text:
Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update
Jonna M. Leyrer-Jackson, Amanda M. Acuña, M. Foster Olive
Introduction: Opioid use disorder (OUD) is characterized by compulsive opioid seeking and taking, intense drug craving, and intake of opioids despite negative consequences. The prevalence of OUDs has now reached an all-time high, in parallel with peak rates of fatal opioid-related overdoses, where 15 million individuals worldwide meet the criteria for OUD. Further, in 2020, 120,000 opioid-related deaths were reported worldwide with over 75,000 of those deaths occurring within the United States. Areas covered: In this review, we highlight pharmacotherapies utilized in patients with OUDs, including opioid replacement therapies, and opioid antagonists utilized for opioid overdoses and deterrent of opioid use. We also highlight newer treatments, such as those targeting the neuroimmune system, which are potential new directions for research given the recently established role of opioids in activating neuroinflammatory pathways, as well as over the counter remedies, including kratom, that may mitigate withdrawal. Expert opinion: To effectively treat OUDs, a deeper understanding of the current therapeutics being utilized, their additive effects, and the added involvement of the neuroimmune system are essential. Additionally, a complete understanding of opioid-induced neuronal alterations and therapeutics that target these abnormalities–including the neuroimmune system–is required to develop effective treatments for OUDs.
Expert Opinion on Pharmacotherapy
levo-alpha-acetyl-methadol
pharmacotherapies
Dive into the research topics of 'Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update'. Together they form a unique fingerprint.
Opioid-Related Disorders Medicine & Life Sciences 100%
Opioid Analgesics Medicine & Life Sciences 72%
Mitragyna Medicine & Life Sciences 14%
Therapeutics Medicine & Life Sciences 13%
Opiate Substitution Treatment Medicine & Life Sciences 12%
Narcotic Antagonists Medicine & Life Sciences 9%
Craving Medicine & Life Sciences 9%
Leyrer-Jackson, J. M., Acuña, A. M., & Olive, M. F. (2022). Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update. Expert Opinion on Pharmacotherapy, 23(16), 1819-1830. https://doi.org/10.1080/14656566.2022.2140039
Current and emerging pharmacotherapies for opioid dependence treatments in adults : a comprehensive update. / Leyrer-Jackson, Jonna M.; Acuña, Amanda M.; Olive, M. Foster.
In: Expert Opinion on Pharmacotherapy, Vol. 23, No. 16, 2022, p. 1819-1830.
Leyrer-Jackson, JM, Acuña, AM & Olive, MF 2022, 'Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update', Expert Opinion on Pharmacotherapy, vol. 23, no. 16, pp. 1819-1830. https://doi.org/10.1080/14656566.2022.2140039
Leyrer-Jackson JM, Acuña AM, Olive MF. Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update. Expert Opinion on Pharmacotherapy. 2022;23(16):1819-1830. doi: 10.1080/14656566.2022.2140039
Leyrer-Jackson, Jonna M. ; Acuña, Amanda M. ; Olive, M. Foster. / Current and emerging pharmacotherapies for opioid dependence treatments in adults : a comprehensive update. In: Expert Opinion on Pharmacotherapy. 2022 ; Vol. 23, No. 16. pp. 1819-1830.
@article{a67705d737234e99b86db86c65a27ed1,
title = "Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update",
abstract = "Introduction: Opioid use disorder (OUD) is characterized by compulsive opioid seeking and taking, intense drug craving, and intake of opioids despite negative consequences. The prevalence of OUDs has now reached an all-time high, in parallel with peak rates of fatal opioid-related overdoses, where 15 million individuals worldwide meet the criteria for OUD. Further, in 2020, 120,000 opioid-related deaths were reported worldwide with over 75,000 of those deaths occurring within the United States. Areas covered: In this review, we highlight pharmacotherapies utilized in patients with OUDs, including opioid replacement therapies, and opioid antagonists utilized for opioid overdoses and deterrent of opioid use. We also highlight newer treatments, such as those targeting the neuroimmune system, which are potential new directions for research given the recently established role of opioids in activating neuroinflammatory pathways, as well as over the counter remedies, including kratom, that may mitigate withdrawal. Expert opinion: To effectively treat OUDs, a deeper understanding of the current therapeutics being utilized, their additive effects, and the added involvement of the neuroimmune system are essential. Additionally, a complete understanding of opioid-induced neuronal alterations and therapeutics that target these abnormalities–including the neuroimmune system–is required to develop effective treatments for OUDs.",
