Tristan Roy (managing director, Digital, Canada and Latin America) shares the most valuable skills he's picked up over the course of his professional life and how he has managed to cultivate his passion for creative writing and literature into a valuable skillset for his career.
I had an old boss that used to say "I put things on the internet. Sometimes I take things off the internet, but most of the time I put stuff on the internet." I liked that because, despite the jest, it was something that a child could understand. I suppose the way I most often describe it is that I help companies and organizations tell their story.
I never actually expected to end up in PR, marketing, advertising or digital. I intended to pursue a career or academic life in the arts but wanted to take some time after graduating to travel and try out a few different things. Given my interest in the arts in all forms – written, visual, digital, etc. – doing an internship at a communications agency seemed a logical and fitting pursuit. Once I started at Edelman, I fell in love with the pluralism of the work and the dynamism of the people.
What has been your favorite project you've worked on at Edelman?
I am of the disposition that you have to love all of the work. Whether it is big or small, creative or consultative, or in the face of an opportunity or crisis – you have to love the day-to-day in our business. It is also hard to name a favorite project after 13 years at the agency; there are so many. If I allow a little bit of recency bias, a highlight would be the work we did for HP in Canada with Michael 'MafiaBoy' Calce, a now-reformed cyber-security expert who was once considered one of the top black hat hackers in the world, around print security. It won awards in both Canada and internationally (Cannes and Clio), but most importantly made an impact for our clients.
What do you like most about working at Edelman?
I love our independence and the sense of family. Both of those things are felt tangibly. I also love getting to be an entrepreneur, but doing so within a large global agency full of incredibly smart and dynamic people and amazing clients.
What skills have you picked up along the way that are the most valuable to you today?
I think there are four that help me in nearly all personal and professional contexts. First, life and business are both conducted in the currency of relationships. I've learned to invest in those relationships with empathy. Next, becoming comfortable with and actually metabolized by ambiguity has allowed me to consistently find opportunity in the uncertain complexity of our industry and our world. Third, Jeff Bezos talks about creating the space to make only a few high-quality and high-impact decisions on a daily basis. This speaks to not only the importance of creating room for deep, divergent and strategic thought, but also to the notion of prioritization. I've tried to cultivate a disciplined and filtered approach to what I focus on with the goal of having maximum impact on the items that will make the biggest difference in life or business. Finally, I've worked hard to practice resilience over the course of my life and career. I use the word practice intentionally, similar to the way it is used in yoga or mindfulness. Resilience is a habit, and it is important to practice that habit in the face of setbacks big and small.
What advice would you give to someone who is just starting out in his or her career?
In addition to considering the skills I've mentioned above, I would encourage someone just starting their career not to develop an overly rigid or defined idea of what their career path or trajectory should look like. Most, if not all, of the most rewarding and satisfying experiences and outcomes in my career (and even life) have come as a result of letting myself be open to unforeseen opportunities or circumstances that didn't necessarily fit my view of where my career was going at the time. If I had maintained, in those moments, an overly narrow view of what I should do and where I should be I would have missed out on an awful lot.
What are three things you read or access every day?
The Ringer online, and The Globe and Mail and The Wall Street Journal in print.
What's on your nightstand, playlist or Netflix queue?
I always keep a big stack on my nightstand, so it can be unwieldy. Right now there are biographies of Churchill, Robin Williams and Muhammad Ali, and I always keep texts from the stoics like Marcus Aurelius, Seneca and Epictetus. I typically have a Steinbeck (my favorite American author) on the go. And the latest issue of the Monocle is typically handy, too. In terms of playlist, I am most often listening to jazz or classical crossover. Labels like Blue Note and European label ECM are both ubiquitous on my playlist, as are artists like Max Richter. His eight-hour-plus album Sleep gets a lot of play in the evenings and when I'm on the road.
Focus on the things I can control. Often, the only thing that can be controlled in a situation is your reaction to it.
I try to be a global citizen both personally and professionally, so travel is high on my list. I recently did a trip with my wife to Mongolia (with several nights in the Gobi Desert staying in a traditional Mongolian ger and meeting nomadic families) and Japan.


Okay, to begin with, you have to understand the difference between being a distributor and a dealer. There has been a prevailing confusion regarding the definition of these two. But let us look at them individually.
So first, distributors are those entities who sell products to the retailers or small business owners after acquiring the same from manufacturers. On the other hand, an authorised dealer meets certain requirements for the manufacturer or service provider to sell their respective products. Thus, if you are planning on becoming a distributor, then you probably will have to have a wide clientele to help your business become popular and prevalent.
Fashion is a broad department that includes everything from clothes to footwear, accessories to equipment. Clothes, of all, form the most important sub-division, given that they are a necessity. You will find them everywhere. Men's clothing has gained a lot of momentum in the last few years with many fashion enthusiasts experimenting and introducing new clothing pieces. With the number of stores increasing not only domestically but also on international grounds, there is an increased need of distributing clothes. Also, the efficacious stance of e-commerce which has grown with the rising need of internet, the distributors have got a scope to make their business far-fetched. This automatically increases the opportunity of earning marginal revenues and making excessive profits every annum.
To become a distributor of men's clothing, and a successful one at it, here is presenting a list that follows the step and will answer all your queries and establish your business.
The first step requires you to obtain a license for distributorship in the area you are planning to operate. Whether or not it is profitable to work in that area determines a lot about the future of your work. Also getting a vivid idea and status about the clothing market in the global scene is pivotal.
Next you have to figure out about the manufacturers who are willing to deal with you. Since you will be dealing in bulk products, make sure to secure considerable profit amounts from the producer. Getting hold of top-notch manufacturers will further help you get quality products.
Visit the website of the producers and register yourself with them so as to provide them with the necessary details about your business venture.
Once, you are registered with them, make a dedicated webpage for your own company for that will help both the retailers and manufacturers keep a tab of the products available with you. Advertise well and try to form a strong client base. Associate with both the manufacturers and the store owners for that will help you stay on the top of your game.
Follow the steps as mentioned on how to become a distributor of mens's apparel and you will definitely get the required amount of attention in the competitive world. Good quality and sufficient quantity is the key to emerge on the top of this game.


