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Ronald Petersen, MD, PhD, on the State of Care of Alzheimer Disease
Jenna Payesko
The director of the Mayo Clinic Alzheimer Disease Research Center and Mayo Clinic Study of Aging spoke about the current therapeutic landscape of Alzheimer disease, among other topics.
Ronald Petersen, MD, PhD
To Ronald Petersen, MD, PhD, one of the greatest challenges right now in the space of Alzheimer disease is participation in recruitment of clinical trials.
Petersen stresses the importance of clinicians enrolling patients in these trials to uncover new therapies, and while there are symptomatic therapies available, they do not have an effect on the long-term outcome, which is why Petersen and colleagues are hopeful that the field is headed toward the development of disease-modifying therapies
The director of the Mayo Clinic Alzheimer Disease Research Center and Mayo Clinic Study of Aging, spoke with NeurologyLive in an interview to dive deeper into the current therapeutic landscape of Alzheimer disease, among several other topics.
NeurologyLive: What's the current therapeutic landscape of the Alzheimer disease?
Right now in Alzheimer disease from a pharmacologic perspective, we have 4 or so symptomatic drugs on the market, I mean these are drugs thought to ameliorate some of the symptoms of Alzheimer disease and 3 of them are in one drug class called acetylcholinesterase inhibitors and they're meant to increase the activity of the neurotransmitter acetylcholine in the brain, and that's involved with memory, thinking, behavior and the like, so the drugs are meant to keep the amount of that chemical available active longer in the brain. Then there's a fourth drug, a different class, called an NMDA antagonist and this drug, memantine, works on a different chemical system in the brain, a glutamate system, and also sort of modulates its activity.
All of these are again symptomatic treating drugs and what we do not have in the field and where the field is headed we hope, is toward the development of disease-modifying therapies, so these would be therapies that would be designed to get at the underlying cause of the disease namely plaques and tangles, the plaques are made of a protein called amyloid, the tangles are made of protein called tau, and so there are several drug trials underway right now that are aimed at getting at those 2 proteins and trying to remove them from the brain. Clinical trials is a big area of activity in the Alzheimer field right now since we need those drugs to really make a difference in the ultimate outcome of patients over time.
The symptomatic drugs that I discussed earlier really do not have any effect on the long-term outcome, do not extend life or anything of that nature, and while they may improve symptoms, they are basically not thought to do anything with the underlying disease process. We are using those drugs for symptomatic treatments because that's what we have right now, but we're clearly focusing on developing these new therapies that are going to be disease modifying.
Are there any challenges or areas of unmet need that you've noticed?
Well, the big one is participation in recruitment for clinical trials. We still are in the phase where people don't think about getting into a research trial for a new drug like people would with cancer, if you have a cancer that's difficult to treat you would go to an academic medical institution and say what clinical trials do you have for this kind of cancer. People tend not to think about that very much with Alzheimer disease but we need to, so both the general public, the patients, the families, as well as the doctors should be thinking about putting people into clinical trials because that's the only way we're going to really make headway in trying to uncover some of these therapies for Alzheimer use.
This is a big plea to practicing physicians to have you and your patients consider participation in clinical trials.
Is there any clinical trial that you're watching closely?
One, in particular, that's nearing completion is with an antibody called aducanumab (Biogen), an antibody that is injected into the bloodstream and is thought to go into the brain and remove the amyloid from the brain, and the preliminary studies have indicated that it, in fact, does that when you measure the amount of amyloid in the brain with PET scans.
Are there any misconceptions that you think need to be addressed?
Well, I think in the general public and hopefully not in physicians, that Alzheimer disease is sort of a part of normal aging, well geez don't we all get forgetful as we get older? The answer to that is yes, a little bit, but Alzheimer disease is an abnormal protein problem in the brain, and it is a disease. I think we have to avoid ageism if you will, and say well he's old what do you expect because these conditions may very well be treatable.
What are your thoughts on the amyloid hypothesis?
I think amyloid is definitely a player in the Alzheimer disease process. More recently people have been talking about it as a defining feature that Alzheimer disease is defined by the presence of amyloid and tau in the brain and if that's it, then that's it.
Amyloid I think is a major player, but I don't think it's the whole answer by any means or that even treating amyloid MISS 709 processing adequately would eliminate or erase the disease; I think it would have an impact on the disease but I think ultimately we're going to need combination therapy, so treating amyloid, maybe treating tau and other factors along the way. It is a player and its role may vary with the age of the person and stage of the disease, that is amyloid may be very important early on in the disease process and become perhaps less important as a person ages, so the complicating factors.
What are the value of biomarkers?
If you define Alzheimer disease by the presence of amyloid and tau in the brain, you're going to need biomarkers to detect those 2 proteins in the brain and now we can do that in the spinal fluid with lumbar punctures, where we can detect amyloid and tau, and we can do it now with PET scanning. We can do an amyloid PET scan that will identify whether the person has amyloid in the brain and we can do a tau PET scan that defines where the person has tau in the brain, so if you have a positive scan on both of those then you have Alzheimer disease by definition, irrespective of your clinical symptoms. You could be clinically normal, but if you have evidence of amyloid and tau in the brain then the new framework proposal is saying that you have Alzheimer disease, so the biomarkers are critically important and you can imagine for a clinical trial you need to have the presence of the biomarkers so that you can determine if in fact, the person has the target in the brain that the drug is aiming at namely amyloid or tau.
What's your best advice for clinicians treating this patient population?
Be sensitive to early presentations because ultimately, I think intervening on these diseases earlier rather than later is going to be the best approach. When people come in complaining of forgetfulness, not that all forgetfulness is Alzheimer disease, and not that forgetfulness is not common in aging, but trying to sort out the forgetfulness, might, in fact, be meaningful and could be the beginning of a degenerative process in the brain. So clinically being sensitive to the early features and then following the literature and the studies again with regard to the use of biomarkers, when are biomarkers going to be important in a given individual patient, and then hopefully again, with the clinical trials, that we will be able to get people to enroll in clinical trials so that we will develop some effective therapies.
When we're talking about patients and what we can do for them, lifestyle factors can be important as well, and by lifestyle we mean physical exercise, intellectual activity, social activities, things like that, so don't ignore lifestyle factors that can influence perhaps the course, maybe not prevent Alzheimer disease but certainly can alter the course.
Transcript has been edited for clarity.
Disclosure: Ronald Petersen, MD, PhD,
is a paid consultant for Biogen.
Mayo Clinic | Clinical | News | Dementia and Alzheimer Disease | SAP Partners


How do the speech patterns of various characters--such as Joe, Pumblechook, and the convict--differ?
Dickens loved the theater. How is Great Expectations theatrical? To what moments does the novel build? Which scenes have "stagy" qualities?
Find passages where Dickens deliberately withholds information from his readers, but provides hints. Does this heighten interest in the story--or is it unfair and contrived?
How is history blended with fiction in this story?
Find passages that show Dickens' use of sentimentality. For example, examine the scene where the convict dies with tears in his eyes. How do you feel about these instances of sentimentality?


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Someone was giving this away so of course I snatched this up! Cat Among the Pigeons is Poirot mystery and although it takes place in a boarding school, the action is international.
The book opens with a middle-eastern prince getting killed. But before he dies, he passes a packet of incredibly valuable jewels to be smuggled out of the country. Over in England, a teacher has been killed at Meadowbank, a well-regarded boarding school. And since the cousin of the late prince is staying there, there are a lot of important people interested in this. Poirot doesn't really appear until late into the story, but I really enjoy the part where he appeared.
As usual, I really enjoyed this. Most of the mysteries tend to be local, but this one has international implications, which I found to be a refreshing change. The start was a bit confusing because it cut from school to the Middle East and back but I wasn't too confused.
With regards to characters, there are a whole host of interesting people in these books. In particular, I liked Miss Bulstrode, the headmistresses with a forceful personality (there was a subplot on who would succeed her), Adam, an undercover agent, and Julia, a student at the school. Julia, in particular, was lovely to read about because she's brave and sensible but didn't come across as a Mary-Sue.
The one complaint I have is that the portrayal of Middle-Eastern people is very stereotypical. Prince Ali (the prince I mentioned at the beginning) basically dies in a revolution because he's too democratic. In fact, another character basically says that what Middle Eastern people want are tyrants for rulers which was an eye-rolling moment for me. But luckily this was only at the start of the book so it's still something that could be ignored.
Overall, this is an enjoyable story. The beginning is a bit rough but the story gets into its stride once the murders start and I ended up really enjoying the book.

