text:
En  la mitología griega, Yamo (Ἴαμος / Íamos, de ἴον / íon: «violeta») era hijo de Apolo y Evadne, hija de Poseidón.

Avergonzada por su embarazo, Evadne expuso al niño a los elementos. Yamo sobrevivió, ya que dos serpientes lo alimentaron con miel. Entonces fue encontrado vivo yaciendo entre violetas, y fue llamado Yamo por Evadne. Cuando creció, se sumergió en las aguas del Alfeo e invocó a Poseidón, su abuelo, y a Apolo, su padre, pidiéndoles que le revelaran su destino. Apolo le mandó ir a Olimpia. Concedido por Apolo el don de la profecía, fundó allí una familia de sacerdotes: los Yámidas (Iamidae).

Notas y referencias

 PÍNDARO: Olímpicas, VI, 47-73.

 PAUSANIAS: Descripción de Grecia, VI, 2, 5.

Enlaces externos

 FLOWER, Michael A.: The Iamidae: A Mantic Family and Its Public Image (Los Yámidas: una familia de adivinos y su imagen pública), en Practitioners of the Divine: Greek Priests and Religious Figures from Homer to Heliodorus (Practicantes de lo divino; los sacerdotes y los religiosos de la Antigua Grecia desde Homero hasta Heliodoro), 2008.
 Texto, en inglés, en el sitio del Centro de Estudios Helénicos (CHS o Center for Hellenic Studies), institución de Washington afiliada a la Universidad de Harvard y dirigida por Gregory Nagy.
 Para las citas: Dignas, Beate, and Kai Trampedach, eds. 2008. Practitioners of the Divine: Greek Priests and Religious Figures from Homer to Heliodorus. Hellenic Studies Series 30. Washington, DC: Center for Hellenic Studies.

Semidioses descendientes de Apolo
Sacerdotes de la Antigua Grecia
Videntes de la mitología griega


text:
Broadcasting House
I've spent a couple of months in London making a programme for the BBC Radio 4 series Face The Facts. I'll be blogging about the programme soon (if and when it's broadcast!).
I've thoroughly enjoyed working in Broadcasting House, the BBC's multimedia broadcasting centre right in the heart of London. Last year the new part of the building opened and the sections of the BBC that were in Television Centre, Bush House and elsewhere have now moved in, including the BBC News Channel and the World Service.
The BBC has just started doing tours around Broadcasting House which I can recommend as something to do when you're in London as you can see the news operation at work including the BBC News Channel studio.
I've been making the most of the opportunity of being down in London and watching a few BBC Radio 4 programmes being recorded at the Radio Theatre which is part of Broadcasting House. It's easy to apply for the free tickets and an enjoyable way to spend an evening with a friend in the city. You can apply for tickets on the BBC Tickets website.
And while I'm on the subject of the BBC, there's a new website looking back at the significant events in the BBC's history. There's some wonderful video and audio archive on the website and it's well worth exploring: BBC Where Next?
Posted by Mark Ansell at Friday, April 26, 2013 No comments:
Labels: BBC, London

