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Review: Crackdown 2
Shooting has actually gotten worse, with an auto-aim preternaturally consistent about never, ever targeting the thing you're looking at and no way to snap between targets.
Daniel McKleinfeld
Just about every gamer has suffered the perverse and humiliating delight of a bad game that you can't stop playing. You know that your time, your life, your precious youth is being callously wasted, but some terrible Pavlovian urge keeps the controller in your hands, even as you ignore spouse, friends, and much better games for the sake of pursuing something you don't even want. With lazy gameplay and unimaginative design, Crackdown 2 squanders the good will its unpolished but enjoyable predecessor earned, but it does offer some shameful, atavistic pleasure.
One good gameplay mechanic can make a weak title enjoyable, and in Crackdown, it's the jumping that renders the whole experience almost worth it. There's so much delight in the game's amiable physics that you're constantly tempted to ignore all the shooty-shooty and just enjoy playing the most cheerfully undemanding 3D platformer ever. Pacific City is once again full of buildings (mostly the same buildings, I'm afraid), all of them practically begging you to find a path to the top. Once you're on top of a three-hundred-story skyscraper, the obvious next step is to jump off it, at which point the nicely implemented wind and motion blur effects kick in to make falling an incredibly visceral thrill. It never stopped being a delightful surprise to survive a several-mile drop, with only a dent in the concrete to show for my epic plummet.
But when you come back to earth, you have to deal with the other legs of the Crackdown stool: shooting and driving. And they are some wobbly-ass legs. The driving is just what it was in Crackdown: like pushing a brick through glue. There are more cars to choose from, but it's a long way from the racing-game fundamentals that the Grand Theft Auto series always nails. And shooting has actually gotten worse, with an auto-aim preternaturally consistent about never, ever targeting the thing you're looking at and no way to snap between targets.
In any sandbox game, the quality of the sandbox matters a lot, but Crackdown's city is still utterly without personality. The audio logs (sigh, yes) lay out a reasonably interesting story of citizens vs. criminals vs. Agency vs. monsters, but none of that makes its way into the world, which is stocked with boring ads, citizens with nothing interesting to say, and buildings you can't enter. This is a prime example of one of game development's worst tendencies: The writers were stuck in a dialogue-writing box and no narrative was allowed to escape into the wild.
Plenty of other little problems from the first game remain unsolved. The narrator retains his Tourette's-like habit of butting in with suggestions totally unrelated to what you're doing. The music is still generic and badly cued. And while it was just barely acceptable to release an open-world game without waypointing when the first Crackdown came out, it's not okay anymore, and it's even worse when the minimap is so freaking broken (how in God's name do you screw up a minimap?!) that it almost never accurately shows you where the closest objective is.
Usually, game sequels try to expand the story, the characters, and the enemy types. Maybe the most original (not good, but original) aspect of Crackdown 2 is that it does just the opposite. The motely gangs of the first game are gone, replaced by exactly two types of enemies: criminals from the Cell gang and underground mutant Freaks (and if you think the latter is going to result in the constant in-game use of a certain '70s disco tune, you are already as witty as the game's designers). Once you've played through the first hour, you've seen just about every enemy the game has to offer. It's fun to drive your car through a crowd of splattering baddies, and kudos to the programmers who made it possible for so many of them to be on screen at once, but there's just not enough variation to keep it interesting.
Worse yet, they've totally lost the clever nonlinear structure of the first game, where you could take missions in any order and have each one affect subsequent missions. Instead, there's exactly five kinds of missions, you'll do them over and over, and there's nothing to keep you going but an urge for attrition. In the worst insult to the first Crackdown, none of the missions change the world in the least. You'd think that completing the Agency's citywide anti-Freak final solution, complete with dramatic cutscenes, would have some effect on the rest of the game, but instead, the instant the Death-of-the-Freaks cutscene finishes, the Freaks are right back where they were, cheerfully munching on civilians as though no one just wiped them from the face of the Earth.
The final addition made for the sequel is online multiplayer. And it's lame. You can play four-person co-op, which in theory should be a lot of fun, but trying it, I was quickly reminded that what makes Crackdown fun is the ease with which you can get distracted: I'm on my way to a mission, but decide to stop and investigate a far-off orb, or get involved in a shootout, or just grab a cool car. The difficulty of coordinating four people over an Xbox Live headset means these kinds of distractions are fatal to unit cohesion, so you're discouraged from playing the game as it's most fun to play.
Most obnoxiously, the single-player game is scattered with "Live Orbs," that the can only be collected in multiplaye. You might think that orbs that only affect multiplayer could simply be turned off when in single-player, but that would deprive the game's narrator of the chance to smugly scold you for playing alone every goddamn time you get anywhere near the goddamn Live Orbs. Look, Ruffian, I know you want to show off your networking code, but yelling "YER DOIN' IT WRONG!" when I'm trying to play the game you shipped is what swingers would call "a major turn-off."
Crackdown 2 didn't fix any of the problems of its predecessor, and it adds quite a few for good measure. It's boring, repetitive, and incredibly lazy. There's almost nothing to recommend it.
But it's actually kinda fun. I hate to say it, but it is. The first few hours are a slog, but once you've leveled up a bit, the basic running-shooting-jumping power-fantasy-fulfillment is entertaining, and the flashy orbs flying at you every time you so much as parallel park are a potent Skinner-box reward. Even as I was telling myself how inadequate the game was, I was still hooked on a "just one more mission" cycle.
If you're looking for a summer time-killer, you could do worse. But if you haven't played the first Crackdown, buy that one instead; it's a lot cheaper and a whole lot better, and I hate the thought that Ruffian Studios, a relatively new company with some real potential, is going to be rewarded for churning out this uninspired filler.
Developer: Ruffian Games Publisher: Microsoft Game Studios Platform: Xbox 360 Release Date: July 6, 2010 ESRB: M ESRB Descriptions: Blood and Gore, Strong Language, Violence Buy: Game
Review: Lego Harry Potter: Years 1 – 4
Review: Super Mario Galaxy 2


A very difficult decision had to be made tonight as Captain Beefheart's Magic Band were also in town. But a quick listen to Down Hearted Blues, a collection of reworked classics by Eilen Jewell, and that Sunday night gig quandary became a formality.
Originally from Boise, Idaho, Eilen Jewell is a waif like presence that belies a sensuous, confident and sensational performer. A fantastic, authentic interpreter of the blues and countrified Americana, with such a special voice that is equally at home in both camps.
She and her band effortlessly invoke the spirits of Howlin Wolf, Willie Dixon, Memphis Minnie and Betty James. The band tonight are tremendous, on huge double bass is Shawn Supra, the suave Mr Jason Beek is on drums, brushes and washboard..oh yes, we have a washboard scenerio!
And on the sweetest guitar you'll ever hear is the legendary guitarist Jerry Miller who has an illustrious career playing with the likes of Johnny Cash and was part of the nascent hippy movement as prime mover in the band Moby Grape with Skip Spence. He also knew Jimi Hendrix and is one of the greatest exponents of the guitar this side of Atlantis.
This was a mammoth set, two hours by my reckoning and covering all bases, including Shelf Blues, Rio Grande, Needle and Thread, Rich Man's World from her vibrant back catalogue.
Eilen Jewell's new recordings were superlative too. Another Night to Cry, Don't Leave Poor Me and especially Walking with Frankie really cooked up a storm. In virtually all the songs Miller played some incredible guitar licks. Restrained and concise, the epitome of a truly gifted musician and a privilege and pleasure to experience.
Between these beautiful tunes Eilen Jewell talks about her love for the blues, busking, falling in and out of love and how music got her through the hard times.
She tells of discovering her father's record collection and her early years in Boise, where she longed to break out and connect with something bigger. This desire to break free of your roots appears to be a common thread to many musicians.
She seemed genuinely grateful to receive vociferous calls for an encore and finished with a glorious version of Bang Bang Bang and a solo stab at Bob Dylan's Walking Down the Line which was mesmeric.
Support was from Sophia Marshall, a name you should remember for future reference, hailing from Leicestershire this singer songwriter has an easy relaxed style with a nice set of self penned tunes. Flanked by Andy Jenkinson and Sarah Marshall who contribute backing vocals and bass, the resulting melange of acoustica is a sweet thing, gentle, harmonious and blessed with some nice tunes.
Her latest album is called Bye Bye, from which most of tonight's short set came from and heartily recommended it is too.
Big eyed beans from Venus nil…….Eilen and Sophia, three.
Would have loved to have seen this.


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Q: Is the image of discrete set under an open map discrete? Let $G$ and $H$ be locally compact totally disconnected abelian groups, and $f:G\rightarrow H$ a surjective open map. Let $Y\subseteq G$ be a discrete subgroup in the subspace topology. Is it true that the image $f(Y)$ is also discrete in the subspace topology? If so, how can one prove it?

