text:
Posted by Elizabeth M. Rogers on 11/16/10 • Categorized as Drugs,Volume 1
Plavix is prescribed for more than 25 million people globally and generates in excess of $9 billion dollars in annual sales. Yet, neither the U.S. Food and Drug Administration (FDA), nor the American Heart Association can provide definitive guidance to physicians for determining which patients that need antiplatelet therapy should take Plavix (or clopidogrel, the generic version of Plavix).
These gene variants can place patients who are taking Plavix at increased risk for having life threatening, drug-related, adverse events.
The problem lies with the gene variants in the CYP2C19 drug metabolizing enzyme, which occur in 1/3 of the population (Cucasians-30%; African Americans-40%; and East Asians 55%). (Desta et al. 2002). These gene variants can place patients who are taking Plavix at increased risk for having life threatening, drug-related, adverse events. However, an adverse event in these patients cannot be predicted conclusively. The reason for this is because gene variants will interact with environmental factors and other variables (including gender and other gene variants) to cause their specific effect.
A U.S. large population-based study would have the statistical power and the protocol standardization required for scientists and physicians to obtain the evidence-based data they need to address this problem.
The problem: Patients who are prescribed Plavix and have gene variants in the CYP2C19 drug metabolizing enzyme, have loss of drug metabolizing enzyme function. This loss of function has been associated with an increased risk of death, myocardial infarction, or stroke, especially among patients undergoing percutaneous coronary intervention (PCI)" (Simon et al. 2009). In one study, individuals with at least one CYP2C19 reduced-function allele (approximately 30% of the study population), had a relative reduction of 32.4% in plasma exposure to the active metabolite of Plavix, as compared with individuals without the gene variant (Mega et al. 2009). Insufficient plasma exposure means that there are fewer Plavix drug metabolites available to bind to the adenosine diphosphate receptor (ADP) in order to prevent platelet activation, which is the job Plavix is designed to accomplish.
In another study, patients with two copies of the CYP2C19 gene variant had worse clinical outcomes when treated with clopidogrel after acute myocardial infarction when compared to patients with only one copy of the gene variant (Freedman and Hylek 2009). (We receive two copies of each gene, one from each parent. Two copies of a gene variant can increase its affect.)
Because there is no evidence-based clinical strategy for prescribing Plavix, Dr. Dan Roden, MD and Dr. Alan Shuldiner, MD published an editorial in the July 27th, 2010 NEJM, in which they reviewed the following options available for physicians who must prescribe antiplatelet inhibitors:
Do nothing; follow guidelines:
The authors suggest this as a tenable choice in the absence of availability of any other solid data or testing (Roden and Shuldiner 2010).
Use platelet function testing as an alternative, or in combination with, CYP2C19 genetic testing:
The scientists noted that platelet function testing lacks standardization. Specifically, there are inconsistent results between different platelet assays to identify clopidogrel non-responders. Many patients who are identified as non-responders with one test, are identified as good responders with other tests (Cuisset et al. 2010).
Nonetheless, the authors suggest that there may be benefits to combining platelet function monitoring and genetic CYP2C19 genetic testing to manage P2Y12 inhibitor therapy. They state that CYP2C19 genotyping testing would allow physicians to identify patients at higher risk for clopidogrel failure. Furthermore, intermittent platelet function testing would allow the clinician to address the variance in drug action while, at the same time, factoring in the CYP2C19*2 results (Roden and Shuldiner 2010).
Use prescription genotyping to guide therapy:
According to the authors, this option does not have evidence-based support. The authors note that because many cardiovascular events occur within the first few hours to days after percutaneous coronary intervention, a rapid turnaround time is essential. According to the authors, "The questions here are how and whether to adjust clopidogrel dose, or to choose an alternative drug; and in whom: just poor metabolizers (*2/*2 homozygotes) or also in intermediate metabolizers (*1/*2 heterozygotes)? In addition, third-party payers may or may not reimburse for genetic testing without the evidence base to support its efficacy" (Ibid).
"Ignore clopidogrel and prescribe "alternate P2Y12 receptor inhibitors" (i.e., prasugrel for now) to all":
The authors point out that for now, the alternative platelet inhibitor "Prasugrel," from Daiichi Sankyo Co Ltd and Eli Lilly and Co., does not appear to be adversely affected by CYP2C19 polymorphic genotype. They also cite data from the Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 28 (TRITON-TIME 38) study, showing that "Prasugrel resulted in fewer cardiovascular adverse events in patients, but more bleeding."
Hence, the authors note that giving Prasugrel to all patients would eliminate the need for CYP2C19 gene variant genotyping, but it would also increase "exposure to adverse bleeding complications" (Ibid).
Prescribe clopidogrel in patients without at-risk genotypes and other drugs, such as prasugrel, in subjects with CYP2C19 variant genotypes:
The authors suggest that, to increase the "benefit to risk ratio," and to also manage health care costs, a more individualized approach might be to prescribe clopidogrel in patients who don't have at-risk genotypes and prescribe other drugs such as "prasugrel" in subjects with CYP2C19 variant genotypes. "This option might also be cost effective, with clopidogrel coming off patent in 2011, and soon to be much less expensive than newer agents. However, as the American College of Cardiology Foundation/American Heart Association Clopidogrel Clinical Alert correctly points out, the evidence-base for this option currently does not exist." (Ibid)
Finally the authors state that, "clearly none of these options are well supported by data and that major issues are unsettled: e.g., which platelet function test is best, how to get timely genetic data on which to act, how to act, and the economics of genetic testing versus complications avoided" (Ibid).
These options must echo the frustration that many physicians share.
The fault, for this lack of guidance for prescribing Plavix does not lie with regulatory agencies, nor does it lie with physicians. Regulatory agencies, as well as physicians, have been informed by the excellent scientific studies that have been conducted since 2007, to understand how the CYP2C19 drug metabolizing enzyme polymorphisms affect the potential for adverse events in diverse patient population subsets that are prescribed Plavix.
However, these clinical studies could not have taken into account all of the factors that scientists suggest could contribute to the gene variant's causal role in adverse drug related events. For example:
Numerous environmental factors, specific to an individual's geographical region, may combine with a gene variant to influence adverse drug events.
Other gene variants may interact with the CYP2C19 gene variant and affect the outcome of Plavix or other antiplatelet inhibitors such as Prasugrel.
A patient's ancestral admixture, which reflects the differing proportion of individual genes that a person inherits from his ethnic ancestry, may affect the degree of clinically relevant adverse drug events.
Newly discovered small molecules that can participate in affecting protein expression patterns along drug metabolizing relevant, cellular signaling pathways, could influence Plavix outcome, such as micro RNAs (miRNAs).
New, rare gene variants may also influence clinically relevant outcomes for patients who are prescribed Plavix, and more of these are expected to be discovered as novel, Third Generation DNA Sequencing Platforms enter the marketplace.
In short, a fundamentally new genetic science is being incorporated into the health care decision-making paradigm and it is changing our conceptual framework about medical practice.
The U.S. Government made a $3 billion dollar investment to decode the human genome, in order to bring this about. In their planning, scientists, physicians, and legislators knew that this genetic data would have the potential to introduce changes within the very fabric of our health care infrastructure. However, it was difficult to anticipate what the timing and the exact nature of those changes would be. Now scientists have better information to work with. Specifically, they know that they have diverse sets of genomic data that must be cross referenced and analyzed in what Gregory Feero, Alan Guttmacher, and Francis Collins, in a recent NEJM article, described as, "a longitudinal living laboratory," operating across the nation (Feero, Guttmacher and Collins 2010).
Such a living laboratory would serve to help scientists and physicians elucidate the relationship between adverse drug responses, and an individual's genetic make-up.
As Feero, Guttmacher and Collins noted in their article, the amount of genetic data available is enormous and it is still growing. "The wealth of scientific discovery generated over the past 10 years is unparalleled in the history of biomedicine. Moreover, the rate of discovery is accelerating" (Feero et al. 2010).
Hence, the U.S. Health Care Infrastructure is at a unique juncture. The situation requires that the U.S. Health Care System design a new personalized medicine component that will enable a dynamic, multidiscipline team to conduct a large population-based study spanning multiple regions across the nation. Such a study might include more than a million people in its design.
This type of study will provide the statistical power, and protocol standardization necessary, to arrive at clinical strategies for evidence-based medical decisions that will incorporate patient genotypes.
Today, scientists and physicians at different locations across the nation are working on different aspects of personalized medicine and health care system components that could possibly become part of a larger system design. One goal might be to bring these scientists and physicians together with their regional counterparts, to create a collaborative venture and work as a team to expand the design, development and implementation of these system components across the nation.
For example, Marylyn Ritchie and her colleagues at Vanderbilt University School of Medicine, in Nashville, TN, recently published an article describing a study they completed. The study demonstrated that the Vanderbilt DNA repository data bank, "BioVu," could be successfully linked to their electronic medical records database, in order to generate large numbers of "subjects." These subjects could then be used as both "cases" and "controls," across multiple diseases, in studies to be conducted by scientists and physicians (Ritchie et al. 2010).
Today, scientists and physicians at different locations across the nation are working on different aspects of personalized medicine and health care system components that could possibly become part of a larger system design.
The important work done by these scientists could create a model for linking electronic medical records to DNA repositories, in order to augment or supplement traditional research designs that enroll cases and controls prospectively, while at the same time systematically collecting relevant phenotype (physical expression) data. Such a system would accommodate a statistically powerful, large population-based study that could be implemented in regions across the nation.
In a second example, Cathy Schaefer, Ph.D, and Neil Risch, Ph.D., are co-directing a research program on "Genes, Environment, and Health," that will support the genome-wide analyses of DNA samples from 100,000 Kaiser Permanente members.
To accomplish this, Kaiser Permanente will use Affymetrix's "Axion Genomics Solution" on the Gene Titan Microarray Platform to genotype these patients. Permanente will use the genotype data to discover which genes, in combination with environmental factors (such as the air we breathe, the water we drink, the food we eat, and our lifestyles and habits), are linked to specific diseases and their onset and progression, as well as to adverse drug events.
This new and detailed genetic information, which for the first time is being generated on such a large and diverse population, will be linked to decades of historical, clinical and other health-related information on these study participants, that will be obtained from health surveys contained in the Kaiser Permanente electronic health records. This data can then be used by physicians to design strategies to help their patients delay and/or prevent disease onset. Furthermore, it can be used to determine if these strategies are working. This patient genotype data will also be used by physicians to better understand what drugs might produce an adverse reaction in their patients and design strategies to prevent them.
The Kaiser Permanente program may be well suited as a model for a second component of a U.S. large population-based study that could operate regionally across the nation. This would include the analysis of environmental factors in combination with gene variants in order to understand how potential adverse drug events occur.
Risch, who also holds positions in Genetics and Epidemiology at the University of San Francisco (UCSF), in CA, has also worked with his colleagues at UCSF to study and incorporate ancestral admixture data into genotyping analysis. Hence, this newly emerging aspect of genotyping will most likely be accounted for in the program under development by Kaiser Permanente.
These are only two examples of programs that can be used as models for a U.S. Regional Health Care Infrastructure that could include a personalized medicine division, with the requisite system components in place to launch a Large Population-Based Study.
I am sure there are also other models of workable system components under development within organizations at other locations across the U.S.
Moving forward to implement this concept, one might start by identifying these organizations to find out if they would consider bringing their works-in-progress into a collaborative format.
Importantly, such a collaboration among organizations like Vanderbilt, Kaiser Permanente, and the University of California at San Francisco, with select regional health care centers around the country, would enable the U.S. to be one step further along in its vision for conducting a Large Population-Based Study, that informs the growth of evidence-based decision making in personalized medicine across the United States.
Accomplishing this goal was explored in a report that was delivered to the U.S Health and Human Services (HHS) Secretary in 2007, by the Secretary's Advisory Committee on Genetics, Health, and Society (SACGHS).
A key finding in the report supported the creation of a Large Population Based Study (LPS). According to the Report:
On the basis of the knowledge gathered… the committee believes that a new LPS in the United States could lead to improved diagnostics, treatments and preventative measures for common diseases such as cardiovascular disease, diabetes, and cancer.
Hence, a Large Population Based study may be what is next as an option that supports evidence-based medicine for physicians.
Cuisset, T., C. Frere, R. Poyet, J. Quilici, B. Gaborit, L. Bali, O. Brissy, M. Lambert, P.-E. Morange, M.-C. Alessi & J.-L. Bonnet (2010) Clopidogrel response: Head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting. Archives of Cardiovascular Disease, 103, 39-45.
Desta, Z., X. Zhao, J.-G. Shin & D. A. Flockhart (2002) Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clincal Pharmacokinetics, 41, 913-958.
Feero, W. G., A. E. Guttmacher & F. S. Collins (2010) Genomic Medicine – An Updated Primer. NEJM, 362, 2001-2011.
Freedman, J. E. M. & E. M. M. Hylek (2009) Clopidogrel, Genetics, and Drug Responsiveness. New England Journal of Medicine, 360, 411-413.
Mega, J., S. Close, S. Wiviott, L. Shen, R. Hockett, J. Brandt, J. Walker, E. Antman, W. Macias, E. Braunwald & M. Sabatine (2009) Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation, 119, 2553-60.
Ritchie, M., D. , J. C. Denny, D. C. Crawford, A. H. Ramiez, J. B. Weiner, J. M. Pulley, M. A. Basford, K. Brown-Gentry, J. R. Balser, D. R. Masys, J. L. Haines & D. M. Roden (2010) Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record. The American Journal of Human Genetics, 86, 560-572.
Roden, D. M. & A. R. Shuldiner (2010) Responding to the Clopidogrel Warning by the US Food and Drug Administration. Real Life Is Complicated. Circulation, 122.
Simon, T., C. Verstuyft, M. Mary-Krause, L. Quteineh, E. Drouet, N. Meneveau, P. G. Steg, J. Ferrieres, N. Danchin & L. Becquemont (2009) Genetic Determinants of Response to Clopidogrel and Cardiovascular Events. New England Journal of Medicine, 360, 363-375.


