text:
You searched for +publisher:"University of New Orleans" +contributor:("Steeby, Elizabeth"). Showing records 1 – 14 of 14 total matches.
1. Mosley, Matthew. The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter.
Degree: MA, English, 2010, University of New Orleans
URL: https://scholarworks.uno.edu/td/1176
► Langston Hughes' novel Not Without Laughter works within the historically narrow framework of African American uplift ideology. Hughes implies Booker T. Washington's racial uplift ideology… (more)
▼ Langston Hughes' novel Not Without Laughter works within the historically narrow framework of African American uplift ideology. Hughes implies Booker T. Washington's racial uplift ideology from Up From Slavery within Aunt Hager Williams. In addition, Hughes implies W.E.B. DuBois' racial uplift ideology from Souls of Black Folk within Tempy Siles. In both characters, he criticizes the ideologies. In addition, the ideologies work toward an initial construction of masculinity for Sandy, the protagonist, and ultimately undermine an argument for gender equality. Advisors/Committee Members: Bryant, Earle V., Lackey, Kris, Steeby, Elizabeth.
Subjects/Keywords: race; African American; Langston Hughes; uplift; masculinity; gender; blues; DuBois; Washington; Souls of Black Folk; Up from Slavery; Harlem Renaissance; middle-class; ideology; bourgeois
Mosley, M. (2010). The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1176
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mosley, Matthew. "The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter." 2010. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1176.
Mosley, Matthew. "The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter." 2010. Web. 23 Jan 2020.
Mosley M. The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter. [Internet] [Thesis]. University of New Orleans; 2010. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1176.
Mosley M. The Feminine Representation of Booker T. Washington and W.E.B. DuBois in Langston Hughes' Not Without Laughter. [Thesis]. University of New Orleans; 2010. Available from: https://scholarworks.uno.edu/td/1176
2. Walker, Erin. Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf".
► In Annie Proulx's interview with Charlie Rose, she states that her stories come "from place." Ecocriticism has been the predominant lens with which to understand… (more)
▼ In Annie Proulx's interview with Charlie Rose, she states that her stories come "from place." Ecocriticism has been the predominant lens with which to understand Proulx's work; however, ecocriticism's nebulous tenets and theoretical deficiencies perpetuate sentimental pastoralism of geographical determinism. The shaping impact of Wyoming's environment in Proulx's work lends itself to an evolutionary perspective. Proulx's fiction, like evolutionary theory, examines humanity's unique, reciprocal relationship with nature. The evolutionary approach provides readers with a framework to understand the human relationship to our environment, a theme Proulx's work examines. This approach also augments current criticism that notes the importance of place but does not utilize the relevant framework of evolution. Current evolutionary theory provides the theoretical framework necessary to shed light on the relationship between Proulx's colorful characters and the environment that shapes them. Utilizing this evolutionary framework and textual analysis, I examine two short stories, "The Half-Skinned Steer" and "Wamsutter Wolf." Advisors/Committee Members: Easterlin, Nancy, Lackey, Kris, Steeby, Elizabeth.
Subjects/Keywords: Proulx; Annie; Darwinian theory; Male-male competition; "Wyoming Stories"
Walker, E. (2010). Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf" . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1248
Walker, Erin. "Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf"." 2010. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1248.
Walker, Erin. "Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf"." 2010. Web. 23 Jan 2020.
Walker E. Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf". [Internet] [Thesis]. University of New Orleans; 2010. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1248.
Walker E. Place Matters: An Evolutionary Approach to Annie Proulx's "The Half-Skinned Steer"and "Wamsutter Wolf". [Thesis]. University of New Orleans; 2010. Available from: https://scholarworks.uno.edu/td/1248
3. Perniciaro, Leon. Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game.
► In this paper, I consider how Robert Heinlein's Starship Troopers (1959) and Orson Scott Card's Ender's Game (1985) allegorically treat U.S. Cold War fears of… (more)
▼ In this paper, I consider how Robert Heinlein's Starship Troopers (1959) and Orson Scott Card's Ender's Game (1985) allegorically treat U.S. Cold War fears of invasion by the Soviet Union. Given the texts' historical relationship to the Vietnam War and their use of very similar science fiction tropes (namely, invasion by communistic, insect-like aliens), I argue that Orson Scott Card reimagines the binary Cold War conflict, softening the rhetoric of Starship Troopers and allowing for a more qualified understanding of the relationship between the U.S.S.R. and the U.S. Through this analysis, I also consider how science fiction is a useful tool of cultural criticism in that it posits future worlds so as to reflect contemporary social concerns. Advisors/Committee Members: Steeby, Elizabeth, Hazlett, John, Lackey, Kris.
Subjects/Keywords: Militarism in science fiction; the Vietnam War; cultural studies; Starship Troopers; Ender's Game; representations of the Cold War in science fiction
Perniciaro, L. (2011). Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1338
Perniciaro, Leon. "Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game." 2011. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1338.
Perniciaro, Leon. "Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game." 2011. Web. 23 Jan 2020.
Perniciaro L. Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game. [Internet] [Thesis]. University of New Orleans; 2011. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1338.
Perniciaro L. Shifting Understandings of Imperialism: A Collision of Cultures in Starship Troopers and Ender's Game. [Thesis]. University of New Orleans; 2011. Available from: https://scholarworks.uno.edu/td/1338
4. Santucci, Bethany. "Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South.
► Giuseppe Emilio Rocconi's life narrative, The Story of My Life (1958), represents the hardships of immigration and assimilation through meditations on home, family, and… (more)
▼ Giuseppe Emilio Rocconi's life narrative, The Story of My Life (1958), represents the hardships of immigration and assimilation through meditations on home, family, and religion. I read his narrative in contrast with white elite narratives that express nostalgia for sharecropping and the segregation era. I see his narrative as a reflection upon the costs of integrating into the white patriarchal economy and his sense of being neither fully Italian nor fully American. Advisors/Committee Members: Steeby, Elizabeth, Piano, Doreen, Lackey, Kris.
Subjects/Keywords: Life narrative; segregation; race; class; gender; New South; doubleness; identity; Italian; immigrant; isolation; Catholicism; sharecropping
Santucci, B. (2011). "Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1344
Santucci, Bethany. ""Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South." 2011. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1344.
Santucci, Bethany. ""Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South." 2011. Web. 23 Jan 2020.
Santucci B. "Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South. [Internet] [Thesis]. University of New Orleans; 2011. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1344.
Santucci B. "Against My Destiny": Reading an Italian Immigrant's Memoir in the Early 20th-century South. [Thesis]. University of New Orleans; 2011. Available from: https://scholarworks.uno.edu/td/1344
5. Lane, Emily. Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road.
► Cormac McCarthy's The Road and Dante's the Inferno contain textual and thematic comparisons. While the Inferno creates a world that exhibits the worst fears… (more)
▼ Cormac McCarthy's The Road and Dante's the Inferno contain textual and thematic comparisons. While the Inferno creates a world that exhibits the worst fears of the medieval Catholic subconscious of Dante's time, The Road paints a world of the darkest fears of the current American subconscious. Both texts reflect a critical dystopia that speculates on human spirituality and offers a critique of society through a tour of sin and suffering in a desolate setting. Advisors/Committee Members: Steeby, Elizabeth, Lackey, Kris, Marti, Kevin.
Subjects/Keywords: McCarthy; Cormac; Dante; The Road; Inferno; hell; apocalypse; sin; dystopia; speculative fiction; Arts and Humanities; Comparative Literature
Lane, E. (2010). Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1127
Lane, Emily. "Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road." 2010. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1127.
Lane, Emily. "Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road." 2010. Web. 23 Jan 2020.
Lane E. Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road. [Internet] [Thesis]. University of New Orleans; 2010. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1127.
Lane E. Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road. [Thesis]. University of New Orleans; 2010. Available from: https://scholarworks.uno.edu/td/1127
6. Jemison, Sean. In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl.
► Using a poststructural and reader-response theoretical framework, the author explores competing ideas of interpretation, epistemology, and the problematic nature of truth and meaning in… (more)
▼ Using a poststructural and reader-response theoretical framework, the author explores competing ideas of interpretation, epistemology, and the problematic nature of truth and meaning in Henry James's novel, The Golden Bowl. The author analyzes the ways in which emergent nineteenth century communication technologies, specifically how telegraphy both mediates and facilitates intimacy in a modern landscape. James anticipates modern forms of social media by exploring the nuances and the potential erotic nature of mediated communication and knowledge. Advisors/Committee Members: Boyd-Rioux, Anne, Doll, Dan, Steeby, Elizabeth.
Subjects/Keywords: Henry James; The Golden Bowl; telegram; intimacy; primal scene; epistemology; American Literature; American Material Culture; American Studies; Arts and Humanities; Epistemology; Philosophy of Language; Reading and Language
Jemison, S. (2014). In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1815
Jemison, Sean. "In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl." 2014. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1815.
Jemison, Sean. "In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl." 2014. Web. 23 Jan 2020.
Jemison S. In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl. [Internet] [Thesis]. University of New Orleans; 2014. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1815.
Jemison S. In Between the Dots and Dashes: Telegrams and the Mediation of Intimacy in The Golden Bowl. [Thesis]. University of New Orleans; 2014. Available from: https://scholarworks.uno.edu/td/1815
7. Ngo, Chinh. A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams.
► Using concepts of cognitive evolutionary theory, the author explores how narrative storytelling manifests itself in Denis Johnson's novella Train Dreams. The novella form is… (more)
▼ Using concepts of cognitive evolutionary theory, the author explores how narrative storytelling manifests itself in Denis Johnson's novella Train Dreams. The novella form is also discussed, focusing on its manipulation of linear time, its naturalization of supernatural elements, and its deconstruction of dichotomous relationships. Utilizing the novella's distinct structural and thematic elements, Johnson's text shows the myth of American expansionism and industrial progress and that of Kootenai holism in collision, resulting in a narrative renegotiation that seeks to affirm coexistence and complexity. Advisors/Committee Members: Easterlin, Nancy, Steeby, Elizabeth, Farrin, J. Scott.
Subjects/Keywords: Denis Johnson; Train Dreams; novella form; cognitive evolutionary theory; American literature; myth; Literature in English, North America
Ngo, C. (2015). A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1982
Ngo, Chinh. "A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams." 2015. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1982.
Ngo, Chinh. "A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams." 2015. Web. 23 Jan 2020.
Ngo C. A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams. [Internet] [Thesis]. University of New Orleans; 2015. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1982.
Ngo C. A Fire Stronger than God: Myth-making and the Novella Form in Denis Johnson's Train Dreams. [Thesis]. University of New Orleans; 2015. Available from: https://scholarworks.uno.edu/td/1982
8. Downes, Kathleen M. Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature.
► Throughout the nineteenth century, New Orleans was repeatedly plagued by yellow fever epidemics. In this paper, cultural representations of yellow fever are considered in… (more)
