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XVIIIth International Conference on Ultrafast Phenomena
Chemistry – Condensed Phase
J. Friedrich, S. Glib, O. T. Ehrler, A. Behrendtand M. M. Kappes, "Electronic Photodissociation spectroscopy of isolated IrX62- (X = Cl, Br)", J. Chem. Phys. 117, 2635 (2002). [CrossRef] [Google Scholar]
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I. P. Pozdnyakov, E. M. Glebov, V. F. Plyusnin, M. V. Tkachenko and H. Lemmetyinen, "Primary Processes in Photophysics and Photochemistry of PtBr62- Complex Studied by Femtosecond Pump–Probe Spectroscopy", Chem. Phys. Lett. 442, 78 (2004). [CrossRef] [Google Scholar]
G. A Worth and L. S. Cederbaum, "Beyond Born-Oppenheimer: Molecular Dynamics through a Conical Intersection", Annu. Rev. Phys. Chem. 55, 127 (2004). [CrossRef] [PubMed] [Google Scholar]
C. G. Elles, I. A. Shkrob, R. A. Crowell, D. A. Arms and E. C. Landahl, "Transient X- Ray Absorption Spectroscopy of Hydrated Halogen Atom", J. Chem. Phys. 128, 061102 (2008). [CrossRef] [PubMed] [Google Scholar]
Towards Controlling Photochemical Reactivity in Small Polyatomic Molecules in Solution: Difluorodiiodomethane
Ultrafast One-Photon (232 vs 266 nm) Bond-Selective Photochemistry of Bromoiodomethane (CH2BrI) in Solution
Influence of the Chemical Design on the Coherent Photoisomerization of Biomimetic Molecular Switches
Mixed Potential Energy Surfaces of the Ultrafast Isomerization of Retinal in Bacteriorhodopsin
Ultrafast spectroscopy of UV-induced DNA-lesions — on the search for strategies which keep DNA alive

redpajama_set_name: RedPajamaCommonCrawl


It's hard to imagine a more beautiful place than the Stonington area in southeastern Connecticut. A sense of history pervades its quaint villages where grand colonial homes from another era stand proudly by the sea. Stonington's country roads run alongside ancient stone walls, which once earmarked boundaries to the bucolic farmlands that dominate the area. They connect the borough of Stonington, Mystic, Pawcatuck, Lords Point, and Wequetequock.
The main street of Stonington borough is bordered on both sides by the ocean, where lucky homeowners enjoy the vista of sailboats bobbing in the surf beyond. Many of Stonington's homes are on the National Historic Register and several are used as second homes during the summer season. If looking to a beautiful place to call home, whether year-round or during the summer months, it doesn't get much better than life in the borough or nearby villages.
Just a ten-minute ride from Stonington borough is historic Mystic, the area's most well-known village. Thousands of visitors travel over the drawbridge each year to reach the heart of this maritime jewel. Unique boutiques, interesting museums and fabulous restaurants like Mystic Pizza, made famous by Julia Robert's movie of the same name, grace Mystic's waterfront. Mystic's lucky homeowners have all these amenities at their front door. Mystic is also home to Randall, Realtors Mystic office, where you can begin your search for the home of your dreams.
With its fabulous location, beautiful homes and superior school system, why wouldn't you want to call Stonington area home? Call Randall, Realtors Mystic office at 860-572-9099 to put our professional expertise and knowledge of the local area to work for you.


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Moralisk risk, eller den vanligare engelska termen moral hazard (som korrekt översatt betyder moralisk fara), är ett samhällsvetenskapligt begrepp, som används särskilt inom nationalekonomisk teori.

Moralisk risk uppstår när en part i ett avtal kan öka sin nytta genom att dra nytta av positiva konsekvenser av riskfyllda handlingar men där eventuella negativa konsekvenser delvis eller helt drabbar en eller flera andra parter. Den ena parten sägs då vara beroende av motpartens moral, på så vis att denne uppgett all relevant information för den andra parten.

Ett exempel på moralisk risk är en arbetsgivare som utfäster sig att betala de fortkörningsböter som en arbetstagare ådrar sig i tjänsten, utifrån en förväntan om att arbetstagaren inte kör fortare än den genomsnittlige föraren. Arbetstagaren kan dra nytta av utfästelsen genom att förändra sitt beteende och köra mycket fort mellan möten och därmed prestera fler möten, medan arbetsgivaren får ta kostnaden för eventuella fortkörningsböter som det förändrade beteendet resulterat i.

Ett exempel på när moralisk risk på flera nivåer sammantaget resulterade i stora samhällsproblem, kostnader och förmögenhetsöverföringar var finanskrisen 2007-2008. Amerikanska bostadsfinansieringsinstitut lånade då ut pengar till bostadsköpare med bristfällig bedömning av bostadsköparnas förmåga att återbetala lånen. Dessa lån kallades för subprimelån. Lånen hade en återbetalningsklausul som innebar att om låntagaren inte kunde betala räntor eller amorteringar, kunde låntagaren bli kvitt sin återbetalningsskyldighet genom att överlåta ägandet av bostaden till långivaren. Den bristande kreditbedömningen hos kreditgivarna kombinerat med möjligheten att kvitta återbetalningsskyldigheten mot "nycklarna till bostaden" utnyttjades av bostadsköpare till att finansiera bostadsköp som översteg låntagarnas återbetalningsförmåga, utan att bostadsköparna behövde bära den fulla finansiella risken till följd av bostadsköpen. Det var en moralisk risk. När konjunkturen sedermera vek och arbetslösheten steg, resulterade det i att många bostäder överläts till bostadsfinansieringsinstituten efter att låntagarna drabbades av arbetslöshet eller av andra orsaker fick betalningssvårigheter. Bostadsfinansieringsinstituten i sin tur sålde de överlåtna bostäderna exekutivt. De exekutiva bostadsförsäljningarna resulterade i att priserna på bostäder föll snabbt och bostadsfinansieringsinstituten (eller de de sålt krediten vidare till) ådrog sig mycket stora kreditförluster till följd av låntagarnas bristande återbetalningsförmåga.

I efterhand konstaterades att finanskrisen 2007-2008 orsakats av moralisk risk på flera nivåer, bland annat till följd av bostadsfinansieringsinstitutens försäljningsmetoder. Bostadsmäklare som lät sina kunder finansiera sina köp hos bostadsfinansieringsinstituten erhöll provisioner samtidigt som bostadsköparna erhöll rabatter på räntor och anstånd med amorteringar under en inledande period på bostadslån med lång löptid. Provisionerna till bostadsmäklarna utbetalades oavsett om lånen senare gav upphov till kreditförluster, vilket utgjorde moralisk risk. Även bostadsfinansieringsinstitutens interna bonussystem hade givit upphov till moralisk risk genom att personal med beslutsansvar hade erhållit lönebonusar kopplade till kortsiktiga låneförsäljningsresultat, medan bostadsfinansieringsinstituten drabbades av de kreditförluster som uppstod till följd av den framgångsrika låneförsäljningen.

Även hos många banker hade moralisk risk bidragit till finanskrisen 2007-2008 när de genom finansiella derivattransaktioner tagit stora kreditrisker förknippade med subprimelånen. Chefer och tjänstemän hade erhållit bonusutbetalningar som var relaterade till bankernas provisionsintäkter på derivattransaktionerna, medan bankerna drabbades av de kreditförluster som senare uppstod. Moralisk risk bidrog bland annat till att den amerikanska investmentbanken Lehman Brothers sedermera gick i konkurs.

Moralisk risk är ofta intimt förknippat med brist på eller undanhållande av information som är avgörande för att parterna i ett avtal ska kunna bedöma och värdera olika möjliga framtidsscenarier. Moralisk risk kan även uppstå till följd av strukturella brister i regleringen av marknader, som var fallet i finanskrisen 2007-2008.

Termen används om situationer då endera parten i ett ingånget avtal, ofta i marknaden för försäkringar, ändrar sitt beteende efter att till exempel ett kontraktet signerats, så att de sannolikheter som tillskrivits endera partens sätt att agera inte längre gäller.

Definition
Moralisk risk uppstår på grund av att en individ eller institution inte drabbas fullt ut av de negativa effekterna av sitt eget handlande. Därmed får individen eller institutionen ett incitament att handla mindre försiktigt än om individen eller institutionen drabbats fullt ut av negativa effekter av sitt eget handlande. Ofta är det motparten i en transaktion eller ett avtal som drabbas av de negativa konsekvenserna av den förstes handlande. De negativa effekterna utgör en extern effekt om hänsyn inte kan tas till den moraliska risken när avtalet ingås. Moralisk risk är ett betydelsefullt marknadsmisslyckande och kan ses som en variant av snedvridet urval.

Begreppshistoria
Enligt forskning av Dembe och Boden kan termen dateras tillbaks till 1500-talet. Den engelska motsvarigheten nyttjades flitigt bland de engelska försäkringsbolagen under sent 1700-tal. Tidigt användande av terminologin bar en negativ klang och åsyftade på bedrägeri eller omoraliskt beteende, vanligen mot den försäkrade delen.

Konceptet moralisk risk blev ämne för förnyade studier av nationalekonomer på 1960-talet och hade inte innebörden om omoraliskt uppförande eller bedrägeri vid denna tidpunkt utan de använde termen mer för att beskriva ineffektivitet som kan uppkomma då risker är förskjutna eller undanträngda mer än etiken eller moralen hos de involverade parterna.

Inom finans
Moralisk risk är utsikten att en part som är isolerad från risk kan bete sig annorlunda än hur den skulle bete sig om parten var fullt utsatt för risk.

Inom ledarskap
Moralisk risk kan uppkomma då en högre chef eller ledare är skyddad från konsekvenserna av dåligt beslutsfattande.

Inom försäkring
En typisk situation är när en försäkringstagare tar större risker än han annars skulle göra eftersom han vet att han skyddas av försäkringen. Ett exempel är om en individ  tecknat en tandvårdsförsäkring och därefter låter bli att sköta sina tänder lika noggrant som innan eftersom den ekonomiska kostnaden av hål i tänderna bärs av försäkringsbolaget. Vanligtvis motverkas detta beteende genom självrisker och/eller samförsäkringspriser, vilket i praktiken innebär ofullständig täckning av försäkringen. Moralisk risk kan också leda till att den som tecknar försäkringen, försäkringstagare, lämnar oriktiga uppgifter när försäkringen tecknas eller i samband med att en skada regleras. Det kan också leda till att försäkringsfall simuleras eller framkallas avsiktligt.