keywords = "buprenorphine, kratom, levo-alpha-acetyl-methadol, methadone, naloxone, naltrexone, opioid use disorder, Opioids, pharmacotherapies",
author = "Leyrer-Jackson, {Jonna M.} and Acu{\~n}a, {Amanda M.} and Olive, {M. Foster}",
note = "Funding Information: This paper was funded by National Institute of Health Grant Nos. F32AA027962, DA043172, and AA025590. Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor & Francis Group.",
journal = "Expert Opinion on Pharmacotherapy",
T1 - Current and emerging pharmacotherapies for opioid dependence treatments in adults
T2 - a comprehensive update
AU - Leyrer-Jackson, Jonna M.
AU - Acuña, Amanda M.
AU - Olive, M. Foster
N1 - Funding Information: This paper was funded by National Institute of Health Grant Nos. F32AA027962, DA043172, and AA025590. Publisher Copyright: © 2022 Informa UK Limited, trading as Taylor & Francis Group.
N2 - Introduction: Opioid use disorder (OUD) is characterized by compulsive opioid seeking and taking, intense drug craving, and intake of opioids despite negative consequences. The prevalence of OUDs has now reached an all-time high, in parallel with peak rates of fatal opioid-related overdoses, where 15 million individuals worldwide meet the criteria for OUD. Further, in 2020, 120,000 opioid-related deaths were reported worldwide with over 75,000 of those deaths occurring within the United States. Areas covered: In this review, we highlight pharmacotherapies utilized in patients with OUDs, including opioid replacement therapies, and opioid antagonists utilized for opioid overdoses and deterrent of opioid use. We also highlight newer treatments, such as those targeting the neuroimmune system, which are potential new directions for research given the recently established role of opioids in activating neuroinflammatory pathways, as well as over the counter remedies, including kratom, that may mitigate withdrawal. Expert opinion: To effectively treat OUDs, a deeper understanding of the current therapeutics being utilized, their additive effects, and the added involvement of the neuroimmune system are essential. Additionally, a complete understanding of opioid-induced neuronal alterations and therapeutics that target these abnormalities–including the neuroimmune system–is required to develop effective treatments for OUDs.
AB - Introduction: Opioid use disorder (OUD) is characterized by compulsive opioid seeking and taking, intense drug craving, and intake of opioids despite negative consequences. The prevalence of OUDs has now reached an all-time high, in parallel with peak rates of fatal opioid-related overdoses, where 15 million individuals worldwide meet the criteria for OUD. Further, in 2020, 120,000 opioid-related deaths were reported worldwide with over 75,000 of those deaths occurring within the United States. Areas covered: In this review, we highlight pharmacotherapies utilized in patients with OUDs, including opioid replacement therapies, and opioid antagonists utilized for opioid overdoses and deterrent of opioid use. We also highlight newer treatments, such as those targeting the neuroimmune system, which are potential new directions for research given the recently established role of opioids in activating neuroinflammatory pathways, as well as over the counter remedies, including kratom, that may mitigate withdrawal. Expert opinion: To effectively treat OUDs, a deeper understanding of the current therapeutics being utilized, their additive effects, and the added involvement of the neuroimmune system are essential. Additionally, a complete understanding of opioid-induced neuronal alterations and therapeutics that target these abnormalities–including the neuroimmune system–is required to develop effective treatments for OUDs.
KW - buprenorphine
KW - kratom
KW - levo-alpha-acetyl-methadol
KW - methadone
KW - naloxone
KW - naltrexone
KW - opioid use disorder
KW - Opioids
KW - pharmacotherapies
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy

