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European Commission Approves Brineura™ (cerliponase alfa), the First Treatment for CLN2 Disease, a Form of Batten Disease and Ultra-Rare Brain Disorder in Children
Dosing includes all ages from birth for this fatal and rapid pediatric neurodegenerative condition
Brineura is among first therapies to go through European Medicine Agency's new accelerated assessment process
SAN RAFAEL, Calif., June 1, 2017 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (Nasdaq:BMRN) today announced the European Commission (EC) has granted marketing authorization for Brineura™ (cerliponase alfa), the first treatment approved in the European Union for the treatment of neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase 1 (TPP1) deficiency. The dosing administration includes all ages from birth.
On April 21, 2017, the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMA), adopted a positive opinion for the company's Marketing Authorization Application (MAA) for BrineuraTM (cerliponase alfa) following an accelerated review procedure, reserved for medicinal products expected to be of major public health interest. The EMA revised process for accelerated assessment came into effect June 1, 2016. Brineura is one of the first therapies to go through this process.
CLN2 disease is an ultra-rare, rapidly progressive fatal brain condition, which affects an estimated 1,200 to 1,600 children worldwide, many of whom are undiagnosed. These affected children completely lose the ability to walk and talk around 6 years of age. During the later stages of the disease, feeding and tending to everyday needs become very difficult with death usually occurring between 8 and 12 years of age.
"Today represents several important milestones for the medical and patient communities, and also for me, both professionally and personally. For the first time since entering this field nearly 15 years ago, I can now tell families affected by CLN2 disease that there is a meaningful treatment that may help their child, and provide hope," said Angela Schulz, M.D. Ph.D., Department of Paediatrics, Children's Hospital, University Medical Center Hamburg-Eppendorf and principal investigator of the Brineura studies. "We are committed to furthering the study of Brineura and believe that the medical knowledge gained from the Brineura studies can help us learn more about treating other neurodegenerative diseases."
Brineura, an enzyme replacement therapy, is the first to be directly administered to the brain, treating the underlying cause of the condition by helping replace the deficient TPP1 enzyme. Using an established route of administration most often used in oncology – intracerebroventricular administration– the therapy is delivered directly into fluid surrounding the brain, known as the cerebrospinal fluid.
"Thank you to the European Commission for recognizing the medical benefits of Brineura for children affected by CLN2 disease. We are also grateful to the families and study investigators and their teams, who dedicated their time to the clinical program to make this treatment a reality for affected children in the EU," said Jean-Jacques Bienaimé, Chairman and Chief Executive Officer of BioMarin. "The physicians and patient families that form the Batten disease community have been integral to the approval of this treatment. We are also working to reduce the diagnostic journey for patients, who are often not diagnosed until the age of five, nearly two years after their first seizure. With a treatment now available, accelerating early diagnosis will be critical."
In Europe, BioMarin supports programs for molecular and enzymatic diagnosis of CLN2 disease, including the early use of gene panels with the goal of helping reduce the average age of CLN2 diagnosis.
On Apr. 27, 2017 the U.S. Food and Drug Administration (FDA) approved Brineura™ to slow the loss of ambulation in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase 1 (TPP1) deficiency.
The Brineura Marketing Authorization Application (MAA) was based on an open-label, dose-escalation study for Brineura in 24 patients with CLN2 disease between 3 and 8 years of age, as well as an open-label extension study. The primary objectives were to evaluate the safety and tolerability of intracerebroventricular-administered Brineura and to evaluate effectiveness using a CLN2 disease-specific rating scale score in comparison with natural history data after 48 and 72 weeks of treatment.
The clinical study has shown that at 48 weeks, 87 percent or 20 of the 23 children who completed the trial did not decline in motor and language score. In the study, the mean rate of decline in patients treated with Brineura at 300 mg. every other week was 0.40 points per 48 weeks. When compared to the expected rate of decline based on the natural history, the study results are statistically significant (p<0.0001). The observed treatment effect was considered clinically meaningful in light of the natural history of untreated CLN2 disease. In the ongoing study as of June 3, 2016, the rate of decline in patients treated with Brineura compared to the natural history control group (N=42 patients) continues to show durability of the treatment effect.
In the clinical study, intraventricular access device-related infections were observed in two patients. In each case, antibiotics were administered, the intraventricular access device was replaced and the patient continued on Brineura treatment.
Hypersensitivity reactions have been reported in 14 (58%) Brineura treated patients during the clinical studies. The most common adverse reactions are convulsions, pyrexia, decreased cerebrospinal fluid (CSF) protein, ECG abnormalities, vomiting, upper respiratory tract infection, hypersensitivity, irritability, increased CSF protein, headache, needle issue and CSF pleocytosis.
About CLN2 Disease
Children with CLN2 disease typically begin experiencing seizures between the ages of 2 and 4 years old, preceded in the majority of cases by language development delay. The disease progresses rapidly with most affected children losing the ability to walk and talk by approximately 6 years of age. Initial symptoms are followed by movement disorders, motor deterioration, dementia, blindness, and death usually occurring between the ages of 8 and 12 years of age. During the later stages of the disease, feeding and tending to everyday needs become very difficult. BioMarin estimates the incidence of CLN2 disease is approximately one in 200,000 with up to 1,200 to 1,600 children in the regions of the world where BioMarin operates, many of whom are undiagnosed.
The neuronal ceroid lipofuscinoses (NCLs) are a heterogeneous group of lysosomal storage disorders that includes the autosomal recessive neurodegenerative disorder CLN2 disease. CLN2 disease is caused by mutations in the TPP1 gene resulting in deficient activity of the enzyme tripeptidyl peptidase 1 (TPP1). In the absence of TPP1, lysosomal storage materials normally metabolized by this enzyme accumulate in many organs, particularly in the brain and retina. Buildup of these storage materials in the cells of the nervous system contributes to the progressive and relentless neurodegeneration which manifests as loss of cognitive, motor, and visual functions.
About Brineura
Brineura is a recombinant form of human tripeptidyl peptidase 1 (TPP1), the enzyme deficient in patients with CLN2 disease. It is an enzyme replacement therapy designed to restore TPP1 enzyme activity and break down the storage materials that cause CLN2 disease. In order to reach the cells of the brain and central nervous system, the treatment is delivered directly into the fluid surrounding the brain (cerebrospinal fluid) using BioMarin's patented technology.
Brineura administered via intracerebroventricular infusion every other week was well tolerated, and no patients discontinued treatment due to adverse events (AEs). Most AEs were Grade 1 or 2, and the majority are consistent with severe, chronic neurologic disease in pediatric patients. The most common events associated with treatment included: pyrexia, hypersensitivity, seizure, epilepsy, vomiting and headache. In Europe, dosing for children under two has been estimated based on brain mass. Limited data are available for children aged 2 years, and no clinical data is available in children below 2 years of age. While safety and efficacy of Brineura in children less than 3 years of age has not yet been established, BioMarin is conducting a study in this patient population.
About BioMarin
BioMarin is a global biotechnology company that develops and commercializes innovative therapies for patients with serious and life-threatening rare and ultra-rare genetic diseases. The Company's portfolio consists of six commercialized products and multiple clinical and pre-clinical product candidates. For additional information, please visit www.BioMarin.com.
This press release contains forward-looking statements, including, without limitation, statements regarding the potential benefits and commercial availability of Brineura™ (cerliponase alfa). These forward-looking statements are based on the Company's current beliefs and expectations and involve risks and uncertainties such that actual results may differ materially from these statements. These risks and uncertainties include, among others, risks related to: uncertainties inherent in research and development, including unfavorable new clinical data and additional analyses of existing clinical data; the commercialization of Brineura; the Company's ability to manufacture sufficient quantities of Brineura for clinical trials and the commercial launch of Brineura; the market potential for Brinuera as a treatment for CLN2 disease; competitive developments; and those other risks detailed from time to time under the caption "Risk Factors" and elsewhere in the Company's Securities and Exchange Commission (SEC) filings, including the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2017, and future filings and reports by the Company. The Company undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events or changes in its expectations.
BioMarin® is a registered trademark and Brineura™ is a trademark of BioMarin Pharmaceutical Inc.
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Batman: Arkham Origins Will Finally Feature The Batcave
By Ishaan August 20, 2013
The latest trailer for Batman: Arkham Origins reveals Firefly as one of the game's main villains, and also that the Batcave will finally be featured in an Arkham game. Watch the trailer below:
Batman: Arkham Origins will be available for PC, Xbox 360, PlayStation 3 and Wii U on October 25th. A side-scrolling Metroid-esque platformer titled Batman Arkham Origins: Blackgate will be available for Nintendo 3DS and Vita on the same day.
More in PC
Hardcore Mecha Adds a new Simulation Mode & More in Simultaneous Update

