This research is designed to contribute on Korean marketing literature which lacks research on emphatic ability even though there are not only academic emphasis but also social needs on the topic. emphatic ability appears on some research in the area of sales management. However, those research is limited in that mixed terms have not clearly defined the concept, the focus is just on individual performance, and real world implication is lacking.
We subdivided the dimension of emphatic ability into two, both cognitive emphatic ability and affective emphatic ability.
Furthermore, we suggest cognitive and affective trust which mediates between emphatic ability and performance, and empirically test relationship between two emphatic ability variables and two trust variables since we strongly believe that cognitive and affective aspects fit better with interpersonal context.
Next, instead of using individual level performance of salesperson, this study extend the performance concept to encompass the relational performance between the firm and the customers. Whenever a customer face the sales person, the customer perceive the service is from the firm since ever time she gets the service, the sales person will be different person in real world.
Empirical results show all hypotheses on emphatic ability and trust are supported, and both cognitive and affective trust positively affect relational performance. We expect this research adds on understanding on how emphatic ability reinforce relationship between the firm and customers.


text:
Timmons, Lea Annette
October 9, 1953 - June 9, 2018
Lea Annette Timmons, born on October 9th 1953 in Cooperstown, New York to Anita and Roland Tamm passed away on June 9th 2018 in Dallas, Texas at the age of 64. Lea grew up in Valley Stream, New York and was raised with George Tamm, Kristina Tamm-Finnerud, Heidi Vertrees and Jon Tamm. Lea graduated from The University of Colorado at Boulder and owned her own business working as a medical recruiter for 30+ years. Lea moved to Dallas, TX in 2013 to be closer to her daughter.
Lea was very outgoing, spontaneous, free-spirited, intuitive, wildly creative and courageous, with a generous spirit that attracted the most loyal friends whom she was extremely grateful for. She was a deeply devoted and protective Mom to her daughter Brianna Timmons and her kitty cats, and loved walking along-side the women in her mastermind group while they achieved their goals and succeeded side-by-side. Lea remained very close to all four of her siblings and cherished the relationship she had with each one of them. She loved astrology, alternative healing modalities, yoga and meditation, interior decorating, traveling with her daughter and was an avid reader and foodie. She believed in love and beauty and constantly created both in her life.
A memorial service will be held on Saturday, June 16th at 2pm to honor Lea's life and celebrate the light and joy she brought to the world.
"I love you more".
Arrangements under the direction of:
2 replies on "Timmons, Lea Annette"
Annie Carlsson says:
My deepest condolences to Lea's loved ones. We were good friends in junior high school through early high school years. We often took the bus to Lynbrook to visit her grandmother "Mutzi". We got kicked out of "Civil Air Patrol" for giggling too much. Although I lost touch with her after high school, I never stopped thinking of her as a friend, I am do sorry for your loss.
Henry Goetze says:
A fellow classmate of the Central Class of 1971 bids farewell to beautiful and vibrant person. Hard to believe she has passed.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Which HTML CLASS definition is right solution? For now frameworks using for controls something like this
html
<{{html_tag}} class="ui-accordion ui-widget ui-helper-reset" />

css
.ui-accordion.ui-widget { {{style}} }
.ui-widget.ui-helper-reset { {{style}} }

For some time to come to me more logical this
html
<{{html_tag}} class="ui accordion widget helper reset" />

css

.ui.accordion.widget { {{style}} }
.ui.widget.helper.reset { {{style}} }

Does anyone have any pros and cons?

A: In your first example, because the framework abbreviation has been added as a prefix to every class specifically related to the framework:

*

*It allows you to clearly identify framework specific classes (vs what you may have added)

*It reduces the chance of collision with your own classes

*The classes are written to specifically relate to purpose, splitting them may abstract the meaning of the class from the purpose

A: As well as SW4's answer, it also has the benefit of using the following selectors to select any element with a class that contains or starts with ui-, respectively:
*[class|=ui] *[class^=ui-]

redpajama_set_name: RedPajamaStackExchange


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Sights on Sub-Sahara
Fragrance > Trends
September 25, 2018 Contact Author	Eddie Bulliqi, fragrance journalist
Remove Color, Haze and Imperfections From Your Flavors and Fragrances! — Gusmer Enterprises
Compounded by millennials' traditional values of diversity and inclusivity, there is an upswing of popularity for African heritage right now that places it upon a pedestal to which many feel it has never previously settled in America and Europe.
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When forecasting growth in developing fragrance markets, the continent of Africa and its constituent countries are largely ignored. Despite Africa's global influence, felt through a huge footprint (making up around 17% of today's world population with 1.2 billion people) and its rapidly developing economies (its fastest being Ethiopia, averaging +10% year on year over the last decade), it is rarely mentioned alongside Central America and Southeast Asia as a region with commercial potential for perfumery, and little is understood about its olfactory culture.a
Turbulent politics and consistent social instability in many countries across the continent cannot be ignored and go far in explaining why perfumery brands, producing traditionally superfluous commodities sought for comfort and beauty, have been nervous to invest in product programs in Africa. As reported by Rabobank Economic Research, even though southern Africa, the south of East Africa as well as Mauritius and Cape Verde stand out as more stable and democratic, overall, institutional quality in Sub-Saharan Africa remains weak.b Fragrantica only contains 14 African-based brands in its database, pointing as much to a lack of operational capacity in the region as to Africans overall being more interested in Western powerhouse names when it comes to luxury than local delicacies.
That said, China was in a similar consumer deficit when fragrance players ramped up operations in the country around ten years ago. Its culture did not have an olfactory legacy that lasted into the present day, and the stereotypical Chinese scent aesthetic of light and fresh fruity flowers executed with transparency had to be learned and adapted through trial and error by early brand investors such as Hermès. The success story in China was forged from growing consumer awareness over time, on the predicate that consumers' increased knowledge increases sales of luxury goods over long-term commercial cycles. A similar mindset should be applied to the perfumery business in Africa.
Positive Indicators
The biggest incentive to increase activity is the Gen Z-dominant demographic. The top 10 youngest countries in the world (with the highest population percentage under 18) all come from Africa, its median age being 19.4 measured against a global benchmark of 29.9.c With this in mind, it is not surprising that Sub-Saharan Africa accounts for nearly a tenth of the current global mobile subscriber base and is forecast to grow faster than every other region over the next five years, currently with 191 million active social media users across the continent (172 million of whom access social media through their mobile phone).d
China's growing middle class was one of the clearest signs that investment would remain stable in beauty goods and Africa shows similar prosperity in this regard. For example, Kenya's Social Class A (upper middle class) is projected to grow 28% till 2020, one of the highest forecasts in the world; in China, the Social Class A is only set to grow 4% over the same period.e In 2012, Africa's segment of high-net-worth individuals increased by 9.9%, the second-highest growth rate in the world after North America.f Economic advancement coupled with better funded higher quality education, particularly in Kenya, has meant that women now run 54% of the country's enterprises, indicative of high female buying power, a great sign for beauty and fragrance.g In stark contrast, just 24 of the 2018 Fortune 500 CEOs are women.h
In addition, unlike China, most living in Africa have experience with and enjoy fragrances. In a 2017 study carried out by research firm Kasi Insight, surveying 2600 respondents across Nigeria, Cameroon and Kenya,
"97 percent … in Nigeria wear perfume with 51 percent wearing perfume daily … 7 out 10 women wear perfume at least daily (compared to 3 out of 10 men). 85 percent of respondents re-apply [perfume] between 1 and 2 times a day. A small … percentage re-applies perfume 3 times a day."i
It is no coincidence that financial upturn is taking place at a time when films such as Black Panther achieve such great success at the global box office. For CNN's Chris Giles, the contemporary widespread celebration of African high culture traces its roots back to a movement called "Afrofuturism - a 20th-century cultural aesthetic that subverted sci-fi (a white-dominated genre) by placing black people front and center in futuristic worlds".j
Africa is trending right now and this has massive implications for any luxury product sector, fragrance included.
Compounded by millennials' traditional values of diversity and inclusivity, there is an upswing of popularity for African heritage right now that places it upon a pedestal to which many feel it has never previously settled in America and Europe; in the words of Jamie Broadnax, the founder of pop-culture site Black Girl Nerds, positive equal-footed narratives such as those found within Black Panther are triumphant for "not dealing with black pain, and black suffering, and black poverty," underlined by New York Times writer Carvell Wallace as "the usual topics of acclaimed movies about the black experience."k Africa is trending right now and this has massive implications for any luxury product sector, fragrance included.
Local Strategy with Worldwide Appeal
A global popularization of African creativity opens up a space for perfumery brands to feature African-generated narratives that generate interest around the world. Uché Pezard, founder and chief curate of Luxury Connect Africa, commented that "the rise of the Afrocentric movement is poised to change luxury business … Africans and those who have ties to the continent will be a significant force in the luxury market in the coming decades".l Corroborating Africa's growing influence on brand dynamics, Founder and CEO of R&R Luxury Valerie Obaze states that "African consumers are passionate about authentic products with original stories, especially if they originate in Africa. The made-in-Africa label is now being worn with pride all over Africa".m
In China, consumer insight groups invested heavily in cultural research for developing locally inspired scent stories to attract Chinese buyers with luxurious familiarity, and the rest of the world with exotic novelty - a strategy that worked with launches such as Armani' Privé's Pivoine Suzhou, Dior's Lucky, Atelier Cologne's Oolang Infini, Gucci's Bamboo and Hermès' Le Jardin de Monsieur Li. Exactly the same method can and should be applied to Africa, taking inspiration from the food, fashion, attitude, animals, landscape, and history to guide materials used and tone of voice. In a further similarity to China, however, there remains a challenge to entice local consumers away from mainstay conglomerate brand names and towards specialty perfumery. "Nigerians are very brand-conscious, so it's harder to sell an emerging brand … It can be tough at times as many clients just want to stick with the classic luxury brands," offered Jennifer Obayuwana, executive director of Polo Limited which specializes in luxury goods.n Futurizing the problem at hand may help to overcome it.
Within five years, luxury adopters will be predominantly made of up a Gen Z cohort, accounting for 40% of all consumers by 2020.o Dubbed 'philanthroteens,' and whilst not massively different from millennials' need for authenticity and transparency, one of the key themes driving Gen Z lifestyle choices and brand engagement is a desire to make a difference to the world starting with the community.p According to a 2017 survey by Cone Communications, 94% of Gen Z believe companies ought to address social and environmental issues.q If scent brands enter Africa with a clear cause and genuine message around wellbeing through scent, investing in philanthropic programs connected to African perfumery naturals, local education and sensory experiences for the community, they may end up with an African Gen Z movement that is the most passionate in the world about the savoir-faire of specialist perfumery.
This article	appeared in the October 2018 issue. Find more on this topic in the digital edition.
'The Value of Fragrance' Explored in IFRA Report
The Global Fragrances Market – Bringing Fragrances Closer to Consumers
4/29/2019, Clotilde Drapé, Research Analyst, Euromonitor International
This is What Your Zodiac Sign Smells Like...
Fragrance Futurology: 10 Ways Farm-to-Table Will Impact Perfume's Next Decade
4/29/2019, Eddie Bulliqi, Fragrance Journalilst
a For population figures, see http://www.worldometers.info/world-population/africa-population/; for Ethiopia's economy, see https://edition.cnn.com/2018/04/24/africa/africa-largest-economy/index.html
b https://economics.rabobank.com/publications/2015/december/sub-saharan-africa-politically-more-stable-but-still-fragile/
c For the top 10 see http://www.worldometers.info/world-population/africa-population/; for the median age see https://www.worldatlas.com/articles/the-youngest-populations-in-the-world.html
d http://www.hrpulse.co.za/editors-pick/236166-understanding-the-african-millennial-advice-for-small-business-owners-to-cater-to-todays-consumers
e http://beauty-africa.com/why-africa-cosmetics-beauty-industry/
f Ibid.
g https://www.howwemadeitinafrica.com/female-buying-power-on-the-rise-in-africa/18914/
h https://www.cnbc.com/2018/05/21/2018s-fortune-500-companies-have-just-24-female-ceos.html
i https://www.kasiinsight.com/single-post/2017/10/31/PERFUMES-FRAGRANCES-IN-AFRICA
j https://edition.cnn.com/2018/02/12/africa/genre-behind-black-panther-afrofuturism/index.html
k https://www.nytimes.com/2018/02/12/magazine/why-black-panther-is-a-defining-moment-for-black-america.html
l https://www.instagram.com/p/Bjl_5flB2J-/?taken-by=luxuryconnectafrica
m https://www.instagram.com/p/BhZNJa6hrwh/?taken-by=luxuryconnectafrica
n https://www.forbes.com/sites/declaneytan/2017/02/16/africa-gets-ready-for-its-first-luxury-e-commerce-platform/#7fb2a7d73115
o https://www.fastcompany.com/3045317/what-is-generation-z-and-what-does-it-want
p https://www.theguardian.com/voluntary-sector-network/2015/jun/19/philanthroteens-young-people-who-use-their-pocket-money-to-change-the-world
q https://www.forbes.com/sites/falonfatemi/2018/03/31/whats-your-strategy-for-attracting-generation-z/#61a88e716cad


