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Home / Social & Media / SubQ: Under the Skin / Cost of drug discovery – value for money?
By Giles Delaney*
Like orderly queuing at the post office or correctly using cutlery at a dinner party, universal and affordable medication is a hallmark of any advanced and civilised society.
But when it comes to finite sources of funding, the neat queue is showing signs of strain given the expanding range of ailments being tackled, especially 'orphan' indications that affect relatively few people.
Every year, the denizens of western countries are offered access to dozens of truly new drugs. According to the research house Pharmacare, 14,872 new drugs were in the pipeline in early 2017, 8% higher than the 13,718 drugs in 2016. These include launched drugs in additional development.
In turn, the 2016 figure was 11% higher than the 2015 tally. But the US Food & Drug Administration's (FDA's) Center for Drug Evaluation and Research approved only 46 'novel' drugs in 2017, which suggests that most of these treatments are reiterations or reformulations of old drugs (see chart below). Still – and in the words of FDA chief Dr Scott Gottlieb – "today, new medical breakthroughs are profoundly altering how we view and treat disease in a way that seemed inconceivable years ago."
Who pays?
So availability is not an issue, whether we're talking about old repurposed drugs or breakthrough treatments in areas such as immuno-oncology and gene therapies. But it's the 'affordable' aspect that is causing community disquiet, especially in the US where healthcare costs are galloping, and the complex public healthcare system is under economic pressure.
The reality is that developing a new treatment from scratch is horrendously expensive and the odds of commercial success are poor, necessitating sometimes sky-high list prices for new therapies. Added to this, the life cycle of drugs is decreasing, with so-called blockbusters superseded by fast-following rivals.
While estimates vary, it takes hundreds of millions of dollars to develop a major new drug, with a decade-plus development time between test tube tinkering and regulatory approval. According to the Centre for Medical Research International, in 2014 the average commercialisation success rate was 4.9%. In other words, more than 95% of compounds in the early toxicity dosing phase did not make it to market.
For the drugs that get to market, seven out of ten don't produce a return on investment for the owners.
Betting on R&D
For the early stage stuff, it would be 'safer' for a drug company to plonk its shareholders' funds on the black at the nearest casino. Fortunately they don't – as far as we're aware.
Driven by the need to replace their existing blockbuster drugs, big pharma companies are seriously upping their bets on research and development.
According to Endpoints News, the top 15 pharma companies spent US$98bn on R&D in 2017, a 45% uptick from US$67.2bn in 2016.
Four companies – Johnson & Johnson, Bristol Myers Squibb (BMS), GlaxoSmithKline (GSK) and Celgene – boosted spending by more than US$1 billion. As Endpoints notes, "that represents some big bets on late-stage efforts during an intense and growing rivalry to score bigger markets in oncology and other key disease focuses."
Orphan drugs do not stand alone
When it comes to R&D spending, orphan indications are being tackled on an unprecedented scale, leading to a re-focus from 'blockbusters' to 'niche busters'.
The FDA defines orphan indications as affecting fewer than 200,000 Americans. Collectively though, it's big business: a University of Massachusetts Amherst study estimates the FDA approved 554 orphan drugs between 1983 and 2015, and recognised 3,647 orphan indications. Since 1983 the FDA has run an orphan drug incentive program, offering drug companies incentives such as grants, tax breaks and a seven-year market exclusivity period (European regulators have a similar scheme).
Given these subsidies, it's easy to presume that orphan drugs are some sort of marginal exercise for the drug makers. But are they really? According to the uni's research, 22% of drugs sold in 2010 were for orphan indications – with an average value per drug of US$637m.
The research also contends the average return on investment for an orphan drug is 30% – almost double that of a normal drug. In some cases, the FDA is alleged to have granted approval to expensive drugs that have blocked eventual competition from cheaper imports.
Therein lies an ethical dilemma. While it's a hallmark of a civilised society to strive to treat all diseases, the orphan drugs are notoriously expensive because there are far fewer patients to recoup the R&D costs.
Inevitably, this will give rise to debate about who should bear the cost. For instance UK authorities in 2015 rejected approval and funding of a drug called Translana, used for the rare genetic condition Duchenne muscular dystrophy.
Despite questions around the drug's long-term efficacy, the £220,000 per annum sticker price for the treatment was later approved under a managed access scheme for five years, which means the NHS provides the drug for about 50 children.
The Translana approval followed a campaign by affected families including affected kids knocking on the door of Number 10 Downing Street. When it's a case of helping children to walk again, it's a hard case to ignore politically.
Avoiding the patent cliff
When internal R&D fails, big pharma is willing to spend big on speculative early-stage acquisitions to address the pending "patent cliff".
In February BMS paid US$1.85bn in cash and US$1.78bn in milestones for Nektar Therapeutics, which holds an early stage immuno-oncology drug called NKTR-214. Abbvie recently puzzled analysts by buying Stemcentrx for US$5.8bn (plus US$4bn of potential milestones). This investment is under a cloud because early survival cancer data for small-cell lung cancer has been underwhelming.
Judging from their reported profits the big pharma companies appear to be in clover, but growing pressures mean they have to ensure that some of this clover becomes hay for a more bitter winter.
One issue is that the average time to patent expiry for a drug in the US is 17 years, after which generic drug makers can compete (generics already account for 80% of drugs dispensed in the US).
Figure 1: CDER's Annual Novel Drug Approvals: 2008 - 2017 reproduced from CDER
Of course drug companies are not philanthropists and their investors bray for decent returns.
That means that the 5% of drugs which successfully reach the clinic need to generate returns that more than compensate for the development costs of the 'failed' 95%.The result, of course, is escalating drug prices, leading to pressure on public funders such as the UK National Health Service or Australia's Pharmaceutical Benefits Scheme to pony up for more and more drugs.
Ageing society's harsh choices
The harsh truth is the public purse cannot subsidise every 'useful' drug – especially the orphan ones – unless citizens are willing to cop a higher personal tax rate. For the drug companies it's hard to drop prices when the treatment cost several hundred million to develop and there are all those 'failed' drugs in the portfolio to justify.
As with the banks, big pharma never win sympathy in the court of public opinion because they report massive headline profits. Underpinning the push to develop new drugs is the salient reality that most western world populaces are getting older and also living longer.
Ageing baby boomers have tended to have had it their way in their personal and professional ways and they're less likely to put up with arthritic joints and dodgy hips in the same way their forebears did. Given the ratcheting drug R&D costs, the poor commercialisation strike rate and rising societal expectations, an expectation gap has emerged between what patients want and what they are willing (or able) to pay for.
But in any democratic society there's competition for scarce resources, and when it comes to funding affordable drugs something has to give. A 'cure' for the dilemma of drug economics versus societal expectations has never been further away.
But with 14,000 drugs in development, at least researchers are presenting the medical options for previously untreated patients in the first place.
*This is the second column in a regular series about the big issues that affect CLINUVEL and the broader biopharmaceutical sector.
Giles Delaney is an experienced business journalist, having worked for newspapers and magazines in the Asia Pacific for more than three decades. As a guest writer, Delaney retains full editorial freedom and his views are his own. Delaney is happy to answer readers' questions via mail@clinuvel.com. Answers will be posted on the CLINUVEL website.
1 SCENESSE® (afamelanotide 16mg) is approved in Europe as an orphan medicinal product for the prevention of phototoxicity in adult patients with EPP. Information on the product can be found on CLINUVEL's website at www.clinuvel.com.


Midburn Festival is a five-days long most broadcasted Israeli artistic event. The festival is the Israeli version of the 'Burning Man Festival' and takes place in the Negev Desert, near Sde Boker. The name of the festival consists of the Hebrew word for "desert" (מידבר midbar) and the English word "burn". The backdrop for the celebration constitutes itself as a powerful gathering spot for extravagant people raring to express themselves in various artistic ways. If you are into loud festivals and want to experience the most of the expressive art, you will definitely love this event.
The first Midburn was held in June, 2014, and attracted about 3,000 people. The latest editions of the festival drew in about 8,000 visitors. Midburn is not a music event so don't expect to see a big stage and lineup. It is more about art and self expression. The center of the camp has many large art displays and installations. A huge temple is burned on the final night. The main principles of Midburn are: Radical inclusion, Communal effort, Gifting, Civic responsibility, Decommodification, Leaving no trace, Radical self-reliance, Participation, and Radical self-expression. The best part of Midburn are parties organized by various groups on the camping grounds. They can be intimate or quite crowded, but always fun! There are many creative ideas and concepts to be discussed, but this place is recognized as the perfect place to socialize and seek inspiration.


