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Greetings Cyberfriend!
Yikes! It's been many a moon since we've last written any updates! It's been hectic here in Turtleland, that's for sure! Things got complicated for me when Renet showed up again… with Savanti Romero in tow! But this was a far-flung future Savanti (well… he's still from our past, but far older than I'd ever seen him before). I was in my lab working on the force field generators and having little success. After we had celebrated Christmas together, I was so preoccupied that I hadn't seen much of my family for the first few weeks of 1999. Ireally wanted to get this tech down pat, but it's been resisting me of late. The major source of my problem is, as usual, power supply. Electricity is just too expensive to generate to serve as a viable source of power for the force fields. I've tapped into the City's lines on occassion to try some tests, and it proved that I'd need another power source if I'd ever hope to get things working properly. I apologize for the brief black out that I caused around 57th street that night… heh. Oops! Ah well… Planet Hollywood probably has emergency generators anyway. :)
One night while I was working on the force field problems, Master Splinter, Leo, Mikey and Venus came into my lab and asked me if I wanted to accompany them back to China to meet with some of Venus' old friends, who she knew through her deceased guardian. To be honest, it sounded like something innocuous and… boring. After having visited China a few months back, I was not in the mood for that kind of traveling again. Leo, Mikey and Venus were disppointed, but the Sensei could see that I was preoccupied with my work, and truth be told, I needed some time alone with my inventions. I think Master Splinter could sense that. I took a few weeks off over the Holidays, and I was itching to get back to business. I've seen some of the things I've done in the future (thanks to our bizarre time traveling escapades), and as odd as it may seem, I feel like I'm in a competition with myself to make sure that I accomplish the tasks that I've seen me do (geez… this type of talk gets confusing real fast!) Seeing the future-me was unnerving in more ways than one… if you ever get the chance to meet the future-you, take my advice and avoid it! I really think that the future is best left unknown! I feel all kinds of extra pressures on myself now, and it's only exasperated by my brothers when they make jokes about me loafing around… I don't feel like I have a moment to spare anymore. I guess I should calm down, since the future will be… but then I'm always thinking "But maybe I met the future-me because it served to motivate the past-me". I hate time anomalies!
Anyway, on a later night I was working in the lab (a few days after Splinter and the others had departed), and who should show up but Renet and Savanti! Not who I was exactly hoping to see! I was brooding about time travel as I worked, and then in pops Renet with her Time Sceptre and "companion". Oh brother! The both of them looked more than a little worse for wear. Renet seemed a few years older than she was the last time that we had met, but Savanti seemed to have aged a thousand years. He was a shell of his former self, barley able to move and weighing at least 200 punds less than he once had. If I didn't know better, I'd have felt sorry for him… but knowing how insidious he once was, seeing him in this state was not too surprising. You reap what you sow, and Savanti had never planted anything of value that I know of.
Renet wanted to see Leo right away, but I told her he was gone for a few weeks at least… the only ones around were Raph and I, and Raph rarely came home these days because he was off with the Foot (this news startled her… all she said was "Already?!" and got a very concerned look on her face… not very comforting to see, knowing that she can jump all over the time line and see our future. Who knows what she knew? But I knew better than to ask… I'll find out the old fashioned way and wait and see). Savanti didn't care about Leo or the others, he just wanted me to help them. I think Renet wanted to talk things over with Leo and Master Splinter before proceeding, but oddly enough, we were strapped for time and she couldn't just pop out and come back in a few weeks.
What it boiled down to was that Lord Simultaneous, Renet's "boss", had been captured by some sort of evil time-lord type being known as Dark Lady Thurishtia (DLT from now on… her full name is a real bear to type over and over :). Apparently DLT has been a nemesis of Lord Simultaneous' for countless eons… he was trying to maintain some sort of balance through the timeline while she was striving to exert her chaotic influence over how things went. It turned out that at some point Savanti had gotten her attention and the two had worked together to stop Simultaneous… but of course Savanti had tried to trick her in the process. So DLT had punished Romero through dozens of years of hard labor (so he wasn't actually a thousand years older, he just looked it. This meant trouble, because it indicated that Savanti was only weakened through harsh treatment… and he might revive at any time). As it turned out, Savanti's tactics had been sound, and DLT defeated Simultaneous using his plan. As is usual for Savanti, if he hadn't gotten so power-mad he would have succeeded… but beings of his ilk rarely learn any lessons… Krang and Shredder certainly never did!
DLT had used Savanti's plan to capture Simultaneous in a temporal energy field. Savanti had surmised that a few simple magiks used in combination with DLT's powers could create an energy stasis field that would basically cause a "short" in the time field as Simultaneous attempted to plane shift, trapping him between zones (I think… this stuff was pretty complicated, and Renet and Savanti took turns telling different pieces of the story and spoke so quickly I couldn't keep up very well). What happened was Savanti had planned your basic "I'll get his attention while you zap him" approach, and it worked like a charm. DLT ported SR in, he caused a problem for Simultaneous (casting a few seemingly useless spells while he was there) and then DLT popped him back to her time zone. Simultaneous fell for the bait, and when he attempted to follow SR, DLT sprung her trap and Lord Simultaneous was trapped in the nether realms of time and space. Had Savanti been happy to play second fiddle, the story might end there, except while DLT was casting her own spells to ensnare Simultaneous, Savanti was trying to use his own powers to trap her as well. But DLT is far more powerful than Savanti thought, and his attempts bounced off of her protective spells like water off a duck's back. So she banished him to a prison world labor camp.
Renet was left alone in Simultaneous' castle, and didn't know what to do. Apparently DLT was allowed free reign for at least a dozen of our years… so whatever that might result in is anyone's guess. Renet tried to battle DLT once and was lucky to escape with her life… but her Time Sceptre was damaged in the fight. She tried to round up some help to go after DLT, but she was too late, as part of the Dark Lady's plan was to take out all the secondary powers in the megaverse prior to her assault on Simultaneous… so Renet had no one to turn to for help… except Savanti himself. The evil ex-time lord was her only hope… so she rescued him from the prison world. For some reasn, Savanti decided that I might be able to help… a job that I certainly didn't feel capable of handling! I was having trouble figuring out how to power a force field, what hope did I have in conquering an evil time sorceress?
But of course, Savanti had a plan. If we could just stop him from trying to mess it up, maybe we could be successful…
Unfortunately, we were stuck with a mostly burnt out Time Sceptre… Renet's battle with DLT had damaged it tremendously, and each time she had used it since, it apparently became weaker. Perfect… it's power supply was shot… ugh! It also had become less trustworthy, as Renet had hoped to have arrived in our time at a point before Raph had taken his sabbatical… but she missed by a few months. She told me in secret that she had missed rescuing Savanti by many years, but she didn't want to risk any extra trips with the Sceptre working so poorly, and she was actually more comfortable with him in his weakened state. I can't say I blamed her for that.
So our first job (and the only one SR wanted me part of) was to fix Renet's time stick… I'd been playing around with my own version of one of these awhile back, so I at least had a vague notion of how they operated. The problem was as simple as it sounded, the sceptre was running low on "battery" power… and after spending a few days researching things (boy am I glad Raph never showed up during that time… he probably would have tried to kill Savanti), I finally had my theory. Renet and Romero didn't like my findings one bit…
It turned out the the sceptre was tied directly into Lord Simultaneous himself… as his life force fades, so too did the Sceptre's power. What we had to do was obvious… we had to rescue Simultaneous first, and go after DLT second (Savanti was adamantly against this plan, but we had no choice. He still wasted a few hours of our time with pointless arguments and sulking. The reason he didn't want Simultaneous freed was because he feared the time lord's wrath if/when we rescued him. After our first encounter with Simultaneous, I understood Savanti's fears, but like I said before… you reap what you sow). Without Simultaneous' help, Romero and Renet might be stranded someplace when the Time Sceptre stopped operating. Renet understood what this meant as well… if the Sceptre was to stop working entirely, that would mean only one thing… Lord Simultaneous himself had died.
Fortunately Savanti finally agreed to our rescue plan… his abilities were practically non-existent at this point, DLT's attack and 12 years on a slave-labor world had taken their toll on him. He needed the Sceptre's power more than ever. Alhough it meant facing his oldest enemy in a forced alliance, he knew that it was his only hope to recover any part of his past glory. More importantly to the treacherous ex-time lord, he wanted to exact revenge upon the Dark Lady. The good news was that he knew how to locate Simultaneous… the bad news was we'd need a great deal of magical energy to free him… and we didn't have much. Once again I was haunted by the problems of power supply! It was obvious from how poorly the Sceptre was operating that Simultaneous was fading fast, so we had to move. I volunteered to help them, and despite SR's initial resistance, they agreed to let me accompany them. I wasn't about to let Renet go with Romero on her own… she's a bit goofy, but she is our friend.
Before we departed I'd decided that we'd better try to boost the Sceptre's powers. I know nothing of supernatural "magik", but I know a few things about science. I'd had a notion that maybe I could reverse the field generator on the Sceptre to absorb Savanti's inane magical abilities rather than sapping the ever-weakening Simulataneous. Needless to say, Romero hated this idea, but after talking things over for quite some time, he finally agreed. There was no guarantee that I'd even succeed (and I didn't mention this, but there was a good chance I'd ruin the Sceptre altogether in the effort. But nothing ventured, nothing gained). It was a fairly simple matter of discerning how the Time Sceptre was "grafted" to Simulataneous, it was an ancient artifact and very primitive by other standards. I found an small sampling of an organic substance in one secret compartment of the wand. I analyzed it and was at first totally baffled by what it was, but when I took a blood sample from Renet and Romero, I discovered that it was a small, dehydrated sample of Simultaneous' blood. I learned from Savanti the importance of "blood sacrifice" to the old magic items… but from the amount of blood that Simultaneous had left, I'd say "sacrifice" was a bit of an exagerration. I stuck a pin in Savanti's finger and squeezed a drop of his (very unusually constructed) blood into the Sceptre's compartment. Nothing happened… so I went back to work, analyzing the wand, scanning it and compiling complex 3D computer graphics to explore its interior… and that's when I found the second secret "room". Using the 3D map of the Sceptre and zooming in at a magnification of 100, I saw the true compartment that demanded the blood sample. The problem was, how the devil I was going to be able to open such a miniscule door. Renet said that Simulataneous probably reduced himself and walked in… great… none of us had the ability to shrink to the size of an atom… now what?
Renet suggested that we use the Sceptre's failing power to transform Savanti to the size we needed and have him "install" the sample. That part I thought would work fine, however, I explained to her that once he did that, he might be stuck in the wand, as the Sceptre would be powered by Savati's own strength at that point. Any extraneous action that he took would only serve to weaken both him and the rod, possible exponentially due to his close proximity to the power supply itself. This could short out the wand entirely, and we needed it to be as close to fully charged as possible. She didn't agree with me, as she figured Simultaneous must have done the very thing we were discussing… but I wasn't so sure that the time lord had actually gone in the Sceptre himself. He could have had someone else do it for him. As we discussed this, Romero got impatient, grabbed the wand, invoked a few words of power and disappeared into thin air. The Sceptre bounced around a little bit, so we knew what he had done… after a few moments it started glowing and spinning in mid air. Just as suddenly a low wail started that quickly rose into a horrendous roar. The wand kept spinning faster and faster and the light that it emitted intensified greatly as the noise continued to rise in decibel. I thought we'd go blind from the light and deaf from the noise. I grabbed Renet's hand to get her out of the lab before something horrible happened.
And then all went still.
The wand dropped to the floor and stopped glowing. "Like, wow!" was all I could get out of Renet for several minutes. I waited about 20 minutes before I picked up the Time Sceptre… despite what had just happened, it didn't look any different than it had before. I quickly took it to my apparatus and scanned it… and sure enough, it radiated much more energy at that point. I surmised that Savanti had succeeded in transfering the power-drain to himself… but now we had a bigger problem… as he was the only one who knew where to find Simultaneous! As Renet and I pondered this, the wand began spinning again…
And Savanti appeared out of nowhere and caught the wand in mid-air. He was now fully restored to his former self, and had a wicked grin on his face… "You fools!" he laughed. "I knew that you'd fall for that scheme… but you certainly took your time in doing so! I thought I played my role well, did I not?" Needless to say… Renet and I were taken aback! But then just as suddenly, Savanti transformed back to his weakened state and he started laughing. "Heh heh.. sorry… couldn't resist. Just a little joke…"
I can't say that I enjoyed his sense of humor, but I was happy to see him… especially in his weakened appearance. He said that he'd cast a very minor illusion, and that he didn't know how long his powers would last, as he could feel the Sceptre sapping them with a voracious appetite.
So the next step was to use the Time Sceptre to teleport us to where Simultaneous was being held in stasis. Savanti thought that freeing him from DLT's spells would be difficult, as she was a far greater sorceror than he… but perhaps we'd get lucky. I had a good idea that we would. Savanti handed the Sceptre to Renet and began an incantation. She held the wand above her head as the room started spinmning and some became a vortex that engulfed the three of us.
…blackness …
It stretched towards infinity in all directions. Somehow, I have no idea how, I could see Renet and SR fine. Renet later explained that I was viewing their auras… but I've seen plenty of auras and they've never revealed stark details before… but who am I to argue? It was definitely my first trip to the netherzone between time and space. Simultaneous was nowhere to be seen. "We're here." Romero said, a wicked smile creasing his lips… I was ready for another trick or bad joke, but none came. I suppose he was nervous, becasue he would soon be trying to free his mortal enemy… who he had help ensnare.
"Which way?" I asked… I couldn't see anything anywhere.
"No way. We're, like, already here. There is no 'way' here. We're just here, y' know." Renet stated.
"So where's Lord Simultaneous?" I asked. And no sooner had the last syllable left my lips than he was there… he appeared to be floating right in front of us, although we all had apparent solid footing. He also appeared to be unconscious…
"You try to wake him with the wand… I'll try to break Thurishtia's spells. We must do this quickly, and forgive the pun, simultaneously. The powers of the Scpetre are both weakened and strengthened here, and I know not what will happen when we try to use its powers while I attempt to use my own."
With that, Renet nodded and commanded the Sceptre to awaken Simultaneous at the same instant that Romero started several spells, wildly gesticulating. And then we all froze, immobile, but aware of our surroundings. I guess Savanti's mouth had been frozen open, because I heard him gurgle with fear as a figure approached from the distance.
She was the most beautiful woman that I've ever seen. Clad in a full-length black leather gown with a high collar and a long flowing cape made of something that seemed to be alive, as it moved with its own purpose, rather than from wind current or gravity. In her left hand she carried a staff made of an obsydian mahogany… carved in the form of a long snake. It's jeweled eyes gleamed with a fiery life. Her face was as pale as porcelain and set off starkly from her all-black garb. Her lips were bright crimson and her large eyes were both alarmingly warm and icy cold at the same time. Her long hair was pulled back tightly against her skull, and cascaded down her back with black tendrils. If Mikey had been here to say it, she would best be described as "awesome"… but I was thinking more along the lines that she looked like an executioner rather than a dark angel.
"Ah, Savanti dear. You're looking… interesting. I see a few years of hard labor and minimal talent has not stilled thy treacherous heart. I'll always admire that in you, dear child." She was creepy, alright. She approached Romero as she talked, and stroked his cheek, almost remorsefully. He couldn't move a muscle, but sweat began pooring down his forehead. I admit that I felt sorry for him at that moment.
She turned from Savanti and snapped her fingers, and he was gone. Where she sent him I had no idea, but from the look of terror in his eyes, I'm sure that it wasn't anyplace good. She then turned on Renet and snatched the wand from her grasp. "Truly astounding how children's toys can so often trip elders…" Thurishtia mused as she turned the Time Sceptre over in her hand. "I sense that this has been attuned to our dear Savanti… not bad, turtleman" with this she addressed me and then walked over to face me. I was worried, but I can't say that I was afraid of her. Something in her eyes was telling me not to be frightened, although her grim smile spoke volumes otherwise. "These are matters that you should not concern yourself with, turtleman. You have other destinies and other talents… I advise you to trouble yourself no more with magiks… you don't have the stomach for it." With that she broke the Time Sceptre in half, and we all heard a howl of pain and fear from a distance… there was no doubt that it had been Savanti making the cry.
I tried to focus, to center myself, so that I might b able to move. I didn't know what I might do, but I knew I had to do something… but all of my efforts were for naught. I hate the supernatural more than anything. It doesn't make sense.
Dark Lady Thurishtia then walked back to Renet. "What to do with you, child?" she thought as she tapped her forefinger against her chin. As she started to snap her fingers an old, vaguely familiar voice rang out.
"That's quite enough, mother." it said in a loud booming voice that I remebered as Lord Simultaneous. Suddenly I was half-freed… Thurishtia's attention was quickly and drastically diverted. I could turn my head just enough to see that Simultaneous was free… whatever Savanti and Renet had managed to do before DLT showed up, it had been enough. I had the idea that if we removed the Sceptre's power drain from Lord Simultaneous, perhaps it would grant him the extra boost in power that he'd need to break free. Perhaps all three of our efforts had worked. Simultaneous was standing with his arms crossed, and was almost glowing with anger. "I never thought you would stoop so low, mother… killing father was bad enough, but trying to slay me is simply unforgiveable".
From that point things got loud, bright and nosiy again. A huge magical battle ensued that I could only see through my peripheral vision, as I didn't yet have full control of my motor functions. No further discussion was made… apparently Thurishtia had said all she had to say to Simultaneous in the past. After what seemed an eternity, I suddenly fell to my knees… I could move again! Renet was by my side and she helped me to my feet. Both Simultaneous and Thurishtia were gone… but we were still apparently in the netherzone. I was happy to be alive… but I was afraid that we were now trapped where Simultaneous had been!
"Like, whoa… she was like really bummed to see old Simmy among the living! And I'venever seen him throw his weight around like that before! Like.. wow!" Renet was saying as I was busy walking around looking for some clue as to what had happened… but all was blackness.
"Like… uh oh…" Renet murmured… and I turned to see Thurishtia standing before us. She looked as darkly radiant as ever. "My son has requested a happy ending, and so I am compelled to grant his final wish of me…" with that she snapped her fingers and I was back with Renet in Lord Simultaneous' keep. Simultaneous was nowhere to be found, but his most powerful magical artifact was… the Digital Cosmic Quartz… an item infinitely more powerful than the Time Sceptre! There was a note attached to it that read "Renet: I have done my best to teach you the discipline you need to be an effective governor. The time has arrived for you to assume your role. Use the Quartz well and as I have taught you. Thurishtia will trouble you no more, but I can longer serve my former role, as the sands have shifted and I now have other duties. Protect that which needs protecting. Be wary and be careful and for goodness sake be wise for a change!" it was signed by Lord Simultaneous.
"Like… WOW!" was all Renet said for about 45 minutes.
Eventually Renet came to understand what had happened and what her new "job" was. It was a difficult transition for her to make, and I stayed with her for several weeks to help her adjust. She was all alone now in a vast megaverse… heiress to a throne that she never assumed she would ascend. But she is a good person, and she will do a fine job. I'm no magician and I can't see into the future, but I am a good judge of character.
Once Renet had settled into the concept of being a time lord herself, she began to set things right that Thurishtia had disrupted earlier. She met no resistance. Her final act before taking me home was to seek out Savanti Romero… to find out if he had survived, if nothing else. It was a long search, we spent over a week just doing this, but we found him. Thurishtia had sent him to a far removed planet in an ancient time. She had removed any magical abilities he had left when she destroyed the Time Sceptre… and he had been captured and imprisoned by a primitive people. They had not been kind to him. He was in worse shape than ever once we found him… his body was battered and bruised and his spirit was broken. Renet took him back to her Keep and restored him to his former body (Simultaneous had mutated him into a demon-like being as a form of punishment). I pitied Savanti then, as he lie in bed in his human-looking form. He was an utterly defeated old man, haunted by the horrors of imprisonment and despondent over his lost abilities. He seemed to be dying, and Renet saw to it that he was as comfortable as possible. I cautioned her that he might betray her goodwill, but she insisted on helping him. She was sure that his efforts to free Simultaneous had allowed the Lord to save us all in the end. Perhaps she's right… perhaps Savanti's final act as a free being had been one of goodwill. I'd like to think so anyway.
We buried him a week later in a flower garden Renet had planted at the base of the castle. She had made many changes to the keep and its grounds since Simultaneous' departure. "Simmy's tastes were grim, monochromatic and yucky!" she exclaimed to me after I asked her about the goldfish she had placed in the moat "If I'm going to be a guardian of goodness throughout time and space, I at least want my house to look happy!" I didn't say anything when she painted the drawbridge pink.
She took me home shortly thereafter. All of my family was back, and while we were all a little worse for wear, we were very excited to be together once again. Our time in this world is far too short. It's a real blessing to have good friends and family to share our brief moments with. I count my blessings everyday and am thankful that I've been given so many.
Thanks for reading this. I hope you've been well, my friend.
Previous Article← 1998-09 – Letters from Venus