redpajama_set_name: RedPajamaCommonCrawl


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Categories › Model Kits › 1:24/1:25 Road Cars › 1:24 Toyota AE86 Trueno 1983 (Initial D) Takumi Fujiwara Model Kit
1:24 Toyota AE86 Trueno 1983 (Initial D) Takumi Fujiwara Model Kit
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1:24 Toyota AE86 Trueno 1983 (Initial D) Model Kit
Car: Toyota Sprinter Trueno GT-APEX (AE86)
Takumi Fujiwara (藤原 拓海 Fujiwara Takumi?, "Tak") is the central character in the Initial D series. Although he appears to be just a high school senior with no remarkable traits, he had been subtly groomed by his father into becoming one of the best street racers in the area. This is due to his job of delivering tofu over the mountain roads to Lake Akina every morning for five years while driving a 1983 Toyota Sprinter Trueno AE86. He works part-time at a gas station with his best friend Itsuki Takeuchi, and the leader of the Akina Speed Stars, Iketani.Ch. 1 Although he is totally disinterested in racing, when his friends were discussing drift techniques and Takumi's suggestion of a technique is dismissed as amateur, his boss Yuichi Tachibana realizes Takumi's technique is a much more advanced.[a]Ch. 3 After passing Keisuke Takahashi on the roads, he begins to find himself involved in challenges to race, which he initially agrees to do for petty rewards from his father such as getting to use the car for pleasure and having a full tank of gas.Ch. 7 He initially disregards comment about him being a street racer and loving to drive, but slowly he accepts the idea that he enjoys the thrill of street racing. Although he is not a member of the Akina Speed Stars, he soon races all sorts of challengers from teams over the region and nearby. In the Fourth Stage storylines, he joins Ryosuke Takahashi's Project D, which aims to conquer street racing teams in other prefectures.
Although Takumi appears docile and weak-minded in the series, he occasionally shows stubbornness and strong will, as he was once coaxed into a fight in junior high.Ch. 1, 19 He attracts the affections of classmate Natsuki Mogi, but their relationship sours when he discovers the latter has been doing enjo kosai (subsidized dating / teenage prostitution). In the Fifth Stage storylines, he begins a friendship with Mika Uehara, a high school senior who is a golfer.
Takumi is voiced by Shin-ichiro Miki in the Japanese anime series,[b] and by Mamoru Miyano in the 2014 film.[2014 film] He is nicknamed Tak in the Tokyopop version, and is voiced by Dave Wittenberg in its English dub in the 1990s.[b] In Funimation's English dub of the anime in the 2000s, he is voiced by Joel McDonald.[b] In the Hong Kong live-action film, Takumi is portrayed by actor Jay Chou.[LA]
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Mike Ellsworth SNS, Uncategorized
StratVantage Consulting, LLC — StratVantage News Summary 10/02/01
From Evernote:
Clipped from: http://www.stratvantage.com/news/100201.htm
Wireless Almost Usable
User interface guru Jakob Nielsen has been a curmudgeon about wireless devices ever since they started sprouting interactive features. He's an advocate of the plain and simple, and of intuitive interfaces. So there's no wonder he hated the phones that make you press the "7" key four times to type an "S". After his visit to the recent DEMOmobile conference in La Jolla, California, however, Nielsen's changing his tune, at least somewhat.
First off, he found a number of interesting wireless developments at the conference:
iPaq is now the mobile device of choice and was the platform for almost all new services. I've noted this trend myself, and that has led to a re-ranking of Personal Digital Assistant (PDA) technology in the TrendSpot this month. According to Nielsen, last year, most start-ups based their systems on Wireless Application Protocol (WAP) phones, which is now widely viewed as a limited and wounded technology. At the conference, virtually all presenters now see WAP as doomed. Nielsen, a strong WAP opponent, agrees: "Think of the hundreds of millions of dollars that could have been saved last year if the VCs had bothered running a WAP usability study ."
Palm is still around, but used by dramatically fewer services at this year's conference than last year. Palm's inability to capitalize on its command lead in PDA sales by offering a decent development environment may have led to its loss of market share. Its primary advantages nowadays are its ubiquity and its smaller size. Plus, it may have been a blunder to offer a proprietary device plug in standard, unlike the iPaq and other Pocket PC PDAs, which use standard PC Cards. Sony may yet be able to morph the Palm into a consumer device, but the ease of programming and porting existing applications onto the Pocket PC platform could well spell the end of Palm's dominance.
The PC is emerging as a personal server that supports a user's mobile devices, often through its wired Internet connection. This is an interesting new trend, an extension of the PC's role in synching contact and calendar information. For example, SimpleDevices downloads music to the PC and transmits the audio files wirelessly to the user's car when it is within range. How cool is that? Nielsen notes that although SimpleDevices can't support real-time news, it does offer a virtual broadband connection to the car.
Cheap humans add value to the network. (Editorial Aside: One of the problems of this world is that there are cheap humans, IMHO). "Copytalk and Webhelp both presented ingenious ways of injecting full intelligence into a mobile system," Nielsen said. "Users simply speak their information request; the system then compresses the audio recording into a data file and transmits it through the Internet, to locations where highly qualified labor is virtually free." This makes possible all kinds of services, such as a human-powered AskJeeves -like service. According to Nielsen, a human expert at web searching could research the user's question and transmit the answer back for less than a dollar. Once the answer arrives, it can be converted to speech using text-to-speech synthesis and played for the user.
802.11 is now the wireless connectivity of choice and, according to Nielsen, was used by almost everybody at the conference. This is a big change from last year, when Bluetooth was on the rise. This year, Bluetoon was almost gone, Nielsen said. Followers of the TrendSpot know that I have downgraded Bluetooth consistently over the last three months, and this month is no different. But now there's a growing feeling that 802.11b, the short range wireless network technology, combined with Voice over IP (VoIP), a technology that routes phone calls over the Internet, could threaten cell phone networks as well. This has given 802.11b a boost in the TrendSpot rankings this month.
Although Nielsen was generally positive about one new device that debuted at the show, Danger Research's Hiptop (OK, that's a stupid name alert times two!), he had some criticisms of its user interface. The Hiptop, which people at the show were calling the Danger Device, is a 6-ounce Personal Digital Assistant (PDA) and a cell phone device with a a small but readable grayscale screen. The device has a thumbwheel control and a few visible buttons, leaving most of the room for the screen. You can browse the Web (with full graphics), send and receive e-mail and instant messages, or use it as a phone. The Hiptop also lets you take pictures, and play video games and other Java programs. What's really nice, however, is the teeny thumb keyboard that you can expose by twisting the device.
The bummer for US wireless users, however, is that the Hiptop is a GSM phone, which means only Cingular and Voicestream will be able to sell it here, for about $200. Since GSM networks in the US are just getting started, that means accepting less-than-optimal coverage for the privilege of having the coolest wireless device on the block.
Nielsen is not convinced that tiny keyboards are the solution for mobile devices, putting his bets on improved handwriting recognition (it would have to improve a lot to read mine) and voice recognition. He also doesn't like trackwheels, calling them unnatural (but then so was the mouse the first time you used it, yes?).
Whether the Danger device becomes the next big thing here will depend a lot on the progress of GSM and its successor, GPRS, in the US. With the first GPRS networks launched recently in China, England, and, incredibly, Seattle , the pervasiveness of this particular device will depend a lot on how quickly wireless network providers build out their networks.
UseIt.com
Briefly Noted
Shameless Self-Promotion Dept.: I've added a new directory to the Directories section of the StratVantage Web site: Email Newsletters. After conducting a fruitless search for a central place listing interesting email newsletters, I decided to establish one myself. I've seeded it with newsletters I receive and find useful. If you've got a favorite, send it along and I'll add it.
StratVantage Directories
Nokia Covering Its Bets: As reported in issues of SNS (here and here ), Nokia is very interested in m-commerce (mobile eCommerce). In addition to its joint SmartCover effort with Sodexho and its dual chip test with Visa, Nokia is collaborating with IBM, Luottokunta and Radiolinja to pilot secure credit card payments using a mobile phone wallet application. The participants hope to demonstrate using the wallet for transferring payments and loyalty program information, and WIM (Wireless Identity Module) for making non-repudiated transactions. The parties are in the process of choosing suitable merchants for the pilot, which will start in the fourth quarter of 2001 in Finland.
Java on the Phone – Your Desktop Phone: By now my prediction last spring that it would be a while before we saw Java on mobile phones seems pretty ludicrous. Not long after I made the prediction, Korea's LG Telecom introduced a Java-enabled cell phone in July, Nextel announced a Java cell phone, and Nokia smart phones, available outside the United States, began using Java applications. Now Kada™ Systems has announced that Cisco will build their Java technology into its Voice over Internet Protocol (VoIP) non-mobile desktop phones. Sometimes the magic works, and sometimes it doesn't.
Kada Systems
Single Sign-On = Liberty? Nokia, Cisco, Dun & Bradstreet, Sony, Sun and many other companies have announced that they will co-found the Liberty Alliance Project "to create an open, standards-based solution for network identity and authentication to provide single sign-on to the internet and to the mobile Internet." They propose to do this through a technique they're calling federated identity. "In a federated view of the world, a person's online identity, their personal profile, personalized online configurations, buying habits and history, and shopping preferences are administered by users, yet securely shared with the organizations of their choosing. A federated identity model will enable every business or user to manage their own data, and ensure that the use of critical personal information is managed and distributed by the appropriate parties, rather than a central authority."
Notably missing from the roster of founding members is Microsoft, which wants the world to adopt its proprietary Passport technology. About the name Liberty Project, though: I squirm a bit when I see projects named in this manner. What's next? The Mom & Apple Pie Project? Nevertheless, it's way too early to say whether this project will enhance our online freedom or detract from it.
Project Liberty
Too Many Clues: Was I the only one who thought the abundance of clues left by the terrorist hijackers was a little fishy? Apparently not, as an article on Stratfor indicates. The article states that the terrorists, "practiced near-perfect operational planning, coordination and execution before their mission but left behind obvious evidence leading to other operatives who may have supported the hijackings. This begs the question of whether these evidence trails were intentionally left in order to distract U.S. law enforcement from other terrorists." The article is well worth reading.
DoCoMo Starts First 3G Service: With no fanfare, Japan's DoCoMo has started selling 3G phones that feature video services. The company thus met the timeline it announced late last year. I was among the skeptics that thought they'd never make it. Although the rollout is limited to a 30-mile radius of Tokyo, it soon will spread to other Japanese cities. The service, dubbed FOMA, (Freedom of Mobile multimedia Access), offers download speeds as high as 384Kbps. One of the phones the company is selling has a built-in camera for wireless videoconferencing. DoCoMo sold 4,000 phones the first day.
AllNetDevices
Sprint Stops Whining; Debuts E911 Phone: You never heard such a bunch of whining as the din put up by US wireless carriers about having to meet the FCC's E911 mandate by this month. Verizon led the pack with detailed whines about how it couldn't comply. VoiceStream got a waiver. But Sprint has amazed us all by offering an E911-compatible phone right on time. E911 is an FCC rule requiring cell phone network operators to be able to locate a phone within 100 meters. Although Sprint is offering the phone, Samsung's SPH-N300 GPS-enabled phone, it is not yet supporting it with network services. Nonetheless, way to go!
Commitment to Make a Difference: Karen Holtzblatt, a principal of design services consultancy InContext, made the following commitment after the recent tragedy. Many other business people have made the same pledge:
When the NYSE re-opened, we bought and will buy stock in a company we believe in (and which gave generously to recovery and victim relief).
We will commit people and money to a development project that improves people's lives.
We will fly and attend conferences and business meetings.
We will collaborate with colleagues–and competitors–to improve what we make and how we work.
We will watch our spending but not make frivolous cuts that hamper productivity.
We will invest in helping others secure a livelihood.
We will affirm our safety, security, and joy in living by spending on something fun.
We will work to help the triumph of openness, tolerance, and understanding over fear, hatred, and violence.
InContext
Microsoft's .NET Could Be Virus-Prone: Eric Chien, chief researcher for antivirus firm Symantec, has identified a number of areas in which .NET, Microsoft's next generation Web services platform, could be even more vulnerable to security threats than existing Microsoft operating systems. Chien said: "There are a number of new threats here, most of which are dependent on how users set their permissions and other security settings." Another vulnerability is .NET's ability to run programs in a variety of different languages, many of which currently have no antivirus products available. Chien's primary worry, though, is that users won't know how to use the various security resources within .NET to protect themselves. Sounds like good news for Chien's employer, though.
Silicon.com
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StratVantage Consulting, LLC — Mike's Take on the News 09/27/01 StratVantage Consulting, LLC — Mike's Take on the News 10/11/01


