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Palace's Under-21 Fixtures Announced
Crystal Palace's under-21 side will start their Premier League Development League Two campaign with a testing trip to Sheffield Wednesday.
Gary Issot's men will make the trip to Yorkshire on Wednesday 20th August 2014 - four days after the senior squad take on Arsenal in their Premier League opener.
The Eagles' first home game of the season comes six days later, when Colchester United are the visitors to Tooting and Mitcham's Imperial Fields on Tuesday 26th August 2014.
Palace's second home fixture of the campaign, against Sheffield United on Tuesday 2nd September, will be played at Selhurst Park in a 7pm kick-off.
That is one of three games set to be played in SE25 in order to meet Premier League Development League Two rules, with clashes against Brentford on Tuesday 28th October and Cardiff City on Monday 9th March also taking place under the floodlights at Selhurst Park. Both of those matches will also get underway at 7pm.
Issott's young Eagles will be looking to improve on their 2013/14 campaign when, despite a slow start, they recovered to finish third in the league, just one point outside the play-off places which went to Queens Park Rangers and league winners Cardiff.
Just as they did last season, Palace's development side will face local derbies against both Millwall and Charlton Athletic, as well as a number of new opponents for this term including Nottingham Forest, Coventry City and Barnsley.
Crystal Palace's Under-21 Fixture List:
(All home games to be played at Tooting and Mitcham unless stated)
20/08/14 Sheffield Wednesday (A) 1pm
26/08/14 Colchester United (H) 2pm
02/09/14 Sheffield United (H)* 7pm
06/09/14 Huddersfield Town (A) 11am
15/09/14 Bristol City (A) 2pm
23/09/14 Crewe Alexandra (H) 2pm
01/10/14 Coventry City (A) 2pm
20/10/14 Nottingham Forest (A) 2pm
28/10/14 Brentford (H)* 7pm
03/11/14 Millwall (A) 7pm
10/11/14 Ipswich Town (A) 1pm
25/11/14 Swansea City (H) 3pm
09/12/14 Charlton Athletic (H) 1pm
15/12/14 Cardiff City (A) 7pm
06/01/15 Queens Park Rangers (H) 1pm
12/01/15 Colchester United (A) 7pm
27/01/15 Brentford (A) 1pm
03/02/15 Millwall (H) 1pm
09/02/15 Swansea City (A) 6.30pm
17/02/15 Ipswich Town (H) 2pm
23/02/15 Charlton Athletic (A) 1pm
09/03/15 Cardiff City (H)* 7pm
17/03/15 Leeds United (H) 2pm
23/03/15 Barnsley (A) 1pm
31/03/15 Birmingham City (H) 2pm
10/04/15 Bristol City (H) 7pm
13/04/15 Queens Park Rangers (A) 2pm
*Game to be played at Selhurst Park


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Who is Duke Dennis? Wiki, Age, Height, Net worth, Biography, Family, Birthday, Parents & More 2022
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Duke Dennis is a well-known American YouTuber, content creator, internet celebrity, online streamer, basketball player, and entrepreneur who was born on February 26, 1994. He is currently 28 years old. Duke Dennis is from the United States of America. This great guy has made quite a name for himself on Youtube with his films. According to the reports, the majority of Duke's gaming videos are published on NBA 2K.
The video game NBA 2K is a simulation of the sport of basketball, as I will now explain to you. Not only this, but Duke is also a player on the basketball team in addition to this. Over 1.82 million people are currently subscribed to his official YouTube account (as of July 2022). The information that you're looking for regarding the life of Duke Dennis can be found in this article.
This prominent YouTube personality, Duke, has gained a large following on his channel thanks to the NBA 2K content that he posts. In addition, Duke served in the United States Army. In addition to this, Duke is an active participant in the sport of basketball.
In addition to this, he worked together with a large number of well-known YouTube creators such as Kai Cenat, Fanum, Agent 00, and others. In addition, Dennis provides streaming video content on his channel on YouTube. After looking at his Instagram profile, we discovered that Duke is also a rapper. This came as no surprise to us.
Duke is a native of the United States of America, where he spent his childhood. On Saturday, February 26, 1994, he was brought into this world. Dennis is 28 years old if we are to judge his age by the date that he was born (as of 2022). Every year on February 26th, Duke and his family and friends gather to celebrate his birthday.
According to the rumors, Duke graduated from a well-known university after completing his schooling there. After that, he enlisted in the army of United States. After completing his stint in the United States Army, Dennis decided to concentrate on his profession on YouTube. In addition to that, he plays basketball at the professional level.
Full Real Name Duke Dennis.
Nickname DeeBlock.
Date of Birth February 26, 1994 (Saturday).
Age (as of 2022) 28 years old.
Place of Birth The United States of America.
Current Residence California, United States.
Profession Youtuber, Social Media Influencer, Internet Personality, Content Creator, Online Streamer, and Entrepreneur.
Net worth USD 3-4 Million (approx.).
Nationality American.
Religion Christianity.
Ethnicity Mixed.
Zodiac Sign Pisces.
Education Graduate.
School/College Reputed University.
Dennis comes from a diverse racial background and is part of their African heritage. He follows the Christian faith. Pisces is the astrological sign that he was born under. Duke does not disclose any information regarding his mother and father. Our best estimate is that Duke's father was an entrepreneur and that his mother worked in the home as a homemaker.
He enjoys interacting with members of his family when he has free time. Dennis is the older brother of two brothers who are much younger. On the other hand, we do not have access to the names of his brothers. His YouTube videos sometimes included appearances by members of his family.
Father Name Not Known.
Mother Homemaker.
Brother He has two brothers.
Sister Not Known.
Regarding Dennis's romantic endeavours, there is simply insufficient information accessible. This phenomenal YouTuber is reportedly not in a relationship, as per the sources (as of July 2022). He enjoys spending time with both his friends and his coworkers very much.
Dennis also shared a great deal of images with his friends via various social media platforms. On the other hand, he does not provide any information regarding his present relationship or girlfriend. We will make an effort to locate the information on his personal life and will provide an update as soon as possible.
Marital Status Unmarried.
Relationship Status Single.
Current Girlfriend Will Update.
Wife Not Known.
Previous Relationships Not Disclosed.
Children Son: None.
Daughter: None.
Height (approx.) In Feet Inches: 5′ 10″.
In Meters: 1.77 m.
In Centimetres: 177 cm.
Weight (approx.) In Kilograms: 80 kg.
In Pounds: 176.37 lbs.
Hair Color Black.
Hair Length Medium.
Piercing Ears.
Eye Color Black.
Tattoos He inked lots of tattoos on his hands.
Shoe Size 9 US.
Duke is a well-known internet personality as well as a professional YouTube star. After he had finished his service in the United States Army. He started paying more attention to his profession on YouTube. Since Dennis is a professional basketball player, he started playing NBA 2K, which is a video game that simulates the sport of basketball. After some time, he opened a YouTube channel and began uploading videos to it.
In addition to that, he does streaming online. On his YouTube channel, there are currently more than 1.8 million people who have subscribed to his channel. One of his early videos is titled "Angry Trash Talker," which you can watch here. In addition to that, he amassed millions of followers across all of his other social media profiles.
His professional YouTube activity brings in a significant amount of revenue for Duke. Aside from this, Duke has also begun operating his very own official website for the sale of his clothing and other merchandise. He is also an endorser for a large number of different fashion brands. A rough estimate places Dennis's wealth between three and four million dollars (approx.).
Additionally, Dennis has worked together with a large number of well-known YouTubers.
It is also possible to refer to him as DeeBlock.
Additionally, Duke posted images with a number of well-known rappers.
More than 1.3 million people are following him on his official Instagram account (as of July 2022).
On May 28th, 2021, Dennis made his debut on Instagram by posting his first image.
Facebook Click Here
Website Click Here
Wikipedia Not Found
IMDb N/A.
He is a famous Youtuber, content creator, social media influencer, internet personality, and online gamer.
How old is Duke Dennis?
He is 28 years old (as of 2022).
Why is Duke famous?
For his gaming videos and Youtube content.
Who is Duke Dennis's girlfriend?
He does not reveal any details about his partner.
How rich is Duke Dennis?
He made a net worth of $3-4 million (approx.).
What is Duke Dennis's real name?
Duke Dennis.
When Duke Dennis celebrates his birthday?
On the 26th of every February.
Facts Which Shows Kim Soo Hyun IU Relationship New 2022 Updates
Jeon Ye-bin revealed why she first denied the role of Hong Cha-Young in Vincenzo Cassano