redpajama_set_name: RedPajamaCommonCrawl


text:
Martin Freeman Joins Marvel's 'Captain America: Civil War'
Marvel.com: "From his roles as Bilbo Baggins and Doctor Watson to Tim in 'The Office,' Martin's range from the dramatic to the comedic has consistently impressed us," said "Captain America: Civil War" Producer Kevin Feige. "We couldn't be more honored or excited to have such a talented actor join the Marvel Cinematic Universe."
"Captain America: Civil War" hits theaters May 6, 2016.


text:
TribeBoost: Grows Your Audience for You
Mosquatch: Shares Great Content For You
ThoughtFlame: Delivers Inspirational Tweets for You
Twitter Retargeting: The Ultimate Guide
By	Kevin Strasser
You may not have even thought of Twitter retargeting. When it comes to social media advertising, Facebook leads the way. But Twitter retargeting can also be a very effective strategy.
Twitter announced another major upgrade to their advertising options — retargeting features.
What Is Retargeting?
Social media advertising is powerful because it allows advertisers to target users based on very specific data such as location, interests, and demographics.
Retargeting takes this one step further. It allows advertisers to target people who have visited their website.
If you are unfamiliar with retargeting, you have probably experienced it and maybe even attributed it to a weird coincidence.
In that case, you may have visited a website and then a few days later saw an ad for that company or the exact product you viewed in your Facebook news feed or on a banner ad on a different site.
It's not a coincidence; it's marketing and retargeting at work.
The Ultimate Guide To Twitter Retargeting
How Does Retargeting Work?
Retargeting on Twitter allows advertisers to collect data from the users who visit their website. The technology uses cookies and code that connects the website to another third-party platform, like Twitter.
When a user visits a website that has integrated Twitter retargeting, a signal is sent to Twitter. The signal then prompts Twitter to show ads related to the website to the user who recently visited the site.
Retargeting prompts an advertising action based on user action. This is a form of behavioral advertising is an effective way to advertise, especially through social media.
Why You Should Set Up Retargeting
Twitter retargeting is powerful because it allows advertisers to target a highly engaged audience — people who have already visited their website and showed interest in their brand, products, or services.
Retargeting on Twitter advertises to a warm lead, which can increase user engagement, reinforce brand recognition, and create a higher ROI.
A variety of platforms make retargeting possible but now, now you can set up retargeting through Twitter. And if you use Twitter advertising, you should consider utilizing this new tool.
#Retargeting has a good success rate, increases conversions and has a higher #ROI than other marketing campaigns. pic.twitter.com/HLAMLiCVQS
— Simone Bertesina (@bertweb79) August 4, 2015
What To Do Before You Set up a Twitter Retargeting Campaign
As you set up your retargeting campaign, you will need to make a few decisions about your campaign settings. So before you get started, take some time to plan your campaign.
Define Your Goals — What is the main goal of your campaign? Twitter will prompt you to select a goal such as:
Increase site visits
Generate a purchase
Generate a download
Increase number of sign ups
There is also a custom option if you want to be more specific about your goals. But for your first couple of campaigns, it might be better to keep it simple.
Define Your Audience — Once you identify the goal, you can define the audience you want to target for the campaign. Describe the person who you want to take the action. Having a solid idea about your audience will help as you create your ad content and define your audience.
Prepare for the Technical Stuff — Once you set up a website tag, Twitter will generate a code that needs to be installed in the backend of your website. Twitter provides directions for how to set up your tracking code.
How to Set Up a Twitter Retargeting Tag
Before you set up a campaign, set up your targeting tag.
1.Go to Twitter Ads. This process will generate the code that will need to be added to your website. Go to ads.twitter.com > Tools > Conversion Tracking.
2. Create a website tag. Name the tag, select the conversion you want to track, and check the box to "Create a tailored audience."
Selecting the conversion you want to track will help Twitter collect data to help you measure the results of your campaign.
By checking the box to create a tailored audience, you are telling Twitter to monitor who visits your website and create a custom audience of those users.
Twitter will create a tailored audience of people who have visited your site. Once Twitter has collected enough data, you can deliver ads to that audience.
You can also adjust additional conversion settings that relate to timeframes or you can leave the default options as is.
3. Add the code to your site. At this point, Twitter will generate the code that needs to be added before the closing HTML </body> tag of your website.
Once you add this to your site, Twitter will be able to collect conversion and audience data from your website.
How to Set Up Retargeting Campaign on Twitter
Once your code is set up, you can set up your campaign:
1. Set up a campaign. Go to ads.twitter.com > Campaigns > Create New Campaign > Website Clicks or Conversions. On the next page, give your campaign a descriptive name, set the run dates, and select the conversion tag you set up in prior steps.
2. Build the creative. Set up the Twitter Card that will serve as the creative for your ad. Or you can use past tweets. Think about your defined audience and create something that speaks directly to them and their needs.
3. Set the targeting options. In this section, you can define the audience that you want your ad to target and where you want your ad to show.
If you added a retargeting code to your website and it has collected enough data, you can add your tailored audience.
You can also tell Twitter to show your ad to people who have visited your site and people who are similar to them. By selecting the "expand research by targeting similar users," you expand your reach by telling
Twitter to display your ad to others who are likely to be interested in your brand, product, or services.
If you haven't had your code installed long enough to build a tailored audience, you can identify the specific users you want to target. Twitter will show you how big your audience size will be based on your settings.
4. Set your budget. Set the total amount of money you would like to spend each day of your Twitter ad campaign. You can also set a total amount for the campaign to ensure that your ad turns off after a set amount of money has been spent.
Pulling It All Together
Twitter's new retargeting tools can help you maximize your advertising efforts. You can now target a very specific audience and better measure your results.
To get the best results with Twitter retargeting, install a tracking code and set up a campaign to a highly targeted, defined audience.
Once you send traffic to your site, connect with those users again by setting up a campaign to advertise to them in the next 15-30 days.
Then watch your engagement and Twitter advertising ROI begin to grow.
Kevin is the Founder and CEO of TribeBoost.
The Key to Twitter Marketing is Being Human
The Ultimate Guide to Twitter Analytics
The Ultimate Guide to an Amazing Twitter Profile
The Ultimate Guide to Marketing Automation for Startups
10 Easy Growth Hacks and How to Apply Them
7 Quick & Easy B2B Growth Hacking Strategies
© Copyright 2012-2018 TribeBoost