If you live in Hollywood, Los Angeles and you need your carpets and rugs cleaned, you'd better order the services of Residential Carpet Cleaning Hollywood. We have many pleased customers and our work is performed in accordance with the highest standards in the carpet cleaning industry. You can count on us for any problems which might need to be solved and we can provide urgent assistance if necessary.
Hollywood is also known as the Entertainment Capital of the World.
The area continues to be the center of the filming industry and many movies are being shot here every year. If you visit Hollywood, there are so many interesting places to see that a week won't be enough. You can choose between well-known buildings, famous hotels and of course, the movie studios and all the unique theaters in the area.
Residential carpet cleaning is closely related to preservation of the overall health of people. As all rugs, furniture and curtains gather dust and dirt with time, small children or old people can develop allergies, asthma, respiratory problems – such conditions can cause a lot of discomfort and can also be quite dangerous. That's why you need to remove dirt and dust regularly and our company can provide the best assistance in the area. We work with skillful specialists, who have gained a lot of experience and are trained to remove efficiently any stain. Our services include the sending of a team to your house – they will check the carpet or the upholstery for the type and composition of the fabric – when our employees gather all available information, they can decide which technique will be used. The proper cleaning devices also depend on the severity of the damage or the dirt levels. The dustier a rug is, the more bacteria can appear and we will have to use special solutions to kill all existing germs.
Besides carpet cleaning, you can order our services for your upholstery, curtains, tiles etc. Pieces of furniture can be quite difficult to clean as there are all kinds of crevices, curves and holes which are not easily reached with bare hands. We have devices with the appropriate particles which will clean even the hardest places to reach. You also need to be very careful with the upholstery fabric as there are types which shrink after washing. That's why we determine the components of the fabric first and then we usually use the steam cleaner – the results are excellent. Another important thing about carpet and furniture cleaning services is that all items should be left as dry as they were in the beginning. We will provide devices which will extract the moisture from the fabrics and leave them absolutely dry. For instance, if any part of your carpet is left wet, mold can appear and this may ruin the whole item irreversibly.


So, What DO they Remember After All of That?
Nearing the end of the fast paced, often crazed, multi-layers of multitasking…planning and grading, teaching and re-teaching…what is it that kids remember of their school year with you? What do they find meaningful and lasting from your time together?
It's worth stopping to see, because it's the glue that holds all the rest together.
I had that opportunity when Mrs. Patterson, a retired teacher, took over my 5th grade class when I went to a meeting. She had my students write me a thank you/memory letter. And just what is it that really made an impact after our nine months together? The hours spent putting together that cool project? Those math lessons taught three different ways until they all got it? No…my black boots with the blue zippers!
Here is one comment pulled from each letter.
I like when you freak out when something good happens.
You played a huge role in teaching us how to be good human beings and the ways that we can do that.
I truly didn't even know what a web 2.0 tool was before this year.
You aren't so quiet and boring. You are kind of loud actually.
I think that you are funny, and I love that about you.
I let my brain run free and have a say!
You know how to keep people going, and you don't give up on yourself. I never gave up because of you.
I loved watching Carl on CNN Student News.
You always like to swing at recess.
I love being able to do stuff that my sister, brother, dad, and mom can't do on the computer!
You are very funny, but in a good way. Thanks for making us laugh.
Our classroom feels like home to me.
I love blogging, can we still do it over the summer too?
You have great taste of style! I love your black boots with the blue zippers.
I don't know about you, but I've never heard of some of the places in the world that we worked with or skyped.
Even though you won't be there personally, you will always be with me.
Well, I only have a minute to gather my life and get to the bus so…THANK YOU!
Does knowing this help me with all of the work ahead for next year? No…but it sure puts things in perspective. You may want to give it a try before they're gone for the year.
Music is good for the soul. Share the love. Donating the cost of one lesson that we may pay for our own kids goes along way for these kids.
The Chicago Metamorphosis Orchestra Project (ChiMOP) is a community youth orchestra program dedicated to affecting positive social change in young students with limited access to the arts by providing a safe and fun environment for them to make music in pursuit of artistic excellence together with peers and role models.
Currently, ChiMOP has two programs. The Summer Orchestra Camp, launched in May 2013, and a school partnership program with Mary Lyon Elementary School, launched September 2013, that provides daily group lessons, string orchestra, wind ensemble, symphony orchestra, bucket band, and choir as well as opportunities to perform and attend concerts around the city throughout the year for more than 100 young students in the Belmont Cragin community. All program costs are completely free to all students.
To see the whole post: Click HERE for more information.