Today, November 11, 2018, is the 100th anniversary of Veterans Day. Originally known as Armistice Day, it was set to honor the end of World War I, which happened on the 11th hour of the 11th day of the 11th month of 1918. It became a legal holiday in the U.S. in 1938 and was renamed as Veterans Day in 1954.
It is our opportunity to thank and celebrate all those who have served our country in military service. Thank you for your service!
Below is a beautiful five-minute video put together last month by a high school student.
Wow! This is the most meaningful thing I've seen on the topic and I want to share it. Do you know who the student who made it is?
Please also hold in your heart the mercenaries and contractors who went where governments couldn't, to do the things that governments wouldn't. These were my friends, colleagues, and brothers, and the faces of the lost beckon me to Heaven.
very powerful. and thank you, Andrew, we forget, and our thanks go to all who served, and those who served and had no recognition. And to those who gave all.
My entire family get phone calls and a lot of love and respect, and our parents / in-laws, too.
The young high school student who put together this beautiful remembrance and tribute to our service members is to be highly commended! With tears in my eyes and a sodden Kleenex in hand, the memories of the wars during my life time came flooding back. My husband was a WW ll Army Air Corps fighter pilot, and as he soars the wild blue yonder I know he would have been so proud of the young person who shared this on a special day. My thanks.
What a beautiful tribute to those who served.
It's personal. My husband served two years in the navy, though thank God, it was not in war time. Thank you, Frank. You are my hero.
Beautiful presentation. I'm so thankful our nation and people have returned to honoring our military. I remember the climate in the 70s when there was plenty of disdain for veterans and active military.
Thank you! My husband served in the U.S. Navy.
On behalf of Arnie, thank you, Steve. And thanks to all of you veterans for your service and sacrifices.
Many thanks for a powerful tribute to those brave ones who made it possible for us to live free. We have two sons in the military; one did a tour of duty in Iraq.
Outstanding! As the mother of a 100% disabled Army vet and the daughter of a World War 2 veteran, this type of tribute warms my heart.
So deeply moving. Thank you for sharing this, Steve.
Thank you.For my grandfather, a WW1 veteran, my Father-in-law a wounded WW11veteran and my son, an Army Reservist. And the countless others so deserving of our gratitude.