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The Labidi-Galy Lab – News & Events
17 June 2022 – IRCI 2022 Conference Lyon
Four members of the Labidi-Galy Lab attended the 2022 Immune responses in cancer and infection (IRCI conference) in Lyon. They presented several of the lab's ongoing research projects as poster presentations. Zeinab Dehghani-Ghobadi (PhD candidate) presented a project which attempts to characterise the implications of immune infilitration in endometriosis. Nawel Zouggari (Post Doc) presented the immune evolution during tumour invasion in endometrial adenocarcinoma and Lou Romanens (PhD candidate) presented the role of clonal expansion of intra-epithelial T cells in breast cancer.
9 June 2022 – Major US Ovarian Cancer Research Grant Awarded To PD. DR. Intidhar Labidi-Galy MD. PhD. and Prof. Sven Rottenberg
A prestigious grant from the USA has been awarded to our group leader Intidhar Labidi-Galy and the biomedical scientist Sven Rottenberg, University of Bern. They received a joint grant from the "Congressionally Directed Medical Research Programs" for their project on ovarian cancer. This underlines the high quality of the collaborative research on ovarian cancer in Bern and Geneva.
The Ovarian Cancer Research Program is the only US federal research program dedicated to this deadly disease and among the most prestigious awards for ovarian cancer. It invests in high-impact, cutting-edge research to target the most critical needs along the research development pipeline from basic to translational to clinical research, and supports innovative approaches to move the field forward to their vision of eliminating ovarian cancer.
"This is an extraordinary success as in the past 10 years only one other Ovarian Cancer Research Program award was granted to a European scientist", says Prof. Brigitte Galliot, Vice-Rector for Research at the University of Geneva.
Unfortunately, most women will eventually have a relapse of their cancer and develop resistance to PARPi. Survival of these patients is poor, not exceeding 18 months. "This is why it is urgent to identify the biological mechanisms underlying resistance to PARPi and, based on this knowledge, develop new targeted therapies for our patients that overcome resistance," says Intidhar Labidi-Galy.
To investigate the mechanisms of resistance to PARPi in BRCA-mutated ovarian cancer, the team will apply modern high-throughput approaches that include digital pathology and artificial intelligence, genomics and spatial transcriptomics of biopsies collected from ovarian cancer patients who developed PARPi resistance. The putative mechanisms of resistance to PARPi will be further validated using 3D culture systems of living tumor samples derived from ovarian cancer patients. The overall goal of this research is to provide novel therapeutic strategies to improve the health and well-being of women impacted by drug-resistant ovarian cancer.
22-23 November 2021 – 10th Swiss Cancer Center Leman Staff Retreat
The SCCL – Swiss Cancer Center Léman brings together fundamental, translational and clinical cancer researchers from western Switzerland's most prominent scientific and medical institutions. This annual event is an excellent opportunity for these research groups to come together to share novel cancer research advances and build long lasting relationships and common research interests.
This year, the Labidi-Galy came together to present five of its members' ongoing research projects in poster formats. In doing so, the presenters managed to enjoy sharing their insights and receiving relevant feedback on their projects.

redpajama_set_name: RedPajamaCommonCrawl


text:
El cuarenta y nueve (49) es el número natural que sigue al cuarenta y ocho y precede al cincuenta.

Propiedades matemáticas
 Es un número compuesto, que tiene los siguientes factores propios: 1 y 7.
 Es un pseudoprimo de Somer basado en el 8.
 Es el cuadrado de 7.
Un número semiprimo.

Características
 49 es el número atómico del indio.

Números enteros

redpajama_set_name: RedPajamaWikipedia


After-school chess registration – winter/spring extended.
Please note that the registration deadline for the after-school winter/spring session of chess has been extended to 2/11. Please register soon if you are interested.


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(TGCount Note: This is an archived version of the pool report originally posted at https://publicpool.kinja.com/subject-flotus-pool-report-1-flagler-museum-april-18-1825354509 on 2018-04-18 15:22:00.)
Subject: FLOTUS Pool report #1/ Flagler Museum April 18, 2018
*From:* "Swisher, Skyler" <xxx@sunsentinel.com>
*Date:* April 18, 2018 at 10:30:53 AM EDT
*Subject:* *FLOTUS Pool report #1/ Flagler Museum April 18, 2018*
Pool is awaiting the arrival of first lady Melania Trump and Akie Abe, the wife of Japanese Prime Minister Shinzo Abe, at the Henry Morrison Flagler Museum in Palm Beach.
No remarks are expected from the first lady, a spokeswoman said.
In February 2017, Melania Trump and Akie Abe toured Palm Beach Countys Morikami Museum and Japanese Gardens during the Japanese delegations first visit to Mar-a-Lago.
Here is some background on the museum, according to its website and an application submitted to the National Park Service.
The Henry Morrison Flagler Museum is a Palm Beach landmark on the Intracoastal Waterway a few miles from Mar-a-Lago.
The industrialist Henry Flagler built the 75-room, 100,000-square-foot mansion, Whitehall, for his much younger and third wife, Mary Lily Kenan Flagler. The couple used the home as a winter retreat from 1902 until Flagler's death in 1913, establishing Palm Beach as a Gilded Age destination for the wealthy.
Designed in the neoclassical revival style, the faade is marked by massive marble columns and topped with a red barrel tiled roof. The entryway was intended to be the grandest and largest of the Gilded Age with a 20-foot ceiling and seven varieties of marble.
Most of the first floors large rooms follow French decorative traditions of the 16th through the 18th centuries. The rest of the interior, primarily the second-floor bed chambers and guest rooms, were originally period rooms ranging in style from Louis XIV to Modern American.
A 1902 story that appeared in the New York Herald described Whitehall as, "More wonderful than any palace in Europe, grander and more magnificent than any other private dwelling in the world..."
It cost about $4 million to build and furnish Whitehall at the beginning of the 20th century, which would equate to more than $100 million in today's dollars.
After building a fortune as one of the founders of Standard Oil, Flagler played an integral role in the development of Florida, building a railroad that spanned from Jacksonville to Key West as well as several hotels.
One of the highlights of the museum is Flagler's private railcar No. 91, which was restored and is exhibited in the museum's pavilion.
About 100,000 people visit the museum annually.
Skyler Swisher
Palm Beach County reporter
South Florida Sun Sentinel
(C) 954-xxx-xxxx
(O) 954-xxx-xxxx
Twitter: @SkylerSwisher