For Dive One we swam out to the end of the point and dropped in on the Sujac which has split open at the keel and is laying on the reef in two large sections. There was a good size Giant Sea Bass (GSB) lurking in the kelp nearby. As we headed from the wreck West along the reef we encountered two more GSB's, one of which was absolutely huge.
A current was laying the kelp over and most strands had numerous Kelp Bass, Opal-eyes, and a few Sargos parked underneath. Blacksmiths were everywhere. Viz was 20-30+'.
Dive Three was the highlight of the day. We swam East from the steps for 30 yds and then dropped and angled Northeast away from the reef. Out there the kelp strands were bent over like long streamers in the wind. Each strand held all the fish that normal would be swimming around randomly, but to avoid the current they congregated in the eddies behind the fronds.
Suspended in the middle of the water column we could see the surface 50' above and the bottom 50' below. This was an enthralling moment of the dive; its what you can never explain adequately to non-divers.


text:
AI: Humans are have reached a place where scientific developments outpace moral understanding
indian cricket
Virat Kohli physically like a bull but was rested to avoid mental fatigue: Ravi Shastri
Virat Kohli did not play the Asia Cup which India won by beating Bangladesh in the final.
Oct 03, 2018 · 10:10 am
India coach Ravi Shastri revealed why Virat Kohli was rested from the recently concluded Asia Cup in UAE. Explaining the rest as necessary, Shastri said it was because of mental fatigue.
"Virat needed this rest. Physically he is a bull. You can't keep him out of the ground. And the thing with Virat is if he plays, then you know the level of intensity he brings. So it was a case of just mental fatigue, giving him a break, take your mind off cricket and then come back fresh," he was quoted as saying by Gulf News.
The India captain was not part of the team which lifted the Asia Cup title in UAE last week. Rohit Sharma led the team in Kohli's absence and when he was rested for the Super-4 match against Afghanistan, former India skipper MS Dhoni led the team.
Shastri also added that a similar process will be followed for other players especially the fast bowlers to keep them energetic.
"And we will have to do it with a lot of other players. You know like Bumah (Jasprit Bumrah), Bhuvi (Bhuvneshwar Kumar), we have to sustain them and keep them energetic," he added.
While Bhuvneshwar was rested for the Asia Cup, Bumrah was part of the squad but played only three games out of five.
Kohli returns to captain India for the two Test against West Indies with the first beginning in Rajkot on Friday.
Ravi Shastri
Cricket: Rishabh Pant shifted to Mumbai for surgery and further treament after car crash, say BCCI


In this day and age, it seems like everyone has a cell phone. All you have to do is look around at any busy street corner and there will probably be people on cell phones for miles. The question is, when should kids get them?
About 75% of 12-17 year olds in the United States own a mobile phone, up from 45% in 2004, according to an April study by the PEW Internet & American Life Project part of the PEW Research Center.
Children are getting cell phones at earlier ages, industrial experts say. The PEW study, for example, found that 58% of 12 year olds now have cell phones, up from 18% in 2004.
Clearly, the numbers of children with cell phones has been growing. The same study found that half of 12-17 year olds sent 50 text messages a day and text their friends more than they talk to them on the phone or even face-to-face. Consequently, with the growing numbers of young cell phone users, it may be a situation that your child will be trying to keep up with his or her friends versus making a true decision on the best time for a child to own a phone.
When any child is getting a phone, he or she clearly needs to be spoken to about the dangers of what is being said and done with the cell phone. Further, these children need to be told not to use their phones in order to have communication with adults or individuals that they and/or you do not know. More discussions should be had about what types of pictures your children are allowed to take and what the effect is of any photograph that may get sent.
Finally, any parent must look at his or her own use of cell phones. If parents are texting while driving, on their phone all the time, or constantly distracted by their phones, that is the message they are going to send to their children. Good, responsible use of the phone both in and outside of the car can have an impact on what your child sees concerning his or her own use.
Education with regular family discussions can make a big difference on how your child uses his or her phone and the effect all phone use has on you and them. Locators on the phone can be helpful in knowing where they are. Responsible use can make a child safe and even enhance communications between you and your child. This advanced communication can make a big difference in how your child develops into an even better adult.


Ed Phillips tells us about his Dad, who is really a dad's dad. Like we're talking all the dad jokes you could stand to grow up with.
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text:
Lilla Öratjärnen är en sjö i Falu kommun i Dalarna och ingår i . Sjön har en area på  kvadratkilometer och ligger  meter över havet. Sjön avvattnas av vattendraget Isalaån (Ryssjöån).

Delavrinningsområde
Lilla Öratjärnen ingår i det delavrinningsområde (674866-151424) som SMHI kallar för Förgrening. Medelhöjden är  meter över havet och ytan är  kvadratkilometer. Det finns inga avrinningsområden uppströms utan avrinningsområdet är högsta punkten. Isalaån (Ryssjöån) som avvattnar avrinningsområdet har biflödesordning 3, vilket innebär att vattnet flödar genom totalt 3 vattendrag innan det når havet efter  kilometer. Avrinningsområdet består mestadels av skog (77 procent). Avrinningsområdet har  kvadratkilometer vattenytor vilket ger det en sjöprocent på  procent.

