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Biowizardry: Cauterizing the Bleeding Edge
of medicine, science and adaptation - especially neurology, immunology and related disabling conditions
Biowizardry: Cauterizing the Bleeding Edge » biomedicine
Category Archives: intestines
News flash: the gut and brain are connected!
By wp-admin | July 6, 2011 - 7:53 pm | July 6, 2011 biomedicine, endocrine modulation, immunity, inflammation, intestines, it's not imaginary, neuro tuning, neurotransmitters
The obvious scatological humor will be left alone. Guys, you know what I mean. (Girls who were outnumbered by your brothers, you too.)
I started to blog this article because the forehead-smacking tone of the revelation that the gut might relate to the brain was a bit too much for me. On closer examination, it looks like the misplaced drama is the writer's, not the scientists'.
One of the places where serotonin is released is in the gut, where it helps digest proteins. That's the most obvious "duh" moment here. Moreover, as those of us who remember our embryology know, the inter-relationships and constant correspondence between neurology and gut, gut and immunity, immunity and endocrine system, endocrine and neurological system are all too intense and interlocked for words.
Most studies make brutally clear that these so-called systems are medically treated as separate and distinct, but our bodies never got that memo. It's all the same system, as far as the body is concerned.
Much of this researcher's recent work focuses on neurology of the gut — enteric neurology. It's a real thing now. His prior work focused on the biological environment in the gut, or the intestinal microbiota.
// START Word geek goes wild:
Sometimes, I just love medical terminology for the way it rolls, hops, and bounces off the tongue. Enteric neurology. Intestinal microbiota. Hypothalamic-pituitary-adrenal axis.
Maybe that last one doesn't work so well.
// END Word geeking.
If you can stand the medical and chemical jargon, it's worth looking into some of his work. It's probably not a stretch to call it prescient, in that it is likely to lay the foundations for our emerging understanding of the gut as a more complex and self-managing, yet interlocked, set of systems than we've ever imagined before.
I can't find the original science article, just this unsatisfactory and superficial overview. It says that intestinal microbiota affect the person's mood and feelings, and that it's possible to deliver specific probiotics (like yogurt species, naturally-fermented cole slaw, certain cheeses and the like) in order to have a specific benefit to the neurological system.
If you were an empiricist, like me, it would sound like "eating good, living food leads to better mental health," which healers have been saying for millenia. But far be it from me to steal such well-researched thunder.
Link list:
Science Daily article:
A Gut-Full of Probiotics for Your Neurological Well-Being
Credentials of lead researcher, Prof. Lyte:
Mark Lyte, Ph.D., M.S., MT (ASCP)
Wikipedia's digest (sic) of the enteric nervous system (this seems basically congruent with the uber-geeky medical studies I looked at on the subject, so I accept it as a decent primer):
Enteric Nervous System
Couldn't find a good overview that didn't involve more dead rodents than I could, er, stomach.
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Get Clear Before School's Here!
Acne occurs when our pores become clogged. Each pore opens to a follicle, which contains a hair and an oil gland. The oil released by the gland helps remove old skin cells and keeps your skin soft. When glands produce too much oil, the pores can become blocked, and dirt, bacteria, and cells build up causing acne.
Although acne is most common in teenagers, anyone can get acne and it can last into middle age. Hormonal changes may cause the skin to become more oily. Scarring may occur if severe acne is not treated. Some people, especially teenagers, can even become depressed if acne is not treated.
A good skin care regimen is important in preventing breakouts, as is the use of non-comedogenic oil-free makeup. Although there are multiple topical and oral treatments that can help, it can take time for them to take effect. Luckily there are light and laser treatments that can help. One can do these treatments alone or in conjunction with topicals and oral medicines to increase the effectiveness of treatment and prevent future breakouts that may result in scarring.
We are happy to be able to offer multiple different treatment options. If downtime is not an option, a combination blue and red light treatment that takes a total of 15 minutes can be done. The combination treatment aids in both decreasing the redness, as well as the bacterial byproduct responsible for aggravating acne.
We are also excited to offer Isolaz treatments, which use suction combined with a light device, to both clean the pores that become blocked in acne, while delivering gentle heat to the skin. The treatment takes 10 minutes and leaves the skin feeling clean, tight and refreshed.
Photodynamic therapy (PDT) is a very effective procedure that uses a photosensitizing drug to apply light therapy selectively to target the oil glands responsible for causing acne. Treatment shrinks the oil gland, therefore decreasing oil production and thereby acne. In our practice, we use a combination of two different laser devices, and 2 light sources to perform the procedure, which also aids in evening out skin tone and improving skin texture typically after just one treatment.
If scarring has already occurred from the previous acne, there is hope. Lasers are able to penetrate deeper into the skin, where scarring occurs, to stimulate new collagen production and improve the overall texture and appearance of acne scars. Fillers can also be used to fill certain types of acne scars, making them practically imperceptible. Feel free to schedule a free consultation for more information.
Next, read our blog, What is the Best Laser to Rejuvenate My Skin?


Dave and I have lived in a few places (Minot, ND; Kokomo, IN; Sioux City, IA; Norfolk, NE; Denver-forever), different houses. And my parents have been all over since I left their home, too (Hobart, IN; Willard, OH; Richmond, IN; St Joe-MO; Butte, MT; Springfield, MO; back to St Joe-MO). I visited my parents in their current digs in Saint Joe early in the year. The house they are living in? Not home. No. But my parents? Wherever they land, is kinda home to parts of me. I always need to know where they are and what their house looks like so I will know the space my heart is rambling about in. Mom and dad are the fixed stars in my sky. LOVE them!
While we were at the Moslander Family Reunion last week in Chicago and Northwest Indiana, us old-timers took a late-afternoon, impromptu drive through the old neighborhoods; saw places we had worked and schools we'd attended and the house we called home. It is all the same, but so different. The huge mountain spruce in the fron yard at 4995 Roosevelt Place, trimmed to above roofline and barely clinging to life now, was once a full, thick, green privacy wall between the house and street. There are pictures there of my brothers in their graduation attire and even my babies running on the lawn from way back when. The juniper has all been removed in favor of more manageable potted flora. The dings Tim and my other brothers put into the side of the house playing baseball in the 70's are still there, a testament to long summer days spent with a bat and ball in hand.
And we actually were just a few blocks from the Jackson family home in Gary, Indiana, btw!
The streets of Gary used to be positively frightening during business hours, the traffic heavier than the city had prepared for. The business district I used to drive is nearly a ghost town. Boarded up windows and abandoned buildings everywhere, yet minutes away, there are still quiet neighborhoods with established lawns and trees. You can buy a beautiful brick bungalow for $15,000 (the for sale signs made of cardboard and black marker) there on an empty street. The same would cost 1.3 million in Denver.
Surprisingly, standing there in the old yard, looking at the house in conjunction with neighboring homes and recalling old times and people from the past, it didn't seem smaller. Often you'll return to a childhood haunt and you'll just feel like, "Wow-this seems so small now." But that wasn't the case at the Roosevelt Street house, the last home we all shared under one roof, the place my kids remember going to see Grandma and Grandpa Moslander. It really didn't seem smaller.
It just seemed like: wow-how did this house ever hold all the life and loud love and laughter and memory and family and patio swimming in a 12-foot pool and Uno, all the huge bags full of 19-cent White Castle burgers after church ball games, or Bronco's Pizza with 5 pounds of melted, dripping, greasy cheese, and church friends and Lake-effect wind and graduations and marriages and teen-agers and letter writing and boyfriends and girlfriends and Lake-effect snow and family altar and family feuds and kids and toys and books and WGN afternoon movies with our first color TV, first jobs and rusted out cars and Tip Top and Bible study and early morning prayer and first grandchildren and the first few spouses and all the rest of living that the Moslander family brought to it?
How on earth did this modest house on this unicorporated county street handle all that?
And it yet stands as a testament.
The Moslanders were here June 1977 – Spring 1990. And again in June 27, 2011. We were here.
I stumbled across your website and it made me smile. I was born and raised in Hobart, graduating high school in 1974. I moved away to go to college, then moved around the country working in more states than I can remember. But I do go back to the region about once a year to visit my bro who STILL lives in Hobart and STILL works at US Steel.
This past spring while I was in Hobart for the celebration of my Mom's life, I drove past my old house on Linda Street. It was a cool experience. The lady who lived there even came out and invited me inside, but it felt weird and I declined. Now I wish I would have gone in.


text:
[% page.banner = "February 7, 2001 - YAPC::Europe CFP Dealine June 1, 2001" %]
[% page.title = page.banner %]

YAPC::Europe's Call for Participation will end on June 1, 2001. If you
are interested in speaking, please visit the CFP web page for more
detailed information.

Talks can be:

180 minute tutorials

90, 40 or 25 minute talks

5 minute lightning talk

redpajama_set_name: RedPajamaGithub


The Visby Contemporary Rectangular Cocktail Table by Magnussen Home at Darvin Furniture in the Orland Park, Chicago, IL area. Product availability may vary. Contact us for the most current availability on this product.
The Visby collection is a great option if you are looking for Contemporary furniture in the Orland Park, Chicago, IL area.
Browse other items in the Visby collection from Darvin Furniture in the Orland Park, Chicago, IL area.


text:
Q: Verify files not in use before attempting to delete a folder on the network Set fso = CreateObject("Scripting.FileSystemObject")
BazKlasor = "\\SRV01\l.urge\01 IS TAKIP\11 BAZ"
ArsivKlasor = "\\SRV01\l.urge\80 ARSIV\01 IS TAKIP\11 BAZ"

arsiveGonKlasor = BazKlasor & "\" & Me.FR15_cmb01.Value

If fso.folderexists(arsiveGonKlasor) Then
   fso.CopyFolder arsiveGonKlasor, ArsivKlasor & "\"
   fso.deletefolder arsiveGonKlasor
Else
   MsgBox Me.FR15_cmb01.Value & " KLASÖRÜ BULUNAMADI. İŞLEM SONLANDIRILIYOR", vbCritical, "L.URGE"
   Call sifrekapat
   Exit Sub
End If

I can delete a folder on the network with the code above.
If someone is working on the files in the folder, I get an error. How can I check this before I start deleting?

