text:
Pregnant Palestinian and child die in Israeli air raid
Noor Hassan, who was five-months pregnant, along with her three-year-old daughter, killed in air strike near Gaza City.
A Palestinian woman who was five-months pregnant and her three-year-old daughter have been killed in an Israeli air strike east of Gaza City.
Medical sources in the besieged territory said 30-year-old Noor Hassan and her daughter Rahaf died when their house collapsed following an Israeli air strike on a Hamas military training camp near their home.
Three other people were wounded in the attack on Sunday, and Palestinian rescue services are continuing to search under the rubble.
The Israeli army said the air strikes were launched in response to a rocket that was fired into southern Israel. The rocket was reportedly intercepted by Israel's Iron Dome rocket defence system.
The army said that its planes were targeting two Hamas weapons-manufacturing sites in the area.
After the deaths of the mother and child, Lieutenant Colonel Peter Lerner, an Israeli army spokesman, said: "The IDF [Israeli army] holds Hamas responsible for any act of aggression from the Gaza Strip."
Car 'explosive'
In a separate incident on Sunday, Israeli police said a Palestinian woman set off an explosive device in the occupied West Bank.
A policeman spotted her vehicle close to the Israeli settlement of Maale Adumim and ordered the 31-year-old woman to stop, police said.
She exited the car and the explosives inside detonated, police spokesman Micky Rosenfeld said, wounding her seriously and the officer lightly.
The woman, from Jericho in the West Bank, shouted "Allahu Akbar" (God is great) before the device went off. It was not clear whether she intended to carry out an attack at that location or elsewhere.
According to photos distributed by police, the explosives did not appear especially powerful, with the car still intact after the blast.
Teenagers killed
On Saturday, Israeli soldiers shot and killed two Palestinian teenagers in the Gaza Strip during confrontations, less than 24 hours after six people were shot dead while protesting along the border with Israel.
Palestinians targeted by 'surge' in settler violence
Analysis: Netanyahu 'better not disturb the status quo'
Stabbing linked to Israel's systematic violence
Analysis: Why Israel wants a religious war over al-Aqsa
The controversial killing of Fadi Alloun
Hebron in turmoil as unrest engulfs West Bank
The Palestinian Health Ministry said 13-year-old Marwan Barbakh and 15-year-old Omar Othman were shot with live ammunition in eastern Khan Younis in the southern Gaza Strip.
Medical sources confirmed to Al Jazeera that at least 23 people had been injured in clashes with Israelis across Gaza on Saturday.
The ministry said in a post on Facebook that the total number of Palestinians killed since the start of October now stood at 20, with nine killed in the Gaza Strip, and 11 in the occupied West Bank and occupied East Jerusalem.
The deaths of Noor Hassan and her daughter bring the death toll to 22.
On Friday, Israeli soldiers killed six Palestinians protesting along the border separating the territory from Israel.
Among those killed on Friday was a 15-year-old boy who was fatally shot at a demonstration in the al-Faraheen village, southeast of Gaza City.
The Israeli army claimed there had been "multiple violent attempts to storm the border fence" and "a thousand rioters infiltrated the buffer zone", throwing a "grenade, rocks and rolled burning tyres" at the soldiers".
IN PICTURES: Jerusalem unrest spills over to West Bank
East Jerusalem deaths
The deaths of the two teenagers in Gaza came shortly after three Palestinians were killed in separate incidents in East Jerusalem after reportedly attacking Israelis.
Frustration boiling over in occupied West Bank
The dead included a 16-year-old who was shot dead by Israeli police after stabbing two men, and a member of Hamas who opened fire on Israeli paramilitary police during a clash in the Shuafat refugee camp.
Another Palestinian was shot dead after a stabbing attack against Israeli police officers. The incident left three Israeli police officers injured, one seriously after a possible "friendly fire" incident.
A Palestinian who was shot by Israeli forces in Hebron on Thursday succumbed to his injuries two days later.
The Palestinian Ministry of Health said two Palestinians were being treated for head injuries in Bethlehem after being hit by tear gas canisters fired by Israelis during protests there.
Al-Aqsa tensions
The recent violence has been fuelled by Palestinian fears that Israeli hardliners are trying to take control of the al-Aqsa Mosque compound in East Jerusalem, one of Islam's holiest sites.
Those fears have grown after visits by Jewish groups, including politicians, to the site.
Israeli Prime Minister Benjamin Netanyahu has insisted Israel is committed to maintaining the status-quo and has banned his ministers from visiting the site.
Under the current arrangements, Jews are allowed to visit the site but non-Muslim prayer is banned.
Palestinians in Gaza have been protesting in solidarity with those in the West Bank [Ezz Zanoun/Al Jazeera]
Gaza: After the war


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text:
Q: Как реализовать свайп блока с помощью touchmove? Как реализовать плавное перетягивание пальцем блока main с помощью touchmove, зажимая line?
Начальное положение main bottom = 0, конечное положение bottom = -300px;.
Если по окончанию перетягивания значение bottom меньше (-100), то сразу присваивается значение (-300).

const line = document.querySelector('.line')
const main = document.querySelector('.main')
line.addEventListener('touchmove', () => {

})
line.addEventListener('touchend', () => {
  if (parseInt(main.style.bottom) < (-100)) main.style.bottom = -300 + 'px'
})
* {
  margin: 0;
  box-sizing: border-box;
}

.wrapper {
  display: grid;
  place-content: center;
  height: 100vh;
}

p {
  font-size: 16px;
  text-align: center;
  user-select: none;
}

.main {
  display: grid;
  place-content: center;
  width: 300px;
  height: 70vh;
  bottom: 0;
  background-color: aquamarine;
  position: relative;
  transition: transform 300ms ease;
}

.line {
  width: 200px;
  height: 15px;
  background-color: black;
  position: absolute;
  top: 5px;
  left: 50px;
  transition: opacity 600ms ease;
}

Попробуйте потащить

A: Сделал так.
Если есть нюансы, прошу, подметить их.

const line = document.querySelector('.line')
const main = document.querySelector('.main')
line.addEventListener('touchstart', (evt) => {
  main.style.removeProperty('transition');
  const firstTouch = evt.touches[0];
  y1 = firstTouch.clientY;
})

line.addEventListener('touchmove', (evt) => {
  const line = evt.target.querySelector('.line');
  if (!evt.target.closest('.line')) return;
  let y2 = evt.touches[0].clientY;
  let yDiff = y1 - y2;
  main.style.bottom = yDiff + 'px';
})

line.addEventListener('touchend', () => {
   main.style.transition = 'bottom 0.3s ease'
  if (parseInt(main.style.bottom) < (-150)) {
    main.style.bottom = -300 + 'px';
  } else {
    main.style.bottom = 0;
    }
})
* {
  margin: 0;
  box-sizing: border-box;
}

.wrapper {
  display: grid;
  place-content: center;
  height: 100vh;
}

p {
  font-size: 16px;
  text-align: center;
  user-select: none;
}

.main {
  display: grid;
  place-content: center;
  width: 300px;
  height: 70vh;
  bottom: 0;
  background-color: aquamarine;
  position: relative;
  transition: transform 300ms ease;
}

