She was a lead actress in Hormones in 2008 and Bangkok Traffic Love Story in 2009.
Angelo traveled to Maldives taking a photoshoot for Honeymoon Travel magazine.
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In 2016 she starred her first movie titled One Day paired with Chantavit Dhanasevi Read the rest of this entry » Sushar Manaying or nickname "Aom". Sushar is daughter of Pornpan Wana popular folk singer.
Former MC in TV show "Strawberry Cheesecake" and step up to lead actress in Movie "Yes or No".
She has two names, Janie and Preem but Ae Supachai advised her to go with Preem as it's more different and unique.
Read the rest of this entry » Ungsumalynn Sirapatsakmetha (Thai: อังศุมาลิน สิรภัทรศักดิ์เมธา, RTGS: Angsumalin Siraphatsakmetha; born: July 13, 1991), or nickname Pattie (Thai: แพทตี้), is a Thai film and television actress and model.
It wasn't then that she realized how important Language is and so she pushed herself to learn in order to work in the entrainment field.
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Credit to: [email protected] Often said to be cute like Yaya and sweet like Vicki, Patricia Good is a young rising actress of Channel 3.
Growing up in Phuket, she studied in International studies all her life and barely knew how to speak Thai however, she was always passionate about acting since young.
On 1 January 1901, the six colonies federated, forming the Commonwealth of Australia.


