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An interview with Bruno Esrubilsky
by Paul Kim May 02, 2019
Bruno Esrubilsky is an Argentine born-Brazilian raised drummer who is currently on tour with the singer-songwriter Mitski. Bruno has already toured all around the world, played at prominent festivals such as Coachella, Bonnaroo, and Lollapalooza, and performed numerous times on television (Conan, Ellen, Kimmel etc.). He has accomplished quite a lot in his young career.
We took a moment to ask him some questions about his life to get to know him a little better.
Hi Bruno, please share your story with us and how you got started as a drummer. How did you get to where you are today?
I grew up in Rio de Janeiro, Brazil, and consider myself lucky to be from such a rich rhythmic place; but I truly picked up drumming after listening to Rush's Moving Pictures and Kiss' Creatures of the Night, those albums really spoke to me drum wise. In Rio I was lucky to have amazing teachers, most noticeably Pascoal Meirelles who was a big influence on me, pushing me to sight read a lot and focus on the touch and feel aspect of drumming.
He was also instrumental in me pursuing going to Berklee in Boston and that alone led to learning from some of the very best, Terri Lyne Carrington and Dave DiCenso being some of them. Moving to the States was huge for me, and it helped me quickly realize that playing lots of different music worked well for me, so it felt natural to pursue a career as a sideman drummer.
Learning lots of world music and hand percussion instruments was also fundamental in expanding my horizons and helping me feel comfortable in as many situations as possible. During my 20's I was playing anywhere from big band jazz, Flamenco, Brazilian music and pop/rock.
When I moved to NYC, I played every gig that came my way; it was tough for me to say no to anything. That helped me feel comfortable in so many situations: I was playing singer/songwriter gigs (with and without rehearsals…), off Broadway shows, Broadway shows (Hedwig and The Angry Inch), shows with dance groups, TV performances (Kimmel, Ellen, Conan, America's Got Talent, Today Show), and that has led to a lot of touring now.
Overall, how has the journey been? Has it been relatively smooth? If not, what were some of the struggles along the way?
Moving out of my country, especially to try a career in the arts felt like a gamble; I took it because I was set on playing drums for a living, and I truly believe that if you trust yourself and know that you love doing it, then there's a place for you. That being said, it's not an easy path to follow.
It takes building resilience, a thick skin, self confidence, learning to deal with rejection, lots of hopes and expectations. I try my best to go with the flow, trust the process and just work hard through the good and bad moments.
Being able to shut the inner voice that tells you you're following the wrong path isn't easy, but you can get good at it. I've found it helpful to mentally pat myself on the back at every small victory, whatever they may mean to me.
This lifestyle is built on small victories, knowing how to recognize them, and knowing that you'll also probably fail a lot - keeping in mind that failures are actually tiny lessons just waiting to be learned from. I now realize I lost gigs that I thought were going to lead me places, only to find that had I not lost them, I wouldn't have gotten even better gigs, with amazing people that I now call friends.
Mitski's "Be The Cowboy" has been acclaimed by numerous critics and music fans. How is the touring experience so far? What are some of the highlights of the tour so far?
Mitski is such an amazing artist and I am truly thankful to be a part of her world and to help make her creations come to life on stage. Her music covers so much ground, so each show feels like a musical workout, and I thrive on that.
The very first tour I did with her was supporting Lorde on an arena tour, and it was awesome. It was also good having to hustle it, sometimes play shows without even a line check, and be prepared to set up and break down gear in personal record time. Since then we've been touring for more than a year and it's been phenomenal. She is a true performer, and I try to match her energy every night, to help her do her thing.
She can also play a bunch of instruments and played bass in the first couple of tours. Now she added amazing choreography, and I keep my eyes on her basically the whole show, watching for cues and little movements that may give me a hint of where things are going.
So many highlights so far, we've played amazing shows in 2018, performed on Jimmy Kimmel, played sold out Europe and North America tours including 4 nights at Brooklyn Steel, which is home for me. I'm quite lucky.
What is a typical warm up / practice routine that you do on a regular basis, and what is a routine that you would recommend to a drummer?
Nowadays when I get time alone in my practice space, I enjoy playing to music that is different from what I play on tour. I may go back to playing some jazz, Brazilian music, world music styles, trying to get my brain flowing a bit differently than on tour.
Also, a book I always seem to go back to since I started playing is New Breed by Gary Chester. It's such a good book to get the limbs moving and have you thinking about different patterns and possibilities. On tour, my warm up before a show usually consists of jumping rope for a few minutes, doing a few running drills, stretching and playing rudiments on a pad. Nothing fancy, basic rudiments with different stickings and playing around with accents to get the hands flowing.
When it comes to songwriting, everyone has a different approach. Can you walk us through your philosophy and approach on composing drum parts for songs?
I love simplicity and enjoy finding patterns and ways to play things within simple ideas. When I'm learning material, I'll listen carefully to the song and think "what can I do here in a way that will portray the record but also add my personality to the table?".
From there, I shed the songs over and over to get as comfortable as possible and memorize every single aspect of it, that way it'll up my self confidence when it's time to play live. I rarely ever play a song exactly the same way two nights in a row.
Maybe only drummers would notice that, but I try to constantly find different spots in songs where I can try something different. Wether that is a different sticking pattern, a different fill, opening the hats in a different part of the measure, or maybe even playing open handed for a whole section. That way, I trick myself to always be engaged and to be as creative as possible.
What also seems to works for me is that every time I sit at the drum kit, I make a mental note of how lucky I am to be there. I remind myself of how much fun, how engaging it is to play drums and to make music and I give a silent thank you to the world for allowing me to do this as a job. As cheesy as that can sound, I literally thank my life right before I play my first note, open a big smile and keep it throughout the show.
Can you walk us through a day in your life (Tour and Non-Tour)?
I'm an avid runner, so I do my best to keep fit in general. On tour, I wake up early before lobby call and get my run, that makes a huge impact on my day. That way I also get to know many cities in the world through running, and I sort of keep a log of all my runs around the globe and make a hobby of it.
Keeping fit and eating healthy also helps me at night during the show - Mitski's show is over 22 songs long, barely stops between songs and I start a lot of them so feeling physically and mentally strong is a big part of the equation for me. Also not drinking alcohol was a huge game changer for me, I feel less drained during the show and wake up easier the next morning for my crazy runs. When I'm not touring I love spending time at home with my wife, cooking, reading, listening to podcasts and sometimes training for some crazy races that I'm into (marathons, obstacle course races, relay races, etc…). I also love playing hometown gigs in NYC, so I try to make myself available as often as possible.
What are some products that you would recommend to a percussionist?
I've played Zildjian cymbals since I can remember. Joining as an endorser was a childhood dream come true and I think they're the best cymbals in the world. For years I played small percussion gigs using a foldable cajon and that's an awesome piece of gear to have for convenience.
I carry around the Big Fat Snare Drum everywhere I go; you can get an average backline snare sounding real deep in no time. I usually have the LP red hi hat attachable tambourine above my hats and love playing long patterns on them when I'm leading on the ride or floor tom.
Can you walk us through your drum kit / stick set up?
I play and endorse Zildjian, Evans and Pro Mark and really love what they make. For the vast majority of the time, I'm using 17" crashes as Hi Hats; and a general mix of K Custom Dark cymbals with A Customs. I really enjoy how they blend, specially 19" and 20" crashes
I play an incredible Ludwig kit when touring in North America and a bunch of Roland stuff: with Mitski, the SPDS-X sampler pad and the BT-1 trigger bar.
What is one piece of advice that you would give to a percussionist that is planning to pursue a career in music?
Put the time into it. Practice as much as you can, play with as many different musicians as possible, be humble and surround yourself with people that are better than you. Learn from them and remember that there's always more to learn and that you never really know enough. If you truly put the time and work into it, then the playing should come as second nature. Once that happens, relax and trust the process.
Also, you can think about this: people aren't just hiring you to play drums. They're hiring you for the many years of work you've put into it, for the personality you've built through the years and for the attitude you bring to the table.
What are some projects that you are excited to work on this year?
As I write this, we just wrapped an awesome sold out Australia/Asia tour in January/February and have a packed year ahead (e.g.: some major festivals like Fuji Rock in Japan, Lollapalooza) and headlining tours, so I'm really looking forward to the rest of 2019.
Who are some of your favorite drummer(s) and why?
Jeff Porcaro has been my #1 drummer since I can remember. His sensibility, his touch, his groove, the grace he brought to everything he played on has always inspired me and continues to do so. Rich Redmond is an incredibly badass drummer who means every note he plays. His workshop is wisely called CRASH (commitment, relationships, attitude, skills and hunger) and that says IT ALL. If you bring all of that to the table, then you're doing something right.
Neil Peart was the first reason I wanted to play drums. His playing on Moving Pictures literally felt like he was talking to me and telling me to go learn drums. Carter Beauford of the Dave Matthews Band was a huge influence on me growing up. I had a DMB cover band in Brazil, and even though I didn't necessarily attempt to copy Carter while playing live, studying his playing helped me tremendously, especially feeling comfortable playing open handed style and thinking of creative variations to playing fills.
Steve Jordan is a groove king and I don't get tired of listening to him; his playing on John Mayer's CONTINUUM is some of the most incredible playing I've heard. I've also been digging Dave Elitch a lot lately and would love to take some lessons with him; his knowledge on body mechanisms related to drumming is off the charts.
I basically admire all versatile drummers, especially the ones who appreciate simplicity and can mean a lot by doing very little. That to me is where the center of drumming lays.
Website: www.brunodrums.com
Instagram: @brunodrums
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Epeleuton Platform
Afimmune receives method of use patent allowance for Oral AF102 in the US
Afimmune receives a patent allowance for Oral AF102 in the US
Afimmune Announces Positive Data with Epeleuton from Preclinical Atherosclerosis Studies
Published by Adelle McGourty at December 18, 2018
Dublin, Ireland, 18th December 2018 – Afimmune, a privately held clinical stage drug discovery and development company, today announced receipt of allowance for a patent application in the United States of America (US). The allowance protects the use of the Company's lead compound AF102 (15-HEPE) in a number of conditions affecting human primary organs including the liver.
The United States Patent and Trademark Office (USPTO) has allowed the patent application entitled "Compositions comprising 15-HEPE and methods of using the same" with serial number 15/841,363 to grant. This patent will provide exclusivity for broad method of use claims protecting AF102 for inhibiting and relieving conditions such as fibrotic and inflammatory disorders. These claims will be protected until 2036 in the US.
Mr. Tien Nghiem, Director of Product Development and Intellectual Property at Afimmune commented: "The allowance of this patent further strengthens the AF102 patent portfolio which includes granted patents in the US, Europe as well as other jurisdictions. Afimmune continues to prosecute other patent applications for AF102."
About Afimmune
Afimmune, headquartered in Dublin, Ireland, is a clinical stage drug discovery and development company working on inflammatory conditions of the human primary organs including the liver. Afimmune has two separate Phase 2 trials ongoing at present exploring the therapeutic effect of AF102 in patients with non-alcoholic fatty liver disease (NAFLD) and Alcoholic Hepatitis (AH). AF102 has been granted Fast Track Designation as an investigational treatment for patients suffering from NASH (Non-Alcoholic Steatohepatitis) with liver fibrosis by the US Food and Drug Administration (FDA).
Afimmune: [email protected]
Afimmune:
Join our mailing list to receive updates about key developments in Afimmune. We value your privacy and have a zero tolerance spam policy. This is also a low volume list.
Copyright 2020 - Afimmune Limited (Company Number: 587618), Trintech Building, South County Business Park, Leopardstown, Dublin 18, Ireland
Telephone: +353 1 2946380 | Email: [email protected]