A: No, that's false. You didn't say that $f$ is a homomorphism, but the answer is still no if we require this.
Let $G = {\bf Z} \times C_2 \times C_3 \times C_5 \times \cdots$ be the product of the infinite cyclic group and the cyclic groups of all prime orders. Let $H = C_2 \times C_3 \times C_5 \times \cdots$ and let $f: G \to H$ be the obvious homomorphism with kernel ${\bf Z}$. Let $Y$ be the subgroup of $G$ generated by the element $(1, 1, 1, \ldots)$. It is a discrete infinite cyclic subgroup, but its image in $H$ is not discrete (in fact, it is dense in $H$).

redpajama_set_name: RedPajamaStackExchange


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Phoenix New Times Runs Three-Part Series on Whistleblower Police Officers
Bernabei & Kabat represents two Arizona police officers who were improperly disciplined after they raised concerns about how others were failing to do proper investigations of crimes. The Phoenix New Times published the first of a three-part series on these investigations and how the town mishandled the investigations and retaliated against the officers for their conduct in reporting these problems. The Phoenix New Times has continued its investigation of serious problems with the police department in Florence, Arizona, including problems identified by two of our firm's clients. The paper has also reported on the retaliation that our clients endured as a result of their reporting problems. This series has appeared in three parts ( Part 1; Part 2; Part 3), with a follow-up article appearing this week.

redpajama_set_name: RedPajamaCommonCrawl


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Child Trends / Project Case Studies / Dissemination of Child Trends report: "Home Front Alert: The Risks Facing Young Children in Military Families"
Project Case Study
Dissemination of Child Trends report: "Home Front Alert: The Risks Facing Young Children in Military Families"
This report found that children ages birth to six are especially vulnerable when one or both parents are deployed in a war zone, and from the effects of those deployments on the physical and mental health of the service members themselves. Young children are at higher risk of harm because of their emotional dependence on adults and their developing brains' susceptibility to high levels of stress. The negative impacts of high stress can impact young children long-term. Child Trends' communications effort drew attention to the risks to the 500,000 young children in military families, and also to the resources available to these families and the organizations that work with them.
Communications Strategies and Tactics
Child Trends developed an integrated mix of communication strategies and tactics to reach key audiences such as military family organizations, early childhood professionals, policymakers, media, and the military community. Child Trends wrote and distributed a news release on the report, and produced a 3-minute video, a Child Trends 5 (targeted newsletter) on the five risks facing young children in military families, and a social media toolkit for partner organizations. A number of key organizations and government offices were provided with a copy of the report prior to its launch and were invited to promote the findings. Child Trends also pre-briefed key print and broadcast reporters and orchestrated a proactive social media push on launch day. Three weeks after the launch, Child Trends co-hosted a Twitter chat for military families and organizations that serve them. Co-hosts included the U.S. Department of Defense, Military Families Learning Network, National Military Families Association, ZERO TO THREE, and Blue Star Families.
Media Coverage – Media coverage has totaled over 84 million media impressions. Key placements include: NPR, the Washington Post, TIME, UPI, Huffington Post, ABC Radio, CBS Radio, the Sacramento Bee, KIRO Radio, the Denver Post, the Buffalo News, the Virginian-Pilot, the Salt Lake City Deseret News, WTTG-Fox5, WJLA-ABC7, WTOP Radio (in Washington, D.C.), Stars and Stripes, and Bloomberg Businessweek.
Social Media – In addition to traditional media coverage, Child Trends engaged the public through strategic posts on Twitter and Facebook – which included promoting and linking to the report and accompanying video. The report has generated nearly 6 million Twitter impressions and 563 views on YouTube – a 68% increase over other recent top-viewed videos.
Policymaker Attention –The report attracted attention on Capitol Hill: a Dear Colleague letter was initiated on the topic, by the Chair of the Senate Budget Committee. Child Trends was also asked to discuss the report with the U.S. Department of Defense's Military Community and Family Policy office.
Topics: Early Childhood, Families and Parenting, Social and Emotional Development
Response to HHS Proposed Rule Allowing Discrimination Against LGBTQ Foster and Adoptive Parents


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Crossword Explorer Hong Kong - Level 205
Thank for choosing our site for all the Crossword Explorer Hong Kong - Level 205 Answers, Cheats and Solutions. This is the latest world in the last update by PlaySimple Games. On this update you will find unique crossword clues for you to solve. Chances are that some of the crossword clues will definitely be difficult for you to solve and you will need our help. This is the reason we have decided to share with you below all the Crossword Explorer Hong Kong - Level 205 Answers. You will be redirected to the appropriate game level after you click any of the crossword clues that we have shared with you.
Hong Kong - Level 205
1d. Actor Gibson from "Braveheart":
1a. Supervillain ___ Jojo from "The Powerpuff Girls":
2d. "___ or Another" song by Blondie: 2 wds.:
3d. Former Disney actors Joe, Kevin, and Nick who shot to fame with their titular TV series:
4d. Dental hygiene, say:
5d. Addled due to aging (Anagram of "enisle"):
SENILE
5a. "Sir" in Spanish:
SENOR
6d. Indian garments that are draped:
6a. Former Disney child actress, ___ Gomez who shot to fame with her TV series "Wizards of Waverly Place":
7d. Former Disney child actress, ___ Lovato who shot to fame with her TV series "Sonny with a Chance":
7a. "Angels & Demons" novelist Brown:
8a. ___-mart (former name of a popular retail chain):
9a. Actress Durance and author Jong:
ERICAS
10d. ___ Lo Green, former coach on "The Voice":
11a. Former Disney child actress, ___ Cyrus who shot to fame with her TV series "Hannah Montana":
12a. "Oh, that's what you mean!": 2 wds.:


Make sure every beverage you serve is branded with your name and logo. Our 10oz White Disposable Coffee Cups are perfect circulating your name and product in an economical and creative way. The one color option allows you to save space and cash by ordering as little as one case of custom printed paper cups.
Our 10 oz coffee cups feature a tightly rolled rim and a poly-lined interior to prevent leaking and keep your customers clean and safe. Due to its strength and durability, this cup is sure to be a must-have for any restaurant, coffee shop, or special event. White disposable coffee cups are available in sizes 4oz to 24oz.


Asha Negi Height, Weight, Age, Wiki, Biography, Boyfriend, Family & more. Asha Negi is an Indian Actress, who featuring in Hindi Television Serials. She was born on August 23, 1989 in Dehradun, Uttarakhand, India. Asha Negi Age 28 Years Old. She was made her debut in Star Plus Serial 'Sapnon Se Bhare Naina' which released in 2010.
Asha Negi performs in several popular TV Series like, Pavitra Rishta, Punar Vivah, Bigg Boss 6, Jamai Raja, Kumkum Bhagya, Yeh Hai Aashiqui, Code Rose, Aaj Ki Raat Hai Zindagi, Kalieren etc.
Asha Negi is the daughter of Beena Negi and father name unknown. She attended St. Mary's Higher Secondary School, Dehradun and then admitted to D.A.V. College, Dehradun, from where she finished Bachelor of Commerce. She is Unmarried and dating with Rithvid Dhanjani.
In her physical stats, Asha Negi Height 5 ft 5 in or 165 cm and Weight 55 Kg or 121 Pounds. She build with hourglass body measurements are 34-25-35 inches. Her hair is black and eye is brown colored.
An another article we shared details body measurements of Actress Archana Puran Singh, Archana Kavi, Archana Gupta, Aparna Balamurali, Nandana Sen.
We Shared a completed details about Asha Negi Height, Weight, Age, Wiki, Biography, Boyfriend, Family. Do you have something about this article? let us know in comment. You can follow this celebrity on Instagram, Twitter, Facebook, YouTube, Google+ & More.


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Q: Error converting HTML/CSS to PDF using PHP I build bar codes using jquery in a div in my web app.
The black bars are contructed as a set of div tags with their background as black or white as follows,

I have tried multiple PHP packages (htmp2pdf, dompdf, tcpdf) to convert this to PDF but come up with either a blank PDF or an error as it sees nested div in the content.
Can anyone tell me how can I convert these generated barcodes to PDF suing PHP?

A: Try wkhtmltopdf which is a simple shell utility to convert html to pdf using the webkit rendering engine.
To use it, unpack it and run it like this:

> wkhtmltopdf www.mydomain.com/barcode3 barcode3.pdf

Basically, it will run over n HTML pages and generate PDF's without the overhead of purely dynamic PDF generation!
This might offer you a solution, but you'll need to check the requirements and see if it fits with your server constraints. It worked really well when we used it for producing accurate reports directly from HTML.
EDIT: EG, running it as a potential user function from within PHP:
For Linux:
exec("wkhtmltopdf http://mydomain.com /home/user/$user.barcode3.pdf 2>&1");

For Windows:
<?php
exec('C://path/to/package//wkhtmltopdf http://mydomain.html barcode3.pdf');

echo "PDF Created Successfully";
?>

A: Would it help if you used  data instead of drawing the bars with
 rectangles? Not sure if you need Code 128 or another symbology, but there is a complete set of inline (base64) Code 128 images at http://notionovus.com/blog/code-128-barcode/.
I initially tried to generate barcodes by drawing rectangles, but found that letting the browser do the scaling saved me a lot of work. Sounds like the
 tags have their down side as well.


Need that extra reinforcement in your countertop?
Rodding is the best way to reinforce the sink cutout in your countertop. Rodding adds strength to the weaken are and allows the top to transported without risk of breaking. These blades will attach to a stone cutting saw such as the Alpha AWS-125 Wet Stone Cutter, or can be attached to a grinder like the Makita 9565CV 5" Angle Grinder.
With several choices of rodding blades, we also have a variety of rodding!


