text:
Home | Database | Genweb | Blog | Facebook | Search | Index of Persons | Surnames
Index of Persons
148884 individuals, 59271 families from file 20220115.ged (15 Jan 2022)
Sarah Field (____ - ____)
Sarah Field (16 Mar 1734/1735 - ____)
Sarah Jane Field (Jul 1842 - 17 Aug 1912)
Sophia Field (19 Apr 1793 - 25 Sep 1794)
Sophia Field (ABT 1805 - 24 Jul 1870)
Stephen Field (____ - 10 Sep 1727)
Stephen Field (ABT 1761 - 7 Apr 1833)
Susanna Field (ABT 1736 - 30 Jun 1789)
Thomas Field (3 Jan 1670 - 17 Jul 1752)
Thomas Field (ABT 1696 - 20 May 1777)
Thomas Field (____ - 10 Aug 1717)
Thomas Field (7 Apr 1741 - 27 Jun 1833)
Thomas Field (Jr.) (1778 - 6 Dec 1858)
Van Buren Field (21 Jan 1894 - Jul 1979)
Wait Field (24 May 1744 - 19 or 20 Jul 1819)
Waldo Field (8 Mar 1791 - ____)
Waldo Field (Jr.) (9 Feb 1821 - ____)
Waterman Field (20 Oct 1772 - 15 Sep 1837)
William Field (____ - ____)
William Field (8 Jun 1682 - 1 Nov 1729)
William Field (20 Apr 1728 - 18 Apr 1816)
William Field (28 Jul 1753 - Jan 1808)
William Field (18 Apr 1790 - ____)
William Field (____ - BEF 12 Jun 1999)
William H. Field (1837 - 1903)
William M. Field (ABT 1790 - 30 Aug 1842)
Zuba Field (21 Dec 1769 - 21 Aug 1771)
Alice Wilson Fielden (29 Jul 1858 - ____)
Jessie M. Fielden (Aug 1860 - 4 Aug 1942)
Robert S. Fielden (ABT 1831 - 28 Jan 1863)
Samuel Fielden (____ - ____)
Georgiana May Fielding (ABT 1886 - AFT Apr 1940)
Henry Fielding (____ - BEF Apr 1910)
Audrey Elizabeth Fields (4 Feb 1917 - 3 May 1993)
Eddie Fields (____ - ____)
Francis F. Fields (15 Mar 1876 - 11 Dec 1957)
Harry Earl Fields (12 Apr 1912 - 11 Dec 1980)
Jerry Earl Fields (____ - ____)
Lucinda Fields (25 Apr 1850 - ____)
Christen Fieldsted (Oct 1822 - AFT Aug 1902)
Margaret de Fienes (____ - ____)
Margaret Fiennes (1540 - 10 Mar 1611/1612)
Thomas Fiennes (Sir) (____ - ____)
Ethel N. Fife (27 Jun 1920 - ____)
Frederick C. Fife (1 Aug 1900 - Nov 1986)
Carrie Fifield (12 Jan 1834 - 18 Mar 1898)
Jeffery William Fifield (____ - ____)
Mary Fifield (____ - ____)
Simon Fifield (____ - ____)
Tyler Patrick Fifield (____ - ____)
Adeline Rose Figil (____ - ____)
Emily Fike (____ - ____)
Charles W. Filer (____ - ____)
Thomas Henry Filer (10 Jun 1873 - 22 Jul 1874)
Claire Files (____ - ____)
Frank S. Filkins (12 Feb 1838 - 20 Feb 1905)
Abigail Fillbrook (____ - ____)
James R. Fillmore (____ - ____)
Ronald Robert Fillmore (Sr.) (23 Mar 1920 - 25 Jun 2000)
Fred Williams Filoon (26 Sep 1870 - 22 Apr 1938)
John Whipple Filoon (13 Jun 1906 - 19 Dec 1962)
Abigail Finch (14 Nov 1823 - 4 Dec 1892)
Alpheus Finch (____ - ____)
Betsy Finch (29 Dec 1795 - 11 Feb 1859)
Calvin Dee Finch (____ - ____)
Curtis Finch (Jr.) (____ - ____)
David Shane Finch (____ - ____)
Dee Finch (____ - ____)
Henry Finch (____ - ____)
James Allen Finch (____ - ____)
John D. Finch (Bet 1890 and 1894 - ____)
Kelly Scott Finch (____ - ____)
L. Boyd Finch (____ - ____)
UP (Oliver Felt - Bradley Gilmore )
BACK (Hannah Field - Sarah Field )
NEXT (Leslie Finch - Cyrus Root Fish )
Email corrections and additions to webmaster@whipple.org
© Whipple Website. All rights reserved.
HTML created by GED2HTML v3.6-Linux (Mar 8 2001) on Sat Jan 15 19:11:43 2022 GMT.


De Vleugels, an expertise and support centre for people with intellectual and/or multiple disabilities, is the first centre of its kind to choose Edumatic and the advantages of the EduQare community.
De Vleugels guarantees a qualitative and warm support for people with disabilities. To achieve that, the expertise of their employees plays an important role. Therefore, De Vleugels invests in the online interactive learning, practice and test platform of Televic Education and enjoys the advantages of the EduQare community.


text:
Consulting | Coaching | Communicating
Add fire, vitality, and strength to your leadership and marketing goals with Carmine Media
Brand Collabs
Professional Voiceover Talent
Leadership Coaching for Women
Free Aggressive vs. Assertive Chart
Free Gender Workplace Communications Chart
Free Chart: Common Types of Biases Women Face at Work
Free Relationship Mapping Grid
My Merch
Complaining Customers and Social Media: How to Make Them Happy Again
Posted on December 17, 2020 December 31, 2020 by Sue Reynolds
Dealing with customer complaints as they arise is a critical part of maintaining your brand's reputation. Survey data suggests that at least 4 out of 5 consumers will reverse a purchase decision based on negative reviews. Therefore, it's important to have a strategy set in advance for negativity or complaints in your social media feeds so you aren't taken by surprise or reacting with emotion first. If you're looking for more, Jay Baer has written an entire book, Hug Your Haters, on the subject, which I highly recommend. When dealing with complaints, keep the following in mind to get the best results for both your customer and your business.
Get Past the Anger
Sometimes, the hardest part of dealing with a customer complaint is avoiding becoming defensive. The truth is, you cannot assume that because a customer is angry their complaint is invalid. Ask yourself what caused the problem — did your customer service fail them, was your website's copy unclear, or was it an operational problem? Identify the exact failing that brought them to this point. Don't dismiss a complaint because a customer may be less than articulate in expressing their frustration. Try to dig and find out why.
Track and Record the Complaint
Some customers will complain repeatedly. Some are chronic complainers online while others have truthfully encountered every problem that exists with your product or service. Being able to sort through these complaints requires organization and consistency across all channels. If you're running a small business, think about using a cloud -based software to keep records of customer preferences and history to provide a consistent customer service experience. If you're a corporate social media community manager, make sure you're able to record your customer service interactions on your corporate customer service platform. Break down those silos. In either case, being able to track and sort your interactions will help you make process decisions to improve quality overall.
Take Responsibility for Their Experience
Nothing upsets a customer with a complaint like being told the problem is their fault or sweeping the complaint under the virtual rug. On social media it can be tempting to delete the offending comment. Instead, go back to step one and try to find out more. When responding use language that shows you are listening and genuinely want to help. If you know you or your company messed up, opt for language that instantly defuses frustration by accepting blame: "I am sorry our product did not meet our normal standard of quality," or even a simple "We are sorry to disappoint you." Then, take the conversation offline as soon as possible. Route them to your customer service team or have them message you an email or phone contact and continue the conversation there. Your social media audience will appreciate the transparency and your angry customer will feel heard.
Automation has made our lives easier, but can also leave customers in limbo. HelpScout reports found on a Harris Interactive poll that 75 percent of customers believe it takes too long to reach a live agent. While this is a subjective response coming from frustrated customers, the lesson is still clear. Connect upset customers with an actual person as soon as possible. If you're on social media, try to respond within 30 minutes of their original post. If you're transferring a customer via phone keep it under two minutes. Be sure they understand the next person will be better suited to helping them. There is nothing worse than waiting for an answer, especially when you are frustrated. There's also nothing worse than getting stuck in a circle of customer service automation, which happened to me recently. If you'd like to read my rant about being human, here you go!
Customers have more avenues to complain about your products and services than ever before. Make sure you are capturing all those conversations and responding in a way that diffuses the situation and provides an agreeable solution. The best possible outcome? You'll turn that complaining customer into a customer advocate for life.
If you have questions about how to listen for and respond to complaints on social media feel free to contact me. I'm happy to work with you to set up a reputation management plan.
Posted in Blog, Social Media Marketing
The Answer to Setting up Multiple Social Media Profiles
Social Media Security: The Difference Between Spoofing and Hacking
Why Carmine?
Carmine is a pigment of bright red color, signifying strength, fire and vitality.
10 Proven Tips for a Successful Annual Review: How to Prepare, Engage, and Follow-Up January 23, 2023
10 Tips for Improving Your Public Speaking Skills: From Preparation to Perfection January 17, 2023
Top 5 Skills You Need To Move From Manager To Director January 5, 2023
2023 Book Recommendations for Learning, Leading, and Leisure December 26, 2022
Top Social Media Marketing Trends for 2023: Video, Personalization, Social Commerce, and User-Generated Content December 22, 2022
2023 Copyright |Carmine Media, LLC. All Rights Reserved
My Instagram Feed ❤❤
When you lose a parent part of your mourning is the loss of your childhood. I'm incredibly thankful to have my sister with me to share in this experience. Our shared history reminds me I'm not alone.
Talking yourself up isn't bragging or selfish. You need to be able to articulate your accomplishments and value. Don't assume leadership is aware of what you're doing. You're awesome and leadership needs to know that!❤
There's something surreal about being in your hometown dealing with the loss of a parent. Funeral planning, going through old photo albums, visiting family, dealing with grief and the bittersweet loss of childhood, all while the world keeps spinning and people go on with their daily lives.
It's with much love and a heavy heart that Karen and I share the passing of our mother Mary early this morning. She was comfortable and at peace and wanted desperately to be with our father again. We were able to be with her as she fell asleep to make that journey.
It can feel very strange to move from a doer of things to a leader of people, and at first you might feel like you aren't doing anything! Remember it's your job to give the team the tools and resources they need and encouragement to succeed.
I am not afraid. I was born to do this. Joan of Arc.
2023 (c) Copyright | Carmine Media, LLC. All Rights Reserved | Privacy Policy
Sign up for my emails to register for upcoming sessions and to gain access to helpful tips.