redpajama_set_name: RedPajamaCommonCrawl


text:
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Wanted: Canada's brightest young minds
Sonia Mendes
Ingenium - Canada's Museums of Science and Innovation
Calling all bright, young minds: Applications are now open for the 2021 Ingenium-NSERC STEAM Horizon Awards.
Connecting during COVID: How museums are rethinking engagement in a time of physical distancing
Michelle Campbell Mekarski, PhD
Canada Science and Technology Museum
In the foreseeable future, what does COVID-19 and physical distancing mean for Ingenium and its museums?
Science Literacy Week offers online learning opportunities
Tap into your inner scientist during Science Literacy Week!
Inspiring educational resources
Looking for some inspiration to jump-start learning at home or through your virtual classroom? The education team at the Canada Science and Technology Museum has gathered some of our favourite links to educational, playful, and hands-on resources — which can be done online or offline. We've divided the resources into suggested age groups (but note there are overlaps): 5+ 8+ We've also separated them into categories: Science experiments Computer skills Creation challenges Applications Lectures
New museum program brings the farm right into the classroom
It's hard to tune out a science lesson when there's a chicken on your desk. Thanks to a new mobile education program from the Canada Agriculture and Food Museum, teachers in the Ottawa area can bring a bit of farm life — and a lot of excitement — right into the classroom.
Virtual reality brings the farm life experience to students worldwide
Field trip planning just got a whole lot easier. Thanks to the power of virtual reality, teachers based anywhere in the world can now take their students on an educational tour of the dairy barn at the Canada Agriculture and Food Museum — which is also a working farm in Ottawa, Canada. The museum has partnered with Google Arts & Culture to develop "Explore a Dairy Farm," a virtual reality (VR) expedition available through the Google Expeditions app. Nadine Dagenais Dessaint, who works as an
Social Science & Culture
Youth connect with STEAM subjects through new, hands-on program
A new program at the Canada Science and Technology Museum is getting youth excited about science, technology, engineering, arts, and math (STEAM). Launched last fall, the STEAM Effect Project provides a cost-free opportunity for youth (ages 12 to 17) who do not usually participate in after-school programs, and who don't seem themselves represented in the fields of STEAM. "In our first session, the participants made propeller cars, they made bridges out of K'Nex and tested to see which would hold
Putting the "slam" into science
It's not every day that you can sit back and enjoy a pint of beer while being entertained – and informed – by a professional scientist. But that's exactly the idea behind the concept of the science slam. Modelled after the poetry slam, a science slam challenges scientists to deliver a five-minute, educational talk – while keeping their audience highly entertained. "I love educating others about the work I do, and seeing their eyes light up when I talk about fish and wildlife," says Sarah Walton
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text:
using System;
using System.Configuration;

namespace Nucleo.Configuration
{
	/// <summary>
	/// Represents the class to use for configuration management.
	/// </summary>
	public class ConfigurationManagement
	{
		public static T LoadConfigurationSection<T>(string sectionLocation)
			where T: ConfigurationSection
		{
			Guard.NotNullOrEmpty(sectionLocation);

			return ConfigurationManager.GetSection(sectionLocation) as T;
		}
	}
}

redpajama_set_name: RedPajamaGithub


Jesse Ferreras The Huffington Post B.C.
Vancouverites love their coffee, and they're particular about it.
A couple of weeks back, data revealed that Vancouverites prefer Starbucks over Tim Hortons more than any other Canadian city, Canada.com reported.
That isn't necessarily a reflection of how much they love Starbucks, just that most people won't settle for any cup of joe.
Starbucks doesn't even register on the coffee and tea ratings on Yelp.ca. Instead, Vancouverites lean towards cafes that offer original, fair trade, organic brew more than franchise outlets.
But it's not only the product, favoured cafes also boast funky surroundings, memorable staff and tasty munchies.
"People who visit Yaletown go to Starbucks, people who are from Yaletown go to Agro Cafe," says a Yelp user. Agro Cafe boasts a warm atmosphere and a rustic appearance. They handpick their coffee beans, which are then removed, washed and sun-dried before being brewed into delicious cups of joe.
It's easy to miss when you walk past, but Coo Coo Coffee on Davie Street in Yaletown is a favourite of Yelp readers. They love the shop's original beans, its communal atmosphere and its housemade sandwiches and wraps.
Caffe Artigiano boasts champion baristas and coffees inspired by Italian tradition. Some of their latte art rivals stuff you hang on your wall. It's the only prominent coffee franchise on this list.
Don't let the name throw you, it doesn't have the oppressive, poorly ventilated interior of a Franz Kafka novel. Instead, it offers coffees brewed four different ways in a setting that functions just as effectively as an art gallery.
Innocent Coffee and the Upper Room offers drinks roasted weekly by Origins Organic Coffee and Bows X Arrows Coffee Roaster. Pastries are made daily, and upstairs there's a boutique selling illustrations, gift boxes, greeting cards and books. One thing though: they only serve coffee in paper cups, so bring your own if you have any objections.
Talk about a coffee shop that hardly looks as though it belongs in Vancouver. Caffe Cittadella bills itself as an authentic Italian cafe, located in a 19th-century heritage house. Yelp readers praise the cafe's service, its decor and its tasty lattes.
This one may have more to do with location than coffee, but it's hard to beat the Gallery Cafe in downtown Vancouver. Nestled atop the art gallery entrance, it's a busy destination for the lunchtime crowd and offers mocha, latte, cappuccino and Americano. Not exactly the most robust coffee menu but hey, the people have spoken.
More chocolate shop than coffee shop, Thierry offers some great desserts to go along with a nice brew.
Matchstick Coffee probably boasts one of the best looks for any coffee shop in the city. It's tucked into a small, open space in Mount Pleasant, where baristas offer authentic Latin American coffee from Colombia, Costa Rica and Peru. They also make probably the best almond croissant in the city.
This place is known more for coffee than it is for chocolates, but that just makes it a great place for both! The cafe offers organic, fair-trade coffees and "brewed-on-demand" Clover brand coffee.
Prominently located on the Broadway Corridor near Cambie, Elysian Coffee is a cozy little cafe that provides a great variety of coffee and fresh baked goods. Yelp users call the baristas true connoisseurs of the bean.
It's not exactly fair to stick this company here, given that the next entrant uses their beans, but 49th Parallel Coffee Roasters still ranks highly among Vancouver coffee outlets. The company prides itself on producing beans from farmers that the owners communicate with directly, as well as their "meticulous" cupping of every brew.
Located in Harrison Galleries in Yaletown, the Buzz Cafe offers coffee brewed with 49th Parallel beans, along with a selection of breakfasts and baked goods.
Its website bears nothing but its name, but maybe that's because it doesn't need to pitch you its coffee. Revolver gets high ratings for its NYC-inspired look, its high-quality beans and its rich cappuccino. It's pricey, but in this case you pay for quality.
At the corner of West Pender and Homer streets, Finch's offers fair trade, organic coffee and a lengthy menu of enticing items from bocconcini baguettes to PLTs — that's prosciutto, lettuce and tomato.