This site and blog are dedicated to all of our friends and family who have journeyed with us and continue to journey with us. Our prayer for each of you is that God would reveal Himself to you in ways that go beyond our understanding (Isaiah 55:8), and that you would live your lives in such a way that would glorify and honor Him.
Back in January, Carolyn and I made the decision to move and downsize our home. As Carolyn noted in her 90-10 post, our primary goal is to put ourselves in a situation where we can give more.
Since her post, we have put our current house on the market and purchased a new home for considerably less than the one we're living in now. But here's the kicker: Even though we both felt called by the Lord to make this move, we haven't been able to sell our house.
I mean, if the Lord calls you to do something, shouldn't everything just fall into place? In all honesty, that's what I thought would happen. If we're obeying the Lord's call in our lives, shouldn't He just act accordingly?
Well, it turns out, He is.
Over the course of the last couple of months, Carolyn and I have found ourselves frustrated. And it's not a frustration because we don't believe our house will sell, because we do. And it's not a frustration because we're having second thoughts on what God's called us to do, because we're not. On the contrary, we are more passionate than ever about God's calling on our lives to "want less" and "want Him more".
Quite simply, the frustration that we're experiencing is because we're not satistfied with how quickly (or slowly) this process is moving along.
"Are you kidding me? Really? You couldn't have taken a 7 minute drive up to Ilderton before booking the showing?" Those were the thoughts that penetrated my mind (and I'm sure Carolyn's too).
Within minutes, the Lord brought Scripture to my mind… and not a "consoling Scripture verse" that's often used in times of frustration or disappointment, but rather a very pointed event. The verse that He brought was when the Israelites were fleeing Egypt. Pharaoh had just released them, and upon doing so, changed his mind and went after them to bring destruction.
We could have stayed in our current house forever – a beautiful 4+2 bedroom home, tons of space, a great community, great neighbors and a nice backyard. But the fact of the matter is, if we did, we would continue to be slaves to mortgage debt, lost opportunity, and most importantly, we would be ignoring the Spirit that has been calling us to do this for a long time.
If we fall flat on our face because we chose to obey God, I can live with that. If we fall flat on our face because we ignored His calling, I can't live with that.
God made the Israelites march around the walls of Jericho seven times (Joshua 6). He could have just taken the walls down. He waited until the very last days to give Sarah a child (Genesis 21). He could have given Isaac to her in her youth. He made David wait 15 years to become king of Israel (2 Sam. 5). He could have just crowned David when Samuel anointed him (1 Sam. 16).
This period of waiting is purposeful.
Our house will sell when He wants it to sell.
In Him, we put our trust.


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Santos' election fraud probe: 'the disaster scenario is that' Colombia's 'establishment goes down'
by Adriaan Alsema December 16, 2019
Weekly Semana has published wiretap extracts that clarify how the 2014 re-election campaign of Colombia's President Juan Manuel Santos allegedly received illegal campaign funding.
What is curious is that the corruption-riddled prosecution has so far failed to interrogate the two key witnesses who would be able to confirm the alleged funneling of illegal funds from banking giant Grupo Aval and Brazilian engineering firm to the Liberal Party.
Court asks Colombia's inspector general to sit on top of 'erratic' prosecution in Odebrecht cases
How the money was allegedly funneled
Andres Sanmiguel (Image: Prosecutor General's Office)
The prosecution is investigating the alleged funneling of almost $1.5 million (COP3900 million) from the consortium constructing the Ruta del Sol II project to the liberal party that supported Santos' campaign.
This money of Grupo Aval and Odebrecht would have been sent to a company called Gistic Logistics on July 9, 2014, three weeks after the second round of elections, the co-director of this company, Andres Sanmiguel, confirmed to prosecutors.
Sanmiguel testified in July last year that his business partner David Portilla asked him to withdraw the money and give it to Esteban Moreno, a businessmen who was reportedly involved in Santos' re-election campaign in the Valle del Cauca province.
According to Sanmiguel, Moreno told him the money was meant for "people of the Liberal Party," in particular Simon Gaviria, to cover a campaign deficit.
'Everyone's fucked'
Esteban Moreno (Image: El Heraldo)
Semana additionally released the extracts of the wiretaps in which Moreno told Sanmiguel that "everyone's fucked."
When these wiretaps were recorded is unclear. The suspects are on tape talking about the possible election of Nestor Humberto Martinez, the former Grupo Aval attorney who became Prosecutor General in mid 2016 but didn't open an investigation until after December 2016.
In the wiretaps, the businessmen additionally implicate not just Grupo Aval CEO Luis Carlos Sarmiento, but also a businessman with the same last name as Carlos Ardila, the boss of media empire RCN and soft drink company Postobon.
The disaster scenario (is) that they are caught and all are called [to testify] and the country goes on fire. I tell you one thing, if the president goes down, the prosecutor goes down, the candidacy of [Vice-President German] Vargas (and) the country's establishment go down.
Esteban Moreno
The key suspect the prosecution won't interrogate
Cesar (L) and Simon Gaviria. (Image: Flickr)
Despite his alleged key role in funneling the money from Sanmiguel to the Liberal Party, Moreno has yet to be heard by the prosecution, whose investigation has been riddled with irregularities.
Sanmiguel's business partner, David Portilla, who allegedly set up the deal with Grupo Aval and Odebrecht, also has yet to be heard.
Senator Armando Benedetti, who has been following the case, said last week that Moreno "is the one who has the keys to everything. If Moreno corroborates what they are saying the country's institutions come tumbling down."
So far, the prosecution has prevented exactly that.
Moreno, Portilla and Sanmiguel were supposed to be heard last week, but the hearing was postponed.
2014 electionselection fraudgrupo avalJuan Manuel SantosOdebrecht
One week after Colombia inaugurated mayors, four already in jail
Santos denies receiving illegal campaign funds from Odebrecht
Fugitive former congresswoman 'wants to surrender' months after spectacular jailbreak


The problem is all too familiar: a customer calls and asks why they were charged for 10 cases of product when they only received eight.
When a situation like this arises, often a distributor's customer service representative will tell the customer they will look into it and call them back. The rep then embarks on the time-consuming process of rummaging through filing cabinets that store hundreds of thousands of tickets. Once finding the delivery ticket in question, the rep then checks it over to see what had been delivered, makes sure the customer signed off on it and then calls the customer back. But sometimes a ticket cannot be found because it has been misfiled or lost. In these unfortunate cases there is no way for the distributor to prove that the product had been delivered to the customer, and the upset customer often will refuse to pay the bill.
However, some jan/san distributors, like Indianapolis-based HP Products, are sidestepping these scenarios by investing in proof of delivery (POD) software to streamline the otherwise outdated and pricey process of manually tracking down proof of delivery documents.
POD software is designed to help automate business processes in distribution environments that rely heavily on transactional documents, such as packing slips and delivery tickets. Specifically it's aimed at automating the process of verifying that goods have been delivered or received.
By capturing and storing electronic signatures and barcoded documents at the point of receipt, the latest POD software initiates the creation of an invoice and eliminates manual processes associated with matching and collating various paper documents. The software then allows authorized users, such as accounting and warehouse personnel to instantly view and retrieve related documents via their computer network.
Most notably, implementation of POD software allows jan/san distributors to eliminate losses caused by misfiled invoice copies with customer signatures, reduce the time spent to find delivery documents and provide immediate response when a customer requests proof of delivery, says Mark Willoughby, chief financial officer for HP Products.
Surprisingly, many distribution companies are still using the traditional paper-based method to track proof of delivery. In these instances, when delivery drivers return from their runs, invoices are typically delivered to management, who then distributes them to personnel who are in charge of filing them away.
But with as many as several hundred invoices per day being generated, a distributor's filing department can quickly fall behind. So, invoices could essentially sit in a stack, untouched for a day or two until staff can get to them.
Realizing that this method was requiring too much of its manpower, JanPak Inc., Davidson, N.C., implemented POD software into its operations a few years ago.
Currently, JanPak's delivery manifests are printed in the morning and distributed to its delivery drivers. On each manifest is each delivery stop, a designated place for a customer's signature as well as a barcode.
When the company's drivers make a stop, they have customers sign a printed invoice to verify that the correct product and amount was received. In some cases other important notations may be made on the invoice, such as that the entire order could not be delivered or that the customer has returned product from a previous order for credit.
"There's barcoding on it so when it's scanned its tracked back to the original order, and it takes the signature information, product information, the dated information, the piece count information, that hand written information and it puts it on the invoice," says Householder.
What's most important is the time it has saved the company's personnel from scanning in the hundreds of delivery tickets at the end of each work shift. Because the company's delivery manifests now can store up to 30 deliveries on one or two sheets of paper, it has consolidated the scanning process.
Once scanned, the system reads the bar code printed on each invoice, which contains the customer number, invoice number and document type. So, by the time the office opens the next morning, all of the invoices are scanned into the system and ready to view. If a customer calls the next day and says they were short a case of product, a customer service representative can easily look up any invoice on their computer screen and they can see a copy of the document the customer signed, stating exactly what they received. They then, at the customer's request, are able to fax or e-mail the proof of delivery to them within seconds, while the customer is still on the phone.
It's a much more streamlined process than having to page through thick reports to find the particular entry. Now, the customer service reps can simply type in whatever they know — the account number, customer name or the line item — and what they are looking for pops right up on their computer screen.
Although the process is light years ahead of what the company was doing three years ago, Householder says there is still room for improvement. In fact, he says the company envisions the day when it can go to the upper echelon of POD software and invest in electronic signature capture devices.
Unlike other methods of POD software, the implementation of electronic signature pads allows a distribution operation to eliminate the need for paper. For example, HP Products, which invested in these devices for its delivery drivers within the last year, is able to upload its packing lists onto the electronic devices at the beginning of each day, says Willoughby.
So, as delivery drivers make their number of stops throughout the day, they are able to obtain a signed proof of receipt from customers on the device itself at the point of delivery. Drivers can also make notes with the device if they did not deliver all of the items to a customer or accepted a return item. Then, when they return to the office after the last delivery is made, the information — customer signatures and notes — are downloaded into the company's computer system. This information is then automatically archived and can be retrieved via the company's computer network.
HP Products is expecting a huge payback for these devices by reducing lost proof of delivery documents, meaning they no longer have to eat costs from customers who are not willing to pay for a disputed delivery. The company has also been able to reduce paper usage costs because the electronic method eliminates the need to print reports. HP Products also has eliminated most collection problems due to the ability to provide proof of delivery within a reasonable amount of time.
Although the streamlined electronic process may be enticing, most distributors have balked at implementing these devices due to their upfront cost, says Householder.
While in a recession, distributors are looking to trim their operational costs. By investing in POD software, distributors may find that it is an investment that can have a great return.


