text:
Facing Trump's threats, why in God's name would North Korea disarm?
There's the blustering tyrant — and then there's Kim Jong-un. He has no earthly reason to give up those nukes now
By Danielle Ryan
Published September 24, 2017 6:00AM (EDT)
(Getty/Spencer Platt)
President Donald Trump's speech to the United Nations General Assembly this past week did not put worried minds at ease.
What began as a factually sketchy boast about his own domestic accomplishments quickly devolved into the moment an American president stood up at the UN — a forum dedicated to dialogue and diplomacy — and threatened to wipe another nation off the map.
There's been a lot of discussion about the North Korea threat in recent months, but Trump's speech should prompt an uncomfortable question: Why would a nation like North Korea agree, voluntarily, to make itself defenseless against the United States?
North Korea is clearly a brutal and repressive regime, forcing its citizens to live in a society closed off to the rest of the world. Unfortunately there's no good or easy way to change that. It is also a highly militarized regime and not one likely to back down easily.
From Pyongyang's perspective, North Korea needs a nuclear deterrent to ward off potential attacks from the U.S. — and when Trump stands at the UN podium and threatens to "totally destroy" the entire country, Kim Jong-un can only feel vindicated in this regard.
Trump seems to see the issue in simplified terms: Do what we say and denuclearize or we'll destroy you. He told world leaders that "denuclearization is [North Korea's] only acceptable future."
Kim likely sees it very differently: If we are stupid enough to disarm, it will be easier for you to invade and destroy my regime, so why would I be so foolish? As long as he can threaten the U.S. with nukes, Kim feels relatively safe as the supreme leader of the hermit kingdom.
Similar rhetoric from Trump on Iran gives Kim further reason to defy Washington. When Trump accuses Tehran of not being in compliance with the nuclear deal signed in 2015 — despite the assurances of a UN watchdog which says that it is — the message sent is that deals made with the U.S. don't matter. If America won't abide by them, why should anyone else? In fact, why enter into one at all? That's the message being sent to the world by the great deal-maker.
Trump's base and his fans in the media loved the UN speech with all its bombastic rhetoric and name-calling. But how does Trump think his speech played in North Korea? North Koreans already believe their country is under imminent threat from the United States. Watching him threatening their country with nuclear annihilation will only strengthen anti-American sentiment.
In his speech, Trump spoke of a "small group of rogue regimes" and the "righteous many against the wicked few" — but it's important to remember how the U.S. is regarded around the world, not just by its allies. A 2013 survey conducted by Gallup International/WIN found that the U.S. is considered to be the greatest threat to peace in the world. Nearly one-quarter of respondents (24 percent) chose the U.S. when asked which country they considered the greatest threat. The closest runners up, Pakistan (8 percent) and China (6 percent), weren't even close.
Media coverage of the North Korea situation often promotes the idea that a deranged madman wants to blow up the world out of blind amusement. Fears are drummed up by sensationalist coverage, but more often than not, the leaders of despotic regimes like North Korea do not want to be at war — especially a war with the United States. Of course they want the world to be scared of them; they want to look big and strong and willing to use their military arsenal. But ultimately, war is a threat to their power and way of life. For them, in an ideal world, everything would just stay exactly as it is.
What also gets lost in the coverage of North Korea is history. There is a bloody history between the United States and North Korea that rarely gets a mention. The U.S. carpet-bombed North Korea for three years during the Korean War of the 1950s. It was done "with next to no concern for civilian casualties," according to Bruce Cummings, chairman of the history department at the University of Chicago and historian of the Korean conflict. Up to 3 million people were killed — about 20 percent of the population. As Gen. Curtis LeMay, head of the Strategic Air Command, put it: "We went over there and fought the war and eventually burned down every town in North Korea."
That's not a small event to drop into the memory hole when we're wondering why North Korea "hates" the U.S. It is not just a matter of propaganda — though that exists in abundance, too.
There's a similarly dark history between the U.S. and Iran — from the CIA-backed overthrow of Iran's democratically elected prime minister in 1953 to the time the U.S. military shot down an Iranian passenger jet in Iranian airspace, killing nearly 300 people, and refused to apologize — and then rewarded the commander responsible with a medal. There's always more to the story than "they hate us for our freedom."
According to one French expert, Kim Jong-un is dangerous, but not crazy. "The ruling Kim family is far from crazy. In truth, they are all perfectly rational and well-educated," she said. In her read of the situation, Trump is the irrational one — and that might be even scarier.
The North Korean leadership is hardly blameless in exacerbating this potential confrontation, but Trump's speech at the UN was highly provocative and unnecessary.
The excuse of the irrational madman leaving the righteous invader "no choice" is nothing new. It's blatant propaganda and we shouldn't be duped into supporting Trump as he weighs whether to march into a war that could imperil millions.
Danielle Ryan is an Irish freelance journalist, writing mostly on geopolitics and media. She is based in Budapest, but has also lived in the U.S., Germany and Russia. Follow her on Twitter.
MORE FROM Danielle Ryan
Donald Trump Iran Iran Deal Iran Nuclear Deal Kim Jong-un North Korea Nuclear Bomb Nuclear Weapons Trump Un Speech


text:
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sap.ui.define([
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		    $(".loader-text").fadeOut();
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redpajama_set_name: RedPajamaGithub