A: Instead of trying to check whether someone is using a file in the folder, it would be simpler to use error handling to attempt deletion of the folder, catching the error and doing something useful if it fails. For example:
   On Error GoTo ErrorHandler   ' Enable error-handling routine.

   Set fso = CreateObject("Scripting.FileSystemObject")
   BazKlasor = "\\SRV01\l.urge\01 IS TAKIP\11 BAZ"
   ArsivKlasor = "\\SRV01\l.urge\80 ARSIV\01 IS TAKIP\11 BAZ"

   arsiveGonKlasor = BazKlasor & "\" & Me.FR15_cmb01.Value

   If fso.folderexists(arsiveGonKlasor) Then
      fso.CopyFolder arsiveGonKlasor, ArsivKlasor & "\"
      fso.deletefolder arsiveGonKlasor
   Else
      MsgBox Me.FR15_cmb01.Value & " KLASÖRÜ BULUNAMADI. İŞLEM SONLANDIRILIYOR", vbCritical, "L.URGE"
      Call sifrekapat
      Exit Sub
   End If

   MsgBox "Delete worked!"

   Exit Sub

ErrorHandler:    ' Error-handling routine.
   MsgBox "Delete failed! Error: " & Err.Number & " : " & Err.Description

   'Do something useful here

redpajama_set_name: RedPajamaStackExchange


text:
namespace Reversi {
    class Disc {
        public static Controller controller;

        private Controller.Colors color;

        private Position position;

        public Controller.Colors Color {
            get {
                return this.color;
            }

            set {
                this.color = value;
            }
        }

        public Position Position {
            get {
                return this.position;
            }

            set {
                this.position = value;
            }
        }

        /**
         * The constructor of the disc class. Does not change other discs when added.
         *
         * Parameters
         * Position position       - The position of the disc
         * Controller.Colors color - The colour of the disc
         */
        public Disc(Position position, Controller.Colors color) {
            this.color    = color;
            this.position = position;

            // Add the disc to the board
            controller.AddDisc(this);
        }

        /**
         * The constructor of the disc class.
         *
         * Parameters
         * Position position       - The position of the disc
         * Controller.Colors color - The colour of the disc
         */
        public Disc(Position position) {
            this.color    = controller.Active;
            this.position = position;

            // Add the disc to the board and update the neighbours
            controller.SetDisc(position, this);
        }
    }
}


text:
My Prisoner
Hardcover, FSG Originals, 2014
Joshua Davis
more about author
Four undocumented Mexican American students, two great teachers, one robot-building contest . . . and a major motion picture
In 2004, four Latino teenagers arrived at the Marine Advanced Technology Education Robotics Competition at the University of California, Santa Barbara. They were born in Mexico but raised in Phoenix, Arizona, where they attended an underfunded public high school. No one had ever suggested to Oscar, Cristian, Luis, or Lorenzo that they might amount to much—but two inspiring science teachers had convinced these impoverished, undocumented kids from the desert who had never even seen the ocean that they should try to build an underwater robot.
And build a robot they did. Their robot wasn't pretty, especially compared to those of the competition. They were going up against some of the best collegiate engineers in the country, including a team from MIT backed by a $10,000 grant from ExxonMobil. The Phoenix teenagers had scraped together less than $1,000 and built their robot out of scavenged parts. This was never a level competition—and yet, against all odds . . . they won!
But this is just the beginning for these four, whose story—which became a key inspiration to the DREAMers movement—will go on to include first-generation college graduations, deportation, bean-picking in Mexico, and service in Afghanistan.
Joshua Davis's Spare Parts is a story about overcoming insurmountable odds and four young men who proved they were among the most patriotic and talented Americans in this country—even as the country tried to kick them out.
Read More + Read Less -
An excerpt from Spare Parts
Lorenzo Santillan had always been different. It might have been his head. When he was a few months old, his mother dropped him on a curb in Zitácuaro, a town of about 100,000 people in the Mexican state of Michoacán. He already had an odd, pear-shaped head, but now he developed a lump on his forehead. Laura Alicia Santillan was worried. She decided that he needed better medical attention than he was getting in Mexico, so she began the long journey to the United States, eventually slinking through a tunnel under the border with Lorenzo in 1988. Lorenzo was nine months old. She was motivated by a simple desire.
"We came to the U.S. to fix his head," she says.
She found a doctor in Phoenix who agreed to examine her son. The man said that surgery could realign Lorenzo's skull, but with a significant risk of brain damage. But, as far as the doctor could tell, Lorenzo was doing fine. The surgery would be strictly cosmetic and was otherwise unnecessary. Laura took another look at the bump above her son's right eyebrow and saw it in a new light. From that moment on, she told Lorenzo that the bump meant he was smart. "Your extra brains are in there," she told her son.
Now that Laura and Lorenzo were in the United States, there were reasons to stay. Th e family had barely been getting by in Mexico. After slicing off half of his right index finger in a carpentry accident, Pablo Santillan, Lorenzo's father, fed the family by disappearing into the forest for days on end with an ancient musket. He would return with skunks, squirrels, and iguanas slung over his shoulder. Laura dumped them into a stew, added some tomato, chili, and onion, and called it dinner. She was only fourteen when she married Pablo (he was twenty), and neither had made it past sixth grade. There weren't a lot of opportunities in Zitácuaro, but in the United States, Pablo had a shot at making five dollars an hour as a gardener. It seemed worth relocating.
The family moved into a two-room apartment near downtown Phoenix. A block away, prostitutes offered their services from an abandoned building. Drug dealers worked the corners. It was starkly different from Zitácuaro, where Pablo could search the forest for food. Now they lived in the middle of a big city and it wasn't possible to hunt for dinner. Laura got intermittent work as a hotel maid, and Pablo worked landscaping jobs throughout the scorching Arizona summer.
Before coming to the United States, Laura had given birth to two children: Lorenzo and his older brother, Jose. When she crossed over to the United States, she was pregnant and soon gave birth to Pablo, Jr., on U.S. soil, which meant that her third child became an American citizen. Yoliet and Fernando, a daughter and a son, were also born in the United States. The three American-born siblings would go on to have significantly more opportunities to live and work in the United States than the two who had adopted the country as their new home.
For Laura, Mexico soon became "an erased memory." But Pablo never forgot the solitude of the Mexican forest. A quiet, stoic man, he wore cowboy boots and sported a handlebar mustache so thick, it hid his mouth. He had the hard-drinking, solitary nature of a cowboy but now found himself in a vast urban desert with five children. It was a heavy load to bear. At night and on weekends, he oft en bought a twelve-pack of Milwaukee's Best and started working his way through it. As Lorenzo tells it, when Pablo was drunk, he became emotional. Sometimes he told Lorenzo that he loved him, other times he snapped. On one occasion, when Lorenzo was in middle school, Pablo asked his son to clean up the living room. When Lorenzo refused, Pablo grabbed an electrical extension cord and went after him.
School wasn't much better. As Lorenzo got older, his jowls bulged out but the top of his head stayed comparatively narrow, giving it an egg shape. Kids mocked him for his misshapen head and, once he got to middle school, they laughed at his unibrow. "I didn't understand why people would do that," Lorenzo says. Many days, he came home crying. With little choice, Lorenzo decided to embrace the fact that he was different. While the other kids at school had short hair and nice fades, Lorenzo went the other way. His mother cut his hair—they couldn't afford a barber—so he asked her to only trim his bangs and let the rest of his hair grow out. Soon, he had a mullet.
"It looks really nice," Laura told her son.
His classmates were less supportive; the ridicule was frequent and varied. Sometimes they called him an egghead; other times, he was referred to as El Buki, after a long-haired Mexican pop singer. When students called him a woman, he fired back that he was more of a man because he could take all the insults. "I don't want to be like everyone else!" he yelled back, and tried to pretend it didn't hurt.
In seventh grade, a friend asked him to carry marijuana for Sur Trece, a local gang associated with the Crips. He agreed and was entrusted with a pound of weed, which he stashed in his backpack. Eventually, he was instructed to leave it in a hole on school grounds. He did as he was told but was terrified the whole time. "I could get my ass kicked at any moment," he kept thinking. He realized he wasn't cut out to be a criminal and refused to do it again.
Instead, when he arrived as a freshman at Carl Hayden Community High School, he decided to join the marching band. To prepare him, his mother found a piano program offered by the Salvation Army and managed to get a free upright piano (though it was missing a number of keys). She set it up on the back patio so he could practice. Lorenzo learned how to play pieces by Debussy ("Clair de lune"), Erik Satie (Gymnopédie no. 3), and Chopin (Sonata no. 2). Lorenzo could listen to the music a few times and then play it back. He figured he was learning enough that he could wing it at band practice.
Unfortunately, band practice is not a place where winging it works. The first problem was that the band had no piano. The closest thing the music teacher could come up with was the xylophone. Next, Lorenzo had no idea what to play since he couldn't read the sheet music.
Nonetheless, as Christmas neared, the teacher handed him a uniform and hat and told him to get ready for the annual holiday parade. Lorenzo dutifully donned the outfit, strapped the hulking xylophone to his body, and marched alongside the rest of the band as they paraded down Central Avenue in downtown Phoenix. He knew the songs they were performing had big parts for the xylophone, but he couldn't play them. Every now and then he would try to hit a few notes, but they were always wrong. As the parade streamed endlessly through downtown Phoenix, he kept wondering when the humiliation would be over. The best he could do was keep his legs in time with the others as they walked.
"It was a walk of shame," he says.
He returned the xylophone and never went back to band. He felt that he didn't belong anywhere, though he was desperate to find friends, or at least people who wouldn't mock him. But it was high school and he looked funny. He had also been held back a year in first grade when he was still learning English. As a result, he was a year older than his classmates, which suggested he had flunked a grade.
Lorenzo tried to reason with his hecklers. When he mispronounced a word in English and kids laughed, he pleaded for some sympathy: "Why you gotta make fun of me for something I meant?" That only produced more laughter.
Lorenzo's anger mounted and he started picking fights at school. He ended up bruised, scraped, and in the principal's office. He was on track to be expelled. In an effort to turn him around, the school counselor assigned him to anger-management class. He learned that his anger was explosive, the most dangerous type. If he didn't rein it in, he would self-destruct. The counselor showed him how to calm himself by counting backward from ten. Th e problem was, he wasn't sure he wanted to calm himself. It was hard to ignore all the teasing.
After school, Lorenzo started helping his godfather fix cars. Hugo Ceballos lived with the Santillan family and had set up an informal business in their driveway; anybody with car problems could pull in and Hugo would pop the hood, figure out what was wrong, and fix it right there.
Hugo wouldn't let Lorenzo do much more than clean the tools with a rag damp with gasoline. It gave Lorenzo an excuse to stand beside the cars and watch. He learned that when you jack up a car, you should position a tire on the ground beside you when you slide under the vehicle. That way, if the jack fails, the car will land on the tire, not you.
That's a badass idea, Lorenzo thought.
Lorenzo wanted to do more, but Hugo didn't let him. So Lorenzo hovered on the periphery, cleaning the occasional tool and watching closely as Jose, his older brother, helped. Hugo explained to Jose that it was important to keep track of all your parts. "Anything you take off a car, remember where it goes," he told Lorenzo's brother. When Hugo installed a rebuilt engine, Lorenzo stood a few feet back and listened as Hugo showed Jose how to use a torque wrench to tighten the bolts. Lorenzo listened carefully and tried to get as close as he could to the car. He had to be careful though; if he got in Hugo's or Jose's way, he'd get yelled at and told to go inside.
The chief lesson Lorenzo learned was that it was important to be creative. Hugo wasn't running a normal mechanic's shop, with a wall full of tools and shelves filled with supplies. He had little money, a small set of hand tools, and his ingenuity. To survive, he had to come up with fresh ideas and adapt.
Lorenzo took that to heart. He didn't fit into white American culture and couldn't find his place in the immigrant community. Even band—the standard home for high school misfits—didn't work for him. But his days looking over Hugo's shoulder in the driveway had taught him to think outside the norm. In the driveway, an unusual idea wasn't necessarily bad. In fact, it might be the only solution.
"Perhaps the most gripping popular-science book I have read."
Noel Sharkey, Nature
"A great feel-good tale of scrappy underdogs beating long odds. But there's more to the story, and Spare Parts illuminates the human side of two polarizing political issues: immigration and education . . . Spare Parts is a delightful book . . . A great American story."
Peter Carlson, The Washington Post
"Spare Parts is an unforgettable tale of hope and human ingenuity. Against a backdrop of urban desert decay, a faltering school system, and our country's cutthroat immigration policies, Joshua Davis offers a moving testament to how teamwork, perseverance, and a few good teachers can lift up and empower even the humblest among us."
Héctor Tobar, author of Deep Down Dark
"It's the most American of stories: how determination and ingenuity can bring triumph over long odds. There are too few stories like these written about Latino students. Poignant and beautifully told, Spare Parts makes you feel their frustration at the obstacles and indignities faced by Cristian, Lorenzo, Luis, and Oscar--and to cheer as they rise to overcome each one of them. "
Sonia Nazario, author of Enrique's Journey
"Spare Parts is one of those rare stories that grabs hold and doesn't let go. It's hilarious, sad, and beautifully told. It will make you think hard about what it means to be American and where we will find the next generation of talent."
Chris Anderson, author of The Long Tail
"This is hands down my favorite kind of story: underdogs plus ingenuity plus pluck and dedication equals a deeply moving and touching narraitive. I love these kids!"
Adam Savage, cohost of MythBusterst
"This is important reading."
Noel Sharkey, Nature"A great feel-good tale of scrappy underdogs beating long odds. But there's more to the story, and Spare Parts illuminates the human side of two polarizing political issues: immigration and education . . . Spare Parts is a delightful book . . . A great American story."