redpajama_set_name: RedPajamaCommonCrawl


text:
HomeDiseases and ConditionsHaemophilus influenzae type B (Hib)
Haemophilus Influenzae Type B
DiseaseControl@flhealth.gov
4052 Bald Cypress Way
Hib disease
What is Hib disease?
Haemophilus influenzae (huh-mof-ill-us in-floo-en-za) type b, or Hib for short, is an infection caused by the bacterium Haemophilus influenzae. The most common type of invasive Hib disease is meningitis, an infection of the membranes that cover the spinal cord and brain. It usually affects young children under the age of five. There are six different types of this bacteria (a, b, c, d, e and f). While all types of the bacteria may cause infection, H. influenzae type b can cause severe disease in children.
Who gets Hib disease?
Hib at one time was the leading cause of bacterial meningitis or pneumonia among infants and children younger than five years of age. In 1988 the Hib vaccine was made available. Since the Hib vaccine is now routinely given to infants and children, the number of Hib disease cases in the United States has declined by more than 95%. Currently, Hib disease occurs mostly in infants who are not fully immunized and is most common among those between six—18 months of age. While Hib is not common among adults or children older than five years, people with certain long-term health conditions or weak immune systems are at higher risk for Hib disease.
How do people get Hib disease?
Hib bacteria are spread from person to person. Some people carry Hib bacteria in their nose and do not become infected. They can, however, pass the bacteria to others who may become sick. People can also become sick if they are exposed to the mucus or saliva (spit) from an infected person who is not getting treatment.
What are the symptoms of Hib disease?
Symptoms of Hib depend on what part of the body is affected by the bacteria. Most often, Hib bacteria will cause meningitis.
Symptoms of meningitis include:
• Fever
• Decreased mental status
• Stiff neck
Other forms of Hib infection include pneumonia, epiglottitis (an infection and swelling of the throat that can block the airway) and bone or joint infection.
How is Hib disease diagnosed?
If a health care provider suspects Hib, samples of the patient's blood or spinal fluid will be examined.
What is the treatment for Hib disease?
Your health care provider can prescribe antibiotics to treat Hib. (NOTE: It is very important to finish your antibiotics even if you begin to feel better, unless otherwise directed by your health care provider.) People with Hib are no longer able to spread it to others after taking antibiotics for 24-48 hours.
How can I reduce my chances of becoming infected with Haemophilus influenzae type b (Hib)?
• Protect your children by having them immunized with the Hib vaccine. The vaccine is a series of four shots and is given at 2, 4, 6 and 12-15 months of age. It is recommended for all children younger than 5 years old in the US, and it is usually given to infants starting at 2 months old. The Hib vaccine can be combined with other vaccines. Some brands of vaccine contain Hib along with other vaccines in a single shot. Hib vaccine can safely be combined with other vaccines to make these combination vaccines.
• Cover coughs and sneezes with a tissue. Throw away used tissues immediately.
• Wash hands frequently.
If you have any questions, please contact your health care provider.
More information from the Centers for Disease Control and Prevention (CDC).


text:
using System;
using System.Collections.Generic;
using System.Linq;

namespace SpentBook.Domain.Services
{
    public class TransactionService
    {
        private IUnitOfWork uow;
        public TransactionService(IUnitOfWork uow)
        {
            this.uow = uow;
        }

        public List<Transaction> GetTransactionsFiltrated(TransactionFilter filter)
        {
            var query = this.uow.Transactions.AsQueryable();

            //var a = new ResumeController();
            //var transactions = a.GetSpents();
            //query = transactions.AsQueryable();

            var onlyInputs = filter.TransactionType == TransactionType.Input;
            var onlyOutputs = filter.TransactionType == TransactionType.Output;

            if (onlyInputs)
                query = query.Where(t => t.Value > 0);

            if (onlyOutputs)
                query = query.Where(t => t.Value < 0);

            if (filter.Categories != null && filter.Categories.Count > 0)
                query = query.Where(t => filter.Categories.Contains(t.Category));

            if (filter.SubCategories != null && filter.SubCategories.Count > 0)
                query = query.Where(t => filter.SubCategories.Contains(t.SubCategory));

            if (filter.Names != null && filter.Names.Count > 0)
                query = from t in query
                        from name in filter.Names
                        where t.Name.ToLower().Contains(name.ToLower())
                        select t;

            if (filter.DateStart != null)
                query = query.Where(t => t.Date >= filter.DateStart);

            if (filter.DateEnd != null)
                query = query.Where(t => t.Date <= filter.DateEnd);

            if (filter.ValueStart != null)
                query = query.Where(t => t.Value >= filter.ValueStart);

            if (filter.ValueEnd != null)
                query = query.Where(t => t.Value <= filter.ValueEnd);

            if (filter.IdUser != null)
                query = query.Where(t => t.IdUser == filter.IdUser);

            var expressionOrderBy = filter.GetOrderByExpression(filter.OrderBy, out string orderByName);

            if (filter.OrderByClassification == OrderClassification.Asc)
                query = query.OrderBy(expressionOrderBy);
            else
                query = query.OrderByDescending(expressionOrderBy);