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Maritime Navigation
Maritime liability and insurance regimes
Claims for damage caused by fuel oil
Claims for passenger injury and damage to luggage
Claims for pollution damage caused by oil from oil tankers
General maritime claims
Principles of liability limitation
Coastal trading
Australian International Shipping Register
Coastal trading licensing and publications
Contact the Shipping Business Unit
Tax incentives—Australian shipping
Applying for tax incentives
Additional requirements for ITE
Consolidated information on certificates and notices
Shipping exempt income tax incentive
Accelerated depreciation and roll-over relief
Seafarer tax offset
Royalty withholding tax exemption
International liner shipping
Part X of the Competition and Consumer ACT 2010
Designated shipper bodies
Registration process for conference agreements
Maritime workforce
Maritime labour convention
IMO/ILO guidelines on seafarers welfare
Marine environment protection
The National Plan for Maritime Environmental Emergencies
Protection of the sea legislation
Control of harmful anti-fouling systems on ships
Navigation Act 2012
National Maritime Safety Regulator
Guidelines for commercial shipping rescuing persons at sea
Australian Maritime Safety Authority
Maritime consultation
Maritime publications
Tasmanian transport schemes
Tasmanian Freight Equalisation Scheme (TFES)
Bass Strait Passenger Vehicle Equalisation Scheme (BSPVES)
Home > Maritime > Maritime Publications > Factsheet: Coastal Shipping Reform
Factsheet: Coastal Shipping Reform
Australia's shipping task and industry
Only 17% of Australia's domestic freight task is performed by coastal shipping. Despite a dramatic 57% growth in total Australian freight over a decade, the share carried by coastal shipping has plummeted. W ithout action, coastal shipping will continue to lose market share to road and rail, adding to congestion in our cities, higher transport costs and extra wear and tear on infrastructure.
The number of major Australian registered ships with licences to move coastal freight fell from 30 in 2006–07 to just 13 by 2012–13. W hile the number of vessels has marginally risen since the period of the Australian Sea Freight 2012–13 Report, deadweight tonnage has plummeted by 64% over the last two years.
The importance of coastal shipping
Coastal shipping moves vital cargoes around Australia including coal, fertiliser, petroleum products, liquid petroleum gas (LPG), metallic ores and mineral sands, cement and steel. Coastal shipping also covers the movement of passengers on domestic cruises and ferry services.
In the 2013–14 financial year, almost one million metric tonnes of fertiliser was moved on ships between Australian ports. Fertiliser supplies from Queensland were transported to many ports including Newcastle, Geelong and Adelaide to support Australian farmers.
Similarly, in the same period a total of just over 278,000 metric tonnes of LPG products and just over 6.4 million metric tonnes of petroleum products were moved via coastal shipping. These movements highlight the importance of coastal shipping in meeting Australia's energy and fuel needs.
The Business Council of Australia stated around 90,000 Australians are employed in manufacturing sectors using coastal shipping, including oil refining, cement, steel and aluminium production.
Coastal shipping is also particularly important to the Tasmanian econom y, providing the only viable bulk transport link to the mainland with Bass Strait a fundamental part of the supply chain. This means the cost of transport across this tract of water must be competitive.
Between 2000 and 2012, shipping's share of Australia's freight task fell from around 27% to just under 17%, while the volume of Australian freight actually grew by 57%.
Australian shipping is uncompetitive. An Australian ship can cost around $5 million a year more than a comparable foreign ship on comparable routes.
Australia's major coastal fleet fell from 30 in 2006–07 to just 13 by 2012–13. Today it is 18, however, deadweight tonnage has plummeted by 64% in the last two years.
Just 49 million tonnes of coastal freight was loaded in 2012–13. Five years earlier (2007–08) it was over 59 million tonnes—that's a 2.4% decline each year in the total weight of coastal freight.
Over 2010–30 Australia's freight task is expected to grow by 80%. W hile national road and rail freight is projected to double, coastal shipping will grow a mere 15%.
Reform of coastal shipping
On 8 April 2014 the Australian Government released an Options Paper on approaches to regulating coastal shipping in Australia. The Paper was well received by industry. The Department of Infrastructure and Regional Development received a total of 85 submissions and is continuing to receive supplementary submissions and additional information.
The submissions highlight the problems experienced by producers, manufacturers and other users of coastal shipping with the current system.
The five voyage minimum requirement before a temporary licence can be granted hinders the ability to move one-off cargoes by coastal shipping. For example, a piece of heavy machinery was unable to be shipped as a single voyage and, therefore, a Temporary Licence could not be granted. The machinery was moved by road, which required a police escort due to the over-size load and removal of overhead power lines. This was more complicated and costly than a voyage by ship.
Certain products, like LPG, are moved exclusively by foreign ships operating under temporary licences. Even though there are no Australian ships capable of carrying the products, the shippers must still obtain licences for the movement of the goods. This is a costly and time consuming process that delivers no value to the Australian economy.
Tolerance limits make the current system inflexible for coastal shipping users. The tolerance limit for the amount of cargo carried means last minute changes to cargo cannot be made, or if a change has to be made, the ship is delayed while waiting for the change to be approved.
Ships carrying petroleum products from offshore petroleum production facilities are not able to apply for a temporary licence, making it difficult to bring those petroleum products directly to mainland Australia.
Submissions on the Options Paper have highlighted cost pressures faced by coastal shipping users.
Bell Bay Aluminium has indicated an increase in costs from $18.20 a tonne in 2011 to $29.70 a tonne in 2012—an increase of 63% following the introduction of the existing regulations.
Others, including Bell Bay Aluminium, cite delays costing foreign vessels around $10,000 a day and more than $20,000 a day for Australian ships. Stakeholders have indicated it is cheaper to import products from Asia than using coastal shipping to move those same products around Australia.
Overall, submissions share a common goal to reform the current regulations to increase flexibility and affordability for users of coastal shipping.
The Australian Government is carefully considering these issues and is committed to developing an internationally competitive coastal shipping framework that enables the industry to operate effectively, efficiently and in the national interest.
Last Updated: 7 January, 2015


Have you got bad posture?
What is gait analysis and what can it do for me?
Bedford triathlete, Gill Fullen, coaches duckling "Fullen" – Swim, Run covered – bike coach TBC! The importance of rest and regular preening also noted. Clever duck.


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White Disappoints Fans: 'Fight between Adesanya and Costa not agreed'
Dana White denied information about arranging a fight between Israel Adesanya and Paul Costa.
Nearly all martial arts media, including us, reported this morning that the fight for the UFC middleweight title, between Israel Adesanya and Paul Costa, arranged for the UFC 253 event to be held on September 19, is likely to be on Fight Island again.
But it seems we have rushed a bit on this information, as Dana White was not ready to confirm that fight. In fact, the UFC president has revealed how things stand at the moment.
"That's not true, they both haven't signed a contract yet. They were told no to say anything, but Combate immediately announced it as soon as it got the information. That fight hasn't been agreed yet," White told a news conference after the latest Fight Island show.
Since Costa announced that the fight has been arranged, it is assumed that Adesanya is the one who has not yet signed the contract, that is, with whom the UFC has still not been able to agree. Whatever the problems, we can only hope that they will be solved soon.


Please praise God for His favor on the Children & Youth Ministry and pray for the Children & Youth Ministry's continued impact on all those coming to CBS.
Please pray for God's provision for the leaders in the Rochester East, New York, day class to help them finish the year well, for God to raise up the leaders needed for next year and for the class participants to be bold in inviting others in their community to the upcoming visitors days.
Please praise God for the unity and fellowship He has built among Area Directors in the Atlanta Zone during the pilot. Pray that He will continue to fill them with His vision for reaching all in their communities as they seek the Lord for ways to serve together.
Please pray for the students and leaders of The Dalles, Oregon eTeen class to finish the year strong while focused on God's word and applying what they have learned in their lives.
Please pray for safe travel and uplifted spirits for the trainees coming from across the county and around the world to Colorado Springs for the Spring Leadership Training. May this be a time of spiritual growth, renewed energy and enthusiasm for seeing lives transformed through the Word of God.
Please pray for faithfulness and encouragement in all the classes in Italy.
Please pray for God's wisdom and guidance as CBSI leadership changes take place in Togo.


New York: It's better to ignore simple ovarian cysts as researchers have found that such cysts are extremely common in women and do not require additional ultrasound surveillance or surgical removal.
"Our study found that asymptomatic simple cysts of any size should be considered normal findings in women of any age and ignored," said corresponding author Rebecca Smith-Bindman, Professor University of California, San Francisco (UCSF) in the US. "There's a great deal of unnecessary medical surveillance that goes on for simple cysts," she said.