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Joanne E. Mortimer, MD, FACP | Authors
Lessons Learned From the Use of ESAs
Dr. Bennett and colleagues have provided a thorough and balanced history of the rise and fall of erythropoietin-stimulating agents (ESAs) in cancer-associated anemia. Their review encourages us to think about the lessons learned from this history-lessons about medical progress, the importance of clinical research in guiding clinical practice, and the role of the US Food and Drug Administration (FDA) in protecting patients
Commentary (Mortimer): Managing Early-Stage Breast Cancer in Your Older Patients
As the aging population in the United States continues to grow, the incidence of diseases of the elderly, such as breast cancer, are increasing. Many more elderly women are expected to be diagnosed with new breast cancers, most of them in an early stage. Appropriate treatment of these women is important, as they have poorer outcomes when undertreated. In this review, we will discuss the biology and treatment of early breast cancer in elderly women. We will focus on the role of comorbidity and its effect on life expectancy, treatment decisions, current recommendations for primary treatment with surgery, radiation and neoadjuvant strategies, and adjuvant treatment including local radiation therapy and systemic treatment with endocrine therapy, chemotherapy, and newer agents. Finally we will discuss the importance of clinical trials in the elderly.
Long-Term Toxicities of Selective Estrogen-Receptor Modulators and Antiaromatase Agents
Published literature indicates that the selective estrogen-receptormodulators (SERMs) tamoxifen and raloxifene (Evista) have favorableeffects on bone density, lipid profiles, and the incidence of secondbreast cancers, and unfavorable effects on the incidence of venousthrombosis and hot flushes. Tamoxifen increases the risk of endometrialcancer, but raloxifene does not. The effects of SERMs on sexualfunction and cognition are unclear. Because the selective antiaromataseagents are relatively new, the long-term effects of these agentson normal tissues are less well established. It appears that the nonsteroidalagents (anastrozole [Arimidex], letrozole [Femara]) and steroidal(exemestane [Aromasin]) antiaromatase agents may have differenteffects on normal tissues. Preliminary data demonstrate that anastrozoleincreases the risk of arthralgias and produces a decrease in bonedensity. In contrast, exemestane appears to favorably affect bonedensity and lipid profile, similar to tamoxifen and raloxifene. Theincidence of contralateral breast cancer is decreased in women onadjuvant anastrozole, but data for the other antiaromatase agents arenot yet available. Hot flushes have been reported with the use ofselective aromatase inhibitors, but their incidence seems to be comparableto what is reported with SERMs. Antiaromatase agents do notappear to cause venous thrombosis. More information about the effectsof the antiaromatase agents on normal tissue will become available asdata from ongoing adjuvant and chemoprevention trials are reported.Clinically, we should be conscious of the differences between antiaromataseagents and SERMs and their impact on women's health.

redpajama_set_name: RedPajamaCommonCrawl


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Padres Recap: Norris at 1st, Alonso at 3rd, and Padres Win
By Andrew Beccarelli
Pat Murphy got his first win as manager of the San Diego Padres with today's 3-1 victory over the Oakland A's. How did he celebrate, well he was grabbed by some players, carried into the shower and doused with a combination of beer, champagne and baby powder (via ESPN).
While I'm sure the players were excited to get a win for their new skipper maybe they were more excited to break their five game losing streak? Whatever the reason, just win more games guys.
Ian Kennedy got the start and threw six innings giving up four hits and one run (a homer). Shawn Kelly and Brandon Maurer threw scoreless innings each. Craig Kimbrel got the save, his 17th of the year.
The other big news out of today's game was the starting lineup:
#IPK on the mound for the final game of the series with the Athletics. Here's how the #Padres will lineup today: pic.twitter.com/oLuxf3TiU3
— San Diego Padres (@Padres) June 18, 2015
Yehp, that's Derek Norris starting at firstbase and Yonder Alonso at thirdbase. We've heard the Padres had been experimenting with this in their pregame warmups, but today we finally got to see it in action. I know it's just a one game sample size but I hope to see this alignment more in the future.
Matt Kemp (2-4) got the offense going today with a solo homerun in the fourth. Norris (1-4) followed up with a homer of his own in the sixth. Finally, Melvin Upton (1-4) tripled in the eighth, then scored on a Justin Upton (0-2) sacrifice fly.
The Padres are their way to Phoenix now for a series with the Arizona Diamondbacks, James Shields will start for the Pads on Friday.


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Q: julia installation FUBAR I am trying to install a fresh julia on a linux box, and get this. Any suggestions about what to do, and what is causing this?
(@v1.7) pkg> add LLVM
   Resolving package versions...
ERROR: Unsatisfiable requirements detected for package LLVM [929cbde3]:
 LLVM [929cbde3] log:
 ├─possible versions are: 0.9.0-4.9.1 or uninstalled
 ├─restricted to versions 3.9.0 by an explicit requirement, leaving only versions
3.9.0
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Inspired by my lovely new unique next to Chai Bud.
I love the new spacer too.
Wonderful! I love seeing all those Oldi - Greens!!
Great design! I love the color, very calming indeed!
Beautiful...I love the mix of old and new. Great way to still use older beads and refresh with a touch of new.
Oh wow, what a great combo of muted greens! Love it!
I am normally not a fan of green, but this is gorgeous!


I am writing in support of the Greek proposal to address some of the most visible and pressing issues at Dartmouth today. I believe the students involved in the Greek societies are committed to reform. This creates a wonderful opportunity for the Administration to work with the students. Improving a system that is loved by current students and alums is the right answer. Abolishing the societies or mandating reform that the Administration wants, but is not supported by the students involved in the Greek system, is a great way to satisfy the vocal opposition, but will disenfranchise a significant portion of the current student body (and alums). I very much hope that you give these students a chance at reform.


2/3/14, i enjoyed your presentation this evening at the VAC in newport this eveing. it is fun to watch someone so passionate about what happens to a drop of water as it falls into a cup. StevePower / fellow photographer.
have you tried processing your images with hdr software? it can produce subtle textures in the final image.
Noted you have not posted since 2010.
Are you off to other pursuits or work not allowing entries?
I enjoy your photography and am now full time in landscape photography sales in Tucson, Az.
I am a fine art photographer with a question I think you can only answer.
I want to create a collection of images similar to yours for an exhibition. I was looking at splash art but also the MJKZZ as recommended by Corrie White.I am a beginner in this field but need a collection by 2 months time.I am working with Leica m9 and dont want to change.As you probably know the leica doesnt have a wired shutter release port or hot shoe to pc adapter either for this camera. I have been advised to use on bulb mode but how will this work with the MJKZZ? Also the leica 120mm lens is not macro as they dont make macro lenses, is this a big problem? I dont fancy buying canon gear.I want to get this right from the start not to be upgrading kits all the time or changing.Could you please suggest a set up for my Leica m9 and lenses.
what inspired you to do liquid based pictures as i am fascinated in the technique used and i have been inspired by you to create these photos in the future.