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Project acronym altEJrepair
Project Characterisation of DNA Double-Strand Break Repair by Alternative End-Joining: Potential Targets for Cancer Therapy
Researcher (PI) Raphael CECCALDI
Host Institution (HI) INSTITUT CURIE
Call Details Starting Grant (StG), LS1, ERC-2016-STG
Summary DNA repair pathways evolved as an intricate network that senses DNA damage and resolves it in order to minimise genetic lesions and thus preventing tumour formation. Gaining in recognition the last few years, the alternative end-joining (alt-EJ) DNA repair pathway was recently shown to be up-regulated and required for cancer cell viability in the absence of homologous recombination-mediated repair (HR). Despite this integral role, the alt-EJ repair pathway remains poorly characterised in humans. As such, its molecular composition, regulation and crosstalk with HR and other repair pathways remain elusive. Additionally, the contribution of the alt-EJ pathway to tumour progression as well as the identification of a mutational signature associated with the use of alt-EJ has not yet been investigated. Moreover, the clinical relevance of developing small-molecule inhibitors targeting players in the alt-EJ pathway, such as the polymerase Pol Theta (Polθ), is of importance as current anticancer drug treatments have shown limited effectiveness in achieving cancer remission in patients with HR-deficient (HRD) tumours. Here, we propose a novel, multidisciplinary approach that aims to characterise the players and mechanisms of action involved in the utilisation of alt-EJ in cancer. This understanding will better elucidate the changing interplay between different DNA repair pathways, thus shedding light on whether and how the use of alt-EJ contributes to the pathogenic history and survival of HRD tumours, eventually paving the way for the development of novel anticancer therapeutics. For all the abovementioned reasons, we are convinced this project will have important implications in: 1) elucidating critical interconnections between DNA repair pathways, 2) improving the basic understanding of the composition, regulation and function of the alt-EJ pathway, and 3) facilitating the development of new synthetic lethality-based chemotherapeutics for the treatment of HRD tumours.
DNA repair pathways evolved as an intricate network that senses DNA damage and resolves it in order to minimise genetic lesions and thus preventing tumour formation. Gaining in recognition the last few years, the alternative end-joining (alt-EJ) DNA repair pathway was recently shown to be up-regulated and required for cancer cell viability in the absence of homologous recombination-mediated repair (HR). Despite this integral role, the alt-EJ repair pathway remains poorly characterised in humans. As such, its molecular composition, regulation and crosstalk with HR and other repair pathways remain elusive. Additionally, the contribution of the alt-EJ pathway to tumour progression as well as the identification of a mutational signature associated with the use of alt-EJ has not yet been investigated. Moreover, the clinical relevance of developing small-molecule inhibitors targeting players in the alt-EJ pathway, such as the polymerase Pol Theta (Polθ), is of importance as current anticancer drug treatments have shown limited effectiveness in achieving cancer remission in patients with HR-deficient (HRD) tumours. Here, we propose a novel, multidisciplinary approach that aims to characterise the players and mechanisms of action involved in the utilisation of alt-EJ in cancer. This understanding will better elucidate the changing interplay between different DNA repair pathways, thus shedding light on whether and how the use of alt-EJ contributes to the pathogenic history and survival of HRD tumours, eventually paving the way for the development of novel anticancer therapeutics. For all the abovementioned reasons, we are convinced this project will have important implications in: 1) elucidating critical interconnections between DNA repair pathways, 2) improving the basic understanding of the composition, regulation and function of the alt-EJ pathway, and 3) facilitating the development of new synthetic lethality-based chemotherapeutics for the treatment of HRD tumours.
Project acronym Autophagy in vitro
Project Reconstituting Autophagosome Biogenesis in vitro
Researcher (PI) Thomas Wollert
Host Institution (HI) INSTITUT PASTEUR
Summary Autophagy is a catabolic pathway that delivers cytoplasmic material to lysosomes for degradation. Under vegetative conditions, the pathway serves as quality control system, specifically targeting damaged or superfluous organelles and protein-aggregates. Cytotoxic stresses and starvation, however, induces the formation of larger autophagosomes that capture cargo unselectively. Autophagosomes are being generated from a cup-shaped precursor membrane, the isolation membrane, which expands to engulf cytoplasmic components. Sealing of this structure gives rise to the double-membrane surrounded autophagosomes. Two interconnected ubiquitin (Ub)-like conjugation systems coordinate the expansion of autophagosomes by conjugating the autophagy related (Atg)-protein Atg8 to the isolation membrane. In an effort to unravel the function of Atg8, we reconstituted the system on model membranes in vitro and found that Atg8 forms together with the Atg12–Atg5-Atg16 complex a membrane scaffold which is required for productive autophagy in yeast. Humans possess seven Atg8-homologs and two mutually exclusive Atg16-variants. Here, we propose to investigate the function of the human Ub-like conjugation system using a fully reconstituted in vitro system. The spatiotemporal organization of recombinant fluorescent-labeled proteins with synthetic model membranes will be investigated using confocal and TIRF-microscopy. Structural information will be obtained by atomic force and electron microscopy. Mechanistic insights, obtained from the in vitro work, will be tested in vivo in cultured human cells. We belief that revealing 1) the function of the human Ub-like conjugation system in autophagy, 2) the functional differences of Atg8-homologs and the two Atg16-variants Atg16L1 and TECPR1 and 3) how Atg16L1 coordinates non-canonical autophagy will provide essential insights into the pathophysiology of cancer, neurodegenerative, and autoimmune diseases.
Autophagy is a catabolic pathway that delivers cytoplasmic material to lysosomes for degradation. Under vegetative conditions, the pathway serves as quality control system, specifically targeting damaged or superfluous organelles and protein-aggregates. Cytotoxic stresses and starvation, however, induces the formation of larger autophagosomes that capture cargo unselectively. Autophagosomes are being generated from a cup-shaped precursor membrane, the isolation membrane, which expands to engulf cytoplasmic components. Sealing of this structure gives rise to the double-membrane surrounded autophagosomes. Two interconnected ubiquitin (Ub)-like conjugation systems coordinate the expansion of autophagosomes by conjugating the autophagy related (Atg)-protein Atg8 to the isolation membrane. In an effort to unravel the function of Atg8, we reconstituted the system on model membranes in vitro and found that Atg8 forms together with the Atg12–Atg5-Atg16 complex a membrane scaffold which is required for productive autophagy in yeast. Humans possess seven Atg8-homologs and two mutually exclusive Atg16-variants. Here, we propose to investigate the function of the human Ub-like conjugation system using a fully reconstituted in vitro system. The spatiotemporal organization of recombinant fluorescent-labeled proteins with synthetic model membranes will be investigated using confocal and TIRF-microscopy. Structural information will be obtained by atomic force and electron microscopy. Mechanistic insights, obtained from the in vitro work, will be tested in vivo in cultured human cells. We belief that revealing 1) the function of the human Ub-like conjugation system in autophagy, 2) the functional differences of Atg8-homologs and the two Atg16-variants Atg16L1 and TECPR1 and 3) how Atg16L1 coordinates non-canonical autophagy will provide essential insights into the pathophysiology of cancer, neurodegenerative, and autoimmune diseases.
Project acronym CD4DNASP
Project Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways
Researcher (PI) Lionel Jerome Apetoh
Host Institution (HI) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Summary This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation. Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors triggering TLR9-independent signaling. Activation of cytosolic DNA sensor-dependent signaling pathways has been clearly shown to trigger innate immune responses to microbial and host DNA, but the contribution of cytosolic DNA sensors to the differentiation of CD4 T cells, an essential event for shaping adaptive immune responses, has not been documented. This proposal aims to fill this current knowledge gap. We aim to decipher the molecular series of transcriptional events triggered by DNA in CD4 T cells that ultimately result in altered T cell differentiation. This aim will be addressed by combining in vitro and in vivo approaches such as advanced gene expression analysis of CD4 T cells and use of transgenic and gene-deficient mice. Structure activity relationship and biophysical studies will also be performed to unravel novel immunomodulators able to affect CD4 T cell differentiation.
This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation. Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors triggering TLR9-independent signaling. Activation of cytosolic DNA sensor-dependent signaling pathways has been clearly shown to trigger innate immune responses to microbial and host DNA, but the contribution of cytosolic DNA sensors to the differentiation of CD4 T cells, an essential event for shaping adaptive immune responses, has not been documented. This proposal aims to fill this current knowledge gap. We aim to decipher the molecular series of transcriptional events triggered by DNA in CD4 T cells that ultimately result in altered T cell differentiation. This aim will be addressed by combining in vitro and in vivo approaches such as advanced gene expression analysis of CD4 T cells and use of transgenic and gene-deficient mice. Structure activity relationship and biophysical studies will also be performed to unravel novel immunomodulators able to affect CD4 T cell differentiation.
Project acronym COLOUR PATTERN
Project Morphogenesis and Molecular Regulation of Colour Patterning in Birds
Researcher (PI) Marie Celine Manceau
Host Institution (HI) COLLEGE DE FRANCE
Summary Animals display a tremendous diversity of patterns ‒from the colourful designs that adorn their body to repeated segmented appendages. Natural patterns result from the formation of discrete domains within developing tissues through the integration of positional cues by cells that consequently adopt specific fates and produce spatial heterogeneity. How can such developmental processes underlie the apparent complexity and diversity of natural patterns? We propose to address this long-standing question with an innovative experimental design: we will make use of natural variation as a powerful tool to facilitate the identification of patterning molecules and morphogenetic events. We will study colour pattern, a crucial adaptive trait that varies extensively in nature, from large colour domains to periodic designs. In amniotes, colour pattern is formed by spatial differences in the distribution of pigment cells and integumentary appendages. While the pigmentation system has been well characterized, the mechanisms governing the formation of compartments in the skin of wild animals have remained unclear, largely because laboratory models do not display ecologically-relevant colour patterns. We will use a combination of forward genetics, developmental biology, modelling, and imaging to study natural variation in the large colour domains of Estrildid finches and the periodic stripes of Galliform birds. For both phenotypes, we will characterize the organization of the embryonic skin and the mode of patterning (i.e., instructional patterning via external cues vs locally-occurring self-organization) underlying their formation, and identify the molecular factors and developmental processes contributing to their variation. Results from these studies will elucidate the biochemical events and tissue rearrangements orchestrating colour patterning in development and shed light on how these processes shape natural variation in this trait‒ and more generally, in natural patterns.
Animals display a tremendous diversity of patterns ‒from the colourful designs that adorn their body to repeated segmented appendages. Natural patterns result from the formation of discrete domains within developing tissues through the integration of positional cues by cells that consequently adopt specific fates and produce spatial heterogeneity. How can such developmental processes underlie the apparent complexity and diversity of natural patterns? We propose to address this long-standing question with an innovative experimental design: we will make use of natural variation as a powerful tool to facilitate the identification of patterning molecules and morphogenetic events. We will study colour pattern, a crucial adaptive trait that varies extensively in nature, from large colour domains to periodic designs. In amniotes, colour pattern is formed by spatial differences in the distribution of pigment cells and integumentary appendages. While the pigmentation system has been well characterized, the mechanisms governing the formation of compartments in the skin of wild animals have remained unclear, largely because laboratory models do not display ecologically-relevant colour patterns. We will use a combination of forward genetics, developmental biology, modelling, and imaging to study natural variation in the large colour domains of Estrildid finches and the periodic stripes of Galliform birds. For both phenotypes, we will characterize the organization of the embryonic skin and the mode of patterning (i.e., instructional patterning via external cues vs locally-occurring self-organization) underlying their formation, and identify the molecular factors and developmental processes contributing to their variation. Results from these studies will elucidate the biochemical events and tissue rearrangements orchestrating colour patterning in development and shed light on how these processes shape natural variation in this trait‒ and more generally, in natural patterns.
Project acronym COMPUCELL
Project Autonomous Cellular Computers for Diagnosis
Researcher (PI) JEROME, Cédric Bonnet