Those are the last words in a 46-second video that was watched by more than three million people on YouTube last week. The question was asked of the unseen cameraman by a black woman who had been haranguing a white youth at San Francisco State University for wearing dreadlocks (or the best he could manage with his weedy hair).
I've written about being safe in universities before, but this incident focused on cultural appropriation, which is a new crime discovered by people who think it in fact misappropriation to adopt the cultural expression of another ethnic group. Search me.
Of course the wearing of dreadlocks has a meaning, even if few can agree on it. The haranguee, one Cory Goldstein, went on about Egyptians, ancient ones presumably. Lord Scarman once insisted that Rastafarians were inspired by Masai warriors. Today, dreadlocks are the must-have accessory. In South Africa people wearing them are mugged in Johannesburg by dreaded dread thieves with knives and scissors, who sell the locks to hairdressers who weave them on to eager customers' bonces.
What kind of life-form boasts that it can 'speak human'?


text:
funerals@lyndhurstfuneralhome.com
Grave Maintenance
Comforting Thoughts
Hymn Sheets
Sylvia Hutchinson
HUTCHINSON – SYLVIA DELFINA, NÉE KAM CHIN, of Maxwell Main Road, Christ Church, entered into rest on December 11, 2020. Owner of ÉCAF Products Co. Ltd. Wife of the late LG "Darby" Hutchinson. Mother Frances and Laura Lin. Grandmother of Bodie, Justin and Jona Rapson, Renga Moi and Teji Hutchinson and Jae Johansen. Great Grandmother of Kealani, Kiri, Arya, Caspian and Aidan. Relative of the Kam Chin and Henry families in Trinidad. The funeral leaves Lyndhurst Funeral Home, Passage Road, St. Michael on Tuesday, December 29, 2020 for St. Dominic's Roman Catholic Church, Maxwell, Christ Church., where relatives and friends are asked to meet at 2:00 p.m. for the service. The cortege will then proceed to Christ Church Cemetery for the interment. Flowers may be sent to Lyndhurst Funeral Home no later than 11:00 a.m. on Tuesday.
Date: Dec 29 2020
Christ Church Cemetery, Church Hill, Oistins, Christ Church, Barbados
St. Dominic's Roman Catholic Church
Saint Dominic's Roman Catholic Church, Oistins, Barbados
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Faye Ashby wrote on December 28, 2020 at 9:04 pm:
Dear Frances and Laura Lin, Mrs. Hutchinson was a kind-hearted and generous woman. Our sincere condolences for your loss, Love Brath (Irene), Lorna, Faye and Vicky-Lyn.
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MFS advises that crews are responding to a fire at a at a house.
The location of the incident is Temby Court at Greenwith in Adelaide's northern suburbs.
The incident is causing smoke to drift across Greenwith and surrounding suburbs. Motorists and residents are advised to remain indoors and to close all doors and windows until the smoke has passed.


For the first time in DLS Camps history, we are offering an All-Sports camp!
Looking for a great location for your children (K-3) to have fun, be active, learn and improve their athletic skills this summer? Come join us in a positive, caring and fun environment. Activities included but not limited to: Basketball, Soccer, Volleyball, Dodgeball, Capture the Flag, Kickball, Frisbee and MORE! De La Salle All-Sports Camp provides kids with a unique opportunity to experience a wide array of recreational activities while learning sportsmanship, teamwork and a better understanding of each sport.
Session 1 - July 8-11, 2019 - 8:30-10:30 a.m.
To register for any of the All Sports Camps, click on the camps button below.
For the first time in DLS Camps history, we are offering an Archery camp!
This is a NASP (National Archery in the Schools Program) basic archery program. Students will enjoy learning about the bow and arrow, proper technique and skills to become an accurate archer. Shooting activities include target archery, balloon popping and tic tac toe games. All equipment will be provided for campers. Students with their own equipment may be allowed to use it upon inspection.
This is a beginners class designed to teach students the basics of archery from the history of archery, the components of the equipment, to proper shooting form and accuracy. Equipment is top of the line youth compound bows and arrows.
Session 1 - June 11-13, 2019 - 1-3 p.m.
To register for any of the Archery Camps, click on the camps button below.
The De La Salle baseball camp will give young players a chance to further develop their skills in every facet of the game. The camp will emphasize the proper techniques for each player's position and segment of the game (running, stealing, throwing, receiving, hitting, bunting, pitching, catching, outfield play and infield play). Drills and practice in all categories will be given to help strengthen and develop the player. Games will also be played so the coaching staff will be able to analyze and help the camper in real game situations and scenarios. Each camper will work hard but enjoy while learning the finer points of baseball. Open to incoming 4th-9th graders.
Session 1 - June 10-13, 2019 - 8:30 a.m.-12:30 p.m.
Session 2 - June 24-27, 2019 - 8:30 a.m.-12:30 p.m.
Session 3 - July 8-11, 2019 - 8:30 a.m.-12:30 p.m.
Session 4 - July 15-18, 2019 - 8:30 a.m.-12:30 p.m.
To register for any of the Baseball Camps, click on the camps button below.
We will be covering a wide array of topics and show different ways that each skill can be worked on at home or in the gym. Spaces for this camp will be limited. This camp will be run by our De La Salle Basketball staff.
De La Salle Basketball camps are aimed at creating a fun and safe environment while teaching the fundamentals of the game. Each De La Salle Basketball camp will be staffed by the DLS Basketball staff, current student-athletes and alumni. Shooting, ball handling, passing, rebounding, defense, footwork, 1 on 1 moves and big man moves will all be covered. Our camps will also incorporate and stress having the proper attitude, teamwork and listening skills. Campers will be grouped by skill level and grade. Camp is open to K-incoming 9th graders. Boys and girls are welcome. We look forward to seeing you all this summer at camp!
Session 2 - June 17-20, 2019 - 8:30 a.m.-12:30 p.m.
Session 3 - June 24-27, 2019 - 8:30 a.m.-12:30 p.m.
Session 5 - July 22-25, 2019 - 8:30 a.m.-12:30 p.m.
To register for one of the De La Salle basketball camp sessions, click the camps button below.
Nike Elite Basketball Summer Tournament - June 14th and 15th , 2019!
Bob Ladouceur's Championship Football Camp was established in 1988 to help teach sound, fundamental offensive and defensive football techniques to the pre-high school player. The coaching staff will use demonstration and individual drills to teach basic skills to both beginning and experienced players. Proper warm-up, physical conditioning, skills drills and review are part of each scheduled session. Coach Ladouceur will be assisted by his regular coaching staff and selected former players. Full contact is not a priority at this camp. Open to incoming 4th-9th graders.
June 17-20, 2019 - 8:30 a.m.-12:30 p.m.
Quarterbacks — Stance, exchange, drops, set-up, sprint out, play action, screens, ball handling, option, reading defenses, and field leadership.
Session 1 - June 8, 2019 - 8:30-11:30 a.m.
Session 2 - June 15, 2019 - 8:30-11:30 a.m.
*Two separate camps. Same curriculum for both weeks! Open to incoming 4th-9th graders.
- 16 Top tier Varsity teams from Northern California! June 22nd!
The focus of the Premier Football Camp is to athletes, serious about Football, to the next level. The camp which will run Monday - Thursday will be focused on high level technique mirroring the Practice and Tradition of De La Salle's storied program. At the end of the week the athletes will have a comprehensive road map to success on the Football field and beyond.
+June 17-20, 2019 - 12:30-3 p.m.
To register for any of the Football Camps, click on the camps button below.
Are you looking to take your lacrosse game to the next level? Then come out and join current DLS staff, alumni and professional players as we look to develop and expand lacrosse IQ through a series of 4-day/positional camps. Camps will be held at De La Salle High School for 5th to 12th grade boys. 4-day camps will focus on small group stations leading up to positional play and advanced skills. Players will receive high reps and one-on-one instruction of the core fundamentals of the game such as cradling, passing, shooting, offense and defense. Camps will end with small sided games and competitions. Hope to see you all out there!
To register for any of the Lacrosse Camps, click on the camps button below.
The De La Salle soccer summer camp is a terrific opportunity for boys and girls who look to excel in all aspects of the game. Athletes can expect to participate in competitive drills, skill development exercises and daily competitions between campers. Open to incoming 6th-9th graders.
Regular Session 1 - June 10-13, 2019 - 8:30 a.m.-12:30 p.m.
Open to ALL elite players 8th-12th grade. Focus is on technique, increasing tactical awareness and position specific functional training. Premier - Gold level players preferred as the camp is designed for those players who have already been exposed to an advanced level of training/competition.
July 29 - Aug. 1, 2019 - 8:30-10:30 a.m.
To register for any of the Soccer Camps, click on the camps button below.
We are pleased to be able to provide everyone with a prepatory program to aid in the prevention of injuries, teach athletes how to Olympic lift, teach exercise technique and proper warm up.
De La Salle Strength & Conditioning camps are a great way to give youth access to professional training that will enhance their athletic abilities. DLS's head Strength & Conditioning coach will run the youngsters through development exercises and movements to improve their core strength, coordination, agility, overall strength, power and Speed! Speed training starts in the weight room and here at DLS we embrace that concept. Proper exercise techniques will also be taught to all of our camp youngsters. When they leave camp their running capabilities will be significantly enhanced. Explosiveness and agility will also be taught through youth-friendly plyometrics, partner drills, and competitions. Dynamic warm-ups and static stretching will be included to promote a proper warm-up, flexibility, and overall conditioning. The importance of nutrition in athletics will be presented as well.
Session 1 - June 10-13, 2019 - 1-2:30 p.m.
Session 2 - June 17-20, 2019 - 1-2:30 p.m.
To register for one of the De La Salle Speed, Strength & Agility camp sessions, click the camps button below.
The De La Salle Summer Swimming Clinics are open to all competitive swimmers!
The camps will be progressive in nature over a full 3 weeks. Please click the link HERE for more information!
To register for any of the swimming camps, click the registration button below.
Description: Campers will learn the rules and guidelines for improv as well as several performance type improv games.
The De La Salle track and field camp will give campers the chance to work with outstanding coaches and athletes. The camp will feature personalized instruction in high jump, long jump, triple jump, shot put, discus, sprints, hurdles, relays, and distance events. All participants will learn warm up and strengthening routines that are necessary for maximizing performance and reaching goals. Attention will also be given to the mental component of competition in an effort to properly prepare campers for success in track and field. This camp is for incoming 4th through 9th graders.
Session 1 - June 24-27, 2019 - 8:30 a.m.-12:30 p.m.
To register for any of the track and field camps, click on the camps button below.
The De La Salle Volleyball Camp will give boys and girls entering Grades 4 - 9, the opportunity to learn from the De La Salle coaching staff and former standout student athletes. The camp will emphasize the proper techniques for each players position and segment of the game. Drills and practice in all categories will be given to help strengthen and develop the player.
Session 1 - July 15-18, 2019 - 1-4 p.m.
To register for any of the Volleyball Camps, click on the camps button below.
Description: The De La Salle Water Polo camp is designed to help prepare athletes for their upcoming high school season. The camp will focus on building a fitness base for the start of the season as well as focusing on fundamental ball skills, positioning and game-like situations.
Description: The De La Salle Water Polo age group camp focuses on fundamental ball skills, positioning and game-like situations.
The De La Salle wrestling camp is designed as an introductory and intermediate level camp. We will be emphasizing the fundamentals needed to learn more advanced sport specific wrestling skills and tactics. Our curriculum is geared to prepare campers for beginner and intermediate level competitions. Open to incoming boys ages 10 to 14.
The emphasis is for each of our students to learn the basic fundamental skills needed to wrestle at the junior high and high school levels.
To register for any of the Wrestling camps, click on the camps button below.
*Financial aid is not available for any of our camps.
For more information email summercamps@dlshs.org or call 925.288.8100 ext. 7090.
If you wish to be on our camp distribution list please click the link HERE and fill out your information!