The Cyber Pokédex is a handheld toy based on the Hoenn Pokédex, manufactured by Bandai.
There are two modes to the Cyber Pokédex: "Camera mode" allows users to capture 200 species of Pokémon, which they can look after using "Trainer mode".
This toy can be connected to the Cyber Poké Ball. Doing so allows a user to battle, trade and scan not only their own Pokémon, but the Pokémon of others as well. It can also be connected with another Cyber Pokédex.
Bandai recommends that the Cyber Pokédex is only used by children aged 4 and up. The toy requires two AAA batteries before it will function.
This page was last edited on 24 March 2016, at 20:14.


In a general sense David credits God with man's creation. But more specifically David declares that God was personally involved in David's creation. This would seem to present us with a contradiction which begs to be resolved. The Bible believing individual rightly extrapolates from their study of the Bible that God specifically and by His own hand created both Adam and Eve. Both scientifically and historically we rightly conclude that every individual human being after Adam and Eve is the product of procreation, rather than creation. We can further make consistent scientific observations and demonstrate with overwhelming empirical evidence that every human being currently in existence is a product of procreation.
How does this affect our understanding of what David wrote in Psalm 139? Because human procreation is wholly dependant on the physical attributes of the parents, and God created the original two parents through whom all people are derived (procreated), we can rightly ascertain that God indeed included the procreative model in man's physical design. This means that God gets the credit for both creation and procreation. God is worthy of worship!
This still does not explain David's claim that God did the forming of his unborn person. In this passage we accurate deduce that David proclaims God is not only aware of the procreative process, but He actively participates in the forming of each baby in the womb. David was talking specifically about himself and not every baby, but it would be an unreasonable conclusion that David was the only one God was involved in forming. God did not leave all others, besides David, to the procreative process as if it were some auto piloted scientific process.
To me this passage underscores, bolds, and highlights the truth that God deeply loves all of mankind. You could say there are three levels of depth of God's love for us. Firstly, Yahweh demonstrates His love for man in the initial creation of our parents Adam and Eve. Secondly, our God demonstrates His love for each individual by attending and overseeing their formation in the womb. Thirdly, our creator Yahweh demonstrates His love for us by Himself being born as a man and dying for our sins in order to reconcile us back into fellowship.
Because verse fourteen is true of David and every other individual ever born or yet to be born, we are priceless! We should never do harm to one other. Why? For two reasons. As Genesis 1:27 so clearly states God created man in His own image! Why would we do harm to something that reflects God? Think about it. We treat the Mona Lisa as a priceless work of art on display for all to see. At great expense the painting is secured with state of the art security equipment. Special lighting is used in order to not cause damage. Many have marveled over the similitude of a woman painted. And yet the object of their admiration is simply paint applied to canvas by an artist. Do we then value this inanimate two dimensional image of a woman more highly than an actual man or woman? A living, breathing man or woman possess a soul and is alive because a loving creator created them in His image. Created in God's image and purchase by the death of God's only Son!
You and I truly have been "fearfully and wonderfully made" by a loving Father. How different our world might be if everyone believed this truth. Would we have murder, abortion, euthanasia, physical abuse and war if we truly valued God's creation (man) and praised Him for it as the Psalmist David did?
Psalm 139 is beautiful poetry and a powerful truth giving us all just one more reason to worship Yahweh.
1 Reply to "Psalm 139:13-16"
No. We would not have war, abortion, euthanasia, and murder if mankind loved God's creation that He made in His image as they should. In fact man loves other things more than Gods created image of Himself typically. Very 😞 sad!


Home Chef Facilities Project Manager is responsible for providing leverage to the Sr. Facilities Manager and Plant Managers by effectively supporting the management of maintenance across all fulfillment centers. The Facilities Project Manager is responsible for driving results by establishing and holding accountability to high quality expectations for the overall care, sustainability, and safe work conditions of the fulfillment centers to support business needs.
Builds strong working relationships with all fulfillment center-based leaders including Maintenance Manager/Supervisors and continually strives to helps the plant leaders to grow and improve in their roles.
Sets clear performance targets with department leaders within the plant and discusses progress against the deadlines and established KPI's on a weekly basis.
Provides both positive and developmental feedback to plant department leaders.
Assists plant department leaders with problem solving issues impacting their KPI's or project deadlines.
Leads by example and embodies Home Chef values of Customer First, Best-in-Class Team, Ownership, Pursue Excellence, and Deliver Happiness.
Cultivates a culture centered around pride in the workplace, positive motivation, mutual respect, alignment, and accountability.
Drives strong communication between corporate and fulfillment center to gain buy in and alignment on initiatives.
Demonstrates willingness to work flexible hours and travel frequently to the fulfillment centers to provide regular on-site support, guidance, and drive accountability.
Supports the quality care of the facilities and employees by establishing and enforcing organizational standards.
Develops and maintains strong working relationship and acts as a supportive partner with the plant managers and Home Chef leadership.
Collaborates with the Sr. Facilities Manager, Plant Manager, and department leaders to establish a roadmap for success for each department based on individualized plant needs and trends identified based on observation and progress against weekly KPI's.
Maintains a pipeline of projects and goals while collaborating with plant leaders to establish realistic, aggressive timelines and drives accountability for the completion of established goals.
Experience with Safety, Maintenance, and Food Safety Policies and Procedures highly desirable.


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Hercules High and Mighty UK Slot Game
Hercules High and Mighty UK Slot
5 reels, 5 rows, an RTP of 96%, and 50 paylines. Hercules High & Mighty is one of Barcrest's more generous online UK slot game. With the chance to win up to 250,000 from the gameplay there's plenty to get excited about as you spin the reels on the slot which was released in late 2006.
The graphics may feel slightly dated, however, there is much, much more to Hercules High & Mighty than just visual appeal. For a start, the 5 x 5 reel grid gives you a super sized set of reels to work with. The larger size of the reels ensures that you have even more bet lines to work with than usual. With 50 different bet lines to choose from, you may be spoilt for choice, but that's one way of ensuring that you get practically constant wins.
Another great aspect of Hercules High & Mighty is the high return to player rate, sitting at just above the average rate, the online slot will offer you a RTP of 96%, and would any online slot game be complete without an offering of wild symbols, bonus symbols and free spins? Probably not. So, it's a good thing that Barcrest chose to include them with Hercules High & Mighty.
By this point, you might be wondering who Hercules is, and just how he got so high and mighty. Well, he just happens to be a divine icon in Greek mythology. The deity who was said to be the son of Zeus is one of the most famous Greek icons – whether if the stories which surround him are true or not. Legend has it, that Hercules was the strongest man who ever lived. We can't really put that to the test now, so, we'll just let him have the title and allow him to be our guide through Ancient Rome.
Hercules High & Mighty will invite you inside the stony colosseum, and the reels will hang from chains – we'll address the elephant in the room and state that this probably isn't the game for any graphic quality perfectionists, but those looking for the big wins should definitely read on!
In total, there are 10 different standard symbols you can expect to see pop up on the reels, all of them have been specially themed for the slot game.
In order of the highest paying symbols to the lowest these are the symbols which will ensure plenty of regular wins Zeus, Hera, Pegasus, Nemean Lion, Hydra, a 3-headed dog – if you were paying attention in history class, these were all fairly significant figures and creatures in Greek mythology. Anyway, these will be the highest paying symbols which will allow you to win anywhere between 250x and 75x your original stake amount when you are lucky enough to catch 5 of them in a winning line! For the lower value symbol, you will see spades, hearts, clubs and diamonds, all 4 of these symbols will only allow you to win a max of 50x your original stake amount – but that's much more generous than many other online slot games!
There may be relatively few frills with Hercules High & Mighty visually, and Barcrest may not have gone all out with the soundtrack either, but plenty of players have found their favourite online slot with Hercules High & Mighty - the very same could happen to you!
Barcrest have always had the ability to find the perfect balance between simplicity and immersive variance, their alchemic approach to knowing what players like to keep them spinning the reels is bordering on eerie. But on the plus side, that means their games, including Hercules High & Mighty are incredibly straight forward to play.
The first bonus feature is the wild, which will work in the usual way of acting as a substitute and helping you to create plenty of winning lines – this will work on each symbol aside from the scatter.
Every time you see five Zeus symbols appear, you will be instantly rewarded with a 250x multiplier while his wife will also be able to offer you a 200x multiplier. Yet, this isn't the only trick Zeus has up his sleeve – he is kind of magic after all, but he can also trigger the Mighty Reels bonus feature which allows the chains to lift up the reels and create even more pay lines. As if a 5 x 5 reel grid wasn't big enough already! Needless to say, the winning potential is huge here!
The betting ranges and features are yet another great aspect to Hercules High & Mighty. For a start, you get the incredibly wide betting range which stretches between 10p and £250 as your maximum stake amount. But you'll also get to reap the benefits of the big bet feature! You can choose to throw down £20, £30, and £50 on a bet. The higher the bet amount, the better the perk you will receive! If you do choose to play with the big bet feature activated, the return to player rate in Hercules High & Mighty could theoretically shoot up to 98%! Yet, the big bet feature isn't for everyone!
Finally, Hercules High & Mighty will offer some nice and classic free spins when you are lucky enough to find three, four, or five bonus symbols in a line, this will grant you with 8, 12 and 20 free spins respectively. You can expect Hercules to appear prominently in the free games too! There's also a very high chance that you will retrigger the free spins while you are spinning for free!
Hercules High and Mighty Developer - Barcrest
Anyone who has been spinning the reels for a while will know that Barcrest are an incredibly prominent name on UK slot casinos. They may be incredibly renown for their iconic online slot Rainbow Riches online slot, but there are also plenty of other online slot game titles which stand as a testament to Barcrest's creativity, ingenuity, and pragmatism.