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The scope of the problem
The effect of insulin on multiple body systems
Pathophysiology of insulin resistance
A new paradigm
Department of Medicine, Scarborough Hospital, Canada
Amy Berger
Nutrition Institute, University of Bridgeport, United States
Fung J, Berger A. Hyperinsulinemia and Insulin Resistance: Scope of the Problem. Journal of Insulin Resistance. 2016;1(1), a18. http://dx.doi.org/10.4102/jir.v1i1.18
Hyperinsulinemia and Insulin Resistance: Scope of the Problem
Jason Fung, Amy Berger
Copyright: © 2016. The Author(s). Licensee: AOSIS.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
At the beginning of the 20th century, infectious agents were the major causes of disease. The top three causes of death were pneumonia, tuberculosis and gastrointestinal infections. As a result of improved public sanitation and breakthrough developments in antimicrobial agents, these once formidable illnesses are now more rare and easily treated. In the 21st century, acute infectious diseases have been replaced by cardiovascular disease (CVD), cancer and diabetic complications as the most common causes of death.
The explosion of knowledge in genetics led to the discovery of many diseases that resulted from single genetic mutations. However, many modern, non-infectious chronic illnesses – the so-called 'diseases of civilisation' – do not fit the 'one gene, one disease' paradigm. Genetics obviously plays a role in susceptibility to disease, but just as obviously, the meteoric rise of these modern diseases cannot be the result of genetics alone.
Rather than 'unlucky genes', these conditions result from metabolic processes and cellular physiology derailed by poor diet, disrupted circadian rhythms, poor stress management, inadequate physical activity and other parameters by which modern lifestyles may be misaligned with the dietary and environmental landscapes humans are physiologically adapted to.1,2,3 Among these conditions are ailments as diverse as type 2 diabetes (T2D), CVD,4 Alzheimer's disease (AD),5,6,7 acne,8,9 gout,10,11,12 erectile dysfunction,13 polycystic ovarian syndrome (PCOS)14 and conditions that are typically deemed 'idiopathic', such as vertigo and tinnitus.15,16,17 A growing body of evidence suggests that these wide-ranging and seemingly unconnected conditions can, in fact, be linked to a common underlying cause: metabolic derangement resulting primarily from chronic hyperinsulinemia, and its eventual end point, insulin resistance (IR).
Virtually no medical specialty is unaffected by IR. From cardiology to endocrinology, paediatrics, gynaecology, ophthalmology, neurology and more, healthcare practitioners, treating patients from the cradle to the grave, regularly encounter pathological states that result directly from or are exacerbated by IR. However, currently there exists no forum to synthesise and unite the clinical findings and academic research across these diverse specialties. The Journal of Insulin Resistance is the vehicle through which this may be accomplished going forward.
The economic costs associated with IR are staggering. Diabetes-related expenditures totalled $245 billion in 2012, with an increase to $322 billion when factoring in undiagnosed diabetes, pre-diabetes and gestational diabetes.18,19 Costs associated with AD alone are projected to exceed a trillion dollars by 2050, and projections for other illnesses are no less grim.20 The exploding incidences of these conditions – which strike people ever younger – are a matter of national security, and financial security for individual families. Public health authorities, clinicians and patients alike can no longer afford to remain ignorant of the undeniable connections between IR and the wide range of pathological conditions currently causing such extensive morbidity and mortality. A large and continually expanding body of evidence suggests that IR is the cornerstone of a unifying theory of chronic disease.21
Hyperinsulinemia and IR are primary underlying factors either causing or exacerbating the illnesses that will bankrupt entire nations. A new treatment paradigm – which is quite different from the one currently employed – is urgently needed.
The problems of hyperinsulinemia and IR are far greater than what is currently recognised in both the medical literature and clinical practice. While IR is rarely discussed outside the context of T2D, millions of pre-diabetics and even non-diabetics remain at high risk. This reflects the limitations of a formal diagnosis of T2D based solely on abnormal blood glucose measurements. These include elevated fasting blood glucose (FBG), elevated haemoglobin A1c (HbA1c) and an abnormal response to an oral glucose tolerance test (OGTT).22 The narrow focus on blood glucose dynamics ignores the larger and more insidious factor in the development of T2D and other epidemic diseases of the modern world: chronically elevated insulin.
Dr J. Kraft and colleagues discovered a staggering number of individuals with impaired insulin sensitivity missed by the traditional 2-h OGTT. Extending the OGTT to 5 h and including an insulin assay demonstrated that few individuals had truly healthy blood glucose and insulin responses.23 The vast majority exhibited these 'normal' markers only as a result of dramatically elevated insulin.23,24 Pathologically high insulin levels were keeping blood glucose within normal limits, leaving physicians with a false sense of safety regarding the true metabolic health of these patients.
Hyperinsulinemia or IR, rather than hyperglycaemia, may play the largest causal role in the pathology and progression of the modern chronic diseases. Elevated FBG and HbA1c are late indicators of metabolic dysregulation. It may be that the pancreas maintains its ability to secrete inordinate amounts of insulin, and muscle and adipose tissue remain sensitive to those elevated amounts for years, possibly decades, before breakdowns in physiology occur and the manifestation of hyperglycaemia becomes evident.
Therefore, normoglycaemic individuals are still at significant risk for the myriad conditions related to IR and resulting metabolic derangement. Family physicians are typically a patient's first point of contact with the medical system, and therefore may be in a position to identify insulin dysregulation in its earliest phases. However, direct measurement of fasting or post-prandial insulin levels is not currently a standard practice among these clinicians. In the absence of insulin testing, other parameters strongly suggest the presence of IR. These signs and symptoms overlap with those of metabolic syndrome (MetSy), which is regarded as a condition of IR and carbohydrate intolerance.25,26,27 They include the following: decreased high-density lipoprotein cholesterol (HDL-C), large waist circumference, hypertension, elevated triglycerides and elevated FBG.28 Other markers that may add to the clinical picture include elevated homeostatic model assessment of insulin resistance (HOMA-IR),29 low-density lipoprotein (LDL) particles skewed towards small, dense 'pattern B',30 elevated C-reactive protein31 and elevated liver enzymes.32
