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Worship teams in Kenya, Cote d'Ivoire, Burundi:
Most weeks I am in touch with Pastor Joseph via WhatsApp, so I was thrilled to hear his report on his recent trips to Kenya and Cote d'Ivoire in August. He was able to fly to both places with Esther, his wife – though one day he told me they got tested for Covid-19 four times! Both 'Fathers Heart' and 'Espoir de Vie' are teams I founded along with Joseph, so I'm naturally curious as to how they are moving forward. Both have good leadership structures in place. FH now has 34(!) young people and they have branched out into other areas of creativity; poetry, art and drama. They also recently recorded a second worship CD, called 'City on a hill'. Since 2019, EDV have become well established and are going on strongly. Most of their singers are from one church, so it would be good to see their numbers grow at some point so as to have a wider representation in Abidjan. Now they are focussed on the upcoming national elections which can be a dangerous season of time in many African nations – fear and violence is a constant threat.
Père, guéris ma nation
My voice rises to God and I cry
My voice is raised to God, He will listen to me
Father, may your kingdom come to my nation
Rise up, Ivory Coast !
For the glory of God is upon you
Father, heal my country
Father, heal my nation
Prayer : Father, our hearts long for You
Father, our souls thirst for You
We call out to You in this nation
Our nation thirsts for You
Restore this country.
For Your grace I am pleading
Come, heal my nation
How we long for You
A key way these days to reach a wider audience is through film. It's mostly how young Africans connect, either via social media of course, or on TV. It has been good to see both groups have worked on producing good quality music videos that tell a positive story of healing, reconciliation and hope for the nation. I could give you quite a few links, but here is EDV's 'Père, guéris ma nation' currently available on YouTube (english translation at left if you need)
The story in Burundi is a bit more complicated, though I am still in touch with quite a few who sang on 'Twarahawe Kumurika'. My main contact there went on to found a new church and 'Shengero Murika' is currently a part of his ministry. God is clearly blessing, and Patrick's commitment towards pastoring that church is beyond question. But I think it's also fair to say that there have been some contentious issues among those that sang on the CD, so we do need to pray that grace can flow and that a way forward can be found that can strengthen unity. Oddly enough 'Mu Bumwe' (We stand together in unity) was a key song for me on that CD; I remember it really touched my heart at the time.
'Africa Rise!'
This has already created lots of new friendships between young people from different African nations (in fact, in one case love appears to be blossoming – though naturally I can't take credit for that!) The pandemic has slowed things down a bit, but Joseph and I are still hopeful that eventually this can turn into a youth movement over time. Meanwhile, the tracks are now mixed and mastered; 10 in English (Kenya, Zimbabwe & SA), and 10 in French (Burundi, Cote d'Ivoire and DRC). We don't have CD's to sell yet, but I'd love to link you up to 2 songs in particular. 'Child soldier' is a bit unique to my mind. I can't recall any other Christian song written about children traumatized by war that speaks of bringing hope into their lives. The demo featured some jazz piano, so I tried to take it in that direction; whimsical, thoughtful, but full of hope in the end. See what you think. Can't wait for them to make the video!
'Kwetu Africa' is just my kind of SA township vibe really – love that style. And my friend Barry from Joburg played some stunning penny whistle! Obviously you know what 'hakuna matata' means – the rest is a joyful celebration of Africa as a blessing to the nations in Swahili – listen here.
Ministry footnote – is it all worth it? And how do you know anyway?
I can't remember the last time I sold a CD from the website; it hardly ever happens these days. But I did the other day. Someone in Canada; a Rwandan who moved there some years ago perhaps. They wanted to buy a 'Rabagirana Rwanda' CD; funnily enough I had just re-pressed a few as we had sold out a long time ago. After sending it, I got an interesting email reply which forms the backstory to this bit. RR was a long time ago now; think it got released in 2003. At the time I do remember asking myself whether it was worth doing. Lots of time, money, organising and teamwork. The thing is, you never really know if the songs are going to have a wider impact in the nation. They might, but chances are we probably won't hear about it anyway. At the end of the day it is a step of faith; you do have to trust that God put it on your heart and that He'll find a way to make it bear lasting fruit, don't you? In the end I've always said to myself that the young people involved will have a life changing experience in making and singing music and perhaps going deeper in their faith – surely that's worth it anyway even if nothing else happens? And it is, of course.
Greetings Dave!
Good to hear from you. I'm so glad I found the CD! I grew up listening to it in Rwanda around 2005. I remember Uwimana Aime being part of two of the songs in the album. And he's one of my favourite artists in Rwanda. I still find myself singing the songs and I wanted to have a physical copy to listen to.
I can't wait for it to arrive! Thank you for reaching out.
Jeremie (with permission)
I do actually know for a fact that very many of those Rwandan children grew up with deep and lasting memories of being involved with RR, and for some it has shaped their world view as young adults – now they are also writing songs and leading worship in their churches. That's so humbling. But just maybe (in my dreams) the impact went wider? Now you know why I found Jeremie's reply so encouraging.
Personal footnote… pray for new opportunities!
I won't embarrass you by mentioning my age, but the years tick by, don't they? The truth is, I feel very well and healthy and still dreaming dreams about what I could do in the future. Leading worship and working in the studio still excites me. Mixing song arrangements I've worked on is a joy these days with all the amazing new music tech software that's available. I now own software emulations of most of the bits of hardware kit that I could only dream of owning in the 80's and 90's! (original Fairchild 660/670 or TLA hardware compressor anyone?…that will cost £thousands!) These days the software versions are cheap as chips by comparison, but absolutely top class and accurate – made by sound engineer nerds who really care about these things.
I normally end with a 'Diary Dates' box but since no African mission trips are going to be possible this year, I've decided to leave it. Thanks for all your amazing support and prayers. Do stay safe and take care!
Love from Dave & Jean
With special thanks to The Crossroads Trust.
The Crossroads Trust is a Registered Charitable Trust, set up in 1987 with the following aims: to assist in the encouragement of missionary activity designed to foster the spread of the Christian faith; to promote better education between and within diverse cultural settings, and to provide relief for the poor and needy in society. Since 2005, the Trust has focussed solely on supporting the reconciliation ministry of Dave Bankhead and 'We are One!' Trustees include; John Jenkins (Chairman) and Simon Shaw. Registered Charitable Trust No: XN74834
© Copyright We Are One! All Rights Reserved.


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The Blue Mountains is home to a vibrant and diverse community spread across more than 100 km from Lapstone to Lithgow.
A set of fact sheets developed through the Blue Mountains Community Interagency with information specific to the Blue Mountains community on Ageing, Children and Families, Disability, Environmental Sustainability, Financial Stress, Homelessness and Housing, Inclusiveness, Indigenous People, Transport, Wellbeing and Youth is available on our Facts about the Blue Mountains webpage.
The Blue Mountains Community Services Directory along with other service-related directories are available on our Accessing Services webpage. The Blue Mountains Community Services Directory provides the names and contact phone numbers for more than 300 community and government organisations providing services to people residing in the Blue Mountains.
Information on MCRN member organisations and the services they provide is available through the individual member websites.
A range of support services are available to assist people affected by bushfires and other emergencies. These services are listed on our Bushfire & Emergency Recovery webpage.
BM Community Interagency
MCRN Member Portal
How to join MCRN
Resources for Emergencies
Service Directories
Facts about the Blue Mountains Community
A set of issuebased fact sheets has been developed through the Blue Mountains Community Interagency with information specific to the Blue Mountains community on Addictions, Ageing, Children and Families, Disability, Environmental Sustainability, Financial Stress, Homelessness and Housing, Inclusiveness, Indigenous People, Transport, Wellbeing and Youth is available on our Blue Mountains Community Issues Fact Sheets webpage.
The Blue Mountains Community Services Directory along with other service-related directories will shortly be available available on our Accessing Services webpage. The Blue Mountains Community Services Directory provides the names and contact phone numbers for more than 300 community and government organisations providing services to people residing in the Blue Mountains.
Information on MCRN Member organisations and the services they provide is available through the individual Member Websites which are listed under the 'Our Sector' menu item.
Emergency Recovery & Preparedness
A range of support services are available to assist people affected by bushfires and other emergencies.
Resources for the Community to help prepare for an emergency, during an emergency and with recovery are available from Emergency Resources for the Community. This page also includes information on resources for businesses and for Community Service Organisations.