text:
Q: How to save a PDF document in android studio for Android 10+ I'm trying to save this PDf file in external storage but it only works for android 9 and below since something was removed for Android 10+. How can i save the file for android 10+.Kinda new with app dev so didn't understand the documentation.
                myPdfDocument.finishPage(myPage1);

                File file = new File(Environment.getExternalStorageDirectory(),"Client.pdf");

                try {
                    myPdfDocument.writeTo(new FileOutputStream(file));
                } catch (IOException e) {
                    e.printStackTrace();
                }
                finally {
                    Snackbar.make(view, "PDF Created at" + Environment.getExternalStorageDirectory()+"Client.pdf", Snackbar.LENGTH_LONG)
                            .setAction("Action", null).show();
                }
                myPdfDocument.close();

A: android:requestLegacyExternalStorage="true"

add this in your manifest under application tag.
WRITE_EXTERNAL_STORAGE when targeting Android 10
also read this

redpajama_set_name: RedPajamaStackExchange


text:
About Staff Investigations Exams/Reports Terms Fees Stats Contacts
Bradford County, PA Coroner's Office
Coroner Carman is a Certified Medical Investigator through the American Board of Forensic Medicine. Coroner Carman passed his American Board of Medicolegal Death Investigators board examination in Nevada in 2009, and is now a board certified Medicolegal Death Investigator. Coroner Carman participated at St. Joseph's University in Philadelphia, Pa., completing Advanced Topics in Forensic Science; Investigating Religious and Ritualistic Crime. Coroner Carman has had a multitude of forensic training including Forensic Photography, Advanced Criminalistics, Criminal Investigation, Advanced Interviewing and Interrogation, Crime Scene Reconstruction, and several other topics. Coroner Carman participated with a short course on Forensic Anthropology at Mercyhurst University in Erie, Pa. Coroner Carman is certified in Advanced Practical Homicide Investigation, and remains a member of the Pa. Homicide Investigators Association.
The Coroners office is a twenty-four hour a day, 7 days a week office, mandated by Commonwealth law, to investigate and determine causation and manner of death. Our office staff investigates cases of homicide, suicide, accident, and all natural deaths that are sudden, unexpected or medically unattended. Our office is open to the public from 09:00 - 17:00 Monday thru Friday.
129 Canton Street, Troy, Pa. 16947
Bradford County, PA Coroner's Office bradfordcountycoroner.com