▼ Throughout the nineteenth century, New Orleans was repeatedly plagued by yellow fever epidemics. In this paper, cultural representations of yellow fever are considered in three novels: Baron Ludwig Von Reizenstein's The Mysteries of New Orleans (1854-1855), George Washington Cable's The Grandissimes (1880), and Mollie Evelyn Moore Davis' The Queen's Garden (1900). Because the etiology was unknown during the nineteenth century, yellow fever becomes a floating signifier on which to project the ills they observed in New Orleans society. Yellow fever thus becomes a representation of loose sexual mores, as well as a divinely retributive punishment for slavery, or a sign of adherence to an unequal, antiquated, aristocratic and un-American social system. Yellow fever, in these texts, exposes the struggles with race and racial superiority and illuminates tensions between groups of whites as New Orleans became an American city. Advisors/Committee Members: Rioux, Anne Boyd, Steeby, Elizabeth, Hazlett, John.
Subjects/Keywords: yellow fever, immigration, Haiti, slavery, Creoles; American Literature
Downes, K. M. (2015). Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/2065
Downes, Kathleen M. "Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature." 2015. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/2065.
Downes, Kathleen M. "Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature." 2015. Web. 23 Jan 2020.
Downes KM. Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature. [Internet] [Thesis]. University of New Orleans; 2015. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/2065.
Downes KM. Contagious Deadly Sins: Yellow Fever in Nineteenth-Century New Orleans Literature. [Thesis]. University of New Orleans; 2015. Available from: https://scholarworks.uno.edu/td/2065
9. Zeanah, Emily. Lightless Mornings: A Fine Legacy.
Degree: M.F.A., Film, Theatre, and Communication Arts, 2011, University of New Orleans
URL: https://scholarworks.uno.edu/td/445
► Lightless Mornings: A Fine Legacy represents a personal interrogation and historical account of my great-great -great grandfather, W.D. McCurdy's use of forced labor in… (more)
▼ Lightless Mornings: A Fine Legacy represents a personal interrogation and historical account of my great-great -great grandfather, W.D. McCurdy's use of forced labor in his coalmines and cotton plantations in the Black Belt region of Alabama during the late 19th and early 20th centuries. Through personal research including interviews with other descendents of McCurdy, as well as scholarly research about the practice of convict leasing in Alabama, I explore dynamics of inheritance, economics, power, privilege, race, class, geography, history, family, and identity. Advisors/Committee Members: Bates, Randolph, Hazlett, John, Steeby, Elizabeth.
Subjects/Keywords: Convict leasing, W.D. McCurdy, Genealogy, Prison system, Alabama history, Biography,; Other Arts and Humanities
Zeanah, E. (2011). Lightless Mornings: A Fine Legacy . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/445
Zeanah, Emily. "Lightless Mornings: A Fine Legacy." 2011. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/445.
Zeanah, Emily. "Lightless Mornings: A Fine Legacy." 2011. Web. 23 Jan 2020.
Zeanah E. Lightless Mornings: A Fine Legacy. [Internet] [Thesis]. University of New Orleans; 2011. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/445.
Zeanah E. Lightless Mornings: A Fine Legacy. [Thesis]. University of New Orleans; 2011. Available from: https://scholarworks.uno.edu/td/445
10. Jahed, Yasaman. Simin Daneshvar's Savushun: Examining Gender Under Patriarchy.
► The author covers issues of gender and Iranian national identity as reflected in Iran's first published woman novelist, Simin Daneshvar. Her novel, Savushun, is… (more)
▼ The author covers issues of gender and Iranian national identity as reflected in Iran's first published woman novelist, Simin Daneshvar. Her novel, Savushun, is the first novel to be published by an Iranianwoman in 1969. The novel depicts Iran at the start of the country's governmental factions in 1941 when Reza Shah Pahlavi overthrew years of Iranian dynasty and established a monarchy. This thesis explores how the novel is a vital part of Iran's historical literature as well as essential to the present day discussion of gender and politics, especially for women within the patriarchal paradigm. Advisors/Committee Members: Piano, Doreen, Steeby, Elizabeth, Werner, Robin.
Subjects/Keywords: Iranian Women Writers, Islamic Feminism, Iranian Nationalism, Gender, Literary Subterfuge,; Feminist, Gender, and Sexuality Studies; Other Languages, Societies, and Cultures
Jahed, Y. (2011). Simin Daneshvar's Savushun: Examining Gender Under Patriarchy . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/462
Jahed, Yasaman. "Simin Daneshvar's Savushun: Examining Gender Under Patriarchy." 2011. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/462.
Jahed, Yasaman. "Simin Daneshvar's Savushun: Examining Gender Under Patriarchy." 2011. Web. 23 Jan 2020.
Jahed Y. Simin Daneshvar's Savushun: Examining Gender Under Patriarchy. [Internet] [Thesis]. University of New Orleans; 2011. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/462.
Jahed Y. Simin Daneshvar's Savushun: Examining Gender Under Patriarchy. [Thesis]. University of New Orleans; 2011. Available from: https://scholarworks.uno.edu/td/462
11. Pelot-Hobbs, Lydia. Organizing for Freedom: The Angola Special Civics Project, 1987-1992.
Degree: MS, Planning and Urban Studies, 2011, University of New Orleans
► During the 1980s and 1990s, the US prison system was expanding at an unprecedented rate. This research charts how prisoners at the nation's largest… (more)
▼ During the 1980s and 1990s, the US prison system was expanding at an unprecedented rate. This research charts how prisoners at the nation's largest maximum-security prison, the Louisiana State Penitentiary, commonly referred to as Angola, founded the Angola Special Civics Project to collectively organize for prison reform. Using a combination of oral history and archival research, this thesis argues that the Angola Special Civics Project emerged during an era of political opportunity created by the coupling of political openings and contractions. Unlike outside advocates who focused their reform efforts on internal conditions, the Angola Special Civics Project centering of prisoners' experiential knowledge led them to organize for an end to life sentencing through a combination of research, political education, electoral organizing, and coalition building. This thesis further asserts that their organizing should be conceptualized as a form of prison abolitionist reforms. Advisors/Committee Members: Luft, Rachel, Ehrenfeucht, Renia, Steeby, Elizabeth.
Subjects/Keywords: Louisiana State Penitentiary – Angola, social movements, prison reform, prison; Sociology
Pelot-Hobbs, L. (2011). Organizing for Freedom: The Angola Special Civics Project, 1987-1992 . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/349
Pelot-Hobbs, Lydia. "Organizing for Freedom: The Angola Special Civics Project, 1987-1992." 2011. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/349.
Pelot-Hobbs, Lydia. "Organizing for Freedom: The Angola Special Civics Project, 1987-1992." 2011. Web. 23 Jan 2020.
Pelot-Hobbs L. Organizing for Freedom: The Angola Special Civics Project, 1987-1992. [Internet] [Thesis]. University of New Orleans; 2011. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/349.
Pelot-Hobbs L. Organizing for Freedom: The Angola Special Civics Project, 1987-1992. [Thesis]. University of New Orleans; 2011. Available from: https://scholarworks.uno.edu/td/349
12. Harris, Mary C. Assimilation in Charles W. Chesnutt's Works.
► ABSTRACT Charles W. Chesnutt captures the essence of the Post Civil War period and gives examples of the assimilation process for African Americans into… (more)
▼ ABSTRACT Charles W. Chesnutt captures the essence of the Post Civil War period and gives examples of the assimilation process for African Americans into dominant white culture. In doing so, he shows the resistance of the dominant culture as well as the resilience of the African American culture. It is his belief that through literature he could encourage moral reform and eliminate racial discrimination. As an African American author who could pass for white, he is able to share his own experiences and to develop black characters who are ambitious and intelligent. As a result, he leaves behind a legacy of great works that are both informative and entertaining. Advisors/Committee Members: Bryant, Earle, Steeby, Elizabeth, Lewis, Elizabeth.
Subjects/Keywords: assimilation; amalgamation; Post Reconstruction; integration; Jim Crow; antebellum south; Literature in English, North America, Ethnic and Cultural Minority
Harris, M. C. (2013). Assimilation in Charles W. Chesnutt's Works . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1635
Harris, Mary C. "Assimilation in Charles W. Chesnutt's Works." 2013. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1635.
Harris, Mary C. "Assimilation in Charles W. Chesnutt's Works." 2013. Web. 23 Jan 2020.
Harris MC. Assimilation in Charles W. Chesnutt's Works. [Internet] [Thesis]. University of New Orleans; 2013. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1635.
Harris MC. Assimilation in Charles W. Chesnutt's Works. [Thesis]. University of New Orleans; 2013. Available from: https://scholarworks.uno.edu/td/1635
13. Thompson, Christopher P. Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods.
► Neil Gaiman's use of a hyper-masculine American culture in American Gods sheds light upon the multiple issues surrounding a misogynistic society in which women… (more)
▼ Neil Gaiman's use of a hyper-masculine American culture in American Gods sheds light upon the multiple issues surrounding a misogynistic society in which women are treated as sexual objects and punished for their independence as sexual beings. Gaiman's efforts at highlighting these issues are discreet and hidden under layers of patriarchal expectations, but through the use of his protagonist, Shadow, Gaiman is able to provide an alternative to the society he represents. While he successfully illustrates this more "ideal" society, his endeavors fall short and are almost imperceptible throughout his novel. Gaiman's work in American Gods, while lacking in its overall presence, brings attention to the issues within a hyper-masculine society and it is through this unique, feminist approach that Gaiman is able to present his strong argument for change. Advisors/Committee Members: Doll, Dan, Maxwell, Justin, Steeby, Elizabeth.
Subjects/Keywords: Neil Gaiman; American Gods; feminism; subversion; patriarchy; misogyny; Literature in English, North America; Other Feminist, Gender, and Sexuality Studies; Women's Studies
Thompson, C. P. (2015). Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/2026
Thompson, Christopher P. "Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods." 2015. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/2026.
Thompson, Christopher P. "Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods." 2015. Web. 23 Jan 2020.
Thompson CP. Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods. [Internet] [Thesis]. University of New Orleans; 2015. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/2026.
Thompson CP. Discreet Feminism: Neil Gaiman's Subversion of the Patriarchal Society in American Gods. [Thesis]. University of New Orleans; 2015. Available from: https://scholarworks.uno.edu/td/2026
14. Jensen, Karen. Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon.
► In Song of Solomon, published during a transitional moment in the history of U.S. feminism, Toni Morrison portrays the destructive forces of hegemonic female… (more)
▼ In Song of Solomon, published during a transitional moment in the history of U.S. feminism, Toni Morrison portrays the destructive forces of hegemonic female beauty standards, materialism, and consumerism in a Midwestern African-American community from the 1930s to the 1960s. She reveals a hierarchy in which men define standards of beauty and respectability that enforce white bourgeois ideals. Focusing on five female characters, this thesis examines this hierarchy; the agents who maintain it; and the ways in which it affects female characters who accept and/or reject it. While one of the characters, Hagar, perishes in her attempt to live up to normative beauty standards, her cousin Corinthians is liberated when she leaves her oppressive father and moves in with a working class male partner. Morrison thus creates a viable alternative to strict adherence to materialist values, while representing the destructive force of oppressive beauty norms and standards of respectability. Advisors/Committee Members: Steeby, Elizabeth, Bryant, Earle, Hazlett, John.
Subjects/Keywords: Song of Solomon; female characters; feminism; beauty standards; respectability; consumerism; English Language and Literature
Jensen, K. (2013). Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon . (Thesis). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1743
Jensen, Karen. "Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon." 2013. Thesis, University of New Orleans. Accessed January 23, 2020. https://scholarworks.uno.edu/td/1743.
Jensen, Karen. "Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon." 2013. Web. 23 Jan 2020.
Jensen K. Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon. [Internet] [Thesis]. University of New Orleans; 2013. [cited 2020 Jan 23]. Available from: https://scholarworks.uno.edu/td/1743.
Jensen K. Toni Morrison's Depiction of Beauty Standards in Relation to Class, Politics of Respectability, and Consumerism in Song of Solomon. [Thesis]. University of New Orleans; 2013. Available from: https://scholarworks.uno.edu/td/1743