text:
(PE) Physical Sciences & Engineering (33) Apply (PE) Physical Sciences & Engineering filter
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Displaying 1 - 10 of 38. Show 10 | 20 results per page.
Project acronym ANGIOFAT
Project New mechanisms of angiogenesis modulators in switching between white and brown adipose tissues
Researcher (PI) Yihai Cao
Host Institution (HI) KAROLINSKA INSTITUTET
Call Details Advanced Grant (AdG), LS4, ERC-2009-AdG
Summary Understanding the molecular mechanisms underlying adipose blood vessel growth or regression opens new fundamentally insight into novel therapeutic options for the treatment of obesity and its related metabolic diseases such as type 2 diabetes and cancer. Unlike any other tissues in the body, the adipose tissue constantly experiences expansion and shrinkage throughout the adult life. Adipocytes in the white adipose tissue have the ability to switch into metabolically highly active brown-like adipocytes. Brown adipose tissue (BAT) contains significantly higher numbers of microvessels than white adipose tissue (WAT) in order to adopt the high rates of metabolism. Thus, an angiogenic phenotype has to be switched on during the transition from WAT into BAT. We have found that acclimation of mice in cold could induce transition from inguinal and epidedymal WAT into BAT by upregulation of angiogenic factor expression and down-regulations of angiogenesis inhibitors (Xue et al, Cell Metabolism, 2009). The transition from WAT into BAT is dependent on vascular endothelial growth factor (VEGF) that primarily targets on vascular endothelial cells via a tissue hypoxia-independent mechanism. VEGF blockade significantly alters adipose tissue metabolism. In another genetic model, we show similar findings that angiogenesis is crucial to mediate the transition from WAT into BAT (Xue et al, PNAS, 2008). Here we propose that the vascular tone determines the metabolic switch between WAT and BAT. Characterization of these novel angiogenic pathways may reveal new mechanisms underlying development of obesity- and metabolism-related disease complications and may define novel therapeutic targets. Thus, the benefit of this research proposal is enormous and is aimed to treat the most common and highly risk human health conditions in the modern time.
Understanding the molecular mechanisms underlying adipose blood vessel growth or regression opens new fundamentally insight into novel therapeutic options for the treatment of obesity and its related metabolic diseases such as type 2 diabetes and cancer. Unlike any other tissues in the body, the adipose tissue constantly experiences expansion and shrinkage throughout the adult life. Adipocytes in the white adipose tissue have the ability to switch into metabolically highly active brown-like adipocytes. Brown adipose tissue (BAT) contains significantly higher numbers of microvessels than white adipose tissue (WAT) in order to adopt the high rates of metabolism. Thus, an angiogenic phenotype has to be switched on during the transition from WAT into BAT. We have found that acclimation of mice in cold could induce transition from inguinal and epidedymal WAT into BAT by upregulation of angiogenic factor expression and down-regulations of angiogenesis inhibitors (Xue et al, Cell Metabolism, 2009). The transition from WAT into BAT is dependent on vascular endothelial growth factor (VEGF) that primarily targets on vascular endothelial cells via a tissue hypoxia-independent mechanism. VEGF blockade significantly alters adipose tissue metabolism. In another genetic model, we show similar findings that angiogenesis is crucial to mediate the transition from WAT into BAT (Xue et al, PNAS, 2008). Here we propose that the vascular tone determines the metabolic switch between WAT and BAT. Characterization of these novel angiogenic pathways may reveal new mechanisms underlying development of obesity- and metabolism-related disease complications and may define novel therapeutic targets. Thus, the benefit of this research proposal is enormous and is aimed to treat the most common and highly risk human health conditions in the modern time.
Max ERC Funding
Start date: 2010-03-01, End date: 2015-02-28
Project acronym ASD
Project Atomistic Spin-Dynamics; Methodology and Applications
Researcher (PI) Olof Ragnar Eriksson
Host Institution (HI) UPPSALA UNIVERSITET
Call Details Advanced Grant (AdG), PE3, ERC-2009-AdG
Summary Our aim is to provide a theoretical framework for studies of dynamical aspects of magnetic materials and magnetisation reversal, which has potential for applications for magnetic data storage and magnetic memory devices. The project focuses on developing and using an atomistic spin dynamics simulation method. Our goal is to identify novel materials and device geometries with improved performance. The scientific questions which will be addressed concern the understanding of the fundamental temporal limit of magnetisation switching and reversal, and the mechanisms which govern this limit. The methodological developments concern the ability to, from first principles theory, calculate the interatomic exchange parameters of materials in general, in particular for correlated electron materials, via the use of dynamical mean-field theory. The theoretical development also involves an atomistic spin dynamics simulation method, which once it has been established, will be released as a public software package. The proposed theoretical research will be intimately connected to world-leading experimental efforts, especially in Europe where a leading activity in experimental studies of magnetisation dynamics has been established. The ambition with this project is to become world-leading in the theory of simulating spin-dynamics phenomena, and to promote education and training of young researchers. To achieve our goals we will build up an open and lively environment, where the advances in the theoretical knowledge of spin-dynamics phenomena will be used to address important questions in information technology. In this environment the next generation research leaders will be fostered and trained, thus ensuring that the society of tomorrow is equipped with the scientific competence to tackle the challenges of our future.
Our aim is to provide a theoretical framework for studies of dynamical aspects of magnetic materials and magnetisation reversal, which has potential for applications for magnetic data storage and magnetic memory devices. The project focuses on developing and using an atomistic spin dynamics simulation method. Our goal is to identify novel materials and device geometries with improved performance. The scientific questions which will be addressed concern the understanding of the fundamental temporal limit of magnetisation switching and reversal, and the mechanisms which govern this limit. The methodological developments concern the ability to, from first principles theory, calculate the interatomic exchange parameters of materials in general, in particular for correlated electron materials, via the use of dynamical mean-field theory. The theoretical development also involves an atomistic spin dynamics simulation method, which once it has been established, will be released as a public software package. The proposed theoretical research will be intimately connected to world-leading experimental efforts, especially in Europe where a leading activity in experimental studies of magnetisation dynamics has been established. The ambition with this project is to become world-leading in the theory of simulating spin-dynamics phenomena, and to promote education and training of young researchers. To achieve our goals we will build up an open and lively environment, where the advances in the theoretical knowledge of spin-dynamics phenomena will be used to address important questions in information technology. In this environment the next generation research leaders will be fostered and trained, thus ensuring that the society of tomorrow is equipped with the scientific competence to tackle the challenges of our future.
Project acronym BBBARRIER
Project Mechanisms of regulation of the blood-brain barrier; towards opening and closing the barrier on demand
Researcher (PI) Bjoern Christer Betsholtz
Call Details Advanced Grant (AdG), LS4, ERC-2011-ADG_20110310
Summary In the bone-enclosed CNS, increased vascular permeability may cause life-threatening tissue swelling, and/or ischemia and inflammation which compromise tissue repair after trauma or stroke. The brain vasculature possesses several unique features collectively named the blood-brain barrier (BBB) in which passive permeability is almost completely abolished and replaced by a complex of specific transport mechanisms. The BBB is necessary to uphold the specific milieu necessary for neuronal function. Whereas breakdown of the BBB is part of many CNS diseases, including stroke, neuroinflammation, trauma and neurodegenerative disorders, its molecular mechanisms and consequences are unclear and debated. Conversely, the intact BBB is a huge obstacle for drug delivery to the brain. Research on the BBB therefore has two seemingly opposing aims: 1) to seal a damaged BBB and protect the brain from toxic blood products, and 2) to open the BBB "on demand" for drug delivery. A major problem in the BBB field has been the lack of in vivo animal models for molecular and functional studies. So far, available in vitro models are not recapitulating the in vivo BBB. Our recent work on mouse models lacking pericytes, a BBB-associated cell type, demonstrates a specific role for pericytes in the development and regulation of the mammalian BBB. These animal models are the first ones showing a general and significant BBB impairment in adulthood, and as such they provide a unique opportunity to address molecular mechanisms of BBB disruption in disease and in drug transport across the BBB. Importantly, the new models and tools that we have developed allow us to search for relevant druggable mechanisms and molecular targets in the BBB. The long-term goals of this proposal are to develop molecular strategies and tools to open and close the BBB "on demand" for drug delivery to the CNS, and to explore the importance and mechanisms of BBB dysfunction in neurodegenerative diseases and stroke.