redpajama_set_name: RedPajamaCommonCrawl


The utilization of functional nanoparticles for biosensing has generated a great deal of interest because they are found to greatly enhance sensitivity of various given methods. Electrochemical biosensors based on nanoparticle labels are very attractive for bioassays, due to their high sensitivity, inherent simplicity, miniaturization, and low cost. In this presentation, we will give an overview on recent development of nanoparticles based biosensors for selective and sensitive detection of protein biomarkers.
Infectious and chronic diseases and bioterrorism are of tremendous global concern. The National Research Council of Canada is dedicated to developing nanoparticle platforms to aid in the rapid detection of these deadly diseases and security threats. Specifically, this presentation will highlight our efforts to utilize unique surface ligands anchored to magnetic nanoparticles, dye-doped silica nanoparticles and quantum dots to enable the selective labeling, magnetic confinement and optical detection of a variety of potentially harmful bacteria and cells in biological samples.
We describe a new concept using combinatorial self-assembly of DNA nanotiles into micrometer-sized two-dimensional arrays that carry nucleic acid probes and barcoded fluorescent dyes to achieve multiplexed detection. The specificity and sensitivity of the arrays by detecting multiple DNA sequences and aptamer binding molecules were demonstrated. Accurate control of the interprobe distances and solution-based binding reactions ensures fast target binding kinetics. The detection sensitivity can be future improved using hybridization chain reaction (HCR) as a signal amplifier.
Dalibor Hodko, PhD, Director, Advanced Technology, Nanogen, Inc.
Principles and examples of electronic microarray applications for electric-field assisted (nano-)assembly of molecules and components for sensors and detection of pathogens will be summarized. Electric field and hydrodinamically enhanced biochemical reactions will be demonstrated in the array format such as rolling circle amplification for isothermal on-chip amplification with sensitivity approaching few molecules. Attempts toward miniaturization of the electronic microarray platform will be summarized with intended point-of-care applications.
Staphylococcal enterotoxins (SEs) are amajor cause of food-borne diseases. Traditionally, SEs assayed immunologically with ELISA. Carbon nanotubes' (CNT) uniquemechanical and electronic properties combined with a large specific surface areamake them attractive for biosensing.We applied CNT to increase the sensitivity of a simple and portable point-of-care immunosensor based on the detection of Enhanced chemiluminescence (ECL) by a cooled Charge- Coupled Device (CCD) detector. This combination of ECL, CNT and CCD technologies is used to improve the detection of Staphylococcal Enterotoxin B (SEB) in food. Anti-SEB primary antibodies were immobilized onto the CNT surface and the antibody-nanotube mixture was immobilized onto a polycarbonate surface. SEB was then detected by a sandwich-type ELISA assay on the CNTpolycarbonate surface with an ECL assay. SEB in buffer, soymilk, apple juice, andmeat baby food was assayed with a limit of SEB with CCD detector is 0.01 ng/mL similar to the detection limit of a fluorometric detector, which is farmore sensitive than the conventional ELISA detection limit of ~1 ng/ml. Our simple, versatile and inexpensive CCD based Point-of-care detector combined with the CNT-ECL immunosensormethod can be used to simplify and increase sensitivity formany other types of diagnostics and detection assays.
Michael D. Berg, PhD, Chief Scientific Officer, Attometrics, Inc.
We report the construction of a novel biosensing nanodevice to detect single molecules of target DNA, RNA, or protein on the same platform at the same time. The combination of reliable specificity, high sensitivity, and low cost should make this technology a viable option for widespread clinical use. Early diagnosis of diseases such as cancer can have a profound impact on a patient's prognosis. The diagnoses are dependent on rapid, sensitive detection of specific protein and/or nucleic acid biomarkers. Rapid, sensitive detection and identification of pathogens is also critically important to minimize the transfer and spread of disease as well as to devise and evaluate effective treatment strategies.
Oligonucleotide probes that are used to amplify target gene sequences are nanoscale information transducers. A single 25-nucleotide probe (8 nm length) represents extraordinary sequence specificity, as only one of 1015 different sequences of the four bases A, G, C and T. Such probes are noisy channels, due to idiosyncratic interactions of similar gene sequences from distinct organisms as well as specific mutations within a species. This accounts for unacceptably high rates of false negative and false positive results from PCR-based tests in critical applications. Claude Shannon and Edward Moore demonstrated that reliable (error-free) communications circuits result from networks comprised of less reliable ("crummy") components or relays. This principle underlies the superior sensitivity, specificity and multiplicity of the TessArray Resequencing Pathogen Microarray (RPM) for simultaneous detection and identification many different viruses and bacteria in a single specimen. An RPM detector array network of almost one million different oligonucleotide probes detects and specifies almost 125,000 bases of virtually error-free pathogen gene nucleotide sequences. A real-world TessArray RPM application example illustrates rapid and unequivocally accurate detection and identification of any HN subtype of human and/or avian influenza virus.
Avian influenza virus (AIV) and Foot-and-Mouth Disease virus (FMDV) outbreaks can result in severe economic losses. We developed two electronic microarrays that can subtype all 16 H (hemagglutinin) subtypes of AIV, and all 7 serotypes of FMDV. Probes were also designed against the conserved regions of the AIV matrix (M) gene and FMDV polymerase coding region to detect all AIV and FMDV, respectively. Thirty-two influenza isolates representing all 16 H subtypes, and 23 FMDV isolates representing all 7 serotypes were correctly identified and typed using the two arrays.
Abstract not available at time of printing. Please visit www.KnowledgeFoundation.com for the latest Program updates.
Chemical detection equipment is becoming more and more sensitive as the particles are smaller, yet not all chemical sampling equipment is in this range yet. Nano sized particles have different properties than the regular chemicals. There are already studies finding carbon nanotubes have asbestos like qualities and the bioaccumulative effects found in fish brains. Come discuss nanotoxicology, how the industry is changing. Resources on PPE, which MSDS chemical databases track at this level, and a survey of field sampling equipment that work on the nano scale. The Nano Safety Consortium is working with the EPA to have companies voluntarily come forward with safety data.
Industry and academic scientists are encouraged to submit poster titles for this event. One-page abstracts (8 1/2" x 11" with 1-inch margins) must be submitted via e-mail submit@knowledgefoundation.com no later than October 20, 2008 for inclusion in conference documentation. Additional poster submissions will be accepted until November 5, 2008 but may not be included in conference documentation.
Registration fee includes lunch on the first day of the Main Conference, refreshments, access to posters and exhibit, and all documentation made available to us by speakers.
Exhibiting/Sponsoring Please contact Lindsay Kennedy at (617) 232-7400 ext. 210 or email lkennedy@knowledgefoundation.com for all inquiries.
A block of rooms has been allocated at a special reduced rate. Please make your reservations by October 14, 2008 to obtain this rate. When making reservations, please refer to The Knowledge Foundation. Contact The Knowledge Foundation if you require assistance.


As a highly-respected and experienced dentist in the Scottsdale-Phoenix area, Dr. Todd Mabry has been featured in several media publications and news outlets over the years for his commitment to exceptional patient care and quality results. Below is a compilation of videos in which Dr. Mabry is called upon to share his dental knowledge and expertise, as well as to highlight and showcase some of his unique patient cases. Please feel free to click on any of the segments to view the individual media appearances of our cosmetic dentist.