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News / Corporate
Astellas and MBC BioLabs Announce Winners of Golden Ticket Competition to Support Biotech Start-ups Accelerate Early Drug Discovery and Innovation
Astellas Venture Management (President: Kazunori Maruyama, Ph.D, "AVM"), a wholly-owned venture capital subsidiary of Astellas Pharma Inc. and Mission Bay Capital BioLabs ("MBC BioLabs"), a...
Astellas Receives Approval of EVRENZO® (roxadustat) in Japan for the Treatment of Anemia of Chronic Kidney Disease in Adult Patients Not on Dialysis
Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas") and FibroGen, Inc. (Nasdaq: FGEN, CEO: Enrique Conterno, "FibroGen") today announced that Japan's Ministry of...
Astellas Receives U.S. FDA Fast Track Designation for ASP5354, an Investigational Near-Infrared Fluorescence Imaging Agent
Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas" ) announced today that the United States ("U.S.") Food and Drug Administration (FDA) has granted Fast Track...
U.S. FDA Grants Fast Track Designation for ASP0367/MA-0211, a Selective PPARδ Modulator being Developed for the Treatment of Primary Mitochondrial Myopathies
Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas" ) today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the...
Astellas and LabCentral Announce Golden Ticket Winners - Helping Emerging Biotechs Accelerate Growth of Innovative Science
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Game Changer is a collaboration between Improving Me, Widnes Vikings RLFC, Halton CCG and Sopra Steria to help improve the health and wellbeing of local young people.
The programme involves Vikings players and coaches providing wellbeing and exercise sessions in 36 Halton primary schools. By targeting children in years 2 to 4, the scheme is working with over 3,000 boys and girls in the area.
Delivered across a 24 week monitoring period, the children receive 12 weeks of focused support from Vikings through completing a combination of practical and classroom activities based around healthy eating.
While engaging the children in the physical activity sessions is a critical part of the Game Changer programme, changing parents and teachers habits to physical activity is essential. Through the scheme, schools will develop their own approaches to unlocking an extra 15 minutes of physical activity every day through their own innovative ideas and thus complete their Game Changer pledges. The project also includes a range of healthy eating workshops where children and parents will learn how to 'Eat Like a Pro' in partnership with Halton Health Improvement Team.


In the episode, our guests are La Yerba Ruda. They are a 9-piece reggae band that formed last year and has quickly made a name for themselves. They came on the show to talk about their next two shows, both here in Salinas. July 2nd they are at the Fox Theatre in Oldtown Salinas along with Big Mountain and July 15 they play a show at Casa Sorrento with Seedless who are fresh off playing Cali Roots.


Seven Angels, a famous girl band consists of 7 members from Indonesia is vacationing in Melbourne Australia and getting to know a local singer, Mark Moore. Mark takes them to Aradale Lunatic Asylum, a haunted former psychiatric home that stores a dark and terrible history. In the midst of critical conditions full of weirdness, one by one the secrets behind the thick wall that has existed since 1866, is revealed.


Its name "Velutina" suggests exactly the velvet green leaves that it has.
Its color is dark green and it has a shape that opens like a rose, which makes it ideal to be hung or simply placed in a bowl.
Very beautiful if combined with our Himmeli structure.
Spray or dip it in water just 2 times a month for a few minutes. A bright place is what it needs to grow well.


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redpajama_set_name: RedPajamaGithub


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Home News Newsfront
Waterfront Toronto/Nicola Betts
WHAT Sneak peek of Underpass Park, Waterfront Toronto's latest addition to the water's edge
WHERE West Don Lands, under the Eastern Avenue and Richmond overpass
WHY Official opening today (Thursday, August 2)
WEIRD SCENE
Five questions that haven't been asked about the latest internet storm to blow up around Rob Ford - this snapshot of the mayor taken at the New Year's Levee with Jon Latvis, former member of neo-Nazi band Rahowa, short for "racial holy war."
1. Some councillors can't even get face time with the mayor, so how did this turkey get a sit-down with Ford, allegedly to discuss "transit" issues?
2. What is it with extremists and "transit" anyway? Ford's transit adviser during the 2010 campaign, James Alcock, accepted an invitation to speak at white-rights guy Paul Fromm's Alternative Forum.
3. Is this Latvis business an isolated incident or a reflection of the ilk that occupies the fringes of Ford Nation? The mayors recent colour-coded musings on immigration laws and gun violence, not to mention gays, are bound to attract a few nutbars.
4. Why are the mayor's conservative friends at the Sun now trying to downplay Latvis's skinhead past. That is a swastika - sorry, cross of thunder - tattooed on Latvis's pasty white body in other shots that have appeared of him on the internet, right?
5. Shouldn't the dolt who set up the meeting with the mayor in the first place be fired over this?
Number of voters whose personal information was lost by Elections Ontario after two USB keys, left on the desk of an Elections Ontario employee, mysteriously went missing in April. The loss wasn't reported to the provincial Privacy Commissioner, Ann Cavoukian, until July. She revealed in a special report released this week that the agency failed to follow even the most basic security measures but says she is confident nothing more than the names, home addresses, dates of birth and gender of voters was contained in the USB keys. We won't know that for sure until the OPP finish their investigation.
Photo Ethan Eisenberg
Custom-made bikes and bike-related memorabilia were all part of the free-wheelin' fun at the inaugural Toronto Vintage Bicycle Show, presented by the Community Bicycle Network at Trinity Bellwoods Park on Sunday, July 29. The show attracted some 200 gearheads and passersby. Check out our slide show.
Greenpeace Canada campaigns director Yossi Cadan responds to an RCMP report detailing "criminal activity" by the group as part of a "growing radicalized environmentalist faction." Welcome to Stephen Harper's Canada, where civil disobedience against his buddies in Big Oil gets you labelled a radical and targeted by the cops for political repression.
HERITAGE WATCH
Enzo DiMatteo
What 1936 art deco fixture located on the former site of Montgomery Tavern where the Rebellion of 1837 was born.
Proposed The fear is condos, but Canada Post, which owns the building, is currently reviewing applications.
Backdrop Local Liberal MPP Mike Colle led a rally to preserve the building on Monday, July 30, but the area is held municipally by developer-friendly Karen Stintz.whose happens to be buds with Colle's son Josh, the councillor with whom she shares Eglinton-Lawrence.