Ponlawat Buansiri was born in Bangkok, Thailand. Within a few years of graduating from Chulalongkorn University in 1991, Ponlawat won the Asahi Glass House, Gypsum Board House and Spontaneous Healing House competitions and his "Linkage" design was selected by Tadao Ando and Jeffrey Kipnis as the first prize winner of the ASA Experimental Architecture competition.
Songsuda Athibai was also born in Bangkok, Thailand, and graduated with a B.Arch from King Mongkut Institute of Technology Ladkrabang in 1995 and a masters degree in Landscape Architecture from the University of Colorado at Denver in 2000. Though she alone earned the New Spirit of Thai Architecture award from the Association of Siamese Architects, she was unable to find any support in Thailand for her visionary designs until her first collaborations with Ponlawat.
In 2005, after being selected as one of the 20 finalists for The Grand Egyptian Museum competition in 2002 and one of 5 finalists for the Irish World Performing Arts competition in 2004, Ponlawat and Songsuda established S+PBA.
Taylor Lowe joined S+PBA in 2008. He graduated with highest honors in both Economics and Literature from UCSD, and earned his M.Arch from The School of the Art Institute of Chicago (SAIC). His critical writings have garnered both the Berkhardt Prize and the Schiff Prize. Drawing on his background in literature and theory, Taylor assists Ponlawat and Songsuda in first 'reading' the stories, subtexts, contexts, textures and implications behind each project and then manifesting them in the embodied experiences of S+PBA's architectural statements.
Ever since their childhoods, both Ponlawat and Songsuda have shared an inexhaustible love and fascination for architecture. Songsuda's independent spirit and fertile imagination find a harmonic balance with Ponlawat's keen vision, extraordinary spatial and material intuition, and architectural wisdom borne of extensive experience. Together, working in the capital of a third world country, against conservative notions of what constitutes 'Thai Architecture,' they strive always to make the most with less. S+PBA aspires to find the hidden potential in the mundane and undervalued, and convert simple processes and conditions into extraordinary architecture that competes at an international level with even the most resource intensive of contemporary design.
Ponlawat and Songsuda are both faculty at the School of Architecture and Design (SoA+D) at KMUTT. Taylor is faculty at the International Program for Design and Architecture (INDA) at Chulalongkorn Univerity.


Battelle Ventures, L.P., and its affiliate fund, Innovation Valley Partners (IVP), have a combined $255 million under management to create and accelerate the development of early-stage technology companies with breakthrough solutions to key market problems.
The funds enjoy close relationships with the technology transfer offices of the National Laboratories that Battelle Memorial Institute (Battelle) manages or co-manages for the U.S. Department of Energy. They also have established similar associations with a number of university tech transfer and commercialization departments.
Battelle is the $220-million, Princeton, N.J.-based Battelle Ventures fund's sole limited partner and Eastern Tennessee business leaders back the $35-million, Knoxville, Tenn.-based IVP fund. Battelle Ventures' general partners also are general partners of IVP.
Planar Energy is a privately held, venture capital-backed technology company.


text:
2023 Mercedes-AMG EQS Review, Pricing, and Specs
BySiddharth Singh
Just because the 2023 Mercedes EQS is electric doesn't mean it can't be an AMG. The brand's performance division has taken to the flagship electric sedan and added lots more power and performance. Upgraded electric motors offer 649 horsepower. This figure rises to 751 hp with the optional boost mode engaged. Other modifications include a firmer suspension and additional driving modes, although there are no changes to the 107.8-kWh battery pack. Driving range takes a hit due to the less aerodynamic bodywork. It's expensive, but if power and exclusivity are your things, this big, fast, and quiet four-door could be for you.
A new exterior paint color, called Twilight Blue Metallic, is the only change for 2023.
Pricing and Which One to Buy
As you'd expect, Mercedes slaps the AMG EQS with a significant upcharge compared with the non-AMG EQS. With a six-figure starting price, this high-performance EV isn't cheap, and a long list of personalization options can drive the cost even higher. But with this much performance and a price tag this high, the AMG EQS will be on track to take on other speedy EV luxury sedans such as the Audi e-tron GT, the Porsche Taycan, and the high-performance Tesla Model S Plaid.
Engine, Transmission, and Performance
The AMG EQS has a similar setup as the standard EQS, with one electric motor on the front axle and a second motor on the rear axle, providing all-wheel drive. But there's plenty of extra power on tap, with the standard AMG EQS providing 649 hp—significantly more than the EQS580's 516 hp—and 700 pound-feet of torque. Opting for an AMG Dynamic Plus package pushes those numbers even higher, with a boost function able to provide 751 horsepower and 752 pound-feet. We thought the AMG version felt quicker than the standard EQS during our drive, and we were right. The AMG-badged EQS hit 60 mph in 3.0 seconds flat at our test track, 0.7 seconds ahead of the Benz-branded EQS580. In corners, the big and heavy EQS is stable and planted, with better body control than the non-AMG model. But despite AMG's suspension tweaks and the rear-axle steering, it's not as agile as other EV sedans such as the Taycan. Fortunately, the AMG model maintains the smooth ride of the standard EQS.
More on the Mercedes-AMG EQS Sedan
Range, Charging, and Battery Life
The AMG EQS has the same 107.8-kWh battery pack as the non-AMG model, but its more powerful electric motors decrease efficiency slightly. The AMG-tuned EQS's EPA-rated range comes in at just 277 miles per charge versus the EQS580's 340 mile estimate. In our testing though, we observed an impressive 290 miles of driving range on the highway for the AMG, indicating that it's possible to outperform the EPA's estimate. The EQS580, it should be said, also outperformed its rating in this same test and delivered 350 miles of range. Mercedes makes similar charging claims for the AMG EQS as the base model, as it has fast-charging capability. For the first two years, Mercedes will provide free fast-charging access through Electrify America, but the individual sessions will be limited to 30 minutes.
Fuel Economy and Real-World MPGe
The EPA estimates that the Mercedes-AMG EQS is good for 76 MPGe city and 78 MPGe highway. Those figures are much lower than the regular Benz-branded model but are on par with other performance-oriented electric sedans such as the e-tron GT and the Taycan. For more information about the EQS's fuel economy, visit the EPA's website.
Interior, Comfort, and Cargo
Mercedes has made it clear that its electric vehicles will feature the same sumptuousness as its gasoline-powered luxury cars, and the AMG EQS is no exception. It offers the same giant Hyperscreen setup, with a massive screen stretching across the entire dashboard. The main differences are the additional performance driving modes and displays for the AMG; Mercedes also offers a wider range of trim options, including carbon fiber and aluminum. The AMG model also features fake sounds piped into the cabin that attempt to add some auditory excitement to the otherwise quiet acceleration; we found them to be silly, but some might enjoy the robotic noises.
The Car and Driver Difference
Infotainment and Connectivity
The EQS's massive Hyperscreen is unlike any other infotainment system we've seen. It uses Mercedes's MBUX software and allows for a lot of customizable display options. There's also an available head-up display with an augmented reality function. The Hyperscreen also supports the Apple CarPlay and Android Auto smartphone-mirroring functions.
How to Buy and Maintain a Car
Safety and Driver-Assistance Features
The AMG EQS will have a driver-assistance package as standard, meaning it comes equipped with features such as adaptive cruise control, automatic emergency braking, and lane-keep assist. For more information about the EQS's crash-test results, visit the National Highway Traffic Safety Administration (NHTSA) and Insurance Institute for Highway Safety (IIHS) websites. Key safety features include:
Standard automated emergency braking with pedestrian detection
Standard lane-departure warning and lane-keeping assist
Available adaptive cruise control with semi-autonomous driving mode
Warranty and Maintenance Coverage
While Mercedes has yet to release detailed warranty information on the AMG EQS, we expect it to feature similar coverage as the non-AMG EQS, listed below.
Limited warranty covers four years or 50,000 miles
Powertrain warranty covers four years or 50,000 miles
Electrical components are covered for 10 years or 155,000 miles
Complimentary scheduled maintenance is covered for two years
2022 Mercedes-AMG EQS 4Matic+
Vehicle Type: front- and mid-motor, all-wheel-drive, 5-passenger, 4-door hatchback
Base/As Tested: $148,495/$159,055
Options: front carbon-ceramic brakes, $5450; 22-inch wheels, $1850; laminated glass, $1010; four-zone climate control, $750; HEPA filtration for climate control, $450; cabin fragrance, $350; AMG Track Pace app, $250; 110-volt charging cable, $250; dashcam, $200
Front Motor: permanent-magnet synchronous AC
Rear Motor: permanent-magnet synchronous AC
Combined Power: 751 hp
Combined Torque: 752 lb-ft
Battery Pack: liquid-cooled lithium-ion, 107.8 kWh
Onboard Charger: 9.6 kW
Transmissions, F/R: direct-drives
Suspension, F/R: multilink/multilink
Brakes, F/R: 17.3-in vented, cross-drilled, carbon-ceramic disc/14.9-in vented disc
Tires: Michelin Pilot Sport EV
275/35R-22 104Y MO1
Wheelbase: 126.4 in
Cargo Volume: 22 ft3
Curb Weight: 5911 lb
C/D TEST RESULTS
60 mph: 3.0 sec
100 mph: 7.6 sec
1/4-Mile: 11.4 sec @ 119 mph
130 mph: 14.5 sec
Results above omit 1-ft rollout of 0.2 sec.
Rolling Start, 5–60 mph: 3.3 sec
Top Gear, 30–50 mph: 1.3 sec
Top Speed (gov ltd): 154 mph
Braking, 70–0 mph: 167 ft
Braking, 100–0 mph: 333 ft
Roadholding, 300-ft Skidpad: 0.92 g
C/D FUEL ECONOMY
75-mph Highway Range: 290 mi
2023 Mitsubishi Outlander Sport Review, Pricing, and Specs
Auto Expo 2023 Live Updates: Launches, Showcases, & More
By Siddharth Singh


sometime the pretty fall down.
and then more fall and i can't stop it.
i just watch it fall and watch the wind pull the petals apart.
I love this photo, love this post, and I am putting in an order for blue skies to come to all of us, soon.