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When you stay at Ana Mandara Luxury Bed & Breakfast in Port Macquarie, you'll be by the ocean and convenient to Mid North Coast Maritime Museum Pilot Boat Shed and Glasshouse Cultural Centre. This 4-star bed & breakfast is within close proximity of Port Macquarie Museum and Port Macquarie Courthouse.
Make yourself at home in one of the 4 air-conditioned rooms featuring refrigerators and flat-screen televisions. Rooms have private balconies. Complimentary wireless Internet access is available to keep you connected. Private bathrooms have complimentary toiletries and hair dryers.
Take advantage of recreation opportunities such as a spa tub or take in the view from a terrace and a garden. Additional features at this bed & breakfast include complimentary wireless Internet access, a fireplace in the lobby, and tour/ticket assistance.
Featured amenities include complimentary newspapers in the lobby, luggage storage, and laundry facilities. A roundtrip airport shuttle is complimentary (available on request).
To make arrangements for check-in please contact the property ahead of time using the information on the booking confirmation. Airport shuttle service is available on request from 9 AM to 4 PM. Fees may apply. Contact the property in advance to make arrangements. Guests with dietary restrictions or food allergies should contact this hotel in advance. Contact the office using the information on the reservation confirmation received after booking.


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Q: How to export webpack modules into global variables I am trying to bundle all the dependencies into one file and use it in other js files. This is the code for bundling the dependencies.
return gulp.src('./dependencies.js')
    .pipe(webpack({
        output: {
            library: 'home'
        }
    }))

dependencies.js is just a file with a bunch of requires: e.g
require('angular');
require('toastr');
require('...');

I've tried playing around with output.library but I wasn't able to access the modules doing window.toastr or window.home.toastr. window.home was just an empty object {}.
How would I be able to bundle all the dependencies and access them in my other javascript files as a global variable?

A: To specify global exports from modules you can use ProvidePlugin
With it you can export your module as a global var my:
webpack({
    ...
    plugins: [
        new webpack.ProvidePlugin({ my: './relative/path/to/your/bundle.js' })
    ]
    ...
})

Or you can try your home library name instead of the path (probably it would also work)
But I would rather recommend to use DllPlugin to bundle group of modules into one file and then use original modules names as a references. Webpack will analyze your references and decide when it can use existing bundle instead of doing new chunks. This way you can easily change bundle content in config without changing your code.

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Rolly Waters is still around. He's just gone underground for a while. He hasn't retired. He hasn't quit. I've got an 89,000 word manuscript featuring Rolly stored on my computer. It's called Ballast Point Breakdown and I think it's a darn fine mystery novel. But it probably won't see publication anytime soon.
This all started when the option for Rolly Waters novel #4 was dropped by my publisher last year. I did some looking around, but found it's tricky getting a new publisher to pick up a series partway through. And I wasn't ready to take on self-publishing again.
So I took some time off, at least from the business end of the writing game. I had personal reasons, as well, for taking a little break, transitions both challenging and affirming.
But I've kept writing. Woodshedding, I'd call it. Practicing. Learning. In fact, I've been pretty darn busy on the creative side. I hope to send out some official announcements in the next few months, but here's a few things I've been working on.
1. A short story entitled The Old Monsters Bar, which will be published in January.
2. The script for a podcast version of Desert City Diva. No dates on this yet, but I am working with an independent producer to make it happen.
3. A collaborative project with San Diego artists and writers which will have a gallery show in early 2019.
4. A historical mystery novel, set in San Diego in 1891, which I'm shopping to agents right now. The working title is The Stingaree Solution. I have high hopes for this one. I had a lot of fun doing the research and writing it.
So I apologize to anyone who's been hoping to hear from Rolly Waters. He will be back. I'm just not sure when. Thanks to everyone who's been a fan, and a friend.


