text:
Tennessee nurse wrote herself more than 100 prescriptions for 11,000 pills
Tennessee nurse prescribed herself 11,000 pills
Author: Brett Kelman, Nashville Tennessean
Authorities have broken up a prescription drug "diversion" scheme operating out of Nashville that sold nearly $60 million in secondhand pills to pharmacies nationwide, pawning them off as new medicines fresh from the manufacturers.
Getty Images / iStockphoto
A Nashville nurse had her medical license suspended after using a doctor's prescription pad to write herself 104 prescriptions for more than 110,000 pills of powerful opioids and muscle relaxers, according to newly released documents from the Tennessee Board of Nursing.
Patricia Tillis, a former nurse at the Hughston Orthopedic Clinic at TriStar Centennial, did not dispute the allegations and stipulated to them as fact in board documents. The documents say she wrote herself prescriptions for 8,764 pills of hydrocodone and 2,880 pills of Soma, a muscle relaxer, over a three year period.
Both drugs are known to be highly addictive and ripe for abuse, especially if mixed, and can be resold to addicts on the black market.
More: The opioid crisis hits home. Mine.
More: Number of new heroin users drops dramatically, but meth, marijuana use up, survey says
More: Dying daughter left without pain medication as mom took the meds for herself, police say
Tillis wrote the prescriptions using blank, pre-signed prescriptions slips that were intended for patient medicine refills, the board documents state. The prescriptions began in 2014 and continued until they were discovered in October 2017, at which point Tillis was fired from the clinic.
As a result of the fraudulent prescriptions, Tillis' nursing license was suspended in late August, according to board documents. Tillis can potentially regain her license if she enrolls in and completes the Tennessee Professional Assistance Program, or TnPap, which is designed to rehabilitate medical professionals who suffer from addiction.
Tillis had worked for the The Highston Clinic, previously known as Premier Orthopedics, since 2002. Clinic officials did not immediately respond to a request for comment.
Tillis' attorney Robert Kraemer said that the case was a "he said, she said" matter in which Tillis was told by a doctor she worked with that it was OK to use the pre-signed prescription pads. The doctor later "changed his story" when questioned by the health department.
Tillis used the medication to treat long-term pain from a prior surgery and did not believe had done anything wrong, but "didn't have the money to fight this," said Kraemer.
Tillis' suspension was revealed through a monthly announcement by the Tennessee Department of Health, which maintains public records on licenses for doctors, nurses, chiropractors, massage therapists and other health care professionals throughout the state. More than 100 disciplinary actions were included in the latest monthly report.
Follow Brett Kelman on Twitter at @brettkelman.


Valve cover breather for Dauntless 225 V6 Has 1" OD on bottom and either 5/8" or 1" on the top port. Tight fitting 5/8" to 1"rubber adapter included will not be seen when 1" hose from air cleaner is installed over it or you can adapt the air cleaner to 5/8" if you like. Valve cover grommet is also listed separately #1364117.


text:
Home/News/Movies/The Official Avengers: Endgame Trailer 3 Has Arrived
The Official Avengers: Endgame Trailer 3 Has Arrived
Vansh MehraApril 2, 2019
So far we've only seen 2 trailers, but Marvel has given us the official Avengers: Endgame Trailer 3, and it literally is the best of all! It has got everything you really wished for. Marvel is giving us exactly what we wanted, and without any further ado, let's just get right into it. Here's the third, and possibly final trailer of Avengers: Endgame:
It starts with Bruce Banner delivering his first ever dialogue in the entire marketing campaign of the film. We see all the snap surviving Avengers planning to take the fight to Thanos. This falls directly in line with the leaked description of a scene where Nebula and Rocket figure out Thanos' location, and everyone agrees to go and take him on. But this trailer reveals so much.
We see Tony returning back to Earth, and he reunites with Pepper. This confirms that Pepper will not be the one rescuing Tony and the Rescue armor will come in a bit later in the film. Tony actually makes it home on his own, without any external help. Moreover, we get to see the first live action look at the new Iron Man Mark LXXXV Armor. But the best part about the trailer is Cap and Tony working on the same page.
What's funny is that the money shot of this trailer actually comes in between and not the end! We see a few of the heroes take the fight to Thanos as they are sitting in the Benatar. War Machine's new suit is fully shown in the trailer, and it is different from the one we've seen in the Big Game Spot. Captain Marvel also has her new suit on.
The big reveal comes when Thanos arrives. Right before his arrival we see everyone a bit tensed. Considering all the Debris around the location of the battle, it does seem that the fight is taking place on Earth, at the Avengers facility. The trailer ends with the final shot of the Big 3, Captain America, Iron Man and Thor approaching Thanos.
This trailer obviously did a lot of misleading. As there was a lot of footage edited back and forth from different parts of the film. The trailer obviously comes as a courtesy of the tickets going on sale. Avengers: Endgame is going to make some major records with that as well.
Directed by Joe & Anthony Russo, Avengers: Endgame will open on April 26, and it'll presumably star Robert Downey Jr., Chris Hemsworth, Mark Ruffalo, Chris Evans, Scarlett Johansson, Benedict Cumberbatch, Jeremy Renner Don Cheadle, Tom Holland, Chadwick Boseman, Paul Bettany, Tom Hiddleston, Idris Elba, Danai Gurira, Peter Dinklage, Benedict Wong, Elizabeth Olsen, Anthony Mackie, Sebastian Stan, Gwyneth Paltrow, Benicio del Toro, Josh Brolin, Pom Klementieff, Karen Gillan, Dave Bautista, Zoe Saldana, Vin Diesel, Bradley Cooper, Chris Pratt, Paul Rudd, Samuel L. Jackson, Cobie Smulders, Tessa Thompson, Evangeline Lilly, Aaron Taylor Johnson, Cate Blanchett, Michelle Pfeiffer, Michael Douglas, Tilda Swinton, Jeff Goldblum, Katherine Langford, Stellan Skarsgard, Ava Russo and Brie Larson.
Here's the new synopsis of Avengers: Endgame:
"Thanos snapped his fingers in Avengers: Infinity War, and half the life in the universe instantly dissolved. Now a ragged group of surviving warriors, including Captain America, Black Widow, Iron Man, Thor, and the Hulk works to counteract the Mad Titan's genocidal action.
Since our heroes couldn't stop Thanos the first time, what makes them think they can win in a rematch? The answer may be in overwhelming power, thanks to Captain Marvel, or in the tiniest spaces between atoms accessible to Ant-Man. Avengers: Endgame will rewrite the Marvel Cinematic Universe as we know it. When it's all over, nothing will be the same."
Avengers: Endgame Avengers: Endgame Trailer 3 Marvel mcu
Vansh Mehra
Content creator. Just wanna share my passion for cinema with everyone.
10 Marvel Actors Who Had Auditioned For Other MCU Roles
20 Instagram Images of Chris Hemsworth That Will Prove How Crazy He Is IRL
20 Out of The Box Marvel Memes To Enjoy
20 Matt Murdock is a Really Good Lawyer Memes
Why No Way Home Prevented The Death Of Spider-Man (Both Maguire & Garfield)
6 Villains From Iron Man Comics We Want To See Next In Armor Wars
The Suicide Squad – Here's the First Look at the Characters of John Cena & Idris Elba
How Jake Gyllenhaal Helped Marvel in Creating Captain America
MCU's Illuminati Team Should Include a Member of The Eternals
5 Must Watch Bollywood Films

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Characterisation of faithful simple modules of primitive ring I am trying to prove the following:

$M$ is a simple $R$-module iff $M\cong R/\mathfrak{m}$ for some maximal ideal $\mathfrak{m}$ -- does that help?
Am I up to finding an explicit isomorphism?
Any help would be appreciated. Thank you.

redpajama_set_name: RedPajamaStackExchange


text:
Михаил Юрьевич Шишин (род. 16 марта 1956 года, Рубцовск, Алтайский край, РСФСР, СССР) — российский , академик Российской академии художеств (2017).