.line {
  width: 200px;
  height: 15px;
  background-color: black;
  position: absolute;
  top: 5px;
  left: 50px;
  transition: opacity 600ms ease;
}

Попробуйте потащить

redpajama_set_name: RedPajamaStackExchange


text:
Home » Industry News » Manufacturing » Green Bay Packaging To Build New "Super Plant" In Texas
Green Bay Packaging To Build New "Super Plant" In Texas
The manufacturing company's 600,000-square-foot corrugator plant will replace a smaller existing plant in Fort Worth, TX.
Green Bay Packaging Inc. (GBP) will begin construction of a new 600,000-square-foot corrugator plant in Fort Worth, TX. Construction on the site is set to begin in the first quarter of 2022 and startup operation is scheduled for the second quarter of 2023.
The new "super-plant" will replace GBP's existing 200,000-square-foot corrugator plant in Fort Worth. Wisconsin-based GBP has operated a plant in Fort Worth for more than 50 years. The new plant will be equipped with a new 110" Fosber corrugator and all new state-of-the-art high-speed flexo folder gluers and rotary die cutters.
"We are excited to continue to invest in our employees and customers of Ft. Worth," said Will Kress, President, and CEO of GBP. "The Fort Worth operation is an important part of GBP, and the leadership and employees of this division are second to none. We believe in investing in our people and our loyal customers, and we are looking forward to the next phase in Fort Worth."
The Fort Worth announcement is the latest step in GBP's continued growth and expansion. Over the last 12 months, GBP completed the startup and full production of the Green Bay Recycled Paper Mill; startup of a 550,000-square-foot box plant in Tulsa, OK; is in the process of a 370,000-square-foot expansion of its state-of-the-art Folding Carton operation; and is doubling the size of the newly acquired Third Dimension sheet plant in Geneva, OH. This is in addition to significant expansions of the company's Green Bay and Minneapolis box plants, and building a new sales, marketing and distribution center in Downers Grove, IL. GBP continues to install new high-speed converting and high-end graphic lines in multiple plants across the country.
"We are committed to this industry, our employees, and customers," said Bryan Hollenbach, Executive Vice President of GBP. "We continue to invest at a high level and work hard to make GBP a great place to work and build a career. It is a fun time to be working for GBP."
"We are fortunate to partner with customers that value the quality and service provided by our dedicated team in Fort Worth," added Rob Schroeder, VP/GM of GBP's Fort Worth division. "This new operation will unite the most modern equipment with our extremely talented employees to deliver a wide range of capabilities with the highest level of quality and service to our customers."
Want to learn more about Texas corporate expansion?
Considering Texas for your company's relocation or expansion project? Check out all the latest news related to Texas economic development, corporate relocation, corporate expansion and site selection.
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redpajama_set_name: RedPajamaCommonCrawl


I zipped through this, the third Harry Virdee novel, in just a matter of days. Around two and a half, I think. And, at 0232 hours this morning, I came to the end of this whirlwind paced, adrenaline fuelled, terrific bobby-dazzler of a read.
For such a clean cut, well presented, eloquent and charming chap, Mr Dhand writes the most frenetic, twisty and action-packed of crime thrillers. His books are dark and edgy and take the reader to the most desperate parts of Harry's Gotham, ad Mr Dhand's hometown of Bradford. If I was Mrs D, I'd keep an eye on him and maybe cut back on allowing him to have too many fizzy drinks.
I have had the great pleasure of attending several (well, more than several actually, watch out AA, stalker alert!!) literary occasions where the author has described his methods and ideas about crime thriller writing. At these events, he has also revealed some of the personal experiences which have shaped him as a man, as a husband and a father and which he has used as inspiration for his novels. It is, therefore, especially rewarding to read how he has woven these personal stories and memories into the lives of Harry, Ronnie and Saima.
It is partly thanks to this "personalisation" and attention to the little details, that lifts Harry Virdee, fully formed and lifelike off the page and bursting into the reader's head. It is also what helps elevate the series from being simply generic "cop chases bad guys" crime stories into something richer, fuller and, ultimately, hugely satisfying.
In addition to these glimpses into his own past, the other things that make these tales so fabulous to dive into are the plots themselves. On his book tours, Mr Dhand describes his desire to keep readers eagerly turning and devouring the pages by writing short chapters that propel the plot at a breakneck pace and to switch the action between the characters. Well, Mr D…with "City of Sinners", that's a big tick in that particular box. The author ratchets up the tension quickly – almost effortlessly – and keeps the reader enthralled and gripped right until the end.
One of the most pleasing aspects of the series has been the relationships between Harry and his family. Harry's wife, Saima, really comes into her own in this third book and we get to see much more of the woman Harry married, and whom he lost his family for. Always a significant character, especially in the dynamics between Harry and his father, the author has allowed Saima to develop into a truly appealing and absorbing central character. She has now blossomed and is becoming as forceful and dominant as Harry himself. Her presence and influence can be felt throughout the book.
One of the most rewarding things about a Virdee novel is the opportunity to spend time inside Harry's "Gotham" and to walk the dark streets of Bradford alongside our hero. As a regular visitor Bradford, and as someone with longstanding family connections to the area, I thoroughly enjoy Mr Dhand's gritty, yet passionate and compassionate, descriptions of the city. I get a lot of pleasure from recognising and being able to accurately envisage, the scenes that I am reading.
If you haven't yet wandered into the author's vision of Bradford yet, pick up book one, "Streets of Darkness" and let Mr Dhand guide you through them in the, relatively, safe company of Harry Virdee.
You'll enjoy the trip. You'll be scared, but you'll have a great time looking over your shoulder at the movements from the shadows.


text:
Der Traillauf (von  =  oder ; auch Trailrunning oder Waldlauf) ist eine Form des Langstreckenlaufs, die abseits asphaltierter Straßen stattfindet. Der Leichtathletik-Weltverband World Athletics erkannte den Traillauf 2015 als offizielle Disziplin an.

Überblick

Mit dem Begriff Traillauf (engl. Trail Running) lassen sich alle Ausprägungen des Laufens abseits von Straßen zusammenfassen, vom Jogging im Park auf ebenen Flächen bis hin zu Ultraläufen in mehreren Etappen über die Alpen.

Das Laufen auf Trails wird als besonders naturnah empfunden. Grober Untergrund und Hindernisse trainieren neben der körperlichen Ausdauer auch Koordinations- und Konzentrationsfähigkeit des Läufers. Da der gesamte Körper stabilisiert werden muss, werden mehr Muskelgruppen als beim Laufen auf der Straße beansprucht.

Typische Untergründe der Laufstrecken sind Schotter-, Wald- und Wiesenwege durch Wälder oder Parks, Singletrails, Stein- und Geröllpfade in alpinem Gelände, Trimm-dich-Pfade, Finnenbahnen oder Sand.