Summary Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis. In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia. My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be reusable to diagnose other pathologies as well as for applications requiring custom-detection and bio-molecular computation like targeted therapy, drug delivery, or environmental monitoring.
Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis. In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia. My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be reusable to diagnose other pathologies as well as for applications requiring custom-detection and bio-molecular computation like targeted therapy, drug delivery, or environmental monitoring.
Project acronym CrIC
Project Molecular basis of the cross-talk between chronic inflammation and cancer
Researcher (PI) Nadine Laguette
Summary Cancer related inflammation (CRI) is a well-established hallmark of cancer. We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses. Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects of the immune system, resulting from increased pro-inflammatory cytokine levels and progressive bone marrow failure. Within this proposal, using SLX4-deficiency as a working model, I aim at investigating the molecular process underlying CRI. Based on our previous observation that the SLX4 complex binds to HIV-derived reverse-transcripts and promotes their degradation, my working hypothesis is that CRI results from the accumulation of endogenous pathological nucleic acids that are recognized by the innate immune system in the absence of SLX4. The present project should unveil the relationship between repression of pro-inflammatory cytokine production by proteins involved in DNA repair, DNA damage, and CRI, thereby opening unforeseen perspectives in the treatment of cancer patients.
Cancer related inflammation (CRI) is a well-established hallmark of cancer. We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses. Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects of the immune system, resulting from increased pro-inflammatory cytokine levels and progressive bone marrow failure. Within this proposal, using SLX4-deficiency as a working model, I aim at investigating the molecular process underlying CRI. Based on our previous observation that the SLX4 complex binds to HIV-derived reverse-transcripts and promotes their degradation, my working hypothesis is that CRI results from the accumulation of endogenous pathological nucleic acids that are recognized by the innate immune system in the absence of SLX4. The present project should unveil the relationship between repression of pro-inflammatory cytokine production by proteins involved in DNA repair, DNA damage, and CRI, thereby opening unforeseen perspectives in the treatment of cancer patients.
Project acronym ENVIROIMMUNE
Project Environmental modulators of the immune cell balance in health and disease
Researcher (PI) Markus Kleinewietfeld
Host Institution (HI) VIB
Summary The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T cells (Treg). However, little is known regarding environmental factors that influence the Th17/Treg balance. We recently discovered that a sodium-rich diet severely exacerbates experimental autoimmune encephalomyelitis (EAE) through an increased induction of pathogenic Th17 cells. Surprisingly, our preliminary data indicate that high-salt conditions also significantly impair Treg function, resembling a phenotype observed in several human autoimmune diseases. In addition, we have evidence that a high-salt diet affects the gut microbiota, implicating possible indirect effects on immune cells in vivo. Based on these findings we hypothesize that excess dietary salt represents an environmental risk factor for autoimmune diseases by modulating the Th17/Treg balance by several direct and indirect mechanisms. To address this hypothesis we will 1) examine the underlying mechanisms of high-salt induced Treg dysfunction and effects on the Treg/Th17 balance by molecular and functional analysis in vitro and compare it to known risk variants of human autoimmune diseases, and 2) define direct and indirect effects of excess dietary salt on the Th17/Treg balance and autoimmunity in vivo and explore potential novel pathways for targeted interventions. Thus, the proposed study will uncover the impact of a newly discovered environmental modulator of the immune cell balance and will ultimately pave the way for new approaches in therapy and prevention of autoimmune diseases.
The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T cells (Treg). However, little is known regarding environmental factors that influence the Th17/Treg balance. We recently discovered that a sodium-rich diet severely exacerbates experimental autoimmune encephalomyelitis (EAE) through an increased induction of pathogenic Th17 cells. Surprisingly, our preliminary data indicate that high-salt conditions also significantly impair Treg function, resembling a phenotype observed in several human autoimmune diseases. In addition, we have evidence that a high-salt diet affects the gut microbiota, implicating possible indirect effects on immune cells in vivo. Based on these findings we hypothesize that excess dietary salt represents an environmental risk factor for autoimmune diseases by modulating the Th17/Treg balance by several direct and indirect mechanisms. To address this hypothesis we will 1) examine the underlying mechanisms of high-salt induced Treg dysfunction and effects on the Treg/Th17 balance by molecular and functional analysis in vitro and compare it to known risk variants of human autoimmune diseases, and 2) define direct and indirect effects of excess dietary salt on the Th17/Treg balance and autoimmunity in vivo and explore potential novel pathways for targeted interventions. Thus, the proposed study will uncover the impact of a newly discovered environmental modulator of the immune cell balance and will ultimately pave the way for new approaches in therapy and prevention of autoimmune diseases.
Project acronym HRMEG
Project HRMEG: High-resolution magnetoencephalography: Towards non-invasive corticography
Researcher (PI) Lauri Tapio Parkkonen
Host Institution (HI) AALTO KORKEAKOULUSAATIO SR
Call Details
Summary To date, neuroimaging has provided a wealth of information on how the human brain works in health and disease. With functional magnetic resonance imaging (fMRI), we can obtain spatially precise information about long-lasting brain activations whereas electro- and magnetoencephalography (EEG/MEG) can track transient cortical responses at millisecond resolution. However, none of these methods excel in time-resolved detection of sustained cortical activations, which are typically reflected as bursts of gamma-range (30–150 Hz) oscillations, frequently present in invasive recordings in patients. Although we have recently demonstrated that in exceptional situations MEG can detect even single gamma responses, their signal-to-noise ratio is usually prohibitively low, largely due to the substantial distance (4–5 cm) between cortex and sensors. Here, I propose to exploit recent advances in a novel magnetic sensor technology—atomic magnetometry—to construct a new kind of MEG system that allows capturing cerebral magnetic fields within millimetres from the scalp. Our simulations show that this proximity leads up to a 5-fold increase in the signal amplitude and an order-of-magnitude improvement of spatial resolution compared to conventional MEG. Therefore, a high-resolution MEG (HRMEG) system based on atomic magnetometers should enable non-invasive recordings of cortical activity at unprecedented sensitivity and detail level, which I propose to capitalize on by characterizing cortical responses, particularly gamma oscillations, during complex cognitive tasks. Additionally, since atomic magnetometers can recover within milliseconds from fields of several tesla, I also propose to combine transcranial magnetic stimulation (TMS) with MEG, leveraging the reciprocity of TMS and MEG and thus allowing better-than-ever characterization of TMS-evoked responses. This proposal comprises the research towards a HRMEG system and its application to study the working human brain in a new way.
To date, neuroimaging has provided a wealth of information on how the human brain works in health and disease. With functional magnetic resonance imaging (fMRI), we can obtain spatially precise information about long-lasting brain activations whereas electro- and magnetoencephalography (EEG/MEG) can track transient cortical responses at millisecond resolution. However, none of these methods excel in time-resolved detection of sustained cortical activations, which are typically reflected as bursts of gamma-range (30–150 Hz) oscillations, frequently present in invasive recordings in patients. Although we have recently demonstrated that in exceptional situations MEG can detect even single gamma responses, their signal-to-noise ratio is usually prohibitively low, largely due to the substantial distance (4–5 cm) between cortex and sensors. Here, I propose to exploit recent advances in a novel magnetic sensor technology—atomic magnetometry—to construct a new kind of MEG system that allows capturing cerebral magnetic fields within millimetres from the scalp. Our simulations show that this proximity leads up to a 5-fold increase in the signal amplitude and an order-of-magnitude improvement of spatial resolution compared to conventional MEG. Therefore, a high-resolution MEG (HRMEG) system based on atomic magnetometers should enable non-invasive recordings of cortical activity at unprecedented sensitivity and detail level, which I propose to capitalize on by characterizing cortical responses, particularly gamma oscillations, during complex cognitive tasks. Additionally, since atomic magnetometers can recover within milliseconds from fields of several tesla, I also propose to combine transcranial magnetic stimulation (TMS) with MEG, leveraging the reciprocity of TMS and MEG and thus allowing better-than-ever characterization of TMS-evoked responses. This proposal comprises the research towards a HRMEG system and its application to study the working human brain in a new way.
Project acronym INTUMORX
Project Elucidation of intratumoral heterogeneity in Kras-driven cancers
Researcher (PI) Tuomas TAMMELA
Host Institution (HI) HELSINGIN YLIOPISTO
Summary The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ ("KP") mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.
The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ ("KP") mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.
Project acronym ISIFit
Project Individualised and self-adapting sound processing for cochlear implants
Researcher (PI) Tom Mark H. Francart
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Summary Cochlear implants (CIs) are successful auditory prostheses that enable people with deafness to hear through electrical stimulation of the auditory nerve. In a CI sound processor, a sound signal is converted into a sequence of electrical pulses. This conversion entails many parameters that should ideally be fine-tuned (fitted) for every individual patient, to account for various anatomical and physiological differences. In current clinical practice, devices are fitted during the initial rehabilitation and yearly thereafter. As fitting is very time consuming, only the bare minimum number of parameters is fitted individually. However, for many other parameters, for which currently the same default values are used for all patients, better speech understanding can be achieved with individual fitting. Apart from the fitting, CIs do not take into account the neural or perceptual effects of stimulation. The objective of this project is to provide better fitting to individual patients by developing a closed-loop CI that automatically adjusts its fitting and sound processing based on the neural response to speech. To achieve this, we will (1) objectively measure speech understanding, by recording the electroencephalogram (EEG) in response to ecological speech signals, (2) automatically fit a wide array of sound processing parameters accordingly using a genetic algorithm, and (3) develop a wearable closed-loop CI that continuously records the EEG and adjusts the fitting in real-life situations. This will lead to a better understanding of speech perception of people with a hearing impairment, an objective measure of speech intelligibility with many applications in diagnostics, a method to automatically fit CIs, and a novel closed-loop CI. For the patient this means improved speech intelligibility in noise and therefore better communication and quality of life. For the clinic this means improved efficiency and the ability to better fit devices.
Cochlear implants (CIs) are successful auditory prostheses that enable people with deafness to hear through electrical stimulation of the auditory nerve. In a CI sound processor, a sound signal is converted into a sequence of electrical pulses. This conversion entails many parameters that should ideally be fine-tuned (fitted) for every individual patient, to account for various anatomical and physiological differences. In current clinical practice, devices are fitted during the initial rehabilitation and yearly thereafter. As fitting is very time consuming, only the bare minimum number of parameters is fitted individually. However, for many other parameters, for which currently the same default values are used for all patients, better speech understanding can be achieved with individual fitting. Apart from the fitting, CIs do not take into account the neural or perceptual effects of stimulation. The objective of this project is to provide better fitting to individual patients by developing a closed-loop CI that automatically adjusts its fitting and sound processing based on the neural response to speech. To achieve this, we will (1) objectively measure speech understanding, by recording the electroencephalogram (EEG) in response to ecological speech signals, (2) automatically fit a wide array of sound processing parameters accordingly using a genetic algorithm, and (3) develop a wearable closed-loop CI that continuously records the EEG and adjusts the fitting in real-life situations. This will lead to a better understanding of speech perception of people with a hearing impairment, an objective measure of speech intelligibility with many applications in diagnostics, a method to automatically fit CIs, and a novel closed-loop CI. For the patient this means improved speech intelligibility in noise and therefore better communication and quality of life. For the clinic this means improved efficiency and the ability to better fit devices.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Angular 1.x Iframe with html content I do have html content comes from the API.
How do I display it with iframe ?
Something like
{ ..., template: "<h3 style="margin: 0px; padding: 0px; ..." ...}
Please provide demo if possible.
Thanks.