Биография
Родился 16 марта 1956 года в г. Рубцовске Алтайского края, живёт и работает в Барнауле.

В 1987 году — окончил Уральский государственный университет имени А. М. Горького.

В 1997 году — защитил кандидатскую диссертацию, тема: «Онтологические и методологические основания концепции ноосферогенеза».

В 2003 году — защитил докторскую диссертацию, тема: «Ноосферная концепция культуры».

В 2004 году — присвоено учёное звание профессора.

В 2017 году — избран академиком Российской академии художеств от Отделения Урал, Сибирь, Дальний Восток, член Президиума РАХ.

Заместитель председателя по научно-творческой работе Регионального отделения Урала, Сибири и Дальнего Востока РАХ в г. Красноярске (…г.)

С 1990 года — член Союза художников СССР, России.

С 2021 года — член Китайско-российской академии изобразительного искусства.

Член Общественной палаты при Губернаторе Алтайского края, заведующий кафедрой ЮНЕСКО и профессор кафедры архитектуры и дизайна Алтайского государственного технического университета имени И. И. Ползунова, шлавный редактор электронного журнала «Искусство Евразия», член редакционных советов и редколлегий журналов: журнал института комплексных исследований Гималаев «КАЛП» университета г. Шимла (штат Химачал-Прадеш, Индия); «Исторические, философские, политические и юридические науки, культурология и искусствоведение. Вопросы теории и практики» (входит в перечень ВАК); «Культура в евразийском пространстве: традиции и новации»; «Культурное пространство Русского мира».

Научная деятельность
Основные научные труды
Статьи в SCOPUS и WoS:
 Traditional Mongolian doctrine arga bilig: its sense and application to culture studies (on the example of Western Mongolian epic) (статья), Journal of Eurasian Studies. 2013, № 6, pp. 82-87, соавтор — Belokurova S.M.;
 The ethno-cultural concept of classical eurasianism (статья), International Journal of Environmental and Science Education. 2016, Vol. 11, № 12, pp. 5155-5163, соавторы — Ivanov A.V., Fotieva I.V., Belokurova S.M.
Монографии и альбомы по философии и искусству
 Евразийский мир: ценности, константы, самоорганизация (Коллективная монография), Новосибирск: Сибирское научное издательство, 2010. — 449 с., соавторы: Попков Ю. В., Иванов А. В., Тюгашев Е. В.;
 Учение арга билиг как ось монгольской культуры. (Монография), Барнаул: Изд-во АлтГТУ, 2013, соавторы: Белокурова С. М., Н. Цэдэв;
 Искусство Сибири и Монголии ХХ — начала ХХI в.: очерки истории и теории, Барнаул: Изд-во Алтгту, 2018, Уранчимэг Д.,Белокурова С. М., Умербек Б. и др.;
 Зов Афона: монахи и паломники В. Г. Калинина. (Альбом), Москва: Российская академия художеств, 2016;
 Палитра, опаленная войной. (Научная монография. Вступительная статья, редактирование, составление), Барнаул: Российская академия художеств, 2020;
 Наша общая победа. (Российско-монгольский альбом, посвященный 75-леттю Победы в ВОВ), Барнаул: Изд-во АлтГТУ, 2020, соавтор: Белокурова С. М.
Статьи в журналах перечня ВАК
 Основные черты стиля «метаисторический экспрессионизм» и его проявление в искусстве современных художников Сибири и Монголии (статья), Исторические, философские, политические и юридические науки, культурология и искусствоведение. Вопросы теории и практики. 2017. № 11 (85). С. 208—212.;
 Основные факторы в развитии искусства Монголии в XX—XXI веках (статья ВАК), Манускрипт. 2019. Т. 12. № 6. С. 207—211.

Награды
 Почётный работник высшего профессионального образования Российской Федерации (2011)
 Почетный гражданин Ховдского аймака, Монголия (2009)
 Почетный гражданин Баян-Ульгийского аймака, Монголия (2010)
 Лауреат международной премии за экологическую деятельность «Конде Наст Тревелл» (1997)
 Лауреат Всероссийской литературной премии «Белуха» имени Г. Д. Гребенщикова ВТОО «Союза писателей России» (2017)
 Почетный профессор Монгольского государственного университета культуры (2018)
 Почетный доктор Ховдского государственного университета (2019)
 Золотая медаль РАХ (2021)

Примечания

Ссылки

Выпускники Уральского государственного университета
Преподаватели Алтайского технического университета
Действительные члены РАХ
Члены Союза художников СССР
Члены Союза художников России
Почётные работники высшего профессионального образования Российской Федерации

redpajama_set_name: RedPajamaWikipedia


Drive to Baliguda after breakfast. Baliguda is in the district of Phulbani, through the beautiful countryside road full with small mountains of Sal forest, one of the entry point to the tribal highland of Orrisa. En-route visit weavers village at Itamati and some of the typical Orissan villages. Arrive at the hotel in the evening. Overnight at Baliguda.
Today after breakfast you will make a visit to the Barakhamba area to trekk to some of the remote villages of tatooed face desia kondh tribes. you can trekk short or long trek as you wish .Overnight at Baliguda.
After breakfast you will depart to Belghar area visit of a few Kuttiya Kondha Tribal Villages & Weekly Market at Kothagarh. Proceed to explore the villages of the primitive Kutia kondh Tribes, once famous for the human sacrifice. Living in the mountain / forest cores are friendly tribal community. Lunch on the way. Drive down to Rayaguda. Arrive in the evening.Overnight at Hotel.
Trekk to most primitive Dongria kondh villages in the Niyamgiri hills.You can also see and enjoy the Dongria kondhs men and women comming down from their mountains with different kinds of fruits and animals etc. to the weekly market. After visiting their villages , you can come down to see their interesting weekly tribal market where they mix with other community.The weekly market at Chatikona where Doms, Desias and Dongoriya Kondhas barter is an interesting event to watch. Later drive on to Jeypore. Enroute Kani tribal village.Overnight in Jeypore.
Morning the area we visit is the home of the approximately 6000 members of the fierce Bondas (naked people). They live in the remote hills and keep themselves isolated. They grow rice by shifting cultivation and keep domesticated cows and goats. They can only be seen when they come to trade at the local market, and we must time our visit to coincide with the weekly market day on Thursday.
The Bonda women are noticeable by their bead necklaces, striking brass and silver necklets and their shaved heads decorated with plaits of Palmyra leaves. You will also see the colourful Godabas,parajas and mali tribes. Afternoon drive back to Jeypore enroute visiting the pottery village Bapaniguda,Siriguda and Paraja tribal village at Lamptaput. Overnight at Hotel at Jeypore.
Breakfast. Morning proceed to witness the biggest tribal weekly market of Sanaparoja & Mali tribes in Kunduli 65 km away via Sunabeda. It is a very colorful market. Later drive down to Nandapur to visit village of Sanaparoja tribes. Visit village khilua. Saana Padar, Bada Padar with small trekking and later drive down to Jeypore.
Drive to Machkund, soft trek to primitive Boro gadaba villages. Watch the traditional dance called dhemsa. Back to Jeypore enroute Lamtaput market .Overnight in Jeypore.
Breakfast. Drive to Rayagada enroute visiting some Desia kondh/paraja villages and also the Jagannath Temple & Tribal Museum at Koraput (The Jagannath Temple is a new temple built in 1972. Here Non Hindus are allowed inside the Temples and all activities are similar to Jagnnath Temple of Puri). Lunch on the way. Overnight at Rayagada.
Breakfast. Proceed to Chilka enroute visiting the soura tribal villages/market. also visit Taptapani on your way.if anywhere nature reveals its enigmatic charisma, it is here in Taptapani, an exotic world of wonder. Enjoy the nature close to your heart and carry the memory years to come. A hot spring which till dates the local habitat use on a mark of Blessing.Overnight at Chilka.
Morning boat drive into chilka lake , the largest brackish Water Lake in Asia. In winter Chilika aflutter with thousands of migratory birds as far as from Siberia. Visit nalabana bird sanctuary, honeymoon island , Later also visit a few fishing village at Chilka -Lake, so that you are able to see the fishermen at work, who came here in search of prawns, mackerel, and crabs. Reach Puri via Birnasingpur, Tenta. Walk to a typical orissan village and savour their hospitality. Evening relaxe on the beach Overnight in Puri.
Morning after breakfast visit of Lord jagannath temple, Sankaracharya's Maths located on the downtown area of Puri & later drive to Konark (about 35kms) to visit the temple Chariot of the Sun God, built by King Langula Narasimha Deva in the 13th century AD in the golden era of Orissa art. Late afternoon visit Ragurajpur artisan villages & also some other villages with houses, decorated with Chita's for Goddess Lakshmi.Overnight at Puri.
Proceed to bhubanswar enroute visiting the colourful applique village of pipili where you can see the colouful orissan handicrafts and dhauli peace pagoda famous for the Ashokan rock edicts dating back to 2nd century B:C .afternoon visit of some of the ancient temples of bhubanswar belonging to (7th—11th) century A:D like Lingaraja temple, Parasurameswara temple, Mukteswara temple, Bramheswara temple, Raja-Rani temple etc. Overnight in Bhubaneshwar.
After breakfast Transfer to Bhubaneshwar Airport to board flight to Delhi or onward Destination.
To get this Orissa Tribal Tour customized to your requirements, please contact us. While filling the Contact Form, please specify the tour you like, travel dates, number of people traveling and the accommodation type / budget for your tour. Also, let us know what all changes you would like us to make and if you have any other requirements especially for families traveling with kids or elderly. You can ask us to add a night here and there, change the type of accommodations, meal plans, mode of transportation or even combine 2 or more itineraries to create a extended holiday tour of India for you. We will be happy to create a custom plan matching all your requirements. Our experts will be glad to help if you have any queries.