The 6th Expanded Animation symposium carries on a process launched in 2013 – mapping the wide-ranging domain of animated worlds of imagery beyond the realms of well-trodden paths. The symposium stays the course as originally set at its inception, and presents theoretical positions and perspectives from the art world, the R&D field and the industrial sector. The mission: To function as a driving force advancing an interdisciplinary discourse.
This year's symposium is an inquiry into future interfaces in animation. *Interfaces in Motion* will focus on animation technology at the manifold interface where humans, computers and interaction meet. The emergence in recent years of affordable technologies—e.g. in the areas of virtual production and mixed reality—create openings for new forms of interaction with moving pictures. Tools and digital devices such as head-mounted displays and mixed reality glasses increasingly call into question conventional workflows and forms of presentation. How will future animated films and hybrid forms consisting of filmed sequences and digital content be produced with and for these new technologies? How will these interfaces change the way digital motion pictures are presented and received, and what role does the audience play in this? This symposium is an effort to come up with answers and present approaches from the art world, the R&D field and the industrial sector.
Kicking off the symposium is the Prix Forum in which honorees in the 2018 Prix Ars Electronica's Computer Animation category present their prizewinning works and discuss current trends. This will be followed by several panel discussions having to do with various aspects of "Interfaces in Motion" with artists, scientists, software developers and studios working in the fields of gaming, media design and animation.
*The Lacuna Shifts*, the latest VR application by the artist duo named *DEPART*, addresses the zone where the real world adjoins the virtual one. Right at the outset of this first-person experience, those partaking of a VR environment find themselves amidst a mirror-image of the real, outside world, and set off on a personalized journey inspired by Lewis Carroll's *Alice in Wonderland*. Hannes Rall will elaborate on a current research project that illustrates how conventional animated productions can be expanded by AVR technology. James Paterson presents *Norman*, animation software that received a 2018 Honorary Mention for making it possible to bring to life in a VR environment the traces of movements left behind in a physical space. Volker Helzle will offer insights into the latest research in virtual production, a complex field of postproduction in which the real and the virtual increasingly merge. Gerhard Funk's presentation will showcase interactive works subsumed under the title *Cooperative Aesthetics* that were developed for Deep Space 8K, and show how their audience's collective movements can generate an animated world of imagery. Artistic experiments in the field of stereoscopic animation—from 3-D noise to binocular rivalry—will be the subject of Rainer Kohlberger's presentation. Chunning (Maggie) Guo and YuanBo Zhong's talk is entitled *Re-evolution as the Interface in Generative Animation*. In *The Dematerialisation of Animation*, Birgitta Hosea will discuss works by artists in the expanded cinema movement. Then Sophie Mobbs reports on VR applications in medicine as well as artistic interventions in this field.
Rounding out the symposium will be making-of presentations about prizewinning and well-received works in the field of applied art. *Broken Rules*, an Austrian indie game studio, will give a speech about the emotional design of the prizewinning computer game *Old Man's Journey*. Talks by *Melt* and *field.io*, two design studios doing interdisciplinary work, and the *ZEITGUISED / foam* animation studio will offer insights into the creative process—from VR experiences to large-format audiovisual projections. Plus, many of the presented works will be shown in the Ars Electronica Animation Screening and in VRLab and Deep Space 8K at the Ars Electronica Center.