4. Peter Musembi - Teacher Rep.
5. Esther k.Ngundo - Parents Rep.
This meeting was the third since inception of UGSST after the second one which was held at Kalumu primary school. The meeting took place at Nairobi and it was a non-costing meeting because it was a time squeeze event as most of the trustees were on their other businesses. The main aim of the meeting was to have a quick Review of the teachers recruitment and discussion of the proposal to be forwarded to TAS for possible funding.
1.1 Communication: Stephen Kameti informed members that he has discussed the issue with relevant persons even though no definite plan has been drawn. Stephen will be making further follow up to the issue with Mark Cheruiyot of KWS.
1.2 Additional Teachers Funding: Hellen Ndeti informed the members the proposal for additional teachers has been considered and already funds released to UGSST account with Chase Bank. She said the funds are for two years support as was requested.
1.3 Exchange program: Members requested Hellen and Stephen to make follow-up of the issue with Gill. Members felt this will be a great learning opportunity for both parties.
2.1 Additional teachers recruitment: The Principal informed members that two teachers have been recruited and filled their contract forms. This week one of the recruited teacher called the Principal and said he has found another greener pasture at the capital city-Nairobi. This means that the school is to recruit two more teachers by beginning of term year 2010.All members promised to join hands in sourcing for the two teachers. Pauline wife of the Local MP did promise also to assist in sourcing for the teachers. Members discussed the option of having incentives of the teachers who perform well in their respect subjects.Hellen Ndeti to make follow-up about the issue.
The Principal through the chair presented two proposals, small and big project which was considered as priority needs by the school BOG.
3.1 The large project; School Lighting Kshs 914,000.
The project has three quotation done by three companies (people) and the lowest is mr Charles Kyalo with the above amount . Members agreed Mr Kyao be given the tender because above his tender being the lowest his work in schools is well known in the area.Hellen was requested by members to forward the proposal to TAS.
3.2 Small project; Remedial teaching Kshs 100,000.
The school principal informed the members the schools' mean grade currently is very low; 2.7 compared to 12max. Members deliberated that proposal to be forwarded to TAS so as to enable start of the remedial program as early as first term for better results. Members felt that the proposal does not need quotations due to its application mode.
4.1 Hellen to do the two proposal and forward them to GILL; TAS by end Dec.2009.
The next meeting will be on 5th February 2010. The venue for the meeting to be determined by Gill's meetings schedule in Kenya.


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What Is Streaming?
Stay up-to-date on everything Streaming Media - Subscribe to Streaming Media Global XTRA and more today.
By Joel Daly Vice President Product Management at Telestream
Video Quality Monitoring in the Age of Time-Shifted Viewing
In all types of streaming services, providers have expanded on the traditional mode of archiving movies and TV programs for on-demand access by offering options like start-over, catch-up and cloud DVR. These strategies introduce many potential points of impairment to video quality that must be accounted for in the monitoring and troubleshooting processes service providers employ to maintain the best viewing experience.
Given the role time-shifted viewing is likely to continue playing in users' video consumption, service providers need to take these quality monitoring challenges into account. While it's true that far more OTT viewing time is spent consuming linear content than was once the case, on-demand viewing remains a critical component in streaming services.
Research from Omdia suggests that 2021 was the last year that the amount of time spent viewing linear content on TVs in the U.S. and the U.K. would surpass the amount of time spent viewing time-shifted content. Although household DVRs and subscriptions to OTT VOD services account for the lion's share of time-shifted viewing, new network-based options available through cloud DVR and catch-up/start-over services are rapidly gaining share as they become more widespread.
Indeed, consumers' desire to use cloud DVR in conjunction with viewing live-streamed services is now baked into many streaming services. In another report, Omdia said about 75% of total TV viewership in the U.S., U.K. and other large countries goes to linear content consumed either on schedule or from DVR storage, which, in the case of OTT streaming services like fuboTV, YouTube TV, Philo, Hulu, and Sling TV, is always cloud-based. Most major MVPDs in North America are offering cloud DVR services as well, even as many of their subscribers continue to use devices in the home.
Time Shifting Introduces New Points of Vulnerability to Video Quality
Whatever types of network-supported time-shifted viewing options service providers offer they must make sure viewing experiences comport with the subscriber's expectation. That's the case whether content is stored for 24 hours, a few days, or several months.
Consumers have little tolerance for sub-par quality when they are watching streaming content, especially when it comes to video consumed on the most dominant viewing device, the connected TV. Many studies show that it only takes a few hiccups in the viewing experience to drive them to another streaming service.
In catch-up and start-over operations, service providers must ensure content quality is always preserved with ingestion into storage as they cycle through the constantly shifting lineup of linear programming. And they must be able to confirm quality is preserved with each output from storage, whether it's from a turnkey cloud storage service or a CDN caching service.
The need to support the multiple bitrate profiles used with adaptive bitrate (ABR) streaming adds another complication. In some cases, the service provider chooses to avoid transcoding playout from storage by storing all profiles transcoded for linear distribution. In other cases, service providers choose to minimize storage costs by storing mezzanine copies of the linear streams and transcoding them into the required profiles as they're fed to origin servers. Either way, video quality monitoring and analysis must be applied to the origin outputs for each user.
These same principles apply to the pre-ingest and playout stages in longer-term storage used by cloud DVR services, but with an additional complication in private-use scenarios. Here, the video quality monitoring system must be responsive to content flows into storage as they are triggered by individual users executing their cloud DVR options.
Moreover, the use of DAI on streams from storage adds another aspect to the time-shifted video monitoring requirements. The points of potential failure in the complex DAI processes employed within streamed services complicate service providers' efforts to confirm compliance with ad commitments.
Advances in Time-Shifted Video Monitoring
Technology has advanced in response to the new quality management challenges raised as more consumers choose to view time-shifted content. by the recent time shifted viewing strategies. Modern video quality monitoring and analytics solutions are now available that enable providers to ensure viewers' quality of experience and fully capitalize on time-shifted viewing.
Providers can deploy these solutions on-premises or in the cloud depending on the needs of their workflow. They can correlate test results into a concise report from any number of monitoring points required to meet content scale or visibility needs throughout the distribution network.
The objective of these solutions is to validate that each asset is ready to be streamed by a user in the most efficient way possible given the priority of the content. This validation requires analysis across multiple dimensions of streaming platform from contribution link, encoding, packaging, origin servers, CDNs, and final delivery to the subscribers.
Leveraging these solutions, service providers can support preemptive action against problems that might occur with playout from storage through an automated testing and reporting system that can be used to validate content readiness before customers start streaming.
Next-gen quality monitoring solutions can give operators the confidence they need to be as aggressive as they choose in delivering the convenience of time-shifted viewing to their customers. Whatever approaches they take, they know they can proceed with adherence to the highest quality standards.
Joel Daly is Vice President of Product Management at Telestream. He has worked in the data, voice and video communications industry for two decades. Prior to Telestream he held leadership product management and marketing roles at BTI Systems, BigBand Networks, 3Com, Sycamore Networks and Lucent Technologies.
You can learn more about advanced video quality monitoring of VOD and time-shifted viewing here.
[Editor's note: This is a contributed article from Telestream. Streaming Media accepts vendor bylines based solely on their value to our readers.]
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We appreciate your interest in a Sears franchise. One of our representatives will be in touch with you shortly.
Sears Carpet & Upholstery Cleaning services provide homeowners with deep carpet cleaning, as well as carpet stain treatment and removal.
Sears Carpet & Upholstery Cleaning services offer homeowners hardwood floor cleaning and revitalization as an alternative to restoring or reflooring.
Sears Carpet & Upholstery Cleaning services cover cleaning, deodorizing, and stain removal for all types of furniture throughout the home.
Sears Carpet & Upholstery Cleaning services provide a full range of services related to cleaning, coloring, sealing, or restoring grout throughout the home.
Sears Carpet & Upholstery Cleaning services are available to assist with water damage from emergencies throughout the home.
Check out the above video to learn about how you can become a Sears Franchise owner.


Abuja (Sundiata Post) – Senate President Bukola Saraki has been invited by the Nigeria Police force in connection with the bank robbery, which recently occurred, in Offa, Kwara State.
The Force Spokesperson, Jimoh Moshood, in a statement on Sunday, said the bank robbery led to the death of 33 persons including some pregnant women and nine police officers.
"The Senate President, Sen. Bukola Saraki is being invited by the Nigeria Police Force to report to the Force Intelligence Response Team office at Guzape, Abuja to answer to the allegations leveled against him from the confessions of the Five (5) Gang Leaders and some of the other 17 suspects arrested for direct involvement and active participation in the Offa Bank Robbery and the gruesome killing of 33 innocent persons which includes some pregnant women and nine Police personnel," Jimoh said in a statement.
Also according to the police, the five gang leaders further confessed that they are political thugs under the name; "Youth Liberation Movement" a.k.a "Good Boys" and were sponsored with firearms, money and operational vehicles by the Senate President Saraki and Governor Ahmed.
Recall that Saraki had earlier raised an alarm over an alleged plot by the Inspector General of Police (IGP) Ibrahim Idris to implicate him and the Kwara State Governor Abdulfatai Ahmed.