redpajama_set_name: RedPajamaCommonCrawl


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I borrowed a book from the library, written by Ray Bradbury, called "Zen in the Art of Writing".
It's so packed with great writing advice I'm almost loathe to finish it - because then I'll have to take it back!
Writers often wonder about inspiration - and how to get good ideas for stories.
And often, when writers start out, they wonder what kind of writer they're going to be - and what kind of stories they will write, and in which genre.
Mr Bradbury has some advice on both of these issues. In the pages of his book, he explains what helped him.
He says he's been writing at least a thousand words every day of his life since he was twelve. Great. We like to hear that all the best writers have this simple habit ingrained.
He'd been reading a lot of science fiction since he was a kid he said and naturally thought he was destined to be an SF writer.
Trouble was, in his early twenties, he wasn't having much success with his SF stories. Editors complained that they were derivative and not very original. Ray agonized over this because he knew in his heart he would have to make a living from writing - there was after all nothing else he wanted to do - but how was he going to get his work published if editors weren't impressed with his stories?
He made a decision to take a couple weeks off to write down all his favorite words and phrases. Some of them intended as titles for works, some just words that he liked. Words that appealed to him and struck him as evocative.
This is the important part. He didn't just pick words that sounded good. He picked words that inspired an emotional reaction in him. The words on their own may have sounded innocuous to anyone else. Words like BODY, LAKE, CARNIVAL and DOLL. But to Ray the words personified events in his life and more relevantly, changes in his perception as he was growing up.
When he had a small notebook full of these words, he would then take one at random and write a short piece based on his personal reaction to the images and emotions triggered by them.
Hey presto, his work became, he says, more original overnight.
Original because his work became more honest, more uniquely "Ray Bradbury", he says. One of the first tales he wrote using this technique was "The Lake", a story that is still republished to this day, almost forty years later.
He said that the practice of writing down all the words he found evocative helped him to establish in his own mind what kind of writer he was. The list helped him to see patterns in his own preferences. In short, the pages of words in his notebook became the template for his "style" - his own unique way of perceiving the world.
He said what was interesting to him was that this list of words is still a source of inspiration to him to this day. Thirty years after he'd written down the list, he still plunders it for short story ideas!
So, as I said, the list became his own source of inspiration and originality at the same time. Certainly nothing to be sniffed at for a writer.
I don't know about you but this sounds like a fabulous idea - and one that may have already occurred to you. I remember being seventeen and writing down titles of books I would one day write.
I also wrote down snippets of dialogue that appealed to me. Phrases that still work their way into my stories, even now.
So if you're ever worried that you don't know what kind of writer you are, try this exercise:
Make a list of 200 words you like the sound of. Words that uniquely move or inspire you, or fill your head with images and emotions.
And when you have the list, study the words. Look for patterns.
You may discover you're not quite the kind of writer you thought you were.
Plus, you'll have a deep, ready store of inspiration.
Labels: Bradbury, getting ideas, inspiration, originality, Writing
That Competitive Edge
Don't Have Time? Change Your Mind
Writing at the Pit Face
Change the Way You Look at Things and the Things Y...


Red Oak Leak Detection: What Can You Do When a Pipe Leaks?
However, you don't just have to sit there and wait for professional service to come to your home. In the meantime, you can take action to ensure you're not wasting a single drop of water. After all, when pipes do leak, it can waste up to thousands of gallons of water the longer they go untreated, leaving you paying more on monthly water bills. While the best leak detection and repair can come from the pros, Dial One is here to show you the things you can do to when a pipe leak occurs!
Take a Stand Against Leaks Now!
Shut off Electronics: It's a universally known fact that water and electricity don't mix. If there are any electronics near the area of the leak, turn them off immediately. This includes fuse boxes, household appliances, and electrical panels. The last thing you want on top of a pipe leak is the threat of an electrical fire or shock!
Drain Water Systems: The longer you go without treating pipe leaks, the more water you waste. Drain water from any of your systems immediately to prevent pipe bursts from spilling water all over your home, which includes running faucets and flushing toilets.
Clean Up Excess Water: If you find yourself in a situation where there is a lot of excess water near the area of the leak, break out a mop and clean up! When there is water on the floor, it can be incredibly hazardous, especially if it makes the floor slippery. Also wear gloves if cleaning up any water you believe to be contaminated.
Call Your Insurer: If a pipe leaks or, worse, bursts entirely, you'll need to call up your insurance provider so you can claim any damage. Your insurer will also provide you contact information to your nearest emergency plumbing service.
Contact Dial One Johnson Plumbing, Heating & Air Conditioning to receive the best Red Oak leak detection and repair in the area!


Please check their website for more info.
For Magic Access and other Term & Conditions rates during Chinese New Year please check their website for more info.
Hong Kong Disneyland is located at Lantau Island. The best way to reach it is via MTR trail. Get off at Sunny Bay Station (Orange Line or Tung Chung Line) and hop in at the special Disney inspired train to Disneyland.
last train to hop in before reaching Disneyland!
Upon entering Disneyland, first theme to see is the Main Street. Main Street, U.S.A. is ideal for picture taking and most of souvenir shops are located here.
Few walks from Main Street U.S.A., we then entered the Fantasyland. Check out the Sleeping Beauty Castle here in fantasyland!
After tons of picture taking, we tried the Mickey's PhilarMagic 3-D adventure. The weather was really hot during our visit so we liked the idea of going inside. I enjoyed it and think it's worth a try.
Walking around, we found ourselves falling in line to take pictures with most of our favorite Disney friends.
Because we chose to have pictures with Mickey Mouse and friends first, here we were, taking our late lunch in Fantasyland. Honestly, I didn't like the taste of spareribs I ordered. But we were really hungry so we ate until we were full.
Few minutes before 3pm we waited for the Flights of Fantasy Parade here in FantasyLand.
TIP: Check Hong Kong Disneyland's website for the schedule of the parade during your visit, I just checked the website, it is now at 1pm. It is a must-see!!!
Sharing some photos taken during the Flights of Fantasy Parade. I always love parades, so colorful!
The futuristic theme of Disneyland!
We saw a long line in Autopia, being curious we found ourselves falling in line as well.
We went to Adventureland and tried out the Jungle River Cruise. I like it! We weren't able to catch Festival of the Lion King theater show here, but it must be good as well. We saw Tarzan's Treehouse which I think a great spot for kids to check out.
After the Jungle River Cruise, we looked for a spot just before the castle where we could watch the fireworks everyone wanted to see. The Tinker Bell Castle, a castle lightshow was shown first before the fireworks display.
And lastly, the highlight of our visit, the Hong Kong Disneyland Fireworks Display! What a lovely sight!
Check out my Hong Kong - Macau blog series!
thanks for this Hong Kong-Macau guide sir! It is replete with details.. Stunning shots of Firewords display btw.
hahaha,natawa naman ako sa tumawag sa yo na sir.minsan kasi nakakalito kung sino ang author ng blog lalo na kung maraming personalities ang lumalabas sa pics.
ito na ang hinihintay kong post! haha! Why on maintainance ang space mountain? sayang nmn! I rode that thrice! nakaka inlove tlga ng fireworks nila :"> and naman tong ng comment kung mka sir! haha anyway more more!
Seeing Disneyland and much more visiting it, is a trip back your childhood again, isn't it?
small world is my favorite!
as much as possible di ko talaga feel magpost ng pic ko pero minsan lagay na din baka sabihin nila di ako pumunta eh hehe!
Yes! Finally someone writes about clash of clans hack.


