People assume that hard work alone is all they need to succeed. I would argue that's not quite true. My success in business, and in particular at Herjavec Group, has been achieved with a mix of careful preparation, calculated risks, the development of a world-class team and, of course, a dose of good luck. It has NOT by any means been achieved by idleness.
Time and time again we hear the analogy between climbing a mountain and the road to success: Life is a lot like climbing a mountain, with the ultimate prize of success (whether it be monetary, career, or interpersonal) waiting at the top.
Assuming you want success badly enough, you start climbing, taking risks along the way. You plot each step, consider each handhold, and measure each crevasse to make sure you can leap safely to the other side. Each step you take brings you closer either to success or failure.
There comes a time when climbers on their way to the top reach a critical juncture and are faced with three options.
Retreat: If you decide that a barrier can't be overcome, you can abandon it entirely. Retreating does not always mean failure. Quite often we should return to ground level to reassess the situation and come up with a better plan of attack.
Take a Calculated Risk: Accept that there is a chance you will fail to make the leap across a chasm, or the rock you are about to step on may crumble, but understand that the rewards far outweigh the risk.
Do Nothing: This is all too common among those who are not fully committed to success — in a word, you freeze. Unable or unwilling to back down, and unable to take the risk that will keep you moving upward, you remain somewhere in the limbo between total success and ultimate failure. One is inaccessible, the other intolerable.


Welcome to Danielle Nardi Yoga!
I'm a Doctor of Physical Therapy and 200-hour vinyasa trained yoga teacher specializing in teaching yoga for athletes and adaPTed yoga for individuals with a variety of mobility considerations. I believe that everyone can benefit from yoga and I hope to continue to work to make yoga accessible to everyone!
I currently live on Cape Cod where I work as a physical therapist incorporating my background in yoga for overall mind-body wellness. You can find my current class and workshop schedule HERE or e-mail for private session information.


Online Entry system is ready for use by everyone.
No more printing, filling, scanning and emailing in your entries!
If you have previously attended one of our coaching/track or race events then email webmaster@motorcyclesportsmen.com.au with your name, email address and phone number and we will provide you with your login details.
Enjoy hassle free event entry and online credit card payments.


We are delighted to announce that Sunreef Yachts will exhibit its most popular yacht model, the Sunreef 62 Sailing, at the incoming HAINAN RENDEZ-VOUS in April 2011. The boat was delivered to its Chinese client in November 2011 and her permanent location is Sanya, Hainan.
Sunreef Yachts will be exhibiting in conjunction with its exclusive broker for China, Speedo Marine. The successful cooperation between two companies results in a strong promotion of the Sunreef brand in China and first sales concluded a year ago. Soon more luxury catamarans will sail on Chinese waters.
Sunreef Yachts will be promoting its range of sailing and power luxury catamarans with a special focus on two new models for 2011: the Sunreef 58 Sailing and the 60 Sunreef Power, both already under construction in the shipyard.


Moved: 1st Mini purchased last week...time for a deep clean!
Vin number and other stuff !
Where's my Mini in production?
132 Attachment(s) 2016 Cooper S 4 door - returned to shipper?
3 Attachment(s) Awaiting Transport -> En Route?
How long are Roadsters taking to get into production/delivery?
Any guess on my ETA? On the dock awaiting a shipping vessel.
2 Attachment(s) Picked Up Yesterday Afternoon!


Onward Healthcare is seeking qualified registered nurses (RNs) interested in working temporary and travel nursing jobs in Iowa. Read on for a list of Iowa nursing resources, as well as a rundown of what to expect when you travel to the Hawkeye State.
Travel nurses are in high demand in Iowa, with hospitals and healthcare facilities actively seeking experienced RNs to work temporary assignments. The state slogan is "the Land of Opportunities," and this is especially appropriate when it comes to nursing jobs in Iowa.
A wonderful place to work, play and live, Iowa is a charming state cradled between two rivers — the Missouri on the west and the mighty Mississippi on the east. Located in the center of America's heartland, Iowa is a diverse state with thriving communities immersed in history and natural beauty.
Iowa is definitely a state for outdoor and nature lovers. Biking, golfing, and hiking are just a couple of ways to spend an afternoon. However for those who do prefer indoor activities, check out the floating casinos on either of the two rivers that glide past the eastern and western regions of the state.
Ready to Travel to Iowa?
No matter what your nursing specialty, Onward Healthcare can connect you with the Iowa nursing job that best suits your personal and professional goals. Begin your online nursing application and start your next nursing job search today!
Iowa travel nursing jobs from Onward Healthcare. © 2018 AMN Healthcare, Inc. All rights reserved. Reproduction and distribution of these materials is prohibited without the expressed written authorization of AMN Healthcare, Inc.


We offer other Permit Plans memberships.
In the next step, you'll be prompted to select your plan.
Become a member of the CCW Safe Defender with $1MM bond & Civil Liability Program.
This CCW Safe Defender Plan with $1MM bond coverage and Civil Liability Protection Covers a Concealed Carry Permit holder for any criminal, civil or administrative legal action stemming from a self-defense incident. This plan is non-transferrable. The Primary member must either have a resident or non-residentconcealed carry permit (Does not include FOID cards). All permits must remain valid. The Primary member will be covered (up to $1MM bond) for all legal use of force responses to life threatening attacks at your home, your vehicle and any place it is legal to carry in public or on premises in which possession of a firearm is not illegal (all legal weapons covered). All family members that reside at the home of the Primary member, who are not prohibited from possessing a firearm, shall be covered at no additional cost inside the residence ONLY (all covered up to a 250k bond).
The added Civil Liability Protection Covers a Concealed Carry Permit holder for Civil Damages coverage up to 1 million dollars is included with this plan for the Primary member.
This plan includes access to our 24-hour emergency hotline, attorney fees, investigators fees, experts witnesses, and other expenses associated with defending criminal, civil and administrative actions stemming from a self-defense incident. Appeals and Firearm Replacement during trial Covered. The plan also includes: Up to $250 a day work loss while in criminal or civil trial, up to 10 sessions (up to $4k) for a licensed counselor, up to $3k for crime scene clean-up in home ONLY, if needed, and any other benefits or services that are standard with all plans. The Buyer acknowledges that they are not a prohibited person, and if found that they are a prohibited person and it is against any state or federal law for them to possess a firearm, then their membership is forfeited and will not be refunded.
The Defender Plan will be an annual membership and coverage is good for one year. The Defender Plan is a recurring subscription membership either yearly or monthly payments; and if you choose to pay by check using the mail-in form it should be mailed 5 days prior to your anniversary date. On the next step, you will choose if you want to pay annually or monthly. Monthly memberships agree to pay monthly fees for at least one year to complete annual membership.
Force used against people who are in your house with permission or invite.
Digital Membership Cards - We do not send out plastic cards or packets. You can immediately save your digital membership card to your phone after purchase, or you can print out your membership card to carry in your wallet.
Access to 24- hour Emergency Hotline - Your emergency calls will be answered by a live agent 24-hours a day, 365 days a year. Your call will immediately be patched through to an attorney, and you will have access to immediate legal support.
Access to Online Content and Videos - We provide our members with weekly content that is directly applicable to concealed carry. We only send out 2 newsletters a week, and you must opt in to receive our free newsletters.
Your Email Address Enter your email address to access your membership online.
Your Mobile Number Please provide your mobile number so you can receive notifications regarding your account.
Upload a photo of your permit Maximum upload size 10MB.
Upload Photo Simply click to browse for an existing photo or take a new one. Please select a png or jpg no more than 4MB in size.
I would like to opt-in to receive marketing material from you via e-mail and/or text messages (carrier fees may apply).
By registering you agree to the terms and conditions set forth by CCW Safe. This membership is assigned to the person stated on the front of the card and is non-transferable. We reserve the right to revoke this membership if its privileges are abused.
In the next step you'll choose your plan and add-ons.
Keep up on the latest from CCW Safe.
If you have an emergency please call the hotline number on your card after calling 911.
Copyright © 2018, CCW Safe.


