Posted by Dr. Krishna Kumari Challa on November 15, 2018 at 7:05am in Science Simplified!
Q : Can placebo and nocebo effects affect clinical trials and research?
Krishna : Yes, they can, if you don't take precautions. That is why double blind trials are so important. Not telling patients what they are getting, a real drug or a placebo is important to not to screw up your results. You don't know whether the drug is actually working or it is the placebo effect that is making the patient feel better. If the patient feels better even after taking just a sugar pill, you cannot attribute medicinal properties to sugar pills.
But still that is how, sham medicine who prey on the desperate and, if they are lucky, fool people into feeling better, works!
I f I ask one of my aunts whether Homeopathic medicines she 's taking 's working, she says, "YES" emphatically despite the evidence*(1) we have to the contrary.
That is why depression, back pain, chemotherapy-related malaise, migraine, post-traumatic stress disorder: The list of conditions that respond to placebos — as well as they do to drugs, with some patients — is long and growing.
That is why identifying the molecules in the drugs that really work, and studying how they work (actual mechanism) in different set of conditions is extremely important to pin point the accuracy. Understanding the body's healing mechanisms is important too. Because 'feeling better' does not actually 'cure' you of deadly diseases like cancer. Placebos might work for migraine but don't work for malaria!
Researchers need to assume that the placebo effect is part of every drug effect, and that drugs can be said to work only to the extent that they worked better than placebos. An accurate measure of drug efficacy would require comparing the response of patients taking it with that of patients taking placebos; the drug effect could then be calculated by subtracting the placebo response from the overall response.
Q: What is the reason for placebos working?
Krishna: Earlier most of these reasons have traditionally been linked to psychology, based on mechanisms like expectancy — the set of beliefs that a person brings into treatment, the comfort and reassurance s/he gets while dealing with a 'doctor' that talks 'sweetly and softly'. The 'rituals' embedded in the doctor-patient encounter are fundamental to the placebo effect, where a suffering person puts his or her fate in the hands of a trusted healer. The placebo effect is a biological response to an act of caring.
It is like a baby getting comfort from her mother's sweet talk (sing-songy way) and the action of arms-cradling. The baby stops crying! Isn't that a miracle?!
But placebo effect responses vary from person to person. That made scientists think different mechanisms 're at play. An enzyme called COMT affected people's response to pain and painkillers. Levels of that enzyme, researchers found, were also correlated with Parkinson's disease, depression and schizophrenia, and in clinical trials people with those conditions had shown a strong placebo response. COMT was also correlated with pain response — another area with significant placebo effects. It is not possible to assay levels of COMT directly in a living brain, but there is a snippet of the genome called rs4680 that governs the production of the enzyme, and that varies from one person to another: One variant predicts low levels of COMT, while another predicts high levels. When scientists analyzed the I.B.S. patients' DNA, they found a distinct trend. Those with the high-COMT variant had the weakest placebo responses, and those with the opposite variant had the strongest. These effects were compounded by the amount of interaction each patient got: For instance, low-COMT, high-interaction patients fared best of all, but the low-COMT subjects who were placed in the no-treatment group did worse than the other genotypes in that group. They were, in other words, more sensitive to the impact of the relationship with the healer.
Scientists also found that the rs4680 gene snippet is one of a group that governs the production of COMT, and COMT is one of a number of enzymes that determine levels of catecholamines, a group of brain chemicals that includes dopamine and epinephrine. (Low COMT tends to mean higher levels of dopamine, and vice versa.) Hall points out that the catecholamines are associated with stress, as well as with reward and good feeling, which bolsters the possibility that the placebome ( how genomics might influence the role of the placebo in patient care and clinical research) plays an important role in illness and health, especially in the chronic, stress-related conditions that are most susceptible to placebo effects.
The new approach, therefore, is - the placebo effect is not just some constant to be subtracted from the drug effect but an intrinsic part of a complex interaction among genes, drugs and mind.
Q: Why do we get scientific explanations and data evidence to pseudo-science too?
While collecting data for pseudo-science, the opposite for data collection for genuine science happens. First the 'researcher' comes to a conclusion. Like for example, nose rings protect you from microbes entering your nose ( this is a genuine pseudo-scientific explanation given by some for using nose rings by women and we proved it wrong too!). Even before verifying it, his belief drives him to collect data or interpret what he found that supports his conclusion.
You hear of someone predicting the future correctly using astrology or palmistry - and for some reason that weighs more heavily than every other time they didn't! In other words - a broken clock is right twice a day. If you take a large enough data sample, something weirdly specific is going to happen, and if you then throw out every failed attempt - it looks like this "weird stuff" happens - when actually it's just a quirk of large sets of data.
I read a report in which some researchers started collecting data for the cause of cancer. When the data was analyzed, strangely, the colour of the socks people used could be linked to cancer! How?
People wearing red socks got cancer more frequently! Funny! There is actually no link between the red colour or any colour or socks in the first place to the cause of cancer. But still if you collect large amount of data it shows some strange patterns and can be interpreted in any way you want. You can connect unrelated things and report it using your numbers as evidence to confirm your beliefs or conclusions! That is how pseudo-science works.
Scientists have to train for very long periods to be good at data collection - and then we have to train ourselves to only look at what is there using our knowledge - not what our human senses or emotions are telling us, because they lie more often than not.
Q:Why is the rocket science the most difficult of all fields of science?
Krishna: If you really know what cancer science is, you will rethink your assumption! Recently when a physicist came to know about why it is difficult to find a cure to cancer, he reacted in this way: "Oh my, rocket science is damn easier and very primitive when compared to this!"
Rocket science is not the most difficult field in science. Biology is! Because it is the most complex system Nature has put before us and thrown a challenge at us to test our intelligence!
Q: Who or what controls science and scientific research?
There are multiple groups that issue guidelines, or education programs, or host development groups on scientific method and methodology: Professional groups focused on specific areas of knowledge or practice (like the NIH, AMA and AAMC for medicine). International groups, often including multiple professional areas, that also exist to arrange conferences and create communication tools for development of the sciences. Universities and major research institutes.
Journals that publish science papers too somewhat control how science is conducted. Papers won't be published if peer reviewers see that your research used poor methodologies. Papers will be criticized and your work will not be cited or picked up by other scientist if your reasoning, supporting facts or analysis is illogical, insufficient or does not deal properly with the accumulated understanding and practices in your field. You will lose funding if your lab and other efforts are sloppy, not properly documented, violate best practices, findings are not recreatable, and so on.If you present findings or argue for research agendas that are not soundly structured or are based on unsupported science, that contain false data or inaccurately characterizes the current consensus, then you will lose all reputation with others in your field and that can literally end your ability to practice scientific research (which is a highly collaborative effort) or to have any impact with "research" you conduct and fund entirely on your own. If you have a history of sound research/publication/teaching, but then start mis-representing your area of study in the popular media, or advocating new ideas without building a basis for them in the professional journals and conferences, or use your credentials in one field to advocate in a different field, then you will lose reputation and suffer the consequences above.
Q: Is Neil deGrasse Tyson overrated?
Krishna: Science is not finished until it's communicated.
"Telling people about science is just as important as conducting the science".
I don't think Neil de Grasse Tyson is overrated. We need science communicators to finish the other half of work of science. Without science communicators science cannot reach common people. As it is most people don't know what is going on in the labs around the world and how it can help them. Then vested interests take charge and spread misinformation that might cause severe harm to the societies we live in. Without the help of science communicators that try to bring light to the world outside , the world becomes darker place with all the light concentrated only in the labs. Communicators are helping the world in negotiating the science maze successfully.
Science communicators around the world are doing a great job to bring sanity to the deranged societies we live in. Give them a big applause.
After interacting with several people on the street, I felt, their perception of science and scientists was very interesting to notice.
Some told me that science was beyond their understanding and they, therefore, place it at unreachable heights! (So I painted it on the top of a mountain). Some said that the scientists lived in the domains of their own and were inaccessible to them! (The fort represents this perception). According to them the doors of the world of science are closed to a layman! The only connection from the scientific world to the common man's world is through media! Media interprets science in its own language and therefore cannot always be considered as correct and a gap always remains between the scientific and ordinary worlds. So I painted this picture of common man's sketch of science with media people in two small houses at the door of the "Fort of Science"!
However, majority of the people I came across agreed that scientists try their best to spread light around the world and remove darkness.
Q: what do scientists feel other people understood about them?
Krishna: Understood about them, not much.
Understood about their science, a lot. That is why science communication became a special branch of science.
Science is not finished until it's communicated.
We need science communicators to finish the other half of work of science. Without science communicators science cannot reach common people. As it is most people don't know what is going on in the labs around the world and how it can help them. Then vested interests take charge and spread misinformation that might cause severe harm to the societies we live in. Without the help of science communicators that try to bring light to the world outside , the world becomes darker place with all the light concentrated only in the labs. Communicators are helping the world in negotiating the science maze successfully.
Q: What is the scientific reason behind a baby's complete head shave in India?
Krishna: It is based on culture, not science.
The 'scientific reasons' given by people like 'The shaving helps to regrow a thicker shaft of hair. It thus promotes hair growth' or "stimulate proper growth of the brain and nerves of baby" are wrong. Shaving doesn't help hair to regrow thick. The rough ends after a shave make you think so, that's all. As the conditions that control the growth and diameter of your baby's hair play out in the scalp itself, shaving his head will not have any effect on his hair growth. Proper growth of the brain depends on nutrition, not on hair.
There is simply no scientific evidence to suggest that this practice is helpful at all. Therefore, the answer to the Q 'Does shaving your baby's head encourage hair growth? is an emphatic "NO".
A baby's scalp will be tender. The top of his head, called the fontanelle, is especially soft because his skull bones have not fully knitted together. Hair protects it actually. Therefore delaying the cultural practices until the baby's skull is fully strengthened is actually recommended by experts. Hair and scalp hygiene is important to help your child develop a healthy head of hair. Experts advise parents to wash their baby's scalp regularly.
The only reason I can think of that could be correct is , getting rid of head lice, obtained from their mothers or any other members of their family. But as soon as the hair grows, these pests can return. Therefore, it is only a short term solution.
My parents told me my head was never shaven. I never faced any harm because of this.
Q: Does keeping animals at home can have adverse consequences?
Krishna: Heard about a thing called zoonoses, the diseases we get from animals? Whether the animal is friend or food or foe, it can carry dangerous diseases!
No doubt, animals make us feel better. They actually contribute to our health. People who keep pets tend to have lower cholesterol levels and lower blood pressure. They tend to get more exercise and to feel less lonely.
However, pets and other animals can get sick. And some of these illnesses can be quite dangerous. If they are not treated, these can be passed on to human beings. Rabies, tularemia, plague, monkeypox, listeria, anthrax, ... these are diseases that are very serious if one gets them.
Recent research (2) has shown that keeping animals such as poultry, which can be disease carriers, free range in the home can contribute to childhood diseases that exacerbate malnutrition.
Q: I have a craving for Fuller's Earth. Why is this and how can I get rid of this?
Krishna: There is a condition called PICA. It is an eating disorder that involves eating items that are not typically thought of as food and that do not contain significant nutritional value like dirt, soil, paint, chalk, starch, charcoal and things like that.
PICA is mainly observed in children, pregnant women and people with mental disorders.
However, medical practitioners usually associate it with mineral or nutrient deficiencies like calcium and iron. Therefore, the first-line treatment for pica involves testing for mineral or nutrient deficiencies and correcting those. In many cases, concerning eating behaviours disappear as deficiencies are corrected. If the behaviours aren't caused by malnutrition or don't stop after nutritional treatment, a variety of behavioral interventions are available. Scientists have developed several different effective interventions, including redirecting the person's attention away from the desired object and rewarding them for discarding or setting down the non-food item.
Consult a doctor to get rid of this problem of yours.
Q: Who knows better, doctors or scientists?
Krishna: "Knowing better" depends on the quantity and quality of knowledge acquired by a person, not on profession.
Without scientists finding out something through thorough research, nobody can acquire genuine knowledge. That is why more and more doctors are getting into clinical research these days. Almost all the major hospitals here have a clinical research wing now. That is really good. If the doctors add deep genuine research based knowledge to their learned or observed superficial knowledge in hospitals or educational institutes, they can treat the patients in a better way.
Q: What don't you understand but find so fascinating?
Krishna: The full working of this universe based on science. We have yet to unravel several scientific mysteries. Venturing into that unknown world is so fascinating.
Q: Can we get rid of ghost sightings when we visit doctor and get medicines for mental conditions?
Krishna: Recently a person told me his own experience. When he was six, it seems, he started seeing black faces outside his bedroom window. He used to scream with fear. But his siblings never saw them. He was taken to a hypnotist but his condition worsened. He was taken to a witch doctor, but she too couldn't bring any relief.
Then finally he was taken to a hospital. He was diagnosed with a brain tumour! He got operated, took medicines. Since then he became normal.
Q: When all of science is provisional, how can you accept that they are scientific facts?
Krishna: Isaac Asimov's book of essays 'The Relativity of Wrong' explains it clearly.
Wronger than wrong: When people thought earlier (now also some people think it is still flat!) the Earth was flat, they were wrong. When people thought the Earth was spherical, they were wrong. But if you think that thinking the Earth is spherical is just as wrong as thinking the Earth is flat, then your view is wronger than both of them put together.
Asimov explains that science is both progressive and cumulative. Even though scientific theories are later proven wrong, the degree of their wrongness attenuates with time as they are modified in response to the mistakes of the past. For example, data collected from satellite measurements show, to a high level of precision, how the Earth's shape differs from a perfect sphere.
The oblate spheroid (a sphere that is squashed at its poles and swollen at the equator), or oblate ellipsoid, is an ellipsoid of revolution obtained by rotating an ellipse about its shorter axis. It is the regular geometric shape that most nearly approximates the shape of the Earth.
Therefore, being wronger than wrong is actually worse than being not even wrong (that is, being unfalsifiable).
Earth is not flat. Saying that it is flat is completely wrong. We have evidence for that.
Later Earth was thought to be completely spherical.
Finally Earth was found to be an oblate spheroid (a sphere-like but not perfectly spherical body). Now which was is more closer to truth? A flat Earth or a sphere? A sphere. Therefore thinking that it 's flat is not equal to thinking that it 's a sphere.
Both are wrong but flat is absolute wrong and sphere is relatively wrong. There lies the difference.
Scientific facts are like that now. The search for something better must continue. Although provisional, scientific facts are getting closer to truth now than earlier times. Therefore, if you say, 'theories are always preliminary and science really doesn't 'know' anything' is not actually correct. Science is relatively correct now ... until someone falsifies it, it has to be accepted as the best knowledge we have now on any topic.
Q: Can science find and tell the world true facts when various governments around the world trying to control it?
Krishna: Genuine science needs total freedom. Any outside control is detrimental to its existence. However, science, the thing this universe is made of, is an eternal fact. No power can take away that fact. People can only control our understanding of it, not the science this universe is made of. We get comfort from the thought.
Only the world is getting fooled with tight controls. We are loosing our benefits.
But the universe still goes on based on science. It doesn't make any difference whether you find the facts or not to the universe and science that runs it.
Q: Does eating sugar cause diabetes?
Krishna: Sugar processing in a living body is a complex process. Briefly, Insulin is a hormone that — in people without diabetes — ferries glucose, or blood sugar, to cells for energy or to be stored for later use. In people with type II diabetes, cells are resistant to insulin; as a result of this insulin resistance, sugar accumulates in the blood. While eating sugar by itself does not cause insulin resistance, foods with sugar and fat can contribute to weight gain, thereby reducing insulin sensitivity in the body.
Moreover, when a person becomes fat as a result of eating lots of sugary substances, there won't be enough insulin in the fatter body to go around.
Therefore, you can say sugar indirectly is the reason for diabetes.
Q: Can real Draculas exist according to science?
Krishna: Some people suffer from certain mental conditions which make them kill and drink people or animal blood. These things have been reported in the media. Then some people perform some sort of rituals in which they sacrifice living beings and drink their blood or use it in other ways like smearing it all over their bodies.
In earlier times, it was reported - though these things cannot be verified now - some people killed and drank the blood of their enemies. It seems, some old men too did this believing that killing young men and drinking their blood can give them youthful vitality. Some epileptic patients used to drink blood to 'cure their condition' because of a false belief. These beliefs were mainly associated with some cults and religions around the world. Some vampires 're looking for psychic energy that gives them strength, others believe their need for blood is purely physiological. Others think it is psychological. Medical fraternity agrees with the latter explanation. It mostly works like a placebo.
Yes, some normal people too drink blood. Some of these people say the oxygen- and iron-enriched substance gives them energy, if taken in limited quantities. These people claim to suffer from a strange medical condition – fatigue, headaches, and excruciating stomach pain – which, they believe, can only be treated by feeding on another human's blood.
However, because blood is so rich in iron — and because the body has difficulty excreting excess iron — any animal or person that consumes blood regularly runs a risk of iron overdose. While iron is necessary for all animals - and indeed most life, in high doses it can be toxic. This condition, called haemochromatosis, can cause a wide variety of diseases and problems, including liver damage, buildup of fluid in the lungs, dehydration, low blood pressure, and nervous disorders.
The bodies of animals that digest blood, like the vampire bats, have adapted specialized digestive mechanisms. They have special process for secreting the excess. Research on this process suggests that bats have a mucous membrane along the intestinal tract that acts as a barrier to prevent too much iron from getting into their bloodstreams. Because humans did not evolve such an iron-extracting mechanism, drinking a large quantity of blood can kill us.
If the vampires can come out into the open and co-operate with the scientists, they can really find out why some people are blood thirsty and find a cure for it.
Q: I understand you don't believe in souls. But, please could you explain xenoglossy and near death experiences - both of which scientists have been trying to understand for years without coming to any satisfactory conclusion?
Xenoglossy is the ability to speak a language without having learned it. How can anybody do it?There is no scientific evidence that xenoglossy is an actual phenomenon. People who make such claims are frauds. The satisfactory conclusion science arrived at is … there is absolutely no evidence. When there is no evidence, it is a rubbish claim. Period.
Q:How do people justify the alternative medicine industry not researching their products scientifically when they're a multi billion dollar industry?
Krishna: Multi-billion dollar industries need not be based on genuine scientific evidence. They can be even based on pseudo-science, peoples' belief, dubious research published in fake journals, placebo effect, misconceptions and several other things. As long as suckers exist and people willing to fall into traps, desperate to have a solution - even if it is a fake one, anybody can fool people like these.
Why do you think people fall for fake Godmen, advertisements that make astonishing claims, spurious medicines and alcohol that kill them?
Same logic can be applied here.
When you can bribe the Government officials, hoodwink them to accept your proposals, power to go ahead despite the drawbacks, who can stop you from establishing a multi-billion dollar alternative medicine industry?
Homeopathy is one good example.
Cry, world, cry. If you willingly refuse to listen to genuine evidence based facts, suffer. Who are we to say anything against it?
But still we are trying our best to educate people wondering when the world will come to its senses.