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Боуторхой () — покинутый аул в Итум-Калинском районе Чеченской Республики.

География
Расположен на правом берегу реки Мулкойэхк, к северо-западу от районного центра Итум-Кали.

Ближайшие населённые пункты и развалины бывших аулов: на северо-западе — бывшие аулы Энисты, Калгой, на северо-востоке — село Борзой, на юго-востоке — бывшие аул Басхой и село Гухой.

Примечания

Исчезнувшие населённые пункты Итум-Калинского района

redpajama_set_name: RedPajamaWikipedia


text:
https://www.middletownpress.com/nationworld/article/American-Muslims-cite-increasing-concerns-about-11790996.php
American Muslims cite increasing concerns about bias, hate crimes
By Kevin Sullivan, The Washington Post
Published 1:39 pm EST, Sunday, February 15, 2015
Fatima Chrifi, a teacher at Georgetown University, center, prays with a group of Muslims and their supporters during Friday prayers outside the White House in Washington, on Feb. 13, 2015, in the wake of the murder of three young North Carolina Muslims. less
Fatima Chrifi, a teacher at Georgetown University, center, prays with a group of Muslims and their supporters during Friday prayers outside the White House in Washington, on Feb. 13, 2015, in the wake of the ... more
Photo: AP Photo/Jacquelyn Martin
RALEIGH, N.C. >> Family members and Muslim leaders mourning three young people shot to death last week by a white neighbor said that whether or not the killer's motivation was religion, anti-Islamic sentiment is a deep and painful problem that American Muslims confront daily.
University, local and religious leaders have publicly cautioned against jumping to conclusions about whether the killings of three, hailed as beloved volunteers and mentors in the area's large Muslim community, were a hate crime motivated by the victims' faith.
But at a solemn outdoor funeral Thursday attended by several thousand people, Mohammad Abu- Salha, the father of two of the victims, called for a federal investigation into the case, which he said "has 'hate crime' written all over it."
The FBI said Thursday evening that it had opened "a parallel preliminary inquiry to determine whether or not any federal laws were violated."
Police have said their initial investigation suggested that Craig Hicks, 46, shot the three university students to death Tuesday because of a long-running dispute over parking at their condominium complex in Chapel Hill, close to the campus of the University of North Carolina. Hicks has been charged with three counts of murder.
President Barack Obama issued a statement Friday on "the brutal and outrageous murders."
"No one in the United States of America should ever be targeted because of who they are, what they look like or how they worship," Obama said.
And yet many believe that is what happened.
Reflecting global interest in the case, the Palestinian government in the West Bank on Saturday condemned the deaths as "terrorism" and called on U.S. authorities to include its investigators in the probe, Reuters reported.
"We consider it a serious indication of the growth of racism and religious extremism which is a direct threat to the lives of hundreds of thousands of American citizens who follow the Islamic faith," the Palestinian Foreign Ministry said in a statement, the wire service reported.
"It's really hard to believe that it wasn't induced by some sort of racism toward them," said Imam Adeel Zeb, Muslim chaplain at Duke University in nearby Durham.
Zeb said the national response to the deaths of Deah Barakat, 23, and Yusor Mohammad Abu-Salha, 21, a married couple, and Abu-Salha's sister Razan, 19, highlights the "double standard" that exists in the United States.
He said that if a Muslim had killed three non-Muslims, the news coverage and public discussion of the case would be vastly different.
"Any time an incident happens and it's done by a Muslim, it has to be because of Islam," Zeb said. "But if it's somebody else, it must be because of mental illness, or something else, like an argument over parking spaces. There is a double standard, and it makes you feel like a second-class citizen."
Imran Aukhil, 30, a close friend of Barakat's family, was for nearly a decade the spokesman for the Islamic Association of Raleigh, where Thursday's funeral took place. Born and raised in North Carolina and a longtime member of the mosque's governing board, he recently moved to New York to work for a consulting firm but flew to North Carolina when he heard the news.
Aukhil said he believed the problem in the United States was greater than anti-Muslim bias; he said the issue was how all U.S. minorities are treated in a culture of "white privilege." "The greatest threat in America is, frankly, white men with grudges and guns," he said at a local coffee shop just before the funeral.
Aukhil said he understood that his language was inflammatory and would anger some people. He said he was speaking bluntly because he was emotional, angry and grieving the loss of three "charitable, loving, kind and generous" friends — and was frustrated by anti-Muslim sentiment in the United States that he says has been growing since Sept. 11, 2001.
"You would think that the way politicians and media outlets talk about it, that Muslims are lurking right around the corner waiting to kill anybody and everybody," he said. "But that is not the case at all. The reality is deranged people, many of whom are white, many of whom are proud Americans with flags all over their cars and their homes, they are the greatest danger to America.
"They are the ones who are committing some of the most atrocious crimes — the Aurora, Colorado, shooting, the Connecticut shooting, how many mass murders committed by white males can we list? That, unfortunately, is completely misrepresented by the media, who say that Islam and Muslims are going to come and destroy America."
Imam Abdullah Antepli, a top Duke University Islamic leader, noted at a news conference Wednesday evening that many Muslim families had kept their children home from school that day because they were worried for their safety. "The sense of alienation, the sense of vulnerability, I cannot describe," Antepli said.
While cautioning that it was too soon to judge whether the shooting was a hate crime, he said Muslim Americans had already been feeling rising tensions, due in part to the rise of the Islamic State in Iraq and Syria.
It is "absolutely the case that rising anti-Islam and anti-Muslim sentiment in American society has revealed its ugliest face over this case," he said. "But I think dwelling on this will only add layers of pain to the families of these three wonderful individuals."
At the funeral, which was held on an athletic field across the street from the mosque to accommodate the huge crowd, most of the focus was on remembering Barakat, who was studying dentistry at the University of North Carolina; his wife, Yusor, who was scheduled to start in the same program in the summer; and Razan, a design student at North Carolina State University.
Abu-Salha called his younger daughter "the breeze of the day — she walked on this Earth lighter than air."
In interviews, people who attended the funeral recalled Barakat's charitable work. He passed out free dental supplies to homeless people in Raleigh and Durham and was planning a trip to Turkey this summer to distribute dental supplies to Syrian refugees there. His wife, whom he married in December, made a similar trip to refugee camps in Turkey last year.
The three have been remembered in moving candlelight vigils Wednesday night at the University of North Carolina and Thursday evening at North Carolina State. They were buried Thursday in simple plots in an Islamic cemetery in the North Carolina countryside.
Amid the tributes and farewells, people discussed whether bias against Muslims might have played a part in the shooting. Many said it was premature to judge before the police finish their investigation. But others said that Abu-Salha was right when he said that hate clearly motivated the "execution-style" murders.
"It was not about a parking spot," Abu-Salha said, calling on Obama to order a federal investigation.
Abu-Salha and others have pointed to Hicks's Facebook postings, in which he professed his atheism and condemned all religions. Hicks's wife and her attorney have denied that the shootings were motivated by the victims' religion.
"What's the difference between Charlie Hebdo and what happened here?" said Molham al-Hasni, referring to the deadly attack on a satirical newspaper by radical Islamist militants.
"In Charlie Hebdo, all the presidents of the world went into the streets to march," Hasni, who said he came to the United States from Syria three years ago, said at the funeral. "When we see a Muslim killer, we say 'terrorist,' but if he's white, we say he's crazy. It's not fair."
Hasni said he was granted asylum in the United States because he was a human rights activist in Syria and feared for his life in the war raging there. He said he is grateful to the United States for helping him and "saving my life," but he still believes that many Americans are biased against Muslims.
"There is no other country in the world that gives Muslims as much freedom and support and kindness as America, broadly speaking," Aukhil said. "But the underlying bias and injustice that Muslims have been subject to for the last couple of decades" is "really starting to get frustrating."
Aukhil said the huge crowds at the vigils and the national outpouring of support for the victims was heartening.
"If there is a silver lining to this, I feel like the tide is changing," he said. "I feel like this has shaken the entire nation, the loss of these three incredibly beautiful people, these innocent people who were beloved by every single person they touched."

redpajama_set_name: RedPajamaCommonCrawl


Welcome to my personal TOY COLLECTION. Below you will find some of the cool items I have collected over the years. Some from Star Wars obviously, I have 40+ years of those toys 🙂 but from some of my other fave film franchises as well. I will try and take the best photos that I can and even include some Video VLOGS to show you what they look like up close and hear my 2 cents on what I think of each piece. I am sure many of you probably own some of the same toys at home.