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Wearables Reviews
By Pranay Parab | Updated: 16 November 2018 18:38 IST
Apple Watch Series 4 has a fantastic display
It supports ECG, but that feature isn't available in India yet
The 40mm Series 4 GPS starts at Rs. 40,900; LTE at Rs. 49,900
The Apple Watch is not just a niche smartwatch anymore. In fact, Apple claims it's the most popular watch — smart or otherwise — in the world. The Series 4 is the latest generation of this product line, and it adds several features that sound great on paper. This includes the ability to take ECG readings, fall detection, larger and better displays that go all the way to the edge, and an improved heart rate sensor.
The Apple Watch also has GPS to track your runs accurately, and can be worn while swimming to track your swims as well. Unfortunately, the ECG feature doesn't yet work in India for want of the necessary regulatory approvals, though that might change in the future. But how does the rest of the package hold up? Read on to find out.
Apple Watch Series 4 design, display, and setup process
If you already have an older Apple Watch, you'll immediately notice two things about the new Apple Watch Series 4 — the display, and the new heart rate sensor. The Apple Watch Series 4 has a display that extends nearly to the edge of the screen. The Series 4 sizes are now 40mm and 44mm rather than 38mm and 42mm. The interesting thing is that all existing Apple Watch bands still work with the Series 4, but remember that 38mm watch bands are compatible with the 40mm Series 4, and the 42mm bands with the 44mm Series 4. This is a nice move on Apple's part and it rewards those who've already bought a bunch of bands.
The optical heart rate sensor has just one LED instead of the four that previous models had. A more subtle change is that the digital crown now doubles as an electrical sensor too. These two can be used in conjunction to collect better heart rate data, which we'll talk about in depth later.
The Series 4 models, just like with the Series 3, have LTE variants to allow you to make phone calls and receive messages even when your phone is switched off. Luckily, the gaudy red circle on the LTE version's digital crown has been replaced with a much subtler red ring. It's nice to look at, but we think it's unnecessary to differentiate the two models visually. The speaker occupies more space on one side, and the microphone has been moved to the other side, between the digital crown and the side button.
The display is one of the standout features of the Apple Watch Series 4. Having a little bit of extra screen space has allowed Apple to introduce some new watch faces and tweak its existing ones, as well as displaying more Complications (Apple's term for widgets). Our favourite watch face, Activity, now shows the time in seconds as well — it's still just hours and minutes on older Apple Watch models.
We had no issues with legibility on the display, and the Series 4's 44mm screen almost felt a bit too large when compared with the 42mm Apple Watch Series 2. We think the 40mm variant might be big enough for many people, even those who used the 42mm Apple Watch models. The Sport band is extremely comfortable and we never felt like taking the Apple Watch Series 4 off our wrist, except of course to charge it.
The Series 4 has a larger display, one that extends almost to the edge of the screen
The Apple Watch Series 4 uses the same magnetic charging cradle as its predecessors, which is a big plus in an industry where companies such as Fitbit seem hell-bent on designing different chargers for each new product. Apple has changed the box for the Series 4, making its shape longer and thinner. We received the 44mm stainless steel LTE variant with the Sport band for review, which is priced at Rs. 71,900 in India.
The setup process is simple enough. You just have to open the Watch app on your iPhone 5s or newer iPhone (Series 4 ships with watchOS 5, which isn't compatible with older models) and follow the simple on-screen instructions. For the LTE variant, you'll see a page called Mobile Data Setup, and if you choose to set up LTE at the outset, you will be redirected to your telecom carrier's website to log in and set up the Apple Watch's eSIM.
You'll be using the same phone number as the SIM in your paired iPhone, so it is worth noting that at the moment only Airtel and Reliance Jio support Apple Watch Series 4 LTE in India. The setup process was pretty smooth, and we managed to get LTE working instantly. However, after having un-paired and re-paired the Apple Watch a few days later, we had issues re-activating LTE on Airtel.
Apple Watch Series 4 watch faces
There's a new Series 4-exclusive Infograph watch face, which lets you have as many as eight complications apart from showing the time and a calendar entry. Each of the four corners of the display allows for one Complication, and there are four more within the dial. This allows people to customise the watch face to suit their needs and get all the information they need at a glance.
As nice as it is to have all these options on the Infograph watch face, we were left wondering why you can't instead show information from certain apps. Apple's own apps such as Messages and Phone can't be added as Complications on this watch face, which is baffling. We'd have expected that all of Apple's apps would be well-integrated with watch faces, but clearly that is not the case here. However, a new report suggests that this could be coming soon.
Third-party developers still can't create watch faces for people to download, but we can keep hoping that that's in the works for next year's release.
Infograph (left) is a new watch face, and Activity (right) shows the time in seconds as well on the Series 4.
We think watchOS still needs to evolve a little to better support the LTE variant of the Apple Watch Series 4. We don't like the fact that you have to swipe upwards from the bottom of the screen to see the strength of the LTE signal (unless you use the Explorer watch face, which isn't one of our favourites). If there is no signal, you see a red X icon at the top of the screen, which is good but not enough. This is exactly the kind of information that should be displayable as a Complication on any watch face, but as of now, it remains unsupported.
There should also be a way to quickly launch the Phone app to make calls. Right now, you still have to go to the app drawer, which feels laborious for what is one of the headlining feature of the world's most popular smartwatch.
Apple Watch Series 4 software, apps, and ecosystem
Apple has steadily been working on making the Apple Watch more than just an iPhone accessory. The LTE variant can work without your iPhone being within range all the time, but it isn't a standalone product and still needs to be paired with an iPhone during setup. Also, the Apple Watch's functionality is still somewhat limited when used untethered.
At the time of writing this review, only four of the top 50 free iPhone apps on the App Store in India — — Facebook Messenger, Jio Music, Ola Cabs, and Uber — were available for the Apple Watch. Sure, not all of them would be a good fit for the Apple Watch (camera apps, photo and video editing apps, video streaming apps, for example), but not having Google Maps or even WhatsApp does hurt the Series 4's utility as a standalone device.
When your iPhone is on and within range, you can quickly reply to WhatsApp texts. If your iPhone is switched off, you won't even get notifications from apps like WhatsApp because they don't have a corresponding Apple Watch app. However, if you leave your iPhone at home when it's connected to Wi-Fi or mobile data and head outside with your Apple Watch, you will receive notifications and be able to reply to them via the watch, as long as your Watch as Internet connectivity.
We made lots of phone calls through the Apple Watch Series 4 during our review period. The microphone worked well even when we were walking with our hands at our sides, but we still had to raise our hands to our faces like characters from a 70s spy movie to hear the other party clearly. You might have a different experience based on how noisy your surroundings are. Most people will either pair the watch with AirPods or other Bluetooth headphones while making calls, and that is a much better way to use the Series 4 LTE for phone calls.
The Explorer watch face shows LTE signal strength and a Complication to quickly open the phone app.
There are a few other neat features such as being able to open some websites on the watch itself (via the Messages app) and the ability to trigger Siri just by bringing the watch close to your mouth — there's no need to say "Hey Siri" anymore. Siri has improved a bit, and can now perform tasks such as setting alarms and playing music pretty well. However, in our experience, it didn't reliably open every time we spoke a command to the watch, which was frustrating. Once, we said, "Hey Siri" with the watch close to our lips and it got triggered on our iPhone but not the watch.
The Apple Watch remains the best smartwatch for the iPhone due to its tight integration with iOS. A tiny little new feature that makes a world of a difference is that, like iOS 12, watchOS now groups notifications by app. This allows you to quickly dismiss pesky alerts on the watch itself, without having to scroll through an endless list.
Apple Watch Series 4 fitness tracking
The one purpose that we would highly recommend the Apple Watch for is fitness. Ever since the Apple Watch Series 2 was launched, it's been pretty clear that exercise tracking is the best feature of the Apple Watch. The Series 4 doesn't have any exclusive new fitness-oriented features, and you can track all the same workouts on older Apple Watch models too. Still, we were quite excited to check out what improvements the new heart rate sensor brings, and whether that merits upgrading to the Series 4.
Automatic workout detection, introduced with watchOS 5, allows the Apple Watch to log workouts that you forget to trigger. It even shows a notification asking you to confirm that you've finished a workout. We found these alerts to be largely accurate, apart from one instance when the Apple Watch thought we had begun an elliptical workout when we were in fact sitting in an auto-rickshaw on Mumbai's potholed roads – and we don't blame the device for that at all. It was also pretty good at alerting us about ending our workouts — we always got these while stretching after a run or gym session.
The Series 4 (left) has a much improved heart rate sensor when compared with the Series 2 (right).
We like the new Activity Competitions feature that lets you challenge friends and motivate yourself to stay active. We kept checking our score every day and tried our best to win the competition, which is a nice way to avoid being lazy. It's actually quite easy to cheat here — you can simply set your daily move goal to 10 calories (Force Touch the activity rings in the Activity app) and quickly earn the maximum possible 600 points in a day. Even if you bring the calorie goal back up to your normal level, the earned points don't disappear. Perhaps we need a feature that doesn't allow for changing the move goal when a competition is on.
For runners, previous-generation Apple Watches have proven themselves to be pretty good. With watchOS 5, the Apple Watch can now track cadence data (the number of steps you take per minute), which is useful for runners. For those who don't follow the running circuit, cadence is one way to verify whether someone actually ran a particular distance or whether they simply enjoyed a car ride with GPS tracking enabled. The car ride would obviously show a much lower cadence than running. There was no easy way for us to verify the cadence data that the Series 4 recorded, but it seemed to be accurate enough based on our pace.
Activity competition is a fun new watchOS 5 feature that lets you challenge your friends to a fitness battle.
We ran the Apple Watch Series 4 through our standard tests as well. We manually counted 1,000 steps while walking and found the Apple Watch to be very accurate — it measured 1,002 steps. Then we performed our GPS test on a 1km stretch that we have measured using the odometer of a car. The route takes us under a flyover and through an extremely busy stretch of the road next to several skyscrapers. We switched off the paired iPhone during this test for the most representative result, because the Apple Watch can use a paired iPhone's GPS to get a quick lock on your location. At the end of the 1km walk, the Apple Watch reported the distance to be 1.03km. This is a pretty impressive result, and we also found that the deviation was non-existent in open spaces where GPS devices usually face no trouble in tracking your precise location.
You can set pace alerts while running, which means that if you want to run at 6 minutes per km, the watch will alert you if you deviate from this pace. There are two types of alerts — rolling and average. Rolling alerts check your pace in real time, while average alerts are triggered only when your average pace is falling short of the target. If you're training for a marathon, these will help you ensure that you aren't running too fast or too slow. These worked very well for us during our runs, and it's a good thing that this feature is now available on Series 2 and 3 as well.
Pace alerts allow runners to avoid running too fast or too slow during training.
We weren't able to test swim tracking with the Series 4 during our test period but this feature has worked well for us with the Series 2 and we expect it to be similar with the Series 4. We did go to the gym multiple times and tracked those workouts. Here's the best thing about the Series 4 — the improved heart rate sensor results in much more accurate workout data. We wore the Series 2 on one hand and the Series 4 on the other for multiple gym sessions and found that the Series 4 was much quicker to detect changes in heart rate.
With regular high intensity interval training, the built-in HIIT mode did a great job on both devices, but the heart rate sensor of the older model sometimes took a few extra seconds to detect a jump in heart rate. There were no such issues with the Series 4, which was on the ball all the time. We even compared it against a pulse oximeter, and the results were more or less an exact match.
If we have one complaint about the fitness-related features of the Apple Watch Series 4, it would be the lack of a proper strength training mode. If you want to log 50 pushups, 50 sit-ups, and 50 pull-ups at the gym, you'll have to rely on third-party apps. It's impossible for a wrist-worn device to know that you've done any number of squats or push-ups. The Apple Watch also still lacks built-in sleep tracking, but there are free apps such as Sleep++ to fill that gap.
We've felt for a while that Apple could do a lot more to help people train, beyond just helping people track their activity. This means that the Apple Watch, at some point, should have a training mode that features guided workout plans that you can follow directly from your watch. Those could be for achieving a goal such as training for a marathon, or a nice strength training routine. We wish the subtle taps on your wrist that alert you every time you've closed an activity ring could be used to prompt you to do another set of an exercise, followed by a rest time, and then the next set. It's not an easy problem to solve, but it definitely could increase the appeal of the Apple Watch for those who value strength training over everything else.
If you're among those who are just trying to get active or reduce stress, the Apple Watch is still a pretty good product for you. We think this group of people doesn't need the Series 4, because the Series 1/ Series 2/ Series 3 models will get the job done for a lot less money. The three activity rings — Move, Exercise, and Stand — are excellent motivators to get people moving. You just have to be active enough to hit your daily calorie target, exercise for 30 minutes a day, and stand up for a minute once every hour for 12 hours. These rings have been around since the first Apple Watch, and many people anecdotally report being or at least feeling fitter thanks to this feature. The Breathe app periodically reminds you to take a minute to breathe deeply to reduce stress. It works very well and you can do this without moving an inch.
The Infograph watch face is exclusive to Apple Watch Series 4.
We never actually fell during our review period, but we did drop the Apple Watch Series 4 once and it accurately detected it as a fall. This is the new fall detection feature that is unique to the Series 4, and it can alert emergency services if you don't move for 10 seconds after falling. This is a nice feature to have, even if it's one you hope you never have to use. This feature is enabled by default only if you list your age as over 65 during setup. Otherwise you have to enable fall detection manually via Settings in the Watch app.
Battery life without LTE was a solid two days, but with it enabled and our paired iPhone switched off, the Series 4 barely lasted us six to eight hours. Of course that's not how most people would use the Watch, so that number is a bit extreme. With LTE enabled and the iPhone switched on and near the Apple Watch most of the time, the battery went down from 100 percent at 6am to 14 percent at 10pm, so it should last you a full day.
A 30-minute run while streaming music via LTE to our AirPods brought the battery down by 13 percent. This is not bad, but long-distance runners who'd be running for over two hours while training will likely have to download music to the watch instead of streaming it.
All of this leads us to conclude that the Apple Watch Series 4 is an excellent upgrade over the Series 3, but we do have our share of quibbles. The ECG feature isn't available in India right now, the app ecosystem is quite weak, and the LTE variant of the Series 4 needs watchOS to evolve further.
We really love the fitness-related features of the Apple Watch Series 4, and its display is just stunning. We'd go so far as to say that it's the best screen we've seen on any watch so far. The Apple Watch Series 4 starts at Rs. 40,900 for the 40mm GPS version and Rs. 49,900 for the cellular variant. The starting prices for the 44mm equivalents are Rs. 43,900 and Rs. 52,900. This is a significant jump from the Rs. 32,000 starting price of the Series 3 at the time of its launch.
While there is a lot to love about the Apple Watch Series 4, it is hard to justify the price. The LTE variant is almost a luxury item at this point, and we don't think it's worth paying a huge premium for it, especially because the ecosystem isn't ready. Also, it will only work with Jio and Airtel right now.
The GPS variant would be our recommendation for those who want the best smartwatch for their iPhone. If you only care about fitness features and won't miss the bigger display or fall detection, the Apple Watch Series 3 is almost as capable and starts at Rs. 28,900 right now for the GPS variant and Rs. 37,900 if you need LTE. You still get an excellent watch for running, swimming, and general fitness, as well as watchOS 5's new features including grouped notifications and improved workout data. Battery life is also similar, making last year's version an excellent value pick.
Stunning display
Accurate fitness tracking and heart rate sensor
Good battery life (non-LTE)
Weak app ecosystem
Lacks built-in sleep tracking
Design and comfort: 4.5
Tracking accuracy: 4.5
Software and ecosystem: 3.5
Battery life (GPS): 4 (LTE): 3
product Apple Watch Series 4 has fall detection, a much larger display, and an improved heart rate sensor. Is it still the best watch for fitness enthusiasts? We review.
Further reading: Apple, Apple Watch Series 4, Apple Watch Series 4 price, Apple Watch Series 4 price in India
Pranay Parab Email Pranay Pranay is in charge of podcasts and videos at Gadgets 360. Over the years, he has helped build the tutorials section of this site from the ground up, got the Guide section off the ground, started two podcasts, written several in-depth features, reviewed fitness gadgets, handled social media and most recently, taken charge of videos as well. He loves travelling, particularly to places not frequented by tourists. He keeps running half-marathons across the country and hopes to complete a full ...More
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MESSAGE Pranay Parab