redpajama_set_name: RedPajamaCommonCrawl


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Radical criminology began to appear on the criminological scene in the 1960s as criminologists began to question traditional criminology in light of political, social, and economic events occurring in the United States. Conflict over racial issues and the Vietnam war resulted in organized opposition to the state, including rioting and other forms of violence. The governmental, along with researchers and academics, sought ways to respond to and control these movements, which eventually led to rapid expansion of the criminal justice system.
Radical criminology may be referred to as Marxist, conflict, or critical criminology. The ideological perspectives defined in the early years of radical criminology continue to serve as a foundation for criminologists interested in anarchist, environmental, feminist, constitutive, cultural, peacemaking, restorative, and other branches of critical criminology. All branches of radical or critical criminology share concepts and principles centered on the distribution of power and ways in which the law protects the interests of the ruling class.
Radical or critical criminologists, many of whom were politically active during the 1960's, generally adhere to Marxist principles. While Marx did not specifically discuss crime, his writings focused on law, power, and social and economic control, each of which are important variables to consider in an examination of crime and justice. Radical criminologists argue that the law serves those with the power to translate their interests into public policy. Rather than accepting the premise of law as a product of consensus, radical criminologists define law as a set of rules defined and enforced by the state. Critical scholars argue that our criminal justice system neutralizes potential opposition to the state by targeting the actions of those who are most oppressed. In addition to controlling opposition, these laws often reproduce hierarchies that serve the interests of those in power.
Radical criminologists challenge mainstream criminology's focus on theoretical explanations of the causes of criminal behavior and the measurement of crime reported in the Uniform Crime Reports. The focus on common crimes and individual responsibility, leading to punishments intended to deter individuals from choosing crime, serves the state's interest in repression. Individual blame also diverts attention from structural models of causation and relieves those in power from accepting responsibility. Radicals argue that the discipline of criminology, the general public, and politicians focus on crime in the streets, allowing those in power to commit far greater criminal acts with little fear of retribution.
Radical criminologists also examine the processes through which deviance, criminal behavior, and state responses to crime are socially constructed. This examination provides insight into the ways state power is used to define challenges to authority. For example, behaviors that threaten the social, economic, and political order are labeled terrorist as well as criminal (Lynch and Groves, 1989). Different responses to criminal acts are facilitated when the state-controlled label of terrorist can be applied. Similarly, the focus on repeat offenders, and long prison terms, has centered on street crime rather than corporate or white-collar crime. This pattern also reinforces the perception that individuals, rather than institutions, are to blame for social problems. In effect, the powerful are able to exert social control on the masses while excluding their own acts and the criminal acts of those who serve powerful interests.
Radical criminology also examines the consequences of crime policies that prevent society from questioning the dehumanizing effects of our social institutions. The justice system is used to create a permanent underclass whose options are limited as a result of contact with the justice system. Thousands of men, particularly men of color, are kept out of the job market or trapped in the secondary market as they move through the seemly endless cycle of crime, prison, and recidivism. At the same time, the justice system creates millions of jobs.
Radical criminologists remain active within the American Society of Criminology (ASC), the Academy of Criminal Justice Sciences (ACJS), and other professional organizations. Radical criminology has evolved, and earned legitimacy within the wider discipline, due to the inclusion of radically oriented sessions at annual meetings and continued contributions to scholarly publications associated with these organizations. Formal recognition came when the Division of Critical Criminology was established by the ASC in 1990. This was followed in the late 1990's with the creation of the ACJS Critical Criminal Justice Section.
Currie, E. (1999). "Radical criminology or just criminology – Then, and now," Social Justice, 26.
Platt, T. (1988). "If we know, then we must fight: The origins of radical criminology in the U.S." Critical Sociology, 15(2).
Schwendinger, H. & Schwendinger, J. (1970). "Defenders of order or guardians of human rights?" Issues in Criminology, 5(2).


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Parental rights and the Taxpayer Supported Madison School District
September 24, 2019 Jim Zellmer
Logan Wroge:
Last school year, the district began using a 35-page guidance document on student gender identity, which is based on federal and state laws and School Board policies regarding anti-bullying and non-discrimination, Hohs said.
While the document was not voted on by the Madison School Board, members received updates on it when it was in development, she said.
The document covers topics like when a student's name can be changed in the district's student information system, the policy for restroom and changing area use, and how to communicate with the family of transgender and non-binary students about their identity.
The document states: "School staff shall not disclose any information that may reveal a student's gender identity to others, including parents or guardians and other school staff, unless legally required to do so or unless the student has authorized such disclosure."
David Blaska:
The things Madison public schools won't tell you.
They're teaching your children that they may not be boy or girl. Five and six years old. Gender confusion, et cetera. But don't tell mom or dad. Because the policy enacted one year ago was secret. Until now.
The Wisconsin Institute for Law and Liberty uncovered this policy, never before revealed to Madison voters or parents:
Related: The notion that parents inherently know what school is best for their kids is an example of conservative magical thinking."
Madison has long spent far more than most taxpayer supported K-12 school districts, between $18k and 20k per student, depending on the district documents reviewed.
"An emphasis on adult employment".
Yet, we have long tolerated disastrous reading results.
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4850 Mitchell Ave is a single family residence located in Riverside, CA 92505. Built in 1947, this property features 2 bedrooms, 1 bathroom, 7,405 sq ft lot, and 1,013 sq ft of living space. The estimated market value for 4850 Mitchell Ave is $356,000.
For the surrounding community of Riverside, CA 92505, the average sale price for similar homes to 4850 Mitchell Ave is $628,185. The nearby schools are very good and include La Sierra High, Myra Linn Elementary and Arizona Middle. The overall crime risk for this area is moderate with 12 criminal and sex offenders residing within 1 mile. The natural disaster risk for this area includes very high earthquake risk, low tornado risk, and minimal flood risk.
Secondary Owner:
The secondary owner (or borrower) is the person who signed the mortgage along with the primary owner. Even though this person is listed as the second on the loan, he/she still bears the same responsibility to ensure payments are made on time. In the event of a foreclosure, this person's credit will be affected along with the primary owner.
Property Details: 4850 Mitchell Ave
Subdivision: LA SIERRA GARDENS
Heating Type: YES
2012 $1,089 $39,625 $58,644 $98,269
4844 Mitchell Ave, Riverside, CA 92505
4875 Hiers Ave, Riverside, CA 92505
The average sales price of homes similar to 4850 Mitchell Ave is $628,185 ($564/sq.ft.)
4181 Stonewall Dr $800,000 12/31/2019 $679 1,178 sq.ft. 3 Bed, 2 Bath 0.9 mi away
3661 Florawood Ct $770,000 12/24/2019 $646 1,192 sq.ft. 3 Bed, 2 Bath 1.6 mi away
11120 Norwood Ave $586,000 12/12/2019 $563 1,040 sq.ft. 3 Bed, 1 Bath 0.4 mi away
5006 Bushnell Ave $564,000 12/12/2019 $635 888 sq.ft. 3 Bed, 1 Bath 0.2 mi away
10598 Pendleton St $800,000 12/11/2019 $679 1,178 sq.ft. 3 Bed, 2 Bath 1 mi away
3984 Polk St Unit A $554,000 12/09/2019 $457 1,211 sq.ft. 2 Bed, 2 Bath 1 mi away
5203 La Sierra Ave $370,000 11/27/2019 $340 1,087 sq.ft. 3 Bed, 2 Bath 0.5 mi away
3661 Upper Terrace Dr $800,000 11/27/2019 $671 1,192 sq.ft. 3 Bed, 2 Bath 1.6 mi away
4095 Penrod Dr $340,000 11/20/2019 $317 1,071 sq.ft. 3 Bed, 2 Bath 0.9 mi away
5353 Rose Ave $716,000 11/20/2019 $650 1,102 sq.ft. 3 Bed, 2 Bath 0.7 mi away
11015 Francisco Pl
10513 Magnolia Ave
10383 Gould St
3581 Polk St
4850 Mitchell Ave was built in 1947. The lot size is approximately 7,405 square feet.
A total of 10 properties had foreclosure filings in the 92505 zip code surrounding 4850 Mitchell Ave during the month of 12/2019, one in every 1,470 housing units. Riverside County, where 4850 Mitchell Ave, Riverside, CA 92505 is located, documented 514 properties with foreclosure filings during the month, a foreclosure rate of one in every 1,608 housing units. Statewide in California, one in every 2,744 housing units had a foreclosure filing in 12/2019, while one in every 2,541 had a foreclosure filing nationwide.