Bayern Munich moves on in the Champions League playoffs by beating Real Madrid in penalty kicks.
Goalies, watch this one, many great saves by both keepers to keep this match exciting to watch.
on and play Chelsea. Bayern Munich vs. Chelsea coming up May 19th, exciting match to watch.
Some Free Books On Soccer, Some From $9 to $47, Great Choices.
Note: If you like this video, click on the tags below, each tag will take you to more videos in that category.


text:
IMPORTANT NOTICE – METFORMIN
Compliance & Ethics Program
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United States Medical Affairs
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Inhalation Research
Microsieve Technology
LIFE AT LUPIN
Why Lupin?
Lupin U.S. Locations
Generics/Products
GENERICS PRODUCTS
Why Lupin Generics?
Lupin currently produces more than 180 affordable generic medications and is the 3rd largest pharmaceutical company in the U.S. in terms of prescriptions dispensed. Lupin's generic business is steadfastly committed to quality and reliability, which ensures the consistent delivery of high-quality products to the market.
ALL A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
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NDC #
RLD / Brand Name
TE Rating
Therapeutic Category
Vyfemla™
0.4mg/0.035mg
Ovcon® 35
Oral Contraceptive
Voriconazole IR Tablets
Vfend®
Voriconazole Oral Suspension
40 mg/mL
49 g (75 mL when reconstituted)
Vancomycin HCl Capsules USP
20 UD
Vancocin®
Valsartan & Hydrochlorothiazide Tablets USP
320mg/25mg
Diovan HCT®
Angiotensin Receptor Blocker w/ Dieretic
320mg/12.5mg
*All registered trademarks are the property of their respective owners. These products are intended for U.S. residents only.
Copyright © 2020, Lupin Pharmaceuticals, Inc., All Rights Reserved.
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Information provided on this site is intended for use only by residents of the United States. The products discussed herein are available only upon prescription from a medical doctor or a qualified medical professional. Consumers should not construe any information herein as medical advice or as a substitute for discussions with a prescribing practitioner or other qualified medical professional. Reader understands and agrees to the foregoing.
Information provided on this site is intended for use only by residents of United States. The products discussed herein are available only upon prescription from a medical doctor or qualified medical professional. Consumers should not construe any information herein as medical advice or as a substitute for discussions with a prescribing practitioner or other qualified medical professional. Reader understand and agrees to the foregoing.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: using wildcard in including script from node_modules I'm using npm and express.js, and would like to manage my front end dependency using npm.
I do this in my app.js
app.use( express.static('./') );
app.use('/scripts', express.static(__dirname + '/node_modules/fabric/dist/'));

so I'm able to use  <script src="/scripts/fabric.js"></script> in my front end.
How do I make it dynamic to all script? like I have jquery I have to do
app.use('/scripts', express.static(__dirname + '/node_modules/jquery/dist/')); ?
I wish I can do this app.use('/scripts', express.static(__dirname + '/node_modules/*/dist/'));

redpajama_set_name: RedPajamaStackExchange


(sen-trip -ă-t'l) See centripetal force.
The radial component of the acceleration of a particle or object moving around a circle, which can be shown to be directed toward the center of the circle. Also known as radial acceleration.
They report that high centripetal accelerations induce large body forces on the high-density cold reactants and hot, low-density products.
It described that the steering was stable, when the centripetal acceleration of the fully loaded train was not more than 0.
Contrarily, for large loading strip lengths, the inertial forces of moving system greatly affect the dynamic behavior of the bridge, especially with the contributions arising from Coriolis acceleration and centripetal acceleration (Table 1); as a consequence, the maximum amplification is observed in the high range of speeds.
Conventional wisdom has it that this centripetal acceleration is not affected by relativity, since it acts in a direction which is normal to the velocity of the object.
Freeze ride, and to measure the centripetal acceleration in the loop on the Flashback.


We're all well versed in the consequences of impaired driving: at worst, killing or injuring ourselves or others; at best, being fined, jailed or having our licences or vehicles seized.
But where's the reward for not driving drunk? For taking a cab, or surrendering one's car keys?
In its latest TV ads, the Nova Scotia Liquor Corporation honours responsible behaviour.
It's an upbeat approach to the usually more sombre and graphic anti-drunk driving public service announcements.
"The holiday season has a huge amount of television messages directed at people and trying to getting through all that in a meaningful and noticeable way is really tough and in our research we found that the standard sort of crash car stuff actually doesn't resonate with people," said Rick Perkins, the liquor corporation's VP, Business Development, Communications and IT.
This is the latest in a series of irreverent ads creative by the liquor corporation's longtime advertising firm Revolve.
Previous installments showcased tongue-in-cheek alternative ways to get home (piggyback, wheelbarrow, donkey) or depicted the grim reaper "killing time" (singing in choirs, playing hockey) because of downtime wrought by responsible drivers.
"It comes from a more intuitive-based and professional understanding that in order to inform people you have to engage them," said Nelson Angel, the agency's president and senior brand strategist.
The company had wranglers steer people leaving Durty Nelly's Irish pub toward real cabbies set up with hidden cameras.
Afterward, Charlottetown resident Judy Macdonald didn't need much convincing to sign the waiver. Just two years ago, the 56-year-old lab technician's only son was fatally struck in a Florida crosswalk.
"It's a wonderful message; if it saves one child's life then it's worth it," she said of her participation in the commercial.


In 1559, Spanish explorer Tristán de Luna led a fleet of ships from Mexico to Pensacola Bay to settle the Florida frontier for the Kingdom of Spain. But a hurricane struck soon after his arrival, destroying the small colony and sinking six of his ships. Few significant remains were uncovered for more than 400 years—until a ship was found underwater off Emanuel Point in modern-day Pensacola.
Florida's Lost Galleon documents the groundbreaking discovery of the earliest shipwreck found in Florida. Underwater archaeologists describe how they explored the ship's hull and recorded it carefully in order to reconstruct the original vessel and its last mission. They take readers into the laboratory, where they explain how the waterlogged objects they uncovered were analyzed and prepared for public display. The story of the ill-fated colony unfolds as they discuss the large amount of surprisingly well-preserved Spanish colonial artifacts, including armor, ammunition, plant and animal remains, and wooden and metal tools.
The excavation of the Emanuel Point shipwreck was driven by the enthusiasm and support of local volunteers, and this volume highlights the importance of such public archaeology projects. Florida's Lost Galleon invites readers to experience the exciting world of marine archaeology as it opens up a forgotten chapter in American history.
Roger C. Smith served as state underwater archaeologist for the Florida Bureau of Archaeological Research for three decades. He is the author of Vanguard of Empire: Ships of Exploration in the Age of Columbus and The Maritime Heritage of the Cayman Islands, coauthor of An Atlas of Maritime Florida, and editor of Submerged History: Underwater Archaeology in Florida.
An engaging and often exciting story. . . . Smith has provided an excellent example of well-managed, long-term investigation, expertly organized and clearly and intelligently presented.


The spectacular nature of Cyprus, however, lies primarily in its beautiful beaches and crystal clear sea. Not everywhere, however, you will find Caribbean beaches. The best area is the south-east coast: from Ayia Thekla and Ayia Napa (the Cypriot Ibiza with nightlife and nonstop entertainment), passing the cape called Cavo Gkreko (natural park), up to the tourist areas of Protaras and Pernera, and finally to Kapparis, on the border with North Cyprus.
Precisely in this area our investment offers are located.


Bryan is a young, well paid, high tech worker from Ottawa. He is looking to start trading stocks but first needs some questions answered.
I have a question for you regarding online brokerage services. I've read your posts about Questrade and how you use them, and I think that I understand the concept. With a $4.95 a month plan, you can purchase 495 shares, after that you pay $0.01 per share?
My question is with dividends, where does the dividend money go to? Back to your questrade account? Or do you get a cheque in the mail?
I'm 27 years old, first time home owner (in about 3 months I close) and make a pretty decent salary in the high tech sector in Ottawa, and would like to start investing some of my extra money in dividend stocks such as BMO and Royal Bank. I was wondering if you could post a really n00b post on how to get started with maybe $1000 (without posting what to buy) but all the sort of beginner questions one would need to know.
The way that Questrade works is that they have a minimum charge of $4.95/trade (<=495 shares), $0.01/share after that for a maximum of $9.95/trade. If you trade 700 shares, you'll be charged $7 for that trade. They call it democratic pricing.
With regards to dividends, they will be deposited as cash back to your account UNLESS you instruct the discount brokerage to reinvest them for you (DRIP). Most brokerages will offer DRIP for free, however, the condition is that the dividend paid out must be enough to purchase 1 share, or else it will just sit in your account as cash.
For example, CIBC's dividend yield is currently around 5.35% (@$65), which means that you'll need to own approximately $4,860 (current price/yield*4) worth in order to receive enough in dividends / quarter to purchase 1 share at today's price.
That brings me to the last point, if you want to buy individual stocks, $1,000 isn't enough. It might be enough for a small position in 1 stock, but then where is the diversification? If you want to start with a smaller balance, I would suggest that you invest in low MER index mutual funds which will also allow for small monthly contributions. When you build up your mutual fund account, you can then consider switching the money out into a self directed account.
Assuming Bryan has started an RRSP (he should, since he's making a pretty decent salary), I think FT's advice is spot on that he buy low MER index funds (TD efunds are the favourites for many of us) to diversify.
If, on the other hand, Bryan is already funneling a good amount to his RRSPs, then buying a dividend stock or two, unregistered, with $1k isn't such a bad idea as, ideally, his registered portofolio should be well diversified and generally much larger than the unregistered.
Dividend investing is a great thing, however, for mid-to-high salary earners, diversified investing including dividends AND growth, within an RRSP is really the way to go.
If Bryan has left over cash after paying the mortgage and maxing out his RRSP then he should go ahead and buy his favourite dividend stock or two, otherwise, he's probably best off to stick with index funds within an RRSP for now and worry about dividend investing when the cash flow improves or the RRSP fund is in pretty good shape.
I think that the first thing to do is save in a tax-efficient retirement account.
In addition, unless your portfolio is more than $15,000, I wouldn't go into individual stocks. I would go into individual stocks if I had the time to invest in researching them.
Otherwise if you either have the money but have no time or you have the time but low amounts of money I would simply purchase several index funds and keep my contributions flowing each and every month.
Also how do you get your money out of the brokerage account if you want to take some profit and go on a shopping spree?
Rod, it's pretty easy to withdraw money from a brokerage account. All that's required is that you have cash available in the account, then do a an electronic transfer from the brokerage to your bank account.
I suggest trying out Questrade with $100 first before you start pouring in real money. My personal experience with it has been bad, but individuals might have different preferences.
Anyways, there is a 100 different ways to invest your money, first thing he needs to do is to access his risk tolerance and come up with his own strategy. As I am about the same age as Bryan and I feel confident in my strategy I have no worries buying one stock at a time.
Bryan should check to see if his employer will match his RRSP contributions up to a certain level as several high-tech companies in Ottawa offer this benefit. If so, he should first ensure that he maximizes this source of free money before considering other options.
Bryan should contribute the maximum to his RRSP, then use his tax refund to pay down his mortgage. This way he will build up equity in the home which can be borrowed against for investing in the future. Assuming a well diversified RRSP , he will have a good start to securing his future. He should note that a home (primary residence) is a major investment that can appreciate over time with no capital gains. Interest paid on investment loans can be deductible if there is reasonable expectations of dividends being paid. Interest will not be deductible if the stocks purchased are speculative, and you are looking for capital gains only.
Investing is like a gamble specially on stock market. ALways check the stock market report.
Quick Question outside of the stock market talk!
Im new to investing and have been primarily doing so in Registered MF's and taking advantage of the tax break – I've been using ING Direct and have been self picking MF's – Using a website such as morningstar, How to I figure out the dividend distribution for any given MF.
Which of the Investment Style Factors do I look at?