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This Groundbreaking Biotech Technology Is Revolutionizing Cannabis And Beyond – with Cameron Keluche of KelSie Biotech and SUM Microdose
Incredible biotech developments are starting to bring new and exciting products to the cannabis market that would have seemed like science fiction just a few years ago.
Here to tell us about it is Cameron Keluche, founder and CEO of sublingual cannabis tablet company SUM Microdose and president and CEO of KelSie Biotech, an innovation and intellectual property holding company in Boulder, CO.
In this episode, Cameron shares with us a breakdown of KelSie's "Bubble Drying" technology and how it's quickly revolutionizing both the pharmaceutical and cannabis industries.
Learn more at https://www.kel-sie.com and https://www.summicrodose.com
Cameron Keluche's personal background and journey in the cannabis space
An inside look at KelSie Biotech and SUM Microdose and their mission to bring cannabis into the pharmaceutical market
How KelSie Biotech is applying Bubble Drying – the same technology used to create a dry measles vaccine – to formulate the world's most stable cannabis powder
Ways in which KelSie Biotech's dry cannabis powder can be used as an inhalant for optimal bioavailability
An explanation of "excipients" and how they help the body pull in cannabinoids more effectively than oil constituents
Ways in which inhalants are superior to other cannabis delivery methods
How SUM Microdose uses KelSie Biotech's Bubble Drying technology to create sublingual cannabis tablets designed for different purposes including mood and sleep
Ways in which KelSie and SUM are bridging the gap between the pharmaceutical biotech and cannabis spaces and Cameron's goals for the years ahead
Matthew: Hi, I'm Matthew Kind. Every Monday, I look for a fresh new episode where I'll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at cannainsider.com. That's C-A-N-N-A insider.com. Now, here's your program.
Today, we're going to talk with Cameron Keluche, about the biotech advances in cannabis. Three things you'll learn in this interview is one, why vaping as it stands today may be replaced by a better biotech solution. Two, why it pays to play the long game when conceiving your cannabis company. And three, how intellectual properties becoming a larger part of many cannabis related businesses. I hope you enjoy this interview.
Incredible biotech developments are happening in cannabis that promise to bring new and exciting products to market that would have seemed like science fiction just a few years ago. Here to tell us about it is Cameron Keluche of KelSie Biotech, and Sum Microdose. Cameron, welcome to Canna Insider.
Cameron: Thank you, Matthew. Thank you for having me this morning.
Matthew: Give us a sense of geography. Where are you in the world today?
Cameron: I'm in Denver, Colorado and about to head up to our labs in Boulder.
Matthew: Okay. And tell us a bit about KelSie. What is KelSie at a high level?
Cameron: So KelSie Biotech is actually an innovation and IP holding company that is not plant touching. We effectively continue to progress on a lot of work that was preceded essentially the creation of KelSie and different pharmaceutical arenas and have decided to apply that technology in a licensing model in the cannabis arena.
Matthew: Okay. Can you share a little bit about your background and journey and how you came to get involved in the cannabis space and specifically in KelSie Biotech?
Cameron: Absolutely. So I have my undergraduate from the University of Denver here in Denver, Colorado, in cognitive neuroscience, and I specifically focused on psychopharmacology. So that's basically the interface of let's say drugs and the underlaying biological components of the brain. So I kind of always had an interest essentially in this side of things, but then shortly thereafter, I was whisked away to North Dakota during the oil buck and boom, assisted one of the Native American tribes up there with building a management information system to help monitor the production of oil. So tracking on highly-priced, highly-regulated commodity.
So when the downturn essentially occurred up there with the oil market, we decided to try and bring that platform back here to Colorado and exchange, let's say barrels of oil for essentially pounds of marijuana. The award had already been given to Friendwell for metric. So we kind of decided to pivot at that point in time to really do at data analytics on the back end, and kind of trying to work with them as to help with a lot of, let's say, machine learning in that capacity. So I kind of have a software background in that facet, and then slowly, actually was introduced to Dr. Robert Sievers, who is on faculty at university Colorado Boulder who was doing some research on just the industrial hemp side.
Since we are in Colorado, he was able to do some hands on research there, but was also interested in looking at hands off components. And the remainder of the cannabis plant almost in a longitudinal study fashion. So we started trying to look at how could we could actually empower, help them with tools so they could get a little bit better data analytics on what they were actually observing from different people that were trying to participate as they could not actually prescribe, or in fact, essentially dictate any sort of usage regiment. And then through that, and through discussions with Dr. Sievers learned of essentially a technology that he had developed previously that we thought would be a great addition to the cannabis industry, really got into some discussions decided to team up with him and his daughter, Christy Spencer Sievers, who is the vice president of KelSie Biotech, and that's actually where KelSie was kind of conceived. So KelSie is K-E-L, the last person three letters of my last name is S-I-E. So KelSie, so Keluche Sievers, is how that came into existence, and we really kind of almost merged two kind of entities into a new one, to specifically address this new exciting field of cannabis research.
Matthew: Okay. So you initially were funded or had some funding from the Bill and Melinda Gates Foundation for a dry measles vaccine. Can you talk a little bit about that, and where do you see possible applications there for cannabis as well?
Cameron: Absolutely. So as I kind of mentioned, Dr. Sievers had some pre-existing technology, which was, as you just mentioned, it was a $20 million five-year-grant from the Bill and Melinda Gates Foundation, that was through FNIH, so Foundations for National Institute of Health. And they did everything from preclinical all through clinical trials actually in India, 60, I believe, adult male participants for safety and everything like that plus pass with flying colors, no adverse reactions. But what we decided to do is very similar to the vaccine, so I just want to be...sorry, just to clarify real quick, so that grant was actually given to Dr. Sievers prior to the formation of KelSie and then that was kind of the genesis for the IP that we've carried forward and continue to innovate upon.
And so in that same facet, the interesting thing, when you actually look at taking, let's say something like a vaccination, we have to have a live attenuated vaccine, you have a very delicate what's called an API, so Active Pharmaceutical Ingredient. It's very similar to that in cannabis, where you don't wanna have high temperatures to essentially degrade or change that form factor. So what we effectively did was we both have patents pending, patents that have been issued and a number of different gimmicks, an IP, R&D innovation component surrounding to protect that technology and actually the delivery of cannabinoids and let's say the formation of cannabinoids through that process.
Matthew: Okay, so let's just break this down a little bit. So the measles vaccine is kind of like a dry powder that you could inhale, that's easier in third world countries where there may be refrigeration challenges and other challenges and it's more stable. And now, you're looking at ways where you can transfer that kind of inhalant powder and other form factors into the cannabis world. Is that right?
Cameron: That is absolutely correct. Yeah. So as far as stabilizing anything, it's actually much more stable essentially in a dry component and so you're absolutely correct. So what we really were looking at doing is taking cannabis just as another active pharmaceutical ingredient and cannabinoids, sorry, actually breaking out of its core constituents and then rebuilding and then actually stabilizing those is really where we started our let's say cannabis journey.
Matthew: Okay. And one of the words I hear thrown around a little bit is excipients. Can you just tell us what that is before we go forward in case you use that word so much so people know what it means.
Cameron: Absolutely because without fail well, so it's actually it's an inactive substance that's actually either like a services like either let's say a vehicle bulking agent, medium of some kind, to actually help with the transport and delivery of the active. So think of it as kind of the inactive components of what you're actually taking in. For instance, like let's say with Advil, it's not all Advil, there's a lot of different things in there that actually helping get that actually into your system.
Matthew: Okay. And talk about how particle can be small enough to bypass the lungs coughing reflex and why that's important in terms of cannabis delivery.
Cameron: Absolutely. So it's kind of like threading a needle when you're trying to do deep lung inhalation. That's usually about a three to five micron range. So I mean, everybody's always heard it, but it's a nanoencapsulation, nanoparticles especially it's been a big buzzword in the cannabis industry recently, which is actually not ideal for deep lung delivery just because they are too small and they seem to a glom rate and don't actually get delivered to the target site. So one of the things that we're able to do very specifically is actually formulate and essentially processed through our proprietary equipment, different targeted ranges, be it at the nano level through different micron ranges, specifically with response to cannabinoids, keeping them the three to five micron range and having certain, and here's another term for you, particle morphology.
So that's basically the aerodynamics of the particle to be able to actually get into the lung to help...the body actually is pulling that in rather than combating because as effectively as you know what to do, let's say, the lungs are not designed to absorb oil. So we try and use again, excipients that the body is more welcoming to then an oil constituent to actually pull in the cannabinoids rather than having some sort of like a combative element on the lung surface.
Matthew: Interesting. And it really is a lot of potential because everybody thinks to the gag reflex, but if it's so small that there is no kind of gag reflex when you're inhaling then it really opens up a lot of different windows here. I mean, I'm even thinking like you could spray
Vitamin D for people that can't seem to get it any other way, or they could get it to their body perhaps that way or there's tons of different ideas that come to mind when you think about being able to get a desired outcome through inhaling.
Cameron: There absolutely is. And that's one thing that we continue to, again, from KelSie Biotech standpoint, we continue to get different RPs either from the Department of Defense, different various things to look at a different delivery mechanisms for other actives. But we've really decided to kind of keep our heads down focused on cannabis during this window. But again, you're absolutely right, the technology is very broad and applicable in multiple different fields abuse.
Matthew: So we talked a little bit why inhalants are superior, they're more stable, they don't need refrigeration. Is there any other ways you consider them superior to other adult delivery mechanisms?
Cameron: Yeah, absolutely. Well, the interesting thing is actually, so just real quick, just because I use the term bubble drying is kind of what we call our specific technology. We're actually able to take so for instance, let's say we're trying to administer CBD to the lungs, and you were to grind it up really, really fine and say, Oh, I have a great fine white powder that looks very similar to KelSie's, you still as CBD being a crystalline structure, you've now just created smaller crystals. So through our process, which again, obviously, you don't really want to inhale a bunch of crystals into your lungs. So through our process, what we actually do is gain through the excipients, formulation, everything of that nature, we're actually able to take CBD without changing its chemical structures and actually make renderer at a more surface so that it is no longer a crystal and so it's actually more welcoming and less damaging to some of these delivery surfaces.
So like I said, there's other kind of...people say the devil's in the details, it's really I'd say the magic is in the details with a lot of the stuff that we're kind of actually trying to explore with because, you know, with the broad let's say ranging effects either be subjective or empirical that have come to light around the cannabis use in different kind of capacities. Be it through, you know, tinctures vaping anything of that nature, we're really just trying to keep our minds very open and trying to make sure that we have flexible, applicable technology to try and assist in trying to maybe take these to a more pharmaceuticals knock on wood level when that actually becomes a more, more efficacious way to deliver.
Matthew: Okay. And so, I mean, people are really into vaping. Like it's really been a product market fit and taken off in a massive way. What's kind of the pathway where people would start to transition to more like inhalants that are less damaging in your view? What's kind of the first step in doing that?
Cameron: Right, right. And so it's really got to kind of be more towards a tailored formulation model. We're not trying to replace vaping or anything like that, because of course, people will always, you know, have their, let's say, strain or essentially formulation that they like on that side, that's more of just a, let's say it's more of a recreational kind of component, even if it is being used for medical use. Really what we're focusing as essentially as tailored specific formulations for delivery. Again, with the bubble drying technology, we're able to keep the acidic form. So THCAs, we actually can still introduce that because generally with combustion, obviously that's the reason you're actually combusting the substance is you want it to turn to the THC to get that kind of psychotropic or let's, before we a feeling that's associated.
But we're actually able to keep a lot of those acidic forms in there as well as not degrade through formulation. So we're able to kind of go back and build from scratch tailored formulations as it becomes more pharmaceutical. So sorry to circle back to answer your question. It's really going to be as we see more evidence coming forth for different specific, let's say formulations for specific conditions, or ailments, or anything like that, that's really where we're kind of staying waiting in the wings to really watch that landscape and figure out how we can actually apply it been even third party formulations through our delivery technology and kind of really partner in that capacity. We're not trying to invent the wheel on the formulation front to try and beat the large pharmaceutical race. We're really more of a delivery platform more so than anything else.
Matthew: Okay, so that's kind of the PCC in the value chain for KelSie. You're taking pharmaceutical ingredients, but also techniques with ingredients, you're stabilizing them, making them more bioavailable, and kind of helping other companies and consumers get kind of the benefit that pharmaceutical customers get in the cannabis space.
Cameron: Correct. Yep, that is the ultimate goal. Again, right now, we're obviously very careful to make sure we're not making any claims or anything of that nature, but are trying to make sure that we're staying true to our kind of core values, for instance, everything that we use, I'll get on that excipients list on the FDAs, you know, grass list which is generally recognized as safe we are still trying to essentially stay as close to our core roots really in that science foundation, while participating in this very exciting new market.
Matthew: Is dosing more precise with inhalants versus liquids? And if so why and how?
Cameron: It generally is. So this has nothing with respect to specifically to cannabinoids, but the surface of your lungs about the size of I believe half of a tennis court. So as far as what actually is, you know, it's exposed to the outside world that is by far the largest surface. When you're able to actually deliver something to the deep lung, it has a very close absorption rate to almost intravenous application. So IV injection, so we'll put it this way, as like if you know let's say the doses that you're administering at know what the uptake is you're able to actually use a substantially less dose and still get the same blood quantum or the same quantity into the blood. But you're also able to like narrow that window of essentially variability that you may have with tinctures that obviously go through the digestive tract, everything like that and then it goes through called first pass degradation. So they go through the liver, and you're not only getting like a metabolite of the cannabinoid, another cannabinoid itself into your system. So there's a lot of variability that essentially guesswork that's kind of taken out by able to get that direct administration into the bloodstream.