I'm befuddled: Where are you?
I've not the faintest, vague-est clue.
I haven't looked; perhaps I'd best.
Think of it from 'pon my bed.
Maybe you're at the store; maybe lying on the floor?
Or in a tree? In the sea?
Or sipping wine in a winery?
Are you walking 'round on stilts?
Watering flowers so they won't wilt?
Catching fairies with a bowl of cream?
Or far off following your wildest dream?
Or everywhere? It is you call.
I know THAT 'coz I'm sitting there.


Frederick B. Churchill. 1989. "Toward the History of Protozoology," Journal of the History of Biology 22: 185-187.
Protistology (formerly called protozoology) is the scientific study of unicellular eukaryotes and their relatives — single cells as living organisms. Protists make up 57 of the 60 distinct "ultrastructural identities" of eukaryotes, with the macroscopic forms most familiar to us (plants, animals and fungi) nestled amongst the other three (Simpson and Patterson, 2007). An extraordinarily diverse assemblage of organisms, protists have distinctive genetic systems, numerous primary, secondary, and tertiary levels of symbiosis, and unique cytoskeletons, and they play important roles in food webs and as pathogens. Among them are some of the most serious human parasites, including the malaria parasites Plasmodium spp., Leishmania, Trypanosoma, Entamoeba and Trichomonas. Many protists, such as Chlamydomonas, Tetrahymena, and Dictyostelium, have become important experimental organisms in scientific and medical research.
What do the Protistology Collections include?
The Protistology collections at UMass focus on the unique aspects of protist biology, those not found in plants, animals and fungi, but which inform our understanding of the evolution of these macroscopic lineages. In addition to having the professional papers, lab notebooks and journals of some of the leading 20th century protistologists, the collection includes the world's primary repository of light and electron micrographs of protists. Due to the ubiquity and diversity of protists, the collections cross a broad range of disciplines and methodologies, from evolutionary biology to ecology, physiology, medicine, and public health.
For further information, please contact the Archivists.


The Cheyenne Office of the National Weather Service says brutally cold conditions across southeast Wyoming and the Nebraska Panhandle this morning poses an extreme frostbite danger.
Extremely dangerous, life-threatening wind chills are ongoing across southeast Wyoming & the western Nebraska Panhandle this morning. Many areas are experiencing wind chills of 25 to 35 degrees below zero, with some areas even approaching wind chills of -50! Frostbite can develop very quickly in these conditions, perhaps in as little as 5 minutes. Take extra precautions if spending any time outdoors this morning. Dress appropriately for extreme cold, dressing in layers and wearing a winter hat and mittens. If traveling, carry extra blankets in your vehicle in case of an emergency. Don't forget about your furry friends in these extreme conditions!


Vancouver, British Columbia, Canada, September 25, 2013. Sanatana Resources Inc. ("Sanatana" or the "Company": TSX-V: STA) announces further to its news release of August 14, 2013, that it will proceed with a private placement of 625,000 Units (the "Units") at the price of $0.08 per Unit for gross proceeds of $50,000 (the "Offering"). Sanatana is proceeding with the Offering in order to include one subscriber who wanted to participate in the private placement the Company closed on August 14, 2013 (the "August Offering"). The Offering is priced on the same terms as the August Offering. Specifically, each Unit will consist of one common share in the capital of the Company (a "Share") and one share purchase warrant (a "Warrant"). Each Warrant will entitle the holder to purchase one Share at a price of $0.12 per Share for a period of two years from the closing of the Offering.
Closing of the Offering and payment of the finder's fees are subject to a number of conditions, including receipt of all necessary corporate and regulatory approvals, including the TSX Venture Exchange.
All securities issued in connection with the Offering will be subject to a statutory hold period of four months plus a day from the date of issuance in accordance with applicable securities legislation. The net proceeds of the Offering will be used for general corporate purposes and to fund the costs associated with the hearing before the Ontario Mining and Lands Commissioner in connection with Trelawney Mining and Exploration Inc.'s ("Trelawney") application for easements over the Watershed Property (see the Company's news releases of April 29, 2013 and July 4, 2013).
Sanatana Resources Inc. is a Canadian mineral exploration and development company focused on its Watershed property in Ontario. Sanatana entered into an option and joint venture agreement with Trelawney Augen Acquisition Corp. (formerly Augen Gold Corp.) ("TAAC") which grants Sanatana an option to acquire up to 51% of the Watershed Property consisting of 46 mining claims totalling approximately 19,006 acres and located within the Townships of Yeo, Chester, Neveille and Benneweis. As at November 2012, Sanatana exercised its first option and is the legal and beneficial owner of 50% of the Watershed Property. Sanatana has until March 2016, to decide whether to exercise its right to acquire a further 1% in the Watershed Property. In June 2012 IAMGOLD Corporation completed its acquisition of Trelawney Mining and Exploration Inc. and became the sole indirect shareholders of TAAC. In 2013, Sanatana (i) expanded the Watershed Property by acquiring, for the benefit of Sanatana and TAAC, a 20% interest in three additional mining claims located in Yeo and Chester Townships, Ontario and (ii) staked, and is the legal and beneficial owner of a 100% interest in an additional mining claim located in Chester Township, Ontario.