redpajama_set_name: RedPajamaCommonCrawl


text:
2021 Computer Science Internships in Philadelphia, PA
Do you enjoy building new algorithmic processes? Do you like thinking about computational theories and how they can scale to solve big technical problems? If your answer is yes, then you're a perfect candidate for a computer science internship. But what does an internship in computer science involve and what types of companies can you work for? A CS internship can take you down a lot of different paths, often depending on what type of programming languages you currently use and which you want to learn. Whether you are a front end coder, using Java and CSS, a back-end coder who currently works with Ruby, Python, or Scala, or a mobile developer who knows how to build on either the Android or the iPhone platform, there are a lot of ways you can make an impact at companies of various sizes. Chances are, by holding an internship in computer science, you'll be working with several of these languages and learning the intricacies of each from veterans with plenty of experience in the field. The really exciting thing about a computer science internship is the range of different companies to work for. Whether it's a small startup, that needs extra hands to help push new code daily, or a large non-profit that needs a tech savvy student to build new site features, your skills will be in high demand during your computer science internship and there will be no shortage of challenges or learning experiences. One of the other great aspects of being a computer science major is that your skills are in high demand. According to a recent Forbes study computer science majors are one of the top 10 most sought after hires, and often are getting paid some of the most competitive wages in the country for both jobs and internships. Average salaries tend to be in the $15 to $17 per hour range, but a really talented hacker can make up to $30 an hour at leading tech companies in Silicon Valley or Fortune 500s on the east coast or elsewhere. With an internship in computer science, you will also be able to explore one of the many sub-fields such as computer graphics, computational problems, software engineering or quantitative analysis. So whether or not you're a hard-core techie, any of the many CS internships will be the perfect start to developing a diverse skill set in relationship to writing code and advanced programming.
External Job
Red Tettemer O'Connell Partners
Web Dev Intern
CYBERSECURITY AND PRIVACY INTERN - SUMMER 2021
U.S. Public Interest Research Group
PennPIRG Internship Program
UHS Corporate Office
Network Administration Intern *Opportunities Available*
Data Analytics Intern *Opportunities Available*
System Administration Intern *Opportunities Available*
Information Security Analyst Intern *Opportunities Available*
NAIOP Greater Philadelphia
Intern, Government Relations (Part-Time)
RELX Group
Product Management Intern
PCS GLOBAL TECH
Opportunities in Microsoft BI and Data Analysis for Fresh Graduates
Explore 2021 Computer Science Internships
Remote Computer Science Internships
Colleges and Universities in Philadelphia, PA
La Salle University
More Related 2021 Internships
Computer Science Internships
Philadelphia, PA Internships
More 2021 Computer Science Internships in Nearby Cities
Computer Science Internships in Pittsburgh, PA
Computer Science Internships in Erie, PA
Other Categories of 2021 Internships
Research Internships in Philadelphia, PA
Animal Care Internships in Philadelphia, PA
Health Internships in Philadelphia, PA
Coaching Internships in Philadelphia, PA
Non-Profit Internships in Philadelphia, PA
Social Work Internships in Philadelphia, PA
Retail Internships in Philadelphia, PA
Public Health Internships in Philadelphia, PA
Sales Internships in Philadelphia, PA
Cosmetology Internships in Philadelphia, PA
Real Estate Internships in Philadelphia, PA
Mechanical Engineering Internships in Philadelphia, PA
Supply Chain Management Internships in Philadelphia, PA
Computer Hardware Internships in Philadelphia, PA
Ambassador Internships in Philadelphia, PA
Wildlife Internships in Philadelphia, PA
Radio Internships in Philadelphia, PA
Medical Internships in Philadelphia, PA
Museum Internships in Philadelphia, PA
Photography Internships in Philadelphia, PA
Apply to jobs. Hear back every time.
About UsPressCareersPay The Interns
Entry Level JobsInternships
Product of WayUp, Inc. © 2021
Made with in New York City


text:
Carlos Augusto León Arocha (Caracas, October 20, 1914 – May 13, 1997) was a Venezuelan poet, essayist, historian, politician and scientist.

He gained a doctorate degree in physical science and mathematics from the Central University of Venezuela in 1936. He also gained a teaching degree in history and geography from the National Pedagogical Institute, and taught for over 5 years at the Andrés Bello Lyceum School in Caracas. In the last twenty years of his employed life he worked as a professor of contemporary literature at the Central University of Venezuela, an institution in which he also served as director of the Department of Publications.

In the second half of his life Augusto Leon was preoccupied with writing poetry and being outspoken in politics, particularly in defense of the common people and disadvantaged social groups. During the dictatorship of General Marcos Pérez Jiménez he was imprisoned and then exiled for a long time. He took advantage of his time in exile by taking his political message and poetic word to many Latin American and European countries. In 1953 he traveled to Russia where he was awarded the World Peace Council Prize. He later returned to Venezuela and held notable political posts, such as City Council member of Caracas and then Senator in the National Congress.

As in his politics, Augusto León's poetry carried a social message, characterized by its defense of the common people.

Literary Awards
 National Prize for Literature (1949) for his poem A solas con la vida.
 Municipal Prize for Prose (1946) for his essay Las piedras mágicas, which pays tribute to the life and work of the Venezuelan writer José Antonio Ramos Sucre.

Works
 Los pasos vivientes (México: Ed. Morelos, 1940)
 Canto de mi país en esta guerra (Caracas: Ed. Suma, 1944)
 Homenaje a Jorge Manrique (Caracas: Ed. Bolívar, 1947)
 Los nombres de la vida (Caracas: Ed. Séneca, 1947)
 La niña de la calavera y otros poemas (Caracas: Litografía del Comercio, 1948)
 A solas con la vida (Caracas: Ed. Ávila Gráfica, 1948)
 Canto a Corea (Caracas: Tipografía Vargas, 1949)
 Canto de paz (Caracas: Ed. Ávila Gráfica, 1950)
 Tres poemas (Caracas: Tipografía Vargas, 1951)
 Poesías (México: Ed. Beatriz de Silva, 1954)
 Solamente el alba (Caracas: Universidad Central de Venezuela, Dirección de Cultura, 1973)
 Una gota de agua (Caracas: Imprenta Universitaria, 1974)
 Los dísticos profundos (Caracas: Ediciones de la Presidencia de la República, 1984)
 Juegos del yo (1989)

References

1914 births
1997 deaths
20th-century Venezuelan poets
People from Caracas
Central University of Venezuela alumni
Academic staff of the Central University of Venezuela
Venezuelan politicians
Venezuelan essayists
Male essayists
Venezuelan male poets
20th-century essayists
20th-century male writers

redpajama_set_name: RedPajamaWikipedia


Just another manic Monday? Half price parmi will cure all.
Quarterdeck is the place to be every Monday for half price parmi! Succulent chicken in a panko and parmesan crumb topped with double smoked Casalingo ham, shredded mozzarella and Napoli sauce with crispy beer battered chips and fresh salad. Heaven.


The nutcases at Nabisco are at it again! Last time I wrote about Oreo cookies, I covered the Cookie Dough and Marshmallow Crispy flavors. This summer, Nabisco has brought us Cotton Candy and S'More flavored Oreos. I obviously needed to eat these.
Before digging in, I had my reservations. All I could think about was how disappointed I was with the Cookie Dough flavor (which has been recently re-released). I didn't want to face that same disappointment, especially with the S'Mores flavor.
In a pitcher, mix the lemonade drink mix, whiskey, peach schnapps, and syrup. Stir until the drink mix and syrup are dissolved. Add in the ice and wine coolers. Stir well.
Leave in refrigerator for 2 hours.
Pour into glasses, and serve to your dinner party guests. Perfect way to clear out a barbecue after everyone has overstayed their welcome.
Last August, I compiled a top ten list of my favorite RiffTrax VoD releases. I had a pretty solid list at that time, too. Since making that list, however, they have released sixteen new movies and I knew I had to update my list.
This was not an easy venture. You know those scenes in movies and TV shows where there is a group of people trying to come up with an idea or a verdict in a murder trial, and they are just arguing the whole time? There is always one guy just sitting there, with his head resting on one or both of his hands, trying to make sense of it all. I was that guy while working on this list. I was also everyone else arguing with each other. Honest to God, this list took me two and a half weeks to finalize.
I am glad I don't work under any sort of deadline.
In the end, only four of the releases from the first list have survived. The rest are all from the last nine months.
Be sure to argue my list in the comments or on Twitter.
Today is National Apple Pie Day, and we figured we would help you celebrate the BS way with our latest creation!
Scoop the apple sauce into a glass. Slowly stir in the Pucker and the Applejack.
Add the coating of crushed cereal to the top.
Much like the Chunky Piña Colada before it, this one will probably require a spoon.
One of these a day won't keep the doctor away. In fact, it will probably send you to the hospital.
Two years ago, on May 16, our first Bottom Shelf review was published. Bottom Shelf Russ put his liver and various other internal organs on the line to review Fleischmann's Whiskey. Two years later, the spirit The Bottom Shelf lives on with Bottom Shelf Mixology.
Through those two years, we have had twelve cheap whiskey reviews, The Whiskey Games Tournament, and twenty-nine drink recipes. With that many articles, it's hard to find and read all of them. Because of this, I have assembled this list of everything Bottom Shelf.
When you pour this into a small glass, throw in a handful of culantro.
Drink to celebrate El Día de la Batalla de Puebla, and get a guaranteed hangover for Seis De Mayo!


One of the reasons why it is so popular with the masses is because of its themes. A WordPress theme is a collection of files working together to create a graphical interface with an underlying unification style for your blog. Depending on lots of aspects including your spending plan, you can select between setting up premium WordPress themes or get WordPress themes complimentary of charge. In either case, you can not go wrong when you integrate WordPress themes for business. Occasionally, WordPress develops themes for their complimentary hosting site, in addition to for their premium website WordPress.org, They also enable third-party designers to produce and provide their premium or free responsive WordPress themes. Let us move gears and examine a few of the very best WordPress themes offered for download; totally free and premium.
This is a fun theme to install on your website, and it consists of a host of incredible micro-interactions that boost the user experience of your visitors. This makes it a multipurpose theme appropriate for a vast array of imaginative projects. Currently, it ranks as one of the best WordPress blog themes for a marketing company along with for small companies and start-ups.
This is an ideal theme for small businesses dealing with computer system and electronics repair. It comes total with a tidy layout, minimalistic style, and numerous sections for showing all the services on offer. Personalization is easy, and you can have your brand name colors established in a couple of clicks. It includes WooCommerce combinations, and you can move around the items on your WordPress website design to fit your requirements and customer expectations.


We question the effort to date the lower part of a core from the Baltic Sea with a combination of tephra layers and stratigraphical markers. No geochemical data is presented for the two tephra layers, believed to be the Saksunarvatn Ash and Vedde Ash. Furthermore, the age used for one of the stratigraphical markers is erroneous. We present two alternative age models, of which the second gives a plausible sediment accumulation rate but excludes the identification of the Vedde Ash.