Se även
 Asymmetrisk information
 The big short (2015) - skildrar moralisk risk under finanskrisen 2007–2009.

Källor

Nationalekonomi
Marknadsmisslyckanden
Risk

redpajama_set_name: RedPajamaWikipedia


The epigenome is responsive to a wide range of environmental factors, including toxicant exposure, diet, stress, and socioeconomic circumstances. Traditional toxicological paradigms have relied on factors such as age, genetic polymorphisms, and disease status to identify variability in responsiveness to environmental toxicant exposure; however, these factors are neither sufficient to faithfully identify differentially responsive individuals, nor are they modifiable factors that can be leveraged to mitigate adverse health effects of toxicant exposures. An individual's epigenome, on the other hand, can be shaped by interactions with chemical and nonchemical aspects of the environment, giving it potential as a tool for the promotion of public health. The field of toxicoepigenetics is fastly evolving to provide novel insights into the mechanisms underlying exposure‐related susceptibility and disease.


I'm down with the LMC--let me hear you say Large Magellanic Cloud. I took some wide field images of a small portion of the LMC, centered on the Dragon's Head Nebula (NGC2035), that colorful stretch of star-forming cloudiness in the middle of the pic. Astro specs: 8 stacked 300 sec exposures, Takahashi SKY90 APO, SBIG ST2000 XMC camera, Paramount PME.
Now, before you go thinking that I've teleported to the southern hemisphere, which is where you have to be to see our nebulous galactic neighbor, the Large Magellanic Cloud, I assure you I haven't. I have merely bought a tiny slice of observatory time on some fantastic hardware that happens to be located at the Siding Spring Observatory, New South Wales, Australia.
I will also tell you that I can fly from here to Australia seven or eight times--first class--for what that equipment setup costs. It's so much easier pretending to be there under the stars near Coonabarabran, using some totally badass astronomical gear. And it's easy, and inexpensive. Besides, it's pouring rain here, and I miss seeing the sky. Wait, I don't have to justify my imaginary stargazing trip to Australia to you! Go check it out yourself: https://www.itelescope.net (The observatory in Spain is lovely as well).


Zebrafish (Danio rerio) are an ideal model organism for disorders in various human body systems and neurodegenerative diseases. Despite the wide use of zebrafish as a model and the near complete zebrafish proteome, to date, N-glycosylation in zebrafish has not been studied.1,2 Comparisons of proteins in zebrafish and mammals show that proteins are conserved.3 Further understanding of N-glycosylation in zebrafish could bring important insights for human disease states.
Baycin-Hizal et al.4 sought to characterize N-linked glycoproteins involved in zebrafish development and identify glycosylation sites. Wild-type fertilized zebrafish embryos were prepared by homogenization, and then proteins were extracted, denatured, and digested with two proteases, trypsin and chymotrypsin, to increase the number of glycopeptides.
Following the use of SPEG, analysis of glycopeptides took place on a LC MS/MS on an LTQ Orbitrap Velos (Thermo Scientific). Samples were analyzed three times to assess the reproducibility and validate the peptides and glycosylation sites discovered.
A total of 855 peptide identifications were assigned using trypsin and chymotrypsin digestion after comparison against the NCBI database and MASCO software. This total included 265 unique glycopeptide sequences and a number of duplicate glycopeptides. Of those 265 sequences, 269 glycosites and 169 N-glycosylated proteins were identified.
The SPEG method was further demonstrated by the discovery of 676 peptides, which included consensus N-X-S/T glycosylation sites. This supported the capability of the SPEG method to enrich the N-linked glycopeptides containing consensus N-linked glycosylation sites.
The identified proteins were categorized into groups based on their functionality. The gene ontology groups included transporters, cell adhesion, ion channels and ion binding, lipid metabolism, development, and receptors. 19.3% of proteins were previously uncharacterized and were placed in the unknown function group.


The feminine type has been represented in artistic endeavors for hundreds of years. The images at the moment are taken for skilled as well as personal causes, and a superb glamour photograph will at all times current a girl in a sublime and dignified light. With that strategy to photography, not all artists will admit that your work has a creative contact, however when you take the definition highlighted above, the extra components and the intent will be nature itself.
If you happen to photographed your art exterior on a cloudy day and you were near a red wall, your photos may have a crimson overcast. And remember that the exercise above, for considering and 'seeing' in new methods, might be executed nearly any time and anyplace, not simply once you're taking pictures.
four. Use the sunshine: In the event you realized the best way to make the most of a light-weight supply and utilise the supply of light whether it is a pure supply just like the solar or an artificial source of sunshine like a lamp or something, you can make an bizarre image look extraordinary.
As a tremendous artwork photographer you should examine the picture fastidiously by way of the viewfinder so as to preview what the camera will report and be delicate to any elements that will not be recorded as the eye perceives them. While a complete host of studio "tricks" and software program "improvements" are used commercially, by some easy techniques and efforts the pictures of girls might be achieved with nice outcomes.
Do not misunderstand, I claim no pretense to full competence for any besides images. Many faculties also provide courses in illustration, documentary film making strategies, designing, business promoting, presentation abilities, business abilities, photojournalism, and easy methods to set up a studio for aspiring photographers.


text:
John Fogarty
Tony Leen
Kieran Shannon
Anthony Daly
John Divilly
Donal O'Grady
Enda McEvoy
Pat Keane
Larry Ryan
Ruby Walsh
Michael Moynihan
Brendan O'Brien
John McHenry
Liam Brady
Liam Mackey
Paul Rouse
Ronan O'Gara
Donal Lenihan
Tommy Martin
PM O'Sullivan
Éamonn Fitzmaurice
Derek Coughlan
Daniel Storey
Colin Sheridan
Chris Hatherall
Brian Gavin
Oisin McConville
Derek McGrath
Ger Cunningham
Ed Coughlan
Conor McCarthy
Tadhg Coakley
Graham Cummins
Neal Horgan
Home»sport
Fit-again Jack Kennedy proves class really is permanent
Jack Kennedy celebrates on Delta Work after winning the Savills Chase at Leopardstown. Picture: David Fitzgerald/Sportsfile
By Darren Norris
Irish Examiner Reporter
Follow @Denmania
Sunday, December 29, 2019 - 09:25 PM
Sometimes you have to go through hard times to truly appreciate good ones.
Just ask Jack Kennedy.
The Dingle native was only 17 when he first tasted glory at the Cheltenham Festival, steering the quirky Labaik to a shock victory in the Supreme Novices Hurdle in 2017.
A year later, he left the Mecca of jumps racing having booted home four winners, one of whom was festival banker Samcro.
Pressure? What pressure?
Kennedy returned to Prestbury Park last March but left without a single winner.
That's Cheltenham, magical one year, callously brutal the next.
This year brought other challenges, a frustrating run of injuries, most recently breaking a collarbone for a second time, denying him the momentum every jockey needs to excel.
This Christmas didn't start great either, the much-hyped Samcro finding the ageing Faugheen too fast for him at Limerick on St Stephen's Day.
Kennedy's luck finally turned at Leopardstown on Friday, Abacadabras providing the Dingle man with a timely Grade One success and Roaring Bull swooping late to land the Paddy Power Chase.
His prospects of further big-race success on Saturday looked slim. Apple's Jade went into Frank Ward Memorial Hurdle under a cloud, having looked a shadow of her brilliant best in her five previous runs.
She was, we would later learn from owner Michael O'Leary, in the last chance saloon, one more bad run would bring about retirement.
Things were not quite so desperate with Delta Work but he went into the Savills Chase with much to prove having disappointed on his seasonal reappearance at Down Royal last month.
But, to quote the old maxim, form is temporary, class is permanent. With Bacardys badly out of sorts, the value of the form of the Frank Ward Memorial Hurdle could be questioned but the rapturous reception the 16,251 people gave Apple's Jade on her return to the winner's enclosure spoke volumes about the enduring popularity of Gordon Elliott's magical mare.
From a strict form perspective, it was a similar story with Delta Work.
Beating an exposed rival in Monalee by a head doesn't scream Gold Cup winner in waiting but for Kennedy, who was completing a treble on the day having also scored on the Dermot Weld-trained Dalton Highway in the Irish Daily Star Christmas Handicap Hurdle, it was a special moment.
"That's as good as you'll get, I can't believe it," the 20-year-old said. "Everything's gone to plan today so it's great. I was probably a little bit closer than I wanted to be (with Delta Work), he was in my hands a little bit, but he was jumping so well.
"We went steady enough and he can be a keen horse. But he was jumping so well I was having to take him back at the back of fences so that's probably why he got lit up a bit but it all worked out."
Reflecting on Samcro's shock defeat and perhaps on some level his own injury travails, Kennedy added: "You can't dwell on disappointments, you have to get on with things, there's more to it than one horse and you have to focus on what's ahead of you."
Unsurprisingly, Elliott was quick to pay tribute to his jockey.
Jack is riding out of his skin, he's had a lot of bad injuries, but it's good to see him back riding like this. He's a top-class jockey.
Whether Delta Work is a top-class chaser remains open to debate but with the Cheltenham Gold Cup picture looking so muddled, he certainly deserves to be considered a contender.
"We thought he was a Gold Cup horse last year and our bubble got burst in Down Royal, but we're not gone yet. You've got to have faith in your horses," Elliott said.
Given her recent form, keeping the faith with Apple's Jade required a leap but Elliott believed and was rewarded with the mare's 11th Grade One success.
He wasn't the only one who belied either as Apple's Jade was backed into 6-4 co-favourtism and won by no less than 17 lengths despite continuing her tendency to give away ground by jumping markedly to her right.
"It's brilliant," Kennedy said. "I know she's had a couple of disappointing runs but she put that behind her today and showed her class. She carried me today whereas she didn't the last day. She seemed to be back to the way she always was, I was always happy on her. You grow up watching horses like her on the telly and to be associated with one like that is unbelievable."
O'Leary was similarly delighted. "She jumped really well today. She may have jumped out to her right but she was kind of making ground at her hurdles. She seemed really keen. She was fairly lifeless, I thought, in Fairyhouse and Navan which is not like her. But it looks like she's back which is great.
"It's a great training performance by Gordon, there was clearly something wrong with her and hopefully the treatment for ulcers has fixed it.
"Today's a great bonus, it's wonderful to see her back. I'd imagine she'll run back here in February, I can't imagine she'll go to Cheltenham but that will ultimately be Gordon's decision.
"One more bad run and she is getting retired but if she runs like that and jumps like that then we'll keep going. You know yourself, it's like with all ladies, when they decide they've had enough they've had enough! I can't persuade them to do any more."
Nor can O'Leary be persuaded to reconsider his decision to wind up his Gigginstown operation. And if a day like Saturday couldn't do it, surely nothing will.
Asked if the obvious enjoyment his children took from a day to savour might tempt him to reverse his decision to exit the scene, O'Leary replied: "Unfortunately, my children love winning. They're very happy to come up here when there's a presentation of a trophy to be got but you don't see them too much in the unsaddling enclosure (for the losers).
The conversation going home in the car will be 'where can we have pizza, can we go and see the new Star Wars movie before New Year's Eve'. They couldn't care less about the racing.
But will he miss the feeling of excitement winning brings?
"You'll always miss the feeling but I've had a lot of those feelings, a couple of Gold Cups, a couple of Grand Nationals — it doesn't go on. I get more satisfaction and a buzz now out of my children running around on a wet field, that's where I get the buzz now, but these are great days."
That they are but, while O'Leary's days in the racing game are now numbered, the same, fitness permitting, can't be said of Kennedy. This year may have tested his patience but a Grade One double and an 88-1 treble on one of the biggest days in the Irish racing calendar is some way to end it.
The decade ahead could be his.
Dublin Racing Festival: Big guns stand ground in Gold Cup
Bristol De Mai the choice in tricky affair
Pat Keane: Footpad is now one to be avoided at all costs
Ruby Walsh: Hard to get away from Stormy Ireland
TOPIC: Horse Racing
Solskjaer hoping memories of PSG comeback can spur Man Utd to overcome City
AC Milan honour Bryant at Coppa Italia tie
Trezeguet scores late winner to send Aston Villa to Wembley
Mayo record against Dublin 'a monkey on the back'