text:
Art Project to Beam Neil Armstrong's Heartbeat, Footprint Back to the Moon
By Sarah Lewin published 25 September 15
A new art project by Richard Clar will bounce images and sounds representing the moon landing off of the moon, capturing the radio waves with this satellite at the Dwingeloo Radio Observatory in the Netherlands. (Image credit: ASTRON, the Netherlands Institute for Radio Astronomy)
Just in time for this Sunday's (Sept. 27) lunar eclipse, artist Richard Clar will execute two moon-inspired projects that will send a part of Neil Armstrong back to the moon and create an introduction between the "light side" and "dark side" of the lunar surface.
Clar's two-part event will bounce some very special radio waves off of the moon from a radio dish in Italy and retrieve them at Dwingeloo Radio Observatory in the Netherlands. The first transmission is encoded with a version of Armstrong's heart activity that was recorded as he became the first person to set foot on the moon, as well as an image of Armstrong's moon footprint. A second signal will carry an image of the moon's dark side, which only the Apollo astronauts have seen in person.
The transmissions, called "Giant Step" and "Lune sur la Lune" ("Moon on the Moon"), will be made on Sept. 27 at 9 a.m. EDT (1300 GMT) and 11 a.m. EDT (1500 GMT), respectively, and will soon after appear online at www.rockthemoon.com.
For the project, Clar took a copy of Armstrong's electrocardiogram (EKG) — a record of his heart's electrical activity — captured as the astronaut stepped onto the surface of the moon for the first time. Clar turned the EKG into sound with the help of data scientist Ryan Compton. Then, jazz performer Roberto Miranda used the EKG as inspiration for a series of sounds on the double-bass. That recording will fly on Saturday along with the iconic images, also in the form of radio waves. The "dark side" image will bounce off the moon's "light side," which is always facing Earth.
First footprint on the moon left by Neil Armstrong. (Image credit: NASA)
"I wanted the art to say something about the first humans to set foot on the moon. Think how many living beings have observed the moon for eons … and now we have made a number of trips to the moon and back. I want people to have new experiences through my artwork," Clar said in a statement.
This project is inspired by artist Daniela de Paulis' work bouncing images off of the moon, which she first did in 2009. (One of her projects worked with NASA to beam moon-inspired children's artwork off of the lunar surface.) This is far from Clar's first stab at space art: His projects have used new technology to explore orbital debris, the search for extraterrestrial life and other out-of-this-world themes.
Email Sarah Lewin at slewin@space.com or follow her @SarahExplains. Follow us @Spacedotcom, Facebook and Google+. Original article on Space.com.
Sarah Lewin
Sarah Lewin started writing for Space.com in June of 2015 as a Staff Writer and became Associate Editor in 2019 . Her work has been featured by Scientific American, IEEE Spectrum, Quanta Magazine, Wired, The Scientist, Science Friday and WGBH's Inside NOVA. Sarah has an MA from NYU's Science, Health and Environmental Reporting Program and an AB in mathematics from Brown University. When not writing, reading or thinking about space, Sarah enjoys musical theatre and mathematical papercraft. She is currently Assistant News Editor at Scientific American. You can follow her on Twitter @SarahExplains.
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redpajama_set_name: RedPajamaCommonCrawl