text:
JOIN OUR VIP COMMUNITY
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Tim Hayes
Tim is an internationally acclaimed personal trainer and the Founder of Peach. In addition to his BSc Hons degree he holds a Diploma in Sports Science and is a qualified Nutrition coach, and has specialist credentials in Pre and Postnatal Exercise, Corrective Exercise, Programme Design, Core Conditioning and functional biomechanics, the science that sits behind how to move. Tim has worked all over the world with clients from all walks of life from stay-at-home mums, too busy executives, A-list celebrities and top international models.
Tim specialises in: Body weight, Cardiovascular, Weight loss, Conditioning, Biomechanics, Pre/Post natal, Coaching, Rugby, Tennis, Rehabilitation
Founder of Peach
South London Trainers
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For those looking to return to fitness, get back in the saddle with Amram. This former professional cyclist and running coach promises a functional, technique based workout. With 8 years experience training tennis, golf and running athletes, Amram can also take your swing or stride up a gear. Sufferers of long term conditions ranging from back issues to fibromyalgia will also find a patient and skilled trainer in this Catalan coach.
With 8 years experience training tennis, golf and running athletes, Amram can take your swing or stride up a gear. Sufferers of long term medical conditions will also find a skilled trainer in this Catalan coach.
Contact Amram
India is a knowledgeable and experienced personal trainer, with six years in the industry under her belt on top of a degree in sports science. She's passionate about women's fitness and nutrition in particular, with her specialist knowledge in gut and hormone health helping her clients to feel better in themselves whilst reaching their goals. India's scientific studies into functional and resistance training have seen her entrusted by leading sportsmen and celebrities, whilst her favourite sports to train are horse riding and polo.
India is an experienced personal trainer with six years in the industry under her belt on top of a degree in sports science. She's passionate about women's fitness and nutrition, with specialist knowledge in gut and hormone health.
Contact India
Adam J
Adam, former ruby professional (England Rugby Union, England Rugby League academy, London Wasps and Broncos Rugby League), is an enthusiastic, engaging and motivating fitness professional with a fun, friendly and caring nature.
He studied at St Mary's University and graduated with a Sports Science and Strength Conditioning degree. During which he worked as an academy and second team strength and conditioning coach for Harlequins Rugby League.
The greatest satisfaction for him is enhancing the health and wellbeing of his clients and empowering them to evolve into a better version of themselves.
Adam is former ruby professional (including England Rugby Union) with a Sports Science and Strength Conditioning degree from St Mary's university where he worked as a strength and conditioning coach for Harlequins Rugby League.
Anna is driven by real results with a fad-free focus. Her sporting-background gives Anna a true competitive edge. Choose her to make your goals, her goal. Anna builds close, trusting relationships with her clients and trust us, you want her on your team. She says: "I love feeling strong and I want you to feel the same way." Expect strength building workouts which incorporate yoga and flexibility brought to you at home, in the workplace or the outdoors. Let's take this outside.
Anna is driven by real results with a fad-free focus. Expect strength building workouts which incorporate yoga and flexibility brought to you at home, in the workplace or the outdoors.
Contact Anna
Francesca S
Mum's the word! Francesca brings a unique pre and post natal fitness specialism to Peach. She can help Mums maintain or regain their bodies, with an absolute focus on working out safely and steadily. With over 11 years experience in offering diverse, client-specific workouts to new and expectant mothers, you can be sure you're in expert hands.
Francesca brings a unique pre and post natal fitness specialism to Peach. She can help Mums maintain or regain their bodies, with an absolute focus on working out safely and steadily.
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Following an international footballing career with the Ugandan national youth squad and in the Kenyan Premier League, Joel made a career in the top flight of fitness his next goal. He's been training clients in the UK for five years, specialising in conditioning and high intensity weight lifting. Joel likes to push himself to the edge, and you can guarantee he'll push you too. If you want to build muscle, speed or just get back to giving your kids the runaround in the garden, Joel is your star player. "It's not about me or you, it's about us." We want to be on Joel's team.
Following an international footballing career in the Kenyan Premier League, Joel has been training clients in the UK for five years, specialising in conditioning and high intensity weight lifting.
Contact Joel
With 15 years of experience behind her, Juli is one of our most experienced Peach trainers; she is passionate about helping people find themselves - 'their purpose and vision in life' - through mindful lifestyle training and evidence based coaching. A former European Bikini Championships competitor, Juli is not only an internationally certified fitness practitioner, she is also qualified in nutrition, psychology and life coaching, pure form pilates and yoga. With a clear understanding of the overwhelming pressures of today's society, Juli finds happiness on a daily basis through positively influencing her clients' mental and emotional feelings about their body, all whilst helping them achieve their specific fitness-based goals.
A former European Bikini Championships competitor with 15 years experience, Juli is not only an internationally certified fitness practitioner she is also qualified in nutrition, psychology, life coaching, pure form pilates and yoga.
Contact Juli
Henrique practices movement as a therapy to help you overcome a pain or performance hurdle. He works with top executives coming out of complicated injuries or surgery that want to get back to their full abilities. They end up training with him for the long run as they realise the impact it has on their performance, resilience and longevity.
Henrique practices movement as a therapy to help you overcome a pain or performance hurdle. He works with top executives coming out of complicated injuries or surgery that want to get back to their full abilities.
Contact Henrique
Times have changed, and so should training. James is one pioneering PT leading the evolution in exercise and injury rehabilitation. We guarantee you won't find his movements in a fitness magazine or on the internet. This workout promises to be bespoke and tailored to fit your fitness. Choose James for a workout routine that's far from a routine workout.
James is one pioneering PT leading the evolution in exercise and injury rehabilitation. We guarantee you won't find his movements in a fitness magazine or on the internet. This workout promises to be bespoke and tailored to fit you.
Contact James
Movement specialist Jem will take you from from fragile to agile, by improving your range of motion and mobility. His clients include seasoned athletes looking to regain flexibility and complete beginners taking tentative first steps into the gym. Expect diverse workouts that pack a hit with boxing and mixed martial arts integrated into your training. Nothing knocks out stress like a round on the punch pads.
Movement specialist Jem focuses on improving your range of motion and mobility. His clients include seasoned athletes and complete beginners. Expect diverse workouts that pack a hit with boxing and mixed martial arts integrated into your training.
Contact Jem
A keen athlete from an early age, Stephen began his personal training journey 13 years ago, completing a degree and multiple PT qualifications. He has always enjoyed the physical and mental rewards that follow a great training session, and is passionate about passing this joy and knowledge onto others. And well as individuals, Stephen has trained sports teams and has worked at multiple well known fitness chains in the past - even having the opportunity to work alongside two time Olympic decathlon champion Daley Thompson. His growing reputation in the industry allowed him to open his own studio in prime West London; he's now an established figure in the local fitness scene, and is involved in a number of projects to 'heal the world'.
Stephen's 13 years of experience has seen him training sports teams and working at multiple fitness chains, including alongside Olympic decathlon champion Daley Thompson, all of which has lead to him opening his own studio in West London.
Feeling burnt out? Francesca B could be the trainer to help you undergo a complete lifestyle overhaul. With over 18 years of experience and a multitude of qualifications under her belt, Francesca's trademark multidisciplinary approach combines her in depth knowledge of physiology, postural alignments, the nervous system, breath work, nutrition and psychology for a 360 approach to wellness. A favorite of stressed out execs, entrepreneurs, and public personalities. Francesca will not only help you to get fitter, but also help you feel more grounded and resilient overall.
Francesca's trademark multidisciplinary approach, backed by 18y of experience, combines her in depth knowledge of physiology, postural alignments, the nervous system, breath work, nutrition and psychology for a 360 approach to wellness.
Contact Fran B
Simon's journey to fitness professional started as a badminton player, leading to a career as a coach. That coaching background makes Simon the perfect mentor for those aiming to level up, whatever your sporting field. Functionality is at the core of Simon's training style. So if you're not an athlete, but just looking to increase flexibility and form, get on the Green team.
Simon understands the importance of the Peach ethos of selecting the PT with the qualified expertise you need. "Anyone can show you exercises. Not everyone can tailor exercises to suit your individual needs."
Simon's journey to fitness professional started as a badminton player, leading to a career as a coach. That coaching background makes Simon the perfect mentor for those aiming to level up, whatever your sporting field
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Whether you see exercise as a treat, a chore or a challenge you will look forward to your training sessions with Mounir. With experience and qualifications in injury rehabilitation, strength training, boxing, 3D movement and calisthenics, Mounir goes out of his way to make training enjoyable for each and every client he's coached over his decade of practice. A self confessed challenge obsessive, he excels at helping to ready his clients for specific events - whether it's your first 5k or a national triathlon, Mounir will get you over the line injury free and feeling your best.
With experience and qualifications in injury rehabilitation, strength training, boxing, 3D movement and calisthenics, Mounir goes out of his way to make training enjoyable for each and every client he's coached over his decade of practice.
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Lee T
Searching for a six-pack? Lee can help you find it. With a background in building and bulking rugby professionals Lee will help you make that muscle. But it's not all about the biceps – Lee also brings expertise is eviscerating fat and cardio conditioning. Remember, strong is the new skinny. So pick your targeted goal and let's get you there. Your body won't just be a temple, it will be a fortress.
With a background in building and bulking rugby professionals Lee will help you make that muscle. But it's not all about the biceps – Lee also brings expertise is eviscerating fat and cardio conditioning. Remember, strong is the new skinny.
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What is a Wonderwall, anyway?
Oasis' belting one-liner "You're gonna be the one that saves me" has been voted as one of the most common misheard lyrics of all time. The Police top the chart for When The World Is Running Down with Bee Gees' Stayin' Alive and The Beatles' Lucy In The Sky With Diamonds at second and third respectively.
The survey, carried out by hearing aid retailer Amplifon, discovered that deaf or hard of hearing Wonderwall listeners actually hear "You're gonna be the one at Sainsbury's".
We've touched on this subject before, citing Bruce Springsteen and Led Zeppelin among our top listening errors. And, although the 'hard of hearing' are no laughing matter, would anyone mind if Kate Bush actually did wail "Heathcliff, It's me, I'm a tree, I'm a wombat"?
Lyric: "You make the best of what's still around"
Misheard as: "You make the best homemade stew around"
Lyric: "It's alright, it's okay. You may look the other way"
Misheard as: "It's alright, it's okay. You make love the other way"
Lyric: "The girl with kaleidoscope eyes"
Misheard as: "The girl with colitis goes by"
Lyric: "She moves in mysterious ways"
Misheard as: "Shamu the mysterious whale"
Lyric: "Michelle ma belle, sont les mots qui vont tres bien ensemble, tres bien ensemble"
Misheard as: "Michelle ma belle, some say monkeys play piano well, play piano well"
Lyric: "Scaramouche, Scaramouche, will you do the Fandango"
Misheard as: "Scallaboosh, Scallaboosh, will you do the banned tango"
Lyric: "A year has passed since I wrote my note"
Misheard as: "A year has passed since I broke my nose"
Lyric: "Strange fascination fascinating me"
Misheard as: "Strange vaccinations are killing me"
Lyric: "You're gonna be the one that saves me"
Misheard as: "You're gonna be the one at Sainsbury's"
Lyric: "Heathcliff, It's me, Cathy and I've come home oh, so cold, let me in-a your window"
Misheard as: "Heathcliff, It's me, I'm a tree, I'm a wombat. Oh, so cold at the end of your winter"