This page was last updated in February 2017.
Thank you for volunteering to run an I2P reseed server. "Reseeding" is our term for bootstrapping new routers into the network. New routers fetch a bundle of peer references, or "router infos", from one or more of a hardcoded list of HTTPS URLs.
The reseed servers are under periodic attacks and DDoS attempts, and from other buggy I2P implementations and botnets. This necessitates that you run fail2ban or an equivalent solution.
When your setup is complete and ready for testing, we will need the HTTPS URL, the SSL public key certificate, and the "su3" bundle public key. After testing is complete, these will be added to the hardcoded entries in the Java and C++ routers in the next release, and you will start seeing traffic. We also will need your email address so we may continue to contact you about reseed administration issues. The email will not be made public but will be known to the other reseed operators. You should expect that your nick or name and its association with that URL or IP will become public.
Modest financial support may be available to those running reseed servers. This support would be in partial reimbursement for your server costs. Support will not be paid in advance and will probably not cover all your expenses. Support is only available to those who have been running reseed servers in good standing for several months, and is based on actual need.
If you would like to discuss support, please contact echelon and CC: backup.
Our reseed coordinator is "backup" and he may be contacted at backup at mail.i2p or backup at i2pmail.org. Unfortunately, he is not generally on IRC. The reseed setup is somewhat specialized, and you should direct most questions to him.
A Go implementation that includes the web server and all the scripts. This is the recommended solution.
For further information, read the information at the following links, and then contact backup. Thank you!
Some parts of this how-to are copied from zzz.i2p and are modified.
Fetching individual RI (dat-files -the legacy/old style-) is not part of this how-to.
Questions can be placed on zzz.i2p - in the Reseeding sub-forum.
Public reseed servers are necessary to bootstrap into the I2P net. New installed I2P routers needs one-time about one hundred RouterInfo's (RI) as jump start.
RI contains IP and Port from other I2P routers and are stored in dat-files in the netDB folder.
A random bunch of dat-files from the netDB are zipped, then signed to a su3-file and finally offered to I2P routers seeking reseed service.
To secure bootstrap and enable a trusted start, HTTPS/TLS and signed su3-files are mandatory.
It is essential not to publish all RI from netDB, or all RI to one client.
This How-to is tested with Ubuntu/Debian as well as FreeBSD. The web server has to be public reachable from all over the world, an eepsite inside I2P can be setup in addition. Also frequent or infrequent attempts to scrape all your reseed files, and of course attacks on your server. The web server doesn't need to listen at default SSL/TLS port 443 - any other port can be used for obfuscation.
Note: Visit http://reseed.i2p and download a pre-build x86_64 binary, so you can skip step 2+3.
lighttpd is no longer supported due to a limitation with the 'X-Forwarded-For' HTTP Header. Please use Apache or nginx.
Additionally, ensure that your webserver uses these suggested settings for Strong SSL Security (visit CipherLi.st for the latest settings). Sample SSL settings are provided in section 4.5 Reverse-Proxy Setup.
Note: i2p-tool has also an build-in standalone webserver with TLS support which can be used without a webserver. Please contact me (backup at mail.i2p.de) if you need help, or stop by #i2p-dev on IRC2P and talk to other reseed operators.
Enter your new reseed-url and delete all others, hit "Save changes and reseed now"
Check the I2P logs for "Reseed got 77 router infos from ... with 0 errors, Reseed complete, 77 received"
The previous steps for reseeding involves many steps, scripts and programs. Most of them are easy and plain straight forward, but overall you can call it a little confusing.
If you already have an SSL-certificate and su3-signer-key you can reuse them, see one of the following chapter.
For testing and new reseeders the required certs and keys are created automatically at first start.
Also take a look at the content and the naming scheme of these pem and crt files.
Of course you need an up-to-date netDB folder with routerinfos from a running I2P router. I2P does not have to be running on the same machine as this reseed binary. In this case you can setup a cronjob to transfer the netDB from the I2P machine to the reseed machine.
Matt's go solution can be used in parallel next to an already running http-server. For this leave the http-server running at normal port 80 and 443, and configure Go solution too use another port, e.g. port 8443.
which should state something like: "go version go1.4.2"
2015/03/15 12:28:25 Building 200 su3 files each containing 75 out of 3180 routerInfos.
So you can now test to reach the server at port 8443, see a previous chapter about proper testing.
Every port between 1024 and 49151 is fine for I2P.
If you want to use the privileged (https-default) port 443, create a port redirect, e.g.
Both of the certificates (*.crt) will need to be sent to the reseed maintainer in order for your reseed server to be included in the standard I2P package.
4. Draft for Startup Script "seedserver"
Update the header "# Your settings" with your individual settings.
If this is working fine, you can put the script in your personal crontab, to run it by auto-start and to do logrotes simply by restarting it regularly once a week to avoid too big logfiles. If you already reboot your server regularly, you can skip of course the "restart" command line.
Save and close the editor. It would be good to check if this is properly working when you reboot your machine.
echo "$tool running, pid $(pgrep "$tool")"
You can run i2p-tools also behind your normal web-server (reverse-proxy).
The web-server handles the TLS handshake, encryption, SSL Certificate and the logfiles. But you don't need the scripts su3.php and the shell cronjob for creating su3-files. i2p-tools is running "behind" the web-server, without TLS management, only bind to local interface 127.0.0.1 and is handling complete building and handling of su3-files.
Additionally, ensure that your webserver uses these suggested settings for Strong SSL Security (visit CipherLi.st for the latest settings). A sample configuration is provided below.
This describes how to convert your existing Java keystore with your su3 signing key to a plain crt- and pem-file. This is only needed, when you already have a Java keystore and want to use Go solution. If you create new keys+certs with matt's solution you can skip this chapter!
And a "storage" password, which is most probably default "changeit".
The update/exchange of an already existing self-signed certificates has to be correct timed on server *and* client side. Considering thousands of clients (many with older I2P version) the exchange will not be seamless possible and will have very bad impact on many clients: reseed won't work for them.
Replace "--no-check-certificate" with "--ca-certificate=~/i2p/certificates/ssl/your-server.com.crt" which contains the path to your local public SSL-certificate to check also your ssl-certificate chain.
The su3-files can be downloaded?
And is always the same for one client-IP?
Other client-IP's gets another file?
Clients has no direct access to complete folder e.g. https://your-server.com/su3/ ?
Add the new reseed host e.g. "https://your-server.com/" *without* trailing "i2pseeds.su3"
Clear netdb: empty folder ./i2p/netDb.
Feel free to contact backup at mail.i2p in case of questions or problems or post your question at zzz's forum in the reseed section.