Although obesity, as measured by body mass index (BMI), is one of the biggest risk factors associated with development of MetSy, patients with a 'healthy' BMI are not immune to the effects of insulin dysregulation. BMI is a useful metric in the epidemiologic assessment of entire populations, but it is far less accurate an indicator of the metabolic status of individuals. Heavier individuals with physiological markers that fall well within normal ranges are classified as the 'metabolically healthy obese',33 while the converse of this – individuals with a healthy BMI, but several markers that place them squarely in a diagnosis of MetSy – are referred to as the 'normal weight obese'.34,35
Body weight is an unreliable indicator of current health and future disease risk, as normal-weight metabolic syndrome patients are at greater risk for morbidity and mortality than overweight individuals free of metabolic derangement.36,37 For too long, overweight and obesity have been considered primary drivers of diabetes, heart disease, inflammatory disorders, etc., despite the fact that there are millions of normal-weight individuals who experience these conditions.
The accumulation of excess adipose tissue may be the result, rather than the cause, of the same underlying insulin dysregulation central to the development of the metabolic syndrome. This may help explain why some individuals develop obesity while others do not, because obesity may be only one manifestation of IR, albeit the most outwardly obvious. People may exhibit other manifestations of IR even in the absence of excess adiposity. Increased abdominal circumference and a large waist-to-height ratio are indirect indicators of IR.38
Moving beyond BMI and anthropometric measurements, even across the entire spectrum of body weight, chronically elevated insulin is associated with – and may be a primary driver of – the dominant health scourges of our time: CVD, cancer and AD. These pathologies may be present even in the absence of chronic hyperglycaemia, although the combination of IR with hyperglycaemia greatly compounds the effects.
The extent to which CVD is a manifestation of IR is greatly underappreciated. In a Japanese cohort of non-diabetic individuals aged 46–80 years old free of CVD (n = 29 059), followed for a median of 9.4 years, 935 CVD events were recorded (770 strokes and 165 coronary heart disease). After adjustment, a non-linear association was observed between HbA1c levels and CVD risk. Compared with HbA1c levels of 5.0% – 5.4%, the hazard ratio (HR) for CVD was 1.77 (95% CI: 1.32–2.38) for HbA1c levels ³ 6.5%.39 These findings echo those of other studies. Elevated HbA1c within the non-diabetic range is an independent risk factor for CVD – in particular, ischemic stroke and coronary heart disease.40 With emphasis again on non-diabetics, the continuous and significant association between elevated A1c persists independent of age, BMI, waist-to-hip ratio, systolic blood pressure, serum cholesterol and smoking. In a British cohort (n = 10 232, 4662 men and 5570 women), excluding individuals with a history of CVD or HbA1c > 7.0%, diagnosed diabetics accounted for 15.0% of the deaths in the sample, compared to 72.0% occurring in individuals with HbA1c between 5.0% and 6.9%.41 With elevated HbA1c not prompting a formal diabetes diagnosis until it exceeds 6.5%,42 it's clear that increased risk for CVD may be missed for millions of people with HbA1c within the normal or pre-diabetic ranges, and who would otherwise be classified as 'apparently healthy'.43
Cancer, too, has undeniable associations with IR. Cancer cells, regardless of tissue type, are characterised by aberrant glycolytic metabolism. Cancer cells have mitochondria that are reduced in number, function or both. Thus, they are unable to generate ATP efficiently via oxidative phosphorylation and instead revert to rampant glycolysis and a more primitive form of energy generation: 'aerobic fermentation' – fermentation even in the presence of oxygen, known as the Warburg effect.44,45,46,47 With significant impairment in cancer cells' capacity to oxidise fatty acids and ketones, IR and chronic hyperglycaemia provide cancer cells with a large and continuous supply of the fuel substrate they metabolise most effectively: glucose.48
In addition, chronic hyperinsulinemia may promote carcinogenesis via stimulation of insulin-like growth factor 1 (IGF-1), modulation of sex hormones and through promotion of inflammation.49 Beyond an increased incidence of cancer, IR and elevated HbA1c are also correlated with worse prognosis in patients undergoing active treatment.49,50 Even within the normal range, HbA1c is positively correlated to an increased risk for all cancers (excluding that of the liver), which mirrors the increased risk for CVD.51 Metabolic syndrome, IR and hyperglycaemia are all associated with breast cancer recurrence, which has many oncologists and dietitians calling current dietary guidelines into question.52
AD is now frequently referred to as 'diabetes of the brain' or 'type 3 diabetes', bringing immediate attention to the role of insulin dysregulation and impaired blood glucose.53,54 A wealth of research implicates brain IR in the pathology and progression of this condition.55,56 Indeed, elevated HbA1c is a strong risk factor for greater progression of brain atrophy among the elderly.57 Even among non-diabetics, the risk for future cognitive decline is positively associated with higher fasting insulin levels and HOMA-IR at baseline.58 Among a cohort of individuals aged 65 or older without dementia, the risk for developing AD was double among non-diabetics with fasting hyperinsulinemia compared to those with normal fasting insulin levels.59 These are individuals whose increased risk for cognitive impairment and AD would be missed by standard blood testing looking only at fasting glucose and A1c.
There are multiple mechanisms through which the pathophysiological cascade initiated by IR may be responsible for the development of such seemingly disparate conditions as T2D, CVD, AD and male and female reproductive abnormalities.
