kb_codes);
};

#endif // LINUXTERMINAL_H


text:
National Institute of Environmental Health Sciences (NIEHS)
National Human Genome Research Institute (NHGRI)
Utilizing In Vitro Functional Genomics Advances for Gene-Environment (G x E) Discovery and Validation (R01 Clinical Trial Not Allowed)
RFA-ES-20-018
The purpose of this funding opportunity is to solicit applications that fully integrate recent innovative advances of in vitro functional genomics tools/technologies and approaches for environmental health and toxicology research. The overall goal of this NIEHS led initiative is to generate proof-of-principle studies incorporating these new in vitro approaches, together with well characterized exposures, to further our understanding of gene-environment (G x E) interactions in complex human disorders.
Many complex human diseases are known to involve multiple, potentially interacting genetic and environmental factors. Gene-environment (G x E) interaction or interplay is interchangeably used for the purposes of this FOA. G x E is defined broadly as a varying effect of an environmental exposure(s) depending on genetic background (susceptibility) of an individual or the stimulation of a gene variant(s) to cause disease phenotype or dysfunction only under certain environmental conditions.
Human epidemiology studies that aim to identify any interplay between genetics and environmental factors face many challenges. Foremost is the need for large sample sizes to detect an exclusive G x E association, relative to main effects, and the need for the study population to exhibit a range of both genetic and environmental variation. Consortium approaches to increase power can face difficulties in the harmonization of exposure measures and unevenness in quality of exposure assessments across different study populations. Addressing the temporality of exposures and compound mixtures brings additional complexities. Patterns of linkage disequilibrium and genetic and phenotypic heterogeneity can also reduce power to identify potential causal variants. Finally, the location of most GWAS hits in non-coding regions hinders mechanistic interpretation, and this is even more true for G x E findings with non-coding variants.
Despite these challenges, epidemiology studies supported by NIEHS and other NIH Institutes have revealed a few intriguing G x E interactions associated with several complex diseases. These potential G x E interactions were often identified through unique human population studies (with specific exposures, ethnic backgrounds, or rare disease phenotypes), making it extremely difficult to replicate or validate many of these limited G x E findings in other appropriate human populations. New approaches to therefore both identify and validate gene-environment (G x E) paradigms relevant to human disease are sorelyneeded.
Recent advances in a variety of in vitro functional genomics approaches can provide additional avenues to experimentally characterize and further interpret both newly identified as well as existing G x E findings. In vitro functional studies can further dissect susceptibility loci in physiologically relevant cells to elucidate underlying G x E mechanisms/AOPs (Adverse Outcome Pathways) driving complex diseases. These approaches can lead to a better understanding of specific response pathways that elicit or drive cellular/tissue dysfunction following environmental insults. The following in vitro functional genomics approaches, tools, and technologies may be particularly pertinent examples for dissecting G x E interactions:
Single Cell Analyses and Innovative Culture Systems:
A variety of new single cell analyses allow greater insights into cell-type specific responses to exposures, particularly in heterogeneous tissues. These single-cell studies are further advancing the understanding of somatic mutagenesis and molecular signatures generated from environmental exposures. Organoid culture models (OCMs), tissue-chip platforms, and other innovative culture systems and microfluidics have also allowed more accurate in vitro human models of many human diseases, particularly in brain and other solid organs (such as heart, liver, and lungs) from which human tissue is not readily accessible or surrogate tissue is not informative. These models may allow new paradigm shifts in the understanding of windows of susceptibility (WOS) and the role of external insults on later-in-life disease manifestations among susceptible individuals.