text:
#pragma once
#include <aws/eks/EKS_EXPORTS.h>
#include <aws/eks/EKSRequest.h>
#include <aws/core/utils/memory/stl/AWSString.h>
#include <aws/eks/model/IdentityProviderConfig.h>
#include <utility>

namespace Aws
{
namespace EKS
{
namespace Model
{

  /**
   */
  class AWS_EKS_API DescribeIdentityProviderConfigRequest : public EKSRequest
  {
  public:
    DescribeIdentityProviderConfigRequest();

    // Service request name is the Operation name which will send this request out,
    // each operation should has unique request name, so that we can get operation's name from this request.
    // Note: this is not true for response, multiple operations may have the same response name,
    // so we can not get operation's name from response.
    inline virtual const char* GetServiceRequestName() const override { return "DescribeIdentityProviderConfig"; }

    Aws::String SerializePayload() const override;

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline const Aws::String& GetClusterName() const{ return m_clusterName; }

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline bool ClusterNameHasBeenSet() const { return m_clusterNameHasBeenSet; }

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline void SetClusterName(const Aws::String& value) { m_clusterNameHasBeenSet = true; m_clusterName = value; }

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline void SetClusterName(Aws::String&& value) { m_clusterNameHasBeenSet = true; m_clusterName = std::move(value); }

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline void SetClusterName(const char* value) { m_clusterNameHasBeenSet = true; m_clusterName.assign(value); }

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline DescribeIdentityProviderConfigRequest& WithClusterName(const Aws::String& value) { SetClusterName(value); return *this;}

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline DescribeIdentityProviderConfigRequest& WithClusterName(Aws::String&& value) { SetClusterName(std::move(value)); return *this;}

    /**
     *
The cluster name that the identity provider configuration is associated
     * to.

     */
    inline DescribeIdentityProviderConfigRequest& WithClusterName(const char* value) { SetClusterName(value); return *this;}

    /**
     *
An object representing an identity provider configuration.

     */
    inline const IdentityProviderConfig& GetIdentityProviderConfig() const{ return m_identityProviderConfig; }

    /**
     *
An object representing an identity provider configuration.

     */
    inline bool IdentityProviderConfigHasBeenSet() const { return m_identityProviderConfigHasBeenSet; }

    /**
     *
An object representing an identity provider configuration.

     */
    inline void SetIdentityProviderConfig(const IdentityProviderConfig& value) { m_identityProviderConfigHasBeenSet = true; m_identityProviderConfig = value; }

    /**
     *
An object representing an identity provider configuration.

     */
    inline void SetIdentityProviderConfig(IdentityProviderConfig&& value) { m_identityProviderConfigHasBeenSet = true; m_identityProviderConfig = std::move(value); }

    /**
     *
An object representing an identity provider configuration.

     */
    inline DescribeIdentityProviderConfigRequest& WithIdentityProviderConfig(const IdentityProviderConfig& value) { SetIdentityProviderConfig(value); return *this;}

    /**
     *
An object representing an identity provider configuration.

     */
    inline DescribeIdentityProviderConfigRequest& WithIdentityProviderConfig(IdentityProviderConfig&& value) { SetIdentityProviderConfig(std::move(value)); return *this;}

  private:

    Aws::String m_clusterName;
    bool m_clusterNameHasBeenSet = false;

    IdentityProviderConfig m_identityProviderConfig;
    bool m_identityProviderConfigHasBeenSet = false;
  };

} // namespace Model
} // namespace EKS
} // namespace Aws

redpajama_set_name: RedPajamaGithub


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text:
Cystic Echinococcosis of the Pelvic Bone with Recurrences: A Case Report
Sunila Jain, Prem Chopra
Jain and Chopra: Cystic Echinococcosis of the Pelvic Bone with Recurrences: A Case Report
Published online: September 30, 2011
Sunila Jain1, Prem Chopra1
1Pathology Department, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, Delhi 110060, India.
Corresponding author (S_Isha19@rediffmail.com)
Received July 19, 2011 Revised August 10, 2011 Accepted August 10, 2011
© 2011, Korean Society for Parasitology
(open-access, http://creativecommons.org/licenses/by-nc/3.0):
Hydatid cysts commonly affect the liver and the lung. However, they rarely involve bones with vertebral column. We hereby report a case of a female patient with cystic echinococcosis of the hip bone and ilium. She presented with a long history of frequent recurrences highlighting the dismal prognosis at this rare site. Resection of the hydatid cyst from the sacroiliac region was done with allograft and autograft (rib graft) with lumbosacroiliac fixation. Follow-up of the patient at 6 months showed no detectable abnormality on radiology and the patient was doing well.
Key words: Echinococcus granulosus, pelvic bone, hydatid, case report, India
Cystic echinococcosis of the bone is rare with an incidence of 0.5 to 2.5% [1], and as compared to other sites, osseous hydatidosis presents late, as it is usually not suspected clinically because of its rare occurrence at this site. Bone hydatidosis is difficult to treat and carries high morbidity due to frequent recurrences, especially in certain locations, like ilium and hip, where radical surgery is difficult. We herein report a case of cystic echinococcosis of the hip bone and pelvis for its uncommon site and frequent recurrences depicting a poor prognosis and high morbidity at this site. Only a few case reports of long term follow-up of such cases are available in literature.
A 31-year-old Asian Indian female presented to the outpatient department of Sir Ganga Ram Hospital, New Delhi, India with a history of increasing pain in the right hip and pelvis for the last 3 years. Pain was progressively increasing in intensity, radiating to the right lower limb and back, increased on movements and associated with tingling sensation since last 3 months.
The patient had become quite incapacitated due to painful restricted movements. Her past history showed that at 22 years of age, she had presented with a large abdominal mass. Her CT at that time showed a multicystic lesion measuring 18.0×9.8×7.6 cm in the right abdomen, which appeared to be arising from the right ovary. The liver and other organs, including the uterus, kidneys, and left ovary, were normal. Her lung x-ray at that time was normal. Thus, with a clinical diagnosis of a right ovarian tumour, she underwent surgery which showed a hydatid cyst which was confirmed on histopathology. Peroperatively her ovaries were normal with presence of paraovarian cystic masses which were densely adherent to the right ovary.
After remaining asymptomatic for 3 years, in 2007, she again gradually developed pain in the right pelvic region. This time MRI showed a large solid cystic mass measuring 10×6.3 cm in the right iliac fossa and right gluteal region. It was arising from the right iliac bone, involving right sacroiliac joint and adjacent marrow of the sacrum. All other pelvic organs were unremarkable. With a clinical possibility of tumour or tuberculosis, a diagnostic laparatomy was planned. Peroperatively, multiple cysts in the iliac bone with osteolysis were seen. Two cystic pieces were removed which were diagnosed as hydatid cyst. In view of the complicated nature of cysts and location it could not be completely excised.
The patient continued with the pelvic pain although postoperative MRI showed reduction in size of the lesion along the right iliac bone and sacroiliac joint. No new lesion was, however, seen. The x-ray of the pelvis and hips revealed cortical irregularity with ill defined lytic defects and linear areas of patchy sclerosis along the right iliac blade (Fig. 1). She continued with pain and follow-up CT reviewed after 8 months revealed extension of the disease. The patient was then referred to our hospital. On physical examination, local tenderness was present on the back of the right limb and hip. The range of motion of the right hip was painful and restricted. No distal neurovascular deficits were present. Blood investigations were within normal range. Surgery was planned for removal of the residual disease. The preoperative MRI and CT showed progression of the disease. The CT showed a multiloculated cystic lesion (Fig. 2) involving the medullary cavity of the right iliac bone resulting in irregular lytic destruction and extending across the right sacroiliac joint into the right half of the sacrum, right sacral foramina, and adjacent soft tissues. Resection of the hydatid cyst of sacroiliac region with allograft and autograft (rib graft) with lumbosacroiliac fixation was done.
Histopathology results revealed hydatid cysts of the bone. Fragments of the osseous tissue with hyaline and laminated membranes of hydatid cysts were seen admixed with lymphocytes and monocytes (Fig. 3). Focal areas of necrosis, calcification, palisading histiocytes, and numerous foreign body granulomas were observed in the intertrabecular spaces. The serological and molecular identification of the parasite, however, could not be performed due to non-availability of the facility in the hospital. She was also put on a medical treatment with albendazole for 1 month. The postoperative period was uneventful and patient was discharged on the 10th day of surgery. The follow-up of the patient at 6 months showed no detectable abnormality on radiology, and she was doing well.
Cystic echinococcosis is caused by a parasitic tapeworm, echinococcus. In humans, 3 forms of echinococcosis are known to occur; cystic echinococcosis (CE), caused by Echinococcus granulosus, alveolar echinococcosis (AE), caused by Echinococcus multilocularis, and polycystic echinococcosis (PE), due to Echinococcus vogeli or Echinococcus oligarthrus. The liver and lung involvement together account for at least 90% of the cysts. Other organs, which may rarely be infected, are the kidney, spleen, muscles and skin, and bones [2].
Bone involvement of echinococcosis rarely occurs. Common reported sites of bone involvement were the vertebra, femur, and pelvis [3,4]. Occasional cases have been reported in the rib and humerus.The disease in the bone starts when scolices settle there. Skeletal cystic echinoccocosis lesions may be single or multiple. Most of the patients become symptomatic at an advanced stage with symptoms of pain and tenderness at the affected site and rarely with fracture. The disease slowly destroys the bone with trabecular resorption.
Bone hydatidosis is usually diagnosed by roentogenographic studies [5]. MRI is the most helpful of all the imaging modalities and should be done to evaluate the extent of the disease and planning of the treatment [5]. Immunological studies are not much helpful. At times, however, radiology may mimic a variety of benign and malignant lesions of the bone. In all these cases, histopathology gives the correct diagnosis. The principal treatment of cystic echinococcosis of the bone is surgery with wide excision followed by mebendazole therapy. Chemotherapy is more useful for inoperable cases.
Bone hydatidosis commonly present with recurrences as was seen in the present case leading to high morbidity. The results of treatment of osseous hydatidosis are satisfactory only in locations where complete and wide excision is possible. In the pelvis and hip, where radical surgery is almost impossible, the results are disappointing even after aggressive treatments, hence, they present with frequent recurrences [6,7] and a long term follow-up is therefore recommended.
The purpose of this study is to be aware of this disease at this rare location. This will help early diagnosis and planning of the treatment. It also highlights that a more aggressive treatment is needed to minimize recurrences in bone involvement by cystic echinococcosis and a long-term follow-up of these patients needs to be done.
1. Sapkas GS, Stathakopoulos DP, Babis GC, Tsarouchas JK. Hydatid disease of bones and joints. 8 cases followed for 4-16 years. Acta Orthop Scand 1998;69: 89-94. PMID: 9524526.
2. World health Organization. In Eckert J, et al ed, WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. 2001.
3. Siwach R, Singh R, Kadian VK, Singh Z, Jain M, Madan H, Singh S. Extensive hydatidosis of the femur and pelvis with pathological fracture: A case report. Int J Infect Dis 2009;13: e480-e482. PMID: 19342261.
4. Stavrev VP, Poryazova EG, Chonova EV. A case of pelvic bone hydatidosis-diagnosis and treatment. Folia Med (Plovdiv) 2006;48: 60-63. PMID: 16918057.
5. Edeiken J, Dalinka M, Karasick D. Edeiken, Roentgen Diagnosis of Disease of Bone. 1990, Vol. 1: 4th ed. Baltimore, Maryland, USA. William and Wilkins.
6. Herrera A, Martínez AA. Extraspinal bone hydatidosis. J Bone Joint Surg Am 2003;85-A(9):1790-1794. PMID: 12954839.
7. Massè A, Parola PG, Brach del Prever EM, Gallinaro P. Hydatidosis of the pelvis: A case report with a 25-year follow-up. Arch Orthop Trauma Surg 2004;124: 203-205. PMID: 14770319.
X-ray of pelvis and hips revealed ill-defined lytic defects and linear areas of patchy sclerosis along the right iliac blade (arrows).
CT revealed a multiloculated cystic SOL involving the medullary cavity of the right iliac bone and causing irregular lytic destruction extending into the right SI joint, right half of the sacrum, and right sacral foramina.
Hydatid cyst wall fragments (C) interspersed within the bone (B) (H-E, ×400).
Sparganosis of the Unilateral Breast: A Case Report 2017 August;55(4)


