text:
Алексе́й Алекса́ндрович Семичёв (1893, Брянск — 1941, ГУЛАГ) — деятель ВКП(б), 1-й секретарь Коми обкома ВКП(б). Входил в состав особой тройки НКВД СССР.

Биография
Алексей Александрович Семичёв родился в Брянске в 1893 году. Участвовал в Первой мировой войне.

Член РКП(б) с 1919 г. Избирался секретарём укома РКП(б), ответственным секретарём окружкома ВКП(б).

В 1931 г. окончил Коммунистический университет имени Я. М. Свердлова.

С 11.12.1932 по 1936 гг. 1-й секретарь Обкома ВКП(б) Автономной области Коми. С 1936 по 2.11.1937 гг. 1-й секретарь Коми обкома ВКП(б). Этот период отмечен вхождением в состав особой тройки, созданной по приказу НКВД СССР от 30.07.1937 № 00447 и активным участием в сталинских репрессиях.

Завершающий этап
С ноября 1937 года решением ЦК ВКП(б) освобождён от обязанностей руководителя областной парторганизации и вызван в Москву, в распоряжение ЦК ВКП(б).

Арестован 5 июня 1938 г. Приговорён Военным трибуналом Московского округа войск НКВД 25 января 1941 г. Обвинялся по статьям 58-7 УК РСФСР, 58-8, 58-11 УК РСФСР. Приговор — ВМН. Определением Верховного суда СССР от 14.03.1941 г. ВМН заменена на 20 лет лишения свободы и 5 лет поражения в правах. Умер в ИТЛ. Реабилитирован 17 марта 1956 г..

Примечания

Ссылки
 Семичев Алексей Александрович // Сайт Alexanderyakovlev.org
 Семичев Алексей Александрович

Участники Первой мировой войны (Россия)
Первые секретари Коми обкома КПСС
Делегаты XVII съезда ВКП(б)
Руководители партийных органов, репрессированные в СССР
Репрессированные члены особых троек НКВД СССР
Выпускники Коммунистического университета имени Я. М. Свердлова
Умершие в ГУЛАГе
Посмертно реабилитированные в СССР


The ArchiMate® Specification, an Open staff usual, defines an open and self reliant modeling language for company structure that's supported via various software proprietors and consulting organisations. The ArchiMate language allows firm Architects to explain, examine, and visualize the relationships between enterprise domain names in an unambiguous means.
This booklet is the reliable specification of the ArchiMate 3.0 modeling language from The Open crew. ArchiMate 3.0 is a huge replace to ArchiMate 2.1.The ArchiMate 3.0 Specification helps modeling through the TOGAF® structure improvement strategy (ADM). New positive factors in model 3.0 contain parts for modeling the firm at a strategic point, akin to power, source, and end result. it is also aid to version the actual international of fabrics and gear. additionally, the consistency and constitution of the language were stronger, definitions were aligned with different criteria, and its usability has been more desirable in quite a few different ways.
• firm structure practitioners, corresponding to architects (e.g., company, program, details, strategy, infrastructure, and, evidently, company architects), senior and operational administration, venture leaders, and an individual dedicated to paintings in the reference framework outlined by way of the company structure.
• those that intend to enforce the ArchiMate language in a software program instrument; they are going to discover a entire and specific description of the language during this ebook.
• the tutorial neighborhood, on which we depend for amending and enhancing the language, in response to cutting-edge learn ends up in the company structure field.
Studienarbeit aus dem Jahr 2006 im Fachbereich Pädagogik - Schulpädagogik, be aware: 1, Martin-Luther-Universität Halle-Wittenberg (Pädagogik), Veranstaltung: Interaktion und Anerkennung - Fallseminar, Sprache: Deutsch, summary: Seit jeher haben sich große Denker mit der Frage beschäftigt, wie die Beziehungen zwischen den Subjekten beschaffen sind bzw.
Whereas there are a small variety of titles exploring Transactional research in particular academic settings, there is not any complete account of this sensible psychology for studying. academic Transactional research attracts jointly a crew of members from the foreign academic TA neighborhood, providing views from Europe, India, South Africa, Australia, Japan and the USA to provide an explanation for and illustrate the perform of this fascinating improvement in schooling.
A college is simply nearly as good as its imperative. This quip types the thesis of higher Principals because it offers a bird's eye view at the enactment of Haberman's 11 middle services of a celeb central. higher Principals is principal for 2 major purposes. First, the fulfillment hole among 20 million young ones in poverty and their mainstream opposite numbers is continuous to turn into even wider.
This transparent, trouble-free textbook provides scholars every thing they should learn about administration - with out pointless and costly 'extras'. Written for an undergraduate unit, this article presents insights into the tips, techniques and practices of administration, and indicates scholars how the realm of the sensible supervisor and the realm of administration concept should be priceless to each other.
Posted in Education Theory 1.


We often encounter school clients unsure about where to start the safety and emergency preparedness process. We strongly encourage conducting a safety and security assessment to identify the operational, environmental, regulatory or technological risk factors to define a planning baseline. We analyze existing plans and procedures to begin identifying gaps immediately.
Our consultants possess all-hazards emergency management planning and law-enforcement experience. We continuously enhance our assessment approach to ensure we incorporate the latest recommendations and lessons learned in school safety (e.g., Sandy Hook Advisory Commission Interim Report, Virginia Governor's School and Campus Safety Task Force).
Every client is unique, and as such, we tailor our site visit to individual campus needs. Our methodology applies across market sectors enabling CMCG to use lessons learned on new engagements. Our assessment reports identify campus-wide and building specific recommendations to improve safety and security through changes to infrastructure, as well as policies and procedures. Our recommendations attempt to balance our clients desire to remain a welcoming and open educational environment with the changing security needs of today's evolving risk environment.
Our final report includes a recommendations implementation matrix clients use to track progress.


Download "I freely admit that I learned a lot about the real meaning of military service from my time in this job. As many of you know, and as I have noted on"
For the teacher: Encourage children to locate Jammu and Kashmir on the map of India.
Again, Secretary Johnson, thanks so much for continuing to serve and taking care of our country. I appreciate it very much.
Navy Family Framework Version 1.0 November 2017 Introduction Our Navy is charged with maintaining maritime superiority. We execute this charge with our Navy team - our Sailors, civilians, and Navy families.
Commander, U.S. Pacific Fleet Change of Command Admiral Patrick M. Walsh 20 December 2012 Pearl Harbor, Hawaii. Welcome and aloha.
Adm. Greenert: Thank you. I guess we re [inaudible] and you all can hear me well enough.
Chief of Naval Operations Adm. Jonathan Greenert Remarks at Malaysia Armed Forces Staff College 11 February 2014 Adm. Greenert: Thank you. I guess we re [inaudible] and you all can hear me well enough.
Fall Semester Events & Announcements!
Thank you Rear Admiral Bill McQuilkin for that introduction and for your leadership here at United States Naval Forces, Korea.
Distinguished guests, special friends, ladies and gentlemen, and especially members of the U.S. Pacific Fleet Aloha!
This is our 8 th straight reunion, which is special as it marks the 10th year anniversary of these deployments.
... from the air, land, and sea and in every clime and place!
Respecting the Flag. This text has been provided courtesy of the Department of Veterans Affairs, Office of Public Affairs.