A free course to help you manage difficult situations like anxiety and depression.
This is a group course. It's very informal and held in a calm, friendly and welcoming atmosphere. The aim of the course is to teach you how to overcome or cope with particular personal difficulties.
Do ice-breaker exercises, so you won't have to tell everyone your name, find out about the person sitting next to you or say something interesting about yourself.
Ask people to share their experiences. While we welcome people sharing and try to encourage discussion, no-one will be forced to participate or say anything.
Do group therapy. These are psycho-educational courses, so our aim is to teach people how to overcome or cope with particular emotional difficulties.
Respect that everyone will be attending for different reasons and will have their own knowledge and experiences and we ask that people show that same respect to others.
Acknowledge that coming to these courses can be difficult. For many people. This will be their first experience of anything like this. At the start of each course we go through group guidelines to alleviate some of the fears people might have.
Try our best to answer any questions you may have and if we cannot, then we will try to find out the following session, but we hope that the course content will answer many questions that people have.
Encourage people to try some of the things we suggest on the courses at home, as this enables people to try things and then address any difficulties at the next session. But this is not compulsory and we won't ask anyone why they didn't try something as we recognise that not all the techniques will be suitable for everyone.
Problems with stress are incredibly common. This session looks at what stress is and how it can affect people differently, placing particular emphasis on the two main problems of stress; anxiety and depression. The first class also introduces CBT (Cognitive Behavioural Therapy), the theory that how feeling bad, thinking negatively, and unhelpful behaviour all connect to form a vicious cycle leading to stress.
Anxiety and low mood has a huge impact upon us physically. This session looks at the effect that stress, anxiety and the depression have on the body and teaches some strategies to reduce and cope with these often distressing symptoms.
How we think about ourselves and our lives has a massive effect on how we feel. This session uses cognitive techniques from CBT to look at balancing and changing the way we think about things.
What we feel and how we think often leads to us behaving in certain ways. This final session looks at positive actions that can reduce stress, looking at further interventions for breaking the vicious cycle of feeling bad, negative thinking and unhelpful behaviours.


Are you bound for the Beijing Olympics?
With many tickets and packages already sold out, the window for booking an affordable trip to the summer Olympics is drawing to a close. We want to know: Are you or any of your friends or family traveling to Beijing for the Olympics? If not, has the increased attention inspired you to consider a future visit?
Post a comment below and check out our Beijing 2008 Olympics Guide for practical advice, photos of new attractions, and uncut video.


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New process harvests hydrogen from plant waste at record speeds
By Ryan Whitwam on April 10, 2015 at 3:50 pm
Hydrogen makes for an excellent energy source for both combustion and fuel cells, but figuring out where to get it is an unexpectedly complicated question. Hydrogen is literally the most common element in the known universe, yet most of the pure hydrogen we have comes from fossil fuels. A team of scientists at Virginia Tech think they've come up with a better way — by processing plant waste in an innovative fashion.
Traditionally, it you need a lot of hydrogen, you just go where the hydrogen is. Fossil fuels (like natural gas) are hydrocarbons, and that means you can harvest hydrogen atoms by stripping them off the carbon backbone. That rather defeats the idea of clean energy from hydrogen, though. What about water? That's oxygen and hydrogen, but it takes a lot of energy to break the hydrogen atoms free. Solar power can be used to split water, but it's very slow. Electrolysis of water is faster, but it's inefficient — it consumes more power than you get from the hydrogen, in fact.
The Virginia Tech process uses an enzymatic process that pulls hydrogen out of leftover stalks, cobs, and husks of corn. These inedible parts of the corn plant are collectively referred to as stover. After we take the tasty bits off of a plant like corn, there's still a lot of material left. One of the main structural components of a plant is cellulose, which is a polysaccharide consisting of hundreds or thousands of linked glucose molecules. There's a lot of energy in that molecule, and plenty of hydrogen atoms to be harvested (10 of them per glucose molecule). The process also converts another sugar in plants called xylose for even faster hydrogen production.
The team used a genetic algorithm and a lot of math to come up with the precise enzymatic process that could efficiently pull the hydrogen out of this waste material. This is what sets the Virginia Tech process apart, in fact. Enzymatic processes have been used to generate hydrogen from sugars before, but they only worked with refined and processed materials. This one works on the junk left over from corn farming, and the overall reaction rate is three times faster than old enzymatic methods, and more than 10 times faster than solar-powered hydrogen production from water.
The only issue with this process is that it results in the release of carbon dioxide in addition to hydrogen. Since this is plant biomass, that still counts as carbon neutral. Still, it might be nice to capture that gas for sequestration, rather than add to the problem. The study was performed on small volumes of biomass, but the team thinks the same process can be scaled up with a little work. They say it might even be able to help hydrogen displace fossil fuels. That might take a while, but it's not like we're going to run out of leftover plant matter in the meantime.


Please note that this calculator is only intended for sole proprietors (or LLCs taxed as such). If your business is an S-corp, C-corp, or LLC taxed as such, please consult with your tax professional.
Do you have earnings from another job (i.e., a "day job")?
A catch-up contribution of .
Where Did This Answer Come From?
A catch-up contribution of for if you are 50 or older.
In this case, your net earnings from self-employment is defined as your business's profit (), minus the deduction for one half of your self-employment tax ().
However, there are an assortment of limitations to the above contributions.
If you have another job (i.e., a "day job"), your maximum employee contribution is reduced by any contributions you made as an employee to another 401(k) or 403(b). Ditto for catch-up contributions.
The employer contribution is limited to half of the difference between your net earnings from self-employment and the employee contribution.
The employee and employer contributions are limited to a combined total of for .
Various amounts in this explanation may be off slightly due to rounding of cents.
Solo 401(k) plans are complicated, so it's likely a good idea to consult with your tax professional.