In the bone-enclosed CNS, increased vascular permeability may cause life-threatening tissue swelling, and/or ischemia and inflammation which compromise tissue repair after trauma or stroke. The brain vasculature possesses several unique features collectively named the blood-brain barrier (BBB) in which passive permeability is almost completely abolished and replaced by a complex of specific transport mechanisms. The BBB is necessary to uphold the specific milieu necessary for neuronal function. Whereas breakdown of the BBB is part of many CNS diseases, including stroke, neuroinflammation, trauma and neurodegenerative disorders, its molecular mechanisms and consequences are unclear and debated. Conversely, the intact BBB is a huge obstacle for drug delivery to the brain. Research on the BBB therefore has two seemingly opposing aims: 1) to seal a damaged BBB and protect the brain from toxic blood products, and 2) to open the BBB "on demand" for drug delivery. A major problem in the BBB field has been the lack of in vivo animal models for molecular and functional studies. So far, available in vitro models are not recapitulating the in vivo BBB. Our recent work on mouse models lacking pericytes, a BBB-associated cell type, demonstrates a specific role for pericytes in the development and regulation of the mammalian BBB. These animal models are the first ones showing a general and significant BBB impairment in adulthood, and as such they provide a unique opportunity to address molecular mechanisms of BBB disruption in disease and in drug transport across the BBB. Importantly, the new models and tools that we have developed allow us to search for relevant druggable mechanisms and molecular targets in the BBB. The long-term goals of this proposal are to develop molecular strategies and tools to open and close the BBB "on demand" for drug delivery to the CNS, and to explore the importance and mechanisms of BBB dysfunction in neurodegenerative diseases and stroke.
Project acronym BETAIMAGE
Project An in vivo imaging approach to understand pancreatic beta-cell signal-transduction
Researcher (PI) Per-Olof Berggren
Summary The challenge in cell physiology/pathology today is to translate in vitro findings to the living organism. We have developed a unique approach where signal-transduction can be investigated in vivo non-invasively, longitudinally at single cell resolution, using the anterior chamber of the eye as a natural body window for imaging. We will use this approach to understand how the universally important and highly complex signal Ca2+ is regulated in the pancreatic beta-cell, while localized in the vascularized and innervated islet of Langerhans, and how that affects the insulin secretory machinery in vivo. Engrafted islets in the eye take on identical innervation- and vascularization patterns as those in the pancreas and are proficient in regulating glucose homeostasis in the animal. Since the pancreatic islet constitutes a micro-organ, this imaging approach offers a seminal model system to understand Ca2+ signaling in individual cells at the organ level in real life. We will test the hypothesis that the Ca2+-signal has a key role in pancreatic beta-cell function and survival in vivo and that perturbation in the Ca2+-signal serves as a common denominator for beta-cell pathology associated with impaired glucose homeostasis and diabetes. Of special interest is how innervation impacts on Ca2+-dynamics and the integration of autocrine, paracrine and endocrine signals in fine-tuning the Ca2+-signal with regard to beta-cell function and survival. We aim to define key defects in the machinery regulating Ca2+-dynamics in association with the autoimmune reaction, inflammation and obesity eventually resulting in diabetes. Our imaging platform will be applied to clarify in vivo regulation of Ca2+-dynamics in both healthy and diabetic human beta-cells. To define novel drugable targets for treatment of diabetes, it is crucial to identify similarities and differences in the molecular machinery regulating the in vivo Ca2+-signal in the human and in the rodent beta-cell.
The challenge in cell physiology/pathology today is to translate in vitro findings to the living organism. We have developed a unique approach where signal-transduction can be investigated in vivo non-invasively, longitudinally at single cell resolution, using the anterior chamber of the eye as a natural body window for imaging. We will use this approach to understand how the universally important and highly complex signal Ca2+ is regulated in the pancreatic beta-cell, while localized in the vascularized and innervated islet of Langerhans, and how that affects the insulin secretory machinery in vivo. Engrafted islets in the eye take on identical innervation- and vascularization patterns as those in the pancreas and are proficient in regulating glucose homeostasis in the animal. Since the pancreatic islet constitutes a micro-organ, this imaging approach offers a seminal model system to understand Ca2+ signaling in individual cells at the organ level in real life. We will test the hypothesis that the Ca2+-signal has a key role in pancreatic beta-cell function and survival in vivo and that perturbation in the Ca2+-signal serves as a common denominator for beta-cell pathology associated with impaired glucose homeostasis and diabetes. Of special interest is how innervation impacts on Ca2+-dynamics and the integration of autocrine, paracrine and endocrine signals in fine-tuning the Ca2+-signal with regard to beta-cell function and survival. We aim to define key defects in the machinery regulating Ca2+-dynamics in association with the autoimmune reaction, inflammation and obesity eventually resulting in diabetes. Our imaging platform will be applied to clarify in vivo regulation of Ca2+-dynamics in both healthy and diabetic human beta-cells. To define novel drugable targets for treatment of diabetes, it is crucial to identify similarities and differences in the molecular machinery regulating the in vivo Ca2+-signal in the human and in the rodent beta-cell.
Project acronym COMPASS
Project Colloids with complex interactions: from model atoms to colloidal recognition and bio-inspired self assembly
Researcher (PI) Peter Schurtenberger
Host Institution (HI) MAX IV Laboratory, Lund University
Summary Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature's strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of "colloidal molecules" with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the assembly to establish the requirements for the controlled formation of tubular shells and thus create a colloid-based minimal model of synthetic virus capsid proteins.
Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature's strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of "colloidal molecules" with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the assembly to establish the requirements for the controlled formation of tubular shells and thus create a colloid-based minimal model of synthetic virus capsid proteins.
Project acronym CUSTOMER
Project Customizable Embedded Real-Time Systems: Challenges and Key Techniques
Researcher (PI) Yi WANG
Summary Today, many industrial products are defined by software and therefore customizable: their functionalities implemented by software can be modified and extended by dynamic software updates on demand. This trend towards customizable products is rapidly expanding into all domains of IT, including Embedded Real-Time Systems (ERTS) deployed in Cyber-Physical Systems such as cars, medical devices etc. However, the current state-of-practice in safety-critical systems allows hardly any modifications once they are put in operation. The lack of techniques to preserve crucial safety conditions for customizable systems severely restricts the benefits of advances in software-defined systems engineering. CUSTOMER is to provide the missing paradigm and technology for building and updating ERTS after deployment – subject to stringent timing constraints, dynamic workloads, and limited resources on complex platforms. CUSTOMER explores research areas crossing two fields: Real-Time Computing and Formal Verification to develop the key techniques enabling (1) dynamic updates of ERTS in the field, (2) incremental updates over the products life time and (3) safe updates by verification to avoid updates that may compromise system safety. CUSTOMER will develop a unified model-based framework supported with tools for the design, modelling, verification, deployment and update of ERTS, aiming at advancing the research fields by establishing the missing scientific foundation for multiprocessor real-time computing and providing the next generation of design tools with significantly enhanced capability and scalability increased by orders of magnitude compared with state-of-the-art tools e.g. UPPAAL.
Today, many industrial products are defined by software and therefore customizable: their functionalities implemented by software can be modified and extended by dynamic software updates on demand. This trend towards customizable products is rapidly expanding into all domains of IT, including Embedded Real-Time Systems (ERTS) deployed in Cyber-Physical Systems such as cars, medical devices etc. However, the current state-of-practice in safety-critical systems allows hardly any modifications once they are put in operation. The lack of techniques to preserve crucial safety conditions for customizable systems severely restricts the benefits of advances in software-defined systems engineering. CUSTOMER is to provide the missing paradigm and technology for building and updating ERTS after deployment – subject to stringent timing constraints, dynamic workloads, and limited resources on complex platforms. CUSTOMER explores research areas crossing two fields: Real-Time Computing and Formal Verification to develop the key techniques enabling (1) dynamic updates of ERTS in the field, (2) incremental updates over the products life time and (3) safe updates by verification to avoid updates that may compromise system safety. CUSTOMER will develop a unified model-based framework supported with tools for the design, modelling, verification, deployment and update of ERTS, aiming at advancing the research fields by establishing the missing scientific foundation for multiprocessor real-time computing and providing the next generation of design tools with significantly enhanced capability and scalability increased by orders of magnitude compared with state-of-the-art tools e.g. UPPAAL.