text:
Baalzebub
Ba'al-ze'bub (Hebrews Ba'al Zebub', בִּעִל זבוּב fly-lord; Sept. ὁ [v. r. ή] Βάαλ μυϊvαν) occurs in 2Ki 1:2-3,16, as the god of the Philistines at Ekron, whose oracle Ahaziah sent to consult. Though such a designation of the god appears to us a kind of mockery, and has consequently been regarded as a term of derision (Selden, De Diis Syris, p. 375), yet there seems no reason to doubt that this was the name given to the god by his worshippers, and the plague of flies in hot climates furnishes a sufficient reason for the designation. See FLY. Similarly the Greeks gave the epithet ἀπόμυιος, to Zeus (Clem. Alex. Protrept. 2, 38) as worshipped at Elis (Pausan. v. 14, 2), the Myiagrus deus of the Romans (Solin. Polyhist. 1), and Pliny (29. 6, 34, init.) speaks of a Fly-god Myiodes. As this name is the one used by Ahaziah himself, it is difficult to suppose that it was not the proper and reverential title of the god; and the more so, as Beelzebul (Βεελζεβούλ) in Mt 10:25, seems to be the contemptuous corruption of it. SEE BEELZEBUB. Any explanation, however, of the symbolical sense in which flies may have been regarded in ancient religions, and by which we could conceive how his worshippers could honor him as the god offlies, would appear to us much more compatible with his name than the only sense which can be derived from the Greek parallel. This receives some confirmation, perhaps, from the words of Josephus (Ant. 9, 2, 1), who says, "Ahaziah sent to the Fly (τῆς Μυῖαν), for that is the name of the god" (τῷ θεῷ). The analogy of classical idolatry would lead us to conclude that all these Baals are only the same god under various modifications of attributes and emblems, but the scanty notices to which we owe all our knowledge of Syro-Arabian idolatry do not furnish data for any decided opinion on this phasis of Baal. SEE BAALIM.
⇒Bible concordance for BAAL-ZEBUB.
⇒See also the International Standard Bible Encyclopedia.
← Baaltis
Baal-zephon →

redpajama_set_name: RedPajamaCommonCrawl


text:
VIP Apartment Photos
VIP Apartment Virtual Tour
VIP Giving
Why Choose VIP
A La Carte Amenities
Local Knowledge & Resources
VIP Announces Exciting New Rebrand
ST. LOUIS – May 5, 2020 - VIP Corporate Housing was established in 1997 and since has been a trusted name in the corporate housing space. The professional organization has a successful proven track record through an orchestrated internal work-flow, duty of care standards, consultative approach to temporary housing solutions, and innovation while never sacrificing their customer-centric and people-first culture. Now more than ever the company is trusted for best-in-class furnished luxury accommodations and full-service approach vs. a DIY (do-it-yourself) option that is offered by single-hosts, platforms, and pop-up providers.
In recognition of this, the company is refining its brand.
As a young company, VIP was identified with its Inspired 'Red' colored VIP logo for many years. In 2012, the company expanded throughout the Midwest and therefore the VIP logo changed to an Invigorating 'Orange' and adopted a globe to represent it's growth and expansion. Today, as one of the most trusted names in the Midwest and growing nationwide, the company has shifted to a Trusted 'Blue' to signify a sense of refinement, loyalty, trust, calm.
The change in the logo is fairly cosmetic by eliminating the globe while letting the trademark logo stand alone with an updated primary color and secondary color change.
As an overall brand refinement, the company has recently invested in updating it's company website, digital platforms, e-materials, apartment branding and sales information and social platforms all signifying a company that is refining it's image and strategy while staying true to engaging it's customers. Leadership wanted to reinvigorate the company's image and challenged its creative partner as they see the industry and world around it changing. This is the first phase of a multi-phase rebrand.
VIP Corporate Housing is a highly accredited national leading temporary housing provider. VIP offers fully-furnished and full-serviced apartments and housing solutions. VIP has maintained a tailor-made approach over decades to ensure each and every customer receives the most personalized service and product approach. To learn more about how our consultative approach or to book a reservation please contact:
Sales@VipCorporateHousing.com or toll free 888-249-5719.
www.VipCorporateHousing.com
Our Housing Solutions
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Phone: (888)249-5719 | Fax: (636)519-0541
© 2021 VIP Corporate Housing
State Alabama (AL)Alaska (AK)Arizona (AZ)Arkansas (AR)California (CA)Colorado (CO)Connecticut (CT)Delaware (DE)District of Columbia (DC)Florida (FL)Georgia (GA)Hawaii (HI)Idaho (ID)Illinois (IL)Indiana (IN)Iowa (IA)Kansas (KS)Kentucky (KY)Louisiana (LA)Maine (ME)Maryland (MD)Massachusetts (MA)Michigan (MI)Minnesota (MN)Mississippi (MS)Missouri (MO)Montana (MT)Nebraska (NE)Nevada (NV)New Hampshire (NH)New Jersey (NJ)New Mexico (NM)New York (NY)North Carolina (NC)North Dakota (ND)Ohio (OH)Oklahoma (OK)Oregon (OR)Pennsylvania (PA)Rhode Island (RI)South Carolina (SC)South Dakota (SD)Tennessee (TN)Texas (TX)Utah (UT)Vermont (VT)Virginia (VA)Washington (WA)West Virginia (WV)Wisconsin (WI)Wyoming (WY)
Number of Bedrooms 1 Bedroom2 Bedrooms3 Bedrooms
Approx. Monthly Budget
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Move Out Date (mm/dd/yyyy)


text:
Just announced! Canadian Pacific Holiday Train to pass through Wisconsin Dec. 6-8
Posted 4:08 pm, October 11, 2018, by FOX6 News, Updated at 04:12PM, October 11, 2018
Canadian Pacific's Holiday Train
MILWAUKEE — Officials with Canadian Pacific (CP) Railway just announced the Holiday Train will soon set out once again to entertain thousands of people — and celebrate 20 years of collecting food and raising funds for food banks across North America.
The U.S.-bound train will depart from Montreal on Nov. 25 and head south.
Sam Roberts Band and JoJo Mason entertain crowds at stops in Quebec, New York and Ontario. The Trews will then hop on board with Willy Porter in Chicago to complete the trip through Illinois, Iowa, Missouri, Wisconsin, Minnesota and North Dakota before arriving at their final destination in Weyburn, Sask. on Dec. 16.
Canadian Pacific Holiday Train stops in Wauwatosa
In Wisconsin, the train stops are as follows (subject to change):
Sturtevant Amtrak Depot: 7:20 p.m.
Milwaukee Amtrak Depot: 8:35 p.m.
Friday, December 7
Wauwatosa (Harwood Ave. crossing): 4:15 p.m.
Hartland (Level Crossing at Cottonwood Ave.): 5:45 p.m.
Oconomowoc (Silver Lake St.): 6:55 p.m.
Watertown (Brandt-Quirk Park): 7:55 p.m.
Columbus (Amtrak depot): 9:05 p.m.
Portage (Amtrak station): 1:15 p.m.
Wisconsin Dells (Amtrak station): 2:45 p.m.
Mauston (Division St. railway crossing): 4:15 p.m.
Tomah (Amtrak depot): 2:45 p.m.
Sparta (Corner of St. Water St. & Milwaukee St.): 6:40 p.m.
La Crosse (Amtrak station): 8:45 p.m.
CP is encouraging fans of the train to donate heart-healthy food, as everyone should have access to healthy, nutritious food, regardless of circumstances. This supports the mission of CP Has Heart, a program dedicated to improving the heart health of men, women and children in North America. To date, this program has raised over $15 million for cardiac care and research.
First-time CP Holiday Train stops this year include: Carberry, Man.; Gleichen, Alta.; Bensenville, Ill.; Ottumwa, Iowa; and Chillicothe and Kansas City, Mo. A full schedule is available at by CLICKING HERE.
Kids can ride Amtrak Hiawatha free on weekends throughout summer
'Help meet this need:' Red Cross issues urgent call for blood, platelet donations
Donors needed: Red Cross encourages eligible donors to give blood
1 killed in crash involving vehicle, train in Trevor in Kenosha County
'Facing a critical shortage:' Red Cross has significant need for type O blood
Driver killed in crash with Amtrak train headed to Chicago from Milwaukee
'$8 State Fair tickets:' Variety of deals, discounts on sale now for Wisconsin State Fair
Versiti Blood Center of Wisconsin issues emergency call for blood donations
Attention drivers: A look at the upcoming construction that could impact your commute
'Feels good to help people:' Tosa's Inflata-Palooza event raises money for families of fallen officers
Amtrak to begin bus route between Green Bay and Milwaukee
Kesha headlines UWM's PantherFest at BMO Harris Pavilion Sept. 6
Summerfest 2019: Getting to the Big Gig…and the acts you can see while you're there