This company is very professional to work for. They provide to training and adequate direction of expectation. I am a new contractor for this company and have found them easy to work with.
I am recent to the company and have not had any issues with them. I am recent to the company and have not had any issues with them.
Love it, from the team's to the responsibilities!
None, everything is great as far as my concern.
Good product, ability to work on wide range of tasks and disciplines. Good location.
Very poor senior management, lack of engagement with staff. Snap decisions made at senior level without proper consultation or adequate planning. Unrealistic workload expectations. Inability to recruit staff and excessive staff turnover rate.
Avoid - there are plenty of better employers in the region.
Poor senior management. Very short term reactive planning. Autocratic, blame focused culture.
Trust your teams, listen to Dept heads, allow managers to manage.
"Arbeitsatmosphäre wie im frühen 20. Jahrhundert"
Schlechte Bezahlung, schlechtes Management, sehr bürokratische Organisation; die Arbeit hier ist sehr frustrierend, wenn man gerne etwas bewegen würde.
Moderne Managementkurse wären dringend angebracht.
Glassdoor has 6 General Dynamics European Land Systems reviews submitted anonymously by General Dynamics European Land Systems employees. Read employee reviews and ratings on Glassdoor to decide if General Dynamics European Land Systems is right for you.


Documentation of Vocalion Records derives primarily from Ross Laird's "Brunswick Records: A discography of recordings, 1916-1931" (Greenwood Press, 2001). See the ADP Brunswick Records Resources page for more information.
3/11/1925 New York, New York. 799 Seventh Avenue, Room no. 2 Unknown Master Vocalion 15120 10-in.
Discography of American Historical Recordings, s.v. "Vocalion matrix 525W-527W. Irish reels medley / McNamara Trio," accessed April 21, 2019, https://adp.library.ucsb.edu/index.php/matrix/detail/2000219341/525W-527W-Irish_reels_medley.
Vocalion matrix 525W-527W. Irish reels medley / McNamara Trio. (2019). In Discography of American Historical Recordings. Retrieved April 21, 2019, from https://adp.library.ucsb.edu/index.php/matrix/detail/2000219341/525W-527W-Irish_reels_medley.
"Vocalion matrix 525W-527W. Irish reels medley / McNamara Trio." Discography of American Historical Recordings. UC Santa Barbara Library, 2019. Web. 21 April 2019.