An article by Gabez, posted on July 15. 2004.
We�ve heard it all before. 3D is the way forward, not 2D! Forget 2D! It�s ancient! It�s old news! Only baby-eating barbarians living in huts in 6th century AD England use 2D! That�s how old it is! In fact, to illustrate my point through the magic of the analogy, 2D is the man who unblocks all the waste from your toilet, and 3D is some hunky underwear model living in Madrid! Superfluous use of exclamation marks and long drawn-out analogies aside, the point is that 3D is undoubtedly the way to go.
Just look how far Half-life�s graphics have come on � why shouldn�t Monkey Island be the same?
...Or is it? Okay, so admittedly 3D is necessary for games like Half-life and Black & White, but there nevertheless remains a question over whether adventure games really need it. Most of the them are, after all, just a series of locations strung together through a maze of puzzles � nothing in there to warrant fancy 3D upgrade-or-you-won�t-be-able-to-play-it graphics. The way of the adventure game needs to change, though (see my article "Evolve or die"), and so maybe the concept of using three dimensions in an adventure game needs to be more seriously addressed by this community.
But before we begin on this tour de force of intellect that is this article, a brief lesson in the wonderful world of dimensions is necessary. First, what do we actually mean by three dimensions? Well � technically speaking, the computer 3D is actually 2D, as the images are presented to us on our flat screen showing only width and height, but that goes without saying really. Instead, when we say "3D" we mean that the computer visualises the object in the game as having width, height and length, which means that it can be told to, say, turn said object 90 degrees to the left, thus revealing more of the object.
�Phwoar, look at those legs� � a non-cut scene screenshot from Half-life 2 demonstrating how 3D can be pushed to the most amazing limits.
In 2D terms, the computer is told nothing of the sort. If asked to turn the object it would yell back at you that it can�t, because it doesn�t have any data outside the two dimensional parameters. Instead, the animator would have to fool the player into thinking that the computer thought that there were three dimensions by, er, animating three dimensions even though, according to the computer, there are only two. Stop if I�m going too fast for you.
There also seems to be general confusion about the other dimensions out there: one rather enthusiastic forum poster called out to LucasArts to �KEEP IT 1D�. This is, of course, ridiculous, unless we want Guybrush to take the form of a line stretching out onto infinity for his next outing. Similarly, no dimensions must also be ruled out for Monkey Island 5�s graphics, as this dimension consists of but a single point in space. It would simply not suffice. The fourth dimension is time and space, which the third dimension needs in order to show change. The fifth dimension is right out.
Just from that very brief (and largely inaccurate, I�d wager) lesson on dimensions, we can already spot a problem for a 2D adventure game. Since the animator has to "fool" the player into thinking that the objects presented on the screen are 3D in the game world, it can seriously limit the amount of freedom the player can take in the game. The way Guybrush rotated in Escape from Monkey Island would, for example, have been very difficult to accomplish in a 2D engine. 3D can do more than rotate Guybrush, though � and it has to be said that EMI didn�t make full use of the possibilities that 3D can give.
What Monkey Island 5 could look like (screenshots from Farcry).
Imagine running through Blood Island in a 3D game engine. You can hear the screams of the sea-gulls through your left speaker and the howl of the wind in your right, thanks to the 3D sound. The camera smoothly follows you as you march from the beach to the graveyard, as opposed to the old map method of transportation. Sand is kicked up beneath your feat, leaving foot-prints and sending bits of rubble everywhere. The palm-leaves rustle realistically in the breeze. You move off the path and come across a monkey, which you can view from any angle imaginable. A vampire bat dramatically swoops down and grabs the monkey. You follow it to a cliff, where you accidentally stumble and fall into the ocean.
Exciting? You betcha. Unrealistic? Not at all. Just look at Far Cry or any other modern first person shooter, where the environment is enhanced no end by the 3D engine. What�s more is that those games have to include a massive game world, whilst a 3D Monkey Island game would only have to include a gaggle of relatively small islands, meaning that more time could be spent on making the locations come alive. I mean, when you played Curse of Monkey island, did you feel like you were actually there, or did it just feel like you were controlling a 2D character through a series of rather beautiful paintings? Granted, the sound and art helped make the whole experience more groin-grabbingly engrossing, but 3D can make it feel so real you�ll never want to leave.
Myst 4 may look beautiful, but its lack of a proper 3D engine means that its beauty is still on skin-deep.
Another important point I need to make is this: there has never been a 3D Monkey Island game. Escape from Monkey Island was not 3D. It was 2D with bells on. Okay, okay, the characters may have been 3D, but nothing else was. The movies were originally 3D, but were then saved as 2D � this basically means that if I wanted to choose what I wanted to say during a cut-scene, I wouldn�t be able to. If the cut-scenes were done in 3D, this would be possible � and I know what you�re thinking � �but Gabez, then it wouldn�t have looked so good�. Wrong! 3D interactive cut-scenes can be done whilst at the same time looking fantastic. You�ll never get the cut-scene to look as good as it would were it done in the �3D then 2D� way, but it�s worth it, I reckon, to involve the player at every possible moment. That is, after all, what makes adventure games so good.
The backgrounds were also done in this way � made in 3D, then saved as 2D, or �pre-rendered� as it�s known as in jargon land. This not only looks shite, but it also severely limits the player, as the backgrounds are nothing but just that � backgrounds. It�s hard to make the palm-tree sway in the wind, or create a dent in the side of a building when you punch it, and it�s certainly impossible to have the camera follow the protagonist as they explore the world. In fact, it�s hardly a �world� with 2D backgrounds � it�s just a series of images joined together, and that�s exactly what it feels like when you play through it.
Imagine this for Monkey Island 5, only fully explorable and with everything moving. *Drools*.
3D backgrounds saved as 2D aren�t all that bad though. Escape from Monkey Island may have left a slightly bitter taste in most gamer�s mouths (although the SCUMM Bar looked nice enough inside), but that�s not to say that pre-rendered means shoddy quality. Our very own Goblin shows how 3D and 2D can merge and still look fantastic � just take a look at the art-work on his site to see what I mean. I for one won�t be complaining if Monkey Island 5 ends up looking like that.
There is arguably one advantage 2D has over 3D, however: 2D has more style. Ask Bill Tiller to design a house for you and he�ll most likely do it with wonky sides, probably from a weird perspective or something. Take that design to a builder and have them build that house, and it�ll most likely collapse within a few seconds. I�m sorry, but it�s true. What�s the meaning behind this analogy? Quite simple � in a 3D world, it�s harder to visualise the Monkey Island style. With 2D, you can just draw whatever and that�s that. With 3D, you have to make everything an individual object, so whilst it saves time with animations, it can take much longer with the game environment itself, and this means that developers might be more willing to cut back on style, keeping it sweet and simple for the 3D engine to handle.
Then there�s the specifications battle. Do you really want to have to go out and buy a Pentium 7 with 3 million megabytes of RAM just to play Monkey Island 5? Or do you want to play a good looking � but 2D � version that can run on your 5 year old Pentium 2? The answer, for most of you, is going to be the latter � but in asking this question, I�m assuming that 3D means high specifications, and it doesn�t necessarily have to. Nobs can be twiddled to reduce the number of polygons, making the game look mediocre but still having the all-important 3D ingredient that makes the game more absorbing. Or, like Half-life 2, the game engine can be coded so that it doesn�t depend so much on the specifications.
Converting stuff like this to 3D wouldn�t be easy. It would be a shame if the CMI-esque style was dropped, but maybe the series needs to go more realistic graphic wise anyway.
And speaking of Half-life 2, have you seen those facial expressions!? I have, and when I first saw them in action I remember thinking �ooh, I wouldn�t mind seeing that for Monkey Island 5!�. This is just another benefit of 3D games � they have the power to give realism. Consideration would have to be taken to ensure that the all-important Monkey Island style was not sacrificed to make way for realism, but I believe this can be achieved with a little tender loving care.
So what does 3D mean for Monkey Island? I�ll tell you � it means freedom. It gives designers the ability to do so much more with the characters and the environment than 2D can offer. 2D adventure games won�t die out, though � they�ll live on, used by both the amateur and small developer to save money, but if the big adventure game names like Monkey Island want to keep on the cutting edge of gameplay, then they�ll need to be in real 3D. As simple as that.
Further reading: see what the Tiller man has to say about 3D in our interview with him. Also be sure to read Remzo�s article on the Cel Shading alternative.
As always, be sure to leave your opinion down below!
Next week: Gabez looks at what Sam & Max�s death really means for Monkey Island - has LucasArts killed the adventure game?
Well, perhaps cleaning up the game's graphics would be nice, but they would have to make it more dirty. That was one thing I didn't like about CMI. It was too clean. The pirates should have been dirtier with filthier clother etc.
The CMI graphics ruled! The EMI graphics on the other hand really sucked! I mean, Guybrush'a fingers were like blocks or something! I think that the next MI should follow the CMI graphics in a 3D style (like they tried to do in EMI) but they REALLY have to do something about cleaning up the 3D graphics - add more pollies or something!
"Consideration would have to be taken to ensure that the all-important Monkey Island style was not sacrificed to make way for realism, but I believe this can be achieved with a little tender loving care."
I agree with Remi; I was talking to Jake back when Beyond Good and Evil came out and he was waxing lyrical about how CMI-esque it was. As regards to how you view the 3D world, Gab, perhaps like LBA 2. In this game, the viewpoint was fixed, like CMI, EMI etc - but when you press [enter] it immediately reset the view to directly behind the character. This way you could basically choose which angle you wanted to view the game from, and change it whenever you wanted, with total ease.
The debate of 3D vs 2D is irrelevant if, like EMI, the game is completely devoid of a decent script and any sense of comic timing.
If you get that right, and manage to translate the offbeat a distinctive style of the earlier games then I see no problem in going to 3D. A camera style similar to the N64 Zelda games would be an interesting departure, but at the expense of losing Guybrush's facial expressions.
But the games are more than just graphics, and have to work on all levels, or else (as essentially comedy games), they'll fall flat.
Very good artical, you seemed to have covered all areas well and not only put your side of it down, but look at all angles. You've noted the advantages and disadvantages of both variables and overall, expressed which one, in your opinion, is better and why.
Whilst I don't fully agree with all of your veiws here, I can see where 3D would greatly benifit a potential Monkey Island sequel.
But I do think that a camera fully following you around may not be the best option, it may seem too much like a third person shooter or something. Unless of course you are thinking along the lines of Broken Sword 3, that whilst not the greatest game out of the three (by far) was very innovative in it's sweeping camera moves and changings of angles which I greatly appriciated Overall, I think we all want a good movie in an adventure game, and that includes dynamic veiws and ever changing scenery.
Then again, if all can't be achieved, I won't complain about static backgrounds, just as long as they're done right.
Truthfully, I hated the graphics in Mi4, but no doubt, they needed the change, I'm not saying the graphics in number 3 sucked, I loved them in fact, but the revoloution of gaming graphics are changing rapidly, soon we'll see games where your friends are saying, why are you watching that movie? Anyway, why I hated MI4 graphics so much is because, well look at it, his hair is blocky, same with his hands, Lucas Arts needs to change everything and smooth things out a bit, they may even want help from the graphics team from their Star Wars games, lol just an idea, anyway, hopefully some big changed will happen in the future.
Yeah, the previous games didn't really have particularly impressive animations because there weren't enough frames used in each animation to make it look smooth and beautiful. They are a little jerky - even in CMI.
I am personally fully in support of a totally 3D Monkey Island game. A year or so ago, I was totally against it, but now that the graphical and computational power exists to create something that is extremely realistic, it would work very well.
Take the latest unreal engine for example ( www.thrik.dodnetwork.com/gobble/ue37.jpg ). That thing can output about two million polygons in real time, using cutting edge current technology.
To put that into perspective, an average Half-Life engine based map could only handle roughly nine HUNDRED polygons before starting to choke. All the detail you saw in any Counter-Strike, Half-Life, Day or Defeat or Natural Selection map only came to about 900 polygons on screen. Needless to say, the potential for what can be done with a couple of million is astounding.
I said this over at the GFN once, and I'll say it here - Grim Fandango's 3D pre-rendered graphics could probably be replicated in totally pannable real-time 3D in a couple of years. As in, they'd look AS good.
I personally think that if the technology we'll have at our fingertips in a couple of years, a brilliant art director, and an excellent team of writers were combined, a 5th Monkey Island could be created in real-time 3D with a more realistic style (rather than the comical effect EMI went for) more akin to LeChuck's Revenge. 3D isn't the devil of adventure gaming - it just hasn't been realised for its true potential yet.
I also didn't know about the 2D vs 3D animation thing - that's very interesting. I would still say that EMI had the best animation though, so maybe the previous games didn't take advantage of 2D animation like they could have... I dunno.
Very very good article Gabez (like all your other articles so far).
When I thought adventure games were dead to me, I met a game called Syberia (and now the 2). In my opinion that's a good example of evolution, instead graphics such as EMI. And I agree with with Laur, CMI still is the height of the Monkey Island style.
Between 2d and 3d graphics (all square) such as EMI, I definitely choose the old 2D.
Anybody who don't believe that the MI-feel can be re-created in 3d should check out Beyond Good & Evil. It has the artistic brilliance of CMI, yet technically lightyears more advanced. Other than the obvious advantages to a 3d engine (explorations, dynamic cameras, etc.) you get stuff like night and day which really sets the mood.
The way I imagined it was to have the camera follow Guybrush around, 3rd person shooter style.
Or you could go thr way of the 3D RTS, and have a fix perspective, but the option to rotate your view. Or something else - I dunno, but I reckon it's worth LucasArts experimenting.
And yeah, the grains of sand thing isn't really important, but I think the ability to PROPERLY explore your environment is. I wouldn't mind getting rid of the old map transportation system too - just as long as it doesn't end up like STS 3D.
I'm liking what you're saying Gabez, and you keep making some great points. Since reading your articles, it has become clear to me what the "perfect" adventure game would be, in my eyes. Maybe I'll write it down one day.
As much as little graphical enhancements like tiny grains of sand that fly up as you run are nice, they're not necessary. But, as you say, they *can* be optional. I always find little things like that a nice suprise on console games, but on the PC its usually "oh ffs, this sand is slowing the game down >:" But, as I (and you) have said, it's optional on the PC.
With EMI, the backgrounds were pre-rendered, and the characters were 3D. This was ok, but lets suppose the backgrounds were 3D too. How would the player rotate the game world, so to speak, in order to see the backgrounds from another angle?
Great article, turned my head around about 3D, but ultimately, I side with the 2D.
The MI style,( wacky misproportions) which as you said, wouldn't translate well into 3D, isn't really something I'd be prepared to compromise.