            return query.ToList();
        }

        public TransactionGroup GetTransactionGroupRoot(List<Transaction> transactions, params TransactionGroupDefinition[] groupDefinitions)
        {
            Func<List<Transaction>, TransactionGroup, int, List<TransactionGroup>> methodGroup = null;
            methodGroup = (_transactions, transactionGroupParent, groupByIndex) =>
            {
                var groupByDefinition = default(TransactionGroupDefinition);
                var transactionGroups = new List<TransactionGroup>();

                if (groupDefinitions.Length > groupByIndex)
                    groupByDefinition = groupDefinitions[groupByIndex];

                if (groupByDefinition != null)
                {
                    var _transactionsQueryable = _transactions.AsQueryable();

                    if (groupByDefinition.OrderByClassification != null)
                    {
                        if (groupByDefinition.OrderByClassification == OrderClassification.Asc)
                            _transactionsQueryable = _transactionsQueryable.OrderBy(groupByDefinition.OrderByExpression);
                        else
                            _transactionsQueryable = _transactionsQueryable.OrderByDescending(groupByDefinition.OrderByExpression);
                    }

                    var group = _transactionsQueryable
                        .GroupBy(groupByDefinition.GroupByExpression)
                        .ToList();

                    transactionGroupParent.GroupByDefinition = groupByDefinition;

                    var nextGroupByIndex = groupByIndex + 1;
                    var transactionGroupsNews = group.Select(
                        (g, gIndex) =>
                        {
                            var list = g.ToList();
                            var name = this.GetTransactionGroupNameUsingValue(groupByDefinition.GroupBy, list);
                            var key = g.Key;
                            var transactionGroup = ConfigureTransactionGroup(new TransactionGroup(), key, name, list, null, transactionGroupParent, nextGroupByIndex);
                            transactionGroup.SubGroups = methodGroup(list, transactionGroup, nextGroupByIndex);
                            return transactionGroup;
                        }
                    );

                    if (groupByDefinition.OrderByGroupClassification != null)
                    {
                        if (groupByDefinition.OrderByGroupClassification == OrderClassification.Asc)
                            transactionGroupsNews = transactionGroupsNews.AsQueryable().OrderBy(groupByDefinition.OrderByGroupExpression);
                        else
                            transactionGroupsNews = transactionGroupsNews.AsQueryable().OrderByDescending(groupByDefinition.OrderByGroupExpression);
                    }

                    var transactionGroupsNewsList = transactionGroupsNews.ToList();
                    transactionGroups.AddRange(transactionGroupsNewsList);
                }

                return transactionGroups;
            };

            var transactionGroupRoot = new TransactionGroup();
            ConfigureTransactionGroup(transactionGroupRoot, null, "Todos", transactions, null, null, 0);
            transactionGroupRoot.SubGroups = methodGroup(transactions, transactionGroupRoot, 0);
            return transactionGroupRoot;
        }

        public List<ChartDataCategorized> GetChartDataCategorized(TransactionGroup transactionGroupRoot, bool tryCategorize = true)
        {
            var listReturn = new List<ChartDataCategorized>();
            Action<TransactionGroup, ChartDataCategorized> methodGroup = null;
            int id = 0;
            methodGroup = (current, parentTransversal) =>
            {
                if (current.SubGroups.Count == 0)
                    return;

                //if (grandchildrenGroups != null)
                //    if (current.GroupByDefinition.OrderByClassification == TransactionOrderClassification.Asc)
                //        grandchildrenGroups.OrderBy(f => f.Key);

                //if (tryCategorize && grandchildrenGroups.Count > 0)
                // categoriza apenas o root se for solicitado
                if (tryCategorize && current.Parent == null)
                {
                    var children = current.SubGroups;
                    var grandchildrenGroups = children.SelectMany(f => f.SubGroups).GroupBy(f => f.Key).ToList();

                    foreach (var grandchildrenGroup in grandchildrenGroups)
                    {
                        var list = grandchildrenGroup.ToList();