In this blithe tale, a French princess arrives incognito in colonial New Orleans and falls into the manly arms of a captain with a terrific baritone. This 1935 Best Picture Academy Award nominee and Oscar winner for Best Sound Recording remains a Hollywood milestone--and a total delight. From Warner Archive.


text:
Marching in the Heart of Texas
Known for cowboys, cattle, oil, The Alamo, football and marching bands, the Lone Star State sets a great example for music education.
Photo by Ryan Cain/Marching.com
Texas high schools are well-known around the country for their passionate football programs. The sport has brought together communities in tight-knit towns in the Lone Star State and reveals a sense of pride as residents pack their local high school stadiums. Under those Friday night lights is another institution—the marching band—that comes forth at halftime and is just as passionately followed as the football team.
Texas has some of the most competitive marching groups in the nation, and that has translated well in major national competitions such as Bands of America (BOA), with the most recent Texas national champion being L.D. Bell High School from Hurst, Texas, in 2007. Since 2000, the L.D. Bell Band has medaled at state and BOA events at least 27 times, and it has placed in the top five of every contest it has attended since 1998.
Like L.D. Bell, many of the Texas bands have a large number of members and have the same support from the community as for their football teams. What makes these bands so successful in recruiting people and sustaining thriving programs? There are quite a few factors, ranging from the culture of the state to the organizational structure of the marching bands themselves.
The Football Factor
Football will always be part of the discussion when it comes to marching band in Texas. The band is able to feed off the passion of football, says Van Mathews, director of bands at L.D. Bell. "In Texas, marching band is just as beloved as high school football in many communities," Mathews says. "There is pride in the schools in a community like Hurst, and band is a recipient of that support that happens every Friday night. The marching band is perhaps the most visible musical ensemble in the high school. I know people in the community who come out to the football games just to watch the marching band."
At Allen (Texas) High School, Anthony Gibson presides over one of the world's largest high school marching bands with more than 850 members, and he believes there is a symbiotic relationship between football and band. "I think that we are constantly trying to find a balance between the artistic approach to marching band and a sheer fact that we are there as part of the halftime for a premier sporting event that happens every Friday night," says Gibson, director of bands and performing arts for the Allen Independent School District. "So if you embrace the fact that you are part of the big picture, it becomes a successful relationship. I have always had very large bands and a lot of participation because of that partnership, and it lets the kids be involved within that community."
The organizational structure of marching bands in Texas also makes the groups stand out from much of the country. The University Interscholastic League (UIL) administers and creates rules and regulations for almost all athletic, musical and academic contests—ranging from football to debate club—for public schools statewide. One rule in Texas is the eighthour rule in which marching bands are only allowed to practice for up to eight hours cumulatively for every school week.
At The Woodlands (Texas) High School, the time crunch forces the band to become more efficient at practice. "The rule forces a band like us to see what we can do during that time and figure out how to manage that limited time," says Joni Perez, head band director. "A lot of the bands in our area have become more efficient with their practices, and it levels the playing field a bit as all bands have to adhere to that rule."
In addition, Texas high schools recognize the athleticism of marching band, typically offering students physical education (PE) credit in addition to fine arts credit for their participation.
"When we are doing our field shows, we are working just as hard and exerting just as much energy as the football team or other athletic activity," Perez says. "The school recognizes that, and the administration at schools like mine award PE credit. In turn, we are able to get even more students involved in band."
Another important aspect for Texas bands is a vertical chain of educators who work with students from elementary school through high school. Students start the process of music education at an early age, so when they join the marching band, they will already be musically adept. What is most important, though, is that the chain allows the marching bands to get students interested in the group early on.
"The instructors that work with the kids in elementary school will work with them in the middle schools," Mathews says. "By the time they reach high school, the same instructors will still be there with the marching band, and they can feel more comfortable about joining it. It creates a sort of family atmosphere within the group."
The same emphasis on consistency exists in the Allen Independent School District, and interest at an early age has helped the band there maintain its numbers. "We have had students who knew about the marching band early on from their instructors and knew that they wanted to do it," Gibson says. "It's wonderful to see them grow up within the music program in the district and become passionate about the band when they get here. You are able to be a part in their lives when they are still developing as people."
Community and Legislative Support
While many other states in the country are seeing cutbacks in music programs, Texas has become a case study in promoting music education.
"Texas is a little different than other places for a lot of reasons," says Vince Chiappone, a representative from national retail chain Music & Arts. "There's a culture here that has been created over time by parents, teachers and administrators who get the attention of state legislators to keep music in the schools. Many bands are well-funded through booster organizations by parents."
Passionate parental support has been key in expanding the financial resources of marching bands.
"The parents pay a school tax that they are happy to pay as they know it will be put to good use such as for a good music program," Chiappone says. "A lot of the parents that are involved in the band have been in the band themselves and help out with boosters or reaching out to legislators as a way of giving back and as a matter of pride with the school."
Despite of—or perhaps because of—the intense competitiveness of marching band in Texas, the lessons learned during band apply to all future walks of life. "We want our students to be successful when they move on in life," Gibson says. "Not all of them will go on and continue to do music professionally as some might go into doing baseball or doing science. What they will have had is . . . an atmosphere of a supportive group during what can be an angsty time in life and that what they did in marching band can apply to their current occupation."
Jeremy Chen is a senior majoring in broadcast journalism at the University of Southern California (USC). He marched cymbals for two years at Rancho Cucamonga High School before playing bass drum and snare at Upland High School. He is currently a snare drummer and office staff member for the USC Trojan Marching Band. He aspires to one day become a correspondent for the BBC.
Tags: marching bandHalftime Magazinemarching artsUILUniversity Interscholastic Leaguetexas music educationtexas musictexas uilld bellthe woodlandsallen independent school district
Hear Ye! Hear Ye!
Drum Corps 9-1-1
Yoga and Sound
In the last number of years, I went from having nearly constant major back issues, where it was difficult to be on tour and walk ...