A: Create a pipe for iframe
import { Pipe, PipeTransform } from '@angular/core';
import { DomSanitizer} from '@angular/platform-browser';

@Pipe({ name: 'safe' })
export class SafePipe implements PipeTransform {
  constructor(private sanitizer: DomSanitizer) {}
  transform(url) {
    return this.sanitizer.bypassSecurityTrustResourceUrl(url);
  }
}

And in the component
@NgModule({
   declarations : [
     ...
     SafePipe
   ],
})

HTML

You can refer this Plunker
For Angular1.x Plunker

redpajama_set_name: RedPajamaStackExchange


text:
Director Bille August will head Cairo film festival jury
Cairo film fest president Mohamed Hefzy told Variety that he was honored to have gotten August to agree to serve as jury president for what he called the "historic 40th edition" of the event.
AGF srlREX Shutterstock
Danish director Bille August
Oscar-winning Danish director Bille August will preside over the jury of the Cairo Film Festival, which is being revamped by Egyptian producer Mohamed Hefzy. August is one of a very short list of film directors who can claim the rare distinction of winning two Cannes Palme d'Or awards.
August is most famous for directing "Pelle the Conqueror" which won the foreign-language Oscar, the Palme d'Or and a Golden Globe. He has also directed "The House of the Spirits," "Smilla's Sense Of Snow," and "Les Miserables." He is currently in pre-production for the upcoming Gianni Versace biopic called "The Emperor of Dreams."
August will be returning to Cairo after last participating in the event with "Les Miserables" in 1998.
According the report by Variety, Hefzy, who was appointed as president of the Cairo festival in March, praised August as "one of the eminent names in world cinema." Hefzy's production house Film Clinic has produced a number of acclaimed Egyptian titles well received in the international festival circuit such as Mohamed Diab's "Clash" and recent Cannes entry "Yomeddine".
Hefzy told Variety that he was honored to have gotten August to agree to serve as jury president for what he called the "historic 40th edition" of the event. He is the youngest president in the Cairo fest's history and the first chosen from within the country's film industry ranks.
Hefzy aims to raise the international profile of the Cairo fest - the oldest in the Arab and African region, which has lost some of its appeal in recent years due to Egypt's revolution and its aftermath. Hefzy told Variety that security fears have now subsided and tourism is picking up the country.
Since taking over as president he has reinstated the Cairo Film Connection co-production platform and give the fest a wider range of cinema from across the globe. Artistic director Youssef Cherif Rizkallah said more well-known international names will be added as jury members for the upcoming edition which will run Nov. 20-29.
EGYPTIAN CINEMA
MOHAMED HEFZY
FILM CLINIC
ARABIC CINEMA
ARTHOUSE CINEMA
Interview with Mohamed Hefzy
Cairo latest to offer Arab film prize
Arab Cinema Centre launches film & TV festival in Prague


text:
Enrique Fernández de Heredia y Gaztañaga va ser militar espanyol que va participar en la Guerra civil.

Biografia
Fernández d'Heredia era un militar de carrera. En 1932 va formar part de la missió militar que va ser enviada a Bolívia, i va romandre al país durant un any com a instructor de les Forces armades bolivianes. Al juliol de 1936, a l'esclat de la Guerra civil, era comandant d'artilleria a Madrid i es va mantenir fidel a la República.

Ascendit poc després a Tinent coronel, durant la contesa va ocupar el comandament de diverses unitats militars: la 3a Divisió o el XVIII Cos d'Exèrcit, el comandament de les quals va assumir després del final de la Batalla de Brunete. Al desembre de 1937 es trobava destinat en el Front de Terol al capdavant del XVIII Cos d'Exèrcit, preparat per a participar en una ofensiva contra la ciutat. El 24 de desembre va ser ascendit pel general Rojo al rang de coronel en reconeixement al seu èxit en envoltar la ciutat. A l'abril de 1938 va cedir el comandament del XVIII Cos d'Exèrcit a José del Barrio Navarro.

Obres
 —— (1935). Un año de misión en Bolivia. Librería internacional de Romo: Bolivia.

Referències

Militars republicans de la Guerra Civil espanyola

redpajama_set_name: RedPajamaWikipedia


Michael Hill Jewellers has got the go ahead to put their signs up in Launceston's central business district. The City of Launceston council unanimously approved the development application at its meeting on Thursday. The jewellers will be located on the corner of Charles and Brisbane Street. The application was specifically for the signs, and had nothing to do with the building's historical shop front. The councillors agreed the city had "dodged a bullet" regarding the historic shopfront which was planned to be replaced. The council received nearly 20 representations related to the works, raising concerns around the potential removal of the building's street-level facade and stained glass windows. The existing stained glass windows, tiles and framing are now to be kept and incorporated into the new design. Developers agreed to keep the shop front, which Councillor Janie Finlay said was a fantastic result for the community.
Michael Hill Jewellers has got the go ahead to put their signs up in Launceston's central business district.
The City of Launceston council unanimously approved the development application at its meeting on Thursday.
The jewellers will be located on the corner of Charles and Brisbane Street.
The application was specifically for the signs, and had nothing to do with the building's historical shop front.
The councillors agreed the city had "dodged a bullet" regarding the historic shopfront which was planned to be replaced.
The council received nearly 20 representations related to the works, raising concerns around the potential removal of the building's street-level facade and stained glass windows.
The existing stained glass windows, tiles and framing are now to be kept and incorporated into the new design.
Developers agreed to keep the shop front, which Councillor Janie Finlay said was a fantastic result for the community.


text:
Is a shortage of technical talent stifling the growth of UK businesses?
Discover how a skills shortage in the technology sector is preventing growth in the British economy and how businesses can overcome this issue
Published by Editorial team, last update Apr 6, 2019
Few business decision makers need convincing of the importance of IT in the digital workplace. However, anecdotal evidence suggests that unlike technology, skilled computer staff can be hard to come by. Moreover, the current IT skills shortage looks set to bite further. Here, we examine this unsettling trend.
Related: How to recruit IT professionals for your business
How big is the tech skills shortage?
According to data from Statista, the technical and IT skills gap became more pronounced in the following areas during 2018:
Big data and analytics development
Technical architecture
Security and resilience
In a survey of corporate leaders, nearly four out of five companies expected to increase the number of highly skilled positions over the coming years.
In contrast, only just over half of the respondents felt confident in their company's ability to find sufficient qualified staff for these crucial roles. Where job descriptions require a mix of creative and STEM (scientific, technical, engineering and maths) ability, candidates are most in demand. The elusive skills combination in this so-called overlap category includes numerous IT roles such as software designers, programmers and business analysts.
A snapshot of the IT skills crisis in the UK
A recent bulletin published by the London-based Edge Foundation documented the technical skills shortages in the UK economy. In data centres, for instance, as many as one in five key staff were of European (non-British) or foreign nationality. Worryingly for recruiters, the effects of Brexit look likely to aggravate the situation, at least in the short term. As Britain departs from the European Union, jobs vacancies will probably be less attractive to skilled workers from mainland Europe.
All in all, an approximate tally of 600,000 computing vacancies combined with the general lack of technical qualifications and experience could cost the UK up to £63 billion a year in lost productivity, experts calculate. In unveiling these alarming figures, techUK (the London-based association and collective voice of 900 leading and innovative companies, many of them SMEs) mentioned that all their survey respondents had reported experiencing a shortage of skilled staff.
How do you solve the skills shortage?
When pressed to identify the potential cause(s), some of the respondents in the above surveys blamed political failure and the educational system for not teaching enough pupils relevant GCSE subjects. Conversely, others singled out a lack of retraining, reskilling and upskilling of adults already in the workplace and who might have something to contribute.
The top temporary fixes to deal with the skills shortages included using contract workers to fill gaps, engaging recruitment agencies, advertising for staff through professional social networks such as LinkedIn and using internal referral programmes. Unfortunately, however, these tactics do little to address long-term needs.
Oliver Newton, the Edge Foundation's Director of Policy and Research and author of the above bulletin, cited an urgent need for technical and digital subjects to be at the core of the UK national curriculum. Mr Newton considered that education chiefs ought to address the inadequate and dwindling headcounts studying for IT and computing GCSEs as a matter of priority. Unfortunately, the numbers of pupils opting to study these subjects at GCSE level has been declining year on year since 2010.
Other suggestions included calls for governmental action via Ofsted (the Office for Standards Education, Children's Services and Skills), which might review school gradings. It could also use its influence to showcase prosperous, creative careers to young people.
Is IT nearshoring a solution to the shortage?
While addressing the root cause(s), developing a long-term strategy and implementing plans will continue to be vital, nearshoring taps into an available pool of qualified, skilled and experienced staff who are available right now. In other words, careful IT outsourcing delivers solutions today, by deploying expert team workers who can hit the ground running.
Nowadays, forward-thinking client organisations are making the most of this flexible, modern solution. These satisfied companies have seen how nearshoring provides competent, knowledgeable workers who make an early contribution and innovate IT within their industry.
Related: A simple guide to technology for non-tech entrepreneurs
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Vasileios is a Research Fellow at CEPS and an expert in various aspects of the circular economy. Prior to joining CEPS, Vasileios was a Project Officer at the Confederation of European Paper Industries where he worked, among others, on producer responsibility schemes for paper recycling in Europe. He has also worked as a trainee at the DG Environment of the European Commission where he dealt with the implementation of the Waste Framework Directive and the use of economic instruments for improving resource efficiency across the EU. Vasileios Rizos joined CEPS' Energy and Climate Change Unit in February 2013. His main research areas at CEPS include circular economy, industrial sustainability, green value chains, low-carbon transport and resource efficiency indicators. Vasileios has extensive experience in analysing the regulatory and market barriers and enablers to the adoption of circular economy strategies by EU businesses. Vasileios holds an MSc in Ecological Economics from the University of Edinburgh and a 5-year degree in Agricultural Economics and Rural Development from the Agricultural University of Athens. He is fluent in English and Greek.
Eleanor is currently a Researcher in the Energy and Climate Change Unit at CEPS, she has over three years of experience working in the low-carbon energy field. Her research focuses on the circular economy as well as the challenges associated with the transition to low-carbon energy. She has worked on topics such as the role of business in the circular economy, energy prices for energy intensive industries, Guarantees of Origin and on the design of the electricity market. Previous to her work at CEPS, Eleanor worked as an engineering consultant, advising investors and developers on commercial renewable energy projects. This work involved evaluating several aspects of the development process for renewable energy projects from a technical point of view as well as writing research papers for clients. Eleanor holds a MSc. in Energy Policy for Sustainability in the Science Policy Research Unit (SPRU) at the University of Sussex. She also holds a BSc. in Mathematics with Economics from the University of Sussex.