                        var inverted = new ChartDataCategorized()
                        {
                            Id = ++id,
                            IdParent = (parentTransversal == null ? null : (int?)parentTransversal.Id),
                            ParentPath = current.GetPath(),
                            ItemGroupName = grandchildrenGroup.Key.ToString(),
                            Items = new ChartDataCategorized.Item[children.Count]
                        };

                        listReturn.Add(inverted);

                        foreach (var grandchild in list)
                        {
                            var indexOfParent = current.SubGroups.IndexOf(grandchild.Parent);
                            inverted.Add(grandchild.GetPath(), grandchild.Parent.Key.ToString(), indexOfParent, grandchild);
                            methodGroup(grandchild, inverted);
                        }
                    }
                }
                else
                {
                    var name = current.Key != null ? current.Key.ToString() : (current.GroupByDefinition != null ? current.GroupByDefinition.GroupByName : "");
                    if (current.Parent == null && name == null)
                        name = current.SubGroups.First().GroupByDefinition.GroupByName ?? "Todos";

                    var inverted = new ChartDataCategorized()
                    {
                        Id = ++id,
                        IdParent = (parentTransversal == null ? null : (int?)parentTransversal.Id),
                        ParentPath = current.GetPath(),
                        ItemGroupName = name,
                        Items = new ChartDataCategorized.Item[current.SubGroups.Count]
                    };

                    listReturn.Add(inverted);

                    var index = 0;
                    foreach (var childGroup in current.SubGroups)
                    {
                        inverted.Add(childGroup.GetPath(), childGroup.Key.ToString(), index++, childGroup);
                        methodGroup(childGroup, inverted);
                    }
                }

                //foreach(var child in children)
                //    methodGroup(child, 0);
            };

            methodGroup(transactionGroupRoot, null);

            return listReturn;
        }

        private TransactionGroup ConfigureTransactionGroup(TransactionGroup transactionGroup, object key, string name, List<Transaction> transactions, List<TransactionGroup> subGroups, TransactionGroup parent, int level)
        {
            transactionGroup.Key = key;
            //transactionGroup.GroupByDefinition = groupByDefinition;
            transactionGroup.Name = name;
            transactionGroup.Parent = parent;
            transactionGroup.Transactions = transactions;
            transactionGroup.SubGroups = subGroups;
            transactionGroup.Level = level;

            if (transactionGroup.Total == 0)
                transactionGroup.Total = transactionGroup.Transactions.Sum(f => f.Value);

            if (transactionGroup.Count == 0)
                transactionGroup.Count = transactionGroup.Transactions.Count;

            //transactionGroup.TotalAsPositive = Math.Abs(transactionGroup.Total);
            if (parent == null)
            {
                transactionGroup.TotalPercentage.Add(100m);
                transactionGroup.CountPercentage.Add(100m);
            }

            while (parent != null)
            {
                transactionGroup.TotalPercentage.Add((transactionGroup.Total * 100m) / parent.Total);
                transactionGroup.CountPercentage.Add((transactionGroup.Count * 100m) / parent.Count);

                parent = parent.Parent;
            }

            return transactionGroup;
        }

        private string GetTransactionGroupNameUsingValue(TransactionGroupBy? group, List<Transaction> transactions)
        {
            if (group != null)
            {
                var transaction = transactions.FirstOrDefault();
                switch (group)
                {
                    case TransactionGroupBy.Category:
                        return transaction.Category;
                    case TransactionGroupBy.SubCategory:
                        return transaction.SubCategory;
                    case TransactionGroupBy.DateDay:
                        return transaction.Date.ToString("yyyy/MM/dd");
                    case TransactionGroupBy.DateMonth:
                        return transaction.Date.ToString("yyyy/MM");
                    case TransactionGroupBy.DateYear:
                        return transaction.Date.ToString("yyyy");
                    case TransactionGroupBy.Name:
                        return transaction.Name;
                    case TransactionGroupBy.InputOutput:
                        return transaction.Value > 0 ? "Receita" : "Despesa";
                }
            }

            return null;
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
«Пена дней» — наиболее известный из романов французского писателя Бориса Виана (1947). Его экранизации:
 «Пена дней» — французская фантастическая драма 1968 года, режиссёр Шарль Бельмон.
 «Пена дней» — франко-бельгийский фильм 2013 года, режиссёр Мишель Гондри.