redpajama_set_name: RedPajamaCommonCrawl


text:
Ion selectivity and activation of the M2 ion channel of influenza virus
Kiyoshi Shimbo, Diana L. Brassard, Robert A. Lamb, Lawrence H. Pinto*
The influenza A virus-associated M2 ion channel is generally believed to function during uncoating of virions in infected cells. On endocytosis of a virion into the lumen of endosomes, the M2 ion channel is thought to cause acidification of the virion interior. In addition, the influenza virus M2 ion channel is thought to function in the exocytic pathway by equilibrating the pH gradient between the acidic lumen of the trans-Golgi network and the neutral cytoplasm. A necessary test of the proposed roles of the influenza virus M2 ion channel in the virus life cycle is to show directly that the M2 ion channel conducts protons. We have measured the ionic selectivity and activation of three subtypes (Udorn, Weybridge, and Rostock) of the M2 ion channel in oocytes of Xenopus laevis by measurement of 1) the intracellular pH (pH(in)) of voltage-clamped oocytes, 2) the current-voltage relationship in solutions of various pH and ionic composition, and 3) the flux of 86Rb. We took advantage of the low pH(in) achieved during incubation in low pH medium to study the effects of low pH(in) on M2 activation. Oocytes expressing each of the three subtypes of the M2 protein a) underwent a slow acidification when incubated in medium of low pH (acidification was blocked by the M2 ion channel inhibitor, amantadine); b) had current-voltage relationships that shifted to more positive values and had greater conductance when the pH(out) was lowered (this relationship was modified when Na+ was replaced by NH4+ or Li+); c) had an amantadine-sensitive influx of Rb+. The effects on the current-voltage relationship of reduced pH(in) were opposed to the increased conductance found with reduced pH(out). We interpret these results to indicate that the M2 ion channel is capable of conducting H+ and that other ions may also be conducted. Moreover, the channel conductance is reduced by decreased pH(in). These findings are consistent with the proposed roles of the M2 protein in the life cycle of influenza A virus.
https://doi.org/10.1016/S0006-3495(96)79690-X
10.1016/S0006-3495(96)79690-X
Dive into the research topics of 'Ion selectivity and activation of the M2 ion channel of influenza virus'. Together they form a unique fingerprint.
Orthomyxoviridae Medicine & Life Sciences 100%
Ion Channels Medicine & Life Sciences 97%
Ions Medicine & Life Sciences 81%
Virion Medicine & Life Sciences 25%
Oocytes Medicine & Life Sciences 25%
Amantadine Medicine & Life Sciences 24%
Influenza A virus Medicine & Life Sciences 19%
Life Cycle Stages Medicine & Life Sciences 19%
Shimbo, K., Brassard, D. L., Lamb, R. A., & Pinto, L. H. (1996). Ion selectivity and activation of the M2 ion channel of influenza virus. Biophysical Journal, 70(3), 1335-1346. https://doi.org/10.1016/S0006-3495(96)79690-X
Shimbo, Kiyoshi ; Brassard, Diana L. ; Lamb, Robert A. ; Pinto, Lawrence H. / Ion selectivity and activation of the M2 ion channel of influenza virus. In: Biophysical Journal. 1996 ; Vol. 70, No. 3. pp. 1335-1346.
@article{1ed0b3e77df0456390ccaddc5d62ffc8,
title = "Ion selectivity and activation of the M2 ion channel of influenza virus",
abstract = "The influenza A virus-associated M2 ion channel is generally believed to function during uncoating of virions in infected cells. On endocytosis of a virion into the lumen of endosomes, the M2 ion channel is thought to cause acidification of the virion interior. In addition, the influenza virus M2 ion channel is thought to function in the exocytic pathway by equilibrating the pH gradient between the acidic lumen of the trans-Golgi network and the neutral cytoplasm. A necessary test of the proposed roles of the influenza virus M2 ion channel in the virus life cycle is to show directly that the M2 ion channel conducts protons. We have measured the ionic selectivity and activation of three subtypes (Udorn, Weybridge, and Rostock) of the M2 ion channel in oocytes of Xenopus laevis by measurement of 1) the intracellular pH (pH(in)) of voltage-clamped oocytes, 2) the current-voltage relationship in solutions of various pH and ionic composition, and 3) the flux of 86Rb. We took advantage of the low pH(in) achieved during incubation in low pH medium to study the effects of low pH(in) on M2 activation. Oocytes expressing each of the three subtypes of the M2 protein a) underwent a slow acidification when incubated in medium of low pH (acidification was blocked by the M2 ion channel inhibitor, amantadine); b) had current-voltage relationships that shifted to more positive values and had greater conductance when the pH(out) was lowered (this relationship was modified when Na+ was replaced by NH4+ or Li+); c) had an amantadine-sensitive influx of Rb+. The effects on the current-voltage relationship of reduced pH(in) were opposed to the increased conductance found with reduced pH(out). We interpret these results to indicate that the M2 ion channel is capable of conducting H+ and that other ions may also be conducted. Moreover, the channel conductance is reduced by decreased pH(in). These findings are consistent with the proposed roles of the M2 protein in the life cycle of influenza A virus.",
author = "Kiyoshi Shimbo and Brassard, {Diana L.} and Lamb, {Robert A.} and Pinto, {Lawrence H.}",
note = "Funding Information: This research was supported by Public Health Service Research grants AI-20201 (RAL) and AI-31882 (LHP) from the National Institute of Allergy and Infectious Diseases. KS was supported by a fellowship from ARVO/JNSPB. RAL is an Investigator of the Howard Hughes Medical Institute.",
doi = "10.1016/S0006-3495(96)79690-X",
journal = "Biophysical Journal",
publisher = "Biophysical Society",
Shimbo, K, Brassard, DL, Lamb, RA & Pinto, LH 1996, 'Ion selectivity and activation of the M2 ion channel of influenza virus', Biophysical Journal, vol. 70, no. 3, pp. 1335-1346. https://doi.org/10.1016/S0006-3495(96)79690-X
Ion selectivity and activation of the M2 ion channel of influenza virus. / Shimbo, Kiyoshi; Brassard, Diana L.; Lamb, Robert A.; Pinto, Lawrence H.
In: Biophysical Journal, Vol. 70, No. 3, 03.1996, p. 1335-1346.
T1 - Ion selectivity and activation of the M2 ion channel of influenza virus
AU - Shimbo, Kiyoshi
AU - Brassard, Diana L.
AU - Lamb, Robert A.
AU - Pinto, Lawrence H.
N1 - Funding Information: This research was supported by Public Health Service Research grants AI-20201 (RAL) and AI-31882 (LHP) from the National Institute of Allergy and Infectious Diseases. KS was supported by a fellowship from ARVO/JNSPB. RAL is an Investigator of the Howard Hughes Medical Institute.
N2 - The influenza A virus-associated M2 ion channel is generally believed to function during uncoating of virions in infected cells. On endocytosis of a virion into the lumen of endosomes, the M2 ion channel is thought to cause acidification of the virion interior. In addition, the influenza virus M2 ion channel is thought to function in the exocytic pathway by equilibrating the pH gradient between the acidic lumen of the trans-Golgi network and the neutral cytoplasm. A necessary test of the proposed roles of the influenza virus M2 ion channel in the virus life cycle is to show directly that the M2 ion channel conducts protons. We have measured the ionic selectivity and activation of three subtypes (Udorn, Weybridge, and Rostock) of the M2 ion channel in oocytes of Xenopus laevis by measurement of 1) the intracellular pH (pH(in)) of voltage-clamped oocytes, 2) the current-voltage relationship in solutions of various pH and ionic composition, and 3) the flux of 86Rb. We took advantage of the low pH(in) achieved during incubation in low pH medium to study the effects of low pH(in) on M2 activation. Oocytes expressing each of the three subtypes of the M2 protein a) underwent a slow acidification when incubated in medium of low pH (acidification was blocked by the M2 ion channel inhibitor, amantadine); b) had current-voltage relationships that shifted to more positive values and had greater conductance when the pH(out) was lowered (this relationship was modified when Na+ was replaced by NH4+ or Li+); c) had an amantadine-sensitive influx of Rb+. The effects on the current-voltage relationship of reduced pH(in) were opposed to the increased conductance found with reduced pH(out). We interpret these results to indicate that the M2 ion channel is capable of conducting H+ and that other ions may also be conducted. Moreover, the channel conductance is reduced by decreased pH(in). These findings are consistent with the proposed roles of the M2 protein in the life cycle of influenza A virus.
AB - The influenza A virus-associated M2 ion channel is generally believed to function during uncoating of virions in infected cells. On endocytosis of a virion into the lumen of endosomes, the M2 ion channel is thought to cause acidification of the virion interior. In addition, the influenza virus M2 ion channel is thought to function in the exocytic pathway by equilibrating the pH gradient between the acidic lumen of the trans-Golgi network and the neutral cytoplasm. A necessary test of the proposed roles of the influenza virus M2 ion channel in the virus life cycle is to show directly that the M2 ion channel conducts protons. We have measured the ionic selectivity and activation of three subtypes (Udorn, Weybridge, and Rostock) of the M2 ion channel in oocytes of Xenopus laevis by measurement of 1) the intracellular pH (pH(in)) of voltage-clamped oocytes, 2) the current-voltage relationship in solutions of various pH and ionic composition, and 3) the flux of 86Rb. We took advantage of the low pH(in) achieved during incubation in low pH medium to study the effects of low pH(in) on M2 activation. Oocytes expressing each of the three subtypes of the M2 protein a) underwent a slow acidification when incubated in medium of low pH (acidification was blocked by the M2 ion channel inhibitor, amantadine); b) had current-voltage relationships that shifted to more positive values and had greater conductance when the pH(out) was lowered (this relationship was modified when Na+ was replaced by NH4+ or Li+); c) had an amantadine-sensitive influx of Rb+. The effects on the current-voltage relationship of reduced pH(in) were opposed to the increased conductance found with reduced pH(out). We interpret these results to indicate that the M2 ion channel is capable of conducting H+ and that other ions may also be conducted. Moreover, the channel conductance is reduced by decreased pH(in). These findings are consistent with the proposed roles of the M2 protein in the life cycle of influenza A virus.
U2 - 10.1016/S0006-3495(96)79690-X
DO - 10.1016/S0006-3495(96)79690-X
JO - Biophysical Journal
JF - Biophysical Journal
Shimbo K, Brassard DL, Lamb RA, Pinto LH. Ion selectivity and activation of the M2 ion channel of influenza virus. Biophysical Journal. 1996 Mar;70(3):1335-1346. https://doi.org/10.1016/S0006-3495(96)79690-X