Matthew: Okay, that makes sense. Now, let's turn to what you're doing with SUM. Can you give us a high level overview of what that is and why you started it?
Cameron: Absolutely. So SUM actually is an acronym for superior uptake microdose. So again, as I was just kind of mentioning, being able to actually deliver a less quantity but still get some, let's say, the benefits of it. What we specifically did as we actually have the patents around taking our same bubble dried technology that we would normally use for the inhalants and then putting that into a compressed sublingual wafer. So really what we've done there is we've taken, let's say, the benefits of the lung delivery but taken out the guesswork and everything and let's add the complexity of educating somebody on actually dry powder inhalation.
So the SUM product line effectively is a bunch of microdose tablets so rather than let's say putting 10 in a pack, we put 40 in a pack you still have like for the majority of our products you still get you know hundred let's say milligrams of THC per, so it is a THC containing product so it's just available currently here in Colorado, but we're quickly expanding our footprint. With the SUM specifically, what we've done is instead of the excipients being designed to help targeted at helping the lungs absorb, we've actually helped them with mukul adhesion. So when it's under the tongue, it actually helps hold the cannabinoids in place so that you can actually absorb them through that rich capillary bed that's under your tongue to also essentially get that into your bloodstream before it goes through any sort of first pass degradation through this, you know, stomach, liver, everything of that nature.
Matthew: Okay, that makes sense. And you have different versions of SUM like focus, calm, sleep, how do you make a specific mood or motion like this, how does that work?
Cameron: That's a great question. So what we actually did is went back and reviewed a large body of research to kind of try and look at what the balance are both let's say just the physiological response of low doses of THC, low doses of CBD. And then we actually went in and did some very fairly large sample audiences before we landed on these formulations as you know, we can't make any structure function claims or anything or essentially any claims really of that matter about these, but it's kind of guiding at least the let's say the even that the novice into trying to identify which of these modes that they would actually kind of aligned with better for their for their use. Really what we decided to go with was almost attacking the market if you will, from very good say almost needs based and then formulating for those need base for the initial four skews, the one that we don't I think have on here is energy instead of sleep. So sleep is out actually been brought to market yet it will be CB in containing, it will be out here fairly shortly. We're still doing final formulation on that. But with the first four, so that would be was that energy, focus, calm, and relief, we're really targeting different kind of user group experiences that people were actually striving for and then formulated for those. It was almost a reverse engineering and then we went back and looked at the literature to help support the final formulation.
Matthew: Now, what's going on in the KelSie office? Are people experimenting with these for firsthand use?
Cameron: Not in the office. But yeah, so we actually do have some focus groups and everything like that, that our CRO, then actually conducts, that we actually go back and redo reformulation, looking at number of different age groups, again, demographics, everything like that. He also has a degree in cognitive neuroscience, split the differences in statistics. So we actually are able to throw some pretty sophisticated statistical models that are looking at how we break down a lot of these different elements and then also use that information to kind of garner what our next ground of essentially, let's say improvements on our existing formulations as well as new product development. So he kind of steers that ship.
Matthew: Okay. And to talk about water solubility a little bit, I mean, that seems to be a big market if we can figure that out and how it works and how to develop products there with cannabinoids. Can you talk about that a little bit with SUMs?
Cameron: Absolutely. So water solubility is also a tricky thing that I think the term keeps getting misused quite regularly in the cannabis industry is everybody says they have a water soluble as they're near water soluble, but to date, we've not found a true water soluble element just because you have...just because cannabinoids in general are so what's called lipophilics, they wanna stay on oil solution, but that makes them hydrophobic, so they're scared of water effectively. A lot of people using emulsifiers and different things to keep them in suspension, or even in a true solution. But the water soluble thing is gonna be an interesting thing to try and crack.
The way that we've try to essentially address that with respect to the SUM product line is, again, through the excipients keep the cannabinoids spread out so that they don't clump together because they do like to clump back together. Keep them spread out, but then also I said like adhere them to the membrane so they actually have enough time to actually cross the barrier into the bloodstream. So we do everything we can from essentially a particle size and morphology, we then couple that again with the formulation from the excipients side to make sure that we're able to optimize the delivery for whatever the target site is. And in the case of SUM, that would be sublingual with the inhalants eventually that obviously the lungs which different formulations, but the principle is effectively the same is to use the lowest amount and get the highest yield enter the bloodstream.
Matthew: Okay. And tell us a little bit about KelSie and SUM. Where are you in the fundraising process?
Cameron: So SUM is a registered or is the trademarking process right now. It's wholly owned by KelSie Biotech. So it's very important for us to be able to with the, let's say, unique nature of microdosing and the unique nature of what we're really bringing to it to be able to control the messaging and the educational component. So what we elected to do at KelSie as part of kind of our licensing model was to also develop a product line that was a full kind of turnkey solution where we would actually supply the marketing material and the educational component be it for the bar tender, the purchasing manager everything all the way through. So we're able to keep that kind of cohesive experience if a consumer was to purchase here, you know, purchase here legally in Colorado and then one of our licenses, let's say in California, we're able to go purchase there and it's the exact same product. So we've done a lot from essentially a homogenization standpoint to make sure that those products would be identical.
Now, with respect to essentially where we are in the fundraising process is into KelSie Biotech right now, we are actually anticipating closing our series A round by the end of the month. We have some very strong players in the industry that have kind of stepped forward that we're working with that I unfortunately can't name right now. But that is we're effectively closing that series A round here, you know, hopefully in the next week or so.
Matthew: Okay. Well, you've got a lot of interesting stuff going on here, Cameron. This is really at the front edge of biotech pharmaceutical and cannabis, what kind of gets you most excited about this space?
Cameron: I think really the exactly what you just mentioned is one thing that we're definitely turning our majority of actually of our attention to now that we've kind of cleaned up and strengthened our patent suite is really exploring minor cannabinoids. So really starting to look at minor cannabinoids in different quantities that, you know, everybody's kind of heard about the, you know, they've been kind of let's say, you know, whispered about in different various threads be it from [inaudible [00:22:48], what have you, but really to actually get that down to as much of an empirical bottle as we can with addressing those and see how they actually interact with the other cannabinoids and other quantities.
So it's really going to be a true science push kind of on our side to make sure that we have a, again, a good strong library of information to draw from because we kind of, as you mentioned, really at the forefront, we've gotten about as far as, let's say, other peer reviewed articles, be it from Israel, Europe, you know, because they've been leading the charge there. We've kind of gotten to the edge of what we're able to glean from others, and so now we've really decided to internalize and really attack this miners market and minor cannabinoids. You know, more and more internally, they're relying on external, either validation or advocacy from other people's peer reviewed work.
Matthew: Okay. Cameron, I'd like to ask a few personal development questions to help the audience kind of get a better sense of who you are as a person, perhaps outside of work. Is there a book that's had a big impact on your life or way of thinking that you'd like to share?
Cameron: It's actually super interesting you should ask that. Oddly enough, as I was like growing up I was actually diagnosed with a learning disability. That kind of actually related very strongly to reading. So I actually really, let's say you kind of faked my way through a lot of school where there's a lot of, let's say, reading elements and would really kind of in through that kind of developed other compensatory mecha...or so effectively other ways to work around it either through listening very intently, everything like that. So it's actually kind of it was interesting. So I have a very good short term memory, which I can directly probably a credit to that. But as far as I would say, a definite book, I would say that would actually is very difficult, again, because like I said, it was just really more actually an amalgamation. Being Native American, I was always having an oral culture. I was always around a large...through my father and through essentially a lot of our family connections. It was really more, again, almost like it's like a fable and oral storytelling element that kind of, I'd say really had the largest impact on my life. So it was kind of I guess, antiquated in that sense, but was I think gave me an interesting lens, an interesting tool set to kind of approach the world with.
Matthew: Okay, any other interesting kind of contrast from Native American life to, you know, non-native American life that you'd like to share?
Cameron: It's really been that holistic healing element, I would have to say that. So again, just kind of some background. So my mother actually has her PhD in mythology in depth psychology. So we also have it from that side. She's not native, but definitely has done mountains of work effectively in that arena. And so it was kind of an interesting, I'd say, dichotomy being able to run around in this kind of, it's Anglo society where it's very Western medicine, growing again, with the cognitive neuroscience, looking at brain biology, looking at interactions of specific chemicals, but then also having that kind of holistic healing element here from my youth or from, you know, just family interactions. So I think it's really helped when cannabis essentially came up, that was one of the things that we were most excited about because it really does have this whole holistic element to it, they're able to explore in this pharmaceutical lens or either vice versa, however you actually want to really think about that. But there is I think this is the first time in the United States, or either in western medicine in recent history that we've seen some sort of a marriage of a true holistic, you know, let's say, plants derived compounds that were actually shown to be efficacious or showing to have great effect in true Western medicine.
Matthew: Is there a tool you or your team use that you consider vital to your productivity?
Cameron: Absolutely. So come again, coming from the kind of software background model, we haven't reimposed it yet, we tried to start out with it, but there's a tool actually, that Atlassian puts out called JIRA. And so it actually is the best thing that you can use, in my opinion, for like an agile model background. So what we really do is we kind of divide the team into functional work groups so that you have, you know, people with different strengths and each group which really actually helps decentralize a lot of what we do, but also gives each group ownership of a task like from inception all the way through to completion. Which is great for a number of different reasons, actually. You know, again, let's say great pride of authorship because someone can really take it, you know, that's been their baby, literally from when it was, again, conceived all the way through to when it's actually brought to market or brought to bear under different capacity.
But it also gives us the flexibility with us, like I said, a new study comes out of Israel for let's say, Crohn's disease or something like that, we're able to take one of our teams and in an agile fashion, essentially allocate them to go explore, run that to ground, see what the core elements there are and how we can actually use those internally. So it's been an interesting, I'd say it's more of a function structure. But again, it does fall within essentially that SAS model that you would kind of see you in some sort of a software shop and in an agile environment.
Matthew: Okay, and what is one thought that you have that most people would disagree with you on?
Cameron: So that is actually a super interesting question. I'd be kind of pondering over that one. With respect to, I'd say, my vision for a lot of these different various things is, I think everybody right now is kind of off to a, it's a foot race right now trying to see how far they can get and actually playing a short game, I think in the cannabis industry specifically. Whereas we are really taking the approach of let's build up as large of a, let's say, kind of war chest and everything that of information, why we do have this kind of, let's say, gray period, where we're able to do some, let's say some things that would not be permissible in traditional pharmaceutical arenas, but it will actually help guide us directly. So my plan is essentially to get to an end goal during this before we actually reach a nationalization of legalization nationally program. It is to really address and trying to build up as much knowledge as we can during this time so that we can correctly address and be more informed when that day comes. And so actually, a lot of people are in this I think. That's probably the number one thing that I actually have some major, I say, conflict or ideological differences with people on.
Matthew: Okay. And Cameron, as we close, what's the best way for accredited investors and interested customers to find out more about what you're doing?
Cameron: So we have two separate websites and again, depends on kind of what space you're looking at kind of participating. And so the KelSie Biotech website is kel-sie.com. And so that's, again, our non-plant touching entity, the obviously very small view of any mentions of cannabis on there, but that's actually a real...that's the technology side of things. And then summicrodose.com is the website actually for the product side of things that people are interested in and they're saying, the licensing side, that would probably be the correct thing would be to contact us on the MicroDose. If people are interested in more, let's say technological either investments or some sort of partnership to try and look at things in a more pharmaceutical light, that KelSie website would be the best contact point.
Matthew: Great. Well, Cameron, best of luck to you, you really in an exciting area here and please keep us updated. Come back and come on the show and tell us these things evolve, and there's big breakthroughs and how the products are doing.
Cameron: I'd love that opportunity, and yep, we'll definitely keep you apprised. And hopefully, a couple articles that came out in Forbes over the past months, we are continuing to gain some sort of national recognition here and so we'll definitely keep plowing forward. Thank you for this opportunity, Matt.
Matthew: If you enjoyed the show today, please consider leaving us review on iTunes, Stitcher, or whatever app you might be using to listen to the show. Every five star review helps us to bring the best guests to you. Learn more at cannainsider.com/iTunes. What are the five disruptive trends that will impact the cannabis industry in the next five years? Find out with your free report at cannainsider.com/trends. Have a suggestion for an awesome guest on Canna Insider, simply send us an email at feedback@cannainsider.com. We'd love to hear from you. Please do not take any information from Canna Insider or its guests as medical advice. Contact your licensed physician before taking cannabis or using it for medical treatments. Promotional consideration may be provided by select guests, advertise your company's featured candidates. Lastly, the host or guests on Canna Insider may or may not invest in the companies entrepreneurs profiled on the show. Please consult your licensed financial advisor before making any investment decisions. Final disclosure to see if you're still paying attention. This little whistle jingle you're listening to will get stuck in your head for the rest of the day. Thanks for listening and look for another Canna Insider episode soon. Take care. Bye-bye.