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Hypercaffium Spazzinate
Epitaph Records
There's nothing like the news of a new Descendents album to improve a summer in advance –and, with a particularly slow start to the good weather, their short, sweet blasts of melodic punk are exactly what is needed to counteract the strangely unseasonal Seasonal Affective Disorder caused by leaving the house at least three days a week to find South London rain-drenched and storm-swept.
Hypercaffium Spazzinate, of course, would be a cause for celebration regardless of the weather; the band's first release since 2004 sees them return to Epitaph, the label under which they recorded 1996's 'Everything Sucks'. Does this mean we can draw in depth stylistic comparisons between the two albums recorded under Brett Gurewitz's label whilst at the same time contrasting them with 'Cool To Be You', the Fat Wreck album sandwiched between? Does it bollocks. Bill Stevenson has always had a keen eye to which side his punk rock bread is buttered on and Hypercaffium sits comfortably amongst the band's previous efforts, offering 16 sometimes deceptively sharp blasts of what can be termed 'pop punk', but only once you mentally eschew the taint of saccharine awfulness which the late 90s and early 00s bought to that term.
Opener 'Feel This' sets the general pace at 1:14 in length, with only half the songs exceeding two minutes and a grand total of three that get past three. I found myself having to stop the album when I needed to go down and get a beer out of the fridge, in case I missed anything vital. That's what you get with me, quality professionalism. Anyway, 'Feel This' drives full speed into 'Victim Of Me', the song which pre-hyped the album to the world and while it may not quite reach 'Milo Goes to College' speed, it definitely offers Karl Alvarez's fingers a workout on a breakneck bass line on a tune which will have you skipping the needle back more than once (or moving the mouse and double clicking like the horrible nowadays bastard you are). 'On Paper' slows things down and brings into the mix the self-deprecating humour that Milo's soulful, very slightly snotty, very slightly roughened voice is so perfectly suited to – the sound that so many vocalists took as a template to fall far short of.
From then on in and for 16 songs the band take the sound which they've perfected so well and throw in a number of variables, still keeping hold of their core formula like a control variable in one of Milo's lab tests. 'No Fat Burger' harks back to the band's earliest days musically, as Bill Stevenson's lyrics bemoan the doctor's orders which have stopped him scoffing whatever he wants due to health issues covered in the killer 2013 documentary 'Filmage'. Just remember as you listen to the primal but supremely controlled beat underpinning every track that the man playing it has survived health issues which would kill five other people at once.
Elsewhere, this may not be a change in style from previous releases but that doesn't mean that the Descendents are ploughing the same furrow in any way. On the contrary. The hooks which made the likes of 'Bikeage', 'Silly Girl' and 'When I Get Old' such instant classics do the same for much of Hypercaffium. Whether it's the full pelt race of 'Human Being' or the mellower, hook laden likes of 'Shameless Halo' or 'Comeback Kid', the band sound like they don't even know what the term 'twelve year album gap' means. Closer 'Beyond the Music' is a potted history of the band, a microcosm of the personal lean of their lyrics which has definitely played a massive part in them becoming such a worldwide phenomenon.
Despite having almost 40 years of history, and a major place in the history of punk music and numerous musical milestones, they are still writing songs of awkward love, caffeine obsessions and flatulence which strike a chord the world over…and long may they continue doing so.
Jono Coote
Tags album, album review, bill, descendents, epitaph records, free download, hardcore, Hypercaffium Spazzinate, milo, punk
Features Music
Wand interview
March's sophomore album release Golem saw Los Angeles-based Wand state their claim as a face-slapping psychedelic force to be reckoned with, inviting you on a juvenile joyride to bold, head-melting dimensions unknown across nine treacherous tracks.
Fast-forward six months and Wand are still skidding through the grimy back-streets of sludge rock and doom with gusto, yet this time around there's even more on offer. To investigate the trio's new-found Crazy Horse-indebted groove, we sent Yasmyn Charles down to Brighton to catch up frontman Cory Hanson and find out how, exactly, their new album 1000 Days became reality.
What was the formative process of Wand and how did it come into being?
Well, the three of us went to art school together and after we all graduated we all had a bunch of different projects and I just kind of asked everyone if they wanted to play music together… so we did. It's a pretty unremarkable story! [Laughing]
Did you have any idea of the sound direction you wanted to take?
I was listening to a lot of 70's German, kind of krauty music at the time and I'd been playing in a lot of Rock n Roll bands and then decided I wanted to start a more 'arty' rock-driven project I guess.
Do you feel you've kind of achieved that with Wand?
Yeah, I mean it was maybe a good choice because there are a lot of musical directions you can take at any given time. So it makes it easier to be inspired than maybe working within a more succinct genre of music that's more defined by the traditions it's partaking in.
Would you say that residing in LA has had a positive influence on your sound due its current and past musical history or has it had no effect at all?
Well I'm from LA and I've never lived anywhere else so I think it has had a huge effect on me in terms of growing up there and sort of seeing the way things have changed. LA's an interesting city because it has these really intense moments of scene proliferation, it's an explosion of bands then it will kind of eat itself and then it has to start over from scratch. Then there'll be moments where LA seems so attractive then huge lulls where it's a very unattractive place to be and everybody hates it. And right now for some reason there's like a really big light shining on the place that I've lived forever and everyone is transplanting themselves into the city and it's kind of bizarre to me.
Golem sounded far more acerbic and abrasive than Ganglion Reef and this was supposedly down to a shift in songwriting away from you to greater inclusion of the rest of the band. Has this been the same for 1000 Days?
I feel like our process is constantly evolving because we're always trying new ideas and configurations of writing songs. With 1000 days, it was within the sort of framework for which we wanted to make the album in terms of it being a lot larger and more about having the space to make mistakes and experiment with things. Both Golem and 1000 days are very performance intensive. We spent a lot of time in a rehearsal space for like hours and hours and hours just reconfiguring songs, breaking them apart and trying to find every possible outcome that we could. The only rule that we had for 1000 days was that every single part of the process for writing a song, the song had to change dramatically. It had to be altered from one moment to the next; it could never be played the same way twice.
Is this something you recreate live as well?
Yeah, we try. I mean it's interesting because we don't really like to play the songs the way they are on our records. For us the records are these things we spent a lot of time making and in order to stay true to the writing process and the kind of spirit of the songs, they have to change within the structure of a performance. It's a very different space than a recording space.
You've said that Golem was recorded at "not an upbeat time". Has the atmosphere affected the output on 1000 Days the way it did with Golem?
We've gone through a lot of changes as a band. And personally through a lot of highs and lows in our short career that have totally influenced the way that the records are shaped and the kind of themes that get brought into the songwriting and the recordings and the way that we treat the recordings. We definitely have no intentions of making a happy record or a sad record but rather something that's a little more true to the time we spend in the band and out of the band.
There's definitely a sense of that on the albums. There's no emotional guidance, you form your own emotive ideas about the music.
Yeah, I mean, we don't really have a compass for those kinds of things or a trajectory… in most ways [Laughs].
It's been said that the influences for your past material have been Final Fantasy and Dungeons and Dragons, what have been the influences for 1000 Days?
Hmmn. Let's see… We were listening to a lot of Crass and a lot of Psychic TV and Throbbing Gristle. A lot more Industrial and Anarcho-Punk bands.
There's maybe a slightly more electronic slant on 1000 Days, is that something bore of listening to these industrial acts?
Yeah, we all have a previous relationship to these kinds of bands but the influences seemed to take on more of a character during the recording of 1000 Days. I mean we've had synthesizers on every record and on every record we process all of the guitars through a lot of synths. They're very much studio records in the sense that everything is being massaged and processed and treated in a certain way. So it's sort of an accumulation of experiences in the studio that resulted in the records sound.
So you've followed a very natural process with the recording sound but also appear to have a deliberate 'mystical' aesthetic both visually and as part of your sound. Is this intentional?
Yeah, I mean there is a curiosity/relationship to fantasy or esoteric themes but I feel that a lot of the space that's occupied is not that. Like, if that's the kind of outer… 'trappings' of the music, then the things going on inside are pretty real. [Laughs] In the sense of us being human beings it's kind of inescapable that we're going to have a relationship to the music that's really intense.
Do you think that that's essentially the nature of psychedelic music in the sense that's it's something both real and a form of escapism?
Well…I wouldn't say the music's escapist, though it may flirt with those ideas, I think that in the most positive sense, escapism is a way of finding a moment of removal from the present or whatever surface problems that are accumulating in order to better understand what's happening. It's so that you can re-interpolate into reality or the present and become better equipped to deal with shit.
If you had to describe 1000 Days in one sentence, what would it be?
[There's a long silence] I don't know… I feel that the title is pretty indicative of what's on the record. To me it feels massively contained. It's a lot of information and a lot of music that's selected and curated in way that despite it being the shortest record we've made, it feels like the biggest. And it is, for us, our biggest… kind of…
Magnum Opus?
Not our magnum opus but up to this point the truest that we feel about music and about playing and making records. It's just a more ambitious version of what we have been doing.
Even though that wasn't a sentence it was still a pretty good answer! Has there been any anxiety with trying to follow up the success of Golem.
I have a lot of anxiety about those things! We basically started writing 1000 Days as soon as Golem was mixed and mastered and the artwork was at the plant. We were like, let's make another record before this one comes out and we did it with the last one too. The real hurdle we're going to have to overcome at some point is that, now we have these records and the stuff that's been happening, we need a little time to process all of this in order to make the next one.
Would you say that all your past projects have taken a complete backseat along with your solo work?
With Pangea I haven't been in that band for 3 years and Meatbodies 2. As for all of my other projects, they're now just kind of happening in the leftover space… there's no real point of even talking about them because they're in the spectrum of ideas that are maybe materialising in some way or another.
So Wand's your main output for material you're truly happy with?
Yeah, at this point. I'd love to be happy with some other projects really soon, and hopefully that'll be the case. But for now Wand is the main vehicle for my songwriting at least.
What's next for Wand?
After this tour the record comes out then we have a US tour. Then after that we'll start recording and writing again. We've established this sort of cycle of touring and recording.
There appears to be this idea of 'if a shark stops swimming it dies' – where you always have to be creating?
Yeah we don't feel very comfortable taking time off because we're not in a position where we're making enough money to! [Laughs]. We're still kind of struggling to make a living as musicians and artists and so there is a sense of urgency. It's also important for us not to get ensnared in the kind of cycle that most bands get trapped in. Where you make a record…it takes 6-8 months to comes out… then you tour the record for half the year then it takes a year and a half to produce another record. We're definitely not interested in that kind of structure, and we can't do that because we have to keep making records.
Support Wand in their mission to keep playing and making music by ordering their new album on Drag City out on September 25th from here or order it from your local record shop. It's a damn good one, you will not be disappointed.
Promo photos: Romain Peutat
Words and instant camera shots: Yasmyn Charles
Tags 1000 days, album, band, download, free, ganglion reef, golem, hardcore, interview, la, london, music, psych, punk, wand, wand band
Chronicles with Gengahr
Post author By Dave
"I'm pretty sure the label were ready to drop us when we told them the fourth time that it still wasn't right and we'd have to give it another going over," reveals Felix Bushe, guitarist and main man of London's Gengahr, as he racks his brains over the trials and tribulations of their decision to co-produce their fast approaching debut, A Dream Outside.
Heralded as the finest purveyors of hazy, psychedelic pop right now, Gengahr have risen fast and high above their contemporaries, with tracks like 'Fill My Gums With Blood', 'Powder' and 'She's A Witch' raining from the stereo in here on loop.
When asked about the band's most personal lyric on the album, before we dive into his own musical psyche below, Felix cites 'Lonely As A Shark's verse of, "All I ask is just one more chance. If I grew horns and fins, at least I'd get to start again. And speak in tongues just like it all began. Somewhere underneath the sea are teeth the size of you and me."
Going on to explain, "I normally try to disguise myself in the songs with fictional narrative but 'Lonely As A Shark' in particular is a song full of my own emotions. I wrote this at a time when I had moved to the suburbs of London and rarely saw any of my friends. I was working full time and I had tried to go back to university because I felt my life lacked direction. The song is basically about my isolation and solitude at that time."
Check out Felix's nine most personal albums below, but first hear their eerie new cover rendition of Fugazi's 'I'm So Tired'. Not many have managed to pull off covering one of the finest band's in history.
My gateway album is…
The Argument – Fugazi
Whenever you put on a Fugazi record it just makes you feel cool, and that's a big part of being at college and school.
The album my fans might not expect me to like is…
Mechanical Animals – Marylin Manson
I love this album, I swapped it for a Slipknot album with a friend at school and even now if I put it on it still sounds great. Some dope tunes on this one.
When I'm angry at the world, this album fires me up!
Around The Fur – Deftones
If it wasn't Fugazi then I was probably listening to Deftones as the backing music to my school days.
A record I absolutely despise is…
Any album by Ed Sheeran.
He has no soul!
An album for Sunday chilling is…
Halcyon Digest – Deerhunter
These guys are maybe my favorite band and I could have named any of their albums really but this is one I've been listening to most recently.
An album to dance your ass off to is…
Hello Nasty – Beastie Boys
These guys bridge the gap between rock, hip hop and dance so effortlessly. I was blown away by the Beastie Boys during the whole MTV2 years.
The album I'd like to see live, in its entirety, back to back is…
3 Feet High and Rising – De La Soul
I feel like I don't get to see enough Hip Hop music when we are playing festivals or whatever but this album would be amazing to see in it's entirety.
The album that evokes a specific memory is…
Devotion – Beach House
This record reminds me of my first flat after moving out from mum and dad. My flat mate used to play it all the time and its a really beautiful record.
If the world was ending, the last album I'd want to hear is…
Transformer – Lou Reed
One of my all time favourite albums. Featuring two of my all time favourite guys, Lou Reed and David Bowie. This is maybe the closet thing to a perfect record in my eyes so it's fitting that it would be the last thing I ever hear.
Gengahr's 'A Dream Outside' is due June 15th via Transgressive.
Tags A Dream Outside, album, bon voyage cliche free download, download, felix bushe, free download, Gengahr, gengar, gengarh, interview, transgressive
Poison Idea live at the Borderline, London
Poison Idea
The Borderline, London
May 7th
Poison Idea have history right in the centre of London. All of their 90s appearances in the capital exploded in the centre; from that first incendiary performance with the Hard Ons at ULU in '91, to the legendary Marquee and Astoria gigs, tonight Poison Idea returned to hit the centre dead-on again at The Borderline. With pretty much all of the rock n' roll now flattened and demolished in Central London, the heart ripped out of it, it's fitting to have Jerry A and his kings of punk return to the ruins and re-charge it once again with their vital metallically-charged hardcore punk.
As we climb down the stairs into the pit of punks crammed in to The Borderline, the first thing that hits you is the stench of puke and sweat, the deathly aroma of punk. The room is buzzing (and gagging on the smell) with anticipation for the return of Portland's legendary Poison Idea who are very much back. Their new album 'Confuse & Conquer' is the best they've recorded since 1992's 'Blank Blackout Vacant' and Jerry finally has a line-up that is committed, settled and does the music justice. Currently three-quarters through the longest and most gruelling tour they've done in many years, Jerry's punished voice may be raw and ripped but from the moment the band hit the stage, they are bone-tight and packed full of power. With '87 era-guitarist Eric 'The Vegetable' Olsen back in the band and stick-thin drummer Nathan Richardson pounding the skins with more power than his appearance might suggest, Poison Idea kill it tonight.
Yes, it takes a few songs for Jerry's voice to settle in but once it does, it's as snarled and powerful as it ever was. "This one's for Nigel Farage," he says as the band steam into 'Discontent' ("listen Nazi, never again,") and the entire room detonates into a flurry of limbs and sweat. And the hits just keep on coming. They play pretty much every essential song you could want to hear – 'Just To Get Away', 'Getting The Fear', 'Punish Me', 'Taken By Surprise' and 'Give It Up' , all of which square up well with the sprinkling of new 'Confuse & Conquer' tracks the band play tonight.
At the end a woman's boot is thrown onstage. Jerry picks it up, empties half a bottle of cider into the bottom of it and swills the contents into his mouth. "Tastes like a size 6," his says before the band wind the set up with a double stab of Johnny Thunders and Avengers covers. A perfect punk rock night. We're so fucking glad Poison Idea are still here.
James Sherry
Tags album, band, Blank Blackout Vacant, borderline club, Confuse & Conquer, Gig, jerry A, kings of punk, london, new album, POISON IDEA, punk, review, tour
Album Reviews Buzz Chart
Doctor and the Crippens
Raphanadosis
Boss Tuneage
There are certain albums from the 80s that bring back so many incredible memories that you just have to re-buy them – Raphanadosis is definitely one those. From the grinding blast beats of 'Garden Centre Murders' to the zombie intro of 'Braindead', (still one of the best intro's to a hardcore record of all time) this 22-track masterpiece full of nightmares comes packed with super-fast, quintessentially British hardcore with humorous subject matter that will be an anthem for many.
The gritty, monstrous vocals of 'My Brother Is A Headcase' still sounds like a vegetarian is tied up in a basement being force-fed bacon whilst listening to 'Henenlotter' on repeat. The eerie build up in 'Button Moon' still retains a creepy cesspit of misery before you are blown into outer space.'The Kid With The Removable Face' is still being used as a frisbee (and still making me LOL) and '8 Years in Office' and 'Extreme Noise T' are still the best shortest songs on the album. More records should also have titles for the A and B sides too. Side 'Insecticide' was always followed by Side 'Fungicide' with this release, you could never just listen to half of it. Brilliant stuff.
I feel like 'Wurzel Gummidge on acid' listening to this again, a feeling most would probably avoid. Maybe that's what Raphanadosis actually means. I never knew what it was when I was 16 listening when this was on my record player, in fact I always referenced is as SNIT which seems to have disappeared from the brilliant front cover art. It's probably gone for a good reason that I don't understand and that is exactly why this album is so damn brilliant. I never wanted to know who Doctor and the Crippens were really. So stoked I've caught Raphanadosis 26 years later.
Top marks to Boss Tuneage this month who have decided to get this classic out of the punk rock vaults and re-package it for the exploding cabbage appreciation society that followed this seminal bunch of laugh-a-minute punks.
Pick up the re-issue from here. It's a must have double vinyl and CD package that comes with 15 extra tracks from their John Peel Show in (1989), the North Atlantic Noise Attack comp LP and Avant Gardening 12" EP. All that for £8!
Tags album, boss tuneage, doctor and the crippens, download, hardcore, punk, raphanadosis, re-issue
Album Reviews Buzz Chart Reviews
Hey Colossus
'In Black and Gold'
Rocket Recordings
Over the last 11 years, Hey Colossus have become something of an institution in the UK's noise-rock scene. They're absurdly prolific, this is album number nine, devoutly experimental – and heavy as a sack of spanners.
Their growing esteem and popularity likely has much to do with the band's sharp changes in tone and style from LP to LP. Each one takes them into uncharted ground, exposing them to new audiences along the way. Recent releases have even garnered glowing reviews by broadsheets determined to assert their 'cool' – what more could a band so uncompromising and antisocial-sounding ask for?
Yet with 'In Black and Gold', the follow-up to 2013's acclaimed 'Cuckoo Live Life Like Cuckoo' they've managed to deliver a record that pulls beauty from their copious wreckage more so than ever before.
Much of the tonal shift on this latest LP can be attributed to guitarist Jonathan Richards stepping up to provide more of the song writing than on previous outings.
A skateboarder since 1988, Richards intimates that much of his material was developed in his head while on-board: 'The songs feature lots of banks and transitions that came directly from skating. The changes in rhythm and pace as I skated helped develop the blocks of sound that I would eventually translate to guitar when I got home.'
The result is a record that takes in a wide range of styles and moods, whilst managing to retain the trademark meditative aggression the band have developed in recent years.
Live, Hey Colossus have earned a reputation for show-stealing performances that are as unpredictable and confrontational as they are hypnotic. With a UK tour ahead to promote 'In Black & Gold', there's a chance to experience the wall of sound created by this 6-man worrying proposition for yourself.
James Barry
Download the album at Rocket Recordings.
Last two shows sold out in Bristol and London this past weekend. Don't miss out on the rest of the tour dates!
14th Feb – Brighton
18th Feb – Birmingham
19th Feb – Newcastle
20th Feb – Edinburgh
21st Feb – Nottingham
6th March – Manchester
7th March – Shipley
Tags album, download, hey colossus, In Black and Gold
Album Of The Week Album Reviews Buzz Chart Music
Hobo Rocket
(Modular)
Pond share two members with Australian psych-masters Tame Impala but don't for a second think this is some throw-away side-project there to keep the band amused in downtime. Far from it, Hobo Rocket is Pond's fifth album and it's a glorious rush of pop, noise psychedelia that out freaks anything Tame Impala have come up with. Opening song 'Whatever Happened To The Million Head Collide' sets the stall out for the album very quickly, no easing the listener in gently, it slides out of the starting block shimmering with a squelchy Flaming Lips psych-pop vibe, with a pure shot of Butthole Surfers noise running through its veins. This is modern psychedelic music at its best, breathing in fifty years of experimental sounds into their collective lungs and exhaling them all over 2013.
Pond, however, ignore the mistakes of the past and resist the temptation to become self-indulgent and drab, keeping their brand of psychedelia focused and direct. 'Xanman', for example, hits the freak out button hard but remains upbeat and melodic, despite the swirling cacophony of noise the envelopes the song. Next up, 'O Dharma' is a floating Spiritualized type ballad that twinkles like the Lips own 'Waiting For Superman' had it been penned in 1974 by Roger Waters. Then Pond lurch back into the evil lysergic doom of 'Aloneaflameaflower' that crackles with such a mischievous 'I'm gonna fuck up your trip and freak you out' grin, you can't help but love it, before running away feeling a bit paranoid and scared.
This is a good time for psychedelic music. It's good to see the freak flag still waving high.
Tags album, album download, album review, download album, free download, Hobo Rocket, pond, tame impala
Buzz Chart Reviews Single Reviews
letlive.
'Banshee (Ghost Fame)'
The details of letlive.'s long-awaited album 'The Blackest Beautiful' have been creeping across the internet in a sort of unofficial snail trail but this is the first actual music we've had the fortune of hearing. And bloody hell, was it worth the wait. letlive.'s furious melding of punk and hardcore with undeniable R&B influences comes to glorious life in this music video which showcases the band's infamous live abilities. Having said that, the skills on show here are nothing compared to what you will witness at an actual live show so make sure this is one band you catch in the flesh (at the Vans Warped Tour in the US or headlining across Europe in Sept / Oct). They will melt your face off and rip your heart in two (metaphorically speaking, of course).
'Banshee (Ghost Fame)' has a bass driven groove and all the vocal melody, screams and spitting you could want. Jason Butler proves himself as one of the most versatile and skilled vocalists of the genre, whilst purveying some intense lyrical content. You can bet that this is a sign of things to come with the album itself which is set for release through Epitaph Records on 8th July. The term 'highly anticipated' doesn't quite cut it in reference to this record which many are hailing as one of the albums of the decade. On the strength of this introduction, we can see that they might have a point…
2013 belongs to the Soul Punx.
Tags album, banshee 9ghost fame), download album, download letlive album, free download, letlive, review, single review, The Blackest Beautiful, track review, video
'Set Me Back'
Couple Skate Records
Despite struggling to decide whether I love or hate the bands' name, there's no doubting at all how I feel about 'Set Me Back' from Canada's Weed. A stomping, sludgy yet strangely uplifting noise-pop track, 'Set Me Back' is in equal parts hazy and energetic; it's three minutes managing to sound both restrained and powerful. Huge, fuzzing walls of guitars open the track, before the vocals alternate between an almost chanting monotone and a rasping wail – sounding somewhere between the slack trudge of Pavement and the epic shoegaze of My Bloody Valentine. Though cleaner, the production on 'Set Me Back', manages not to lose some of the abrasive edges showcased on their previously released 'Gun Control' EP.
'Set Me Back' is taken from Weed's forthcoming debut album Deserve, coming out in July through Seattle's Couple Skate Records. Here's hoping the rest of the album hits just as hard.
There currently doesn't seem to any plans for the band to come over to the UK, but hopefully it won't be too long before a few dirty East London venues get them on their stages. To save you the hassle of clicking on a whole host of potentially dodgy sites when Googling their band name, find more information about Weed on their blog.
Tags album, "Set me Back", buy weed, buy weed online, Couple Skate Records, deserve, free download, indie, shoegaze, single, smell the glove, stoners, weed
London Posse
'Money Mad'
Let's head back into 1987 when London Posse kicked off a career in Hip Hop that would last a legendary lifetime in British hip hop.
Made up of Sipho, Rodney P, Bionic and DJ Biznizz they kicked off with a self titled release on Big Life produced by a young Tim Westwood followed by the seminal 'Money Mad' on Westwood's Justice Records in 1988 that put Rodney P and Bionic on the map. The Posse may have split leaving these remaining two members but they went from strength to strength to release 'Gangster Chronicle', one of UK hip hop's most cherished slabs of vinyl that is scheduled for a full re-issue treatment on 17th June via Tru-Thoughts.
Keep an ear out for 'Money Mad' with brand new remixes coming from Drumagick and Wrongtom on 13th May and if you don't click on the play button on this documentary you will never know your Tru roots. Support it whilst we try and find out who those skaters are in the opening frames…answers on a postcard please.
Tags album, Bionic, british hip hop, DJ Biznizz, downlaod, free download, Gangster Chronicle, london posse, Money Mad, re-issue, remixes, rodney p, Sipho, Tim Westwood, tru thoughts