Se även
 Lista över insjöar i Falu kommun

Källor

Externa länkar

Insjöar i Dalälvens avrinningsområde
Insjöar i Dalarna
Insjöar i Falu kommun

redpajama_set_name: RedPajamaWikipedia


text:
'Man Up,' 'Don't Be A Pussy' Labeled Offensive Language at Duke University
Claire E Healey - Grove City College •April 28, 2014
A new word-discouragement campaign at Duke University has labeled phrases such as "Man Up," "That's So Gay," and "Don't Be a Pussy" offensive language that "delegitimizes" homosexuality and oppresses and insults people.
But as the campaign has gained national popularity, its detractors have bristled at the effort, calling it a politically correct war on words that will stifle free speech and suggesting its true aim is to redefine terms to control public opinion and – ultimately – public policy.
In fact, the "You Don't Say" campaign creators have admitted as much.
"Language is a reflection of how we think about others and view the world," Jay Sullivan, a student leader of the campaign, tells Duke Today. "My goal is to…. help facilitate discussion about how language affects many social issues, from race to gender and sexuality."
The campaign consists of a series of black-and-white memes with students posing behind large pledges to avoid so-called offensive language.
"I don't say 'No Homo' because it delegitimizes love and sexual identities," says one.
"I don't say 'Man Up' because the strongest people I know have cried in front of me, regardless of their age, gender or sex," says another.
"I don't say 'Tranny' because it's insulting to transgender and genderqueer communities," adds a third meme.
Other banned words include "bitch," because it "insists feminism is inherently negative," "'fag,' because it only serves to hurt and oppress homosexual men," and "pussy," as it "implies that having a certain feature is indicative of being a coward."
The recently launched campaign has spread far and wide on social media and gained national attention in a variety of news reports. The effort is similar to the recent "Ban Bossy" campaign, and akin to other university student efforts that have banned the term "illegal immigrant" on campuses.
The campaign is a collaborative effort between a newly formed group at Duke University called Think Before You Talk and Blue Devils United, a Lesbian, Gay, Bisexual, Transgender and Queer student advocacy group.
The campaign has gained plenty of supporters, as well as detractors, whose reactions range from sarcastic to disgusted.
"I can't say anything about an individual person, because it might be construed as offensive to a larger group… even if I had no intention of offending a larger group," asks one Facebook post.
Others balk at the idea of being told how to choose their daily language.
"As a thinking individual, I don't and didn't need some children from Duke University admonishing me for 'thinking any gender is inferior,'" says another. "Do you see what they did there? 'Any gender.' Not 'either gender.' It's all about redefining terms, redefining life."
Some commenters on Facebook hardly took the campaign seriously at all: "There is nothing wrong with being a HOMO. We're all homos… homosapiens."
In an interview with The College Fix, Dr. Mark Hendrickson, economics professor at Grove City College, expressed concern for the direction and potential implications of the campaign, such as the idea of a possible enforcement mechanism.
He also questioned the discouragement of statements such as "man up."
"I'm a little concerned about censoring a phrase like 'man up'… a world without manliness, like a world without femininity… would be a pretty dismal place," Hendrickson said.
Hendrickson acknowledged the need for consideration of others when choosing one's language, but he observed that proponents of the campaign appear to have a narrow agenda.
He noted, especially with the impending graduation season, that similar tolerance is often not afforded to conservative campus speakers.
"With anybody advocating the banning of a certain word or phrase… would they be willing to publicly say, 'I promise in return to never hinder a speech by a political figure with whose political philosophy I disagree?" Hendrickson said.
College Fix contributor Claire E. Healey is a student at Grove City College.
IMAGES: Facebook screenshots