redpajama_set_name: RedPajamaWikipedia


As everyone knows, I'm going into this new year as a brand new mom. And since becoming a new mom I have had a little trouble adjusting. You think you've gone without sleep before but you are oh so wrong. You don't know exhausted until you've spent so many nights awake that you can't remember what day it is. Not to mention that on top of your exhaustion, there is a tiny human who requires your absolute, undivided attention and sometime despite your BEST efforts… they still cry. Maybe they just like to test your patience, who knows!
Having said all that, I am making it my goal this year to slow down. Take some time to enjoy my baby and all the adventures of being a brand new mom. I want to make sure I am striving to be a better me. This year that goal isn't for me, it's for Reagan because she needs me to be the best me that I can be. So I'm going to put more effort into reading my bible everyday, being more positive, and enjoying the little things.


text:
Discover Your New Favorite Soul Food Restaurant
Enjoy fried chicken, smothered pork chops and more in Buffalo, NY
Thank you for visiting the website of Margie's Soul Food. If you're looking for a casual, kid-friendly restaurant in Buffalo, NY, Margie's Soul Food is the place to be. We also offer takeout and catering services. If you have any questions about our restaurant, call 716-322-1748.
Margie's Soul Food
Copyright © 2023 Margie's Soul Food, all rights reserved.
999 Broadway Street, Buffalo, NY 14212 (716) 322-1748


text:
Q: problem with parsing string from excel file i have ruby code to parse data in excel file using Parseexcel gem. I need to save 2 columns in that file into a Hash, here is my code:

worksheet.each { |row|
  if row != nil
    key = row.at(1).to_s.strip
    value = row.at(0).to_s.strip

    if !parts.has_key?(key) and key.length > 0
      parts[key] = value
    end
  end
}

however it still save duplicate keys into the hash: "020098-10". I checked the excel file at the specified row and found the difference are " 020098-10" and "020098-10". the first one has a leading space while the second doesn't. I dont' understand is it true that .strip function already remove all leading and trailing white space?
also when i tried to print out key.length, it gave me these weird number:

020098-10 length 18
020098-10 length 17

which should be 9....

A: If you will inspect the strings you receive, you will probably get something like:
" \x000\x002\x000\x000\x009\x008\x00-\x001\x000\x00"

This happens because of the strings encoding. Excel works with unicode while ruby uses ISO-8859-1 by default. The encodings will differ on various platforms.
You need to convert the data you receive from excel to a printable encoding.
However when you should not encode strings created in ruby as you will end with garbage.
Consider this code:
@enc = Encoding::Converter.new("UTF-16LE", "UTF-8")

def convert(cell)
  if cell.numeric
    cell.value
  else
    @enc.convert(cell.value).strip
  end
end

parts = {}
worksheet.each do |row|
  continue unless row

  key = convert row.at(1)
  value = convert row.at(0)

  parts[key] = value unless parts.has_key?(key) or key.empty?
end

You may want change the encodings to a different ones.

A: The newer Spreadsheet-gem handles charset conversion automatically for you, to UTF-8 I think as standard but you can change it, so I'd recommend using it instead.