Population-based Models:
More sophisticated diversity cell panels from population-based model organisms (including the Collaborative Cross (CC) and Diversity Outbred (DO)) allow population-level studies to be performed in vitro. These resources have proven to be powerful tools for identifying individual quantitative trait loci (QTL) and candidate genes related to G x E interplay in complex human diseases. These cell populations are also useful for high throughput in vitro assays, toxicity screens, and functional validation experiments. In addition, populations of more mature patient-derived induced pluripotent stem cell (iPSC) models from relevant cell types could generate more detailed phenotypic endpoints to be tested. This can lead to better recapitulation of specific functions of in vivo cells (including a more thorough understanding of epigenetic reprogramming, mitochondrial functions, and xenobiotic metabolism).
CRISPR/Cas9 and Other Genome Editing Tools:
The use of CRISPR/Cas9 and other genome editing tools have the potential to generate robust high-content genome-wide screens in combination with environmental exposures of interest for probing relevant/predictable genetic variants that drive susceptibility to environmental exposures. The National Academies of Sciences 2018 workshop entitled: "The Promise of Genome Editing Tools to Advance Environmental Health Research" recommended more proof of concept and pilot studies using next gen gene-editing tools in studies with well-characterized chemical exposures to advance environmental health and toxicology research. Specific recommendations from this workshop included: the further development of in vitro assays and technologies that facilitate expanding functional endpoints beyond cell viability, the application of the next-gen gene editing tools to readily identify candidate variants that predispose differential response to the environment, and the creation of new synthetic genomes to enable novel genome-wide mechanistic research in vivo and in vitro relevant to environmental health. Workshop participants commented that although massively parallel functional assays have been utilized to understand genomic coding regions and regulatory elements, these and other higher-content assays (including CRISPR-induced saturation mutagenesis) have not broadly been combined with exposures to help characterize G x E interactions.
Integration with Omics Data:
Experimental in vitro data generated with many of these functional genomics tools and technologies can now be integrated with a variety of omics data (including transcriptomics, metabolomics, proteomics, etc.) with various annotation information (including DNAse I hypersensitive sites, ENCODE, Roadmap Epigenomics, and GTEx data, etc.). Integration of epigenomic data may be particularly valuable given that many G x E interactions are known to be mediated by environmental exposure effects on epigenetic processes. Additionally, omics data relevant to molecular phenotypes may potentially boost power for detecting G x E interactions because intermediate molecular endpoints are more tightly associated with exposure.
Integration/Application of Computational Approaches:
Integration of in vitro functional data with novel computational approaches incorporating existing biological knowledge of biochemical networks can also be extremely useful for making predictions related to G x E function. The application of rapid exciting advances in computational approaches (such as machine-learning, quantitative structure activity relationships (QSAR), and artificial intelligence/deep neural networks, etc.) to experimental data could further advance the understanding of the underlying molecular effects of G x E interactions on biological pathways implicated in environmentally-relevant disease pathogenesis. Combining in vitro data with in silico approaches can also help to prioritize variants most likely to be differentially expressed or responsive to environmental exposures.
Research Objectives/Scope:
The overall objective of this initiative is to generate proof-of-principle studies relevant to the environmental health and toxicology communities by utilizing novel high-throughput or high-content in vitro functional genomics approaches in studies with well-characterized exposures to discover or validate/refine G x E findings. A variety of in vitro approaches, resources, and strategies, such as those listed in the Background section above, could be exploited to better identify and interpret variants/pathway effects for environmentally-relevant disease outcomes.
NIEHS Environmental Exposures of Interest:
Applications are required to include an environmental chemical or toxicant having a clear link to a human disease outcome (animal or human studies) with physiologically appropriate doses/exposures considered for the species under consideration. Environmental agents which are considered of primary interest for NIEHS include: industrial chemicals or manufacturing byproducts, metals, pesticides, herbicides, air pollutants and other inhaled toxicants and particulates, as well as biologically derived toxins. The following factors should not be used as the sole environmental risk factor proposed for a study but can be used in combination with other relevant environmental chemical exposures or toxins/toxicants:
microbiota variation
psychosocial factors
dietary/exercise factors
NCI Environmental Exposures of Interest:
Exposures relevant to NCI could include but are not limited to: endocrine disrupting chemicals (e.g., BPA, phthalates), per- and polyfluoroalkyl substances, and polyaromatic hydrocarbons, as well as lifestyle and behavioral exposures.