Want to ring in the new year with your very own private fireworks spectacular? Look no further than YouTube.
This New Year's Eve, for the first time, the City of Sydney's spectacular midnight fireworks show will be seen by millions around the world on Telstra's YouTube channel. Spectators everywhere will enjoy more than four hours of content, which this year has the creative input of Aussie pop princess Kylie Minogue. And as the clocks strike midnight, the iconic Sydney harbour will once again light up in what has become one of the most dramatic and dazzling events at the turn of every year.
Subscribe to youtube.com/telstracorp for a behind the scenes looks at this year's show, and tune in from 8:00pm AEST on 31 Dec to catch the action. The family fireworks show kicks off at 9:00pm, with the live stream playing continuously from six cameras all the way through to the grand finale at midnight. Whether you're at home with friends in Sydney, or at your desks elsewhere around the world, don't miss this New Year's spectacle.
A million views? You know what's cool? A billion views.
Today, a 34-year-old K-Pop artist made online video history when his viral video, Gangnam Style, smashed our records and became the first video ever to reach one billion views. Yup, that's right one BILLION views!
PSY's success is a great testament to the universal appeal of catchy music-- and er, great equine dance moves. In the past, music distribution was mostly regional. It was more difficult to learn about great artists from around the world. But with a global platform at their fingertips, people are now discovering and sharing amazing music from all over the planet, by artists like Brazilian Michel Teló and Belgian-Australian Gotye.
PSY was already big in Korea, but in 2012, he became a global celeb as Gangnam Style quickly spread from Seoul and the pacific to North America, South America, and Europe. It's been seen at least 1 million times in close to 75 countries, making it one of the most global music sensations ever!
From a one-thousand person flash mob in Jakarta to cover videos from Ai Weiwei and Mitt Romney, hundreds of thousands of parodies have been uploaded to YouTube, some of which have tens of millions of views. In fact, fan tributes to Gangnam Style are now being viewed 20 million times every single day.
PSY's own remix with Hyuna has 200 million views alone.
"Gangnam Style" was YouTube's top rising search of 2012 and on October 6th, we saw more than five million searches for "gangnam style" in a single day. Check out this video demonstrating some of our most popular YouTube searches this year.
For those interested in the business side: a number of assessments and projections have been posted claiming "Gangnam Style" has generated over $8.1 million in advertising deals, hit more than 2.9 million in song downloads since July, and achieved other incredible feats!
Since late last month, people have clicked to buy the track on iTunes over 600,000 times helping make PSY the first Korean artist ever to rank #1 on the U.S. iTunes chart and #1 in over 30 more countries.
Congratulations to PSY, the flash mobbers, K-Pop fans and people who love fun across the globe. Considering the Gangnam Style dance was the number one dance-related search on YouTube this year, you better make sure you brush up on your moves before New Year's Eve.
The kind of amazing creativity and unique connection between people all over the world that resulted in this one billion views is only possible with an incredible community of people we're so lucky to have on YouTube. And we can't wait to see what you'll come up with next!
Today's guest blogger is Mike Knapp, Chief Technology Officer and Co-Founder, Shoes of Prey, a Sydney-based ecommerce business where customers can design their own shoes.
Shoes of Prey can be summed-up in four words "design your perfect shoes". We're a Sydney-based ecommerce business where customers can design their own flats, heels, wedges, sandals or whatever takes your fancy.
When we established Shoes of Prey back in 2009, we wanted to combine our skills, passions and experience to build something remarkable — a product that would generate buzz and sell itself. Because our shoes are designed by our customers, they do just that. With over four trillion combinations of cutting-edge designs possible, our customers have designed tens of millions of their own shoes so far.
When we first started Shoes of Prey, we chose Google Apps for Business as our key technology solution. Much more than just email, we use the whole suite - docs, spreadsheets and presentations. One of the reasons we like using Google Apps is that it gives our staff the freedom and flexibility to work from home, allowing them to manage family commitments or just avoid the commute when the traffic turns nasty.
As we see it, as long as they have Internet access, our staff can be as productive at home or on the move as they are at work. Wherever they are, they have access to all the files and applications they need, and we have peace of mind that this data is secure thanks to Google's world-class backup and security systems.
We also use Google Apps with our production teams, public relations partners and our investors. This way we can share up-to-date documents in real time, anywhere, anytime without sweating about version control or transferring files by USB stick.
Another feature which supports our flexible work policy are Google Hangouts. Hangouts allow us to communicate face-to-face, whether we're across town or on the other side of the globe and help us maintain meaningful relationships with our production team and investors.
As an ecommerce business, it's paramount that our website is always secure and stable, so we also host our website on Google's App Engine. We can draw on Google's infrastructure to ensures our site responds seamlessly when there are sudden peaks in demand which happen around key shopping times like Christmas.
Although we're only a small team Google Apps allows us to "act big" by linking multiple email domain names to single accounts, we can use French, UK or generic domain suffixes to give a local feel to a global interaction. And administratively, the system is intuitive to use and new users, groups and aliases are set up in a matter of minutes.
Having started with three people and grown to about 40, Google Apps for Business has scaled with us. Although we don't know how many people we'll have on staff in future, we do know that it won't involve buying expensive servers or more IT upkeep. We'd recommend it to any SMB looking to set up and scale up big, as it has given us a lot of freedom and empowered us to work in new and innovative ways.
Editors note: Today's guest blogger is Mike Knapp, Chief Technology Officer and Co-Founder, Shoes of Prey, a Sydney-based ecommerce business where customers can design their own shoes.
While millions of people eagerly await Christmas Day, Santa and his elves are keeping busy at the North Pole. They're preparing presents, tuning up the sleigh, feeding the reindeer and, of course, checking the list (twice!) before they take flight on their trip around the world.
While we've been tracking Santa since 2004 with Google Earth, this year a team of dedicated Google Maps engineers built a new route algorithm to chart Santa's journey around the world on Christmas Eve. On his sleigh, arguably the fastest airborne vehicle in the world, Santa whips from city to city delivering presents to millions of homes. You'll be able to follow him on Google Maps and Google Earth, and get his stats starting at 2:00 a.m. PST Christmas Eve at google.com/santatracker.
In addition, with some help from developer elves, we've built a few other tools to help you track Santa from wherever you may be. Add the new Chrome extension or download the Android app to keep up with Santa from your smartphone or tablet. And to get the latest updates on his trip, follow Google Maps on Google+, Facebook and Twitter.
The Google Santa Tracker will launch on December 24, but the countdown to the journey starts now! Visit Santa's Village today to watch the countdown clock and join the elves and reindeer in their preparations. You can even ask Santa to call a friend or family member.
We hope you enjoy tracking Santa with us this year. And on behalf of everyone at Google — happy holidays!
Last week, ABC News 24 started streaming live on YouTube – a first in Australian news and television broadcasting. The launch means that all Australians can now watch ABC News 24 live from YouTube and can embed the live ABC News 24 stream within their Facebook or Twitter accounts. As a result, it's now much easier to share live events and breaking news coverage as it happens by putting the live link directly into your status update or tweet.
ABC News 24 can now push out updates from its Facebook and Twitter pages with live video attached - the live video content now accompanies the update that points to it. Visitors to ABC News' flagship YouTube channel have immediate access to live video alongside highlights from ABC News' broad range of coverage and programs on demand. Aussies will be able to choose to watch the up-to-date live coverage of ABC News 24 or access video-on-demand highlights to review their favourite news moments from the past, all from the same page.
While this technology is very early in its life (in beta) and the ABC's engagement with it is also new, we hope that Australians now find it easier to stay in touch with their news as they travel around the country during the summer holidays and beyond. Even if you're not at your TV, ABC News 24 is only one click away.
rewind and remember the videos, the entertainers, and the moments that captivated us in 2012.
This year, Korean Pop music transcended boundaries and took the world by storm. Cover songs, parodies, and "do-it-yourself" music videos from all genres entertained us in countries near and far. Aussies participated in conversations at a global scale, uploading videos to share ideas on everything from nonprofit campaigns, to political satire, to new and surprising voices and talents. And all over the world, we tuned in for the most up-to-date news footage of presidential elections, natural disasters and more.
2012 has been a big year for YouTube. Globally, we've been watching over 4 billion hours of video a month. Millions of creators are using YouTube channels to experiment with innovative forms of entertainment, explore their passions and interests, take creativity and pop culture to new levels. 2012's top trending videos showcase this creative ingenuity in ways we'd never before thought possible.
Posted by Kevin Allocca, YouTube trends manager, recently watched "Interactive Timeline: YouTube Rewind 2012"
It's that time of year again to pause, rewind and remember the videos, the entertainers, and the moments that captivated us in 2012.
oday, we're pleased to announce that Google Maps is here—rolling out across the world in the Apple App Store. It's designed from the ground up to combine the comprehensiveness and accuracy of Google Maps with an interface that makes finding what you're looking for faster and easier.
At the heart of this app is our constantly improving map of the world that includes detailed information for more than 80 million businesses and points of interest. Preview where you want to go with Street View and see inside places with Business Photos to decide on a table or see if it's better at the bar. To get you there, you've got voice-guided, turn-by-turn navigation, live traffic conditions to avoid the jams and if you want to use public transportation, find information for more than one million public transit stops.
The new Google Maps app is available for the iPhone and iPod Touch (4th gen) iOS 5.1 and higher, in more than 40 countries and 29 languages, including Chinese, Dutch, English, French, German, Italian, Japanese and Spanish. Please note some of the features mentioned in this post aren't available in all countries.
Visit the App Store today and download the new Google Maps app. We believe this delightful new experience is a great starting point—and we'll continue to improve Google Maps for you, every day.
From Korean pop stars to catastrophic weather events, lottery jackpots to life's burning questions, Google's annual Zeitgeist is a barometer for what captivated Aussies during 2012.
As 2012 comes to a close, it's time for our annual year-end Zeitgeist — an in-depth look at the "spirit of the times" in Australia as seen through the billions of searches on Google over the past year.
Gangnam Style danced its way to become Australia's top trending search for 2012, rising above searches for The Voice in the number two spot. Also in the top 10 was the year's biggest sporting spectacle, the Olympics, and a $100M jackpot put Oz Lotto on the list at number six.
Australians were asking quite existential questions this year, with how to love topping the 'how to' searches. Impressing someone and building relationships must be important for most Aussies with how to change, how to handstand and how to bulk all making the top 10. If bulking up on muscles didn't work to find that special someone, Australians turned to ask how to hypnotize (with a 'z'!).
The newsmakers of 2012 included Julian Assange, Felix Baumgartner, misogynist and the Diamond Jubilee. Concern for those in need drove interest in news stories about Hurricane Sandy, Melbourne Earthquake and Hawaii Tsunami. When earthly news was quiet, the science nerd within us turned to the skies to search for the Transit of Venus and NASA Curiosity's progress on Mars.
Whether we admit it or not, everyone likes a bit of celebrity gossip and domestically Lara Bingle beat Miranda Kerr to be Australia's top searched celebrity. Internationally, our fascination in Kate Middleton was only out-searched by our interest in Whitney Houston's death.
On our 2012 Zeitgeist website, you can explore the most popular and hottest trending search terms from all around the world. Happy Zeitgeisting!
To help achieve this goal, this year we funded nine universities and technical colleges across Australia and New Zealand to develop and deliver training to computer science teachers through our Computer Science for High School program.
With CS4HS, institutions such as Canterbury University and the University of Sydney have been able to provide professional development to hundreds of high school teachers. In turn those teachers have been able to return to classrooms and help ignite thousands of students passion for computer science.
The University of Queensland recently ran a 2 ½ day workshop with hands-on activities and seminars around programming and interaction design. Using the grant to pay for travel costs, organisers were able to fly in teachers from across regional Australia; a group that often miss out on training.
Next year, we want to build on those efforts by continuing to fund more Aussie and Kiwi universities and technical colleges. Applications are now open for our 2013 program and are open until February 16, 2013. To qualify, you must work for an accredited university, college or technical school in one of the qualifying regions.
If you're not a university faculty member, but still want to be involved, reach out to a local area university and encourage your computer science chairperson to apply. There are also some great classroom resources on our K-12 educators page.
Increasing the number of computer science graduates is something that governments and companies globally are focusing on to drive innovation and economic growth.
Publishers are the lifeblood of the Internet, and we're committed to helping you grow your businesses. Last year alone, we shared $6.5 billion with our AdSense publishers. We also invest immense amounts of time and millions of dollars in systems (including sophisticated algorithms and human reviews) that keep bad ads from appearing on your sites and prevent advertisers from being fraudulently charged for bad clicks. When everything is working well, advertisers trust our network and continue to invest in it, which generates revenue for you the publisher, ultimately funding the free content users love.
But we've also heard the stories: publishers finding their accounts suspended or even disabled for "invalid activity" without a clear understanding of why or how to fix it. We know this can be an intensely frustrating, even scary experience. So why does this happen?
We've given publishers tools to submit more informative appeals via a new form, which may help resolve issues more quickly.
We're providing more details on invalid activity's causes. If we've detected a violation of our policies you'll receive an email and a notification to your account with further information and instructions. And you can read all about the causes of invalid activity at our Ad Traffic Quality Resource Center, which is now available in most languages supported by AdSense, such as German, French, Polish and Arabic.
Whether you're looking for a refresher or just creating your first ad unit, you can review the do's and don'ts of ad traffic in our expanded AdSense Academy.
In order to help publishers avoid common pitfalls, we're kicking off a video series that explains why some of our policies exist and how you can make sure you're working with them. Our first looks specifically at invalid traffic.
We want to work with our publisher partners to keep the AdSense network strong -- keeping good publishers' accounts in good standing, while also protecting advertisers and users from fraudulent activity. This is why we're making changes, like the ones discussed today, to provide more help when things go wrong. We'll be making even more changes as the year goes on so look for continued updates on this blog.
We want to hear from you. Let's continue the conversation -- submit your questions to us about the topics discussed in this post via Google Moderator. We'll be holding a Google Hangout in January with members of our Product Quality Operations team for the first time to address your questions. Please note that for privacy reasons, we won't be able to respond to account-specific questions.