text:
Scientists create a genetic 'pen' that corrects common heart conditions | Science and Technology
Gene enhancing applied sciences which have revolutionized drugs since 2016 will also be used to deal with frequent coronary heart ailments, the primary reason behind demise in people, in line with a research just lately printed by one of many world's main scientists, Eric Olson, Ph.D. , from the US. His crew was in a position to modify two letters – or bases – of the roughly 3,000 million that make up a mouse's DNA. This modification was sufficient to silence a protein related to a number of cardiovascular issues. Olson is cautious, however highlights the potential benefits of this new technique: As a result of coronary heart cells final a lifetime, it is solely a matter of creating the change as soon as.
DNA is sort of a recipe guide for making proteins, little machines that care for the principle duties in an organism: carrying oxygen via the blood, combating viruses, and digesting meals. This clue is written in 4 letters, repeated thousands and thousands of instances: ATGGCGAGTTGC … Every of those letters is the primary of a chemical compound with totally different quantities of carbon, hydrogen, nitrogen and oxygen: adenine (C₅H₅N₅), cytosine (C₄H₅N₃O), guanine (C₅H₅N₅O) and thymine (C₅H₆N₂O₂) . Olson's group used an "correct stylus" to vary the A to G a number of instances; Now the recipe is not the identical.
This pin-sharp pen dates again to 2003, when Spanish scientist Francis Mujica serendipitously found that some microbes from the Santa Pola salt flats in Alicante, Spain, used molecular scissors to determine invading viruses and minimize their genetic materials. Mojica, from the College of Alicante, known as this mechanism CRISPR. Then, in 2012, French biochemist Emmanuel Charpentier and American chemist Jennifer Doudna noticed that these microbial scissors might be used to change the DNA of any organism, a discovery that earned them the Nobel Prize in Chemistry. Now, Eric Olson's crew has used one of the crucial refined variations of those CRISPR instruments: the so-called base editors, invented in 2016 by American David Liu, a Harvard chemist thought-about one of many geniuses of contemporary science.
Liu himself praises the brand new trial, saying it is a intelligent use of core editors that raises the potential for not solely treating sure forms of coronary heart illness, but in addition stopping their growth, both spontaneously or after harm. Till now, primitive CRISPR applied sciences have targeted on attempting to appropriate particular mutations that trigger uncommon ailments. The brand new research helps increase the therapeutic functions of important editors past merely treating a single gene mutation. Particulars of the experiment have been printed within the journal Science.
Eric Olson, of the College of Texas Southwestern Medical Heart, spoke about his analysis to EL PAÍS by way of video convention from Dallas, Texas, accompanied by a Spanish colleague from his lab, biologist Xurde Menéndez Caravia, co-author of the brand new research, who defined that the outcomes of the primary proof-of-concept are promising. very. This system seems to be protected in mice; Now, what comes subsequent is an exploration of potential long-term results.
The researchers modified the recipe for a protein known as CaMKII delta, overactivation of which causes a number of cardiovascular issues akin to arrhythmias, coronary heart failure, or harm to the guts muscle after myocardial infarction. By altering two letters within the recipe, the ensuing protein just isn't hyperactive. Olson's crew used this system in mice with broken hearts after a coronary heart assault, a phenomenon generally known as ischemic reperfusion harm. Rodents' organs have regained perform after genetically modifying their cells. As a therapy concentrating on giant populations, it might be revolutionary. We're speaking about myocardial infarction: doubtlessly thousands and thousands of individuals will be handled with this system, "says Menendez-Caravia.
Spanish biologist Xurde Menéndez Caravia, in his laboratory, in Dallas (USA).UTSW
The US firm Verve Therapeutics is already utilizing an analogous technique to disable a gene linked to excessive ranges of dangerous ldl cholesterol. After getting promising ends in monkeys, the corporate began a scientific trial with folks in July. The distinction, Olson explains, is that Verve Therapeutics makes use of core editors to show off a gene fully, whereas his crew makes use of them to subtly appropriate its perform. David Liu himself based an organization, Beam Therapeutics, which, with major editors, started a trial in November in sufferers with sickle cell anemia, a genetic dysfunction of pink blood cells.
Olson is conscious of the restrictions of his research. "Does it work in animals moreover a mouse? We've not examined it, after all, in primates, or definitely not in a human. So we'd like to verify it is efficient and protected. Additionally, I feel the long-term results of this therapy have to be investigated, as a result of as soon as it is corrected, it is Perpetually," the scientist admits.
For geneticist Lluís Montoliu, of Spain's Nationwide Heart for Biotechnology, database editors are a tremendous achievement. "It was an ideal concept that David Liu had in 2016, and in simply six years, we're already speaking about functions in animals and even in people," he celebrates. Montolio factors out that the Grammar Editors just lately saved the lifetime of Alyssa, a British woman who had a really aggressive leukemia and was handled with donor white blood cells that had been modified with the revolutionary micro-tipped pen.
David Liu's lab is consistently enhancing its core editors and usually comes out with new, extra refined variations, Montolio says, a lot in order that geneticists all over the world can hardly sustain. Nevertheless, the Spanish scholar maintains that the approach remains to be not excellent and might produce some undesirable adjustments within the letters; This occurred in Erik Olson rats, though there seemed to be no adversarial results.
Heart specialist Javier Lemeres can be very cautious. At his hospital, Val d'Ebron in Barcelona, Spain, they studied molecules that have been in a position to cut back coronary heart harm from ischemia and reperfusion in mice and even in pigs. "There was very optimistic information, however when these molecules have been examined in people, the outcomes weren't the identical," explains Limeris, MD, chair of the Division of Household Cardiology and Cardiac Genetics on the Spanish Society of Cardiology. Nevertheless, the physician additionally admits his enthusiasm: "Gene enhancing opens up a really big selection of potentialities. I feel it's the third revolution in drugs, after surgical procedure and medicines."
Categories Genetics
Wetland forests with unique flora and wildlife are now protected
Inside breakthrough nuclear fusion may be a step into unlimited clean energy in the distant future


text:
Trileriai ir suspenso literatū...
Meet John MiltonHe considers himself an artisan. A craftsman. His trade is murder.Milton is the man the government sends after you when everything else has failed. Ruthless. Brilliant. Anonymous. Lethal. You wouldn't pick him out of a crowd but you wouldn't want to be on his list. But now, after ten years, he's had enough - there's blood on his hands and he wants out. Trouble is, this job is not one you can just walk away from. He goes on the run, seeking atonement for his sins by helping the p…
Autorius: Mark Dawson
Leidėjas: Welbeck Publishing Group
Puslapiai: 320
Formatas: 15.8 x 24.1 x 3.8 cm, kieti viršeliai
The Cleaner | Mark Dawson | knygos.lt
(3.70 Goodreads įvertinimas)
kieti viršeliai
Meet John Milton
He considers himself an artisan. A craftsman. His trade is murder.
Milton is the man the government sends after you when everything else has failed. Ruthless. Brilliant. Anonymous. Lethal. You wouldn't pick him out of a crowd but you wouldn't want to be on his list. But now, after ten years, he's had enough - there's blood on his hands and he wants out. Trouble is, this job is not one you can just walk away from.
He goes on the run, seeking atonement for his sins by helping the people he meets along the way. But his past cannot be easily forgotten and before long it is Milton who is hunted, and not the hunter.
A career of state-sanctioned murder has taken its toll. Milton is troubled by nightmares, a long line of ghosts who torment his dreams. He resolves to make his next job his last and, then, perhaps, he can start to make amends for everything that he has done.
Sharon Warriner is a single mother in the East End of London, suicidal with fear that she's lost her young son to a life in the gangs. After Milton saves her life, he promises to help. But the gang, and the charismatic rapper who leads it, is not about to cooperate with him.
As London burns through summer riots, Milton finds himself in unfamiliar territory, dealing with an unfamiliar foe. And when his employer sends another agent after him, the odds against him are stacked even higher.