Hyperglycaemia leads to pathologic protein glycation, which may compromise the function of multiple organs and tissue systems, including the eyes, kidneys, blood vessels, peripheral nerves and the blood itself.60,61,62 This is most clearly demonstrated by HbA1c and fructosamine measurements.
As an anabolic hormone, insulin plays a key role in fuel partitioning and metabolism. Abnormalities of insulin regulation may lead to an overloading of fuel substrates into the mitochondria. The resulting oxidative stress leads to eventual mitochondrial dysfunction or destruction, which has been implicated in the pathology or progression of conditions not typically associated with IR, such as multiple sclerosis,63,64,65 AD,66,67 Parkinson's disease68,69 and cancer.44,70
Chronic hyperinsulinemia may promote systemic inflammation,71 in part by influencing desaturase enzymes involved in the inflammatory process (via catalysing the conversion of omega-6 linoleic acid into inflammatory prostaglandins and other signalling molecules).72 Chronic, unresolved inflammation and oxidative stress are increasingly recognised as underlying factors in atherosclerosis and other forms of heart disease.4,73
Insulin profoundly influences sodium and fluid dynamics, and therefore may play a role in idiopathic hypertension even in the absence of other signs of MetSy. Hyperinsulinemia, compounded with hyperglycaemic glycation of the fragile renal tubules, results in overall fluid retention, manifesting as oedema.10,74
Insulin influences sex hormone dynamics in both men and women by upregulating expression of the aromatase enzyme, responsible for converting testosterone into oestrogen. This may partially underlie the increasing incidence of gynaecomastia, prostatic hypertrophy or hyperplasia, decreased libido and general sexual dysfunction in men.75 In women, PCOS has long been recognised as a hyperinsulinemic condition that frequently manifests along with increased androgens, resulting in hirsutism and other signs of masculinisation, as well as menstrual abnormalities and infertility.76,77,78
Several theories have been put forward regarding the development of IR. There is likely not a single cause, rather a confluence of factors that exert their influence over time and eventually result in metabolic dysregulation. These include, but are not limited to, the following:
excessively high refined carbohydrates in the diet, resulting in a glycaemic load that overwhelms human physiological regulatory mechanisms79,80
biologically inappropriate amounts of polyunsaturated fatty acids (specifically, omega-6 linoleic acid, coming primarily from isolated vegetable and seed oils, such as soy, corn and cottonseed)73,81
insufficient dietary omega-3 fatty acids, particularly when coupled with excessive intake of omega-6 fatty acids82,83,84,85,86,87
disrupted circadian rhythms and an extended photoperiod, which may have an adverse influence on internal biorhythms and the pulsatile secretion of hormones, including cortisol and human growth hormone88,89,90,91
reduced physical activity, affecting mitochondrial biogenesis, skeletal muscle glucose uptake and insulin sensitivity92,93,94,95,96
increased feeding opportunities – decreased time between meals, allowing less time for a return to baseline in hormones that regulate blood glucose, appetite and fuel partitioning, such as insulin, glucagon and leptin, and reduced time for autophagy and cellular repair.97,98,99
This is but a small selection of the host of factors purported to contribute to the development of IR. There may be many more. The Journal of Insulin Resistance will be a forum for highlighting new findings related to these and yet-to-emerge theories regarding the aetiology, treatment and prevention of IR.
Modern medicine remains mired in a myopic and outdated paradigm of searching for a single pathogenic cause for each separate illness encountered – a one-to-one match, like a key fitting into a lock. Researchers and clinicians continuously look for 'silver bullet' cures for the various modern diseases. This approach worked well for infectious diseases caused by pathogenic organisms, but it is clearly failing to have an impact on the current epidemic of metabolic diseases, which are not infectious in origin.
Instead, understanding that many modern diseases are dietary and environmental in nature leads us to the inescapable and logical conclusion that the solutions are to be found in dietary and lifestyle interventions.
Virtually, no body system is unaffected by chronic hyperinsulinemia, IR and the accompanying hyperglycaemia. Therefore, the time has come for a new paradigm, recognising the primacy of insulin dysregulation as a unifying factor of chronic disease. As the various diseases associated with the MetSy may be relatively late indicators of IR that manifest only after the body's compensatory mechanisms have begun to fail, then early identification may be one of the most powerful and profound tools for modern medicine in stemming the destructive tide of these illnesses.
By addressing hyperinsulinemia and IR, it is possible to treat the root cause, rather than the symptoms, of these myriad diverse conditions. Symptomatic treatment alone leads to disease progression, necessitating ever higher doses and new forms of medication, as well as expensive surgical procedures. By potentially obviating the need for pharmaceutical drugs that are ineffectual at influencing the underlying cause(s) of these illnesses, this new paradigm may reduce the inherent dangers of polypharmacy and the incidence of undesirable and often harmful side effects of medication prescribed to ameliorate the effects of other medication.
Indeed, patients are typically told their chronic illnesses are progressive and irreversible. It may be, however, that this prognosis is accurate only insofar as it reflects the current symptom-oriented treatment paradigm. Alternatively, if treatment is reoriented towards correcting the primary underlying metabolic disturbances, then patients may be motivated to take a more proactive role in their own care and it may well be possible to reverse these so-called 'diseases of civilisation'.
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text:
Biografia
Orfano in tenera età, conduce un'infanzia da film neorealista, vivendo per strada e facendo le cose più diverse per sopravvivere. Trasferitosi a Teheran, già da adolescente si avvicina al mondo della fotografia e del cinema, lavorando per quotidiani e riviste e facendo il fotografo di scena e l'assistente alla regia. Tra il 1972 e il 1988 realizza undici film in Iran, partendo da formule convenzionali per approdare ad un cinema sempre più visionario e anti-narrativo.