text:
Volume 9, December
Volume 9, June
Submit to Pharmaceutics Review for Pharmaceutics
Pharmaceutics Home
volume 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1
issue 1 2 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1
Pharmaceutics, Volume 9, Issue 3 (September 2017) – 15 articles
Cover Story (view full-size image): To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays, in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). The tip portions of MN completely dissolved in the rat skin within 5 min after application in vivo. After application of ALN(TIP)-MN in mice, the bioavailability of ALN was approximately 96 %. In addition, the decrease in growth plate was effectively suppressed by this efficient delivery of ALN in a rat model of osteoporosis. Furthermore, no skin irritation was observed after application of ALN(TIP)-MN. View the paper.
Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
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Publication Date Times Cited Times Viewed
All Sections None Nanomedicine and Nanotechnology Pharmaceutical Technology, Manufacturing and Devices Physical Pharmacy and Formulation Biopharmaceutics Drug Delivery and Controlled Release Pharmacokinetics and Pharmacodynamics Gene and Cell Therapy Drug Targeting and Design Biologics and Biosimilars Clinical Pharmaceutics
Augmented Renal Clearance in Critical Illness: An Important Consideration in Drug Dosing
Sherif Hanafy Mahmoud
Chen Shen
Pharmaceutics 2017, 9(3), 36; https://doi.org/10.3390/pharmaceutics9030036 - 16 Sep 2017
Cited by 73 | Viewed by 7858
Augmented renal clearance (ARC) is a manifestation of enhanced renal function seen in critically ill patients. The use of regular unadjusted doses of renally eliminated drugs in patients with ARC might lead to therapy failure. The purpose of this scoping review was to [...] Read more.
Augmented renal clearance (ARC) is a manifestation of enhanced renal function seen in critically ill patients. The use of regular unadjusted doses of renally eliminated drugs in patients with ARC might lead to therapy failure. The purpose of this scoping review was to provide and up-to-date summary of the available evidence pertaining to the phenomenon of ARC. A literature search of databases of available evidence in humans, with no language restriction, was conducted. Databases searched were MEDLINE (1946 to April 2017), EMBASE (1974 to April 2017) and the Cochrane Library (1999 to April 2017). A total of 57 records were included in the present review: 39 observational studies (25 prospective, 14 retrospective), 6 case reports/series and 12 conference abstracts. ARC has been reported to range from 14–80%. ARC is currently defined as an increased creatinine clearance of greater than 130 mL/min/1.73 m2 best measured by 8–24 h urine collection. Patients exhibiting ARC tend to be younger (<50 years old), of male gender, had a recent history of trauma, and had lower critical illness severity scores. Numerous studies have reported antimicrobials treatment failures when using standard dosing regimens in patients with ARC. In conclusion, ARC is an important phenomenon that might have significant impact on outcome in critically ill patients. Identifying patients at risk, using higher doses of renally eliminated drugs or use of non-renally eliminated alternatives might need to be considered in ICU patients with ARC. More research is needed to solidify dosing recommendations of various drugs in patients with ARC. Full article
(This article belongs to the Special Issue Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape)
Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative
Samaa Alrushaid
Casey L. Sayre
Jaime A. Yáñez
M. Laird Forrest
Sanjeewa N. Senadheera
Frank J. Burczynski
Raimar Löbenberg
Neal M. Davies
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox's bioavailability and tolerability. The purpose of this study was to characterize the pharmacokinetics and [...] Read more.
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox's bioavailability and tolerability. The purpose of this study was to characterize the pharmacokinetics and safety of Dox after intravenous (IV) and oral (PO) administration of DoxQ or Dox (10 mg/kg) and investigate the intestinal lymphatic delivery of Dox after PO DoxQ administration in male Sprague–Dawley rats. Drug concentrations in serum, urine, and lymph were quantified by HPLC with fluorescence detection. DoxQ intact IV showed a 5-fold increase in the area under the curve (AUC)—18.6 ± 1.98 compared to 3.97 ± 0.71 μg * h/mL after Dox—and a significant reduction in the volume of distribution (Vss): 0.138 ± 0.015 versus 6.35 ± 1.06 L/kg. The fraction excreted unchanged in urine (fe) of IV DoxQ and Dox was ~5% and ~11%, respectively. Cumulative amounts of Dox in the mesenteric lymph fluid after oral DoxQ were twice as high as Dox in a mesenteric lymph duct cannulation rat model. Oral DoxQ increased AUC of Dox by ~1.5-fold compared to after oral Dox. Concentrations of β-N-Acetylglucosaminidase (NAG) but not cardiac troponin (cTnI) were lower after IV DoxQ than Dox. DoxQ altered the pharmacokinetic disposition of Dox, improved its renal safety and oral bioavailability, and is in part transported through intestinal lymphatics. Full article
Comparative Pharmacokinetic Study for Linezolid and Two Novel Antibacterial Oxazolidinone Derivatives in Rabbits: Can Differences in the Pharmacokinetic Properties Explain the Discrepancies between Their In Vivo and In Vitro Antibacterial Activities?
Mohsen A. Hedaya
Vidhya Thomas
Mohamed E. Abdel-Hamid
Elijah O. Kehinde
Oludotun A. Phillips
This is a comparative pharmacokinetics study of linezolid (Lzd), and two novel oxazolidinone antibacterial agents—PH027 and PH051—in rabbits to determine if the discrepancy between the in vitro and in vivo activities of the novel compounds is due to pharmacokinetic factors. The pharmacokinetics after [...] Read more.
This is a comparative pharmacokinetics study of linezolid (Lzd), and two novel oxazolidinone antibacterial agents—PH027 and PH051—in rabbits to determine if the discrepancy between the in vitro and in vivo activities of the novel compounds is due to pharmacokinetic factors. The pharmacokinetics after IV and oral administration, plasma protein binding and tissue distribution for the three compounds were compared. The elimination half-lives were 52.4 ± 6.3, 68.7 ± 12.1 and 175 ± 46.1 min for Lzd, PH027 and PH051, respectively. The oral bioavailability for Lzd, PH027 and PH051 administered as suspension were 38.7%, 22.1% and 4.73%, which increased significantly when administered as microemulsion to 51.7%, 72.9% and 13.9%. The plasma protein binding were 32–34%, 37–38% and 90–91% for Lzd, PH027 and PH051. The tissue distribution for PH027 and PH051 in all investigated tissues were higher than that for Lzd. It can be concluded that the lower bioavailability of PH027 and PH051 compared to Lzd when administered as suspension is the main cause of their lower in vivo activity, despite their comparable in vitro activity. Differences in the other pharmacokinetic characteristics cannot explain the lower in vivo activity. The in vivo activity of the novel compounds should be re-evaluated using formulations with good oral bioavailability. Full article
Figure 6 Cont.
Transdermal Permeation of Drugs in Various Animal Species
Hiroaki Todo
Cited by 101 | Viewed by 7125
Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human skin to evaluate percutaneous absorption. Moreover, large [...] Read more.
Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human skin to evaluate percutaneous absorption. Moreover, large variations have been found among human skin specimens as a result of differences in age, race, and anatomical donor site. Animal skins are used to predict the in vivo human penetration/permeation of topically-applied chemicals. In the present review, skin characteristics, such as thickness of skin, lipid content, hair follicle density, and enzyme activity in each model are compared to human skin. In addition, intra- and inter-individual variation in animal models, permeation parameter correlation between animal models and human skin, and utilization of cultured human skin models are also descried. Pig, guinea pig, and hairless rat are generally selected for this purpose. Each animal model has advantages and weaknesses for utilization in in vitro skin permeation experiments. Understanding of skin permeation characteristics such as permeability coefficient (P), diffusivity (D), and partition coefficient (K) for each skin model would be necessary to obtain better correlations for animal models to human skin permeation. Full article
(This article belongs to the Special Issue Recent Technology of Transdermal and Topical Drug Delivery)
Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?
Yuejian Liu
Michael W. H. Coughtrie
Pharmaceutics 2017, 9(3), 32; https://doi.org/10.3390/pharmaceutics9030032 - 30 Aug 2017
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). They catalyze glucuronidation reactions in various aglycone substrates, contributing significantly to [...] Read more.
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). They catalyze glucuronidation reactions in various aglycone substrates, contributing significantly to the body's chemical defense mechanism. There has been controversy over the last 50 years in the UGT field with respect to the explanation for the phenomenon of latency: full UGT activity revealed by chemical or physical disruption of the microsomal membrane. Because latency can lead to inaccurate measurements of UGT activity in vitro, and subsequent underprediction of drug clearance in vivo, it is important to understand the mechanisms behind this phenomenon. Three major hypotheses have been advanced to explain UGT latency: compartmentation, conformation, and adenine nucleotide inhibition. In this review, we discuss the evidence behind each hypothesis in depth, and suggest some additional studies that may reveal more information on this intriguing phenomenon. Full article
Development and Evaluation of Topical Gabapentin Formulations
Christopher J. Martin
Natalie Alcock
Sarah Hiom
James C. Birchall
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In [...] Read more.
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. Full article
(This article belongs to the Special Issue Penetration Enhancement of Topical Formulations)
Pharmacokinetic Analysis of an Oral Multicomponent Joint Dietary Supplement (Phycox®) in Dogs
Stephanie E. Martinez
Ryan Lillico
Ted M. Lakowski
Steven A. Martinez
Despite the lack of safety, efficacy and pharmacokinetic (PK) studies, multicomponent dietary supplements (nutraceuticals) have become increasingly popular as primary or adjunct therapies for clinical osteoarthritis in veterinary medicine. Phycox® is a line of multicomponent joint support supplements marketed for joint health [...] Read more.
Despite the lack of safety, efficacy and pharmacokinetic (PK) studies, multicomponent dietary supplements (nutraceuticals) have become increasingly popular as primary or adjunct therapies for clinical osteoarthritis in veterinary medicine. Phycox® is a line of multicomponent joint support supplements marketed for joint health in dogs and horses. Many of the active constituents are recognized anti-inflammatory and antioxidant agents. Due to a lack of PK studies in the literature for the product, a pilot PK study of select constituents in Phycox® was performed in healthy dogs. Two novel methods of analysis were developed and validated for quantification of glucosamine and select polyphenols using liquid chromatography-tandem mass spectrometry. After a single oral (PO) administrated dose of Phycox®, a series of blood samples from dogs were collected for 24 h post-dose and analyzed for concentrations of glucosamine HCl, hesperetin, resveratrol and naringenin. Non-compartmental PK analyses were carried out. Glucosamine was detected up to 8 h post-dose with a Tmax of 2 h and Cmax of 9.69 μg/mL. The polyphenols were not found at detectable concentrations in serum samples. Co-administration of glucosamine in the Phycox® formulation may enhance the absorption of glucosamine as determined by comparison of glucosamine PK data in the literature. Full article
Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis
Hidemasa Katsumi
Yutaro Tanaka
Kaori Hitomi
Shu Liu
Ying-shu Quan
Fumio Kamiyama
Toshiyasu Sakane
Akira Yamamoto
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)–MN). We observed micron-scale pores in rat [...] Read more.
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)–MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)–MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study. The tip portions of MNs completely dissolved in the rat skin within 5 min after application in vivo. After application of ALN(TIP)–MN in mice, the plasma concentration of ALN rapidly increased, and the bioavailability of ALN was approximately 96%. In addition, the decrease in growth plate was effectively suppressed by this efficient delivery of ALN in a rat model of osteoporosis. Furthermore, no skin irritation was observed after application of ALN(TIP)–MN and subcutaneous injection of ALN, while mild skin irritation was induced by whole-ALN-loaded MN (ALN–MN)—in which ALN is contained in the whole of the micron-scale needles fabricated from hyaluronic acid—and intradermal injection of ALN. These findings indicate that ALN(TIP)–MN is a promising transdermal formulation for the treatment of osteoporosis without skin irritation. Full article
Theophylline-7β-d-Ribofuranoside (Theonosine), a New Theophylline Metabolite Generated in Human and Animal Lung Tissue
Daniel S. Sitar
James M. Bowen
Juan He
Angelo Tesoro
Michael Spino
While assessing the ability of mammalian lung tissue to metabolize theophylline, a new metabolite was isolated and characterized. The metabolite was produced by the microsomal fraction of lungs from several species, including rat, rabbit, dog, pig, sheep and human tissue. Metabolite production was [...] Read more.
While assessing the ability of mammalian lung tissue to metabolize theophylline, a new metabolite was isolated and characterized. The metabolite was produced by the microsomal fraction of lungs from several species, including rat, rabbit, dog, pig, sheep and human tissue. Metabolite production was blocked by boiling the microsomal tissue. This new metabolite, theophylline-7β-d-ribofuranoside (theonosine), was confirmed by several spectral methods and by comparison to an authentic synthetic compound. Tissue studies from rats, rabbits, dogs, and humans for cofactor involvement demonstrated an absolute requirement for NADP and enhanced metabolite production in the presence of magnesium ion. It remains to be demonstrated whether theonosine may contribute to the known pharmacological effects of theophylline. Full article
Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery
Akihiko Ono
Sayami Ito
Shun Sakagami
Hideo Asada
Mio Saito
Sachiko Hirobe
Naoki Okada
Cited by 27 | Viewed by 8725 | Correction
Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the dissolving MNs release the [...] Read more.
Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the dissolving MNs release the loaded vaccine antigen into the skin. To shorten skin application time for clinical practice, this study aims to develop novel faster-dissolving MNs. We designed two types of MNs made from a single thickening agent, carboxymethylcellulose (CMC) or hyaluronan (HN). Both CMC-MN and HN-MN completely dissolved in rat skin after a 5-min application. In pre-clinical studies, both MNs could demonstrably increase antigen-specific IgG levels after vaccination and prolong antigen deposition compared with conventional injections, and deliver antigens into resected human dermal tissue. In clinical research, we demonstrated that both MNs could reliably and safely puncture human skin without any significant skin irritation from transepidermal water loss measurements and ICDRG (International Contact Dermatitis Research Group) evaluation results. Full article
Supplementary material:
Supplementary File 1 (PDF, 486 KiB)
Open AccessFeature PaperArticle
A Possible Percutaneous Penetration Pathway That Should Be Considered
Ichiro Hatta
Noboru Ohta
Hiromitsu Nakazawa
Pharmaceutics 2017, 9(3), 26; https://doi.org/10.3390/pharmaceutics9030026 - 27 Jul 2017
The intercellular lipids in the stratum corneum form structures composed of ordered phases with orthorhombic and hexagonal hydrocarbon-chain packing structures and, in addition, a structure composed of a disordered fluid phase. Although the fluid phase plays an important role in percutaneous penetration, little [...] Read more.
The intercellular lipids in the stratum corneum form structures composed of ordered phases with orthorhombic and hexagonal hydrocarbon-chain packing structures and, in addition, a structure composed of a disordered fluid phase. Although the fluid phase plays an important role in percutaneous penetration, little attention has been paid to it in the literature thus far. Recently, a method to estimate the proportion of the fluid phase within the lipids of the stratum corneum was proposed and it was shown to reach about 80%. However, since that study assumed uniform extraction of the intercellular lipids from the stratum corneum, the analysis might give rise to an overestimation of the proportion of the lipids in the fluid phase. We developed a way to investigate the proportion of the lipids in the fluid phase by treating with ethanol, into which the lipids in the fluid phase might be dominantly dissolved. From the experiment we pointed out the possibility that the proportion of the lipids in the fluid phase reached more than 50% of the whole intercellular lipids. Therefore, the fluid-phase region in the intercellular lipid matrix should be taken into account when considering the percutaneous penetration mechanism. Full article
Veterinary Pharmaceutics: An Opportunity for Interprofessional Education in New Zealand?
Arlene McDowell
Rebekah Beard
Anna Brightmore
Lisa W. Lu
Amelia McKay
Maadhuri Mistry
Kate Owen
Emma Swan
Jessica Young
Globally pharmacists are becoming increasingly involved in veterinary medicine; however, little is known about the level of interest for pharmacists playing a larger role in animal treatment in New Zealand. A key stakeholder in any progression of pharmacists becoming more involved in the [...] Read more.
Globally pharmacists are becoming increasingly involved in veterinary medicine; however, little is known about the level of interest for pharmacists playing a larger role in animal treatment in New Zealand. A key stakeholder in any progression of pharmacists becoming more involved in the practice of veterinary pharmacy is the veterinary profession. The aim of this study was to investigate views of veterinarians and veterinary students on the role of pharmacists supporting veterinarians with advice on animal medicines. Open interviews were conducted with veterinarians in Dunedin, New Zealand. Veterinary students at Massey University completed an online survey. Most veterinarians do not have regular communication with pharmacists regarding animal care, but believe it may be beneficial. In order to support veterinarians, pharmacists would need further education in veterinary medicine. Veterinary students believe there is opportunity for collaboration between professions provided that pharmacists have a better working knowledge of animal treatment. Most of the veterinary students surveyed perceive a gap in their knowledge concerning animal medicines, specifically pharmacology and compounding. While there is support for pharmacists contributing to veterinary medicine, particularly in the area of pharmaceutics, this is currently limited in New Zealand due to a lack of specialized education opportunities. Full article
(This article belongs to the Special Issue Veterinary Medicine)
Multiple Functions of D-α-Tocopherol Polyethylene Glycol 1000 Succinate (TPGS) as Curcumin Nanoparticle Stabilizer: In Vivo Kinetic Profile and Anti-Ulcerative Colitis Analysis in Animal Model
Heni Rachmawati
Aditya Trias Pradana
Dewi Safitri
I Ketut Adnyana
This study was conducted to evaluate the potential benefit of particle reduction down to nanoscale on curcumin, a unique natural active compound facing therapeutic problems due to low solubility and permeability. In addition, the presence of TPGS as a surfactant for multiple functions [...] Read more.
This study was conducted to evaluate the potential benefit of particle reduction down to nanoscale on curcumin, a unique natural active compound facing therapeutic problems due to low solubility and permeability. In addition, the presence of TPGS as a surfactant for multiple functions on curcumin nanoparticle was addressed. Observation was focused on bioavailability enhancement after oral administration and local anti-inflammatory improvement after rectal dosing. Nanonization of curcumin was performed using an up-scalable top down method. Specific animal models were used to study the in vivo kinetic profile and the biological activity of curcumin nanoparticle, compared with curcumin powder. d-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-stabilized curcumin nanoparticle was prepared through homogenization with high pressure of the 1500 bar. An in vivo study was performed after oral administration of the preparations to male healthy Wistar rats, to monitor the plasma kinetic profile of curcumin. The biological activity study was conducted after rectal administration of the preparations in Wistar rats induced by 2,4,6-trinitrobenzene sulfonic acid to develop ulcerative colitis. The curcumin nanoparticle with a size of approximately 200 nm was successfully produced and revealed a better in vivo kinetic profile over the larger size of curcumin mixed with TPGS, with bioavailability (AUC0-∞) that was accounted for seven-fold. In addition, the TPGS-stabilized curcumin nanoparticle demonstrated a superior local anti-inflammatory effect in ulcerative colitis, indicated by the shifting of observed parameters close to the healthy status. The tremendously improved anti-inflammatory effect of the TPGS-stabilized curcumin nanoparticle was found with a very low dose. Reducing the particle size of curcumin down to ~200 nm with the presence of TPGS seems to be a promising approach to improving the therapeutic value of curcumin. Full article
Effect of Polymers on the Physicochemical Properties and Biological Performance of Fenoprofen Calcium Dihydrate-Triacetyl-β-Cyclodextrin Complex
Hussein O. Ammar
Tarek S. Makram
Shaimaa Mosallam
Background: Fenoprofen calcium dehydrate (FCD) is counted as a non-steroidal, anti-inflammatory, anti-arthritic drug. FCD is slightly water soluble. It is indicated for mild pain relief, where the suggested dosage is 200 mg orally every 4 to 6 h. Aim: Reduce dissolution efficiency, reach [...] Read more.
Background: Fenoprofen calcium dehydrate (FCD) is counted as a non-steroidal, anti-inflammatory, anti-arthritic drug. FCD is slightly water soluble. It is indicated for mild pain relief, where the suggested dosage is 200 mg orally every 4 to 6 h. Aim: Reduce dissolution efficiency, reach an extended therapeutic effect and reduce the frequency of the drug side effects. Method: Combination of the co-evaporated drug:triacetyl-β-cyclodextrin complex prepared in a ratio of 1:3 and either of two polymers—hydroxylpropylmethyl cellulose (HPMC) or ethyl cellulose (EC)—in the same formulation. In vitro dissolution studies were carried in simulated gastric (pH 1.2) and intestinal (pH 6.8) fluids, by using the USP dissolution tester (rotating paddle apparatus). The FCD in vitro release from EC/drug complex was markedly retarded. Interaction between fenoprofen, TA-β-CD, EC, HPMC in the solid state were confirmed by FT-IR, DSC, XRD and SEM. In vivo studies assessed the anti-inflammatory and analgesic activities and the results were compared with the market product Nalfosab® Capsules. Results: Remarkable inhibition of inflammation and nociception after 24 h was attained for EC/drug complex. Conclusions: EC/drug complex has a sustained effect due to high remaining amount after elapsing with remarkable inhibition of inflammation. Full article
Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailability
Viviana De Caro
Alessia Ajovalasit
Flavia Maria Sutera
Denise Murgia
Maria Antonietta Sabatino
Clelia Dispenza
Pharmaceutics 2017, 9(3), 22; https://doi.org/10.3390/pharmaceutics9030022 - 24 Jun 2017
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving [...] Read more.
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increases its solubility up to 28.36 mg/mL. Drug content, thickness, and weight uniformity of film were also evaluated. The measured Young's Modulus, yield strength, and relative elongation of break percentage (EB%) allowed for the classification of the drug-loaded film as an elastomer. Mucoadhesive strength tests showed that the force to detach film from mucosa grew exponentially with increasing contact time up to 7667 N/m2. FUR was quickly discharged from the film following a trend well fitted with the Weibull kinetic model. When applied on sublingual mucosa, the new formulation produced a massive drug flux in the systemic compartment. Overall, the proposed sublingual film enhances drug solubility and absorption, allowing for the prediction of a rapid onset of action and reproducible bioavailability in its clinical application. Full article
Displaying articles 1-15
Pharmaceutics, EISSN 1999-4923, Published by MDPI
https://www.mdpi.com/1999-4923/9/3