text:
YouTube Gems thread.
By BCR Greg,
November 16, 2006 in Hamer Fan Club Messageboard
BCR Greg 724
BCR Greg
Hamer Authorized Dealer
Location:Central Pennsylvania
Interests:Repairing unrepairables.
MC5 - Motorcity Is Burning (Beat Club, German TV 1972)
Cool band if you don't watch them...
BCR Greg 35 posts
JGale 21 posts
mudshark 11 posts
tafkathundernotes 0
tafkathundernotes
Location:New Hampshire
Interests:Playing bass, drums, or guitar. Working on tube amps.
Fairly new video - has a bunch of scenes from an old 70's movie that I can't remember the name of: http://www.youtube.com/watch?v=vSvd5V6SPMM
80's pop metal chicks: http://www.youtube.com/watch?v=i1vxdS1BpKw
Did you know Ray Charles played sax?
A holiday greeting from Nerf Herder:
For those melancholy moments... http://www.youtube.com/watch?v=DxQ660DwEtw
Styx with Hamer content: http://www.youtube.com/watch?v=nEG0TdpwhAA...ted&search=
jerseydrew 3
jerseydrew
Location:Rockaway, NJ
Interests:Guitars and golf
This is going to be a good thread. I don't have any good YouTube video's at the moment because I'm at work, but I'll check when I get home.
The reason that I'm gonna like thread is all the vid's will be in a single thread. This way I can find everthing easier.
MCChris 9,907
MCChris
Location:Where the dying continues
Interests: Asking Why?
Let's keep them music related on the main board. If someone wants to start a similar thread for general videos on the OC, go for it.
Disturber 4,297
Disturber
Location:Stockholm SWEDEN. Home of the Pripps Blå and skärgårdsbrännvin.
Interests:Rocket science, small animals and the adventures of Pippi Longstocking.
Why can't I write cool notes that links to the link anymore?
Like Greg did. Why does he always get special treatment, damn.
Because I am the FUCKING MAN, that's why.
Damn Euroweenies.......
(I love you, Matthias, just don't tell anyone...)
Why Eddie WAS the man...
Here's some more - Friggin' KIDS! Making everybody look bad...
"Mindwalk" from Wilmington, MA: (ages 11 to 15)
Kings X cover:
Limelight:
Covering some Alan Holdsworth:
Hamerhack 221
Hamerhack
Location:Charlottesville, VA
14 Year Old Jimmy Page Skiffle TV Performance and interview:
http://youtube.com/watch?v=epXeC40P80o
HamerHokie 64
HamerHokie
Location:Baltimore, MD
Interests:College Football
You could see the seeds of Satanism already!!
Someone should initiate a skiffle revival. I would but I have no idea what the fuck it is.
Mr Fuzzy 1
Mr Fuzzy
Location:NYC
Interests:Award winning Graphic Artist., tainting pop culture in my own special way.
Kicking it old school with a showbiz flair
http://www.youtube.com/watch?v=YvC2_nsVJv0
http://www.youtube.com/watch?v=FALutagdHNw
TV Lip sync, but they got the moves.
http://www.youtube.com/watch?v=ERgrf6VSsS8
A more recent clip
Real Cool!
http://www.youtube.com/watch?v=WdRaQZCOEf4...ted&search=
http://www.youtube.com/watch?v=IDVxz8KD83Y...ted&search=
The Treniers
http://www.youtube.com/watch?v=qBORqEsHOns
http://www.youtube.com/watch?v=89IKUF0V_DY...ted&search=
silentman 128
silentman
Location:MA
This one pwns.
http://www.youtube.com/watch?v=-5Ym5g3DR1M
Damn. You started it!
Guest pirateflynn
1974 California Jam - Greg Lake with some chewing gum and a twelve string.
http://www.youtube.com/watch?v=y2wgfevulfU
thecajunboy 3
thecajunboy
Location:Bonfire Capital of the World
Interests:Guitars
Amps
Cooking
Peeing Outdoors
JohnnyB 3,356
JohnnyB
Location:Seattle, WA
Interests:Music, both to play and listen to, especially vintage vinyl LPs, playing electric bass when I can, guitars, vintage drums, mallet percussion, high end audio and home theater, bottom-feeding,
Skiffle, according to this article, is the British equivalent of American rockabilly. It has a sort of shuffling beat and has roots in folk, blues, and jazz.
John Lennon's original Quarrymen was formed as a skiffle group, and Lonnie Donegan, a Britisher, had that big '50s skiffle hit, "Does Your Chewing Gum Lose its Flavor?"
This one's called Hamer Ville and features chicks and beers
Gotta have one of
on a rowdy fan
Sensational Alex Harvey Band
These guys kicked ass!
A band that should have been bigger:
Not exactly "live" but good: Uriah Heep
jettster 628
jettster
mudshark 3,401
mudshark
Location:Groover's Paradise
Interests:writing, music, chess, photography
http://www.youtube.com/watch?v=Wp7S7SI0flQ
http://www.youtube.com/watch?v=WFbyiHyF07w...ted&search=
http://www.youtube.com/watch?v=kgKLUeW2sSg...ted&search=
Moose 271
Location:Oceanside, CA
DING DING DING DING DING We have a WINNER!
It's like a trainwreck at the end. Horrifying, but you can't look away! I couldn't stop laughing.
doody 0
Location:Mason City, Iowa
Interests:I can't play guitar.
rude mood 12 string
http://www.youtube.com/watch?v=sUdDLQQfteE
Pride and Joy 12 string
http://www.youtube.com/watch?v=hfPXl5mFob0
Gods gonna cut you down
http://www.youtube.com/watch?v=1e0EQlQXoEo
cordroad 1
cordroad
Location:Monongahela PA
Interests:My family and my guitars.
Adding this for all the Tele players here.
http://youtube.com/watch?v=4Edjvh2I6Xs&amp...=roy%20buchanan