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Lobsang Rampa
Notable Works »
Page views of Lobsang Rampas by language »
Among WRITERS »
In United Kingdom »
Among WRITERS In United Kingdom »
Lobsang Rampa was the pen name of Cyril Henry Hoskin (8 April 1910 – 25 January 1981), an author who wrote books with paranormal and occult themes. His best known work is The Third Eye, published in Britain in 1956. Following the publication of the book, newspapers reported that Rampa had been born Cyril Henry Hoskin, and was a plumber from Plympton in Devon who claimed that his body hosted the spirit of a Tibetan lama going by the name of Tuesday Lobsang Rampa, who is purported to have authored the books. Read more on Wikipedia
Since 2007, the English Wikipedia page of Lobsang Rampa has received more than 439,492 page views. His biography is available in 21 different languages on Wikipedia (up from 20 in 2019). Lobsang Rampa is the 1,129th most popular writer (down from 1,094th in 2019), the 904th most popular biography from United Kingdom (down from 854th in 2019) and the 109th most popular British Writer.
Lobsang Rampa is most famous for being the birthplace of the Dalai Lama, but it is also a sacred place for Tibetan Buddhists.
Page views of Lobsang Rampas by language
Among WRITERS
Among writers, Lobsang Rampa ranks 1,129 out of 5,755. Before him are Meng Haoran, Joan Fuster, Gaius Asinius Pollio, Assia Djebar, James Bond, and Hrotsvitha. After him are Ken Kesey, Eiji Yoshikawa, Grand Duke Konstantin Konstantinovich of Russia, Joachim du Bellay, Rigas Feraios, and Polyaenus.
Most Popular Writers in Wikipedia
Meng Haoran
Joan Fuster
Gaius Asinius Pollio
Assia Djebar
Hrotsvitha
Grand Duke Konstantin Konstantinovich of Russia
Joachim du Bellay
Rigas Feraios
Polyaenus
Among people born in 1910, Lobsang Rampa ranks 49. Before him are Galina Ulanova, Meša Selimović, Edvard Kardelj, Princess María de las Mercedes of Bourbon-Two Sicilies, Archer Martin, and Eero Saarinen. After him are John Sturges, Shunichi Kumai, Miguel Najdorf, Dorothy Vaughan, Imi Lichtenfeld, and Tjalling Koopmans. Among people deceased in 1981, Lobsang Rampa ranks 40. Before him are Zarah Leander, Princess Margarita of Greece and Denmark, Harry Harlow, Will Durant, Bill Haley, and Bernard Lee. After him are Leo Kanner, Omar Torrijos, Lotte Lenya, Prince Yasuhiko Asaka, Duško Popov, and Stefan Wyszyński.
Galina Ulanova
Meša Selimović
Edvard Kardelj
Princess María de las Mercedes of Bourbon-Two Sicilies
Archer Martin
Shunichi Kumai
Miguel Najdorf
Dorothy Vaughan
Imi Lichtenfeld
Tjalling Koopmans
Others Deceased in 1981
Zarah Leander
Princess Margarita of Greece and Denmark
Harry Harlow
Omar Torrijos
Lotte Lenya
Prince Yasuhiko Asaka
Duško Popov
Stefan Wyszyński
In United Kingdom
Among people born in United Kingdom, Lobsang Rampa ranks 904 out of 7,765. Before him are Henry Tingle Wilde (1872), Keith Moon (1946), Noah Jupe (2005), Kristin Scott Thomas (1960), Pete Postlethwaite (1946), and Infante Alfonso Carlos, Duke of San Jaime (1849). After him are Joan Collins (1933), Natasha Richardson (1963), Brian Josephson (1940), Samuel Crompton (1753), H. H. Asquith (1852), and Isambard Kingdom Brunel (1806).
Others born in United Kingdom
Henry Tingle Wilde
Pete Postlethwaite
Infante Alfonso Carlos, Duke of San Jaime
Brian Josephson
Samuel Crompton
H. H. Asquith
Isambard Kingdom Brunel
Among WRITERS In United Kingdom
Among writers born in United Kingdom, Lobsang Rampa ranks 109. Before him are W. H. Auden (1907), Rosamunde Pilcher (1924), Patrick White (1912), Allan Pinkerton (1819), Thomas Chatterton (1752), and Elizabeth Gaskell (1810). After him are Dylan Thomas (1914), Arthur Hailey (1920), Thomas De Quincey (1785), John Berger (1926), James Anderson (1680), and P. G. Wodehouse (1881).
British born Writers
Allan Pinkerton
Thomas Chatterton
Arthur Hailey
P. G. Wodehouse
5755 Individuals
5th Dalai Lama
Dalai Lama Of Tibet (1617–1682)
Lobsang Sangay
Sikyong Of The Tibetan Government In Exile
Gyaincain Norbu
11th Panchen Lama According To The Chinese Government