redpajama_set_name: RedPajamaStackExchange


At Audi Hunt Valley, we believe in providing you with premium customer service for the life of your vehicle. Whether it's a pleasurable and low pressure sales experience in our friendly showroom, or top-quality vehicle maintenance from our service department--we strive every day to make sure that you are a satisfied customer for life.
Located in Cockeysville (near the surrounding Towson, Baltimore and Parkville), Audi Hunt Valley is focused on a no-hassle and comfortable experience during your new or used car shopping venture. Our sales force is very knowledgeable about all Audi vehicles. Whether you're looking for a A4 for your daily commute or a Q5 to drive to Baltimore, our sales force will be able to provide you all the technical details you need to help you make an informative decision on your next purchase.
Looking for a top-notch service experience? Audi Hunt Valley is the best one-stop shop for all your maintenance and service needs for your Audi vehicle. Our service team consists of Audi-trained technicians that make servicing your new or used Audi very simple.
Live in the Cockeysville, Towson, Baltimore or Parkville area? Come experience a great sales or service experience at Audi Hunt Valley. Schedule a test-drive today!
Audi Hunt Valley serves the areas of Cockeysville, Baltimore, and Baltimore and not only provides new and pre-owned vehicles for your viewing pleasure, but also maintenance and repair services and financing. We are dedicated to having the Audi you want, such as the Audi A3 or Audi A4 for your daily commute, or the Audi Q5 or Audi Q7 for cruising around with the family. Spend your time well with our knowledgeable sales force and know that you'll walk away happy.
Explore our expansive selection of brand new Audi vehicles with no hassle or hurry. Audi Hunt Valley strives to make every customer experience pleasant and successful. Looking for a new Audi near you? Our vast inventory of new Audi models is sure to have one that you'll fall in love with and ultimately drive around Baltimore, Owings Mills, and Cockeysville for many years to come. From new models such as the Audi A5 or Audi A6 to the Audi Q3 or Audi A3 e-tron, Audi Hunt Valley has you covered.
Since all of Audi Hunt Valley pre-owned cars are processed through a certified Audi automotive specialist department, you know that you're getting a great pre-owned Audi in the Cockeysville area. Each pre-owned car is also given a multi-point inspection, and many are certified pre-owned. Looking for a used Audi near you? Audi Hunt Valley has an extensive pre-owned Audi inventory including many pre-owned Audi specials. Check out Audi Hunt Valley to find the perfect pre-owned Audi for you. And if you're looking to sell your car, we offer on-the-spot offers and same-day payment for your pre-owned vehicle.
Dropping off your Audi for maintenance or repairs at Audi Hunt Valley is a breeze. Looking for Audi service near you? This dealership has only factory-trained professional technicians on hand as well as an extensive selection of OEM Audi parts and Audi Genuine Accessories. Audi Hunt Valley will cover all of your Audi service needs in the Cockeysville area. Schedule an appointment today and get back out on the road in an efficient and timely manner.
Leasing the new Audi that you want has never been easier. Audi Hunt Valley provides a plethora of leasing options to get you behind the wheel of the new Audi that you've been looking for. Wondering whether to lease or finance a new Audi vehicle? Our finance specialists are capable and prepared to guide you through the process of financing the Audi you deserve. Audi Hunt Valley features an extensive inventory of new Audi models, as well as many exciting new Audi lease specials sure to help you get into the Audi of your dreams today!


3/2/2017 -- E&E Daily -- Congress. Legislation. Politics.
One of Alaska's richest men and a chief opponent of the controversial Pebble mine will meet with President Trump at the Mar-a-Lago resort in Palm Beach, Fla., sources said.


A touch of crisp, solid white adds sparkle to this sew-easy table runner.
Surround Four-Patch blocks with a trio of borders in a quick-to-make bed quilt. Fabrics are from the It's a Girl Thing color story collection by Michael Miller Fabrics.
Tone down the girly factor by narrowing the palette to burgundy red and gray. This quilt uses flannels that remind us of menswear woolens for this cozy version. The fabrics are from the Tailor collection by Timeless Treasures Fabrics and the Woolies flannel collection by Bonnie Sullivan for Maywood Studio.
Combine precut fabrics into strip sets and fashion a tote in a flash. Fabrics are from the Pom Pom de Paris collection by French General, Cabbages and Roses collection by Northcote Range, and Shangri-La cllection by Three Sisters for Moda Fabrics.
Whether it's a stand-alone gift or a gift bag, this sew-easy tote is sure to please. Cut icy strips for a winter blue tote or a pink-and-green strips for a girl-friendly one. Fabrics are from the Lux metallic collection from Timeless Treasures and the Princess and the Frog collection from Northcott.
Go to the free tote pattern.
Let a sweet print take center stage on a wall quilt with a handful of borders. Fabrics are from the Play Date collection by Dear Stella Fabrics.
A novelty print carries through to the border fabrics: cheerful polka dots, wonky dots, and stripes. Fabrics are from Peak Hour collection by Kellie Wulfsohn of Don't Look Now! for Riley Blake Designs, Mischief collection by Nancy Halvorsen for Benartex, and Backyard Baby collection by Patty Sloniger for Michael Miller Fabrics.