Gemeinsamkeiten und Unterschiede zu anderen Formen des Langstreckenlaufs
Eng verwandt mit dem Traillauf ist der Crosslauf, bei dem es ebenfalls darum geht, sich laufend durch profiliertes Gelände mit natürlichen Hindernissen zu bewegen. Allerdings werden Crossläufe in der Regel auf einem eigens abgesteckten Parcours von 1 bis 2 km absolviert, während für Trailläufe bereits vorhandene Wege und Pfade verwendet werden. Außerdem werden Trailläufe meist über längere Distanzen als Crossläufe durchgeführt, oftmals mit Streckenlängen, die auch im Bereich des Straßenlaufs populär sind (Halbmarathon, Marathon, 100 km usw.). In der Regel jedoch sind Trailläufe anders als Straßenläufe nicht offiziell vermessen, zum einen, weil das Gelände den Einsatz eines Jones-Counters nicht zulässt, zum anderen, weil durch das Profil der Strecke und die Bodenbeschaffenheit die erzielten Zeiten viel zu langsam sind, um für Bestenlisten herangezogen werden zu können. Einige wenige Straßenläufe jedoch führen teilweise über Trails. Beispiele dafür sind der Ho-Chi-Minh-Pfad bei den 100 km von Biel und der Egmond-Halbmarathon, der teilweise über einen Strand und Dünenwege verläuft.

Die allermeisten Bergläufe verlaufen auf Schotter-, Wiesen- und Geröllpfaden und können daher als eine Sonderform des Traillaufs angesehen werden.

Ähnlichkeiten bestehen auch mit dem außerhalb der Leichtathletik angesiedelten Orientierungslauf, bei dem ebenfalls die Anpassung an ständig wechselnde Bodenbeschaffenheit eine große Rolle spielt. Anders als beim Orientierungslauf ist jedoch bei Traillauf-Wettbewerben die Laufstrecke durch Markierungen vorgegeben, so dass vom Teilnehmer in dieser Hinsicht keine übermäßige Konzentration erforderlich ist.

Abzugrenzen ist der Traillauf auch gegen eine Form des städtisch-modernen Hindernislaufs, für den sich als Gattungsbegriff die Bezeichnung "Obstacle Race" oder Extremhindernislauf zu etablieren scheint, der aber häufig einen spezifischen Veranstalternamen trägt, z. B. StrongmanRun. Es handelt sich dabei meist um eine Laufveranstaltung im Freien, mit Streckenlängen üblicherweise zwischen ca. 5 km und 20 km, auf der in unregelmäßigen Abständen eine Vielzahl von natürlichen und eigens angelegten Hindernissen von den Teilnehmern zu bewältigen ist. Die Hindernisse haben dabei überwiegend einen urbanen und nicht-natürlichen Charakter durch die Verwendung von Schrottwagen, Autoreifen, Netzen, Containern, Treppen, Paletten, Sand- oder Schlamm etc.

Charakterisierung und Kategorisierung

Cross-Running (Urban Trail Running/Citytrail)
Die wohl einfachste und häufigste Form des Traillaufs findet auf Schotter-, Wiesen- oder Waldböden ohne größere Hindernisse statt. Viele Läufer starten am liebsten direkt von Zuhause aus und legen daher oft eine gewisse Strecke auf Asphalt zurück, bevor sie dann auf ihre Standardrunde im Wald oder Stadtpark einbiegen. Oftmals werden auf landschaftlich reizvollen Strecken dieser Art mit wechselndem Untergrund Volksläufe veranstaltet.

Cross-Trail (On Trail)
Beim Cross-Trail läuft man ausschließlich abseits asphaltierter Straßen, oft in schwierigerem Gelände mit Steigung und Gefälle (s. Berglauf), ohne dabei jedoch die vorhandenen Wege und Trampelpfade zu verlassen.

Trail-Adventure (Off Trail)
Adventure umschreibt die wohl extremste, sportlich anspruchsvollste Ausprägung des Traillaufs.
Viele suchen das Abenteuer im alpinen Gelände oder abseits befestigter Wege. Der Untergrund (Stein, Geröll, Fels…) erfordert maximale Aufmerksamkeit, und oft müssen extreme Steigungen bzw. Gefälle und teilweise sogar natürliche Hindernisse (Bäume, Äste, Bäche…) überwunden werden.

Ultralauf
Als Ultratrails bzw. Ultraläufe werden Läufe bezeichnet, die länger als die Marathondistanz sind, siehe Ultramarathon.

Ausrüstung
Die beim Traillauf nötige Ausrüstung hängt sehr stark von der Schwierigkeit des Geländes, von der Witterung und von der Dauer des Laufes ab. Schuhe für einfaches Gelände (Urban Trail Running) benötigen nur geringfügig mehr Grip und Stabilität als Straßenlaufschuhe.
Schwierigeres Gelände stellt jedoch größere Anforderungen. Dabei werden neben einem guten Profil und guter Stabilität oft auch ein niedriger Schwerpunkt, möglichst geringes Gewicht, Robustheit und Witterungsschutz als wichtig angesehen. Der niedrige Schwerpunkt wirkt sich positiv auf die Stabilität aus und das Gewicht der Schuhe beeinflusst den Sauerstoffverbrauch des Läufers, 100 g an jedem Fuß erhöht den Sauerstoffverbrauch um ca. ein Prozent.
Der Schuh sollte hinsichtlich Dämpfung und Steifigkeit sowohl dem Laufstil des Läufers, als auch dem Gelände angepasst sein. Außerdem muss der Schuh den Fuß vor dem Untergrund, wie etwa scharfen Steinen, schützen.

Die Laufkleidung ist atmungsaktiv und leicht. Für längere Touren werden oft Laufrucksäcke mit wichtigem Gepäck wie Wasser, Essen, Kompass und Karte, Stirnlampe, wetterfeste Kleidung, Mobiltelefon, Erste-Hilfe-Set und Rettungsdecke mitgenommen. Das Wasser wird meistens entweder in einer Flasche in der Hand gehalten, oder per Trinksystem im Rucksack, bzw. in einem Trinkgürtel mitgenommen. Bei vielen längeren Veranstaltungen sind einige dieser Ausrüstungsgegenstände Pflicht. Darüber hinaus verwenden einige Läufer leichte Trekkingstöcke, um die Beinmuskulatur zu unterstützen.

Veranstaltungen

Die wohl populärste Trailveranstaltung in Deutschland ist der GutsMuths-Rennsteiglauf, der seit 1973 stattfindet. Er besteht aus einem Supermarathon von 72,7 km, einem Marathon von 43,5 km und einem Halbmarathon. Der anspruchsvollste Lauf in Österreich ist mit rund 95 km und ca. 6500 Höhenmetern der Pitztal-Gletscher Trail-Maniak.

Seit 2001 richtet die Deutsche Ultramarathon-Vereinigung (DUV) Deutsche Meisterschaften im Ultratrail aus (bis 2011: Deutsche Meisterschaften im Cross- und Landschaftslauf). 2007 wurde von der International Association of Ultrarunners (IAU) die World Trail Challenge ins Leben gerufen, später umbenannt in IAU Trail World Championships.

