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Mental Performance
Strength for Girls
JC Moreau
Mike Gillette
Strength For Girls – The Strength U Approach
By JC MoreauJuly 8, 2017December 14th, 2021Uncategorized
BY: JC Moreau, Director of Sports Performance, Strength U
Coach Moreau's Best-Selling Book, The Parents Guide To Sports Performance Training. Available on Amazon.com
All Big Ten Guard Kristy Smith (2009)
Coach Lisa Bluder Testimonial
Moreau and the 2008 Iowa Women's Basketball Team after winning the 2008 Big Ten Regular Season Championship
CCA HS & Iowa Rocket Alyssa Weldon
Strength U. is pleased to provide the nation's most comprehensive sports performance training for girls. Coach JC Moreau draws upon his unique experiences training women, ranging from complete beginners through Olympic Gold medalists, to develop the customized training programs designed using the Strength U. mantra of "Strong Mind • Smart Body". The purpose is always on training flawless movement patterns, technique, and power and speed mechanics, while simultaneously developing confident, mentally strong, focused and resilient young women. Coach Moreau's professional experiences and responsibilities would certainly classify him as one of the ten most qualified performance coaches for female athletes in the nation. When his expertise training female athletes is combined with his passion for helping young athletes maximize their potential, strengthen their mental resolve, and come to the realization that they are capable of far more than they realize, when they understand the value of preparation.
IC West High's Brylee Klosterman making solid contact in a Varsity game in '16 as a rising FR.
Coach Moreau has 15 years of experience training NCAA Division I female student-athletes, and has trained nationally-ranked (Top 25) volleyball, basketball, softball, soccer, track & field, swimming, diving, cross-country, lacrosse, field hockey, ice hockey and golf teams during his tenure at Colgate University, Lafayette College, the University of Memphis, the University of Arkansas and the University of Iowa. At the University of Arkansas, he was the Head Strength Coach for Women's Athletics (one of only two coaches in the nation to hold that title) and at the University of Iowa he was the Director of Strength & Conditioning. During his time at Arkansas, Moreau worked with several NCAA tournament teams, NCAA national champion, Stacy Lewis (currently the #2 ranked women's golfer in the world) and Veronica Campbell (a five-time Olympic Gold medalist in the 200m dash and 4x100m relay). While at Iowa, Coach Moreau worked with a women's basketball team that qualified for the NCAA tournament each of his four years, winning the Big Ten regular season title in 2008 and finishing no lower than third in the conference each season. Finally, in 2010 Moreau and his staff held the first ever strength training and injury prevention clinic exclusively for girls, with over 250 athletes, parents and coaches in attendance, for the FREE instructional clinic. In response to the clinic's success Moreau went on to hold three more similar clinics across Iowa, to educate coaches and parents to the protocol for injury reduction he and his staff had developed.
His thousands of hours of practical experience and specialized study of the specific needs and challenges for females pertaining to developing lean, toned muscle while maintaining ideal body composition, correcting some of the muscular imbalances and asymmetry commonly found in women and implementing a sport-specific training protocol that seeks to strengthen areas that require particular attention in females who play particular sports are among the resources he uses to help each girl reach her potential.
"J.C. is one of the elite Strength and Conditioning Coaches in the United States. He pushes his athletes to better themselves everyday whether that is in the weight room or in their everyday life. His ability to connect with every athlete in a different way is what separates him from everyone else. J.C. loves what he does and it shines through every day."
Kachine Alexander- Asst. Coach, North Dakota State University, 2011 All-American, WNBA Draft Pick and 2010, 2011 All-Big Ten Selection for The University of Iowa
Whether it is basketball, volleyball, softball, soccer, cheer, dance, golf or ice hockey, Moreau and his staff will develop a program to maximize each athlete's speed, acceleration, agility, change of direction ability, mechanics, explosive power (jumping), landing mechanics and strength. Most importantly, though, every program incorporates a proven protocol to prevent the potential for non-contact injuries such as ACL tears. Lastly, Moreau is far more than a "trainer" but a wildly successful coach who prides himself on educating young women on why his methods are so critical, as well as addressing important intangible qualities such as confidence, resilience, selflessness, teamwork, self-esteem and body image (if appropriate). In short, Moreau uses strength training as a way to build girls up, both physically and psychologically.
Moreau began to champion the cause of improved strength training for girls, to decrease the rate of injury, improve performance at a rate equal to that of their male peers and because of the tremendous value he believes it has in developing strong, confident female leaders. He and his wife Niki are now the proud parents of three daughters (Carly four, and two year old identical twin sisters Brooklynn and Blaykely), so it goes without saying that this is not an issue that he plans to place any less focus on over the years to come.
Sport/Age/Gender-Specific Sports Performance Coaching for girls aged 10+. This includes general movement assessments (Full Functional Movement Screen with 10 page pdf findings available at additional cost), corrective work for structural imbalances, proper and safe instruction of strength and power training exercises using a proven progression to allow all levels of trainee work at the appropriate skill and intensity level, speed, acceleration, deceleration, change of direction, running mechanics and more. Always with injury prevention and physical resilience being the top priority.
ACL Injury Prevention: Whatever your age or skill level, our team will perform a comprehensive series of strength, balance, and functional movement assessments. From there, we create an all-inclusive, personalized plan to strengthen and stabilize your body, address the specific risk factors presented by your sport, and reduce the risk of ACL injury.
Plyometric and other explosive jump training, always incorporated under the strict protocol established by Coach Moreau after 15+ years of experience training several thousand NCAA Division I and High School female athletes.
Nutritional consultation provided (ONLY WHEN PARENTS ARE FIRST CONSULTED and at an additional cost) using the performance nutrition program Moreau developed in a collaborative effort with MDs from the UI Sports Medicine staff and PhDs from the University's Dietetics Department. Our philosophy involves learning about each individual's nutritional background, experiences and current habits, and addresses those most relevant from a health standpoint first. We strive to educate and work to develop an understanding of how our diet impacts our health and performance and seek to make improvements by breaking bad habits and developing new ones, usually one at a time. There is no mention of "Diet" as we believe the only way to achieve long term success is through proper education and the creation of new habits, which are only chosen once the athlete feels confident in her desire to make this change. This leads to a much higher success rate when compared to the traditional "yo-yo" effect that most experience when attempting "Fad Diets" which demand drastic overhaul that is simply not sustainable.
Consultation/Team Coaching is available to individuals and teams, and parents/coaches are ALWAYS involved! Please call to receive a quote as fees are based on time, travel and size of group and will vary.
Small Group and Team Training are all available so that each athlete is able to obtain the level of attention they require, while considering the resources available are different in each situation.
Off-Site Team Training is available when scheduling allows. We take the facility to your school or club practice space and conduct sessions on your home court or field! This is a great way for parents and coaches to save significant time, keep cost lower and have their entire team benefit
Call or email us today at JC@TheStrengthU.com or 479-530-8254 to see why Strength U provides science based, athlete-centric sports performance training for girls that has been proven effective where it matters most; in the gym, on the field or in the weight room! These methods have only been made available to a select few, so do not miss out on this truly unique, and possibly career changing opportunity to work with and learn from an industry leader and trend-setter. There are several options of speed & sports performance training available now. Contact us to learn more.
Strength & Acceleration: The Traits Athletes Truly Covet (Revised from 2016)
The Importance of Eccentric Strength and Landing Mechanics for Volleyball Athletes
Effective Basketball Performance Training For Youth Athletes: Building a Strong Foundation for Future Success
Why It May Be Harmful For Pre-Teens to NOT Strength Train!
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What's On / News
Busan Biennale 2020 seeks Artistic Director
Busan Biennale Open Call for Artistic Director (http://blog.busanbiennale.org/)
The Busan Biennale Organizing Committee (hereinafter referred to as the committee) is holding open recruitment to select the next artistic director to plan Busan Biennale 2020. Applications will be accepted between May 15 and June 3. The committee will conduct reviews before making its final artistic director selection in July 2019. The committee previously used open recruitment to select the artistic director of Busan Biennale 2018. Numerous planners from Korea and overseas applied at the time, showing their active commitment to new discourses in contemporary art. To promote the transparent and rational management of the follow-up exhibition to Busan Biennale 2018 and discover new curators, the committee is adopting the open recruitment approach once again to select the Busan Biennale 2020 artistic director. As the 20th anniversary of the committee's establishment, the year 2020 could also be seen as an occasion for taking the next step forward in transforming one of Asia's representative biennales into a global biennale exhibition. The individual(team) selected as artistic director will be responsible for directing the exhibition—including selection of the theme, artists, and artworks and related budgeting—and for planning exhibition-related events. The artistic director will also be responsible for duties related to publicity and funding. Busan Biennale 2020 is scheduled to take place in September 2020.
http://www.busanbiennale.org/eng/index.php?pCode=notice&mode=view&idx=10314
#busan_biennale
News / What's On - 26 Sep 2017
Public museums to pay artists for work
News / What's On - 26 April 2018
2018 Gwangju Biennale
with 153 artists and 11 curators on 'Imagined Borders'