text:
2020-21 Reopening Plans and COVID-19 Resources
Preschool to Grade 8 international school in Mountain View, California
A Mandarin-English dual language, whole child education Preschool to Grade 8 international school in Mt.View, CA
A Mandarin-English dual language, whole child education
About YCIS
YCIS Schools Network
Faculty-Staff Directory
Why Choose YCIS?
YCIS At a Glance
Tours & Open Houses
International Field Trips
Orchestra & Choir
Parent Organization (PO)
Seeds of Hope
Cultivating Global Citizens Who Will Make a Difference in Our Changing World
At the root of our philosophy is the blend of Eastern and Western cultures. At YCIS, we are committed to developing a unique international education. One that is not restricted to a single national curriculum. One that embraces multicultural perspectives and viewpoints. One that cultivates care and compassion and inspires students to make a difference in our ever-changing world.
To raise globally competent and compassionate leaders with a servant's heart, who aspire to, and act for, a better world.
YCIS Silicon Valley's English-Chinese dual language program transforms generations of students into bilingual, compassionate multicultural leaders, exhibiting strong community values and academic excellence.
Founded with the aim of educating students to develop good character and sound knowledge – the two pillars of society – YCIS schools continue to instill strong values and support students in developing a strong moral compass. At YCIS Silicon Valley, we cultivate respect, friendship, creativity, gratitude, humility, generosity, commitment, kindness, patience, peace, and honesty in all we do.
Our Principles and Practices
We believe that the core purpose of education is character formation, and it is the most important shared responsibility of the school and home.
We believe that each child is unique, with innate talents and gifts that should be nurtured to the fullest potential.
We believe that quality student-teacher relationships are at the heart of meaningful engagement, leading to highly effective learning and teaching.
We believe that Learning Communities best enable students and teachers to creatively and holistically explore different fields of knowledge, fostering individual and collaborative learning skills that are critical for the 21st Century.
We believe in equipping our graduates with a deep respect for and understanding of world cultures, mastery of Chinese and English, plus proficiency in other modern languages, as well as a strong commitment to meeting challenges of their generation.
YCIS Hong Kong
YCIS Shanghai
YCIS Beijing
YCIS Chongqing
YCIS Qingdao
YCIS Silicon Valley
©2022 Yew Chung International School of Silicon Valley. All rights reserved. YCIS is a non-profit 501(c)3 school. Legal Information.


text:
Q: Type checking union types Consider the following code:
interface CarData{
   wheels: number
}

interface PlaneData{
   wings: number
}

interface Vehicle{
   type: string,
   data: CarData | PlaneData
}

function printWheels(data: CarData){
   console.log("Number of wheels: " + data.wheels);
}

function printWings(data: PlaneData){
   console.log("Number of wings: " + data.wings);
}

let vehicle: Vehicle;

switch (vehicle.type)
{
    case "car":
        printWheels(vehicle.data);
        break;
    case "plane":
        printWings(vehicle.data);
        break;
}

I get the error Argument of type 'CarData | PlaneData' is not assignable to parameter of type 'CarData'.
  Property 'wheels' is missing in type 'PlaneData' but required in type 'CarData'. which makes sense since it doesn't know what type data is. It can be solved by adding a shared member that tells the type. The following code type checks correctly:
interface CarData
{
    kind: "carData",
    wheels: number
}

interface PlaneData
{
    kind: "planeData",
    wings: number
}

interface Vehicle
{
    type: string,
    data: CarData | PlaneData
}

function printWheels(data: CarData)
{
    console.log("Number of wheels: " + data.wheels);
}

function printWings(data: PlaneData)
{
    console.log("Number of wings: " + data.wings);
}

let vehicle: Vehicle;

switch (vehicle.type)
{
    case "car":
        if (vehicle.data.kind == "carData") printWheels(vehicle.data);
        break;
    case "plane":
        if (vehicle.data.kind == "planeData") printWings(vehicle.data);
        break;
}

But this gives me extra values in data interfaces which I don't like. Is there a more elegant way to do this?

A: You can do a switch directly on the discriminating field and TS will be able to work out that you are calling each function safely
switch (vehicle.data.kind) {
    case "carData":
        // vehicle.data is of type CarData
        printWheels(vehicle.data);
        break;
    case "planeData":
        // vehicle.data is of type PlaneData
        printWings(vehicle.data);
        break;
}

See this TypeScript Playground to see how this works without type errors

redpajama_set_name: RedPajamaStackExchange


text:
Franc Berneker (October 4, 1874 – May 16, 1932) was a 19th- and early-20th-century Slovene tomb sculptor, who had a strong impact on Slovenj Gradec gaining recognition for his work in bronze, marble and monuments. His art focus went from realism to modernism to psychology, drama and an exploration of the relationship between worked and unworked, smooth and rough. He studied with Edmund von Hellmer at the Vienna Academy of Fine Arts and Ivan Zajec on monuments of national heroes His art work is displayed at the Resau Art Nouveau Network.

List of sculptures

Below is a list of some of Berneker's sculptures:

 A Girl
 Gradišče, Slovenj Gradec
 The Drowned Couple
 Oton Župančič
 Drama
 Victims
 Zdenka Vidic and Mira Ban
 Female Head
 Wrestlers
 Monument commemorating Trubar
 Model for Turner's Tomb
 Model for a Monument for Adamič and Lunder.

Exhibitions
Berneker's work has been shown around the world in museums including:

 Belgrade (1912)
 Bled (1911)
 Celje (1940)
 Ljubljana (1902, 1911, 1912, 1913, 1938, 1940)
 London (1906)
 Slovenj Gradec (1984, 2001)
 Trieste (1907)
 Vienna (1904, 2003).

References

1874 births
1932 deaths


Solo and ensemble festival offers instrumental music students the opportunity to perform a solo and/or an ensemble before an expert judge. The judges make verbal and written comments on the students' performances and award ratings from first through fifth division. Medals are given to students who earn a first or second division rating.
The festival will take place on Saturday, November 11th. The festival will be held at Charlotte Middle School. Students who participate in the festival are responsible for their own entry fees and transportation. The entry fee is $12.00 per person per event. The fee for a solo is $12.00, a duet is $24.00 (split between the two players), a trio is $36.00 etc. Entry fees are due by Friday, September 29th.
Students who are studying with a private teacher usually will have their solos chosen by their teacher. East Lansing has appropriate solo and ensemble music for students who are not taking private lessons. This year we are going to bring in Michigan State Community Music Faculty to coach the small ensembles during class.
Please return the form at the bottom of the page by September 29th if your student would like to participate in solo and ensemble festival. Registration fees are due at the same time. Please seal everything in an envelop with the student's name on the front. This festival is optional.