Armed with chocolate chip cookies, GORMMP (good old raisins, M&Ms and peanuts), and plenty of coffee to keep us going, GemStone Media took time in early March to plan anticipated projects and dream about new project ideas for the next fiscal year. This year we had seven team members on site, and two who skyped in from the U.S. for part of the meeting time. We renewed our desire to see the Holy Spirit lead us in our endeavors as we continue to seek Him in prayer. We are excited to see how God will use us in 2011-2012!


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Addressing climate change and its health issues through collaboration
Joshua Rosenthal and John Balbus told me about a new effort that will draw on scientific expertise across the National Institutes of Health.
Wildfires, extreme weather, and rising sea levels often seem to grab news headlines, but in my view, less attention is paid to how such climate change-related events can affect human health in immediate and profound ways — and what can be done about it.
Whether the problem is heat-related illness, heightened severity of allergies, or transmission of malaria and Lyme disease, scientists have connected the dots back to our changing climate.
"For our efforts to be successful, we will need to leverage health and exposure data, as well as information from weather monitoring and prediction systems," said Rosenthal. (Photo courtesy of Joshua Rosenthal)
I recently spoke with Fogarty International Center Senior Scientist Joshua Rosenthal, Ph.D., and NIEHS Senior Advisor for Public Health John Balbus, M.D., about a NIH wide working group on climate change and human health that they co-lead.
Rosenthal and Balbus explained why the time is right for an NIH-wide focus on addressing health effects of climate change. They described how environmental health scientists working with experts from other fields can fill key research gaps and help tackle major diseases studied across the 27 NIH institutes and centers.
Linking climate, human health
Rick Woychik: For many in the scientific community, it is clear that agencies such as the U.S. Environmental Protection Agency and the National Oceanic and Atmospheric Administration should be involved in climate change research. It may be less clear how NIH fits in or what role human health research can play. Can you explain that connection?
John Balbus: Climate and weather can significantly influence our health, and that has been known since the ancient Greeks.
In recent years, just as one example, we have seen dramatic increases in extreme weather events such as hurricanes, both in the United States and across the world. There have been devastating impacts as individuals — often the most vulnerable in society — have been displaced, or exposed to chemicals or infectious pathogens in flood waters.
So, NIH has an important role in building an understanding of what is going on now. But circumstances will evolve over time, which is why it is also critical to try to understand what health effects will be coming in the future.
More than emissions
Joshua Rosenthal: Climate change research is often viewed as a matter of slowing greenhouse gas emissions, and the health science community has not really had a big role in that set of activities. However, there is growing recognition that climate change is causing health problems and that actions to address it offer potentially huge health benefits, as well as some risks. We need to find ways to respond effectively and boost resilience.
To John's point about future health effects, I think we are just beginning to understand the transformation of the world's energy systems that is happening right now. This involves a rapid expansion in renewable technologies, including energy storage, and potentially enormous geoengineering projects to mitigate climate change. But very little attention has been paid to understanding the health consequences of such transformation.
Whether we are talking about flooding in Pakistan or high levels of air pollution in sub-Saharan Africa, the burden of climate change is far greater in those places than in Western countries. Joshua Rosenthal
Studies show that these changes, by reducing air pollution from fossil fuel combustion and possibly promoting more plant-based diets, have the potential to vastly improve health and save millions of lives. However, there are also potential downsides.
For example, we will likely face a larger electronic waste problem, with hundreds of millions of solar panels and batteries at the end of their useful life; increased air pollution from greater use of wood burning stoves; and unpredictable health effects from large-scale efforts to reabsorb carbon dioxide. The health science community has an important role here to ensure that lifestyle and energy system changes support public health rather than injure it.
The poor bear the burden
RW: In the U.S., climate change seems to disproportionately affect socially disadvantaged populations. Abroad, it takes a major toll on individuals in developing countries. Can you comment on these health disparities?
Advancing research into climate change and human health will require an all-hands-on-deck scientific approach and the participation of many U.S. agencies. (Image courtesy of NIEHS)
JR: In a sense, there's no surprise here. Health threats from climate change hit children, the elderly, the poor, and the disenfranchised — especially those in low- and middle-income countries — harder than those of us who are well-off enough to insulate ourselves through technology, housing, health services, and so forth.
People in those countries, who often have poor nutrition and who are exposed to pollution and extreme weather, have a much higher burden of infectious and chronic disease, as well as trauma. Whether we are talking about flooding in Pakistan or high levels of air pollution in sub-Saharan Africa, the burden of climate change is far greater in those places than in Western countries.
JB: Mental health also is important to consider. Individuals who live through extreme weather events, natural disasters, and other climate change-related scenarios can experience post-traumatic stress disorder, depression, and anxiety as they grapple with loss of loved ones and property, and other major life disruptions.
"A major goal of the working group is to put together an ambitious and comprehensive research plan that is informed by insights from the field of public health," said Balbus. (Photo courtesy of Steve McCaw / NIEHS)
Thinking broadly
RW: Can you discuss your NIH wide working group? What do you hope to accomplish?
JB: One thing we noticed as we brought the working group together is that our colleagues were raising issues that we hadn't considered before, such as how climate change-related alterations in plants and ecosystems are affecting the nutritional value of foods and botanicals. There is significant interest in thinking about climate change more broadly and developing ways to harness expertise from across the institutes and centers.
Take NIEHS as an example. We have a strong focus on understanding and assessing how environmental exposures, including those related to climate change, affect human health. But the exposure side of climate change is very complex, and it requires integration of data from many research areas. Collaboration is critical, and that is what the working group aims to promote.
We want the group to be a productive planning space for all of NIH to come together and think about how to address climate change through research and innovation.
Ultimately, the will to address climate change is tied to a commitment to lifting up the most vulnerable people now and living on the planet in a way that ensures the well-being of future generations. John Balbus
Support grows
JR: Climate change and extreme weather either indirectly or directly affect most of the diseases and biological systems of interest to NIH. So, all of the institutes, in a sense, have a stake in the issue. Besides, the problems are so big and so complex that no institute could begin to address them alone.
That is why we were thrilled that six institute directors, as well as about 90 researchers and senior leaders, expressed active interest in our working group. Going forward, I believe many others will see this effort as an important way to advance scientific knowledge and really move forward on the NIH mission to improve health.
RW: As we have discussed, the health burden caused by climate change is significant, and it often is borne by individuals who are most disadvantaged. Do you see any reasons to be optimistic?
"I am hopeful that the working group will help to expand knowledge about how extreme weather and other climate factors affect our health and potentially contribute to disease," Woychik said. (Photo courtesy of MDay Photography / Shutterstock.com)
JR: Two things give me hope. On the scientific side, advances in our digital infrastructure and the sophistication of our analytical tools have provided us the ability to do predictive scenario development — that is, more complex climate change and health effects modeling.
The second reason I am optimistic has to do with the resolve of many people around the world, including people in leadership positions, to tackle climate and health as an interconnected issue.
JB: I am going to agree with that perspective and provide a slightly different take.
Our ability to survive and thrive as a species is going to depend on two things. One involves scientific progress, which Josh mentioned. But also important is the ethical and spiritual side.
Ultimately, the will to address climate change is tied to a commitment to lifting up the most vulnerable people now and living on the planet in a way that ensures the well-being of future generations.
I believe that today we are seeing that kind of ethical and spiritual shift take place, which is why I am optimistic that our scientific progress can be harnessed to improve health outcomes.
(Rick Woychik, Ph.D., directs NIEHS and the National Toxicology Program.)
Climate, environment, health
In 2020, Balbus and his NIEHS colleague Trisha Castranio, who manages the institute's Global Environmental Health program, hosted six talks as part of a special Climate, Environment, and Health webinar series.
"We are at a critical juncture in human history, with the opportunity to understand risk factors and vulnerabilities, and to seek solutions to lessen the effects," Balbus said during the first webinar, titled "How Climate Changes Health and Why You Should Care." (See video below.)
• Jason West, Ph.D., from the University of North Carolina at Chapel Hill, spoke June 10, 2020 about how extreme weather events and air pollution will intensify unless there are reductions in greenhouse gas emissions.
• The July 1 webinar celebrated NIEHS Global Environmental Health Day.
• Scientists from the National Oceanic and Atmospheric Administration spoke Aug. 3 about how weather and health data can improve pandemic preparedness.
• On Sept. 29, Georges Benjamin, M.D. executive director of the American Public Health Association, and other speakers discussed how climate change and COVID-19 increased health risks for low-income individuals and minorities.
• Nsedu Obot Witherspoon, executive director of the Children's Environmental Health Network, moderated four talks Oct. 21 on how climate change can increase children's health vulnerabilities.
How Climate Changes Health and Why You Should Care
Watch Balbus present "How Climate Changes Health and Why You Should Care." (1:10:42).
Environmental exposures and Parkinson's disease: connecting the dots
NIEHS joins APHA in celebrating its 150th anniversary
Exposure science tackles climate change
Climate, chemicals, and Carolina focus of NCSOT annual conference
Science of neurodevelopmental disorders advanced by cutting-edge tech


Dhaka's first makerspace for digital fabrication.
All kinds of tools, equipment and knowledge sharing to support the needs of maker community. We are based out of a co-working space called Moar, and currently working on building the community. We are also raising funds for buying some of the basic equipment needed.