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F O U N D E R & D E S I G N E R
Amna Hameed, the founder of Podur has always been intrigued with fabrics and fashion having an innate understanding of structures, silhouettes and attention to detail. Having studied and graduated with a BA Interior Architecture and Design, Amna has acquired knowledge of design both through her profession and fashion, as both fashion and design compliment each other, working hand in hand to frame one another
Our clothing are inspired by the essence of timeless sophistication and refinement, illustrating the epitome of contemporary infused with tradition. Our signature aesthetic balances demiurgic with simplicity, paying attention to delicate detail, premium fabrics and empowering embroidery.
Exclusive tailoring, not only do we believe that our art is worth preserving but we are dedicated to invigorating it. Working with the finest craftsmen, we deliver the very best in sartorial elegance. A collection of modest tailoring that celebrates femininity and self-expression, our signature morale.
C O M P A N Y E T H I C S
We have set it as our mission to help others throughout our value chain. To set this in motion, we have chosen to place our production facility in a village in Sri Lanka. Countless women in Sri Lanka grow up with talent behind closed doors, which they are unable to utilize due to the conservative society that they grow up in. Our facility in Sri Lanka consists of 14 employees who are mostly young women from the local village who are extremely skilled in tailoring and craftsmenship but without the opportunity to showcase their talents. We have ensured our facility meets our team members' comfort to work by implementing company morals which respect their cultural values and family lives. Podur has proudly employed these talented young women with professional training in tailoring and pattern making, in return gaining a sense of nurturing and developing.
SOME MEMBERS OF OUR TALENTED TEAM
Sign up to our news letter for more information and latest updates


Las Vegas, NV (Jan 5, 2006) - BenQ, a leading manufacturer of digital lifestyle devices, today announced its new M310 Plus wireless optical mouse that includes a USB charging feature to eliminate the need for batteries to power the unit. Ideal for mobile professionals and laptop users, the M310 Plus features an ambidextrous style and wireless receiver that is stored within a compartment in the mouse itself.
The M310 Plus connects to a system via a USB port, requires no CD drivers and is compatible with both Macintosh and PC systems. With an integrated storage compartment and "power off" function on the bottom of the mouse, the M310 Plus, achieves greater operating time and reduces the chances of a user misplacing the receiver. The M310 Plus also automatically "powers on" when the receiver is released from the storage compartment.
The M310 Plus features an 800 dpi optical sensor, three buttons and a scroll wheel. The wireless receiver operates on a 27Mhz wavelength within RF wireless technology bands. The M310 Plus has the following dimensions: 3.5" x 1.75" x 1.25" in dimensions.
The M310 Plus is currently available with an estimated MSRP of $39 and can be purchased through authorized BenQ distribution channels.


Annette Lynch is a 2000 Beach Volleyball Olympian for Australia, using her experience and studies to inspire and mentor others to excel in business and life. Annette's greatest challenge was retirement from sport, and that journey led to her book "Success Beyond Sport". This was aimed at athletes in transition and appeals to a wider audience, teaching 8 Winning Points for Success that Apply to Life and Business. She has studied Neuro-Linguistic Programming (NLP) and has spoken on stages in UK, NZ, USA and Australia. She works with Trilogy Athletes to mentor athletes with their own transition from sport and she is here today to discuss the Olympian Mindset and how to apply that for your own success.
1. What separates Olympians from other athletes and how can that distinction be useful for business?
2. How do you mentally prepare for a match/performance?
3. What was the biggest challenge of retirement and what are the best ways to prepare for that?


Best Buy customers often prefer the following products when searching for Computerized Telescopes.
Browse the top-ranked list of Computerized Telescopes below along with associated reviews and opinions.
"The moon is stunning...Good value for the price...I ended up returning it, might be good for a beginner/intermediate astronomer but I wanted more scope...I would definitely recommend this for anyone"
"great for intermediate user...Excellent for experienced users...I would recommend this to an experienced user...Great telescope for both beginners and more advanced users"
"Great telescope for beginners...This telescope is 100% worth it...This 90slt telescope trumps that telescope any day of the week...I've also purchased a 6mm eyepiece which will allow me to view at a 208x magnification (Focal length divided by the size of the eyepiece) and I also got a variable polarizing filter by Celestron which basically increases or decreases the amount of light reflected back to the telescope"
Fully coated 90mm Maksutov-Cassegrain optics, SkyAlign and auto star alignment and a computerized altazimuth mount combine in this Celestron NexStar 90SLT 22087 telescope to expose you to the world of stargazing fun with a crystal-clear view.
"Jupiter, Saturn and Mars look great...Very impressed for a 4 inch refractor"
View the night sky clearly with this telescope that features a motorized Altazimuth mount and fully computerized hand control and NexStar Star Observer List software that lets you control the telescope via laptop or PC.
"No problems with dust...Was very easy to setup...I ordered this from Best Buy online because of the price, computerized scope, good focal length and name brand...We have yet to delve into the computer controlled star tracking, but anticipate it wont be too complicated based on our experience so far"
"Extremely pleased with this product...Great gift for the young to study the skies...I recommend watching the Celestron YouTube videos made for this scope...I can't wait to try this out in the country away from the street lights"
"Good for a beginner...Great for a beginner...I really do love this telescope I can see the moon and stars really well...I cant wait to upgrade, so I can record what I see"
"Super easy to use...So far it's great...It is a bit bulky to bring up from where I store it, but it is a great telescope for the price I paid...Easy to put together with great directions"
"My husband loves it...I have loved using it...For a first telescope I found it pretty easy to calibrate the finder scope with the main scope (follow directions)...) I am sure there are more powerful and computer gps guided telescopes for prices up into thousand dollars +"
"I love this product...My daughter loves this...I gave this a 5 not because it's the best scope of the earth, but because it's a whole lot better than I thought it would be...I ordered this item online as a Christmas gift and was extremely excited once I actually saw it in person"
"Great gift for kids...My grandson loves it...I bought it for my 12 year old cousin -- this was a good stepping stone telescope to see if astronomy really interested him or not...Nice telescope for grandkids first telescope price was good"
"The only draw back would be if you have a very compact case, the amount of cables may be difficult to fit into your case."


39 year old Textile, Apparel and Footwear Mechanic Amado from Port Hawkesbury, enjoys to spend time pets, brazil and cloud watching. Finds immense inspiration from life by visiting destinations like Himeji-jo.
This page was last edited on 24 January 2019, at 20:27.