Einer der anspruchsvollsten Trailläufe weltweit ist der Ultra-Trail du Mont-Blanc (UTMB), der mit einer Streckenlänge von ca. 168 km, mehr als 9000 zu überwindenden Höhenmetern und einem Zeitlimit von 46 Stunden um das Mont-Blanc-Massiv führt. Ebenfalls in hochalpines Gelände führt der Transalpine-Run, ein Etappenlauf, bei dem Zweierteams in acht Tagen 260 km und 15.000 Höhenmeter bewältigen. Der älteste Traillauf in den Vereinigten Staaten ist das Dipsea Race, das – mit Unterbrechungen – seit 1905 in Mill Valley, Kalifornien, ausgetragen wird. Immer beliebter werden auch kleine familiäre Läufe wie etwa der Bilstein-Marathon.

Mittlerweile gibt es auch Laufcups, die Serien von Trailläufen umfassen, z. B. die Ultra-Trail World Tour, für die 12 Veranstaltungen weltweit gewertet werden (darunter der UTMB), den Europacup der Ultramarathons oder die Skyrunning-Serie. Für Deutschland ist z. B. der Active Trailrunning-Cup mit sechs Läufen in Ostwestfalen-Lippe zu nennen.

Literatur
 John Foden: A Guide to Organising Trail Races. With Some Hints for Competitors. Trail Running Association, 2001 (PDF; 1,27 MB)

Weblinks

Fußnoten

International Association of Ultrarunners
Langstreckenlauf
Natursportart

redpajama_set_name: RedPajamaWikipedia


At LeafCann we are striving to become one of Australia's first triple P (People, Planet, Profit) medical cannabis growers and producers. Our primary focus will be to provide high quality, organic cannabis products as a readily available natural alternative for patients across Australia.
If you're interested in using LeafCann's natural alternative medical cannabis products, please fill in the form to help us build an evidence base and support for the LeafCann project.


Technip Oceania (TPO), a Technip Group operating centre in Perth, Australia, has been awarded a contract, worth approximately AUD110 million (€90 million), by Daewoo Shipbuilding and Marine Engineering (DSME) for the detailed design of Chevron's Wheatstone offshore gas processing platform, located 200 kilometers off Western Australia's coast.
The upstream (offshore) portion of the project is comprised of the development of gas fields in the WA-17-R and WA-253-P petroleum titles located on the Northwest Shelf offshore Western Australia at water depths of 70 to 200 meters. Subsea gas-gathering systems will transport production to the processing platform where the gas and condensate will be treated. It will then be exported to the onshore gas plant located at Ashburton North, 12 kilometers west of Onslow, on the Pilbara coast of mainland Western Australia.
DSME's Project Manager, KH Lee says "it has been good to be able to use Technip's Australian office to lead this work. The continuation from FEED, the knowledge of Australian requirements, and the proximity to Chevron gives us a great advantage." Technip's operating centers in Perth, Australia and Kuala Lumpur, Malaysia will execute the contract, which is scheduled to be completed in the second half of 2012.


Disinhibitory actions of the GABAA agonist muscimol in immature hippocampus.
Bath application of muscimol (10-20 microM) to hippocampal slices obtained from rats on postnatal days 10-15 produced epileptiform activity in the form of multiple population spikes in 20% of slices tested, concurrent with marked disinhibition. The disinhibition occurred in nearly 100% of cases tested at muscimol concentrations that produced epileptiform activity. Paired pulse analysis of GABAergic recurrent inhibition revealed a muscimol-induced disinhibitory effect involving a decrease in maximum possible inhibition. Spontaneous and antidromically elicited inhibitory postsynaptic potentials (IPSPs) recorded intracellularly were suppressed by muscimol. Current-voltage analysis of the recurrent IPSPs suggests that muscimol acted at a number of sites to produce disinhibition. The input conductance of the postsynaptic pyramidal cell increased due to muscimol, creating a current shunt which likely decreased the efficacy of synaptic currents. Muscimol also caused a decrease in the conductance due to the IPSP as well as a shift in the depolarizing direction of the equilibrium potential of the IPSP. The data indicate that muscimol, a GABAA agonist, can produce disinhibition resulting from the multiple consequences of its action. We conclude that the physiologic consequences of GABAA agonist treatment are complex. On the other hand, neurons are likely to be inhibited by a tonic increase in membrane conductance. However, since recurrent inhibition is simultaneously compromised, excitatory vollies of sufficient intensity may overcome the tonic inhibition and produce a hyperexcitable state. In some cases, this disinhibition may induce epileptiform activity. These observations are relevant in light of the proposed use of GABA agonists clinically to control seizures.


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Luke Rowe "gutted" at Tour of Flanders disqualification (+ video)
by Simon MacMichael April 1 2018
Team Sky rider ejected from race after taking to bike path and weaving through spectators
Team Sky's Luke Rowe has said he is "gutted" at his disqualification from the Tour of Flanders today when he rode on along a bike path with around 56 kilometres remaining of the race, saying he was forced to do so to avoid crashing.
The Welsh rider, who returned to racing last month after breaking his leg in more than 20 places in August, was ordered out of today's race by commissaires after taking to the cycle path where he had to weave through spectators before rejoining the road.
The Tour of Flanders confirmed on Twitter that he Rowe had been told to depart the race, with Team Sky saying on the same social network that it "looked like he got caught out by spectators while trying to move up ahead of the Kwaremont."
Rowe posted a statement to Twitter following the race, which was won by Niki Terpstra of Quick Step Floors.
Gutted about today, here's my side of it ... 1 week to go #Roubaix pic.twitter.com/NeQlYigppT
— Luke Rowe (@LukeRowe1990) 1 April 2018
With the race jury having warned riders beforehand to stay off roadside bike paths, some had little sympathy for him, however.
Do not agree, this shows that you had plenty of room and time to make another decision - at the cost of positions, the rules are interpreted fine on this. The rules are harsh and not followed through equally, but this is a valid DQ. pic.twitter.com/VQLtxBbgEA
— René (@RenAigu) April 1, 2018
Luke Rowe
Tour of Flanders 2018
Simon MacMichael
Simon has been news editor at road.cc since 2009, reporting on 10 editions and counting of pro cycling's biggest races such as the Tour de France, stories on issues including infrastructure and campaigning, and interviewing some of the biggest names in cycling. A law and languages graduate, published translator and former retail analyst, his background has proved invaluable in reporting on issues as diverse as cycling-related court cases, anti-doping investigations, and the bike industry. He splits his time between London and Cambridge, and loves taking his miniature schnauzer Elodie on adventures in the basket of her Elephant Bike.
grOg 1 hour 35 min ago
Xenophon2 1 hour 40 min ago


For the 10th consecutive year, Angelo State University has been listed by The Princeton Review as one of the country's best institutions for undergraduate education.
For the 10th consecutive year, Angelo State University has been listed by The Princeton Review as one of the country's best institutions for undergraduate education, an honor that goes to only about 15 percent of the nation's more than 2,500 four-year colleges.
The education services company features Angelo State in the 2019 edition of its annual college guide, "The Best 384 Colleges," published Aug. 7 by Random House. The guide is The Princeton Review's (TPR) flagship publication and includes detailed profiles of the colleges with rating scores for all schools in eight areas, based on surveys of 138,000 students nationally.
ASU is one of 13 Texas institutions and one of only five Texas public universities to make the 2019 "Best Colleges" list.
TPR also listed Angelo State among the "Great Schools" for two of the top 20 most popular undergraduate majors, agriculture and nursing. On a scale of 60-99, ASU also received a Quality of Life Rating of 91 and a Fire Safety Rating of 96.
In addition to making The Princeton Review's list of "The Best 384 Colleges," ASU was among the institutions in 15 western states listed in TPR's "Best Western" website feature.