As healthy-haired naturals, there are various things we have to stay on top of: moisture levels, minimizing breakage, protective styling and healthy ends, just to name a few.
While most of these regimens and techniques cater to our new growth, it's important to take note of the state of our hair health, overall, to avoid continuing any detrimental habits. One of the biggest concerns we face would have to be the thinning of our fragile edges. Unfortunately, there's no over-the-counter cream or regimen that will repair damage that has already been done. The most we can do is avoid common pitfalls, such as styles that are too tight and stressful on the edges, products loaded with breakage-inducing alcohols and too much heat styling.
Once we've gotten those habits out of the way, the next thing to reflect on is diet, of course! A well-balanced meal full of fibers, nutrients and proteins will ensure hair follicles are properly stimulated and vibrant. Don't forget to fit in some exercising to improve the scalp's circulation, as well! Also, make sure to check with your doctor in case your hair thinning is due to an underlying illness. Here are three all-natural remedies for thinning edges. Remember, they won't serve as a quick fix! They will, however, stimulate hair growth and help you take better care of it as it comes in.
JBCO is the unrefined version of Castor Oil. This means the full health benefits and nutrients were not lost during processing. A daily or weekly (depending on the severity) deep temple massage will greatly improve circulation and stimulation of the hair follicle. JBCO is scientifically proven to remove toxins and impurities from the scalp. This will allow your natural oils to function properly, creating a healthy environment and nourishment for new growth.
Similarly to Jamaican Black Castor Oil, Peppermint Essential Oil is an antibacterial, known for removing impurities causing growth obstructions. Its cooling effect also relaxes the follicle, promoting healthy hair growth. Since Jojoba is the oil closest to that of our own natural oils, it is the best choice for a carrier oil. A soothing carrier oil is needed with Peppermint Oil because of how potent it can be. I usually add equal parts. Another great all-natural and effective mixture is Basil Oil and Jojoba. Consistent and weekly pre-poo (before cleansing) scalp massages with either mixture will improve hair growth with major results within the first three months.
Aloe Vera contains more than 20 vitamins and minerals essential for hair growth. It's almost rare to find a product without it as an ingredient. The anti-bacterial properties of Aloe help you maintain a build-up-free scalp. While unclogging, it also balances and restores the pH, aiding in hair growth, shine and overall health. If you suffer from Alopecia, aloe is commonly suggested as the best natural remedy in preventing further hair loss. Using it as a sealant over your moisturizers and leave-ins or simply including it in your regimen overall will greatly improve your hair's growth cycle. Focus on your edges (apply more) during application.
This post is sponsored by Carol's Daughter.


In case you didn't guess from the title, Sea Battle is a port of the Intellivision game of the same name. Sea Battle never saw release during the 2600's heyday, but Intellivision Productions produced a limited number of professionally produced carts in 2000. These carts sold out quickly and due to copyright restrictions the rom file has not released, making it still widely unavailable to most gamers.
Sea Battle is a naval combat game in which two players must attempt to wipe out each others armada through a series of strategic battles. While it was a smash hit on the Intellivision, it's success on the 2600 would have been questionable. The Intellivision version made use of all the keys on the keypad, but since the 2600 lacked a keypad the game had to be simplified. Certain features such as laying mines had to be cut out, taking away some of the challenge. Also simplified were the graphics since the 2600's display abilities were well below that of the Intellivision. This left the game looking very blocky, and rather ugly. The final nail in Sea Battle's coffin was the lack of a one player mode, Mattel didn't want any more two player only games (see Sword Fight).
Even though the 2600 version of Sea Battle was watered down (no pun intended), it's still fun to play. The 2600 library is fairly void of serious two player strategy games, and Sea Battle would have made a nice addition. But without a single player option and blocky graphics, Sea Battle may not have had wide enough appeal to sell sufficiently.
A screenshot mockup exists which shows the player's bases on the left and right side of the screen instead of the top and bottom. It's unknown if any version of the game was developed which featured the side bases.


text:
Do Masks Make a Difference in Customer Perception of Service Quality in Hotels and Restaurants?
Home/Do Masks Make a Difference in Customer Perception of Service Quality in Hotels and Restaurants?
By Isabel Crowther|2020-12-16T15:43:41-05:00December 16th, 2020|
Dr. Cihan Cobanoglu | December 16, 2020
By Dr. Cihan Cobanoglu
As COVID-19 spreads person to person through respiratory droplets, U.S. Center for Disease Control and Prevention recommends that everyone wears a mask when they are around other people (CDC, 2020). As such, many companies have enforced mask wearing policy for their customers and employees (Markowitz, 2020). As a result, many people have started to use masks in the United States. It is noteworthy that while it is new to American culture, mask wearing is common in some Asian cultures (Beglin, 2020).
Figure 1: Type of service person and mask types used in the study
In terms of academic research, the current body of literature lacks an investigation on how wearing a mask by hotel and restaurant employees can impact guests' perceptions, emotions and behavior. Using a sample of 1,800 Americans, the University of South Florida's M3 Center for Hospitality Technology and Innovation conducted an experimental research study to better understand this customer perceptions and behavior related to mask wearing in a hotel or restaurant.
In this study, respondents visited a restaurant or hotel as a guest, doing so virtually. Each respondent was shown a random picture of a service employee with or without a mask. The pictures of the servers were obtained from thispersondoesnotexist.com, a website that uses artificial intelligence to generate realistic images of human faces. USF researchers included photos of men and women across three races (Black, white and Asian) in the photo pool. Each picture was manipulated to show the employee wearing a mask in one five color schemes: white, black, blue, colorful, clear. A control group was also included with servers wearing no mask.
After showing respondents to the randomly chosen picture, respondents were asked about their impressions of the server and subsequent perceptions, emotions and behavior. First impression theory states that most people form their opinions about a person within a few seconds after they see them (Hognas, 2015; Shao, 2017). Even though people know that first impressions should not be enough to make a judgment about another person, most people do it anyway (Ludden, 2017).
A total of 1,812 Americans responded to the survey, of which 913 received the hotel scenario; 899 received the restaurant scenario. As shown in Figure 2, all the variables were rated higher with the exception of physical attractiveness. On a 7-point scale, suitability of the server (with mask) was rated as 5.06. Suitability was rated 4.79 for servers wearing no masks. Similarly, gratitude was rated as 5.32 for servers with mask and 4.52 for server with no mask; service quality was rated 5.55 for server with mask, and 4.59 for server with no mask; trust was rated as 5.57 for server wearing masks and 4.71 for servers without masks; reciprocal behaviors was rated as 4.91 for servers wearing masks and 3.85 for servers without masks. Interestingly, respondents' anxiety levels were significantly reduced when the viewed servers wearing masks.
The only variable with non-significant difference was physical attraction. It was rated 5.55 for servers with a mask and 5.43 for servers without a mask. Results show that customers perceive higher service quality in a restaurant or hotel if employees wear masks, regardless of the color or type of mask. Results also show that wearing a mask does not make the service person less attractive or more attractive. No significant differences were found between how male and female respondents perceived the masks.
Figure 2: Variable Ratings
What color mask is better?
USF researchers also analyzed the data to understand if there is any difference in respondents' perceptions based on the different types/colors of mask used by servers. Results show for all the categories, a white mask is perceived the highest, followed by a colorful mask, black mask, blue mask and clear mask (See Figure 3). A possible explanation for this might be the usual association of white as the color of cleanliness and sanitation. Based on the results of this study, scholars recommend hotel and restaurant employees use a white mask
Figure 3: Mean values for the different masks
The University of South Florida's M3 Center study with 1,800 Americans showed that hotels and restaurants should enforce mask wearing policy for service employees. The results showed that guests perceive higher service quality, show trust, gratitude, and reciprocal behaviors in establishments where servers wear masks. Interestingly, guests get anxious when they see a service person without a mask. Wearing a mask (or opting against one) made no difference on guests' perceived attractiveness of the servers.
Results also showed a white mask is perceived the highest, followed by a colorful mask and a black mask. Clear masks were perceived the lowest of all mask types. Researchers recommend that hotels and restaurants opt for white masks, if possible. While many service establishments use clear masks as they believe they show the expressions of the service person, this study shows that customers are not likely to make that same connection and the masks were perceived as significantly less valuable than others.
Authors: Cihan Cobanoglu, Faizan Ali, Luana Nanu, Khuraman Shahtakhtinskaya, Imran Rahman
About Dr. Cihan Cobanoglu
Dr. Cihan Cobanoglu is the McKibbon Endowed Chair Professor of the School of Hospitality and Tourism Management (SHRM) in the Muma College of Business at the University of South Florida (USF), who also serves as the Director of the M3 Center for Hospitality Technology and Innovation and Coordinator of International Programs for the School of Hospitality and Tourism Management.
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PhpED Settings Manager updated to include Code Snippets and updater!
A new version of PhpED Settings Manager is available. Code Snippets are now included in import / export. Also added is a 'check for updates' feature with built-in asynchronous downloader!
clue-by-4.org has finally received a nice facelift, bringing along a more modern design. This version also includes a discussion forum for posting bug reports, queries or general comments about the software available.
I hope you also favour it over the previous incarnation!
LFS Replay Manager update released!
Not having had any updates for the past 18 months, and development somewhat considered dropped, I've decided to make some much needed updates and changes and release a new version.