Home » SPPI eWire 8/24/2007 » The Iris Opens Again?
Back in 2001, Richard Lindzen and colleagues made quite a stir in the climate community when they published a paper in the Bulletin of the American Meteorological Society in which they describe having possibly identified an "adaptive infrared iris" that opens and closes to keep the earth's temperature fairly steady even in light of increasing atmospheric carbon dioxide levels. It was proposed to work something like this—when the temperature in the tropical oceans begins to warm up, it causes in increase in the amount of low-level water clouds and an even greater decrease in total coverage of high-altitude ice clouds. Since ice clouds are net warmers (that is, they trap more outgoing longwave radiation (heat) than they reflect away incoming shortwave (solar) radiation) and water clouds are (generally) net coolers (reflecting back to space more incoming solar shortwave radiation than they absorb outgoing longwave radiation), more of the latter and a lot less of the former leads to a net cooling, and the temperatures of the tropical oceans decrease. However, cooler tropical ocean temperatures lead to less low-level (water) clouds and more high altitude ice clouds. This configuration tends to lead to a net radiation increase and to higher temperatures. And the cycle starts over again. Lindzen's moniker "adaptive infrared iris" refers to the mechanism in which the tropical ice cloud cover opens and closes in response to tropical ocean temperatures to allow more heat to escape to space when the oceans are warm and less heat to escape to space when the oceans are relatively cool (much like the iris of an eye which opens and closes in response to varying light levels to try to maintain a constant level falling on the retina). Lindzen et al. proposed that the iris acts as a global thermostat that will keep the earth's temperatures from rising very far even as atmospheric concentrations of greenhouse gases increase.
Needless to say, Lindzen's iris hypothesis ran into opposition soon after it was published (e.g., Hartman et al., 2002). The biggest problem with it was that it was based on temperature and cloudcover data from only a portion of the tropical western Pacific for a limited amount of time (about 20 months). Other researchers came along and declared that they could not find the iris mechanism operating in the cloud and temperature datasets that they looked at, and the idea generally fell into disfavor. Even Lindzen was forced to admit that it likely did not operate as strongly as he had initially theorized.
Nevertheless, the idea has not altogether died and research shows up in the literature from time to time that describes various efforts to look for the iris effect. The latest of these just appeared in Geophysical Research Letters. Satellite gurus Roy Spencer and John Christy teamed up again, along with colleagues William Braswell and Justin Hnilo to examine the associations between cloud cover and temperature that occur during intraseasonal oscillations that occur in the tropics. Oftentimes, tropical convective rainfall goes through a 30-60 day cycle, from suppressed to enhanced activity and then back again. Along with rainfall variations, these oscillations are accompanied by variations in atmospheric cloud cover, temperature, and circulation patterns (see here for more information on this phenomenon). What Spencer and colleagues did, was to examine the relationship between the types of cloudcover, the patterns of temperature, and the type and amount of radiation that the earth was losing to space over course of the intraseasonal oscillations. Since the surface temperature change during the oscillation is substantial, on the order of 0.5ºC during the stronger events, the accompanying changes in the other attributes, such as cloud type, may reflect the types of processes that would occur under conditions of an overall warming climate—just on a smaller time scale (weeks rather than decades).
What Spencer and colleagues found breathes new life into the iris hypothesis. Spencer's team identified an increase in low-level water clouds during the warming phase of the tropical intraseasonal oscillations, but found that while the amount of high altitude ice clouds increased initially, they unexpectedly reversed course and rapidly declined as the temperatures continued to climb. This decline in ice clouds progressed until the temperatures peaked and began to fall again. Figure 1 shows how the two types of cloud cover (water and ice) evolved over the course of the rise and fall of temperature during a composite of the nine strongest intraseasonal oscillations identified by Spencer's team.
Figure 1. (Top) Low level atmospheric daily temperature anomalies averaged over the nine strongest intraseasonal oscillations identified by Spencer et al. (2007). (Bottom) Anomalous amount of water clouds (green line) and ice clouds (blue line) for each day averaged over the same nine events. (from Spencer et al., 2007).
By the looks of it, this behavior seems much like that originally described by Lindzen, and this time it is detected in a study that is much larger in scope, both spatially and temporally, than Lindzen's original study.
The decrease in ice cloud coverage is conceptually consistent with the "infrared iris" hypothesized by Lindzen et al. , who proposed that tropical cirroform [ice] cloud coverage might open and close, like the iris of an eye, in response to anomalously warm or cool conditions, providing a negative radiative feedback on temperature change. We caution, though, that the ice cloud reduction with tropospheric warming reported here is on a time scale of weeks; it is not obvious whether similar behavior would occur on the longer time scales associated with global warming.
However, if it were applicable to the larger-scale climate picture, its impact could be substantial. Since all climate model projections of future temperature rise from increasing atmospheric concentrations of carbon dioxide predict that accompanying cloud cover changes will serve as a positive feedback that acts to enhance future warming rates, if the models had this wrong, then future warming would be substantially less than projected.
Perhaps the future isn't as dim (or, as warm, rather) as Gore and his cronies would have us believe.
Hartman, D.L., and M.L. Michelsen, 2002. No evidence for iris. Bulletin of the American Meteorological Society, 83, 249-254.
Lindzen, R.S., et al., 2001. Does the Earth have an adaptive infrared iris? Bulletin of the American Meteorological Society, 82, 417-432.
Spencer, R.W., Braswell, W.D., Christy, J.R., Hnilo, J., 2007. Cloud and radiation budget changes associated with tropical intraseasonal oscillations. Geophysical Research Letters, 34, L15707, doi:10.1029/2007/GL029698.


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19 arrested after police raid same-sex wedding in Nigeria
by David December 23, 2022 · Gay News / Gay Pride / Gay Rights / LGBTQ Nation
The Islamic police force, known as Hisbah, recently raided a same-sex wedding in northern Nigeria and arrested 19 people for attending.
In the virulently anti-LGBTQ+ country, homosexuality is illegal based on both secular and the strict Islamic legal system known as Sharia law that functions in conjunction with the government in the majority Muslim state of Kano.
Nigeria's Same-Sex Marriage (Prohibition) Act, which was signed into law by former President Goodluck Jonathan in 2014, makes same-sex relationships punishable by up to 14 years in prison. Under Sharia law, it is punishable by death.
But according to BBC, the Islamic courts of Kano have never actually convicted someone for homosexuality.
A spokesman for the police force, Lawal Ibrahim Fagge, said the 19 people who were arrested – which did not include the couple getting married, as they were able to flee – are not being formally charged with anything, but rather are being encouraged to change their "lifestyle" through "counseling."
"We'll explore the avenue of change before we charge them in court. First we counsel them, and involve the parents and we hope they change their lifestyle," Fagge said.
Fagge added that last year, Hisbah arrested 18 people at another same-sex wedding, and that they were all released after promising (in writing) to "change their lifestyle."
While no one in Kano has ever been convicted of homosexuality, those in other areas have not been so lucky,
In July, three Nigerian men were sentenced to death by stoning in a Sharia court in the northern state of Bauchi.
In response, Nollywood actor Uche Maduagwu came out as gay and called on President Joe Biden to sanction Nigeria for "ignoring the fundamental human rights" of its LGBTQ+ citizens.
"Dear President Joe Biden, we need the US government to sanction President Buhari and his top advisers over ignoring the Fundamental Human rights of #LGBT in Nigeria," he wrote in the post's caption.
Far-right Republican Marjorie Taylor Greene targeted in 'swatting' incident
Arab countries are threatening Netflix over LGBTQ content
Joe Biden warns LGBTQ+ kids will be next after Roe v Wade
Next story Why Chosen Family Is Even More Important During the Holidays
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Q: Play stop para animación de onda de sonido jquery Hola quería saber si es posible generar un rutina en jquery para darle play y stop a la animación de la onda de música, si ambos jquery que adjunte como ejemplo se pueden integrar..

var elem = $('.musica');
var count = elem.length;

var loop = function(){

  setTimeout(function(){
    elem.each(function(){
      var $this = $(this);
      var height = (Math.random() * 30) + 1;
      $this.css({
        'background': 'linear-gradient(to top, rgba(61, 175, 5,'+(.75-($this.index()/count)/2)+'),yellow)',
        'bottom': height,
        'height': height
      });
    });

    loop();
  }, 300);

}

loop();

$('#play').on('click', function(event) {
    console.log('play click clicked');
    $('#pause').show();
    $('#play').hide();
});

$('#pause').on('click', function(event) {
    $('#pause').hide();
    $('#play').show();
});
.musica {
 background: #000;
  float: left;
  height: 1px;
  margin: 20px 1px 0 0;
  position: relative;
  transition: all linear 300ms;
  width: 2px;
  -webkit-box-reflect:below -1px -webkit-gradient(linear, left top, left bottom, from(transparent), color-stop(0.35, transparent), to(white));
}

 <link href="https://maxcdn.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" rel="stylesheet">

A: Si se puede, la funcion setTimeout() la ingresamos dentro de una variable (tiempo) la cual al momento de dar click en pause se quitara el timeout con la funcion clearTimeout() y al dar play vuelves a ejecutar la funcion.

