text:
EXPRESS INFORMER > News & Politics > UK economy surged by 16 per cent between July and September
UK economy surged by 16 per cent between July and September
UK economy bounced back by 16 per cent between July and September but national debt is the highest for 60 years and GDP is almost NINE PER CENT below where it was at the end of 2019
UK GDP increased by an estimated 16 per cent between July and September
That represents the largest quarterly expansion in the UK ever recorded by ONS
But UK GDP in third quarter still 8.6 per cent below where it was at end of 2019
Meanwhile, Government borrowing still at record levels because of Covid crisis
By Jack Maidment, Deputy Political Editor For Mailonline
The UK economy grew by 16 per cent between July and September after coronavirus lockdown rules were eased – but GDP was still almost nine per cent below where it was at the end of 2019.
The 16 per cent increase in the third quarter of the year represents the largest quarterly expansion in the UK economy ever recorded by the Office for National Statistics since records began in 1955.
The latest ONS data reveals there was a cumulative fall in GDP in the first half of 2020 of 21.2 per cent as the national shutdown from March hammered UK PLC.
The British economy shrunk by three per cent in the first quarter between January and March as the nation felt the first effects of the pandemic.
But that was followed by a fall of 18.8 per cent in the second quarter between April and June as draconian curbs hit hard.
Official data shows the UK economy recorded a massive bounce back between July and September after coronavirus curbs were eased but Government borrowing continues to soar as Chancellor Rishi Sunak props up jobs and businesses
Despite the massive bounce back in the third quarter, the ONS said that UK GDP was still 8.6 per cent below where it was before the pandemic.
That dip is almost twice as large as the cumulative drop in GDP in other G7 leading countries, according to the ONS.
The figures came as the stats body also revealed that the Government set yet another borrowing record in November.
Public sector net borrowing last month was estimated to have been £31.6billion which is £26billion more than was borrowed by ministers in the same month last year.
The £31.6billion figure is the highest November borrowing ever recorded and the third-highest borrowing in any month since records started in 1993.
Overall public sector net borrowing in the first eight months of the current financial year is now estimated to have been just over £240billion.
That is £188.6billion more than between April and November last year and it is the highest borrowing ever recorded in that period.
Public sector debt continues to climb, with the latest estimates suggesting it has increased by just over £300billion in the first eight months of the financial year.
It reached an estimated £2.1trillion by the end of November – equivalent to 99.5 per cent of UK GDP which is the highest debt to GDP ration recorded since 1962.
Recent official forecasts from the Office for Budget Responsibility (OBR) predict borrowing could reach £393.5 billion by the end of the financial year next March, which would be the highest seen since the Second World War.
It comes after the Government launched more than 40 schemes across the UK to help households and businesses through the coronavirus crisis.
One of the most costly has been the furlough scheme for workers, which was last week extended again until April 2021.
The most recent figures from HM Revenue & Customs showed another £3.4 billion worth of claims were made between November 15 and December 13, taking total claims to £46.4billion and 9.9million furloughed jobs.
The ONS said borrowing rose as tax and National Insurance receipts fell by £38.3billion – or 8.6 per cent – year on year in the eight months to November.
But government support for individuals and businesses during the pandemic contributed to a 30 per cent or £147.3billion hike in central government spending.
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Tripadvisor's most popular world destination for 2022 is …
IAN HERBERT: Premier League destroying integrity of the competition with casual agreements to cancel
Corbin Bleu and Jason Earles RETURN for season 3 of High School Musical: The Musical: The Series


The article reports on a 2009 visit to the Gaza Strip made by Ban Ki-moon, secretary-general of the United Nations. The trip took place after the armed conflict between Hamas and the Israeli Defense Force which invaded the region late in 2008. Ban expressed his disapproval at the destruction that had taken place and protested the action to Israeli prime minister Ehud Olmert.
The article reports that the United Nations Secretary-General, Ban Ki-Moon travelled to the Mideast on flight being financed by Hamas, Sunni Islamic group Backer Qatar.
NEW YORK (JTA) -- U.N. Secretary General Ban Ki-moon said an end to Hamas rocket fire was the only means of preventing an Israeli ground invasion of the Gaza Strip.
JERUSALEM (JTA) -- The parents of a 4-year-old Israeli boy killed in a mortar attack called on U.N. Secretary-General Ban Ki-moon to speak out about Hamas war crimes.


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Thank you so much for stopping by to say "Hiya pal!" to us here at the Disney Parks Moms Panel!
I would be happy to help you with your question about stroller rentals at Walt Disney World Resort. You can absolutely rent a stroller for a single day, or you can rent it for a multi-day rental and receive a bit of a discount each day. You pick up the stroller each day in the stroller rental area, and return it to the same location when you leave the park. The next day, you can pick up another stroller at your desired park, in your case Disney's Animal Kingdom.
On 9/6/2017 Sarah from NY Asked: Does anyone have a picture of the stroller you can rent at the parks? Does it have storage underneath?
On 8/13/2017 Denise from IA Asked: where is the best place to rent 2 strollers?


text:
using AutoMapper;
using System;
using System.Linq;
using System.Data.Entity;
using System.Web.Http;
using Vidly.Dtos;
using Vidly.Models;

namespace Vidly.Controllers.API
{
    public class CustomersController : ApiController
    {
        private readonly ApplicationDbContext _context;

        public CustomersController()
        {
            _context = new ApplicationDbContext();
        }

        // GET /api/customers
        public IHttpActionResult GetCustomers(string query = null)
        {
            var customersQuery = _context.Customers
                .Include(c => c.MembershipType);

            if (!String.IsNullOrWhiteSpace(query))
                customersQuery = customersQuery.Where(c => c.Name.Contains(query));

            var customerDtos = customersQuery
                .ToList()
                .Select(Mapper.Map<Customer, CustomerDto>);

            return Ok(customerDtos);
        }

        // GET /api/customers/1
        public IHttpActionResult GetCustomer(int id)
        {
            var customer = _context.Customers.SingleOrDefault(c => c.Id == id);

            if(customer == null)
                return NotFound();

            return Ok(Mapper.Map<Customer, CustomerDto>(customer));
        }

        // POST /api/customers
        [HttpPost]
        public IHttpActionResult CreateCustomer(CustomerDto customerDto)
        {
            if (!ModelState.IsValid)
                return BadRequest();

            var customer = Mapper.Map<CustomerDto, Customer>(customerDto);
            _context.Customers.Add(customer);
            _context.SaveChanges();

            customerDto.Id = customer.Id;

            return Created(new Uri(Request.RequestUri + "/" + customer.Id), customerDto);
        }

        // PUT /api/customers/1
        [HttpPut]
        public IHttpActionResult UpdateCustomer(int id, CustomerDto customerDto)
        {
            if (!ModelState.IsValid)
                return BadRequest();

            var customerInDb = _context.Customers.SingleOrDefault(c => c.Id == id);

            if (customerInDb == null)
                return NotFound();

            Mapper.Map(customerDto, customerInDb);

            _context.SaveChanges();

            return Ok();
        }

        // DELETE /api/customers/1
        [HttpDelete]
        public IHttpActionResult DeleteCustomer(int id)
        {
            var customerInDb = _context.Customers.SingleOrDefault(c => c.Id == id);

            if (customerInDb == null)
                return NotFound();

            _context.Customers.Remove(customerInDb);
            _context.SaveChanges();

            return Ok();
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Hannah Montana es la banda sonora de la primera temporada de la serie original de Disney Channel del mismo nombre. Fue lanzada el 24 de octubre de 2006 por Walt Disney Records. El programa en sí se estrenó a través de Disney Channel el 24 de marzo de 2006; después de convertirse en un éxito comercial inmediato, la producción de su banda sonora comenzó el mes siguiente. Ocho de las trece canciones del álbum son interpretadas por la actriz principal Miley Cyrus, acreditadas a su personaje Hannah Montana. Los grupos The Click Five, Everlife, B5 y el artista Jesse McCartney contribuyen cada uno con una grabación, mientras que un dueto entre Cyrus y su padre Billy Ray Cyrus se incluye como pista final. Hannah Montana se reeditó como una edición especial de dos discos el 20 de marzo de 2007. La banda sonora se promocionó aún más durante la gira The Party's Just Begun Tour de The Cheetah Girls, en la que Cyrus como Hannah Montana actuó como telonero, y su propia gira Best of Both Worlds Tour en donde se presentó como Hannah Montana y como ella misma. La banda sonora es principalmente un disco de pop rock, que ve influencias adicionales de los estilos musicales del teen pop, pop punk y country pop. El contenido lírico gira en gran medida en torno al "poder femenino", el romance adolescente y la doble vida que vive el personaje de Cyrus en el programa.