text:
using Balanced;
using System.Collections.Generic;

Balanced.Balanced.configure("{{ api_key }}");

List<Refund> refunds = Refund.Query().All();

redpajama_set_name: RedPajamaGithub


Hygiena's EnSURE monitoring system uses one instrument to collect, analyze, and report data from multiple quality indicators. Featuring new state-of-the-art technology and patented designs, the EnSURE is a simple-to-use, flexible, and accurate quality monitoring system.
Small, lightweight, handheld instrument (0.57 lbs., 7 x 18. x 3 cm), quick-test mode enables ad-hoc testing, large viewable screen with backlight and optional bold text, powered by 2 x AA batteries for several months of uninterrupted use, connects to SureTrend software via USB.


text:
IGDA Statement on King Trademark
As an advocacy organization for game developers, the IGDA diligently monitors issues that may restrict a developer's ability to create and distribute his or her work. After reviewing the Trademark filing and subsequent conduct by King Inc. in relation to its popular game, 'Candy Crush Saga,' we feel we should comment.
While we understand and respect the appropriate exercise of Trademark rights, King's overreaching filing in its application for the Trademark for its game "Candy Crush Saga," and its predatory efforts to apply that mark to each separate word contained in that name, are in opposition to the values of openness and cooperation we support industry wide, and directly contradict the statement King's CEO, Riccardo Zacconi, made on 27 January (http://about.king.com/about/our-approach-to-ip). Our Business and Legal Special Interest Group will be providing a more comprehensive analysis of this issue from its perspective soon.


BuzzOff insect repellent travel wear repels mosquitoes, ticks, fleas and other biting insects. The high performance fabrics offer 30+ SPF sun protection and are engineered for all-climate comfort. Pictured above is the Men's Buzz Off Check Shirt ($79).
Magellan's website also has helpful travel tips. If you'd like to order the catalog instead of shopping online, call 800-962-4943.


How to "Print" Excel Sheet on Custom Page Size like Din A1?
Printing Inkjet - ink and printers are cheaper to replace than toner and laserjets, and the edges hold up well after scoring/folding, but it doesn't print on all paper types, the resolution may be lower, and any moisture (e.g. sweat from hands) can ruin the colour.... 123D Make lets you slice up 3D models into different 2D pieces that you can then cut out and assemble, as shown in this tutorial. It is currently only available for the Mac. It is currently only available for the Mac.
In this tutorial, I will show you two methods for converting .STL files designed for 3D printing into vector files for vector laser cutting using either Rhino 3D or Autodesk 123D Make. NOTE: Please be warned, your laser cutter may operate differently from the Lab's Epilog Mini 24.... Start by designing the whole case first then cut the finalized model in two. Try fixing the top and bottom parts without using screws. 3D printing offers a lot of possibilities for designing a case with snap fits (e.g. clicking, using pins) .
Allow the finished print to dry completely before attempt to frame the PVC sheet. Hold the PVC sheet by the edges to avoid touching the printed surface. Place the printed PVC sheet in a safe place away from heat and moisture and allow it to dry completely. PVC prints will usually dry in about 15 minutes.


text:
<?php

/* Usage:
 *
 * class MyGroup extends ProcessGroup
 * {
 * 		public function setup()
 * 		{
 * 			$this	->incoming()
 * 					->pipe(new Process())
 * 					->pipe($this->outcoming());
 *
 * 		}
 *
 *
 * }
 */
namespace koolreport\core;

/**
 * Class for grouping processes into one.
 *
 * @category  Core
 * @package   KoolReport
 * @author    KoolPHP Inc <support@koolphp.net>
 * @copyright 2017-2028 KoolPHP Inc
 * @license   MIT License https://www.koolreport.com/license#mit-license
 * @link      https://www.koolphp.net
 */
class ProcessGroup extends Process
{
    /**
     * Settings of this Group Process
     *
     * @var array $params Settings of this Group Process
     */
    protected $params;