The first Provincial organization, The Natural History Society of British Columbia, was formed in 1890, to encourage "a more organized approach to the study of the natural features of the province". This group dissolved around the time of World War I and the idea of a Province-wide group was not taken up again for forty years.
In 1957 the government had just created a Department of Recreation and Conservation and this encouraged the three natural history clubs, Vernon (North Okanagan Naturalists Club), Victoria and Vancouver, to discuss the formation of a federation. It was not until 1963, however, that a group of eminent naturalists formed The British Columbia Nature Council. Founding members included Dr. Armstrong, Dr G.C. Carl, Dr V.C. Brink, Mr Jack Neild, Dr R. Stace-Smith, Mr Eric Garman, Mrs Gladys Soulsby and Mrs H. Lamoureux. Dr T.M.C. Taylor became the first President on May 11 1963. The B.C. Nature Council was composed of seven natural history clubs and had 1555 members.
On June 3, 1969, under the chairmanship of Dr. Stace-Smith, the Council incorporated under the Societies' Act, changing its name in the process to the Federation of British Columbia Naturalists ("Council" is reserved for government bodies.) The founding member clubs were: Central Okanagan, Comox-Strathcona, Cowichan Valley, North Okanagan, Prince George, South Okanagan, Thetis Park Nature Sanctuary, Vancouver Natural History Society and Victoria Natural History Societies.
The Federation of British Columbia Naturalists remains our legal name, but in 2006 we adopted the operating name, BC Nature, as more easily understood by the public and a clearer brand. BC Nature has always been active in the fields of conservation, education, and outdoor recreation. Since 1964 camps have been held regularly and have always proved popular. The B.C. Nest Record Scheme has been in operation since 1966 and for twenty years was co-ordinated by Vi Gibbard, a founding member of the South Okanagan Naturalists. Members throughout the Province take part in the Christmas Bird Count. The B.C. Naturalist magazine (now BCnature), published since 1964, keeps members up to date on the organization's activities, and BCN workshops, videos, books and posters have educated hundreds of members and non-members through the years.


Download Entry Level Customer Service Cover Letter 40 Inspirational Customer Service Cover Letter Template for Word, learn how to write a great resume, and examine sample resumes. Entry Level Customer Service Cover Letter 40 Inspirational Customer Service Cover Letter Template posted by admin at 2018-11-08 06:37:46. Simply select your and get started. Just scroll down and locate a Microsoft Word template fitting your projects experience and sense of design. Techniques – running a template is perfectly acceptable. When trying to find a fresh job you will need to develop a entry level customer service cover letter. After creating your resume, you can just buy a Entry Level Customer Service Cover Letter with your design, fonts, and color theme to make a professional job application. You're able to download any of these resume templates at no cost and add the bullet points yourself, or that you can certainly produce a resume in minutes with entry level biology degree jobs,entry level c programmer,entry level cyber security jobs,entry level developer jobs,entry level e bike,entry level jobs,entry level jobs for biology majors,entry level jobs in nyc,entry level jobs melbourne,entry level kpmg jobs,entry level online jobs,entry level political science jobs,entry level quality engineer salary,entry level r jobs,entry level veterinary assistant resume,entry level video camera,entry level video game jobs,entry level xc mountain bike,entry level xeon,entry level zoologist salary, .


Roll Labels are a great way to create to brand your product. You can make any ordinary product custom by simply adding the label. Roll Labels are easy to use and save on storage and easily peeled off and applied to your product. Gold Image Printing offers a variety of choices and options with paper and material for the right fit with your product.


Cruising the Norwegian fjords all year around.
Norway has passed the Caribbian as a tourist destination for the Brits and many other groups of tourists want to visit the fjords all year around. The Norwegian cruise industry is now meeting the demand.
Wenche Elisabeth Eeg from Cruise Norway stated to NRK this month that cruise ships will now sail in every month of the year. She indicates that the main reason for the new routes is the Northern Lights, which have been a successful form of marketing among potential travellers.
To read more, please visit The Norway Post.


I hope you enjoyed the summer break and are looking forward to a productive and enriching school year. As you are aware, this is the inaugural year for the Floyd Academy. I would like to first congratulate you and your child on his/her acceptance into the program. Participation in the Floyd Academy is a privilege, and, due to overwhelming interest and limited capacity, we have a list of students waiting to for acceptance. The program was designed to help your child succeed, and we look forward to your input and cooperation as we progress. The district and community have shown overwhelming support for this program, and we need your assistance to ensure that it is successful.
Orientation for all Floyd Academy students will be held on Thursday, September 1, 2016, from 12-4:30 pm. Attendance is mandatory. Student attendance at this orientation session is an indicator of their eagerness to become a member of the Floyd Academy and expresses a clear dedication to work toward graduation. The orientation will begin with lunch in the cafeteria (room 216), followed by a presentation. After the presentation, students will follow a truncated schedule to meet their teachers.
Transportation will be provided; please report to your bus stop 30-45 minutes before the start of school (approximately 11:15 am).
I am excited about the opportunity to work with you and the students to achieve their goals. I know that, working together, we will ensure the success of Floyd Academy students. On behalf of the Floyd Academy family, I would like to thank you for your continued support. We look forward to seeing your child on September 1.