Of course, the objective of SDN is to manage routing centrally on the network, thus supporting configuration across multiple network nodes. Because this is a difficult task at the command line, the project also comes with a web interface known as DLUX. DLUX runs as a feature or module; it was enabled in the previous installation with odl-dlux-all.
You can type http://<IP_address>:8181/dlux/index.html to log on via the web interface. On the start page, the system shows the topology of the network structure that it has identified (Figure 1). You should see all the nodes registered on the network. Mousing over a host or switch pops up a tool tip with more information. To enter a static route, change to the Network menu item and click Static Routes (Figure 2). In the dialog, you can then enter the name, network, netmask, and hop count.
Figure 1: OpenDaylight showing the network topology in the DLUX web GUI.
The Subnets tab lets you create various subnets, and you can also specify the Gateway IP (Figure 3). The central settings help you create rules for the data traffic that OpenDaylight then distributes to all nodes involved via OpenFlow. You don't need to worry about which switches are connected to which device. OpenDaylight as the control plane takes care of all that.
Figure 3: … and additional subnets.
SDN breaks with the typical network and data traffic paradigm. Abstracting the data plane from the control plane allows totally new approaches in the implementation of the infrastructure. Thanks to centralized management, administrators can respond quickly to changing requirements and control the data traffic across many devices independent of the physical location.
Major IT corporations have cooperated on OpenDaylight and – based on the OpenFlow protocol – created a solution that allows administrators to combine arbitrary hardware, which they can then manage using OpenDaylight as the control plane. The implementation as a Java application and modularization through features make it possible to implement SDN in a targeted way to reflect the current network requirements.
Even though OpenDaylight is very easy to set up and manage, migrating to SDN or setting up a new SDN environment is a task that is not to be taken lightly. Before embarking on such a project, the stakeholders need to investigate the benefits and drawbacks for their in-house IT services and network infrastructure. Beyond this, it makes sense to call in experts at an early stage. Taking the next steps toward SDN means ditching traditional approaches and thinking outside of the box. Once you have this kind of atmosphere in place, OpenDaylight can be a very flexible solution for setting up your SDN and making any necessary modifications quickly and easily on the fly.


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redpajama_set_name: RedPajamaGithub


Are you and the other members of your band booster club looking ahead to the festivals, competitions, and invitationals coming up this winter? Although it's exciting, you might find yourself scratching your head, wondering how you're going to afford these opportunities.
We've got some ideas for raising money for these expenses. Separately, these fundraising options might seem like slow earning, but supplementing and running numerous fundraisers together can pay off in a big way, and put those money-raising goals within reach.
Pop cans, scrap metal, you name it. People love to get things they have no use for anymore off their hands and into those of people who will use it for good. Make sure instructions are clear for where to drop off items, and that the drives are well-marketed, and you should see success.
The holiday pie, wreath, flower, and cookie season has officially begun! Take advantage of this festive time and tap into your community members. They'll like having the opportunity to support their local marching band while crossing some holiday gifts off the list at the same time.
Even though you're busy with all of your family's fall activities, making time for a community event has the potential to bring in a great deal of funds. A silent auction, cook off, special dinner, or an impromptu holiday concert around town are great community events to raise money and morale for an upcoming band event.
Some fundraisers require no selling, very little marketing, and minimal effort. A scrip program is one of these. Once you learn how easy it is to start a program, band families can begin raising money toward travel fees for that out-of-state festival or competition, just by doing their regular shopping and spending with gift cards!
Set a Goal and Reach It!
Be inspired by this marching band's journey to participating in a once-in-a-lifetime opportunity. By combining scrip fundraising with product fundraising, event fundraising, and corporate donations and sponsorships, they raised $500,000- enough to send them to march in the prestigious Parade of Roses in Pasadena, California. They had a fundraising plan, and everyone, including students, parents, and faculty, were fully on board to see it through.
Whatever fundraising path you choose to take, with hard work and dedication from everyone involved, and with a goal in mind, you can raise the money!
Learn more about the journey to the Parade of Roses by downloading the case study.
Follow our Music Parents board on Pinterest for more noteworthy inspiration.


You go to empty the trash in the kitchen and as you go to lift the bag out of the can, only to find the can and the trashbag are joined in some unholy union of gravity defying logic.
You finally manage to pry them apart from each other. But that is only half of the job.
Now when you try to put a new bag into the can it it like trying to wrestle a herd of run away balloon animals.
Well fear not, there is a solution.
What do you mean we are giving this away for free this week?!?
THIS IS INSANE! Some get my agent on the phone.
The problem is caused by trapped air.
A lack of air between the bag and trashcan when you are trying to remove the bag.
A surplus of air trapped between the bag and the can when you reset it.
Grab you favorite instrument of perforation, It's time to get to work.
By making a series of holes around the bottom of the trash can, there is no longer a lack of air in the can when you try to remove the bag, and you won't have to try to deflate the new trashbag that you put into the can.
I chose to place three holes along the long sides of the can and two on the short sides and that seems to be sufficient ventilation.
By placing the holes about 3 inches from the base of the can, it creates a bit of a catch basin so that if there is any liquid in the trash and the bag happens to leak it will not make a mess on the floor.


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Each one of us loves the ease and convenience that digital marketing offers. We often tend to ignore the efforts that businesses and their teams are putting in. One of the most formidable challenges in the field of digital marketing, for companies and their marketers, is to maintain the pace with the speed of advancements launched. Just give it a thought that if the busy marketing teams won't be able to catch up and miss things due to their involvement in routine activities – how unpleasant would it be for the people who don't belong to this industry?
If you are also a marketer, you might be facing the same issues. The visitors or end-readers could sympathize with you, but that doesn't strictly implies they will stop nagging about the significance of surviving through the constraints of time to stay ahead of rise and falls of digital marketing. Not just a single trick or strategy, staying up-to-date with digital trends and unbeatable practices are the actual driving forces for successful, long-term campaigns of marketing.
We all know that the Internet is an aesthetic space where images, graphics and videos play a prominent role in the stories that marketers and companies narrate. But as the accessibility of web design among masses has increased at a progressive rate, it is changing at a faster pace.
Everyone today has become familiar with the trend of long scrolling; credit goes to the mobile devices. This technique is working really well for the websites that want to win over the users through the medium of storytelling. Moreover, you can try breaking that scroll into sections. So, all the sites that are using sliders should pull up their socks. Even statistics have a clear intimation for them. It has been observed that only 1% of the website visitors stumbled upon a five-feature slider and among them, 89% population proceeded to click on the first image.
The use of sliders was introduced to induce clicks on the most significant features of your site, but they didn't work out. So, it's time for a change and implements new designing features that are simple-to-use.
As the adage goes – 'Content is King'. It is actually the most influential factor for the success of your web design. In a recent survey, 45% of the marketing professionals' written content makes the most of the influence. But there are still many designers who work with dummy content. This is simply not good to go. You should design and write the content side-by-side. Having appropriate content in hands will help you get the right design and you will end up producing a finely-done website.
It's quite simple to get stock images. It is their obviousness that makes them unable to shift the needle as much as the customized images do. There are a plethora of tools available in the market that makes creating customized images easier. Even stats justify the usage of custom images – 46% of marketers agree that customized photography has become an inevitable part of marketing strategies.
Due to the extended accessibility of the stock photos, the ability to custom images to improve engagement has gone more profound while making sites more resourceful. It would be a favor for your own self to quit using stock images or, at least, modifying them a little. It's really worth making some extra effort to get noticed by the maximum potential audience.
No one today is patient enough to wait for a long time just for a website to load. A way too slow website makes browsing an irritating experience. From the statistical point of view, 40% of the people simply abandon the web page if its loading time exceeds three seconds. This is often a reason why sliders are losing their hold.
No longer is the time when you can get the required results with merely fresh content pieces and an active presence in social media channels. Today, you need to identify the perfect medley of marketing tricks so to get success. In fact, 65% of the marketing professionals believe that visually rich content comprising photos, illustrations, videos and Infographics could help brands to tell their story in an effective manner.
All this might sound like a lot's of work, but you will realize the worth of putting so many efforts once you will gain a remarkable recognition in the digital world.
Kristy Bernales is working as a full-time designing professional with Melbourne Web Design Xperts Company. Each blog of hers is a great source of information for both newbies as well as experienced designing professionals. Work feels no less than a pleasure when she is tuned in with her favorite tracks.