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PRLS joins MHSD's Writeshop on PLUC and RLUC
17 Jan 2022 / PRLS (Policy Research and Legal Services)
The Policy Research and Legal Services (PRLS) participated in a Writeshop on Provincial Land Use Committee (PLUC) and Regional Land Use Committee (RLUC) Processes hosted and organized by the Ministry of Human Settlements and Development (MHSD) held in 10th to 12th of January 2022 at Microtel, General Santos City.
The two-part writeshops were spearheaded by experts from the Department of Human Settlements and Urban Development-Region 12 (DHSUD-XII)- resource speakers Jovita G. Solarte, Supervising Administrative Officer, and Alberto P. Sero, Chief of Environmental Land and Urban Planning Division. Both of the esteemed lecturers gave assistance and guidance to MHSD in drafting a proposal of the guidelines for the RLUC/PLUC review processes, adapted for the context of the BARMM.
The said proposal will cover processes on the Review and Approval of Comprehensive Land Use Plans (CLUPs), inter-agency endorsements, checklist guides for Local Government Units upon submission to the MHSD, certifications, and BARMM's own list of review parameters, as discussed throughout the writeshop.
Participants from other offices too such as the Local Government Development Division of the Ministry of Interior and Local Government (MILG), Local Planning and Coordination Division of the Bangsamoro Planning and Development Authority (BPDA), and the MILG-Maguindanao Provincial Office also took part in the said event.
After the writeshop, the PRLS, headed by Mr. Nashrolah Langco from the Office of the Service Director, expressed its support and assistance through a substantive and thorough review of the proposal as part of the action points for review and feedback in the coming weeks before submission of the proposal.
The Comprehensive Land Use Plan (CLUP) is an instrument for the local government unit to allocate available land resources to different sectors of its territory for different functions. It must conform with the provincial and regional land use plans–with focus on identifying areas highly susceptible to calamities and climate change.
As part of its overall preparation, the MHSD has so far extended its technical team to various Local Government Units (LGUs) within BARMM in the profiling of their respective Comprehensive Land Use Plans (CLUP) as well as coaching workshops. The initiative was to identify future interventions and technical assistance that the ministry may extend concerning the updating and approval of their CLUPs and Zoning Ordinances (ZOs).
← In Memoriam of Dr. Samuel K. Tan
PRLS, in collaboration with MILG, conducts Virtual Talk in honor of the 3rd Bangsamoro Foundation Day →