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Santa Rosa Symphony
Music; Recovery Fund Grantee
50 Santa Rosa Ave., Santa Rosa, CA 95404
The musical arts are alive and well in Santa Rosa.
Few cities in America of comparable size support a regional symphony so vital, dynamic, and innovative. As the Santa Rosa Symphony gains a national reputation for stellar sound, bold excellence and community engagement, Sonoma County forges an identity as a place in love with classical music. While others struggle merely to survive, our orchestra strives for greater depth and breadth of artistry and accomplishment by:
Maintaining the highest standard in artistic achievement
Enriching the quality of life through classical music
Inspiring our youth to appreciate and participate in the musical arts
Engaging a broader audience with both traditional and innovative programming
Establishing Sonoma County's identity as a premier cultural destination


Do you try to get involved in your kid's life but end up invading their personal space?
Do you try to get involved in your kid's life but end up invading their personal space? If this happens to you more than often, then you might be turning into a 'helicopter parent'. A helicopter parent is a type of parent who gets overly involved in their child's life. We know that you want the best for your child, every parent does but sometimes it gets too much for the child.
If you hover all the time – keep track of what your kid is doing, always following them around, directing their behaviour and giving them no time for themselves, then we hate to break it to you, but you are a 'helicopter parent'.
If you control everything that your child does, then they might get dependent on you and won't be able to handle things on their own. They will lose their confidence, and it might even damage their self-esteem.
Helicopter parents often try to solve all of their kids' problems. If there are no problems left, how will your kids learn to solve them? It is important for them to experience loss, disappointment and failure, and to cope with them on their own. It is valuable for them to develop coping skills to overcome challenges in the long run.
Helicopter parenting does not allow children to be independent. They become so used to their parents helping out with everything that they become completely dependent on them. It doesn't seem right if a 20- year-old needs his mother to wake him up every morning or do his laundry so that he does not get late for college.
Helicopter parents micromanage everything their kid does from tying their shoelace to monitoring their lifestyle. When your child has grown up and is capable of doing things on his own, then you should let them it. This might seem petty, but these lessons can benefit your child in the long run. The negative feedback of life will teach them right from wrong and make them confient.
As a parent, your actions might spoil your relationship with your child. Continuous interference in your child's life can hamper your relationship. Your child might get irritated and might even start hiding things from you. This will only push your child away from you.
How to Stop Being a Helicopter Parenting?
As parents, it is difficult to keep an eye on what your children are doing without smothering them or inhibiting their ability to learn important skills. Allow them to stumble, experience disappointment, learn to handle physical and mental stress and make them work out things on their own. This will help your kid become self-confident and strong.
For more reach articles, download OnlymyHealth app.
What are the challenges faced by Single Parents?
What are the benefits of single parenting?
Strict parenting: What are the long-term effects?


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Q: Is it possible to create an excel spreadsheet through Android Studio? I am looking to make an app that allows users to enter information into several fields, and when they submit, the data is formatted into an excel file.

A: Almost everything to create is possible. You might use TableLayout and TableRows to add new textviews columns, and also you should use database to save user's input