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● Love Island star Sophie Gradon took her own life after consuming alcohol and cocaine, inquest hears Love Island star Sophie Gradon took her own life after taking cocaine and drinking alcohol, an inquest has found.
● Chelsea vs Slavia Prague line-ups: Predicted XIs and latest team news for tonight's Europa League clash Chelsea are set to be without Antonio Rudiger for Thursday's Europa League meeting with Slavia Prague.
● Margareta Pagano: Plenty for City to cheer but we must clean up banking The City has every reason to be cheerful. A recent report ranked the UK as the top investment destination in the world, knocking the US off its perch.
● Girl, 16, quizzed by police after pupils fall ill from eating hash cakes at London school Three pupils were taken to hospital after reportedly eating cannabis cakes at a London school.
● Jim Armitage: Time for Alan Jope to go full throttle on Unilever's ethics Unilever's new boss Alan Jope loves danger. That's why he goes motorbiking in the world's most remote places.
● MPs to investigate huge cost of Brexit planning Billions of pounds thrown at preparing Britain for Brexit including a no-deal departure are to be investigated by a powerful group of MPs.


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Batteries for use in vehicle applications must be safe and ideally have high energy densities. Currently, Lithium Ion Batteries are being used for vehicle electrification; however, safety issues and limited potential for increasing energy density (driving range) remain problematic. Unfortunately, increasing energy density through the use of Li-metal anodes or high energy density cathode materials increases safety issues. The development of next generation safe batteries with high energy densities is desired. Anion Shuttle Batteries represent one possible chemistry to achieve good safety with high energy density. Batteries based on anionic charge carriers have the potential to generate multiple electron transfers for a given metallic electrode and eliminate the formation of dangerous metallic dendrites observed in cation based chemistries. Our research goal is to understand the feasibility and practicality of anion shuttle based battery chemistries as they pertain to vehicle applications.


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Ph.D. position (f/m) in Theory and Computation of Coherent Structures
ETH Zürich Zürich (Schweiz) Show on map
The Chair in Nonlinear Dynamics (lead by Prof. G. Haller) at ETH Zürich has an opening for a Ph.D. position in the general area of Theory and Computation of Coherent Structures in Turbulent Flow Data.
Ph.D. position in Theory and Computation of Coherent Structures
The project aims to further develop objective Eulerian and Lagrangian detection algorithms for large coherent structures in stratified turbulence. These stuructures will be located via their boundaries that minimize the transport of some passive scalar (say, a diffusive dye) or some active scalar (say, vorticity or potential vorticity). This effort will join theory, experiments and simulations to develop efficient algorithms for unsteady coherent structure detection in large data sets. Application areas include turbulent flows in engineering devices, in the ocean and in the atmosphere.
The successful candidate has an MSc in engineering, applied mathematics or physics (or equivalent) and has research interest and background in turbulent flows and dynamical systems. She or he has excellent mathematical skills and demonstrated experience with numerical methods. Background in advanced data analysis (image processing, statistical data analysis etc.) is an advantage. The Ph.D. is interested in a scientific career and in interdisciplinary project collaboration and has working knowledge of English. The starting date is negotiable but early starts are preferred. Contract duration is 1 year, renewable multiple times upon satisfactory progress.
We look forward to receiving your online application including a CV, undergraduate and masters transcripts, as well as a motivation letter along with two contacts for reference letters. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
For further information of research at the Chair in Nonlinear Dynamics, visit www.georgehaller.com or contact Prof. Haller at georgehaller@ethz.ch (no applications).
Published on academics on 15 June 2018
Current search terms: Physics, Mathematics, Electrical Engineering, Electronics, Mechanical Engineering, Computer Sciences, Industrial Engineering, PhD Student, Science, Research and Higher Education, IT, Telecommunication, Switzerland, University, Full Time
Berlin Mathematical School (BMS)
The Berlin Mathematical School is a joint graduate program between the mathematics departments at three universities and a part of the Excellence Initiative
Balance of the Microverse
PhD Position (f/m/d) in Electro-Optical-Mechanical Materials and Devices for Energy Harvesting Systems
PhD position in applied mathematics
Bergen (Norwegen)