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Been there, haven't done that – 5 things you shouldn't miss in Venice
Post category:Europe / Features / Home / Italy / Places
Continuing our mission to inspire and inform Grown-up Travellers we present the latest in our series of articles containing ideas for alternative things to do and see in well-known destinations. We started our epic journey around the world in good old London, then covered Stockholm, Copenhagen, Berlin, Oslo, Paris, Amsterdam, Chicago and Istanbul. We then hopped over to Australia with guides to Perth, Melbourne and Sydney – before returning to Europe for Belfast and Levi in Finland. After a brief stay in the Middle East for Dubai we ended up in Rome for our most recent article. Italy was so nice we decided to stay – and here take a look at one of the world's major tourist destinations…
Aha. I'm thinking water, and a slowly sinking city?
For once you're right – it's Venice.
And you found something off the beaten track in Venice?
We did. A bit like Rome there is so much to see that something has to be left out when most people visit. But we're not most people, and have gathered some lesser-known sights for you…
5 things in Venice you won't have already in your itinerary *
* at least it's definitely unlikely. If you have heard of all these, you should be writing for us…
Scuola Grande di San Rocco
Image obtained from Flickr.com under Creative Commons (c) J J N
Venice's answer to the Sistine Chapel in Rome is San Rocco, a guildhall which kept Tintoretto occupied for some 23 years. As you enter you are treated to scenes from the life of Mary, including a somewhat horrific 'Slaughter of the Innocents'.
Image (c) museumplanet.com
But make sure you get your breath back before climbing the impressive staircase and taking in the Great Hall as you will likely have it knocked out of you by the stunning decor. As if that wasn't enough, in the side room is a Crucifixion considered by many as Tintoretto's greatest achievement.
Lazzaretto Nuovo
Image obtained from Flickr.com under Creative Commons (c) horitzons inesperats
Ignored by almost every visitor, Lazzaretto Nuovo is in fact one of the great historic sites of Venice and you really should make the effort to check it out. In the past Lazzaretto Nuovo was the Venetian Republic's quarantine island – the city was vulnerable to outbreaks of plague due to its extensive maritime trade and developed clever ways to prevent the spread of the disease. After filling up the original island, in 1468 the senate designated Lazzaretto Nuovo as a quarantine station, where ships arriving from the Mediterranean were required to rest up for 40 days (the term 'quarantine' comes from 'quaranta giorni'). If they were still healthy after this period they were free to go.
These days the island has one inhabitant (and a lot of cats) – Gerolamo Fazzini, a former history teacher who works as island guardian and official guide – a position for which nobody else applied. Fazzini emphasizes that the island is 'an important document in the history of medicine' and that 'guests' were treated surprisingly well. You can view the small houses, each with its own fireplace, kitchen and even a toilet with running water.
Palazzo Loredan graffiti
It's definitely worth seeking out this old piece of Venetian graffiti carved on a column of the Palazzo Loredan, especially when you are familiar with the story behind it. It depicts a man with a long pipe and refers to a local legend about Biagio, a fisherman.
Image (c) telegraph.co.uk
Allegedly Biagio was standing outside the palace one day when Satan – in the form of a monster – reared his ugly head out of the canal and grabbed two young girls from a gondola. Biagio begged him to let the girls go free; but cheeky old Satan said he would on one condition – if Biagio were able to put his arms around the entire world. Rather surprisingly Biagio's arms duly extended from his body and embraced the globe, ably assisted by cherubim. Satan, understandably shocked, disappeared and left the girls and Biagio unharmed.
Gondola workshop
Image obtained from Flickr.com under Creative Commons (c) DarkB4Dawn
There may no longer be as many of them (there were 10,000 two centuries ago) but gondolas remain the symbol of Venice. The boats became the preferred way to navigate the islands of the lagoons when horses were outlawed from the streets in the 14th century. There are just 500 gondolas today – all of which are only used by tourists. A typical gondola is around 11 metres long, weighs about 500 kg, travels about walking pace and is always painted black – the result of a 17th century law to stop owners competing to have the most attractive vessel. Building a gondola takes about two months and when finished it will cost you between €35,000–50,000, depending on whether it's fully-loaded with air con and all the trimmings.
Image obtained from Flickr.com under Creative Commons (c) leonbarnard
It will last you about 15 years, although you'll have to factor in a new coat of varnish every 40 days. If you walk down the Accademia side of the Rio San Trovaso canal you'll find your way to a fabulous gondola workshop. The workmen traditionally hail from Italy's Dolomite region, renowned for producing excellent carpenters. Currently Venice has some 400 licensed gondoliers, and when one passes away the license is transferred to his widow.
San Simeone Piccolo Cemetery
Image (c) navigamus.net
How about something a touch macabre to finish? Yes we thought you'd like that. You'll need to find the San Simeone Piccolo church because there's something spooky hidden underneath it. In fact it houses a cemetery – with walls covered in 18th century frescoes inspired by the themes of death, Christ's Passion and the Last Judgement. Oh and did I forget to mention? It's also filled with human bones. It's not officially open to the public but if you get there at the end of Sunday mass, ask one of the members of the Fraternity of St Peter who take care of the church and they'll probably let you have a peek.
Tags: Gondola workshop, Lazzaretto Nuovo, Palazzo Loredan, San Simeone Piccolo Cemetery, Scuola Grande di San Rocco, venice
30 Places Before 30
The Grown Up's Travel Guide to Edinburgh
The reinvention of the cigar
Passport Stamps 19 Dec 2012
Can't wait to visit.
Steve aka Backpackersteve 30 Jan 2013
Hey there, I've been to Venice around 10 years ago and must say I was pretty dissapointed. From my Point of View it's totally overrated and overcrowded – you might have another experience with this list 😉
Andy Higgs 30 Jan 2013
I had exactly the same feeling the first time I was there. But I was on such a budget (Inter-railing – over 20 years ago) that I couldn't do anything there. The next time I had more money and planned it better; that's the key. There are loads of great things to see – especially like these, a little off the tourist track – but you struggle on a budget 🙂