text:
package main

import (
	"errors"
	"fmt"
	"gauja/heartbeat"
	"gauja/lineio"
	"gauja/linelog"
	"gauja/msg"
	"log"
	"net"
	"os"
	"os/signal"
	"time"
)

var (
	heartbeatPeriod = 10 * time.Minute
	connectTimeout  = heartbeatPeriod
	pongPeriod      = heartbeatPeriod / 2

	ErrInterruptSignal = errors.New("gauja: interrupt signalled")
)

func main() {
	interrupted := make(chan os.Signal)
	defer signal.Stop(interrupted)
	signal.Notify(interrupted, os.Interrupt)
	ds := heartbeat.Durations{
		ReadTimeout:  heartbeatPeriod,
		WriteTimeout: heartbeatPeriod / 10,
	}
	address := "irc.raek.se:6667"
	netConn, err := net.DialTimeout("tcp", address, connectTimeout)
	if err != nil {
		log.Fatal(err)
	}
	lines, sg := lineio.Manage(netConn)
	lines = linelog.Manage(lines)
	msgs := msg.Manage(lines)
	msgs = heartbeat.Manage(msgs, sg, ds)
	go func() {
		send := func(command string, parameters ...string) {
			msgs.W <- msg.MakeMessage(command, parameters...)
		}
		defer close(msgs.W)
		send("NICK", "gauja")
		send("USER", "gauja", "0", "*", "Gauja Bot")
		for _ = range msgs.R {
		}
	}()
	go func() {
		<-interrupted
		sg.Stop(ErrInterruptSignal)
	}()
	err = <-sg.NotifyOnStop()
	if err != nil {
		fmt.Println(err)
	} else {
		fmt.Println("Shutting down gracefully.")
	}
	time.Sleep(3 * time.Second)
}

redpajama_set_name: RedPajamaGithub


text:
Wolfraam-177 of 177W is een onstabiele radioactieve isotoop van wolfraam, een overgangsmetaal. De isotoop komt van nature niet op Aarde voor.

Wolfraam-177 kan ontstaan door radioactief verval van renium-177.

Radioactief verval
Wolfraam-177 vervalt door β+-verval naar de radioactieve isotoop tantaal-177:

De halveringstijd bedraagt 2,2 uur.

Radioactieve isotoop
Isotoop van wolfraam

redpajama_set_name: RedPajamaWikipedia


2008 INTERNATIONAL MXT 4X4 \ FACTORY ORIGINAL \ ONLY 17,800 MILES!
Color : – White Ext. w/ Black Leather Int.
More Details : – ONLY 17,790 DOCUMENTED MILES \ 100% ORIGINAL UNMODIFIED CONDITION \ IMMACULATE CONDITION THROUGHOUT \ TWO LOCAL ALBERTA OWNERS \ SPOTLESS HISTORY!
Absolutely zero modifications or alterations since new – this truck is in 100% factory stock original form. Under 18,000 miles and in extremely well cared for condition both inside and out. We have just completed a full service on this MXT including brand new brakes front and back, differential flush (invoice available), and oil service. It has successfully passed through our 200 point independent mechanical fitness assessment and drives without any issues as you would expect from a vehicle with mileage this low.
Ready for export to the USA or delivery worldwide – comes on an Alberta, Canada registered title with no liens. Truck is currently located in Calgary, Alberta, Canada.
Please view the photo portfolio and attached YouTube videos – if you require any further photos or videos please do not hesitate to ask.
The International MXT 4×4 produced only for the 2008 model year with a total of 1,500 worldwide produced.


text:
The Georgia Tech Yellow Jackets will return home after a two-game road trip. Georgia Tech and the Miami (FL) Hurricanes will square off in an ACC Battle at 3:30 p.m. ET Saturday at historic Grant Field's Bobby Dodd Stadium. The Yellow Jackets will strut after a win while Miami (FL) will stumble after a loss.
It was a close contest that could have gone either way, but Georgia Tech pulled off a 28-27 victory over the Virginia Tech Hokies last week. QC Zach Pyron and RB Dontae Smith were among Georgia Tech's leading playmakers as the former had a TD and 253 yards on 32 attempts in addition to rushing for a TD and 66 yards and the latter struck for a rushing touchdown. 56-yard touchdown shot from Pyron to WR Nate McCollum in the fourth quarter was one of the most memorable moments of the day.
Georgia Tech's defense was also present, as they had one interception and three fumbles. comics Clayton Powell-Lee picked up that interception and then rubbed salt into the wound bringing it the other way for a touchdown.
Meanwhile, the night started off rough for the Hurricanes last week, and it ended that way too. They suffered a crushing 45-3 loss at the hands of the Florida State Seminoles. Miami (FL) was in a difficult position at halftime, the score already at 31-3. QC Jacurri Brown didn't really make a difference for Miami (FL); Brown threw an interception and fumbled the ball once with just 37 passing yards.
This next game should be close, with Georgia Tech starting just 1.5 points behind. Those who play the odds have seen things come and go with Georgia Tech, which is 4-4 ATS.
The loss to Miami (FL) brought them down to 4-5 while the victory over Georgia Tech brought them down to 4-5. Giving up four turnovers, Miami (FL) struggled to keep the ball. We'll see if the Yellow Jackets can exploit this vulnerability.
Lancaster Fairfield Union clears Crooksville | Ohio High School Football Game Summaries


Create a breathtaking quilt using the well loved log cabin block with a twist in the Curvy Log Cabin Quilt, now in Blue Brilliance fabrics! The blocks are built in a very similar fashion to traditional log cabin blocks however, in the curvy log cabin blocks, the "logs" on one side are slightly larger than the "logs" on the other, giving the quit a curvy illusion. This visually stunning quilt showcases gorgeous hues – from deep navy, to subtle blues, each featuring a pearlescent accent! This one of a kind show stopper is sure to be a favorite you'll want displayed year round!
Quilt measures approximately 61½" × 71½".
A stunning coordinating pearlescent backing is available below!


text:
För konstnärer med samma namn, se Marianne Eriksson (född 1934) eller Marianne Eriksson (född 1952).