KYLIAN Mbappe and Neymar, who joined for a combined $ 580m, watched on from the stands as Paris Saint-Germain prepared for their Champions League trip to Liverpool with an emphatic 4-0 win over Saint-Etienne in Ligue 1 on Friday.
Verratti's ball over the top found Draxler in the box, with the German midfielder controlling the ball with his head and then nodding it over Saint-Etienne goalkeeper Stephane Ruffier.
PSG's second goal arrived just after half-time, with Cavani converting a penalty, his third goal in as many games this season, after he had been chopped down in the box by Loic Perrin.
Then Diaby rounded off the scoring after Cavani's swipe at a Draxler cutback had turned into an assist for the teenager.
Earlier on Friday, Nice shook off the absence of Mario Balotelli as they came from behind to beat Rennes 2-1 on the Cote d'Azur.
A Malang Sarr own goal had allowed Rennes to take the lead, but Allan Saint-Maximin equalised before Pierre Lees-Melou's 89th-minute winner for Patrick Vieira's side.


Our cloud solutions are as customizable and configurable as possible.
Your hardware, our secure location. A match made in heaven.
Not sure about the Cloud? Let us give you a clear forecast.
In a medical clinic, preservation of our medical records is imperative.
the process much easier and more streamlined.
85under. It's that simple. The 85under facility is very impressive.
very comfortable knowing that our data is safe in 85under.


text:
Home News South bar owners 'treat' loyal customers
South bar owners 'treat' loyal customers
Radhica De Silva
Regular customers enjoy free beers during a happy hour at the Hill Top Restaurant and Bar in Debe yesterday, ahead of today's new COVID-19 lockdown restrictions which will prevent consumption of alcohol at bars.
As the hour drew closer for the new phase of COVID-19 restrictions to kick in, bar owners in South Trinidad gave free beers and cutters to loyal patrons.
Rather than allowing stocks to expire as they did during the last three-month lockdown, the bar owners said they wanted to show appreciation to loyal customers in the hope that they will return to buy once the new restrictions take effect today.
At the Hill Top Restaurant and Bar, along the SS Erin Road, over a dozen patrons were seen enjoying free beers when Guardian Media visited yesterday.
Owner Vishnu Ramraj said although bars will be allowed to stay open for takeaway service, this would still lead to a loss of income.
"We know that people will go to the supermarket to get their drinks rather than come to the bar, so instead of stocks wasting away like the last time, we are giving a happy hour. Free drinks for our loyal customers," Ramraj said.
He added that the bar drinkers also made a big cook to celebrate the last time they will be allowed to congregate together.
Bar manager Farida Lalchan agreed that many bar owners will have no choice but to shut down.
She said, "We have rent to pay and I feel that many bar owners have been responsible for maintaining social distancing and ensuring the place is clean. They could have allowed people to continue to operate.
"As it is, I have no plans in place to deal with the loss of income. I don't know what I would do."
Patron Andre Manoo said most people would prefer to buy beers in a supermarket rather than a bar if they are denied the opportunity of sitting down to enjoy the drink.
"It cost $7 for a beer from the supermarket and $10 in the bar. If you have to buy and go, people will go to a supermarket rather than a bar," Manoo said.
At Bomb Scare restaurant and bar, Rachel "Dumpling" Lalchan said she was not in support of the new COVID-19 regulations. She said although Prime Minister Dr Keith Rowley had said bars could open, there would be no point in staying open if nobody comes to buy.
"I think lots more workers will be on the breadline. We think that they could have reduced hours," she said.
She said because they expected a large turnout of patrons coming to the bar yesterday, she made a big cook.
"We did some curried duck and chicken and a whole lot of cutters. We are giving away the cutters for free," she said.
Meanwhile, there continued to be an outpouring of patrons at several other bars.
Along the Southern Main Road in Rousillac, Frazina's Bar was overflowing with people. Loud music blared from the speakers. There was a similar scene at Ralphie's Bar in Oropouche. Other bars such as Rumedy and Limelight Restaurant and Bar, as well as Mano's Restaurant and Bar, also had a healthy flow of customers.
During the last lockdown, many bar owners complained that their stocks expired and they suffered losses because of their forced closure. At the time, many operators called for bars to stay open and offer takeaway service.
In July, over 316 bar owners and operators were given the green light to sue the State over a recent move to reduce the opening hours for their businesses under ongoing COVID-19 public health regulations. Lawyers representing the Barkeepers and Operators Association of T&T (BOATT) and 316 of its members filed the judicial review lawsuit before Justice Avason Quinlan-Williams. Days later, the claim was partially withdrawn after lawyer Anand Ramlogan, SC, indicated that his clients would no longer be pursuing the judicial review aspect of the case because of the Government's move to allow bars to close at 10 pm.
Previous articleSoutherners brave weather for 'last' beach day
Next articleParents grateful SEA exam still on


text:
Moyes 'hurt' by Cats
David Moyes. Pic: PA
Sunderland boss David Moyes admits his pride has been hurt by his ongoing battle to rescue a club which has "forgotten how to win".
The 54-year-old Scot could suffer the ignominy of taking the club down to the Sky Bet Championship after a decade in the Premier League if they lose to Bournemouth today, with fans in open revolt as a traumatic season approaches a seemingly inevitable conclusion.
He said: "Oh, it hurts me, it hurts me totally. I'm certainly not smiling and laughing and enjoying myself. You want to have a winning feeling. Maybe we've forgotten how to do that.
"We have forgotten how to win. We have got to find that and we have got to get it back quickly."
For all Moyes is currently bearing the brunt of mounting frustration on Wearside, he inherited many of the problems he is currently facing with toxic debts making for a bleak financial picture.
However, he insists he has the appetite to see it through and has no intention of walking away. He said: "I'm here, I'm doing the job, I'll be working as hard as I can preparing the players to try to win tomorrow. We need to win tomorrow. We don't want to go down, but we also want to build momentum."


text:
Catalogue » Rail » The GWR Exposed
The GWR Exposed
Swindon in the Days of Collett and Hawksworth
At the Grouping of Britain's railways in 1923 the Great Western Railway had an advantage over the other Big Four railway companies in that it retained essentially the same management structure that it had had pre-Grouping. Yet the next 25 years were arguably characterised by a series of mistakes in its engine building policy as the advances made by the other companies were largely ignored. This controversial new history of the GWR examines the role and policy of the two Chief Mechanical Engineers at the GWR in this period - Charles Collett (1922-41) and Frederick Hawksworth (1941-7) - following the legacy of the often pioneering work of the previous CME, George Churchward (1902-22). Collett had spent his entire working life at the GWR and his autocratic and introverted nature did not encourage innovation or outside influence. With little experience of the operational demands on the fleet, the long-term strategy of the engine building policy was neglected, as were the opportunities for efficiencies through standardisation. Stanier was a talented engineer at the GWR but moved to the LMS in 1932 and when Hawksworth took over from Collett, having worked many years under his shadow, the narrowness of his experience was a severe handicap. The constraints of the war gave him little opportunity to reinvigorate the company and improve its operating efficiency to match that of its rivals as his power and influence waned and he achieved little before the company was subsumed into the nationalised railway in 1948. This enlightening history brings a whole new focus to GWR history and will be fascinating reading for all enthusiasts of the railway and for more general readers.
Dimensions: 21.1 x 2 x 26.6 cm


Enhancing your presence on the internet is important, regardless of what industry you are in or how large your organization is. However, it can be difficult to know how to get started when it comes to website design. The tough and always changing nature of web design implies that creating a website for your company really should only be attempted by somebody with the required experience. In line with a greater need for good quality websites, an increase in the number of businesses offering these professional services has in turn risen. Exactly how do you know who to choose for a professional Merced web design company? To make the decision easier, we have outlined a few of the factors to bear in mind when selecting a web design firm.
By getting in touch with several web designers in Merced prior to making a decision, you have a better idea of what is available to you. It is also crucial that you ask for quotes, as prices may differ.
Your site can't only look nice, but it also needs to work correctly on a variety of mobile device sizes, meaning you will need to look for a responsive web design company to ensure this is the case.
Look for a business offering Merced web design services that doesn't only have a background in graphics and advertising, but also a solid background in coding and web development so they can create your site wisely, error-free, and compatible with all the major web-browsers on the internet.
Search engine optimization (SEO) is extremely essential for directing traffic to your site – ensure that the mobile web design company in Merced you select offers these services.
Ask for an estimate of just how long site construction will require, so you've an idea of when your website will go live. If you are in a hurry to get your site up, you'll pay a premium rate for this.
With years of experience on dozens of websites, we are Merced web designers who are unparalleled. We will address the items above and to be sure you receive the best final result for your business and website visitors, we can also assure the following services.
We provide testimonials from our past customers so that you know exactly what you should expect from us.
With your business goals and objectives as our main priority, our company providing web design in Merced, CA will do whatever needs doing to make sure they are met.
We know you are keen to have your website ready to go as quickly as possible and will do whatever we can to ensure this happens.
Lastly, keep in mind that we were able to reach you right now via your own internet search. Our understanding of connecting clients to online services by using SEO makes us the right choice for your company. Wouldn't you like more prospective customers in your area to find you by means of their internet searches? Call us today to discuss alternatives for your company, or simply fill in the form located above. You can also get our case study on the redesign of the site for a local cleaning company and the amazing increase in free organic search traffic that resulted. Get it here.


text:
MAKEFLAGS = -j1

export NODE_ENV = test

# Fix color output until TravisCI fixes https://github.com/travis-ci/travis-ci/issues/7967
export FORCE_COLOR = true

.PHONY: build build-only build-dist watch \
  docs-clone docs-build docs-clean \
  lint fix lint-package lint-staged \
  clean test-clean clean-all \
  test-only test-cover test test-ci test-build \
  precommit prepush publish bootstrap bootstrap-ci

build: build-only

build-only:
	./node_modules/.bin/gulp build

build-dist: clean build

docs-clean:
	rm -rf docs

docs-clone: docs-clean
	git clone -b gh-pages https://github.com/remotelib/remote-lib.git docs

docs-build:
	test -d "./docs" || make docs-clone
	./node_modules/.bin/esdoc

docs-publish:
	test -d "./docs/.git" || make docs-clone
	make docs-build
	cd ./docs && \
	git add . && \
	git commit -m `cd .. && git rev-parse HEAD` && \
	git push
	open http://www.remotelib.com/

watch: clean
	BABEL_ENV=development ./node_modules/.bin/gulp watch

lint: lint-package
	./node_modules/.bin/eslint scripts test packages *.js --format=codeframe

fix:
	./node_modules/.bin/eslint scripts test packages *.js --format=codeframe --fix

lint-package:
	./scripts/lint-package.sh

lint-staged:
	./node_modules/.bin/lint-staged

clean: test-clean docs-clean
	rm -rf packages/*/lib
	rm -rf packages/*/npm-debug*

test-clean:
	rm -rf packages/*/test/tmp
	rm -rf coverage

clean-all: clean
	rm -rf node_modules
	rm -rf packages/*/node_modules

test-only:
	./node_modules/.bin/mocha "packages/*/test/*.js"
	make test-clean

test-cover:
	node_modules/.bin/babel-node node_modules/.bin/istanbul cover ./node_modules/mocha/bin/_mocha "packages/*/test/*.js" --check-coverage --report lcovonly -- -R spec