Applications responding to this FOA may focus exclusively on validation of existing G X E or on discovery of new G X E. Applications that combine discovery and validation are also appropriate.
Expectations for G x E Validation Applications:
Applications aimed at validation or further characterization of existing G X E findings must also include:
*Preliminary data or substantial cited published literature demonstrating an existing G x E "hit" and its relevance to a human disease outcome
*Studies using at least two independent in vitro functional genomics tools or technologies (examples included in Background above)
*Use of multiple independent validations (in different species/strains/animal or cellular systems) and/or multiple cellular/molecular readouts (gene expression or miRNA changes, proteomic, metabolomic, epigenomic analyses, etc. ) to ensure robust validation of the G x E findings
*Consideration of cellular or tissue-specificity context, which could include traditional reporter assays, CRISPR-based editing, or various cellular or organelle-specific phenotype assessment
Validation applications are strongly encouraged to include:
*Some in vivo validation of in vitro findings (with appropriate animal model, human population, etc.)
*The use of novel functional genomics approaches and the development of new assays, technologies, or methods that further facilitate the expansion of in vitro functional endpoints and readouts (beyond cell viability and other crude measurements) relevant to disease phenotypes
*The inclusion of a human component (human cells, biospecimens, biomarkers in human samples, etc.) for human disease model translation
Expectations for G x E Discovery-Based Applications:
Applications aimed at discovery of a G x E interaction must also include:
*Biological plausibility for the association of gene pathways/exposures with human disease outcomes supported through preliminary experimental animal or human data and/or appropriate relevant literature citations
*At least two independent in vitro functional genomics tools or technologies (examples included in Background above)
Discovery-based applications are strongly encouraged to include:
*The utilization of novel functional genomics approaches and the development of new assays, technologies, or methods that further facilitate the expansion of in vitro functional endpoints and readouts (beyond cell viability and other crude measurements) relevant to disease phenotypes
Expectations for Combined G x E Discovery and Validation Applications:
Applications that include both discovery and validation of G x E must meet the expectation criteria, described above, for both discovery and validation.
Additional Considerations:
Novel computational approaches to use the biological knowledge gained in the application to ultimately inform or better predict G x E function and/or integration of experimental data with prior knowledge of biological networks/systems computationally is encouraged as appropriate. However, applications that are solely focused on in silico analyses, modeling, statistical methods, or computational approaches alone without in vitro experimental data will not be considered responsive to this FOA. In addition, tissue-chip platforms, tissue models, OCMs, or multi-tissue iPSCs platforms should already be established/validated as an appropriate model; the application should not be primarily focused on development of a new tissue or organotypic culture model. Multiple PD/PI projects are encouraged to promote a multidisciplinary or transdisciplinary approach, particularly with respect to combining environmental health expertise with other disciplines. Applications should also incorporate a strong data management plan and sharing expectations so that these studies could be made readily available to the scientific community in a timely fashion. Additionally, NCI specifically encourages applications focused on research that incorporates biological and genetic information from population-based studies to provide insights into the interplay of germline genetic variation and exposures and how these contribute to cancer risk and outcomes; projects with potential for human disease translation are strongly encouraged.