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Best Silos & Smokestacks Partner Sites To Visit This Fall!
It's Fall In Iowa! That means hayrack rides, harvest festivals, and pumpkin patches! It also means the leaves they are a changin' & we have a colorful list of Silos & Smokestacks National Heritage Area Partner Sites to visit and Get Your Fall on!
Wagaman Mill & Museum
Scott Fairbairn
Wagaman Mill was built in 1846 by John R. Sparks as a paddle wheel saw mill on the North Skunk River. In 1848, the mill was converted into a grist mill with the construction of a wooden dam across the river. The 1868 addition of a hydraulic turbine allowed for year-long operation and the mill has since been utilized to produce flour, animal feed, meal and electric power.
Wickiup Hill Outdoor Learning Center
Fall Wetland courtesy of Frank Olsen
After an initial acquisition in the early 1960's, the area known as the Wickiup Hill Nature Area has grown to 751 acres of wetland, prairie, woodland, and savanna. Along with the Wickiup Hill Outdoor Learning Center, this area features 8 miles of educational and hiking trails.
Random Voyager / Via randomvoyager.com
A renovated 1932 dairy barn houses the visitor center, where maple syruping, beekeeping, prairie restoration, and other programs are used to interpret the natural environment and our cultural and agricultural heritage. The Indian Creek Nature Center has several miles of trails that wind through prairies, oak/hickory savannas and a wetland.
Cedar Valley Arboretum & Botanic Gardens
The Cedar Valley Arboretum and Botanic Gardens is a 35 acre green space for the Cedar Valley. Among our more formal gardens, we currently feature a prairie and we are also planning a butterfly meadow and an orchard featuring native fruit trees.
The Cascade Historic Limestone Silo & Agricultural Interpretive Center
The cornerstone of the Cascade Historic Limestone Silo & Agricultural Interpretive Center is the interpretation of the early Midwestern farmers and farmsteads displayed in the historic limestone silo built in the early 1930's. Antique agricultural equipment, in addition to interpretive signage, provide visitors knowledge of how early farmers worked the lands, used the local natural resources and helped support the economy of America.
Explore your world at the University of Iowa Museum of Natural History–Iowa's gateway to the global environment. Take a trip back in time through 500 million years of our natural and cultural heritage, culminating in the landscape we live on today and the story of agriculture from the first Native American farmers through to modern day Iowa.
Herbert Hoover Presidential Library & Museum
Learn about Iowa's only president at the Herbert Hoover Presidential Library & Museum. Hoover campaigned on the platform to restore prosperity to American farmers. His first action as President was to call a special session of Congress to pass the Agricultural Marketing Act of 1929. The Museum is one of the thirteen such institutions operated by the National Archives and Records Administration.
Living History Farms
Living History Farms / Via lhf.org
At Living History Farms you can travel at your own pace through 300 years of agricultural history, including a 1700 Ioway Indian Farm, 1850 Pioneer Farm, 1900 Farm and 1875 Town. On-site interpreters, activities and demonstrations.
Effigy Mounds National Monument
Effigy Mounds National Monument covers over 2,500 acres and protects more than 200 American Indian mounds. The monument's 14 miles of hiking trails will take you past the ancient mounds, through wooded bluffs and tallgrass prairies to scenic overlooks of the Upper Mississippi River Valley.
Fontana Interpretive Nature Center
Danny Murphy of Hazleton, IA
Discover the links between agriculture and environment at Fontana Interpretive Nature Center. A full service visitor center with displays that demonstrate how people make their home in a living environment. Programs are available upon request.
Brucemore
Brucemore's 26-acre, park-like estate invites exploration of its history, gardens, grounds, and 21-room Mansion. Each season, nature's changing beauty entices visitors to the estate offering new experiences. Concerts, theater, festivals, garden walks, holiday celebrations, and tours enliven the site and celebrate the heritage of the community.
Reiman Gardens
Reiman Gardens / Via iastate.app.box.com
Since 1914, a "garden laboratory" has been an essential teaching tool at Iowa State University. Today, the 17-acre Reiman Gardens incorporates academic and practical concepts with lessons from crop rotation to floriculture, entomology to water resource management. Inspiring future generations as environmental stewards is accomplished with tours, classes, lectures, articles and videos enjoyed by youth, students and 100,000 visitors annually.
Calkins Nature Area
Calkins Nature Area includes timber, prairie, stream, pond, Iowa River, American Indian/Natural History Museum and live native animal displays.
F.W. Kent Park
Travel Iowa / Via traveliowa.com
F.W. Kent Park is 1,052-acres that features a Conservation Education Center with hands-on exhibits that connect visitors with nature. Panels in the open-air Knight Prairie Pavilion interpret the connection of prairies to agriculture. An 86-site campground, shower house, playgrounds, picnic shelters, trails, eight historic bridges, fishing pier, native and re-created prairies, forests, wetlands, 27-acre lake, beach and fishing ponds, make this an outstanding park.
Four Mounds Inn Bed & Breakfast
The Four Mounds Estate, a National Register Historic District and a City of Dubuque Landmark Site, is a remarkably intact 1908 gentleman's farm along the Mississippi River bluff line. The site features the farm and grounds, river view hiking trails, three options for bed and breakfast, a small conference center, challenge ropes course and more. Includes whole house rentals and is the perfect site for an intimate wedding.
Hurstville Interpretive Center
Explore the links between Iowa's prairies, wetlands, the rocks beneath your feet and agriculture at Hurstville Interpretive Center. A butterfly garden and a working bee hive allow visitors to see pollinators at work. Exhibits help visitors understand how Iowa's early communities, such as Hurstville, developed around the resources that were available and were a focal point for farm families.
Hartman Reserve Nature Center
This over 300-acre wooded isle boasts the Hartman Reserve Nature Center and six miles of trails leading to lakes, prairies, forest, the Cedar River and the American Discovery Trail.
Scenic City Empress Boat Club
The Scenic City Empress Boat Club, a 1937 log cabin, is situated on the Iowa River and is home to the Empress Riverboat. Come enjoy our public cruises or book a private event. Soak in the beautiful scenery of the limestone bluffs, while listening to our captain's monologue. From agriculture to industry you will be entertained by our Iowa River interpretation! The Boat Club may be shut down for the season, but you can get a great view from the trails along the river!
Mines of Spain
Foggy Morning at Catfish Creek by Ronald W. Tigges / Via minesofspain.org
The Mines of Spain consists of 1,439 acres of forest and prairie along the Mississippi River. The park is a National Historic Landmark and a state preserve. The E.B. Lyons Interpretive Center, a Scenic Byway Center, has displays on the park's historical sites of farming, prairies, lead mining, Native Americans and wildlife. Trails connect visitors to a farmsite, forests, prairies, archaeological sites and wetlands.
Heritage Farm, the headquarters of Seed Savers Exchange, is an 890-acre living museum of our garden heritage. Display gardens surrounding the Visitors Center grow hundreds of heirloom fruits and vegetables, while eight miles of hiking trails connect sparkling trout streams, wooded bluffs, heritage poultry, Ancient White Park cattle, and 2 historic apple orchards.
Harpers Ferry, IA
Wickiup Hill Learning Center and Area
10260 Morris Hill Road
Toddville, IA
Wagaman Mill and Museum
200 East St
Lynnville, IA
Ushers Ferry Historic Village
5925 Seminole Valley Trl NE
3094 N Winn Rd
Decorah, IA
Iowa Falls, IA
Reiman Gardens – Iowa State Universtiy
1407 University Blvd
11121 Hickman Rd
Urbandale, IA
18670 63rd St
Maquoketa, IA
Herbert Hoover Presidential Museum
210 Parkside Dr
657 Reserve Dr
2048 Hwy 6 NW
Oxford, IA
319-645-2315 (Park Office) or 319-645-1011 (Conservation Education Center)
1883 125th St.
Hazleton, IA
1927 East Orange Rd
215 Pierce St SW
Cascade, IA
18335 135th St
2160 Linden Dr SE