Project acronym ECOSOCPOL
Project Social and Political Economics: Theory and Evidence
Researcher (PI) Torsten Persson
Host Institution (HI) STOCKHOLMS UNIVERSITET
Call Details Advanced Grant (AdG), SH1, ERC-2015-AdG
Summary In this project, I will study how individual and social motives interact to drive individual decisions, a question that has fallen between the cracks of different social-science approaches. I will use a common theoretical framework to approach an important, but badly understood, general question: do social motives reinforce or weaken the effect of changes in individual motives? By modifying this common framework to different applications, I will consider its predictions empirically in different large data sets with individual-level information. The planned applications include four subprojects in the social, political, and economic spheres: (i) decisions in China on the ethnicity of children in interethnic marriages and matching into such marriages, (ii) decisions on tax evasion in the U.K. and Sweden, (iii) decisions to give political campaign contributions in the U.S., and (iv) decisions about fertility in Sweden. I may also spell out the common lessons from the results on the interaction between individual and social motives in monograph format intended for a broader audience.
In this project, I will study how individual and social motives interact to drive individual decisions, a question that has fallen between the cracks of different social-science approaches. I will use a common theoretical framework to approach an important, but badly understood, general question: do social motives reinforce or weaken the effect of changes in individual motives? By modifying this common framework to different applications, I will consider its predictions empirically in different large data sets with individual-level information. The planned applications include four subprojects in the social, political, and economic spheres: (i) decisions in China on the ethnicity of children in interethnic marriages and matching into such marriages, (ii) decisions on tax evasion in the U.K. and Sweden, (iii) decisions to give political campaign contributions in the U.S., and (iv) decisions about fertility in Sweden. I may also spell out the common lessons from the results on the interaction between individual and social motives in monograph format intended for a broader audience.
Project acronym EYELETS
Project A regenerative medicine approach in diabetes.
Summary Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.
Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.
Project acronym GENCON
Project The evolutionary implications of genetic conflict
Researcher (PI) Goeran Arnqvist
Summary The study of genetic conflict is developing at an almost explosive rate. The recognition that genes or alleles residing in individuals of the two sexes may have conflicting interests is transforming evolutionary biology and, likewise, conflict between genes showing different modes of transmission may fundamentally affect adaptive evolution. The research proposed here will push the frontiers of genetic conflict research and establish new domains. It is aimed at exploring the novel possibility that conflict between mitochondrial and nuclear genes have far-reaching implications for adaptive evolution and at advancing our understanding of the biological consequences of sexual conflict. The project consists of several interrelated parts and will employ insects as model systems. First, I will assess to what extent genetic variation in fitness is sexually antagonistic and what life history traits contribute to sexually antagonistic variation. Second, I will elucidate the genomics of metabolic rate and measure selection on metabolic phenotypes. Third, I will test whether sexually antagonistic epistatic interactions between mitochondrial and nuclear genes generate conflict over metabolic rate. Fourth, I will test the hypothesis that sexual conflict contribute to the evolution of primary and secondary sexual traits. Fifth, I will shed light on the complicated evolutionary interplay between sexual conflict and mating system evolution. I will employ an innovative research strategy, 'experimental genomics', in which genomic data is used to guide experimental evolutionary work with distinct genotypes. The research outlined here will collectively provide an unprecedented wealth of information into the role of genetic conflict in several horizons of adaptive evolution, ranging from DNA sequence evolution over life history evolution to speciation, and will set the standard for a new generation of insightful studies aimed at bridging the gap between phenotypic selection and genomics.
The study of genetic conflict is developing at an almost explosive rate. The recognition that genes or alleles residing in individuals of the two sexes may have conflicting interests is transforming evolutionary biology and, likewise, conflict between genes showing different modes of transmission may fundamentally affect adaptive evolution. The research proposed here will push the frontiers of genetic conflict research and establish new domains. It is aimed at exploring the novel possibility that conflict between mitochondrial and nuclear genes have far-reaching implications for adaptive evolution and at advancing our understanding of the biological consequences of sexual conflict. The project consists of several interrelated parts and will employ insects as model systems. First, I will assess to what extent genetic variation in fitness is sexually antagonistic and what life history traits contribute to sexually antagonistic variation. Second, I will elucidate the genomics of metabolic rate and measure selection on metabolic phenotypes. Third, I will test whether sexually antagonistic epistatic interactions between mitochondrial and nuclear genes generate conflict over metabolic rate. Fourth, I will test the hypothesis that sexual conflict contribute to the evolution of primary and secondary sexual traits. Fifth, I will shed light on the complicated evolutionary interplay between sexual conflict and mating system evolution. I will employ an innovative research strategy, 'experimental genomics', in which genomic data is used to guide experimental evolutionary work with distinct genotypes. The research outlined here will collectively provide an unprecedented wealth of information into the role of genetic conflict in several horizons of adaptive evolution, ranging from DNA sequence evolution over life history evolution to speciation, and will set the standard for a new generation of insightful studies aimed at bridging the gap between phenotypic selection and genomics.
Project acronym GENE TARGET T2D
Project General and targeted approaches to unravel the molecular causes of type 2 diabetes
Researcher (PI) Leif Christer Groop
Summary Type 2 diabetes (T2D) affects worldwide at present about 250 million patients and an estimated 380 million in 2025. This epidemic has been ascribed to a collision between genes and an affluent society. Genetics of T2D has during recent years identified > 30 variants increasing susceptibility to T2D. Yet, these variants explain only 15% of the heritability of T2D. One reason could be that whole genome association studies can only detect common variants whereas identification of rare variants with stronger effects would require sequencing. A large part of this application is devoted to sequencing of affected family members from unique large pedigrees traced back to common ancestors around 1600. The advantage of using families is that identified variants can be tested for segregation with the trait. Genetic variants can influence expression of a gene in an allele specific manner. This will be explored by combining exome sequencing with sequencing of RNA from human islets. Impaired effects of the incretin hormones GLP-1 and GIP on the pancreatic islets represent central defects in T2D. Variants in the TCF7L2 and GIPR genes contribute to these defects. I will here explore the molecular mechanisms by which TCF7L2, the strongest T2D gene, causes T2D. GIP has unprecedented effects not only on islet function but also on body composition, blood flow and vascular complications in T2D. This application explores these effects and will test whether manipulation of GIP can mimic the normalization of glucose tolerance seen after gastric bypass surgery. Taken together, these general and targeted approaches are expected not only to provide new insights into the causes of T2D but also contribute with vital information for development of new treatments for T2D.
Type 2 diabetes (T2D) affects worldwide at present about 250 million patients and an estimated 380 million in 2025. This epidemic has been ascribed to a collision between genes and an affluent society. Genetics of T2D has during recent years identified > 30 variants increasing susceptibility to T2D. Yet, these variants explain only 15% of the heritability of T2D. One reason could be that whole genome association studies can only detect common variants whereas identification of rare variants with stronger effects would require sequencing. A large part of this application is devoted to sequencing of affected family members from unique large pedigrees traced back to common ancestors around 1600. The advantage of using families is that identified variants can be tested for segregation with the trait. Genetic variants can influence expression of a gene in an allele specific manner. This will be explored by combining exome sequencing with sequencing of RNA from human islets. Impaired effects of the incretin hormones GLP-1 and GIP on the pancreatic islets represent central defects in T2D. Variants in the TCF7L2 and GIPR genes contribute to these defects. I will here explore the molecular mechanisms by which TCF7L2, the strongest T2D gene, causes T2D. GIP has unprecedented effects not only on islet function but also on body composition, blood flow and vascular complications in T2D. This application explores these effects and will test whether manipulation of GIP can mimic the normalization of glucose tolerance seen after gastric bypass surgery. Taken together, these general and targeted approaches are expected not only to provide new insights into the causes of T2D but also contribute with vital information for development of new treatments for T2D.