text:
#region License
// Copyright (c) Amos Voron. All rights reserved.
// Licensed under the Apache 2.0 License. See LICENSE in the project root for license information.
#endregion

using QueryTalk.Wall;

namespace QueryTalk
{
    public static partial class Extensions
    {
        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="sentence">A predicate sentence.</param>
        public static T BelongingTo<T>(this T node, ISemantic sentence)
            where T : ISemantic
        {
            return AddPredicate(node, sentence, true);
        }

        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="expression">A predicate expression.</param>
        public static T BelongingTo<T>(this T node, Expression expression)
            where T : ISemantic
        {
            return AddPredicate(node, expression, true);
        }

        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="argument1">The first argument in the equality expression.</param>
        /// <param name="argument2">The second argument in the equality expression.</param>
        public static T BelongingTo<T>(this T node, ScalarArgument argument1, ValueScalarArgument argument2)
            where T : ISemantic
        {
            return AddPredicate(node, argument1, argument2, true);
        }

        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="quantifier">A quantifier of a predicate.</param>
        /// <param name="sentence">A predicate sentence.</param>
        public static T BelongingTo<T>(this T node, Quantifier quantifier, ISemantic sentence)
            where T : ISemantic
        {
            return AddPredicate(node, sentence, true, quantifier);
        }

        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="quantifier">A quantifier of a predicate.</param>
        /// <param name="expression">A predicate expression.</param>
        public static T BelongingTo<T>(this T node, Quantifier quantifier, Expression expression)
            where T : ISemantic
        {
            return AddPredicate(node, expression, true, quantifier);
        }

        /// <summary>
        /// <para>Provides a predicate of a subject. A subject with a predicate returns equal or less rows than a subject without a predicate.</para>
        /// <para>All predicate methods are logically identical.</para>
        /// </summary>
        /// <typeparam name="T">The type of the subject node.</typeparam>
        /// <param name="node">A subject node.</param>
        /// <param name="quantifier">A quantifier of a predicate.</param>
        /// <param name="argument1">The first argument in the equality expression.</param>
        /// <param name="argument2">The second argument in the equality expression.</param>
        public static T BelongingTo<T>(this T node, Quantifier quantifier, ScalarArgument argument1, ValueScalarArgument argument2)
            where T : ISemantic
        {
            return AddPredicate(node, argument1, argument2, true, quantifier);
        }

    }
}

redpajama_set_name: RedPajamaGithub


text:
Moonrise and moonset » Indonesia » Jakarta
Moonrise and moonset Jakarta, Indonesia
Year 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030
1 February 2023, Wednesday - 02:01 14:53
2 February 2023, Thursday - 02:51 15:45
3 February 2023, Friday - 03:43 16:35
4 February 2023, Saturday - 04:33 17:24
5 February 2023, Sunday - 05:24 18:10
6 February 2023, Monday - 06:12 18:53
7 February 2023, Tuesday - 06:58 19:34
10 February 2023, Friday - 09:10 21:29
11 February 2023, Saturday - 09:54 22:09
12 February 2023, Sunday - 10:40 22:52
13 February 2023, Monday - 11:31 23:39
14 February 2023, Tuesday - 12:25 -
15 February 2023, Wednesday 00:31 13:25 -
16 February 2023, Thursday 01:31 14:27 -
17 February 2023, Friday 02:34 15:33 -
18 February 2023, Saturday 03:40 16:35 -
19 February 2023, Sunday 04:45 17:35 -
20 February 2023, Monday 05:47 18:28 -
21 February 2023, Tuesday 06:45 19:18 -
28 February 2023, Tuesday - - 12:47

redpajama_set_name: RedPajamaCommonCrawl


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text:
Das ehemalige Hotel Krone mit der Anschrift Kleiner Kornhausplatz 1 ist ein denkmalgeschütztes Bauwerk der kreisfreien Stadt Kempten (Allgäu). Es wurde 1844 erbaut; das Portal ist mit F. H. S. 1844 bezeichnet. Es befindet sich direkt hinter dem Kornhaus.