Jane Marianne Eriksson, född 17 maj 1952 i Brännkyrka församling i Stockholms stad, är en svensk politiker. Hon var ledamot av Europaparlamentet mellan 1995 och 2004 för Vänsterpartiet. Som EU-parlamentariker var hon engagerad i Utskottet för kvinnors rättigheter och jämställdhetsfrågor, i vilket hon var vice ordförande 1999–2004.

Källor

Externa länkar
Marianne Eriksson i Europaparlamentet

Ledamöter av Europaparlamentet från Sverige för Vänsterpartiet
Ledamöter av Europaparlamentet 1999–2004
Politiker från Stockholm
Födda 1952
Levande personer
Kvinnor


text:
În matematică 11-celule este un politop cvadridimensional  regulat autodual. Cele 11 celule ale sale sunt hemiicosaedrice. Are 11 vârfuri, 55 de laturi și 55 de fețe. Are simbolul Schläfli {3,5,3}, cu 3 hemiicosaedre (tip Schläfli {3,5}) în jurul fiecărei laturi.

Are ordinul de simetrie 660, calculat ca produs dintre numărul de celule (11) și simetria fiecărei celule (60). Structura de simetrie este grupul proiectiv liniar special abstract L2(11).

A fost descoperit în 1977 de Branko Grünbaum, care l-a construit prin lipirea hemiicosaedrelor împreună, câte trei la fiecare latură, până când forma s-a închis. A fost redescoperit independent de H.S.M. Coxeter în 1984, care a studiat mai în profunzime structura și simetria acestuia.

Politopuri înrudite

11-celule abstract conține același număr de vârfuri și laturi ca și 10-simplexul 10 dimensional și conține 1/3 din cele 165 de fețe ale sale. Astfel, poate fi desenat ca o figură regulată într-un 11-spațiu, deși atunci celulele sale hemiicosaedrice sunt "strâmbe", adică o celulă nu este conținută într-un subspațiu plan tridimensional.

Note

Bibliografie
  Peter McMullen, Egon Schulte, Abstract Regular Polytopes, Cambridge University Press, 2002.
  Coxeter, H.S.M., A Symmetrical Arrangement of Eleven hemi-Icosahedra, Annals of Discrete Mathematics 20 pp103–114.
  The Classification of Rank 4 Locally Projective Polytopes and Their Quotients, 2003, Michael I Hartley

Vezi și
 57-celule
 Fagure icosaedric, fagure hiperbolic regulat cu același simbol Schläfli {3,5,3}. (11-celule poate fi considerat că derivă din el prin identificarea elementelor corespunzătoare.)

Legături externe

  J. Lanier, Jaron's World. Discover, April 2007, pp 28-29.
   2007 ISAMA paper: Hyperseeing the Regular Hendecachoron, Carlo H. Séquin & Jaron Lanier, Also Isama 2007, Texas A&m hyper-Seeing the Regular Hendeca-choron. (= 11-Cell)

011


text:
Clippers | Reliever James Karinchak's demeanor like his idol's
Adam Jardy The Columbus Dispatch
There's not much physical resemblance between Clippers reliever James Karinchak and former New York Yankees starter Andy Pettitte. During his 18-year career, Pettitte won 256 games as a reliable left-hander with multiple pitches at his disposal.
Karinchak, a 2017 draft pick by the Cleveland Indians, is rapidly pitching his way into contention for a significant bullpen role as a right-handed power pitcher. And yet, as he rattled off the names of pitchers he admired as a child, Pettitte was one of the names he dropped while standing in the long hallway outside the Clippers clubhouse hours before a game against Louisville last week at Huntington Park.
How does a right-handed reliever draw childhood inspiration from a left-handed starter?
"He was just a gamer, man," Karinchak said. "He went out there and competed anytime he got the rock."
With a combination of that demeanor and two nasty pitches, Karinchak, 23, has pitched himself onto the Indians' radar in short order.
After opening the season at double-A Akron, Karinchak was promoted to the Clippers on May 3 and picked up right where he had left off by striking out eight batters in his first three innings and not allowing a run. But then, after injuring his right hamstring while running, he went on the disabled list May 11 and did not return until July 24.
"I think one of the things he had to grow the most was understanding the workload he puts in, and if you overwork, sometimes you fatigue, and then you get hurt," Clippers pitching coach Rigo Beltran said. "I think that's what happened. So he's starting to understand what it feels like when his body is fatigued, when to back off, and when not to."
Since his return, Karinchak has made 15 appearances totaling 12 1/3 innings, allowing nine earned runs. He has struck out 29 but allowed 12 walks.
"He's understanding that execution is a big part of the game now, not just trying to throw and overpower people," Beltran said. "He has to be able to throw that curveball for a strike. He's got to be able to locate that fastball and not just try to overpower some hitters."
It's been the first blip on the radar for a pitcher who through his first 96 professional innings had struck out 172 hitters. In early May, Indians manager Terry Francona described Karinchak as having two "wipeout pitches," which Beltran described as his 99-mph fastball and 12-to-6 curveball.
Karinchak said he's back to the form he had at the beginning of the season. Six of his runs allowed after the injury came in two appearances, and he has allowed two runs in his past nine innings while recording 20 of his 27 outs via strikeout.
"I didn't assimilate to game speed as fast as I'd like to (when I came back)," he said. "I came here and was really wild. I was pitching pretty bad the first week, but after that, things started clicking again, and I feel I'm pretty close to where I was."
ajardy@dispatch.com
@AdamJardy


Systemic Prevention Programs for children can help enhance the way they currently function and prevent later distress as well as be beneficial to the family and the community in which the children live. These types of preventive programs are shown to reduce the cost of mental health care. Systemic Prevention Programs can mean an improved quality of life as well as reduce illness and early death.
According to the National Research Council and Institute of Medicine in 2009, roughly 14 to 20 percent of children are diagnosed with an emotional, mental, or behavioral disorder. Children who are at risk for violence, substance abuse or other such issues would also be ideal candidates for Systemic Prevention Programs.
The Patient Protection and Affordable Care Act and the U.S. National Prevention Strategy both ask society to add more preventive services in order to improve individual, family and community life. There is a general shift toward wellness and prevention, which Systemic Prevention Programs are designed to meet.
Preventive services that are administered early and in a focused way can reduce the length and seriousness of abnormal functioning. Children can learn better coping strategies and problem-solving skills early in their lives, which can result in more positive and productive lives.
On a larger scale, Systemic Preventive Programs can address inequities in the areas of education and socio-economic standing if there are inconsistencies based on gender, racial or other group factors. They can also provide a bridge for families to work with their community and school system in order to improve the overall environment. Well-paying jobs, better social policy and more effective services may result.