During this year's Earth Day celebrations, Wildsight ("Wildsight works to maintain biodiversity and healthy human communities in Canada's Columbia and Rocky Mountains ecoregion. We are focused on three core areas: the southern Rockies, the upper Columbia River Valley, and the Columbia Mountains. This ecoregion provides critical genetic connectivity for western North America's wildlife populations") hosted Downtown Goes Wild in Cranbrook's Rotary Park.


text:
Q: How to create table of contents for an Excel file generated by C#? I have to implement an Excel export in an application where the exported Excel file should contain something like a table of contents on the second sheet.
This sheet should refer to the other sheets with page numbers - so if the customer prints out the Excel file, they can use this table of contents.
Given some assumptions on the page size, margins, etc., does anyone have an idea on what kind of library should I use to fulfill this requirement?
Or the only possible way of doing this is calculating the page numbers with VBA macros?

A: If anyone is interested, it seems that I can use Aspose.Cells to calculate the page numbers for the table of contents:
var workbook = new Workbook("Erstfassung.xls");
var pagesSoFar = 0;

foreach (var worksheet in workbook.Worksheets)
{
    var pageCount = worksheet.GetPrintingPageBreaks(new ImageOrPrintOptions()).Length;
    Console.WriteLine($"{worksheet.Name} - ({pageCount} long), starts from {pagesSoFar}");
    pagesSoFar += pageCount;
}


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1 "These things I have spoken to you, that you should not be made to stumble. 2 They will put you out of the synagogues; yes, the time is coming that whoever kills you will think that he offers God service. 3 And these things they will do to you because they have not known the Father nor Me. 4 But these things I have told you, that when the time comes, you may remember that I told you of them.


If a CPAP machine is decided to be the best option, you'll likely have to possess a follow-up sleep titration research in which you will rest at a slumber clinic overnight although wearing numerous CPAP masks and employing a handful of various machines that may be particularly calibrated towards the air pressure needed to crystal clear your airway blockage devoid of resulting in any disturbance or distress on your snooze.
Besides donning a mask which is connected to your machine, you happen to be fundamentally returned to a traditional technique for sleeping Each and every night. This is why Medical practitioners prescribe CPAP therapy for those with rest apnea.
Hail storm damages hundreds of acres of watermelon plants.