I'm sure you have already heard about the incredible power of guest posting. If it's well done, this strategy can do wonders for your traffic, ranking, and popularity. For those who are new to this amazing outreach method, or just want to improve their approach, I will explain in this article how to guest post effectively and have success.
What is a guest post and how does it help me?
First of all, let's see what a guest post is. As the name states, a guest post is an article published on someone else's blog or website. Therefore, you're a guest on their website. Now the following question would be "How does guest posting help me?". Well, that's a great question. Guest posting is one of the best ways to increase your traffic, gain authority, and reach the highest ranks in google searches.
Most of all, guest posting is about building relationships. After all, this is how influencers got where they are now. By networking and spreading their connections. This is the secret to blogger or influencer outreach. Building valuable and lasting relationships.
Now that you're up to speed on this topic, let's see which are the steps in guest posting. Are you ready to get going? Let's go.
Make a list of the websites on which you would like to guest post. This is the easiest part. After you've created your account on our platform, just go to your dashboard and search your keywords.
If you are into SEO then you may choose SEO category directly or simply search keywords like SEO, Search Engine Optimization, Blogging, Digital Marketing. If you would like to gust post on financial sector then you may choose Finance category or search for keywords like investments, finance, stocks, forex etc.
There are more than 1500 websites from 38 buzzing niches. The following step is to separate the authority sites from the average ones. Our tool offers information such as Alexa Rank, Facebook and Twitter followers, Domain Social Authority and Domain Authority in order for you to take the best decisions when creating your projects.
Now as I've said before, guest posting is about building relationships. That is why you cannot ask strangers for favors out of the blue. Especially if those strangers are famous top-tiers sought by everyone. You need to establish a connection first.
You are not the only one that tries to publish something on their website, so why should they choose you out of everyone? Building a relationship is easy because they are open to it. Make yourself visible by leaving relevant comments on their blog posts and communicating on social media.
You can even send them an email with a week or two before sending your pitch to tell them how much a certain post has inspired or helped you. Then just wait for them to respond. Don't spam them with too many emails.
For every website listed in Outreach.Buzz you have at least the email address and one of social media profiles so before sending them any guest posting request you should follow them on social media (simply click on twitter or facebook profile) and why not sending an email appreciating their work.
This is a very important step. Your pitch has to be next to perfect. If a pitch is poorly written you don't stand a chance. Follow the following guidelines for a successful pitch and you will surely win them over.
For more details, read our article on how to create the perfect pitch for outreach. Below is an example of a good pitch, even though the sender didn't research much before writing it.
What is the audience's knowledge level?
Are there any outdated articles that can be updated with useful information?
What kind of articles does the site's owner accept?
After you answer these questions, you will have a better picture of what works and what doesn't for that particular site.
Most influencers that accept guest posts offer specific guidelines which are their 10 commandments. You may be an experienced writer, but every blogger nourishes and nurtures his site and wants a certain consistency. So if you want to be a guest on their site, follow their rules. If you don't, you may waste your time with writing a 2000 words article that will eventually not be accepted. Also be open to suggestions. There's nothing wrong with a second opinion for the best outcome possible.
You can create different projects on our platform and assign them to team members. Separate the top-tiers from the average sites according to your goal. For those sites with a very pedigreed audience, you have to rise to their expectations.
Be sure to have at least 1500 words. A good article has to offer valuable information. Ar article with only 300 words is probably just an introduction. Guest posting is not just a way to get backlinks. It's a way to gain authority, traffic and establish a professional image. Therefore remember that your articles represent you, even though they are not on your site.
Be sure to insert in your guest post links to the owner's articles. This will definitely impress him or her and will pave the way for other future guest posts. This also shows that you are informed and appreciate their content. The perfect way to strengthen the relationship.
Once your post is out there, you will want to share it everywhere. Write on your blog about it, link to it, share it on every social page you own and send it to your subscribers. You want to be out there and gain as many readers as possible.
Don't abandon your post once it was published. You'll want people to engage by leaving comments and asking questions. If you want to gain an audience, be sure not to neglect those readers.
It makes sense. Networking goes both ways. Offer others the opportunity that was offered to you. You will also benefit from some good content and gain more readers and links. This is a way to help others grow and spread your connections.
Now that you know what guest posting is, how beneficial it is and how to do it, you're ready to go. If you don't have an account yet, create one and get free access to more than 1000 curated websites for 14 days.
Start connecting and spread your words everywhere. I'd love to hear about your experiences with guest posting and your recommendations. Leave a comment or send us a question and we'll be happy to talk.
'Nice collection of guest posting sites.Great work! thanks for sharing these!
Thanks for sharing that great article about Guest Posting service, I also have this article which is similar like as your. There is some more information that can help visitors to get more view. Can you link my article about Are you looking for Guest Post Service ? Then don't worry now. Guest Posting a great way to boost your website on google. Guest post will help you to cross your many competitors.
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On Monday, the School Board honored Student All-Stars from Timber Ridge School for their motivation, perseverance, growth, and school and community service.
Kaimana is truly an All Star here at Timber Ridge. She is motivated, inspiring, and a true leader. She is willing to help anyone who needs it, and works tirelessly to make Timber Ridge a better place. We are also extremely proud of Kaimana, great job!
Nakyah definitely deserves to be an All Star. She is a hard worker who has persevered through many challenges. She continues to be a top producer and learner while showing her classmates what it takes to be successful. She is a leader in the classroom academically and behaviorally. We are really proud of Nakyah!
Finley consistently displays an unlimited amount of effort, no matter what the situation. She navigates through difficult academic and social tasks with strength and grace. Her kindness and willingness to help others that may be struggling is inspiring!
Sam is an all star because of his incredible focus on school. Although learning comes easily for Sam, he does not let that be an excuse for doing the minimum. He is always listening, focusing, asking questions and volunteering his ideas. He is willing to persevere through tasks, even when he is struggling. Sam lets difficult tasks be a platform for improved understanding and personal growth. He also has a passion for sharing his thinking with others and wants to be sure that others understand his perspective; if he sees that other students don't understand him, he will explore new avenues of explanation. He is a model of what an engaged, focused team-player should be.