redpajama_set_name: RedPajamaCommonCrawl


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Anshuman Bapna, chief product officer (new developments), MakeMyTrip.
MakeMyTrip is a digital-born company and we have had our business in the digital format for more than a decade now—the number of data points we have is simply astounding. We take a step-by-step approach to digital, starting with applying analytics but in a disciplined manner across the organization. The big data mindset, to me, is not only about how big the data is but obsessing about collecting each and every data point about your business. For instance, while you can do a lot of analytics by looking at which flight options a customer clicked, there is a lot of intelligence around the real estate we have in terms of the screen size and we have been able to do a lot by analysing the options that did not get clicked even though they were right up there. Furthermore, we applied machine learning to discover patterns in user behaviour that we earlier did not think to be important but that turned out to be potential drivers of transactions.
We are not digital natives but like teenagers learning to walk. To judge how digital an organization is, you can look at it in terms of culture, strategic orientation, capabilities, and talent and organization. I would think we are somewhere between six and seven today (on a scale of one to 10 in digital readiness). We are strategically aligned in terms of the direction that finance is taking and how consumers want to engage with financial services organizations. Customer behaviour is driving these things and the moment customer-centricity is at the cultural heart of the organization, I think the organization could be well past mid-point in digital. But we have a lot more to do such as collaborating more with start-ups and understanding what's new in the world and bringing it on for our customers.
Data-driven transformation is really happening. The world is beginning to realize there is so much of data available. Recently, for instance, we worked on data analytics for a healthcare delivery company in the US, which realized it was losing revenue; we worked on creating a data model for them to deal with the complexities of handling data, giving them insights from that data and thus helping them to curb revenue leakage. Also, when machine learning was used on the data, they were able to more accurately predict their revenues. There is also disruption in the services industry, where many things are repetitive in nature. We are able to use machine learning algorithms to be able to help drive efficiencies of our own people and reduce the cost of delivery while improving customer experience.
There is so much of hype; what boils down in the end often is pretty much the same thing that has been done over the years. For instance, sometime back I met the CEO of a large hospital who spoke about AI and when I asked him how AI would help in their business, the example he gave was of analytics. The point is, a lot of organizations are still troubled by the differentiation in technologies. I generally divide companies into two categories: organizations that are physical-asset heavy and those that are data-asset heavy. The idea on both these sides is: How do you sweat these assets? Is plain-Jane efficiency enough? Actually, not any more. Even if my asset is doing 80%, is it enough for me to do just 80% or can I do something to get more out of these assets in, say, non-peak hours? For a data-asset heavy company, the question would be, How do I get even more out of the millions of data points and deliver, say, an even better customer experience?


Matching Dragoons: Jonah Hex #74 "The Bloody Saga of Railroad Bill!"
Jonah Hex #74 "The Bloody Saga of Railroad Bill!"
"The Bloody Saga of Railroad Bill!"
Jonah Hex stands in front of the desk of Mr. Thorgson, the owner of a railroad. Thorgson is railing (hee hee) against William Clinton, a train robber, who has been unstoppable. Clinton rode with Quantrill and has learned how to get the locals on his side, helping him cover his tracks. Hex asks why the Pinkertons haven't been involved and Thorgson says that the railroad has hired Pinkerton Archibald Graphus, but he keeps coming up empty handed. Now Thorgson is hiring Hex using his own money in order not to antagonize Graphus.
A week later in the town of Franklin Forks, we find Graphus and eight of his men crouching on a rooftop on main street. They are staking out the bank on a tip that Clinton will be knocking over that bank today (Looks like Clinton robs more than just trains). Sure enough, Clinton and twelve of his men come riding into town. He leaves two men outside to hold the horses and the rest head into the bank. Once in the bank, Clinton notices an old man who is wearing Confederate medals. He asks the man if the medals are his and the old man affirms that he got them at Chickamauga and Vicksburg and says that Clinton is now taking all the money he has in the world.
Clinton tells him that he has never stolen from a fellow Reb and never will. Clinton pulls out a fat wad of bills and gives them to the Rebel Vet. A few minutes later Clinton and his men are leaving the bank and Graphus is getting ready to give the signal to open fire (they waited until the bank had been robbed so that the crooks would have their hands full and be unable to fire back) when the local choir practice adjourns and a bunch of women walk out into the street. Ignoring the danger to innocent civilians, Graphus orders his men to open fire and when the dust settles eight of Clinton's men are dead along with several choir members.
The bodies aren't even cooling in the street before Graphus and his men head out after Clinton & his gang. Clinton and his men split up, but Graphus is looking down from a hilltop and pulls out his Remington with the fancy new sight, takes aim and drops Bill Clinton's horse is mid stride. Clinton's men are long gone already and Graphus & his bunch soon have Clinton sitting atop a horse with a noose around his neck.
Just then, Jonah Hex rides up. Jonah starts telling Graphus that they can't hang Clinton without a trial and during the argument, Clinton manages to get to a knife in the back of his pants and cuts himself loose. He then buries the knife into the sternum of one of Graphus's men. Tossing aside the noose, Clinton spurs the horse onward and rides off.
Jonah takes off after but Graphus isn't fooled, he sees that these two are working together and he shoots Hex in the back. Clinton hears the shot and turns to see Hex laying in the dirt. Bill Clinton wheels his horse around and clutching the reins in his teeth and firing his rifle like a man possessed, he charges Graphus and his men, allowing Jonah to climb on the back of the horse and they both make their escape.
Shortly, Clinton & Hex arrive at a farmer's house. The farmer agrees to help Clinton and Hex because of how much he hates the railroads. Soon after, the two men are leaving in a borrowed buckboard. Clinton tells Jonah that he recognizes Hex and he is going to take Hex to Ma Clinton's place to get patched up. If they run into each other after that, Clinton will have to kill Hex.
As they travel along they are stopped by two Pinkertons searching for them. One of the Pinkerton's notices Jonah's boots and Clinton shoots both men using a two shot pistol hidden up his sleeve. Hours later they finally arrive at Ma Clinton's place.
While Clinton's mom & sister tend to Hex's wounds, Clinton talks to his men about how Graphus was waiting for them at Franklin Forks. Terry, one of the men, says that the town was clean when it cased it the previous night. Eventually everyone beds down for the night.
The cover had an interesting bit of art. The bullet holes show the splash page underneath. Too bad that there weren't actual holes in the cover, but that was reserved for the higher end books with the pure white paper. This is a throwback to the lettering last seen on Issue 70. I like a more dynamic/edgy cover like this, but I prefer the more 'playbill' style lettering.
Next Issue: Terry gets his, Graphus gets sloppy, Clinton has to make a decision, and Jonah realizes that life stinks.
One would think that gunning down innocent choir members would be considered a BAD thing. But I guess that is because we are supposed to feel that the Pinkertons are just as bad as the outlaws.
I haven't read this issue before, but it's pretty good.
Is it just my browser or is #74's entry repeated twice and #75 is absent?


text:
WWE Judgment Day 2000 (2000)
Judgment Day (2000) was the first annual Judgment Day PPV. It was presented by 3DO's Army Men: World War and took place on May 21, 2000 at the Freedom Hall in Louisville, Kentucky. The main event was an Iron Man match for the WWF Championship and featured Triple H facing The Rock with Shawn Michaels as the special guest referee. Featured matches on the undercard included a double tables match featuring D-Generation X (Road Dogg and X-Pac) defeating The Dudley Boyz (Bubba Ray and D-Von). The other featured match on the undercard was a Submission match for the WWF Intercontinental Championship between Chris Benoit and Chris Jericho, which Benoit won to retain the championship.
Dean Simon
Dean Malenko
Brian James
Michael Hickenbottom
Michael Shawn Hickenbottom
Sean Michael Waltman
Brian Girard James
Write a review for WWE Judgment Day 2000