text:
"Everybody Ought to Treat a Stranger Right" is a gospel blues song recorded in 1930 by Blind Willie Johnson with backing vocals by Willie B. Harris, who may have been his first wife. The song was released in 1930 on Columbia 14597 as B-side to "Go with Me to That Land".

The chorus consists of the lines:

The verses comment on that idea, notably with reference to the Three Wise Men offering gifts to the Christ-child in the manger.

In 2018, Ry Cooder recorded the song for his album The Prodigal Son. He commented that it was "one of Blind Willie Johnson's great songshe's the go to guy".

References

Blues songs
Gospel songs
Blind Willie Johnson songs
1930 songs
Songwriter unknown

redpajama_set_name: RedPajamaWikipedia


The Details for 1114 8th Ave.
Assigned Schools for 1114 8th Ave.
1114 8th Ave. Belvidere, Illinois 61008 is a single family property, which sold for $135,405. 1114 8th Ave. has 3 bedroom(s) and 2 bath(s). Want to learn more about 1114 8th Ave. Belvidere, Illinois 61008? Contact an @properties agent to request more info.


text:
Q: Creating a Stream from a List to Build Cards
I'm creating a Home Auto Application. I have several button datas stored inside my Database (Realtime Database). In my home page I created a StreamBuilder to listen to whenever there is a button created or any type of data that has entered or leaved.
I'm currently having problems with my StreamBuilder, I can't access the data from it on the main page, and when I try to print the snapshot.data, I get 0 as response. The Stream is a List.
This is the output from snapshot.value:
[{icon: delte, nome: Junior}, {icon: add, nome: Televisao}, {icon: bulb, nome: BAtata}]

This is the Stream:
Stream<List> readData() async*{
    Map<dynamic, dynamic> button_list = Map();
    var lst = [];

    final FirebaseUser user = await _auth.currentUser();

    Stream stream = await databaseReference.child(user.uid+"/buttons/").once().then((DataSnapshot snapshot) {
      final value = snapshot.value as Map;
      lst = value.values.toList();

    });

    await for(var event in stream) {
      yield event.lst;
    }
  }

I will be using the content from the list to create the buttons.
This is the create card page:
import 'package:flutter/material.dart';

class CreateCard extends StatelessWidget {

  String name;
  String icon;
  CreateCard(this.name, [this.icon]); //[] para que o icon não seja obrigatorio de colocar

  @override
  Widget build(BuildContext context) {
    return GestureDetector(
      onTap: (){

      },
      child: Container(
        width: 150,
        height: 150,
        decoration: BoxDecoration(
          color: Colors.black,
          borderRadius: BorderRadius.circular(15)
        ),
        child: Stack(
          children: [
            Positioned(
              top: 10,
              left: 10,
              child: Icon(
                icon == null ? Icons.check_box_outline_blank : getIconData(icon),
                size: 35,
                color: Colors.white,
              ),
            ),
            Positioned(
              top: 95,
              left: 15,
              child: Text(name, style: TextStyle(color: Colors.white),),
            ),
          ],
        ),
      ),
    );
  }
}

IconData getIconData(String name) {
  switch (name) {
    case "Lock":
      return Icons.lock;
    case "LightBulb":
      return Icons.lightbulb_outline;
    case "Check":
      return Icons.check;
  }
}

This is the Home Screen:
import 'package:automacaoaplicativo/buttons/create_card.dart';
import 'package:flutter/material.dart';
import 'package:automacaoaplicativo/services/auth.dart';

class Home extends StatefulWidget {
  @override
  _HomeState createState() => _HomeState();
}

class _HomeState extends State<Home> {

  final AuthService _auth = AuthService();

  @override
  Widget build(BuildContext context) {
    return Scaffold(
      backgroundColor: Colors.grey,
      appBar: AppBar(
        title: Text('Main page'),
        actions: <Widget>[
          FlatButton.icon(onPressed: () {
            _auth.signOut();
          },
          icon: Icon(Icons.logout),
          label: Text('Logout'))
        ],
      ),
      body: StreamBuilder(
        stream: _auth.readData(),
        initialData: 0,
        builder: (context, snapshot) {
          if (snapshot.hasError || snapshot.hasError){
            return Container(color: Colors.red);
          }
          if (!snapshot.hasData || !snapshot.hasData){
            return Center(child: CircularProgressIndicator());
          }
          if (snapshot.hasData || snapshot.hasData){
            return GridView.count(
              padding: EdgeInsets.all(15),
              crossAxisSpacing: 20.0,
              mainAxisSpacing: 20.0,
              crossAxisCount: 3,
              children: [
                CreateCard("ola"), // I would need to loop throw this card and
send the data from readData() on the list format,
 CreateCard(snapshot.data[0][0], snapshot.data[0][1]) and so on for position 1, 2, etc
                GestureDetector(
                  onTap: () async{
                    _auth.readData();
                  },
                    child: Container(
                    color: Colors.black,
                    width: 150,
                    height: 150,
                    child: Icon(Icons.add, color: Colors.white,),

                  ),
                ),
              ],
            );
          }
        }
      ),
    );
  }
}

This is how the app is looking, there was supposed to be 3 of these black boxes since I have 3 data from buttons, If I had 4 there was supposed to be 4, and so on:
App

A: You should try matching your stream design pattern to something like this:
void main() async {
  // This is where you would use a StreamBuilder rather than this use.
  await for (var value in getData()) {
    print(value);
  }

  /*
   * return StreamBuilder<List>(
   *  stream: getData(),
   *  builder: (context, snapshot) => YourWidget(snapshot.data);
   * );
   * */
}

// This is *your* Stream function.
Stream<List> getData() async* {
  var list = [];

  // Make sure the stream you are wrapping is invokable.
  await for (var data in mockRemoteData(10)) {
    // this is where you do you data manipulation.

    list.add(data);
    yield list;
  }
}

// Ignore the implmentation, just imagine you are recieving data from a network
// and it just timeouts at some point.
Stream<int> mockRemoteData(int timeout) async* {
  int i = 0;
  while (true) {
    await Future.delayed(const Duration(seconds: 1));
    yield i++;
    if (i == timeout) break;
  }
}

getData() is the function you are trying to make. You are basically wrapping another Stream, in the example it is mockRemoteData(). Try matching your code to this pattern.


Reccolab: L' Aperitivo Italiano Sunset Sessions all Summer!
Inner west Sunday sessions are in full swing after the launch last weekend of ReccoLab's L' Aperitivo Italiano Sunset Sessions. It's bitter and twisted with the unveiling of their Aperitivi cocktail menu, designed in collaboration with Campari Australia.
More than 150 of Sydney's socialites gathered to the opening of new Mediterranean establishment, Tayim.


Our 30th Anniversary Giveaway Drawing Winner is Bruce King!
Our Photo Contest Winner is Jason Terrell!
Our season begins at the end of May. We have a combination of Alaska Halibut and Alaska King Salmon charters available out in Cook Inlet - off the Alaska Kenai Peninsula from Homer, as well as Deep Creek and Anchor Point. Alaska King saltwater fishing continues through the middle of June, while the Halibut season extends through the end of September. Our Halibut averages about 20-30 lbs., with some over 50 lbs. and occasionally you will land a monster Alaskan Halibut weighing in at 300 lbs. or more.
The King Salmon fishing on the Alaska Kenai Peninsula is from late May through the end of July, where it is not uncommon to land yourself a King 35-50 lbs. or more. Our professional Alaska fishing guides use power boats to assure you of a very peaceful and highly productive trip down the beautiful glacial Kenai River or other local Alaska Kenai Peninsula rivers. We also have drift boat fishing for Kings available on the Kasilof River during this time. The average fish caught is 15-25 lbs.
Kings are not the only fish in the local rivers of the Alaska Kenai Peninsula. The Sockeye Salmon runs can be in full swing from June through August. The limit on the fish is usually 3 fish per day. When the Sockeye enter the river in good numbers, the action gets hot and Silver runs start in August and lasts through the end of September. These fish make awesome runs and are great leapers. Fly-out fishing for all species of salmon and trout are available.
We begin fishing for huge Rainbow Trout and Dolly Varden on June 15th. Most Rainbows and Dollies average 3 lbs. with fish ranging from 8 to12 lbs. We use spin gear, light weight fishing rods and fly-fishing gear. Trips are available on the Upper Kenai River, while fishing in the comfort of a drift boat. We also fish many of Alaska Kenai Peninsula's lakes and streams.
Denise Lake Lodge offers daily fly-ins for King, Sockeye Salmon, Silver Salmon and Rainbow Trout. Join us for the trip of a lifetime on your flight across Cook Inlet in either a Turbo Otter or a Beaver on floats. Experience breathtaking scenery, glacier fields, fabulous fishing and occasionally fishing alongside Brown Bears.