var elem = $('.musica');
var count = elem.length;
var tiempo;

 var loop = function(){
    tiempo = setTimeout(function(){
      elem.each(function(){
        var $this = $(this);
        var height = (Math.random() * 30) + 1;
        $this.css({
          'background': 'linear-gradient(to top, rgba(61, 175, 5,'+(.75-($this.index()/count)/2)+'),yellow)',
          'bottom': height,
          'height': height
      });
    });
      loop();
  }, 300);
}
 loop();

$('#play').on('click', function(event) {
    loop();
    $('#pause').show();
    $('#play').hide();
});

$('#pause').on('click', function(event) {
    clearTimeout(tiempo);
    $('#pause').hide();
    $('#play').show();
});
.musica {
 background: #000;
  float: left;
  height: 1px;
  margin: 20px 1px 0 0;
  position: relative;
  transition: all linear 300ms;
  width: 2px;
  -webkit-box-reflect:below -1px -webkit-gradient(linear, left top, left bottom, from(transparent), color-stop(0.35, transparent), to(white));
}

 <link href="https://maxcdn.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" rel="stylesheet">

A: Si, mira :
Documentation in english API Jquery:
When .stop() is called on an element, the currently-running animation (if any) is immediately stopped. If, for instance, an element is being hidden with .slideUp() when .stop() is called, the element will now still be displayed, but will be a fraction of its previous height. Callback functions are not called.
Pero traduciendotelo es :
Cuando es llamado .stop desde un elemento puedes detener su accion(animacion en este caso)
mira aqui tienes un ejemplo :

<!doctype html>

  <meta charset="utf-8">
  <title>stop demo</title>

<button id="go">Go</button>
<button id="stop">STOP!</button>
<button id="back">Back</button>

puedes utilizar la parte esta para a proyecto adaptandola de esta manera :

// Stop animation when button is clicked
    $( "#play" ).click(function() {
    console.log('play click clicked');
      $( "#play" ).stop();
    });

A: Puedes crear una variable a modo de flag con dos valores posibles, true y false. Luego le das el valor true o false desde los botones al hacer clic y en el bucle principal loop, solo mueves el gráfico si la variable es true:

var procesar = true;
var elem = $('.musica');
var count = elem.length;

var loop = function(){
  setTimeout(function(){
    if (procesar) {
      elem.each(function(){
        var $this = $(this);
        var height = (Math.random() * 30) + 1;
        $this.css({
          'background': 'linear-gradient(to top, rgba(61, 175, 5,'+(.75-($this.index()/count)/2)+'),yellow)',
          'bottom': height,
          'height': height
        });
      });
      loop();
    }
  }, 300);
}
loop();

$('#play').on('click', function(event) {
    console.log('play click clicked');
    $('#pause').show();
    $('#play').hide();
    procesar = true;
    loop();
});

$('#pause').on('click', function(event) {
    $('#pause').hide();
    $('#play').show();
    procesar = false;
});
.musica {
 background: #000;
  float: left;
  height: 1px;
  margin: 20px 1px 0 0;
  position: relative;
  transition: all linear 300ms;
  width: 2px;
  -webkit-box-reflect:below -1px -webkit-gradient(linear, left top, left bottom, from(transparent), color-stop(0.35, transparent), to(white));
}

 <link href="https://maxcdn.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" rel="stylesheet">

redpajama_set_name: RedPajamaStackExchange


text:
Korytarzyk pod Zamkiem – jaskinia, a właściwie schronisko, w zboczach Gubalca w Dolinie Kościeliskiej w Tatrach Zachodnich. Wejście do niej znajduje się w północnym ramieniu Zbójnickiej Turni opadającym do Wąwozu Kraków, w pobliżu Jaskini pod Zamkiem, na wysokości 1186 metrów n.p.m. Jaskinia jest pozioma, a jej długość wynosi 7 metrów.

Opis jaskini
Jaskinię stanowi poziomy, ciasny i prosty korytarzyk zaczynający się w niewielkim otworze wejściowym, a kończący szczeliną nie do przejścia.

Przyroda
W jaskini brak jest nacieków. Ściany są suche, nie ma na nich roślinności.

Historia odkryć
Jaskinia była prawdopodobnie znana od dawna. Jej pierwszy plan i opis sporządziła I. Luty przy pomocy M. Kowalskiej i M. Kropiwnickiej w 1987 roku.

Przypisy

Jaskinie polskich Tatr
Jaskinie Tatr Zachodnich

redpajama_set_name: RedPajamaWikipedia


Carwyn Jones former First Minister of Wales at the 2018 Labour Party annual conference.
In 1997, the Welsh people narrowly vote to create a Welsh Assembly to devolve powers away from Westminster in a national referendum. For years, the Conservative party had called for a second referendum to overturn the first, which won by just under 7,000 votes, but they were rebuffed.
On the latest episode of Changed My Mind, the former First Minister of Wales Carwyn Jones talks about how he initially felt that the 2016 Brexit referendum should be final, but eventually came to support the idea of a second vote.
For our post-interview discussion, regular hosts Ali Goldsworthy, Laura Osborne and Alex Chesterfield were joined by Steve Martin, behavioural scientist and best-selling author, and Rob Blackie, one of the UK's top digital strategists. They discuss whether facts alone are enough to change people's minds.
WhatsApp Democracy comes to India!


Alcohol Drug Class™ is a national and global provider of online educational programs in the field of alcohol and substance abuse. Owned and operated by parent company, AJ Novick Group, Inc., they have been providing distance learning education since 2003. Alcohol Drug Class™ has recently added a new 12 hour / session (Level 2) drug and alcohol awareness class to it's list of online programs used for court ordered requirements, corporate and business needs, probation, as well as family and personal needs.
Founder and president of Alcohol Drug Class™, Dr. Ari Novick states, "We are pleased to offer this new program as part of our total class offering. We had only offered this program to certain states and now offer to all potential customers". This new 12 hour (level 2) drug and alcohol awareness class offers the same robust content as it's 16 hour, level 2 counterpart, but in a slightly more condensed format. The 12 hour class is ideal for those with either a 12 session, week, or 3 month requirement.
Alcohol Drug Class™ also offers a variety of other online drug and alcohol awareness classes including minor in possession class in several lengths including 8, 12, 16, and 24 hours. Dr. Novick states, "We have created a solution for taking high quality, low cost and effective drug and alcohol awareness classes in an educational format so that potential consumers don't have to miss time away from work, school or other commitments".
Alcohol Drug Class™ provides courses online from any location in the world with a computer and Internet access. More information can be found by contacting the company.


text:
Giancarlo Antognoni (Marsciano, 1 april 1954) is een voormalig Italiaans voetballer. Hij speelde op het middenveld een spelbepalende rol. Hij begon zijn carrière bij Astimacobi. Vervolgens speelde hij het grootste gedeelte van zijn loopbaan bij Fiorentina, om af te sluiten bij het Zwitserse Laussanne-Sport. Met Fiorentina won hij in 1976 de Coppa Italia.

Interlandcarrière
In 1982 werd hij wereldkampioen met Italië. Antognoni speelde 73 interlands voor Italië en maakte zeven interlandgoals. Hij maakte zijn debuut voor de nationale ploeg op woensdag 20 november 1974 in de EK-kwalificatiewedstrijd in en tegen Nederland (3-1).

Erelijst
 Fiorentina
Coppa Italia
1976

 Wereldkampioen'''
Spanje 1982

Zie ook
Lijst van spelers van ACF Fiorentina

Externe link
 De site van Giancarlo Antognoni.