text:
Q: Metropolis-Hastings Algorithm within Gibbs Sampling I have this $f$ function below.
$$
f(x_1,x_2)\propto \left(\dfrac{x_1}{x_2}\right)\left(\dfrac{\alpha}{x_2}\right)^{x_1-1}exp\left\{-\left(\dfrac{\alpha}{x_2}\right)^{x_1} \right\}I_{R^+}(x)
$$
where $\alpha > 0$.
I would like to estimate expected values and variances of $x_1$ and $x_2$ by using Gibbs Sampling or Metropolis-Hastings algorithms.
First of all, I tried to run Metropolis-Hastings algorithm, however, finding proper proposal distributions for both random variables is too hard. I tried some known distributions such as Gamma, Weibull or Exponentials, because they have the support of  $x_1$ and $x_2$, I did not get any good results, considering the plots of Markov Chains I got were too bad.
Another solution that I tried was Gibbs sampling. I tried to find full conditionals, i.e., $f(x_1|x_2)$ and $f(x_2|x_1)$ which are $x_1$ given $x_2$ and $x_2$ given $x_1$, respectively.
I found $f(x_1|x_2)$ as follows:
$$
f(x_1|x_2)\propto x_1 \beta^{x_1}\exp\left\{-\left(\beta \right)^{x_1} \right\}
$$
where $\beta=\dfrac{\alpha}{x_2}$ and $0<x_1<\infty$.
I tried to derive a standard distribution by using transformation. Thus, I made the change of variable with $\left(\beta \right)^{x_1}=y$.  In the end I get the function below.
$$
g(y|x_2)\propto ye^{-y}e^{-e^{-y}}
$$
The last two terms, here, resemble to a Gumbel Distribution with shape parameter $\mu=0$ and scale parameter $B=1$. Thus, Gumbell distribution has a support of $(-\infty, +\infty)$, that was not the case because, here $y$ has a support of $(-\infty, 0)$. So, I thought about truncating the Gumbel distribution, and then using acceptance rejection method to get random numbers of $y$'s. However, that did not work out, either because according to this method, the unknown $g(x)$ function, which is $y$ here, must be within $(0,1)$ to compare it with a uniform random number. So, I left it, here and thought maybe I can run MH for $x_1$ within Gibbs sampling. For that, once again, I truncated Gumbel distribution but this time for the support $(0, \infty)$. Because I assumed, since I can derive somewhat truncated Gumbel distribution for $f(x_1|x_2)$, this truncated Gumbel distribution might be a good proposal distribution for $x_1$, overall.
I got the probability distribution function (pdf) of truncated Gumbel distribution as given in below:
$$
f(x)=\frac{\dfrac{1}{B}e^{-{\dfrac{(x-\mu)}{B}+e^{-\dfrac{(x-\mu)}{B}}}}}{1-e^{-e^{\frac{\mu}{B}}}}
$$
and its cumulative distribution function (cdf) given as follows:
$$
F(x)=\dfrac{e^{-{e^{-\dfrac{(x-\mu)}{B}}}}-e^{-e^{\frac{\mu}{B}}}}{1-e^{-e^{\frac{\mu}{B}}}}
$$
Since I need to generate new random variates for MH algorithm, I need the inverse of this cdf. I will generate a new $z$ from $Uniform(0,1)$ and put it in the inverse of CDF of this distribution to get a random variates from truncated Gumbel distribution. The inverse cdf is given below:
$$
x=-B~ln\left\{-ln\left[z\left( 1-e^{-e^{\frac{\mu}{B}}} \right) + e^{-e^{\frac{\mu}{B}}} \right] \right\}+\mu
$$
Anyway, now it's turn for $f(x_2|x_1)$ which is $x_2$ given $x_1$.
$$
f(x_2|x_1)=\dfrac{1}{{x_2}^{x_1}}\exp\left\{-\dfrac{\gamma}{{x_2}^{x_1}} \right\}
$$
where $\gamma=\alpha^{x_1}$ and $0<x_1<\infty$. Thus, I made the change of variable with $\dfrac{1}{{x_2}^{x_1}}=t$.  In the end I get the function below.
$$
g(t|x_1)\propto \exp\{-\gamma ~ t \}~t^{-\dfrac{1}{x_1}}
$$
At first, I thought this was a Gamma distribution with the shape parameter $a=-\dfrac{1}{x_1}+1$ and scale parameter $b=\gamma=\alpha^{x_1}$. It seems, no doubt, a gamma distribution just because here $x_1$ is a constant because it's given/known. But the problem comes when it is applied. Because when I do Metropolis-Hastings within Gibbs, things get a bit complicated. Since I am going to update $x_1$ and put it in conditional distribution $g(t|x_1)$ in order to get $t$'s random variates,so then, I am going to inverse the transformation $\dfrac{1}{{x_2}^{x_1}}=t$ in order to get $x_2$'s. However, the parameters of gamma distribution creates a big problem.
As you know Gamma distribution has two parameters which is greater than zero. Here, $b=\gamma=\alpha^{x_1}$ is not a big deal, because $0<x_1<\infty$ so $b>0$. HOWEVER, in order to get $a>0$, the shape parameter, I need to generate $x_1>1$ which is impossible because  $0<x_1<\infty$.
I realized this problem long after I wrote and run the code, which giving me "NaN" for $x_2$ because the problem I talked above. I did what I said. I gave truncated Gumbel distribution as a proposal distribution for $x_1$ and run Gamma distribution for full conditional of $x_2$.
My initial values are 1 for each of $x_1$ and $x_2$. I am calculating acceptance ratio for $x_1$ since I run Metropolis-Hastings on it. I update each $x_1$ for each iteration in the parameters of Gamma distribution for $x_2$.
M=1000;
x=zeros(M+1,2);
t=zeros(M,1); %I create a Mx1 vector for inversing the transformation of x_2
alpha=2; % arbitrarily picked alpha value for my function
mu=0; %the shape parameter of truncated Gumbel distribution
beta=1; %the scale parameter of truncated Gumbel distribution

fx=@(x1,x2)((x1/x2)*((alpha/x2)^(x1-1))*\exp(-1*((alpha/x2)^x1))); %the function I have
gx=@(x1)(((1/beta)*\exp(-(((x1-mu)/beta)+\exp(-((x1-mu)/beta)))))/(1-\exp(-\exp(mu/beta)))); %the pdf of truncated Gumbell distribution

alpha21=@(x1)((-1/x1)+1); %the shape parameter of Gamma distribution for x2
beta21=@(x1)(alpha^(x1)); %the scale parameter of Gamma distribution for x2

acceptance_ratio=0;

t(1,1)=1;
x(1,1)=1;
x(1,2)=1;

for i=2:(M+1)
        old=fx(x(i-1,1),x(i-1,2));
        oldprob=gx(x(i-1,1)); %finding probabilities of x1's from truncated Gumbel distribution
        ex=x(i-1,1);

        z=unifrnd(0,1);
        t=(-beta)*log(-log(z*((1-\exp(-\exp(mu/beta))))+\exp(-\exp(mu/beta))))+mu; %inverse of cdf of truncated Gumbel distribution

        x(i,1)=t;
        new=fx(x(i,1),x(i-1,2));
        newprob=gx(x(i,1));
        acceptance_prob=min(1,new*newprob/(old*oldprob));
        if unifrnd(0,1)>acceptance_prob
            x(i,1)=ex;

        else
            acceptance_ratio=acceptance_ratio+1;
        end

        t(i,1)=gamrnd(alpha21(x(i,1)),beta21(x(i,1))); %updating the parameters of Gamma distribution in each iteration
        x(i,2)= t(i,1)^(-1/x(i,1));
end
mean(x)
var(x)
AR=acceptance_ratio/M

I think I am right at what I am doing. I know my problem. But I am stuck at it. I cannot find any solution. Would you care to help me?