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Deals ⋮ Mobile
Massive Limited Time Discounts: BlackBerry Key 2, Huawei Mate 10 Pro, Xiaomi Mi Mix 2S, OnePlus 6 And More
By Ali Salman
It's always a good time to upgrade your smartphone when they're being offered at a discount. If you're not the kind of person and you're using an old smartphone, now might be the right time to upgrade. Today, we have a wide range of smartphones which are up for massive discounts. We're offering discounts on the Xiaomi Mi 8, Xiaomi Mi Mix 2S, OnePlus 6, Huawei Mate 10 Pro and more. So if you're willing to get one for yourself, be sure to act fast as the discount is only available for a limited time.
Get Insane Discounts On Blackberry Key 2, Huawei Mate 10 Pro, OnePlus 6, Xiaomi Mi Mix 2 And More
As we have mentioned earlier, the discounts are available for a limited time only. Moreover, only a limited quantity of products is available so we would recommend you to act fast. Failing to do so would result in the smartphone reverting to its original pricing model.
If you're a Xiaomi fan, there's is no better time to own the company's flagship smartphone. The device features a brand new design with a notch up top and an all-screen display. At the back, you will find a dual lens camera set up along with the fingerprint sensor. As for what's under the hood is 6GB of RAN coupled with 64GB of onboard storage. It also incorporates a 20-megapixel front-facing selfie shooter.
If you're interested, the Xiaomi Mi 8 is available at a discount of 19 percent, coming down to just $329.99. Head over to this link to get it.
Currently, the latest and greatest in Xiaomi's books is the Mi Mix 2S. It features an all-screen design, with no bezels at the top. To my view, Xiaomi Mi Mix 2S is one of the most beautiful devices to come out this year. The all-glass design is pretty sleek and feels pretty stunning. It features 6GB of RAM and 128GB of onboard storage. Xiaomi Mi Mix 2S is also on the top shelves for featuring wireless charging and supporting Bluetooth 5.0.
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Being a OnePlus 6 user myself, I can say it with absolute certainty that there isn't a device as snappy and fluid as this. Moreover, the fact that it features the latest Snapdragon 845 coupled with 6GB of RAM and 64GB of storage, it is a powerhouse. It can handle anything, whether it is performance oriented or even graphics oriented, you will not be disappointed.
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There will be more deals in the future, so stay tuned in for more. What are your thoughts on this week's deals? Would you be willing to get one for yourself? Let us know your views in the comments section below.
Prime Day Deal: PS4 Slim 1TB Console with FREE Spider-Man + Horizon Zero Dawn Download Codes for Just $249.99 [Was $359]
Uzair Ghani • Jul 15
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Prime Day Deals: Apple Watch from $169, iPad from $299, iPad Pro Heavily Discounted, More
Prime Day Deal: 32GB 9.7-inch iPad 6 for Just $249, 128GB for $329 [Up to $100 Off]


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Home Reviews Together2night in-depth review
Try it! Try it!
Members: Hundreds of visitors per week
User Base: Members of Together2night are people of all sexual orientations with no restrictions
Recommended age: Users are in their twenties and thirties, and some members are 50 years and above
Together2night in-depth review
In the online dating industry, many cougar dating sites can be made use of. But together2night seems to stand out. The site is meant for casual hookups and sex. It is a dating platform for flirting and one-night stands. Though some users seek soul mates, it is rare as most members are not in for bonds. Try together2night.com today.
As a result of the simplicity that comes with the website's design, together2night is easy to navigate through for all members that sign up on the site. The interface is understandable as it is user-friendly. There are no hidden features or technicality which may require advance tech knowledge.
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Together2night Membership
This dating site has a wide range of members from different parts of the world. It has the majority of its members from places like the US, Australia, and Canada. Members here are people of all sexual orientations with no restrictions. Users are in their twenties and thirties, and some members are 50 years and above.
After signing up, you are to adequately fill in all your profile, allowing you to find a suitable match. To do this is simple, no irrelevant asking of questions. All you are to fill in the profile questionnaire is core information in line with what you search for.
Matching and Searching
On together2night.com, there are different means for members to approach other members, not minding their gender. With the chat rooms on the site, you can join any to get a flirt partner. For a quick search for a dating partner, the smart search filter allows for easy search.
Pros / Cons
It has a simple and quick sign up process
It has an incredible interface
There are lots of features and tools on the site for easy chatting
It has an outstanding profile quality
It has an app for ease of use
It is fully operational in three location
The membership subscription plan is too expensive
There are profiles with fake identities
To access main features requires an upgrade to premium mode
Together2night App Review
One of the unique parts of Together2night.com is the availability of a mobile application. This application is available for android and ios smartphones, and it can be downloaded for free on the app stores of these devices. With the app, navigating through becomes easier. It allows users to quickly create and edit profiles with no delay. The app for both versions has a nice rating of 3.5/5.0. Compared with the web version, users find the app a bit more limited as it does not appear complete. The app has the same features as it is available on the desktop. With it, users will be able to filter easily.
Together2night App vs. Website
In the together2night app and website, the difference that exists is very minimal. The difference lies in the ease and swift accessibility that the app provides than the website. Then, for the app, it is a bit limited when compared with the website. Aside from this, all other features on the web are the same as the app.
App Ease of Use
The mobile app of together2night is quite straightforward in usage. Users find it more convenient to use for the sign-up, editing of profiles than the web version. The features which it has can be navigated with no complexity or hidden technicality. The app is developed to allow someone new to an online dating platform to use it without any need for being techy.
For more fun and to gain access to different chat rooms on the dating site, it requires an upgrade with different plans and costs. For instance, if you want three days trial, it goes for $2.14, one month plan goes for $20.19, 3 months goes for $41.09, and a six-month plan for a total of $69.20.
Free vs. Paid Access
Paid Access
Sign up and registration
Sending of unlimited messages
Profile creation
Viewing of full-sized pictures
Gallery browsing
Information of other users are known
Limited in messaging
Availability of customer assistance
Searching for users nearby
Extended search features
Basic filters
Incognito feature to hide profile
It gives more profile visibility to the user
Together2night Safety
For every user of a dating site, safety is very paramount. For the safety measure of users on the site, it endeavors that all users undergo an email verification process for their account to be created. The information users provide on the platform while creating an account is kept secure. And for more safety measure, the site has a safety section where essential information for users to stay secured are given.
What People Say about together2night?
On together2night, there have been different opinions and reactions from users. Some users applauded the site/app as a good dating platform to meet partners, flirt, and have fun. Some users in their experience find it difficult to get a partner from the site even after upgrading to premium mode and using the site for months.
Using together2night to search for the type of relationship you want, you may find what you are searching for, and you may not. But, with the chat rooms and other features available, you can have some time out flirting with other members. Though getting a match is not fully guaranteed.
Does Together2night do profile validation and background checks?
On the site, the platform creates a way of validating every user. This is done through the email verification process made compulsory for users before the account will be active and functioning. But for background checks, there is no precise measure on this except when a complaint on any profile is made.
How do I chat on Together2night?
Chatting on the site is easy; after creating an account, browse through the number of profiles on the site and send a wink or other emoji to the user to seek their attention. To make contact through messaging requires an account upgrade.
Does Together2night offer refunds for cancellation?
The site does not offer a total refund after the cancellation of the subscription. But, if the customer support is informed about it and there is a genuine reason to do such, there may be a partial refund.
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Best Mature Dating Apps


Join us as we broadcast on local radio AM 970 & FM Y106 and syndicated stations near you and our LIVE stream from www.LionsLIVE.com We will be giving a recap of the Spring Game, Recruiting, Pre-Season Camp, talking about the Schedule, BIG 10 and the new College Football Championship playoff. Join Big Dude Stephen Davis, Kyle Baublitz, Greg Johnson, Joe Nastasi, Skip Dreibelbis and other former Penn State football players at the 140th Grange Fair. Details at www.LionsLIVE.com - The ONLY network built by the players for you the fans the Forever Lions Network. We are One Team, Past, Present, Future - We Are Forever Lions!


text:
Q: Steps in proof of relationship between inner product and norm A step in a question I am working on goes as follows:
For some arbitrary Inner product space and two arbitrary elements $x,y$, we have the two results:
Let $a \in \mathbb R$, then:
$2 a \text{ Re} \langle x, y \rangle+ a^2 \| y \| \ge 0 \implies \text{ Re} \langle x, y \rangle = 0$
and similarly if $a \in \mathbb C$, so that $a = bi$ then:
$2 b i  \text{ Im} \langle x, y \rangle+ b^2 \| y \| \ge 0 \implies \text{ Re} \langle x, y \rangle = 0$
I don't understand why either of these implications holds obviously