test-build: build-only test-only

test: lint test-only

precommit: lint-package lint-staged

prepush: clean test-build

test-ci: lint test-cover
	codecov
	make test-clean

publish:
	git pull --rebase
	rm -rf packages/*/lib
	make build-dist
	make test
	./node_modules/.bin/lerna publish --conventional-commits
	make docs-publish

bootstrap: clean-all
	npm install
	./node_modules/.bin/lerna bootstrap -- --no-package-lock
	make build-dist

bootstrap-ci: bootstrap
	npm install -g codecov

redpajama_set_name: RedPajamaGithub


The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an increased risk of CRC. The dietary effects may be modulated by genetic polymorphisms in biotransformation genes. In this study we aimed to evaluate the role of dietary factors in combination with genetic factors in the different stages of colorectal carcinogenesis in a Norwegian population.
We used a case-control study design (234 carcinomas, 229 high-risk adenomas, 762 low-risk adenomas and 400 controls) to test the association between dietary factors (meat versus fruit, berries and vegetables) genetic polymorphisms in biotransformation genes (GSTM1, GSTT1, GSTP1 Ile105Val, EPHX1 Tyr113His and EPHX1 His139Arg), and risk of colorectal carcinomas and adenomas. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by binary logistic regression.
A higher ratio of total meat to total fruit, berry and vegetable intake was positively associated with both high and low-risk adenomas, with approximately twice the higher risk in the 2nd quartile compared to the lowest quartile. For the high-risk adenomas this positive association was more obvious for the common allele (Tyr allele) of the EPHX1 codon 113 polymorphism. An association was also observed for the EPHX1 codon 113 polymorphism in the low-risk adenomas, although not as obvious.
Although, the majority of the comparison groups are not significant, our results suggest an increased risk of colorectal adenomas in individuals for some of the higher ratios of total meat to total fruit, berry and vegetable intake. In addition the study supports the notion that the biotransformation enzymes GSTM1, GSTP1 and EPHX1 may modify the effect of dietary factors on the risk of developing colorectal carcinoma and adenoma.
Colorectal cancer (CRC) is one of the most prevalent diseases in the industrialized Western countries. In Norway, with one of the highest incidence rates in the world, approximately 3500 new cases of CRC are diagnosed every year .
Epidemiological studies have attributed more than 85% of CRCs to environmental factors [2, 3], particularly dietary factors . Diets high in red meat and fat and low in fruit and vegetables are associated with an increased risk of CRC [5, 6]. Although not entirely consistent, results from case-control and cohort studies suggest a modest association between intake of red meat and risk of CRC [7–9]. The mechanism behind the specific risk-enhancing effect of red meat is not precisely known, but there is evidence suggesting that components of red meat may independently increase the risk of CRC . It has also been suggested that any association between high meat consumption and CRC may be a result of deficiencies in other protective dietary factors, such as fruit and vegetables [11, 12]. In contrast to earlier studies, more recent epidemiological studies have generally not supported a strong influence of dietary fiber or fruit and vegetables, although these have other health benefits . This has led to the notion that it is the ratio between meat and fruit/vegetable intake that is important. A study by Kapiszewska  showed that both the ratio between vegetables and meat consumption, as well as the ratio between the amount of energy from vegetables and animal products, can be used successfully to evaluate the relation of dietary pattern to cancer risk.
It is widely known that humans differ in their susceptibility to cancer. Difference in carcinogen metabolism might explain the differences in cancer susceptibility especially as most cancers are influenced by environmental factors . Dietary effects might be modulated by genetic polymorphisms in biotransformation genes . In the biotransformation system there are several interesting genes including microsomal epoxide hydrolase (EPHX1) (phase I) and gluthatione S-transferases (GSTs) (phase II), all with known polymorphisms [16, 17].
The EPHX1 gene has a dual function and catalyzes the hydrolysis of arene, alkene and aliphatic epoxides to less reactive and more water-soluble dihydrodiols, but activates some polycyclic aromatic hydrocarbons into a more carcinogenic form . A tyrosine to histidine substitution in exon 3 (Tyr113His) of the EPHX1 gene decreases in vitro enzyme activity by 40%, whereas a histidine to arginine substitution in exon 4 (His139Arg) increases in vitro enzyme activity by 25% .
GSTs are responsible for the glutathione conjugation and detoxify a number of various reactive species . Genetic polymorphisms that result in reduced or absent activity or expression of the GST enzyme are known for most GST isoforms . Research has mostly focused on the GSTM1 and GSTT1 deletion polymorphisms ("null" genotypes) resulting in absence of the GST μ1 and GST μl enzymes , and the GSTP1 Ile105Val polymorphism resulting in a less active enzyme .
Several lines of evidence support the adenoma – carcinoma sequence as the major path for colorectal carcinogenesis. The present study aimed to investigate the role of dietary factors (meat and fruit/vegetables) in combination with genetic factors in the different stages of colorectal carcinogenesis in a Norwegian population.
The KAM cohort (Kolorektal cancer, Arv og Miljø) is based on the screening group of the Norwegian Colorectal Cancer Prevention study (The NORCCAP study) in the county of Telemark , and a series of clinical CRC cases (mean age 67.3, SD 11.2) operated on at Telemark Hospital (Skien) and Ulleval University Hospital (Oslo). Those invited to participate in the NORCCAP study were 20,780 men and women, age 50–64 years old, drawn by randomization from the population registry in Oslo (urban) and the county of Telemark (mixed urban and rural). They were invited to have a flexible sigmoidoscopy screening examination with or without (1:1) an additional faecal occult blood test (FOBT). Seven hundred and seventy-seven individuals were excluded according to exclusion criteria. The overall attendance rate was 65%. The ID number for the NORCCAP study at ClinicalTrials.gov is I NCT00119912 . The screened cases in the NORCCAP study selected for colonoscopy were invited to participate in the KAM study (1044 cases agreed). During a limited period of time, after the screening study of NORCCAP was well established, controls (polyp free by flexible sigmoidoscopy) were invited to participate in the KAM study (400 controls agreed). The KAM cohort is based on an ethnic homogenous group of Norwegian origin. Written consent was obtained from all the participants. The KAM study is approved by the Regional Ethics Committee and the Data Inspectorate.
The KAM biobank consists of blood and tissue samples from 234 CRC cases (16 identified in the NORCCAP screening group and 218 from hospitals), 1044 individuals identified with polyps in the large intestine (229 high-risk and 762 low-risk adenomas, 53 hyperplastic polyps) and 400 controls, defined as individuals with normal findings at flexible sigmoidoscopy screening. Adenoma cases and controls were all drawn from the NORCCAP study. All of the participants completed a questionnaire on demographics, health status, dietary and smoking habits, alcohol consumption, physical exercise and occupation. The questionnaire contained information on a family history of adenomas and carcinomas, and the cases and controls included had no known personal history of genetic predisposition.
Diet was assessed in cases and controls using an extensive diet and lifestyle questionnaire, modeled on a questionnaire developed and validated for an American breast cancer study [26–28]. It was designed in a food frequency manner, asking the participants to record their average consumption, during the last year, of a wide range of typically Norwegian food items by ticking off fixed frequency and portion size boxes. Nine frequency choices, ranging from "never/less than once per month" to "2 or more per day" were given, whereas portion size was recorded as small, medium or large. The medium portion size was defined in the questionnaire (e.g. units, grams, dl). A small portion was defined as half or less than half of the medium portion, and a large portion was defined as one and a half or more of the medium portion. All questionnaires were checked for mistakes and completeness, and the participants who had delivered an inadequate questionnaire were contacted by phone in order to improve the quality of the data.
The adenocarcinomas were collected prior to chemo- or radiotherapy treatment. Two specialists in histopathology examined the histology of the adenomas independently in order to determine the tumor stage as mild, moderate or severe dysplasia. They reached the same conclusion in all cases.
Diminished numbers of available cases in the KAM biobank and analyzed cases are due to loss of samples during preparation and/or lack of information from the questionnaires. The 53 hyperplastic polyps were not included in the present analysis. A high-risk adenoma was defined as an adenoma measuring = 10 mm in diameter and/or with villous components and/or showing severe dysplasia .
Genomic DNA was isolated from blood samples according to standard procedures  with minor modifications as previously described .
Polymorphisms of the GSTM1 (null), GSTT1 (null) and GSTP1 (Ile105Val) genes were analyzed simultaneously by multiplex PCR as described by Nedelcheva Kristensen et al..
The EPHX1 His139Arg polymorphism (rs2234922) was analyzed by a PCR-RFLP (restriction fragment length polymorphism) method as described by Hasset et al..
Genotype analysis of the EPHX1 Tyr113His polymorphism (rs1051740) was carried out using the TaqMan allelic discrimination assay on a Sequence Detection System ABI 7000 (Applied Biosystems), using the primers forward: 5'-TCT CCT ACT GGC GGA ATG AAT T-3', reverse: 5'-CTG GCT GGC GTT TTG CA-3' and the probes T-allele: 5'-VIC-TCT CAA CAG ATA CCC TCA-MGB-3', C-allele: 5'-6-FAM-TCA ACA GAC ACC CTC A-MGB-3'. The polymorphism was determined in a 12 μl reaction containing 1× MasterMix, 200 nM of each probe, 900 nM primers, and ca 50 ng of genomic DNA. Cycling conditions were as follows: 50°C for 2 min, 95°C for 10 min, and 45 cycles of 95°C for 15 s and 60°C for 1 min. Controls were included in each run, and 10% of the samples were retyped with identical results.
Eight summary variables were created from the individual dietary items in the food frequency questionnaire to describe the intake of red meat, processed meat, total meat, raw vegetables, boiled vegetables, fruit and berries, total fruit, berries and vegetables and the ratio between total meat and fruit, berry and vegetable intake. For each individual dietary factor, the frequency and portion size were multiplied to obtain the amount in grams per day. The summary variables were then divided into quartiles based on distribution of consumption among controls.
Differences in characteristics between the control group and all the case groups were assessed using the χ2 test for categorical variables and the Mann-Whitney test for continuous variables. P-values < 0.05 were considered significant. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using binary logistic regression analysis to assess the relationship between the dietary factors, each polymorphism and colorectal carcinoma or adenoma cases. Crude ORs were calculated, adjusted for age and gender only. In addition multiple logistic regression analyses were performed with an adjustment for age, gender, smoking dose, alcohol consumption, and when appropriate total meat consumption and total fruit, berry and vegetable consumption. In addition the modifying effect by genotype on dietary exposure (ratio of total meat to total fruit, berry and vegetable intake) was studied by stratification in a two by four table. All analyses were carried out using the statistical analysis software SPSS (Chicago, Illinois, USA) 12.0.1 for Windows.
Selected characteristics of cases and controls are shown in Table 1. The gender distribution was dissimilar in the control and the case groups. Cases were older and more often smokers. The low-risk adenoma cases had a higher alcohol intake than the controls. Low-risk adenoma cases had a higher total meat intake than controls, and the high and low-risk adenoma cases had a higher ratio of intake of total meat to total fruit, berries and vegetables.
a There are significant differences in the number of males and females between the control group and all the case groups, P < 10-4.
b There are significant differences in age between the control group and all the case groups, P < 10-4.
c There are significant differences in number of cigarette years (smoking dose) between the control group and all of the case groups, P = 0.001, P < 10-4 and P < 10-4, respectively.
d There is significant difference in number of alcohol units per month between the control group and the low-risk adenoma group, P = 0.013.
e There is significant difference in processed meat consumption (g/day) between the control group and the low-risk adenoma group, P = 0.041.
f There is significant difference in total meat consumption (g/day) between the control group and the low-risk adenoma group, P = 0.027.
g There is significant difference in boiled vegetable consumption (g/day) between the control group and the low-risk adenoma group, P = 0.035.
h There are significant differences in fruit and berry consumption (g/day) between the control group and the carcinoma and low-risk adenoma groups, P = 0.019 and P = 0.005, respectively.
i There are significant differences in ratio of total meat to total fruit, berry and vegetable intake between the control group and the high- and low-risk adenoma groups, P = 0.035 and P = 0.003, respectively.
Missing values for cigarette smoking, alcohol consumption and dietary factors gave rise to diminished number of cases and controls.
The distribution of consumption of the dietary factors in quartiles is presented in Table 2, and the genotype distribution is shown in Table 3. The tables also present the estimates of ORs of colorectal carcinomas and adenomas associated with the various dietary factors and polymorphisms. The tables present only data from the multi-adjusted model which may be a better choice than the crude model in reducing potential confounding in the data.
a Adjusted for age, gender, smoking dose and alcohol consumption. In addition 'Total meat' and 'Total fruit, berry and vegetable' are mutually adjusted for when assessing their main effect. These variables were not adjusted for when the ratio between them was assessed.
b Quantities are gram per day. Categories based on quartiles. Numbers vary between the dietary factors due to missing dietary data.
ref: served as reference category.