A relative in the Caribbean asked me to send them some tomato seeds. Normally, I could find them in Big Lots and Walmart for $0.10 a pack but it is currently out of season.
Looking for a mail order web site that has similar pricing and low shipping prices.
the clearance rack at the hardward store?
How about fresh ripe tomatoes???
Remove, rinse and dry your own.
(1) If you plant tomatoes yourself, you can save the leftover seeds for several years, so you should have a ready supply to share. I have had 10 year old tomato seeds sprout with better than 50% germination.
(2) Tomato seeds are easy to extract from tomatoes. Take out the seeds and place in water for a few days. They will ferment a bit. Scrape off the gunk and spread the seeds on a piece of paper to dry. You can eat the tomato that's left over from this operation. The only disadvantage to this is that if you start with a hybrid tomato, you may not get the same thing when you grow the plant from the seeds (although it will most likely be similar, and almost certainly edible).
(3) Buying cheap seeds is counterproductive. They're cheap for a reason. Ten cent packages probably have lower germination rates than fresh seeds, although tomatoes have less of this problem than other vegetables. Also, the postage to send the seeds to the caribbean will far exceed the cost of cheap seeds, so you can afford to spend a bit more on the seeds. You can share a packet of fresh seeds.
(4) If your relative wants only a couple of tomato plants, a cheap seed packet would probably work, but when planting any vegetable it's best to select the seeds on the basis of the resulting fruit, not the price of the packet. If your relative wants a lot of plants it would be better to start with fresh seed to ensure better productivity.
My relative was thinking about planting several acres of tomatoes and therefore didn't want to spend a lot on seeds and was seeking the cheapest source possible. Ideally if I could locate 50 or so of those $0.10 packs normally sold in Walmart during the summer and put them into one container for him and mailed, it would be incredibly cheap.
I understand that cheap seeds have lower germination rates. This is ok. The idea was to take part of the seeds and plant on unused land and use the profits for charitable purposes. Planting tomatoes would also create temporary jobs that are sorely needed.
Did you seee this from SeedFreak?
Looks like flowers only, sorry!
Cindi, I suggest you check out this site and see if they have tropically suited tomato seeds. Otherwise search net for heirloom seeds. Cheap is just that. Your friend won't appreciate getting crap. JMHO.
When do you start tomato seeds/when do you set them outdoors?
Q : how late can I plant tomato seeds?
Tomato seeds, supermarket or packet?
Tomato seedlings, source on SF East Bay's I80 corridor (Berkeley to Milpitas)?
any good source of seeds for tomatoes.


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Q: Making a 'flip-book' type animation using density plots from R I'm new to R, but have worked out how to graph the distribution of my students' grades for a given term using a density plot, and have made some ridgeline plots to show how the distribution evolves throughout the academic year.
I'm thinking it might be fun (and make the graphs easier to interpret) if I could make a kind of flip-book animation that went from one terms grades to the next, relatively quickly, to see how the distribution changes.  At its simplest, I could just pop these distribution plots into Powerpoint and just scroll through the pages, but I'm wondering what commands I need to put into R's ggplot command to ensure that the axes/scaling from one chart to the next stays consistent from one chart to the next?
At the moment, I'm just making a simple chart using this command, where HT102 is the data from the 2nd term of Year 10, and A8 is a vector containing all the (numeric) grades.  I am then doing the same thing with another set of grades called ht103, and so on...
ggplot(ht102, aes(x = A8)) +
         geom_density(alpha=.3)

What would you recommend to keep the scaling consistent, and any thoughts on a better way to animate this than just popping them into powerpoint?


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When I awoke this morning, I had no idea this would be "the day." Following my usual routine and clad in my robe, I turned on the coffee maker before escorting Gus to the backyard where he sniffed awhile before lifting his right hind leg for a long pee against the fence. While he finished that business, I went through the garage and onto the driveway to retrieve the morning newspaper.
Even in San Diego where seasons are indiscernible for most folks, I sensed a feeling of "acorn fever" and the transition from summer to fall. It is a feeling that triggers in me a myriad of feelings and even actions. I'd first seen the term "acorn fever" in a San Diego Union column by Michael Grant, a much better writer than the Union was a newspaper at that time maybe 25 years ago – and there was no question I contract the mysterious malady at some point every year between late September and the arrival of the Trick or Treaters.
In addition to the feeling of a change, I invariably begin thinking and acting differently. How else to explain the fact that for the first time in months and instead of shorts I put on a pair of jeans, added a flannel shirt and told Andrea of my urge to crock pot a big roast along with some potatoes, carrots, onions and parsnips?
I am not alone in my reaction to the arrival of "the day." My dear old and sadly departed friend Bart lived in locales where winter would be just around the corner and although he regularly cut and gathered firewood throughout the summer, he turned into a monster in the world of firewood collection with the arrival of "the day," and it lasted until the arrival of the first snows of winter.
Not seeing much snow on the beaches of San Diego in the winter, my symptoms of acorn fever manifest themselves in different ways. In addition to the aforementioned wearing of long pants, flannel shirts and the preparation of comfort foods I begin to yearn for opportunities to hunt during the day and read books by a fire in the evenings. As the days shorten, I begin collecting books with the fervor of a squirrel gathering nuts before winter. Some days I even yield to the temptation to write.
Such moments are typically accompanied by an appropriate adult beverage such as the glass of Port that beckons and now sits before me, not quite half empty and certainly more than half full.
"Acorn Fever" I like that!! I guess I have it too as Fall is my favorite time of year!