text:
A healthcare worker prepares a dose of the Pfizer-BioNTech COVID-19 vaccine at a UHN COVID-19 vaccine clinic in Toronto on Thursday, January 7, 2021. THE CANADIAN PRESS/Nathan Denette
Pfizer submits trial data on vaccine use in children aged 5 to 11 to Health Canada
Pfizer submitted the preliminary data for children aged five to 11 Friday afternoon
Pfizer has submitted preliminary research to Health Canada on the effectiveness of its COVID-19 vaccine in children aged five to 11.
The drugmaker confirmed Saturday it provided the initial trial data to the federal department for review as it prepares to make a formal submission seeking authorization to use the product in children.
Pfizer said its formal submission could come later this month.
Health Canada said in an email that Pfizer submitted the preliminary data for children aged five to 11 Friday afternoon, which was earlier than expected. The department said it expects the formal filing of the company's submission in mid-October.
Pfizer Canada spokeswoman Christina Antoniou said the submission will be a request for full authorization.
She said the new drug submission process for COVID-19 vaccines offers the same flexibility as the interim order authorization pathway did, including allowing the company to submit a rolling submission.
"In other words, [it's] not an emergency use authorization but a full approval under which we would continue to submit new data as it becomes available," Antoniou said in an email.
Pfizer's vaccine was initially given the green light for use in Canada last December under an interim order authorization and received full approval last month.
The two-shot vaccine, developed in partnership with German pharmaceutical company BioNTech, is currently available for those aged 12 and older.
The company is testing a lower dose of the shots in children.
Pfizer and BioNTech said last week that researchers found the vaccine antibody responses in children were just as strong as those found in teenagers and young adults getting regular-strength doses.
The companies submitted the research to the U.S. Food and Drug Administration last week and plan to request emergency use authorization of their vaccine in children ages five to 11 "in the coming weeks." The companies also plan to submit data to the European Medicines Agency and other regulators.
In addition, research involving even younger children is also taking place.
Pediatric studies evaluating the safety and efficacy of Pfizer's COVID-19 vaccine in children aged six months to age five is ongoing, with initial results expected before the end of the year, Antoniou said.
Meanwhile, Health Canada approved the use of Moderna's COVID-19 vaccine in kids as young as 12 in late August.
The American drugmaker is also in the midst of vaccine trials for children younger than 12, with results expected sometime this fall.
— With files from The Associated Press.
– Brett Bundale, The Canadian Press
Military to 'be in position' Monday to decide where to deploy nurses in Alberta
Digital literacy program in Langford, Sooke pairs teens with 55+


Messages sent to conference attendees and speakers are posted in reverse chronological order, so that you may see messages that were sent out before you registered.
As a service to attendees, ICSA runs a bookstore at its annual conferences in the USA. In addition to ICSA books, we also consider selling on consignment books by speakers, poster presenters, and Phoenix Project contributors. If a book is accepted for the bookstore, we ask the contributor to bring a supply of books (usually 10, though popular books may sell 20 or more). We usually sell books at prices that are easy to give change for, e.g., $10, $15, $20, etc. We mark the number, the price, and the percent that ICSA gives to the author (usually 60%, though this can vary). We pay authors only for books sold, and authors are expected to take back any unsold books. Authors may also – or instead – bring flyers for their book, which can be left on a table used to display flyers from attendees.
Variety of Attendees: An ICSA annual conference typically has over 100 speakers expressing many different points of view. Attendees are former group members, researchers, helping professionals, and families concerned about a loved one. We also sometimes have current members of groups present. The conference is open to the public.
Attend the preconference former member workshop. It will help prepare you for the conference.
Though you may sometimes hear views with which you disagree or which you may even find offensive, we hope that you will listen and, if you feel comfortable doing so, express your disagreement during question and answer periods. You have as much right as anybody else to state your opinions. But keep in mind that others have a right to disagree with you.
If a session makes you uncomfortable, feel free to walk out.
If you want to talk about feelings that arise during the conference, consider talking to a member of our Assistance Team (identifiable by their nametags). These are counselors with experience working with former group members.
Each day of the conference will have two open discussion sessions, one for people born or raised in cultic groups and one for people who joined a group as an adult ("first generation" former members). Attend these sessions to discuss topics that may not be on the agenda or that are of special concern to you.
Bus Tour. If you want to take part in the Sunday bus tour of NRM places, you may do so with your registration. If you are already registered and only want the bus tour, select tour only on the registration page URL above.
Visa issues. Let us know if you need a letter.
Check bios and let us know if changes are neededhttp://www.icsahome.com/events/conferenceannual/speakers Send jpg if you want to add/change your photo.
We will re-send this reminder periodically.
Check bios and let us know if changes are needed – Send jpg if you want to add/change your photo.
Pat Ryan, Joe Kelly, and Joe Szimhart (see people profiles) are organizing a special guided bus tour of Philadelphia new religious movement sites after the ICSA conference. They will also serve as tour guides. The tour will take place from 1 pm to 6 pm on Sunday, July 8, 2018.
Tentatively, the tour may include the Father Divine historical landmark, the Swedenborg Cathedral, the Kelpius Cave, The I AM Temple, a café frequented by followers of Madame Blavatsky, and other sites. Pat and the two Joes will provide an interesting commentary on the various sites to be visited.
The fee for the tour is $35.
Space is limited and there is an end-date on purchasing tour tickets, so register soon.
The Phoenix Project invites your participation in the next Phoenix Project of Ex-Cult member art, literary, and other creative works. If you are a former cult member or born and raised in a high demand group environment, please submit your creative works, related to cult affiliation, for this year's exhibit at the annual ICSA conference in Philadelphia, PA, July 5-7.
The Phoenix Project consists of both an exhibit room and a performance time. This means that works considered for inclusion are those in a number of genres: visual artwork in two and three dimensions, musical compositions, video, dance, and literary works such as drama, short story, and poetry.
It is requested that works submitted pertain to the cult group experience, such as joining the cult, time in the group, exiting, and aftereffects.
Works may be kept anonymous, if desired.
For more information, please contact Phoenix Project Director Diana Pletts at exmemberartwork@yahoo.com.
The International Cultic Studies Association (ICSA) is conducting its 2018 Annual International Conference with Info-Secte/Info-Cult of Montreal in Philadelphia, Pennsylvania, July 5-7, 2018 (preconference workshops on Wednesday July 4th). The conference theme is the global challenge of young people born, raised or recruited into extremist groups, abusive religious organizations, or coercive/exploitative relationships. The conference committee is especially interested in considering poster sessions from students.
Please submit your research, including research in progress, and be part of a growing and exciting international community of researchers in the field of cultic studies, religious studies, and sectarianism, undue influence, and new religious movements.
Boundaries between the individual and society in group and other contexts.
Your proposal should consist of an abstract of 300 words or less. We also welcome group research project submissions. We also need a short biographical sketch. If you already have one on our people profile page, let us know if it is okay or needs changing. If we do not have a bio, please send one. Send your proposal to mail@icsamail.com.
In a poster session, one explains one's paper on a poster placed on an easel or a table or a wall. Typically, the poster presenters will pin or tape pages (e.g., an abstract with a large font) from their paper. You should also have either copies of your paper to hand out or a business card attendees can use to e-mail a request that you send them a copy of your paper. Attendees pass through the poster area, examining the posters and speaking with authors individually. In a poster presentation, one does not formally present to a group; however, one has an opportunity for quality interactions and followup with those who are most interested in your work. ICSA will contact poster presenters about logistical details as the conference draws near.
ICSA is NOT accepting proposals for speaking, only for posters. The deadline for speaking proposals is long past.
Pat Ryan, Joe Kelly, and Joe Szimhart are organizing a special guided bus tour of Philadelphia cult/NRM sites for the Sunday after the ICSA conference. The tour will take place from 1 pm to 6 pm on Sunday, July 8, 2018. If you are interested in attending, please hold the date and adjust your travel plans.
Since we are still working out details, we do not yet know the precise price of the tour. However, we expect it to be in about $40 for the afternoon.