Das ehemalige Hotel, das einige Jahre als Kinderkrankenhaus genutzt wurde und mittlerweile als Sitz für lokale Vereine und Verbände dient, ist ein Walmdachbau. Die Fassade des ersten Geschosses ist mit kannelierten Lisenen gestaltet. Die beiden Obergeschosse sind mit einem Zahnschnittfries vom unteren Stockwerk getrennt und haben durchgehende Lisenen.

Einzelnachweise

Weblinks

Ehemaliges Hotel in Bayern
Baudenkmal in Kempten (Allgäu)
Umgenutztes Bauwerk in Kempten (Allgäu)
Ehemaliges Unternehmen (Kempten (Allgäu))
Erbaut in den 1840er Jahren

redpajama_set_name: RedPajamaWikipedia


text:
package classpackage;

import javafx.beans.binding.NumberBinding;
import javafx.beans.property.*;

/**
 * An object for saving the data of one purchase order line.
 * Contains the metadata itself as as well as an object representing the ingredient that's being obught.
 * A number binding calculating the total price of the line is also provided.
 */
public class POrderLine {

	private IntegerProperty pOrderId = new SimpleIntegerProperty();
	private ObjectProperty<Ingredient> ingredient = new SimpleObjectProperty<>();
	private DoubleProperty quantity = new SimpleDoubleProperty();
	private BooleanProperty checked = new SimpleBooleanProperty();
	private NumberBinding totalBinding;
	private DoubleProperty total = new SimpleDoubleProperty();

	/**
	 * Constructor for retrieving the purchase order line from the database.
	 * @param pOrderId	The ID of the purchase order. Automatically generated when the order was inserted into the database.
	 * @param ingredient	An object containing the data of the ingredient that is being bought.
	 * @param quantity	The quantity of the ingredient being bought.
	 */
	public POrderLine(int pOrderId, Ingredient ingredient, double quantity) {
		this.pOrderId.set(pOrderId);
		this.ingredient.set(ingredient);
		this.quantity.set(quantity);
		totalBinding = this.quantity.multiply(ingredient.priceProperty());
		total.bind(this.totalBinding);
	}

	/**
	 * Constructor for creating a new purchase order line from the GUI. Missing ID, which is later inserted by the database.
	 * @param ingredient	An object containing the data of the ingredient that is being bought.
	 * @param quantity	The quantity of the ingredient being bought.
	 */
	public POrderLine(Ingredient ingredient, double quantity) {
		this.ingredient.set(ingredient);
		this.quantity.set(quantity);
		totalBinding = this.quantity.multiply(ingredient.priceProperty());
		total.bind(this.totalBinding);
	}

	public int getpOrderId() {
		return pOrderId.get();
	}

	public IntegerProperty pOrderIdProperty() {
		return pOrderId;
	}

	public void setpOrderId(int pOrderId) {
		this.pOrderId.set(pOrderId);
	}

	public Ingredient getIngredient() {
		return ingredient.get();
	}

	public ObjectProperty ingredientProperty() {
		return ingredient;
	}

	public void setIngredient(Ingredient ingredient) {
		this.ingredient.set(ingredient);
	}

	public double getQuantity() {
		return quantity.get();
	}

	public DoubleProperty quantityProperty() {
		return quantity;
	}

	public void setQuantity(double quantity) {
		this.quantity.set(quantity);
	}

	public double getTotal() {
		return total.get();
	}

	public boolean isChecked() {
		return checked.get();
	}

	public BooleanProperty checkedProperty() {
		return checked;
	}

	public void setChecked(boolean checked) {
		this.checked.set(checked);
	}

	public ReadOnlyDoubleProperty totalProperty() {
		return total;
	}
}


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Ensure your device has it's wireless (WiFi) option enabled and search for your broadband connection. One found, select the connection and you will be asked for the key or password, use the SSID or password provided (usually on a sticker on the bottom of your router). Alternatively, follow the on-screen instructions to connect.
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You can now set up Netflix directly from your BT remote control. Use your YouView remote control and select "menu", navigate to "Players & Apps" and select the Netflix option. As long as you are connected to the internet through BT and have been for more than two hours, you'll be able to access Netflix.
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Check to see if your phone line is working. Plug in a phone and attempt to make a call. If you cannot make a call, you won't have a connection for your broadband.
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Can I keep my number if I switch mobile provider to BT Mobile?
Generally yes, you may be able to keep your number when you switch to it. To do this, you'll need to get a PAC code, which is a 9-character list of numbers or letters. This allows mobile network providers to transfer one number from one network to another. Transferring your mobile number takes up to 24 hours once you've given your mobile provider their PAC code. To receive this code simply call the BT contact number listed above and they will help you through the process.
If you have a My BT account then you may be able to manage your account, view your bill and view your charges and payment plan online. To do this you need to visit the homepage and log in to 'My BT'.
If you don't yet have an account then it's possible to set one up. To do this you will need associated information relevant to your account, including your telephone number or account number. You can then visit the website or call the BT broadband contact number to set up an account and begin enjoying the benefits of online account management.
BT TV is a television subscription service which caters to well over a million customers. It offers a number of sports, movie, and entertainment channels, including in HD.
If you're looking for an alternative or new TV subscription service which provides premium on demand content as well as additional channels then you may wish to consider signing up to use BT TV. It has also recently upgraded its service and rebranded it to be named 'YouView'. If you previously had this subscription service then you may be upgraded to YouView as the new service free of charge. For any more questions or concerns about this service then please get in contact with them either online or at the BT telephone number or through email to find out more.
How can I report a fault to BT regarding my landline?
There are many ways to report problems or faults with your service to them. You can do this directly over the phone with the BT customer service number listed above or alternatively you can use their online fault tracking and reporting service which is available on the My BT homepage.
Bear in mind that you may also wish to check the network coverage and network status of your area before reporting the fault as there may be external factors, for instance extreme weather, which are affecting the service in your area.
I want to know my broadband speed – how can I find it out?
BT have an online tool to help you work out your download speed and your overall broadband speed, and you can find this on your website. However, there are many other websites that also provide this free service, such as Speed Test (speedtest.net).
If you've found that your broadband speed has just decreased significantly then you may wish to check the network connections in your area and see if there is a network issue affecting other systems too. Otherwise, you can get in touch with BT broadband customer service directly to enquire about this issue.
If you're watching BT Sport or your BT TV package online and you are having trouble viewing, there are several possible reasons that may be causing this. One of these may be the browser you're using and if you have Flash enabled. This is usually when the box appears 'greyed out' on your screen. To remedy this situation you must install or update Flash.
One thing you may also wish to do is note down the precise error code that you are receiving, this should be displayed on your screen. Following this, you should be able to research online or contact BT broadband customer services representative to find out what the problem is with your viewing.
Does BT Have Parental Control Options?
Yes, they offer a service called BT Parental Controls which allows parents to restrict access to certain content and sites on the internet. It's very easy to use this filter to block certain sites, and you can even set up 'homework time' when the Internet is restricted.
You may wish to use the Parental Control Options if you have young children and are worried about content they are accessing on the internet. There are many ways to set this up, and you may be able to do so over the phone by calling the BT broadband phone number at the top of this page or on their website.


NFL Forum :: - Jaws comments on Cards vs Brady.
Jaws comments on Cards vs Brady.
Posted: Thu Sep 20, 2012 4:12 pm Post subject: Jaws comments on Cards vs Brady.
I don't have insider but am interested in what Jaws had to say. Anyone?
Posted: Thu Sep 20, 2012 4:18 pm Post subject: Re: Jaws comments on Cards vs Brady.
Not me, I do know however that when Jay Feely talked to Tom after the game (The two of them used to room together at Michigan) Tom said "I had no idea what you guys were doing".
Posted: Thu Sep 20, 2012 7:45 pm Post subject: Re: Jaws comments on Cards vs Brady.
Posted: Fri Sep 21, 2012 12:50 am Post subject: Re: Jaws comments on Cards vs Brady.
From his house in Malibu while his backup abused us.