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Piano Concerto No.1 in C major Opus 15 (2) Ludwig Van Beethoven Download 'Piano Concerto No.1 in C major Opus 15 (2)' on iTunes
Classic BRIT Awards 2012: stars of the show
A host of the biggest and brightest stars in classical music are gearing up for their performances at the Royal Albert Hall on 2 October at the Classic BRITs - check out the line-up!
1. Andrea Bocelli
Confirmed as performing at this year's Classic BRITs, Andrea Bocelli will be named international artist of the year to celebrate his 20-year career.
2. Nicola Benedetti
The most nominated British female in the Classic BRIT Awards, the talented violinist is up for Female Artist of the Year this year. She'll also be performing on stage.
3. Russell Watson
He performed on the official Olympic single with Kimberly Walsh, and now he's nominated for Classic FM's Album of the Year in association with MasterCard.
4. André Rieu
André won the Album of the Year award at the Classic BRITs 2011, with Moonlight Serenade, recorded with the Johann Strauss Orchestra, so it's only right that we hear a performance from him!
5. Miloš Karadaglić
Miloš Karadaglić is nominated for two Classic BRIT Awards this year: MasterCard Breakthrough Artist of the Year for 'Latino', and Album of the Year for 'The Guitar'.
6. The Military Wives Choir
It's the first time a single has been nominated at the BRITs and the Classic BRITs, and now the Military Wives are performing at the Royal Albert Hall on 2 October. A whirlwind year!
7. Andrew Lloyd Webber
Andrew Lloyd Webber collaborated with Gary Barlow to write the song 'Sing', featuring the Military Wives, and Gareth Malone. We'll have the pleasure of seeing all the artists reunited at the Classic BRITs this year.
8. Andrew Lloyd Webber and Gary Barlow
Perhaps not an artist who immediately springs to mind as a classical performer, Gary Barlow will be playing one of two grand pianos on stage at the Royal Albert Hall - opposite none other than Lord Lloyd Webber.
9. Gareth Malone arrives at the Classic BRITS Launch
Gareth Malone is set to conduct the special reunion performance of 'Sing', live from the Royal Albert Hall. He's also nominated for an award with the Military Wives!
10. The Phantom of the Opera Cast
The cast of the hit musical will treat the audience to a special arrangement of music from the show, with soloists Ramin Karimloo and Sierra Boggess.
11. The London Chamber Orchestra honour John Williams
John Williams is the winner of a Lifetime Achievement award at this year's Classic BRITs. To celebrate his award, the London Chamber Orchestra, conducted by James Morgan, will treat the audience to a musical montage of his best film music.