Hannah Montana recibió generalmente críticas favorables por parte de los críticos musicales, quienes apreciaron su producción en general. Debutó en el #1 del Billboard 200 de los Estados Unidos con unas ventas de 281.000 copias en su primera semana. Al hacerlo, se convirtió en el primer álbum número uno de Cyrus, la primera banda sonora de televisión en alcanzar la posición más alta en la lista, la cuarta banda sonora de The Walt Disney Company en debutar entre los diez primeros de la lista y con solo 14 años Cyrus se convirtió en la artista en general más joven en la historia de la lista en debutar un álbum en la cima del mismo. Desde entonces, el disco ha sido certificado triple platino por la Recording Industry Association of America (RIAA), habiendo superado las ventas de tres millones de copias en los Estados Unidos. La banda sonora se posicicionó moderadamente en las listas de récords internacionales, habiendo alcanzado los veinte primeros puestos en países como Austria, Canadá, Noruega y España.

El tema principal de la serie «The Best of Both Worlds» fue lanzado como sencillo principal de Hannah Montana el 28 de marzo de 2006 en los mercados digitales y más tarde como sencillo en CD. Alcanzó el #92 en el Billboard Hot 100 de los Estados Unidos. «Who Said» fue lanzado como sencillo promocional en plataformas digitales del álbum, alcanzando un máximo de 83 en los Estados Unidos. «If We Were a Movie» fue lanzado como el segundo sencillo en plataformas digitales en 2007 y alcanzó un máximo de 47 en los Estados Unidos. «Rockin 'Around the Christmas Tree», de la edición Holiday, fue lanzado como el tercer sencillo el 16 de octubre de 2007 para descarga digital. «The Other Side of Me» fue lanzado el 10 de febrero de 2009 en iTunes como el cuarto y último sencillo del álbum, alcanzando un máximo de 84 en los Estados Unidos.

Antecedentes y composición
Durante la producción de la primera temporada de Hannah Montana, Cyrus comentó que por el momento, estaban enfocados en mejorar la serie tanto como fuera posible, sin embargo grabar una banda sonora era un plan plausible para el futuro. La serie en sí se estrenó a través de Disney Channel el 24 de marzo de 2006 y se convirtió en un éxito comercial inmediato; con 5,4 millones de espectadores, el episodio piloto le valió al canal la audiencia más alta en su historia en ese momento. Al mes siguiente, se informó que una banda sonora acompañante a la temporada y el álbum de estudio debut de Cyrus habían comenzado su producción, el primero de los cuales estaba programado para ser lanzado durante el otoño de 2006. Se esperaba que estos planes capitalizaran los esfuerzos promocionales previamente utilizados para Hilary Duff, quien había pasado con éxito del personaje principal de la serie de televisión Lizzie McGuire a una carrera en la industria de la música a principios de la década del 2000.

En la serie, Cyrus interpreta al personaje de Miley Stewart, una adolescente que vive una doble vida secreta como la estrella del pop Hannah Montana. Ella afirmó que "la mayoría de las canciones de la primera temporada reflejan el programa, con Miley o Hannah asegurándose de que la otra no sea atrapada o lo que sea", y opinó que las pistas brindaron a los productores de la serie la oportunidad de "asegurarse de que todos entendieran a los personajes". En comparación, Cyrus describió el material posterior utilizado por la serie como "hablar más con los fans". El disco incorpora elementos de estilos musicales de teen pop, pop rock y country pop. Cyrus interpreta ocho de sus trece pistas, las cuales se le acreditan a su personaje Hannah Montana. Las canciones «The Best of Both Worlds» y «This Is the Life» describen la doble vida que mantiene el personaje de Cyrus, mientras que «If We Were a Movie» y «I Got Nerve» abordan un deseo romántico y el "poder femenino", respectivamente.

«Pop Princess» de The Click Five fue descrita por Heather Phares de AllMusic como "pop brillante y poderoso"; también caracterizó a «Find Yourself in You» de Everlife como "la plantilla para el pop-rock de Hannah". La banda sonora termina con el dueto de country pop «I Learned From You» entre Cyrus y su padre Billy Ray Cyrus, que Phares sintió que recibió influencias de la artista Vanessa Carlton. La banda sonora se reeditó más tarde como una edición especial de dos discos, que incluyó la canción «Nobody's Perfect», la cual más tarde se incluyó en la siguiente banda sonora Hannah Montana 2: Meet Miley Cyrus (2007).

Sencillos
El tema principal de la serie «The Best of Both Worlds» fue lanzado como el sencillo principal de Hannah Montana el 28 de marzo de 2006; alcanzó el número 92 en el Billboard Hot 100 de Estados Unidos. Varias pistas de la banda sonora lograron debutar en los Estados Unidos.

«Who Said» fue lanzado como sencillo promocional el 11 de julio de 2006.

Una versión de «Rockin 'Around the Christmas Tree» que aparece sólo como el bonus track de la edición navideña fue lanzada como segundo sencillo el 6 de noviembre de 2007.

«If We Were a Movie» fue lanzado como el tercer sencillo en 2007.

El remix de «The Other Side of Me» fue lanzado como el cuarto y último sencillo del álbum el 10 de febrero de 2009.

Otras canciones
A pesar de no ser lanzadas como sencillos, otras canciones del álbum ingresaron a algunas listas de popularidad. Entre ellas, se destaca a «Who Said» por ser la primera canción de la carrera de Cyrus en entrar al Hot 100, y a «Nobody's Perfect» que logró llegar al puesto #27 luego de ser re-lanzado el disco. A continuación, una lista de las posiciones que estuvieron en algunos conteos:

Promoción

Las primeras actuaciones en vivo de Cyrus fueron durante la gira The Party's Just Begun Tour de The Cheetah Girls en 2006 y 2007. Actuó como Hannah Montana y fue un acto de apertura "rotativo" en lugar de los artistas Vanessa Hudgens, Jordan Pruitt y los grupos Everlife y T-Squad. Más tarde, Cyrus se embarcó en la gira nacional Best of Both Worlds Tour en 2007 y 2008. Sirvió principalmente como herramienta de promoción para el disco recientemente lanzado Hannah Montana 2: Meet Miley Cyrus (2007); [16] sin embargo, «Just Like You», «Pumpin 'Up the Party», «I Got Nerve» y «The Best of Both Worlds» de la banda sonora original se incluyeron en su lista de canciones. La gira resultó ser un éxito comercial, logrando recaudar 54 millones de dólares al final de esta, mientras que su adaptación cinematográfica de 2008 Hannah Montana & Miley Cyrus: Best of Both Worlds Concert recaudó 63 millones de dólares. Este último fue lanzado como un CD/DVD exclusivo de Walmart, titulado Best of Both Worlds Concert, en marzo de 2008.