Simply Rins grabbed the Best Beauty and Fashion Blog, Luzon Level, in the recently concluded 2011 Philippine Blog Awards (PBA). And we were a finalist in the same category for the national level. The awards night was held last December 03, 2011 at the Carlos P. Romulo Theater, RCBC Plaza in Makati City.
The Philippine Blog Awards happens every year since 2007 and its goal is to give recognition to outstanding blogs here in the country. Being a finalist already made me ecstatic. Winning was definitely an icing on the cake.
It has been a little over a year since I transformed Simply Rins into a nail art blog. I've had my shares of ups and downs. The worst that I have experienced is meeting or encountering people that reacts with an odd expression when I tell them that I blog about nail art. They simply don't get it. This is NOT just a nail art blog.
Simply Rins is not just a gallery of nail art designs. It has become an opportunity for me to reach out to all those who share the same passion. It continuously challenges me to develop my skills and creativity so I or my nail designs can serve as inspiration to others. But most importantly, this blog encourages self expression, regardless of form.
This is me, accepting the award.
If I am not mistaken, this is the first time a dedicated nail art blog has been recognized by the PBA. I am hopeful that this recognition can somehow change how some people think that nail blogs do not really amount to anything. I also hope that this will serve as an inspiration to all nail or nail art bloggers out there to continue painting their nails because we put more than nail polish or nail art on the table.
The trophy and my Snowman Parade nail art design.
I apologize for my serious sentiments. This really means a lot to me and I want to believe, to the nail art community. And so I SHARE this recognition to all nail/nail art bloggers. Particularly to fellow Filipina nail art blogger -- Trixie of Nailfiled, who was also a finalist under Best Beauty and Fashion Blog in the national level.
I thought that the award would be the highest point of the evening. There was something greater. A few minutes after we got out of the theater, a few girls introduced themselves as my readers. I was totally overwhelmed and was practically speechless. I never imagined how wonderful it is to meet followers of my blog. They even asked if they could take a photo with me. I sort of felt like a celebrity. Really. If you girls are reading this, thank you. You made my evening perfect.
With my very supportive parents.
So many opportunities knocked this year for Simply Rins and I know that none of them is possible without my family, my friends, and my readers. From the bottom of my heart, I thank you for your support. Thank you for all the messages that you sent me, for all the comments and suggestions. And of course, thank you to the Philippine Blog Awards for the recognition you have given my blog this year.
Special thanks goes out to 2 of my very good friends, Fitz of Ready To Be Rich and Don of Bongga Ba. Their support, generosity, and encouragement is overflowing. Fitz won 2011 Best Business Blog (National) for the second time and Don grabbed 2011 Best Lifestyle Blog (Luzon).
Me, Fitz, and Don during the PBA 2011.
I also had the chance to catch up with a friend way back in high school, Mitzi. She won 2011 Best Food and Beverage Blog (Luzon). You can check out her awesome food blog here. It was so nice to see you after a very long time.
My sincere congratulations to all the winners of the 2011 Philippine Blog Awards!
Video courtesy of my mom.
or subscribe to Simply Rins via reader.
Congratulations! it's just about 3 months ago when I started reading and following your blog. and i can say that you are not just an inspiration but a hope to me. A hope that one day, nail enthusiasts, like me, will also be recognized not just here but even outside Philippines. I can only imagine your happiness right now. Again,congratulations and I do hope you will keep on inspiring girls and bloggers just like me. Kudos!
Your blog is amazing, you are so talented and deserved the prize.
Way To Go Rins!! I am a follower from North Florida who is truly inspired by your art and passion. Thank you so very much!!
Hiii Ms Rina! This is Cat (or Denise, however you want to call me) haha, the niece of Don Triviño. :) Congratulations again! Checking out your site now, and you undoubtedly deserved the win. See you again soon!
BONGGA!!!!!! BONGGA KA NA DIN!!!
Rina..heartiest congratulations to u!!!!!! I am extremely happy for you!! U totally deserve this and much more! (hugs)!!!
U deserve this and much more *-* kisses!
Congrats! That's awesome! You definitely deserve it-love your nail art and your b log!
Oh WOW! Congratulations Rins! I just love your blog and you are right, we are sharing more than nail art here. The support and creativity that is shown on nail blogs is really wonderful. Congratulations for your achievement!
I really hope this is a start for nail art blogs to be recognized as more than just parading nail designs.
Just saw this and I'm amazed! Congrats! (^_^) I think you deserved it.


text:
package com.instagram;

import com.instagram.common.json.annotation.JsonField;
import com.instagram.common.json.annotation.JsonType;

@JsonType
class Dessert {
  @JsonField(fieldName="type")
  String type;