A:
Are you sure the joint density$$f(x_1,x_2)=\left(\dfrac{x_1}{x_2}\right)\left(\dfrac{\alpha}{x_2}\right)^{x_1-1}\exp\left\{-\left(\dfrac{\alpha}{x_2}\right)^{x_1}
> \right\}\mathbb{I}_{\mathbb{R}^*_+}(x_1,x_2)$$ is integrable?

When I consider the conditional$$f(x_2|x_1)=\dfrac{1}{{x_2}^{x_1}}\exp\left\{-\dfrac{\gamma}{{x_2}^{x_1}} \right\}$$ it should be a proper probability density if the joint above is a proper density. However, when considering the case $x_1=1$, it simplifies to $$f(x_2|x_1=1)=\dfrac{1}{{x_2}}\exp\left\{-\dfrac{\gamma}{{x_2}} \right\}$$ which does not integrate over $(0,\infty)$ since the change of variable $\eta=1/x_2$ leads to the density $$f(\eta|x_1=1)=\eta\exp\left\{-\gamma\eta\right\}\eta^{-2}.$$ Which is equivalent to $\eta^{-1}$ when $\eta\approx 0$. Your change of variable $t=x_2^{-x_1}$ shows the same issue occurs when $x_1\le 1$.
Note: When you operate the change of variable $$x_1\longrightarrow\left(\beta \right)^{x_1}=y$$ the new variate $y$ is either supported by $(0,1)$ or $(1,\infty)$ depending on whether or not $\beta<1$. But this is irrelevant relative to the main issue.

A: $f(x_1,x_2)$ is not a density function since it is not integrable.
Note that
$$\int_0^{\infty}\int_0^{\infty} f(x,y)dydx \geq \int_1^{\infty}\int_0^{\infty} f(x,y)dydx = \int_1^{\infty}\Gamma\left(\dfrac{x-1}{x}\right)dx = \infty,$$
where $\Gamma$ is the Gamma function. The first inequality follows by using that you are integrating a positive function over a smaller domain. The following equality is obtained after some algebra (you can also use Mathematica if you don't believe in magic). The integrand is lower bounded by $1$, which implies the infite integral.
Perhaps there is a typo in your expression since you mentioned that it is trivial to show it is a density? It would be interesting to see the original source.

redpajama_set_name: RedPajamaStackExchange


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I've been working on a writing project and came across this article I wrote and published years ago. Below I have included a summarized version. It is about Father Bernard Lichtenberg who died at the hands of the Gestapo 72 years ago this month. I do not wish to add to all the heated rhetoric about ISIS, immigration, Syria, and the like (Those who know me well know that I abhor politics, so if you are looking to argue or fight, I'm not your guy). I repost this today as food for thought, knowing wee don't need more words on these matters as much as we need deep, thoughtful, meditation leading to loving, redemptive action.
It's strikes me as tragically ironic that all we have to do is substitute the name/group for today's controversy (Syrian refugee) for some other group from yesterday (Mexican, Black, Jap, Irish, Jew, Italian, Redskin/savage) to see that what is said today is recycled.
Considered "irredeemable," his appeal was granted. He was condemned and consigned to the concentration camp at Dachau. Aged, frail, and in a weakened state, Bernard Lichtenberg died while in transit November, 1943. Father Lichtenberg, almost single-handedly opposing the Nazis, was not acting in a sensible manner. He was not being practical. He was being loving. Such love can appear like madness, leading the follower of Jesus into all manner of impracticality in the "real world." But practicality doesn't seem to be Jesus' main concern.
We are instructed to love, following Jesus' own example, not because it is practical, reasonable, logical, or safe. An not for a minute should we think that unselfishly loving our neighbors will save the world from all hate and violence. Nor will it make our membership rolls at the church grow, achieve justice for all society, or make us popular. We love our neighbors as ourselves not because it always "works," but because it bears witness; it is a clear reflection of the love of God for all. These "opportunities," as Lichtenberg called them, to join the weak, abused, and mistreated aren't realistic; because love doesn't always "succeed," but it always shines as a light in the darkness.


Have You Heard? Facts From The Field is a weekly feature from the Office for State, Tribal, Local and Territorial Support to provide CDC and the field with facts and news from state, tribal, local and territorial public health agencies.
We sought to understand the experiences and perceptions of food producers regarding food procurement programs for local institutions. A total of 72 (45%) Mississippi fruit and vegetable growers completed a mailed survey, and of those that reported selling to local businesses and institutions (54%), few were selling to schools (13%). The primary motivations to sell to institutions were to increase profits (67%) and to improve nutrition within their communities (57%), while the most commonly reported barrier was a lack of knowledge about how to sell to institutions (39%). Farm to institution programs must develop evidence-based practices designed to address barriers to producers' participation in local institutional food procurement programs.
Looking for a speaker for an event within your school or community? These organizations help you find qualified presenters.