Recepción

Recepción crítica

Hannah Montana recibió críticas generalmente favorables por parte de los críticos musicales, quienes apreciaron su producción en general. Escribiendo para AllMusic, Heather Phares disfrutó de la entrega de "canciones lindas y bien escritas" de Cyrus, y agregó que el proyecto en general era "dulce, con emoción, [y] absolutamente encantador". Jennifer Axman de Common Sense Media compartió un sentimiento similar, apreciando sus "mensajes optimistas sobre el poder de las chicas" y resaltando a «I Learned from You» como una pista destacada por sus letras inspiradoras ("I learned from you that I do not crumble / I learned from you that strength is something you choose /.../ There is no question that's a lesson I learned from you" —en español: Aprendí de ti que no me desmorono / Aprendí de ti que la fuerza es algo que eliges /.../ No hay duda de que es una lección que aprendí de ti—). MSN Music le otorgó al disco una calificación de 3.5 de un total de 5 estrellas y lo clasificó como un "álbum esencial". Sin embargo, Chris Willman brindó una revisión más variada, comentando que Cyrus parecía "imitar a Avril, Ashlee y Britney simultáneamente" y sintió que el concepto de llevar una doble vida era "una bonita fantasía para Brangelina, pero una extraña para impulsar sobre niñas pequeñas". David Hiltbrand también criticó el disco, afirmando que su "pop genérico" irritaría a los oyentes adultos, pero reconoció que fue "hábilmente ejecutado" para atraer a su audiencia más joven.

Recepción comercial
Durante la semana del 25 de octubre, las proyecciones de ventas iniciales identificaron a Hannah Montana, The Black Parade de My Chemical Romance y Once Again de John Legend como los discos más probables a alcanzar el puesto número uno en el Billboard 200 de Estados Unidos. El 1 de noviembre, Hannah Montana debutó oficialmente en el número uno con unas ventas de 281.000 copias en la primera semana, lo que supone una diferencia de 41.000 unidades más que The Black Parade, que ocupó el segundo lugar. Al hacerlo, el disco se convirtió en la primera banda sonora de televisión en debutar en la posición máxima y la cuarta banda sonora de The Walt Disney Company en debutar entre los diez primeros puestos de la lista. Permaneció en el número uno la semana siguiente con ventas de 203.000 copias. Además, la banda sonora se convirtió en el primero de los cinco álbumes número uno de Cyrus en los Estados Unidos hasta la fecha, seguido de Hannah Montana 2: Meet Miley Cyrus (2007), Breakout (2008), Hannah Montana: The Movie (2009) y Bangerz (2013). Finalmente, la Asociación de Industria Discográfica de Estados Unidos (RIAA) certificó al álbum como disco triple platino por superar ventas de más de tres millones de unidades. Para enero de 2014, Hannah Montana había vendido 3'736.000 copias en los Estados Unidos, convirtiéndose en la segunda banda sonora de televisión mejor vendida, solo detrás de High School Musical (2006) con 4'878.000 copias. A nivel internacional, Hannah Montana se ubicó moderadamente en las listas de éxitos musicales nacionales. Alcanzó el puesto #10 en el Canadian Albums Chart, y fue certificada como disco de oro por Music Canada. El álbum se ubicó en el puesto #23 en la lista Top 100 México, donde luego fue reconocido con certificación de oro. En Europa, la banda sonora alcanzó el puesto #14 en la lista PROMUSICAE de España. Además, obtuvo una certificación de oro en el Reino Unido en tan solo cuatro semanas. En 2014, la banda sonora vendió 3,74 millones de copias en los Estados Unidos.

Reconocimientos

Listado de canciones
Todas las canciones son interpretadas por Hannah Montana, a menos que se indique lo contrario.
 Edición estándar

 Edición especial

 Edición Rusa (Xahha Mohtaha)
Nota: En la versión rusa "Dve ZHizni" es el primer tema porque es la versión rusa de "The Best Of Both Worlds"

Disney's Karaoke Series

Disney's Karaoke Series: Hannah Montana es la banda sonora de la primera temporada de Hannah Montana en modo karaoke, con las ocho canciones de la banda sonora original interpretadas por Miley Cyrus como Hannah Montana. Fue lanzado exclusivamente en los Estados Unidos el 18 de septiembre de 2007.

Listado de canciones

Listas de popularidad

Semanales

Anuales

Década

Certificaciones

Historial de lanzamiento

Notas

Referencias

Bandas sonoras de 2006
Álbumes número uno en Estados Unidos
Álbumes de Walt Disney Records
Álbumes de Hannah Montana
Álbumes de Miley Cyrus
Álbumes en inglés

redpajama_set_name: RedPajamaWikipedia


Stepper Motors works in different "Step Modes" which includes Full Step, Half Step and Micro Step and Wave Drive. The type of step mode output of any stepper motor is dependent on the design of the driver.
Standard Hybrid Stepping motors have 200 rotor teeth, or 200 full steps per revolution of the motor shaft. Dividing the 200 steps into the 360° of rotation equals a 1.8° full step angle. Normally, full step mode is achieved by energizing both windings while reversing the current alternately. Essentially one digital pulse from the driver is equivalent to one step.
Half step simply means that the step motor is rotating at 400 steps per revolution. In this mode, one winding is energized and then two windings are energized alternately, causing the rotor to rotate at half the distance, or 0.9°. Although it provides approximately 30% less torque, half-step mode produces a smoother motion than full-step mode.
Microstepping is a relatively new stepper motor technology that controls the current in the motor winding to a degree that further subdivides the number of positions between poles. Some microstepping drives are capable of dividing a full step (1.8°) into 256 microsteps, resulting in 51,200 steps per revolution (.007°/step). Microstepping is typically used in applications that require accurate positioning and smoother motion over a wide range of speeds. Like the half-step mode, microstepping provides approximately 30% less torque than full-step mode.
In this drive method only a single phase is activated at a time. It has the same number of steps as the full step drive, but the motor will have significantly less than rated torque. It is rarely used.
A stepper motor system consists of three basic elements; Indexer , Driver and a Step Motor.
Indexers - The indexer (or controller) is a microprocessor capable of generating step pulses and direction signals for the driver. In addition, the indexer is typically required to perform many other sophisticated command functions.
Drivers - The driver (or amplifier) converts the indexer command signals into the power necessary to energize the motor windings. There are numerous types of drivers, with different voltage and current ratings and construction technology. Not all drivers are suitable to run all motors, so when designing a motion control system the driver selection process is critical.
Stepper Motors - The stepper motor is an electromagnetic device that converts digital pulses into mechanical shaft rotation. Advantages of step motors are low cost, high reliability, high torque at low speeds and a simple, rugged construction that operates in almost any environment. The main disadvantages in using a stepper motor is the resonance effect often exhibited at low speeds and decreasing torque with increasing speed.
-Permanent Magnet Stepper Motor: It uses a permanent magnet to operate. It is a low cost and low resolution motor. It also exhibits better torque characteristics than other types of motors.
-Variable-Reluctance: This is most easy to understand and most old form of stepper motor. It consists of rotor teeth that become magnetized when attracted to energized stator poles.
-Hybrid Stepper Motor: It is more costly than any other type of stepper motor and also it yields the best results. It combines the best features of both PM and VR motors to operate. It has teeth rotor like VR and magnet just like permanent magnet step motor.
Robotpark, Robot Shop and Store, Robotic Technology Center.