  @JsonField(fieldName="rating")
  float rating;
}

redpajama_set_name: RedPajamaGithub


text:
MSU coach sees similarities between Dak Prescott and Auburn QB Sean White
Matthew Stevens
AUBURN — Mississippi State head coach Dan Mullen trusts what he sees from Auburn's quarterback with his own eyes and not what he's handed right now on a stat sheet.
When addressing the play Sean White, the current Southeastern Conference's leader in passing completion rate, Mullen said Monday he saw similarities to arguably the most successful player in MSU's and Mullen's coaching history – Dak Prescott.
"He is going to go get you some tough gritty yards when he needs to and can extend plays and make things happen with his legs when he needs to," Mullen said Monday in his weekly media conference.
Through the first month of the season, White has been categorized as the traditional passer and East Mississippi Community College transfer John Franklin III has been making more news with his legs but the Bulldogs head coach thinks his defense needs to be prepared for White to change the pocket on certain plays.
As Franklin broke stride immediately on a 80-yard touchdown run in a 58-7 victory over an overmatched Louisiana-Monroe, White knew that was speed he didn't have but was glad to have that element as a teammate if the situation calls for it. Following his 239-yard, two-touchdown performance Saturday, White tried to convince media that his athletic ability isn't something to ignore at all.
"I can run a little bit," White said with a smile. "You know, obviously not as fast as John is, I mean that (touchdown run) was pretty sick. But, I mean, I can run a little bit when it's needed and open it up for our running backs."
During White's first five starts of the 2016 season, the sophomore has four runs for over 10 yards and most of them have been designed play calls when the middle of the field is wide open. Auburn coaches have been steadfast in their opinion that White can make a difference with his feet if the defense is going to refuse to use a spy to monitor a possible scramble.
"I thought he ran the offense very well (against Louisiana-Monroe) and played with a lot of good decisions in tempo," Auburn offensive coordinator Rhett Lashlee said about White on Sunday. "A lot of times when we run the ball there are pass options and I thought he made a lot of good decisions."
Mullen was clearly on the field for White's first ever college game as he made his debut last year at Jordan-Hare Stadium in a 17-9 loss to Mississippi State. The loss for Auburn was the first game under Auburn head coach Gus Malzahn that the Tigers failed to score a touchdown.
After a failed three-week stretch from Jeremy Johnson, Auburn attempted to match White, a former Elite 11 camp most valuable player out of high school, with the first-team All-Southeastern Conference quarterback Dak Prescott. While the odds weren't in White's favor to succeed, the result in the win/loss column is all he remembers.
"Obviously it was his first start and I thought he handled himself well last year, but we obviously didn't get the win," Lashlee said. "That's something he remembers. A year later he's been on the road and won before on the road."
Just two weeks ago, Auburn again failed to find the end zone but the difference was simple: Auburn defeated LSU 18-13 thanks to six field goals by Daniel Carlson. In that win over LSU, White tossed no interceptions and Auburn (3-2, 1-1 in SEC) won the turnover battle.
"I would hope it's night and day," Lashlee said on White's difference from his first start last season. "I think you can see he's comfortable. I felt like he played hard last year and he wasn't scared of anything but naturally it was all brand new. He was a little bit of deer in the headlights."
MSU's coach certainly isn't preparing for a naïve and possibly vulnerable element at the quarterback position in this critical weekend matchup for both programs.
"It looks like they have settled on Sean White and I think that gives him some confidence out there on the field," Mullen said. "They are going to do things around what he does well and you have seen him play well when they do that."


What is a Performance Bond in Michigan?
How much does a Surety Performance Bond in Michigan?
The expense of a performance and payment bond can differ widely depending on the amount of coverage that is needed. It is based upon the overall quantity of the contract. Things that can affect this prices are the viewed threat of the task, the monetary position of the entity being bonded, plus other aspects.
Bond prices vary based upon the job size. The cost of a bond is approximated through a number of back-of-the-envelope computations. In basic, the expense is approximately 3 percent (3%) for jobs under $800,000 and after that the percentage is lower as the agreement amount increases. We work vigilantly to discover the most affordable premiums possible in the state of Michigan Please call us today at (904) 587-4872. We'll find you the extremely finest rate possible for your upkeep bond or conclusion bond.
These rates are for Merit clients, Standard rates are higher.
What is the process to get a Performance and Payment Bond in Michigan?
We make it simple to get an agreement efficiency bond. Just click here to get our Michigan Performance Application. Fill it out and after that email it and the Michigan agreement documents to [email protected] or fax to 855-433-4192.
You can likewise call us at (904) 587-4872. We completely review each and every application for business bonds and then send it to the surety that we think will supply the very best p & p bond for your matter. The surety broker will carry out a credit check. We have a high success rate in getting our clients performance and payment bonds at the very best rates possible.
What is a Payment Bond? Is it included with the Performance Bond?
A payment bond is a bond that ensures that the subcontractors and material suppliers are paid. The payment supplies that if the subcontractors are not paid timely and they make a legitimate claim, then the surety will pay them (and then gather and try from the basic contractor). And yes, it's included with the Performance Bond.
What is a payment and surety performance bond? What is an agreement bond?
Typically, a payment and surety performance bond are done together in the very same contract by the surety. In this manner, the owner of the project is guaranteed that the task can be completed pursuant to the regards to the contract which it will not be liened by any contractor. The bond is performance security for the advantage of the owner.
The main company is the entity that gets the bond. It is for the advantage of the owner (or in the case of government agreement work, the governmental entity). It's the general professional that needs to get the bond and be underwritten before the performance and maintenance and payment bond is written by the surety. This is likewise referred to as bonding a service.
Just call us. We'll work with you to get the finest Michigan bond possible.
See our Minnesota Performance Bond Application here.
Performance Bonds can be quite complicated to understand, specifically if you don't understand how it actually works. Most folks think of this as a type of insurance, but it's only a kind of guarantee that the principal will do their work correctly. Insurance businesses can provide a Surety Performance Bond, but this is not insurance because its function is very different. Most folks would anticipate you to get a Surety Performance Bond before they consider your services because it is a form of guarantee to them.
If you would like to get a license bond, permit bond, commercial bond and more, you have to know how they really work. We are going to provide some good info on the importance of Performance Bonds and how they work.
Performance Bonds will usually be required by the public as it will protect them and it will guarantee that the principal will fulfill their obligations. As the principal, you need to get a license Surety Performance Bond to guarantee that your company will abide by the laws and you need a contract bond to make sure that a public construction project will be accomplished. There are examples that will offer an idea on Surety Performance Bond.
This is actually made for the clients since they will be protected by the bond, but it can provide benefits to you as well as they would trust you if you have this.
Performance Bonds are actually considered as a three-party agreement among a surety company, the principal and the obliged. The principal is the employer or company that will do the work while the obliged is the project owner.
Construction companies will invariably be required by the law to purchase Performance Bonds if they are going for a public project. Once the government demands a construction company to do something, the winning contractor should obtain a host of bonds.
The bond will guarantee that the sub-contractors and other workers will likely be paid even if the contractor defaults. The contractor will likely be accountable in covering any losses, but as soon as they already reached their limit, the duty will fall to the surety company.
Performance Bonds are generally offered by insurance businesses, but you can look for some separate surety companies that specialize in these unique products. A surety company must be licensed by a state Department of Insurance.
Applying for a bond isn't as easy as you think as the candidates will encounter a procedure comparable to a loan approval. The bond underwriters will review the financial history of a candidate, credit profile, managerial team and other important aspects.
It would mean that there is a chance that you won't be accepted for a Surety Performance Bond, especially if the bond underwriters saw something negative.
There's no specific cost for a Surety Performance Bond as it will depend upon several reasons like the bond type, bond amount, where the bond will be issued, contractual risk, the credit history of the applicant and many more.
There are plenty of bonds available right now and the cost will usually depend upon the type of bond that you'll get. The amount of bond that you will is also an issue because you could get a $10,000 bond or a $25,000 bond.
In case you have a credit score of above or near 700, you will certainly be eligible for the standard bonding market and you just need to pay a premium that is 1 to 4 percent of the Surety Performance Bond amount. If you are going to actually get a $10,000 bond, it will really cost around $100 to $400.
There's a possibility that your license and permit bond would be denied by the insurance organizations and it will always depend upon the background check that they did. If they think that it will be a big risk to give you a Surety Performance Bond, they will surely deny your application. Credit rating will be a deciding factor as well because if you will have a bad credit history, it will probably be difficult to get a Surety Performance Bond because businesses will think of you as a risk. If your credit rating is bad, you may still be approved, but you need to pay an interest rate of 10 to 20 percent.
If you really want to get your Surety Performance Bond, you will need to make sure that you will understand the process so you won't make a mistake. It won't be simple to apply, but if your requirements are complete and you are eligible, you could obtain a Surety Performance Bond.