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How best to test for testosterone
Pharma and their dupes want to castrate you or steal your ovaries
Statin drugs don't help prevent heart attacks--American Medical Journal
LDL immune sytem role, and on Liver textbook
LDL through immune function lenghten life--journal articles
Recommended Journal Articles
Lipids and cholesterol are essential formation of
new cells
LDL and VLD have important Immune system functions. This article is one of several posted confirming what covers this and that pathogen living within the walls of arteries is the leading cause of heart attacks, atherosclerosis, and strokes. LDL and VDL are there as part of the immune system along with white blood cells. For more on this topic http://healthfully.org/rl/id8.html and http://healthfully.org/rl/id9.html or do a scholar.google.com search typing in pathogens + atherosclerosis.
LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction
Anita C.E. Vreugdenhil, A.M. Patricia Snoek, Cornelis van 't Veer, Jan-Willem M. Greve, and Wim A. Buurma
J Clin Invest. 2001 Jan 15; 107(2): 225–234.doi: 10.1172/JCI10832
LPS-binding protein (LBP) and serum lipoproteins cooperate in reducing the toxic properties of LPS. In the present study, we demonstrate that LBP circulates in association with LDL and VLDL in healthy persons. ApoB [one of two main protein on the surface of LDL] was found to account at least in part for the interaction of LBP with LDL and VLDL. Although LBP interacted with purified apoA-I in vitro, no association of LBP with apoA-I or HDL was found in serum. Consistent with the observed association of LBP with LDL and VLDL, these lipoproteins also were demonstrated to be the predominant LPS-binding lipoproteins. Most interestingly, the association of LBP with LDL and VLDL strongly enhanced the capacity of these lipoproteins to bind LPS. Because this function of LBP is of utmost importance during infection, the association of LBP and LPS with lipoproteins was also studied in serum from septic patients. In septic serum containing high LBP levels and a markedly altered lipoprotein spectrum, most of the LBP is associated with LDL and VLDL, although some LBP appeared to circulate free from lipoproteins. Also in this serum, LPS was found to bind predominantly to LDL and VLDL. The observed binding of LBP and LPS to LDL and VLDL, as well as the LBP-dependent incorporation of LPS into these lipoproteins, emphasizes a crucial role for circulating LBP-LDL/VLDL complexes in the scavenging of LPS [bacterial toxins].
LPS is a constituent of the outer membrane of gram-negative bacteria and evokes an inflammatory response by activation of monocytes and endothelial cells. LPS-induced cellular responses are the net result of the interaction of LPS with various plasma components such as soluble CD14, LPS-binding protein (LBP) and membrane receptors such as membrane-bound CD14 and Toll-like receptors. This initiation of cellular responses is essential for the host defense against bacterial infections. However, if large amounts of endotoxin are present in the circulation, an excessive cellular response can be deleterious for the host, and, therefore, endotoxin-inactivating processes are of extreme importance.
LPS is detoxified in the circulation by incorporation into lipoproteins (reviewed in ref. 1). Physiological levels of lipoproteins protect against endotoxicity in vitro and in vivo (2, 3). Early studies have demonstrated an interaction of LPS with HDL (4); albeit later, also VLDL and LDL were found to bind and inactivate LPS (5–7). Consistent with this, LDL, VLDL, chylomicrons, and HDL all have been observed to reduce the lethal effect of endotoxin in mice (8–10).
Evidence for a physiological role for LBP in inflammation is supported by studies that demonstrate enhanced mortality and uncontrolled multiplication and spread of bacteria in LBP knockout mice compared with wild-type mice after intraperitoneal administration of bacteria (11). The results of these studies indicate that LBP is required to induce a rapid inflammatory response, which is essential for the resistance to bacteria. However, LBP has the paradoxical dual function of sensitizing the immune system to endotoxin and, on the other hand, enhancing detoxification of endotoxin. LBP catalyzes the transfer of LPS into lipoproteins, thereby enhancing LPS detoxification (12). Likewise, LBP catalyzes the lipoprotein neutralization of lipoteichoic acid, a component of the cell membrane of gram-positive bacteria (13). Lamping et al. demonstrated in a murine model that high levels of LBP in the circulation, as seen during an acute-phase response, inhibit LPS effects and prevent mortality induced by endotoxemia (14). The latter observation strongly supports a physiological role for LBP-dependent detoxification of LPS in the host defense.
Endotoxemia induces an acute-phase response characterized by multiple physiological adaptations. This response appears to play a role in host defense mechanisms, although its physiological relevance needs further elucidation. One aspect of the acute-phase response is a dramatic rise in circulating levels of LBP (15). Concomitantly, large changes in serum lipid and lipoprotein concentrations occur. Circulating levels of total cholesterol, LDL cholesterol, and HDL cholesterol decrease, whereas serum triglyceride and VLDL levels increase (16). In addition, alterations in apolipoprotein levels are observed (16, 17). ApoA-I concentrations drop, and HDL becomes depleted in apoA-I (16, 18). In contrast, apoB levels are not affected by either viral or bacterial infection (16).
Others found evidence for an association of LBP with apoA-I–containing lipoproteins in plasma from healthy persons (12). We consider that the physical association of LBP with these lipoproteins may be important for the cooperation of LBP and lipoproteins in the detoxification of endotoxin. However, the strong reduction of apoA-I and HDL levels that coincides with the dramatic raise in LBP levels during endotoxemia seems in contrast with this cooperative function. Because it is firmly established that LDL and VLDL are critical in the survival of infection with gram-negative bacteria (19) and that circulating levels of these lipoproteins are relatively high during inflammation compared with HDL levels, the present study was undertaken to investigate whether LBP associates with LDL and VLDL. To this end, the distribution of LBP among lipoproteins was studied in serum of healthy and septic persons. Subsequently, we investigated the effect of the association of LBP with lipoproteins and apolipoproteins on the LPS-binding capacity.
Reagents.
LPS from Escherichia coli, serotype 055:B5, was purchased from Sigma Chemical Co. (St. Louis, Missouri, USA). Purified apoA-I and apoB were derived from Calbiochem (La Jolla, California, USA) and ICN Radiochemicals Inc. (Irvine, California, USA), respectively. Polyclonal antibodies to human LBP were obtained by immunizing rabbits with purified human LBP. Protein A–purified anti-LBP IgG was biotinylated following standard procedures. Anti-human LBP mAb HM14 was obtained by immunizing mice with LBP following classical procedures. Horseradish peroxidase–labeled mAb against apoA-I and apoB were gifts from L. Sorell (Center for Genetic Engineering and Biotechnology, Havana, Cuba).
Blood samples.
Blood was collected from healthy donors and from septic patients. Informed consent was obtained from healthy donors and relatives of septic patients. To prepare serum, blood was allowed to clot for 2 hours at room temperature. Serum was separated by centrifugation and stored at –80°C until use. Fresh serum was used for isolation of lipoprotein fractions.
Lipid electrophoresis and Western blot analysis.
Agarose electrophoresis was performed in barbital buffer (pH 8.6) using the Paragon Lipoprotein Electrophoresis kit P/N (Beckman Instruments, Brea, California, USA) according to the manufacturer's instructions. Agarose gel electrophoresis was followed by electrophoretic transfer onto an Immobilon-P membrane (Millipore Corp., Bedford, Massachusetts, USA) in blotting buffer (25 mM TRIS, 192 mM Glycine, 10% methanol) using the Phast system (Pharmacia Biotech A/B, Uppsala, Sweden). After transfer, the membranes were blocked with 1% BSA in PBS for 1 hour at 37°C and washed with 0.1% BSA 0.5% Tween in PBS. For detection of LBP, membranes were incubated with biotin-labeled polyclonal antibody specific for human LBP, washed, and incubated with peroxidase-labeled streptavidin. After detection of LBP, apoA-I was probed on the same blot after elution of the LBP antibodies by incubation with 0.1 M Glycine-HCl buffer (pH 2.5) for 15 minutes at 37°C. Localization of apoA-I was followed by detection of apoB in a similar protocol. For immunodetection of apoA-I and apoB, peroxidase-labeled mAb's were used. Interactions of LPS with serum lipoproteins were studied by preincubation of biotin-labeled LPS with human serum overnight at 37°C. After preincubation, serum was subjected to electrophoresis and blotted and membranes were incubated with peroxidase-labeled streptavidin. To study LPS binding to isolated (apo)lipoproteins, human serum was first subjected to electrophoresis and blotted and membranes were incubated with biotinylated LPS, followed by incubation with peroxidase-labeled streptavidin (Zymed Laboratories Inc., South San Francisco, California, USA). Peroxidase activity was detected by chemiluminescent substrates (SuperSignal Substrate, Pierce Chemical Co., Rockford, Illinois, USA) according to the manufacturer's recommendation.
Lipoprotein fractionation.
Lipoproteins were isolated from pooled fresh normal human serum (six healthy donors) by a 22-hour single spin density gradient ultracentrifugation at 200,000g and 17°C according to Terpstra et al. (20), using a Beckman XL-80 ultra centrifuge with a SW40 rotor and ultraclear centrifuge tubes (Beckman Instruments). A step gradient was constructed from 2 ml serum adjusted to density 1.250 g/ml with KBr and sucrose; two NaCl/KBr solutions with density 1.225 and 1.100 g/ml, respectively; and 0.998 g/ml endotoxin-free water. All solutions contained 0.1 mg/ml EDTA. The lipoprotein fractions VLDL, LDL, HDL2, and HDL3 were collected by aspiration, dialyzed extensively against PBS at 4°C, and stored at –80°C until use. Cholesterol concentrations in the isolated lipoprotein subfractions were determined using an enzymatic colorimetric test from F. Hoffman LaRoche, AG (Basel, Switzerland). The lipoprotein fractions used contained no detectable LBP as assessed by LBP-specific ELISA (15).
Purification of LBP and production of LBP-depleted human serum.
LBP was isolated from human plasma by selective-affinity immunosorption as described previously (21). Plasma from healthy volunteers was kindly provided by the local blood bank. In short, anti-hLBP mAb HM-14 was cross-linked to CNBr-activated Sepharose (Pharmacia Biotech A/S) according to the manufacturer's instructions. Human plasma was applied to the anti-LBP column, and unbound proteins were washed out with 0.5 M MgCl. Bound LBP was eluted with 0.1 M Glycine-HCl buffer (pH 2.5). LBP-depleted serum was produced by passing serum over the anti-LBP column. LBP-depleted serum contained less LBP than 0.05% of normal serum as assessed by LBP-ELISA.
Preparation of biotin-labeled LBP and LPS. And another 3 pages.
The structure and function of LBP are extensively studied; however, knowledge concerning the in vivo forms or associations with other serum components and the effect of these associations on the function of LBP is limited. In the present study, we obtained evidence that LBP circulates in association with apoB-containing lipoproteins in healthy persons and in septic patients. This association is functional, as LBP bound to LDL and VLDL was observed to enhance the LPS-binding capacity of these lipoproteins, a process known to result in protection from the deleterious effects of LPS toxicity.
In search of the factors involved in the association of LBP with apoB-containing lipoproteins in serum, we found that this interaction is at least in part mediated by an interaction of LBP with apoB. Although LBP was not associated with apoA-I or HDL in serum, our experiments demonstrate that LBP does bind to purified apoA-I. Evidence for a specific interaction of LBP with apoA-I is supported by studies by Massamiri et al., who demonstrated that binding of LBP to reconstituted HDL is partially blocked by antibodies against apoA-I (23). In the present study, we observed a tenfold higher affinity of LBP for apoB compared with apoA-I (Figure (Figure8c).8c). The amount of apoA-I molecules in serum, however, is about 30 times higher than the amount of apoB under healthy conditions, therefore, it is not possible to subscribe the predominant interaction of LBP with LDL and VLDL to the higher affinity of LBP for apoB. It is possible that LBP interacts with domains of apoA-I that are masked by incorporation in native HDL. Furthermore, other constituents than apoB may contribute to the high affinity of LBP for LDL and VLDL and consequently increase the competition for binding of LBP to HDL.
The LBP-transporting lipoproteins LDL and VLDL were also found to be the predominant LPS-binding lipoproteins in normal human serum, an observation which is supported by others (5, 24). Studies performed in rodents report the preferential binding of LPS to HDL (4, 25–27). Relatively high HDL levels in rodents seem to account for the predominant binding of LPS to HDL, as high LDL levels in Watanabe heritable hyperlipidemic rabbits and high VLDL levels in apoE knockout mice result in the predominant binding of LPS to LDL (5, 28) and to VLDL (J. Kuiper personal communication), respectively. In contrast to rodents, the HDL:LDL/VLDL ratio is low in humans, which most likely causes the differences observed for the distribution of LPS among lipoproteins in humans and rodents.
Our data further demonstrate that LBP associated with LDL and VLDL strongly enhances binding of LPS to these lipoproteins in a dose-dependent fashion. However, presence of LBP is not required for the interaction of LPS with LDL and VLDL. ApoB, present in LDL and VLDL, was demonstrated to have high affinity for LPS and therefore may account for LPS binding under LBP-free conditions. This interaction of LPS with apoB is inhibited by presence of LBP, implicating competition of LBP and LPS for apoB. It can be hypothesized from these data that apoB functions as an anchor for LBP on LDL and VLDL. This bound LBP may catalyze the binding of LPS to other lipoprotein components and thereby enhance the total LPS-binding capacity. Given that others found that a lipid-lipid interaction accounts for the association of LPS with lipoproteins (5) and have demonstrated that LBP enhances binding of LPS to phospholipid membranes (29, 30), it is likely that LBP linked to apoB enhances intercalation of LPS into the phospholipid membrane of the lipoproteins. Other proteins present in LDL and VLDL may, however, also contribute to the LPS-binding capacity of these lipoproteins. ApoE, present in VLDL, for instance, was demonstrated to bind LPS (31). Most interestingly, apoE-deficient mice display increased susceptibility to endotoxemia (32), the latter supporting a possible role for apoE in the scavenging of LPS.
During infection, lipoproteins are proven to be fundamental for the survival of the host (1, 2, 9, 10, 19). Under these conditions, lipoprotein levels and composition are known to be altered profoundly (33). These changes prompted us to evaluate the interaction of lipoproteins with LBP and endotoxins in septic serum. The changes in lipoprotein composition and the more than tenfold enhanced LBP levels did not significantly affect the distribution profile of LBP. In serum of septic patients, LBP is also colocated predominantly with apoB (Figure (Figure10).10). These observations indicate that during sepsis, approximately tenfold more LBP is associated with LDL and VLDL. This is of particular interest, as we observed that the LBP-induced upregulation of LPS binding to these lipoproteins is dose-dependent. Only a small fraction of the total LBP in septic sera migrates as free LBP. Whether there is a difference in biologic activity between lipoprotein-associated and non–lipoprotein-associated LBP in the host response to endotoxin is currently under our investigation. The predominant incorporation of LPS in LDL and VLDL is also observed in septic serum and does not seem to be influenced by the alterations in lipoprotein composition and the presence of free LBP. Our results, which indicate that LPS and LBP both predominantly bind to LDL and VLDL under septic conditions and that apoB forms a binding site for LBP and LPS, are in line with the findings of others (16) that in contrast to apoA-I, apoB levels stay high during infection. The remaining high concentration of apoB in LDL and VLDL seems functional, as it may contribute to the enhanced binding of LBP and, as a consequence LPS, to these lipoproteins during infection.
It is firmly established that binding of LPS to lipoproteins reduces LPS toxicity (3). In accordance, hypolipidemia results in enhanced LPS-induced lethality in animals (2), and in humans, low levels of cholesterol predict an increased risk of death from infection (34), which emphasizes the significance of lipoproteins in protection from bacteria and their toxins. The protective function of lipoproteins is considered to be due to an increase in the clearance of LPS by formation of LPS-lipoprotein complexes and to prevention of its binding to cells. In addition, it was recently demonstrated that lipoproteins, including LDL, also promote the release of cell-associated LPS, which was proved to be dependent on LBP (35). This inhibition of endotoxin binding reduces activation of monocytes and thereby the secretion of cytokines (3,35, 36). This protective property of lipoproteins is not only described for gram-negative bacteria, but also the toxic effects of fragments of gram-positive bacteria are inhibited by LDL, a process catalyzed by the presence of LBP (13). The beneficial role for LDL in the host defense against bacteria is supported by a study that demonstrates that LDL-receptor–deficient mice with elevated circulating LDL concentrations are protected against lethal endotoxemia and severe infections with gram-negative micro-organisms (19).
The uptake of LPS into LDL, which we consider beneficial during acute infection, should be considered as potentially harmful during chronic inflammation. Since we studied LPS binding to LDL and VLDL, and not toxicity, we cannot exclude that LPS binds to LDL and VLDL in a manner by which it retains some toxic activity. In the long term, these complexes may play a pathogenic role in the development of atherosclerosis. Although LDL protects endothelial cells from acute LPS toxicity by formation of LPS-LDL complexes, these complexes migrate across the endothelium and, via unknown pathways, increase the secretion of monocyte chemotactic activity by endothelial cells (28). [In other words, infections in the intima media of the artery walls and the LDL immune response contributes to the formation of atheroma. Thus atheroma is like the formation of a boil from the presences of bacteria, and the leakage of this boil like atheroma results in ischemic events.} As a consequence, transport of LDL-LPS complexes into the artery wall may initiate an inflammatory response and provoke an atherosclerotic reaction.
In conclusion, we found strong evidence for an association of LBP with apoB-containing lipoproteins in the circulation of healthy persons. Also in septic patients with extremely high circulating LBP concentrations, LBP is predominantly bound to apoB-containing lipoproteins. Most interestingly, LBP associated with LDL and VLDL enhances the LPS-binding capacity of these lipoproteins in a dose-dependent manner. Accordingly, in serum from healthy persons and from septic patients, LDL and VLDL are the predominant LPS-binding lipoproteins. Overall, the data of this study suggest that LBP is a cofactor of circulating LDL and VLDL, which facilitates the uptake of endotoxin by these lipoproteins. This implies an important role for LBP/LDL and VLDL complexes in the defense against bacteria and endotoxin.
We thank M. Poeze for the assistance in obtaining the serum of septic patients. This work was supported by a grant of the Dutch Digestive Diseases Foundation, The Netherlands
1. Read TE, et al. The protective effect of serum lipoproteins against bacterial lipopolysaccharide. Eur Heart J. 1993;14:125–129. [PubMed]
2. Feingold KR, et al. Role for circulating lipoproteins in protection from endotoxin toxicity. Infect Immun. 1995;63:2041–2046. [PMC free article] [PubMed]
3. Flegel WA, Wölpl A, Männel DN, Northoff H. Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins. Infect Immun. 1989;57:2237–2245. [PMC free article] [PubMed]
4. Ulevitch RJ, Johnston AR, Weinstein DB. New function for high density lipoproteins. J Clin Invest. 1979;64:1516–1524. [PMC free article] [PubMed]
5. Van Lenten BJ, Fogelman AM, Haberland ME, Edwards PA. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proc Natl Acad Sci USA. 1986;83:2704–2708. [PMC free article] [PubMed]
6. Victorov AV, et al. Composition and structure of lipopolysaccharide-human plasma low density lipoprotein complex. Biochim Biophys Acta. 1989;984:119–127. [PubMed]
7. Netea MG, et al. Bacterial lipopolysaccharide binds and stimulates cytokine producing cells before neutralization by endogenous lipoproteins can occur. Cytokine. 1998;10:766–772. [PubMed]
8. Read TE, et al. Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats. Surgery. 1995;117:62–67. [PubMed]
9. Harris HW, et al. Chylomicrons alter the fate of endotxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest. 1993;91:1028–1034. [PMC free article] [PubMed]
10. Harris HW, Grunfeld C, Feingold KR, Rapp JH. Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice. J Clin Invest. 1990;86:696–702. [PMC free article] [PubMed]
11. Jack RS, et al. Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature. 1997;389:742–745. [PubMed]
12. Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and act as a cofactor in the neutralization of LPS. J Exp Med. 1994;180:1025–1035. [PMC free article] [PubMed]
13. Grunfeld C, et al. Lipoproteins inhibit macrophage activation by lipoteichoic acid. J Lipid Res. 1999;40:245–252. [PubMed]
14. Lamping N, et al. LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria. J Clin Invest. 1998;101:2065–2071. [PMC free article] [PubMed]
15. Froon AHM, Dentener MA, Greve JWM, Ramsay G, Buurman WA. Lipopolysaccharide toxicity regulating proteins in bacteremia. J Infect Dis. 1995;171:1250–1257. [PubMed]
16. Sammalkorpi K, Valtonen V, Kerttula Y, Nikkilä E, Taskinen M-R. Changes in serum lipoprotein pattern induced by acute infections. Metabolism. 1988;37:859–865. [PubMed]
17. Alvarez C, Ramos A. Lipids, lipoproteins and apoproteins in serum during infection. Clin Chem. 1986;32:142–145. [PubMed]
18. Cabana VG, Siegel JN, Sabesin SM. Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. J Lipid Res. 1989;30:39–49. [PubMed]
19. Netea MG, et al. Low-density lipoprotein receptor deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest. 1996;97:1366–1372. [PMC free article] [PubMed]
20. Terpstra AHM, Woodward CJH, Sanchez-Muniz FJ. Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: visualization by prestaining and rapid separation of serum lipoproteins from small volumes of serum. Anal Biochem. 1981;111:149–157. [PubMed]
21. Vreugdenhil ACE, et al. Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response. J Immunol. 1999;163:2792–2798. [PubMed]
22. Kunitake ST, et al. Identification of proteins associated with apolipoprotein A-I-containing lipoproteins purified by selected-affinity immunosorption. Biochemistry. 1994;33:1988–1993. [PubMed]
23. Massamiri T, Tobias PS, Curtiss LK. Structural determinants for the interaction of lipopolysaccharide binding protein with purified high density lipoproteins: role of apolipoprotein A-I. J Lipid Res. 1997;38:516–525. [PubMed]
24. Eggesbo JB, Lyberg T, Aspelin T, Hjermann I, Kierulf P. Different binding of 125I-LPS to plasma proteins from persons with high or low HDL. Scand J Clin Lab Invest. 1996;56:533–543. [PubMed]
25. Tobias PS, Ulevitch RJ. Control of lipopolysaccharide-high density lipoprotein binding by acute phase protein(s) J Immunol. 1983;131:1913–1916. [PubMed]
26. Munford RS, Andersen JM, Dietschy JM. Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes. J Clin Invest. 1981;68:1503–1513. [PMC free article] [PubMed]
27. Munford RS, Hall CL, Dietschy JM. Binding of Salmonella typhimurium lipopolysaccharides to rat high-density lipoproteins. Infect Immun. 1981;34:835–843. [PMC free article] [PubMed]
28. Navab M, Hough GP, van Lenten BJ, Berliner JA, Fogelman AM. Low density lipoproteins transfer bacterial lipopolysaccharides across endothelial monolayers in a biologically active form. J Clin Invest. 1988;81:601–605. [PMC free article] [PubMed]
29. Schromm AB, et al. Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes. FEBS Lett. 1996;339:267–271. [PubMed]
30. Wurfel MM, Wright SD. Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers. J Immunol. 1997;158:3925–3934. [PubMed]
31. Rensen PCN, et al. Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo. J Clin Invest. 1997;99:2438–2445. [PMC free article] [PubMed]
32. De Bont N, et al. Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. J Lipid Res. 1999;40:680–685. [PubMed]
33. Auerbach BJ, Parks JS. Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency. J Biol Chem. 1989;264:10264–10270. [PubMed]
34. Jacobs D, et al. Report of the conference on low blood cholesterol: mortality associations. Circulation. 1992;86:1046–1060. [PubMed]
35. Kitchens RL, Wolfbauer G, Albers JJ, Munford RS. Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface. J Biol Chem. 1999;274:34116–34122. [PubMed]
36. Cavaillon J-M, Fitting C, Haeffner-Cavaillon N, Kirsch SJ, Warren HS. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide. Infect Immun. 1990;58:2375–2382. [PMC free article] [PubMed]
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Example of pharma framing the discussion of liver biology in a seminal liver medical textbook. The spin promotes the sales of drugs for diabetes and its comorbidities--jk. NAFLD is non-alcoholic fatty liver disease, T2D is type-2 diabetes, and T1D is diabetes mellitus.
"Insulin resistance MAY HAVE EVOLVED AS AN IJMPORTANT SURVIVAL MECHANISM TO PRESERVE protein stores in times of starvation. Under such conditions, fatty acids increased due to lipolysis. Although this increase in fatty acids resulted in reduced insulin-stimulated glucose uptake in muscle, other insulin signal pathways that regulate protein metabolism and other insulin-regulated processes could remain unaffected. In this way the body preserved circulating glucose for the central nervous system and other obligate glucose-requiring organs while preserving protein stores, both of which are essential for survival…. The intestinal microbial flora has recently been implicated in the genesis of the insulin-resistant state. Recently, plasma levels of endotoxins were shown to increase two-to three fold in response to alterations in the gut microbiota and/or a high fat diet [36,37]. This is believed to be due to a local intestinal inflammatory response to ingress of bacterial products from the lumen due to altered intestinal permeability"…. The Liver biology and Pathobiology 5th Ed, p. 722, 2009. They totally leave out reference to fructose metabolism in the liver or the effect of a high carb diet as driving fat storage in the liver—there is no fructose entry in the index, and carbs is only referred to in NAFLD as affecting the guest microflora. There is also no entry in the textbook on sucrose. This is the bible for physicians on the liver; this is what students are taught from. Thus they look in the gut and not at diet. They are thus not likely to conclude that there is a dietary cure for NAFLD, T2D, or dietary management of T1D, and view such claims or more diet fads. Not surprisingly the role of glycation in liver damage is also missed. "Excess carbohydrates and hyperinsulinemia also activate ChREBP, promoting de novo lipogenesis from carbohydrates in adipocytes. Activation of hormone-sensitive lipase and adipose tissue triglyceride lipase activate lipolysis and release of free fatty acids. This process is also promoted by activation of beta 3 adrenergic sympathetic neurons--723. At 725 "Continued activity of fatty acid transport protein 5, expressed in the liver, is required to sustain caloric uptake and fatty acid flux into the liver." "In patients with NAFLD, 60% of triglycerides stored in the liver arise from circulating fatty acids, whereas dietary fat supply and lipogenesis account for 15 and 25% respectively." 726. The remaining 125-25% of fat stored in the liver is not specified. This is upside down, for the main source of fat in the liver is the conversion of fructose to free fatty acids which are stored there in response to insulin. See Dr. Lustig on this process (Fructose is Alcohol Without the Fizz) Next the textbook blames LDL for oxidative damage this time to hepatocytes as the cause of the inflammation response with NAFLD, at 727 all this is leading to an eventual drug for NAFLD at 730. "To date no single therapy has been approved for the treatment of NAFLD" at 730. It goes on to blame higher energy intake (false) and higher saturated fatty acid "and poorer in unsaturated fatty acids, fibers, and antioxidants vitamins C and E." The plan is develop guideline for diet and exercise at 730. Also in the pipeline is the development of probiotics, since antibiotics damage the good intestinal flora. And also to develop drugs that improve the insulin signaling pathways to counter IR (I suppose they are thinking of drugs like sulfonorea). Other targets include triglyceride accumulation and nuclear receptors and transport factors at 732. On 733 there is the target of apoptosis and fibrosis.
At 258 under energy-limiting conditions, such as during a fast, the liver transiently acquires fatty acids released from stored TG in lipid droplets (LDs) by catecholamine activation of hormone-sensitive lipase (HSL) in adipose tissues. Fatty acids taken up by the liver are thio-esterfied…" Note nothing about burning excess fat in the liver.
Prof. Marcia Angell, Harvard: "We certainly are in a health care crisis, ... If we had set out to design the worst system that we could imagine, we couldn't have imagined one as bad as we have." Her excellent 77 minute lecture on pharma http://www.youtube.com/watch?v=ZqKY6Gr6D3Q