Submissions are to be moving-image, computer-generated new media art that is representative of the experimental, critical and interrogative nature of this burgeoning medium. Sound and physical materials will not be supported at the installation.
A submission fee of $10 must be paid for the applicant to be considered. You may submit more than one work but the submission fee will apply each time. The winner of the Award will be announced at the beginning of the screening. They will also receive a cash prize of $415 (no need to be present to accept the award).
The Award Exhibition will take place Friday, May 17th at 9:06 PM following Andrew Benson's site-specific projections in the courtyard of the Phoenix Hotel during the ArtSlant Afterparty at ArtPadSF. Top submissions to the Award contest will be projected onto the wall adjacent to the Phoenix Hotel (shown above) and viewable in virtual exhibition on ArtSlant.com following the installation. We will also be putting top submissions throughout the submission period on our tumblr.
An error 415 is the HTTP response status code for an unsupported media type; the award refers to new media practices which have yet to be fully supported by the art establishment. We are proud to present the first iteration of this award in the tech-savvy Bay Area.
Anthony Antonellis --> is a visual artist, educator and administrator of netartnet.net. He is known primarily for his work online, but his practice is not limited to virtual space. His process copy-pastes between analog and digital states, exploring the simultaneity of real and virtual objects. His recent works have experimented in short animation, installations, painting, and internet based art. Antonellis studied at Savannah College of Art and Design, BFA in painting, and Bauhaus-University Weimar, MFA in new artistic strategies.
Nick Briz --> is a newmedia artist, educator and organizer based in Chicago IL. His work has been shown internationally at festivals and institutions, including the FILE Media Arts Festival (Rio de Janeiro, BR); Miami Art Basel; the Images Festival (Toronto, CA) and the Museum of Moving Image (NYC). He has lectured and organized events at numerous institutions including STEIM (Amsterdam, NL), the Museum of Contemporary Art Chicago, Marwen Foundation and the School of the Art Institute of Chicago. His work is distributed through Video Out Distribution (Vancouver, CA) as well as openly and freely on the web.
Manuel Fernández --> is founder and curator of Domain Gallery a web based gallery focused on digital and internet based works. His works have been featured in multiple outlets, including spanish newspaper El País, trend magazine Notodo, Triangulation Blog and Minus Space Blog, New York, among others.
Daniel Rehn and Sarah Caluag (me+Sarah) --> are collaborative artist-researchers who have most recently exhibited at MOCA (Los Angeles), Ars Electronica (Linz, Austria), and Electric Picnic (Stradbally, Ireland). Their work can also be viewed at Z/Z/Z/, an online database for animation/cinema/game-based visualizations. They frequently curate together, including exhibitions at ANI GIF (an online gallery that they co-founded) and the upcoming LA Game Space (where Rehn is Executive Director and Caluag is Creative Director).
Annie Werner is the Arts Evangelist at Tumblr, where she works to build and engage the arts community both online and off. In the 2 and half years she's worked there, she has lead projects such as Moving The Still: A GIF Festival during Art Basel Miami and The World's First Tumblr Art Symposium with Hyperallergic. She edits Tumblr Open Arts (tumblropenarts.tumblr.com) where you can find the latest from artists and art happenings on the platform. Annie studied New Media and Public Discourse in Gallatin at NYU. She was born and raised in Texas.


If you are searching to add a deck to your property, The Deck Contractors in Woodbine, New Jersey would be delighted to speak with you. As a deck builder around Woodbine, NJ, we have an extensive selection of various kinds of wood, which will give your deck the specific appearance you have always dreamed of. Additionally, our deck construction company around Woodbine will help you determine which type of wood is ideal for the construction of your deck during our free consultation. Do not wait to contact one of our deck builders at 888-408-0230 now to reserve your cost-free price quote or to ask any questions you might have concerning our substantial variety of deck materials in the Woodbine region.
When you are looking for the deck building materials to be employed in the manufacturing of your new deck, you must ensure they are high quality. A few deck builders around the Woodbine, NJ area have obtained a reputation for having sparkly "wood" on their showroom floor to attract people like you but the the fact is that it is oftentimes faux. At our deck installation company, we prefer to steer clear of this scheme, which is why we only buy the highest quality of genuine wood. Consequently, you can count on receiving several decades' worth of use instead of a few years out of your deck. As soon as you call The Deck Contractors, you will have the an opportunity to talk to our deck builders to find out more about the quality of wood we use.
When you contact our deck construction business around Woodbine, NJ, we will do whatever it takes to help you select the perfect materials for your deck. We will discover more about what you would like your deck to look like and we are going to utilize this information to spot the kind of wood that will generate that look. Furthermore, when you shop at our company, you will never have to be concerned about not having enough money as we have several options for every customer's budget. Following the ordering of the materials to be used for your deck, our deck contractors will assist you to pick an appointment time that works wonderfully for you. Our deck builder team will also make sure that your deck is installed at the earliest opportunity so you do not have to wait long to exhibit your new addition to your friends and relatives.
If you are considering adding a deck to your residence in the Woodbine, NJ area, The Deck Contractors will make the process extremely easy. Our deck builders provide the highest quality products at the most affordable prices. Additionally, we work tirelessly to make sure that the deck assembly procedure goes as quickly and smoothly as possible so you can get started enjoying your house's newest addition. Do not wait to get in touch with a deck builder from our business at 888-408-0230 right now to find out how we can make your dreams become a reality.
What Do I Need to Expect to Spend on Deck Materials in Woodbine, NJ?
With regards to identifying the cost of deck materials, we must determine how much wood you are ordering in addition to the kind of wood. However, our Woodbine, New Jersey deck installation firm provides affordable pricing on every single form of wood we stock, which means we can work with any size of budget.
Which Deck Materials are Ideal for Me in Woodbine, NJ?
When you observe our massive variety of deck materials within Woodbine, NJ, you might feel like you do not know how to start. Part of you is looking for the most resilient materials while the other part is telling you that you want to spend as little as you possibly can. Luckily, our deck contractors will speak with you about how you want your deck to look and provide you with different kinds of woods that fit that image and stay within your budget. Be sure to give our deck builders from The Deck Contractors a call at 888-408-0230 if you want to find out about our various options that will easily fit within your budget. Furthermore, it's worthwhile to have a look at various other towns and cities like, deck construction South El Monte, CA to find out if we offer services where you live.
Can You Mount My Deck in Woodbine?
Yes, our deck contractors in Woodbine would be thrilled to mount your deck. If you let us handle the deck installation, we can guarantee that we will show up in a timely manner and to make the deal even more satisfying, we will have your deck assembled in the quickest manner. All you need to do is to count down the small number of days until you are able to enjoy your deck.
When analyzing the amount of time necessary to have your deck installed, we look at the style of the deck as well as the dimensions. Typically, we can have a deck installed in one week. With that in mind, we will never rush through the installation procedure because we do not want your deck to fall.
Our deck contractors acquire lots of instruction and they have worked in the industry for many years. Their instruction and knowledge are what has enabled us to supply the highest degree of service in the deck installation business.
Yes, most towns require you to have a building permit when adding something on to your residence and a deck is no exclusion. The good news is that if you allow our deck builders to set up your deck, we will obtain it ourselves.
Do You Carry Deck Installation Certification and Insurance in Woodbine?
Certainly, we have the mandatory accreditation and insurance protection for deck installation in and around the Woodbine vicinity.


A seemingly normal detention in a seemingly normal modern day comprehensive. A teacher valiantly battles on with biology revision. She believes only education will set her pupils free . . . because outside the world is in the middle of a long and bloody war.
Despite all her best efforts, too soon the tide of conflict is lapping at the school gates and, one by one, pupils and teacher are pulled under as their hopes and dreams float away from them.
But as she has taught them in her biology lesson, just like a cockroach, only the fittest will survive. She is no longer sure, however, if tenderness and humanity stand a chance.


(a) To create a new page for your website, click on "Content" in the black toolbar.
(b) You will now be able to view all content pages on your website.
(c) Locate and click on the blue "+ Add Content" link to create a new page.
>>> Another way to add content to your website is by clicking the Add Content link in the gray toolbar. This link takes you directly to the Add Content page.
(d) On the Add Content page, you are presented with many options. If you are interested in creating a regular content page, select Basic page by clicking on the link or arrow.
(e) Title your page. Your web page's title should reflect the content and purpose of your page.
(f) Type your page's text in the "Body" and use the WYSIWYG editor (section 2.5) to style your text, and add images and links.
(g) Once you are satisfied with the information in your page's body, scroll down to the bottom of the page and select the Save button.
(h) After clicking Save, you are brought to the View/Edit page where you can view your new content page. You can also click the Edit tab to resume.
Note: There are special considerations for copying and pasting text from a Microsoft WordTM document, email, or another web page into the WYSIWYG Editor.
When formatted text is copied and pasted into your new content page, it can unintentionally introduce HTML code.
Copied and pasted text impact letter, word, and line spacing.
Instead, please copy and paste the desired text into a basic text editing program that will strip out formatting and extra code that you might not see.
Notepad is a basic text editor available on any machine running Microsoft WindowsTM. It can be found in the Accessories folder of the Programs or All Programs menu. If you are working from an AppleTM computer, TextEdit can be used (you must select Plain Text mode in the Program Settings).
Once the text is in Notepad, you can safely copy and paste it to your new content page, and then use the WYSIWYG editor to change text size and style as needed.