text:
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Is uber publicly traded company
25 Jun 2019 One indirect method is to invest in a publicly traded company that owns a sizeable share of Uber private stock. Some major Uber investors 10 May 2019 The ride-hailing business (NYSE: UBER), previously valued at $72 billion by venture capitalists, priced its stock at $45 apiece for a valuation of If an emerging growth company, indicate by check mark if the registrant has Since Uber Freight's public launch in the United States in May 2017, we have
10 May 2019 After almost a decade of disruption, Uber is finally going public. The company is the highest valued tech IPO since Facebook and Alibaba, and 9 May 2019 Uber will go public on Friday in a highly anticipated initial public offering that will be the largest since 2014 — and one of the biggest in U.S. 10 May 2019 Uber is now the second ride-hailing company to hit the U.S. public market, following Lyft's debut in March. Both companies have been heavily 30 May 2019 SAN FRANCISCO — Uber's start as a publicly traded company has gone from bumpy to bumpier. In its first earnings report since listing its
25 Jun 2019 One indirect method is to invest in a publicly traded company that owns a sizeable share of Uber private stock. Some major Uber investors
By most measures, Uber is much bigger and has a more diverse revenue stream. It is the world's biggest ride-sharing company, with operations in 63 countries. Its revenue comes not just from ride-sharing but from Uber Eats, its food delivery business, as well as from its trucking business and bike and scooter sharing. The 2019 Uber IPO Is Less Attractive Every Day Uber's new CEO has been prepping for the 2019 IPO, but it's not the belle of the ball any more. era behind the company. He's publicly set 2019 Uber already operates a self-driving car program in the state, and back in 2015, partnered with the University of Arizona to research mapping technology. Uber also recently acquired car start-up Otto, which specializes in self-driving trucks. Otto is a 90-person company, and its co-founder, But here's the thing: Uber shares are not publicly traded. The California pension fund that filed the class action does not own Uber stock outright. It owns shares of a Morgan Stanley-managed investment vehicle that, in turn, owns Uber shares. Uber Technologies Inc. is not publicly traded, and therefore not obliged to disclose its financial performance, but it organizes a quarterly conference call with some investors. These include some big names in the world of finance, such as Goldman Sachs Group Inc (NYSE:GS).
10 May 2019 Uber raised over $8 billion in its first day as a publicly traded The company opened its first day of trading with an initial public offering price of
24 May 2019 Uber is now a massive, publicly traded company. Anyone can buy Uber shares at a valuation of about $70 billion. This isn't bad for a company 10 Apr 2019 Uber could finally start going public on Thursday--and the company hopes to achieve one of the biggest tech IPOs in history. The ridesharing 10 May 2019 The company's new, soft-spoken CEO, who previously ran Expedia, has stabilized the company enough to bring it to the public markets, although 10 May 2019 Uber dropped 7 percent in trading on Friday in the ride-hailing service's first day as a publicly traded company. The corporation priced its initial 11 May 2019 On Thursday, May 9, Uber entered the New York Stock Exchange as a public company by setting an IPO of $45 per share. Although the 9 May 2019 As of this Friday, May 10, ride-hailing service UBER is going public, to a publicly-traded company, by placing its shares somewhere in the 17 May 2019 2 US ride-hailing company was 27 million shares, or 82 per cent of the Lyft and Uber lose lots of money, which has unnerved public market
The 2019 Uber IPO Is Less Attractive Every Day Uber's new CEO has been prepping for the 2019 IPO, but it's not the belle of the ball any more. era behind the company. He's publicly set 2019
9 May 2019 Uber will go public on Friday in a highly anticipated initial public offering that will be the largest since 2014 — and one of the biggest in U.S. 10 May 2019 Uber is now the second ride-hailing company to hit the U.S. public market, following Lyft's debut in March. Both companies have been heavily 30 May 2019 SAN FRANCISCO — Uber's start as a publicly traded company has gone from bumpy to bumpier. In its first earnings report since listing its 10 May 2019 Uber raised over $8 billion in its first day as a publicly traded The company opened its first day of trading with an initial public offering price of 10 May 2019 Uber's agonizingly difficult first day as a public company was a cold shower for Silicon Valley's hottest company, a dousing that drenches both
Uber filed documents with the Securities and Exchange Commission to become a public company Thursday, in what is expected to be one of the biggest tech IPOs in history. The company said it lost $10 billion since 2016, underscoring the precarious nature of Uber's business.
10 May 2019 Uber dropped 7 percent in trading on Friday in the ride-hailing service's first day as a publicly traded company. The corporation priced its initial 11 May 2019 On Thursday, May 9, Uber entered the New York Stock Exchange as a public company by setting an IPO of $45 per share. Although the 9 May 2019 As of this Friday, May 10, ride-hailing service UBER is going public, to a publicly-traded company, by placing its shares somewhere in the 17 May 2019 2 US ride-hailing company was 27 million shares, or 82 per cent of the Lyft and Uber lose lots of money, which has unnerved public market 10 May 2019 As Uber prepares to list on the New York Stock Exchange investors are asking: Can Uber ever be profitable? The company has posted only 28 Mar 2019 Ride-hailing service Lyft is set to become a publicly traded company on Friday, in a highly anticipated IPO. Here's what you need to know. 18 Mar 2019 An initial public offering (or IPO) is when a company first sells its shares for purchase on public stock exchanges. After an IPO, the company is
15 Feb 2019 Uber Technologies and Lyft Inc., both planning highly-anticipated public Since no ridesharing company has yet been tested in the public Before Uber Is Publicly Traded, Major Changes Need to Happen. Since the start of 2017, Uber has been marked by scandals, some of which include: Feb. 19: Susan Fowler, a former engineer for the company, alleged in a blog post that she was sexually harassed while at Uber. After a forgettable first nine months as a publicly traded company, is Uber finally ready to live up to the lofty expectations? Prosper Junior Bakiny (TMFPBakiny) Uber Technologies, Inc., commonly known as Uber, is an American multinational ride-hailing company offering services that include peer-to-peer ridesharing, ride service hailing, food delivery, and a micromobility system with electric bikes and scooters. The company is based in San Francisco and has operations in over 785 metropolitan areas worldwide. Its platforms can be accessed via its websites and mobile apps. As of 2019, Uber is estimated to have over 110 million worldwide users. In the Unit Uber IPO has been finally announced on Thursday, May 9 th. and became a publicly traded company, alongside the fact that Uber has become the second name for ridesharing. At the opening sale, Uber started at the price of 45$, soon going down below the initial price and touching 41$ per share at the closing. Uber filed documents with the Securities and Exchange Commission to become a public company Thursday, in what is expected to be one of the biggest tech IPOs in history. The company said it lost $10 billion since 2016, underscoring the precarious nature of Uber's business. The Indirect Approach. One indirect method is to invest in a publicly traded company that owns a sizeable share of Uber private stock. Some major Uber investors include Alphabet Inc. (GOOG), Microsoft Corp. (MSFT), Softbank (which can be bought OTC, the ticker is SFTBY), or private equity giant BlackRock Inc. (BLK).
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Perspective Of An Average Steelers Fan: End Of Year Rookie Review
By David Orochena
Posted on January 6, 2020 at 10:30 am
Top 3 Rookie Draft Picks
It's a Sunday with no Pittsburgh Steelers football today. Appropriate time to update the review of the Steelers top three picks from the 2019 draft. The midseason review gauged the progress of Devin Bush, Diontae Johnson, and Justin Layne against their counterparts in the draft.
Here is the link to the midseason rookie tale of the tape if you want to compare the statistical change from the season's midpoint.
Here is how the Steelers first three 2019 draft picks stack up statistically against their contemporaries after one regular season of play:
Name G Snaps Snap% INTs PDs FF FR Sacks Tackles TFL/QBH
Devin Bush 16 892 82 2 4 1 4 1 109 9/2
Devin White 13 826 73 1 3 3 4 2.5 91 4/5
Josh Allen 16 634 60 0 0 2 0 10.5 44 11/22
Rashan Gary 16 244 24 0 0 0 1 2 21 3/3
Jahlani Tavai 15 597 52 1 2 1 0 2 57 5/3
Ben Banogu 16 271 26 0 1 1 0 2.5 11 3/5
Mack Wilson 16 944 88 1 7 1 0 1 81 4/2
All statistics pulled from the Pro Football Reference
Synopsis of each player through preseason:
Devin Bush (1st/10th overall) Devin Bush put together a fine rookie campaign. His six takeaways led this linebacker group. However, all six were in the first half of the season. He did lead this group in tackles with 109. If Bush had continued the pace he set in the first half, he would be a shoo-in for defensive rookie of the year. Regardless, his strong season bodes well for next season.
Devin White (1st/5th overall) The Tampa Bay Buccaneers linebacker came on extraordinarily strong after missing three games due to a knee injury. He scored two defensive touchdowns and recorded 91 tackles second to Bush. White is disruptive as evinced by his interception, three forced fumbles and four fumble recoveries.
Josh Allen (1st/7th overall) The Jacksonville Jaguars have a legitimate contender for rookie of the year. Josh Allen sacked quarterbacks 10.5 times. His 44 total tackles included 11 for a loss. He also hit the quarterback 22 times. His 10.5 sacks and 22 quarterback hits are way ahead of the other LB's in this group. Allen compares favorably to San Francisco 49ers rookie of the year candidate Nick Bosa. One significant difference is Bosa is playing in the playoffs while Allen will be watching from home.
Rashan Gary (1st/12th overall) The Green Bay Packer played in all 16 of their games but only 24% of their defensive snaps. However, he has an opportunity to showcase his talent in the playoffs. He wore a brace all season to protect his labrum that he tore during his senior year at Michigan. For a top 12 pick, I expect the Packers are looking for more production.
Jahlani Tavai (2nd/43rd overall) Tavai played half of the Detroit Lions defensive snaps in 15 games. He recorded a sack in his first game and intercepted a pass in week 15. He finished the season with 57 tackles including five for a loss and three quarterback hits. However, he hurt his shoulder and missed the last game of the season.
Ben Banogu (2nd/49th overall) The Indianapolis Colts linebacker played in all 16 games but limited to 26% of the Colts defensive snaps. He played as a defensive end or edge defender and the Colts like his ability to rush the passer.
Mack Wilson (5th/155th overall) Steelers Depot respondent Beeze requested Wilson's inclusion. The Cleveland Browns started Wilson in every game starting in week 3. His 944 snaps and seven passes defensed led this group of linebackers. He ranks third in the group with 81 tackles and intercepted a pass. If Wilson continues to progress and remains a regular starter, the Browns have found themselves a bargain.
Linebacker Summary
Few linebackers were selected in the first two rounds, so Devin Bush may be compared to some rookies playing on the edge. Bush remains at the top of his class. Devin White played extraordinarily strong in the second half of the season. It will be fun to see how they two stack up with one another over the next few seasons. Josh Allen is playing as a defensive lineman. He had a strong season with his 10.5 sacks and should be a candidate for rookie of the year. Mack Wilson is the bargain of this group. A productive starter selected in the fifth round.
Name G Snaps Snap% RECs Yds Y/C Y/G Catch % TDs
Diontae Johnson 16 654 66 59 680 11.5 42.5 64.1 6
Deebo Samuel 15 709 67 57 802 14.1 53.5 70.4 6
A.J. Brown 16 678 68 52 1051 20.2 65.7 61.9 9
Mecole Hardman 16 471 45 26 538 20.7 33.6 63.4 6
JJ Arcega-Whiteside 16 486 42 10 169 16.9 10.6 45.5 1
Parris Campbell 7 196 18 18 127 7.1 18.1 75.0 1
Andy Isabella 15 157 15 9 189 21.0 12.6 69.2 1
D.K. Metcalf 16 927 84 58 900 15.5 56.3 58.0 7
Jalen Hurd 0 0 0 0 0 0 0 0 0
Terry McLaurin 14 767 82 58 919 15.8 65.6 62.4 7
Marquise Brown 14 563 51 46 584 12.7 41.7 64.8 7
Diontae Johnson (3rd/66th overall) Diontae led this group in receptions with 59. However, his yards per reception is one of the lowest. He scored five touchdowns in the air and added a punt return score. Johnson became a regular punt returner in addition to his receiving duties in the second half of the season. He led the NFL with 12.4 yards per punt return.
Deebo Samuel (2nd/36th overall) The San Francisco 49ers used Deebo in a variety of roles. He scored three touchdowns in the air and three on the ground. He caught over 70% of passes targeted to him which is second among the group. While not tops in any one area, Samuel is near the top in snaps played, receptions, receiving yards, scoring, and receiving yards per game. Let's see how he performs in the playoffs.
A.J. Brown (2nd/51st overall) The rookie Tennessee Titan led this receiver group with 1051 receiving yards and averaged 65.7 receiving yards per game. He scored nine touchdowns including one on the ground. His 20.2 yards a reception ranked second in the NFL. He had the third longest touchdown reception in the league at 91 yards. While Brown only caught one pass for four yards in the wild card game, the Titans are moving to the next round.
Mecole Hardman (2nd/56th overall) Hardman caught 26 passes averaging 20.7 yards per catch. He scored six receiving touchdowns which would be a score every 4.3 receptions. The Kansas City Chiefs also use him as a kick returner. He averaged 26.1 yards a return adding a seventh touchdown on a kick return. Hardman beat out Diontae Johnson as the AFC Pro Bowl return specialist. He will be in the playing in the playoffs.
JJ Arcega-Whiteside (2nd/57th overall) Arcega-Whiteside had only 22 passes targeted to him despite playing in all 16 games. He does have a foot injury but continues to be active. The Philadelphia Eagles are in the playoffs and we will see if he plays a significant role.
Parris Campbell (2nd/59th overall) Campbell appeared in seven games and caught 18 passes for 127 yards and one touchdown. However, the Colts placed him on injured reserve near the end of the season. He suffered a series of injuries including a hamstring injury in the preseason, and a hernia, broken hand, and foot in three separates games during the regular season. He caught 75% of passes targeted to him which led this receiver's group.
Andy Isabella (2nd/62nd overall) Isabella appeared in 15 games but played just 15% of the Arizona Cardinals offensive snaps. He caught nine of 13 passes targeted to him. He did score an 88-yard touchdown in week 9 that helped bulk up his 15.6 yards after catch per reception stat. The Cardinals sixth round pick had 21 receptions. It is too early to say the Cardinals missed on this pick. Let's see what he does in 2020.
DK Metcalf (2nd/64th overall) Seattle Seahawks Metcalf leads the group in snaps. Also, he's second in receptions with 58 and third in receiving yards. His seven touchdowns are among the group's leaders. He does have a 7.0% drop rate per target. We will see how he performs in the playoffs.
Jalen Hurd (3rd/67th overall) The 49ers Jalen Hurd is on injured reserve due to a back injury and did not play this season.
Terry McLaurin (3rd/76th overall) The Washington Redskins have found a wide receiver. McLaurin recorded three 100-yard games out of 14 played. He scored seven touchdowns. Within this group of receivers, he ranked second in receptions, receiving yards, and receiving yards per game. He did drop 4.3% of passes targeted to him.
Wide Receiver Summary
I am comparing Diontae Johnson to wide receivers selected in the 2nd and 3rd rounds. So, I do not include Marquise Brown though I did add a stat line for him. In my view, A.J. Brown ends up at the top of this heap. D.K. Metcalf and Deebo Samuel are not far behind. McLaurin who led at the midpoint faded as the season wore on but still had a strong rookie performance. Diontae Johnson is right up with the leaders but has room to improve. Perhaps a year with one quarterback will help as it will McLaurin.
Justin Layne 10 0 0.00 0 0 0 0 0 0 0/0
Deandre Baker 16 971 87 0 8 0 0 0 61 2/0
Byron Murphy 16 1105 98 1 10 0 0 0 78 3/0
Rock Ya-Sin 15 852 82 1 5 0 1 0 61 2/0
Sean Murphy-Bunting 16 686 61 3 8 1 0 1 43 1/0
Trayvon Mullen 16 678 65 1 10 0 0 0 48 0/0
Joejuan Williams 9 80 8 0 1 0 0 0 4 0/0
Greedy Williams 12 686 64 0 2 0 0 0 47 2/0
Lonnie Johnson 14 530 49 0 7 0 0 0 38 0/0
David Long 14 67 6 0 1 1 0 0 12 2/0
Jamel Dean 13 370 33 2 17 0 0 0 21 1/0
Justin Layne (3rd/83rd overall) The Steelers did not play Layne in a single defensive snap. He did play 91 special team snaps in his ten appearances. Artie Burns was the back-up cornerback that received defensive snaps when injury or other circumstances necessitated the move. However, Mike Tomlin activated Layne was over Burns in the latter half of the season. We will have to wait the next season or two to see if Layne measures up to his contemporaries all of whom got a head start on him.
Deandre Baker (1st/30th overall) Baker started 15 of 16 games and played in 87% of the New York Giants defensive snaps. He has had an uneven season getting beat on several passes that have gone for touchdowns. Baker did defense eight passes while quarterbacks targeted him 87 times. He allowed 54 completions for a 62.1 completion percentage. Quarterbacks received a 116.5 quarterback rating when throwing in his direction.
Byron Murphy (2nd/33rd overall) Byron Murphy was a starter out of the gate and ended up starting all 16 Arizona Cardinals games playing 98% of their defensive snaps. His ten passes defensed ties for second among the rookie cornerbacks. Murphy has 78 tackles with nine misses for a 10.3 missed tackle percentage. Opponents tested his coverage skills. Quarterbacks targeted him 112 times and he allowed 78 completions for a 69.6 completion percentage. Quarterbacks enjoyed a 110.5 quarterback rating when targeting him.
Rock Ya-Sin (2nd/34rd overall) The Colts started Rock in 13 of the 15 games he played. He played more defensive snaps than any other Colt defender this season. He made 61 tackles with just four misses for a low 6.2 missed tackle percentage. Opposing quarterbacks targeted him 66 times and he allowed 46 completions for a 69.7% completion percentage. Opposing quarterbacks averaged a 109.2 rating when targeting him so coverage is an area to work on.
Sean Murphy-Bunting (2nd/39th overall) The Tampa Bay Buccaneers used Murphy-Bunting sparingly in the first half of the season. They he started the last nine games of the season. He led this group with three interceptions including a 70-yard pick-six. Passers targeted him 60 times allowing 39 completions for a 65% completion average. However, quarterbacks only earned an 86.6 quarterback rating when they threw passes his way. His missed ten tackles while recording 43 for an extremely high 18.9% missed tackle percentage. Tampa Bay must be pleased to score two defensive backs in the draft.
Trayvon Mullen (2nd/40th overall) The Oakland Raiders played Mullen in 65% of their defensive snaps. He was targeted 68 times but gave up just 38 completions for a 55.9 average. Mullen defensed ten passes and had an interception. He started the Raiders last ten games and will be a key piece of their secondary in Las Vegas.
Joejuan Williams (2nd/45th overall) The New England Patriots began using Joejuan more as their secondary became depleted. But, he only played 80 defensive and 84 special team snaps during the regular season. He may figure more into the Patriots plans in 2020.
Greedy Williams (2nd/46th overall) The Cleveland Browns got Greedy to play 12 games this season. One area he requires improvement is tackling. He had eight misses for a 14.5% missed tackle average. Greedy has a lot of talent on defense and he could be a contributor if he stays healthy.
Lonnie Johnson (3rd/54th overall) The Houston Texans rookie played about half of the defensive snaps. He started seven games, but the Texans acquired two former first round draft picks. Their reinforced secondary allows Johnson to fill in as a reserve as he learns the ropes. Johnson missed eight tackles for a high 17.4 missed tackles percentage. He defensed seven passes and made 38 tackles in 530 snaps.
David Long (3rd/79th overall) The Los Angeles Rams did not play Long much in 2019. The rookie played just 67 defensive snaps in eight games played. He did allow quarterbacks a 117.5 rating on passes targeting his receiver. Not much to report until he gets more playing time.
Jamel Dean (3rd/94th overall) Injuries hampered Dean's progress with the Buccaneers limiting him to three defensive snaps in the first half of the season. However, he finished strong starting five of the last six games. He led all the rookies with 17 passes defensed plus two interceptions while playing one third of Tampa Bay's defensive snaps.
Cornerback Summary
The long NFL season is a test for any rookie especially defensive backs. Sean Murphy-Bunting gets the nod as the top rookie cornerback. This is mostly due to the low quarterback rating he enforced plus three interceptions. The Cardinal's Byron Murphy, New York Giant Deandre Baker and the Colts Rock Ya-Sin round out the top. However, Jamel Dean came on extraordinarily strong with his 17 passes defensed. Justin Layne has a long way to go to catch up with a strong group of cornerbacks.
The Steelers got significant contributions from two of their three top 2019 draft picks. A good start. Good enough for Pro Football Focus (PFF) to rank the Steelers 2019 NFL draft class as the fifth best in the league. Matt Marczi covered this Sunday morning. Still, it will take a few seasons to find out if these players continue on an upward trajectory. Here we go!
Your Music Selection
I always like to include a bit of music. Here is Sunday Bloody Sunday by U2.
Related Items:Devin Bush, Diontae Johnson, Justin Layne, Pittsburgh Steelers
Becoming Less Predictable Tops Pat Freiermuth's 2022 Goals
Listen: The Terrible Take (Episode 320)
Steelers Sign 12 Players To Futures Contracts Tuesday