Italiaans voetballer


text:
Idea & Design Works
Rodriguez, Gabriel
Illustratör/Fotograf
chiefly col. Illustrations
Volymtitel
Volume 1 Locke & Key, Vol. 1 Welcome To Lovecraft Welcome to Lovecraft
Locke &; Key, Vol. 2 Head Games
Locke &; Key Slipcase Set
Locke &; Key Master Edition Volume 2
Locke &; Key, Vol. 6 Alpha &; Omega
Locke &; Key Heaven And Earth
Locke &; Key, Vol. 4 Keys To The Kingdom
Locke &; Key, Vol. 5 Clockworks
The Cape: Fallen
Locke &; Key Vol. 1: Welcome To Lovecraft
av Joe Hill
(4 röster)
Fri frakt inom Sverige för privatpersoner.
Locke & Key tells of Keyhouse, an unlikely New England mansion, with fantastic doors that transform all who dare to walk through them, and home to a hate-filled and relentless creature that will not rest until it forces open the most terrible door of them all! Acclaimed suspense novelist and New York Times best-selling author Joe Hill (Heart-Shaped Box) creates an all-new story of dark fantasy and wonder, with astounding artwork from Gabriel Rodriguez.
De som köpt den här boken har ofta också köpt Locke &; Key, Vol. 3 Crown Of Shadows av Joe Hill (häftad).
Fler böcker av Joe Hill
Visa alla böcker av Joe Hill »
"A modern masterpiece..." -- AV Club "It's great! ...The art here by Gabriel Rodriguez is some of the finest stuff in comics today... The team of Hill and Rodriguez is top notch!" -- Blair Butler, Fresh Ink "Solid pacing and plot twists, combined with Rodriguez's clean lines and detailed pencils make Locke & Key a lock for best horror book of the week." -- Wizard Magazine "In a year of auspicious comics debuts, Joe Hill turned in one of the few comics that truly came from a different place. Written with skill that makes me jealous, courage that makes me smile, and honesty and brutality that makes me want to see what comes next. Okay, I'm officially a fan." -- Ed Brubaker "A modern suspense thriller meets something more wondrous and magical." -- IGN
Joe Hill is the #1 New York Times bestselling author of Full Throttle, The Fireman, Heart-Shaped Box, and NOS4A2, recently made into a TV series from AMC. His horror novella In the Tall Grass, co-written with Stephen King, was made into a feature film from Netflix. His book of short stories, 20th Century Ghosts, won the Bram Stoker Award and British Fantasy Award for Best Collection. He earned the Eisner Award for Best Writer for his long-running comic book series, Locke & Key, featuring the eye-popping art of Gabriel Rodriguez. Born in Santiago, Chile, Gabriel Rodriguez began working as an illustrator in the late 90s and in 2002 started drawing books for IDW Publishing, including CSI, George Romero's Land of the Dead, and Beowulf, amongst others. In 2007, he co-created the award-winning series Locke & Key with Joe Hill. He continued developing other creator-owned projects: the Eisner-winning Little Nemo: Return to Slumberland, with Eric Shanower; Sword of Ages; and the gritty sci-fi adventure Onyx, with Chris Ryall. In 2019, he partnered with Hill once again for two new Locke & Key stories, "Dog Days" and "Nailed It."


text:
FREE books, reports, seminars, and more detailing how to avoid major estate planning and asset protection planning mistakes in North Carolina
Carolina Family Estate Planning offers a variety free resources on including books, reports, e-courses, newsletters and more on estate planning, long term care planning, Medicaid, VA benefits, Alzheimer's care, protecting minor children, and more to North Carolina residents in and around Cary, North Carolina and surrounding communities.
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If you are hiring the venue you are welcome to bring all your own drinks. However if you are booking a styled event please be advised we will provide Tea, Coffee, and a selection of cold beverages so all you need to bring is your bottle of preferred bubbly!
Is this a family friendly venue?
Can I view the venue?
We are happy to reschedule your event due to weather if more than 10 business days notice is given. If you would prefer not to reschedule your event we can provide a marquee to ensure your guests stay dry!
Are Taxis and Ubers available?
Can you cater for dietary restrictions?
Yes! We have gluten free, vegetarian and vegan options. Contact us with your dietary requirements and we'll let you know what we can do.


text:
W Wilkins - "Explicito" [Lyric Video]
on September 18, 2021 Video No comments
Check out the hot new single "Explicito" from W Wilkins!
Watch the new lyric video below and click here to stream on your favorite platform - https://orcd.co/explicito
SIGUE W WILKINS EN:
IG: http://www.instagram.com/wwilkins1 FB: https://web.facebook.com/wwilkinsmusic/ TL: https://twitter.com/wwilkinsmusic TK: https://tiktok.com/@wwilkinsmusic
Toronto-Based Latin-Pop Artists MellyQueen & Skyzz Set the Night Ablaze with "Lento y Pegadito"
This simmering late-summer heat is no match when it comes to heating up the room like Latin-pop artists MellyQueen and Skyzz do on their fresh track, "Lento y Pegadito" — available now!
Driven with poppy composition, enticing vocalizations, and some undeniable musical magnetism, the two Toronto-based multi-talented artists soar beyond the stratosphere with their newest single — and first collaboration.
"When Skyzz and I met, we shared a great connection and an overall chemistry," MellyQueen recalls. "We really wanted to create a song that captured that fun, heartfelt, and feel-good energy we share off-camera."
"Lento y Pegadito" ignites these vibes ablaze; tied together with the track's accompanying video, audiences are treated to witnessing the pair's electric creative chemistry first-hand. "Unlike its title, the love for this single has been quick and expansive among the Latin community," Skyzz says.
"Through this experience, we were able to work as creatives — learning from one another, and creating an amazing final project," MellyQueen continues. "Knowing this was our first collaboration, we spent many days perfecting the lyrics, production, and video to showcase the beauty behind this project.
"We believe we have created something different and special for our audience."
To that end, the two Toronto-based artists have grown increasingly known for creating musical magic for their audiences within their own respective careers for some time now.
Skyzz is an award-winning Latin-pop, Afrobeat, Hip Hop, and alt-rock singer/songwriter from Belize. From his first grasp of a pair of drumsticks at a young age, to being named CJ107's Most Talented Performer in 2017, Skyzz is known for his scintillating blend of vigorous passion and infectious persistence — all wrapped within deeply healing and relatable lyrics derived from personal experiences.
Produced by Alix Veliz ("Dancing Kizomba"), Skyzz's 2021 forthcoming debut EP is set to include a selection of his new and original singles, such as "Bésame," "Let Go Let Love," "What Do You Want," "Congratulations," and more.
Specializing in Latin music, MellyQueen fuses Spanish and English lyrics effortlessly — garnishing her productions with a dazzling dashes of pop and reggaeton.
While she released her first single, "Goodbye," in February of 2020, this indie artist is no stranger to music and the creative process; MellyQueen has been making music since a young age — learning to write lyrics and create melodies. She prides herself on her ability to inspire her listeners while leaving them with a feeling of buoyancy and willingness to get on their feet and dance.
Skyzz and MellyQueen's new single, "Lento y Pegadito," is available now.
Prince Royce Takes Over Tropical Radio with "Lao a Lao"
on September 03, 2021 No comments
Award-winning multiplatinum superstar and global bachata idol PRINCE ROYCE continues to generate hits in his fenomenal career; this time his brand new single "Lao' a Lao'" is taking over tropical radio in the USA and Latin America. The track has debuted at #1 on the Billboard Tropical Airplay chart in the USA & Puerto Rico marking his twenty-first #1 on the chart. The song also reached #1 in the Dominican Republic's bachata chart as well as on Colombia, Chile, Ecuador and Panama's tropical charts. In its first week out, "Lao' a Lao' " has already notched at #16 on Billboard's Latin Airplay chart.
"I am happy and grateful seeing how people have connected with this song. It's what an artist hopes for. As always, thank you to my fans for their unconditional support and to everyone at radio for playing my music," Royce expressed.
Royce holds the record for the longest-running Billboard Latin Airplay #1 with "Carita De Inocente", which topped the chart for 29 weeks, a feat that earned him a Guinness World Record.
The multiplatinum artist will perform "Lao' a Lao'" live on stage for the very first time at the 2021 Billboard Latin Music Awards. Royce has five nominations, which include:
TROPICAL ARTIST OF THE YEAR, SOLO
TROPICAL ALBUM OF THE YEAR (ALTER EGO)
LATIN AIRPLAY SONG OF THE YEAR ("Carita de Inocente")
TROPICAL SONG OF THE YEAR ("Carita de Inocente")
TROPICAL SONG OF THE YEAR ("Lotería").
The prestigious awards will be broadcast live from Miami, September 23rd, on the Telemundo Network.
"Lao' a Lao'" is the first single off Royce's upcoming album, set to be released in 2022. It was written and produced by Prince Royce alongside longtime collaborator D'lesly "Dice" Lora, George Noriega, Miguel Muñoz and Giovanny Andrés Fernandez Manzu.
The track has over 6 million streams across digital platforms. Click HERE to stream or download "Lao' Lao'" and HERE to watch its music video.