text:
Doncaster Merger
We are delighted to announce that the long established Doncaster based alcohol charity, Doncaster Alcohol Services (DAS), will be joining with Project 6 on 1st July 2020. The merger means that DAS will be part of Project 6 and operate as 'Project 6 Doncaster – formerly known as Doncaster Alcohol Services'.
As a combined organisation along with our Sheffield services, we will employ over 55 staff across West and South Yorkshire who are all committed to our core purpose of providing opportunities and choices for individuals, families and communities affected by substance misuse and complex needs, to create meaningful and sustainable change in their well-being.
DAS has worked collaboratively with the Sheffield arm of our charity (formally known as Sheffield Alcohol Support Services) for many years. In recent years both organisations have developed approaches of delivering local community based support for people in recovery from alcohol problems and going forward there will now be thriving recovery projects in Keighley (Progress), Sheffield (ARC) and Doncaster (Sober Social).
Vicki Beere, Chief Executive of Project 6, said today
"Our shared values, culture and approaches to delivering quality services that meet the needs of our local communities, will provide us with a fantastic opportunity to meet the strategic challenges currently facing small charities. The merger will ensure the charities remain sustainable during this time of reduced funding, increased competition and austerity. It will provide us with opportunities for learning and growth and the development of innovative and effective services for our local communities. Our impact on our service users and their communities will be our prime measure of success".
Callum Dixon, DAS CEO says
"DAS has a long history of delivering services in Doncaster and I'm proud that we put service users at the heart of every decision, ensuring that all organisational developments offer increased opportunities and strengthened outcomes for those who access our services. Joining Project 6 offers new opportunities to innovate our service design and delivery for the benefit of everyone accessing our support in Doncaster and also ensures sustainability going forward. This means we can continue to develop and expand local services that meet the changing needs of local people".
Doncaster Alcohol Services have been delivering services in Doncaster for almost 40 years and their vision is that every individual in Doncaster has the awareness, skills and confidence to make effective choices about their usage of alcohol and other drugs.
In 2018 a new CEO came into post, with a new vision and new direction for the organisation which now offers three strands of service delivery: prevent, treat and recover
-Prevention is all the work we do on raising awareness, supporting young people and reducing social isolation
-Treatment is the work we do supporting people to engage with mainstream treatment, providing counselling and holistic therapies through The Healing Light
-Recover is the work we do with families, the community and our work in Sober Social
https://www.doncasteralcoholservices.co.uk/
Airedale Voluntary Drug and Alcohol Agency trading as Project 6 is a registered charity number 1173006 and a company limited by guarantee and registered in England and Wales number 3430925
Core Purpose and Values
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It all comes down to an email.
swirling it around until it's soup.
You cannot show them a simple sickness.
your mental health to physical.
Because, sweetheart, it's all in your head.
And they could care less.
that would cover your whole body like constellations uncovering your destructive ideation.
or how hard it can be to lift your head or hand.
Your every thought a scuttling spider.
Explain to them this metaphor and what then?
Your resignation. Your death certificate.
Your only hope for a normal life imploded by a signature.
Kathrine Yets teaches English composition. Her works can be found in Crabfat Magazine, Blue Heron Review, and various other literary magazines. Recent winner of the Jade Ring Award from the Wisconsin Writer's Association, she now considers herself married to her poetry.