text:
http://havanajournal.com/politics/entry/gao-reviewing-37million-annual-budget-and-effectiveness-of-radio-tv-marti/
HavanaJournal.com: Cuba Politics
GAO reviewing $37million annual budget and effectiveness of Radio TV Marti
Posted June 18, 2009 by publisher in Cuba Politics.
By Dan Robinson | Voice of America
U.S. lawmakers have heard testimony about continuing weaknesses in US government funded television broadcasting to Cuba. The Government Accountability Office (GAO) updated members of Congress on steps taken by the Broadcasting Board of Governors and its Office of Cuba Broadcasting on recommendations to deal with management, morale and other problems.
Since its inception in 1990, TV Marti has been the subject of controversy over cost, contracting, internal management and journalistic issues, and the inability of the Miami-based station to reach enough of the population in Cuba to justify the $500 million spent on the operation so far.
The Office of Cuba Broadcasting which runs TV and Radio Marti manages a staff of 153, producing 330 hours of Spanish language broadcasts each week to Cuba, costing nearly $37 million annually.
Radio and TV Marti Critics
While TV and Radio Marti have received praised for broadcasting news to people in Cuba, where the government jams foreign signals, TV Marti continues to face internal and external criticism.
Critics continue to question why TV Marti's audience by most accounts has remained small. The station has been the subject of GAO and State Department investigations into mismanagement and allegations of fraud and abuse.
"I wanted to focus on what seems to me to be a most egregious waste of money. TV Marti does not seem to have an audience. It's a station that no one watches. So why spend all the money on it?," said Massachusetts Democrat William Delahunt, who heads the House Subcommittee on International Organizations, Human Rights and Oversight Subcommittee.
TV Marti transmits over-the-air signals from an aircraft, the Aero Marti, two satellites, and the Internet to get programming into Cuba.
Limited Audience for TV and Radio Marti
Jess Ford of the Government Accountability Office (GAO), said that despite using multiple methods, the station's audience remains small based on four telephone surveys conducted since 2003. "The four telephone surveys have reported less than one percent of the respondents had watched TV Marti over the past week. Most notably, the most recent surveys in 2006 and 2008 showed no increase in reported TV Marti viewership after the launch of the Aero Marti and Direct Broadcasting," he said.
GAO mentions one non-random survey showing that 21 percent of recent Cuban émigrés listened to TV Marti within six months before leaving Cuba, but GAO says these results likely do not represent the actual size of TV Martí's audience.
A lack of access to Cuba, says GAO, has made it difficult to obtain nationally representative data on audience size, and decision-makers have had limited information to assess the relative success or return on investment for each transmission method.
Mismanagement and Lack of Effectiveness
While critical of mismanagement and other problems uncovered at TV Marti, California Republican Dana Rohrabacher says scrapping the station would be a mistake. "I think instead of focusing on scrapping radio or TV Marti, we should be focused on how to scrap the Communist dictatorship that [has] oppressed the Cuban people for these past 50 years," he said.
John Nichols, a comparative media expert and Professor of Communications and International Affairs at Penn State University reiterated his longstanding criticisms of TV Marti, saying it has failed to build an audience.
"TV Marti's response to a succession of failures over a two decade period has been to resort to ever more expensive technological gimmicks, all richly funded by Congress, and none of those gimmicks, such as the airplane have worked or probably can work without the compliance of the Cuban government. In short TV Marti is a highly wasteful and ineffective operation," he said.
Philip Peters, Vice President of Lexington Institute, a private research orgnization based in Virginia, disagrees with members of Congress who assert that ending TV Marti broadcasts would strengthen the Castro regime in Cuba: "I don't know how we have gotten ourselves in the position where this particular instrument of public diplomacy is a test of everyone's manhood with regard to Communism in Cuba. It's a tactic, it's not an end in itself, and I think that the only thing TV Marti has challenged is that Congress truly cares about the taxpayer money," he said.
In its overview, GAO said the Office of Cuba Broadcasting lacks a formal strategic plan to guide decision-making on its funding and operations, including a proposal to reduce TV Martí newscasts from two 30 minute evening programs to five minute news updates every half hour.
It also identified weaknesses in program review processes that broadcast managers use to assess compliance with journalistic standards, including accuracy, balance, and objectivity, and a lack of training for OCB staff.
While not commenting on specifics from Wednesday's hearing, Broadcasting Board of Governors Public Relations Chief Letitia King said the Broadcasting Board of Governors was in general agreement with GAO recommendations and has worked very closely with management of the Office of Cuba Broadcasting, and has a series of actions underway to address them.
On June 18, 2009, publisher wrote:
What a freaking waste of money.
And you wonder why the Embargo has been going on for so long? Because the Cuban American community gets MILLIONS AND MILLIONS of dollars every year to "fight" against Fidel Castro.
As much as Radio and TV Marti would like to see Fidel and Raul out of the picture, secretly they probably wish them long lives since they would loose their $37million dollars per year if they are out of power.
Am I wrong?
On June 18, 2009, pipefitter wrote:
No Pub, I think you hit the nail directly on the head this time.
Glad you agree. I am against propaganda from either extreme
As you know, I HATE propaganda.
On June 19, 2009, Yeyo wrote:
I completely agree. It is a total waste of money. The fact is that nobody watches TV Marti and very few listen to Radio Marti. No effect whatsoever on the Castros, I guess it plays the same effect that the embargo, giving them more ammunition to continue squeezing the Cuban people.


text:
Q: Custom filter in the sales order admin grid giving Invalid block t I've been able to filter custom added column  like 'seller name ' its get from seller id of product.
other filters are working.
$this->addColumn('seller_id', array(
        'header' => Mage::helper('marketplace')->__('Seller Names'),
        'index' => 'seller_id',
        'filter'    => true,
        'sortable'  => true,
       // 'renderer'  => 'marketplace/adminhtml_productrequest_renderer_sellername'
    ));

when I try to use the column to search I get an error like this.

exception 'Mage_Core_Exception' with message 'Invalid block type: 1' in C:\wamp\www\magento\app\Mage.php:595
      Stack trace:
       C:\wamp\www\magento\app\code\core\Mage\Core\Model\Layout.php(495):
  Mage::throwException('Invalid block t...')
      1 C:\wamp\www\magento\app\code\core\Mage\Core\Model\Layout.php(437):
  Mage_Core_Model_Layout->_getBlockInstance(true, Array)
      2 C:\wamp\www\magento\app\code\core\Mage\Adminhtml\Block\Widget\Grid\Column.php(369):
  Mage_Core_Model_Layout->createBlock(true)
      3 C:\wamp\www\magento\app\code\core\Mage\Adminhtml\Block\Widget\Grid\Column.php(51):
  Mage_Adminhtml_Block_Widget_Grid_Column->getFilter()
      4 C:\wamp\www\magento\app\code\core\Mage\Adminhtml\Block\Widget\Grid.php(314):
  Mage_Adminhtml_Block_Widget_Grid_Column->setGrid(Object(Mage_Adminhtml_Block_Sales_Order_Create_Search_Grid))
      5 C:\wamp\www\magento\app\code\local\Mage\Adminhtml\Block\Sales\Order\Create\Search\Grid.php(157):
  Mage_Adminhtml_Block_Widget_Grid->addColumn('seller_id', Array)
      6 C:\wamp\www\magento\app\code\core\Mage\Adminhtml\Block\Widget\Grid.php(624):

A: Suppose,your Marketplace module name is Abc_Marketplace.
As per as magento,there should be a class exit in your module
Abc_Marketplace_Block_Adminhtml_Productrequest_Renderer_Sellername
Which may be does not exit in your system that reason it show error.
May class name is wrong or may path location is wrong.for those reason you got error.
As per your comment,your block type prefix is mp.

<blocks>
      <mp><!-- this called as block type prefix  for Abc_Markeplace module -->
          <class>Abc_Marketplace_Block</class>
      </mp>
      ...
    </blocks>

So render class  block type is
'renderer'  => 'mp/adminhtml_productrequest_renderer_sellername'


text:
Q: Трудности при выборе фреймворка для JS-разработчика для создания мобильного приложения Давно смотрю в эту сторону.
Делаю обзор технологий и примеры ЛУЧШИХ фреймворков:

*

*PWA (SW),

*ВЕБВЬЮ (IONIC 4.0),

*ТРАНСПИЛИРУЕМЫЕ В НАТИВ (RN, NATIVESCRIPT, flutter, kivy, kotlin),

*НАТИВ (SWIFT, java).
Для фронтендера на JS есть:
React Native, Ionic, NativeScrpit.
И так, от теории к действиям.
ТРЕБОВАНИЯ К ПРИЛОЖЕНИЮ:
1) Работник открывает приложение утром и запускает геолокацию (геофенсинг);
2) Приложение на фоне следит за его перемещениями;
3) В конце дня работник вырубает приложение и идет домой.
Требования к платформе: пока только Android (но не суть);
Нашел готовое решение на IONIC:
https://ionicframework.com/docs/native/background-geolocation/
И вроде бы хорошо, Я ЗНАЮ VUE JS и могу внедрить в него его, а тем более, недавно вышла новая версия и + завезли свой  STENCIL, т.е. можно обойтись и без apache CORDOVA (не имел опыта с ним, но он имеет негативные отзывы в сети - по перфомансу в частности).
НО!!! Огорчает тот факт, что это как был webView, так им и остается.
Не видел нормальных приложений от фронтендеров как я (крупные конторы могут себе позволить писать на нативе и им не особо доверяю, по причине того, что много вставок делают на нативе).
Есть еще NativeScript-vue, который идеально подходит, по скорости моей разработки на нем (даже онлайн конструктор запилили + результат сразу на мобилке,  за 5 мин, без установки ПО на комп),  но огорчает, что работа геолокации в фоне - под большим вопросом + не популярный. Знаю, что во всех этих фреймворках есть тема фоновые задачи, но вот вопрос к советчикам - кто их применял на практике в связке с геолокацией?....
А ReactNative - самый популярный - это понятно, это реакт, который я не знаю, но тоже нет гарантии, что в фоне нормально работать будет (и, как говорил выше, крупные разработчики делают много вставок на нативе, которые я не могу себе пока позволить).
Последнюю неделю стал смотреть в сторону DART FLUTTER, говорят, что он лучше всех из этого списка справится с поставленной задачей. А кто-то писал, что надо будет еще натив писать (чтобы в фоне работало).
И эти все неоднозначности меня отпугивают приняться за изучение чего-то одного...

*

*Хочется еще сразу на будущее, чтобы за границей катировалось, но только react катируется, который я так упорно игнорю (т.к. это конкурент VUE).

Ах, да, есть же еще PWA (service workers), но с 2016 года туда так и ни один браузер не завез geofencing, а жаль..