text:
Royítika (engelska: Rogitika, Roitika) är en ort i Grekland.   Den ligger i prefekturen Nomós Achaḯas och regionen Västra Grekland, i den centrala delen av landet,  km väster om huvudstaden Aten. Royítika ligger  meter över havet och antalet invånare är .

Terrängen runt Royítika är varierad. Havet är nära Royítika åt nordväst. Den högsta punkten i närheten är  meter över havet,  km öster om Royítika. Runt Royítika är det ganska tätbefolkat, med  invånare per kvadratkilometer. Närmaste större samhälle är Patras,  km nordost om Royítika. Trakten runt Royítika består till största delen av jordbruksmark.

Klimatet i området är tempererat. Årsmedeltemperaturen i trakten är  °C. Den varmaste månaden är juli, då medeltemperaturen är  °C, och den kallaste är januari, med  °C. Genomsnittlig årsnederbörd är  millimeter. Den regnigaste månaden är februari, med i genomsnitt  mm nederbörd, och den torraste är augusti, med  mm nederbörd.

Kommentarer

Källor

Orter i Västra Grekland

redpajama_set_name: RedPajamaWikipedia


The OnePlus team is back again and this time with the OnePlus 6. Find out what's all to know about the latest flagship it in this post!
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It feels counterintuitive. It seems like you can't go to a tech conference or pick up a business magazine these days without hearing about the push to get more women and girls into computer science. Yet the number of computing jobs is ballooning and the proportion of women available to fill those jobs isn't keeping up. As more industries are being redefined as technology-enabled and more computing jobs exist outside of "technology" companies than within them, the shortage of homegrown talent is hitting crisis levels.
In 2015 there were 500,000 new computing jobs but fewer than 40,000 new computer science graduates to fill them, according to the report. And the US Department of Labor estimates that by 2020 there will be more than 1.4 million computing-related job openings but we'll only be able to fill about 30% of those jobs with US computer science grads. Clearly, one lever in increasing the number of graduates in these programs is to increase the number of women who enroll.
The proportion of women computer science majors peaked at 37% in 1984, then began a decline that sunk to 18% by 2008. Despite the intense focus on the ratio of women in CS over the last eight years, that number hasn't budged.
"We want this research to be a roadmap for how you implement coding in schools," said Julie Sweet, CEO of Accenture, North America, with a goal of tripling the number of women in computing by 2025, increasing share to 39%. "We wanted evidence-based rationale with data and insight to help drive action."
Girls Who Code CEO Reshma Saujani agrees. "There has been some great research on women and culture and how companies can maintain diversity and inclusion. But no one asked girls, 'Why aren't you interested in computer science?'"
First, they report the largest opportunity will be catching girls early in junior high school. Nearly 69% of the total gains under their plan result from increasing interest in computing in middle school. They recommend deepening hands-on computing experience through games and toys, calling on manufacturers to develop and market games and toys that appeal specifically to girls. Girls with exposure to computing games are four times more likely to go into coding than girls without, according to the study.
They also emphasize the need to change girls' perception of coding as "uncool" and "for boys only." This is as much of a problem of stereotypes in the media as it is with the messaging girls are receiving at school and at home. According to Computer Science for All, the government-driven initiative to enable public schools to offer CS in all grades by 2025, portrayals of men as computer scientists and engineers in family films outnumber portrayals of women by more than 14 to 1.
At the high school level, the solution may be mitigating the negative influences that decrease participation in computing. In particular the opportunity to redesign computer science curriculum to appeal to girls' interests and be more hands-on, as well as broaden the contexts that girls encounter CS to include after-school programs and summer camps. These out-of-school-time learning domains frequently offer all-girl environments and engaging opportunities to solve problems using computing, emphasizing ways girls can make an impact on the world.
The study also reports that inspiring teachers have a great impact on students' interest in pursuing computer science — though this is not altogether groundbreaking. What is notable, however, is that there is an even greater increase in girls' interest if that inspiring teacher is a woman. The gender of the teacher had no noticeable impact on boys' motivation. But rather than call on women in technology to leave industry and take up teaching, further exacerbating the problem, existing teachers could be trained in coding to increase the population of CS educators, according to Sweet.
By the time women get to college, the challenge rests with computer science departments to makeover introductory curriculum to broaden appeal and to provide mentors and role models to inspire women to persist once they've chosen the major. Harvey Mudd remains the standard-bearer in the field for increasing their women CS majors from 10% to 40% in just four years by rebranding their intro class from "Introduction to programming in Java" to "Creative approaches to problem solving in science and engineering using Python," by taking their women majors to the Grace Hopper Conference that celebrates women in technology, and by offering a research summer course between freshman and sophomore years. (The switch from Java to Python for the intro class is also notable, since Python is known for having an easier on-ramp while Java is beloved by CS professors because it forces students to explicitly understand the concepts that are sometimes hidden in Python.) Today their stats are even better, with women representing just under half of all CS majors.
Finally, the study reports that 58% of women in computer jobs today did not major in computer science, emphasizing the multiplicity of on-ramps post undergraduate education. 'The door to computing never closes," insisted Saujani.
Now thats's some news worth spreading.