Microbiology Institute of the Federal University of Rio de Janeiro, Brazil.
Fabio was a Fulbright Visiting Scholar at U.C. Berkeley collaborating with Lee Riley on the molecular epidemiology of Staphylococcus aureus.
I am a Professor at Fluminense Federal University in Niterói, RJ, Brazil and my lab conducts molecular epidemiologic studies and experiments to understand the pathogenesis of Gram-positive bacterial isolates.
My work primarily focused on understanding the mechanisms of bacterial persistence within its host. Our work involves understanding the role that the mce operons, encoding ABC like transporters, play in the process of lipid importation and metabolism.
Another project that we are working on involves characterization of the cell wall lipid content of drug resistant Mycobacterium tuberculosis isolates circulating throughout different regions of India. The main objective of this project is to discover novel mechanisms of Mycobacterium tuberculosis drug resistance.
The project I worked on for the past 4 years was focused on drug-resistant GNB on spinach. Sampling from organic and non-organic retail store-bought spinach, we identified saprophytic bacterial species by sequencing the 16srRNA region, tested for antibiotic susceptibility, and screened drug-resistance genes. I found CTX-M-15 genes to be harbored by Pseudomonas putida and Pseudomonas teessidea. This information is of great importance as CTX-M-15 genes have been found globally in Escherichia coli pathogens that cause community-acquired infections. In the past years, I also helped develop a protocol for a collaborative study on bacterial vaginosis with Dr. Purnima Madhivanan and Dr. Jeff Klausner at the San Francisco Department of Public Health. The project consisted of describing the vaginal microbial population, especially Lactobacillus species in pregnant women with and without BV in Mysore, India, and the Bay Area, California.
Before coming to the IDI PhD program I got my MPH in Epidemiology/Biostatistics from the Berkeley School of Public Health. During my MPH I worked in the Riley lab on a molecular epidemiology project investigating the distribution of super antigen genes in Group A Streptococcus collected in Brazil. I am currently investigating antibiotic resistance in gram negative bacteria. I am using a functional screen of a metagenomic library generated from microbial communities found on retail "baby spinach" to identify novel antibiotic resistance genes. We are also investigating the spread of known antibiotic resistance genes in microbial communities from food products.
Tuberculosis (TB) faces difficult challenges for its treatment and control. Both the diagnosis of TB and Mycobacterium tuberculosis drug susceptibility testing take weeks and clinicians often do not know if the patient is taking an appropriate set of drugs until complications or even death occur. Consequently, early determination of a successful drug therapy response in individuals infected with M. tuberculosis is urgently needed. Since theM. tuberculosis cell wall is comprised of a diverse repertoire of lipids, I am interested in the role of these lipids as antigens for serologic response during M. tuberculosis infection. My dissertation research focused on the examination of lipid-antibody response as a potential biomarker used to monitor treatment response in M. tuberculosis infected hosts.
Charlotte Smith received her PhD from the University of California, Berkeley's School of Public Health - Environmental Health Sciences Division. She studies survival or pathogenic bacteria in free-living protozoa in drinking water.
My name is Michael Picetti and I am a second-year MPH student working on a project involving antimicrobial resistance prevalence among E. coli that cause urinary tract infections in Mysore, India. Specifically, I am running PCR to check for the presence/absence of particular genes (ndm-1, CTX-M, KPC, and ESBL-multiplex) that confer antimicrobial resistance in these uropathogenic E. coli. Also, I am identifying the various clonal groups to which these uropathogenic isolates belong by performing DNA sequencing. Our hypothesis is that the presence of only a few clonal groups would represent an endemic pattern of occurrence of these uropathogenic isolates whereas a large number of clonal groups would suggest an epidemic pattern of occurrence. Determining the pattern of occurrence is important in potentially disrupting the further dissemination of such multi-drug resistant E. coli strains in India and beyond.
I have been conducting my master's degree at the Federal University of Rio Grande do Sul (UFRGS), Brazil, in the Molecular and Cellular Biology Program since 2011, where I am involved in immunology and molecular biology research. I received my undergraduate degree in biomedicine from Methodist University Center (IPA), analyzing gene expression in humans infected with Mycobacterium tuberculosis. I came to the Riley lab to work on a project titled "Human gene expression profile to identify biomarkers for active TB" that I began at the Center for Scientific and Technological Development (CDCT), my laboratory in Brazil.
During my phD, we have been collaborating with the Riley lab, using several sequencing-based typing methods to generate definitive, library typing information, about Acinetobacter strains from patients at a public university-affiliated hospital in the city of Rio de Janeiro, Brazil. Information from this study described the international spread of Acinetobacter baumannii clones in Rio de Janeiro. Acinetobacter is an important pathogen associated with healthcare-acquired infections (HAI) and a cause of considerable morbidity and mortality. International A. baumannii strains that possess high levels of resistance to all main antimicrobial agents are widespread in Rio de Janeiro, Brazil. Based on this information, we also developed a PCR-typing method to quickly identify the dissemination of the main clones in the Brazilian hospitals. As the A. baumannii and A. nosocomialis isolates were multidrug-resistant (MDR), we also typed and investigated the gene cassettes within the integrons.
As a post-doctoral researcher now based in Rio de Janeiro, Brazil, I am going to continue to work with MDR Acinetobacter baumannii isolates focusing on the relationship between virulence and colistin resistance. The strategies used are going to be whole-genome sequencing and animal assays to more thoroughly understand this interaction within and among the organism's international clones prevalent in Rio de Janeiro.
Project: Urinary tract infection, Molecular epidemiology of Staphylococcus saprophyticus isolates in Rio de Janeiro, Brazil.
Description: Staphylococcus saprophyticus is the second most frequently associated agent with community urinary tract infections in young and sexually active women. Work proposal: molecular characterization and investigation of clones disseminated in the community by PFGE, determination of antimicrobial susceptibility and characterization of resistance genes in Staphylococcus saprophyticus isolated from women with community urinary tract infection or colonized by this microorganism.
Biologist. PhD student at Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Doenças Infecciosas e Parasitárias –DIP, Rio de Janeiro, Brasil. (Medical School, Infectious and Parasitic Diseases, Rio de Janeiro, Brazil).
I arrived in Lee's laboratory as a Visiting Scholar in early 2011. The main objective of my project was to construct and characterize defined mutant strains of M. tuberculosis with gene replacement (allelic exchange) to study the importance of the iunH gene in M. tuberculosis biology.


text:
Giovanni Domenico (Giandomenico) TIEPOLO
1727-1804 - Painter and etching printmaker in Venezia
To associate the name "Tiepolo" to Carnival imagery, it means we're talking about Giandomenico Tiepolo, the more widely known of the family, in all senses.
Giandomenico Tiepolo came from an artist family, his father - Giovanni Battista Tiepolo (1696-1770) - was a well known and recognized fresco painter and did quite high quality works:
Würzburg (Bavaria): decorating the famous stairwell fresco (1751-1753)
Vicenza: the Villa Valmarana "Ai Nani" (1757)
Madrid: at the palace of Charles III (1762–70)
Most of these works were done having his sons Giandomenico and Lorenzo as assistants, and learning the trade.
Lorenzo was good too, but Giandomenico Tiepolo is the one being more reknown and with more bonds to the Carnival.
By the age of 13 he was his father's main assistant, and around the age of 20 he started doing work on commission on his own.
Giovanni Domenico assisted his father in his work until his father's death in 1770, and he then returned to Venice and started to work on his own projects for real, developing his personal style.
Besides his frescoes work and the oil paintings, what is really special about Giandomenico are his drawings.
Lorenzo Baldissera TIEPOLO
1736-1776 - Painter in Venezia e Madrid
We only know about him that in 1750, went to Würzburg with his father and brother, Giovanni Domenico, where he worked with them on the decorative fresco cycle in the Würzburg Residence.
He went back to Venice, but after 5 years only, Lorenzo left Venice forever and established his life in Madrid (ES) where in later years he got a small yearly pension from the Spanish Royal Family, on which he lived.
Lorenzo died quite young, though, with 40 years only.


A beachfront property on Southampton's Gin Lane will hit the market for the first time in more than 50 years with an asking price of $50 million.
The 4-acre parcel is next door to Wooldon Manor, which Scott A. Bommer, founder of hedge fund SAB Capital, bought for $75 million and then almost immediately sold for more than $80 million, the Wall Street Journal reported. Tim Davis of Corcoran Group, who handled the sale for Bommer, will also represent the owner of the property, William G. McKnight, according to the newspaper.


text:
A Spool of Blue Thread
It was a beautiful, breezy, yellow-and-green afternoon. . .
This is how Abby Whitshank always begins the story of how she fell in love with Red that day in July 1959. The Whitshanks are one of those families that radiate togetherness: an indefinable, enviable kind of specialness. But they are also like all families, in that the stories they tell themselves reveal only part of the picture.
Abby and Red and their four grown children have accumulated not only tender moments, laughter, and celebrations, but also jealousies, disappointments, and carefully guarded secrets. From Red's father and mother, newly arrived in Baltimore in the 1920s, to Abby and Red's grandchildren carrying the family legacy boisterously into the twenty-first century, here are four generations of Whitshanks, their lives unfolding in and around the sprawling, lovingly worn Baltimore house that has always been their anchor.
Brimming with all the insight, humor, and generosity of spirit that are the hallmarks of Anne Tyler's work, A Spool of Blue Thread tells a poignant yet unsentimental story in praise of family in all its emotional complexity. It is a novel to cherish. (From the publisher.)
1. What are the main themes of the novel? Which did you find most thought-provoking?
2. The novel opens and closes with Denny. Do you think he's the main character? If not, who is?
3. We don't learn the full significance of the title until nearly (on page 350). How did this delay make the metaphor more powerful? What is the metaphor?
4. On page 10, Tyler writes, "Well, of course they did hear from him again. The Whitshanks weren't a melodramaticfamily." What type of family are they? Compare the way you see them with the way they see themselves.
5. Chapter 2 begins with the Whitshank family stories: "These stories were viewed as quintessential—as defining, in some way—and every family member, including Stem's three-year-old, had heard them told and retold and embroidered and conjectured upon any number of times." (page 40) Why are these two stories so important? Why is the story of Red's sister important to Red's family?
6. "Patience, in fact, was what the Whitshanks imagined to be the theme of their two stories—patiently lying in wait for what they believed should come to them." (page 57) Others might say it was envy or disappointment. Which interpretation makes the most sense to you? Can you think of another linking theme?
7. How does Abby's story about the day she fell in love with Red fit into the Whitshank family history? Why isn't it one of the family's two defining stories?
8. Much is made of Abby's "orphans," which we learn also include Stem. What does her welcoming of strangers into her home say about her character? How do the others' responses set up a subtle contrast?
9. Discuss the character Denny. Why is he so resentful of Stem? Why is he so secretive about his life?
10. Do Red and Abby have favorite children and grandchildren? Who do you think each one favors?
11. On page 151, Tyler writes about Abby: "She had always assumed that when she was old, she would have total confidence, finally. But look at her: still uncertain." Do you think Abby's family sees her as uncertain or lacking in confidence? Why?
12. Abby dies suddenly in an accident, just like Red's parents did. When it came to his parents, "Red was of the opinion that instantaneous death was a mercy…" (page 153) Do you think he felt the same way after Abby's death?
13. Why didn't Abby tell Red about Stem's mother? Why didn't Denny tell Stem? And why, after they learn the truth, does Stem make Red and Denny promise not to tell anyone else?
14. At Abby's funeral, Reverend Alban speculates that heaven may be "a vast consciousness that the dead return to," bringing their memories with them. (page 189) What do you think of his theory? What do you imagine Abby would say about it?
15. Why did Red's pausing to count the rings on the felled poplar make Abby fall in love with him?
16. The novel isn't structured chronologically. How does Tyler use shifts in time to reveal character and change the reader's perception?
17. What is the significance of the porch swing? What does it tell us about Linnie Mae and Junior?
18. After reading their story, how did your opinion of Linnie Mae change?
19. The Whitshank house, built by Junior and maintained by Red, is practically a character in the novel. What does it mean to the Whitshank family? Why, in the end, does it seem easy for Red to leave?
20. On the train at the end of the novel, Denny sits next to a teenage boy who cries quietly. What is the significance of this scene?
(Questions issued by the publisher.)