text:
package org.secureauth.sarestapi.queries;

import org.secureauth.sarestapi.resources.s;

import java.io.UnsupportedEncodingException;
import java.net.URLEncoder;

public class IDMQueries {

    /*
    User Creation
     */
    public static String queryUsers(String realm){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS);
        return stringBuilder.toString();
    }
    /*
    Users Profile
    */
    public static String queryUserProfile(String realm, String userName){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS).append(userName);
        return stringBuilder.toString();
    }

    /*
    Reset User Password
     */
    public static String queryUserResetPwd(String realm, String userName){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS).append(userName).append(s.APPLIANCE_IDM_USERS_PASSWD_RESET);
        return stringBuilder.toString();
    }

    /*
    User Self-Service Change Password
     */
    public static String queryUserChangePwd(String realm, String userName){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS).append(userName).append(s.APPLIANCE_IDM_USERS_PASSWD_CHANGE);
        return stringBuilder.toString();
    }

    /*
    Single User to Single Group
     */
    public static String queryUserToGroup(String realm, String userName, String groupId){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS).append(userName).append(s.APPLIANCE_IDM_USERS_GROUPS).append(encodeGroup(groupId));
        return stringBuilder.toString();
    }

    /*
    Single Group to Multiple Users
     */
    public static String queryGroupToUsers(String realm, String groupId){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_IDM_GROUPS).append(encodeGroup(groupId)).append("/users");
        return stringBuilder.toString();
    }

    /*
    Single Group to Single User
     */
    public static String queryGroupToUser(String realm, String userName, String groupId){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_IDM_GROUPS).append(encodeGroup(groupId)).append(s.APPLIANCE_IDM_USERS).append(userName);
        return stringBuilder.toString();
    }

    /*
    Single User to Multiple Groups
     */

    public static String queryUserToGroups(String realm, String userName){
        StringBuilder stringBuilder = new StringBuilder();
        stringBuilder.append(realm).append(s.APPLIANCE_USERS).append(userName).append(s.APPLIANCE_IDM_USERS_GROUPS);
        return stringBuilder.toString();
    }

    private static String encodeGroup(String groupId){
        String encodedGroupId = null;
        try{
            encodedGroupId = URLEncoder.encode(groupId,"UTF-8").replace("+", "%20");
        }catch(UnsupportedEncodingException uee){
            uee.printStackTrace();
        }
        return encodedGroupId;
    }
}

redpajama_set_name: RedPajamaGithub


text:
2022 Toyota Prius in Milford, CT
The 2022 Toyota Prius stick to similar features and specs apart from the new blacked-out Nightshade Edition. Do you want to know more about the 2022 Toyota Prius? At Colonial Toyota in Milford, CT, we will give you all information you need. Customers can start the pre-ordering process for the 2022 Toyota Prius by calling 203-286-5500.
The available trim levels of the 2022 Toyota Prius are L Eco, LE, XLE, LE-AWD-e, XLE AWD-e, Nightshade, Nightshade AWD-e, and Limited. It has a 1.8L Inline-4 engine with a hybrid system that churns out 121 horsepower and 105 lb-ft of torque. It is mated to a 2-speed E-CVT. It should go from 0-60mph in 9.8 seconds.
View Our Toyota Inventory
2021 Toyota C-HR LE
2022 Toyota Corolla Hatchback SE
2022 Toyota Prius Interior
The 2022 Toyota Prius has a spacious and practical cabin. The seats are designed to make passengers feel comfortable. The headroom for front row passengers is 39.4 inches, whereas the legroom is 42.2 inches. The rear row has headroom of 37.4 inches and legroom of 33.4 inches. It is comfortable for five passengers. The 2022 Toyota comes with a cargo space of 27.4 cubic feet. The upper trims like the Nightshade and the Limited have an 11.6-inch touchscreen system, whereas other trims have a 7-inch touchscreen. Other interior features of the 2022 Toyota Prius are:
Heated and power-adjustable front seats
6-speaker sound system
Multifunctioning steering wheel
2022 Toyota Prius Safety Features
The safety features of the 2022 Toyota Prius include:
Lane Departure Alert with Steering Assist
Pre-Collision System with Pedestrian Detection
Automatic Collision Notification
Lane Tracing Assist
For more details regarding the 2022 Toyota Prius, contact us at Colonial Toyota in Milford, CT. For further assistance, feel free to reach out. You can also check out our online inventory. We would love to hear from you!


WIN! A retro Everton shirt from your era of choice!
Latchford 1978. Sharp 1987. Ferguson 1995. There are players we remember all our lives. And there are football shirts that will forever hold those memories.
We've teamed up with Campo Retro, who do retro football with a difference. They connect with fans to find ideal nostalgic shirts inspired by moments, influenced by icons, born from a love of the beautiful game.
Campo Retro have a range of Everton retro shirts available, ranging from 1966-1995. And what's more, they'll print any name and number you want on the shirt from your memorable era.
We're delighted to bring you the opportunity to win a retro Everton shirt of your choice with the player from the history of the club of your choice on the back. You could even have your favourite player from one era in a Everton shirt from another era!
Take a look at the different Everton shirts Campo Retro have to offer, choose one, then tell us and Campo Retro which shirt you would choose using the form below! We´ll then select a winner at random to win their shirt!
The closing date for entries is Wednesday, 6th November 2013. Good luck!
Please note. Your entrant will go direct to Campo Retro, who may use your email for promotional purposes.


I've been listening to such an obscene amount of Morrissey lately. I am unsure if this is symptomatic of something else.
But I also covered this song in case you like things that are not quite as good as the original.


text:
Q: Using fgets() after other inputs I am kinda new to C programming and I am having trouble while making an exercise.
Here is my code:
    printf("Enter the First Name: ");
    scanf("%s", rd[input-1].firstName);

    printf("Enter the Last Name: ");
    scanf("%s", rd[input-1].lastName);

    printf("Enter the Phone Number: ");
    scanf("%d", &rd[input-1].phoneNum);

    printf("Enter the Address: ");

    fgets(rd[input-1].address, 100, stdin);

    dataWrite();
    printRecord(input-1);

where rd[n] is a structure array and the char[] space allocated for address field is 100.
I know that fgets() consumes "Enter"(\n) character. That's why when I enter phoneNum, fgets() is affected and I cannot get input for address field. Is there any other way to get a long address?
Problem solved:
I typed
     fgets(rd[input-1].address, 100, stdin);

twice. Now it works perfectly fine.

A: #include <stdio.h>

struct data
{
  char firstName[100];
  char lastName[100];
  char phoneNum[10];
  char address[100];
};

struct data rd[10];

void printRecord(int i)
{
  printf("\n");//ugh
  printf("fn: %s\n",rd[i].firstName);
  printf("ln: %s\n",rd[i].lastName);
  printf("pn: %s\n",rd[i].phoneNum);
  printf("addr: %s\n",rd[i].address);
}

int main(int argc, char** argv)
{
  int input=1;
  char buff[100];

  printf("Enter the First Name: ");
  //char * fgets ( char * str, int num, FILE * stream );
  fgets(buff, 100, stdin);
  sscanf(buff, "%s", rd[input-1].firstName);
  //Why "input-1"? keep it as just "input" and make sure it equals the correct value before entering this area

  printf("Enter the Last Name: ");
  fgets(buff, 100, stdin);
  sscanf(buff,"%s", rd[input-1].lastName);

  printf("Enter the Phone Number: ");
  fgets(buff, 100, stdin);
  //phoneNum is a string, not an integer, get it with a %s
  sscanf(buff,"%s", &rd[input-1].phoneNum);

  printf("Enter the Address: ");
  fgets(rd[input-1].address, 100, stdin);

  printRecord(input-1);

}


Matt Caulfield is an internationally recognised NLP trainer based in the UK, certified through the Society of NLP. He runs regular NLP trainings, both public and in house as well as one to one coaching. He writes regularly on his blog about NLP and related topics.
All Change Is Good, Good?
Due to family commitments I am taking a short break from running public courses. I am still offering one-to-one coaching and tuition and in-house training courses. Please contact me here to discuss them in more detail or to book.


SLOT-NANKAI has its roots and essense originally derived from a Japanese entrepreneurship in the middle of 20th century. Nankai Chemical engineering in Osaka, Japan, was started by an entrepreneur and the family of Sakaguchi.
The then Nankai had been used to making equipment for submarine until the end of the war. Back to the peace time, the company changed its product line to various Heat Exchangers and chemical reactors for many of the major Petro-chemical plant in Japan. The company gained good fame in their high quality control capability for many decades. clients such as Mitsubishi Heavy Industries, Mitsui Chemical, Toray Engineering, etc.
strength of SLOT-NANKAI in Thailand.


These are two bedroom condominiums with full kitchens. The off-lake units have jacuzzis in the master bedrooms.
We are offering various weeks from our inventory at reduced prices for a short period of time. If you are interested in purchasing a week that we have offered on our website, you must contact us while the week is listed below.
Red Week- Unit 313/Week 38- Offlake unit. Advertised selling price is $2,595.00 SPECIAL PURCHASE PRICE IS $1,595.00. This is a "Red" week so it would give you maximum trading power thru RCI.
White Week-Unit 109/Week 51- Offlake unit. CHRISTMAS WEEK!! Advertised selling price was $1,495.00. SPECIAL PURCHASE PRICE $995.00. This is a "White" week thru RCI.
Blue Week-Unit 102/Week 45- Lakeside unit. Advertised selling price was $995.00. SPECIAL PURCHASE PRICE $495.00.
"THESE ARE CASH PRICES - NO TRADES PLEASE"
Check this page often for your next great vacation!!