    /**
     * The starting process
     *
     * @var Process $startProcess The starting process
     */
    protected $startProcess;

    /**
     * The starting process
     *
     * @var Process $endProcess The starting process
     */
    protected $endProcess;

    /**
     * Constructor
     *
     * @param array $params The parameters for group process settings
     *
     * @return null
     */
    public function __construct($params=null)
    {
        parent::__construct($params);
        $this->startProcess = new Node();
        $this->endProcess = new ProcessGroupEnd($this);
        $this->setup();
    }

    /**
     * Setup the piping processes
     *
     * This method will be overwritten by descendent to provide the flow of processes
     *
     * @return null
     */
    public function setup()
    {
        //overwrite this function
    }

    /**
     * Get the starting process to start piping data
     *
     * @return Process Return the starting process
     */
    protected function incoming()
    {
        return $this->startProcess;
    }

    /**
     * Get the end process to pipe data to
     *
     * @return Process Return the end process
     */
    protected function outcoming()
    {
        return $this->endProcess;
    }

    /**
     * Receive the meta data from source
     *
     * @param array   $metaData Metadata sent from source nodes
     * @param Process $source   The source process
     *
     * @return null
     */
    public function receiveMeta($metaData,$source)
    {
        $this->streamingSource = $source;
        $this->metaData = $metaData;
        $this->startProcess->receiveMeta($metaData, $this);
    }

    /**
     * Event on input start
     *
     * When receive input start signal the group process will
     * forward to starting node
     *
     * @return null
     */
    protected function onInputStart()
    {
        $this->startProcess->startInput($this);
    }

    /**
     * Event on input end
     *
     * When input is ended, it forward to signal to starting process.
     *
     * @return null
     */
    protected function onInputEnd()
    {
        $this->startProcess->endInput($this);
    }

    /**
     * Send meta data to the next nodes
     *
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     *
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    public function metaFromEndProcess($metaData)
    {
        $this->sendMeta($metaData);
    }

    /**
     * Event on data input
     *
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     *
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    public function onInput($data)
    {
        $this->startProcess->input($data, $this);
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    /**
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     *
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     *
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    public function inputFromEndProcess($data)
    {
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    }
}


text:
Dalton Transactions
Potential applications of polyoxometalates for the discrimination of human papillomavirus in different subtypes
Teng Zhang,a Ding-Yi Fu,a Yuqing Wu,*a Yizhan Wanga and Lixin Wu*a
a State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China
E-mail: yqwu@jlu.edu.cn, wulx@jlu.edu.cn
Tel: +86-0431-85168481
The binding-induced luminescence enhancement of an Eu-containing polyoxometalate (POM), EuSiWMo, by the arginin/lysine-rich cationic peptides supplied a platform to detect the capsid proteins of human papillomaviruses (HPVs). However, the strong binding affinity between them makes it very difficult to be differentiated among peptides from different subtypes of HPVs. Therefore, several strategies to monitor the binding affinity of POM-peptide are performed and finally the discriminations on representative peptides from different subtypes of HPV capsid proteins are achieved in the present study. The results show that an Eu-containing POM, EuW10, with nine negative charges is sufficient to discriminate different subtypes of HPV peptides based on the specific sequence and basic charge differences. The discrimination mechanisms between them explored at sub-molecular level using time-resolved fluorescence spectra and isotherm titration calorimetric (ITC) reveal both the driving force and binding model accordingly. Therefore, this study reports a simple, low-cost and efficient fluorescence enhanced method to discriminate the peptides from different subtypes of HPV capsid proteins, which would be possible after further optimization.
Supplementary information PDF (711K)
The article was received on 31 May 2016, accepted on 22 Aug 2016 and first published on 23 Aug 2016
DOI: 10.1039/C6DT02186G
Download Citation: Dalton Trans., 2016,45, 15457-15463
T. Zhang, D. Fu, Y. Wu, Y. Wang and L. Wu, Dalton Trans., 2016, 45, 15457
Teng Zhang
Ding-Yi Fu
Yuqing Wu
Yizhan Wang
Lixin Wu


text:
When I lived in Elko NV a dude flipped out on a Greyhound bus and held a female passenger hostage with nothing but a ballpoint pen to her throat. When he threatened to stab her with it the cops shot him dead.
I didn't know holding a pen was punishable by death.
edit: where was his Dew PROCESS?
edit: where was his DUE PROCESS?
threatening the use of deadly force is justification for the use of deadly force in response, according to just about every local and international law I know of.
Were they doing that?
And like I said earlier, this conveniently overlooks the atrocities carried out at Guantanamo, not to mention all the people cops seem to be killing these days.
I think it's been pointed out that if the same situation happened on American soil, with American citizens, they would have been killed. Get a group of friends together, arm yourself to the teeth, kidnap a couple people, and hold your ground when the authorities come to free them. It's the only way to prove everyone wrong.
And empathy is a good quality to possess, but try to set logical limits, amigo.
Separate the reasonable from the unreasonable. Criticize the unreasonable, accept the reasonable. That's all.
I know dude, maybe you can get that thru to Ray.
I think it's been pointed out that if the same situation happened on American soil, with American citizens, they would have been killed. Get a group of friends together, stem yourself to the teeth, kidnap a couple people, and hold your ground when the authorities come to free them. It's the only way to prove everyone wrong.
But then it's harder to get people to passionately defend the shooting death of another human being.
But I don't know if they were actually doing that or if they had simply asked the hostages to please not run away or else they would be very disappointed.
I'll frame it a little better for you and say no, I don't think it was their intent to kill the hostages. Their intent was to get paid. But that runs up against or philosophy of not buying hostages freedom. So when those two sides meet, do I think there was a resonable possibility, that when push came to shove, they might kill the hostages? The answer is yes. The only leverage someone who takes a hostage has is the other persons life. Is everyone who takes a hostage willing to take that persons life? I don't know. But I don't think it isn't reasonable for law enforcement, or whoever enter the situation with the assumption that they are.
Bottom line, don't hold someone else's life hostage if you yourself aren't willing to give yours up. But that's just kinda how I see it.
Some people deserve to get shot, dude. I would guess there are a handful of situations that would end in you putting a bullet in someone's head, even.
Don't worry Ray, I remember when you were smart.
J. Norbert Klopp
I really wish people tried to understand WHY there's a piracy problem.
I'm having a hard time figuring out why one would defend this particular group, though.
Just this.
first they came for the pirates
And I did not speak up because I am not a pirate
then they came for the terrorists
and I said nothing, because I am not a terrorist
then they were done.
Originally posted by Karl Hungus View Post
99 problems but a pirate aint one.