a Adjusted for age, gender, smoking dose, alcohol consumption, and the consumption of total meat and total fruit, berry and vegetable.
b Numbers vary between analyzed genotypes due to missing samples and/or failed analysis.
ref: the genotype served as reference category.
No significant trends were observed in the data of Table 2. Total meat consumption showed a borderline significant association with low-risk adenomas in the 3rd quartile, OR of 1.57 (95% CI 1.00–2.46). No significant results were observed for total fruit, berry and vegetable consumption. The ratio of total meat to total fruit, berry and vegetable intake was positively associated with both high and low-risk adenomas in the 2nd quartile (and 3rd quartile for low-risk adenomas) with approximately twice the higher risk compared to the lowest quartile (ORs of 2.59 (95% CI 1.31–5.14) and 1.73 (95% CI 1.08–2.75), respectively). We have also tested the dietary exposures as binary variables, but these results gave less information than the chosen model (data not shown).
The frequencies for the GSTM1 null allele, GSTT1 null allele, GSTP1 105Val allele, EPHX1 113His allele and EPHX1 139Arg allele among the controls were respectively, 0.52, 0.13, 0.37, 0.32 and 0.21 (Table 3). The genotype distributions were all in Hardy-Weinberg equilibrium and the distributions of the alleles are in agreement with those found in other Caucasian populations [32–34]. No significant associations were found between the GST polymorphisms and risk of colorectal carcinomas and adenomas. The EPHX1 113His allele was associated with a decreased risk in low-risk adenomas with OR of 0.67 (95% CI 0.49–0.92), Ptrend = 0.01. No significant associations were seen between the EPHX1 139Arg allele and carcinomas and adenomas. Since the strongest association seems to be with the Arg/Arg genotype we have compared this genotype with the combined His/His and His/Arg genotypes as a reference. The Arg/Arg genotype was associated with decreased risk of low-risk adenomas only, OR of 0.48 (95% CI 0.23–0.98) (data not shown). We have also tested the combined effect of the two polymorphisms in EPHX1 (i.e., Tyr113His and His139Arg). Predicted mEPHX activities were classified as normal, fast and slow . The same tendency was observed as for the separate genotypes (data not shown).
Table 4 display the results from analyses of the effect of the ratio of total meat to total fruit, berry and vegetable intake on the risk of colorectal carcinomas and adenomas stratified by genotype. The case groups are stratified based on polymorphic status, in most common allele or any polymorphic allele. Only data from the multi-adjusted model is presented.
a OR adjusted for age, gender, smoking dose and alcohol consumption.
b Quartiles of ratio of total meat to total fruit, berry and vegetable intake, per day: ≤ 0.19, >0.19 and ≤ 0.38, > 0.38 and ≤ 0.71, > 0.71.
ref: The combination served as a reference.
No significant trends were observed. For carcinomas we did not find any significant association with ratio of total meat to total fruit, berry and vegetable intake, and the combination with genotype gives few significant results. A reduced risk (Q4) was observed in individuals with the GSTP1 codon 105 variant allele (Val allele). In addition a positive association between ratio (Q2) and CRC risk was more obvious in individuals with the EPHX1 codon 139 common allele (His allele).
A higher ratio of total meat to total fruit, berry and vegetable intake was positively associated with colorectal adenomas. For the high-risk adenomas this positive association was more obvious for the common allele (Tyr allele) of the EPHX1 codon 113 polymorphism. The same was seen for the EPHX1 codon 113 polymorphism in the low-risk adenomas, although not so obvious. The ratio (Q2) was also associated with an increased risk of high-risk and low-risk adenomas in individuals with the GSTM1 common allele and the GSTP1 codon 105 variant allele (Val allele).
Statistical analysis of the modifying effect by the GSTT1 polymorphism on the ratio of total meat to total fruit, berries and vegetables intake was not possible to perform due to low sample size.
Sporadic CRC is a consequence of multiple risk factors, among which the interaction between environmental and genetic factors is of particular interest. In this case-control study we investigated whether the consumption of meat and fruit, berries and vegetables or selected genotypes was associated with risk of developing colorectal carcinomas and adenomas alone or if the genotypes could modify the results.
We found only a weak positive association between total meat consumption and low-risk adenomas. Lack of significant association with the cancer group and the high-risk adenoma group, may be due to small sample size. There appears to be consistent evidence from epidemiological data that intake of red meat is positively related to risk of developing CRC [8, 9]. Enhanced risk of colorectal adenomas, an established precursor lesion of CRC, has also been associated with high levels of red meat consumption in some studies [36, 37] but not in others [38, 39].
We did not detect any association between fruit, berry and vegetable intake and risk of developing colorectal carcinomas or adenomas. The association between fruit and vegetables consumption has not been consistently proven in other studies. The majority of case-control studies show an inverse association between intake of vegetables and colon cancer risk, while prospective studies show no association . Distribution of meat, vegetable, fruit and berry consumption in our study is in agreement with the NORKOST survey, a nation-wide survey of a representative sample of the adult population in Norway .
The ratio between total meat and total fruit, berry and vegetable intake yielded an increased risk of high and low-risk adenomas for the 2nd quartile (and also the 3rd quartile for low-risk adenomas) compared to the lower quartile. This result may apply to the general Norwegian population which has little variation in intake of meat, fruit, berries and vegetables. The result is in agreement with the result of Turner et al. who showed that subjects who consumed small amounts of fruit and vegetables per month and many servings of red meat were at greater risk of CRC. The results also support the hypothesis of Kapiszewska  who has argued that it is not the consumption of a single food product or an individual component of diet, but rather a proper ratio of vegetables to meat consumption that contributes to cancer prevention. Lack of balance between the amount of meat and fruit, berries and vegetables may lead to the accumulation of damaged DNA, initiating DNA instability and inducing cancer development.
The GSTM1, GSTT1 and GSTP1 polymorphisms were not associated with risk of colorectal carcinomas and adenomas in this study. This is consistent with the results in some studies [33, 43], but only partly in others .
The EPHX1 113His allele was associated with a decreased risk of low-risk adenomas. The EPHX1 codon 139 polymorphism was not associated with risk of carcinomas and adenomas in this study. Contradictory data have been provided by different studies investigating the EPHX1 codon 113 and EPHX1 codon 139 polymorphisms in relation to the risk of colorectal carcinomas and adenomas [45–50].
There is conflicting evidence regarding the role of GST and EPHX1 polymorphisms in CRC susceptibility. Since the enzymes have detoxifying activity, it would be expected that, rather than affecting the risk of cancer per se, they would modify risk when exposed to potential carcinogens .
To evaluate if the genetic polymorphisms in GST and EPHX1 modify colorectal carcinoma and adenoma risk in relation to ratio of total meat to total fruit, berry and vegetable intake, we stratified the case groups based on the most common allele or any polymorphic allele.
The most convincing evidence of a modifying effect by genotype on dietary exposure was found between EPHX1 codon 113 in adenomas and EPHX1 codon 139 in carcinomas. In our study, for both the EPHX1 codon 113 and EPHX1 codon 139 polymorphisms, the increased risk associated with a higher ratio of total meat to total fruit, berries and vegetables was confined to individuals homozygous for the most common alleles (EPHX1 113Tyr allele and EPHX1 139His allele). To our knowledge no studies have been published on the association between GST and EPHX1 polymorphisms and the ratio of total meat to total fruit, berry and vegetable intake, but some studies have looked at the gene-diet interaction with meat and fruit/vegetables separately. There are few reports on the association between EPHX1 polymorphisms and dietary factors. Cortessis et al. reported increased risk of adenomas in individuals who ate their meat well done and had a high predicted EPHX1 activity (combination with 3 or 4 of the more stable alleles, defined as the Y (tyrosine) variant at exon 3 and the R (arginine) variant at exon 4), whereas Ulrich et al. reported elevated adenoma risks associated with low predicted activity in those with high intake of cooked meat. Other reports on EPHX1 and CRC and adenomas did not find evidence for an interaction with meat intake [42, 47, 48, 50]. One report has suggested a weak interaction between fruit consumption and the EPHX1 113Tyr allele (common allele) , but due to unusual allele frequencies and unexpected pattern of results (greatest risk reduction in the intermediate genotype group) this finding must be interpreted with caution. The biochemical pathways in which EPHX1 participates involve numerous enzymes. The role of EPHX1 itself maybe quite complex, as the enzyme has broad substrate specificity and tissue distribution. Expression of EPHX1 is both induced and inhibited by exogenous compounds . While EPHX1 usually results in detoxification of xenobiotic substances, it is also involved in the metabolic activation of polycyclic aromatic hydrocarbons found in cooked meat, triggering the formation of highly reactive metabolites that can damage DNA, RNA and protein components [35, 53]. EPHX1 activity may also be modulated by components in fruit and vegetables. It is likely that EPHX1 could modify the association between diet and colorectal carcinoma and adenoma risk.
In addition we found weak evidence of a modifying effect by the GSTP1 and GSTM1 genotypes on the ratio of total meat to total fruit, berry and vegetable intake in adenomas. The increased risk associated with a higher ratio of total meat to total fruit, berries and vegetables is restricted to individuals with the GSTP1 codon 105 variant allele (Val allele), and to the GSTM1 common allele. Since there are no significant trends and only a few significant single results caution is required in interpretation of our findings.
Studies have shown that higher levels of DNA damage are associated with the GSTM1/T1 null genotypes and the GSTP1 105Val allele [54, 55]. The higher adenoma risk with a low capacity GST variant could directly reflect the slower processing of genotoxic compounds associated with meat intake. In addition a high ratio of meat to fruit, berries and vegetables may increase the risk of carcinogenesis.
Isothiocyanates (component of fruit and vegetables) are substrates for GSTs [56–58] and thus GSTs contribute to the excretion of isothiocyanates. The involvement of GSTs in isothiocyanate metabolism has led to the hypothesis that, through slower excretion of isothiocyanates from the body in individuals with genetic variants associated with lower GST capacity, isothiocyanates have greater opportunity to exert their chemo-protective effects in these individuals .
As with any case-control study, there is a possibility of bias in recall of diet leading to spurious associations. But for the assessment of gene-environment interactions this is not an issue, since there is no corresponding risk of bias in relation to genotype. We cannot exclude the possibility that the associations may be confounded or modified by other genetic or dietary factors. The CRC cases and controls have not been matched by age, which may affect the results in our study. However, the controls were recruited from the same population as the adenoma and carcinoma cases. Further, our controls have been screened and found polyp free by flexible sigmoidoscopy and the risk of any of them having colon cancer at the time of inclusion is not very likely. It has been estimated that less than 3% of individuals with no adenoma at flexible sigmoidoscopy are likely to harbor an undiagnosed proximal advanced colorectal neoplasia .
Due to the high number of multiple tests and comparisons in the present study, some statistically significant associations have undoubtedly occurred by chance, and caution is required in their interpretation. The results thus need to be verified by further studies with particular focus on the ratio between meat and fruit, berry and vegetable intake and the possible modifying effects of biotransformation genes.
Although, the majority of the comparison groups are not significant, our results suggest an increased risk of colorectal adenomas in individuals for some of the higher ratio of total meat to total fruit, berry and vegetable intake. An unbalanced consumption of meat and fruit, berries and vegetables may lead to accumulation of DNA damage and thus increased risk of cancer development. In addition the study supports the notion that the biotransformation enzymes GSTM1, GSTP1 and EPHX1 may modify the effect of dietary factors on the risk of developing colorectal carcinoma and adenoma.
Camilla F Skjelbred, Mona Sæbø contributed equally to this work.
This study was supported by the Norwegian Cancer Society (Grant numbers 51024/001 and E01-0851001), Telemark University College (Grant number 22069), the Norwegian Colorectal Cancer Prevention (NORCCAP) study (Grants from the Norwegian Cancer Society and the Department of Health and Social Affairs), with the aid of EXTRA funds from the Norwegian Foundation for Health and Rehabilitation (2001/2/0110), Eastern Norway Regional Health Authority.
We thank Dr. Gunter Bock and Dr. Egil Johnson for collecting tumor tissues, Dr. Steinar Aase and Dr. Inger Marie B. Lothe for contributing to the pathology of the cancer cases and Thor Arne Haukedal, Thomas Bekkevold, Lene Løkås and Hege Storheil for technical assistance.
CFS prepared the first draft of the paper. She prepared, with contribution from MS, the dietary data for statistical analysis. She did the data analysis and participated in genotyping of the samples. MS also contributed to the manuscript and with advice in the data analysis, and she participated in genotyping of the samples. AH advised on handling of the dietary data and statistical analysis. GH together with TG and KMT were responsible for designing and administering the NORCCAP clinical trial. In addition GH and TG provided advice on the statistical analysis. ILH participated in collection and quality control of the questionnaires. EHK initiated the KAM study and also organized it. She contributed with advice on data analysis and was responsible for the revisions of the manuscript. All authors discussed the results, contributed to interpretation of the results and the final manuscript.