text:
Beat the freeze: Dropping temps could mean damaged devices
UScellular offers five tips for protecting smart devices in extreme winter weather
This winter could be colder and snowier than normal, according to the U.S. Winter Outlook released by the National Oceanic and Atmospheric Administration (NOAA). While winter safety is top of mind for families, pets and homes, smart devices should not be overlooked. It is important to keep devices protected from extreme weather to ensure that safety features like navigation, storm tracking and emergency notifications are available when needed.
Lithium-ion batteries, used in smartphones and other connected devices, are liquid and cold temperatures cause the molecules to shrink. This can slow down how the device operates and could lead to LCD screens dimming, loss of button functionality and shorter battery life.
"When temperatures drop below freezing, it's time to consider how we are using and storing devices," said Thomas White, director of sales for East Tennessee at UScellular. "It's important to add additional layers around our phones to protect them against the shock of cold temps."
UScellular offers its annual tips to help keep devices safe this winter.
Power up devices. If the forecast includes freezing temperatures, be sure to keep your phones fully charged since battery life drains at a faster rate in cold temps. Portable chargers can come in handy if an outlet or charging pad isn't available.
Layers are best. Using a case at all times is the best way to protect devices from damage, but during cold weather it adds another layer of protection. An insulated case provides an additional barrier to the elements and delays loss of functionality.
Use body heat. Keeping devices close to your body will be a natural source of warmth. Since the body's natural temperature is around 98 degrees, placing a phone closer to your body – such as in a pocket – will help regulate its temperature and protect it from extreme cold.
Wait before using again. If the phone gets too cold, it may shut off to protect itself. When that happens, be sure to let the phone warm up before trying to use it again. Do not use blow dryers, ovens, space heaters or other heating devices to warm devices as this could cause permanent damage.
Take extra precautions. Minimize the amount of time that a device is exposed to the cold, so try to not leave it in your empty car for a long period of time, and if you must use it while outside, ensure that it's shielded from the wind and tucked close to the body when viewing.
About UScellular
UScellular is the fourth-largest full-service wireless carrier in the United States, providing national network coverage and industry-leading innovations designed to help customers stay connected to the things that matter most. The Chicago-based carrier provides a strong, reliable network supported by the latest technology and offers a wide range of communication services that enhance consumers' lives, increase the competitiveness of local businesses and improve the efficiency of government operations. Through its After School Access Project, the company has pledged to provide hotspots and service to help up to 50,000 youth connect to reliable internet. Additionally, UScellular has price protected all of its plans, promising not to increase prices through at least the end of 2023. To learn more about UScellular, visit one of its retail stores or www.uscellular.com. To get the latest news, visit newsroom.uscellular.com.
Christy Rowe
Latest posts by Christy Rowe (see all)
Beat the freeze: Dropping temps could mean damaged devices - January 23, 2023
UScellular kicks off eighth annual Black History Month Art Contest with Boys & Girls Clubs of the Tennessee Valley - January 19, 2023
UScellular offers tips to help prevent distracted driving among teens - January 5, 2023


text:
Termites At The Statue Of Liberty
Chuck Woods (352) 392-1773 x 281
Nan-Yao Su (954) 475-8990
Al Farrugio (212) 363-6604
Mark Gilberg (318) 357-6421
NEW YORK — Give me your tired, your poor, your huddled masses yearning to breathe free. OK, but nobody said anything about termites.
For the past three years, termites in the Statue of Liberty National Monument have been a growing source of concern for the National Park Service. In fact, flying termites were so troublesome in April 1996 that Lady Liberty's museum area was temporarily closed to visitors.
Now, with the help of a University of Florida scientist who has developed new environmentally friendly measures to stop the pest, termites have stopped swarming at the nation's most famous national monument and will be completely under control by this summer.
"This is the first time in more than 100 years that there has been any problem with native subterranean termites on Liberty Island," said Nan-Yao Su, professor of entomology and an internationally recognized termite expert with UF's Institute of Food and Agricultural Sciences.
"I suspect termites found their way to the island when the statue was being restored for the 1986 Centennial celebration. They probably hitchhiked in with landscaping plants and wood construction materials."
He said the most severe infestations have been in the pedestal or base of the monument that houses the museum and utility rooms.
"We had some serious termite infestations in the museum's wooden display cases that contained valuable artifacts and historical documents, but none of these national treasures were damaged," Su said. "At no time did the termites pose any threat to the structural integrity of the monument– they were not about to topple Lady Liberty."
Al Farrugio, horticulturist at the statue, said the park service first noticed termites swarming in 1994 and asked Su to begin working on the problem. His work at the statue is supported by a grant from the park service's National Center for Preservation Technology and Training, based in Natchitoches, La.
"The new control system eliminates the need for injecting pesticides into the soil that could leach into the harbor. It's also well suited to sensitive historical sites like the Statue of Liberty," Farrugio said.
Su said the key to success in controlling subterranean termites is getting the pesticide down into their underground colonies around the base of the monument. Unless the underground termite colony itself is destroyed, the pest will continue to build tunnels into the monument looking for wood.
"Termites are very picky about what they will eat and bring back to their underground colonies," he explained. "They will literally seal off their nest from anything they don't like.
"After testing many different chemicals, we found they will feed on hexaflumuron, a chemical which makes them unable to molt or reproduce. It eventually kills the entire underground colony," he said.
Su developed a simple termite monitoring and baiting system that uses pesticide only when termite activity has been detected. Monitoring devices, placed in the ground around the statue, each contain pieces of wood. When termites begin feeding on the wood, it is removed and replaced with the hexaflumuron bait that slowly kills off the entire underground colony. Once the colony has been eliminated, the system remains in place to detect any future termite activity.
To control termites munching on the wooden display cases in the museum, he developed an above ground feeding station that delivers the bait on-site immediately.
"Around the monument, we've had our baiting system in the ground now for about eight months and we have not seen any flying termites in the statue this year. We got through April without any termite swarming, which is a good sign," Su said. "We are keeping a close watch on the situation with the termite monitoring system and we won't declare victory until Liberty Island is completely free of termites."
Mark Gilberg, research coordinator of the park service's preservation technology and training program, said Su's termite control system also is being used to protect other historic landmarks, including the Cabildo and the Presbytere in New Orleans' French Quarter.
"The technology is ideal for protecting historic properties because you don't have to drill holes through floors, walls or any other fabric of the structure to introduce insecticides," he said.
Gilberg said regular pesticide sprays didn't stop the very destructive Formosan termite in the historic French Quarter buildings, but the control system has brought the pest under control for the first time by destroying its underground colonies.
The Formosan termite is a very aggressive species of the subterranean termite, and it is slowly spreading in the warm, humid climate of the southeast United States. Unlike the native subterranean termite, which has been found as far north as Toronto, the Formosan termite prefers warmer climates where colony populations average several million.
The termite control system is patented by UF and licensed exclusively to DowElanco of Indianapolis. It is marketed to consumers as the Sentricon Termite Colony Elimination System.
-30-TELEVISION VIDEO AVAILABLE–PLEASE CONTACT FRANK AHERN (352) 392-9092
← Grasshopper Gets Gator Nickname From UF Entomologists
Strange Bedfellows: Warm Weather Means Dust Mite Population Explosion →


text:
Q: How to import API route in NextJS for getStaticProps? I am using NextJS's getStaticProps to fetch some data from an external API. Reading the data fetching documentation on getStaticProps I came across this particular note:

Note: You should not use fetch() to call an API route in your
application. Instead, directly import the API route and call its
function yourself. You may need to slightly refactor your code for
this approach.

Right now I am calling getStaticProps directly from a page component called Index as follows:
export default function Index({ data }) {
  return
{data}
;
}

export async function getStaticProps() {
  const response = await fetch("http://127.0.0.1:8000/data");
  const data = await response.json();
  return { props: { data } };
}

As per the above documentation, this should not be done. How can I restructure my code to fetch data correctly? What does it mean to "import the API route and call its function yourself?"

A: I think that the Note is related to internal api path

You should not use fetch() to call an API route in your application

I suppose is related to every path that you define in /pages/api/*. Instead of fetch you can simply refactor your code and import data.
So, the code below is correct, don't need any refactoring
export default function Index({ data }) {
  return
{data}
;
}

export async function getStaticProps() {
  const response = await fetch("http://127.0.0.1:8000/data");
  const data = await response.json();
  return { props: { data } };
}


Inside the realm of casinos and resorts, few companies have sought to satisfy the sector's appetite for customer loyalty programs as aggressively as House Advantage, a Las Vegas based firm that surged into the ranks of middle market companies as it adroitly served some of the realm's largest enterprise players.
Central to House Advantage's success was the notion that when it came to customer relationships – companies must encourage and bolster those behaviors that grow the long term value of a customer. Along the way – new technologies allowed gaming outfits to more closely track the very behaviors – House Advantage was introducing strategies to incent and manage.
"Technology has taken the leading role. It has allowed companies to collect data, but it has also given them the ability to actually speak to the customer. And today the customer expects to be spoken to on an individual level," explains Jon Wolfe, CEO, House Advantage. Says Wolfe: "The message has gotten to where it has been individually tailored to each customer, their wants, their needs and their interests." Join us when Jon shares the business building journey that led him to the intersection of new data technologies and customer relationship building.
Sweeney, Jack. "247: Helping the House Win | Jon Wolfe, CEO, House Advantage". Middle Market Executive, 30 Jan. 2019.


text:
Michael Peter Ancher (ur. 9 czerwca 1849 w Rutsker na Bornholmie, zm. 19 września 1927 w Skagen) – duński malarz realizmu, znany z przedstawiania pracy rybaków i lokalnych pejzaży.