text:
Yaltormin SR 500mg Prolonged Release Tablets
Wockhardt UK Ltd contact details
metformin hydrochloride
Patient Leaflet
Last updated on emc: 18 Jul 2018
One prolonged release tablet contains 500mg metformin hydrochloride corresponding to 390 mg metformin base.
Prolonged Release Tablets
White to off-white, capsule shaped tablet debossed with 'SR 500' on one side and plain on other side. The tablets are approximately 16.5 mm in length and 8.2 mm in breadth.
Treatment of type 2 diabetes mellitus in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. Yaltormin SR may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin.
Adults with normal renal function (GFR≥ 90mL/min)
Monotherapy in Type 2 diabetes mellitus and combination with other oral antidiabetic agents:
• The usual starting dose is one tablet of Yaltormin SR 500mg once daily.
• After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastro-intestinal tolerability. The maximum recommended dose is 4 tablets daily.
• Dosage increases should be made in increments of 500 mg every 10-15 days, up to a maximum of 2000 mg once daily with the evening meal. If glycaemic control is not achieved on Yaltormin SR 2000 mg once daily, Yaltormin SR 1000 mg twice daily should be considered, with both doses being given with food. If glycaemic control is still not achieved, patients may be switched to standard metformin tablets to a maximum dose of 3000 mg daily.
• In patients already treated with metformin tablets, the starting dose of Yaltormin SR should be equivalent to the daily dose of metformin immediate release tablets. In patients treated with metformin at a dose above 2000 mg daily, switching to Yaltormin SR is not recommended.
• If transfer from another oral antidiabetic agent is intended: discontinue the other agent and initiate Yaltormin SR at the dose indicated above.
Combination with insulin:
Metformin and insulin may be used in combination therapy to achieve better blood glucose control. The usual starting dose of Glucophage SR is one 500 mg tablet once daily, while insulin dosage is adjusted on the basis of blood glucose measurements.
Elderly:
Due to the potential for decreased renal function in elderly subjects, the metformin dosage should be adjusted based on renal function. Regular assessment of renal function is necessary (see section 4.4).
A GFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter. In patients at an increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3 – 6 months.
mL/min)
Total maximum daily dose
Dose reduction may be considered in relation to declining renal function
Factors that may increase the risk of lactic acidosis (see section 4.4) should be reviewed before considering initiation of metformin.
The starting dose is at most half of the maximum dose.
Metformin is contraindicated
Paediatric population:
In the absence of available data, Yaltormin SR should not be used in children.
The tablets should be swallowed whole with a drink of water. They should not be chewed or crushed.
• Hypersensitivity to metformin or to any of the excipients listed in section 6.1
• Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis)
• Diabetic pre-coma
• Severe renal failure (GFR <30mL/min)
• Acute conditions with the potential to alter renal function such as:
- dehydration,
- severe infection,
- shock
• Disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as:
- decompensated heart failure,
- respiratory failure,
- recent myocardial infarction,
• Hepatic insufficiency, acute alcohol intoxication, alcoholism.
Lactic acidosis
Lactic acidosis, a very rare, but serious metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis. Metformin accumulation occurs at acute worsening of renal function and increases the risk of lactic acidosis.
In case of dehydration (severe diarrhoea or vomiting, fever or reduced fluid intake), metformin should be temporarily discontinued and contact with a health care professional is recommended.
Medicinal products that can acutely impair renal function (such as antihypertensives, diuretics and NSAIDs) should be initiated with caution in metformin-treated patients. Other risk factors for lactic acidosis are excessive alcohol intake, hepatic insufficiency, inadequately controlled diabetes, ketosis, prolonged fasting and any conditions associated with hypoxia, as well as concomitant use of medicinal products that may cause lactic acidosis (see sections 4.3 and 4.5).
Patients and/or care-givers should be informed of the risk of lactic acidosis. Lactic acidosis is characterised by acidotic dyspnoea, abdominal pain, muscle cramps, asthenia and hypothermia followed by coma. In case of suspected symptoms, the patient should stop taking metformin and seek immediate medical attention. Diagnostic laboratory findings are decreased blood pH (< 7.35), increased plasma lactate levels (>5 mmol/L) and an increased anion gap and lactate/pyruvate ratio.
Renal function:
GFR should be assessed before treatment initiation and regularly thereafter, see section 4.2. Metformin is contraindicated in patients with GFR<30 mL/min and should be temporarily discontinued in the presence of conditions that alter renal function, see section 4.3.
Cardiac function:
Patients with heart failure are more at risk of hypoxia and renal insufficiency. In patients with stable chronic heart failure, metformin may be used with a regular monitoring of cardiac and renal function.
For patients with acute and unstable heart failure, metformin is contraindicated (see section 4.3).
Administration of iodinated contrast media:
Intravascular administration of iodinated contrast agents may lead to contrast induced nephropathy, resulting in metformin accumulation and an increased risk of lactic acidosis. Metformin should be discontinued prior to or at the time of the imaging procedure and not restarted until at least 48 hours after, provided that renal function has been re-evaluated and found to be stable, see sections 4.2 and 4.5.
Metformin must be discontinued at the time of surgery with general, spinal or epidural anaesthesia. Therapy may be restarted no earlier than 48 hours following surgery or resumption of oral nutrition and provided that renal function has been re-evaluated and found to be stable.
Other precautions:
All patients should continue their diet with a regular distribution of carbohydrate intake during the day. Overweight patients should continue their energy-restricted diet.
The usual laboratory tests for diabetes monitoring should be performed regularly.
Metformin alone never causes hypoglycaemia, although caution is advised when it is used in combination with insulin or other oral antidiabetics (e.g. sulphonylureas or meglitinides).
The tablet shells may be present in the faeces. Patients should be advised that this is normal.
Concomitant use not recommended
Alcohol intoxication is associated with an increased risk of lactic acidosis, particularly in cases of fasting, malnutrition or hepatic impairment.
Iodinated contrast agents
Metformin must be discontinued prior to or at the time of the imaging procedure and not restarted until at least 48 hours after, provided that renal function has been re-evaluated and found to be stable, see sections 4.2 and 4.4.
Combinations requiring precautions for use
Some medicinal products can adversely affect renal function which may increase the risk of lactic acidosis, e.g. NSAIDs, including selective cyclo-oxygenase (COX) II inhibitors, ACE inhibitors, angiotensin II receptor antagonists and diuretics, especially loop diuretics. When starting or using such products in combination with metformin, close monitoring of renal function is necessary.
Medicinal products with intrinsic hyperglycaemic activity (e.g. glucocorticoids (systemic and local routes) and sympathomimetics).
More frequent blood glucose monitoring may be required, especially at the beginning of treatment. If necessary, adjust the metformin dosage during therapy with the other drug and upon its discontinuation.
Organic cation transporters (OCT)
Metformin is a substrate of both transporters OCT1 and OCT 2.
Co-administration of metformin with
• Inhibitors of OCT 1 (such as verapamil) may reduce efficacy of metformin.
• Inducers of OCT 1 (such as rifampicin) may increase gastrointestinal absorption and efficacy of metformin.
• Inhibitors of OCT 2 (such as cimetidine, dolutegravir, ranolazine, trimethoprime, vandetanib, isavuconazole) may decrease the renal elimination of metformin and thus lead to an increase in metformin plasma concentration.
• Inhibitors of both OCT 1 and OCT 2 (such as crizotinib, olaparib) may alter efficacy and renal elimination of metformin.
Caution is therefore advised, especially in patients with renal impairment, when these drugs are co-administered with metformin, as metformin plasma concentration may increase. If needed, dose adjustment of metformin may be considered as OCT inhibitors/inducers may alter the efficacy of metformin.
Uncontrolled diabetes during pregnancy (gestational or permanent) is associated with increased risk of congenital abnormalities and perinatal mortality.
A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital abnormalities. Animal studies do not indicate harmful effects with respect to pregnancy, embryonic or fetal development, parturition or postnatal development (see section 5.3).
When the patient plans to become pregnant and during pregnancy, it is recommended that diabetes is not treated with metformin but insulin be used to maintain blood glucose levels as close to normal as possible to reduce the risk of malformations of the foetus.
Metformin is excreted into human breast milk. No adverse effects were observed in breastfed newborns/infants. However, as only limited data are available, breastfeeding is not recommended during metformin treatment. A decision on whether to discontinue breast-feeding should be made, taking into account the benefit of breast-feeding and the potential risk to adverse effect on the child.
Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately three times the maximum recommended human daily dose based on body surface area comparisons.
Metformin monotherapy does not cause hypoglycaemia and therefore has no effect on the ability to drive or to use machines.
However, patients should be alerted to the risk of hypoglycaemia when metformin is used in combination with other antidiabetic agents (e.g. sulphonylureas, insulin, or meglinitides).
In post marketing data and in controlled clinical studies, adverse event reporting in patients treated with metformin SR was similar in nature and severity to that reported in patients treated with metformin immediate release.
During treatment initiation, the most common adverse reactions are nausea, vomiting, diarrhoea, abdominal pain and loss of appetite, which resolve spontaneously in most cases.
The following adverse reactions may occur with Yaltormin SR.
Frequencies are defined as follows: very common: >1/10; common >1/100, <1/10; uncommon >1/1,000, <1/100; rare >1/10,000, <1/1,000; very rare <1/10,000.
Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Very rare:
• Lactic acidosis (see 4.4. Special warnings and precautions for use).
• Decrease of vitamin B12 absorption with decrease of serum levels during long-term use of metformin. Consideration of such an aetiology is recommended if a patient presents with megaloblastic anaemia.
• Taste disturbance
Very common:
• Gastrointestinal disorders such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite. These undesirable effects occur most frequently during initiation of therapy and resolve spontaneously in most cases. A slow increase of the dose may also improve gastrointestinal tolerability.
Hepatobiliary disorders
• Isolated reports of liver function tests abnormalities or hepatitis resolving upon metformin discontinuation.
• Skin reactions such as erythema, pruritus, urticaria
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
Hypoglycaemia has not been seen with metformin doses of up to 85 g, although lactic acidosis has occurred in such circumstances. High overdose or concomitant risks of metformin may lead to lactic acidosis. Lactic acidosis is a medical emergency and must be treated in hospital. The most effective method to remove lactate and metformin is haemodialysis.
ORAL ANTI-DIABETICS
(A10BA02: Gastrointestinal tract and metabolism)
Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia.
Metformin may act via 3 mechanisms:
• reduction of hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis
• in muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation
• and delay of intestinal glucose absorption.
Metformin stimulates intracellular glycogen synthesis by acting on glycogen synthase.
Metformin increases the transport capacity of all types of membrane glucose transporters (GLUT).
Pharmacodynamic effects
In clinical studies, the major non glycemic effect of metformin is either weight stability or modest weight loss.
In humans, independently of its action on glycaemia, immediate release metformin has favourable effects on lipid metabolism. This has been shown at therapeutic doses in controlled, medium-term or long-term clinical studies: immediate release metformin reduces total cholesterol, LDL cholesterol and triglyceride levels. A similar action has not been demonstrated with the prolonged release formulation, possibly due to the evening administration, and an increase in triglycerides may occur.
Clinical efficacy
The prospective randomised (UKPDS) study has established the long-term benefit of intensive blood glucose control in overweight type 2 diabetic patients treated with immediate release metformin as first-line therapy after diet failure. Analysis of the results for overweight patients treated with metformin after failure of diet alone showed:
• a significant reduction of the absolute risk of any diabetes-related complication in the metformin group (29.8 events/1000 patient-years) versus diet alone (43.3 events/ 1000 patient-years), p=0.0023, and versus the combined sulphonylurea and insulin monotherapy groups (40.1 events/ 1000 patient-years), p=0.0034.
• a significant reduction of the absolute risk of diabetes-related mortality: metformin 7.5 events/1000 patient-years, diet alone 12.7 events/ 1000 patient-years, p=0.017;
• a significant reduction of the absolute risk of overall mortality: metformin 13.5 events/ 1000 patient-years versus diet alone 20.6 events/ 1000 patient-years (p=0.011), and versus the combined sulphonylurea and insulin monotherapy groups 18.9 events/ 1000 patient-years (p=0.021);
• a significant reduction in the absolute risk of myocardial infarction: metformin 11 events/ 1000 patient-years, diet alone 18 events/ 1000 patient-years (p=0.01)
For metformin used as second-line therapy, in combination with a sulphonylurea, benefit regarding clinical outcome has not been shown.
In type 1 diabetes, the combination of metformin and insulin has been used in selected patients, but the clinical benefit of this combination has not been formally established.
After an oral dose of the prolonged release tablet, metformin absorption is significantly delayed compared to the immediate release tablet with a Tmax at 7 hours (Tmax for the immediate release tablet is 2.5 hours).
At steady state, similar to the immediate release formulation, Cmax and AUC are not proportionally increased to the administered dose. The AUC after a single oral administration of 2000mg of metformin prolonged release tablets is similar to that observed after administration of 1000mg of metformin immediate release tablets b.i.d.
Intrasubject variability of Cmax and AUC of metformin prolonged release is comparable to that observed with metformin immediate release tablets.
When the prolonged release tablet is administered in fasting conditions the AUC is decreased by 30% (both Cmax and Tmax are unaffected).
Metformin absorption from the prolonged release formulation is not altered by meal composition.
No accumulation is observed after repeated administration of up to 2000mg of metformin as prolonged release tablets.
Plasma protein binding is negligible. Metformin partitions into erythrocytes. The blood peak is lower than the plasma peak and appears at approximately the same time. The red blood cells most likely represent a secondary compartment of distribution. The mean Vd ranged between 63-276 L.
Metformin is excreted unchanged in the urine. No metabolites have been identified in humans.
Renal clearance of metformin is > 400 ml/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion. Following an oral dose, the apparent terminal elimination half-life is approximately 6.5 hours.
When renal function is impaired, renal clearance is decreased in proportion to that of creatinine and thus the elimination half-life is prolonged, leading to increased levels of metformin in plasma.
Characteristics in specific groups of patients
The available data in subjects with moderate renal insufficiency are scarce and no reliable estimation of the systemic exposure to metformin in this subgroup as compared to subjects with normal renal function could be made. Therefore, the dose adaptation should be made upon clinical efficacy/tolerability considerations (see section 4.2).
Preclinical data reveal no special hazard for humans based on conventional studies on safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity reproduction.
Carmellose sodium
This medicinal product does not require any special storage conditions.
28 and 56 tablets in blister strips composed of aluminium foil and PVC.
Not all pack sizes may be marketed.
No special requirements. Any unused product or waste material should be disposed of in accordance with local requirements.
Wockhardt UK Ltd
Ash Road North
LL13 9UF
Date of first authorisation: 15 March 2016
Ash Road North, Wrexham Industrial Estate, Wrexham, LL13 9UF
www.wockhardt.co.uk