Alla fine degli anni ottanta si trasferisce negli Stati Uniti d'America, a New York, dove si dedica sia al cinema (inserendosi nell'ambiente del cinema indipendente americano) che alla fotografia (New York City 1997 Frescoes).

A, B, C... Manhattan è stato presentato al Festival di Cannes 1997, nella sezione Un Certain Regard. Marathon - Enigma a Manhattan è stato presentato al Torino Film Festival 2002 ed è il suo primo film ad avere avuto una distribuzione cinematografica in Italia, dove i suoi film precedenti sono stati visti solo nel programma Fuori orario di Rai 3. Anche il successivo Sound Barrier (2005) è stato presentato, fuori concorso, al festival torinese.

Nel 2006 il Museo nazionale del cinema di Torino gli ha dedicato una retrospettiva completa ed ha presentato la mostra fotografica intitolata Bullshit Walks Money Talks. Attraversando Las Vegas, nata dall'interesse per Las Vegas e da un progetto di film non ancora realizzato.

Nel 2008 ha presentato in concorso alla 65ª Mostra del cinema di Venezia Vegas: Based on a True Story con Nancy La Scala.

Filmografia

Regista
Khodâ hâfez rafiq (1972)
Saz-e dahani (1973)
Tangsir (1973)
Tangnâ (1973)
Entezar (1974)
Marsiyeh (1976)
Sâkt-e Irân, Sâkt-e America (1978)
Jostoju 1 (1980)
Jostoju 2 (1982)
Il corridore (Davandeh) (1985)
Acqua, vento, sabbia (Ab, bâd, khâk) (1988)
Manhattan by Numbers (1993)
A, B, C... Manhattan (A, B, C... Manhattan) (1997)
Marathon - Enigma a Manhattan (Marathon) (2002)
Sound Barrier (2005)
Vegas: Based on a True Story (2008)
Cut (2011)
Mise en scène with Arthur Penn (a conversation) - documentario (2014)
Monte (2016)
Magic Lantern (2018)

Produttore
The Neighbor (Hamseyeh), regia di Naghmeh Shirkhan (2010)

Note

Bibliografia

Altri progetti

Collegamenti esterni

Naderi


text:
Q: How does this sorting algorithm function? I was looking for a sorting algorithm and found the following which does the work. Yet I don't understand what does the first part do? Thanks for your help/comments!
public static void reorder (Animal[] types) {
      int i = 0, j;                   //From here
      for (Animal type : types)
         if (type.ordinal() > 0)
            i++;                      //to here
      for (j = 0; j < i; j++)
         types[j] = Animal.rabbit;
      for (i = j; i < balls.length; i++)
         types[i] = Animal.fox;

A: The class Animal has an ordinal() method, not sure what that method does but the section of code you refer to does:

*

*Iterate the types array

*If the invocation of the method ordinal() on each element is greater than 0

*

*Then it increases the counter i in by 1

And that's it really.

redpajama_set_name: RedPajamaStackExchange


text:
Die evangelisch-lutherische denkmalgeschützte Kirche St. Benedikt steht an der Hauptstraße auf einem schwach erhöhten Plateau im nordöstlichen Teil des Dorfes Westerengel, einem Ortsteil der Stadt und Landgemeinde Greußen im Kyffhäuserkreis in Thüringen. Die Kirchengemeinde Westerengel gehört zum Pfarrbereich Greußen im Kirchenkreis Bad Frankenhausen-Sondershausen der Evangelischen Kirche in Mitteldeutschland.

Beschreibung
Die aus Bruchsteinen errichtete Saalkirche hat einen bündig anschließenden querrechteckigen Kirchturm im Osten. Vom romanischen Vorgängerbau aus der ersten Hälfte des 13. Jahrhunderts blieben der Turm und Teile des Kirchenschiffs erhalten. Das Kirchenschiff wurde 1822 abgebrochen und unter Verwendung des alten Baumaterials neu errichtet. Der Fassade im Osten war ursprünglich ein Chor vorgelagert, zu erkennen am zugemauerten Chorbogen. Die beiden spitzen schiefergedeckten achtseitigen Zeltdächer des Turms wurden 1516 errichtet. In der Glockenstube befindet sich ein Glockenstuhl aus Eichenholz mit drei Kirchenglocken, die kleinste aus Bronze wurde 1892 von einer Glockengießerei in Apolda, die beiden Eisenhartgussglocken wurden 1956 von Schilling & Lattermann gegossen.

1822 erfolgte ein grundlegender Umbau des Kirchenschiffs, verbunden mit einer Neuausstattung des Innenraums. 1970 wurde das Satteldach des Kirchenschiffs durch ein Mansarddach mit Dachgauben ersetzt. Der Turm hat im Süden und Norden in gleicher Höhe je eine rundbogige Klangarkade, im Süden darunter das Zifferblatt der Turmuhr. Der Turm endet in zwei quadratischen Aufsätzen, zwischen denen sich ein Glockenturm mit Stundenglocke und Wetterfahne befindet. Die Mauern des Kirchenschiffs sind an den Langseiten von je drei hohen Bogenfenstern durchbrochen.

Der Innenraum hat zweigeschossige, dreiseitige Emporen und einen bauzeitlichen Kanzelaltar, der den Bereich zwischen den Emporen ausfüllt. Der Mittelraum wird von einem hölzernen Tonnengewölbe überspannt. Der Aufgang zu den Emporen liegt in der Südwestecke. Das querrechteckige Erdgeschoss des Turms hat ein steinernes Tonnengewölbe. Im Turm befinden sich zwei Flügel eines Altarretabels mit je drei Schnitzfiguren vom Ende des 15. Jahrhunderts.

Auf der Orgelempore an der Westseite steht die von Maul in Greußen 1877 erbaute Orgel, die das von Johann Philipp Schimpf 1821/1822 gefertigte Instrument ersetzte. Sie hat 13 Register, verteilt auf ein Manual und Pedal.

Literatur
 Dehio-Handbuch der deutschen Kunstdenkmäler, Thüringen. Deutscher Kunstverlag, München/Berlin 2003, ISBN 3-422-03095-6, S. 1370.

Weblinks

Einzelnachweise

Westerengel
Westerengel
Bauwerk aus Stein
Erbaut im 17. Jahrhundert
Kulturdenkmal in Greußen
Westerengel
Westerengel
Westerengel


HyperDeck Extreme Control extends your HyperDeck Extreme to add traditional broadcast deck controls. It works like a traditional broadcast deck with a familiar layout. You can control up to 8 decks via industry standard RS‑422 control.
You can even rack mount to the HyperDeck Extreme to create a single "broadcast deck" unit. Because it uses standard RS‑422, you can control old broadcast decks and perform edits using set in and out points. That's perfect for archiving work. Plus you can even edit between frame rates if standards converting between formats. Even the controls have been developed in-house by Blackmagic Design to ensure a premium feel with traditional styling.


There's no way jumping into each other repeatedly could ever get old! Makes for a super fun outdoor game for the kids.
Make a boring game of soccer more interesting by making all players wear these inflatable suits.


Who hasn't been moved by the sight of a turtle plodding slowly across the road, patiently following its course but oblivious to the danger all around it?
Now imagine twenty baby turtles clambering over a grassy yard in danger, not from cars, but from the lawn mower. This was the situation that faced Creature Control technician Dave Mullins when he showed up for a routine bait station restock in Okemos.
As Dave went about his work restocking bait stations, he noticed a baby turtle crossing the customer's driveway. The customer was out mowing her lawn – and the baby turtle was heading right for the mower!
Dave scooped up the baby turtle, but upon closer inspection noticed that the grass and mulch along the driveway was alive with movement. He started digging around and found not one or two but a total of twenty baby turtles all making their way through the grass, heading straight towards the lawn mower.
Dave flagged down the customer and had her shut down the lawn mower. He showed her the baby turtles and spent some time collecting them all. The customer brought a tub out for Dave to keep all the turtles in. She was delighted that Dave had noticed them and removed from the yard, saving them from inevitable doom had they continued on towards the mower.
After posing for some pics with the little family, Dave relocated the turtles to the Harris Nature Center in Meridian Township, which has a lot of great acreage along the Red Cedar River perfect for these little snappers.
All our technicians are trained in the trapping and removal of adult snappers, as well. If you have an adult snapping turtle that is a nuisance in your pond or stream and would like it live trapped and relocated, contact us for a consultation – or click here to read up on snapping turtle biology and habits.
This entry was posted in Animals, Environment and tagged turtles. Bookmark the permalink.