Życiorys
Michael Peter Ancher urodził się w Rutsker na duńskiej wyspie Bronholm. Był synem lokalnego kupca. Uczęszczał do szkoły w Rønne, jednak nie był w stanie ukończyć szkoły średniej z powodu kłopotów finansowych jego ojca. W 1865 roku podjął pracę w urzędzie w miejscowości Kalø Manor, nieopodal Rønne we wschodniej Jutlandii.

Rok później Ancher poznał malarzy Theodora Philipsena i Vilhelma Grotha, przebywających akurat w okolicach Kalø Manor. Artyści będący pod wrażeniem jego twórczości, zachęcili Michaela do zajęcia się malarstwem w ramach zawodu. W 1871 roku zasięgnął porady historyka sztuki Juliusa Langego w sprawie wymagań Królewskiej Duńskiej Akademii Sztuki w Kopenhadze. Pomimo spędzenia kilku lat tam, opuścił akademię w 1875 roku bez jej ukończenia. W 1874 roku przyjął zaproszenie poznanego w czasie studiów Karla Madsena i odwiedził po raz pierwszy Skagen, który później stał się ważnym miejscem dla artysty.

Po opuszczeniu Kopenhagi Ancher coraz częściej bywał w Skagen, gdzie zafascynowała go praca i życie lokalnych rybaków. W 1877 roku otrzymał Nagrodę Neuhausen za jeden z obrazów. W 1880 roku jedno z jego dzieł, za pośrednictwem duńskiej Galerii Narodowej, zostało przekazane królowi Danii – Chrystianowi XI.

Około lat 80. XIX wieku Skagen stało się popularnym miejscem wśród wielu artystów skandynawskich. Archer łączył styl lokalnych artystów wraz z tym czego nauczył się w akademii. Przy przedstawianiu życia rybaków w Skagen używał naturalnego światła oraz przykładał uwagę do dobieranych kolorów.

W 1880 roku poślubił swoją przyjaciółkę, również malarkę, Annę Brondum. W 1883 roku narodziło się ich jedyne dziecko, córka Helga Ancher. W 1964 roku ich dom został przekazany przez Helgę, w ramach jej testamentu i trzy lata później utworzono muzeum Anchers Hus.

Michael Peter Ancher zmarł 19 września 1927 roku w Skagen w wieku 78 lat. Anna Ancher zmarła 15 kwietnia 1935 roku w wieku 76 lat.

Galeria

Przypisy

Urodzeni w 1849
Zmarli w 1927
Duńscy malarze

redpajama_set_name: RedPajamaWikipedia


text:
Ti=Article 71 - Reports

1.sec=The {_Board} shall draw up an annual report regarding the protection of {_natural_persons} with regard to {_processing} in the Union and, where relevant, in third countries and {_international_organisations}. The report shall be made public and be transmitted to the European Parliament, to the Council and to the Commission.

2.sec=The annual report shall include a review of the practical application of the guidelines, recommendations and best practices referred to in point (l) of Article 70(1) as well as of the binding decisions referred to in Article 65.

=[G/Z/ol/s2]

redpajama_set_name: RedPajamaGithub


Brain cancer cells are particularly resistant to chemotherapy — toxins enter the cells, but before the toxins can kill, cancer cells quickly pump them back outside. In fact, brain cancer cells are even better than healthy cells at cleaning themselves. This means that when hit with chemotherapy, healthy cells tend to die before brain cancer cells. Especially in the brain, killing healthy cells is bad.
Researchers at the University of Colorado Cancer Center have discovered a way to turn off the pumps — only in brain cancer cells and not in their healthy neighbors. Promising early testing provides hope for the nearly 45,000 people diagnosed with brain cancer in the United States every year, who are currently expected to survive less than 12 months after diagnosis.
The idea is this: stop a cell's ability to make GSH and you stop its ability to detoxify — thus sensitizing the cell to even a low dose of chemotherapy. It's tricky to target GSH directly, but clinical trials are already underway for a drug that breaks a link in the chain that leads to GSH. The link is an enzyme called glutamate cysteine ligase (GCL), which cells need in order to make GSH.
So here is the trick and the promise. "If we can selectively keep brain tumor cells from making GSH we can sensitize these tumors to chemotherapy, which may allow doctors to kill more tumor cells with a safe dose of chemotherapeutics," says Christopher Franklin, PhD, investigator at the CU Cancer Center and assistant professor of molecular toxicology at the Skaggs School of Pharmacy and Pharmaceutical Sciences.
Franklin is working with Philip Reigan, PhD, investigator at the CU Cancer Center and assistant professor of medicinal chemistry at the Skaggs School of Pharmacy and Pharmaceutical Sciences to do just that — targeting cancer cells' GSH while leaving the pathway unharmed in healthy cells.
To do it, they're using an exciting class of medicines called prodrugs. By itself a prodrug doesn't do anything — it floats harmlessly through the body. Only, when it comes in contact with another target chemical the prodrug releases a little payload.


There are a total number of 08 trains from Coimbatore or Podanur to Bangalore City. Coimbatore or Podanur is a major link to reach Kerala and other places in Tamil Nadu. This is a transit point for people travelling to Ooty . These trains either stop at Bangalore City or Yeshwantpur railway stations.
These trains become very useful for passengers from Coimbatore or Podanur and nearby places traveling to Bangalore and near by places. Almost all these trains reaches to any of the Bangalore City or Yeshwantpur railway stations.
The list of the trains is given below with their time starting time at Coimbatore or Podanur and arrival time at Bangalore or Yeshwantpur.


Can be programmed for any required output power, can also be programmed to work with a very wide variety of speaker impedance combinaitons.
Available with 2,4 or 8 optional programmable switched outputs.
Compatible with all Eurosmart handsets and dash mount controllers, can also be controlled and operated using the programmable inputs that are included as standard.
Haztec.uk uses 128bit encryption, for secure payments - Powered by Protx.


text:
Christ Our Redeemer
"Proclaim the Love of Christ"
Middle School - Confirmation
Confirmation Blog
Outside Organizations
Church Guidelines
High School Youth Group, you really need to check this out! Every Sunday after Church from 11:45 a.m. till 1:45 p.m. Meet us in the Youth Room. All High School and Middle School Students are welcome and lunch is always provided.
Contact person: Steven Helm vanhelm@msn.com
High School Sunday School in the Youth Room from 9:15 a.m. till 10:15 a.m.
Youth Group in the Youth Room from 11:45 a.m. till 1:45 p.m.
Yearly Activities
Rock the Universe
Summer Retreat
Camping Trip
And much more. Check our Calendar and find us on Facebook at Christ Our Redeemer High School Youth Group (or click the Facebook icon below).
Coming in 2021 - ELCA Youth Gathering in Minneapolis!
The ELCA Youth Gathering for high school-age youth takes place every three years and is about faith formation, worship, study, fellowship, service and play. It is an opportunity for youth to engage with peers from across the United States and the world who share a common commitment and faith in Christ.
Update regarding the 2021 ELCA Youth Gathering (July 22, 2020)- POSTPONED
https://www.elca.org/YouthGathering/COVID19
Click picture for more information!
© Copyright 2015 | Christ Our Redeemer Lutheran Church | 304 Druid Hills Road, Temple Terrace, FL 33617 | (813) 988-4025 | church@corlutheran.org


text:
Autism Community Trust
THE ACT CENTER
JULIE OSTROVSKY
Julie is the Director of Autism Community Trust. She has played an important role in Las Vegas autism community. Julie serves on the Nevada Commission on Autism Spectrum Disorders, is on the board of Friendship Circle and has served on the board of FEAT of Southern Nevada, raising money for services for children and families affected by Autism and related disorders. She has been the voice of reason throughout this project.
Throughout this process Julie has been working on the marketing and public relations efforts that were needed to bring this project into the public eye. Her efforts will result in the success of this mission, to raise money to assist many of our service charities that take care of our Autism Community.
Like many mothers of a child with autism, she manages the impossible, a career, husband, two children, three horses, two dogs Julie finds the time to help our community become a better place to live and socialize.
RICHARD FEMENELLA
Richard has 40 years of restaurant and hotel experience and is one of the founding team members of the Charlie Palmer Group which began in 1997.
On a personal note, Richard is very active in the Las Vegas community. Father of a 20-year-old son severely affected by Autism, Joey and his wife Maureen are his top priority. He has had an 18-year journey in our community, bringing help and services to those families in need. A major supporter of Families for Effective Autism Treatment of Southern Nevada as well as president of his own foundation with partner Julie Ostrovsky, Autism Community Trust. He was a member of the advisory board for the Downtown Las Vegas Redevelopment Board for 10 years. A Past Restaurateur of the year from the Nevada Restaurant Association, today he is a member of the Forbes Financial Council which he has been published by and continually lectures for the Hospitality Program at the Community College of Southern Nevada. He plans to remain an active member of the Las Vegas community for the rest of his life.