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INK: A PIECE FOR MUSEUMS
A new show for art museums and theater spaces alike, Ink is an art lecture, live personal essay, and electronic music concert all in one. With stunning visuals by media designer Shawn Duan, James & Jerome perform a lush live score as they lovingly analyze works from around the world, exploding the traditional art lecture into a unique theatrical experience—one that's at once playful, intellectual, and spiritual. Together they guide us through a meditation on calligraphy and illuminated manuscripts, on music and silence, and on Jerome's intimate relationship to the spoken and written word.
On January 5-6, 2019, Ink will be presented in the first-ever collaboration between The Public Theater's Under the Radar Festival and The Metropolitan Museum of Art. Tickets and more information here.
Written, composed, and performed by James & Jerome in collaboration with Media Designer Shawn Duan. Directed by Rachel Chavkin and Annie Tippe. Associate Media Designer: Caroline Trewet. Lighting Designer: Jeanette Oi-Suk Yew. Stage Manager: Bob Brownell. Developed through BRIC Arts Media's BRIClab and The Ground Floor at Berkeley Rep.
All photos by Marcus Middleton.
Ink also has a sister piece, called Tour—a guided tour of art museum galleries, curated for individual collections, with a live score.


text:
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NORTHWEST TECHNOLOGY NEWS
Monday June 17 2019
ParkVia's Booming Success Recognised With Celebratory Accolades
Manchester-based online parking reservation leader, ParkVia, has this week celebrated two significant award achievements, culminating a successful first half of 2019 for the airport parking retailer.
Having previously announced in April that the company had been awarded its second prestigious Queen's Award for Enterprise in the category of International Trade under its former brand name (ParkCloud), this week saw Managing Director Mark Pegler receive official recognition from HRH The Prince of Wales.
In a reception held at Buckingham Palace, Mark, together with Commercial Director Dr Valentina Moise, joined the UK's other 128 International Trade winners to celebrate the innovative services being provided by British businesses to countries across the globe.
In addition to the Queen's Award reception, ParkVia has also been recognised by the International Parking and Mobility Institute (IPMI) this week at its annual conference in Anaheim, California.
IPMI's Marketing Awards recognise outstanding parking and mobility-related marketing, public relations and communications programmes that demonstrate innovation through multi-faceted campaigns.
ParkVia was presented with the esteemed industry accolade, having impressed the judges with its thought-provoking campaign surrounding the PARK(ing) Day initiative, which shone the spotlight onto the need to creatively revamp urban parking areas.
Together with European parking operator, Q-Park, ParkVia's campaign concluded in an event to showcase the best of the North West's young artistic talent as part of PARK(ing) Day's international celebrations in September 2018.
Speaking about the company's recent achievements, ParkVia's Commercial Director, Dr Valentina Moise, said:
"It has been a very rewarding week for the team, not only being championed by HRH The Prince of Wales, but also being recognised by our industry peers internationally. We're delighted that the business is growing from strength to strength and it's extremely gratifying to see the team's efforts recognised by such prominent awarding bodies."
The Lord Lieutenant for Greater Manchester will officially present ParkVia with its Queen's Award for Enterprise trophy in September at its head offices in Manchester.
To find out more about ParkVia, please visit www.parkvia.com.
"Were delighted that the business is growing from strength to strength and its extremely gratifying to see the teams efforts recognised by such prominent awarding bodies."
ParkVias Commercial Director, Dr Valentina Moise
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The Recently Persistent UFO Sightings Over Manchester, England
UFOs, Sightings
Admittedly Manchester, England isn't the first place that comes to mind when discussing UFO hotspots or waves of strange sightings. However, in recent years, many strange encounters have taken place in the skies over the city. And it would appear these incidents are actually increasing. While no doubt many of them, upon investigation, will prove to have explanations of a reasonable, if mundane nature, some will prove to be much more elusive in isolating just what these strange objects are.
A depiction of a UFO over Manchester
One particular sighting in the summer of 2011 over the Denton area of the city was captured on film. The sighting appeared to take place around late-afternoon in early-July. A cigar-shaped object is clearly visible as it rises higher into the skies above. There appears to either be lights, or a reflection of the early-evening sun along the side of the craft. The witness would state it was visible for around forty minutes before finally disappearing out of range of their sight.
The footage is a little shaky due to the fact the witness had to use full-zoom to focus on the craft. This perhaps tells how high it actually was. And the possible magnitude of the size of it. You can view the video of that sighting below.
1 Twenty-Three Sightings In A Year!
2 Multiple Crafts, Formation Flying, And Possible Abduction?
3 The 2014 "Glitch In The Cloud" Sighting!
4 Encounter On The M5
5 Strange Activity Goes Back Decades!
6 The Little-Known Lyme Park Incident
6.1 Another Eyebrow Raising Detail!
7 Other Similar Cases At The Same Time?
Twenty-Three Sightings In A Year!
In February 2016, a story appeared in the Manchester Evening News stating that, according to MUFON, they had received twenty-three reports of UFO sightings over the skies of the Greater Manchester area [1] in the year from January 2015 to January 2016.
The sightings range in detail, and in outlandishness. For example, according to one report, on 10th January 2015, the unnamed witness noticed a humming sound before seeing a strange object land in a field. Entities emerged from this object and appeared to inspect their surroundings before getting back in their vehicle and leaving with great speed. The most startling detail offered, however, was that sheep who were grazing nearby suddenly "exploded". Whether this was an intentional act on the alleged visitor's part, or just a consequence of the small flock simply being in the wrong place at the wrong time is perhaps open to debate.
Only weeks later, on 21st February, a ball of "bright white light" was witnessed. It was moving in and out of the clouds through the night sky. It would move at "high speed", eventually entering a thick bank of cloud and disappearing. Almost exactly a month later, on 20th March, at just after 9 am on the morning of the much-anticipated eclipse, a witness in nearby Stockport witnessed a "strange light" in the suddenly grey sky as they snapped a photo of the event. The light vanished in an instant but was visible in the picture.
On the 21st September, in the middle of the afternoon at 1:30 pm, two "disc shapes flying at different heights" were witnessed for several minutes. They too suddenly vanished from sight.
UFO over Manchester, 2011
Multiple Crafts, Formation Flying, And Possible Abduction?
Several sightings speak of multiple crafts, at times even flying "in formation". On 24th August, for example, no less than five crafts were witnessed in the skies over Bury, Lancashire. The witness would describe them "like they were playing tag". They would state that three of the strange crafts "shot into cloud" before vanishing from sight. The remaining two aerial vehicles would swirl around the clouds before also disappearing into them at lightning pace.
On 27th September, just before noon in Wigan, "five shiny metallic objects" were seen clearly flying through the sky in a "triangle formation". Only days later, at around 7 am on 30th September, a resident of Ashton Under Lyne witnessed a strange craft "flying side by side" with an airliner. It would continue on this route for several seconds before suddenly performing a sharp right turn and vanishing directly upwards.
Perhaps one of the strangest of these recently highlighted UFO encounters, though, was one that took place in the early hours of 9th February 2016. At around 1 am, just as the witness was dropping to sleep, a strange sensation in their room compelled them to look out of the window. An airborne object that "made very rapid movements and went in every direction" at unbelievable speeds would fill their vision. The witness would further state that they "knew instantly what it was". Later in the night, the witness claimed to wake to see an alien's face above their bed. Thinking it was a dream, they would go back to sleep. The following day, they would discover a small scar on their back that wasn't there previously.
The 2014 "Glitch In The Cloud" Sighting!
On the morning of 7th November 2014, a little after 10 am, a saucer-shaped craft with several bright lights was clearly visible over the Middleton area of Manchester. [2] So much so that John Hindley managed to capture a photograph of the visitor. The sighting created a quiet storm of debate in UFO circles.
35-year-old Hindley would later state that the object looked like a "glitch in the cloud". After he zoomed in on the picture, however, he believed it was clear it was a solid object. He would also state that he had sensed a strange "pulling sensation" when looking out of the third-floor window of his friend's house which forced him to look up. Even stranger, he would also state that when he looked at the pictures a little later, he would sense this same "pulling feeling", likening it to a "lunar pull". After half-an-hour or so, the object disappeared.
A year previously, on 8th December 2013, Duncan Kennedy would spot a strange object hovering over Strangeways prison [3] from the balcony of his Salford flat. He would manage to capture several moments of footage using his mobile phone. While the footage is not conclusive, it certainly doesn't appear to be a helicopter or airplane.
Another sighting occurred over Salford Precinct at around 10 pm on 21st April 2009. [4] The witness, known only as Rachel, would report the event. She would claim the object to be a "bright orange light, like a fire-ball moving at a steady pace". The sighting came amid several similar sightings in the area in the previous weeks.
UFO over Manchester, Nov. 2014
Encounter On The M5
On the evening of 29th June 2008 at 9:50 pm, 25-year-old Navy Engineer, Michael Madden, along with his colleague 22-year-old, Michael Casson, were driving along the M5 following a visit to Manchester when they witnessed a strange craft overhead. The disc-shaped object would hover for several moments, [5] glowing brightly, before it "zoomed off at incredible speed".