text:
AT.prototype.setGap = function () {

	var self = this,
		i,
		target;

	self.gap = [];

	for (i = 0; i < self.targetList.length; i++) {

		target = self.targetList[i];

		self.gap[i] = {
			// Attention: converting the target radius using the x-axe;
			// otherwise an error will occur
			top: self.convertTo.canvasY(target.center[1]) -
				self.convertTo.canvasX(target.diameter / 2),

			left: self.convertTo.canvasX(target.center[0] -
					(target.diameter / 2))
		};

	}
};

redpajama_set_name: RedPajamaGithub


Do you rock an Aguilar Tone Hammer 350 bass head? You know how you can keep your head protected on the way to the gig? With the Aguilar Tone Hammer 350! Carry Bag This tough, good-looking cover is designed to fit Aguilar's Tone Hammer 350. It's exterior is durable Cordura nylon, and it has a padded plush interior. You've got an awesome pro bass head. GearNuts says be smart and protect it against dust, scratches, and the elements - with the Aguilar Tone Hammer 350 Carry Bag!


text:
module Types
  class ProgressEpisode < Types::BaseObject
    field :number, Integer, null: false
    field :completed, Boolean, null: false
    field :collected_at, String, null: false
  end
end


I am not a huge American Idol fan. I mean I've watched it and even cheered on some of the singers...but I don't like the playing of musical chairs with the judges. It gets old.
Last season this was one of the guys to watch. He's good. Phillip Phillips wasn't my fave but I liked his voice. This song, Home, has a really great sound too it. It sounds kinda earthy and deep.
You can get the mp3 single at Amazon for only 99 cents!


Nursery in a nursery with this beautiful botanical sanctuary floral pattern decorative pillow.Botanical Sanctuary Multicolor Dec Pillow measures 12"x16", Boudoir soft decorative cushion with pearl string in multicolor.Cotton percale shell with 100% Polyester lofty fill. Removable fillers. Machine washable.Coordinates with other pieces in the Bacati Botanical Sanctuary Pink Crib Set.