text:
Posts by craigm
Hard News: Dressing for the Road, 15:58 Apr 23, 2013
I ride most days for commuting - about 9kms each way. Taupo to Wairakei. I have the luxury of either Mtn bike track or main road (SH1 - but with nice wide shoulders for most of it.) I ride a road bike with clipless pedals (or mtn bike with spd's) and usually take a change of clothes in my bag, along with lunch etc. luckily dress code at work is jeans / tee shirt, so no worries with wardrobe issues.
Used to be totally lyrca for shorts, but this summer have been wearing some groundeffect baggy shorts. Totally fine for the 9k and a bit more stylish if you want to stop off in town for something on the way home.
We have a shower at work, so i just wear a sports tee shirt in summer or in winter it's lyrca cycle shorts with groundeffect daddy long legs tights over the top. then a merino top (or 2 if it's real cold). Then over that a groundeffect Flash Gordon jacket. Just got my 2nd one of those after wearing my previous one for 10 years! Then if it's super cold a full face ski mask. It can get to -4C in winter here so full cover is totally necessary.
Gloves, always. In summer fingerless gloves, in winter full finger gloves. These are my favourite, ninja ice gloves http://www.argus.co.nz/mainmenu99/cat113/Freezer+Gloves/p767/Ninja+Ice+Gloves.html.
Lights, just got one of these for winter. super cool!
http://www.youtube.com/watch?v=ix2sNGhXJ2c
Helmet, always.
Taupo • Since Nov 2007 • 16 posts Report Reply
Hard News: Cheer Germ, in reply to Sacha, 15:17 Jun 3, 2011
except for the times when he didn't quite make it…..<wince>
Hard News: Again: Is everyone okay?, 10:27 Feb 26, 2011
where he said that earthquakes were most likely to happen at the full moon, and the new moon, and two weeks either side. And I guess he's right, technically
2 weeks either side of a full or new moon covers the entire month! So basically he "predicts" an earthquake for any day of the year!
Hard News: RT: Eyjafjallajokull, 19:55 Apr 19, 2010
I've been lucky enough to visit Eyjafjallajokull in 2008, my personal pronunciation guide is "eh-a-fiatla-jokult" - gottal stop on the last "t".
The floods that come out of the glaicers -from all the melting ice are call jokulhaups.
Anyway pyroclastic flows are the result material collapsing out of an ash column - they're also called pyroclastic density currents and they can happen at a range of scales. The whole cloud doesnt have to collapse all at once, but bits can fall out of it as the main cloud continues to rise. Ngauruhoe in the 70's had small ones that only made the foot of the cone - whereas other ones (such as from Taupo) travel hundreds of kilometres - the deposit is then called an ignimbrite and if it's hot enough when it lands it will weld together into a solid rock. What you might be mistaking for a pyroclastic flow in the Auckland video is a base surge which is kind of a low angle PDC that comes straight out of the vent at an angle rather than going up in a cloud and then collapsing. A base surge is the result of interaction of magma and water, so if an Auckland volcano erupted in the harbour, a base surge is what you'd get.
Cracker: Wallywood, 16:35 Mar 11, 2010
I rather like my own suggestion for that sign on the hill next to the airport.
whoop whoop pullup!
Hard News: Ready for the Big One?, 20:50 Mar 5, 2010
unfortunately !!!??!!!!
You sound disappointed.
hah! poor choice of words, *luckily* i meant.
@Yamis. The Waitaks are indeed made up of an old volcano that once existed to the west of AUckland. It is part of a chain of long dead volcanoes that exist offshore from Kaipara to the Waitak's. THey were formed when the plate boundary was much further west than it is today (may somewhere around where AK is today - except of course Ak didnt exist then). THat was about 20million years ago (20Ma). Around 10Ma the plate boundary moved east (rotated clockwise) and formed the Coromandel Peninsula. Then around 2-3Ma it moved east again and started to form the present day Taupo Volcanic Zone. East Cape is continuing to rotate clockwise and eventually the next volcanoes in NZ will probably form somewhere around W(h)anganui - but we're talking millions of years....
The Auckland volcanic field is unrelated to the present day (or past) plate boundary. It's what's called an Intraplate volcanic field, ie a volcanic field that forms within a plate away from a boundary. There's another one in Northland - Kaikohe that last erupted only 2ka. The Mumbai Hills are an older version of the auckland field, it's thought that activity moved nth from the Bombays which were active about 1Ma to the AVF which started about 250ka.
unfortunately that La Palma story is somewhat exagerated......
@Chris - thanks !
@ Hilary
The best place to look for overseas stuff is the usgs website.
http://earthquake.usgs.gov/earthquakes/recenteqsww/Quakes/quakes_all.html
they look after the global seismic network which is able to locate large earthquakes any where in the world. Our NZ network cant locate events too far outside NZ with any accuracy so we rely on the GSN for that info. A couple of NZ stations contribute to the global network. There's a link to it on the Geonet website under the Earthquakes tab - links.
@lucy
havent actually seen that TV3 program ...probably an omission on my part. bUt the estimated shaking intensity in the Wellington CBD from the 1855 quake is MM10 on the Mercalli scale. This is described as "Many buildings are damaged and most weak buildings are destroyed."
http://www.geonet.org.nz/earthquake/modified-mercalli-intensity-scale.html
Volcanoes are more my thing anyway ;-).
@Russell
assuming you're not meaning the pending Phoenix game....
http://www.gns.cri.nz/wellingtonfault/
The good news is that recent GNS research has shown the Wellington Fault ruptures more like every 900 years (on average) not every 600 years as previously thought. The last big one was about 300 years ago ,so plenty of time yet....
But that's just the Wellington fault. The nearby Wairarapa Fault last broke in 1855 and caused a magnitude 8.2 quake which would still be pretty, shall we say, exciting, in the wellington CBD.
@Hilary
The energy is derived as follows. In Chile the Nazca plate is moving eastward under the Sth American plate at the rate of about 70mm per year. This is along a plate interface of several 1000km's. Now not all of this interface moves freely, parts of it are "stuck" and dont move, yet they are still being pushed together at a rate of 70mm per year. Over hundreds of years this 70mm of movement is accumlated as a strain deficit in the plate boundary . 100 years = 7m of accumlated (yet not realised) movement. Eventually the accumlated strain builds up to be greater than the friction stopping the plates from moving freely and then the whole lot lets go causing massive earthquakes. In NZ we have a similar situation off the east coast of the Nth Island where the Australian and Pacific Plates meet. There are zones along the plate boundary between Gisborne and Wellington that are locked and arent moving at the rate they should be moving compared to the rest of the interface. We can tell all of this through very precise continous GPS measurements which show which parts of the country are moving at what rates. What we cant tell however is how much strain the locked interfaces are able to accomodate before they release. We can however map out roughly which parts of the plate boundary are more strained than other and therefore more likely to fail.
There are also things called "slow earthquakes" in which the accumulated strain is released over the period of several days or weeks (as opposed to seconds in a earthquake). Several of these have happened off the East Cape in last 10 years since we have had the technology to measure them. In the slow earthquakes you might get 20-30mm of movement occuring slowly over several days (normally it would take a year or 2 for this amount of movement), which because it is so slow doesnt cause an actual earthquake. This amount of movement equates to something like a magnitude 6 earthquake. So slow earthwquakes do a lot for preventing bigger earthquakes. http://www.gns.cri.nz/news/release/gisborne.html
The moon has very little effect, as even though it is large it is very far away so its gravitational effect is very small.
disclaimer: i work for GNS in GeoNet... :-)
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Current vitae and letter of interest should be emailed to Jacquelyn N. Kraps, Ph.D. at jkraps@ccwhc.org.
The Counseling Center is a tobacco free workplace.
The Counseling Center of Wayne & Holmes Counties (TCC) offers Master's level internship opportunities to qualified graduate students to facilitate their development in becoming highly trained clinicians preparing to work with children, families and/or adults in a community mental health setting.
Each intern develops a plan that assures a breadth of experience taking into account individualized training needs and interests in collaboration with the intern's university program. The process of critical thinking, hypothesis testing and other elements of the scientific method are engendered and integrated into experiential activities throughout the training process.
Master's level interns at TCC are responsible for the integrative care of multiple clients. Practice opportunities may include, but are not limited to, diagnostic assessment, individual and family treatment, and group therapy, with exposure to evidence-based clinical practices.
Interested applicants must be enrolled in a graduate program in counseling, social work, psychology, or related field. Strong applicants will have a basic understanding of professional practices and standards, demonstrate a willingness to be self-directed, have strong verbal and written communication skills, be able to accept constructive criticism, and be willing to apply supervisory feedback in ongoing practice. Evening hours may be required. Internship positions are not paid.
Each intern develops a plan that assures a breadth of experience taking into account individualized training needs and interests in collaboration with the intern's university program. The process of critical thinking, hypothesis testing and other elements of the scientific method are engendered and integrated into experiential activities throughout the training process. .
Supervision is an important training component of the internship. Each intern is assigned and meets with a primary supervisor to discuss clinical conceptualization; diagnosis; treatment planning; and professional, legal, cultural and ethical issues germane to the patients with whom they work. Consultation with staff clinicians including psychologists, psychiatrists, social workers, and counselors is supported.
Photographs by Sarah Robb and Christine Allman.