The new Minnesota Pollution Control Agency (MPCA) Wastewater Pretreatment Rules (Minnesota Rules 7049) recently became effective. Prior to promulgation of these Rules, Minnesota industries that discharged to their local Publicly Owned Treatment Works (POTW) and where subject to Federal pretreatment requirements did not have easy options to demonstrate compliance, especially if they were located outside of a major metropolitan area.
One of the key elements of the new MPCA Rule is the definition of "Significant Industrial Users". These industrial dischargers will have increased reporting and monitoring requirements. POTWs must identify all their Significant Industrial Users and report on them annually to MPCA.
For more information on this new Rule, go to Regulatory Briefing - New Minnesota Pretreatment Rule. Caltha publishes Regulatory Briefings to highlight new or proposed Federal and State regulations; Click here to register to receive these Briefings by email.
Caltha LLP assists industrial dischargers to meet permitting, monitoring and reporting requirements.


text:
Q: Are the following examples of global variables? I know that a global variable is a variable with global scope. I know that global scope means it can be seen by all. Does that mean, in node.js, that n here is a global variable?
let n = 1

function f() {}
...

I've also read that a global variable can be defined as a property of the global object e.g. global.clearInterval. global.clearInterval can be seen anywhere so has global scope. Is it right to call a property of the global object a global variable?

A:
Does that mean, in node.js, that n here is a global variable?

It depends on how you run it. By default, no, because Node.js treats your code as a module, not a script. Top-level declarations in modules aren't globals, they're scoped to the module.
If you were running that code as a script, then n (and f) would be global variables (although, amusingly, they're different kinds of global variables; more below). With Node.js, you can run code at global scope by feeding the code directly into Node.js instead of giving it a file to execute. So if you have:
file.js:
function f() { }
console.log(global.f === f);

And you do this:

node file.js

you'll see false, because f isn't a global. But if you do:

node -e "function f() { } console.log(global.f === f);"

you'll see true, because code you pass in the -e ("eval") option is executed at global scope. (You can also do it from a file by redirecting the file into node instead of having node read the file directly: node < file.js.)
Note that n won't be a property of global either way, though, because it's a different kind of global.

I've also read that a global variable can be defined as a property of the global object e.g. global.clearInterval. global.clearInterval can be seen anywhere so has global scope. Is it right to call a property of the global object a global variable?

Yes, mostly. That is: properties of the global object are global variables, but JavaScript actually has two kinds of global variables: Ones that are properties of the global object, and ones that aren't. At global scope, var and function declarations create global variables that are properties of the global object, but let, const, and class declarations create globals that aren't properties of the global object.
The global environment that uses the global object is the "outer" global environment. The one where identifiers created by using let, const, and class declarations at global scope is the "inner" global environment. That means that let/const/class globals shadow globals on the global object, just like local variables in a function shadow variables declared outside the function.

Side note: Beware that global is a Node.js-specific global not present in most other JavaScript environments. ES2020 adds a new predefined global, globalThis, which is the same value that this has at global scope (which, traditionally, refers to the global object), which takes the place of Node.js's global.

redpajama_set_name: RedPajamaStackExchange


text:
Miguel Alonso (born July 18, 1952) is a Cuban former wrestler who competed in the 1972 Summer Olympics and in the 1976 Summer Olympics.

References

External links

1952 births
Living people
Olympic wrestlers of Cuba
Wrestlers at the 1972 Summer Olympics
Wrestlers at the 1976 Summer Olympics
Cuban male sport wrestlers
Pan American Games medalists in wrestling
Pan American Games silver medalists for Cuba
Pan American Games bronze medalists for Cuba
Wrestlers at the 1971 Pan American Games
Medalists at the 1971 Pan American Games
20th-century Cuban people
21st-century Cuban people

redpajama_set_name: RedPajamaWikipedia


text:
Montreat Minute 09/18/20
Last Call to be Counted!
The Constitutionally mandated 2020 Census will remain available for being counted until September 30. Currently, more than 40% of all North Carolina households have not yet filled out the 2020 Census, representing more than 4 million North Carolinians not currently included in the Census. And here in Buncombe County, our specific census tract is in the bottom five of the county for response rate.
Why is it important? There are many reasons, but two primary ones are:
The census directly affects the allocation of $43.8 billion annually in federal funds to North Carolina for critical public services such as hospitals, schools, road repairs and emergency response services for the next 10 years in North Carolina. We will lose Federal funding if our population is not accurately counted.
A proper census count ensures that communities are appropriately represented in the statehouse and in Congress.
For more information on why the Census is important, CLICK HERE.
If you have not yet been counted, either by responding on your own or being counted by a Census field worker, there is still time. You can be counted online (my2020census.gov), by phone (844-330-2020), or by paper questionnaire until September 30. Completing your Census form at home reduces the need for a Census worker visit. The Census workers going door-to-door will have COVID protection (ie masks and gloves), and they will maintain social distance.
Please be counted today!
Thank You Public Works!
Public Works staff has been busy on the Greybeard Trail guardrail this week, and it is completed. The work was necessitated by damage done by Tropical Storm Alberto in May 2018. Now that the creek work is completed, PW staff were able to replace the guardrail. Further work will be done to control water in the area, but the guardrail is fully functional. Thank you Barry, Daniel, Jarod and Mike.
The Montreat Tree Board will meet on Tuesday, September 22, 2020, at 9:30 a.m. virtually via Zoom. CLICK HERE for information on joining the virtual meeting.
The Planning & Zoning Commission will meet on Thursday, September 24, 2020, at 10:30 a.m. virtually via Zoom in its continuing effort to review Town Zoning Ordinances. Their work is nearly complete, at which time they will pass on their findings and recommendations to the Town Council for action. CLICK HERE for information on joining the virtual meeting.
The Board of Adjustment will also meet on Thursday, September 24, at 5:00 p.m. virtually via Zoom. CLICK HERE for information on joining the virtual meeting.
The Town Hall remains closed to the public. Staff are working in the building and may be reached by calling 828-669-8002. Green and blue Town trash bags are available by calling before picking up at the Town Hall. Water bills may be paid by dropping payment in the drive-by payment box adjacent to the new Town Hall driveway by the pocket park.
Do you have Town-related questions you would like answered? If so, please send them to Angela Murphy at info@townofmontreat.org and we will get back to you as soon as possible.
Stay well and have a good weekend.


Various tissue types combine to make up__________?
Functional unit of DNA Is____________?
With different chemical arrangements and formation Of complex molecules, the life emerges on the level of the ?
Human blood is an example of__________?
According to modern system of taxonomy, living organisms have been classified into?
The word "BIOLOGY" has been derived from_________ word?
Sheena is a local language of __________ ?
In summer season polo tournaments are held in ________ ?
Polo game originated from __________ ?
The capital of Gilgit Baltistan is __________ ?
Which Pakistani area is sandwiched between China and Indian-held Kashmir?
Baltistan is called _________ ?
Which valley is known as "Roof of the world"?
Who is the first Chief Minister of Gilgit Balitistan?
Who was the first Women Governor of Gilgit Balitistan?
Who was the first Governor of Gilgit Balitistan?
Second Highest mountain of the world K-2 is located in __________?