You are downloading the BookofFate XAP file v1.0.0.0 for Windows Phone. BookofFate is a free and useful Kids & Family app: This application provides answer to questions of life which otherwise are difficult to solve and is based on a book formerly in possession of ... You can now download the offline XAP file to install & try it.
Note: To install it manually from an SD card, you should choose one of the server location above to get the offline BookofFate XAP file, move the file to your phone's SD card and then tap 'Install local apps' in the phone's App list.
Appx4Fun.com only share the original XAP installer for BookofFate v1.0.0.0.
All the Windows Phone apps & games here are free for home or personal use ONLY. BookofFate is the property and trademark from the developer Sameer, all rights reserved.


text:
Link Between Synaptic Activity, Aβ Processing Revealed
The connection between synaptic activity and Aβ production in vivo runs through the endocytic pathway, according to a new study from John Cirrito, Steven Mennerick, David Holtzman, and colleagues at Washington University in St. Louis. In the April 10 issue of Neuron, they present evidence that 70 percent of Aβ production in the brain requires endocytosis, and a large fraction of that depends on synaptic activity. By linking synaptic activity to Aβ production through the elevation of endocytosis, the work places Aβ production in the context of the physiological activity of neurons.
The paper follows on Cirrito and colleagues' earlier work showing that synaptic activity regulates Aβ levels in interstitial fluid (ISF) surrounding cells in the brain (see ARF related news story). Since amyloid precursor protein (APP) is processed in endosomal vesicles after uptake from the cell surface, the authors hypothesized that endocytosis induced by synaptic activity might serve to deliver more APP into the processing pathway, and that that might account for the increased Aβ production as a result of synaptic activity.
To test this idea, Cirrito used in-vivo microdialysis to measure Aβ over time in the ISF of the hippocampus in living, moving three-month-old Tg2576 APP transgenic mice. The implanted dialysis electrodes allowed the investigators to administer and measure the effects of pharmacological modulators of endocytosis and synaptic activity. For starters, inhibition of clathrin-mediated endocytosis with a dynamin dominant-negative peptide (dynamin-DN) inhibitor caused a 70 percent drop in Aβ within four hours. This is similar to what is seen in cell culture experiments when endocytosis is blocked. The effect on Aβ was not merely due to a depression of synaptic activity, since dynamin peptide itself did not affect synaptic transmission as measured by spontaneous or evoked electrical activity. Dynamin-DN did not alter Aβ clearance, the authors show, suggesting that the decrease resulted from lower production.
Next, the investigators asked whether elevation of Aβ production by synaptic activity required endocytosis. They found that stimulating synaptic transmission with either picrotoxin or a metabotropic glutamate receptor antagonist increased production of Aβ, and this was blocked by the dynamin-DN peptide. They found a similar role for endocytosis in the production of Aβ from endogenous APP in non-transgenic mice; this supported the idea that this phenomenon is part of a normal pathway for Aβ production, and not a consequence of the transgene, the authors write.
To determine the relative contribution of endocytosis and synaptic activity to Aβ production, the researchers measured Aβ levels after co-administering the neurotransmission blocker tetrodotoxin (TTX) and the dynamin-DN peptide. They found that when they gave the endocytosis inhibitor first, Aβ levels plummeted and they saw no further decrease upon adding TTX. However, when they administered TTX first, subsequent inhibition of endocytosis was able to decrease Aβ slightly more. These results suggest that of all the endocytosis-dependent Aβ production, most but not all occurs in response to synaptic activity.
"We estimate that the majority of ISF Aβ in vivo is generated through endocytosis of APP and that, in the brain, synaptic activity plays a primary role in that process," the authors conclude. The results are consistent with observations in people that Aβ accumulation is enhanced by seizure activity (Mackenzie and Miller, 1994; Gouras et al., 1997) and occurs most conspicuously in highly active regions of the brain (see ARF related news story). Further work will be required to understand the conformation of Aβ that is released via this pathway, its physiological role, and its relation to aging and AD.—Pat McCaffrey
Paper Alert: Synaptic Activity Increases Aβ Release 22 Dec 2005
Network News: Images of AD Brains Reveal Widespread Snafus 26 Sep 2005
Mackenzie IR, Miller LA. Senile plaques in temporal lobe epilepsy. Acta Neuropathol. 1994;87(5):504-10. PubMed.
Gouras GK, Relkin NR, Sweeney D, Munoz DG, Mackenzie IR, Gandy S. Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Ann Neurol. 1997 Mar;41(3):402-4. PubMed.
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 2008 Apr 10;58(1):42-51. PubMed.


Tabs entertains the notion that a psychedelic state is not a transient objective experience generated within the brain, but rather a fixed landscape that exists indefinitely and may be accessed by any number of portals - chemical, meditative, sexual, spiritual, or otherwise - and applies this same concept to the digital landscape, to which any internet enabled device may serve as an access point.
The paintings presented in Tabs borrow equally from traditional oil painting techniques and from the pervasive aesthetic tropes of web-user interface. Emma's process is much in the tradition of Plein Air painting, a 19th century French movement in landscape painting which required that the artist work from direct observation while immersed within the environment being examined. Coming from a background of classical figure painting, she is most interested in the way that the human form is represented in this digital environment, which, though owned by Man is operated by Machine and is still very much under construction. These essentially featureless protagonists and their non-body parts exist in a static state unless literally animated. Their characteristics may be manipulated with unlimited frequency and intensity while not subject to any known laws of physics, a condition mirrored only by the psychedelic state.
Named in homage to both a very popular psychedelic access point and for the organizational mechanism used when navigating a digital landscape, the paintings presented in Tabs are meant to serve as archival documentation of this space in its' infancy.


Campbell Wine Lined Valance 60"
Bring the simple beauty and charm of colonial style to your room when you cove your window in this Campbell Wine lined valance. This window treatment displays a deep burgundy and tan geometric design on a 100% jacquard woven fabric. You can easily create a full look when you pair this valance with our matching tier curtains. Find other curtain styles to bring grace and style in rooms throughout your home when you visit our complete Campbell Wine curtain line.


Kaleh joosh is a quick and simple vegetarian soup enriched with calcium and protein. It is originally from Yazd and Khorasan provinces of Iran, But it's known all around the country and in every region the recipe has slight changes.
The main ingredients for this soup are walnut and Kashk (whey), which is a thick whitish liquid similar to sour cream. It is available as a liquid or in a dried form, which needs to be soaked and softened before it can be used in cooking. Kashk is traditionally produced from the leftovers of cheese-making process (more specifically, the milk used to make it) and is a byproduct of curdled milk (buttermilk). It can be found in any Iranian or Middle Eastern grocery stores.
Heat oil in a pot over medium heat. Dice the onions and saute them until golden.
Mince the garlic cloves and add to the pot.
Add turmeric, salt and pepper and stir well.
Add the mint to the pot and stir.
Ground the walnuts, add to the pot and fry along.
Add Kashk to the pot and stir thoroughly until well mixed. You can add boiling water to the Kashk to soften, if needed.
Add a cup of water and allow it to simmer for 15 minutes over low heat.
Thanks for the recipe, I love this dish a lot. so damn tasty and healthy.
Specially now that i became vegetarian this dish definitely could be add to my menu.