Specific Areas of Research Interest:
Examples of in vitro functional studies responsive to this FOA include but are not limited to those listed below:
Chemical interrogation of genetically diverse well characterized cell populations (cells or cell lines generated from rodent diversity panels, patient-derived cells, panels of isogenic human iPSCs from relevant tissues, etc.) with genome/epigenome editing tools to identify and validate genetic variants responsible for environmental sensitivity or susceptibility to environmental exposures
Use of in vitro functional approaches/assays to identify regulatory variants influencing chromatin structure, gene expression, or other environmentally-sensitive molecular phenotypes to functionally inform or prioritize genetic variants for use in a genome-wide-by-environment approach
Use of in vitro functional genomics approaches with well-characterized exposure(s) to contribute to an understanding of causal specific pathological processes (neurodegeneration, DNA and mitochondrial damage, oxidative stress and inflammation, etc.) related to a prioritized G x E for an environmentally-responsive human disease outcome
The application of innovative genome-wide functional screening assays (including CRISPR-based genome/epigenome editing, single cell DNA/RNA sequencing, massively parallel reporter assays, etc.) in toxicology studies to discover and interpret disease-associated genetic variants impacting susceptibility to environmental exposures
Integration of multi-omics datasets (GWAS, EWAS, transcriptomics, metabolomics, etc.) and/or predictive modeling with in vitro exposure data to prioritize and characterize genetic variants that are most susceptible to environmental modifications in specific cell or tissue types
Use of complex tissue models or established OCMs for identifying and characterizing biological responses to toxicant exposures and developing biomarkers or molecular signatures (related to genome integrity, DNA damage response, receptor activation, xenobiotic metabolism or toxicokinetics, etc.) relevant to G x E for an environmentally-relevant human disease phenotype or pathology
NIEHS intends to commit $4 million in FY 2022 to fund approximately 6 awards.
NHGRI intends to commit $.5 million in FY 2022 to potentially co-fund approximately 2 awards.
NCI intends to commit $1 million in FY 2022 to fund one award and potentially co-fund one additional award.
Application budgets are limited to $499,999.00 Direct Costs per year.
Leroy Worth Jr., Ph.D.
Email: worth@niehs.nih.gov
Research Strategy:
Investigators proposing both discovery and/or validation studies should clearly identify and justify the functional genomics tools utilized. Validation studies should also describe how independent validations will be conducted and how cell and tissue context will be considered. Investigators should include appropriate rationale for how the studies will ultimately inform human population studies and human disease/disorder relevance. If validation with other model organisms is proposed (particularly lower model organisms such as C. elegans, fish, Drosophila, etc.), strong rationale for the choice for any model organism system(s) should be clearly articulated, and justification for how any lower model organisms and orthologous gene pathways are known to be involved in human disease must be provided. The choice and rationale for the exposure(s) utilized and study design(s) incorporated should also be justified (with appropriate support for biological relevance of the dose(s) of the exposure chosen as well). The applicant should describe controls, plans to reduce bias (blinding, randomization, inclusion and exclusion criteria, etc.), power analyses, and statistical methods as appropriate. The applicant should justify animal numbers, including reference to appropriate statistical methods for power and sample size calculations. Appropriate justification should be given if only one sex is considered in the study design, including details regarding given exposures (dose range) for the single sex that is being interrogated.
Investigators are expected to include data management and sharing plans to ensure that the datasets generated are made readily available to the scientific community in a timely fashion. Submission of data to relevant publicly accessible databases (for example, FlyBase, JAX Mouse Phenome database, etc.) is highly encouraged, and plans should describe how data can be adapted broadly for use by the environmental science community. Plans for data management and sharing will be discussed during the initial scientific merit review. Other biological resources (tissues, samples, etc.) as well as unique protocols and study designs should also be shared when feasible to the broader scientific community.
All applications, regardless of the amount of direct costs requested for any one year, should include a detailed Data Management and Sharing Plan, addressing the following elements:
A statement expressing the investigator's commitment to sharing their data. At a minimal level, data forming the basis of each scientific publication from such research should be made publicly accessible.
Description of the type and amount of digital data to be collected or produced over the life of the proposed project.
Description of the data to be shared and the rationale for selecting those data for sharing (i.e. raw vs processed data, aggregate vs individual level data).
Description of data standards, including formats, data identifiers, metadata, and other data documentation to be used for collected data and rationale for their selection.