Chip Somodevilla/Getty Images(WASHINGTON) -- The Federal Reserve proposed new rules Thursday that require banks maintain stronger capital buffers to protect themselves against potential losses.
The rules call for large banks to hold six percent of their assets in capital reserves, compared to the current requirement of four percent. The proposed rules additionally finalize market risk capital requirements through the implementation of Basel 2.5.
Federal Reserve Gov. Daniel Tarullo lauded the proposed rules, saying they "mark an important milestone on the road to a set of strong complimentary capital standards for banking organizations." Tarullo said that, generally, "pre-crisis capital requirements had been too low" and stressed the importance for banking institutions to have strong capital buffers in place.
"Banks with a strong capital provision can absorb losses from unexpected sources, whether an external shock to the economy, the insolvency of important counter parties or a failure of risk management within the firm. Strong capital buffers help ensure that losses are born by shareholders of the bank not by taxpayers," Federal Reserve Gov. Daniel Tarullo said. "Uncertainty about the capital positions of large financial firms was a major factor in the turmoil that beset the country in the fall of 2008. The subsequent increases in capital at our major banks along with the information provided by the stress tests in 2009 were important factors in stabilizing the system."


Someone had to put an end to the seated-vegetable-clipping hype. Things were getting out of hand.
All I wanted was a bowl of potato clips.
And don't even THINK about plucking that chicken until after take off.
You apologise for the convenience.
Can I sit on vegetables? I promise I won't clip.
But wait, there's more! The Popiel Clip-O-Matic can turn these ordinary carrots into weapons of mass destruction. In seconds. Onion rings? We got 'em.
– Sit! Roll over! Clip!
Every time a date wanted to take me to her church it usually turned into something like this.
Looks like somebody's been circumcising the carrots…. again.
to clip them after a shower.
I'll just cut the cheese then.
But I need to reload my Potato Gun… in case I don't like the performance.
you to PETOV: People for the Ethical Treatment Of Vegetables.
How about the vegetables Mr Abbott?
Just tell them to vote with the party, and keep their mouths shut.
The sound of a carrot in extremis.
Don't you hate that? You're trying to enjoy a good show, and some jerk behind you is snapping the heads off broccoli. So annoying.
On the night of the Taiwan horror, the Brocolli eats you.
But its ok to sit and clip your nails.
Can I just sit and spin?
Can I clip ,my bird's wings instead?
If I can't clip 'em, can I dip 'em?
Just sit anywhere. Except this row. Anywhere at all. But not on the seat. Really, anywhere.
Please don't be seated . . .


Atlantic Webworks is pleased to provide the WordPress platform as a content management option. Perfectly suited for startups, small businesses, and nonprofits, WordPress offers a wide range of templates (themes) which may be customized to your brand. Wordpress sites are search-engine friendly, responsive, and feature an easy-to-use administrative panel for making website updates.
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Hello techies! Today we are here to discuss about the new smartphone launch by Realme after the successor of its Realme 2 and 2 Pro. Here we discuss latest expected leaks, features and launch dates according to new press releases. This smartphone is expected to set up good competition for Redmi Note 7 Pro For more details, go through the article.
If we look for its varients according to leaks we found that this device come across 4GB/32GB and 64GB of storage. Whereas, the another is of 6GB/64GB but if we look toward Realme 2 pro there they provide storage upto 128 GB which may also seen for the 3 Pro. launch dates are not confirmed yet but there is a hope that Realme announces its device in the 3rd week of April may be on 22 April onwards which is expected yet.
Friends! About design there is no 100% confirmation here. But, Realme said that there should be less bezels around the corners in comparison to Realme 2 Pro. Along this it comes 6.3 inch display with tear drop notch. whereas, the backside of the smartphone comes with glass back finish which makes it quiet impressive for the buyers. It also includes a 3.5 mm audio jack, C-type charging port and a fingerprint Sensor.
It is confirmed that Realme 3 Pro comes with Snapdragon 710 chipset and 616 GPU. If we compare it with 675 it is better whereas, in 675 the GPU is 612. So, the graphical experience is much better in terms of gaming. Apart from this the Realme 3 Pro comes with 6 GB of RAM and 64 GB which is expandable upto 256 GB with memory card. More details like benchmark scores and other differences about it we should share after launch.
According to the leaks, this smartphone comes with Sony IMX 519 camera sensor. Possibly it comes with 16+5 MP dual camera setup. Front facing camera comes with 24 MP as media leaks tell us. In Realme 3 pro it is expected to be improvement in pixel size upto 4616 x 3464 Pixels .It supports different modes like continuous shooting, Auto focus and HDR. The sensor used in camera is Exmor-RS CMOS Sensor which optimizes automatically image quality according to the capture conditions. It is also expected that camera also comes with AI feature support.
Finally if you look towards battery, It comes nearly about 4,500 MAH battery which really provides backup for many hours. It is confirmed by the company that Realme 3 Pro comes with VOOC 3.0 charging which means instead of 10 watt charger there we have a 20 watt of charger which is really fast. It takes 60 Minutes to charge 70 to 80% of battery which is another good thing about this device.
Its expected price range starts from the base varient is 13,999 INR which goes upto 17,999 INR for the premium most varient of this segment. so, overall friends, according to leaks we were really excited for this device as it comes with snapdragon's 710. By the way how the color os works for this particular specifications is the main thing to observe. If you're looking for buying a new smartphone please wait for some days and buy this device it really worth's your money. Stay tuned for hands on review of this device we must update you soon.
Thanks for your feedback we always appreciate it!!


There is no better gift for Mother's Day than taking the lessons and traits the mother in your life taught you and applying them to your every day life. Flowers are great, but listening is better.
This week, Brian Flores shared the priceless lessons he's learned simply by being raised by his mom, Maria.
In an ESPN story from earlier this offseason, Brian talked about how his mother kept him and his four brothers in line living in the Brooklyn neighborhood of Brownsville. With high rates of crime, poverty and unemployment, Brownsville was a tough place to grow up. Though Brian loved his community in spite of its reputation, Maria still found ways to protect her sons from falling in with the wrong crowd.
And, as it turns out, Maria taught Brian what true strength looks like.
During media availability with coaches on Friday afternoon, Brian was asked what lessons he learned from his mother, and the first thing that came to mind was toughness.
"My mother's the toughest person I know. She's actually battling cancer now, and she's just… she's just... it's like it doesn't faze her at all," Brian said. "She just gets up every day and tries to – she's beating it. She says, 'I'm beating this. This is a non-issue.'"
Despite her diagnosis, Maria maintains her tough-as-nails demeanor that influenced Brian throughout his life, he said.
"She's as tough as they come. That's one thing I feel I've taken from her that's helped me in all walks of life: personally, professionally. I'm soft on my kids, [but] she wasn't soft on me," he said with a laugh.
Being strong and hopeful in the face of adversity is not easy, but when you have someone leading by example like Brian does, it becomes second nature.