So. I had this grand plan of writing about a woman, or group of women, a day for Women's History Month. But then it decided to snow. And I got stuck in Heathrow…. For five days. Without any of my notes. Or resources. Or computer.
That'll teach me to leave my work at home.
So instead, I'm starting from today: one month, one post a day, about a woman, or group of women (real or mythological) who contributed in some way, however small, to beer history. As I am doing a post a day, these won't be as long, or detailed, as my previous work. Instead, expect these to range between 200-500 words.
If this is an entirely new post, and not something I have previously examined in some way, I will certainly revisit these with more in depth, context, and close analysis later. If you have posts you would like me to return to first, let me know!
Happy International Women's Day! A shout out to all the amazing women currently crushing it in the beer industry! And massive thank you to all those out there fighting to make the beer world a more diverse and inclusive place.
But also a call to remember all those phenomenal women that enabled us to be in the position we are today. While the beer world still certainly has quite a ways to go in terms of inclusivity (for gender, race, class, to name a few), we would not have made it to where we are without the sacrifices and activism of women in the past. And so, in that vein, I want to highlight the story of a group of protestors who paved the way for women to be able to *gasp* drink pints in pubs in Ireland.
To set the stage a bit.
Prior to quite recently, Irish pubs, as Kevin Kearns argued, were male dominated arenas; spaces where many women would dare not enter for fear of being ostracized, or also because they were *literally barred* from coming into the 'male only' public house. There were a few exceptions, but generally women did not enter this space. Instead, women went to Spirit Grocers, open from 1791-1910. And even after their closure, women's entry into the pub was still viewed with disdain, or even forbidden entirely.
While after World War II change began, and women continued to demand entry, it was still a widespread issue. And it was especially considered taboo for a woman to consume a pint of beer in these pubs. In fact, many refused to serve them to women. Particularly those without a male chaperone. Legally.
A founding member of the Irish Women's Liberation Movement, in the early years of the 1970's McCafferty led a group of women to a Dublin pub. Here, they ordered the socially acceptable drink of brandy, and after it was served, proceeded to order a pint of Guinness.
Which they were flatly refused. Refused on the account of them being women, and most especially because it was a pint. They drank their brandy, refused to pay and walked out.
It was acts like this that drew attention to this horrendous practice and helped pave the way for women to happily consume their pints in pubs across the nation. However, it wasn't until 2000 (!!!) that the Equal Status Act barred this sort of sexist discrimination.
Though it is clear that some remnants of the disgust of the female pint drinker remain, (as I, unfortunately, can personally attest to) pubs across Dublin, and especially craft beer ones, are generally places where people of all genders are welcome. To drink pints.
So, as I am off to Alltech Craft Brews and Food Fair tonight, I will be thinking of all the women who have protested, fought and struggled for equality, and continue to do so. Not just in the beer industry, but in all aspects, and I will be raising a *pint* in their honour.
 Kevin Kearns, Dublin Pub Life and Lore: An Oral History (Dublin, 2004), p.17.


text:
Amanda Batchelor, Senior Digital Editor
Published: October 2, 2018, 2:33 pm
Tags: Local, News, Hollywood
Pedestrian struck by freight train in Hollywood
HOLLYWOOD, Fla. – A pedestrian was struck by a freight train Tuesday afternoon in Hollywood, authorities confirmed.
The incident was reported on the tracks in the area of South Dixie Highway and Plunkett Street.
Authorities did not immediately confirm the victim's condition, but Sky 10 was above the scene shortly after 2:15 p.m. as a tarp appeared to be covering the body.
No other details were immediately released.
Amanda Batchelor
Amanda Batchelor is senior digital editor for Local10.com.


text:
Home » Turkey to build wall on Syrian border amid upsurge in violence
Turkey to build wall on Syrian border amid upsurge in violence
Journal of Turkish Weekly;8/3/2015, p1
The article reports on construction of a wall by Turkish Armed Forces on Syrian border to stop illegal border crossings and smuggling between Turkey and Syria. It mentions the plans to add close circuit cameras along the Syrian border. It include comments from Deputy Prime Minister Bülent Arınç on the effort to block terrorists of Islamic State of Iraq and the Levant (ISIL) organization.
Turkey: Police detain 4 in Ankara anti-terror raids. // Journal of Turkish Weekly;8/3/2015, p1
The article reports on detention of suspects in Ankara, Turkey by Turkish Security forces as part of their anti-terrorist operations in the country. It mentions that it is suspected that they belong to terrorist organizations Daesh and Kurdistan Workers' Party (PKK). It include comments from...
7 Soldiers Killed In Iskenderun, Arinc Says. A. A. // Journal of Turkish Weekly;5/31/2010, p3
The article reports on a terrorist attack against Turkish soldiers in the town of Iskenderun, and the comments of Turkey's Deputy Prime Minister Bulent Arinc.
More than 1,300 arrested in Turkish police sweep. // Journal of Turkish Weekly;8/3/2015, p1
The article reports on custody of more than 1,300 people by Turkish police as part of counterterrorism operations across Turkey revealed by Turkish Deputy Prime Minister Bulent Arinc. Topics discussed include detention of people who were suspected supporters of terrorist group Daesh, Kurdish and...
Turkey's Struggle Against the Foreign Terrorist Fighters of DAESH. YALÇINKAYA, Haldun // Perceptions: Journal of International Affairs;Spring2016, Vol. 21 Issue 1, p27
DAESH is a terrorist organisation with a Salafist jihadist ideology that threatens the civilized world. Moreover, like a contagious agent of a cancer cell to the rest of the body, the foreign terrorist fighters of DAESH are a growing threat against their states of origin, the states they...
Qatar voices support for Turkey security measures. // Journal of Turkish Weekly;8/3/2015, p1
The article reports on declaration of support from the Qatari government for counterterrorism measures adopted by Turkish government. Topics discussed include aim of counterterrorism measures for protecting its borders and national security, statement of the Qatar's Foreign Ministry about the...
Police on alert to find three ISIL militants in Turkey after new attacks. // Journal of Turkish Weekly;3/22/2016, p74
The article reports on the alert status of counter-terrorism and intelligence police officers in Turkey as three members of the terrorist group Islamic State in Iraq and the Levant (ISIL) are said to have been ordered to carry out attacks across the country.
Turkey to fly surveillance balloons, build new fence and moat for border security. Erkuþ, Sevil // Journal of Turkish Weekly;7/27/2015, p78
The article reports the plans by Turkey as of late July 2015 to use surveillance balloons and construct a two-fenced border system with a new moat to improve border security with Syria. According to Deputy Prime Minister Bülent Arýnç the aim of the plans is to block the terrorists'...
Security forces conduct anti-terror operations in Turkey. // Journal of Turkish Weekly;8/17/2015, p40
The article reports on anti-terror operations conducted by Turkish security forces in several Turkish provinces including Istanbul, Ankara and Izmir in August 2015, in which at least 44 people were detained. Topics discussed include the bombing and later deadly attacks on security forces that...
Biggest probe into ISIL in Turkey completed. // Journal of Turkish Weekly;12/22/2015, p7
The article announces the completion of Turkey's investigation into the presence of the terrorist group Islamic State of Iraq and the Levant (ISIL) in the country. Topics discussed include the number of ISIL-linked suspects who have been blacklisted, the arrest of ISIL leader Halis Bayancuk, and...