The witness would dismiss in advance any claims that what he saw was a standard aircraft. He would claim, aside from working with Royal Air Force aircraft on a regular basis, he grew up near to Manchester Airport, "so I know exactly what a plane looks and sounds like. This was definitely not a plane".
Only weeks before the sighting over the M5, on 7th June, three soldiers at Tern Hill Barracks would claim to have witnessed thirteen "rotating cubes" during their night patrol. Only hours later, a police helicopter would report a huge craft in the skies over Cardiff, only eighty miles away. They would report the craft as a huge "flying saucer-shaped" object. Furthermore, after the object almost collided with them they pursued it for some time before it disappeared.
Another sighting, three years earlier in July 2005, would see Peter Sotomski, along with four work colleagues, witness an "unusual object" speeding across the sky at 10 am, in the Eccles area of Manchester. Around five minutes after that object had vanished, a second object appeared, traveling the exact same direction.
Strange Activity Goes Back Decades!
Although these sightings have undoubtedly increased as the 2000s have gone on, recently declassified files show that several significant UFO encounters also took place in the Manchester region in the 1990s. [6]
For example, throughout August and September 1996, came a mini-wave of reports of fast-moving bright lights. Sightings would come from Middleton, Oldham, Stockport, Prestwich, Ramsbottom, Wilmslow, and Longsight areas of Greater Manchester. All witnesses would report how fast these lights moved. They would also speak of the stop-start, zig-zag type nature of their movements. This detail, found in many other UFO witness statements, would indicate something far different than a standard aircraft.
Perhaps one of the higher-profile of these sightings occurred on the evening of 6th January 1995 [7] when the pilots of a British Airways flight (Flight 5061) approached Manchester Airport arriving from Milan, Italy. Captain Roger Willis, along with co-pilot, Mark Stuart, would report an incident as they flew over the Pennines. A brightly lit oval-shaped craft screamed past the right-hand side of the plane. The object was only in sight for two, maybe three seconds.
The pilots enquired with Manchester Air Traffic Control as to any other aircraft in the area. The response came back that nothing was in their airspace. And more unnerving for the pilots, radar had not picked up any unknown objects. The MoD would "investigate" the sighting. According to their report in April 1996 due to no evidence other than the pilot's testimonies, they no longer had an interest in the case. The sighting remains unexplained.
The Little-Known Lyme Park Incident
It would appear sightings of strange objects in the Manchester region go back even further than the 1990s, with one particular incident that unfolded during Christmas 1975 being particularly intriguing. The account was passed to us by the witness himself and, aside from apparent newspaper coverage that is now missing from the archives (more on that later), this is the first time it has entered the public arena.
The witness in question, 54-year-old Dave Bradbury, was only a young child at the time, but on this particular night, he would witness something that he has never forgotten. On Christmas Night 1975, Bradbury, along with his brother and his uncle, were at Lyme Park in Disley, just outside of Manchester in order sled in the snow on the hilly area near the park's entrance. In fact, due to the snow that covered everywhere, they could see, there were plenty of other local youngsters who were doing likewise.
Bradbury would recall how there were two slopes at the park's entrance. One of these was younger children (which he, his brother, and his uncle were) and a second hill that was for teenagers and older youngsters. Each was awash with sleds and their occupants at between 5 and 6 pm on the night in question. However, all of their attention was about to be drawn to the dark, snow skies above.
Artist's impression of the incident
Suddenly, as if out of nowhere and "without any sound, a huge beam of light beamed down from about 200 feet" above them. Bradbury recalled how "everyone just stood and stared" up at this suddenly appearing and extremely strange light beam. The beam itself was perfectly straight with "very little" if any flare at all.
The light remained shining down on the scene below for several moments, causing the snow on the ground to shine in even more brilliant white. Then, as quickly as it came, the light suddenly went out. Several moments later, it appeared once more, only this time a little further down the valley before going out again once more.
At this point, Bradbury looked upwards to examine the sky. When he did so he could see a "black mass" that was most definitely something solid and that was moving extremely slowly, "almost a walking pace". A short time after noticing the bizarrely moving object, Bradbury, as well as his brother, and uncle, decided to quickly leave the park and make their way home.
Another Eyebrow Raising Detail!
Bradbury would add another intriguing detail in his report, however. Years later, for example, he looked to discover if there had been any newspaper reports of the encounter in the Manchester Evening News. Much to his surprise, the section for December 17th to December 31st was missing.
While this does not for one minute mean that there was even a report in one of the newspapers during this period, it is certainly a little eyebrow-raising that this particular section of dates is missing, and is certainly worth taking note of.
As Bradbury states in his report "there were plenty of other people who witnessed the event", adding that some of the (older kids) will be in their 60s now. With that in mind if you were a witness to the incident that night then please contact us with any information or details you might have.
There are certainly many similar accounts from across the decades that feature large, slow-moving crafts that shine strange beams of light to the ground, many of which we have examined before. Perhaps one of the most well-known is the Trancas incident in Argentina in 1963, during which multiple witnesses claimed a "solid beam of light" emerged from the underside of a large craft and reached directly to the ground. Another similar incident happened even earlier, this time in Merom, Indiana in 1957 when a similar "brilliant beam of blue light" hit the ground from the underside of a large, circular craft. There are many other cases we could highlight.
Other Similar Cases At The Same Time?
It might also be worth our time examining some very similar lesser-known UFO reports around the same time as the above account from around the world. [8] And while at least some of these cases suggest alien abduction encounters (something that Lyme Park incident clearly doesn't), they are still worthy of our time.
For example, several weeks earlier, on the 17th December 1975 in Sao Paulo, Brazil, 16-year-old Salles de Andrade was making his way home when an "intense beam of light" appeared from out of the sky directly overhead. The next thing he realized he awoke the following morning in a nearby thicket.
Perhaps one of the most intriguing – due to the similar details to the Lyme Park incident – occurred at around 10:30 pm on 31st December 1975 in Lisle, Illinois. [9] On the night in question, a husband and wife were driving to a relative's house for a New Year's Eve celebration in nearby Wheaton. As they did so, however, they would spot "a light suspended in the sky" over a field near the road.
They, along with several other road users would pull their car to the side of the road in order to get a better look. As they did so, they noticed the light appeared to "scan" the ground below them. Although the object appeared to make no noise, the witness did notice a "pulsated humming" sensation in the air. As they were driving away from the scene, the light suddenly went out, as if it had been turned off.
It might also be worth mentioning the more famous case of David Stephens, who claimed to have been the victim of alien abduction only two months before the Lyme Park case on 27th October 1975 in Oxford, Maine. He would claim that while driving on the night in question a "beam of light" shot to the ground from the underside of a strange craft that was "as big as a football" field (on that occasion the beam of light disabled their vehicle and possibly caused the witnesses to blackout).
Whether or not there is a connection between these accounts and the incident at Lyme Park in Manchester in 1975 is perhaps up for debate. Once more, though, if anyone reading this does happen to know more about that incident, and especially if they were one of the sledgers there that evening, please get in touch with us (see the contact details below).
Check out the short video below. It looks briefly at UFO sightings over Manchester.
Manchester's UFO sightings: Exploding sheep, almighty bangs and bright orbs all spotted last year, David Ottewell and Todd Fitzgerald, Manchester Evening News, February 20th, 2016 https://www.manchestereveningnews.co.uk/news/greater-manchester-news/manchester-ufo-sightings-exploding-sheep-10918824
Flying saucer uses sinister 'mind control' ray on Manchester man, Rob Waugh, Metro, November 17th, 2014 https://metro.co.uk/2014/11/17/flying-saucer-uses-sinister-mind-control-ray-on-manchester-man-4951595/
Is it a bird, is it a plane? Or is that a UFO hovering over Strangeways?, Mark Rochardson, Manchester Evening News, December 10th, 2013 https://www.manchestereveningnews.co.uk/news/greater-manchester-news/video-ufo-over-strangeways-filmed-6390066
UFO Spotted Over Salford Precinct, Salford Star http://www.salfordstar.com/article.asp?id=142
UFO Spotted By Navy Engineer Over M5 Motorway, Lucy Cockcroft, The Telegraph, July 1st 2008 https://www.telegraph.co.uk/news/newstopics/howaboutthat/2226748/UFOs-spotted-by-Navy-engineer-above-the-M5-motorway.html
Pilots experience close encounter with UFO in skies over Manchester, Richard Wheatstone, Manchester Evening News, July 12th, 2012 https://www.manchestereveningnews.co.uk/news/greater-manchester-news/pilots-experience-close-encounter-with-ufo-691001
UFO Had Near Miss With Boeing 737, The Telegraph, February 18th, 2010 https://www.telegraph.co.uk/news/newstopics/howaboutthat/ufo/7254652/UFO-had-near-miss-with-Boeing-737.html
The 1975 UFO Chronology, NICAP http://www.ignaciodarnaude.com/avistamientos_ovnis/Casos%20OVNI%201975,NICAP.htm
UFO Over Lisle, National UFO Reporting Center http://nuforc.org/webreports/075/S75513.html
The Louisiana Sightings – UFOs In The American Deep South The Persistent Mystery Of The Hessdalen Lights UFOs Over Illinois – The O'Hare, Tinley Park, And St. Clair Sightings The Bizarre Phantom Ghost Planes Of Derbyshire, England The Increasing Sightings Of UFOs On Live TV Broadcasts
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Colin Taylor says:
want to know more, would you like to see them and communicate with them ?