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Q: Making sprites inside/outside of a class I've got all my code working on its own. I need to start linking it all to buttons though.
QUESTION: trying to setup multiple buttons as sprites for collision purposes. Don't know how to do it outside of a class.
I have buttons working in seperate classes, but cannot get them to work in the same class for the obvious reason of, the self.image of the second one is overwriting the first one.
class Icons(pygame.sprite.Sprite):
def __init__(self, *args):
    pygame.sprite.Sprite.__init__(self, *args)

    self.image = pygame.image.load("images/airbrushIC.gif").convert()
    self.rect = self.image.get_rect()
    ic1 = self.image
    self.rect.x = 50
    self.rect.y = 490

    self.image = pygame.image.load("images/fillIC.gif").convert()
    self.rect = self.image.get_rect()
    ic2 = self.image
    self.rect.x = 10
    self.rect.y = 540

def update(self):
    pygame.mouse.get_pos()
    pygame.mouse.get_pressed()

This code doesn't have to be a class. But I do not know how to make the images a sprite without being inside of a class. Any help would be appriciated thanks!

A: Instead of Icons you should have a generic Icon class.
Then you can create an instance of Icon for each button.
class Icon(pygame.sprite.Sprite):
    def __init__(self, image_name, pos, cb, cb_data, *args):
        pygame.sprite.Sprite.__init__(self, *args)

        self.image = pygame.image.load("images/" + image_name).convert()
        self.rect = self.image.get_rect()

        self.rect.x = pos[0]
        self.rect.y = pos[1]

        this.cb = cb              # function to call when button is pressed
        this.cb_data = cb_data    # data to pass to the function

    def pressed():
        this.cb(cb_data)

Then in you main function you create the buttons:
ic1 = Icon("airbrushIC.gif", (50, 490), button_pressed, "airbrushIC")
ic2 = Icon("fillIC.gif", (10, 540), button_pressed, "fillIC")
buttons = [ic1, ic2]

def button_pressed(data):
    print "Button pressed:" + str(data)

Last, for every mouse down event you look for a button collition:
for b in buttons:
    if b.rect.collidepoint(event.pos):
         b.pressed()

redpajama_set_name: RedPajamaStackExchange


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/ Uncategorized
/ Tora on how moving to electronic music changed their lives.
Tora on how moving to electronic music changed their lives.
Tommy Boutros 24 September 2019
For starters, this interview occurred over two phases: over the phone and in person when Tora played the Lansdowne on the 12th of September. Therefore, it can be said that this interview is similar to the career trajectory of Tora themselves, as they have, over the past few years, been between two places; Australia and Europe.
The first tier of the interview left much to be desired, anticipation rife. It was clear from the beginning of our phone call that the band's discography runs deep. Channeling the likes of James Blake and Little Dragon, the boys are a long way from their roots.
Originating as an indie rock band based between Byron Bay and Melbourne, it was through constant evolution and a passion to create that saw the band morph into a more electronic based band.
Even though Tora's music is electronic, the boys make a point to play each instrument live. Before I saw Tora play, live instrumentation is a focal point of any band that I see play, for me anyway. It's great to see electronic artists playing their instruments, because quite a few artists hide behind keyboards and essentially press play.
In turn this has helped the band in their ability to play music and their instrumental skills. Jo articulates the transition to a more electronic based production as a turning point in the bands' career thus far. "It made it so that you no longer had to think between what you're human capabilities are. It pushed our instrumental abilities, since what we were writing was so much more complex than what we were playing."
When an improvement in you're ability transpires, it's easy to expect more of you're art. However, Tora's originality has never been in question. They have come together as friends, which saw their music and popularity grow organically. They have managed to stay true to themselves, finding their niche and working on it as a collective.
Tora as a whole are extremely underrated. A band who posses their ability should not only have 2500 (rough) views on one of their live performances of 'morphine' on Youtube.
They are great at every aspect of being a band and their music production is tight. Although, I firmly believe that their most underrated aspect is their songwriting and delivery.
The melodies and tonal literacies the band manages to accentuate their instrumentation with clean words. However, Tora have taken their time to morph into their current space. Starting out as an indie rock band with their origin rooted in Byron Bay, it's safe to say that their sound has evolved and morphed over time.
Loosing a band member would hurt many bands. Tobias has an incredible voice, but since his departure, Jo has really come into himself over the last two albums. In speaking with fellow concert goers when Tora player the Lansdowne the appreciation for Jo's voice runs deep, " Jo's voice is nothing short of angelic."
Jo said over the phone that when he first heard James Blake, his understanding and the way he viewed music and its production changed. "It was around the time I first heard James Blake's first album and Little Dragons first album that a new perspective of music and how it can be put together came to me".
Once Jo came to the realisation that he could follow a more electronic based production approach to music he realised something had to change. "So we moved back to Byron Bay (they were in Melbourne) and began to make music in a studio setup at home with the computer being the tool you use to construct the whole thing."
Jo would go on to say that having a computer as the focus helped their sound morph, "We were just experimenting with an infinite amount of sounds…which naturally made the songs sound like they do."
Shifting to a more electronic based production scheme pushed the band to new levels of musicianship that they had not yet attained. "It allowed us to hone our craft and make these chord progressions and melodies that we wouldn't have been able to make on the fly."
The whole process of recording music into a computer, a more digitised way of creating music allows the chance for further refinement. "It really opened up this new perspective on being able to listen back to what you're creating when you're creating it. It gave us the third person perspective while we were creating."
This helped the band progress as Jo states, "if you're just playing it you really can't hear what is sounds like objectively."
When a band is able to create records that genuinely connect with the listeners, the next natural career progression is to tour their set. There's always been a fear of living that expensive touring life. There have definitely been times when we've tipped over the edge and gone out of balance and thats probably why we've focused on writing music and being in the studio."
"I think we have found a bit more of a balance and we've been preparing for next year where were going to be doing a lot more shows and we've found what makes it a lot more sustainable and what it takes to be healthy and happy." Which ultimately is all we want for each other.
Tommy Boutros
Tommy is a musician and a live music enthusiast, the two often go hand in hand. Writing about music allows him to share his experiences with those absent, hoping to add to Sydney's live music scene.
Read more posts from Tommy Boutros
REVIEW: Shady Nasty
Parcels: On maturing their music, Daft Punk and moving to Berlin
Body Type: On witty comebacks and working in a male-dominated industry
Total Giovanni: On euphoria and the parallel universe of music
AIRPORTS: On Modern Relationships, Blood Disorders & Bangers
Tia Gostelow: On 'Thick Skin' & Finally Writing A Cringy Love Song
Cousin Tony's Brand New Firebird: On Their Name & Their Ethos
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A 'rewarding career': Longtime Mitchell physician Theresa Campbell retires after decades in medicine – Mitchell Republic
Mitchell — Teresa Campbell faced many challenges on her path to becoming a doctor.
But thanks to a few people she calls "angels," Mitchell's longtime doctor overcame obstacles and went on to enjoy a illustrious career that spanned nearly three decades.
After more than 30 years in the medical field, Campbell is about to shed his lab coat and enter the next chapter of his life: retirement.
"I don't know how I would have survived this without Angel. I loved what I did, but I'm ready to retire and be with my grandchildren more." Campbell said.
Looking back on her career, Abella's longtime physician noted her relationships with patients and colleagues as "one of the most rewarding experiences" she's had over the years.
When Campbell entered the medical field in the early 1990s, she said, female doctors were somewhat of an anomaly. But that didn't stop her from pursuing her dream of becoming a doctor.
After opening her practice in Mitchell nearly 20 years ago, Campbell was one of the few female doctors in the Mitchell area. She recalls Campbell encountering subtle signs from others who were unattractive on her path as a doctor, but she broke down barriers and convinced women doctors to stay here. showed.
"I remember some of your looks and statements about me being a doctor. We discovered that there are patients," Campbell said.
The recent promotion of Hilary Rockwell, named CEO of Avera Queen of Peace, was a proud moment for Campbell. She said her Rockwell promotion was a sign of continued progress for women in the medical field, and that progress was being advanced by Campbell and her longtime colleagues, a handful of women. rice field.
In the file photo, Dr. Theresa Campbell speaks with Senator John Thune at the Family Health Center in Abella.
File photo of the Republic
Campbell's ability to overcome life's challenges she faced on her path to becoming a doctor was a trait inherited from her late mother, Patricia Campbell.
In the end, her mother survived the horrors of World War II and was able to escape her London home, which was destroyed in the Nazi-led blitzkrieg of the late 1930s. Her intrepid voyage to America when her Patricia was in her teens inspired her Teresa to keep chasing her dreams no matter what obstacles presented.
"She was a warrior. I learned a lot from her. She was always there to support me.
While attending medical school at the University of South Dakota, Campbell raised her first child as a single mother and maintained good grades. The first angel came into her life that she believes played a major role.
When she was finishing her residency, Campbell met her future husband, Chris Lippert, who is now the director of the operating room at Avella Queen of Peace Hospital. She had more time to focus on her studies because she had more responsibility off her shoulders.
"He did everything. After we got married, while I was still in residency, he did all the cooking, cleaning, and taking care of the kids when I couldn't," Campbell said in her "I would wake up at 6am every morning and study for an hour. Then I would wake my son up and take him to nursery school until a friend volunteered to pick him up."
Lippert was in the process of becoming a nurse when the two began dating. The couple bonded over her passion for the medical field. Little did they know that years later, they would continue working in the same Mitchell medical system.
Coming from humble beginnings, Campbell was determined to become the first doctor in her family.
Campbell's final residency role in Sioux Falls was made possible with the help of a friend who housed her in a house near Colton, whom she calls another pivotal angel.
After completing her residency, Campbell decided to open her own practice at Mitchell, which she said had its own set of challenges.
"We had to sit down every month to figure out what we needed to claim and how many people we needed. Working on the business side was starting to burn me out," Campbell said. said.
When she became more interested in making a difference, Avera Health came along. Campbell jumped at the opportunity to practice family medicine with the Avera Healthcare system.
As the medical field evolved and new technologies such as telemedicine were implemented, Campbell adapted. Some of the newer techniques provided an extensive medical history for each patient. This was an important advance in the field, he said, Campbell.
"When I first started, everything was still handwritten or typed. We use a dictaphone and have someone type everything. Being able to see the drugs you were taking, the tests you had, the doctors you saw," Campbell said. "Technology was always changing."
survive the pandemic
Just when Campbell thought he had seen it all, the pandemic hit in 2020.
Caring for patients amid COVID-19 has been difficult in itself, but Campbell said "people who don't believe in the seriousness" of the virus are the hardest part of getting through it. rice field.
The severity of the pandemic was close to home for Campbell, as a deadly respiratory virus killed her brother at its peak.
"The most difficult thing was the severity of it, so many patients died and some people didn't believe it. "Some people told me it was all fake."
In the midst of a pandemic, face-to-face visits and consultations with patients have suddenly become virtual using telemedicine technology. Like many communities, Mitchell was hit hard, forcing elderly doctors like Lucio Margaro and Campbell into virtual practice at some point.
"The only patients we could see in person were urgent cases or emergency related. I was checking," she said.
Despite the difficult times brought on by the pandemic, Campbell said "nothing will change" about her decision to become a doctor in the community she loves.
Campbell said of her medical career:
Jerome Bettis: Career retrospective | Yardbarker
Tenafly's Rylie Theuerkauf scores her 2,000th career point in loss to Old Tappan


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Meyrargues  es una comuna y población de Francia, en la región de Provenza-Alpes-Costa Azul, departamento de Bocas del Ródano, en el distrito de Aix-en-Provence y cantón de Peyrolles-en-Provence.