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Culture, Ecommerce, Social
Amazon Launches AmazonFresh for Food Take-Out and Delivery Service
Amazon's restaurant takeout and delivery services to rival companies like Seamless, Grubhub and DeliveryHero, has finally become functional. The service will be an additional feature on the Amazon Local app and website, as according to a report published by Techcrunch.
The Takeout & Delivery feature was turned on over last weekend, and is currently functional in Seattle, covering around 20 restaurants for delivery and around 110 for take out orders that you need to pick up yourself, as per the same above mentioned source.
Amazon already has a hold on e-commerce sector and along with it, it seems like it wants to have a strong hold on offline market as well.
Amazon Fresh, the new service launched by the company has door delivery of groceries to a wide range of products from neighborhood shops and restaurants.
Also read : Amazon Launches a Credit Card Reader to Compete with Square and Paypal
In recent past, Amazon had launched a new service Amazon Local Register to expand its presence in the physical world. It will help small and mid-sized businesses to quickly and easily accept card payments with the help of card reader device by plugging it into headphone jack of smartphones or tablets.
Besides creating its own devices for consumers and businesses, Amazon appears to be trying to tap into every possible stream in e-commerce. Although most of its new products are still restricted in the US, the tech company seems to be testing the waters there before taking its services globally.
Tags: Amazonamazon freshamazon local register
By Bhavna Singh
Bhavna is a Post-Graduate in Mass Communication from Jamia Millia Islamia. She worked as a startup analyst at iamwire. She is a national level rifle shooter and is also passionate about horse riding.
View all articles by Bhavna Singh
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CRISPR 基因编辑
Clustered Regularly Interspaced Short Palindromic Repeats
Repetitive DNA sequences, called CRISPR, were observed in bacteria with spacer DNA sequences in between the repeats that exactly match viral sequences. It was subsequently discovered that bacteria transcribe these DNA elements to RNA upon viral infection. The RNA guides a nuclease (a protein that cleaves DNA) to the viral DNA to cut it, providing protection against the virus. The nucleases are named Cas, for CRISPR-associated.
In 2012, researchers demonstrated that RNAs could be constructed to guide a Cas nuclease (Cas9 was the first used) to any DNA sequence. The so-called guide RNA can also be made so that it will be specific to only that one sequence, improving the chances that the DNA will be cut at that site and nowhere else in the genome. Further testing revealed that the system works quite well in all types of cells, including human cells.
With CRISPR/Cas, it's easy to disrupt a targeted gene, or, if a DNA template is added to the mix, insert a new sequence at the precise spot desired. The method has profoundly changed biomedical research, as it greatly reduces the time and expense of developing animal models with specific genomic changes. Scientists now routinely use the CRISPR/Cas system for this purpose in mice. And for human diseases with a known mutation, such as cystic fibrosis, it's theoretically possible to insert DNA that corrects the mutation. There are clinical applications in human trials now, including for engineering T cells outside of the body for CAR-T cancer therapy and for editing retinal cells for leber's congenital amaurosis 10, an inherited form of blindness.
CRISPR/Cas is an extremely powerful tool, but it has important limitations. It is:
difficult to deliver the CRISPR/Cas material to mature cells in large numbers, which remains a problem for many clinical applications. Viral vectors are the most common delivery method.
not 100% efficient, so even the cells that take in CRISPR/Cas may not have genome editing activity.
not 100% accurate, and "off-target" edits, while rare, may have severe consequences, particularly in clinical applications.
In addition to editing somatic cells (the cells that make up most of the body), it's possible to edit the genomes of gametes (eggs and sperm) and early embryos, called germline editing. Any such edits in humans would not only affect an individual but also his or her progeny. They could also theoretically be used to enhance desirable traits instead of curing disease. Scientists have therefore called for a moratorium on human germline editing until the serious ethical and societal implications are more fully understood.
CRISPR是存在于细菌中的一种基因,该类基因组中含有曾经攻击过该细菌的病毒的基因片段。细菌透过这些基因片段来侦测并抵抗相同病毒的攻击,并摧毁其DNA。这类基因组是细菌免疫系统的关键组成部分。透过这些基因组,人类可以准确且有效地编辑生命体内的部分基因,也就是CRISPR/Cas基因编辑技术。
CRISPR/Cas系统是目前发现存在于多数细菌与绝大多数的古菌中的一种后天免疫系统,以消灭外来的质粒或者噬菌体,并在自身基因组中留下外来基因片段作为"记忆"。CRISPR的全称是Clustered Regularly Interspaced Short Palindromic Repeats。目前已发现三种不同类型的CRISPR/Cas系统,存在于大约40%和90%已定序的细菌和古菌中。其中第二型的组成较为简单,以Cas9蛋白以及向导RNA(gRNA)为核心的组成。Cas9是第一个被广泛应用的CRISPR核酸酶,其次是Cpf1,其在新泽西弗朗西斯菌的CRISPR/Cpf1系统中被发现。
由于其对DNA干扰的特性,目前被积极地应用于遗传工程中,作为基因体剪辑工具,与锌指核酸酶(ZFN)及类转录活化因子核酸酶(TALEN)同样利用非同源性末端接合(NHEJ)的机制,于基因体中产生DNA的双链断裂以利剪辑。第二型 CRISPR/Cas经由遗传工程的改造应用于哺乳类细胞及斑马鱼的基因体剪辑。其设计简单以及操作容易的特性为最大的优点,目前已逐步应用在各种不同的模式生物当中。
The field of DNA editing and medical genetics is changing much faster than we think. AI and CRISPR technology have been making revolutionary changes to the field of medicine. Artificial Intelligence is being applied in identification of harmful genes and treatment of disease. For the specific use cases and applications and numerous the importance of AI in healthcare, and its impact on the biotech industry could grow exponentially in the near future. Multiple new gene editing technologies in addition to Artificial Intelligence will cause major changes in healthcare.
The gene editing tool CRISPR, short for Clustered Regularly Interspaced Short Palindromic Repeats could help us to reprogram life. It gives scientists more power and precision than they ever had to alter human DNA. This new power includes the possibility of making people smarter. Even before CRISPR was used on human embryos, the technology was used to modify simple animals. There the goal was to demonstrate that the technology worked these experiments made us aware that with CRISPR, we could do a lot more than we previously thought we could. Scientists use CRISPR to change delete or add DNA to any organism from a human embryo to a pig to a wheat crop. CRISPR does this by subduing a specific part of the genome and then injecting a new piece of DNA into the genome instead.
So CRISPR is an acronym for basically a system that is from bacteria, that they use to kill and destroy the DNA of invading organisms, like a virus. But we can now use that system to cut and change our own genomes, it's basically a DNA cutting enzyme, that doesn't cut randomly. You can give it a barcode in the form of what's called the RNA molecule, that tells where that enzyme will cut in the genome. Let's say you have a terrible gene that's causing heart disease. We take this CRISPR system, we say here's where you need to go to cut, we can tell the enzyme to go and cut it put it into your cells. It'll go cut it and destroy that enzyme and delete it, and you can also use it to cut the genome and insert new pieces. So you can both subtract and add DNA at will now not just randomly. But what's important is you can tell it where to go and that's the big breakthrough.
Currently gene editing is already used in research fields such as human health, agriculture and environmental protection. However CRISPR as a tool for human genetic engineering is still in its early stage development. With the development of CRISPR as a tool for genetic engineering it is possible that more scientific advances are to come.
Let us consider the possible advantages and disadvantages of this technology. In case of diseases, CRISPR has a lot of potential advantages. CRISPR technology holds a lot of promises but we should be careful in applying it to humans animals and plants, as it may promote and accelerate some negative phenomena on the environment and on humans. Moreover many potential side effects have not been analyzed yet could it be conceivable that at one point in the future we could increase the average IQ of the population. According to UCLA neurobiologists the work in mice demonstrates the answer maybe yes.
Sometimes a person or animal is born with a mutation in their genome, these mutations can be small or large, and they can have many different effects, such mutations are often purposeless or random and they can have no effect on our intelligence. This shown by the fact that gene mutations that happened millions of years ago, are still present in the genes of living organisms on earth. Evolution has had plenty of time to correct them and eradicate them, but many of them are still there.