text:
Named after the David Cronenberg film, this is the blog of former RogerEbert.com editor Jim Emerson, where he has chronicled his enthusiasms and indulged his whims since 2005. Favorite subjects include evidence-based movie criticism, cinematic form and style, comedy, logical reasoning, language, journalism, technology, epistemology and fun. No topic is off-limits, but critical thinking is required.
Dogme 09.8 Manifesto: Ten limitations for better movies
by Jim Emerson
"The images that surround us today are worn out, they are abused and useless and exhausted. They are limping and dragging themselves behind the rest of our cultural evolution." -- Werner Herzog
Dogme 09.8 has the expressed goal of countering "certain tendencies" in the cinema today. In the spirit of Lars Von Trier's "The Five Obstructions," it acknowledges a fundamental truth -- that new constructive discipline is needed in filmmaking.
Dogme 09.8 is a rescue action!
In 1995 enough was enough. The movie was dead and called for resurrection. The goal was correct but the means were not! Dogme 95 proved to be a secondary ripple that washed ashore and turned to muck. Purity turned to laziness. Obstacles became crutches. Babies were thrown out with bathwater. It was fun but very silly, and the results, filtering into every aspect of filmmaking worldwide, have been counterproductive and deadening.
To Dogme 09.8, cinema is individual!
But individuality requires skill, judgement, discipline and taste (good or bad, just not hacky) in order to be effective on the screen. Hackwork is hackwork, whether it's accomplished with handheld video cameras or computerized motion-control. As never before, the superficial action and the superficial movie are receiving all the praise.
To Dogme 09.8 the movie is illusion!
Because movies are pure illusion! That is the stuff they are made of. There is no "documentary reality" -- unless, by that phrase, one means the illusory reality created by a film, including a so-called "nonfiction" or "verité" one. Stylistically, a Maysles documentary or a Cassavettes feature is every bit as much the product of aesthetic and technological artifice as a Michael Bay movie. Whether by employing obtrusive lo-fi technology, or the latest high technology, anyone at any time can make technology itself the subject of the film and wash away the last grains of cinematic illusion in the deadly embrace of sensation.
Dogme 09.8 celebrates the preservation of illusion, the visual integrity of Buster Keaton and the inventive wit of Ernst Lubitsch, by the presentation of a set of rules known as The Vow of Integrity:
1. Get a tripod. Learn how to use it. Human beings do not feel their heads bobbling around all the time. If they did, they'd throw up a lot more. The hand-held camera, once a legitimate tool, has been overused to death. It is beyond a cliché, beyond a "certain tendency" -- it has become the most obtrusive, commonplace annoyance in modern films, a hallmark of visual illiteracy. Audiences should throw things at the screen every time they notice handheld camerawork.
2. Location-recorded sound isn't the finished product. Don't stop there. Create a soundtrack that enhances the world of your movie. Most people think Ramin Bahrani's "Chop Shop" was recorded with "live" sound. It wasn't. It's nearly all created in the studio, densely layered and impeccably crafted to sound natural and spontaneous.
3. Shoot the movie so that it can be assembled in as few well-planned shots as possible. Every unnecessary cut is a colossal statement of failure. Each shot, and each cut, must have a reason to exist within the world of the film -- like words in a sentence, or sentences in a paragraph. Profligate cutting is wasteful and monotonous. It saps images of their energy and it too often disrupts the crucial rhythms of the interactions between the actors/characters. Remember Hitchcock's rules: Don't use your most powerful tools (cuts, camera movements, close-ups) until/unless they are necessary. In other words: Don't be a spendthrift with money shots.
4. No more than three consecutive shots should last less than one second apiece. Nothing undermines confidence and interest in a movie more transparently than a film that is too timid and skittish to allow itself to be seen. Hyperactivity is self-defeating. Allow the audience to meet the movie at least halfway.
5. If you can tell it's CGI, don't use it. If nobody will notice, go right ahead. If your monster or your spaceship or your location or your decapitation can't be created in camera or with analog effects (like matte paintings), don't assume you can fix it with CGI. If it violates the reality of the film -- no matter what it is -- don't show it.
6. Don't fall back on overused scenes, subjects, images and superficial action. These are the usual signs that a movie has gone slack, coasting on auto-pilot: car chases, gun fights, fist fights, makeout montages, segues using snippets of pop tunes that fade out just as they're getting started, 360-degree (+) spinning shots, drug deals, sad women eating ice cream, explosions, zzzzz zzzzzzzzzzz. Snort. Aren't there other, more interesting stories to tell, and more interesting ways to tell them?
7. Don't scramble chronology just to make dull material less linear. It doesn't help.
8. Know your genre and filmmaking conventions. You can't subvert them if you're not familiar with them. It's like jazz: You can't re-work the tune if you don't know the melody to begin with. You have to know which notes not to play, and which to play around.
9. Fit the format to the film. Your reasons for shooting on video, or 35 mm, flat or scope, should be apparent in the film itself. Take advantage of your chosen format.
10. Remember that every single thing in your movie reflects a decision. Even if it's an accident or an oversight, it's in there (or not) because you chose to put it there or leave it there. Or because you didn't notice it was there, which is essentially the same thing because somebody else will.
Thus is made the Vow of Integrity. Go forth. Make movies.
Got more suggestions for ways of restoring cinematic integrity?
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Roger Ebert became film critic of the Chicago Sun-Times in 1967. He is the only film critic with a star on Hollywood Walk of Fame and was named honorary life member of the Directors' Guild of America. He won the Lifetime Achievement Award of the Screenwriters' Guild, and honorary degrees from the American Film Institute and the University of Colorado at Boulder.
Chaz is the Publisher of RogerEbert.com and a regular contributor to the site, writing about film, festivals, politics, and life itself.
Matt Zoller Seitz is the Editor at Large of RogerEbert.com, TV critic for New York Magazine, the creator of many video essays about film history and style, a finalist for the Pulitzer Prize in criticism, and the author of The Wes Anderson Collection. His writing on film and TV has appeared in The New York Times, Salon, New York Press, The Star-Ledger and Dallas Observer. (Banner illustration by Max Dalton)


Are you really what you eat? Our goal is to uncover the precise mechanisms that link nutrition to organismal health and disease states at the cellular and molecular level. A particular focus in our lab is to understand how dietary perturbations affect the immune system and contribute to the risk of diseases that are associated with immune dysfunction such as cancer.
Cells respond and adapt to the signals that they receive from their environment. Environmental factors such as nutrients affect cellular states by altering cell state-specific gene expression or metabolic programs. My research group investigates the causal cellular and molecular mechanisms that link nutrition to organismal health and disease. For example, diets that lead to obesity, such as high fat diets are significant environmental risk factors that influence cancer incidence and progression in several tissues. Although the interactions between tumor cells and the immune system play a significant role in tumorigenesis, little is known about how dietary perturbations impact immunity against cancer. Our studies interrogate the functional consequences of diets on immune recognition and response pathways that play critical role in cancer immunity. By identifying the altered gene expression and metabolic programs in the immune system in response to dietary perturbations, our goal is to uncover mechanistic links that can be therapeutically exploited for the treatment of diseases associated with immune dysfunction such as cancer.
Haber, A. L. and Biton, M. and Rogel, N. and Herbst, R. H. and Shekhar, K. and Smillie, C. and Burgin, G. and Delorey, T. M. and Howitt, M. R. and Katz, Y. and Tirosh, I. and Beyaz, S. and Dionne, D. and Zhang, M. and Raychowdhury, R. and Garrett, W. S. and Rozenblatt-Rosen, O. and Shi, H. N. and Yilmaz, O. and Xavier, R. J. and Regev, A. (2017) A single-cell survey of the small intestinal epithelium. Nature, 551(7680) pp. 333-339.
Roper, J. and Tammela, T. and Cetinbas, N. M. and Akkad, A. and Roghanian, A. and Rickelt, S. and Almeqdadi, M. and Wu, K. and Oberli, M. A. and Sanchez-Rivera, F. and Park, Y. K. and Liang, X. and Eng, G. and Taylor, M. S. and Azimi, R. and Kedrin, D. and Neupane, R. and Beyaz, S. and Sicinska, E. T. and Suarez, Y. and Yoo, J. and Chen, L. and Zukerberg, L. and Katajisto, P. and Deshpande, V. and Bass, A. J. and Tsichlis, P. N. and Lees, J. and Langer, R. and Hynes, R. O. and Chen, J. and Bhutkar, A. and Jacks, T. and Yilmaz, O. H. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol, 35(6) pp. 569-576.
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Beyaz, S. and Yilmaz, O. H. (2016) Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-delta Pathway. Clin Cancer Res, 22(23) pp. 5636-5641.
Beyaz, S. and Mana, M. D. and Roper, J. and Kedrin, D. and Saadatpour, A. and Hong, S. J. and Bauer-Rowe, K. E. and Xifaras, M. E. and Akkad, A. and Arias, E. and Pinello, L. and Katz, Y. and Shinagare, S. and Abu-Remaileh, M. and Mihaylova, M. M. and Lamming, D. W. and Dogum, R. and Guo, G. and Bell, G. W. and Selig, M. and Nielsen, G. P. and Gupta, N. and Ferrone, C. R. and Deshpande, V. and Yuan, G. C. and Orkin, S. H. and Sabatini, D. M. and Yilmaz, O. H. (2016) High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature, 531(7592) pp. 53-8.
Das, P. P. and Hendrix, D. A. and Apostolou, E. and Buchner, A. H. and Canver, M. C. and Beyaz, S. and Ljuboja, D. and Kuintzle, R. and Kim, W. and Karnik, R. and Shao, Z. and Xie, H. and Xu, J. and De Los Angeles, A. and Zhang, Y. and Choe, J. and Jun, D. L. and Shen, X. and Gregory, R. I. and Daley, G. Q. and Meissner, A. and Kellis, M. and Hochedlinger, K. and Kim, J. and Orkin, S. H. (2015) PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep, 12(9) pp. 1456-70.
Das, P. P. and Shao, Z. and Beyaz, S. and Apostolou, E. and Pinello, L. and Angeles, A. L. and O'Brien, K. and Atsma, J. M. and Fujiwara, Y. and Nguyen, M. and Ljuboja, D. and Guo, G. and Woo, A. and Yuan, G. C. and Onder, T. and Daley, G. and Hochedlinger, K. and Kim, J. and Orkin, S. H. (2014) Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell, 53(1) pp. 32-48.
Haspot, F. and Li, H. W. and Lucas, C. L. and Fehr, T. and Beyaz, S. and Sykes, M. (2014) Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. Am J Transplant, 14(1) pp. 49-58.
Guo, G. and Luc, S. and Marco, E. and Lin, T. W. and Peng, C. and Kerenyi, M. A. and Beyaz, S. and Kim, W. and Xu, J. and Das, P. P. and Neff, T. and Zou, K. and Yuan, G. C. and Orkin, S. H. (2013) Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell, 13(4) pp. 492-505.
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Manchester Crown Court
Murdered paedophile suspect 'victimised'
A suspected paedophile murdered just weeks before he was due in court was victimised on the housing estate where he lived, his family said yesterday.
Teesside Live
George Crawford was found battered to death in his bungalow on the Kirkholt estate in Rochdale, Greater Manchester, on Friday evening.
Mr Crawford, 64, had been due to appear before Manchester Crown Court next month accused of indecently assaulting two young boys in the late 1970s and early 1980s.
His brother Roy Crawford yesterday told how the dead man had been the victim of verbal abuse since the news of his impending trial spread across the Kirkholt estate.
Retired textile worker Roy Crawford said: "George had basically locked himself away after all this started. He was terrified of being got at if he went outside.
"He had people shouting things at his house at all times of the day and night. It wasn't just kids, but adults as well.
"I don't know what they were shouting but it was stuff to do with the rumours and the court case.
"He was very nearly blind so there was not much he could do with himself. He liked a drink now and then but he couldn't really do that any more. He was scared."
Roy Crawford added that his brother, who lived with wife Brenda, had always protested his innocence.
"We didn't go into the details but he just said it was a pack of lies and he had no idea why the lads had picked on him," he said.
"He was not worried about the trial. He said he was looking forward to it for the chance to clear his name.
"I totally believed in him. He was my brother and if he said he didn't do it then that is good enough for me."
A spokesman for Greater Manchester Police said detectives were keeping 'an open mind' as to the killer's motive.
Staff at Kirkholt Working Men's Club, where Mr Crawford was a regular, said yesterday there were 'mixed feelings' about his death.
Stewardess Brenda Simmons said: "People are not talking much about it just yet but let's say there are mixed feelings here.
"There are some who think that only a court can decide whether someone is guilty and there are some who say if you're involved in that then you've got it coming."