Está integrada en la Communauté d'agglomération du Pays d'Aix-en-Provence .

Demografía

La aglomeración urbana se limita a la propia comuna.

Referencias

Enlaces externos
 INSEE

Localidades de Bocas del Ródano

redpajama_set_name: RedPajamaWikipedia


ABSolute Core – The Manual for Developing Unreal Core Strength will give all the essentials on how to develop and maintain an extremely strong, functional midsection and achieve unreal core strength!
Imagine having abs that are as strong as they look. Not only are they flat, rock hard and look great, but they're not just for show. Strong abdominal muscles and the surrounding muscles of the core, boost strength in every activity, protects your back and makes lifting safer. Whether you're moving a refrigerator or lifting weights, your core is the body's amplifier for strength.
If you could get yourself a no bulls*!t manual, that guided you through every detail (the gold is in these details), from the most basic to advanced levels of training that, could get you flatter, firmer and stronger abs in the fastest possible way would you want a copy?
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The fundamentals of bracing. If you're not doing bracing correctly you are essentially putting the brakes on your strength.
The BPC or Back Pressure Crunch this sets you up for fast gains in core strength and flattens the stomach like no other.
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About the Author – Aaron Ellis is a personal trainer, martial artist, blogger and a fitness entrepreneur based in Brisbane, Australia. Founder of Complete-Strength & Guerilla Calisthenics ©. Aaron has been teaching strength training for 15 years. He is a strength athlete, Kettlebell expert, Strength Coach, Russian Martial Art Instructor and former Australian Muay Thai Champion.
Straight to the point, over 50 HI QUALITY photographs accompanied by HIGHLY detailed instructions.


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What is their complimentary breakfast like? What kind of foods/drinks are served? Buffet?
Hi, which if any of your rooms have bathtubs?
Any other options from getting to winery to winery besides renting a car and wine train?
Yes, look up "Napa B Driven" on Google, they are a local company that I've used for past 10 years , a driver will come to your location and then drive you and guest around in your own rental car, they charge much much less than a limo or train . They can also get you into wineries . I highly recommend them. I am a Sommelier by trade and use them often on trips with wife and friends.
Mattfreeman04, we are fully operational and open! We are so saddened by the business and residents who were gravely affected. But we are thankful to not have been directly impacted. A lot of the valley has continued to reopen and the air quality improves every day.


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The Nice Attacker Had a Beard and by That Standard These Men Have Been Radicalized Too
By Sarah A. Harvard
We know two things for sure about the Bastille Day attack in Nice, France, that killed 84 people: The main suspect was a French Tunisian named Mohamed Lahouaiej-Bouhlel and he wore a beard.
The latter may seem like trivial information, despite being the topic of discussion among news networks Monday surrounding Bouhlel and his motives for plowing through a promenade full of people with a truck filled with explosives. The Guardian, for example, recently published an article with the headline "Nice Attacker Grew Beard in Week Before Truck Rampage." The Telegraph, BBC and even Breitbart highlighted the same beard narrative in their stories.
This is a screenshot from the Guardian's article about Mohamed Lahouaiej-Bouhlel. Guardian
The Guardian article emphasized statements from French prosecutors who said Bouhlel grew a beard eight days before the attack and allegedly told his friends he sported it for religious purposes. Prosecutors also described Bouhlel as, at one point, an irreligious man who "ate pork, drank alcohol, took drugs and had a promiscuous sex life."
The fixation on Bouhlel's beard implies that this was his turning point toward terror and radicalization. It inaccurately demonizes and depicts men who simply wear beards as people who are more inclined to commit terrorist attacks. Yes, Muslim men are encouraged to wear beards in Islam just as Muslim women are encouraged to cover their hair. But this has nothing to do with extremist beliefs.
In addition, this perception also filters down to society to the point where Muslims, or non-Muslim black and brown men, are rapidly becoming victims of hate crimes across the United States. It happened this year in Queens, New York, when teenagers attacked a Guyanese Muslim man riding his bicycle allegedly because he was wearing a thobe (traditional prayer robe) and had a beard. In Chicago, Inderjit Singh Mukker, a Sikh man donning a turban and a beard, was beaten and called a terrorist and "bin Laden" by attackers.
This is also perpetuating a troubling hypocrisy: Muslim men are criminalized and brutalized for wearing the beard, when non-Muslim — mainly white men — are glorified for doing the same.
Look no further into BuzzFeed's coverage of beards on celebrities. Articles like "19 of the Most Breathtaking Celebrity Beard Transformations Ever" and "19 Beards That Will Sexually Awaken You" fetishize non-Muslim, mostly white, men for sporting facial hair. It should be noted that not one of the men listed identify as Arab or Muslim.
So if the media and the American public will assume that a Muslim man wearing a beard is "radicalized," then what would we say about these guys?
To be fair, Ryan did get a large amount of hate for sporting a "Muslim beard."
Andrew Toth/Getty Images
The former Daily Show host said he grew out his facial hair after he quit his late night talk show gig. According to People, he grew a beard because that's what everyone who quits talk show programs do.
Gary Gershoff/Getty Images
After retiring from his role as host of The Late Show, Letterman followed in Stewart's footsteps and grew out his beard to the point where he was almost unrecognizable. For Letterman, growing out his facial hair was an act of freedom, which was so often denied to talk show hosts who are groomed and pampered before every late night appearance.
Bieber was having a hard time growing his beard a while back. For what it's worth, he did pause his concert in Istanbul, Turkey, so he wouldn't interrupt the Islamic call to prayer. Bieber showed respect to Islam. Radical!
Vaughn Ridley/Getty Images
Drake must be a secret Muslim. Just look at that photo. That must be a signal of some very suspicious behavior. Perhaps because we're so accustomed to Drake wearing a beard — and he looks so damn good in it — that we were shocked when he spontaneously shaved it.
Sen. Tom Cotton (R-Ark.) is known for his radical right-wing politics, but with his new beard, there's a whole 'nother speculation as to what his heart really loves: America or Islam? In some absurd way, it makes sense for Cotton to publicly advocate for nuking Iran. He didn't want to blow his cover as a radical Muslim.


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2018 midterms Oct. 3, 2018
Trump Wants to Make Sure Midterms Are About Me Me Me
By Ed Kilgore, political columnist for Intelligencer since 2015
Trump has not just conquered Republicans; he dominates them more every day. Photo-Illustration: Konstantin Sergeyev/Intelligencer; Photos: Getty Images
It's a well-established fact that midterm elections are heavily influenced by the natural tendency of voters to undercut the strength of the party controlling the White House. Some of that phenomenon flows simply from the likelihood that opposition-party voters will be "energized" to give their team a comeback. But the size of the almost-universal midterm gains made by "out" parties is highly correlated to the job-approval ratings of the president at any given moment. And with President Trump's ratings apparently stuck in the low 40s for the foreseeable future (they haven't hit 45 percent in the RealClearPolitics averages since March), Republicans have to be worried: Since World War II the average midterm House losses for parties led by a president with approval ratings under 50 percent has been 36 seats. Democrats need a net gain of only 23 seats to regain control of the House.
In this kind of circumstance, it's common for the White House party threatened with losses to try to insulate its candidates — especially in tough districts — from presidential fallout, making the election less of a referendum on POTUS. That is hard to do when the president in question is a figure like Donald Trump, who dominates public discourse to a remarkable extent. And it's even harder when the president is a narcissist who really does want everything to revolve around his imperial self.
As the Washington Post's Philip Bump noted, we got a taste of Trump's craving for a referendum at his rally last night in Mississippi:
"Republicans have to go out and vote. And they say if I was on the ticket, everybody would go. It would be a landslide. Even the fakers back there, they say that," Trump said, referring to the news media.
"And I'm not on the ticket, but I am on the ticket because this is also a referendum about me and the disgusting gridlock that they'll put this country through."
Yes, Trump is clearly trying to energize his own base with such comments (including the ludicrous assertion that the man who won 46 percent of the popular vote in 2016 would win by "a landslide" if everyone voted this year). But it's also obviously a reflection of his narcissism, which he perpetually demonstrates by loudly going his own way in speeches and tweets and policy pronouncements when his party needs him to stay in harness with them or just shut up.
As Bump notes, Trump's willingness to endanger his own party shortly before a perilous election was illustrated in the same speech when he chose to deliver a mocking rendition of Christine Blasey Ford's testimony before the Senate Judiciary Committee.
The decision to disparage Ford was questionable for a number of reasons, but most obviously for political ones….
One of the reasons that Republicans are in such a precarious position is that women broadly prefer Democratic candidates over Republican ones. Women are also more likely to view Trump with disapproval — and women are much more likely to believe Ford's testimony than that of Kavanaugh, Trump's nominee. In other words, Trump not only decided to dismiss Ford's claims, he decided to pour salt on the very issue that has spurred the most antipathy to him and his party from a critical voting bloc in recent weeks.
Perhaps Trump really means his occasional comments expressing disdain for both parties, and is consciously or unconsciously making sure the Republicans have no illusions that they can win votes he doesn't personally win for them. If so, he may soon discover what it's like to have a Congress controlled by people whose disrespect for him isn't muted and denied the way it is today, but is as loud and proud as Trump himself.
christine ford


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Q: Sonarqube 5.3 - Slowness after upgrade After upgrading from Sonarqube 4.5.4 LTS to the 5.3, I noticed an increase of the time to process the analysis of the same project.
Looking into the logs of Backgroud task, seems that it hangs right after this line:
2016.04.05 16:30:26 INFO  [o.s.s.c.s.ComputationStepExecutor] Load measure computers | time=0ms

The same project was normally analyzed in 2-3 minutes when using SQ 4.5.4 but now with 5.3 it's taking 15-20 minutes.
Any idea what could explain this slowness and is there something that could fix it?
PS - I have increased the JVM arguments already to allow the usage of more memory (from 1gb to 3gb)
Thanks!