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Home > Business > India's agricultural & processed food products exports up 31 pc to USD 7408 Million in Q1FY23
India's agricultural & processed food products exports up 31 pc to USD 7408 Million in Q1FY23
NEW DELHI, AUGUST 6, 2022
Continuing with the trend from the previous year, the exports of agricultural and processed food products rose by 31 percent in the first three months of the current Financial Year 2022-23 (April-June) in comparison to the corresponding period of FY 2021-22.
According to the provisional data released by the Directorate General of Commercial Intelligence and Statistics (DGCI&S), the overall export of APEDA products increased to USD 7408 million in April-June 2022 from USD 5663 million over the same period of the last fiscal. The export target for April-June 2022-23 was fixed at USD 5890 million.
The initiatives taken by the Agricultural and Processed Food Products Export Development Authority (APEDA) that works under the Ministry of Commerce and Industry have helped the country in achieving 31 percent of the total export target in the first quarter of the current fiscal.
For the year 2022-23, an export target of USD 23.56 billion has been fixed by APEDA for the agricultural and processed food products basket.
As per the DGCI&S provisional data, fresh fruits & vegetables registered four percent growth, while processed fruits and vegetables recorded a significant growth of 59.71 percent (April-June 2022) in comparison to corresponding months of the previous year.
Also, processed food products like cereals and miscellaneous processed items reported a growth of 37.66 percent in comparison to the first quarter of the previous year.
In April-June, 2021, fresh fruits and vegetables were exported to the tune of USD 394 million that increased to USD 409 million in the corresponding months of the current fiscal. Exports of processed F&V jumped to USD 490 million in Q1 of the current fiscal from USD 307 million in the corresponding months of the previous year.
Basmati Rice exports witnessed a growth of 25.54 percent in the first three months of FY 2022-23 as its export increased from USD 922 million (April-June 2021) to USD 1157 million (April-June 2022), while the export of non-Basmati rice registered a growth of 5 percent in Q1 of current fiscal. Non-basmati rice export increased to USD 1566 million in the first three months of the current fiscal from USD 1491 million in the corresponding months of the previous year.
The export of meat, dairy & poultry products increased by 9.5 percent and the export of other cereals recorded a growth of 29 percent in Q1 of the current fiscal. The dairy products alone recorded a growth of 67.15 percent as its export rose to USD 191 million in the first three months of the current fiscal from USD 114 million in corresponding months of the previous year.
Other cereals' export increased from USD 237 million in April-June 2021to USD 306 million in April-June 2022 and the export of livestock products increased from USD 1022 million in April-June 2021 to USD 1120 million in April-June 2022.
"We continue to provide technical and financial assistance to various stakeholders in the agricultural goods value chains for boosting exports of unique products from the country," Dr. M. Angamuthu, Chairman, APEDA, said.
As per the DGCI&S data, the country's agricultural products exports had grown by 19.92 per cent during 2021-22 to touch USD 50.21 billion. The growth rate is significant as it is over and above the growth of 17.66 per cent at USD 41.87 billion achieved in 2020-21 and has been achieved in spite of unprecedented logistical challenges in the form of high freight rates and container shortages, etc.
APEDA had scripted a new history by exporting agricultural and processed food products to the tune of USD 25.6 billion in 2021-22, which was around 51 per cent of India's total agricultural goods exports of more than USD 50 billion.
"Through creating a necessary eco-system of exports along with collaboration with key stakeholders in the agri-exports value chains, we are aiming to sustain the growth in India's agricultural and processed food exports in the current fiscal as well," Angamuthu, said.
The rise in the export of agricultural and processed food products is the outcome of APEDA's various initiatives taken for the export promotion of agricultural and processed food products such as organising B2B exhibitions in different countries, exploring new potential markets through product-specific and general marketing campaigns by the active involvement of Indian Embassies.
The APEDA has also taken several initiatives to promote products having registered geographical indications (GI) in India by organising virtual Buyer Seller Meets on agricultural and food products with the United Arab Emirates and on GI products, including handicrafts with the USA.
In a bid to give a boost to the export of Indian wine, the APEDA facilitated participation of 10 wine exporters in the London Wine Fair held between June 7- 9, 2022.
APEDA recently organized a conference on the boosting export potential of natural, organic and GI-agro Products from the north-eastern states in Guwahati, Assam. The objective of the conference is to promote the export of natural, organic and GI agro-products grown in Assam and neighbouring states by creating international market linkages.
In collaboration with the Union Territory of Ladakh, APEDA recently organized an International Buyer Seller Meet, which aimed at boosting exports of Apricots and other agri-products from Ladakh. Eighteen entrepreneurs from UTs of Ladakh and Jammu and Kashmir displayed a range of Apricots and other Agri Products. Twenty buyers from India, USA, Bangladesh, Oman, Dubai participated in this event.
APEDA launched an eight-day-long Mango Festival in the Kingdom of Bahrain on June 13. At the show, 34 varieties of mangoes from eastern states, including West Bengal, Bihar, Jharkhand, and Odisha, were displayed at Bahrain's Al Jazira group supermarket.
The mango show in Bahrain is part of APEDA's new initiatives to explore international markets for Indian mangoes under the 'Mango Festival 2022'. It's the outcome of APEDA's commitment to provide a global platform for Indian mangoes that for the time 34 varieties of mangoes from eastern states have been showcased in Bahrain. On earlier occasions, mango varieties from Southern states like Alphonso, Kesar, Banganpalli, etc were showcased in most of the global shows.
In order to ensure seamless quality certification of products to be exported, APEDA has recognised 220 labs across India to provide services of testing to a wide range of products and exporters.
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Running a fund restructuring can be virgin territory for GPs; ILPA's latest guidelines will be as helpful to them as it will to its members.
The Institutional Limited Partners Association's guidance defines status quo options, minimum timeframes for LP decisions and recommends caps on deal expenses.
Secondaries Investor caught up with the industry body's chief executive Steven Nelson for a sneak peek at its soon-to-be released GP-led secondaries best practices.
At a secondaries-themed breakfast we found that, unlike the pastries, changes to US tax rules are not going down well.
Holding tax on effectively connected income has significantly increased the time taken to execute deals, according to intermediary Elm Capital.
Expect a document that gets into the weeds when the LP body issues its best practices for fund restructurings.
The industry body, which represents $2trn in PE assets, plans to publish an update to its private equity principles as early as this year.
The Trump-appointee fills a position vacated by Michael Piwowar in July.
The secondaries market has come a long way; best practice around managing conflicts of interest has some way to go.
The SEC alleges the firm withheld information on an updated net asset value for stakes in its Fund III before a sale.


Apple has released two new videos showing how Apple Watch users can enable health-related Apple Watch features that include fall detection and heart health notifications.
Shared on Thursday, Apple has added to its Apple Watch how-to series with two quick step-by-step videos detailing how to turn on fall detection and heart health notifications in the Apple Watch app on the iPhone.
Fall detection is a feature that is enabled by default for those who are over 65, but younger Apple Watch Series 4 users must enable it manually. The system uses the gyroscope and the accelerometer built into the Apple Watch to detect a fall, and then it contacts emergency services to alert them of the apparent trip or fall.
Heart health notifications let users know when their heart rate is too low, too high, or if an irregular rhythm that looks like atrial fibrillation is detected.
Apple has shared a range of insightful how-to videos to its Apple Watch tutorial series so far, walking watch owners through the features available on the Apple Watch Series 4 including watch face customization, Walkie-Talkie, Activity rings, customizing workout metrics, locating an iPhone from Apple Watch, and streaming Apple Music.


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 Here you can find or stalk strangers.

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We sail along the coast of Samaná with the wind blowing through our hair and our eyes filled with the peninsula's natural attractions, go for a fabulous snorkelling session and relax on a heavenly beach: all the marvels of the Caribbean in a single excursion!
We board a comfortable catamaran and set off on our excursion through the crystal-clear waters of the Samaná bay.
With the sweet breeze of the Caribbean caressing our cheeks, we enjoy beautiful views of the coast where large bays and small inlets alternate overlooked by the deep green of the lush tropical vegetation.
We stop over at Punta Lirio to cool down and enjoy some excellent local fruit.
We then drop anchor at Cayo Farola, famous for its diverse colourful fauna. We dive into the waters to enjoy an unforgettable snorkelling session: explore the sea bed and observe colourful tropical fish and coral.
After the dive, we get back on board and sail to Cayo Levantado, an enchanting islet with sandy beaches in the shade of coconut trees. We can relax on the sand.


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Canadian Prime Minister Seeks to Legalize Assisted Suicide
by Katie Daniels
On April 14, the Canadian Prime Minister, Justin Trudeau, introduced new legislation that would legalize doctor-assisted suicide for citizens suffering from "serious and incurable illness" which has caused them "physical or psychological suffering."
The Roman Catholic Archbishop of Toronto, Cardinal Thomas Collins, used Trudeau's new legislation as an occasion to reaffirm the Catholic Church's staunch opposition to any form of assisted death. "It changes our approach to human life, it changes our approach to human society," Cardinal Collins said in an interview.
In a nod to Switzerland's rise in "medical tourism," Canada's law would limit doctor-assisted suicide to Canadian citizens and residents eligible for the national health care system. The country wants to avoid dying people from other countries crossing the border for the procedure, a common practice in Switzerland, where doctor-assisted suicide has been legal since 1940.
Under Trudeau's proposed law, doctors or nurse practitioners can administer death-inducing medication to consenting adults who have serious medical conditions and are "capable of making decisions with respect to their health." A doctor must also decide that "natural death has become reasonably foreseeable." Social workers and pharmacists, as well as family and friends, are all legally allowed to assist patients with the process.
"For some, medical assistance in dying will be troubling," the Canadian justice minister Jody Wilson-Raybould said at a news conference. "For others, this legislation will not go far enough."
Trudeau's proposal does include some restrictions. For example, it contains no provisions for minors to choose to end their lives, nor does it allow people in early stages of dementia to request assisted suicide while they are still competent. Before ending his or her life, the patient must wait 15 days after receiving approval from two different doctors. Physicians are not required by law to help people die. However, if a doctor objects to participating, they are required to refer their patient to a new doctor.
Dr. Brett Belchetz, a doctor with the advocacy group Dying With Dignity Canada, argued that, "This law actually pits me against medical ethics. There are a number of shortfalls and I do think the legislation requires an urgent rethink."
The Archbishop of Ottawa, Terrence Prendergast, also commented on the moral implications of assisted suicide. "From not only a Catholic perspective but any rational perspective, the intentional, willful act of killing oneself or another human being is clearly morally wrong." He cited the Catechism of the Catholic Church, which says that, "Whatever its motives and means, direct euthanasia consists in putting an end to the lives of handicapped, sick or dying persons. It is morally unacceptable."
Prime Minister Trudeau had supported a law that would allow for doctor-assisted deaths before he became prime minister. He says his position is informed by the final days of his father's life. Trudeau's father and a former prime minister of Canada, Pierre Elliott Trudeau died in 2000 after he declined treatment for advanced prostate cancer and Parkinson's disease.
tagPlaceholderTags: World, Daniels, Apr2016