text:
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If you need help in Applying, Renewing or Replacing a Passport, or reporting a Lost or Stolen Passport, you should contact the Passport advice line on 0844 496 0605. Please note that it can take AT LEAST 3 weeks to receive your passport; if you need one urgently then there are other services you can use. If you are living in the UK you can apply online and then Her Majesty's Passport Office will send it back to the stated address for you to check and sign and send back. In most cases, your new passport will be delivered by a Courier between 8am and 6pm Monday to Saturday, or it may come by Royal Mail Recorded Delivery.
If you wish to change any personal information, such as a name or address through marriage or changing a name by deed poll then call the passport office now and then will give you help and advice on how to go about this.
If you have lost your Passport or it has been damaged, or you believe it has been stolen, then you will need to replace it. The Passport office is solely responsible for civil registration services through the general register office and is the only issuer of United Kingdom Passports. HM Passport Office is responsible for the administration of civil registrations in England and Wales and providing passport services to British nationals who live in the United Kingdom and providing services in association with partners Foreign and Commonwealth offices to those residing overseas. If you are not travelling between now and 6 weeks then this service is ideal however if you are travelling within the next few weeks then we strongly recommend taking advantage of the Fast Track Service where you can receive your passport within 1 week or the Premium Service where you can receive your passport within as little as 4hrs. The above number is a standard rate helpline number which will not charge you a premium to call. Currently the Mayor of London, he previously served as the Member of Parliament for Henley-on-Thames and as editor of The Spectator magazine. Johnson was educated at the European School of Brussels, Ashdown House School, Eton College and Balliol College, Oxford, where he read Literae Humaniores. On his father's side Johnson is a great-grandson of Ali Kemal Bey, a liberal Turkish journalist and the interior minister in the government of Damat Ferid Pasha, Grand Vizier of the Ottoman Empire, who was murdered during the Turkish War of Independence.[5] During World War I, Boris's grandfather and great aunt were recognised as British subjects and took their grandmother's maiden name of Johnson.
Try as I might, I could not look at an overhead projection of a growth profit matrix, and stay conscious. He wrote an autobiographical account of his experience of the 2001 election campaign Friends, Voters, Countrymen: Jottings on the Stump. Johnson is a popular historian and his first documentary series, The Dream of Rome, comparing the Roman Empire and the modern-day European Union, was broadcast in 2006. After being elected mayor, he announced that he would be resuming his weekly column for The Daily Telegraph. After having been defeated in Clwyd South in the 1997 general election, Johnson was elected MP for Henley, succeeding Michael Heseltine, in the 2001 General Election. He was appointed Shadow Minister for Higher Education on 9 December 2005 by new Conservative Leader David Cameron, and resigned as editor of The Spectator soon afterwards. A report in The Times[22] stated that Cameron regarded the possible affair as a private matter, and that Johnson would not lose his job over it. The Conservative Party hired Australian election strategist Lynton Crosby to run Johnson's campaign. Johnson pledged to introduce new Routemaster-derived buses to replace the city's fleet of articulated buses if elected Mayor.
I believe Londoners should have a greater say on how their city is run, more information on how decisions are made and details on how City Hall money is spent. Ken Livingstone presides over a budget of more than ?10billion and demands ?311 per year from the average taxpaying household in London. Under my Mayoralty I am certain that London will be judged as a civilised place; a city that cares for and acknowledges its older citizens. The Mayor's biggest area of responsibility is transport, and I intend to put the commuter first by introducing policies that will first and foremost make journeys faster and more reliable.
The site depends on your feedback, so let us know what we're doing right, and what we're not. Alternatively you can pick up a form from the post office and fill it in and take it back to use the Post Office's check and send service.
The Passport Office will not be responsible for any applications or supporting documents that you send. If you are not at home they will leave a calling card explaining how you can rearrange delivery, or collect from your local, sorting office.
Unlike Her Majesties Passport Office we allow consumers to complete the document over the phone with a specialist answering all of your questions, guiding you through each step as well as advising you what to do next. In reference to his cosmopolitan ancestry, Johnson has described himself as a "one-man melting pot" — with a combination of Muslims, Jews and Christians comprising his great-grandparentage.[6] His father's maternal grandmother, Marie Louise de Pfeffel, was a descendant of Prince Paul of Wurttemberg through his relationship with a German actress.
They have two sons—Milo Arthur (born 1995) and Theodore Apollo (born 1999)—and two daughters—Lara Lettice (born 1993) and Cassia Peaches (born 1997).[13] Boris Johnson and his family currently live in Holloway, North London.
In 1999 he became editor of The Spectator, where he stayed until December 2005 upon being appointed Shadow Minister for Higher Education. He is also author of three collections of journalism, Johnson's Column, Lend Me Your Ears and Have I Got Views For You. On 2 April 2006 it was alleged in the News of the World that Johnson had had another extramarital affair, this time with Times Higher Education Supplement journalist Anna Fazackerley.
Yet Londoners have little confidence in the Mayor spending their money with care and prudence. It was here that David Cameron and all his supporters gathered to congratulate him on becoming Mayor of London.
This handy international passport template will really bring your role play to life - can be used with holidays, travel agents and airport role play!
Any time you have left on an existing passport will be added on to your one (up to a maximum of 9 months). NOTE – due to heavy demand, applications can take longer between April and September so please apply as soon as you can. You should do this quickly as any uncollected Passports will be returned to the Passport Office after 7 days. The busiest time of the year for passport applications is during the Summer months and so you should expect to wait the greatest amount of time between May to September each year.
Through Prince Paul, Johnson is a descendant of King George II, and through George's great-great-great grandfather King James I a descendant of all of the previous British royal houses.
His comic first novel Seventy-Two Virgins was published in 2004,[16] and his next book will be The New British Revolution, though he has put publication on hold until after the London Mayoral election.[17] He was nominated in 2004 for a British Academy Television Award, and has attracted several unofficial fan clubs and sites.
In 2004 he was appointed to the front bench as Shadow Minister for the Arts in a small reshuffle resulting from the resignation of the Shadow Home Affairs Spokesman, Nick Hawkins. It was first established in 2006 and provides trusted passport operations and and accurate and secure records of key events. In 1995 a recording of a telephone conversation was made public revealing a plot by a friend to physically assault a News of the World journalist. If you have any queries about this, then speak to one of the Customer advisors on 0844 496 0605. Payment for your new passport, if you are applying by post, can be made by debit of credit card by completing the appropriate section of the form, or by cheque or Postal Order, (payable to HM Passport Office). THESE VERY SAME ENFORCEMENT AGENCIES, WHO HAVE SWORN TO PROTECT AND SERVE, OUR COUNTRY, AND CITIZENS ,ARE BUT SOME, OF THE CORRUPT,GREEDY TRAITORS .ENGAGED IN THE TYRANNY AND TORTURE. The school district has moved to a biometric identification program, saying students will no longer have to use an ID card to buy lunch.A BIOMETRICS TO TRACK YOUR KIDS!!!!!i»?i»?A TARGETED INDIVIDUALS, THE GREEDY CRIMINALS ARE NOW CONDONING THEIR TECH! Paul Weindling, history of medicine professor at Oxford Brookes University, describes his search for the lost victims of Nazi experiments.
The chairman of the board at ESL a€" then proprietor of the desert wasteland in Nevada known as a€?Area 51a€? a€" was William Perry, who would be appointed secretary of defense several years later. EUCACH.ORG PanelIn a 2-hour wide-ranging Panel with Alfred Lambremont Webre on the Transhumanist Agenda, Magnus Olsson, Dr.
Henning Witte, and Melanie Vritschan, three experts from the European Coalition Against Covert Harassment, revealed recent technological advances in human robotization and nano implant technologies, and an acceleration of what Melanie Vritschan characterized as a a€?global enslavement programa€?.Shift from electromagnetic to scalar wavesThese technologies have now shifted from electromagnetic wave to scalar waves and use super quantum computers in the quantum cloud to control a€?pipesa€? a reference to the brains of humans that have been taken over via DNA, via implants that can be breathed can breach the blood-brain barrier and then controlled via scalar waved on a super-grid. Eventually, such 'subvocal speech' systems could be used in spacesuits, in noisy places like airport towers to capture air-traffic controller commands, or even in traditional voice-recognition programs to increase accuracy, according to NASA scientists."What is analyzed is silent, or sub auditory, speech, such as when a person silently reads or talks to himself," said Chuck Jorgensen, a scientist whose team is developing silent, subvocal speech recognition at NASA Ames Research Center in California's Silicon Valley.
We numbered the columns and rows, and we could identify each letter with a pair of single-digit numbers," Jorgensen said. People in noisy conditions could use the system when privacy is needed, such as during telephone conversations on buses or trains, according to scientists."An expanded muscle-control system could help injured astronauts control machines. If an astronaut is suffering from muscle weakness due to a long stint in microgravity, the astronaut could send signals to software that would assist with landings on Mars or the Earth, for example," Jorgensen explained. These are processed to remove noise, and then we process them to see useful parts of the signals to show one word from another," Jorgensen said.After the signals are amplified, computer software 'reads' the signals to recognize each word and sound. Our Research and Development Division has been in contact with the Federal Bureau of Prisons, the California Department of Corrections, the Texas Department of Public Safety, and the Massachusetts Department of Correction to run limited trials of the 2020 neural chip implant.
We have established representatives of our interests in both management and institutional level positions within these departments. Federal regulations do not yet permit testing of implants on prisoners, but we have entered nto contractual agreements with privatized health care professionals and specified correctional personnel to do limited testing of our products.
We need, however, to expand our testing to research how effective the 2020 neural chip implant performs in those identified as the most aggressive in our society. In California, several prisoners were identified as members of the security threat group, EME, or Mexican Mafia. They were brought to the health services unit at Pelican Bay and tranquilized with advanced sedatives developed by our Cambridge,Massachussetts laboratories. The results of implants on 8 prisoners yielded the following results: a€?Implants served as surveillance monitoring device for threat group activity. However, during that period substantial data was gathered by our research and development team which suggests that the implants exceed expected results. One of the major concerns of Security and the R & D team was that the test subject would discover the chemial imbalance during the initial adjustment period and the test would have to be scurbbed. However, due to advanced technological developments in the sedatives administered, the 48 hour adjustment period can be attributed t prescription medication given to the test subjects after the implant procedure. One of the concerns raised by R & D was the cause of the bleeding and how to eliminate that problem.
Unexplained bleeding might cause the subject to inquire further about his "routine" visit to the infirmary or health care facility.
Security officials now know several strategies employed by the EME that facilitate the transmission of illegal drugs and weapons into their correctional facilities.
One intelligence officier remarked that while they cannot use the informaiton that have in a court of law that they now know who to watch and what outside "connections" they have. The prison at Soledad is now considering transferring three subjects to Vacaville wher we have ongoing implant reserach.
Our technicians have promised that they can do three 2020 neural chip implants in less than an hour. Soledad officials hope to collect information from the trio to bring a 14 month investigation into drug trafficking by correctional officers to a close.
Essentially, the implants make the unsuspecting prisoner a walking-talking recorder of every event he comes into contact with. There are only five intelligence officers and the Commisoner of Corrections who actually know the full scope of the implant testing.
In Massachusetts, the Department of Corrections has already entered into high level discussion about releasing certain offenders to the community with the 2020 neural chip implants.
Our people are not altogether against the idea, however, attorneys for Intelli-Connection have advised against implant technology outside strick control settings.
While we have a strong lobby in the Congress and various state legislatures favoring our product, we must proceed with the utmost caution on uncontrolled use of the 2020 neural chip. If the chip were discovered in use not authorized by law and the procedure traced to us we could not endure for long the resulting publicity and liability payments. Massachusetts officials have developed an intelligence branch from their Fugitive Task Force Squad that would do limited test runs under tight controls with the pre-release subjects.
Correctons officials have dubbed these poetnetial test subjects "the insurance group." (the name derives from the concept that the 2020 implant insures compliance with the law and allows officials to detect misconduct or violations without question) A retired police detective from Charlestown, Massachusetts, now with the intelligence unit has asked us to consider using the 2020 neural chip on hard core felons suspected of bank and armored car robbery. He stated, "Charlestown would never be the same, we'd finally know what was happening before they knew what was happening." We will continue to explore community uses of the 2020 chip, but our company rep will be attached to all law enforcement operations with an extraction crrew that can be on-site in 2 hours from anywhere at anytime. We have an Intelli-Connection discussion group who is meeting with the Director of Security at Florence, Colorado's federal super maximum security unit.
The initial discussions with the Director have been promising and we hope to have an R & D unit at this important facilitly within the next six months.
Napolitano insisted that the department was not planning on engaging in any form of ideological profiling.
I will tell him face-to-face that we honor veterans at DHS and employ thousands across the department, up to and including the Deputy Secretary," Ms.
Steve Buyer of Indiana, the ranking Republican on the House Committee on Veterans' Affairs, called it "inconceivable" that the Obama administration would categorize veterans as a potential threat.
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text:
All-New Corvette is Revealed
April 15, 2014, will be the date of the release of a new variant of the seventh generation Corvette. You may have already seen the Z06 and the C7.R at the Detroit Auto show in January, but this isn't either of those models. While Chevrolet has confirmed the revealing, it has revealed little about the new variant. It is unknown at this time when the new model will be available at Classic Chevrolet.
Corvette fans may see a fixed-roof model or a special edition to help launch the 2015 model year. If it is the coupe, that model could be the new point of entry for those in the market for a new Corvette.
The 2014 model year started the seventh generation for the popular sports car. GM considered mid-engine and rear engine layouts for this model year, but stuck with the front-engine, rear-wheel drive version so production costs would not be too high. The LT1 engine featured in the 2014 model is a 376 cubic-inch V8 engine that puts out 455 base horsepower. If buyers add the optional performance exhaust, the base horsepower jumps up to 460. This is not the first generation to see the LT1 and may not be the last. The LT1 made its first appearance in the fifth generation.
Unlike the older version, this version of the LT1 features direct injection, an active fuel management system and variable valve timing. The engine is backed by a seven-speed manual or six-speed automatic transmission with paddle shifters.
Additional new features that you will probably see on future model years include a carbon fiber hood, a removable roof panel, different tail lights, and carbon-nano composite underbody panels. You may also see more aluminum instead of composite material in the body.
The 2015 Corvette is expected to have at least 625 base horsepower in a supercharged LT4 aluminum 6.2-liter engine.
For more information about the upcoming models, keep your eye on this space. For more information including safety, security, entertainment, and convenience features of the 2014 models, stop by Classic Chevy to test drive a new Corvette.
Auto News Chevrolet Dealerships Texas, Classic Chevrolet, Texas Chevy Dealer