A: The first term depends on $x$, and you can make it as large and positive (or large and negative) as you like by rescaling $x$, whereas the second term doesn't depend on $x$. Therefore the only way the inequalities can hold is if the first term is zero. It's the same as saying that if $Ax+B \geq 0$ for all real $x$, then $A=0$.

redpajama_set_name: RedPajamaStackExchange


Montreal La Presse is laying off 158 employees as it prepares to eliminate its weekday printed newspaper in January.
Publisher Guy Crevier has said that more than 460,000 people read the digital paper weekly. The number of paid print subscribers decreased to 81,000 from 161,000 when the tablet was launched. Most of the remaining readers are expected to go digital.
Three quarters of La Presse's advertising revenues are expected to flow from the tablet in December, plus 10 per cent from its other mobile and web platforms.
Torstar and the parent company of La Presse hold investments in The Canadian Press as part of a joint agreement with a subsidiary of the Globe and Mail.


text:
THE RISE of the SUV shows that carmakers have persuaded many customers that bigger is better. Renault and Fiat Chrysler Automobiles (whose chairman, John Elkann, sits on the board of The Economist's parent company) are hoping to convince investors that the same is true of carmakers. On May 27th FCA, an Italian-American firm, said it was seeking a merger with its French counterpart, itself in a close alliance with Japan's Nissan and Mitsubishi. If a deal goes ahead, it will create an automotive colossus.
Together, the two companies sold nearly 9m cars last year and their combined revenues totalled €170bn ($190bn), with €10bn in operating profits. Only Toyota and Volkswagen (VW), each making over 10m cars a year, are bigger. Add Renault's alliance partners, and the grand total of 15m cars would leave everyone in the dust.
The deal—still subject to approval by Renault's shareholders—can be seen as the legacy of two fallen giants of carmaking. Sergio Marchionne, FCA's charismatic boss who died last year, had called for consolidation of the mass market, where slender profits are partly the result of duplicated investment in similar technologies, such as engines, that do little to differentiate brands. Carlos Ghosn's Napoleonic personality helped him build and run the Franco-...
via Business Feeds
Topic: Economic, News, The Economist: Business


text:
Станция "Карлсплатц" () е бивша станция на Виенската градска парна железница. Сградите над нивото на Карлсплац са широко известен пример за архитектура в стил Ар Нуво. Те са създадени от архитекта Ото Вагнер, който се явява основен консултант на транспортната комисия във Виена и за разлика от другите станции на градската железница са направени със стоманена конструкция и мраморни плочи в интериора.

Станциите са открити за използване през 1899 г. След като части от градската железница са преобразувани в метро се взема решение да се разрушат двете сгради, но по-късно е решено да се съхранят. Те са разглобени, ремонтирани и повторно сглобени на два метра по-голяма височина. След това една от сградите се използва за изложби на Виенския музей с вход към метрото, а другата се използва за кафене.

Източници

Транспорт във Виена


It's that time again! It's time for another UFC PPV card so big there's only one thing we can do at AngryMarks.com - climb to the highest rooftop we can find and scream as loudly as possible that IT'S MMA~! This show is a 20 minute preview of UFC 124: GSP vs. Koscheck II. UFC 124 airs December 101h at 10:00 PM EST, 9:00 Central at the Bell Centre in Motreal, but IT'S MMA~! #3 airs right here on AngryMarks.com! Download it.


Substance abuse treatment that works!
Our emphasis is on health for the whole individual both mind and body.
Overcoming challenges on a path to a sustained recovery.
At Life Recovery Academy, we believe that a transformation of each individual's perspective of self-realization can lead to a more permanent change in the individual's life. Our selection of the dragonfly as part of our mission is based on its universal symbol of change or transformation that has its source in mental and emotional maturity and a deeper understanding of life.
We want to help individuals find the life they want-not necessarily the life they have lived.
By using specific and peer reviewed methodologies to treat disorders such as depression, anxiety, substance abuse/addiction and other issues, our program may have longer and deeper lasting effects in the individuals life. Our program is not designed to only last while the individual is in residence, but to create an opportunity for a life-changing event that can last a life time.
We treat the whole individual using music therapy, yoga, and other methodologies.
We use CBT and REBT along with other empirically proven treatments to treat the whole individual.
We offer support for residents seeking to further their education.
Smart Recovery allows for continued care after the individual leaves our facility with in-person and online support groups offered around the US.
By using scientific and peer reviewed methodologies to treat disorders such as depression,anxiety, substance abuse/addiction and other issues, our program may have longer and deeper lasting effects in the individual's life.
Our program is not designed to only last while the individual is in residence, but to create an opportunity for a life-changing event that can last a lifetime.
Rebecca has gained clinical experience by working in numerous settings including an inpatient psychiatric hospital.
Change can feel impossible at times. We get set in our ways. We can become hopeless. We can feel lost or unfulfilled. We become more of a "human doing" rather than a "human being." We DESERVE more.
It is important to help individuals enrich their physical being as well as their mental health. We offer yoga, music therapy, personal training and canine therapy to assist individuals with improving their health overall. Our canine therapy is a unique opportunity to work with animals in need of a foster home. Residents have the ability to train the dogs while in residence and may adopt them upon leaving the facility if they so desire.
We believe the mind and body are one and that it is important to treat both in a treatment plan designed to improve overall health.
At Life Recovery Academy, we are not a 12 step program. While the 12 step program is a well-known program, it may not meet the needs of every individual. At Life Recovery Academy, we utilize treatment techniques that are designed to assist with treating the whole individual not just the addiction. Much has been learned in recent years about success in treating addiction, and we use this knowledge to assist with meeting long-term goals.