text:
Men's soccer advances to College Cup
Men's soccer team finished their season with a 16-4-4 record, a 5-1-0 league mark, and a ninth West Coast Conference championship.
The Santa Clara's men's soccer team enjoyed another successful season, finishing with a 16-4-4 record that included an appearance in the 2003 College Cup, a 5-1-0 league mark, and a ninth West Coast Conference championship.
Head coach Cameron Rast was named the league's 2003 Coach of the Year, becoming the first person ever to win individual playing and coaching honors in league history. He was twice named the WCC's Defender of the Year during his playing days.
In addition to Rast's accolades, Will Weatherly, Steve Cronin, and Ryan Cochrane all earned All-WCC first-team honors. Freshman Erik Ustruck garnered second-team all-league accolades. Sophomore Kelechi Igwe earned a spot on the All-WCC honorable mention squad.
The Broncos advanced to the NCAA tournament for the 14th time and were among the final four teams, despite playing most matches without Cochrane and Cronin, who left the team due to commitments with the U.S. Under-20 National Team that participated in the FIFA World Youth Championships in the United Arab Emirates.
The Broncos dropped a 1-0 double-overtime match to eventual champion Indiana at the College Cup in Columbus, Ohio. The women's soccer team was ranked third in the country when its season ended with a 3-0 loss to top-seeded and undefeated North Carolina in an NCAA quarterfinal match.

redpajama_set_name: RedPajamaCommonCrawl


If your garage's gutter system is clogged with leaves, twigs, and other debris, clean it out by completing the following steps. Once the gutter system is clog-free, water that is collected inside of it when it rains will be deposited away from the garage. As long as you maintain the gutter sections, they will not become clogged again and your garage will be protected from damage that is associated with pooling water.
Put on a pair of work gloves and carry a small bag up a ladder that is located near the gutter system. Use a handheld rake to loosen leaves, sticks, and any other debris that is located in each gutter piece's interior. Insert the end of the tool in each area that requires cleaning. Grasp the handle and pull it towards yourself. If pieces of debris are stuck to the gutters, wedge the tip of a putty knife under each one to help loosen them.
Add a small amount of industrial-strengthened detergent to a bucket of water. Mix the components inside of the bucket until sudsy. Dip a scrub brush into the cleaning solution to remove any stains that are on the gutter pieces. Insert a tube brush that has been dipped into the solution into the opening of the downspout to clean its interior and dislodge any materials that are stuck. Rinse all sections of the gutter system with a steady stream of water.
Inspect the edges of each adjoining gutter piece. If water is dripping out of any of them, they are not sealed properly. Insert a tube of epoxy sealant into a caulk gun. This product is waterproof and will prevent water from leaking while it rains. Squeeze a line of sealant across any portions that were previously leaking. The product requires several hours to dry. Once this occurs, the gutter system will work the proper way.
To prevent clogs in the future, inspect the gutter system from time to time, especially after heavy winds or severe storms. Remove any debris that is present from each piece. Spray the gutter pieces with a strong stream of water. These simple steps will help keep the system in order so that it continues to work properly.
For professional gutter cleaning, contact a business such as Mr. Gutter.


Coca-Cola Enterprises Inc, markets, distributes and produces bottled and canned beverage products for The Coca-Cola Company. For the 6 months ended 7/1/05, revenues increased 3% to $9.32B. Net income increased 23% to $379M. Revenues increased volume in the European territories and a strong performance for regular soft drinks. Net income also reflects an increase in margins, and a decrease interest expenses as percentage of sales.
Coca-Cola Enterprises Inc. is engaged in marketing, selling, manufacturing and distributing non-alcoholic beverages. The Company is a wholly owned subsidiary of The Coca-Cola Company. The Coca-Cola Company owned approximately 36% of the Company's common stock at December 31, 2004. Coca-Cola Enterprises sold approximately 42 billion bottles and cans (or two billion physical cases) throughout its territories during the year ended December 31, 2004. The Company's bottling territories in North America are located in 46 states in the United States, the District of Columbia and all 10 provinces of Canada. Its bottling territories in Europe consist of Belgium, continental France, Great Britain, Luxembourg, Monaco and the Netherlands. The Company manufactures most of its finished products from syrups and concentrates that it buys from The Coca-Cola Company and other licensors.
Coca-Cola Enterprises is a Fortune 500 company. In 2010 Coca-Cola Enterprises was ranked number 113 on the Fortune 500 list, making it the 113th largest company in the United States when judged by revenue.
Coca-Cola Enterprises achieved revenue of $21,645.00 million in 2010 and earned a profit of $731.00 million.
The company ranking improved in 2010, moving up the Fortune 500 list to 113th compared to 116th in 2009. This was based on its 2009 revenue of $21,807 million (a change of 0 million compared to 2010) and profits of $-4,394 million (a change of $735 million compared to 2009).
To many investors, profits are more important than the revenue a company earns. If the Fortune 500 was ranked by profits instead of revenue then Coca-Cola Enterprises would be ranked 173rd rather than 113th due to its profits of $731 in 2010.
Next Page: the 114th ranked company Bristol-Myers Squibb Co.


text:
Q: Индексация списка списков L = [[[1, 2, 3, 4, 5, 6, 7, 8, 9, 10], [11, 12, 13, 14, 15, 16, 17, 18, 19, 20]],
    [[21, 22, 23, 24, 25, 26, 27, 28, 29, 30], [31, 32, 33, 34, 35, 36, 37, 38, 39, 40]],
    [[41, 42, 43, 44, 45], [46, [47, 48], 49, 50], [51, 52, 53, 54, 55], [56, 57, 58, 59, 60]],
    [61, 62, 63, [64, 65, 66, 67, 68, 69, 70, 71], 72, 73, 74, [75, [76, 77, 78], 79], 80],
    [81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100]]

Из приведенного выше списка списков выведите с помощью индексов число '7'.
Не понимаю, то ли во входных данных ошибка, то ли что-то не усвоил.
Пробовал и 6 и 7 индекс подавать и срез, выводит все, что угодно, но не 7
L['7']
L[0:1]
(L.index(6))
print(L.index('7'))
L[0:6]

A: можно сделать так:
L = [[[1, 2, 3, 4, 5, 6, 7, 8, 9, 10], [11, 12, 13, 14, 15, 16, 17, 18, 19, 20]],
    [[21, 22, 23, 24, 25, 26, 27, 28, 29, 30], [31, 32, 33, 34, 35, 36, 37, 38, 39, 40]],
    [[41, 42, 43, 44, 45], [46, [47, 48], 49, 50], [51, 52, 53, 54, 55], [56, 57, 58, 59, 60]],
    [61, 62, 63, [64, 65, 66, 67, 68, 69, 70, 71], 72, 73, 74, [75, [76, 77, 78], 79], 80],
    [81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100]]

def found_in_list(arr, value, index = []):
    for obj in enumerate(arr):
        index_new = index + [obj[0]]
        if type(obj[1]) == list:
            found_in_list(obj[1], value, index_new)
        else:
            if obj[1] == value:
                print(index_new)

found_in_list(L, 48)

redpajama_set_name: RedPajamaStackExchange


What's it like to be really poor?
More than 3 billion people live on less than $2.50 a day and an estimated 1.3 billion live in extreme poverty, making do with $1.25 or less daily.
Can you imagine what it's like to not have enough food to eat and go to bed hungry at night?


The contest was attended by designers from 60 countries from every continent. Works of the contestants were evaluated by 50 influential representatives of the world of design from 14 countries: journalists, architects and designers.
01 December, 2018 DEADLINE IS EXTENDED!