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As your daycare business grows, you will need to hire employees that will help you in running the business. In addition, provide information about the various markets within your industry as well as any new products or developments that will benefit or threaten your daycare business. Okay, so we have considered all the requirements for. Family narrative essay too much homework for high schoolers, goal essay conclusion, business plan slide deck medical surgical nursing critical thinking for collaborative careers issues to write a paper online business continuity plan template for small business ideas division homework sheetsNetwork business plan tamil interpersonal interview essay sample first paragraph for cancer research paper. You can recycle your original paragraphs that outlined your vision for the center into the Business Introduction. Provide a reasonable estimate of your start-up costs and revenue projections.
A solid business plan is essential to understanding the market and attracting financing. Your state's licensing office should also be able to provide you with an overview of the licensing requirements applicable to you, which you should read carefully. Include what types of insurance policies you will take out and how you will manage the accounting. Your local municipal government office should be able to tell you what licenses you will need to obtain in order to run your child-care business. Perhaps the best way to start making this decision is to examine your motivations for going into the child-care business. A business plan isn't necessarily set in stone, however, and you can adjust it periodically as your business grows or your plans change.
We are very aware that we have got to lower our price so that we will be able to attract customers like never before as we seek to gain recognition as newbies. Kids built-in desk for homework new business plan with lowest investment medical spa business plan template what to write my college essay about free freight business plan pro euthanasia essaySteps to writing a descriptive essay template how to write an english research paper format sample of executive summary for a business plan setting up a restaurant business plan free a review of the literature concerning ethical leadership in organization importance of voting essay in kannada language business plan examples uk. After putting out an advert seeking the services of a competent daycare manager or employee and talking to neighbors and friends; you will need to screen each applicant and make sure they meet the criteria. Physiology essay questionsPhysiology essay questions elementary problem solving strategies how to write am essay. Outbreak of diseases One thing with running a daycare center is that if one child comes in with fever, catarrh or cold, then there is high possibility that other children in the daycare may get infected too; and this is not good for business at all. Outline Your Organization and Management Describe the legal structure you will choose for your business. Write a brief summary of your goals and include why you think starting a day care business is a good idea.
This is so because you might not be able to make the money required to pay salary from the business when you are just starting out. Running a successful daycare does not only rely on proper marketing and proper budget planning but also on having a well grounded and dedicated staff that will run and maintain the business. You must also cover your back legally just in case an accident happens or a child dies in your custody. The metamorphosis essay how to write the title of a book in essay sample budget for research proposal fun problem solving math problems write my essay 4 me professional sample business development strategy plan language essay ideas assignment of personal property into trust when writing a book title in an essay, introduction to chemistry problem solving workbook problem solving softwares abstract in research paper sample pdf ebsco research papers pdf words used in research papers. Set your drive geared towards the purpose you built the center in the first place. You will also describe how and when your daycare opens and closes every day. Also, include a and other financial plans.
Over and above, it is important to consider all the tangible and intangible cost of starting a daycare centre when conducting cost analysis for the business. The truth is that you can start with 2 or 3 employees if indeed you want to minimize your running cost. Whichever form you choose, you will want to understand how to properly set up your business. How Much Does it Cost to Open a Daycare Center? Depending on the country and city where you intend to start your daycare centre, you would have to spend more money if you want a decent facility. The legal requirements to operate a home-based child-care business are also generally less strict than those for a center-based child-care business. For example, if your childcare center is to be located in a residential area, explain how your center's location nearer to home will attract parents reluctant to put their kids in an unknown neighborhood.
Your business plan will define how much money you will need to start your daycare business, how you will earn that money, and how you will spend it. Discussing the present outlook and potential of your industry is important, because this is what most investors want to know. So, if you have scaled the hurdle of being in love with children, then starting your own day care business might be a smart business choice. If you have the funds, newspaper, radio, and television ads will probably give you the greatest exposure, but these advertising formats do not come cheaply. That is why we have got to primarily focus on these types of people. Apart from the fact that running a daycare business is very lucrative, there are still other reasons why setting up a daycare business is the right business idea for you as an entrepreneur or stay-at-home mom who is in search of a good business to invest your money and time.
Essay with quotes of the tell-tale heartEssay with quotes of the tell-tale heart. If you plan to operate your child-care business out of your home, then this step is already complete. However, you must not trust your employees. Estimate how long will it take you to break even. It makes it easier for you to raise the estimate of the start-up capital because you already know before hand the required start-up capital. Furthermore, there is no indication that the day care trade would plummet anytime soon based on the statistics of parents who work that is found by experts. Starting a Daycare Center — Sample Business Plan Template 1.
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This would cover the startup costs of books, arts and crafts supplies, and toys, along with the cost of securing the location and obtaining the proper permits and insurance. Creche Business Plan — Sustainability and Expansion Strategy Our plans of establishing Tiny Thoughts is basically to test — run the Day care trade. The cost of acquiring these items varies. Homework for elementary students research 5 year business plan samples assign wan port to switch ddwrt fish farming business plan samples medical clinic business plan presentation restaurant business plan vivek bindra holiday homework of class 6 how to write a good paper in college station , colleges without supplemental essays sample apa research paper references accuplacer essay pdf pope essay on criticism text how to write essay introduction youtube. Below are some of those challenges: a. That is why investors are beginning to leverage on the high demand for day care services, to establish even better ones.


Scooter - AltaVista's spider (robot).
Search Engine -	A program which acts like a library card catalog for the Internet. Search engines attempt to help a user isolate desired information or resources by searching for keywords that the user specifies. The method for finding this information is usually done by maintaining an index of Web resources that can be queried for the keywords or concepts entered by the user. The index can be built from specific resource lists or created by Web wanderers, robots, spiders, crawlers, and worms.
Slurp -	Search Engine HotBot have its robot (spyder) named Slurp.
Snail Mail -	Normal postal mail, where an actual physical letter or package is delivered. The term didn't exist until e-mail became so prevalent that there was a requirement to differentiate the two. Obviously, the term was invented by e-mail aficionados as a small barb directed at the relative slowness of physical transportation. Snailmail is sometimes spelled as two separate words, snail mail.
Sponsorships -	Sponsorship is the process of integrating an advertisers messages with Web content on an exclusive basis. Examples of this are transitions ads with "brought to you by" messages, consistent co-branding of a section of content with the advertiser's icon "sponsored by …".
Spyder - This is search engine robot. Every time you add URL to some search engine, robot or spyder will visit it to get informations about keywords and theme of your site.


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offer pet-friendly accommodations along with water bowls and treats.
flat-screen TV with satellite programming and a work desk.