Today is all about indulging in your favorite candy AND I am definitely participating. Never feel guilty as long as you burn some calories before the debauchery begins. Spin class in the AM and Snickers in the PM. Happy Halloween!


Start your morning off with the perfectly balanced Columbia Supremo coffee. Known to be the best of Columbian coffee, our Supremo beans are medium bodied that is balanced with sweet, caramel notes that follows with a complimentary rich nutty flavor.
Is there a better reason to wake up?


text:
Drotrecogin (Handelsname: Xigris®, Hersteller: Lilly) ist eine rekombinante Form des natürlicherweise im Blutplasma vorkommenden aktivierten Protein C, rhAPC (rekombinantes aktiviertes Protein C), von dem es sich nur durch einzelne Oligosaccharide im Kohlenhydratteil des Moleküls unterscheidet. Drotrecogin gehört zu den Serinproteasen. Es war in der Intensivmedizin bei Erwachsenen im Fall einer schweren Sepsis mit multiplen Organversagen zusätzlich zur Standardtherapie gedacht und unter bestimmten Bedingungen empfohlen. Das Medikament wurde 2011 vom Markt genommen, nachdem die anfängliche positive Nutzen-Risiko-Bewertung nicht aufrechterhalten werden konnte.

Drotrecogin wird gentechnisch aus einer etablierten humanen Zelllinie hergestellt. Es unterscheidet sich von dem natürlicherweise im Plasma vorkommenden aktivierten Protein C durch einzelne an dieses Protein gebundene Oligosaccharide.

Wirkmechanismus
Die Eigenschaften von Drotrecogin sind mit denen des endogenen humanen aktivierten Protein C vergleichbar.
Das körpereigene Protein wirkt antithrombotisch, indem es die Faktoren Va und VIIIa blockiert. Über die Hemmung von PAI-1 fördert der Wirkstoff die Fibrinolyse. Aktiviertes Protein C unterdrückt zudem die Freisetzung der entzündungsfördernden Zytokine Interleukin-1 und TNF-α.

Marktrücknahme
Xigris wurde 2002 unter "außergewöhnlichen Umständen" zugelassen. Ein solches Verfahren wird angewendet, wenn der Antragsteller nachweisen kann, dass es nicht möglich ist umfassende Daten über die Wirksamkeit und Sicherheit des Arzneimittels vorzulegen, entweder aufgrund der Seltenheit der Erkrankung, begrenzter wissenschaftlicher Erkenntnisse in dem betreffenden Anwendungsgebiet oder ethischer Überlegungen. Die zu dem Zeitpunkt vorliegenden Ergebnisse der PROWESS-Studie (PROtein-C Worldwide Evaluation in Severe Sepsis) zeigten eine signifikante Verbesserung der 28-Tages-Gesamtmortalität. Die Studie an 1.690 Patienten mit schwerer Sepsis war daraufhin vorzeitig abgebrochen worden, die Zulassung wurde mit der Auflage für eine jährliche Neubewertung erteilt. 2007 befand die EMA, dass nachfolgende Studien die in der Pivot-Studie PROWESS gefundene Wirksamkeit nicht reproduzieren konnten und forderte weitere klinische Daten.

Eine im April 2011 veröffentlichte Cochrane-Analyse ergab, dass in weiteren fünf klinischen, randomisierten Studien kein signifikanter Überlebensvorteil für Patienten mit Sepsis durch die Behandlung mit Drotrecogin aufgezeigt wurde.

Nachdem 2011 die Ergebnisse einer Studie zur Behandlung des septischen Schocks (PROWESS-SHOCK-Studie) die Endpunkte verfehlten, wurde das positive Nutzen-Risiko-Verhältnis für Drotrecogin erneut in Frage gestellt. Der Hersteller Eli Lilly verkündete im Oktober 2011 die weltweite Einstellung des Verkaufs des Medikaments.