A reissue of a classic 64 Zoo Lane story. Kevin the Crocodile is part of this bestselling series that has sold over 350,000 copies. The fourth 64 Zoo Lane TV series is out now!
Perfect for preschool children, 64 Zoo Lane had the highest viewing figures on CBeebies in 2011 and the 4th series is out now! With six classic 64 Zoo Lane stories now reissued, Lucy and her animal fans are bound to win yet more young fans.


text:
Q: Joining contents of 2 columns How do I join the content of two columns for the resulting column below:
Group:         Family:
polychaete     spionidae
gastropod      rossoidae
foraminifera   rotaliidae
polychaete     magelonidae

result needed:
Taxa:
polychaete_spionidae
gastropod_rossoidae
foraminifera_rotaliidae
polychaete_magelonidae

A: In ANSI SQL, we can use the concatenation operator ||:
SELECT "Group" || '_' || Family AS Taxa
FROM yourTable;

This would vary depending on the database.  For instance, SQL Server uses + as the concatenation operator.  Some databases have formal concatenation functions.
By the way, you should avoid naming your columns using SQL keywords like Group.


text:
Top 10 Music Acts I Just Can't Stand
I need to start this post off with an apology. I'm likely going to tick a couple people off with this update. However, what I present here is just my opinion. And you know what they say about opinions...
As big of a music fan that I am, there are definitely some bands/artists that just rub me the wrong way, and regardless of how I try, I simply cannot enjoy their music. It's not necessarily genre-based - I have likes in every genre, even if they are few and far in between in genres like rap and pop. It's really hard to pin down - it's almost at the artist level, and each of them have rubbed me the wrong way for some reason or the other.
Hence, I thought it worthy of analysis to review the top 10 popular music acts that I just can't stomach. I've ranked them in relative order of worldwide records sold, starting low to high.
10) Barenaked Ladies - I don't like campy or cute, and it seems like everything that this groups has done that's gained success has way, way crossed that line. If I Had $1,000,000 is near torture. Their library may be filled with things of other substance, but I can't endure getting past their popular crap to deal with it.
9) Jack Johnson - He's on of those artist where it seems that every song sounds exactly like the other - the minute a Jack Johnson song hits the radio, you KNOW it is a Jack Johnson song. Bubble Toes remains one of the worst songs written. Ever.
8) Alanis Morissette - I have to admit that I was taken the first time I heard You Ought to Know . It was raw, emotional, and edgy. But Alanis soon became completely overexposed, and the depth that You Ought to Know promised was revealed to be a mirage. She earned bonus loathe points with me by penning the song Ironic that has absolutely nothing to do with irony. She made a mint off of it, and helped hundreds of thousands of teenagers (and ultimately adults) misuse the meaning of the word "irony" every since.
7) The Guess Who - This group has numerous hits. And I hate every one worse than the other. Special hate points go out to Undone and These Eyes . Torture.
6) Janice Joplin - I probably am doing Janice a disservice as I really should dig into her deeper body of work. I just can't get past the Pearl album, and I can't get past the mythology that has been created around her. Had I live through the '60's, I'm quite sure that I would feel very differently about her and her music. But for me, I just cannot find a way to dig her. Not at all.
5) Katy Perry - I think I said all I need to say about Ms. Perry right here.
4) Dave Matthews Band - Unique sound. Innovative, if not brilliant, musician. Massive body of original work. And for whatever reason, I don't like any of it. Occasionally he'll produce a song that resonates with me, and I'll put in into rotation. Last one to hit me was The Space Between . However, by less than 10 listens, I just can't take any more, and I'll delete it off of the hard drive. I want to like him as I respect him as an artist. But for my ear, I just can't handle him.
3) Pearl Jam - I have mixed feelings on this band. Nearly everything they've done has been a total miss with me. But then I absolutely love State of Love and Trust . But then some of what they've done has been complete crap, like Last Kiss (would Nirvana or Alice in Chains, both "peers" of this band, ever done anything like that? No way). And everything in the middle does nothing for me. Throw in their political activism, and I've got very little time for this band. This band would also easily make my Top 10 "Shut Up and Sing" list.
2) Neil Diamond - Has experienced a career resurgence thanks to stadium music programmers everywhere. I don't like one of his songs. Not one. Especially
1) Simon and Garfunkel - If I can go a couple years without hearing them, I really enjoy a listen to The Sound of Silence or The Boxer . But it's like an Orange Crush. You remember it tasting a hell of a lot better than it really tastes. And more than one in a half decade is too much. As for the remainder of their catalog, it is like fingernails across the chalkboard. I am a Rock , Cecilia , and My Little Town turn my stomach.
So there you have it music fans. These are very successful acts (some Hall of Fame acts), I'm a huge music fan, but yet there's a disconnect.
Maybe it's not them, it's me.
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