Details: Enduro 110 volt, 550 watt electric servo motor - Easily adjust motor speed by using the built in adjustable speed-control knob. The Enduro servo motor can save you up to 70% of your electric use when compared to an equivalent power clutch motor. The Enduro servo motor is smaller and more lightweight than a comparable clutch motor. Smooth and quiet operation makes this servo motor virtually noiseless. Broad application, including high or low speed industrial sewing machines.


It's a boy! And you're no doubt dreaming of those little fingers and tiny toes. Who will he resemble? What will he enjoy playing? Will he have your sense of humor? A baby shower, while helpful in supplying and preparing for the little bundle of joy, is about celebrating the new life about to begin. You might want your shower to be as unique as your baby.
A lot of work can go into planning any party or function. There is the food choices, decorations, games and guests to invite to name a few. Perhaps your mind is flooded with ideas but you are having difficulty choosing relevant, organized and cute shower ideas. Or, maybe you are craft challenged and need not only ideas but helpful directions too. Well never fear! Revel in the following baby boy shower ideas with tutorials. Your celebration will be fantastic and fun for all.


Biography: Arlene Vidor has been studying and practicing photography since the 1970s. Prior to the digital age, her interest was primarily infrared photography. She loves to interpret the world through the camera, iphone and via digital manipulation.


Most people buy a home without really thinking through all of the important little details. There are many factors that should go into the decision to buy a home.
The first step is interviewing agents to find the right one. There are some very important questions to ask potential agents, including how long they've been doing real estate and what their ratio of list to sale prices is. These elements can help you find someone that will help you find the perfect home!
Along with selecting the right agent, it's best to talk with the bank early on about getting approved for a home loan. Knowing upfront what price point works for you can keep you from falling for a home that you can't afford.
Once you've selected a real estate agent and sorted out a home loan, the next step is to make a list of all the qualities that you desire in a home. There should be three columns: all of the qualities that you desire, all of the things that you absolutely need in your home, and any qualities that you refuse to settle for. Once you have a more clear idea of what you will and will not accept in your future home, you are ready to start viewing properties.
Something that many people forget to do while house-hunting is to bring a notebook and camera along to every single viewing. The reason this is so important is that it's very easy to forget all of the important details of a property that you saw three houses ago.


The last two posts I posted (posting a post? I never would have figured) took (rounded down to nearest minute) 8 and 12 minutes respectively to post. This is on Australian 1.5Mbit "broadband".
I miss my Singapore MaxOnline 8Mbit connection :(.


Preheat the oven to 350° and fill 12 muffin cups with paper liners. In a small bowl, combine the brown sugar with the flour, a pinch of salt and the cinnamon.
In another small bowl, whisk the granulated sugar with the cinnamon.
In a medium bowl, whisk the eggs with the butter, milk and vanilla until smooth.
In a large bowl, whisk the flour with the granulated sugar, brown sugar, baking powder, cinnamon and salt. Using a wooden spoon, stir in the wet ingredients until combined. Fold in the apple and the brown sugar swirl.
Spoon the batter into the muffin cups and sprinkle with the cinnamon sugar. Bake the muffins in the center of the oven for about 22 minutes, until a toothpick inserted in the center comes out clean. Let cool slightly before serving.