A: Попробуй почитать подробнее про эту библиотеку для Flutter, она предоставляет возможности фоновой геолокации
Так же у них есть демо приложение в Google Play

A: за основу можно взять React Native а именно react native init т.к. в нем можно в дальнейшем использовать нативные модули хорошее сравнение init и expo есть на хабре


This post is sponsored by Nakturnal. All thoughts and opinions are my own.
Obviously I am taking a quick break from the Nebraska Counties series that I have been writing. Since the topic is keeping kids safe, I feel like it is a worthwhile departure.
A few weeks ago, our "baby" turned 8. While there is a certain freedom in having older kids, this means that much has changed over my past 14 years of parenting. While I can always get my kids to give me a hug, the cuddling and imaginative play are slowly coming to an end. Thankfully three years ago, I got a new title.
Now I have two of the cutest nieces and two of the most adorable nephews. Since our kids are older, I feel like I can enjoy this stage more than I sometimes did when I was in the midst of my own chaos that toddlers can bring. All of the snuggling without the sleepless nights. Kind of like a prelude to grandparenting, but I definitely do not feel old enough for that stage!
When the munchkins come over to visit, one thing is quite apparent: our house is no longer baby proof. After all, my kids are able to safely walk up and down the stairs, not generally put things into their mouths that aren't food (although I have seen a lego or two go there 🙁 ), and if they are still wanting to put things in light sockets, we have other issues to deal with. Thankfully I have a strong crew of four who help me keep the littles occupied, so I am generally not too worried when the nieces and nephews visit. When we had four kids that were six and under, I was petrified at all of the dangers my house seemed to present.
If you have little ones in your life and have not been to this site, go there NOW. (Actually read the rest of this post first … 🙂 ) Far more than diapers, you can find all of the baby stuff that you could possibly need without having to bundle up kids and take them to the store with you. Shipping is even free if you spend more than $50. Goodness knows that is not hard to do when it comes to all of the paraphernalia that babies need. Back to the safety part.
Finding outlet plugs and cabinet latches was not challenging. Finding a baby gate was. You see, we live in a house that has four half flights of stairs. Lots of possibilities for my kids to crash and burn. (Considering the fact that my oldest tumbled down several stairs as a toddler when we were touring a house to buy, I did not want to see or hear that horrible sound of thudding EVER again!) My parents have had a baby gate at the top of the stairs for pretty much most of the past 14 years, since their kids started having kids. (Yeah, they are gracious like that). But theirs is the type that unhooks. Most of the time, I just try to climb over it and hope that I do not tumble down the stairs myself. I knew that I wanted something different for our house because climbing over a stair gate with a baby is NEVER recommended.
After much searching and hunting online, we finally found an easy close latch gate. (Between that and the door at the top of one set of stairs, I mainly felt like our kids were safe. But I did breath a sigh of relief once they all could walk up and down on their own!) That baby gate that took us about a week to find? Yeah, well, the site I would have assumed just sold diapers has at least 100 of the very type we were looking for, in various colors. (They also have the lattice latch crowbar type ones if you are able to maneuver over with more grace than I ever could.) If they have all of these baby gate options, imagine what else they have.
I am happy to announce that I have been provided with a $50 gift card toward an online baby shopping spree at this great site for one of my readers. Winning is simple. Please comment below on one of the best ways that you have found to keep your babies safe OR one of the baby products that you are unable to live without. Besides the gate, I could not have survived the early years without the baby swing that could go both forwards and backwards as well as side to side. This contest will end the end of next week. Right in time for Thanksgiving. $50 toward baby/childhood gear is something to be thankful for, but knowing that your children are safe at home is even better!
Considering the fact that my friend rode home from the hospital on his four year old sister's lap, childhood safety has come a LONG way. I really like this perspective by Her View from Home writer, Kara Stevens, on the fact that it is okay to keep up with the times when it comes to safety.
We love baby gates for keeping our little ones safe!
all of our stairs have doors so we keep them shut at all times. other than doors i could t live with out the door knob things so little's can open the doors by themselves!!!
We loved the rock n play this time around!
We loved our Moby wrap and Rockin Play!!!!
I couldn't have made it through the first six months without a baby swing like the one you describe – back and forth and side to side. Our baby often slept in it, especially when she was sick and couldn't breathe laying flat. We also have a pass-through baby gate that has been a life-saver. We don't have stairs to worry about, but the gate made it possible to have one room in the house that was completely baby-proof. I could put a load in the laundry or go to the bathroom without worrying about whether she was safe.
I could not go without baby gates. I am a huge worrier and baby gates helped me worry just a little less.


In this series of Prolific+ articles, we highlight five Northern startups at the cutting edge of digital healthcare, and focus in on one Salford-based company that's already providing remote access to consultations and free prescription drug delivery for 15 million people. We also meet three other interesting health and wellbeing companies in the region: fitness company Orangetheory, "wearable for the mind" Moodbeam and Yorkshire-based subscription service Vegan Tuck Box.
Piers Morgan may deride it as an "increasingly irritating" concept, but veganism is indisputedly having its moment.
According to the chief executive of Health Innovation Manchester, HealthTech "allows commissioners, providers and consumers alike to derive benefits".
Demand is growing for the digitisation of the UK's healthcare sector and the NHS is set to become more modern, user-friendly and cost-effective - if only it chooses to collaborate with the telehealth providers out there.
It's America's fastest growing studio gym franchise - and now Orangetheory Fitness is hoping its wearable tech workouts will catch on just as quickly in the UK.
In what can only be a positive move, more people are discussing mental health than ever before. In professional and personal spheres, it has become a high-profile topic of conversation.


text:
Sony / Zeiss FE Distagon T* 35mm f/1.4 ZA ( SEL35F14Z ) - Review / Test Report
Lens Reviews - Sony Alpha (Full Format)
It seems as if the Zeiss-Sony relationship has cooled off a little lately- probably because both want to harvest the premium segment. Zeiss appears to gravitate towards their own Zeiss Batis lens lineup now whereas Sony is focusing on Sony G and GM lenses. However, a while ago, the Sony / Zeiss Distagon T* FE 35mm f/1.4 ZA was one of the first high-speed, pro-grade lenses released for Sony's full format mirrorless system. As you may have guessed already, such a lens isn't cheap at around 1500USD/EUR. However, and this may come as a shock to some, it is a little more affordable than similar offerings from Canon and Nikon. Feels almost like a Sony first in this respect ...
In the Zeiss world, the word "Distagon" relates to a wide-angle lens - derived from DISTAnce (large distance to the subject) and the Greek word GONia (angle). Distagons are so-called retro-focus (inverted tele-) lenses. Traditionally such lenses allow a bigger distance from the rear element to the sensor (required for DSLRs) but this is not the case here.
The build quality of the Zeiss lens is superb. It's a tightly assembled, all-metal construction. A rarely found feature in the Sony lineup is the dedicated aperture ring. Interestingly there's a dedicated switch for choosing between "clicked" or smooth aperture changes. Movie makers will surely appreciate the option here. The focus ring operates silky smooth.
Mirrorless systems are often advertised towards smaller size and lower weight. This isn't really true here (nor for most other Sony FE lenses actually). Compared to e.g. the Canon EF 35mm f/1.4 USM L II (DSLR lens), the Sony/Zeiss is just marginally more light-weight but it's actually a bit longer.
Sony uses its Direct Drive Super Sonic Wave Motor (DDSSM) for auto-focusing. The AF speed is Okayish (on the A7R II) and AF operations are noiseless. The focus accuracy is very high. As usual, manual focusing works by-wire. For precision focusing this is a good thing but it feels different compared to a mechanically coupled focusing mechanism.
Optical construction 12 elements in 8 groups inc. 1x advanced aspherical & 2x aspherical elements
min. focus distance 0.3m (1:5.5)
Dimensions 78.5x112.0mm
Hood supplied, petal-style, bayonet mount
Other features dust- and moisture-resistant, aperture ring