Just 90km long, the Nidd gets its name for the Celtic word for brilliant. It rises at Nidd Head Spring on the slopes of Great Whernside in the Yorkshire Dales, 595m above sea level. In its first few miles it is dammed three times to create Angram Reservoir, Scar House Reservoir and Gouthwaite Reservoir where compensation flows are released.
The classic pool and riffle upper reaches support good stocks of Brown trout and Grayling. The Nidd can overflow the reservoirs, flooding the caves in the valley in which case the river then flows along the normally dry river bed past Lofthouse through to Gouthwaite Reservoir.
It flows through Pateley Bridge and Knaresborough before going on to join the River Ouse at Nun Monkton near York.
The main issues on the River Nidd are rural pollution , physical modification, mine pollution, changes to flow and pollution from wastewater.


text:
Breen Lab
Seaver Autism Center
Breen Laboratory
Laboratory of RNA editing and rare neurodevelopment disorders
A-to-I RNA editing in the CNS
Rare developmental disorders and RNA therapeutics
Laboratory of A-to-I RNA editing and rare neurodevelopment disorders
Our research is dedicated to RNA editing and genetics/genomics of rare neurodevelopment disorders. We combine methodologies across human genetics, computational biology, molecular biology, and cellular neuroscience. We have three main research foci:
1. We pioneer state of the art genomic investigations of monogenic neurodevelopment disorders.
2. We develop oligonucleotide-directed RNA editing therapeutics to treat these disorders.
3. We leverage large-scale transcriptomics to dissect RNA editing function and regulation in brain development, disease and aging.
LAB CULTURE AND PHILOSOPHY: In our lab, we prioritize and promote a healthy work/life balance as well as a positive, promotional, inclusive, respectful and productive lab culture. My primary focus as a mentor is to train, motivate and inspire the next-generation of academic and industry scientists – everyone's journey is different! Ultimately, my ambition is for each member to make a positive scientific impact and to grow professionally through rigorous, ethical and highly original science and outreach. We work as part of a diverse cross-functional team of computational and experimental biologists. We also function as part of a highly collaborative environment in the Seaver Autism Center for Research and Treatment at Mount Sinai, the MINDICH Child Health and Development Institute and the Depts. of Genetics and Genomic Sciences and Psychiatry.
RESEARCH TOPICS: adenosine-to-inosine editing, mRNA secondary structure, brain development, autism spectrum disorder and syndromic subtypes, schizophrenia, neurodegeneration, aging, immunogenetics of developmental disorders, human genetics, gene and protein expression, alternative splicing, quantitative trait loci.
GENOMIC TECHNOLOGIES AND METHODS: WGS, WES, DNAm arrays, transcriptomics (single-cell RNA-seq, RNA-seq, long read isoform-sequencing), mass spectrometry proteomics and metabolomics, multi 'omic' computational models and tools, CRISPRi, fluorescence activated cell and nuclei sorting, cytometry time of flight, neuronal culturing, antisense oligonucleotides, hiPSC-derived neurons and neuronal model systems.
Michael S. Breen, PhD (he/him)
I am the Principal Investigator of a terrific team specializing in human genetics and genomics, computational biology and cellular neuroscience. In 2008, I joined the Center of Genomic Regulation (Barcelona, Spain) as a Scientist where I developed statistical methods to measure epistatic interactions and their influence on complex traits. Later, I received a PhD in Genomics and Bioinformatics from the University of Southampton (United Kingdom) investigating epigenetic and transcriptomic mechanisms underlying a range of major neuropsychiatric disorders. In 2016, I started postdoctoral training in Molecular Psychiatry and Genomics at the Icahn School of Medicine at Mount Sinai. In 2019, I joined the Faculty at the Icahn School of Medicine at Mount Sinai as Assistant Professor and started the Breen Lab in the Departments of Psychiatry and Genetics and Genomic Sciences. Our lab is also a proud member of the Seaver Autism Center for Research and Treatment.
Miguel Rodriguez de los Santos, PhD (he/him)
Contact: miguel.rodriguezdls [at] mssm.edu
Miguel completed his masters in Molecular Biology at the University of Potsdam, Germany, in which he also studied at the University of Rome "La Sapienza", Italy within the ERASMUS exchange program. In his master thesis, he focused on gene editing and on making CRISPR-gene editing more efficient towards homology-directed repair events. Miguel obtained his PhD at the Charité, University Medicine in Berlin, Germany, where he worked on CRISPR-engineered mouse models for rare neurodevelopmental disorders. More specifically, Miguel studied the molecular and behavioral outcomes of patient-specific mutations affecting the GPI anchor pathway in mice. In 2022, Miguel joined the Breen Lab at the Icahn School of Medicine at Mount Sinai as a postdoctoral fellow where he is developing novel mutation-tailored therapeutic approaches for autism spectrum disorder and rare genetic subtypes. Outside research, Miguel loves outdoor sports, politics, food and exploring the city.
Pardis Amini (she/her)
Associate Researcher
Contact: pamin1 [at] unh.newhaven.edu
Pardis is an Associate Researcher in the lab and a second year Master's student with a focus on Cellular and Molecular Biology at the University of New Haven. In 2020 she obtained a Bachelor's degree in Genetics from the University of Shahrekord in Iran. Her interests are focused on medical genetics and genetic disorders, and she has gained both academic industry exposure. She recently interned at REGENXBIO during the summer of 2022 leading research on Duchenne Muscular Dystrophy gene therapy. She joined the lab in September 2022 and is working on antisense oligonucleotide therapeutics for rare developmental disorders. Her long-term ambitions are to enter a PhD program focused on neurogenetic disorders.
Andy Yang (he/him)
Biomedical Sciences Master's Student
Contact: andy.yang [at] icahn.mssm.edu
Andy is a Master's student tin the Biomedical Sciences program and the Icahn School of Medicine at Mount Sinai. He graduated from Crown College in 2022 with a degree in Health Sciences and Medical Biology. In his undergraduate thesis, he focused on identifying potential biomarkers of the senescence-associated secretive in age-associated tumors using bioinformatics. Through his research project, he gained a newfound interest in computational biology and later joined the Breen lab in January 2023 to further his studies in functional genomics. For his research, he is resolving cell type- and isoform-specific RNA editing across the human cortex. In the future, he aims to pursue a PhD in computational biology and to continue on his journey in academia. Outside of research, he enjoys getting lost in music, indulging in good stories, and spending quality time with loved ones over dinner!
Gauri Ganesh (she/her)
Contact: gauri.ganesh [@] icahn.mssm.edu
Gauri is a first year Biomedical Sciences Master's Student at the Icahn School of Medicine at Mount Sinai. She graduated from UCLA in 2018 with degrees in Molecular, Cell, and Developmental Biology and Neuroscience. After spending a few post-graduate years working in industry and academia, she returned to school to explore her interests in neurodegenerative and rare diseases. She joined the Breen Lab in November 2021, and is currently researching RNA hyper-editing events in Alzheimer's disease. In the future, Gauri hopes to either further her graduate education through a PhD program or work in industry.
Ariela Buxbaum Grice (she/her)
Contact: ariela.buxbaumgrice [@] mssm.edu
Ariela graduated from Connecticut College in 2020 with a major in Biological Sciences and a minor in Studio Art. She joined the Breen lab team in October of 2021 and is currently using scRNA-seq approaches to explore cell type-specific differences in gene expression profiles associated with rare syndromic subtypes of autism spectrum disorder. In the future, she aims to attend graduate school and continue research on the -omics of neurological/neurodevelopmental disorders.
Lab Alumni:
Xuanjia (Sinja) Fan was a Research Assistant/Lab Manager and is now attending Medical School at Penn State.
Enrico Mossotto was a postdoctoral fellow and is now leading genomic research in Industry
Joshua Senior was a research volunteer from Brooklyn Technical High School and is now attending University.
Kendall Moore was a SURP student and is currently finishing studies at Santa Clara University studying Neuroscience and Ethnic Studies.
Sarah Zipkowitz was a Research Volunteer and is currently attending Binghamton University where she is studying Biology and Judaic Studies on the Pre-Med track.
Genomics of brain development and neurodevelopmental disorders
Our work pioneers large-scale genomic investigations of human cortical developmental, combing genetics, transcriptomics and proteomics (see here and here). These studies chart the complex spatiotemporal and genetic regulation of gene expression and protein abundance, their functions and timely interactions across fetal and postnatal development. We have also led studies dissecting post-transcriptional A-to-I modifications and their roles in supporting the functional diversity of human brain development (see here). In addition, our lab is part of the Autism Sequencing Consortiums (ASC), dedicated to dissecting the genetic architecture of ASD through large-scale whole exome sequencing and de novo variant discovery (see here). We are also part of the Seaver Autism Center for Research and Treatment at Mount Sinai, where we led a number of studies focused on rare monogenic subtypes of autism (see here a report of transcriptional alterations in hiPSC-derived neurons as a consequence of 22q13.3 sequence variants and deletions in participants with Phelan-McDermid syndrome).
Mapping the regulation and function of A-to-I editing in brain health and disease
Another component of our work is focused on elucidating highly regulated adenosine-to-inosine (A-to-I) editing sites in the human brain both with the main goal to prioritize RNA editing sites for functional, mechanistic, and RNA therapeutic investigation. Currently, we are tackling aspects of RNA editing regulation across brain development (see here), major brain cell types and their genetic regulation (see here) and dysregulation in neurological disorders (see our work in schizophrenia here). We are focused on three central areas:
First, we aim to uncover A-to-I sites implicated in neurodevelopmental and neurodegenerative disorders using large-scale RNA-seq and snRNA-seq from postmortem brain samples and neuronal cell systems.
Second, we seek to examine the functional impact of these RNA editing sites on protein function and cellular phenotypes, and we are specifically focused on sites encoding glutamatergic receptors, ion channels and pumps.
Third, we aim to develop site-directed RNA editing approaches for therapeutic correction of disease-related RNA editing sites as well as therapeutic repair of highly penetrant, rare genomic point mutations at the mRNA level.
Immuno-genetics of neurodevelopmental disorders: biomarkers and treatments
We have investigated the immunobiology of major neurological disorders for the past 10 years (see a few examples here, here, here, here). In the Seaver Autism Center, we are leveraging this expertise to dissect the immunogenetics and immunobiology of children with rare developmental disorders. Our research in the Center surveys peripheral immune responsivity and function in children with rare syndromic subtypes of autism using high-throughput genomic and cellular techniques, including scRNA-seq, metabolomics, proteomics and cytometry by time of flight. This work has uncovered novel immunodeficiencies that underlie recurrent infections in rare disorders that are typically studied in the context of the central nervous system, thereby providing avenues for biomarker development and new therapeutic interventions to tackle common immune-related phenotypes. Our work has also described novel molecularly defined genetic subtypes in both ADNP syndrome (see here) and Phelan McDermid Syndrome (see here).
Algorithm Development
We are also interested in solving emerging biological and algorithmic problems, which arise from our studies and others, such as: a) comparative transcriptomics and proteomics; b) modelling transgenerational effects across generations; c) predicting cellular frequencies from heterogeneous biological tissue; d) multi-modal integrative deep machine-learning applications; e) modelling RNA-editing in from heterogeneous RNA-sequencing data; f) gene network reconstruction and multi-modal omic data integrations. In addition to generating new data in support of these aims, we also use just about any high-throughput data we get our hands on in the public domain, which can ultimately be translated into better understanding biology.
Check some of our Rshiny apps:
Temporal proteomic profiling across postnatal cortical development (see here)
Transcriptional response to glucocorticoid stimulations in PBMCs from warfighters (see here)
Cell type specific transcriptome profiling in umbilical cord blood (see here)
The Seaver scRNA-seq Resource (see here)
The Seaver Autism Center for Research and Treatment
The Breen Lab is part of the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai. The Seaver Autism Center is a fully integrated, translational research center that leads progressive studies and provides personalized care to individuals with autism and related rare disorders. As a team, we are dedicated to discovering the biological causes of autism and developing breakthrough treatments.
As a part of the Seaver Center, our lab is primarily focused on understanding the cellular and molecular consequences underlying rare syndromic forms of autism, including Phelan McDermid-Syndrome (SHANK3), ADNP syndrome, and FOXP1 syndrome. We also collaborate with groups in the Center that generate genetically modified animal models for these genes as well as human iPSC-derived neurons, which we profile using functional genomic tools. Learn more about the Seaver Center here: https://icahn.mssm.edu/research/seaver
Follow the Seaver Autism Center on Twitter:
Select lab publications
Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development. Cell Reports. (2022).
Cellular and genetic drivers of RNA editing variability in the human brain. Nature Communications. (2022)
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience. (2022)
Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype. The American Journal of Human Genetics. (2020).
Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism. Molecular autism. (2020).
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism. Cell. (2020)
Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia. Nature Neuroscience. (2019).
Differential transcriptional response to glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Translational Psychiatry. (2019) .
Large-scale proteomic analysis of human prefrontal cortex identifies proteins associated with cognitive trajectory in advanced age.Nature Communications (2019).
Temporal proteomic profiling of postnatal human cortical development. Translational Psychiatry (2018).
Gene expression in cord blood links genetic risk for neurodevelopmental disorders with prenatal maternal distress and adverse childhood outcomes. Brain, Behavior, and Immunity (2018).
We strive to maintain an open-minded, creative and productive research environment, and we are fully committed to foster the growth and development of trainees in the wet and dry labs. If you are interested in applying for a position, please send the following information to michael.breen@mssm.edu
• Complete curriculum vitae, including a list of publications.
• A very brief summary of current work and research interests.
• Contact information for two references.
Contact: Depts. Psychiatry, Genetics and Genomic Sciences
ICAHN BUILDING 14-26
1425 Madison Avenue, Box 1498