Expect 5°C daytime maximum temperatures in the shade with on average 3 hours of sunshine per day in Jan Mayen in August. Check more long-term weather averages for Jan Mayen in August before you book your next holiday to Jan Mayen in 2019/2020.
The August weather guide for Jan Mayen shows long term weather averages processed from data supplied by CRU (University of East Anglia), the Met Office & the Netherlands Meteorological Institute. Find out more about our data sources.
The average maximum daytime temperature in Jan Mayen in August is a cold 5°C (41°F). The average night-time temperature is usually a cold 1°C (34°F). There are usually 3 hours of bright sunshine each day, which represents 21% of the 15 hours of daylight.
Expect 68mm (2.7 inches) of rainfall across the whole of August with 16 days with some rain falling. Maximum UV levels will be low (2 UV index) at midday when the skies are clear.
The average sea temperature in and around Jan Mayen in August is 6°C (43°F).
Browse the sunrise & sunset times for Jan Mayen in August 2019. Select a month to view Jan Mayen sunrise & sunset times for the next twelve months.
What is the weather usually like in Jan Mayen in August?
How hot is Jan Mayen in August?
How sunny is Jan Mayen in August?
How wet is Jan Mayen in August?
How warm is the sea around Jan Mayen in August?


Perforating can be a nice profit margin booster, especially on regular re-prints. Then one day your customer calls to say that they're having problems running your perfed sheets through their gleaming, newly-installed Turbo-Kopy-Monster 7000. Or perhaps the call comes in after you deliver a job produced on your own brand new perforating equipment, an investment you hoped would deliver a better product. Or perhaps the dreaded call comes in even though nothing has changed (at least nothing obvious.) No matter what the scenario, (don't laugh...these are all true stories) the specter of a beautifully perfed and printed job coming back home to be re-worked or sorted begins to haunt you.
There is however, a simple, often overlooked strategy to help you steer clear of rejected perf jobs: run a small test batch before you run the full job, especially if you're new to perfing or it's a job for a new customer. There are countless variables in paper, machinery and environment and all it takes is one to be out of whack to ruin the job.
If you're perf is rotary, run a small batch and then flip a handful of sheets to perf from the other side of the sheet. Send both batches to your customer for testing. There are hundreds of copiers and printers on the market and each has a different path for the sheet to travel through the machine. What works on one copier may fail on another and in some cases, especially with the deep perfs typical of conventional folding and scoring machine perforators, success is a matter of having the perf blade hit the sheet on the other side.
Try different perf teeth configurations (teeth per inch, or tpi.) It's dangerous to assume for instance, that when a customer tells you he's always used a 17tpi perf, that your 17tpi will do the trick. It probably will, but if the ties (the space between the teeth) on your perf are substantially different from the customers, the strength of the perf will be affected. A perf job run on a platen die cutter could also behave differently than a perf job run on rotary equipment, even though the same perf configuration is used.
Take care to keep the perf as flat as possible. Jagged, deep perforations found in perf + counter knife combinations are more liable to jam up in laser printers than a flat perf such as those produced with the perf + anvil combination (pictured on the right) technology used in our fantastic Technifold Micro Perforator. A tip for flattening out a jagged perf on your folding machine: If you're perforating in the main parallel section, run the flat, perfed sheet through a right angle section, close all fold plates, and flatten it with pull out wheels (or use counter knives) running directly on the perf.
A perfed sheet that folds after perforating might need a different perf than a perfed sheet that just gets imprinted. If you're folding in-house it will be immediately evident when a perf fails…your folder will jam. So you stop and change the perf. But if you're applying the perf and then sending the entire job to your customer for him to fold at some point, the failure won't happen until all the damage has been done. It's hard to recover from this scenario.
Other variables which impact performance of the perforated sheet include grain direction, humidity, coatings, ink coverage and static. Be sure to consider these factors for further testing if the basic perf test tips above don't work. We've seen customers blame a "bad" perf for their problems when in fact static was the culprit.
Finally, if you are wondering what to do with a rejected job, try flattening the perf before you re-work the entire job. Use your folding machine (as described above), scoring machine or even a printing press to iron out the jagged perf and then re-test in the customer's printer. It could save you!
If you want to live dangerously, go skydiving or play the lottery with your paycheck, but don't send out that new perf job without a little advance testing. It's a simple, common sense strategy which takes very little time for you and your customer, yet the dividends can be huge when you consider the true costs of even a single rejected job.


text:
New Hero in an Old Villain?
By UWS Newsroom on January 22, 2020 • ( 1 Comment )
It has been over a Decade since the Hunger Games books entered our bookshelves, the popular book trilogy spawned 4 movies that launched several stars careers. Now the writer, Suzanne Collins is re-entering this world in the form of a Prequel about the trilogy's main Antagonist before he came to power. The Ballad of Songbirds and Snakes will focus on a young Pre-President Snow as he is forced to Mentor District 12's contestants of the Hunger Games.
Entertainment Weekly released a preview of the soon to be released Prequel, which followed a young Coriolanus Snow before he became the tyrant fans knew and loved (to hate). The entertainment outlet referred to the new Protagonist as "a teenager born to privilege but searching for something more, a far cry from the man we know he will become. Here, he's friendly. He's charming. And, for now anyway, he's a hero." The novel will hopefully focus on his descent into madness and rise to power. The book will also give more details and information on a world that fans have only ever seen a small portion of in the original series.
President Snow in the Original trilogy was written by Collins to be cold, calculating, and truly evil. In the books he is shown to take down any obstacle by any means necessary, whether this is by poisoning his fellow politicians or by sending his enemies into the 'Games'. The choice to have a young version of him be the so called 'hero' of the new books is certainly an interesting way to take the new series. However, fans of the book series were disappointed that the new prequel will not focus on a beloved Character's journey.
Joseph Cranor, a fan of the original book series had this to say about the recently announced prequel: "I think I'm mainly just a bit anxious about the whole thing. Personally, when I heard Suzanne Collins was writing a prequel, I was hoping it would be about some of the earlier games or centre on some of the other characters, like Haymitch or Mags."
Crandor also made an interesting point on the choice of a future dictator to be the new 'Hero' being quite problematic: "I really don't think the way to go about that was through centring the story on Snow. There are a lot of examples of writers giving sympathy to villains where audiences latch on to those characters' ideologies, and that's particularly dangerous in the case of a dictator like Snow."
While this is a good point as this book will most likely find a new fanbase in an impressionable, younger audience. Perhaps, by showing his rise to power and his thoughts may give an audience that relate top this character a few bad ideas. That being said, the author Suzanne Collins, has an excellent track record in condemning war and fascism by showing the actual politics that are involved. This new angle for the prequel could show the actual development of Snow's fascist ideaology, which could put this new book in line with the original blunt politics of the Hunger Games. At this point in time it is hard to say he exact message the prequel will put across.
The Ballad of Songbirds and Snakes will be released on the 19th of May, 2020.
Tagged as: books, Entertainment, UWS Newsroom, Young adult
A 'Long' Time Coming: Motherwell Striker scores first career hat-trick
How do Scottish football players find new clubs?
Elly McDonald says:
Having now read the prequel I love that Suzanne Collins took on the challenge of tracking the makings of a tyrant. She could have taken easier (and more appealing) paths but instead wrestles with the hub of it: how does evil arise?


Coinbase was launched in San Francisco, California. Coinbase, offered to users in over thirty countries as of 2017, is that the world's largest Bitcoin broker. Customers should purchase bitcoin with a connected checking account, SEPA transfer, Interac on-line, and plenty of additional payment ways.
Coinbase operates otherwise from traditional cryptocurrency exchanges. rather than requiring users to trade on a market, Coinbase directly sells cryptocurrency to users at a collection value (based off the current market price). this enables users to shop for their cryptocurrencies a lot of quickly than on an exchange. It additionally permits them to simply accept credit cards (in addition to bank transfers), something few exchanges provide. when users have verified their Coinbase accounts, they'll then purchase cryptocurrency instantly.
COINBASE LIVE SUPPORT NUMBER IS OBTAINABLE +1-877-753-8094 24/7.
We have our professional team to provide support for Coinbaserelated queries and we are always prepared to solve the problem as soon as possible. Users can contact Coinbase support number +1-877-753-8094 . Our proficient Coinbase support Number team will help you anytime from anywhere, you have to submit your registration details, user id and verified mobile number to get help.