A few months ago, our marketing department was over the moon with the number of free trials we were getting.
We were investing a lot of money in paid advertising and retargeting which more than doubled our free trials signups so we knew we were doing something right.
Our free trials were NOT converting into customers at the rate we were expecting.
If you're running a SaaS, you can probably relate.
You know better than anyone that free trial users are some of the best leads you can get. They've already decided to try your product, maybe over a competitor, so if you're not converting them, you're in trouble.
We needed to do something about it—fast.
By matching each email to each user segment in our funnel, we increased our open rates by 16.5% and increased our click-through rates by 4.2%.
In this article, I'll show you how to create an effective onboarding process for free trial emails so it's easier to turn free trial users into customers.
Want Our Entire Onboarding Email Flow?
Before diving into the specifics of the post, let me give you a quick overview of the results we got.
By using the strategies outlined below, we increased our average open rate by 16.5% and our click-through rate by 4.2%.
It's not that our original user onboarding wasn't awful. We just knew we could do much better.
These ideas led to the implementation of a new email strategy for onboarding our free trials successfully.
If users don't engage with your product during their free trial, it's unlikely they'll become customers once their trial ends. Nothing new there.
So the most important step to onboarding free trial users is to get them using your product as quickly as possible.
Focus, here, on the necessary steps required to see results with your product. The better results users get during their trial, the more likely they are to purchase when their trial ends.
Active users are four times more likely to convert into customers than other free trial users.
Because they've already taken the first step towards purchasing: implementing your product.
In our case, active users have both implemented the tracking code on their site and created their first SleekBox.
But we don't want to leave them at that.
Just because users get started doesn't mean they'll automatically get results.
You need to help them get those results.
By providing them with the necessary resources to help them achieve the best results.
This is where we realized we made our first mistake.
In our old onboarding sequence, we sent users case study emails for inspiration on how to create effective SleekBoxes.
The problem, though, meant we were sending too many case studies emails. And as a result, the click-through rates hovered around 2% for months.
We soon realized we were only confusing users by sending too many different case studies. So we focused instead on creating one quality case study email linking to a single case study that included everything a user would need to create a high-converting SleekBox.
We increased our click-through rate by 111.11%.
Send content that's relevant and specific to where they are in the onboarding process.
Send examples of resources such as free templates, best practice guides, video tutorials, free tools, etc.
Contrary to popular belief, you don't need to finish with a strong sales pitch.
I feel much better having my audience make buying decisions on their own based off of real life results, then hype or exaggeration or a "YOU NEED THIS NOW" from me.
The reason you offer a free trial is to get users to try the product and fall in love with it, right? So if users get great results, the natural choice is for them to buy.
That said, you still need to give users a reason to take action when their trial ends.
It's too easy for users to postpone buying unless you give them a final push in the right direction.
Especially if you offer multiple pricing plans.
In our old onboarding process, we sent an email at the end of a trial trying to convince users to upgrade to a paid plan without informing them of the different plans we offer. We also didn't help them pick the right plan specific to their needs.
So, our new strategy focused on simplifying our plans, making it easy for users to click the plan that fits them.
By listing the plans and only giving them one choice based on their monthly sessions, we went from a click rate of 5% to a click rate of 13%.
You shouldn't copy this free trial email as it's specific to the Sleeknote product. But you can use the same elements to create your own "sales email" where you help users make a decision.
Users that take one or more of the required actions during their trial are partially active users.
These users have shown an interest in starting (aside from signing up for a free trial), but they haven't completed the onboarding process.
This means they won't see any results unless they complete both steps.
In our initial onboarding sequence, we didn't even consider this type of user.
We only differentiated between active and inactive users (I'll get to the latter shortly).
These users are only a few steps away from becoming active users, so you should help them get there.
Trigger your emails based on the actions they've taken so far.
According to CrazyEgg, the first three days of a free trial is the most important.
All emails have a clear call to action: to get started.
However, the approach is different depending on the actions a user takes.
For example, if they've created a SleekBox but haven't implemented their tracking code, we want them to implement the code.
We do the same thing with the users who implement the tracking code but haven't created a SleekBox.
But what happens if they still haven't taken the next step when their trial comes to an end?
We send partially active users an email 24 hours before their trial ends.
We don't know what stopped them from becoming active users, but we know they were interested in using the product.
So, we offer them an extended trial. But to get the extension, they have to complete the final step (create a SleekBox or implement their tracking code).
That way we don't just extend all partially active trials. We only extend the ones where the prospect has an actual interest in seeing results with our product.
This may not be the solution for your business, but it's one way of engaging this type of user.
As the headline implies, inactive users are those who have signed up for a trial and not taken any further action.
At Sleeknote, these users are those who don't install the tracking code AND don't create their first SleekBox.
They're also less likely to become customers when their trial ends, so are they worth spending time on?
They signed up for a reason, remember. So try to address that reason when nudging them get them started.
The amateur and the pro.
You want to belong to the latter, so ignoring inactive users is not an option.
So how do you approach inactive users?
First, you need to consider why they're inactive.
Once you identify the reasons your users are inactive, you can address these reasons in your emails.
While you can't do much about users who signed up by mistake, there are many approaches to engage inactive users.
These emails were almost identical, and they all included a "how-to-get-started" guide.
These emails were driving some engagement, but not as much as we had predicted.
We needed to find a way to address more of our user's concerns without sending more emails.
So, we sent three new emails.
We send email #2 on day two and email #3 on day two (every user gets the welcome email on day one). Then we send a final email 24 hours before their trial ends.
The second email has the same call-to-action as the above. However, here, we remind users that they forgot to get started, and nudge prospects to take action.
This is an excerpt from the email, and it includes a video guide illustrating how to create a SleekBox.
In the final email, we extend their trial to address the "I didn't have time to get started" reason.
This email is identical to the one we send to partially active users except for a few tweaks in the copy including an added focus on problem-solving and fear of missing out (FOMO).
Once a trial has ended we send a final email asking all user segments why the user didn't move forward with Sleeknote.
Then, we link to a one-question survey, and the feedback we get here continuously helps us improve our marketing and our product.
Getting feedback from the people who decided not to buy your product, is one of the best ways to find out how you can improve.
Which Free Trial Emails Will You Use?
Writing free trial emails isn't always easy.
It takes time and many resources to get it right. But once you have an automated sequence in place, you will see results.
As with everything else, it's just about getting started.
Do you have an automation onboarding process for your business? Share your experiences in the comments below.
We track the in-product tasks ourselves in our own software as part of the code. This data is then sent as an event to Intercom (the email service we use to send these emails) and then we set up rules and triggers for the emails based on events and parameters. Regarding the data transfer, we're just in the process of rewriting the code so the data is sent to Segment.io. We recommend using a tool like Segment.io because it integrates with pretty much any tool, so instead of sending the data to each of the tools we use, we send it all to segment.io who then integrates and send the data to our other tools making the data transfer process much more simple.


text:
Same Target Regulated Through Sigma-1 Receptor
New York — May 22, 2014 — Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL), a clinical-stage biopharmaceutical company developing novel drug candidates to treat Alzheimer's disease, other diseases of the central nervous system (CNS) and various types of cancer, welcomes new data published in the current issue of The Journal of Neuroscience that has favorable implications for ANAVEX PLUS, the Company's Alzheimer's disease drug candidate combination.
The scientific findings indicate that too much calcium signaling in neurons may be involved in causing Alzheimer's disease (AD). These calcium alterations can be modulated directly through the inositol triphosphate (IP3) receptor, representing a potential new therapeutic approach to treating AD. The findings indirectly confirm the therapeutic opportunity in Alzheimer's disease for ANAVEX PLUS, an agonist of the sigma-1 receptor (S1R), because the S1R acts as a calcium signaling modulator via IP3.
"Since we know from previous data that the sigma-1 receptor is directly involved in regulating intracellular calcium levels, these recent findings provide further confirmation of the potential for our drug candidate combination ANAVEX PLUS, which increases the expression of the sigma-1 receptor," said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. "These findings also provide added encouragement for the clinical trial of ANAVEX PLUS, which is scheduled to commence in 2014."
The Journal of Neuroscience report confirms that while normal calcium release is important for synaptic transmission and plasticity, too much is toxic. For the first time, by using a genetic approach, the authors showed that exaggerated neuronal calcium signaling can be normalized by decreasing the expression of IP3 protein by 50%. Importantly, this signaling modulation corrected significantly AD-like biochemical, electrophysiological and behavioral impairments observed in two different early and late-stage AD mouse models. The results indicate that the correction of exaggerated calcium signaling rescues the constitutive activation of this transcriptional pathway and dramatically reduces both hippocampal and cortical Amyloid-beta (Abeta) accumulation and hippocampal tau pathology, both hallmarks of AD.
Compelling evidence suggests that the changes in calcium signaling happen in the absence of or precede the appearance of Abeta plaques, indicating that it is an early event that could be a causative trigger of Alzheimer's disease.
According to the newly published report, the enhanced calcium release constitutes a good approximation event in vivo that contributes both to mild cognitive-like impairments and AD-like impairments in the respective animal models. The displayed abnormalities mirror those observed in presymptomatic patients where there is a family link to the disease and in patients suffering from mild cognitive impairment (MCI), a condition that commonly precedes AD.
Therefore, it is possible that environmental influences and genetic susceptibilities that alter calcium signaling play a role in the development of Alzheimer's disease.
The authors conclude that these results suggest that targeting the IP3 signaling pathway could be considered a potential therapeutic strategy for patients harboring mutations linked to AD. The report, entitled "Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis," was authored by Dr. Kevin Foskett and colleagues of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia.
About ANAVEX PLUS
ANAVEX PLUS is a "cocktail" of ANAVEX 2-73 and donepezil (Aricept®). ANAVEX 2-73 is an orally available small molecule with multiple modes of action that holds potential to be disease modifying in Alzheimer's disease. In several Alzheimer's disease models including Tg2576, ANAVEX 2-73 has shown a reversal of memory loss and neuroprotection. Studies with ANAVEX 2-73 have shown a clear synergistic memory effect of up to 80% in combination with donepezil, and up to 7 points cognition improvement in ADAS-Cog at 12 weeks and 5.5 points at 26 weeks in a human calibrated realistic cortical network computer model. Anavex has filed a patent application for the combination of ANAVEX 2-73 and donepezil.
About Anavex Life Sciences Corp.
Anavex Life Sciences Corp. (www.anavex.com) is a clinical-stage biopharmaceutical company engaged in the development of novel drug candidates to treat Alzheimer's disease, other CNS diseases and various types of cancer. ANAVEX 2-73, an orally available drug candidate developed to treat Alzheimer's disease through potential disease modification, has undergone an initial Phase 1 human clinical trial and was well tolerated in doses up to 55mg. Results from preclinical studies indicate that ANAVEX 2-73 demonstrates anti-amnesic and neuroprotective properties. A highly encouraging synergistic effect has also been observed between ANAVEX 2-73 and donepezil (Aricept®). The combined therapeutic, called ANAVEX PLUS, produced up to 80% greater reversal of memory loss in Alzheimer's disease models versus when the drugs were used individually. Anavex is a publicly traded corporation quoted as AVXL.
Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company's most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.
Anavex Life Sciences Corp.
Research & Business Development
Email:info@anavex.com
Shareholder & Media Relations
Outside North America: +1 (416) 489-0092 Email: ir@anavex.com
www.anavex.com
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Anavex Life Sciences Announces First Patient Dosed in Extension Study to its U.S. Phase 2 Clinical Trial of ANAVEX®2-73 in Patients for Rett Syndrome
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Anavex Life Sciences Reports Fiscal 2019 First Quarter Financial Results And Provides Clinical Study Updates
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