Maureen Banks is the President of Spaulding Hospital Cambridge, Spaulding Hospital Cape Cod, Spaulding Hospital North Shore, Spaulding Skilled Nursing Facilities and Chief Operating Officer of Spaulding Rehabilitation Hospital and the Spaulding Rehabilitation Network. She has an extensive and varied background in nursing and healthcare leadership throughout Massachusetts, Connecticut, Virginia and New Hampshire. Maureen has held senior administrative positions in academic medical centers, home care and community hospitals. She has held faculty appointments in both graduate and undergraduate programs.
Maureen has been active throughout her career in professional organizations. At the state and regional level She is currently on the Southern New Hampshire University School of Nursing Advisory Board and has served in several capacities for the Organization of Nurse Leaders including President. At the national level, she serves on the AHA Board of Directors currently as Chairman for Governance for Long-Term Care and Rehabilitation and is active in Women Business Leaders of the US Health Care Industry. On an international level, Maureen serves on the Board of TVM Capital Healthcare, a venture capital group investing in health care opportunities.
Maureen received her MBA and Advanced Certificate in Health Administration from Southern New Hampshire University as a Commonwealth Fellow. Her undergraduate degree is from Boston College and she holds a master's degree from the University of Connecticut. As a nurse, Maureen's clinical focus has been oncology and hospice care. She is a Fellow in the American College of Healthcare Executive and recognized as NEA-BC by the ANCC.


text:
Lick It
Generic top-level domain
"Lick It" is a song recorded by American dance music group 20 Fingers featuring singer Roula. It was released in February 1995 as the second single from their album On the Attack and More. It also appears on 20 Fingers' self-titled second studio album.
The song achieved success in many European countries. It was a top ten hit in France, Austria, Belgium (Wallonia) and Germany. However, its sales were less high than 20 Fingers' previous hit "Short Dick Man". Its chart positions were especially disappointing in UK, where it stayed on the chart for three weeks and peaked at #48. The song, which was credited to Roula as vocalist, contains explicit lyrics that refer to cunnilingus.
In 1995, the mashup "Don't Laugh But Lick It" has been released as 20 Fingers & Winx feat. Roula, compromising "Lick It" with "Don't Laugh" by DJ Winx. In the Sensation White party in Amsterdam 2009, there has been released a special remix of "Lick It" with the original vocals of Roula, with go-go dancers background. In 2009, DJ Felli Fel heavily samples "Lick It" in his song "Feel It" featuring T-Pain, Sean Paul, Flo Rida and Pitbull.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Lick_It
Generic top-level domains (gTLDs) are one of the categories of top-level domains (TLDs) maintained by the Internet Assigned Numbers Authority (IANA) for use in the Domain Name System of the Internet. A top-level domain is the last label of every fully qualified domain name. They are called generic for historic reasons; initially, they were contrasted with country-specific TLDs in RFC 920.
The core group of generic top-level domains consists of the com, info, net, and org domains. In addition, the domains biz, name, and pro are also considered generic; however, these are designated as restricted, because registrations within them require proof of eligibility within the guidelines set for each.
Historically, the group of generic top-level domains included domains, created in the early development of the domain name system, that are now sponsored by designated agencies or organizations and are restricted to specific types of registrants. Thus, domains edu, gov, int, and mil are now considered sponsored top-level domains, much like the themed top-level domains (e.g., jobs). The entire group of domains that do not have a geographic or country designation (see country-code top-level domain) is still often referred to by the term generic TLDs.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Generic_top-level_domain
itisallaboutfree.com
whatisitgoodfor.net
isitart.org
rideitlikeitsstolen.net
askanditisyours.com
onearthasitisinheaven.net
itisallaboutfree.net
itisallaboutfree.org
warwhatisitgoodfor.org
warwhatisitgoodfor.net
itisallaboutopen.com
Lick It, Tom Snare
Lick It, 20 Fingers
Lick It, Support Lesbiens
Lick It, Dwarves
Lick It, Candy
You are love
You are dance
you are girl
You are tuch
You are fly
You can lie