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How tuberculosis fueled Colorado's growth
By Shanna Lewis
Tuberculosis was the top killer of Americans in the late 1800s and early 1900s. There was no cure at the time so health officials encouraged sufferers to leave behind stuffy cities and get some fresh air and sunshine. Colorado had plenty of both.
In a new PBS documentary, "The Forgotten Plague," which airs today, historian Sheila Rothman says TB patients came to get cured. "Come west and get life," she says. "It was a health giving Eden, this outdoors beautiful unsettled part of the country."
One of those who heard the call was History-Colorado president Ed Nichols' great grandfather, who came here from Manhattan in 1872 because of TB.
"He was told that if he wanted to live another year he had to get to a drier climate," she says. "He moved out to Colorado and actually ended up in Manitou Springs. He lived there and brought his family out a year later."
Sixty years later, Nichols' mother came to Colorado Springs to heal from TB. By one estimate, 60 percent of the state's population in 1925 came to Colorado because of TB.
This influx has had long-lasting impact, says University of Denver historian Jeanne Abrams. Many of Denver's hospitals started as sanatoriums -- the facilities designed to help TB patients. National Jewish Hospital and Swedish Medical Center are among these institutions, helping poor and indigent TB patients arriving in the state. And there were thousands of TB patients who needed help.
"Some East Coast aid groups were sending poor TB patients west with a basket of fruit and a one way ticket," Abrams says.
She says they came first by the hundreds, then by the thousands. She notes that although most people think that the main driver of population growth in Colorado was mining or ranching, it was actually TB patients coming for "the cure."
"They came for the health, not for the wealth," Abrams says. "Colorado became known as the World's Sanatorium."
A number of famous people came to Colorado because they or a family member had TB, including Israel's Golda Meir, poet Robert Frost, and Robert Speer who stayed and eventually became mayor of Denver. Doc Holladay, known for his involvement in the OK Corral shootout, came for TB treatment, too, and eventually died in Glenwood Springs.
TB affected all aspects of life during that era, says Abrams. Women raised their hemlines so their skirts wouldn't drag in the filth, men shaved their beards, so as not to carry germs in the hair, playgrounds became popular so that kids would get into the healthy outdoor air, and Kleenex was invented.
In the 1940s the right cocktail of antibiotics was finally discovered and TB deaths in the US and other countries declined dramatically. TB is still a major problem in the less developed world. It is estimated that one third of the world's population is infected with TB.


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Sterling is not concerned about the negative publicity over his choice of body art.
Raheem Sterling is focused on the World Cup after coming in for criticism over having a gun tattooed on his leg.
The 23-year-old has chosen to focus on England's preparations for Russia 2018 rather than negative publicity over his choice of body art.
Sterling's unfinished leg tattoo of a gun brought criticism from sections of the media at the start of last week, leading the Football Association to express its full support of a player who explained it was in tribute to his father after he was gunned down in Jamaica when the forward was just two.
There was further scrutiny after Sterling took a tumble in Saturday's friendly win against Nigeria – a match he was going to be dropped for having reported late for camp, only for manager Gareth Southgate to change his mind after the player came under attack for his tattoo.
Sterling said: "(This week) it's not really been that tough. Things happened and get spoken about, but I put that to one side. I've been focused on training and playing Nigeria, so for me it was a normal week to be honest.
"The only thing that changed was that I was in the newspapers a bit more. I just got on with my day. I spoke with my mum and she was OK. My daughter and my son are OK, I'm fine.
"That was the least of my worries. It's obviously bad to see yourself spoken of in that light, but it's not something that gets me down.
Sterling has, though, been aware of the widespread public support – backing that has not always been there.
"I heard that there was a lot of positives," Sterling, who referred to himself as 'The Hated One' at Euro 2016, said.
Sterling was peppered with questions during a 45-minute open media session at St George's Park, just days after England beat Nigeria 2-1 in their penultimate World Cup warm-up friendly.
Sterling may well get another chance to shine when England line up against Costa Rica at Elland Road in Leeds this Thursday.
A brief break follows the final friendly before an internal game and the squad jetting off to Russia on June 12.