Critics of liberal education seem obsessed with immediate practicality. Or at least the visibility of practicality.
For example, Gallup advises higher education institutions to "demonstrate their value to consumers by increasing their alignment with the workforce." The author also suggests that the field of liberal arts might attract more students after some "rebranding" to avoid the political connotations associated with the word "liberal." Such a name change, the logic goes, would allow the humanities to promote and emphasize their relevance to students of the 21st century. A post on Gallup's website responds to a poll in which many U.S. adults expressed concerns about the financial stability, value, and overall effectiveness of higher education.
Students in Geology 101 work on an in-class assignment. Problem-solving and critical thinking skills apply to all forms of intellectual development, from the humanities to the sciences.
Note the language used to describe the basic structure of the university: With students as consumers, colleges must compete for their business. In an earlier post, I discussed the problems that arise from conflating teaching with customer service. From that perspective, graduation seems less an accomplishment than a financial transaction, and the human element of learning becomes marginalized for the sake of careerism.
How can the humanities demonstrate their value—often intangible—to students? As Elizabeth H. Bradley explains in a recent Inside Higher Ed article, students who study the liberal arts have a strong capacity to "recognize the larger patterns of human behavior." While I agree with her observation, it's still difficult at first glance to say exactly how the study of literature, visual art, photography, film, and so on prepares students for the non-academic workforce. But that's what makes the humanities more vital than ever.
The idea here is that a central tenet of the humanities—concern for and exploration of the human condition—becomes lost when this particular field of study functions only as an instrument for financial or occupational satisfaction. The capitalist pursuit does a disservice to humanistic education, because it ignores the potential for literature and art to make an impact in the context of social justice, for example, or to raise awareness about historical and systemic inequalities. Outside the narrow perspective of the workforce, the humanities have tremendous value. Studying the humanities isn't practical or pragmatic in any materialist sense, and it shouldn't have to be.
But to return to an earlier question raised by the Gallup post: what is the workforce? Is this the same arena as the "real world" that is so often held up as an intimidating contrast to one's college years? If so, then the workforce offers a range of opportunities for which higher education institutions cannot completely account.
While universities can provide internships and training courses for specific occupations, the idea of a workforce is too nebulous for any cohesive design at alignment. Structural attempts to holistically align the university curriculum with the job market will change the university into a vocational school. If that happens, then students will not have access to courses—in the humanities, for example—that offer no practical advice or preparation for a particular job.
The good and the beautiful, sure, but also the bad and the ugly, to which many of us are also naturally drawn. Rather than present literature, art, and film as timeless texts that hold timeless truths, as Wilson does, it's important to communicate to students that one seeks out the humanities for problems, not for answers. For ways not to act, as well as for models of ethical and moral behavior.
Studying the humanities in a rigorous, committed manner helps students acquire skills that will benefit them as applicants and employees. As Gerald Greenberg explains in this Washington Post article, humanities students bring to the workplace valuable "problem-solving and critical thinking abilities." These skills are not specific to any particular job. Instead, they apply to a range of occupations. An education in the humanities might seem opaque to those who seek a one-to-one correlation between one's degree and one's career. However, with greater consideration of the actual tasks and exercises presented to students in humanities courses, it becomes more and more clear how well-equipped such students are for work both inside and outside the academy.
Of course, college is expensive, and many students likely believe that visual arts or creative writing courses offer nothing but a waste of time and money. It's beyond the means of this post to offer a solution for the rising costs of higher education, but I don't think that the answer for the humanities lies in emphasizing productivity and practicality. Instead, a liberal arts education should present itself in honest, direct terms: these classes are frustrating, challenging, and often overwhelming in their scope. And yet, while students won't necessarily be able to apply the content of such courses to their future occupations, they will be able to deal with the many frustrations, challenges, and overwhelming sensations that arise in any workplace environment. The humanities offer a distinct, unorthodox path to job preparation, one that finds comfort in the uncomfortable.
I understand and sympathize with their frustration, but I also want them to embrace that feeling, to work in a space of indeterminacy, and see what they can produce under those circumstances. My attempt is to discourage even more troubling questions that often arise in writing classes: "What do you want me to say?" or "If I say this will I get an A?" I refuse to treat my students like employees, to give them narrow confines of expression, to reduce all writing in the academic space to a letter grade.
Why? Because unlike Wilson, I do not believe that "critical thinking" encourages a "skeptical, suspicious view of the world." Instead, it's my opinion that critical thinking, which students must perform independently to achieve the higher-end goals of a particular assignment, allows for a more comprehensive and considerate view of the world.
The value of the humanities, then, lies in the processes of critical thinking, interpretation, discernment, and deliberation. It might not be possible to tell from a prospective employee's transcript that her Introduction to American Literature course required these forms of mental and emotional work, but it will certainly become clear over time that such skills often originate from the tasks one performs in humanities courses. These classes have long-term rather than short-term benefits, and without them (or without encouragement to enroll in them), any alignment for the workforce will have serious gaps in its foundation.


The hallmark of a twill weave is the diagonal lines that form as a contrasting weft crosses the warp. The classic example is good old denim jeans. In this "plaited twill", the diagonals are arranged in such a way as to produce a fascinating optical illusion - it looks like the two colors are braided together on a larger scale, on top of the interlacement that forms the cloth itself. It is great fun to weave as I watch the pattern emerge.
I decided to use this pattern for table linens (a set of placemats and maybe a runner or two, at the end of the warp) because it is interesting without being distracting. Red is a good color for kitchens and dining rooms, as it suggests the warmth of the hearth fire, and stimulates the appetite. It is appropriate for festive occasions, as well as every day meals. Besides, it is certainly a cheerful color to work with.


The European Union's (EU) upcoming General Data Protection Regulation (GDPR) comes into force on May 25, 2018, and will require U.S. businesses to protect EU citizens' personal data. Even if you don't think you're at risk, seemingly innocent data such as online addresses from EU users could expose you to severe fines.
Conduct a data audit across your entire organization. Determine what information is collected across all of your organization's departments and operations.
Determine how the data is processed, stored and retained. Identify which of the GDPR's six lawful bases your business uses to collect data, where data is stored, the record keeping process for data use and your business's policy on data retention.
Examine your vendors' and partners' data management practices. Make sure that business partners such as cloud service providers, payment processors and marketing firms are ready to comply with the GDPR. Even if your own data protection measures are in place, you can still be held partially liable for a vendor's failure to comply.
Create a plan that accounts for the GDPR's requirements on consent, data subjects' rights and breach notification. Meet with management, IT, legal teams and other stakeholders to create a GDPR compliance plan that's unique to your business. Keep in mind that your plan should address how your business will collect and record data users' consent to process information, comply with requests to delete or transfer data, and report data breaches to supervisory authorities.
What is Blockchain Technology and How Can it Improve Supply Chains?
Online technologies like smartphones, internet of things networks and cloud services have helped businesses examine their supply chains up close. However, a lack of transparency between vendors and the use of separate management systems often leads to confusion, delays and lost business.
U.S. businesses that don't comply with the EU's upcoming General Data Protection Regulation could face fines of up to €20 million or 4% of their global annual turnover.
To solve these problems, many businesses have turned to blockchain technology—a platform of encrypted, shared records that can be instantly accessed by all parties involved in a supply chain. Blockchain systems work by recording a separate record, or "block," every time a supply chain progresses. This record is then encrypted and used to verify all subsequent blocks, which prevents alterations to records. And, because blockchain systems can be viewed by all members of a supply chain, businesses can get an instant and reliable idea of a product or task's status.