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We have received several inquiries about the power consumption of LCD type monitors. I recently bought one, so I have updated our information about computers.
Computers are very much a part of our modern society even for many people living in the bush. Consequently, we are often asked to design systems for people wishing to use renewable energy. For the home or small office there are two main choices - a conventional desktop or a laptop.
We also tested several monitors.
In April 2001 we measured three Pentium III computers in a shop with 15, 17 and 19" monitors. They all used about 125W measured on the AC side.
The wattage of the following systems (with monitor on) was recently measured on the DC side of the inverter. (Selectronic sine wave).
I recently purchased an AMD 1300 MHz computer with 20GB hard drive, CD writer, modem and 15" LCD monitor. While running as the only load on a 1600W Selectronic SE22 inverter the computer without the monitor used 120 Watts but only an additional 80W if used while the TV was on. The 15" LCD monitor used an additional 12W.
So to conclude, we would suggest a desktop computer will use 50 – 70W plus 60 – 80W for a monitor (12W for LCD) plus inverter losses of 10-30% (depending on the size and efficiency of the inverter and whether or not other loads are on at the same time).
The other option is to consider a lap top. In general, we have found that these draw about 1.8A @ 12V (about 24W) on the DC side. One problem is that most lap tops run on something like 18V. We've found the easiest solution is to run the lap top off our micro inverter which retails for AUD$121. So a lap top is in the order of 8 times more efficient than a standard desktop. This means that one 60 - 80W panel could run your lap top for 8 hours per day. Unfortunately, lap tops have some limitations and are more expensive to buy and repair than desktop units.
Your comments and questions are most welcome; however there is no need to send our newsletter back to us when you reply! If you would like a price or product information, please tell us which country you are from if is not evident from your e-mail address. This allows us to assess if local GST (tax) is applicable or whether 230 volt 50HZ products will work in your country etc.


text:
Item # 128 -- United States of America literature incl "Complete History of the United States Vol. 1 & 2" by A.W. Jacobs, "The Story of a Great Nation" by John Gilmary Shea, "Pictorial History of the United States", "The History of Our Country" by Edward S. Ellis vol. I-VIII, "The Official Military Atlas of the Civil War" by Major George B. Davis, etc.
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United States of America literature incl "Complete History of the United States Vol. 1 & 2" by A.W. Jacobs, "The Story of a Great Nation" by John Gilmary Shea, "Pictorial History of the United States", "The History of Our Country" by Edward S. Ellis vol. I-VIII, "The Official Military Atlas of the Civil War" by Major George B. Davis, etc.


text:
Crocin & Saffron News
What is saffron?
Saffron is the stigma of the Crocus sativus, the most antioxidant-rich plant known and the most expensive spice and herb. For more than 3,000 years, saffron has also been treasured as a treatment for a wide assortment of maladies. Growing evidence of clinical and preclinical studies in recent years has further revealed that saffron and its main active constituents exert potential neuroprotective, nootropic, anti-convulsant, anti-depressive, anxiolytic, antioxidant, anti-inflammatory, hypolipidemic, anti-atherogenic, anti-hypertensive, and even anti-cancer effects.
What is crocin?
Crocin is the main active constituent identified responsible for the amazing health benefits of saffron. It is a type of pigment molecule known as a carotenoid and gives saffron its royal red color. Unlike other carotenoids such as lycopene, β-carotene, lutein, zeaxanthin, etc. which are fat-soluble, crocin is unique as it is the only water-soluble carotenoid in the nature and is not present in ordinary fruits or vegetables. Found as one of the most potent antioxidants and anti-inflammatory agent with multi-target effects to protect cells from chemical and radical damages and to improve memory and cognition, crocin is gradually recognized as the best natural ingredient for our health.
Why is crocin more effective than saffron?
Crocin is the key active constituent that provides the health effects of saffron. Quality of saffron, like any plant materials, varies significantly in amount of crocin which is affected by region, weather, drying process, and other factors. Additionally, saffron has been documented to be subjected to adulteration since Middle Age. Therefore, purified natural crocin offers potent and consistent biological effects that saffron doesn't.
Why is crocin superior to other carotenoids?
Crocin is the only water-soluble carotenoid in nature and readily absorbed by our body, making it more stable and effectively utilized than the other (fat soluble) carotenoids. Published studies demonstrated crocin is more effective and multi-targeting for our health. Crocin is not present in common fruits and vegetable. It is especially beneficial as a component in the supplement for good health. Other carotenoids are available from various food sources, including carrot, tomato, corn, egg yolk, orange fruits, and green vegetables.
Is crocin found anywhere else in nature other than in saffron?
Crocin is not present in common fruits, vegetables, or herbs.
Are there research studies about crocin health beneficial effects?
In the last 20-30 years, many research studies have been published about crocin's potential health benefits. Findings from in vitro, in vivo and human studies, indicated that crocin has significant potential in helping maintain and improve health. Search in the public domain will reveal abundant information about the effects of crocin on many aspects of health conditions.
What is Crocin Rich® ?
Crocin Rich® is the first and only high purity natural crocin reviewed and granted NO OBJECTION by FDA in the USA. It is produced with the most advanced purification techniques under strict quality control. Crocin identity and purity of Crocin Rich® are confirmed and determined by HPLC, LCMS, and QNMR. Crocin Rich® offers optima crocin effects for its products.
What are the benefits of CROCIN RICH products?
CROCIN RICH products deliver the amazing health effects of saffron in an enriched and purified form of crocin. See our Blogs, Crocin & Saffron News.
Are CROCIN RICH products safe?
CROCIN RICH products are designed and formulated with all the active ingredients extracted and purified only from edible natural sources. Each and every ingredient in the product has good safety profile and use history. Certificate of Free Sale from FDA was issued for CROCIN RICH products. As dietary supplements, it is always recommended to consult with your physician or other qualified health professional before taking a new course of supplementation.
Where are CROCIN RICH products manufactured?
All CROCIN RICH products are manufactured in the USA according to Good Manufacturing Practices (GMP).
How are CROCIN RICH products made?
CROCIN RICH products are designed and manufactured with the best active ingredients extracted and purified from the best edible natural sources.
How were CROCIN RICH products developed?
CROCIN RICH products were developed through years of research and development by scientists in the USA, who are experts of natural products/ingredients and have in-depth knowledge of saffron and crocin. They are determined to bring safe, the best, and most beneficial supplement products from nature to the market.
What are the side effects of CROCIN RICH products?
CROCIN RICH products are comprised of the most effective ingredients extracted and purified only from edible natural sources. No adverse effects have been reported by users of CROCIN RICH products.
Are there any cautions regarding the use of CROCIN RICH products?
As is the case with all dietary supplements, you should consult with your doctor or other qualified health professionals regarding the treatment of medical conditions before using this product.
Are CROCIN RICH products genetically engineered?
How do I know CROCIN RICH products work?
CROCIN RICH products provide the highest usage of crocin on the market today. Users having different conditions may feel different effects.
What ensures the potency and consistency of CROCIN RICH products?
CROCIN RICH products are manufactured in the USA according to good manufacturing practice (GMP) with the best quality ingredients. For example, the identity and high purity of the key ingredient, Crocin Rich® is measured and determined by the most advanced analytical technologies, including HPLC (High-performance liquid chromatography), LCMS (Liquid chromatography-mass spectrometry), and qNMR (quantitative NMR) techniques. This ensures consistency of dosage and potency of the product.
What is the difference between the CROCIN RICH products?
Each tablet of CROCIN RICH provides a dose of crocin (equivalent to 90 mg of top-grade saffron) plus lutein and zeaxanthin. Each tablet of CROCIN RICH II provides a higher dose of crocin (equivalent to 275mg top grade saffron), 3X potency of CROCIN RICH.
CROCIN RICH plus is a patented product (US9211298). Each tablet provides a higher dose of crocin (equivalent to 300mg top grade saffron) plus six other potent natural antioxidants and enhancers for best effects. More than 3X potency of CROCIN RICH.
CROCIN RICH products are packaged in a convenient two-month supply (60 coated tablets per bottle).
Which CROCIN RICH product should I use?
While all CROCIN RICH products enhance our health in a range of areas, products at higher dosages prove to be more effective. These products provide meaningful effects for your natural well-being of body and mind*. Particularly, CROCIN RICH plus offers the highest usage of crocin in our patented formulation for the best results.
What if I'm not satisfied with my CROCIN RICH purchase?
If you are not completely satisfied with your purchase, you may return any unopened bottles in 60 days for a full refund.
How much do CROCIN RICH products cost?
Please refer to the Products page, or on Amazon or Ebay for current pricing on all CROCIN RICH products.
Why do CROCIN RICH products cost more than other saffron-based supplements?
Saffron is a very expensive product to cultivate and process. It takes approximately 200 flowers to yield just 1,000 mg (0.035 oz.) of dry saffron threads and costs $2,000 to $5,000 a pound on the market. Saffron has been a subject of high frequent adulteration since Middle-Age. Quality of saffron and content of crocin in saffron vary significantly.
"Saffron Extract" products on the US market are diluted in content and not comparable to saffron itself. "Satiereal", a "Saffron Extract" provides 3-4 times LESS saffron content because it was diluted by adding 6 times of fiber in its extraction process (Nutrition Research 2010, 30: 305–313). In fact, a third party study reported by scientists at Hofstra University found a dietary supplement containing 178 mg satiereal, 100mg naringin, and 2,000 IU vitamin D3 did not have any detectable beneficial effects on body-weight management (Journal of Dietary Supplements 2018,15(6): 965-976). Similarly produced "Saffron Extract" only gives a misleading "better than" saffron impression. Shoppers should compare saffron with "Saffron Extract" products and ask: Is it possible that product of "Saffron Extract" can cost far less than saffron itself.
CROCIN RICH products provide a high dose of the active component, crocin, for meaningful benefits. Crocin Rich® has been carefully reviewed and granted NO OBJECTION by FDA. Crocin identity and purity are determined and ensured by the most advanced analytical technologies, including HPLC (High-performance liquid chromatography), LCMS (Liquid chromatography-mass spectrometry), and qNMR (quantitative NMR) techniques. CROCIN RICH products received Certificate of Free Sale from FDA.
Do CROCIN RICH products contain fillers such as yeast, corn, wheat, gluten, starch, preservatives, or artificial flavors?
Do CROCIN RICH products contain allergens?
CROCIN RICH products are made without any known allergens.
How do I store CROCIN RICH? Does it need to be refrigerated?
CROCIN RICH products are specially offered in coated tablet form, best for potency and stability. It can be stored at room temperature, preferably under dry and cool conditions.
Are there any dangerous chemicals used in the extraction process of crocin?
© 2019, Saffron Health Sciences Powered by Shopify