text:
A More Civil Dispute
Site Staff,
With long lines at the courthouse, people are turning to a quicker alternative.
Suppose you had your choice: you could wait in line behind tens of other litigants waiting to get their day in court — a wait that could last a year or more — or you could hire a private arbitrator and get yourself some speedy, private justice.
Which way would you go?
The field of "alternative dispute resolution" — ADR — is growing in New Hampshire for at least two reasons. The first, practitioners say, is the ability to settle civil cases rapidly and inexpensively, and obtain a better result than a court might provide. The other is the long line on the courthouse steps.
"The Constitution requires that the courts provide speedy, free access to civil disputes, but the system has been unable to do that because of the financial constraints put on it by the Legislature," notes attorney Tom Richards, executive director of the aptly named ADR firm Resolution Now in Concord.
According to the New Hampshire Supreme Court's website, the state courts will lose at least six days this year due to closures needed to meet budget cuts. Those closings, and the involuntary furlough of court employees on those days, results from a reduction of $3,100,000 in the judicial system's budget during the two-year cycle that began in 2009.
"The courts are underfunded and overstressed, and where people would normally be able to get into court within a year, that isn't happening, so where do you go to get it done?" Richards asks.
Firms like his provide one answer. It draws on a pool of retired Superior Court judges who can hear a case on a less-formal basis than a trial environment would require, and render decisions promptly. "If I got a call from a lawyer tomorrow, I could probably set up a hearing within 48 hours or less, and guarantee a written decision within 10 days " says Richards.
This kind of quick justice comes at a cost, but whether that's more or less than the cost of a trial depends on the particular case. Says Richards, "Our charges are $1,500 per party per day, of $800 for a half day or less. That's probably less than (litigants are) paying their own lawyers at $200 to $400 per hour. And a three to four day hearing with us could take eight to 10 days in the courts."
Where Resolution Now provides arbitration in which a neutral third party listens to the litigants and issues a decision that the parties are obliged to accept, other New Hampshire attorneys focus on mediation. That's a process in which the parties try to reach their own solution, with the support and occasional prodding by an impartial intermediary. In either case, the result is approved by a court and then has the same force as a decision made by the court itself.
Ora Schwartzberg specializes in family and divorce mediation from offices in Concord and Piermont. "Going to court on family issues can be very destructive emotionally and financially, and people don't necessarily get anything better for all their money and aggravation," Schwartzberg says. "In mediation, where people design their own agreements and act with integrity, they can come out being the good person they wanted to be as opposed to doing things out of the pressure of the litigation process."
Attorney Terry Shumaker with Bernstein Shur in Manchester says ADR is also effective in what he calls "fence cases." He observes, "It generally isn't really about the boundary, but the junk cars in the front yard or the loud music on Saturday nights. A good mediator can be incredibly effective by listening and grinding out why the parties are really in court, and can include things in the settlement that a court would have no power to order."
Shumaker calls himself "a true believer in ADR" because of the speed and relative ease of resolution that it can provide, especially in cases that just can't wait to get before a judge. "With the faster pace of life and business, the Internet and the speed of commerce, a lot of people don't have four years to wait around and be in the courts," he says. "In business, one side or the other may not even be around in two to four years."
He also notes that most cases are ultimately resolved outside of the courtroom anyway. "The Bar Association says 98.4 percent of cases filed settle before trial or appeal," Schumaker says, "so if a case is going to settle anyway, why not get on with mediation?"
But Schwartzberg says that depends on the mediator doing the job well — something that's not always certain, especially for litigants who can't afford their own attorney or choose not to hire one. "There are a lot of mediators contracting with the courts who are not experienced or not familiar with the law, and who are providing a disservice to the pro se litigants who come to the court and think they are getting professional help because it is being provided by the court system."
The reason, again, is money. "The court pays (mediators) $60 per hour with no preparation time and no travel time, although people are required to go to the courthouse," says Schwartzberg. "But it costs more than $60 per hour to run a law office, so the really good mediators work for the courts very infrequently, and the courts have less choice of who they can hire."
The lack of affordable expertise means outcomes can vary in quality, something a judge might miss while reviewing the agreement. "I've had clients six months after a divorce having all kinds of problems because the initial parenting plan was not adequate," says Schwartzberg.
When that happens there's not much a lawyer can do. "There's a right of appeal to the Supreme Court, but it's limited to an absolute error of law, prejudice or misconduct," Richards says. "It has to be a fairly egregious thing as opposed to the wide parameters in an ordinary court proceeding."
Yet the difficulty in undoing an unfavorable outcome does not seem likely to slow litigants from engaging in ADR — especially since New Hampshire courts require at least an attempt at out-of-court negotiations in all but a very few situations. And although ADR may help ease the backlog being exasperated by cost cutting in the courts, Richards notes that it's not the solution for every situation.
"The lack of funding is doing a lot of harm particularly in areas where people need emergency orders and decisions," he says. "More attention needs to be brought to the problem, and the Legislature needs to step up and say this is not acceptable." NH
Categories: Law & Politics


text:
The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease
Ion A. Hobai, Brian O'Rourke
The Na+/Ca2+ exchanger (NCX), a surface membrane antiporter, is the primary pathway for Ca2+ efflux from the cardiac cell and a determinant of both the electrical and contractile state of the heart. Enhanced expression of NCX has recently been recognised as one of the molecular mechanisms that contributes to reduced Ca2+ release, impaired contractility and an increased risk of arrhythmias during the development of cardiac hypertrophy and failure. The NCX has also been implicated in the mechanism of arrhythmias and cellular injury associated with ischaemia and reperfusion. Hence, NCX blockade represents a potential therapeutic strategy for treating cardiac disease, however, its reversibility and electrogenic properties must be taken into consideration when predicting the outcome. NCX inhibition has been demonstrated to be protective against ischaemic injury and to have a positive inotropic and antiarrhythmic effect in failing heart cells. However, progress has been impaired by the absence of clinically useful agents. Two drugs, KB-R7943 and SEA-0400, have been developed as NCX blockers but both lack specificity. Selective peptide inhibitors have been well characterised but are active only when delivered to the intracellular space. Gene therapy strategies may circumvent the latter problem in the future. This review discusses the effects of NCX blockade, supporting its potential as a new cardiovascular therapeutic strategy. 2004
Expert Opinion on Investigational Drugs
https://doi.org/10.1517/13543784.13.6.653
Intracellular Space
Antiporters
Cardiomegaly
SEA 0400
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
Arrythmias
Ischaemia
Na/Ca exchanger
Positive inotropes
Hobai, I. A., & O'Rourke, B. (2004). The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. Expert Opinion on Investigational Drugs, 13(6), 653-664. https://doi.org/10.1517/13543784.13.6.653
The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. / Hobai, Ion A.; O'Rourke, Brian.
In: Expert Opinion on Investigational Drugs, Vol. 13, No. 6, 06.2004, p. 653-664.
Hobai, IA & O'Rourke, B 2004, 'The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease', Expert Opinion on Investigational Drugs, vol. 13, no. 6, pp. 653-664. https://doi.org/10.1517/13543784.13.6.653
Hobai IA, O'Rourke B. The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. Expert Opinion on Investigational Drugs. 2004 Jun;13(6):653-664. https://doi.org/10.1517/13543784.13.6.653
Hobai, Ion A. ; O'Rourke, Brian. / The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. In: Expert Opinion on Investigational Drugs. 2004 ; Vol. 13, No. 6. pp. 653-664.
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abstract = "The Na+/Ca2+ exchanger (NCX), a surface membrane antiporter, is the primary pathway for Ca2+ efflux from the cardiac cell and a determinant of both the electrical and contractile state of the heart. Enhanced expression of NCX has recently been recognised as one of the molecular mechanisms that contributes to reduced Ca2+ release, impaired contractility and an increased risk of arrhythmias during the development of cardiac hypertrophy and failure. The NCX has also been implicated in the mechanism of arrhythmias and cellular injury associated with ischaemia and reperfusion. Hence, NCX blockade represents a potential therapeutic strategy for treating cardiac disease, however, its reversibility and electrogenic properties must be taken into consideration when predicting the outcome. NCX inhibition has been demonstrated to be protective against ischaemic injury and to have a positive inotropic and antiarrhythmic effect in failing heart cells. However, progress has been impaired by the absence of clinically useful agents. Two drugs, KB-R7943 and SEA-0400, have been developed as NCX blockers but both lack specificity. Selective peptide inhibitors have been well characterised but are active only when delivered to the intracellular space. Gene therapy strategies may circumvent the latter problem in the future. This review discusses the effects of NCX blockade, supporting its potential as a new cardiovascular therapeutic strategy. 2004",
keywords = "Arrythmias, Heart failure, Ischaemia, Na/Ca exchanger, Positive inotropes",
author = "Hobai, {Ion A.} and Brian O'Rourke",
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journal = "Expert Opinion on Investigational Drugs",
T1 - The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease
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AU - O'Rourke, Brian
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AB - The Na+/Ca2+ exchanger (NCX), a surface membrane antiporter, is the primary pathway for Ca2+ efflux from the cardiac cell and a determinant of both the electrical and contractile state of the heart. Enhanced expression of NCX has recently been recognised as one of the molecular mechanisms that contributes to reduced Ca2+ release, impaired contractility and an increased risk of arrhythmias during the development of cardiac hypertrophy and failure. The NCX has also been implicated in the mechanism of arrhythmias and cellular injury associated with ischaemia and reperfusion. Hence, NCX blockade represents a potential therapeutic strategy for treating cardiac disease, however, its reversibility and electrogenic properties must be taken into consideration when predicting the outcome. NCX inhibition has been demonstrated to be protective against ischaemic injury and to have a positive inotropic and antiarrhythmic effect in failing heart cells. However, progress has been impaired by the absence of clinically useful agents. Two drugs, KB-R7943 and SEA-0400, have been developed as NCX blockers but both lack specificity. Selective peptide inhibitors have been well characterised but are active only when delivered to the intracellular space. Gene therapy strategies may circumvent the latter problem in the future. This review discusses the effects of NCX blockade, supporting its potential as a new cardiovascular therapeutic strategy. 2004
KW - Arrythmias
KW - Heart failure
KW - Ischaemia
KW - Na/Ca exchanger
KW - Positive inotropes
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10.1517/13543784.13.6.653