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The notion of ongoing updates as they originally appeared, though, raises the question of expansions. Blizzard has released seven expansions in all. And while later ones like Legion or Battle for Azeroth would feel out-of-place within the Classic framework, it stands to reason that some players may want to experience earlier expansions--such as The Burning Crusade or Wrath of the Lich King--in the context of World of Warcraft Classic. Blizzard isn't committing to this, but also hasn't ruled it out.
As someone who's leveled enough Alliance and Horde characters to fill multiple accounts, it remains to be seen whether replaying content I've seen many times before will keep my attention in the long term. But even the thought that it might suggests that for many people, this could represent a novel experience compared to the modern game, something at least worth a try.
So we asked ourselves, would it still be possible to deliver an authentic classic experience if we took our modern code, with all its back-end improvements and changes, and used it to process the Patch 1.12 game data? While that might seem counterintuitive, this would inherently include classic systems like skill ranks, old quests and terrain, talents, and so on, while later features like Transmog and Achievements would effectively not exist because they were entirely absent from the data. After weeks of R&D, experimentation, and prototyping, we were confident we could deliver the classic WoW content and gameplay without sacrificing the literally millions of hours put in to back-end development over the past 13 years.
As you have known, official site had merged three realms into one realm two weeks ago (June 6). Light's hope will launch new realm – Northdale this week (June 23). Official site is laying out plans for the timeline, and doing its utmost to ensure as smooth a launch as possible. Here mmogah.com will guide you to the new realm – Northdale's timeline.
Travel Time is what you will be doing the most of, thus talents or abilities that increase movement speed will likely have the highest impact on leveling speed.The more important concept is this: Shaving off seconds of downtime between pulls is equally valuable to shaving off seconds of In Combat Time. When you think about it this way, Damage Mitigation and Regenerative talents / abilities / stats have almost offensive properties and should potentially be valued equally to stats that increase damage.
14 Nov What we know about Classic so far Release date: Summer 2019. Patch version source: 1.12 - Drums of War ("because it represents the most complete version of the classic experience."). The client is based on a reverse-engineer of the 7.3.5 Legion client. Classic patch version: 1.13 Subscription cost: Included in the current Battle for Azeroth WoW subscription. No separate (classic only) subscription announced. ("We've talked about not wanting to split the community into "Classic" and "Live,") Release roll-out stages: Stage 1: Azuregos, Lord Kazzak, Dire Maul, Molten Core, Onyxia's Lair. Stage 2: Battlegrounds and PvP rewards, Zul'Gurub, Blackwing Lair. Stage 3: Ahn'Quiraj and the opening of the Gates of Ahn'Quiraj event, Tier 0.5, Silithus content, Green Dragons Stage 4: Naxxramas an the Scourge invasion world event. Servers available: (preliminary) - Estimated at 20+ on launch (BlizzCon demo time-period had 20) Additional info: - No LFR/LFD tool. - No in-game shop. - No WoW Tokens purchasable for 'Classic' gold. - No achievements. - No unified server Auction Houses (Alliance+Horde). - No flying. - No phasing or cross-realm tech. - Sharding is not confirmed, although it is a possibility to help with server load during the initial launch. (see post 11 below for clarification on phasing ≠ sharding) - Old character models will be used. - Updated graphics (textures and lighting), however 2004 graphics will be available in the options menu. - Character services are not currently planned, but services like Realm Transfers could be added in the future. - If Realm Transfers are ever added in Classic, there will be no transfers between Classic and Modern WoW servers. - Transmog of Classic WoW drops on Modern WoW characters will not be available. - No instant email (1 hour delay) - Auto-completion of names or quickly clearing a mailbox have been left in. ("someone could create an add-on to do the very same thing") - 16 debuff limit. ("We don't want to mess with the 1.12 data, we don't want to mess with balance") - Improved loot trading stays, no more exploitative ninja looting from trade windows. ("we felt that was worth retaining for classic rather than creating a volume of support tickets that were wholly unnecessary to the experience") - Energy regeneration (such as Rogues) will follow the old method (20 energy p/ 2 seconds) instead of the current 1 energy every tenth of a second. - Colour blind mode from current retail will be available. - Right click reporting from current retail will be available. - Battle.net Integration, download and chat through the Blizzard launcher. - There are no former members of Nostalrius developers working in the WoW Classic project. - There are no plans to change the class balancing of that time. Add-ons: - Currently there's no 100% concrete solution. There won't be a full roll-back to the 1.12 add-on API as doing so would allow nearly complete automation of combat decision making (Bots), however the modern API offers some additional functionality for creating social features that could also undermine the authentic Classic experience. Developers are looking for a middle ground using community and add-on creators feedback. Don't forget to upvote if you find this useful. I'll keep this updated as more info comes in. Sources: - Dev Blog: https://worldofwarcraft.com/en-us/news/21881587/dev-watercooler-world-of-warcraft-classic - Dev Blog: https://worldofwarcraft.com/en-us/news/22548005/dev-watercooler-inside-the-world-of-warcraft-classic-blizzcon-demo - Dev Blog: https://worldofwarcraft.com/en-gb/news/22646759 - Eurogamer: https://www.eurogamer.net/articles/2017-11-04-wow-classic-blizzard-answers-some-of-the-big-questions - Buffed.de: http://www.buffed.de/World-of-Warcraft-Spiel-42971/Specials/Classic-Interview-Server-Fraktionen-1268554/ - Blizzcon Classic panel: https://www.youtube.com/watch?v=hhKkP8LryYM - Gamestar.de: https://www.gamestar.de/artikel/world-of-warcraft-classic-leak-grafik-laesst-sich-per-knopfdruck-auf-retro-optik-umstellen,3336443.html - WoWHead: https://www.wowhead.com/news=288412/blizzcon-2018-wow-classic-interview-with-brian-birmingham-and-john-hight - Spidersweb.pl: https://www.spidersweb.pl/2018/11/world-of-warcraft-classic-blizzcon.htmlKallila11	14 Nov
Nov 15 Little Test on Class Quest Rewards Hey guys, I did a little test on certain class rewards to check whether they are adequate or not for the level they are obtainable. Paladin - Verigan's Fist is a famous weapon, added probably during the Naxx patch and lot of paladins remember lasting it for long time. Obtainable level is like 22, with party of same level players. And the Mace is equivalent to a level 26 Blue Mace. This means it's not bad! Warrior - Brutal Hauberk is infamous warrior chest. It is obtainable at level 20(as I remember), but it requires running a level 28+ dungeon. And it's mediocre - it compares to a level 24 blue, which is stupid. Whirlwind Axe is a famous warrior weapon which requires a nanny. :D You get level 30 and then pay people money or beg them to help you. This is not even doable with normal party until 35ish. Whirlwind Axe is equivalent to a 35 level Blue Axe, which is decent but still seems to be forcing it. Unless you hire a nanny, being social will probably help you get it at around 35-36 with similar level players. Warlock - Enchanted Gold Bloodrobe is pretty famous. I am not sure when it is exactly doable but is comparable to a level 35ish Robe. I think the verdict is that Paladin's Hammer is by far the best and the reason for it is that it was added later, at the end of vanilla, when Blizzard had more brains. :DHolylr1	Nov 15
We have no idea what implications this might have and whether or not it even indicates anything, since Patch 8.2 is still in testing and a Tuesday launch is more than unlikely due to Essence tuning and Azshara's Eternal Palace, which is supposedly coming shortly after launch. Blizzard said they wouldn't be delaying the new raid like they did with Battle of Dazar'alor.
Nov 15 You Absolutely Cannot Have Sharding This will not work well with a classic experience. Myself and the vast majority of my friends plan on coming back for classic. None of them want sharding. I know I don't speak for everyone but this mechanic will completely ruin the experience. Just voicing my opinion as I am incredibly excited about this project.Wurmknight82	Nov 15
Holy: Divine Favor - Your next Holy Light or Flash of Light is increased by 100%, costs no mana and is unable to be interrupted. Protection: Steed of Glory - Your Divine Steed lasts for an additional 2 sec. While active you become immune to movement impairing effects, and you knock back enemies that you move through. Retribution: Unbound Freedom - Blessing of Freedom also increases movement speed by 30%. Priest
Even though the guide was developed with a hunter, the guide can be followed by any class. Except you have to do your class's quests which aren't a whole lot. I do have full intention to make my guide friendly with all classes in the future by listing all of their steps as well. There will be a toggle that allows you to show which class's steps you want to see in the guide. But this is coming later.
That's not to say that everyone has an unrealistic vision of what vanilla WoW was like. There were already plenty of people on the WoW Classic forums pointing out that perceived bugs are just recreations of the original game. And as noted before, a flaw to one player is a key component of the original positive experience to another. WoW Classic will surely please plenty of purists in spades. But this goes to show that it won't be for everyone who has fond memories of the game circa 2006.
14 Nov Will I gimp my raid by playing Shadow Priest? I have a burning passion for shadow priest in vanilla and I mostly want to raid. I've been talking to some people I know and some of them say that they would never bring a shadow priest into raid and others say that they absolutely want 1 shadow priest in their raid group. Why the mixed reactions? From my understanding, shadow priests in classic are mainly brought to raids to buff the damage output of your warlocks with Shadow Weaving. How many warlocks would a raid need to make 1 shadow priest worth bringing over a mage for example, and am I gimping the raids DPS by taking up that raid spot?Luminé39	14 Nov
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Nov 15 Can both versions be played at the same time? I would play a lot of classic wow in between the queue times in modern wow. I have to wait for queues for raids, wait for M+, wait for pvp queues, wait for mount respawns. During the demo, I had to decide if I wanted to test out the classic demo, or obtain new items on my modern characters. I would have played a lot more classic wow during my downtime in modern wow, but there was an issue where my modern wow account would be logged out of the game, if my classic wow account demo logged in. Pretty please, I would really like if the classic account did not log out the modern wow account and both could be logged in at the same time.Hunterhir8	Nov 15
There's a whole list of websites that are trying to compile the working addons for the WoW Classic beta. The easiest one to parse through is Will It Classic. The site has a list of addons — including a search function — and has color-coded each one to signify whether or not it's working on the beta client. Keep in mind that the client runs on the Legion API, so there are a few semi-current addons that work without any tweaking by their creators.
If you're eager to claim your character name in WoW Classic, take note: we'll be opening character creation on Tuesday, August 13.** Players with an active subscription or game time on their account will be able to create up to three characters per World of Warcraft account. We'll have more information on realm names closer to launch, but rest assured—you'll have plenty of time to figure out your plans for realm domination!
Now that you know to loot everything (see tip #1), you'll have a lot of items in your bags. Any item that is white quality or greater may sell on the Auction House. How do you know what will sell well on the auction house? Trade goods and green quality (or better) items will almost always sell on the Auction House. See our Auction House guide (coming soon!) for more information.