text:
Marika Kilius (n. 24 martie 1943, Frankfurt am Main) este o fostă patinatoare germană din RFG. Ea a fost campioană mondială și olimpică la patinaj artistic perechi, cariera ei de actriță a fost scurtă dar încununată de succes.

Date biografice
Deja la vârsta de 4 ani a fost interesată pentru patinajul pe rotile, că la vârsta de 15 ani să devină campioană mondială la această disciplină sportivă. Primul ei partener la patinaj a fost Franz Ningel. Împreună cu el a câstigat între 1955 - 1957 titlul de campion național în RFG. În același timp a câștigat de trei ori medalia de bronz la Campionatul European la patinaj artistic perechi, în Budapesta, Paris și Viena. În 1957 la Campionatul Mondial din a Colorado Springs devine vicecampioană. Din anul 1957 are ca partener pe Hans-Jürgen Bäumler cu care câștigă în anii 1958, 1959, 1963 și 1964 campionatul național german. În anul  1964 în Dortmund, contrar prezicerii lui madam Buchela, perechea germană devine campioană mondială, câștigând titlul în fața perechii sovietice favorite, formată din Liudmila Belousova și Oleg Protopopov.

Filmografie
 1964 Pe luciul gheții (Die große Kür), regia Franz Antel
 1967 Das große Glück
 1967 Jetzt schlägt's 13 (film TV)
 1971 Peter Alexander präsentiert Spezialitäten (serial TV, un episod)
 2009 Rabentage

Vezi și
Lista medaliaților olimpici la patinaj artistic

Note

Legături externe

Nașteri în 1943
Patinatori germani
Campioni mondiali la patinaj artistic
Sportivi germani în viață
Competitori la Jocurile Olimpice de iarnă din 1956
Competitori la Jocurile Olimpice de iarnă din 1960
Competitori la Jocurile Olimpice de iarnă din 1964
Nașteri pe 24 martie


text:
Contact Legal Firm
Insurance Defense & Civil Rights
Labor Relations & Employment Law
Land Development & Zoning
Litigation & Alternative Dispute Resolution
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Firm Blog
Fishkill Office
White Plains Office
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Drew Victoria Gamils
Drew Gamils works with the firm's municipal, environmental, land development-zoning and litigation practice groups. She provides general counsel services to municipalities in Westchester and Dutchess Counties regarding all aspects of municipal operations, including land use and zoning matters. Ms. Gamils also provides advice to private clients regarding land use applications and assists the firm's public and private sector clients in complying with the State Environmental Quality Review Act, the New York City Watershed Regulations and other environmental regulatory requirements.
Ms. Gamils joined the firm in 2016 following her graduation from law school.
State and Federal Courts of New York
State Court of New Jersey
New York State Bar Association (Member, Executive Committee, Local and State Government Section; Co-Chair, Social Medial Committee, Environmental & Energy Law Section)
Pace Women's Justice Center Event Committee for Cocktails for a Cause and S.I.P. Series
White Plains Bar Association
Westchester Women's Bar Association
2021 Recipient of the New York State Bar Association Environmental & Energy Law Section Council's Certificates of Merit
New York Metro Super Lawyers Rising Star – Land Use & Zoning (2021)
2016, J.D., cum laude, Pace University School of Law, (Managing Editor, Pace Environmental Law Review)
2013, B.S., summa cum laude, SUNY College of Environmental Science and Forestry
2016, Environmental Law Certificate, Pace University School of Law
Suzanne E. Volpe
George Alissandratos
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text:
<?php

require_once('test_base.php');
require_once('test_util.php');

use Foo\TestMessage;

class GeneratedPhpdocTest extends TestBase
{
    public function testPhpDocForClass()
    {
        $class = new ReflectionClass('Foo\TestMessage');
        $doc = $class->getDocComment();
        $this->assertStringContains('foo.TestMessage', $doc);
    }

    public function testPhpDocForConstructor()
    {
        $class = new ReflectionClass('Foo\TestMessage');
        $doc = $class->getMethod('__construct')->getDocComment();
        $this->assertStringContains('@param array $data', $doc);
        $this->assertStringContains('@type int $optional_int32', $doc);
    }

    /**
     * @dataProvider providePhpDocForGettersAndSetters
     */
    public function testPhpDocForIntGetters($methods, $expectedDoc)
    {
        $class = new ReflectionClass('Foo\TestMessage');
        foreach ($methods as $method) {
            $doc = $class->getMethod($method)->getDocComment();
            $this->assertStringContains($expectedDoc, $doc);
        }
    }