Ranch House Cafe by Gia Marie Houck - 6.750" x 10.000"
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US > Iowa > Carroll County > Maple River
Maple River (in Carroll County, IA) Populated Place Profile
Maple River: Basic Facts & Information
Maple River is a populated place located within the Township of Maple River, a minor civil division (MCD) of Carroll County.
The elevation of Maple River is 1,276 feet. Maple River appears on the Carroll West U.S. Geological Survey Map. Carroll County is in the Central Time Zone (UTC -6 hours).
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text:
Balls to the Wall es el quinto álbum de estudio de la banda alemana de heavy metal Accept, publicado en 1983 por RCA Records para el mercado europeo y al año siguiente en los Estados Unidos por el sello Portrait. Es su primer disco que llamó la atención de los mercados norteamericanos y se convirtió en uno de los más vendidos de su carrera, debido a que es el único que ha sido certificado con disco de oro en los Estados Unidos y Canadá.

Tras su lanzamiento generó algunas controversias en algunos países, principalmente por el mensaje de ciertas canciones referidas a la homosexualidad y la represión política, como también por su sugerente portada. Aun así, recibió buenas reseñas de la crítica que lo posicionan como uno de los álbumes más vendidos de su carrera.

Antecedentes
Luego que se puso a la venta generó algunas controversias en los Estados Unidos por su sugerente portada y su título, así como también por las letras de «London Leatherboys» y «Love Child», que significó que la crítica y los distribuidores de música de aquel entonces lo tildaran como un disco homoerótico y homosexual. En cierta medida, dicha controversia generó una buena publicidad en dicho país y ante ello el guitarrista Wolf Hoffmann comentó en una entrevista: «Ustedes los estadounidenses son tan susceptibles ante eso. En Europa nunca fue un gran problema... queríamos ser controvertidos, diferentes y tocar estos temas delicados, porque nos dio prensa y funcionó maravillosamente».

Al respecto, el baterista Stefan Kaufmann explicó que muchos de los temas del disco tratan sobre las minorías oprimidas en general. «London Leatherboys» trata sobre los clubes de moteros: «Son gente normal, que solo se ven diferentes y se comportan de manera distinta, pero son gente normal, otra minoría más. Y «Love Child» trata sobre los gays, es verdad, pero se trata básicamente de personas que son oprimidas». Por aquellos años el tema de la homosexualidad era prácticamente un tabú, que generaba cierta oposición en la gente y en la industria musical. En una entrevista realizada por la revista francesa Enfer a Kauffmann, sobre por qué incluir estos temas en sus canciones comentó: «Es un fenómeno que debe ser considerado. Debido a que existe en una amplia escala y debe ser desmitificado...Durante mucho tiempo estas personas han sido consideradas como enfermas o locas. Sin embargo, es el momento de respetar a estas personas, abrir nuestras mentes que a menudo están cerradas».