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Mathematics (4 years)
UCAS Code: G103
Master of Mathematics - MMath
A levelASAccess to HE DiplomaCambridge International Pre-U Certificate - PrincipalExtended ProjectGCSE/National 4/National 5International Baccalaureate Diploma ProgrammeLeaving Certificate - Higher Level (Ireland) (first awarded in 2017)Pearson BTEC Diploma (QCF)Pearson BTEC Extended Diploma (QCF)Pearson BTEC Level 3 National Diploma (first teaching from September 2016)Pearson BTEC Level 3 National Extended Certificate (first teaching from September 2016)Pearson BTEC Level 3 National Extended Diploma (first teaching from September 2016)Pearson BTEC Subsidiary Diploma (QCF)Scottish HigherWelsh Baccalaureate - Advanced Skills Challenge Certificate (first teaching September 2015)UCAS Tariff
A-levelASAccess to HE DiplomaCambridge International Pre-U Certificate - PrincipalExtended ProjectGCSE/National 4/National 5International Baccalaureate Diploma ProgrammeLeaving Certificate - Higher Level (Ireland) (first awarded in 2017)Pearson BTEC Diploma (QCF)Pearson BTEC Extended Diploma (QCF)Pearson BTEC Level 3 National Diploma (first teaching from September 2016)Pearson BTEC Level 3 National Extended Certificate (first teaching from September 2016)Pearson BTEC Level 3 National Extended Diploma (first teaching from September 2016)Pearson BTEC Subsidiary Diploma (QCF)Scottish HigherWelsh Baccalaureate - Advanced Skills Challenge Certificate (first teaching September 2015)UCAS Tariff
A,A,A-A,A,B,B
Typical Offer: AAA or AABB including Mathematics (minimum grade A) If you are taking an EPQ in addition to 3 A levels, you will receive the following offer in addition to the standard A-level offer: AAB to include grade A in the EPQ, and including Mathematics (minimum grade A) Contextual Offer: AAB including Mathematics (minimum grade A) We are committed to ensuring that all students with the potential to succeed, regardless of their background, are encouraged to apply to study with us. The additional information gained through contextual data allows us to recognise a student's potential to succeed in the context of their background and experience. Offers typically exclude General Studies and Critical Thinking. If an additional Mathematics qualification (STEP grade 2/MAT/TMUA) is taken alongside three A-levels then the offer will be AAB including Mathematics (minimum grade A). We accept any of the three STEP papers. For more details about the STEP and TMUA papers see the Admissions Testing Service Website.
The University of Southampton recognises the educational value of taking AS Levels alongside three A-levels and the breadth of studying additional subjects, however all of our programmes express their entry criteria in terms of three subjects offered at A Level with selection decisions being informed, in part, by actual or predicted grades in those subjects (excluding General Studies, Use of Mathematics, and Critical Thinking).
Typical offer: 60 credits with a minimum of 45 credits at Level 3, all of which must be at Distinction Mathematics must be studied to level 3, A-level standard
D3 D3 D3 in three Principal subjects including Mathematics at D3 Cambridge Pre-U's can be used in combination with other qualifications such as A Levels to achieve the equivalent of the typical offer
Extended Project
The University of Southampton values the Extended Project Qualification. Applicants taking the EPQ in addition to three A Levels may also be made an alternative offer one grade below the standard offer, conditional on an A grade in the EPQ.
Applicants must hold GCSE English language (or GCSE English) (minimum grade 4/C) and mathematics (minimum grade 4/C
Typical offer: Pass, with 36 points overall with 18 points at Higher Level, including 6 at Higher Level in Mathematics International Baccalaureate Career-related Programme (IBCP): Offers will be made on the individual Diploma Course subject(s) and the career-related study qualification. The CP core will not form part of the offer. Where there is a subject pre-requisite(s), applicants will be required to study the subject(s) at Higher Level in the Diploma course subject and/or take a specified unit in the career-related study qualification. Applicants may also be asked to achieve a specific grade in those elements. Please see the University of Southampton International Baccalaureate Career-Related Programme (IBCP) Statement for further information. Applicants are advised to contact their Faculty Admissions Office for more information.
H1,H1,H2,H2,H2,H2
Typical offer: H1 H1 H2 H2 H2 H2, to include Mathematics at H2.
Pearson BTEC Diploma (QCF)
DD in the BTEC Diploma plus A in A-level Mathematics
Pearson BTEC Extended Diploma (QCF)
DDD in the BTEC Extended Diploma plus A in A-level Mathematics
Pearson BTEC Level 3 National Diploma (first teaching from September 2016)
DD in the BTEC National Diploma plus A in A-level Mathematics
Pearson BTEC Level 3 National Extended Certificate (first teaching from September 2016)
D in the BTEC National Extended Certificate plus AA from two A levels including Mathematics (minimum grade A)
DDD in the BTEC National Extended Diploma plus A in A-level Mathematics
Pearson BTEC Subsidiary Diploma (QCF)
D in the BTEC Subsidiary Diploma plus AA from two A levels including Mathematics (minimum grade A)
Offers will be based on exams being taken at the end of S6. Subjects taken and qualifications achieved in S5 will be reviewed. Careful consideration will be given to an individual's academic achievement, taking in to account the context and circumstances of their pre-university education. Please see the University of Southampton's Curriculum for Excellence Scotland Statement for further information. Applicants are advised to contact their Faculty Admissions Office for more information.
Welsh Baccalaureate - Advanced Skills Challenge Certificate (first teaching September 2015)
Typical offer: AA from two A levels including Mathematics (minimum grade A) and A from the Advanced Welsh Baccalaureate Skills Challenge Certificate
Working with world-class researchers, this 4-year programme will take you to the cutting edge of knowledge in Pure or Applied Mathematics or Statistics, pushing you much further than the traditional 3-year course. You will develop your skills in analytical, abstract and structured thinking in a programme that covers the full range of mathematics from modern cryptography to the modelling of black holes.
With a structured foundation of algebra, calculus, number theory, statistics and mathematical modelling you will acquire skills and knowledge in an exceptionally broad range of topics in the mathematical sciences. In the fourth year, you will have the opportunity to study advanced concepts such as group theory, general relativity and survival analysis that are otherwise studied at MSc level.
Southampton graduates from this programme are highly sought after by employers in finance, commerce, industry, and education, and are particularly well placed to follow careers in research.
The first three years of the course are similar to the BSc Mathematics programme, but in the fourth year you will have a much more prominent part in the direction of your studies and it will involve studying challenging Masters level mathematics. You will undertake an individually supervised project on a topic, which you can choose, and several of the lecture courses involve directed self-study and reading involving such topics as hyperbolic geometry, differential geometry, asymptotics and continuum mechanics. The final year as a whole will equip you with many of the skills you need in a career as a professional mathematician.
The module page gives a brief outline of the structure of the programme. For more details and regulations pertaining to this degree programme see the programme specification link on the Programme Details Tab.
https://www.southampton.ac.uk/maths/undergraduate/courses/g103_mmath.page#modules
You will be assessed in a variety of ways such as coursework, tests and exams, enabling you to demonstrate your strengths and show what you have learnt.
Main Site - Highfield Campus
Study in Southampton
Explore Southampton
Want to feel needed? This is one of the most flexible degrees of all and with so much of modern work being based on data, there are options everywhere for maths graduates. With all that training in handling figures, it's hardly surprising that a lot of maths graduates go into well-paid jobs in the IT or finance industries, and last year, a maths graduate in London could expect a very respectable average starting salary of £27k. And we're always short of teachers in maths, so that is an excellent option for anyone wanting to help the next generation. And if you want a research job, you'll want a doctorate — and a really good maths doctorate will get you all sorts of interest from academia and finance — and might secure some of the highest salaries going for new leavers from university.
What's it like studying a degree in Maths
Mathematics (MMath) with a Placement Year


The candidate must have possess a high level of academic achievement, solid law firm experience, and superb writing and communication skills. Must have 3+ years of broad transactional real estate experience.
Seeking a Collections Attorney to help with receivables. Illinois license is required.
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The candidate will have 3 to 6 years insurance coverage experience ? commercial general liability or property experience preferred.


The organisational review of the Science and Technology Facilities Council (STFC) was announced by the Department for Business, Innovation and Skills and STFC in June 2008. The announcement was made in the Government response to the inquiry by the Innovation, Universities, Science and Skills Select Committee into the Science Budget Allocations in the last comprehensive spending review .
The review was conducted as a two stage process, where STFC first prepared a self assessment document against criteria agreed with DIUS. In the second stage, the self assessment document was considered by a Panel of external experts, charged with reaching an independent view on the organisation of STFC.
The STFC Self Assessment Report is available here. Download the report .
The Report of the External Review Panel is available here. Download the report .
The STFC response to the Report is available here. Download the response .


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