    public function providePhpDocForGettersAndSetters()
    {
        return [
            [
                [
                    'setOptionalInt32',
                    'setOptionalUint32',
                    'setOptionalSint32',
                    'setOptionalFixed32',
                    'setOptionalSfixed32',
                    'setOneofInt32',
                    'setOneofUint32',
                    'setOneofSint32',
                    'setOneofFixed32',
                    'setOneofSfixed32',
                    'setOptionalEnum',
                    'setOptionalNoNamespaceEnum',
                    'setOptionalNestedEnum',
                    'setOneofEnum'
                ],
                '@param int $var'
            ],
            [
                [
                    'setOptionalInt64',
                    'setOptionalUint64',
                    'setOptionalSint64',
                    'setOptionalFixed64',
                    'setOptionalSfixed64',
                    'setOneofInt64',
                    'setOneofUint64',
                    'setOneofSint64',
                    'setOneofFixed64',
                    'setOneofSfixed64',
                ],
                '@param int|string $var'
            ],
            [
                [
                    'getOptionalInt32',
                    'getOptionalUint32',
                    'getOptionalSint32',
                    'getOptionalFixed32',
                    'getOptionalSfixed32',
                    'getOneofInt32',
                    'getOneofUint32',
                    'getOneofSint32',
                    'getOneofFixed32',
                    'getOneofSfixed32',
                    'getOptionalEnum',
                    'getOptionalNoNamespaceEnum',
                    'getOptionalNestedEnum',
                    'getOneofEnum',
                ],
                '@return int'
            ],
            [
                [
                    'setOptionalInt64',
                    'setOptionalUint64',
                    'setOptionalSint64',
                    'setOptionalFixed64',
                    'setOptionalSfixed64',
                    'setOneofInt64',
                    'setOneofUint64',
                    'setOneofSint64',
                    'setOneofFixed64',
                    'setOneofSfixed64',
                ],
                '@param int|string $var'
            ],
            [
                [
                    'getRepeatedInt32',
                    'getRepeatedInt64',
                    'getRepeatedUint32',
                    'getRepeatedUint64',
                    'getRepeatedSint32',
                    'getRepeatedSint64',
                    'getRepeatedFixed32',
                    'getRepeatedFixed64',
                    'getRepeatedSfixed32',
                    'getRepeatedSfixed64',
                    'getRepeatedFloat',
                    'getRepeatedDouble',
                    'getRepeatedBool',
                    'getRepeatedString',
                    'getRepeatedBytes',
                    'getRepeatedEnum',
                    'getRepeatedMessage',
                    'getRepeatedRecursive',
                    'getRepeatedNoNamespaceMessage',
                    'getRepeatedNoNamespaceEnum',
                ],
                '@return \Google\Protobuf\Internal\RepeatedField'
            ],
            [
                [
                    'getMapInt32Int32',
                    'getMapInt64Int64',
                    'getMapUint32Uint32',
                    'getMapUint64Uint64',
                    'getMapSint32Sint32',
                    'getMapSint64Sint64',
                    'getMapFixed32Fixed32',
                    'getMapFixed64Fixed64',
                    'getMapSfixed32Sfixed32',
                    'getMapSfixed64Sfixed64',
                    'getMapInt32Float',
                    'getMapInt32Double',
                    'getMapBoolBool',
                    'getMapStringString',
                    'getMapInt32Bytes',
                    'getMapInt32Enum',
                    'getMapInt32Message',
                    'getMapRecursive',
                ],
                '@return \Google\Protobuf\Internal\MapField'
            ],
            [
                [
                    'setRepeatedInt32',
                    'setRepeatedUint32',
                    'setRepeatedSint32',
                    'setRepeatedFixed32',
                    'setRepeatedSfixed32',
                    'setRepeatedEnum',
                    'setRepeatedNoNamespaceEnum',
                ],
                '@param array<int>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedInt64',
                    'setRepeatedUint64',
                    'setRepeatedSint64',
                    'setRepeatedFixed64',
                    'setRepeatedSfixed64',
                ],
                '@param array<int>|array<string>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedFloat',
                    'setRepeatedDouble',
                ],
                '@param array<float>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedBool',
                ],
                '@param array<bool>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedString',
                    'setRepeatedBytes',
                ],
                '@param array<string>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedMessage',
                ],
                '@param array<\Foo\TestMessage\Sub>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedRecursive',
                ],
                '@param array<\Foo\TestMessage>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setRepeatedNoNamespaceMessage',
                ],
                '@param array<\NoNamespaceMessage>|\Google\Protobuf\Internal\RepeatedField $var'
            ],
            [
                [
                    'setMapInt32Int32',
                    'setMapInt64Int64',
                    'setMapUint32Uint32',
                    'setMapUint64Uint64',
                    'setMapSint32Sint32',
                    'setMapSint64Sint64',
                    'setMapFixed32Fixed32',
                    'setMapFixed64Fixed64',
                    'setMapSfixed32Sfixed32',
                    'setMapSfixed64Sfixed64',
                    'setMapInt32Float',
                    'setMapInt32Double',
                    'setMapBoolBool',
                    'setMapStringString',
                    'setMapInt32Bytes',
                    'setMapInt32Enum',
                    'setMapInt32Message',
                    'setMapRecursive',
                ],
                '@param array|\Google\Protobuf\Internal\MapField $var'
            ],
            [
                [
                    'getOptionalFloat',
                    'getOptionalDouble',
                    'getOneofDouble',
                    'getOneofFloat',
                ],
                '@return float'
            ],
            [
                [
                    'setOptionalFloat',
                    'setOptionalDouble',
                    'setOneofDouble',
                    'setOneofFloat',
                ],
                '@param float $var'
            ],
            [
                [
                    'getOptionalBool',
                    'getOneofBool',
                ],
                '@return bool'],
            [
                [
                    'setOptionalBool',
                    'setOneofBool',
                ],
                '@param bool $var'
            ],
            [
                [
                    'getOptionalString',
                    'getOptionalBytes',
                    'getOneofString',
                    'getOneofBytes',
                    'getMyOneof',
                ],
                '@return string'
            ],
            [
                [
                    'setOptionalString',
                    'setOptionalBytes',
                    'setOneofString',
                    'setOneofBytes',
                ],
                '@param string $var'
            ],

            [
                [
                    'getOptionalMessage',
                    'getOneofMessage'
                ],
                '@return \Foo\TestMessage\Sub'
            ],
            [
                [
                    'setOptionalMessage',
                    'setOneofMessage'
                ],
                '@param \Foo\TestMessage\Sub $var'
            ],
            [
                [
                    'getOptionalIncludedMessage'
                ],
                '@return \Bar\TestInclude'
            ],
            [
                [
                    'setOptionalIncludedMessage'
                ],
                '@param \Bar\TestInclude $var'
            ],
            [
                [
                    'getRecursive'
                ],
                '@return \Foo\TestMessage'
            ],
            [
                [
                    'setRecursive'
                ],
                '@param \Foo\TestMessage $var'
            ],

            [
                [
                    'getOptionalNoNamespaceMessage'
                ],
                '@return \NoNamespaceMessage'
            ],
            [
                [
                    'setOptionalNoNamespaceMessage'
                ],
                '@param \NoNamespaceMessage $var'
            ],
            [
                [
                    'setDeprecatedOptionalInt32',
                    'getDeprecatedOptionalInt32',
                ],
                '@deprecated'
            ],
        ];
    }
}


The Library houses the "corpus" of the array of books which belonged to Luigi Einaudi. It is a collection of about 7.000 rare volumes which represents one of the most prestigious set of works of economists in the world, almost all first editions. These are described in two volumes of the Catalogo della biblioteca di Luigi Einaudi: opere economiche e politiche dei secoli XVI-XIX, edited by Dora Franceschi Spinazzola, published in 1981, updated with a Supplementary volume published in 1991, used as a reference book in great libraries worldwide. You can browse and download them here.
Throughout the arc his life, Luigi Einaudi gathered together an extraordinary array of rare books, mostly on economics but also on political philosophy and history, especially history of Piedmont. Einaudi himself in Viaggio tra i miei libri explains how his library progressively came together: "A private collection […] is like a collector's mirror. It contains the materials of their studies, the spiritual friends in whose company they lived and it conveys the authors and issues they were interested in. It has soul".
Amongst the preferred themes of the Einaudian collection, physiocracy particularly stands out. A more complete group of writings by physiocratical economists could not be found in any part of the world, except for France.
Of great importance is also the collection of works by classic economists. In addition to the first edition of Political discourses by David Hume (1752) there is another one of legendary rarity, the Essay sur la nature du commerce en général di Richard Cantillon (1755), whose bibliographical history has originated several disquisitions.
English classic economists are certainly well represented. Some twenty-seven titles by Adam Smith include Theory of moral sentiments (1759); the first and second editions of Wealth of nations (1776 and 1778), the first and second editions of Additions and corrections (1784) and the first French translation of the second original edition (1781). Luigi Einaudi owned the first (1817) and third (1821) editions of David Ricardo's On the principles of political economy and taxation. Even rarer is the collection regarding Thomas Malthus; amongst his works are the first edition on blue paper of An essay on the principles of population (1798) and the first and second editions of Principles of political economy (1820 and 1836). The Mills are also present in the library with several works, James with Elements of political economy (1821, 1824 and 1826) in its first, second and third editions and John Stuart with some twenty titles, many of which are first editions, including Principles of political economy (1848) and Unsettled questions (1844).
Another important group of books concerns the works of Italian economists from the 18th and early 19th century. The collection is virtually complete with first editions of Beccaria, Verri, Gioia, Bosellini, Fuoco, Scialoja, Ferrara and other important authors.
Finally, amongst other works of considerable rarity which draw an even greater interest by scholars of economic thought, Alitinonfo by Gasparo Scaruffi, released in 1582 for the first time, Breve trattato delle cause che possono far abbondare li regni d'oro e d'argento… by Antonio Serra, published in 1613, the first edition of Della moneta. Libri cinque by the abate Galiani, printed in 1751 (containing a title page printing error saying 1750) are to be mentioned.