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text:
Kevin Godby
Ames, Iowa, Among America's Smartest Cities
by Kevin Godby
According to a recent Forbes.com article, Ames, Iowa, ranks #2 in the list of cities with the largest percentage of Ph.D.–wielding residents (emphasis mine):
Looking at all metropolitan areas with populations of 50,000 or greater, Ithaca, N.Y. ranks No. 1. Home to Cornell University, a whopping 7.92 percent of residents hold Ph.D.s. Ames, Iowa, where Iowa State University is located, is second, at 7.2 percent. Other university towns round out the top five: In State College, Pa., the figure is 6.04 percent; for Corvallis, Ore., it's 5.63 percent; and in College Station, Texas, it's 5.14 percent.
<wistful thinking>
Someday I may join their ranks—after I write my master's thesis, finish my Ph.D. coursework, and write a dissertation.
</wistful thinking>
There's a Tree in My Driveway
The numbers on offshore oil drilling
Metaplanetary Is the Bomb
Academic Publishing and Open Access
Laptops in the Classroom
Name: Required Email: Required, not published Homepage: Comment:
© Kevin Godby. Powered by WordPress and Manifest


text:
Research team to study childcare in rural Pennsylvania
Harrisburg, Pa. — It's common knowledge that quality child care is a crucial factor in a child's future success in school.
The state's Secretary of Education Gerald Zahorchak has stated, "One of the strongest arguments for quality early education is that it can help children who would otherwise enter school without the necessary skills … bridge the achievement gap before it even begins."
And a recent statewide report by the Pennsylvania Office of Child Development and Early Learning indicates children affected by risk factors such as low-income families are more likely to fail in school. However, the report also indicates these same children can overcome the challenges if they have quality early education experiences before the age of five. The study also noted that only 22 percent of children under five participate in state and/or federally funded high-quality early childhood programs in Pennsylvania.
In an answer to these challenges, Penn State Harrisburg is now a part of a three-college research partnership designed to guide state public policy and budgetary considerations by assessing the quality of childcare available in rural areas of the Commonwealth. These regions many times are underserved and populated by low-income families, making quality childcare out of reach for many parents and potentially slowing progress when a child begins school.
Collaborating with scholars from Lock Haven University and Penn State Altoona, Penn State Harrisburg Associate Professor of Human Development and Family Studies Richard Fiene and Assistant Professor of Education Martha Strickland will be playing key roles in the study funded by a $49,994 grant from the Center for Rural Pennsylvania entitled "Who's Minding the Children in Rural Pennsylvania? A Profile of Regulated Childcare and the Families Using It,"
The scholarly partnership supports Penn State Harrisburg's longstanding commitment to renew academic and research partnerships and develop new ones. As an engaged college and the region's major research university presence, Penn State Harrisburg consistently lends its collective faculty talents through research such as the rural study to significantly improve the economic and cultural well-being of the many communities it serves.
Center for Rural Pennsylvania Director Barry L. Denk says, "In these challenging economic times, affordable and accessible child care is a critical service that many families need in order to seek and maintain employment. The research team from these universities is extremely competent, possessing over 100 years of varied experience in childhood education and family/human development. I am confident their work will result in practical policy considerations for the General Assembly."
Despite the current economic climate, early childhood education drew Gov. Ed Rendell's attention in his proposed budget. Funding of Child Care Works would allow about 2,000 more children from low-income working families to receive child care subsidy. An additional 1,050 at-risk three- and four-year olds would have access to Pennsylvania Pre-K Counts, increasing enrollment to high-quality pre-k through that program to 12,000. And the compromise economic stimulus package working its way through Congress envisions more education for those under five, including universal preschool, increased funding for Head Start, and affordable, high-quality childcare for working families to the tune of $1.4 billion.
Strickland says, "My specialty is immigrant populations and education, but I've developed a passion for early childhood education and as a former elementary education teacher, I recognize the importance of quality early childhood care setting the pace for a child's entire learning career. Although we have some general data, we are looking forward to focusing on the sometimes overlooked rural settings."
Penn State Harrisburg's portion of the research study will be to provide a detailed examination of childcare provider participation in the voluntary STARS program in rural vs. urban areas of the state. "We will look at the problems facing rural centers and parents," Fiene points out.
Steven Hevner
sdh4@psu.edu
http://www.hbg.psu.edu/
Research Unplugged series begins with tips for talking to your teen about sex
Former Beaver student named first Ms. West Indies PSU
Parent information night set for March 27 at Lehman Center in York
Research, Society, Arts and Humanities
child care, education, family studies, Harrisburg, human development
Harrisburg, University Park


A fantastic opportunity to purchase a premium detached three bedroom home. One of only three houses on this small development situated in the sought after village of Keyworth.
One of only three houses on this small private development situated in the heart of Keyworth, 2 minutes from the Village Square. The premium detached homes boast an impressive open plan family living and kitchen area, 3 double bedrooms, in addition to a large rear garden. Making the development ideal for professionals, retirees and families alike.
Each of the three executive detached homes come with a 10 year guarantee and briefly comprise of brick and render facades, open plan kitchen, dining and family area, three bedrooms, ensuite to the master and family bathroom. Swing and slide rear doors, roof Lantern to give extra light to the dining area and anthracite UPVC windows to the front. The rear gardens are also of a generous size as well as parking for two cars at the front all with the convenience of a central village location.
Please note that the measurements and specifications below have been taken from the architect's plans these might vary from the finished properties.
With a panel radiator, two pendant light fittings, Double glazed window to the side elevation, doors leading to the living room, cloakroom and the kitchen/dining/family area. Stairs leading to the first floor with under stair storage.
Low flush WC, pedestal hand wash basin, extractor fan, radiator and window to the side elevation.
Window to the front elevation, pendant light fitting and radiator, tv point.
Kitchen is designed and fitted by La Casa interiors. The fitted kitchen is part of the Hacker classic range with intergrated AEG appliances which include microwave, electric oven, fridge freezer, dishwasher and induction hob. The worktops are laminate with 100mm upstand.
The dining area is lovely and bright thanks to a roof lantern and many spotlights. There is a window to the rear elevation in the kitchen area and swing and slide doors leading out to the landscaped rear garden from the dining area.
The dining area also has mounted flat panel vertical radiators and there are plenty of electrical sockets and tv points in the family area.
Plumbing for washer and dryer, laminate worktop with full bowl sink and mixer tap over, radiator, windowed door to the side elevation.
Obscure window to the side elevation, ceiling light point, doors leading to all three bedrooms and bathroom, boiler storage cupboard.
Window to the rear elevation, radiator, ceiling light point, tv point, access to the en suite.
To contain standard low flush WC, pedestal wash hand basin, enclosed shower unit and towel radiator.
Upgrades optional at an extra cost.
Window to the front elevation, radiator, ceiling light point.
To contain standard low flush WC, pedestal wash hand basin, bath and towel radiator.
Block paved driveway to the front of the property with off road parking for two cars and boundary wall. The rear will provide a generous sized garden which will be mainly laid to lawn with close boarded fencing.