text:
Пло́щадь Введе́нского — площадь на северо-западе города Фрязино Московской области. Почтовый индекс — 141190.

На площади Введенского в доме 1 расположена Администрация Фрязинского филиала Института радиотехники и электроники им. В. А. Котельникова РАН (ФИРЭ). Этот корпус также выполняет роль проходной в институт.

Площадь названа в честь одного из основателей Института радиоэлектроники академика Бориса Алексеевича Введенского (1893—1969). На здании имеется мемориальная доска, посвященная академику Б. А. Введенскому.

По почтовому адресу: г. Фрязино, пл. Введенского, д. 1 находится компания НТО «ИРЭ-Полюс».

28 октября 2009 года во Фрязино, в корпусе ФИРЭ по адресу пл. Введенского, д.1 под председательством Президента России Д. А. Медведева состоялось заседание Комиссии по модернизации и технологическому развитию экономики России.

Площадь с юго-запада и северо-запада огибает проезд Введенского.

Примечания

Фрязино
Улицы Фрязина


Chas and Dave singer Chas Hodges has died, the pair's Twitter account has announced.
The statement reads: 'It is with tremendous sadness that we announce the passing of our very own Chas Hodges.
The 74-year-old had a career that has spanned 45 years as part of comedic musical duo Chas N Dave, with hits including the Snooker Loopy and Rabbit.
Alongside his musical partner-in-crime Dave Peacock, Chas grew up in North London, where the pair met and, in turn, inspired a lot of their music which has since become synonymous with cockney living.
Their debut album, One Fing 'n' Anuvver, was released in 1975. In their career, they went on to have eight top 40 singles, performed at Glastonbury several times, and even opened for Led Zeppelin in 1979.
A massive Tottenham Hotspur fan, the pair dedicated a number of songs in the football club's honour, including Glory Glory Tottenham Hotspur and Hot Shot Tottenham.
The pair continued to perform up until last year, when in February he was diagnosed with oesophageal cancer which everyone hoped he had caught early enough to treat.
Despite the diagnosis, Chas remained optimistic about returning to the stage and had started performing again before passing away in the early hours of this morning.
Chas married his wife, actress Joan Hodges, in October 1966 and together they have three children – Juliet, Kate and Nik.
Kate and Nik have both followed in Chas' footsteps and become singer/songwriters in their careers.
Charlie Hodges, Chas' granddaughter, is a fashion designer, and he also has a grandson, Harry Garner.