Recepción

Balls to the Wall marcó un antes y un después en la carrera de Accept, ya que logró muy buenas reseñas de la crítica como también una buena acogida en los mercados mundiales, superando así lo conseguido con sus anteriores producciones. Eduardo Rivadavia de Allmusic lo consideró como su disco más notorio y su mayor éxito comercial. Además, mencionó que era más melódico y menos potente que su antecesor, pero que en esencia es un álbum de heavy metal. Con respecto a su canción homónima dijo que era una obra maestra irresistible. El crítico canadiense Martin Popoff consideró que la complejidad de las letras combinadas con los riffs limpios y sobrios, le dan al disco una sutil sofisticación y un propósito singular. En una de las listas realizadas por el canadiense situó a Balls to the Wall en el primer lugar de los 100 mejores álbumes de metal de la década de 1980. Pierre Bégin de la revista en línea The Metal Crypt lo tildó de obra maestra y como un disco simplemente de heavy metal puro. Además, comentó que cuando HammerFall comenzó a grabar Renegade de 2000 con la ayuda de Michael Wagener, estaban inspirados en Balls to the Wall.

Junto con las buenas críticas que recibió por parte de la prensa, también ingresó en algunas listas musicales de ciertos países. En Alemania logró el puesto 59 de los Media Control Charts, convirtiéndose en la primera producción de la banda en entrar en una lista de su país. De igual manera, fue su primer álbum en llamar la atención de las listas musicales norteamericanas, ya que ingresó en el puesto 74 en los Estados Unidos y llegó hasta la posición 43 en la lista de álbumes de Canadá. Adicional a ello, Balls to the Wall es el único álbum de Accept que ha recibido disco de oro tanto en los Estados Unidos como en Canadá.

Lista de canciones
Todas las canciones escritas por Accept y Deaffy. Las pistas adicionales incluidas en las remasterizaciones fueron tomadas del EP en vivo Kaizoku-Ban.

Músicos
 Udo Dirkschneider: voz
 Herman Frank: guitarra eléctrica
 Wolf Hoffmann: guitarra eléctrica
 Peter Baltes: bajo
 Stefan Kaufmann: batería