Copyright: © 2012 Groh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: There are no funders in this Clinical Symposium work.
A 33-year-old man living in Cayenne, French Guiana, was admitted in the Bichat hospital in Paris with a 3-week history of fever associated with dyspnea and confusion. A chest X-ray previously made in French Guiana showed an alveolar infiltrate of the middle lobe. Amoxicillin and then doxycycline were administered, but did not alleviate the symptoms. Physical examination revealed a loss of 4 kilograms in the last month, confusion, hypotension (98/63 mmHg), tachycardia (126 beats per minute), a red but painless left eye, congestive heart failure, fine crackles in the right lung field, and a one-centimetre-wide left axillary node.
Haematological blood tests revealed a haemoglobin level of 137 g/l with signs of haemolysis (elevated lactic dehydrogenase, low haptoglobin), a total white blood cell count of 11.1×109/L (69% granulocytes, 21% lymphocytes), and thrombocytosis (392×109/L platelets). The blood film showed stigmata of mononucleosis syndrome. Blood chemistry revealed hyponatremia, mild hepatitis, pancreatitis, and elevated cardiac markers. Table 1 summarizes biological data.
Electrocardiogram showed sinus tachycardia. Transthoracic echocardiography revealed an altered left ventricular ejection fraction (35% estimation with Simpson's method), global hypokinesia, but no signs of endocarditis. Abdominal computed tomography (CT) scanner was normal.
What Further Investigations Would You Perform to Make Etiological Diagnosis?
There are many diagnoses that can lead to subacute fever, hepatitis, pancreatitis, and pneumonia in a patient coming from the Amazonian region. Blood cultures, thick and thin smears for malaria, and intradermal purified protein derivative test for tuberculosis were negative. Mycobacterium tuberculosis was not detected on gastric aspirates. Urines were sterile, and antigen detection for Streptococcus pneumoniae and Legionella pneumophila was negative. HIV, hepatitis viruses (A, B, and C), Coxiella burnetti, Rickettsia conorii, Salmonella typhi and paratyphi, Brucella sp., Dengue fever, and Mumps virus serologies were also negative. Chlamydia pneumoniae and Mycoplasma pneumonia serologies were positive with the presence of both IgM and IgG. Epstein-Barr virus (EBV)-IgM and IgG anti-VCA antibodies were also found, but detection of EBV and Cytomegalovirus (CMV) DNA by polymerase chain reaction (PCR) was negative. Since the patient had severe cardiac dysfunction, Chagas' disease was also looked for, but antibodies against Trypanosoma cruzi were absent. Cerebrospinal fluid analysis revealed 8 cells/mm3, hypoglycorrhacchia (2.3 mmol/L with venous glycaemia 5.5 mmol/L), hyperproteinorrachia (0.54 g/L), sterile culture, and negative pneumococcal and cryptococcal antigen detection. Toxoplasma gondii, Herpes simplex viruses (type-1 and -2), EBV, and Varicella-zoster virus DNA were not detected by PCR in the cerebrospinal fluid.
What Finally Led to Diagnosis?
The patient reported the consumption of semi-raw game (Brazilian Tapir, Tapirus terrestris, locally known as Maïpouri) 3 weeks before the beginning of symptoms, pieces of which were still kept frozen.
Ophthalmologic examination showed a cornea ulcer associated with multiple foci of retinochoroiditis in the left eye, which is suggestive of toxoplasmosis.
Systematic exploration of the causes of mononucleosis syndrome led (besides HIV, EBV, and CMV serologies) to T. gondii serology, which was positive with the presence of IgG (63 IU/ml), high levels of IgM (index of 42.7, Vidia Biomerieux), and IgA (12/12 with ISAGA Biomerieux test). The avidity of anti-toxoplasmic IgG was low (4% Vidas Biomerieux). These data suggested recent toxoplasmosis infection. Table 1 summarizes serological data.
How Can Hyponatremia and Hemolysis Be Explained?
Since blood osmolarity was low (259 mosmol/L) and urine osmolarity was high (508 mosmol/L), the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was suspected. Cortisol response to synacthen test and level of serum thyroid-stimulating hormone were normal. No medication causing hyponatremia as a side effect was taken. Brain magnetic resonance imaging was normal, and full-body CT scan did not suspect cancer. SIADH diagnosis was confirmed and related to pneumonia.
There were no schizocytes on the blood film. Direct Coombs' test and hemoglobin electrophoresis were negative or normal. Pyruvate kinase deficiency and Minkowski-Chauffard disease were also looked for but excluded. Glutathione stability test revealed mild g6pd deficiency (7% g6pd activity). The patient, though living in French Guiana, was of Chinese descent, and g6pd deficiency is frequent in Asia. Amoxicillin and doxycycline are suitable for g6pd patients, and we can imagine that sepsis favored haemolysis.
How Would You Manage the Patient?
When C. pneumonia and M. pneumoniae serologies came back positive, macrolide therapy (roxithromycine 300 mg/day) was started. However, physicians doubted that these serological data could explain the whole symptoms. Three weeks after the first serologies, C. pneumonia and M. pneumoniae antibodies' rates did not rise, pointing out a cross-serological reactivity with T. gondii antibodies.
Since the patient was in a critical condition and despite mild g6pd deficiency, gold standard anti-toxoplasmosis treatment  was promptly started after the serological diagnosis of recent T. gondii infection. The patient's condition improved with pyrimethamine (100 mg/day for the first 2 days followed by 50 mg/day), sulfadiazine (6 g/day), and folinic acid (25 mg/day). There was no increased haemolysis with sulfadiazine, but this drug was stopped and replaced by clindamycin (2.4 g/day) due to hepatotoxicity. Anti-Toxoplasma drugs were given for a total of 6 weeks.
A salt-free diet, furosemide, and increased doses of perindopril and bisoprolol were also administered. Heart rate diminished, congestive heart failure symptoms disappeared, and brain natriuretic peptide and troponin levels normalized. Periodic transthoracic echocardiogram evaluations were performed and LVEF measures reached 45% at the patient's discharge.
When furosemide was stopped, and thanks to fluid deprivation, natremia normalized. The patient recovered his full intellectual abilities.
With anti-Toxoplasma treatment and Vitamin A ointment, cornea ulcer and chorioretinitis healed without visual aftereffect.
Lipase rose to 17N but decreased under antiparasitic therapy.
A quantitative PCR-based assay detected the 200- to 300-fold repetitive 529 bp DNA fragment of T. gondii in a blood sample collected 3 days after admission. This blood sample was also inoculated into mice. Four weeks post-inoculation, all mice tested positive for T. gondii antibodies and showed signs of disease due to a virulent T. gondii strain.
All surviving inoculated mice were sacrificed and numerous T. gondii cysts were microscopically observed in the brain samples. Cell cultures were inoculated with trypsinized cysts of T. gondii, and the strain was named BRC TgH41001.
Genotyping analysis with 15-microsatellite markers  of the BRC TgH41001 strain was performed on DNA extracted from cysts collected at first isolation in mice. In each pair, one primer was 5′-end labelled with fluorescein (6-FAM, HEX, or NED) to allow sizing of PCR products with an automatic sequencer. PCR was carried out in a 25-µL-reaction mixture consisting of 12.5 µL of 2X QIAGEN Multiplex PCR Master Mix (Qiagen) and 5 pmol each primer. Cycling conditions were 15 min at 95°C, 30 s at 94°C, 3 min at 61°C, 30 s at 72°C (35 cycles), and 30 min at 60°C. PCR products were diluted in desionised formamid with a dye-labeled size standard (ROX 500, Applied Biosystems) and electrophoresed using an automatic sequencer (Abiprism 3100, Applied Biosystems). The sizes of the alleles in base pairs (bp) were estimated using GeneMapper analysis software (version 4.0, Applied Biosystems).
Total DNA was extracted on eight samples of the frozen Maïpouri meat and submitted to a quantitative PCR-based assay targeting the 200- to 300-fold repetitive 529 bp DNA fragment of T. gondii, but only one tested repeatedly positive for T. gondii DNA at low concentration (cycle thresholds of 35.74 and 36.05). The genotyping analysis with 15 single-copy microsatellite markers was attempted on this positive DNA sample but was unsuccessful because the amount of T. gondii DNA was too low for a successful amplification of the genetic markers.
The genotyping data of the BRC TgH41001 strain and 12 reference strains are reported in Table 2. Phylogenetic analyses of T. gondii strains have shown that those from the French Guianan rainforest are of special significance because they are genetically highly divergent from the ones found elsewhere in the world  and even from those circulating along the coastline of French Guiana . The genotyping analysis of TgH41001 strain supports this viewpoint. This strain possesses a specific combination of microsatellite alleles (such as alleles 203 and 246 at TgM-A and W35 markers, respectively), which to date has been described only in the atypical strains from the Amazonian rain forest (Daniel Ajzenberg, personal communication).
Table 2. Genotyping results of BRC TgH41001 strain and 12 reference strains with 15 microsatellite markers.
Why Was the Patient's State So Severe?
One of the evolutionary strengths of T. gondii is its ability to adapt its reproductive behaviour in different environments. In North America and Western Europe, it benefits from ancient agricultural habits of breeding of a limited number of species, which provide a stable environment. The latter is ideal for asexual reproduction, thus leading to clonal propagation of a few successful lineages . In these areas, 95% of T. gondii strains belong to three main lineages named type I, II, and III.
On the contrary, the Amazonian rainforest ecosystem is a hotbed of diversity. In order to survive in such an environment, T. gondii uses preferentially sexual reproduction in wild felids' gastrointestinal tract to generate atypical strains with highly divergent genotypes . The report of an atypical T. gondii strain isolated in a free-living jaguar in French Guiana supports the existence of a T. gondii wildlife cycle and then genetic diversity . Since 1998, several severe (and sometimes lethal) cases of acute toxoplasmosis in immunocompetent subjects involving such strains have been reported in French Guiana –. They disseminate via parasitaemia to multiple organs and especially to the lungs .
So far, there are only epidemiological and clinical data  supporting the fact that atypical Guianan strains are more virulent in immunocompetent patients than other T. gondii strains. Their high genetic diversity may provide them with enhanced invasive abilities, or it could interfere with the Th1 host immune response, as suggested by experiments in mouse models –. However, evidence has also been given indicating interindividual variability after infection to a same Guianan strain in an outbreak . Biochemical mechanisms of virulence have not yet been studied in humans, but experimentally, ROP proteins seem to be essential for invasion and maintenance of the parasitophorous vacuole membrane. It has been shown that the overexpression of ROP18 or the transfection of the ROP18 allele into a nonpathogenic T. gondii strain enhances mortality in a mouse model –. Further studies, such as the ROP18 gene sequencing of atypical Guianan strains, would be of high scientific value.
There is no formal evidence that the Maïpouri meat was the source of infection. Nonetheless, many strong arguments support this view. First, previous studies  demonstrated that consumption of game from the Amazonian forest was strongly associated with the risk of developing 10 to 20 days later severe toxoplasmosis. Second, we have proved that there was T. gondii DNA in the Maïpouri sample. Third, the patient ate undercooked meat, which makes highly likely the fact that he ingested living T. gondii cysts. Finally, and despite thorough questioning, we could not identify any other potential source of T. gondii infection. The patient was living in an urban area, without any pets, and has never travelled to the Amazonian rainforest. He drank only boiled water and did not report any other raw-meat consumption in the month before the beginning of symptoms besides the Maïpouri steak. To our knowledge, evidence has never been published demonstrating that a piece of meat was the source of human Toxoplasma infection by matching the parasite's genotype from the patient's biological sample and from a piece of meat likely to be the source of infection.
Among the five people who shared the Maïpouri dish, only two ate undercooked meat: the patient and his father. The latter remained asymptomatic, but he refused to perform a test to check his serological status against toxoplasmosis. Only hypotheses can be made to explain why he remained healthy. Either his steak was free of T. gondii cyst or most probably, thanks to his age, he was already immunized against toxoplasmosis.
In medical practice, T. gondii is mainly a health concern in pregnant women and in immunosuppressed patients. In immunocompetent patients, acute toxoplasmosis is generally asymptomatic or associated with benign symptoms such as prolonged fever, polyadenopathy, and myalgia. Severe complications, such as pneumonia, myocarditis, or meningo-encephalitis, are infrequent. Eye involvement is likely underestimated, and the burden of ocular toxoplasmosis seems to be extremely high in certain tropical areas of South America .
To date, more than a hundred cases of acute toxoplasmosis in immunocompetent patients (adults and children) due to atypical strains of T. gondii have been reported in French Guiana (M. Demar, personal data). Approximately 40 have been published. It is highly likely that these atypical and virulent strains of T. gondii also exist in other Amazonian countries than French Guiana, but clinical cases are probably underreported.
Physicians should systematically consider acute toxoplasmosis as a possible diagnosis for any infectious syndrome with visceral (especially lung) involvement in patients who have recently travelled to or lived in the Amazonian area. Since lethal cases have been reported and since treatment associating pyrimethamine and sulfadiazine is efficient, such treatment should be promptly started immediately after serological results, without waiting for positive PCR or parasitic isolation.
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