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The death of a volunteer research subject: lessons to be learned
Richard Ian Ogilvie
CMAJ November 13, 2001 165 (10) 1335-1337;
Dr. Ogilvie is Professor of Medicine and Pharmacology at the University of Toronto and Clinical Pharmacologist with the Hypertension Unit, Toronto Western Hospital, Toronto, Ont.
A healthy 24-year-old woman died in June 2001 following participation in a research protocol involving the administration of hexamethonium bromide by inhalation and methacholine challenge.1 She was the third volunteer in a clinical trial at the Johns Hopkins Asthma and Allergy Center designed to test the hypothesis that local ganglionic blockade would suppress the bronchial protective effects of deep respiration presumed to be mediated by nonadrenergic, noncholinergic nerves releasing nitric oxide. (Normally following a period of quiet breathing, a deep breath is able to protect the airways from stimuli that cause bronchoconstriction. In people with asthma, the allergic reaction may partially disable the bronchodilator effect of deep respiration. The research protocol was designed to test whether blocking the ganglionic nerve transmission in normal lungs with hexamethonium would mimic the asthmatic response to a deep breath.) The day after being given the hexamethonium, the volunteer experienced a cough and dyspnea followed by flu-like symptoms, fever, reduced FEV1, pulmonary infiltrates, adult respiratory distress syndrome with progressive hypotension and multiple organ failure. Autopsy revealed no specific cause for the lung damage. The woman had been a technician at another laboratory at the centre that gave time off work for the experiments in addition to the usual modest honorarium.
Internal and external review panels issued reports1 that should be required reading for all clinical researchers. Research ethics boards (REBs) and regulatory agencies, hospitals and universities will probably be reviewing many of their policies and procedures to ensure the safety of all clinical trial participants, whether healthy volunteers or patients, and the disclosure of all risks before consent is obtained.
In the hexamethonium study, safety could have been improved. First, the chemical solution was not prepared by a pharmacist, and the protocol for preparation and delivery by nebulization was altered during the course of investigating the first 2 volunteers. The possible lack of sterility and enhancement of drug delivery could have compromised safety. Second, the first volunteer experienced a cough and dyspnea with deep breathing and exertion as well as reductions in measured lung function for 1 week following the hexamethonium inhalation. Without completely assessing other possibilities or discussing the event with the REB, a safety monitoring group or other researchers who had used hexamethonium inhalation, the researcher concluded that the episode was probably due to a concurrent viral infection. In hindsight, such discussions might have delayed or prevented administration of the drug to the third volunteer. Third, use of the sitting rather than the standing position to measure hemodynamic changes could have resulted in a greater blockade than achieved in previous reports.2,3,4,5 The only feasible way of assessing the completeness of ganglionic blockade is by defining the orthostatic reduction in systolic blood pressure and increase in heart rate. Postural change from lying to sitting rather than to standing may blunt the response, which would give the impression that insufficient hexamethonium had been administered.
Another component of the trial that could have been improved was the consent form. It failed to indicate that hexamethonium was not an approved drug for clinical use and had never been approved for delivery by inhalation in the United States. Risks known to the researcher were not disclosed, and it is apparent that the researcher had not carefully searched the literature and was himself unaware of some of the risks. In his study protocol the researcher cited 4 reports of studies in which inhaled hexamethonium had been given to 20 subjects without adverse events. Discussions within the medical community subsequent to the volunteer's death have unearthed an unpublished report of a possible pulmonary complication experienced by a healthy volunteer in a 1978 study in San Francisco after receiving hexamethonium by inhalation. A possible association with pulmonary toxicity was not considered until the third volunteer was admitted to hospital, when the researcher found a Web site (www.pneumotox.com) that suggested a relation to longer-term use of ganglionic blockade for the treatment of hypertension.
The Johns Hopkins investigators into this tragic event found additional reports of pulmonary toxicity published between 1953 and 1962,6,7,8,9,10,11,12,13,14,15,16 including a 1955 article in CMAJ,10 and a review article published in 197217 that were not included in the protocol submitted to the REB. Neither of the review panels felt that this information would have stopped the trial.
Could this or a similar event have occurred in Canada? Most observers would admit that it is possible, for many reasons. Volunteer members of REBs are overburdened with too many complicated protocols and pressure from researchers and outside sponsors for rapid review. Researchers may underemphasize possible adverse events in order to achieve consent. The pharmacological knowledge of medical graduates seems to have decreased over the past decade or so. Formal courses in pharmacology have been abandoned, and there are few clinical pharmacologists to ensure graduate and postgraduate expertise. Most REBs do not have clinical pharmacologists or clinical pharmacists as members to review protocols involving chemical entities. Current literature search techniques often emphasize references from the past 15–20 years at most. Older literature is often overlooked. Reports of adverse effects during clinical trials may not get published, as was the case of the hexamethonium inhalation toxicity in the 1978 San Francisco study. REBs do not have the personnel to conduct continuing reviews of clinical trials.18 Researchers, not pharmacists, often prepare and administer investigational drugs.
In Canada, there are specific rules similar to those in the United States that govern applications for permissions to conduct clinical trials. Sponsors must file a clinical trial application for phase I, II and III trials of unapproved drugs and for trials of marketed drugs whose proposed use falls outside of the approved use of the drug (e.g., changes in indications and clinical use, target patient population, route of administration and dosage regimen). Phase I trials include those in which new drugs are used as research tools to explore biological phenomena or disease processes. Hexamethonium bromide is such a drug, and thus a Canadian researcher would be obliged to make an application to use it. However, it is unclear whether a similar requirement is in place in the United States. As part of the application process in Canada, the appropriate department head of the institution where the researcher is employed would have to sign the application, which would imply that a departmental review has occurred. Unfortunately, institutions do not always conduct this review and instead rely on the REB approval mechanism. Applications must also include data on product quality and manufacturing. Not all institutions have a research pharmacist for the preparation, storage, distribution or administration of investigational drugs. In my opinion, the procedures in use in Canada to ensure high levels of safety and fully informed consent are no better than those in place in the United States. A similar event could just as well occur in this country.
The Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans19 guides the composition and mandates of Canadian REBs, including procedures for monitoring clinical research. It recommends the proportionate approach to ethics assessment so that trials involving healthy volunteers given an unapproved drug such as hexamethonium by an unusual route of inhalation would be considered high risk. In my view, this should prompt an REB to perform an additional review of the consent process and to establish a safety monitoring committee. There would be need for special attention to eliminate all possible coercion of volunteers. Despite all of these measures, however, serious adverse events may still occur.
There are many lessons to be learned from the volunteer's unfortunate death. Some changes are being made. In January 2000 Health Canada published clinical trial regulations that clarified the conduct of clinical trials as well as the role and responsibilities of REBs. They are currently undergoing review and may yet be modified.20,21 The National Council on Ethics in Human Research has been working assiduously to improve the ethical review of clinical research since 1989 and is actively promoting voluntary accreditation of REBs with increased resources and training for their activities.22 The Canadian Institutes of Health Research considers ethics to be a major accountability issue for its credibility (www.cihr.ca/about_cihr/ethics/ethics_menu_e.shtml). The voluntary, nonprofit organization, Canadians for Health Research (www.chrcrm.org), continues to inform the public at large of ethical issues.
However, in the final analysis, it will be implementation of these rules for conducting clinical trials and ensuring the safety of participants that will be most important. I believe that particular emphasis should be placed on clinical trials using drugs as pharmacological tools. Departmental or institutional review as well as REB review of protocols should always be undertaken, with enhanced review of protocols by experts in pharmacology and pharmacy, additional review of the consent process when healthy volunteers are enrolled and establishment of safety monitoring committees for high-risk protocols.
Research volunteer death [links to related documents]. Baltimore: Johns Hopkins Medicine. Available: www.hopkinsmedicine.org/researchvolunteerdeath.html (accessed 2001 Oct 12).
Holltzman MJ, Sheller JR, Dimeo M, Nadel JA, Boushey HA. Effect of ganglionic blockade on bronchial reactivity in atopic subjects. Am Rev Respir Dis 1980;122:17-25.
O'Bryne PM, Thomson NC, Latimer KM, Roberts RS, Morris MM, Daniel ED, Hargreave FE. The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. J Allergy Clin Immunol 1985;76:97-103.
Sterk PJ, Daniel EE, Zamel N, Hargreave FE. Limited maximal airway narrowing in non-asthmatic subjects: role of neural control and prostaglandin release. Am Rev Respir Dis 1985;132:865-70.
Ichinose M, Inoue H, Miura M, Takishima T. Non-adrenergic bronchodilation in normal subjects. Am Rev Respir Dis 1988;138:31-4.
Morrison B. Parenteral hexamethonium in hypertension. BMJ 1953;1:1291-9.
Morrow JD, Schroeder JA, Perry HM Jr. Studies on the control of hypertension by Hyphex II toxic reactions and side effects. Circulation 1953;8:829-39.
Corcoran AC, Dustan HP, Taylor RD, Page IH. Management of hypertensive disease. Am J Med 1954;17:383-94.
Doniach I, Morrison B, Steiner RE. Lung changes during hexamethonium therapy for hypertension. Br Heart J 1954;16:101-8.
Robillard R, Riopelle JL, Adamkiewicz L, Tremblay G, Genest G. Pulmonary complications during treatment with hexamethonium. CMAJ 1955;72:448-51.
Goldsmith HJ, Beaven DW, Kambert HP. Severe hypertension treated with hexamethonium bromide in retard medium. Lancet 1955;1:371-4.
Perry HM Jr., O'Neil RM, Thomas WA. Pulmonary disease following chemical ganglionic blockade: a clinical and pathological study. Am J Med 1957;22:37-50.
Hildeen T, Krogsgaard AR, Vimptrup BJ. Fatal pulmonary changes during medical treatment of malignant hypertension. Lancet 1958;2:830-2.
Petersen AG, Dodge M, Helwig FC. Pulmonary change associated with hexamethonium therapy. Arch Intern Med 1959;103:285-8.
Rokseth R, Storstein O. Pulmonary complications during mecamylamine therapy. Acta Med Scand 1960;167:23-7.
Heard BE. Fibrous healing of old iatrogenic pulmonary oedema ("hexamethonium lung"). J Pathol Bacteriol 1962;83: 159-64.
Rosenow EC. The spectrum of drug-induced pulmonary disease. Ann Intern Med 1972;77:977-91.
Weijer C. Continuing review of research approved by Canadian research ethics boards. CMAJ 2001;164(9):1305-6. Available: www.cma.ca/cmaj/vol-164/issue-9/1305.asp
Medical Research Council of Canada, Natural Sciences and Engineering Research Council of Canada, and Social Sciences and Humanities Research Council of Canada. Tri-council policy statement: ethical conduct for research involving humans. Ottawa: Minister of Supply and Services; 1998.
Minister Rock announces approved amendments to Canada's Food and Drug Regulations — clinical trials [press release]. Ottawa: Health Canada; 2001 June 20. Available: www.hc-sc.gc.ca/english/archives/releases/2001/2001_69e.htm (accessed 2001 Oct 16).
Regulatory amendments to clinical trial framework [information sheet]. Ottawa: Health Canada; June 2001. Available: www.hc-sc.gc.ca/english/archives/releases/2001/2001_69ebk2.htm (accessed 2001 Oct 16).
Dinsdale H. The accreditation of Canadian REBs. In: Proceedings from the NCEHR national workshop, March 25-26, 2001. Ottawa: National Council on Ethics in Human Research. Available: www.ncehr-cnerh.org/english/mstr_frm.html (select "What's New" on main menu, then "Toronto workshop" under "Proceedings from the NCEHR National Workshop") (accessed 2001/10/15).
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Developmental cysts of the brain, or arachnoid cysts, cause symptoms based upon the location and size of the cyst. Weakness, decreased cognitive performance, spontaneous hemorrhage, and seizures, are common symptoms of intracranial arachnoid cysts. Most common locations include the temporal fossa, the posterior fossa, and the suprasellar region.
Arachnoid cysts are cerebrospinal fluid-filled sacs that may develop between the surface of the brain and the cranial base or on the arachnoid membrane — one of the three membranes that cover the brain and the spinal cord. Arachnoid cysts occur mostly in males. Most cases begin during infancy but onset may be delayed until adolescence.
Untreated, arachnoid cysts may cause permanent severe neurological damage due to the progressive expansion of the cyst(s), hydrocephalus or hemorrhage (bleeding). With treatment, most individuals with arachnoid cysts do well.
Treatment for arachnoid cysts is symptomatic.
• When symptoms warrant, the surgical placement of a permanent drainage system (cystoperitoneal shunt) to remove pressure from the cyst may be required. Shunt placement is appealing due to the simplicity of the operation.
• Alternatively, an open surgical procedure to fenestrate the walls of the cyst may be performed. Cyst fenestration is typically favored due to the high success rate of this procedure.
• Endoscopic cyst fenestration is a technique that couples the minimally invasive benefits of shunting with the advantage of open fenestration by avoiding shunt implantation. It is the procedure of choice in most instances of the arachnoid cysts seen.


The final gasoline sulfur rulemaking amended 40 CFR § 80.46(a) to require the use of ASTM D 3246-96 to determine the sulfur content of butane. We did not intend to require the use of this new test method to be effective immediately. We intended that it should take effect January 1, 2004, when a butane sulfur content standard becomes effective for refiners who produce gasoline by blending butane to previously certified gasoline. Until January 1, 2004, any appropriate ASTM method may be used for testing the sulfur content of butane. We intend to take regulatory action to clarify the effective date of the regulatory butane test method.


Happy Sunday! We are heading into the last week of April already, and hopefully summer is just around the corner!
A beautiful evening walk and amazing sunset!
Loving the brighter nights with evening light streaming in and these two are certainly lapping it up!
Of course a simple bunch of fresh flowers are always a shiny moment….
Next Post Strawberry and Blueberry Chia seed pudding….


Both functional and trendy, these Black White Eyeglasses by Vincent Chase keep you ahead in the fashion-forward race. An ideal pair for the geeky and the fashionistas alike, these are great to be paired up with a classic blue jeans and a white shirt on casual days and with your corporate suits, when at work. The attractive temple design and dual black white colour combination strives a striking balance between its style and durability.
Many popular personalities from the B-town and the Tinsel town have graced rimless frames in the past. Some of them are Javier Bardem, Patrick Dempsey and Apple CEO Tim Cook. The rectangular shape of the frame and the clean lines it imparts makes this a perfect frame for round, oval and heart-shaped faces.
A style-centric pick from the rimless favourite collection Lumineers, these gracefully compliments all your attires and occasions. Flexible TR90 temples and the adjustable nose grips give a lightweight and a comfort experience to the wearer. Lumineers also brings various other rimless frames with a plethora of features so that you have something new for every day of the week and you remain with your style statement forever!