text:
609-924-2613 office@princetonumc.org
Statement of Welcome
Photo Tour of Church
Our Stained Glass Windows
End Racism
Pastor's Weekly Update
PUMC 2020 Audit
This Week's Worship
Tuesday Prayer Service
Longest Night Service
Members of our Church participate in a number of organizations that reach out to our community, state, nation and to the needs of people throughout the world. Many of these are also supported financially by our church through the Outreach Budget. Here is a list of them:
Africa University — We support the work of Africa University through our Outreach budget.
Aids Resource Foundation for Children — We usually give to this organization through the Christmas Card Alternative. Formerly it was "St. Claire's Home for AIDS Babies"
Arm in Arm (formerly the crisis ministry of mercer county)– Works to prevent hunger and homelessness in the Princeton and Trenton area through many services including a food pantry, money for rent and help with utilities and medicines.
Church World Service (CROP Walk) — We help raise funds for use in fighting hunger around the world through the annual fall CROP walk.
CONTACT of Mercer County — A telephone ministry which provides free and compassionate listening, crisis intervention and safety services to the needy.
Habitat for Humanity, Burlington and Mercer County— Helps build new homes and renovate older ones in an effort to provide affordable housing.
Heifer International — The children of our Church School help raise funds to help families in the third world buy farm animals.
HiTops — A Princeton, NJ organization that promotes adolescent health and well-being through counseling, health education and a health clinic.
Homefront — Provides transitional housing, self-sufficiency training and counseling to families in the Trenton area who are moving from welfare or homelessness to affordable housing.
Housing Initiatives of Princeton — Helps families in the transition from homelessness to self-sufficiency by providing temporary housing and other assistance while they get back on their feet.
Isles — A community Development and environmental organization that fosters self-reliant families in healthy, sustainable communities.
Mercer Street Friends — Provides educational opportunities, job training, food, clothing, counseling and health services to the families of the Trenton area.
Not in Our Town — An interracial, interfaith social action group in Princeton committed to speak truth about 'everyday racism' and other forms of prejudice and discrimination. Composed of representatives from faith congregations, it supports and promotes social justice, economic justice, and educational equity for all. Its goal is for Princeton to become a town in which the ideals of friendship, community, and pride in diversity will prevail. Also visit the Not in Our Town blog for additional information.
Pastoral Care at Princeton Healthcare System — Provides counseling to hospital patients and their families as they cope with medical and other crisis issues. Navigate to the Religious Ministries page on this website.
Princeton Community Housing — Provides 463 units of affordable rental housing to families and individuals residing in the Princeton area.
Princeton Senior Resource Center — Provides programs and services that assist senior citizens, their families and their caregivers.
Princeton Young Achievers — An after-school program which provides homework support and individual tutoring and mentoring to children of low-income Princeton families.
The Wesley Foundation at Princeton University — A campus ministry of the United Methodist Church which serves students at Princeton University.
Trenton Area Soup Kitchen — Provides meals to the hungry, tutors adults and encourages self-sufficiency through a number of programs.
United Front Against Riverblindness — Works to eliminate Riverblindness in the Kasongo region and two other regions of the Democratic Republic of the Congo through the administration of Mectizan, a Merck medication. Dr. Daniel Shungu, a member of our church is the Executive Director.
United Methodist Communities — Provides quality housing and care services to senior citizens.
Womanspace — A residential emergency shelter program for battered women and their children. Also provides counseling, advocacy and legal assistance.
Princeton United Methodist Church | 7 Vandeventer Ave, Princeton NJ 08542 | Email: office@princetonumc.org | Telephone: 609-924-2613


The superpowers of the world are at war. Fears of an impending nuclear apocalypse are on everyone's lips. Critical shortages of gasoline, food and clean water have become an everyday occurrence, forcing once law abiding citizens to band together and take drastic action in order to stay alive. Sporting goods stores, now long out of business, have all been looted of their weapons. Some are used for personal protection. Most are used for personal acquisition. All pose a threat to those whom would keep the law.
The last standing Australian law enforcement organization, the Main Force Patrol, does what it can to keep order, but they now face an uphill struggle against the ever growing anarchist threat.


text:
Stocks A to Z / Stocks A
/ American Tower Corp. (AMT)
Author: jambo297
Number: of 244
Subject: Re: Amt
apeaceofmind,
Linked here's a comprehensive article on AMT. http://seekingalpha.com/article/1636192-american-tower-the-c...
It is a bullish case.
IMHO here's 3 reasons explaining what's happening to the current price...
1. AMT became an REIT this year or last year(?). Mr. Market is treating AMT as a typical REIT - subject to downturn when interest rates go up (which they are now), and general REIT's suffer. AMT is, however, not a typical REIT.
2. AMT is, however, taking on more debt and the market may be worried about this. AMT already has 8.8B in LTD. Cash flow is healthy and current ratio remains strong.
AMT management says the new debt's for growth via acquisition.. On Wednesday, American Tower (NYSE: AMT ) issued a press release saying it has "announced the pricing the of its registered public offering of senior unsecured notes due 2019 and 2024," in the amounts of $750 million and $500 million, and with interest rates of 3.4% and 5%, respectively.
Altogether, after deducting underwriting discounts and estimated offering expenses, this should net the company just under $1.24 billion.
Also according to the release, American Tower plans on using its new cash to "repay existing indebtedness incurred under the 2013 Credit Facility and/or other credit facilities, finance recently announced acquisitions and for general corporate purposes.
More in this article...http://www.fool.com/investing/general/2013/08/15/american-to...
3. and back in July AMT reported "revenue rose 15.9% to $808.8 million, versus an expected $814.7 million." Earnings were on target at 0.52/shr. But with a price in the $70's, a P/E ratio well over 30 and EV/S @ 10+, AMT is priced for big growth. So this small disappointment hurt big time.
Many of us think AMT is, long term, going to come through with the big growth, especially internationally, where cell techonology is the only way people will communicate. Mr. Market isn't as patient as we are.
Long AMT


text:
October 2, 2007: Hobby Games: The 100 Best
My copy of Hobby Games: The 100 Best arrived yesterday which automatically meant that last night was devoted to reading. If you're unfamiliar with the book, it's a recent release from Green Ronin Publishing, edited by James Lowder, in which 100 game designers talk about 100 different games.
Why do I have a copy, you ask? Besides the obvious answer - it's a book about games - there's also the simple reason that I contributed to the book (I wrote about Battletech). After reading some of the entries in the book, though, I feel like I completely snuck in when no one was looking. I mean, I'm in the same book as such well-known designers as Reiner Knizia, Richard Berg, Jeff Grubb, and even a couple of guys named Steve Jackson. I'm definitely not worthy.
I can honestly say that even if I hadn't been given the opportunity to add my own rambling insanity to the book I would have shelled out the $24.95 for a copy. After all, where else am I going to get the chance to hear what Mike Pondsmith has to say about Traveller? This is definitely my only chance to sit back and smile as Matt Forbeck tells me all about Space Hulk. And I would hate to ask Vegas what the odds are of me sitting down with Alan Moon and listening quietly as he discusses Descent.
If you're a fan of games, and I'm talking about everything from Acquire to D&D to Naval War* to Paranoia, you owe it to yourself to add the book to your reading list. It's enjoyable, informative, and one of the only books published this year that every gamer should own.
I'm holding out hope for a second volume.
* John Tynes' essay makes me want to track down a copy of this old game (it has now been a decade since I last played Naval War).


This entry was posted on Saturday, September 12th, 2009 at 8:21 pm	and is filed under Daily Happenings. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.


It's the 11th Anniversary of Bridging Two Worlds, the psychic event to benefit St. Jude Children's Hospital!
Visit with Susan Anderson to learn about your personal life, professional life, or spirits around you. Most guests will get a reading during the show! Tickets are only $25 per person with all tickets sales, benefiting St. Jude.