text:
Big long haired dog
The big long-haired dog is an extinct hybrid dog species that may have been part of a type of ancient wolf-like dog in the family Canidae. It is a mixture of a large type of the modern European and Asian wolves and a small type of the modern Arctic wolf (see table). It has been proposed as a probable ancestor of modern Arctic dogs, most of which are domesticated grey wolves.
The largest specimens of the species that have been studied so far measure at least at the shoulder. Some have been put at over and are estimated to have weighed more than . It also has been known to exceed in height, at the shoulder. Although not as large as its direct ancestors, the dog appears to be a fairly heavy wolf. The size may have allowed it to survive until the end of the last glacial maximum, about 14,500 years ago.
Some accounts say that the big long-haired dogs had a slightly different skull shape, and a larger head. They are also thought to have had large eyes, and a prominent and rounded forehead. These claims have not been supported by recent physical descriptions.
The species has been distinguished from the modern wolves by its much larger size. This trait is thought to have arisen from hybridisation between a larger type of wolf and a smaller type of wolf. In this respect, the species appears to have behaved like a dog. The modern wolf is generally accepted to have originated between the early to mid-Holocene epochs. The ancestry of the species is also believed to be unknown.
The first fossil specimens of the species were found in the area of the Bering Sea, to the north of Siberia, about from Novosibirsk, in the Russian Far East. Specimens have also been found in the eastern part of the Kola Peninsula. There are some reports that it has been found in Greenland, however, most studies say that this information is either unreliable or not based on actual fossil specimens. A later study suggested that the first fossil remains are not from Greenland, but from the Novaya Zemlya archipelago in the Barents Sea. During the period that it inhabited Novaya Zemlya, the species seems to have been widespread in the northern part of Eurasia. At the beginning of the Holocene, the species had an estimated range of .
The specimen found in Siberia was described as the "largest known Canidae fossil from the Holocene". The individual found in Novaya Zemlya was about tall at the shoulders, and long from its shoulder to the tip of its tail. It weighed . This size meant that the animal could easily have been the size of a modern grey wolf. However, other descriptions suggest that it was a larger wolf than the modern ones. Other studies describe it as slightly larger than the modern wolf. The length of its muzzle is about for the northern specimen and for the Novaya Zemlya specimen. This suggests that the species had a very short muzzle. The teeth of the fossil canids also suggest that they were not the modern size of the species, as they are similar to the teeth of the wolf-like Canis parinus, and have a different pattern of tooth shape. The northern specimen is considered to be more similar to the modern wolf than the specimen from Novaya Zemlya.
The fossil from Siberia is composed of mostly soft tissue, and lacks bones. Only a few areas of bone have been found. These bone locations were most likely from the shoulder region, and possibly the lower leg. The bone locations that have been found in the Siberian specimen suggest that it had a longer snout than modern wolves. The teeth of the fossil specimens show a strong resemblance to the teeth of the wolf-like Canis parinus.
Habitat and behavior
The location of the fossil suggest that this is a cave wolf, and the cave is thought to be relatively new. The cave is thought to have been around in diameter. Studies have also shown that the wolf was most likely nocturnal. This was determined by the fact that large amounts of animal remains and scat were found in the cave, which is more likely to be found by nocturnal animals. It is also more likely to find evidence of nocturnal species if the species is still living in the area, rather than having died a long time ago. This shows that the wolf was nocturnal, and spent its life in caves. It lived in the northern parts of Siberia, and in Novaya Zemlya.
The environment of the cave has been determined by the location and size of the wolf remains. A study done on the bone locations showed that these bones were placed in specific locations within the cave. This indicates that the location of the wolf was a consistent area.
In modern times, wolf-like canines have been found in many parts of Eurasia. This shows that cave wolves were the ancestors of modern day wolves. It is theorized that the cave wolf was one of the ancestors that led to the development of modern day wolves, and the fossils show that this is the case. These canines have a similar appearance to modern day wolves, and it is believed that this was the common ancestor of modern day wolves. Although this is the case, there is still some differences. This is most likely due to changes in the environment, or due to mutations. The cave wolf is more distant from wolves found in the Pleistocene than those found today. They are believed to have started to separate at a later time than the caves were found in. This may be due to changes in the environment. Some mutations occurred due to a change in environment. These changes occurred in the Pleistocene and made the wolf to start to adapt.
Category:Prehistoric canines
Category:Prehistoric mammals of Europe
Category:Early Canine fossils
Category:Fossil taxa of Europe
Category:Pleistocene carnivorans
Category:Prehistoric mammals of Asia
Category:Fossil taxa described in 1964
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Part of our gorgeous 'Glitz' range, this Birthday Glitz Star Prism Balloon '21' (Black/Silver) is will look fabulous at your 21st birthday. Pack includes 1 x Glitz birthday star prism foil balloon (20" diameter) in black and silver with 'Happy 21st Birthday' message. Helium required for inflation. Once inflated balloon should remain floating for up to five days. Be sure to check out the rest of the Glitz range to coordinate the look at your celebration.


text:
Dallas to mark 50th anniversary of JFK's assassination with memorial ceremony
Nov. 21, 2012, 11:59 AM UTC
By Ken Kalthoff, NBCDFW.com
Dallas is planning a major public memorial ceremony in 2013 to mark the 50th anniversary of President John F. Kennedy's assassination at Dealey Plaza, it was announced Tuesday.
"The tone is very important," Dallas Mayor Mike Rawlings said. "We want to mark this day by remembering a great president with a sense of dignity and honor he deserves. The 50th will be a serious, respectful and understated public memorial."
Rawlings said public donations are being taken to cover the cost and no tax money will be used for the event, which will take place on Nov. 22, 2013.
Tickets will be issued for the Dealey Plaza event because organizers expect more people will want to attend than the plaza can safely hold.
Secret tapes of JFK's last days released
The service will include a moment of silence at 12:25 p.m., the time the shots rang out.
A committee appointed by Rawlings is planning the memorial, some details of which are already on an official website.
"I'll never forget the faces of all the weeping women and the men who were just stricken, I mean you can imagine how shocking this was," said Dallas Citizens Council leader Ruth Altshuler, the committee chairperson.
Another murder that same November 1963 day was the killing of Dallas police officer J.D. Tippit who was on patrol in Oak Cliff looking for the president's killer.
Witnesses said Lee Harvey Oswald gunned Tippit down before Oswald was eventually arrested at the Texas Theater.
More news from NBCDFW.com
Nearly 49 years later, a memorial to Officer Tippit was unveiled Tuesday at the corner where the shooting occurred.
Attending the dedication was former Dallas police detective Jim Leavelle, who was assigned to Tippit's case. "I think it's a great honor to Tippit, and he deserves it, and I'm just glad I could be alive to see it," Leavelle said.
Tippit's widow Marie also attended the dedication ceremony. "I think it should be remembered," she said "The president was killed here and Jay was killed here trying to apprehend the killer of the president so I think it should be remembered."
Ken Kalthoff, NBCDFW.com


Pennsylvania's Department of Environmental Protection (DEP) publishes regular reports on the impacts of climate change specific to Pennsylvania. The 2015 Climate Impact Assessment report found that Pennsylvania has warmed by 1° C (1.8°F) in the last 110 years and that the impacts of climate change will be felt throughout the state. The full report, along with periodic updates can be found on Pennsylvania's DEP webpage.