Einzelnachweise

Literatur
 V. Costa, J. M. Brophy: Drotrecogin alfa (activated) in severe sepsis: a systematic review and new cost-effectiveness analysis. In: BMC Anesthesiol. 7, 2007 Jun 25, S. 5. PMID 17592639;

Arzneistoff
Antikoagulans
Peptidase


text:
Institutional subscriber information
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Austin Health
Updated on January 7, 2020
Aarhus University/ Royal Danish Library
Updated on December 3, 2019
Bendigo Health
Norwegian Institute of Public Health (NIPH) (Norwegian: Folkehelseinstituttet - FHI)
Updated on July 1, 2020
HSE National Health Library & Knowledge Service
RCSI Bahrain
Updated on October 7, 2020
National Academies of Sciences, Engineering and Medicine
American Society for Gastrointestinal Endoscopy
Université d'Ottawa (en français)


Presents an account of the life and travels of Isabella Bird, celebrated English writer and explorer and the first female member of the Royal Geographical Society.
Bird, Isabella L. -- (Isabella Lucy), -- 1831-1904 -- Juvenile literature.
Bird, Isabella L. -- (Isabella Lucy), -- 1831-1904.
Women travelers -- Great Britain -- Biography -- Juvenile literature.
written by Lori Mortensen ; illustrated by Kristy Caldwell.
Add tags for "Away with words : the daring story of Isabella Bird". Be the first.
schema:about <http://experiment.worldcat.org/entity/work/data/4191051064#Place/great_britain> ; # Great Britain.


Take the Gentlemen's Hardware Urban Carabiner Multi-Tool with you wherever you may wander and you'll be prepared for almost any eventuality.
Tough and compact, this technical bit of kit has a built-in flat-head screwdriver, a keyholder, headphones tidy, a 6.5mm wrench, a carabiner clip and a bottle opener. Simply tuck it in your bag or desk drawer and you'll be always be efficient in the city! Presented in a branded gift box.


Yesterday, we showed you the latest video of the upcoming Gears of War: Ultimate Edition, which demonstrates one of the remade cutscenes from the original project. And today, we'd like to tell you about another instalment in this shooter series. Recently, Microsoft company has reported when the Gears of War 4 beta will start and how the players can get access to it.
As it's revealed, the Gears of War 4 beta on Xbox One will preliminary begin in spring 2016. However, already now, the fans of the franchise have an excellent chance to get early access to the forthcoming testing. All they have to do is to purchase a special bundle that includes the current-gen console from Microsoft and a copy of Gears of War: Ultimate Edition before March 1st, 2016. Besides, the gamers will have to be registered in Xbox Live and play the upgraded version of the famous shooter before the mentioned date as well. The bundle will be released this August.
Unfortunately, there's no additional information concerning how earlier the players, who will buy the edition, will be able to participate in the Gears of War 4 beta.
Let us remind you that the new part in the series will be launched in Q4 2016.
Are you interested in the Gears of War 4 beta? Would you like to take part in it?


Nusrat Fateh Ali Khan; Considered one of the greatest voices ever recorded, possessed an extraordinary range of vocal abilities and could perform at a high level of intensity for several hours. The magic of his voice is beyond analysis. He is said to have brought the classical singing to a common man through the medium of his Qawwali. Acclaimed throughout the world and bringing in tears of joys through his mesmerizing melodious voice, one does not need to know the words to understand the connection he brings out in Music. An acclaimed singer himself Jeff Burkley once said "…….his voice is velvet fire, simply incomparable. His every enunciation went straight into me. I knew not one word of Urdu, and somehow it still hooked me into the story that he weaved with his wordless voice".
For us all of the songs that have been sung are all class apart. But let us relive those 5 songs that make us feel the real greatness and the sheer Brilliance of this Once in a lifetime God given Talent.
Arguably Mast Mast , was probably the most popular and Loved NFAK song ever. Written by Hazrat Amir Khusrow (RA), then further modified by Hazrat Baba Bulleh Shah (RA) will bring out the spirituality in you.


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