Referencias

Álbumes de Accept
Álbumes de 1983
Álbumes de heavy metal
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text:
End of the Road:Clean-burning Cars Ignite Fight Within Dealers' Ranks
Posted on September 25, 2009 by aig
Man Running from Car - © Carbusters
When Monty King called around his Oregon Vehicle Dealers Association in recent months to gather opinions on Gov. Ted Kulongoski's strong-arm push for clean car rules, he found the unexpected.
The dealers weren't necessarily opposed.
"The overwhelming response was, `We like clean air, too,' " said King, who works in Salem as president of the auto group. The dealers also said, " `we don't see it's that big of a deal.' "
Though some auto dealers had furiously battled Kulongoski's plan in the Legislature and had sued the state when the governor went ahead anyway, the industry, it turns out, is not a monolith of opposition as Kulongoski's plan proceeds.
Joseph McKinney, CEO of Eugene's Oregon Roads Inc., points out the difference in opinion within his own business sector. And McKinney – admittedly a breed apart from many dealers – is enthusiastic about the governor's plan.
The governor's order will require that all cars sold in Oregon meet California's famously tough auto emissions standards the same year the Golden State's new rules take effect: 2009. They require auto- makers to cut car emissions by 25 percent and SUV and heavy truck emissions by 18 percent.
Opponents say the rules will raise the price of new cars, thus reducing sales, and many argue that the changes won't do much to reduce overall air pollution.
The state is rushing to institute the plan by late December, so the rules will be in place for the 2009 model year. If Oregon's plan advances, the Washington Legislature already decided that the northern state will follow suit, which will create what activists call a clean car corridor from Canada to Mexico.
Hoping to stop those dominoes from falling, another Oregon auto manufacturer's group and four Oregon car dealers squared off with
the state's attorneys on Nov. 7 in Marion County Circuit Court. Both sides asked for summary judgment.
Now they're all awaiting a ruling by Judge Mary Mertens James that will decide whether Kulongoski can go ahead – or, conversely, that the governor's new rules are unconstitutional.
Fault lines:
The clean car drive has proven a dicey issue for a few of Oregon's new and also used dealer associations.
The Oregon Auto Dealers Association, which represents 200 franchise new car dealers in the state, didn't join the lawsuit because doing so wouldn't have reflected the views of the organization's total membership, said Greg Remensperger, association executive vice president.
"We represent all of the dealers in the state of Oregon," he said. "The majority of them are of the same mind, but not everyone is."
The 57-year-old Oregon Independent Auto Dealers Association also has its dissenters, said McKinney, Eugene's iconoclastic dealer and an OIADA member. The organization sent out a message urging members to let the governor know that the clean cars initiative was the work of "environmental extremists," McKinney said.
"(But) it was not a message from the OIADA," McKinney said. "It was from one of the members on their board: a used car guy, a broker in Portland."
Four car dealers – from Coos Bay, Wilsonville and Portland – joined the national Alliance of Automobile Manufacturers to oppose Kulongoski's plan in court. The dealers are Coos Bay Toyota, Suburban Ford, the Don Rasmussen Company and Ron Tonkin.
Medford-based dealer Sid DeBoer, chairman and CEO of Lithia Motors Inc., did not join the lawsuit but said he doesn't support the governor's efforts. Lithia is one of the largest full-service new vehicle retailers in the United States, with 89 stores and 179 franchises in 12 states, with total revenue of $2.75 billion in 2004. DeBoer believes that the new-car requirements won't be effective in cleaning up the air, an assertion disputed by supporters of the rules.
"We've been encouraging him to support an increase in the gas tax," DeBoer said of the governor, "to encourage people to buy more economical cars and also to improve our highways in Oregon so people aren't stalled in traffic burning gas needlessly and emitting both carbon dioxide gases and polluted gases by not getting where they need to go."
"Lithia's totally for having clean air. We're an Oregon company. I was born here and raised here. But this is foolishness," he said.
None of the auto dealers based in Eugene-Springfield is on the plaintiff's list, and that's significant, McKinney said.
"Dealers are good neighbors. Dealers are not the big, bad guys up on a hill that you might think. They have to operate in their community."
Joseph McKinney of Oregon Roads Inc., based in Eugene, agrees he's not the typical auto dealer — he's an activist who sings in the Eugene Peace Choir. But he says many new and used car dealers in Oregon support the proposed emissions standards: "It's the future of the car business."
McKinney, meanwhile, has linked arms with Oregon State Public Interest Research Group activists to promote the technologies the governor's plan eventually would require.
His Eugene-based Oregon Roads Corporation does $12 million in sales a year leasing fleets of cars and trucks to businesses across the United States. Still, McKinney is not your standard auto dealer.
He's a self-described "leftist" who has campaigned for increases in the minimum wage because he believes in a "trickle up" theory. He sings in the Eugene Peace Choir. He's been arrested at the Pentagon.
But he says he's not the only dealer who supports clean cars.
"It's the future of the car business," he said. "The new car dealers I
talk to; they'd prefer clean air. They're not opposing progress."
The dealers and manufacturers bringing the lawsuit contend, however, that the clean car standards will add "thousands" of dollars to the price of a vehicle, reduce the demand for new cars and make a sizable dent in their revenues.
McKinney, on the other hand, says the evidence in the marketplace proves the reverse.
Hybrid cars are hot commodities, he said. They burn gas, but they also run on electricity part of the time, so they're cleaner. They also get upward of 50 mpg.
Chuck Gittere, fleet sales manager for the Eugene-Springfield based Kendall auto group, said he can sell "as many as Honda will let us have."
"Demand is really high," he said. "We don't have any Civic hybrids in stock. Toyota is sold out also."
Manufacturers are responding. This week, Toyota announced plans to boost production to 600,000 hybrids a year by 2008. In September, Ford said it would ramp up to produce 250,000 hybrids per year in 2010. Both are 10-fold increases.
Hybrids are in such short supply that they retain their value, McKinney said. "Right now the (Toyota) Prius has the best resale value of any car on the street," he said.
Two-year-old Prius hybrids sell for only $2,000 less than their new price. Other cars can lose upward of $10,000 of their value during the same period, McKinney said.
"Dealers profit selling hybrids," he said. "There are lists of people for these hybrid cars. People pay list price for hybrids when, on the other hand, there's a $5,000 rebate on a '05 Ford Explorer."
Front Page Article: Eugene Register-Guard, by Diane Dietz
Published: Saturday, November 19, 2005
Filed under: The End of the Road | Tagged: book, car culture, future vision |
« Car-Free Day Contest: Win FREE GAS!!!! Carfree cyclists also uses more buses and cabs »
Michael Dawson, on September 29, 2009 at 18:52 said:
There is no such thing as a "clean car." Nature operates on a dust-to-dust basis, and cars — even the "best" cars — are insane in those terms. Cars-first transportation was a capitalist pipe-dream. It is wildly unsustainable. Every day we waste giving credence to those who imply that the American arrangement has any future is a day we collaborate in planetary social collapse.
Joseph, on September 30, 2009 at 23:17 said:
I agree that the American car based transportation model is unsustainable. How Americans may transition to a more sustainable model, given the way we've built our cities and towns, is what my co-author and I address in our book.
Velove, on September 30, 2009 at 12:48 said:
"We can't solve problems by using the same kind of thinking we used when we created them."
Green cars are definitely a lie of car manufacturers to keep on making money whatever is the social and environmental costs.
At the point of time in the industrial revolution when cars were first developed, one could not fathom the negative consequences. At this time in the USA, recommending the decommissioning of roads, exponentially increasing fuel taxes and incentivizing smaller and slower village vehicles is not at all "the same kind of thinking".
Green cars are an example of hype. It's an over-promise and the manufacturers will under-deliver. But modes of transportation, including mass transit and greener cars, are less harmful. Don't we need to take steps in the right direction? How best can we transition to the sustainable society of the future?
The End of the Road is about changing Americans, not just changing cars. If our proposals were more extreme they would be dismissed.
I've been an environmentalist for over 30 years. I'm not interested in complaining and criticizing without offering a popular solution. I'm want results.
Michael Dawson, on October 1, 2009 at 18:35 said:
Joseph, your proposals are extreme, while also being accommodationist and self-serving/money-grubbing. That's why they're worse than silly. You're proposing the same scale of a political fight it would take to get truly radical, yet all for a quixotic scheme that sounds like social engineering in the bad sense.
We need urban reconstruction for rail and walking, not an attempt to squander reform energies on yet another way to use cars.
People know trains are an alternative, and that they have been suppressed. We need to talk and fight straight, not sideways.
Bart Reuven, on October 1, 2009 at 14:37 said:
And what about car-sharing?
P.S. De-carring streets and bridges is a great idea. Letting electric cars remain on "de-commissioned" streets is way different than that, though. A 1,000-pound car is as much a mortal threat to bicycle riders as an SUV.
amyigibson, on October 1, 2009 at 20:01 said:
I wonder why you see our proposals as money-grubbing; you have no evidence. I think the innovataion going on, esp among younger people, inventing new ways to transport us is amazing. We have a company in town (Arcimoto, we have no ownership or investment) doing tremendously creative work. Its sad it took this long.
As for rail and walking and biking, to me that is a great dream, but why I say I am not totally anti-cars is a bit different than Joseph's reasons. He is interested in getting there step by step, which I agree is a must. But though I am a working professional, I keep thinking that (not to be sexist) for a mom to have complete biking as main transport, even with busses and mass transit and good rail, well its a total luxury for her in most of our cities as they exist now. I think we think about it backwards; we carpool very much of the time, but how can a mother do her work and be there for her kids, take them to doctors, dentists, physical therapy (my son), and sports/arts which of course the schools no longer pay for so only those with the time and money can afford them; how can she commit to a bike all day? I would LOVE to do that, for my own health's sake, as well as being a better neighbor to all. When my life is my own again my husband and I intend to move much closer to town, into the flats, where we can live a low or no car lifestyle. A far healthier way to live, among all the other moral imperatives, and I crave it.
Joseph and I are looking at how to get from point A to point B. You can spend your energy on a total revolution and I think that;s great; we are looking at it stepwise. If every family could reduce their carbon emissions and DEBT by owning a small EV right now, well that would be 50% wouldn't it. That's a pretty big step. It is NOT the only step, nor the end. Its a beginning. And as for mortal threats to bikes; in our city (Eugene) and in Portland we have cared enough to invest big time in bike lanes. The community is constantly in dialogue and being educated about how to interact with bikes; we have lots of free classes on how bikes can drive more safely in the city, and the issue gets a huge amount of press. We do have accidents, but far fewer. And I can't agree that a "slow moving 1,000 lb. car is AS MUCH a threat to a biker as a huge SUV." You speak in very general terms. The danger is there, but where we live car drivers are very sensitive to it, and kids getting their licenses get a year or two of that blast of sensibility in their ears. Its more a way of life here. That's no consolation when someone dies of course, but its not nothing.
Evidence? Who said anything about evidence? Perhaps thou dost protest too much?
The evidence, however, does exist, now that you mention it: Joseph makes money by selling/leasing cars, doesn't he?
Meanwhile, I understand what you think and what you prefer and what your diagnosis of what's best is.
I strongly disagree with it, for reasons I've already stated.
Meanwhile, nice excuses for the extreme inherent danger of cars operating around bikes. Beautiful stuff.
We are, by the way, all for car-sharing and discuss that in the book, as you will see.
Mr. Dawson, Joseph does NOT sell any electric cars at all. He writes from an insiders perspective on the auto industry. Yes he has made money off of selliing cars but he has a rare reputation as an ethical leasing agent and dealer, well documented in our state. THAT is evidence. a) I wish that you would wait to read the rest of the book, and b) I do not see why this cannot be a civil converstion. You insist upon insults. I don't see where that gets you. We are, in our own way, on your side. No warfare needed.
You do not seem to reply on the merits of what we are saying. So far you don't trust anything we say because of Joseph's profession, not our arguments. You do not reply to my observations about our two Oregon cities working hard all the time to make it better and safer for bikes, with statistics of accidents down. If we cannot have a respectful discussion, well we are too busy at work. I genuinely thank you for your interest and hope you do wish to continue the discussion.
So, Joseph has no hopes to make money from the scheme you're both promoting in your book? That strikes me as implausible.
We're not on the same side, actually. I oppose the continued promotion of cars-first transportation. You favor its perpetuation.
You can pretend that your scheme suggests something else, but it does not.
We also disagree on how best to oppose a grave threat to both the nation and the human future. I say state what is needed and fight for it. You say take baby steps and stay silent about what's ultimately needed.
This is an old schism in social reform efforts, going all the way back to abolitionism.
Meanwhile, I will certainly read your book and may cite it as a good illustration of how monolithic our cars-first system is, how it cows even well-meaning would-be critics into essentially non-critical positions.
I wish you all the best on the personal level. I simply think you're trying to squander precious energies on a diversion. That's a political difference, not a personal one. You ought to realize that you're entering into politics here, right?
OK, enough for now Mr. Dawson. I entered political life a long time ago and you do not know how to distinguish an insult from an argument. Too bad you don't see we are on the same side. So only people who think just like you about means, regardless of sharing ends, count as on your side. I have seen so much of that in politics, way, way too much.
Nope, Joseph hopes soon to retire with an A-list company he has tried his best to run ethically. He wanted to write this book because he is not proud of the product he has been selling, has learned a lot, and is at a time in his life in which he can say it. Be cynical and think you know people's motivations if you want. That is a sad and disrespectful approach to fellow human beings.
Use our book as a case in point Mr. Dawson, of those poor folk who try to work within the system. Yup, its an old, old division. i have been on both sides. I know where I stand. I think its too bad you would waste your time trying to shoot down people (us) I still believe are your friends. There are much bigger, much more important targets than us. Why not at least start with the folks who are about to sell us regular sized regular priced (the prices we are used to selling our souls for to be cool) electric vehicles that will continue to promote the worst of globalism? Politics does not necessarily mean fighting. Enough for now, for me, with you. Thanks for the time and energy.
Amy, it seems pretty clear YOU are the one who's uncomfortable with anybody who holds a different view. You keep saying we're on the same side. I don't agree. I realize you'd like opponents of cars to sing your praises. But you're not really against cars, are you?
Nuff said, as you say.
Nope, just would prefer to have a dialogue in which a variety of opinions on how to get there from here can find some common ground. As did Andy Singer when he gladly offered to write an essay for our book. You still haven't replied on the merits, that is what I object to, just character bashing. Bye.
What merits, Amy? You want to spend reform efforts creating a massive transformation of local, state, and national transportation infrastructure, all to facilitate small electric vehicles for local commuting plus the same old big vehicles for longer trips.
That would take just as big a shift in the forces that presently prevail as the shift I propose, which is to emphasize rail and pedestrian infrastructure.
This is an either-or choice, whether you want to admit that or not. Creating your system on any meaningful scale would require precisely the same amount of political and material energy as a return to rail and pedestrian-first living would. Your plan would complete tear up existing towns, and would also require immense changes in people's personal habits.
Of course, the much more likely scenario is that your project is really just another marginal way for a few already-green folks to feel like gestures are enough, that having a mini-car is changing the world, even when it's a 1% reality.
And I've attacked nobody's character, despite your perceptions. I've pointed out that your co-author makes money selling cars and is proposing to extend, rather than end, that planet-and-person-killing business. Perhaps he won't seek to profit from your proposed plan, should anybody ever adopt it. Either way, it's objectively an suspicious reality, and something any critical reader of your book will want to ponder.
P.S. This is a dialogue of diverse opinions. Why did you assume you have the right to be perceived as a friend by those of us who really are against cars? You're not really against cars, are you?
Rights? Who said anything about rights?
Anyway, you are right, folks who are car-busters are more likely to dislike our plan than perhaps anyone. We knew that. Though we have had support from the likes of Andy Singer and Marko Thull. Not agreement, support. And I do take your point that either method will take a huge amount of energy, money, political capital. So I can see why you say its an either/or there. But I don't see it that way, I simply see it as a stepwise path to getting rid of IC cars. And I wish we could be car-free, maybe I don't understand how that is possible or likely within the time frame we need massive carbon reduction. I am interested in what we could do right NOW. Our city is spending money fixing up roads that could have been spent on Greenways. That was something that could happen right NOW and we still hope our city listens in the future. I don't want to see families left with one small ev and one large IC car. But by getting out of debt with a small ev, and the ease of plugging it in at home, we could sooner shift our "need" for one larger car that will go longer and further to a larger EV as our "other car."
You call it social engineering; we call it changing hearts and minds (no force or engineering there.) I would like to be totally against cars, but as I wrote, I do not see it happening in a world as large and complex as we have created. The "merits" I had hoped you would respond to include my point about how families (and still mothers, even working ones like me) mostly live. So no, I am not against cars. And I do worry about the carbon emission costs of making even ev's. But its kind of like the abortion issue. No one I know is really pro-abortion, any more than people are "pro-divorce." One hopes these things don't need to happen. But sometimes they do. And need or not, people WILL do them. People will not stop driving cars, I just don't see it. Our villages, as Joseph and I call them, are not old time villages with a few blocks to walk. We DO agree and seriously join you in the demand for mass transit and rail. But there is a system here, and those are not answers to everything, as bicycles are not, much as I personally wish they were.
So I tell you what I told a friend who wanted to run for governor and wanted me on his team. He had the name appeal and loyalty throughout the state, but his approach to funding would not get him there. Very pure, very admirable. But I have only one life to live, I am not a spring chicken, and I refuse to put my energy into a greater good that is, to me, an impossible goal. That said, I honestly respect all of you who are against cars period and willing to work for that. We offer an appeal we think will work, and to us its no baby step. 50% carbon reduction or elimination is not a baby step.
Actually, I am sorry for taking offense, I appreciate your continued investment in the dialogue. I am a first time published author, though a long time writer. It is hard not to defend one's baby, but I am learning, and you are helping me get less defensive.
Here's the thing, though, Amy: If people don't stop driving cars, this society and this planet is in deep, deep trouble, is it not? Indeed, nature is going to force people to stop driving cars. So, the issue is how soon we start telling ourselves the truth about that.
Opposing IC cars is not the same thing as opposing cars, as you know.
And cars are not the only source of carbon emissions, as you also know.
Personally, I think peak oil and energy use is a more immediate problem than climate change, but it's not one or the other there.
Smaller cars certainly have a role to play. But I am afraid we need to get radical sooner rather than later, and I think many people, even in the USA, already sense that.
Good luck, though! I hope you get more dialogue and readers.
"I am afraid we need to get radical sooner rather than later,"
I unfortunately completely have to agree… Very nice to read your talk. I guess I feel somehow in between. I really dislike cars, but I'm not sure about the best way to get rid of them as quick as possible. I don't believe in green cars and everything, but I would like to come back to the idea of car-sharing.
I see it as a way to make quick changes, but at the same time it is still about cars… Probably one part of the solution to allow more pro-active policies in favor of public transports and bikes…
Thanks Michael. I do hope you are not our only reader too, though you are a discerning one and I appreciate the dialogue; don't go away, and don't stop disagreeing if you must (not that you would 😉 This blog is a bit odd re readers as we are only published on it once a week, and there is plenty for CarBusters readers, who have to be pretty serious thinkers to be part of such a magazine's readers, to respond to and think about. I have uploadeed our entire blog on our own website: http://www.greenhorsepower.com, though I am not finished adding in the images. And our book will be out in hard copy within a month. So we do hope for a larger forum soon. We have not advertised our own blog yet as I am trying to finish loading it first. But I don't mind letting you and other readers know its there, and you are welcome to see it. Its not in its final, polished form yet but any day now. Who knows, maybe its our hearts and minds that will change during the dialogue.
Cars certainly aren't going to disappear overnight, barring a true collapse of the economy and/or the fuel supply. But it seems very likely to me that we are only going to get one more chance to make our urbanized order truly sustainable. I'm all in favor of using every available way of downsizing and sharing cars as we go. I simply think we can't afford to pretend that such steps are the goal in themselves. People aren't stupid, and resources are finite. We need to be honest about the state of the world, before it's too late.
Michael, Bart, I swear to you by my children's future that the steps we are proposing are not, as you say Michael, "the goal in themselves." Not at all. Not one bit. I wish for a car free life, and am old enough to be close to able to move where I can make that happen; my husband and I plan on it when we are empty nesters (but still young enough to walk, bike, and be true participants of our community.) Our book is seriously about what we see as an urgent "missing link" in our systemic thinking about how to get to that place.
So am I against cars after all? Only in my dreams. I cannot see it a practical reality for families and people who cannot afford to live or move close to their work. So we work on our city and state and national politics to make busses, carsharing, mass transit come to them. In the meantime. consider a "village vehicle." Get out of the debt that contributes to this mess and lowers quality of life, and lowers carbon emissions. But don't stop there. We have to work hard for the even bigger changes. Neither Joseph nor I have been shy of that hard, more "revolutionary" if you will, work. Joseph was in the trenches in almost every possible way as a younger man, prior to family and owning a businesss. I am currently still in them, working on state and local politics (specifically and generally, this book is only one small piece of what I do and without pay too, and as for the book, its not going to make any money!) to the detriment of my profession most of the time. But its for my kids; we are out of time to preserve it all for them. We are not rich and cannot really afford the time I put in as an activist. I would wait til my children are grown etc. and put my family's health first, but I find we can no longer wait, that is a luxury long past. In these ways, I am with you.
Small EV's are NOT the goal, not hardly. But they are the missing link no one talks about or believes in, and they won't be a viable alternative til we seriously rethink infrastructure. What pains Joseph and me is that even while we spend all this transportation stimulous money on "shovel-ready" projects, perhaps well intended, is not at all well thought out. We are wasting infrastructure money by the millions of dollars investing in a recreation of the past, only we think big ev's with lots of charging stations is a huge change. It isn't.
You can read more on our blog, http://www.greenhorsepower.wordpress.com, where the whole book is up. I am still adding the images to the second half, but you can see where we are going because the entire book is there.
I'd love to see Joseph give a TED lecture on this topic. He is amazing: articulate, passionate, and a great deal of expertise, especially in how we let the corporate and gov powers mislead us by playing hide the pennies under which cup, like the magic trick. Its all a big distraction. Hey I am not anti gov either, but a proper, healthy critic of it, even when "my own' are in power. I am waiting to see the changes I voted for, but I am sympathetic to the mess wrought by the last 8 years. Some of the choices being made right now are really disappointingto me. I am sure to you all too. Just voting is no longer an option, we are way past that. People have to fight with all they have for what they believe in.