Have the perfect Christmas this year with a real Christmas tree. Nothing beats having a real Christmas tree at Christmas, the look the feel the smell. So at Millets Farm Garden Centre - Frosts in Abingdon, they are stocking real Christmas trees to help make your Christmas a magical one. There are different varieties of real Christmas trees so that is why the staff at Millets Farm Garden Centre - Frosts will be happy to help you choose the one that will be right for you. Visit Millets Farm Garden Centre - Frosts in Abingdon soon to pick up your real Christmas tree.


text:
Q: Twig for loop array key I'm new to twig, facing some issue on for loop.
    For loop how to get key
{% set data = {pounds: {all: {year: {2012: 123,2013:234,2014:500}}}} %}
{% set i = {0:2012,1:2013,2:2014} %}
{% for years,value in data.millions.all %}
  {% for key,val in i %}
   {{ value.val }}
  {% endfor %}
{% endfor %}

After execute i got below error
#1    Type    Twig_Error_Runtime
#2    Message    Key "val" for array with keys "2012, 2013, 2014" does not exist.
#3    At    twigfiddle:environment/KGoFPP6aiGA8cNzG/twig/main.twig:5

Expected output
123
234
500

Ref : https://twigfiddle.com/1c6rsv
Help is appreciated


Only two families have owned and lived in Glenmore: the Branners and Jarnagins. Both are well-known in Jefferson County. Also, both families have connections to almost every pioneer family in the surrounding region.
John Roper Branner, who built the house, was the grandson of Michael and Christina Branner, who came from Virginia in 1799. Their son, George, married Mary Ann Roper. George and Mary Ann were John Roper Branner's parents. John Roper Branner started out in business with his brother, William, in a little store in the basement of the Roper Tavern in Dandridge. John left William to tend to the store and went to Mossy Creek, about ten miles away.
In 1882, the Branners sold their home to Milton Preston Jarnagin, Sr. He was a grandson of Thomas Jarnagin, one of the first settlers in Jefferson County. In 1783, Thomas came from the Watauga settlement to live at the mouth of Long Creek. Milton Preston Jarnagin was the first graduate of Maryville College in 1846. After graduation, Milton studied law with his cousin, Spencer Jarnagin, in Athens, Tennessee. Milton eventually moved to Memphis, where he had a successful career. He retired and moved back to Mossy Creek, where he bought the Branner home. Milton changed the name of the house to "Glenmore," the name of his first son, who died as a baby.
Mossy Creek Depot, as seen from Glenmore circa 1900. This was a very good location, and it was near the stately homes of other Branner relatives. From 1868-1869, John Roper Branner built his dream house, which he called "The Oaks." Following Emancipation, several of Branner's former slaves continued to work for the family and were the primary masons, carpenters, and laborers in building his new home. Descendants of those former slaves, many of whom took the Branner surname, return periodically to touch a piece of their ancestral heritage. Sadly, John Roper Branner never got to live in the house. He died shortly before it was completed. John's widow, Deborah (neé Massengill), had to oversee completion of the house and move her children there. Afterward, John's brother, Joseph, ran the Branner Institute for Young Ladies in the house.
In February, 1970, the 101-year-old house and surrounding property were saved from the auction block and developer's bulldozer when the heirs of Milton Preston Jarnagin, Sr., presented the site to the Jefferson County Chapter of the Association for the Preservation of Tennessee Antiquities (APTA).
Glenmore has undergone several phases of restoration since the APTA acquired it.


Hopefully French speakers worldwide don't mind having a car called the Audi Turd.
The e-tron does look awesome, but I don't know if I won't always see it and think to myself, There goes an Audi Turd. It starts at just under $75,000 so I will definitely be thinking to myself, There goes one rich m'fer.


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Manara Library Volume 2 – Comics Etc.
The second volume of Manara Library, in a paperback edition at last! This volume features the enthralling historical epic El Gaucho, the second of Manara's storied collaborations with his mentor, Hugo Pratt, as well as Trial by Jury, a series of captivating shorts in which some of history's most notorious figures undergo mock trials. The only comprehensive English collection of Manara's work.