text:
Filtered by: Anime & Manga, Arts & Entertainment, History, LGBT, Museums, Neighborhoods, Nightlife, Shrines & Temples, Traditional, Zoos & Aquariums
Specialities Nightlife - Osaka's retro-yet-modern vibe gives it the feel of a cult 80s movie set in the future. Images of the kaleidoscope of neon that lines Dotonbori...
Specialities Shrines & Temples - Japan's capital for more than 1000 years, the story of an ancient nation is written all over Kyoto's cobbled streets, endless temples and gardens, and...
Specialities Neighborhoods, Nightlife - Roppongi is a district in the Minato ward of Tokyo. It's post-war reputation as a somewhat seedy entertainment district popular among foreigners has h...
Gion
Specialities Traditional - The original Japanese pleasure quarter, Gion is Kyoto condensed into a scene straight out of Memoirs of a Geisha. This is where you might just...


Excitement mixed with awe, like in the early days, when they first set out to explore Nekhuan and she could not help feeling out of place, for what business did they have to spoil the peace of a planet that had existed undisturbed since the dawn of time? Not that she doubted their mission, the need to find a new habitat for mankind was unquestionable and, some said, quite urgent. Still, every step that crushed a even single blade of grass felt like a terrible act of intrusion against this planet, wild and teeming with life, like Earth must have been before man first walked upright.
Wandering away from the foot of the hill, making her way through the sparse underbrush, Sarah wondered if she was going crazy, like Bercow. The voices she thought she heard could not be real, all the surveys, before and after landing were clear, there were no signs of any sort of civilization on Nekhuan. And yet.
She did not dare make her way to the heart of the forest on the other side, she kept close to the edge, the metal transmission tower always in sight. A little red bird, perched high up on a tree was watching her with indifference, making Sarah feel even more like an intruder, although after almost one year on Nekhuan they'd started feeling at home. They'd earned their right to be here, she argue with herself, working hard to build a home for themselves and growing their own food. Not all, but enough to make them confident the project was working.
As she was made her way round the hill, something caught her eye. Hidden behind a dense thicket, the tall grass gave way to a patch of brown soil, completely barren. An unnatural rectangular shape that seemed to mark the door of hobbit's dwelling. Could be nothing, she thought, maybe just a big boulder buried in the side of the hill, but the biologist's critical mind was overruled by simple human curiosity. She had to check. Her small shovel had not trouble digging at the soft dirt, that crumbled and fell away to reveal some sort of metal shield, gray and scratched as if it had been carried over a rough terrain. The notion that she should alert her colleagues was swiftly discarded. It was her right to discover what lay beneath, if anything. She wedged the tip of her shovel on the right side to pry the cover open, but what she found was nowhere near as impressive as she was hoping. It was not the secret entrance to an underground tunnel, nor the hiding place of the creatures that howled in the night, not even a hobbit's house. Just a hole in the earth barely big enough for her to fit inside. Empty. Or almost empty, for there was something lying on the ground. An oblong object no bigger than her flashlight and covered in dust. When she managed to clean it up a bit by rubbing it on the leg of her jeans the object was revealed to be transparent, as if made of glass, but softer to the touch. A material she'd never seen before. Weird black worms were trapped inside, yet clearly alive, moving around quickly, weaving and unweaving strange patterns. Strange, but somehow familiar. It did not take long for Sarah to realize where she'd seen those patterns before, John Bercow's scribbles. She dropped the thing as if it had suddenly turned red hot, but it did not break and the black lines went about their squiggly dance undisturbed.
The already long hours Sarah spent doing research became even longer. Her door latched against intruders, the young woman stared at the black lines which she decided were not worms or living creatures of any kind. It was more like ink and, whatever its origin, the device carried a message. The patterns were not random and repeated endlessly. It was hard to make any sense for they kept changing rapidly, to quick for her to sketch on a piece of paper. Her attempts to copy any pattern ended in frustration, as some were quite similar and she could never be sure if it was the same one. Three exhausting nights were wasted with the painstaking attempts to manually capture the images, until she realized the obvious solution. Take pictures and load them on her computer. In less than two hours she had a folder with 293 different squiggly signs she could study at will.
Sarah felt like that guy, whatever his name was, who deciphered the Egyptian hieroglyphs, only her work was even harder. The hieroglyphs were easier to translate as they had been made by human beings and many of the signs referred to easily recognizable earthly things, whereas she had no idea who had left the message buried in the hole.
Little by little, the images on the screen started to make sense. She felt sure the sign that looked like a Z in reverse with a little pointy hat on top of it referred to an alien being. If these were the inhabitants of Nekhuan what had happened to them?


text:
El año 198 a. C. fue un año del calendario romano prejuliano. En el Imperio romano, fue conocido como el año 556 Ab Urbe condita.