What is the promise that technology holds for each of our organizations and for our work? The answer is always multi-layered. Nonprofit organizations, networks and associations have made many ambitious attempts to incorporate technology tools and strategies into the way they do their work. Very often these same groups, whether successful or not at technology integration, find that information and communication technology profoundly affects the organizations' ideas about how their work can and should be done. There is, as a result, a kind of rapid co-evolution of our ideas about what an organization should look like and about what role technology can play in our work.
Some of the advances we have observed in nonprofits include: diminished barriers to carrying out programs and developing strategy; stronger connections to constituents and to accountability mechanisms; and achievement of critical mass v ia networks of networks. However, the ability of nonprofits to achieve these objectives depends greatly on their capacity to adapt themselves for the effective use of technology. Such settings are those in which everyone is clear about purpose and vision and where there are commonly understood principles and practices in place and in continuous development; where transparency and inclusive decision making are more the norm than "command and control" management; where leaders invest in the continuous development of each staff person; where curiosity and a drive to excel abound; and where accountability is prized. These learning organizations tend to push at their own current horizons to attain progressively more effective uses of information and communications technology.
This article scratches the surface of the complex set of organizational change and human interactions triggered by the use of technology. We plan to explore how learning organizations really can effectively integrate technology, from a human systems perspective, in a later article. For now we would like to share some stories about what technology can enhance if the setting is right.
In some situations it makes good sense to replace some level of face-to-face interaction with virtual contact. Take the case of an organization that regularly convenes citizens in a rural county. Due to annually expected inclement weather the organization sees a major dip in attendance at the winter gatherings. As a result, they cancelled the winter gatherings until one citizen suggested that they start up an e-mail discussion list that citizens could use to stay in touch through the winter months. Though not used by all the citizens who show up for face-to-face convening, the e-mail list provides, for those who wish it, the opportunity to stay more closely connected with others until the snow melts.
Although there is a clear potential benefit to be gained in virtual communications, as the examples above demonstrate, we observe that technology evangelists and resisters often miss the more nuanced issues that arise as organizations consider how to supplement face-to-face with online interactions. Without attention to these issues, use of technology could even damage the depth of relationships built face-to-face. It is imperative that organizations discuss this with the stakeholders who will be affected by the use of technology.
Technology can help improve the relationship between nonprofit organizations and those they serve, organize or represent, but only if it is a priority for us. If they miss this opportunity to deepen relationships through the appropriate use of technology, nonprofits may find themselves increasingly ineffective and possibly irrelevant.
Take the case of membership-based organizations that now find themselves grappling with the public's changing expectations about "belonging" to institutionally-based organizations. "Any group of Alzheimer's caregivers, breast cancer patients, parents of learning disabled children, scholars, horse breeders—any affinity group that has a need or desire to communicate -— can start a Listserv (e-mail discussion list)," points out Howard Rheingold.1 Rheingold forecast both the PC and Internet explosions, and today he talks about the emerging combination of mobile communication and the Internet that enables people to cooperate in ways not previously possible.
The implications are immense as many organizations previously in the role of director of activity or spokesperson for community interests may find that they must become facilitators of community action as opposed to controllers of it. If they do not, some predict that people may increasingly ignore what nonprofits offer them as engaged citizens. Three examples highlight the trend that portends a new role for nonprofits: the anti-WTO (World Trade Organization) demonstration in 1999, where activists used cell phones and Web sites to fight the "battle of Seattle;" the 2000 Filipino presidential elections, where a million citizens toppled President Estrada through public demonstrations organized by cell phone-triggered text messages; and the use by U.K. automobile drivers of information and communication technology to immediately self-organize actions protesting rising oil prices. These events, all examples of what Rheingold calls "smart mobs," provide nonprofits with new opportunities to support citizen action as long as there is a willingness to adapt. If there is not, then citizens will not see organizations as necessary for such activity.
Research Group (VPIRG) demonstrates that organizations willing to be flexible can adapt quickly to turn potential threats into new opportunities. Sensing that there was great potential if they went online with traditionally offline programs, they started the first online gubernatorial debates in the state and were able to instantly take questions for the candidates via the Web. "All of this," comments Mark Flogel from VPIRG, "has kept us focused on getting more information, more quickly, to more people, so they can act and stay informed." Though VPIRG had a long history of strong relationships with their constituents, the new online debates punctuated for them the importance of making most of their future decisions based on how quickly and widely they could distribute information to engage people.
Today we see organizations more and more interested in technology-enhanced "feedback loops" in the form of online surveys and tools that allow Web users to instantly comment on others' articles. The Alliance of New York State Arts Organizations, a statewide arts service organization, considered adding a group insurance program for medical, dental, disability, life and long-term care services. Alliance staff members had anecdotally heard from members and other nonprofit arts organizations that people wanted the benefits, but staff needed to see how widespread the interest was. Using an online survey tool, the Alliance was able to quickly survey its arts organizations around the state. It learned there was enough interest to begin working with an insurance vendor to put a program together. This example is not an isolated use; the Alliance regularly communicates with its constituents via e-mail and requests feedback through online surveys to make programmatic decisions.
We all know that life is full of paradoxes, silver linings and two-sided coins. So it is with technology tools and the strategies we use to take advantage of the tools.
The authors wish to caution readers that an abundance of literature and our own experiences suggest there are types of organizational settings that are much better suited to the fully effective use of technology than others. As noted at the outset of this article, technology cannot work effectively without well-functioning human systems. Organizations that excel in learning and adapting tend to push at their own current horizons to progressively more effective uses of information and communications technology.
In the context of increased technology-based communication, human (face-to-face) contact can sometimes be seen as less important than it once was. It is, in fact, increasingly important but can be done more strategically. Collective development of programs and strategy requires a certain level of understanding of one another's thinking processes and embedded assumptions. We all come to our work with a wealth of "knowledge" about things, much of which others would question if they knew we thought such things. But this "knowledge" informs what we pay attention to and the way that we see things. These are called mental models and the exposing of these to one another is often best done face-to-face when we are engaged in developing the vision for a collective project or product.This deeper level of communication, where people can honestly challenge one another's assumptions, is an important step to building the conditions for more successful online communication. And for many organizations, it is a new discipline.
Marc Osten is founder and a senior partner in Summit Collaborative, and Dot Org Media. Ruth McCambridge is the editor-in-chief of the Nonprofit Quarterly.


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Kindergarten in Nerkin Karmir Aghbyur
Nerkin Karmir Aghbyur (NKA) is a village with 1,380 residents in the Bert area of Armenia's Tavush Region. This community lives on the border with Azerbaijan under the risk of sniper fire and renewed armed conflict. The kindergarten currently can serve only 25 village children due to its physical condition and the fact that part of the building and playground is exposed to Azerbaijan. The kindergarten is housed in a building that also contains the newly renovated village medical center (a completed Paros 100 for 100 Project) and the village administrative office.
The kindergarten consists of two floors and totals approximately 4,600 square feet. The first floor is the kitchen, bathroom and playroom. The second floor is currently not in use because of its condition and the fact that four windows face Azerbaijan and are within sniper range. As recent as May of 2013 this building was hit with sniper fire. Four windows on the second floor would be blocked shut. The second floor would ultimately house the kindergarten's storage room, principle's office, a room to allow the children to nap during the day, and a classroom. The kindergarten needs a new roof over its portion of the building, new windows and doors and a heating system. Its current bathroom and staircase needs to be redone. The facility would also be completely painted and have new flooring and carpet installed. The floor support structure beneath the first floor also needs to be repaired to support the existing flooring, as there are some minor structural issues that must be corrected.
Any partial funds received for this project will be first used to replace the damaged roof. Then funds will be allocated to replace the windows and secure the building and playground from exposure to Azeri sniper fire and ultimately complete the needed interior renovations. The Paros Foundation team will work with the village administration to ensure that they support the project in as many ways as possible including donated materials, free labor and/or support services.
It is anticipated that the repairs to the kindergarten will take approximately three months depending on weather conditions.
The Nerkin Karmir Aghbyur kindergarten and playground is exposed to Azerbaijan.
The kindergarten building has several leaks in the wall, crooked floors, unsafe and unstable stairs and is in need of a complete renovation.
The room in which the children take naps has windows directly facing Azerbaijan and is vulnerable to sniper fire.
Children at the Nerkin Karmir Aghbyur kindergarten having lunch.
Children received new beds and linens for nap time!
Kindergarten education is important for all children. The children in the village of Nerkin Karmir Aghpyur are limited in their opportunities because many more children would like to attend kindergarten then the current facility allows. In addition, villagers living in this isolated border village are under the constant threat of enemy fire and renewed armed conflict. A normal functioning kindergarten that is safe and can facilitate the resident's needs is important for this community.
The renovation of the kindergarten will immediately better facilitate the educational needs of the residents in this village. Materials will be purchased locally when possible, thus providing a boost to the local economy. Several local workers will be hired during the renovation process and thus provide these residents short-term employment.
In order for a community to thrive, its residents must have access to an adequate, clean and safe kindergarten. This renovation will impact the lives of all of the residents of the village of Nerkin Karmir Aghpyur and their children.
All sponsors will be recognized with a plaque installed in the newly renovated kindergarten. In addition, donors will be recognized on all relevant press regarding this project and on The Paros Foundation Website. Visits to the village and kindergarten will be arranged for sponsors visiting Armenia.
Mr. & Dr. Jean-Marie & Lori Atamian
New York, NY December 25, 2015
New York, NY April 24, 2014
Video Update
A local construction crew was hired and has begun work on the kindergarten in NKA. The supplies have all arrived safely.
Per the request of the mayor of the village, the decision was made to reconfigure the rooms and windows in order to optimize safety and protect the children from Azeri sniper fire. The local construction crew blocked off several windows on the second floor with tufa stone, and created smaller windows elsewhere, to let in light.
The local crew is working on the roof, which was damaged from leaks as well as Azeri snipers. The roof will be replaced with corrugated metal roofing. The crew also began work on the interior of the kindergarten including the floors, walls, basement and electrical work.
Construction has begun on a security wall that will block the playground and the entrance of the kindergarten. This will become the first ever security wall built in Armenia.
Work in the interior of the kindergarten is moving along nicely. New doors, and the remaining windows have been installed and work on the new staircase is also progressing. The restroom will also be fully renovated.
The art teacher at the local school was hired to design and paint welcoming and child-friendly images for the kindergarten.
After months of hard work, the renovations at the kindergarten have been completed and the village awaits the opening celebrations.
Today Azeri snipers shot toward she kindergarten and damaged the roof and walls of the building, as well as a villager's car. Thankfully none of the village residents were hurt. A small crew will work throughout the weekend in order to quickly make the necessary repairs.
The ribbon cutting and school opening celebrations was very successful. Families attended with their children and were looking forward to sending their children to the new, warm and most importantly safe kindergarten.