Next week a bunch of professionals will take the saying "see you in the ring" literally, as they compete for a fight title. The first title in 2019 will be up for grabs in the Legion 9 Fightsports. More than 20 fighters will take part in 11 different events. The event has attracted fighters from interstate and around Tasmania. Trainer and part promoter Jacob Gelston said the event focuses on Muay Thai and mixed material arts through separate events. "The Muay Thai is like kick boxing with knees and elbows. So if you get swept over you get stood back, they keep fighting," Gelston said. "But with MMA there is another issue where there is wrestling and jujitsu on the ground. So if you go to the ground you can be submitted. But in Muay Thai you get stood back up." Competitors will focus on striking in Muay Thai, but with MMA there is a "huge grappling" event, Gelston said. "There are different classes due to their level of experience … and obviously we have amateur and professional levels, too," he said. Two Launceston locals will compete for the titles. Damon Upton-Greer will take part in the Legion Muay Thai Super Middleweight Title. He will compete against Chris Drummond. "Damon Upton-Greer has won an MMA title through Legion and is now fighting for a Muay Thai title. So he is aiming to be the first person to have a title in both disciplines in Tassie and for Legion," Gelston said. "The other person fighting for a title is Casey Lockett which is young local and has got a lot of potential and skill as well. So he is fighting a guy from Hobart called Stu Dare." Lockett is competing in the Legion Muay Thai Cruiserweight Title. "That will be a really good fight as well," Gelston said. Fighters will fly in from Victoria and NSW to help match the cards, and from around the state as well The Legion Muay Thai Heavyweight Title Eliminator will be between Pat Dittrich and Joe Tullo. Gelston said other states typically have separate MMA and Muay Thai events. "Due to Tasmania's size we have different bouts at the one show due to the size of the state and what we can offer." More than 800 people are expected to pack the Elphin Sports Centre to watch the events. Court side seats have already sold out. "They'll see plenty of action having both MMA and Muay Thai fights. The titles are both being fought by local guys. It's a good atmosphere," Gelston said. "You can be looking at the ball and someone jumps on the back of you head with his knee and you don't even see it coming." Organisers also try to make the events family-friendly and encourage people to bring their kids and whole family along. The fighters spend many hours each week preparing for each event and dedicate themselves to doing their best. "It depends on who they are and what they are, but for our guys they're doing four to five Muay Thai sessions a week and three to four runs, and probably a couple of strength and conditioning classes," Gelston said. "I often say to people in their fight camps, people put in 70, 80, 90 hours of training for six minutes in the ring." The training also includes recovery massage and rehabilitation. "That's because when you're training that intensely you do tweak things and it's hard to run at 100 per cent all the time," Gelston said. "It's a big commitment. So that's why people will often have just one or two fights and then they've achieved what they wanted to to say they could do it because then they realise how hard it is to keep going to do fight camp after fight camp. It is very grueling." But Gelston said the risk of injury is a lot lower that some other sports, with the more skill you have lowering the risk of injury further. "When you fight professionally you fight with elbows and only gloves, but also your skill level reduces the risk," he said. "When you're starting up we have what's called C Class where you fight in shin pads and bigger gloves and the opportunity to fight in head gear as well." While he acknowledges there is always a risk, it's lower than football, for example. "For me personally, I played sport for a lot of years and I was constantly injuring myself playing football, the risk is a lot higher in a lot of respects in football," he said. "You can be looking at the ball and someone jumps on the back of you head with his knee and you don't even see it coming." The Fights happens in a controlled environment with a referee. "You're always looking at your opponent and if you're in trouble the ref stops the fight," Gelston said. "There is injury and risk in everything that you do but we're all about reducing risk and I think it's got a bad reputation, but it's not what it is." Tickets to the event can be purchased from legionfightsports.com.au. The event will happen on February 16 from 6pm.
Legion promoter and trainer Jacob Gelston.
Next week a bunch of professionals will take the saying "see you in the ring" literally, as they compete for a fight title.
The first title in 2019 will be up for grabs in the Legion 9 Fightsports.
More than 20 fighters will take part in 11 different events.
The event has attracted fighters from interstate and around Tasmania.
Trainer and part promoter Jacob Gelston said the event focuses on Muay Thai and mixed material arts through separate events.
"The Muay Thai is like kick boxing with knees and elbows. So if you get swept over you get stood back, they keep fighting," Gelston said.
Competitors will focus on striking in Muay Thai, but with MMA there is a "huge grappling" event, Gelston said.
"There are different classes due to their level of experience … and obviously we have amateur and professional levels, too," he said.
Two Launceston locals will compete for the titles.
Damon Upton-Greer will take part in the Legion Muay Thai Super Middleweight Title.
He will compete against Chris Drummond.
"Damon Upton-Greer has won an MMA title through Legion and is now fighting for a Muay Thai title. So he is aiming to be the first person to have a title in both disciplines in Tassie and for Legion," Gelston said.
Lockett is competing in the Legion Muay Thai Cruiserweight Title.
"That will be a really good fight as well," Gelston said.
The Legion Muay Thai Heavyweight Title Eliminator will be between Pat Dittrich and Joe Tullo.
Gelston said other states typically have separate MMA and Muay Thai events.
More than 800 people are expected to pack the Elphin Sports Centre to watch the events. Court side seats have already sold out.
"They'll see plenty of action having both MMA and Muay Thai fights. The titles are both being fought by local guys. It's a good atmosphere," Gelston said.
Organisers also try to make the events family-friendly and encourage people to bring their kids and whole family along.
The fighters spend many hours each week preparing for each event and dedicate themselves to doing their best.
"It depends on who they are and what they are, but for our guys they're doing four to five Muay Thai sessions a week and three to four runs, and probably a couple of strength and conditioning classes," Gelston said.
The training also includes recovery massage and rehabilitation.
"That's because when you're training that intensely you do tweak things and it's hard to run at 100 per cent all the time," Gelston said.
But Gelston said the risk of injury is a lot lower that some other sports, with the more skill you have lowering the risk of injury further.
"When you fight professionally you fight with elbows and only gloves, but also your skill level reduces the risk," he said.
While he acknowledges there is always a risk, it's lower than football, for example.
"For me personally, I played sport for a lot of years and I was constantly injuring myself playing football, the risk is a lot higher in a lot of respects in football," he said.
The Fights happens in a controlled environment with a referee.
"You're always looking at your opponent and if you're in trouble the ref stops the fight," Gelston said.
Tickets to the event can be purchased from legionfightsports.com.au.
The event will happen on February 16 from 6pm.


A visual slideshow of images from a recent Cocorosie tour.
Bianca Casady, Bunny Rabbit, Sierra Casady, Militia Shimkovitz, and Lil Rae Rae - Part of the Voodoo Eros gang in Brooklyn, early 2007.
Bianca Casady at Karaoke, New York.
Sierra and Bianca, Miami concert at the Raleigh Hotel during Miami Art Basel.
Bianca and Sierra after the show at Olympia.


text:
Elon Musk Is Already Grinding Us Down
He doesn't know what he's talking about. But you don't have to be the one to educate him.
There's a line from the tech analyst Benedict Evans that has been making the rounds recently. Evans says that Elon Musk is "a bullshitter who delivers." It's a good line because it is (1) true enough, and (2) that contradiction is what makes lots of people pay attention to Elon's every move. This, of course, means that people are also paying attention to a lot of bullshit. Evans's axiom isn't foolproof. Musk is a bullshitter who also sometimes simply bullshits. There are full websites dedicated to Musk's broken promises. The man not only changes his mind quite frequently but is also prone to acting out—in part because it garners a lot of attention but also because, as Bloomberg's Matt Levine put it recently, he "infuriatingly refuses to comply with the basic expectations of law and society" and he "is too impetuous and doesn't really believe in rules or social norms."
And so, Musk has been tweeting quite a bit about his new company ever since Twitter approved his offer on Monday. The tweets have mostly been, well, shitty. He's twice called out Twitter's top lawyer, Vijaya Gadde, suggesting that Twitter's content-moderation decisions have a left-wing bias. (The tweets led to a predictable pile on directed at Gadde and all kinds of racist language and threats; Musk feigned ignorance about the harassment when Twitter's former CEO called him on it.) His vitriol has led to about a dozen Twitter employees being harassed. He's been doing a lot of replying to right-wing/anti-SJW/MAGA or MAGA-adjacent Twitter pundits like Dave Rubin, Mike Cernovich, and Ben Shapiro, signaling agreement with their "the left is unhinged" speech critiques.
A theme of Musk's recent tweets has been restoring Twitter to a kind of political neutrality, one he argues will anger the right and the left equally. So far he doesn't seem to have signaled any ways that his tenure might frustrate the right flank. On Thursday, Musk tweeted a meme that suggests that the left has shifted dramatically further left since 2008 while the right has more or less stayed the same, leading centrists to identify more closely with the right. The tweets attacking Twitter staff sound, as Casey Newton remarked, "less like Twitter's future leader and more like a special counsel appointed by House Republicans to identify Bias in The Algorithm."
Musk's tweets reflect bad leadership and shitty behavior. But they also reveal a shallow understanding of speech principles and a wrongheaded or at least obtuse analysis of our current politics. That meme chart? It is, as dozens have pointed out, wrong, and the reality is certainly far more complicated. Similarly facile is Musk's notion that Twitter's free speech will comply with U.S. law, nothing more or less. In that case, Musk should be ready for Twitter to host virtual child-pornography videos (acceptable, via Supreme Court ruling) and all kinds of spam (which he purports to want to remove). Content moderation and speech laws: Combined, they're a mess … and not often how they seem!
Watching this saga play out over Twitter, where each hastily composed Muskism is met with long, detailed debunks from people who mean well and know better, but who should probably also know better, has been frustrating. Researcher Renée DiResta captured the dynamic perfectly.
lots of "bringing stats to a meme fight" happening on here today
— Renee DiResta (@noUpside) April 28, 2022
It is both heartening and disappointing to watch lawyers, political scientists, historians, and experts in fields like content moderation and First Amendment law battle Musk's missives in the replies. The spectacle represents the best and worst of Twitter, the platform. On one hand, you have people publicly putting their various esoteric bits of deep knowledge to use; if you follow enough threads and have the ability to identify the people with trustworthy credentials, there's a good chance you'll learn quite a bit about moderation, speech law, and mergers and acquisitions, and even something about political-polarization trends. On the other hand, you have a very wealthy boob speculating and bloviating with extreme confidence and attracting enough attention to force others to parachute in and mop up his rhetorical messes.
Well, if a cartoon on the internet says so, it must be tru-- wait, what's this?https://t.co/63J3t3iekH
— Kevin M. Kruse (@KevinMKruse) April 28, 2022
I understand why people are putting a lot of time and energy into bringing their stats to the meme fight. Elon has a great deal of money and power and a large audience that hangs on his words. When he says something dumb or wrong, it makes sense to want to correct the record. For an academic or journalist or servant of the law, it very well might be the proper thing to do. But for a denizen of Twitter dot com, it is a mostly fruitless endeavor, and one that gives Musk what he wants—proof of outrage.
Note that since the purchase, Musk only seems to reply to those already in agreement with him—in this case, people who believe that Twitter's speech is heavily biased toward the left, or that liberals on Twitter seem to be freaking out way too much over his potential acquisition. So far, I haven't seen him respond to the tweets from journalists and academics asking him to clarify his points or offering evidence that contradicts his claims. Given that it's clear he's reading at least the verified portions of his mentions, it's safe to assume he's not very interested in engaging with those arguments. Maybe that's because his mind is made up for now. And so we get the memes, which are reductive. But that's the point! The meme—unlike the nuanced, information-laden tweetstorm rebuttals—is immediately legible to a wider audience, and also more engaging. By the time the claim is debunked, Musk and his fans have moved on, but the meme has created enough backlash that Musk can point to it and go, "See?! They're going nuts … over a meme! They've lost it!"
We went through this with Donald Trump. (Though Musk knows how to use a computer, so unsurprisingly he engages in a more responsive, shitposty way.) Trump's tweets not only enraged legions, prompting a backlash that Trump and MAGA influencers would then use to rile up their bases, they also created their own little (mis)information economy. Both Trump haters and lovers would race to be among the first people to reply to one of his tweets in the hopes that Twitter's weighted reply algorithm would put them in the valuable engagement real estate directly below his original message. Scammers, pundits, trolls, and even media companies tried to surf the Trump wave of engagement for a little amplification, which meant, of course, directing attention at Trump himself. There is an enticing but very slim upside to engaging with an attentional black hole like Trump or Musk on Twitter. You probably won't get what you want, but they will.


Senior Resident – Post Graduate Degree/Diploma from a recognized university or equivalent as per MCI.
Junior Resident – Graduate from a recognized university with registered Delhi Municipal Council.
Eligible & Interested candidates can download notification in Official website page in www.mcdonline.gov.in NDMC Recruitment Walk-in Interview 2017.
Eligible Candidates advised to Download and read NDMC Job notification to get aware of recruitment schedule and venue from the official website.