Acontecimientos

Por lugar

República romana
 Después de su elección para el consulado, Tito Quincio Flaminino es elegido para reemplazar a Publio Sulpicio Galba Máximo como el líder general romano en Macedonia. Entonces cruza a Macedonia con su ejército. Flaminino se da cuenta de que la paz futura depende de romper el poder del rey Filipo V de Macedonia, no meramente humillándolo. Asegura el respaldo de la Liga Aquea y luego abre negociaciones de paz con Filipo en Nicea en Lócrida. Aunque las propuestas de paz son sometidas al Senado romano, se rompen las negociaciones y se reanuda la lucha.
 Las fuerzas de Tito Quincio Flaminino consiguen sacar a Filipo V fuera de la mayor parte de Grecia, excepto unas pocas fortalezas. Derrota luego a Filipo V en la Batalla del Aoo, cerca de la moderna Tepelenë (en Albania).

Imperio seléucida
 Las tropas seléucidas al mando de Antíoco III derrotan al ejército ptolemaico en la batalla de Panion liderado por Scopas de Etolia. La victoria le permite a Antíoco III obtener el dominio de Palestina, antes territorio del reino Ptolemaico. Aunque los romanos envían embajadores a Ptolomeo V, son incapaces de darle ninguna asistencia contra Antíoco III.
 En la paz resultante, Antíoco III está de acuerdo en dar a su hija Cleopatra en matrimonio a Ptolomeo V.

198 a. C.