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Tag: Carol Mann
October 12, 2015 Conflict resolution, War crimes
Carol Mann: Premeditated slaughter in Ankara
On October 5, President Erdogan held an election rally, not on home ground in Turkey, but Strasbourg, France. After prayers led by an imam, the president of what theoretically is the only secular state in the Middle East, launched into belligerent diatribe designed to rouse the 12 000 Turks who had come in from neighbouring countries. Complete with sound and light effects, the crowd, cordoned off with males on one side and bescarfed females on the other, egged him on to cries of "Allah u Akbar". Had the enemy he was thundering against been ISIS, Turkish presence as a member of NATO in a fellow NATO country could have had some form of legitimacy. But here the target of his wrath was no less that one third of his own population, namely the Kurds and members of the HDP opposition party, in fact those he described in his speech as being All those who wish to separate from us'. Then he uttered an ominous threat: we will make sure they live regret it. Continue reading "Carol Mann: Premeditated slaughter in Ankara" →


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We turn an empty exhibition hall into an inspiring meeting place in no time. Our well-selected teams work fast and efficiently. Meet our staff. We are happy to give you more information and to explain to you the way we work.
Alter expo is a fun, challenging and inspiring place to work. We like to share our positive spirit, especially with those in less fortunate situations. That is why we have set up a heartwarming tradition, one that really suits the values of alter expo. Each year we donate to charity the budget devoted to end-of-the-year gifts and we also sponsor some special charities. Discover here the projects for which our heart beats faster.


Here is a round-up of all the parks we have visited and featured over the years on Metro Detroit Mommy. Of course, there are so many more that we haven't visited, so drop me a line if there is one I simply must feature in an upcoming article.
Sports-loving kids? Take them to Borden Park!
10 Metro Detroit Parks We LOVE!


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Two African American Woman Appointed to Dean Positions at Universities
Filed in Breaking News on August 31, 2020
Evelyn L. Ashley has been named dean of students at the University of Massachusetts Amherst. She will assume her new responsibilities on September 14. Most recently, she served as associate dean of students and director of student support, advocacy, and accountability at Southern Methodist University in Dallas.
Dr. Ashley earned a bachelor's degree in exercise sports science from Hamline University in St. Paul, Minnesota. She holds a master's degree in adult learning and development from Cleveland State University and a Ph.D. in higher education administration from Bowling Green State University in Ohio.
Henrietta Williams Pichon, an associate professor of educational leadership and administration, was appointed interim dean of the College of Education at New Mexico State University. She has been serving as associate dean.
Dr. Pichon holds a bachelor's degree in English and a master's degree in secondary English education from Louisiana Tech. She earned a Ph.D. in higher education administration at the University of New Orleans.
Related: New Mexico State University • University of Massachusetts


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Story Of The Kite Maker: Ravindra Pal Singh, Chasing The Flying Dream
Kite making is not just a business, it's a centuries-old art.
On Makar Sankranti, the festival of kites, we see the sky dotted with different coloured 'Patangs'. On this day, scores of kites fill the sky, all trying to compete against each other. These kites never fail to awe us as we see them soar across the skies.
Kite making is an art that has been passed down for generations, and like many other traditional arts it has also become scarce and is dwindling. We spoke to Ravindra Pal Singh, known as Pal uncle, a famous kite maker from Navi Mumbai. He learnt how to make the kites over 40 years ago when he was a kid. "I started because of poverty, my father wasn't rich, and we needed the money. One day as I was playing with my friends, I saw a colourful kite and wanted to buy it. My mother said that we couldn't afford it and that's when I decided to make my own kites. Initially, it took me 9-11 hours to make a single kite". The journey might have been slow for Pal uncle, but it has been a successful one. He learnt how to make kites and moved to Mumbai with big dreams, which he achieved over decades.
The tradition of kite making isn't new in India, many believe that kites were first brought to India by the Chinese travellers, Fa Hien and Hiuen Tsang, but since then kite flying has become a part of Indian traditions. Though looking at the kites is delightful it takes as much effort, skill and time to make them.
When we asked him about the difference, he has seen in the industry over years he said, "When I initially started, I had seen entire families working together to create the kites, which takes incredible skill and talent by each member. But over years I've seen the family businesses dwindle, the kids of course have gone on to pursue their own dreams instead of learning the family art."
"I also have two children, a son and a daughter, both are on good posts and doing well in life". Over decades his kite-making business has grown and he has made profits in crores. Along with the kite making business, he has also grown a small real estate agency of his own in Vashi, sector 16. "Now I don't make kites because I need the money, I make kites because it's my passion. I do it because it's an art that helped me make my life and saved my family."
When asked about what the future holds for the industry he said, "COVID and lockdown has impacted the industry severely and has forced many small makers and outlets to shut down or find other occupations." He also said that, "the traditional kite-making has been challenged by the factories for a long time now, and post-COVID it seems to have borne the hit better than the smaller businesses."
There is a certain sadness in Pal uncle's eyes as he says, "The only way to save the traditional kite-making industry is if new hands are trained in the trade, and if it's also integrated with the tools to reach broader audience that modern technology offers, or else sadly the industry will die a natural death."
We truly hope the art of kite making survives and is celebrated as much as the festival of Makar Sankranti itself.
Read more: Lohri 2021: Do it right!
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Dhwani Patel
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South Western Railway Turns Two Old Coaches Into Classrooms
The South Western Railway in Mysuru has turned two old coaches into classrooms. The Railway Colony Primary School uses them as classrooms to teach impoverished children.


Spectacular views into Porpoise Bay Inlet from this renovated and updated 3 bedroom home. The open living concept and massive deck off the gourmet custom kitchen makes this home perfect for entertaining. Lots of extras including new vinyl windows, new gas fireplace and granite kitchen counters. Downstairs boasts a huge rec room that is currently used as a Yoga space. Low maintenance gardens leave you lots of time to enjoy the many recreational opportunities that Sandy Hook has to offer. Lots of hiking trails within walking distance of your front door. Explore the inlet beaches by kayak or boat or head down to the local beach for an evening swim. Call today for an information package!


The IRS uses property seizure as a last resort when attempting to resolve tax debt. While the notion of having a car, house or bank account seized can be terrifying for many individuals and families, the IRS employs various rules, regulations and procedures to ensure that tax-payers are protected and are given every opportunity possible to resolve the tax debt either through litigation or offers in compromise. However, even with strict controls in place, the seizing of assets can run afoul of common sense.
Here are 5 times when IRS property seizure seemed to contradict common sense.
Hair care products: In 2015, the IRS seized a full supply of Aveda hair care products, a dermabrasion machine and more equipment from an Alabama hair salon.
Parking spaces: A pair of parking spaces in the city of Boston were seized in 2013. They were sold at auction for $280,000 each.
Darryl Strawberry's New York Mets salary: The IRS had seized the rights to Darryl Strawberry's deferred Mets salary from the team option portion of his 1990 contract. They auctioned off the salary rights in 2015.
A rapper's property: Popular rapper Young Buck filed bankruptcy in 2012 and the IRS seized numerous assets. The rapper reportedly bought many his own seized items at auction.
Native American land: The IRS claimed the Crow Creek Sioux failed to pay more than $3 million in taxes over the course of several years from 2003. The tribe argued that they were incorrectly informed that as a federally recognized tribe they were not required to pay federal taxes. More than 7,000 acres of land were sold to a private bidder in 2009.
Asset seizure is a powerful debt collection tool and the IRS is given broad authority in these matters. In recent years, however, many controls were put in place – including an annual audit of the IRS itself – to ensure they were following the strict procedures. While these stories of property seizure can seem strange – or even humorous – losing a home, car, bank account or collection of assets can be an emotionally painful event. If you are facing an IRS audit or fear the agency will attempt to seize your assets to recover debt, you need a skilled tax attorney on your side.


Walking down the Wisteria Flower Tunnel at Kawachi Fuji Garden (Kitakyushu, Fukuoka, Japan) under its beautiful cascading flowers will be a breathtaking stroll. Purple, violet, pink, and white wisteria flowers cascade above you forming a tunnel during its full bloom season in late April to May. Be sure to visit during these months because at any other time of the year, the garden will look lifeless without any of the wisteria flowers. The flowers bloom more beautifully this time of the year but bloom more on some years than others.The park gets crowded with people though so if you're looking to take the perfect picture of Wisteria Flower Tunnel without a crowd of people in it, it is best to go early when the park opens.
Japan Deluxe Tours has many tours throughout Japan including the Southern Japan Tour which explores the Kyushu area. Join any of our tours to explore the highlights of Japan and extend your stay to visit the beautiful Wisteria Flower Tunnel.


Michigan Farm Bureau's Health Services program will host "Medicare Made Easy" classes over the coming months.
There will be three classes held in December.
The free classes are open to the public and will be held at locations across the state.
Anyone who will be eligible for Medicare soon is encouraged to attend and learn from Medicare experts. No products will be sold — this is a strictly educational offering.