text:
Nigeria: Two killed in a foiled suicide attack in Maiduguri
A Local vigilante and a young suicide bomber lost their lives in a foiled suicide bomb attack in Dalori Quarters in Maiduguri Borno state north-east Nigeria.
The attack which occurred on Tuesday morning killed the suspected child suicide bomber and a male security guard who prevented the from gaining access into the mosque.
It was gathered that the suicide bomber planned to attack a Mosque during morning prayer in the area.
The bomber did not succeed in the attempt. As you can see, the bomber tried to enter the mosque but unfortunately, one of our security stopped her.
"The bomber did not succeed in the attempt. As you can see, the bomber tried to enter the mosque but unfortunately, one of our security stopped her. The explosion killed the suicide bomber and one of our men," said Bello Dan Batta, Representative of Borno State Emergency Management Agency (SEMA).
According to one of the worshippers in the mosque, the child suicide bomber detonated the bomb when the security guard overpowered her.
The authorities are yet to make a statement on the incident but emergency security response teams such as National Emergency Management Agency (NEMA) and Borno State Emergency Management Agency (SEMA) have been deployed to the area.
The Nigeria army says Boko Haram insurgents flushed out of the Sambisa forest after camp zero fell were responsible for recent attacks in the north-east of Nigeria.
20 people were killed in an attack in Buraburin area of Maiduguri on December 28, 2016 while another four were killed two weeks ago at a mosque in the University of Maiduguri staff quarters.
Nigeria: Buhari ministerial list expected this week [Morning Call]
Nigeria ministerial nominees list expected this week - Senate prez hints
Suicide attack
Hundreds of Nigerians demonstrate against extrajudicial and militia killings
Nigeria: IDPs protest over food shortage
Boko Haram jihadists kill 7 Chadian soldiers, local guard in ambush
Triple suicide attack by Boko Haram kills at least 30 in Nigeria
Five dead in Boko Haram attack on Chadian army base
Militants kill at least 25 Nigerian soldiers during ambush


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"[Horry] does this all the time. It's not just once in a while, it's consistent. He did it last year in the Finals, he's going to do it again. That's Robert for you."
"I've been taking them in the Finals for . . . years now. The ball came to me in the corner, and I just took the shot."
"I don't care how big your heart is. We just want to come and beat you, no matter how competitive you are."
"When [Shaq] goes to the line and hits his foul shots, we're a very, very good basketball club."


Italy is home to some world-famous festivals and annual events. But there are also lots of smaller festivals taking place which are not quite as well known, celebrating everything from cherry trees to 50s rock'n'roll.
So if you fancy seeing something a bit different on your next trip to Italy, here's our round up of some of the country's quirkier festivals and their dates for 2019.
What more romantic way could there be to celebrate Valentines' Day than in Verona? Famous as the setting for Romeo and Juliet, Verona holds a celebration of romance for several days in February with its streets and squares filled with live concerts and markets. There are also foodie events and cut-price entry to some attractions, including Juliet's house.
This Renaissance town in the province of Modena is famous for its cherry trees, and if you're a fan of cherry blossom then you'll want to visit in late March or early April. As the trees bloom, the town is taken over with a programme of parades, concerts, exhibitions, special restaurant menus and various other activities to enjoy.
This long-established but still unique race attracts thousands of vintage car lovers to Italy every year. A selection of vintage cars travel no-stop from Brescia to Rome and back, with crowds greeting them at numerous Italian towns along the way.
In 2019 the cars will leave Brescia on 15 May and they will arrive in Rome on Thursday 16 May. They will be then back in Brescia on Saturday 18 May, where an awards ceremony will be held.
I you're heading to Sicily this summer, you have the chance to see classical Greek theatre performances in the magical atmosphere of the Greek Theatre in the town of Siracusa. This year's programme includes plays by Euripides and Aristophanes.
As the southern region of Puglia bakes in high temperatures at the end of August, dancers and musicians come together to celebrate the pizzica tarantata, a kind of upbeat, frantic music and dance that originated in the middle ages. It's said to have been how women in the middle ages would vent the frustration and "madness" they felt at being oppressed by a strict patriarchal culture. As a cover, they said it was poisonous spider bites making them so miserable.
This is now one of Europe's most important traditional music festivals, with itinerant performances in villages around the region throughout August ,before a final concertone, or grand concert, that attracts some 200.000 visitors from all over the world.
For one night in June the town of Lungarno is lit by thousands of candles in special glass and wood frames, creating a magical atmosphere for the Luminara of San Ranieri, one of the region's biggest events.
The Luminara of San Ranieri in Pisa is considered one of the major events of the summer of the city and of the entire region. On the evening of the 16th June (the eve of the Patron Saint festivity, San Ranieri) the highlight the outline of the palaces, of the bridges, of the churches and of the towers reflecting the river.
Italy is home to a few big music festivals but the Summer Jamboree, held in Marche, is one of the more unusual ones.
Completely dedicated to American music and culture from the '40s and '50s. Live concerts and markets selling retro gear and vinyl attract crowds of enthusiastic fans from all over Italy and the world. There's also a '40s and '50s classic car show.
In summer a 170 kilomtre stretch of the Riviera, along the Romagna and Marche coastline, from the Lidos of Comacchio to Senigallia, turns pink from sunset until dawn.
Every town interprets the theme in a different way, competing to be the most creative and original, putting on shows, theatre performances and other events. Rimini usually has the biggest party of all. Why pink? No one really seems to know. The tourist board says it's the colour that best represents the Riviera. Either way, this all-night party is always a lot of fun.


This week I'm reviewing Bella Chenille yarns. Yesterday I looked at the anatomy of this yarn and its colorways. Today I'll try out some basic stitch patterns to see how different they look in this yarn.
Stockinette stitch creates clear ridges or columns of stitches.
Bella Chenille has almost zero elasticity, so this means that you as the knitter will need to focus on as even of a tension on your yarn as possible so that the stitches are consistent. The fuzziness of the yarn makes it necessary to manually work any extra loose or extra tightness in an individual stitch into the neighboring stitches.
This next tip is an important one to get gauge. After knitting several rows or rounds of stockinette stitches, grasp as much of the needle and live stitches on it with one hand and the bottom of the knit columns with the other hand and pull to stretch the stitches vertically as a group. Repeat this 'pulling' for the remaining stitches across the needle.
Chenille in stockinette tends to create wide stitches with a deep channel in the middle of each stitch. By pulling it, the yarn goes into the strands that create the typical "V" appearance of a stitch rather than the horizontal strands that make the bumps on the purl side. If you don't stretch the fabric vertically, these horizontal strands are visible through the stitches from the right side.
If you study the picture above you'll notice deeper grooves between each column. These are actually the stacked center of the stitches. The vertical V strands like to snug up close to the neighboring V strands / stitches rather than with their own paired strands.
Horizontal ridges are actually purl bumps which are "hidden" because of the fuzziness of the chenille.
When you want the purl side or the reverse stockinette stitch side of the fabric to be the public side, you'll see that the typical "purl bumps" take on the look of plied yarn in horizontal ridges. The usual zigzag look of purl rows is hidden by the fuzz of the chenille. I really like this look, especially for side to side items.
Bella Chenille in garter stitch rows, has a rippled horizontal ridge look to it, but a wider space between them than in reverse stockinette.
When Bella Chenille is knit into garter stitch rows, the ridges are more like squiggly horizontal bumps with a wider space in between them than in reverse stockinette, and look more like their namesake, the 'caterpillar', I mentioned in yesterday's post. These mitered squares are part of a blanket pattern I'll show you later this week.
1×1 ribbing looks itself in Bella Chenille, and moss stitch is the best way to remove the very ridge-like appearance of the other basic stitches shown above.
Lastly, when you knit 1×1 ribbing with Bella Chenille, you'll achieve the more characteristic columns of Vs separated by bumps. In moss stitch, the horizontal and vertical ridges are broken up and the fabric loses the strong grain in either direction, making it look more homogeneous. I also think the squishy factor is heightened in the moss stitch fabric. This last photo is taken from one of the free patterns I'll feature tomorrow.