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EU summit Twitter wall trial goes awry as Berlusconi bashers flood #euco stream
Twitter is undeniably a great way to catch the vibe on what's going on pretty much anywhere in the world, and trending topics and search / hashtags facilitate this tremendously. Kudos to the EU for experimenting with live Twitter stream projections at official summits in that regard … but they still need to learn that moderation is important, too.
Using Tweetwall Pro, a way for event organizers to feed live tweets onto screens, an experiment in the atrium of the EU summit building in Brussels held yesterday didn't quite proceed as planned. The live tweet stream, which was displayed on multiple plasma TVs throughout the building, was abruptly shut down after Italian Twitter users hijacked the #euco stream with anti-Berlusconi messages, calling the politician a mafioso and a pedophile.
Dana Manescu from the Council press team, who organized the trial run of the technology, told news site EUobserver:
"We had the tweet-wall up for two hours in the main hall, but it wasn't moderated and a lot of the tweets were, well, very, very frank."
You can find some of the tweets found by EUobserver in the article linked above, but most seemed to revolve around Berlusconi's alleged mafia connections, recent vote-buying activities and paying for sex, among others. It didn't stop there:
"It was insulting. People were calling him a paedophile," Ms Manescu said. "The point was not to show insulting messages about Berlusconi. If anyone from the Italian delegation saw it, it would hurt their sensibility. It was off topic and basically spam."
Fortunately, the whole situation didn't scare the press team away from using Twitter in the future entirely, as Manescu said they will definitely try to do this again after careful evaluation of what went wrong.
My guess is that, considering the raw, real-time aspect of showing live tweets on screens, the experiment won't be repeated as it was handled yesterday any time soon.
For what it's worth, Tweetwall Pro says they have tools for live and automatic moderation in place, but says the press team didn't feel they would need to moderate the conversation.
You live, you learn.
TweetWall Pro