text:
All Film, All TV, Horror
Top 10 Horror Films/TV Shows to Watch in 2020
Sommerleigh Pollonais – Senior Writer
Happy New Year ya filthy animals!
Now that we've gotten that out of the way, a new year to most people means new goals, new opportunities and, if you're like me, new and possibly amazing genre content to experience. It's like being a kid at Disneyland, excited for all the wonderful sights and sounds that are about to come my way.
Like my list of Best Horror Movies of the Decade, this list will also comprise of ten of my favourites. But don't worry, I know your time is precious so I promise to keep it short and sweet, and we'll be back to Top 5's again before you know it. Damn these short attention spans!
Let's take a look at my Top 10 Horror Movies/TV Shows to Watch in 2020:
#10 THE NEW MUTANTS
Poor Maisie just watched the Game of Thrones series finale
Maybe it's fitting that this movie has been through development hell, considering the genre it fits in. This movie was made in 2014 and has been cancelled and restarted more than Futurama. For those non-comic book readers out there, The New Mutants are a group of teenaged mutant super-heroes, with powers that lean more towards the supernatural that the scientific. With characters like Karma, who could mentally possess other's bodies, Wolfsbane who could, you guessed it, transform into a werewolf, and Magik, who could, well I think you get the drift.
The comics dealt with a lot of mysticism and the darker tone fits well in the horror genre. So here's hoping all the extra time and effort put into this film gives us a Marvel-based horror movie that's a huge success. Because as someone who loves comics and horror, I can tell you there's a deep well of goodies to be found in Marvel horror comics and comics in general.
Alas, Swamp Thing, we hardly even knew ye.
#9 THE COLLECTED
You sure that mask isn't on too tight? It seems like it's on too tight
I honestly thought it would never happen, but boy am I glad to be wrong! The Collected is the third and final film in the vastly underrated The Collector series.
I mentioned this movie in my Top 5 Scariest Home Invasion movies and it's in my opinion, a much more enjoyable and well executed version of the death trap-centric Saw films and after the ending we got with Part 2 of The Collector (The Collection) I can't wait to see the levels of craziness director Marcus Dunstan and his team has in store for us.
#8 CREEPSHOW (TV SHOW)
Dang Lauren! I bought you three face creams for Christmas. Please use them
Even the most faithful of genre fans can miss out on some good stuff once in a while. I'm only human people! But as they say, better late than never. Creepshow is based off of the anthology movies that came out in the 80's and I recently caught up with the six episodes of Season 1.
Picture Homer Simpson looking at a box of doughnuts and you'll know exactly how I felt watching these. Seriously, it's a horror fan's dream with the talent of icons like Joe Hill, Stephen King and Greg Nicotero (special effects guru behind Day of the Dead, Sin City, Ginger Snaps etc.) just to name a few involved with the tales being told.
Do yourself a big favor and catch up on this one before Season 2 drops. You won't be sorry.
#7 LOVECRAFT COUNTRY (TV SHOW)
Worst…BBQ…ever!
Once again Jordan Peele takes on the horrific side of racism with the upcoming Lovecraft Country. Based on the novel of the same name and following a family who not only has to survive the racist terrors of Jim Crow America, but the horrific monsters from the mind of H.P. Lovecraft himself.
The talent behind this upcoming series is any horror fan's wet dream, with both Peele's Monkeypaw Productions and J.J. Abrams Bad Robot Productions in the mix. And if that's not enough to get you on board, it's an HBO series.
They had me a H.
#6 CANDYMAN
Say my name, say my name, if no is around you…
I wonder if I say his name five times if he'll appear, and I'm not talking about the man with the hook.
Jordan Peele goes into remake mode and brings back a fear of saying names repeatedly to a new audience with his re-telling of Candyman. Bringing back the man with the honeyed voice, Tony Todd alongside Yahya Abdul-Mateen II (Watchmen TV series/Aquaman), Teyonah Parris and a slew of other talented folks to bring one of horrors most iconic villains back to life.
With the strong remakes we've been getting recently in horror, like Halloween and Child's Play, now is the perfect time to bring Sweets to the Sweet and I can't wait to see what Peele does with this one.
#5 HALLOWEEN KILLS
Five dollars to wash your windshield?
Speaking of Halloween, Seth Rogen and David Gordon Green did the near impossible in 2018 when they course-corrected this franchise and made Michael Myers fun to watch again. There were those who thought this was gonna be the final showdown between Jamie Lee Curtis aka Laurie Strode and her guy who just won't take the hint.
Halloween Kills was originally intended to be shot back to back with Halloween, but they wanted to see how fans would react to the first film.
Needless to say, we friggin' loved it so get ready for the Lord of the Rings, except with less hobbits and more stabbing as Halloween Kills will be followed by Halloween Ends in 2021.
Halloween Ends…..yeah right.
#4 PENNY DREADFUL: CITY OF ANGELS (TV SHOW)
Wow. You look nothing like your Tinder profile pic
It breaks my horror-loving heart more people didn't watch Penny Dreadful, but ask any of us who did and we can tell you it was gothic horror at its best.
Giving us beautifully haunting and fully fleshed-out versions of Dracula, Frankenstein, The Wolfman and a bunch of other classic monster tales, Penny Dreadful was that series I loved from beginning to…okay, I didn't like the finale but it was still damn good!
Now we get to visit that macabre world all over again and this time taking a page from another successful series, American Horror Story, by telling a whole new tale with new characters. City of Angels will star the gorgeous perfection that is Natalie Dormer and the story will center on Mexican American folklore.
Excuse me while I go re-watch this series as I wait with baited breath for City of Angels.
#3 THE INVISIBLE MAN
And then the Invisible Man flushed the toilet…
You just know Warner Bros is kicking themselves that they couldn't get their Dark Universe of the ground, yet here comes Leigh Whannell (Saw, Insidious, Upgrade) with his take on The Invisible Man and after that trailer, it's all anyone is talking about. So much so, they cancelled the version they had coming with Johnny "I really need to stop for a while" Depp.
Equal parts psychological and science fiction horror, this Invisible Man ironically is the one to watch (get it? Watch? You get it) and with Elisabeth Moss (The Handmaid's Tale) in the main starring role, you just know we're gonna get something real good!
#2 THE HAUNTING OF BLY MANOR (TV SHOW)
AirBnB strikes again!
Do you know there are over thirty hidden ghosts in The Haunting of Hill House!?
Not only is the main story riveting and terrifying to watch unfold, but then you find out there are dead people everywhere and it makes you re-watch this excellent adaptation by one of my personal favorite directors Mike Flanagan. And as you spot them, you scare yourself s&*tless all over again!
I honestly did this and I can tell you, I don't recommend watching this before bedtime. Unless lying in bed trying not to blink as you tell yourself there's nothing in the corner of your room is your thing. Then, have at it you weirdo.
HONORABLE MENTION: DRACULA (TV SHOW)
Bleh! Bleh! Bleh!
First let me say, I saw the trailer for this and I was doing a little jig while watching. It's been SO LONG since the man with the fangs was scary and BBC's Dracula looks to take him back to his Bram Stoker roots, one of the last times Old Fangs was done right.
The only reason it doesn't make my main list is I've been bitten one too many times (what?!) and I may need to spend some time with this version of Vlad before I decide to hand my immortal soul over.
Or at least one day of binge watching, whichever comes first.
#1 LOCKE AND KEY (TV SHOW)
These youngsters and their piercings
You know those movies where that one guy goes into a monologue of waiting centuries for the coming of…whatever? That's me and this series guys!
Locke and Key is based off a series of graphic novels by the prince of horror, Joe Hill (his dad being the 'King' of course ;)) and tells the tale of three siblings who move into their ancestral home after their dad is murdered, only to find the house has magical keys that give them an array of powerful abilities. It sounds like fantasy stuff, but trust me, things get bloody, they get gruesome and the supernatural stuff will make The Haunting of Hill House look like a trip to Disneyland.
To say I'm excited about this series that has changed hands and been stuck in development since 2010 is an understatement. All I'm hoping for now is it lives up to the perfection of horror that is the series of books.
In the immortal words of Mr. Poopybutthole, OOOOHHHWEEE! 2020 looks to keep the train of great horror material coming as 2019 was a high note for this genre fan, so if you already have your list of resolutions done, do me a favor and add one more:
WATCH MORE HORROR! And have yourselves a safe, prosperous and happy 2020 folks!
For my Top 5 Netflix Horror TV Shows you can click here.
Sommerleigh of the House Pollonais. First of Her Name. Sushi Lover, Queen of Horror Movies, Comic Books and Binge Watching Netflix. Mother of two beautiful black cats named Vader and Kylo. I think eating Popcorn at the movies should be mandatory, PS4 makes the best games ever and I'll be talking about movies until the zombie apoclaypse comes. Double Tap Baby!
You can follow me on Facebook and watch my movie review videos on YouTube.
CandymanCreepshow TV ShowDracula BBC seriesHalloween KillsLocke and KeyLovecraft CountryPenny Dreadful: City if AngelsThe CollectedThe Haunting of Bly ManorThe Invisible ManThe New Mutants
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text:
Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish
Carolina Aquilino, Aitor G. Granja, Rosario Castro, Tiehui Wang, Beatriz Abos, David Parra, Christopher J. Secombes, Carolina Tafalla
Marine Alliance for Science and Technology for Scotland (MASTS)
Scottish Fish Immunology Research Centre
CK9 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to mammalian CCL25. Although CK9 is known to be transcriptionally regulated in response to inflammation particularly in mucosal tissues, its functionality has never been revealed. In the current work, we have demonstrated that CK9 is chemoattractant for antigen presenting cells (APCs) expressing major histocompatibility complex class II (MHC II) on the cell surface. Among these APCs, CK9 has a strong chemotactic capacity for both B cells (IgM+ and IgT+) and macrophages. Along with its chemotactic capacities, CK9 modulated the MHC II turnover of B lymphocytes and up-regulated the phagocytic capacity of both IgM+ cells and macrophages. Although CK9 had no lymphoproliferative effects, it increased the survival of IgT+ lymphocytes. Furthermore, we have established that the chemoattractant capacity of CK9 is strongly increased after pre-incubation of leukocytes with a T-independent antigen, whereas B cell receptor (BCR) cross-linking strongly abrogated their capacity to migrate to CK9, indicating that CK9 preferentially attracts B cells at the steady state or under BCR-independent stimulation. These results point to CK9 being a key regulator of B lymphocyte trafficking in rainbow trout, able to modulate innate functions of teleost B lymphocytes and macrophages.
https://doi.org/10.18632/oncotarget.8163
Antigen-Presenting Cells
Chemotactic Factors
Major Histocompatibility Complex
Immunoglobulin M
T Independent Antigens
CC Chemokines
Mucous Membrane
rainbow trout oncorhynchus mykiss
CCL25
Immunology and Microbiology Section
Aquilino, C., Granja, A. G., Castro, R., Wang, T., Abos, B., Parra, D., ... Tafalla, C. (2016). Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish. Oncotarget, 7(14), 17547-17564. https://doi.org/10.18632/oncotarget.8163
Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish. / Aquilino, Carolina; Granja, Aitor G.; Castro, Rosario; Wang, Tiehui; Abos, Beatriz; Parra, David; Secombes, Christopher J.; Tafalla, Carolina.
In: Oncotarget, Vol. 7, No. 14, 17.03.2016, p. 17547-17564.
Aquilino, C, Granja, AG, Castro, R, Wang, T, Abos, B, Parra, D, Secombes, CJ & Tafalla, C 2016, 'Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish', Oncotarget, vol. 7, no. 14, pp. 17547-17564. https://doi.org/10.18632/oncotarget.8163
Aquilino C, Granja AG, Castro R, Wang T, Abos B, Parra D et al. Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish. Oncotarget. 2016 Mar 17;7(14):17547-17564. https://doi.org/10.18632/oncotarget.8163
Aquilino, Carolina ; Granja, Aitor G. ; Castro, Rosario ; Wang, Tiehui ; Abos, Beatriz ; Parra, David ; Secombes, Christopher J. ; Tafalla, Carolina. / Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish. In: Oncotarget. 2016 ; Vol. 7, No. 14. pp. 17547-17564.
@article{ac1b4459dddb4c2db6d3444ac2757428,
title = "Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish",
abstract = "CK9 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to mammalian CCL25. Although CK9 is known to be transcriptionally regulated in response to inflammation particularly in mucosal tissues, its functionality has never been revealed. In the current work, we have demonstrated that CK9 is chemoattractant for antigen presenting cells (APCs) expressing major histocompatibility complex class II (MHC II) on the cell surface. Among these APCs, CK9 has a strong chemotactic capacity for both B cells (IgM+ and IgT+) and macrophages. Along with its chemotactic capacities, CK9 modulated the MHC II turnover of B lymphocytes and up-regulated the phagocytic capacity of both IgM+ cells and macrophages. Although CK9 had no lymphoproliferative effects, it increased the survival of IgT+ lymphocytes. Furthermore, we have established that the chemoattractant capacity of CK9 is strongly increased after pre-incubation of leukocytes with a T-independent antigen, whereas B cell receptor (BCR) cross-linking strongly abrogated their capacity to migrate to CK9, indicating that CK9 preferentially attracts B cells at the steady state or under BCR-independent stimulation. These results point to CK9 being a key regulator of B lymphocyte trafficking in rainbow trout, able to modulate innate functions of teleost B lymphocytes and macrophages.",
keywords = "rainbow trout oncorhynchus mykiss, chemokines, CK9, CCL25, B cells, Immunology and Microbiology Section, Immune response, Immunity",
author = "Carolina Aquilino and Granja, {Aitor G.} and Rosario Castro and Tiehui Wang and Beatriz Abos and David Parra and Secombes, {Christopher J.} and Carolina Tafalla",
note = "ACKNOWLEDGMENTS The authors want to thank Dr. Oriol Sunyer for the anti-IgT and Dr. Uwe Fischer for the anti-CD8 antibodies used in this study. We also want to acknowledge Luc{\'i}a Gonz{\'a}lez Torres for technical assistance. GRANT SUPPORT This work was supported by the European Research Council (ERC Starting Grant 2011 280469), by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH) and by project AGL2011-29676 from the Spanish Ministry of Economy and Competitiveness (MINECO). C. Aquilino was supported by a MINECO PhD student fellowship",
doi = "10.18632/oncotarget.8163",
journal = "Oncotarget",
publisher = "IMPACT JOURNALS LLC",
T1 - Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish
AU - Aquilino, Carolina
AU - Granja, Aitor G.
AU - Castro, Rosario
AU - Wang, Tiehui
AU - Abos, Beatriz
AU - Parra, David
AU - Secombes, Christopher J.
AU - Tafalla, Carolina
N1 - ACKNOWLEDGMENTS The authors want to thank Dr. Oriol Sunyer for the anti-IgT and Dr. Uwe Fischer for the anti-CD8 antibodies used in this study. We also want to acknowledge Lucía González Torres for technical assistance. GRANT SUPPORT This work was supported by the European Research Council (ERC Starting Grant 2011 280469), by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH) and by project AGL2011-29676 from the Spanish Ministry of Economy and Competitiveness (MINECO). C. Aquilino was supported by a MINECO PhD student fellowship
N2 - CK9 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to mammalian CCL25. Although CK9 is known to be transcriptionally regulated in response to inflammation particularly in mucosal tissues, its functionality has never been revealed. In the current work, we have demonstrated that CK9 is chemoattractant for antigen presenting cells (APCs) expressing major histocompatibility complex class II (MHC II) on the cell surface. Among these APCs, CK9 has a strong chemotactic capacity for both B cells (IgM+ and IgT+) and macrophages. Along with its chemotactic capacities, CK9 modulated the MHC II turnover of B lymphocytes and up-regulated the phagocytic capacity of both IgM+ cells and macrophages. Although CK9 had no lymphoproliferative effects, it increased the survival of IgT+ lymphocytes. Furthermore, we have established that the chemoattractant capacity of CK9 is strongly increased after pre-incubation of leukocytes with a T-independent antigen, whereas B cell receptor (BCR) cross-linking strongly abrogated their capacity to migrate to CK9, indicating that CK9 preferentially attracts B cells at the steady state or under BCR-independent stimulation. These results point to CK9 being a key regulator of B lymphocyte trafficking in rainbow trout, able to modulate innate functions of teleost B lymphocytes and macrophages.
AB - CK9 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to mammalian CCL25. Although CK9 is known to be transcriptionally regulated in response to inflammation particularly in mucosal tissues, its functionality has never been revealed. In the current work, we have demonstrated that CK9 is chemoattractant for antigen presenting cells (APCs) expressing major histocompatibility complex class II (MHC II) on the cell surface. Among these APCs, CK9 has a strong chemotactic capacity for both B cells (IgM+ and IgT+) and macrophages. Along with its chemotactic capacities, CK9 modulated the MHC II turnover of B lymphocytes and up-regulated the phagocytic capacity of both IgM+ cells and macrophages. Although CK9 had no lymphoproliferative effects, it increased the survival of IgT+ lymphocytes. Furthermore, we have established that the chemoattractant capacity of CK9 is strongly increased after pre-incubation of leukocytes with a T-independent antigen, whereas B cell receptor (BCR) cross-linking strongly abrogated their capacity to migrate to CK9, indicating that CK9 preferentially attracts B cells at the steady state or under BCR-independent stimulation. These results point to CK9 being a key regulator of B lymphocyte trafficking in rainbow trout, able to modulate innate functions of teleost B lymphocytes and macrophages.
KW - rainbow trout oncorhynchus mykiss
KW - chemokines
KW - CK9
KW - CCL25
KW - B cells
KW - Immunology and Microbiology Section
KW - Immunity
U2 - 10.18632/oncotarget.8163
DO - 10.18632/oncotarget.8163
JO - Oncotarget
JF - Oncotarget
10.18632/oncotarget.8163Licence: CC BY
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/
Final published version, 5.24 MBLicence: CC BY