Druid is one of the most versatile classes across all of World of Warcraft Classic. By picking Druid you will have plenty of options to choose from while leveling. However, in the end-game, most groups will expect you to heal, though, Feral and Balance druids are also very desirable for their Innervate and Rebirth abilities. Additionally, various animal forms will make traversing the world into quite an uncomplicated task.
Nov 15 Why was it "easy" for Nost, but hard for Bliz During Blizzcon we were told how challenging (at least that's how it came off) it was for Blizzard to create a working version of Classic... but Nostalrius, with no ties to Blizzard, was able to make a relatively bug free version of Vanilla? When I say "bug free" I know there was "a lot" of issues, but nothing an entire team at Blizzard couldn't fix. Wouldn't it be less work?Goró64	Nov 15
14 Nov Refund? Lawfully speaking, if Blizzard decides to back down on their promise of removing sharding after the population has stabilized, could you request a full refund? I mean false advertising is against the law, isn't it? I'm asking because I can tolerate sharding for the first few weeks because I can just not play during that time, but I have this nagging feeling that Blizzard isn't planning on removing it completely and will still continue to use sharding when the stress on the servers becomes too much, and I'm pretty sure I'm not alone on this matter.Spiike35	14 Nov
So committed, in fact, that modern WoW players are trying the beta and reporting what seem like bugs today but what were actually intended functionality 13 years ago. This became such a common occurrence that Blizzard publicly posted a list of known non-issues called the "WoW Classic 'Not a Bug' List." For example, hitboxes for the Tauren player race are much larger than those of other races. In a modern game, this would be seen as a serious balance issue (see: Apex Legends). But it's what vanilla WoW was like, so it has been faithfully reproduced.
Since WoW Classic server has been announced at Blizzcon 2017, there is not much info about the server revealed. It is known that the upcoming expansion Battle for Azeroth pre-order has been available at blizzard shop, and the system requirements of Mac and Windows has been unveiled Recently, Forbes has an interview with J. Allen Brack and Jeremy Feasel about the project and some of the vision that developers have.
Nov 13 WoW Classic BlizzCon Demo Pre-Download Hi everyone! We're incredibly excited for you all to get your hands on the WoW Classic BlizzCon demo next week, and to help make things as smooth as possible, we're making the client available to download for Virtual Ticket holders starting today. Over the next 24 hours, we'll be enabling the ability to download the WoW Classic demo through the Battle.net app for players who have purchased the BlizzCon Virtual Ticket, as well as standard BlizzCon ticket holders who have added their Virtual Goodies code to their Battle.net account. If you don't see the option to install the demo right away, don't worry – you'll still have plenty of time to download the client before the demo goes live during BlizzCon next week. We can't wait for you to get a peek at what we've been working on, and hope you enjoy this preview of what's to come!Ythisens156	Nov 13
Most people who have spent years playing massively multiplayer online games will tell you that there's something special about the first one you played, too—and WoW was the first for many people. You can become so swept up in the uniqueness of your first experience that you overlook many flaws. It's likely many look at WoW Classic with rose-colored glasses, just as many simply forgot which features were added when. And some of today's WoW players may be too young to have even played vanilla WoW as it once was.
Plenty of gameplay things have changed -- more on that in a minute -- but one thing almost immediately transformed the game for me. I was killing my fourth Kobold Vermin (sorry guys, I'm taking those candles) by auto-attacking it and waiting impatiently for my lone ability to light up, when it struck me: This was going to be slow. Really, really slow. And, after another minute, I realized that was okay.
14 Nov Classic was hard for casuals I think with all this comparing between difficulty in retail and classic going on, we should just say how it is/ was. Classic was hard for the casuals , while retail is difficult for the hardcore player. With this one sentence we can give both games the credit they deserve , without always having to do low blows against one game.Kappador63	14 Nov
Mounts also take up space in your bags, bags which will of course be much smaller. Every bag space counts. With no guild banks, and much smaller storage space, your bank alts are going to be essential. You'll need to remember to always post everything back to a bank alt, and to remember to get everything from the mail box to the Auction House. Which is only in Ironforge or Orgrimmar.
Why Skinning? Skinning is incredibly easy to level up while you are leveling your character. The leather that you skin will almost always sell on the Auction House (albeit not for much, but hey– it's free gold!). Even if you don't want to take the effort to sell the skins on the Auction House, you can simply vendor them for a significant amount of extra gold.
So, if you happen to have two good 1h weapons, and are Fury specced, don't be afraid to try out dual wielding. Some people swear by it, and I can see why. Getting miss/parry with 2h weapon is cancer, and having two weapon swings for two different chances at crit, can really help smooth out your damage and make it less random. If you're still skeptical, I'd suggest trying it out once you get Thrash Blade, or if you happen to have a Flurry Axe. With really sick 1h weapons, dual-wielding can definitely feel great.
It was the first time in a decade that I wasn't gunning for the end game, pillaging the beta test to determine the fastest way to level and get to the "good stuff," and tweaking my add-ons to skip as much content as I could to get there. I even read a quest or two, though I admit to using the option (still available, even in vanilla) to turn off the line-by-line scrolling of quest text.
This is the first faction exclusive class available only for the Alliance players. Paladins in World of Warcraft: Classic end-game were considered as one of the best single target healers around. However, other Paladin specs were not that popular. While Protection Paladins found their spot with tanking groups of mobs across the dungeons, Retribution Paladins weren't very popular in the end-game. However, Paladins were amazing levelers and World PvP participants due to their amazing utility skills and 'oh shit' buttons such as Lay on Hands or Bubble.
The vanilla WoW Horde leveling guide you see on this site was originally made back in 2006 by Joana (AKA Mancow, or FuriousPaul). The guides have been tweaked many times over the years to make things "faster". The leveling guides were made because of all the messages I got from people asking me how I was able to level up so quickly on new realms. I was first to level 60 on 7 different realms (3 with Mancow and 4 with Joana), even winning Blizzard's "First to Level 50" contest they held back in 2006.
You will see a resurgence of power leveling services, item trade services, and gold farming. Classic will have a fresh economy meaning for your average gold farmer time spent in classic is way more efficient. It will probably be worse than it was back in the day. Just look at the blizzard group finder on retail, littered with advertisements for m+ boosting websites. Disgusting. There will be so many gold farmers blizz probably won't be able to keep up. And this is what I truly fear because if the gold farmers start to win activision will step in and introduce wow token. And classic will die.
Nov 15 I Don't Have Time To Reach Rank 11-14 I Don't Have Time To Reach Rank 11-14 and this is perfectly ACCEPTABLE! I actually like the fact that rank 11-14 is extremely hard to get and time consuming. I don't care if it's not about skill, it is very RPG feeling in the fact that, the people who put in the most time and effort spilling the most enemy blood are the ones who get the best rewards. as somebody who will NEVER have a chance of getting those ranks and items because; 1. I do not have time to do it 2. even if I did have time I still wouldn't do it because I mentally could not farm BG's that many hours for 3 months I support the PvP system and think it is great, and acquiring the hugely powerful items is a big reward and a status symbol. in Classic WoW the game is less about YOU and more about your guild. even if you are not the person to get rank 14, or a Legendary item it still feels awesome when your guild mates get them because it will make your guild stronger. LOVE IT!Agonyy107	Nov 15
15 Nov (A)Elysium is Recruiting for Classic Greetings friends, I am the Owner of Elysium Gaming an multigaming and MMO organisation. I play WoW since Vanilla Beta and i am thrilled that we are gonna play again my most beloved game ever :) For that reason even though is early, we recruit people to join our ranks and start our journey together. We accept old and new players who want to play again or learn the game from the side of the Alliance. We are not elitists, we have patiance so we can teach and help those who need it and same time to prepare the guild for the end game. We are interested in PvE and PvP but also in every possible in game event. We are open to ideas and sugestions and after all we will deside all together how to run things.Thats the purpose we start now the recruiting,so we can gather as often as possible on our discord and discuss how we want our guild to be. All together we will deside about everything. I am experienced Guild Master and Raid Leader and i am sure i will be able to help so we can create something nice. If you are interested, please add me as friend Ariakan#2206 so we can discuss farther or join our discord channel https://discord.gg/rCy8sSd Thank youAriakán2	15 Nov
...but, in my experiences, I found dual wielding to be fine. But only if you're Fury. I found that having two weapon swings meant having twice as many chances to crit, which led to lots more Flurry procs. At level 50 with two blue 1h swords, my kill speed was just about the same as when I used an epic 2h axe. And I wasn't even specced into the offhand damage talent. If I got a good string of crits, I could smack mobs down in 15-20 seconds, and easily hit Bloodthirst every time it came off CD.
- Gold traders, both buyers and sellers are disliked everywhere, literary on every realm. But have no worries, we have developed very safe practices for trading the gold between ours and your accounts. If you require a specific way of delivery to you (AH, Face2Face, Mail, CoD) we can oblige to your request - just send us an e-mail right after your purchase (include your character name) and we will take care of the rest.
Over the 15 years since the launch of World of Warcraft, Blizzard has slowly sanded off some of Azeroth's rough edges. The world is still bustling with dangerous dungeons and harrowing raids, but these days it's a kinder, friendlier world. World of Warcraft Classic aims to fix that, to make Azeroth dangerous again--although it retains a few of the modern niceties.
15 Nov question about hunter So i saw this leveling guide for hunter in classic and it seems like u need some kind of addon to track ur auto shot. So my question is how did auto shot work back then? did u have to stand still to be able to shoot auto shots? and did like using arcane shot reset the timer of auto shot wich means if u are 1 sec from an auto shot but uses arcane instead u get new 3 sec (or whatever the wep speed is) before an auto shot is fired? thanksCirluica29	15 Nov
This option is better to use at level 40+. Higher level you are is better, more money you make then. All you do is farming dungeons or specific bosses. Here you kill a few birds with one stone: you get lots of experience (make sure you have all quests in your quest log, always ask your teammates to share) if you are still leveling; improve your current gear; and loads of loot (clothes, recipes, even crappy grey items selling for a lot to a vendor). If you are in a group, think about your groupmates if they need an item or not, don't roll need on everything.
An extremely rare herb, one is needed for each flask that an alchemist crafts. Only one black lotus is up at a time, and it can be found in Silithus (one north of AQ gates, one in crystal vale) and Winterspring (one at Mazthoril blue dragon area, and one south of the main road in the western Furblog area). Apparently also one in Eastern Plaguelands, I never saw it.