text:
Anchitosia queenslandensis är en sjöstjärneart som först beskrevs av Livingstone 1932.  Anchitosia queenslandensis ingår i släktet Anchitosia och familjen ledsjöstjärnor.

Artens utbredningsområde är Nya Kaledonien. Inga underarter finns listade i Catalogue of Life.

Källor

Ledsjöstjärnor
queenslandensis


text:
Diop Tehuti Djed-Hotep Spence (Londres, Inglaterra, 9 de agosto de 2000) es un futbolista británico que juega como defensa en el Stade Rennais F. C. de la Ligue 1.

Vida personal
Es el hermano menor de la actriz Karla-Simone Spence. Es de ascendencia keniana y jamaicana.

Trayectoria

Middlesbrough F. C.
Fichado por el Middlesbrough F. C. el 1 de julio de 2018, habiendo estado previamente en la academia del Fulham. Debutó en la Copa de la Liga el 14 de agosto, apareciendo como suplente frente al Notts County F. C. en el Estadio de Riverside. Debutó en liga en la victoria por 1-0 ante el Charlton Athletic el 7 de diciembre de 2019, y marcó su primer gol en liga en la victoria por 1-0 ante el Huddersfield Town el 26 de ese mismo mes.

El 11 de enero de 2020 ganó el premio al Jugador Joven del Mes de la EFL, tras su debut en la liga, su primer gol y sus tres partidos sin goles.

Nottingham Forest (préstamo)
El 1 de septiembre de 2021 se anunció que se uniría al Nottingham Forest F. C. en calidad de cedido por el resto de la temporada. Marcó su primer gol con el Forest en la victoria por 3-0 contra el Birmingham City F. C. el 2 de octubre. Impresionó en las victorias de la FA Cup frente a los clubes de la Premier League, el Arsenal F. C. y el Leicester City F. C., marcando el cuarto en la victoria por 4-1 sobre este último, que le relacionaron con un traspaso a algunos de los clubes más importantes del mundo, como el Arsenal, el Manchester United F. C., el Tottenham Hotspur F. C. y el Bayern de Múnich. Fue galardonado con el premio al Jugador del mes de la EFL Championship de marzo de 2022 además de ser nominado para el premio al Gol del Mes tras su gol de larga distancia contra el Queens Park Rangers F. C. que finalmente se le concedió. Tras haber sido nominado también al premio al mejor jugador joven de la temporada en la Championship, consiguió un triplete de premios en marzo de 2022 al ganar el premio al mejor jugador joven del mes en la EFL por segunda vez en su carrera. A final de temporada lograron el ascenso a la Premier League.

El 19 de julio de 2022 se anunció su fichaje por el Tottenham Hotspur F. C. hasta 2027. En sus primeros meses en el equipo disputó seis partidos y terminó la temporada cedido en el Stade Rennais F. C.

Selección nacional
En marzo de 2022 obtuvo una primera convocatoria internacional con la selección de Inglaterra sub-21 para los próximos partidos de clasificación para la Eurocopa Sub-21 de 2023 contra Andorra y Albania. Debutó como suplente durante la victoria por 3-0 en el campo de este último el día 29.

Estadísticas

Clubes
 Actualizado al último partido disputado el .

Referencias

Enlaces externos

Nacidos en Londres
Defensas laterales derechos de fútbol
Futbolistas de Londres
Futbolistas del Middlesbrough Football Club
Futbolistas del Nottingham Forest Football Club
Futbolistas del Tottenham Hotspur Football Club
Futbolistas del Stade Rennais Football Club
Futbolistas de la selección de fútbol sub-21 de Inglaterra


CRIMINAL TRESPASSING II : Blaine Allen Stritmater, 27, Baker City transient, 7:01 a.m. Wednesday, at St. Alphonsus Medical Center, 3325 Pocahontas Road; jailed and later released. Police said Stritmater was arrested after he refused to leave the hospital after being told repeatedly not to return except in an emergency.
CRIMINAL TRESPASSING II: Linda Diane Peterson, 51, of 2450 Broadway St., 2:512 p.m. Wednesday, at New Directions Northwest Behavioral Health and Wellness, 2200 Fourth St.; jailed. Police said Peterson was arrested after she returned to the office building after being told by staff not to return for services again until Thursday.
POST-PRISON SUPERVISION VIOLATION (Baker County Parole and Probation detainer) and PAROLE BOARD VIOLATION (Oregon Parole Board warrant): Derrick Lamont Dodge, 27, of Nampa, Idaho, 11 p.m. Wednesday, in the 2300 block of Broadway Street; jailed. Two officers each from the city, county and state police agencies responded to the initial call of a disturbance in the 2400 block of Broadway Street, the press log stated.


This page takes you through the Stranger Mission or Sidequest Duchesses and Other Animals in Red Dead Redemption 2.
After being saved from choking on a nut during The Gilded Cage mission, stop by the greenery north of the middle of Saint Denis to meet a rather flamboyant gentleman in his shop of interesting and fancy items.
His name is Algernon Wasp and he wants you to collect items so he can make more of his items of fashion.
Egrets can be found in Bayou Nwa, north of Saint Denis.
Lady of Night Orchids can be found on the southern shore of Bayou NWA, north of the Kamassa River and Caliga Hall.
Herons can be found in Bayou Nwa, north of Saint Denis.
7 Lady Slipper Orchid can be found in Big Valley.
Moccasin Orchid can be found in Roanoke Ridge.
All items can be found in and around Bayou Nwa.
Spoonbills, Rat Tail Orchids, and Spider Orchids can be found in Bayou Nwa.
Night Scented Orchids can be found south of Braithwaite Manor.
Clam Shell Orchids can be found east of Caliga Hall.
Queen's Orchids can be found in Bayou Nwa.
Sparrow Egg Orchids can be found north of Roanoke Ridge.
Dragon's Mouth Orchids can be found in Grizzlies East.
Once you have returned to Algernon for the final time, you will receive an exotic hat and the exotic Algernon's Revolver.


Ho lavorato alla ferrovia, ragazzi, con il fango alle ginocchia.
con un po' di denaro per tirare qualche colpo di dadi.
Mi han detto: "Amico, ora sai che non ti sarà permesso uscire su cauzione"
Dio lo sa, son stato dappertutto in questo mondo.
Lord, I've been all around this world.
I went to work on the railroad, boys, the mud up to my knees.
God knows, I been all round this world.
I went up to the Midway Inn with money to shoot some dice.
God knows, I've been all around this world.
The new railroad is finished, boys, the cars are on the track.
The officers came and arrested me and they take me down to jail.
They said to me, "Old fellow, now you know you're allowed no bail."
They take me to the court house, boys, and there I had a crowd.
The sentence was to hang me, well I don't care if you do.
You all can sing this song, boys, when I am dead and gone.
God knows, but he went all around this world.