The 2015-16 midyear economic and fiscal outlook (Myefo) released on Tuesday was yet another chapter in the fairy story told by the Abbott and Turnbull governments that we don't have a revenue problem. The reality is that lower than expected revenue is behind the increase in cumulative deficits over the next four years from the $82.2bn expected in the May budget to the $108.3bn now forecast. Whereas in the next four years cumulative government expenditure is predicted to be $13.3bn less than was expected in May, cumulative revenue is down 2.1% – or $37.6bn over the next four years.
The treasurer, Scott Morrison, and the finance minister, Mathias Cormann, were at pains to say when releasing the Myefo in Perth that they had worked hard to keep the budget on track for a surplus through offsetting new expenditure with savings.
But whereas the May budget estimated a deficit this year of $35.1bn or 2.1% of GDP, the Myefo estimates this year's deficit will be $37.4bn (2.3% of GDP).
It continues the now very oft-told tale of budget deficit downward revisions.
But if expenditure is being contained – even cut to a small extent – where is the problem?
The problem is two areas: lower projections of GDP growth, which in turn brings in lower revenue.
Such a downgrade is to be commended because it would have been easy to keep a make-believe figure in the distant (and after the next election) future.
The revisions to nominal GDP growth flow from the big hit in the Myefo – that of lower prices for iron ore and our other major exports such as coal and natural gas. In the May budget the terms of trade in 2015-16 was expected to fall 8.5%; now it is expected to fall 10.5%. And while the budget hoped next year would see the terms of trade stabilise and indeed rise 0.75%, now 2016-17 expects to see another 2.25% fall.
The budget forecast iron ore prices at US$48 a tonne; now it is hoping for US$39 a tonne (already above the current market price, as noted in the press conference).
Metallurgical coal was estimated in May at US$90 a tonne; now it is US$73 a tonne. And oil prices (which have a strong influence on LNG prices) have been revised down from US$64 a barrel to US$43 a barrel.
That all leads to a large drop in expected revenue via company tax receipts from companies whose business it is to sell such products.
In the May budget, company tax receipts were anticipated to be $68.2bn; now it is 1.1% lower at $67.1bn. Throw in a $450m drop in expected revenue via the petroleum resources rent tax, a $1.35bn fall in expected superannuation fund taxes and $1.6bn less from gross income tax and you end up with $3.55bn less than was expected just six months ago via income and company taxes.
But no, we don't have a revenue problem.
Scott Morrison has made it clear since he became treasurer he thinks the problem of the budget is all on the spending side. The Myefo statement showed yet again – as if the story needed to be told again to make anyone other than those running our economy understand – that when it comes to increases in the budget the main culprit is not blowouts in spending, but lower than expected revenue.


Rosemarie, a good friend of mine made it interesting for me with piercings on her face and a shaved head on one side wearing a beautiful green floral dress. I didn't have the dexterity to to paint any of her piercings other than the ear-ring. Sorry Rosemarie… I do like your accessories!
The colours look strange in the early photos of the work as i took them with my phone camera.


text:
Question Man
The Oarsman Report
BREAKING: LAUSD Abruptly Introduces New Grading Policy Preceding End Of Semester
A Race Against time in Benghazi
Jacob Jimenez, Entertainment Editor
"13 Hours: The Secret Soldiers of Benghazi" is the newest movie by the famous director Michael Bay, known for The Transformers films. The movie is based on true events that happened in 2012. A group of U.S. mercenaries fight for their lives against a cruel group of Islamic jihadists.
The movie focuses on a team of mercenaries made up of ex-Marines, Army Rangers, and Navy Seals. They are stationed in an undercover C.I.A. base in Benghazi, Libya that no one knows about. The C.I.A. helps diplomats and operatives in the city. U.S. ambassador Chris Stevens (Matt Letscher) comes to talk to the locals to turn Libya into a capitalist country.
The ambassador is stationed in the U.S. Embassy with little security. On Sept. 11, 2012, a group of Islamic people starts to attack the embassy, trying to kill the ambassador. The mercenaries want to save him, but they don't have the jurisdiction to go ahead. This is when the movie gets interesting. The mercenaries have to survive for 13 hours until support comes after countless attacks on their base.
The movie was released Jan. 15th and made over $15 million on its opening weekend. The movie has big actors like John Krasinski (Jack), James Badge Dale (Rone), Pablo Schreiber (Tonto), and Max Martini (Oz). The movie got a rating of 7.6 out of 10 on IMDB.com and a 58 out of 100 on RottenTomatoes.com. It's your average military gung-ho movie with lots of action that keeps the viewer on the edge of their seat. The Oarsman gives "13 Hours" a 7.5 out of 10 because the movie is partly propaganda when it says ISIS was behind this attack. It is an overall good movie.
How is online learning going?
I'm okay with it and keeping up with my work (54%, 64 Votes)
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I can't access it due to no Internet/tech (8%, 9 Votes)
Balancing Beats and Books: Inside the Life of Rising Producer Aztro
A2B2's Night of Fire: Attending a COVID-19 Concert Livestream
Venice High Students and Teachers Reflect on 2020 with Their Spotify Wrapped
Opinion: "Selena: The Series" At Risk Of Missing The Mark—Even Before Its Release
Album Review: Oneohtrix Point Never Retreads Old Ground in New Ways on "Magic Oneohtrix Point Never"
Album Review: Ariana Grande's Positions
From casting calls to home studios: How have creatives showcased their work during COVID-19?
Expressing Identity Through Art
Separating the Art from the Artist: J.K Rowling
Remembering Guitar Legend Eddie Van Halen
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text:
Catalog The Alice Network » eBook »
IL: UG - BL: 5.9 - AR Pts: 23
Featuring an exclusive excerpt from Kate Quinn's next incredible historical novel, THE HUNTRESS
NEW YORK TIMES & USA TODAY BESTSELLER
#1 GLOBE AND MAIL HISTORICAL FICTION BESTSELLER
One of NPR's Best Books of 2017!
One of Bookbub's Biggest Historical Fiction Books of 2017!
Reese Witherspoon Book Club Summer Reading Pick!
The 2017 Girly Book Club Book of the Year!
A Summer Book Pick from Good Housekeeping, Parade, Library Journal, Goodreads, Liz and Lisa, and BookBub
In an enthralling new historical novel from national bestselling author Kate Quinn, two women—a female spy recruited to the real-life Alice Network in France during World War I and an unconventional American socialite searching for her cousin in 1947—are brought together in a mesmerizing story of courage and redemption.
1947. In the chaotic aftermath of World War II, American college girl Charlie St. Clair is pregnant, unmarried, and on the verge of being thrown out of her very proper family. She's also nursing a desperate hope that her beloved cousin Rose, who disappeared in Nazi-occupied France during the war, might still be alive. So when Charlie's parents banish her to Europe to have her "little problem" taken care of, Charlie breaks free and heads to London, determined to find out what happened to the cousin she loves like a sister.
1915. A year into the Great War, Eve Gardiner burns to join the fight against the Germans and unexpectedly gets her chance when she's recruited to work as a spy. Sent into enemy-occupied France, she's trained by the mesmerizing Lili, the "Queen of Spies", who manages a vast network of secret agents right under the enemy's nose.
Thirty years later, haunted by the betrayal that ultimately tore apart the Alice Network, Eve spends her days drunk and secluded in her crumbling London house. Until a young American barges in uttering a name Eve hasn't heard in decades, and launches them both on a mission to find the truth...no matter where it leads.
"Both funny and heartbreaking, this epic journey of two courageous women is an unforgettable tale of little-known wartime glory and sacrifice. Quinn knocks it out of the park with this spectacular book!"—Stephanie Dray, New York Times bestselling author of America's First Daughter
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20170606 William Morrow & Company Unknown
3 copies, 18 people are on the wait list.
1 of 1 Online Hoopla Collection
OverDrive HarperAudio
Hoopla Unabridged. HarperAudio, 1 online resource (1 audio file (15hr., 07 min.)) : digital.
OverDrive HarperCollins
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B01LZFL63S
Lexile code:
Kate Quinn. (2017). The Alice Network: A Novel. HarperCollins.
Kate Quinn. 2017. The Alice Network: A Novel. HarperCollins.
Kate Quinn, The Alice Network: A Novel. HarperCollins, 2017.
Kate Quinn. The Alice Network: A Novel. HarperCollins, 2017. Web.
There are 36 holds on this title.
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Kate Quinn is a native of Southern California. She attended Boston University, where she earned bachelor's and master's degrees in classical voice. A lifelong history buff, she has written four novels in the Empress of Rome Saga and two books set in the Italian Renaissance detailing the early years of the infamous Borgia clan. All have been translated into multiple languages. She and her husband now live in Maryland with two black dogs named Caesar and Calpurnia.
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In an enthralling new historical novel from national bestselling author Kate Quinn, two women—a female spy recruited to the real-life Alice Network in France during World War I and an unconventional American socialite searching for her cousin in...


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Winter CHA booth to you via blog!
A chapel says many things, but one of the first things that I think of is a wedding!
sky peeking out from behind the chapel, so I used a die-cut to create a scalloped back-drop.
A little heart at the top and you know that the marriage will be blessed with love!
so be sure to check-in at your favorite online store or local retailer shortly thereafter!
Glad to have you drop in today...I'll be back tomorrow!