Your confidence levels decrease when you're ashamed of how your smile looks. Severely decayed teeth ruin your appearance and give others the impression that you aren't as healthy as you should be. At Every Smile Family Dentistry and Orthodontics, we understand that your smile plays an important role in first impressions. If you have a damaged tooth, Drs. Scott R. Lee and Adam J. Proctor recommend covering the imperfection with a custom-made dental crown.
A dental crown will enhance your appearance and restore oral health. After this procedure, you won't feel the need to conceal your smile. Instead, you'll want to show it off to everyone!
Should I Get a Dental Crown?
Dental crowns are used to restore fractured, decayed, broken, or weak teeth. Our teeth are strong, yet everyday wear and tear can easily ruin their integrity, which could result in frequent tooth pain, temperature sensitivity, or even tooth loss.
Dental crowns are used to finalize restorative procedures, such as root canal therapy. After Drs. Lee and Proctor completely remove the infected tooth pulp, a custom-made crown is placed over the repaired tooth to provide strength and protection.
If you have a single missing tooth, Drs. Lee and Proctor recommend a crown attached to a dental implant. Not only will this procedure correct the empty space, it will also replace the tooth root, which is responsible for stimulating bone.
Missing teeth are unattractive and negatively affect oral health. When a missing tooth isn't replaced, surrounding teeth can shift, creating additional dental issues. For single missing teeth, Drs. Lee and Proctor make a small incision in the gums and surgically place a titanium dental implant into viable jawbone.
Once the implant, which resembles a screw, has completely healed (four to six months), a dental crown is attached. This procedure replaces the entire tooth, rather than just the visible portion. Dental crowns are created to blend with surrounding teeth for a seamless replacement.
If the replacement tooth is seen when you smile, Drs. Lee and Proctor will recommend a porcelain crown. Porcelain is stain resistant and looks like a natural tooth. We will match the porcelain to the color of surrounding teeth so that your restoration doesn't stand out from the rest of your smile.
Patients who receive this procedure often experience an increase in confidence. A beautiful smile can do wonders for romantic and professional relationships. When you have all of your teeth, your oral health will remain intact, if you commit to a simple daily oral hygiene routine (twice daily brushing and flossing).
At Every Smile Family Dentistry and Orthodontics, dental crowns require two visits. At the first dental appointment, Drs. Lee and Proctor will examine how the damaged tooth impacts your smile. They will recommend the best material to fashion the crown from. Possible materials include porcelain, porcelain-fused-to-metal, and metal.
Porcelain crowns are esthetically pleasing and blend with natural teeth. Porcelain-fused-to-metal crowns are made from strong metal, but have a thin layer of porcelain over the metal, which creates a tooth-colored restoration, but is durable and sturdy. For back teeth, which aren't seen when you smile, we recommend metal crowns. While metal crowns don't resemble natural teeth, they are the strongest restoration possible. When you chew, your back teeth take on a lot of pressure, which makes metal crowns the ideal material.
After examining the damage, Drs. Lee and Proctor will prepare the tooth for the upcoming restoration. They will remove decay and bacteria, as well as a thin layer of enamel, which allows the crown to lay flat against the damaged tooth.
Next, they will take a dental impression of the affected tooth and the rest of your smile. The impression will be sent to a lab, where experienced technicians will make your permanent dental crown from the desired material. Before you leave this appointment, we will place a temporary crown over the damaged tooth. This will provide minimal protection while the permanent restorative device is created.
When you schedule your second dental visit, Drs. Lee and Proctor will remove the temporary device and attach your permanent crown. They will make sure the dental crown fits properly and is esthetically pleasing (unless it's a metal crown and not visible). The crown will be bonded over the repaired tooth with a special adhesive. With proper care, you can expect the dental crown to last 20-30 years.
After you receive this procedure, your smile will appear healthy and beautiful. Your oral health will be restored, as well as the integrity of the tooth.
If you need to repair a damaged tooth, call 480-732-7874 to schedule an appointment in Chandler, AZ. Drs. Lee and Proctor look forward to restoring your smile and confidence.