Your stamina and determination – it's awesome.
They see you as a machine of stamina. Show your friends how awesome you are when you use your physical peak to raise money for homeless without shelter.
Running, cycling, swimming – or just plain walking. Ask your friends to donate if you beat your personal best.
Then you probably know people who are. Invite your fit friends to run, swim or have them drag you into something – because raising money to give dignity to homeless who need you is incredible.
Be the star of the after game party with your fundraising event.


text:
OECD iLibrary is OECD's Online Library for books, papers and statistics and the gateway to OECD's analysis and data. It replaced SourceOECD in July 2010.

OECD iLibrary contains content released by OECD (Organisation for Economic Cooperation and Development), International Energy Agency (IEA), Nuclear Energy Agency (NEA), OECD Development Centre, PISA (Programme for International Student Assessment), and International Transport Forum (ITF). All content is hosted by the OECD so users can find - and cite - tables and databases as easily as articles or chapters in any available content format: PDF, WEB, XLS, DATA, ePUB.

OECD iLibrary is listed in the Registry of Research Data Repositories re3data.org.

WTO iLibrary has been developed by the OECD publishing in relation to OECD iLibrary.

OECD Publications
The OECD releases between 300 and 500 books each year. Most books are published in English and French. The OECD also publishes reports, statistics, working papers and reference materials. All titles and databases published since 1998 can be accessed via OECD iLibrary.

Access
OECD iLibrary provides access to all OECD's publications, working papers and datasets, published since 1998 (and some older titles too) to anyone with an internet connection. It also offers premium services to subscribers. Any individual or organisation can purchase a subscription, but subscribers are usually universities and research organisations, businesses, governments and public administration, non-governmental organisation and think tanks.

References

External links
 OECD iLibrary
 Organisation for Economic Co-operation and Development

OECD
Libraries established in 2010
French digital libraries

redpajama_set_name: RedPajamaWikipedia


text:
Joyce Pelgrim (–c.1526) was an English stationer and printer.

Life
Very little is known about his early life. Most of the details about his life are known from the works of Edward Gordon Duff, who also wrote the article about him in the Dictionary of National Biography.

Career
Pelgrim was known not only for printing books but also as an astute bookseller, active in St. Paul's Churchyard between 1506 and 1510. He received patronage from William Bretton, a wealthy English merchant.

He collaborated with Henry Jacobi and Wolfgang Hopyl.

Bibliography
Pelgrim's notable books include:

 Ortus Vocabulorum.

It was printed for him in Paris, in 1504.

References

English printers


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The Avett Brothers debuted the quirky airport scene video for folky, upbeat single "Ain't No Man," that was directed by singer Scott Avett.
In the song, Scott Avett goes through the typical motions of walking through an airport, trying to get on to a flight. It's far from mundane for Avett's video character, who sings that it embodies: "dealing with fear and his journey to do what he was born to do." The moods of the passengers shift once he makes it through security. The blanket of stress transforms into smiles and joy. The Avett Brothers, once in their gate, are greeted by special guest NASCAR driver Jimmie Johnson as the airplane's pilot.
"Ain't No Man" is the debut single off their upcoming album True Sadness, out on June 24th.


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text:
Something incredible just happened in Hawaii
September 16, 2017 By Dan Taylor
A research crew is wrapping up an incredible project that could one day result in sending astronauts to the surface of Mars.
They've spent the last eight months living alone on a remote Hawaii volcano, and now they're heading home. Six NASA research subjects will leave their Mars-like habitat on Sunday and return to the world, and will once again be able to enjoy fresh fruits and meat.
The four men and two women were part of a project to recreate living conditions on the surface of Mars by going to one of the most unforgiving places on the world: a remote volcano in Hawaii. Everything about it was meant to imitate a human colony on Mars, including a self-imposed 20-minute delay on communications with the outside world, which is how long it would take to send a signal to the surface of the Red Planet.
Scientists are trying to better understand what kind of psychological effects humans who go to Mars will have to endure. This experiment will help NASA pick crews that have the traits needed to survive on a two to three years Mars expedition.
"A team of six volunteer scientists completed one of the most extensive studies of the demands of life on a distant world by closing themselves off to the rest of the world for eight months in an effort known as HI-SEAS," NASA said in a 2015 statement on a similar previous mission. "Their chore wasn't so much to stay alive, but to see how isolation and the lack of privacy in a small group affects social aspects of would-be explorers.
"The research is expected to bear directly on NASA's decisions when composing crews for future missions to Mars. The group also experimented with many budding technologies future Mars explorers could employ during real expeditions to the Red Planet. It was the third and longest of the simulation missions. The next simulation is planned to last a year. A mission to Mars may take two and a half to three years, with approximately half of that time on the planetary surface."


Manorville is a city in New York. So far we have accumulated 262 streets in Manorville and on these streets we have added 22,569 real estate properties.
Manorville is a hamlet and census-designated place (CDP) in Suffolk County, New York, United States. The population was 14,314 at the 2010 census. Manorville is served by the Eastport-South Manor Central School District and is mostly in the Town of Brookhaven, but its northeast corner is in the Town of Riverhead.


text:
Q: Set application state in iframe only Ok, what I'm trying to do is come up with a way to apply certain application settings (CSS to be exact) but only within an iframed version of the app.
If you've used Wordpress, I'm basically trying to implement a version of the theme live preview where it opens a version of the application in an iframe with theme changes made only to that instance of the site. I think it (Wordpress) does this by using JavaScript to change all the links to AJAX POST requests with the chosen theme as part the parameters.
I was thinking I might be able to do something similar by adding a page parameter (themePreview or something similar), detect that and apply the temporary (session) style properties. I already have a custom CssResourceReference that does this albeit without the page parameter detection though that seems simple enough.
My main problem is, I want the user to be able to navigate around the site within the iframe. To do so, I would need to maintain, persist or somehow inject the themePreview page parameter into all page requests when it is already set.
Does anybody know how to accomplish this or alternatively, have a better idea?

A: Links in wicket work by calling the urlFor method of the request cycle. This includes a URL renderer which all URLs are passed through when they are being generated.
If you:

*

*Write a sub class for UrlRenderer to add your themePreview parameter to all urls if it was a parameter in the request

*Write a sub class of RequestCycle and override the newUrlRenderer() to return your UrlRenderer.

*Create your own implementation of IRequestCycleProvider to provide your custom RequestCycle

*In your application class, in the init method, call setRequestCycleProvider passing your custom IRequestCycleProvider.

This way, if the themePreview parameter is present in a request, it will be automatically added to any URL that is generated and so will be present on any link within your iframe.