text:
Longhouse Contracting
Experienced building contractor working and living in Haida Gwaii
Projects in Haida Gwaii
Earlier projects
By Longhouse Contracting
SGang Gwaay longhouse opening ceremony
The opening and blessing of the new Haida Gwaii Watchmen cabin on June 20th, 2016, at SGang Gwaay Llnagaay. This cabin was built to replace an older cabin that was built in the 1970's by one of the first Watchmen; Captain Gold.
Click here to watch SGang Gwaay longhouse opening
The cabin is located in Gwaii Haanas National Park Reserve, National Marine Conservation Area Reserve, and Haida Heritage Site. This protected site location is favoured by all Watchmen because it is one of the largest of all the abandoned villages located in Moresby Island. The historic village, which had at least 300 Haida, is now uninhabited with the exception of half the year by the Haida. These watchmen meet and greet all visitors to the site, and provide histories and information regarding this exceptional village.
There is a haunting presence from the ancestors spirits, and the feeling is more intense to those who are sensitive.
The site was occupied for at least 2,000 years by the Haida, and the numbers were varied during the hunting and gathering season. The winter season would have been utilized for building projects, ceremonies, and socialization with other villages. The numbers that occupied SGang Gwaay were significantly lowered by the smallpox infestation, and the survivors then moved to Skidegate to build a new home.
Mark Yaroshuk
V0T1S0
Contact Mark by email: longhouse@hgqci.org
Site design by Stephany Pryce Email: egypt319@gmail.com
Longhouse Images
Blog at WordPress.com. | The Designfolio Theme by Press Coders


text:
BlowUpRadio.com Newsletter 1/2/23
Follow us on Mastodon: https://mstdn.social/@BlowUpRadio
Lazlo will be broadcasting live with the following special programming:
Monday @ 7pm ET - BlowUpRadio.com Presents New NJ Music
Tuesday @ 7pm ET - Lazlo's Den Presents New Music
Listen here: http://player.live365.com/a42405?l
Every Monday read a new BlowUpRadio.com's New & Notable NJ Music: on New Jersey Stage: https://www.newjerseystage.com/content/author/lazlo
Latest Updates on BlowUpRadio.com
BlowUpRadio.com's New & Notable NJ Music: 12/26/22 (read it on New Jersey Stage)
Lazlo's Corner
"Say so long to the worst year of our lives... say hello to the best year of our lives" - from Joshua Van Ness's "Happy New Year" (stream it here: https://music.youtube.com/watch?v=Pv_DAx2AVjg)
2023! Let's do this!
The last few years have been a rollercoaster of ups & downs for me (and pretty much everyone I'm sure), but I have high hopes for 2023... that's my story and I'm sticking to it... for at least a few days... ah the heck with it... 2023 will probably be a rollercoaster too, hopefully more ups than downs.
The one true constant is BlowUpRadio.com will be here and so will tons of amazing music, and I have all of you to thank for that.
THANK YOU to the artists for making the incredible music that makes doing this station both possible and a joy!
THANK YOU to the listeners for enjoying this little station built around what I think is Good Music!
And a reminder, BlowUpRadio.com is preparing for its second annual benefit webathon for National Foundation For Transplants (the NFT that has value): https://transplants.org
The NFT saves lives by removing financial barriers that delay or prevent organ transplantation. One of the many people they have helped is Catherine Wacha (who is working with me to put this benefit together), who received a kidney transplant, that was necessary due to having Lupus.
The webathon will take place on March 4th & 5th, 2023
Like our other webathons, the plan is to do a compilation of previously unreleased original songs, and a webathon where musicians perform live (due to the ongoing pandemic performances will be done remotely via Skype or pre-recorded)
There are 2 ways for musicians to be involved:
1. I am looking for previously unreleased original songs (which can include acoustic or live versions of previously released songs, remixes, etc.) for this year's compilation. I ask that all songs be original (no covers) and that they remain exclusive to the compilation until June 1st, 2023 (3 months from the webathon). The songs will be due by February 17th, but if you have something ready, please feel free to send it now. Otherwise, if you think you can have something for the compilation, please let me know.
2. Looking for musicians to perform a 30 minute live set, via Skype (as with all our broadcasts, the video is for us to see each other, only the audio will be broadcast on air), for our webathon. We will definitely be broadcasting on March 4th, if enough people are interested we will do March 4th & March 5th. If you prefer, you can pre-record a set, but please make this an exclusive set (i.e. not a set livestreamed already)
From Catherine Wacha:
"The benefit we did in 2022 was a huge success and the folks at National Foundation for Transplants were incredibly grateful for not only the money we raised but the awareness we all brought to the organization. It is an honor to be able to help them out again."
If you are interested in being part of the webathon or have any questions, please let me know.
#SupportGoodMusic
This week on BlowUpRadio.com Presents New NJ Music we have new music from:
Project 18 featuring Dave Vargo - "In The Night" from "Pomona"
Omen and the Possum - "Walden" from "Omen and the Possum"
Cyphernaut - "Time Machine" from "Magpie EP"
Public Access - "Tell Me Your Secret" from "Embrace The Meteor"
Sonofdov - "Boy On Fire" from "Fangs"
Archangel - "Not Enough (ft. Dana Johann, Justin Benzino & Ruhi Gonen)" from "Inner Thoughts"
Jeff Devito - "Heart O' Mine" from "Sagittarius"
Dean Howey - "Turn Signal" from "Painting a Song: Season 2, Volume 11"
Nuisance Motel - "where it hurts" from "kosher 4 passover"
Joe Billy - "The Way Things Go" from "Fissure"
Weftin - "Wish" from "I Survived: The 27 Club B-Sides & Afterthoughts"
mr e - "q ball" from "drum and drummer"
Hello Whirled - "Imaginary Star" from "The Kids Don't Wanna Have Fun"
Loveseat Pete - "Polly (Live)" from "Live from the House"
veterinarian declan - "I Saw the Devil's Tree" from "Demo 16 - Hot Steaks"
BlowUpRadio.com Presents New NJ Music airs Monday @ 7pm ET
See playlist (with links to all the acts) here: https://blowupradio.com/den/2023/010223.html
This week on Lazlo's Den Presents New Music we have new music from:
Rejectionist Front - "What About the People" from "What About the People"
Black Paisley - "Human Nature" from "Human Nature"
Friends Of Our Youth - "The Search Master" from "That Was Then"
Christie Lenee - "Coming Alive" from "Coming Alive"
Gramercy Arms - "Yesterday's Girl" from "Yesterday's Girl"
The National Parks - "8th Wonder" from "8th Wonder"
Pearla - "With" from "Oh Glistening Onion, The Nighttime Is Coming"
The Science Of - "Fools" from "Moments"
Josh Hoyer & Soul Colossal - "Crazy Love" from "African Dreams"
Me Like Bees - "Animal" from "Disco Two Step"
Elsewhere - "Call You Out" from "Life...Is A Fraction"
Fucked Up - "Found" from "One Day"
Her Shadow - "So Close" from "The Ghost Love Chronicles"
Stellan Wahlstrom Drift Band - "Write Me Off" from "As Real As In A Dream"
Lazlo's Den Presents New Music airs Tuesday @ 7pm ET
That's all for this week folks.
www.BlowUpRadio.com
www.WhereNJRockLives.com
Click here to get the newsletter e-mailed to you each week


text:
Chips&Media Delivers its First AVS+ Core to Address the Growing Digital Set-top box Market in China
Chips&Media's latest CODA9 family supporting AVS+, CODA966 and CODA988, will be used in digital TV / STB SoCs for Chinese Satellite, Cable, IP and Terrestrial market
Seoul, Korea – August 1, 2013 – Chips&Media,Inc., - a leading company in silicon video Intellectual Property (IP) – announced today that it has delivered its CODA966 and CODA988, the first AVS+ enabled cores to a couple of leading semiconductor companies.
The new Video and Audio Coding standard of China (AVS+) is already being used on a trial basis for 3D satellite broadcasting in China. China Central Television (CCTV), a national TV station of China, officially announced that by the end of 2013 it will complete trials of AVS+ satellite broadcasting and begin HD broadcasting service. AVS+ will certainly be the dominant standard as one of the video format for China Satellite broadcasting as well as Terrestrial broadcasting.
CODA966 is a hardware codec IP that is capable of 1080p video encoding at 30fps and decoding at 60fps with almost all video industry standards including H.264, MVC, H.263, MPEG1/2/4, VC-1, Theora, VP8, RealVideo and AVS and now AVS+ as well as Google's image format WebP, which recently decided to be used by Facebook. CODA988 is also based on the same decoder platform with CODA966 and has strengthened high quality encoding capabilities up to 1080p60 with H.264 High Profile.
"We've been very pleased to announce the availability of AVS+, which will enhance our comprehensive portfolio of standards. We expect that the AVS+ will be a key requirement which impacts on the industry chain to meet the rapidly growing demand for 3DTV and High-Definition broadcasting in China," said Steve Kim, CEO of Chips&Media.
"It will definitely help us expand our existing capabilities in China and maximize opportunities for evolving China's set-top market."
About Chips&Media
Chips&Media,Inc. is a leading video IP provider based in Seoul, Korea(Republic of). Its advanced ultra-low power and high performance video technology has been chosen by more than 60 top-tiers based in US, Europe, Korea, Taiwan, China and Japan and has proven in silicon reaching 130 millions of units. For more information, please visit the company's web site at www.chipsnmedia.com
Contact Chips&Media
Fill out this form for contacting a Chips&Media representative.
Example: AVS+ IP Cores
Chips&Media Hot IP
HEVC/H.265 Main10 Profile Codec IP for UHD(4K 60fps)
HEVC/H.265 and VP9 Multi format Decoder for UHD(up to 8K) 4:2:0 10bit
5M pixel sensor support Image Signal Processing (ISP) IP
2MPixel sensor support Image Signal Processing(ISP) IP
See Chips&Media IP >>
Kilopass Anti-Fuse NVM OTP IP Designed into Montage Technology Next Generation Set-Top Box Chips Targeting Emerging Market Environments
INSIDE Secure and Digisoft.tv make set-top-box Digital Rights Management easy, with the launch of a PlayReady Encrypted Media Extension implementation
Novatek Selects Chips&Media's HD video technology for Set-top Box and DTV Platforms
Trident Microsystems and NXP to Combine Digital TV and Set-Top Box Businesses to Create Industry Leader in the Digital Home Market
Broadcom Demonstrates Industry's First Single-Chip High Definition Set-Top Box Solution With China AVS Support
See Chips&Media Latest News >>


Heya flocks! maybe you all will be aware of the Festival of Colors i mean Happy Holi 2016 festival . So Happy Holi to all of you. Hope these festive season bring bright future for you all. Here are some authentic Collection of Happy Holi Quotes Greetings For Family Friends.
You can also check and maybe you like it Holi SMS Greetings, Holi Celebration Images, Holi Celebration Pics India, Holi in India, Holi Songs Videos, Latest Holi Wishes Quotes,Happy holi sms in hindi, happy holi 2916 messages, happy holi text messages, happy holi 2016 quotes for friends, holi messages quotes, holi wishes for family & etc.
Enjoy the Indian festival of Holi with lot of fun.
Those will make your life even more colourful..
Hatho mai rang liye pichkari sang liye..
jhum jhum gayenge, holi yu manayenge..
Holi mai mile tmko total masti..
aur tmko mile sabka pyar aur dosti..