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import java.lang.annotation.Retention;
import java.lang.annotation.RetentionPolicy;

@Retention(RetentionPolicy.RUNTIME)
public @interface Dependencies {
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On Tuesday 19th December 2017 at 1.30pm Salford Red Devils Foundation will unveil the Willows Mosaic on Lance Todd Close.
Those attending are then invited back to Chandos Sports and Social Club. Ahead of the event Supporters' Trust member Paul Whiteside caught up with John Blackburn of Salford Red Devils Foundation.
Today I met with John Blackburn from Salford Red Devils Foundation to chat about the fantastic mosaic at the Willows which was funded by a heritage lottery grant. John was really excited about this project which is now ready to be unveiled this Tuesday 19th of December at 1:30pm. The mosaic was designed by local man and ceramicist Rob Lally. After so many years playing at the Willows, all the history that was made there and great players that graced the turf of the old place this tribute seems very fitting.
Two local schools St Luke's C of E on Weaste Lane and Lark Hill Primary on Liverpool Street were also heavily involved. The Foundation visited both schools for five weeks working on designs which the children thoroughly enjoyed.
The position of this exquisite piece of work is round about 20 metres from the old North Stand end of the famous old Willows ground.
Everyone is welcome to attend the unveiling when the ribbon is cut. There promises to be some famous Salford RLFC names there from the past and the present. Following the unveiling ceremony everyone is welcome back to the Chandos Sports and Social Club for refreshments where the fantastic and hugely nostalgic Willows memories film will be shown. The film has recently be shown at the Lowry Theatre and captures the true spirit, heritage and glory of our special Rugby League Club Salford.


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"We just wanted to make a very powerful but dark mid-tempo heavy hitter" – Introducing: Awake Again
What do you get when the craziness of System of a Down meets the electronic mayhem of Enter Shikari wrapped in the production of Bring Me The Horizon? You get Awake Again which is a four-piece alternative metal band hailing from Turku, Finland formed in 2013. Their music a distinctive mixture of metal, post-hardcore, and pop. Known for their huge and catchy songs accompanied with a live performance like a nuclear bomb Awake Again has been making a steady rise in the Finnish metal scene.
Having played over 100 shows the band has conquered smaller and bigger stages with their wildfire like energy. Most notably they won Wacken Metal Battle Finland in 2018 and got to show their alternative metal madness at the global finals in Wacken Open Air. The fall of 2020 started a new chapter in Awake Again's career as the band released highly anticipated new music. Bigger, heavier, and more melodic than ever before Awake Again is ready to conquer the hearts of music lovers around the world. We had a conversation with the band's bassist, Ville Loukola.
Beginnings:
Matti (vocals), Kasper (guitar) and Markus (drums) founded the band in 2013. They were friends and playing in different bands and lineups here in Turku. After all the previous bands were not going anywhere they wanted to form a serious band that aims high and doesn't stop. First, they started as a trio since Matti was also playing bass along with lead vocals. In 2015 the band was chosen to Turku Rock Academy band coaching program. At the same time, they started to look for a separate bass player to get the vocals, bass, and live performance to the next level. That's where I jumped in. My previous band broke up the day before the guys in Awake Again started to look for a bassist and since I knew the Awake Again guys and really liked their music it was kind of meant to be.
Behind the name:
Being "awake again" is getting back to the mental stage of a small child where you are free of presumptions, stereotypes, or general frames of thinking and you just experience the world as it is. And the world is exciting, inspiring, and vibrant in that way.
The initial main influence was Enter Shikari. Nowadays we describe ourselves as "when the electronic mayhem of Enter Shikari meets System of a Down wrapped in the production of Bring Me The Horizon" so I guess those three bands are our main influences. All of us enjoy all kinds of music so we draw inspiration from many places.
Inspiration behind "Look Around":
I guess we just wanted to make a very powerful but dark mid-tempo heavy hitter. It's a little different kind of song than the rest of our catalog but that's cool since we don't want to repeat ourselves. This single is actually an older song. It has been a part of our live set for a long time in its previous forms and with the help of producer Lauri Hämäläinen it got its final form. As the album goes our plan is to release it in the fall of 2021 and a few singles before that.
For our first music video "Turning Point" we spent countless hours planning and making tons of movie and other pop culture references. I believe there were 43 of them. Not sure if anyone noticed any of them, but if there is a real movie geek out there take it as a challenge to find all of them. Another could be that when we played in Ruisrock Matti ran into the ocean during one song. We were playing on a stage that was near the water and when this instrumental bridge part kicked in Matti ran like hell to the water and back. It was in a matter of milliseconds that he managed to get back in time to sing when the vocals were supposed to come back.
We have had some shows canceled and haven't tried to book any new ones. So basically the gigging has been off. For us, it hasn't been that bad because we really just wanted to release and work on new music. When we are doing shows and rehearsing and trying to keep up with the rest of the band stuff we can't seem to find enough time to work on the music itself. So this involuntary COVID-19 break has in some way worked in our favor. I guess it's some kind of silver lining in this terrible crisis. At least for us.
Online concert:
We have done a couple of live stream shows and in January we are doing another one. Those have been quite cool and interesting experiences but it's nothing compared to a real crowd and the real energy between the band and the audience.
Please check out our new single Look Around from any of the major streaming platforms! If you dig it please don't hesitate to give us a follow on Spotify, Facebook, Instagram, or Youtube. We are releasing new music in the near future and all sorts of other stuff. Once this COVID-19 bullshit is behind us we hope to see all of you in the audience. Everybody be safe and take care!
"Three words dreams are made of' – introducing: Illusions of Grandeur
"It's important to document the sound of your time" – Exclusive interview with Snow Owl


At Elder, we provide high-quality private live-in care for the elderly and those in need throughout Beverley.
At Elder, we provide high-quality and affordable live-in care for the elderly, in and around Beverley, helping members of the older generation to live a happy and comfortable life in the comfort of their own homes.
People who are now in their later years have become accustomed to independent living, and many of them dread the thought of entering residential care. They fear the loss of independence and worry about losing contact with familiar faces and places in their local neighbourhood.
What does a live-in carer in Beverley do?
Beverley is a market town and civil parish, voted one of the best places to live in the UK, renowned for its exquisite 13th Century Minster. The town is home to a market, excellent flat racing and a medieval skyline, meaning that there is more than enough for your loved one to do and see to keep them occupied. Meanwhile, you can relax knowing that they are living life to the full.
Our experience in training and vetting live-in carers ensures that our care recipients always receive the best possible live-in care in and around Beverley.
A local community charity charity offering a voluntary service aimed at helping older, disabled or isolated people to get out and about even if they find it hard to use other modes of transport.
The Carers Supports Service offers advice on everything from carers' rights, legal and financial issues and health-related concerns to carer assessments in the East Riding area and regular meetings of support groups.
Local council website providing a one-stop-shop full of information and plenty of help and advice for both older people and carers living in the local area.
Local NHS GP service offering a range of services for carers and older people.
Local leisure centre, offering many activities aimed at older residents to support them in staying as fit and healthy as possible, as well as a swimming pool.