In fact many of the mutations that show up in human DNA are harmful, the apparently large genetic contribution has detrimental effects on everyday life. Ranging from a person being slightly more vulnerable to certain diseases to mental retardation to causing death immediately after birth. CRISPR technology in the future could enable efficient and affordable treatment of diseases such as diabetes, Alzheimer's, cystic fibrosis, muscular dystrophy or even rheumatoid arthritis.
We believe we understand how to slow aging, there are genes that predispose you to a long life. We could make offspring a family that would potentially live a lot longer, actually there are drugs that are in development to actually correct genetic diseases such as vision loss. What we're showing is in mice at least we can reverse the age of the retina, and restore the vision of old mice. So we'd reprogram the eye to be young again. So we now know that there's a set of genes called reprogramming factors also known as Yamanaka factors that are from named after this Japanese fellow, who won the Nobel prize in 2012. These factors are used all over the world even to reprogram skin cells other cells to be what we call pluripotent stem cells. These are cells that can be used to make new organs or new blood cells. But what people hadn't tried until recently was can you do this in a living animal, or are you just going to mess it u. And what we found out is that if you do it the wrong way you mess up the animal and it'll die. But what we've shown for the first time in this paper is you can do it in a safe way, and not only that reverse the clock make the cells young and restore how they work, and get back vision.
CRISPR was originally designed as a technique for editing the DNA in living organisms but its uses and capabilities have expanded substantially it is now used wildly for biomedical research including research into human genetics. One of the main issues concerning technologies such as CRISPR-cas9 is accuracy and safety. As mistakes can have significant and dangerous consequences when it comes to an individual's genome. However CRISPR technology has a lot of potential benefits. It is not a completely new idea and it can help treat diseases and genetic anomalies and many scientists have made potential progress that CRISPR cache 9 may be safer than viral therapies.
Many people have expressed concerns about crest by technologies because they think it is incredibly controversial. There are questions of ethics and fairness as it could probably only be available to the wealthy, to create designer babies with increased levels of intelligence. Intelligence is too complex to engineer, however many researchers think that intelligence is influenced by genes and environment. Genes affect the developing baby's brain and environmental factors influence how the brain is used, thus it is possible that genetically engineered babies could be smarter as a result of the increased amount of oxygen to the developing brain, thanks to gene editing. Research experiments already exist that creates smart mouse babies. Question is whether it is going to be possible to accomplish the same with human beings.
And in the mice, to restore the vision we have this three gene combination of these Yamanaka reprogramming genes. We put them into the eye and then we turn them on with a drug called doxycycline is the same drug we can feed to the mice turns on the reprogramming genes for a few weeks, restores their vision back to a young mouse, and then we just take away the doxycycline and antibiotic, and the mice have their vision back. That's the future, that you'll get a delivery of this virus, you'll take the antibiotic for a few weeks be fully rejuvenated, and the doctor says come back in a couple of decades we'll fix you again. I'll give you some antibiotics in a couple of decades but then it gets really weird if you have if you engineer your children to have this system, and you have people engineered to be able to be reversed in their age. Or let's say they have an accident, and their optic nerve gets damaged or they lose their hearing, give them a dose of an IV of antibiotics, and they become just like an embryo, they can rejuvenate, they can regrow their optic nerve, regrow their spine fixed back like new.
It may be possible that in the future, our genealogical records might be included in computer databases, and future computer programs could use it. The advancements in Artificial Intelligence and CRISPR technology can make it possible to one day, create a new breed of human machine hybrids, however the question concerning the safety of such technique in relation to humans is ongoing. We do not fully understand all the mechanisms related to the editing of the human genome. Additionally the long-term and short-term effects of the gene editing interventions in humans are still unclear.
CRISPR has given the scientific community a great leap. The prospect of improving our understanding of the genome will likely stimulate advances in both Artificial Intelligence and predictive medicine. The possibility of altering the sequences of genes and correcting the mistakes that were previously irreversible, opens many new possibilities for research. Nevertheless for now genetic editing technology is still incapable of making the hundreds of changes presumably necessary to make a super intelligent human, but the corresponding ethical issues deserve serious attention before these capabilities become a reality.
This work is licensed under a Attribution 4.0 International license.
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text:
A Cross of Iron
Also Discovered on Today's Run
Ok runners and readers, this might not seem like a running topic, and it isn't. But I heard it spoken today during a run on Audible, and found it to be so incredible that I had to post it. If you have any concern about where this world is headed, I promise you this quote from a US president will awaken you...
"Every gun that is made, every warship launched, every rocket fired signifies, in the final sense, a theft from those who hunger and are not fed, those who are cold and are not clothed.
This world in arms is not spending money alone. It is spending the sweat of its laborers, the genius of its scientists, the hopes of its children. The cost of one modern heavy bomber is this: a modern brick school in more than 30 cities. It is two electric power plants, each serving a town of 60,000 population. It is two fine, fully equipped hospitals. It is some fifty miles of concrete pavement. We pay for a single fighter plane with a half million bushels of wheat. We pay for a single destroyer with new homes that could have housed more than 8,000 people.
This is, I repeat, the best way of life to be found on the road the world has been taking. This is not a way of life at all, in any true sense. Under the cloud of threatening war, it is humanity hanging from a cross of iron."
Dwight D. Eisenhower (1953)
Supreme Commander of the Allied Expeditionary Forces - WWII
at August 16, 2019 No comments:
Somewhere Out on the Pacific Crest Trail
San Jacinto (left), San Gorgonio (right)
Nearly five hours into my run and approaching 9'000 feet at Onyx Peak outside of Big Bear Lake, I'm feeling the effects of altitude; dry mouth, light headed, energy levels fading. I stumble after tripping over an invisible rock, but keep running and hiking, trying to move forward and a little higher.
At this moment it's just me, the road beneath me and the piercing sun over my head.
I notice a shadow out of the corner of my eye. It's the shape of a hawk, but it isn't moving. I move closer, then look up. Above me was the silhouette of a large bird of prey, with an illuminated plume of feathers at the wing tips and tail. It appeared motionless as it floated in the sky, waiting. But for what?
I fumbled for my phone. But it was too late.
"The hawk symbolizes the ability to use intuition and higher vision in order to complete tasks or make important decisions. Animal guides can deliver important messages to us from beyond, and hawks definitely serve as animals that can heighten our spiritual awareness and help us along our paths." Power of Positivity
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The bright equation That makes you quake iterates Through eternity.
Seduce, nurture, scold, The battle of the sexes Won't be won this way.
Why study color In the lab? It is only Light made manifest.
Not to kill, rather Honor the small mammal's beauty As bodhissattva.


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