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Community Field Study Internship with UC Irvine – Allison D.
Addiction Information
New Directions for Women proudly celebrates another opportunity to share the results of partnership and research. Another UC Irvine student has taken advantage of the opportunity to perform field education at New Directions for Women. For participating students, we provide a real-life agency setting where students of various disciplines can come to study, observe and practice their skills while broadening our community presence. The paper presented here is a testament to how a student can be exposed to the problems that women with addiction face and also educate the student on how New Directions for Women treats women, pregnant women and women with children. Read and enjoy.
Field Study Project
"My field study project reflects upon my time spent at New Directions for Women, a rehabilitation center for women with drug and alcohol addictions in Costa Mesa, California. I shadowed and interacted with a group of about eight patients, ranging from ages 20 through 55, during their clinical trials, meetings, outings and intervention programs. The last four years as an undergraduate in the school of social ecology and in the criminology, law and society department has helped me integrate much of my studies to my field site. Through classes such as "Legal Sanctions", "Prison, Punishment and Corrections", "Race, Ethnicity and Social Control", and "Crime and Public Policy", I have incorporated my academic learning and lessons into a tangible and direct life study.
Not only was I able to relate my academic studies to my internship site, but I was also able to learn valuable life lessons as well as develop a deeper understanding of life and provided meaning service to the public and community. In a sense, the patients at the rehabilitation center taught and guided me through life's complicated mazes through their personal stories. During the past 8 weeks, I have learned and grew a lot as a person due to the life lessons the patients reflected on and their personal struggles and problems. One of the main things I learned during my stay at the rehabilitation center is understanding, compassion and fearlessness. I became aware of the problems people in society faced that I was never exposed to, such as addiction, poverty, violence, the lack of family and moral support. Through these women's support system for each other and the rehab's staff want and passion to help these patients, compassion was easy to find in every corner of the rehab center. The patients exposed themselves physically and emotionally to life's harsh reality, many of who questioned why they are still alive and breathing today. The ability for them to wake up every morning and face what life has to offer after their addictive and obsessive past describes them as having an un-daunting and fearless nature, something I seldomly posses.
I integrated my academic training and knowledge from school through my field placement site. The last year and a half of my studies under the Criminology, Law and Society department has taught me much about legal policies, governmental organizations, the effects of gaps between governmental institutions (such as courts) and institutionalized programs (such as rehab centers), the lack of funding in programs, conflict theory, racial and gender conflicts and setbacks within the institutions, and the role of women in society. I noticed that these lessons and problems were reflected upon and brought up through my field site.
During my studies with Professor Turner in her class, "Prison, Punishment and Corrections," she noted that aside from the rehab program, patients also need other factors to help them succeed recovery and in overcoming relapses. Family support, moral support, a goal and a want to live sober, and moving away from triggers are the best cures to become sober.
"Triggers" is a term used at the rehab center and it means anything that would bring back or remind patients of the addictive substances. For example, the thought of bars or their drug dealers are trigger because they are accessible and can make the patient relapse if they are not strong enough. During my field study, a handful of patients were released because their time at the site expired due to money and insurance, or the court order specified a certain amount of time they were able to stay. I contemplated on the effect of these patients returning home back to the place, area, friends and people that made them become addicts in the first place and realized that they are going to be "triggered" as soon as they return back to the place it all started. By returning back to the root of the problem, these patients are entering (what Professor Turner lectured as) into a "viscous cycle" because they will keep churning in and out of the system unless they relieve themselves of the same friends and area.
The lack of funding is another substantial dilemma. This is the only gender-specific rehab center in Orange County that is accredited by CARF, Commission of Accreditation of Rehabilitation Facilities, and it only houses 30 people. There is a waitlist of patients waiting to be admitted into the site because of their accreditation and they cannot admit more than thirty. This nonprofit rehab center is funded by programs, fundraisers, and a thrifty boutique shop in Newport Beach that sells used items to support the facility. Lack of government funding in California and the country means fewer programs, fewer beds, fewer services and staff, all of which are highly needed to treat people and keep them out of prisons and jails. I learned in Professor Wakefield's class, Legal Sanctions, that the more people being sent to jails and prisons, the more people being churned in and out of the system with no end to the vicious cycle. Intervention programs such as rehab centers work well, but generally the state's funding in California are being put into building more prisons instead of programs to help people deal with their behavior and attitudes. Therefore, today there is less money provided for school, governmental programs and assistance and housing. Rehab and intervention programs and institutions are cheaper, and in the long run, less expensive than shoving people in prisons and jails.
When people asked me where am I doing my field study, I told them that I am volunteering at a women's rehab center with patients ranging from 18 to 55. Many people asked if there were such a thing as a women's rehab center because they thought that only young celebrity women or really impoverished women were prone to addiction. I replied that women of all backgrounds are just as likely to succumb to addiction. I believe that people are more surprised when they find out that the women in today's society can be admitted to a rehab center, especially the older women. The image and role of women in today's society has changed somewhat because a lot of people seem to believe that women are those who "hold down the fort," and who are the homemakers, usually depicted as raising children and the caregiver, therefore realizing that women can also go to rehab shocks some of the older people I spoke with. In reality, women have changed a lot in the past few decades such as working, becoming independent, divorcing their husbands and becoming a single parent, and there are even female politicians and female in higher governmental offices and running corporations.
I chose to intern at a women's rehab center because I wanted to learn and understand why people have addictive behaviors and how people become dependent on substances. I wanted to figure out whether or not it was nature or nurture that make people succumb to illegal narcotics and alcohol and if people are able to change. My goal was to understand why people turn to alcohol and drugs as a pastime or as a support system. Through providing service to the rehab center, I learned a new level of knowledge about people and myself. I learned the different backgrounds people come from, how they are able to change in a positive way, how they are fighting a battle with a chronic disease, and I became a better citizen through the act of service, reciprocity and meeting these patients.
By volunteering at the rehab center, I am helping these women cope with their addiction and to make them realize that they do not need to resort to drugs or alcohol. Yet at the same time, through interacting and opening up, they have taught me to understand that people with addictive behavior or not "bad", they are normal people with different issues that I have never been exposed to, and experiencing a disease. It made me realize how fortunate I am to overcome peer pressure, to have a loving family and a grounded, strong support system. After a few days of coming home from the rehabilitation center and as I walk into my home and see my family, I am thankful and grateful to live my life without violence, abuse, or neglect.
I have learned and grew a lot as a person due to the life lessons and stories the patients spoke of. Before interning, I never understood why people would want to resort to drugs and alcohol as an escape from their life's trouble. I never had an addictive personality or behavior even through my teenage and trial phases. I never wanted to try drugs because I've seen the effects of drugs on the brain and people's dependence on it, however I never understood why people would still try drugs even though they know it is bad for their body and their lives. After working and speaking with the patients, I started understanding that other people have different measures and ways to cope with their troubles. Some people have no control over certain situations and by doing drugs or drinking, they feel that they can control the amount and control what they put into their bodies. There is nothing dramatically different about these patients, they are not mentally insane or physically different, they just have a coping problem with their addictions but they are just as sane as anyone in my family. It made me realize that these patients are not atypical, they are people like me but with different life problems thus I should not discriminate or look down upon them. During a clinical meeting, I learned that becoming addictive to drugs is a disease of the brain. Just like liver disease, by consuming too much alcohol, it will start to deteriorate your liver, drugs and brain are the same thing. I never knew that the brain could deteriorate because of drugs and I always thought that becoming a drug addict was not because of your brain but because of your own personal choices. I then started to look at addiction and people with drug addiction in a different way, it is not necessarily their fault, it is also their body functioning in ways that they cannot control.
There were times I felt vulnerable and faced challenges and difficult obstacles during my field study. I am normally an anti-social person; I like to be around my small, close group of friends that I am comfortable with. I takes me a while to open to people and it is normally very difficult for me to make new friends. I usually clam up in around new people and especially large groups. However, after my experience in the rehab center, it was I who had to open up conversations first, I had to make other people want to talk to me because I needed to get through to the patients and make them open up to me. I had to introduce myself to new patients and staff members, lead process groups where patients vent and reflect on their lives at the center, engage and start discussions and learned to let lose with the patients. I understood that if I were to act awkward, then the patients would not discuss and process their lives, which would lead to frustration and perhaps ultimately relapse because I am not doing my best to help them recover and speak about their troubles. I know that if I were to become a lawyer, I would have to speak publicly and try get people to open up to me when it comes to their problems and to retrieve information to process legal cases, interning helped me overcome my anti-social personality somewhat. It help start me on a quest to relax and open up to people without caring what they think about me, a valuable lesson that I am growing more comfortable with.
Through my service at the rehab center, there was a reciprocity of compassion. I showed compassion by wanting to be at the rehab center and wanting to help these women realize that are escape routes to life's problems and it is not too late.
Towards the end of my field study, I noticed that I became attached to some of the patients and I yearned to be able to help them more and reach out. However, some of the women's time at the rehab center was nearing an end and many of them are starting to transition into the sober living housing. I made some friendships along the way and taught some people but I felt that I learned more from them through their kindness, their problems and their stories. I feel that their teachings and my stay at the field site taught me about the workings, problems and politics inside a rehab center more than any course book could."
Written by Allison Dang
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