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Outside Sales Definition | Marketing Dictionary | MBA Skool-Study.Learn.Share.
Outside sales are the sales that are carried out by the employees of the company or the salesperson away from the premises of the company. it can be at the clients place or it can be a salesman going door to door.
Sometimes the inside sales department helps the outside sales people to book their appointment with the clients.
The salesperson which goes door to door.
Browse the definition and meaning of more terms similar to Outside Sales. The Management Dictionary covers over 7000 business concepts from 6 categories.
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On July 9–14, The Lutheran Church–Missouri Synod met in convention in Milwaukee. As conventions go, I am more of one who endures them rather than looks forward to them. With that said I will say that this convention was probably the most productive and fruitful convention I have ever participated in. The topics of discussion and resolution were theological in nature and practical in application. There were 18 floor committees so that each committee could work with fewer resolutions allowing for more precise and accurate material. Over all I was very impressed by the presentations, floor discussions of the delegates, and general direction of the Synod on theological matters.
Conventions are divided into three categories. The three are elections, essayists, and resolutions. As far as elections were concerned, the entire presidium was re-elected. I have worked with these men for many years now and find them to be very qualified. They each possess great theological wisdom with compassionate hearts for Christ and His Gospel to be preached to the world. The new Secretary of Synod (Ray Hartwig is retiring) is John Sias from Montana. He is a skilled young man in theology and the handbook. I think he will fill this position very well.
The essayists all worked with the theme "Upon this Rock". The speakers were from inside and from outside of our Synod. One of them was a Roman Catholic who spoke about the social and political decay of our nation. He was very interesting and invoked the Church to stand on Christ the Rock on more than one occasion. Over all I was pleased with the essays and learned from them.
The resolutions of any convention are always interesting and at times can be a bit contentious. The tenor of the discussions was quite civil–even in the midst of contrary views. Emotions were kept in check for the most part as biblical theology oversaw the rational and reason for supporting or not supporting a particular resolution. The Office of the Ministry received a great deal of discussion and was overwhelmingly supported by the assembly. Divine Service, liturgy, preaching, hymnody, the Lord's Supper, and good order in the Church were discussed. Again, by large margins, the assembly voted for continuity, consistency, and confessional standards to govern the worship of Christ by His Church.
As optimistic as I am about the Synod in convention, it by no means indicates that our work is going to be any easier. If one message came through loud and clear it was that the society in which we live is no longer tolerant of Christianity. In fact, it is increasingly anti-Christian. Our only hope remains where it always has been. It is in Christ Jesus, the Solid Rock upon which we stand, that the wind and waves of persecution will not overcome us. The gates of hell will not and cannot prevail against Christ and His Church.
The direction and wisdom that came from this convention places us upon the ramparts of He who did everything necessary to secure our salvation. Just as His suffering and death was followed by the glorious resurrection, our lives are buried with Him in baptism only to be raised again to a new life that stands secure by faith in He who defeated sin, death, and the devil. As conventions of Synod go, I was blessed to have attended and participated. I pray the fruits of this labor will manifest faithfulness to God's Word and fidelity to the Lutheran Confessions. Therein is our hope and stay. Upon this Rock we shall stand. Upon this Rock we are secure unto eternal life.


text:
Q: How to make parts of a sprite transparent? I posted the following question at www.reddit.com/r/kivy but nobody could help me.
Let's say I have a red square and I want a hole in it so that the background can be seen through this hole. It ought to be possible to do that but I can't find a way. I found the following snippet but it doesn't work. Is that because it simply couldn't work or because I'm trying to make it work on a Samsung Galaxy Tab 3? I hope someone can enlighten me, thank you in advance.
from PIL import Image

img = Image.open('img.jpg')
img = img.convert("RGBA")
datas = img.getdata()

newData = []
for item in datas:
    if item[0] == 255 and item[1] == 255 and item[2] == 255:
        newData.append((255, 255, 255, 0))
    else:
        newData.append(item)

img.putdata(newData)
img.save("img2.jpg")

With C++ and DirectX there is no problem, one can set a certain colour to be transparent, t.ex white, so that all white pixels in a sprite are not drawn.
The same must be possible for Kivy, but I can't make it work.
I hope someone can explain how it is done. Thanks.

A: The jpg format does not support transparency.  You should use a format that does, like png.

A: I have finally found a way to make a part of a sprite transparent.
I can't say I understand what's going on, but if the image is a GIF (not a PNG), one can use GIMP (the free drawing program).
Add an alpha channel, delete the part that should be transparent and export the file as a GIF. Then it works.
PNG-files ought to work too but doesn't (at least for me). Maybe it's because I use QPython on my tablet to run Kivy-files.


We'll use oil paint with cold wax on oil papers for exciting results. You'll learn how using mark-making, textures, color and design to create intriguing works with this medium. We'll also use oil stick, pens, solvents, texture tools and lots more on special papers.


text:
Mark Twain Can't Remember Recent Things But Vividly Recalls His Hannibal Courier Co-Workers
Mark Twain (Samuel Clemens) declares that "recent names & things take no hold" on his "bald-headed memory; they slip-up & slide off" so he isn't sure about Mrs. Brackett - but to the mention of names and things from thirty-five years ago, his memory is alert. Virginia City is a blur: he made such an innumerable host of acquaintances, he cannot name twenty from then with certainty. But the associates of his youth in Hannibal he recalls vividly; new acquaintances there averaged only about one a year, causing less wear & tear to the memory. He pleasantly remembers the printer Urban Hicks, and his young Hannibal Courier co-workers Pet McMurry & Wales McCormick, too:
& also the fencing-matches with column rules & quack medicine stereotypes; & lots of other things which would be rubbish in another man's mind, maybe, but I don't consider them so.
He saw Pet McMurry & Wales McCormick just the year before for the first time in 30 years – and if he could see Hicks in Hartford, he would "receive him with a barbecue & a torchlight procession." He inquires what Hicks has been doing all these years, and says he shakes him by the hand and wishes him luck. Clemens' adds that he is due to speak at a printer's dinner that very night, and thanks his correspondent for giving him a text.
Autograph Letter Signed ("S.L. Clemens"), 3 pages, octavo, Hartford, January 17, 1886. To "Dear Sir."
Hartford, Jan. 17/86.
I am not perfectly sure about Mrs. Brackett, for recent names & things take no hold on my bald-headed memory ; they slip-up & slide off : but when you come to the names & things of thirty-five years ago, you are uttering music, & my memory is alert. We led such a rushing life in Virginia City, & made such an innumerable host of acquaintances, that that existence is all a foggy confusion in my mind, & I cannot name twenty people of that day & district
with certainty ; but in Hannibal, thirty-five years ago, the new acquaintances averaged only about one a year, & that sort of contact didn't wear-&-tear the memory much. I remember Urban E. vividly & pleasantly ; & also the fencing-matches with column-rules & quack medicine stereotypes ; & lots of other things which would be rubbish in another man's mind, maybe, but I don't consider them so.
I saw Pet McMurry & Wales McCormick a year ago, for the first time in 30 years ; & now if I could see
Hicks here I would receive him with a barbecue & a torchlight procession, & put the entire house at his disposal. I would like first-rate to know what he has been doing, all these years, & where tarrying. I shake him by the hand & wish him luck.
Truly Yours
S L CLEMENS
I am to talk at the printers' dinner in New York, & I thank you for a text.
Mark Twain's Autograph Notes Regarding People, Places, and Recalling an Incident


Anorexia athletica is a constellation of disordered behaviors on the eating disorder spectrum that is distinct from anorexia or bulimia. It is most commonly found in pre-professional and elite athletes, though it can exist in the general population as well. People with this condition connect self-worth is tied to physical performance and although some concern may be present about the size and shape of the body, more emphasis is placed on compared oneself to successful or professional counterparts.
You can read our main overview of anorexia athletica here, or scroll down to browse the latest content.
What Are The Treatments for Anorexia Athletica?


text:
Q: Issue - Two forms with the same CSS class name in casperjs I have two forms in the same page with the  same CSS class names .
<form class="formFormatClass" >
</form>
<form class="formFormatClass" >
</form>

when I'm filling form data using the below code snippet , it is always considering the first form but not the second form.
this.fill('form.formFormatClass', {
      donorNumber :  DONOR_NUMBER_VALUE,
      firstName :    'srikanth',
      lastName  :'',
      anyBloodGroup : 'true',
     dueToDonate : 'false' }, true);

How can I write code to fill in the second form without  making changes to the already designed JSP pages

A: As others suggested adding an id to each form will help distinguish them:
<form class="formFormatClass" id="form1">
</form>
<form class="formFormatClass" id="form2">
</form>

this.fill('#form1', {
      donorNumber :  DONOR_NUMBER_VALUE,
      firstName :    'srikanth',
      lastName  :'',
      anyBloodGroup : 'true',
     dueToDonate : 'false' }, true);

this.fill('#form2', { ...


text:
Home Features Columns By The Numbers
Q & A: David Acklin
Backtalk
79 — Episodes in Star Trek's original series
16.2 million — Average number of viewers during episodes of House in 2007-2008
6 — Number of awards or nominations Hugh Laurie (Dr. House) has racked up since the show began (2 Golden Globes, 1 Screen Actors Guild, and 3 Emmys)
1.3 — Gallons of blood in an average person's body
$2.2 trillion — Amount of money spent on health care in the U.S. in 2007
31 — Number of cities or towns in the U.S. with "liberty" in their name
5 — Number of places in the U.S. named "America"
4 — Number of U.S. presidents born in the month of July
1 — Number of presidents born on the 4th of July (Calvin Coolidge)
$206.3 million — Dollar value of fireworks imported to the United States from China
4 — Memphis Redbirds pitchers who have started the Triple-A All-Star Game
45.7 million — Number of people in the United States without health insurance
3 million — Number of new health-care jobs projected to be generated between 2006 and 2016
July-2009 Columns Memphis Magazine July 2009


Business process outsourcing (BPO) is a subset of outsourcing that involves the contracting of the operations and responsibilities of a specific business process, to a third-party service provider. Usually, BPO is implemented as a cost-saving measure for tasks that a company requires but does not depend upon to maintain their position in the marketplace. Often organizations intend to focus on their core functions leaving the support functions in the hands of experts providing outsourcing services. This way organizations can spend more time on developing the core functions and drive businesses growth.
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Developing business insights from KPI reports, etc.
Business organizations focus on business. Laps in legal and secretarial works at times lead to great challenges and penalties. We assist our clients in the following matters.
Company registration, Tax & VAT registration, commercial body memberships, etc.
One of the most challenging jobs is handling legal and regulatory compliance in each organization. We assist our clients with the following services.
Preparing employee files & validating documents, etc.