Legal trademark protection in Latvia, Lithuania and Estonia is seeking harmonization with the Directive (EU) 2015/2436 of the European parliament and of the Council European Union of 16 December 2015. The upcoming changes will bring greater innovations, modernize the current regulations and provide a wider scope of protection. As a result, trademark owners will have new opportunities to register trademarks and develop strategies for protecting their trademarks. They can also expect more efficient administrative process.
To reflect these changes, working groups have been drafting the new provisions, amending the previous ones and intensively analyzing the Directive's impact on the exiting legislation. Even though implementation of the Directive has not met the date of transposition (14/01/2019), these revisions will be introduced into local legislations in the nearest future. The Estonian trademark law changes are planned to take effect as of 1 April 2019.
Regulations on geographical indications will remain as a part of the Latvian Trademark Law.
Rights and restrictions of the trademark owners will be elaborated.
Revocation and cancellation action cases will be decided by the Board of Appeal of Industrial Property instead of the court.


text:
Q: Variable assignment in a ksh script I am viewing a ksh script and I see a function where the variable has been defined as below. Can anyone explain what exactly the below assignment of variable means in ksh script?
temprule="\$${APPLC_NM}"

A: temprule will be assigned '$' followed by the value of the variable APPLC_NM.  So if APPLC_NM is set to "pizza", temprule will become "$pizza".
Note that temprule="\$$APPLC_NM" would do the exact same thing.  The brackets are only needed when the variable name is followed by a character that would be valid in a variable name.

A: As @Julie Pelletier indicated, this is funny syntax to make a indirect variable, or a nameref. ksh has some specialized syntax to make this work, however. This is a feature of ksh, and might not work in other shells.
The more idiomatic way to write the same in ksh would look like this:
# Set up the nameref:
nameref temprule=APPLC_NM
# Assign value to AAPLC_NM
APPLC_NM=abc
# The above two statements may be executed in any order.

# Now, temprule will contain the value of APPLC_NM:
echo $temprule
abc

Now, no funny escaping of double $ is necessary, and the result is arguably more readable.


text:
More than 20 percent of Americans regularly taking prescribed mind-altering medication
It's been just over twenty-five years since Prozac came to market, and more than twenty per cent of Americans now regularly take mind-altering drugs prescribed by their doctors. Almost as familiar as brands like Zoloft and Lexapro is the worry about what it means that the daily routine in many households, for parents and children alike, includes a dose of medications that are poorly understood and whose long-term effects on the body are unknown. Despite our ambivalence, sales of psychiatric drugs amounted to more than seventy billion dollars in 2010. They have become yet another commodity that consumers have learned to live with or even enjoy, like S.U.V.s or Cheetos.
Yet the psychiatric-drug industry is in trouble. "We are facing a crisis," the Cornell psychiatrist and New York Times contributor Richard Friedman warned last week. In the past few years, one pharmaceutical giant after another—GlaxoSmithKline, AstraZeneca, Novartis, Pfizer, Merck, Sanofi—has shrunk or shuttered its neuroscience research facilities. Clinical trials have been halted, lines of research abandoned, and the new drug pipeline has been allowed to run dry.
Syrians Join in 'Human Shield' to Protect Themselves from a US Invasion, 'Over Our Dead Bodies'
Walmart Workers Plan the Biggest Mobilization Since Black Friday
This Drug Kills Someone Every 10 Seconds, Yet It's Perfectly Legal
Create a Honeybee Haven with Native Plants and Flowering Herbs


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