Description of mechanisms for providing access to or sharing data. Use of publicly accessible data repositories is encouraged (such as MMHCC, MMRRC, etc.).
Delineation of who will be responsible for data management, both during data collection and analysis and after the completion of the project, if applicable.
Milestones and timelines for making the data publicly accessible. It is expected that data forming the basis of each publication linked to this award will be submitted and made available for sharing no later than the time of publication date.
Describe any data sharing agreements, licenses, and other data sharing restrictions or use limitations.
Indicate whether specialized tools and/or software are needed to access or manipulate shared data to support replication or reuse and specify how the needed tools can be accessed.
Applications proposing generation of genomic data should include descriptions of data sharing that are consistent with the NIH Genomic Data Sharing Policy (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-124.html). Human genomic data is strongly encouraged to be submitted to dbGaP if study consents allow, regardless of sample size.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete, non-compliant and/or non-responsive will not be reviewed.
In order to expedite review, applicants are requested to notify NIEHS by email at worth@mail.nih.gov when the application has been submitted. Please include the FOA number and title, PD/PI name, and title of the application.
Will relevant/important insights underlying the mechanisms of a new or existing G x E finding likely be accomplished at the conclusion of the project? How relevant will the findings be to a human disease outcome(s)?
To what extent do the PD(s)/PI(s) and other key personnel have adequate expertise in genetics, genomics, computational and bioinformatics methodologies, molecular biology, biochemistry, cell physiology, analysis of genome-wide data, high-throughput experimental protocols, toxicology, environmental exposure assessment, environmental epidemiology, animal models, and/or other fields relevant to the project, as well as expertise in and understanding of the mechanistic complexity of the environmentally-relevant disease of interest? Do the investigators have complementary and integrated expertise and skills? How facile are the PD(s)/PI(s) in curation of large data sets, including multiple layers of complex genomic data relevant to genetic analysis? How facile are the PD(s)/PI(s) in the understanding and management of functional genomics and environmental measure outcomes?
Does the application propose novel or unique in vitro genomic functional approaches to characterize the biochemical, physiologic, and regulatory roles of functional genomic elements with an appropriate environmental exposure? Are the proposed concepts, approaches, methodologies, instrumentation, or interventions in the application new to the field of environmental health research? Does the application utilize and/or develop new or improved robust and/or high-throughput genetic and epigenetic screening techniques, methods, or assays? Are any approaches proposed that improve on functional endpoints and readouts for in vitro studies? Are the uses of model organisms, culture models, or tissue-chip platforms in the application allowing new paradigm shifts in the current understanding of the impact of environmental exposures in complex disease development?
How effectively will the project use novel in vitro functional genomics approaches to expand our mechanistic understanding of G x E interactions relevant to a disease or organ/tissue dysfunction outcome? Is there sufficient biological plausibility or evidence (for validation applications) of a proposed G x E interaction between gene pathways/exposures (or AOPs) with disease outcomes or organ/tissue dysfunction? Does the application propose adequate and robust plans for experimental validation of function(s) and identification of underlying molecular mechanisms? Does the project adequately address issues of statistical power?
Are the facilities/resources commensurate with the proposed study design along with appropriate core facility expertise/infrastructure? Are the computational informatics facilities and data management infrastructure sufficient for what is proposed?
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NIEHS, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.
Kimberly A. McAllister, PhD
Email: mcallis2@niehs.nih.gov
Stefanie Nelson, PhD
Email: nelsons@mail.nih.gov
Rongling Li, MD, PhD, MPH
Email: lir2@mail.nih.gov
Leroy Worth, PhD
Jenny Greer
National Institute of Environmental Health Science (NIEHS)
Email: jenny.greer@nih.gov
Deanna L Ingersoll
Email: deanna.ingersoll@nih.gov
Email: wolfreyc@gab.nci.nih.gov