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Man's House Gets Broken Into, Cop Responds and Shoots Family Dog
WATCH: Road Raging Cop Beats Innocent Cancer Patient for Telling Him to Slow Down
Multiple Cops Indicted for Policy of Framing Innocent Black People to Make Dept Look Good
Police Slammed for Tasing Unarmed Black Man as Video of Him Writhing in Pain Goes Viral
WATCH: Police Chief Calls Press Conference and Then Arrests Everyone Who Showed Up
A Texas man called police to report that his home had been burglarized. The responding deputy arrived and promptly shot the man's dog.
Lily Dane | Lily Dane
Last Friday morning, Cole Middleton arrived home around 11 to find that his home had been broken into. His guns and iPad were stolen, along with his wife's jewelry. He called 911.
Middleton, a farmer and cattle rancher, decided to help his grandfather harvest silage during the 2.5 hour wait for the police to arrive.
When Rains County Deputy Jerred Dooley finally showed up, Middleton and his father were working in a nearby field. The family's little three-year-old Blue Heeler dog, Candy, ran to see who arrived on their property, like dogs typically do.
Middleton told KLTV what happened next:
"She's barking when he pulls into the driveway letting me know someone's at our house, an intruder is here, or a person who she would think was an intruder that she's unfamiliar with. She's barking. The officer gets out of his car, and all the while we're headed up [there]. He gets out of his car and shoots my dog in my front yard."
Middleton and his father both witnessed Dooley's arrival on their property. They say the deputy stuck his head inside the door of the house, which was about 40 yards away from the field the in which the men were working. Candy jumped out of the back of the pickup truck she was sitting in, and ran towards the house, barking.
By the time Middleton and his father caught up with her, it was too late. She was dying of a gunshot wound to the head.
"I shot your dog, sorry," said Dooley.
Middleton said Candy was shot behind her ear, which he believes means she was not facing the deputy.
That wound didn't kill Candy, though, as Middleton explains:
"I was so upset. I went over there to her and she was still alive and I begged and pleaded with him to please shoot her again because I don't have any firearms. They got stolen. He went and got in his vehicle and backed out of my driveway.
And then I had to do the unthinkable, the otherwise unthinkable. I had to kill my dog with my bare hands and put her out of her suffering, praying for this to be over with."
Dooley went to his car and called for backup, and ordered Middleton and his father "do not approach" his vehicle.
PoliceStateUSA described what happened next:
According to the rancher's account, 3 additional police officers arrived in separate vehicles. A state trooper named Hayes allegedly pulled up and immediately threatened the grieving family with a drawn taser.
Middleton described the four officers as "very intimidating" and decided that documentation was necessary and began filming the encounter with his cell phone. Video shows Trooper Hayes, with his weapon still drawn, mocking the victim by looking into the camera, saying: "Hi mom! Hi Channel 8! How you doing?"
"He pulls up to my place and shoots my damn cow dog," an upset Mr. Middleton told the other officers. "The man pulled up without cause and shoots my dog."
"I had no choice. I wasn't gonna get bit," Dooley attempted to explain.
Middleton documented the incident in a detailed Facebook account. "When we call on peace officers for their help and assistance we expect them to serve and protect us, especially if we are the victims," he wrote. "Serve and Protect? More like Invade and Attack."
Middleton and his wife Jayna buried Candy at the foot of a tree where they had spent time together.
"It's just terrible," Middleton said.
Rains County Sheriff David Traylor refused an on-camera interview with KLTV. He said the case is now being investigated by the Texas Rangers.
When it comes to family pets, it seems that many law enforcement officers use the "Shoot first, ask questions later" approach.
Why are cops so afraid of family dogs? There is not a single documented case of a law enforcement officer being killed by a dog. Yet, some groups have attempted to count how often dogs are killed by cops, and they estimate that a dog is shot by law enforcement every 98 minutes.
"I'm sorry" just doesn't cut it. How about training officers how to peacefully handle family dogs, or at least teaching them how to differentiate between threatening and normal canine behavior?
Contributed by Lily Dane of The Daily Sheeple.
Lily Dane is a staff writer for The Daily Sheeple. Her goal is to help people to "Wake the Flock Up!"
Related Topics:dog shot, police misconduct, police shoot dog, police training
Lily Dane
Lily Dane is a staff writer for The Daily Sheeple. Her goal is to help people to "Wake the Flock Up!"


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De Bolensteinseweg  is een straat in het Nederlandse dorp Maarssen. Deze loopt van de Wilhelminaweg, Schippersgracht en de Vecht tot aan de rotonde Straatweg. Aan de Bolensteinseweg bevinden zich talrijke panden waarvan een aantal met status van rijksmonument. Deze straat heeft zijn naam te danken aan huis Bolenstein, ook wel Boelestein. Zijstraten van de Bolensteinseweg zijn Bolensteinsestraat en Gaslaan.

Straat in Stichtse Vecht

redpajama_set_name: RedPajamaWikipedia


text:
Les maladies génétiques du métabolisme des nucléotides comprennent les maladies génétiques en rapport avec le métabolisme de la purine et de la pyrimidine

Trouble de métabolisme des purines

Trouble du métabolisme des pyrimidines

Sources
  Site français sur les maladies rares
  Site sur la biochimie
  Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD.

Nucléotides
Nucléotide
Nucléotide


Deepak RAO has a 'Bull Run', with Standard Chartered Mutual Funds.
RAO is booked for 10 shows covering Bombay, Delhi, Calcutta, Chennai, Bangalore, Pune, Cochin, Ahmedabad, Hyderabad, Goa.
Deepak RAO zapped 50 of Stan Chart MF's most exclusive clients and senior management.
It was (rather is) a memorable evening in my life, with Standard Chartered Mutual Fund.
Mr. Deepak, can you name me a book or a website on "getting back to sales success especially in Life Insurance & Mutual Fund Business" ?
I wish to acclaim MDRT & COT with TOT in Life Insurance.
Thank you again and I wish you all the very best with ample GOOD LUCK in your Life!
Attended Mr. Deepak Rao's Mind Show, yesterday.
Found it impressive & interesting.
We are interested in knowing more about it.
Yesterday, I enjoyed your presentation.
I had a great experience in your session for Stanchart Mutual Fund.
Once again the session of really amazing.
It was a nice show at Standard Chartered Mutual fund.
Though I was seeing your programme for the second time, after the show at Western Union programme almost a year back, I am still wonderstuck.
Anyway, I liked it and thanks for the same.
COO. Wall Street Finance Ltd.
On 15th Oct '05, at one of Cochin's most exotic hotels - The Kumarkom Lake View Resort, Deepak RAO zapped 50 of Stan Chart MF's most exclusive clients and senior management.
Such was the 'Shock & Awe' response.... that RAO was booked again for another Client Meet, at the ITC Sheraton, on 27th Oct 05.


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Cedar Point è un census-designated place (CDP) degli Stati Uniti d'America della contea di Polk nello Stato del Texas. La popolazione era di 630 abitanti al censimento del 2010.

Geografia fisica
Cedar Point è situata a  (30.797535, -95.074909).

Secondo lo United States Census Bureau, il CDP ha una superficie totale di 4,83 km², dei quali 2,34 km² di territorio e 2,48 km² di acque interne (51,45% del totale).

Società

Evoluzione demografica
Secondo il censimento del 2010, la popolazione era di 630 abitanti.

Etnie e minoranze straniere
Secondo il censimento del 2010, la composizione etnica del CDP era formata dal 95,08% di bianchi, il 2,54% di afroamericani, lo 0,32% di nativi americani, lo 0,48% di asiatici, lo 0% di oceanici, lo 0,79% di altre razze, e lo 0,79% di due o più etnie. Ispanici o latinos di qualunque razza erano il 5,71% della popolazione.

Note

Collegamenti esterni

Census-designated place del Texas


text:
Rooms, Hotels
Hotel Chain Accor Ignores Big Chinese Cities for Bigger Chinese Tourist Sites
David Fickling, Bloomberg
- May 27, 2014 3:00 am
Accor is betting on boring middle class travel in China. If they don't benefit from this book, some will.
Accor SA will build about a third of its 100 planned Chinese hotels in tourist destinations as rising wealth in the country leads to growing leisure travel and oversupply in cities depresses room tariffs.
Domestic tourism in the country is "growing at a rate of knots," Michael Issenberg, chairman of Accor Asia-Pacific region, said in a May 22 interview in Sydney. That's making tourist spots more attractive than many urban sites, he said.
"If people acquire wealth, they want to travel," Issenberg said. "That's been the big change. Even five years ago, it was all cities."
Europe's largest hotel operator has already opened sites on ski slopes near the North Korean border, a beach resort on tropical Hainan island, and a central Chinese forest park among its 128 hotels in the country. That'll help it capitalize on domestic tourist trips that are forecast to grow by about 11 percent a year between 2013 and 2018, according to data from Euromonitor International.
Other international leisure companies are also targeting China's domestic tourist market. Carnival Corp. will dispatch a fourth cruise ship for the country next April and Walt Disney Co. plans to open a $5.5 billion theme park resort in Shanghai during 2015.
Hennes & Mauritz AB, the Swedish fashion chain, has opened a store in Zhangjiajie, which serves central Hunan province's scenic Wulingyuan national park. The town is also home to an Accor Pullman hotel.
Largest Market
China overtook Germany in 2012 to become the largest outbound tourism market, according to the United Nations World Tourism Organization. International spending by Chinese travelers rose 26 percent during 2013 to $129 billion, the agency said May 14.
Expansion by domestic and international companies in China has slowed some hotel operators' ability to increase room rates.
At InterContinental Hotels Group revenue per available room in Greater China rose just 0.7 percent from a year earlier in the third quarter of 2013, according to company filings.
Hotels in the densely populated east of China filled about 64 percent of rooms during April. That compares with occupancy rates of about 70 percent in Accor's economy hotels globally and 68 percent in its upper- and mid-market locations during 2013, according to a company presentation in January.
'Chronic' Oversupply
"The oversupply can be chronic if things keep getting built, but if the supply even starts to moderate, demand will catch up," Issenberg said. "If you ask anybody, ''If you had more time or money what would you do?'' almost everybody says travel."
The chain is also building six new hotels in Myanmar amid rising foreign investment in the country, he said. A first site will open next month in the capital Naypidaw with others to follow in Yangon and the scenic Inle Lake.
Setting up credit-card payment networks, getting insurance and training workers in hygiene is still a challenge in a country that has little experience with tourism, he said.
Myanmar had about 36,177 tourist arrivals during August 2013, the most recent month for which data compiled by Bloomberg is available, compared with 2.4 million during the same month in neighboring Thailand.
"I went in December, and a hotel we were visiting had an ATM machine and was really excited" about it, Issenberg said referring to Myanmar. "That tells you the state of the country, that this is big news that you can actually get cash."
To contact the reporter on this story: David Fickling in Sydney at dfickling@bloomberg.net. To contact the editors responsible for this story: Anand Krishnamoorthy at anandk@bloomberg.net; Stephanie Wong at swong139@bloomberg.net.
Stay up-to-date on the business of travel in Asia with our weekly newsletter straight from Skift's Singapore bureau.
Tags: accor, china, development
Photo Credit: RECEPTION CLUB ACCOR HOTEL. Mercure Hotels staff greeting a guest who checked in online before arrival. Accor Hotels
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