The months that followed were full of confusion, violent emotions and erratic sobbing episodes, if not from me, then from one of our four young children. After about a month, we saw the lives of family and friends go on, Jacob seemingly forgotten by all but us. I remained lost, allowing condemnation and grief to toss me around like those pale and brittle maple leaves that bounce on frozen ground, long after autumn has officially ended. Despite the love of constant friends, I felt I was in a place no one could understand. I felt alone.
It's an important book, one that I could not find, despite desperate efforts, when I searched high and low for comfort and answers over a decade ago.
Through The Eyes of A Lion is Levi Lusko's chronicle of his 5 year old daughter's death from asthma, and the wake that her traumatic early passing left behind. He tells about the horror of her loss, and the metaphoric leaves that blew on their frozen ground. It's an important book, one that I could not find, despite desperate efforts, when I searched high and low for comfort and answers over a decade ago. No one had yet written that book. It exists now.
Pastor Lusko has achieved great things for God. He determined at a young age to take risks for God, and those risks have resulted in tremendous fruit as his churches and ministries have thrived. Through The Eyes of A Lion reflects his unique integration of culture into his teachings. References from Starbucks to Broadway shows and Disney movies are used in illustrations with biblical tie-ins. His writing is vulnerable, perceptive and securely anchored in Truth.
Many of Pastor Lusko's experiences surrounding the loss of his daughter, Lenya "Lion" were similar to mine as we walked through the trauma and devastation of a child torn from our lives without warning. He describes death in it's full brutality, and pulls God into the heart-wrenching grief process. He doesn't sugarcoat death with platitudes. Just as my interest in the reality of heaven became utmost in my mind after our son's death, Pastor Lusko was drawn to what Scripture, and many other sources studying Scripture, said about heaven. The book explains and teaches the theology that comforted and challenged him.
I was surprised and encouraged by the turn that Through The Eyes of A Lion took after so many stories about loss, and survival through it, were told. Pastor Lusko stopped looking back and began to be concerned that we all look ahead. His theme, which started out as "You, too, can survive, and even spiritually thrive, through trauma" extended to "…and be prepared and able to do the unique things that God is calling you to do as a result of, not in spite of, your loss." Wow.
This book is honest, and you see that your struggles and pain aren't unique, that others have walked the convoluted, feet-knocked-from-beneath-you path.
This is the book that assures you that you aren't alone in your grief. It's 194 pages of easy-to-read, 2 Corinthians 3 comfort. It empowers you to make your pain count, too. It's honest, and you see that your struggles and pain aren't unique, that others have walked the convoluted, feet-knocked-from-beneath-you path.
Levi Lusko validates your pain and longs for your comfort as he knows what it was like to receive his.
This book assures us that God is there. When the sting of the cruelty of loss burns your heart as you see those around you relishing their blessings, and you ache over empty arms, He is near. Levi Lusko validates your pain and longs for your comfort as he knows what it was like to receive his. It scrapes the bottom, it's so thorough in relating the bone-reaching completeness of grief.
As importantly, it reaches up and pulls down grace and hope, promising that God loves, because it's author knows this first-hand. It offers a future with purpose of infinite importance. After you read this book, keep it accessible to share. Buy a copy to give. It's that important.
Thank you, God, for Through The Eyes of A Lion, a story born of pain that took God-given courage to write. May it comfort and encourage many who are stumbling in the darkness of trauma and loss, that they may get back up and live in your comfort and find purpose, for Your Kingdom. Amen.


text:
Q: Jsoup isn't parsing all the threads on reddit (only first 7) I'm trying to parse https://www.reddit.com/r/buildapcsales/top/
Url url = new Url(textFilePath.getFilereader());
Document doc = Jsoup.connect(url.toString()).get();
Elements threadTitle = doc.select("h3._eYtD2XCVieq6emjKBH3m");


So much for Obamacare making health insurance more affordable – analysts have firmly established that insurance premiums, especially for young Americans, are rising. Obamacare will increase the cost of premiums by an average of 44 percent for young females and 91 percent for young males.
Obamacare has expanded government intervention into health care but done nothing to reduce the costs, leaving young people in quite a bind. What can be done to fix this problem and make health insurance more affordable for everyone?
Proponents of government-run health care claim that intervention into America's health care system is necessary because the free market doesn't provide quality and affordable care on its own. These same proponents neglect to mention that government intervention has long distorted the health care marketplace pre-Obamacare.
Instead of more of the same, let's reduce overzealous regulation of the health care marketplace to create more competition, innovation, and choice for all Americans.
When numerous companies have to compete with one another to win our business, they are incentivized to provide their goods or services for the lowest possible price at the highest possible quality. Decreasing regulation allows more businesses and products to make it to the marketplace and thus gives the consumer more options.
Unfortunately, the president's health care law does not address the underlying lack of competition and innovation that keeps costs so high and limits the quality of care Americans receive. Obamacare increases demand by forcing everyone to buy health insurance while doing nothing to increase supply. It's the perfect recipe for higher prices.
Under our current health care system, obtaining prosthetics can cost tens of thousands of dollars. Much of the blame for such high costs lies with government bureaucracy. It shouldn't have to take millions of dollars and the Food and Drug Administration's (FDA) approval to make a quality, safe, and affordable medical product.
Leon McCarthy, a 12-year-old boy in need of a prosthetic hand, couldn't afford $30,000 for the existing prosthetic product. Instead, Leon's father, Paul, worked with an international team that included a puppeteer and a carpenter and built a $150 3-D printed prosthetic.
It's now available online in a newer design with parts as cheap as $5! This is a prime example of the sort of innovation that everyday people can come up with to solve medical challenges at low cost. Sadly, FDA red tape makes many innovations needlessly expensive and time-consuming, depriving all Americans of a greater supply of useful medical treatments. If Obamacare proponents are serious about reducing the cost of quality health care, they should address the overregulation of medical technology.
But that's not the only way the government limits the supply of health care. The government should be encouraging doctors to open new clinics and hospitals and welcoming the prospect of new options and lower costs for American patients. But Certificates of Need (CON), essentially government permission slips allowing would-be health care providers to operate, make it more difficult for doctors to expand the supply of medical practices. These certificates effectively serve to protect the profit margins of existing hospitals from new competition at the expense of patients. This needs to change.
If our goal is to make health care affordable for every American, increasing the supply of medical care is the best way to meet that goal. Obamacare has increased the demand for health care by forcing every American to buy it but failed to increase the supply. Hence, individual premiums are growing out of control.
Unless the government allows the free market to expand supply and stimulate competition and choice, American health care patients will be stuck with the same expensive treatments at the same expensive hospitals and face years upon years of rising costs.Obamacare only makes a bad situation worse.


The writer's craft as you read will not just result in a far better analytical essay. The moment the writer is appointed, they begin working on your essay based on the requirements you have specified in your purchase. Thus, you can choose a writer from a specific city of America.
If you are not pleased with any part of your completed sample essay, you are able to request a complimentary revision. The primary purpose of introduction is to allow it to be clear what you will write in your essay. There's rewriting, which is very good if you want an existent piece rewritten so you may use it in your studies.
If you've got a writing assignment, we can assist! It is so important, so here's what you can do to help your child write great https://telobox.hu/ ones! English class english essay ought to have an argument.
After you set the order, it is going to be forwarded to an available writer from the team. The professional writers who work here are always prepared to tend to your wants and meet all your demands. The group of our writers has the capability to cope up with the provided deadlines irrespective of complex requirements.
Now you've found the site of the very best essay writing service, you can order your paper with no concerns. So just in case the moment you consider the job of essay writer to be somewhat odd for you personally, make your venture, we've been the following that may provide help. Responsible and dependable essay writing company will do as per your requirements and demands.
Reasons of your decision could be different, but the point is. People these days have a propensity to go for a range of themes of that they are and endeavor to describe all of these. You may even need to compose a creative essay as a way to enter a Literature competition or maybe to land the job of your dreams.
Get things done more efficiently so that you don't need to sleep so late. When it is neglected, the pain increases. Each figure and table begins on the website that's new.
Ultimately, however, remember that excellent writing doesn't happen by accident. Very good writing solutions, including the ones I discussed above will be in a position Get More Info to assist you with any part of your assignments. Therefore, if you're planning to go for our English essay writing service, then you ought to know that an expert will look after your writing task for you.
Our Quality Assurance department is a crucial portion of our equation, ensuring your work is of the highest quality possible. Org has a broad selection of subject areas. No cost services also have a plagiarism report together with the paper.
It is possible to learn on how best to compose essays to on our Blog too Despite we offer essay-writing service it's possible to read more information and learn to compose different forms of academic papers. It's extremely important to read carefully essay services reviews, because you wish to avoid low high quality services. The RushEssay essay service is a famous company since they are extremely very good at advertising.
All the work generated by our organization is original. If you are in doubt about where to begin, we'll be pleased to talk about the requirements of your business on you, and to provide suggestions on the best ways to use content to improve your company. The optimal solution would be to receive an amazing paper for a price tag you are able to afford.
The contemporary students want the up-to-date solutions. In Australia, the effects of the fantastic Australian gold rush continue to be apparent today. Others might contain inappropriate subject matter for a number of communities.
You will be able to leave a location under the concept for pictures if you're including any. Essay editing solutions, full edition, sample my everyday progress page lists some useful. There are a terrific many sites offering assistance with your assignments, but not one of them is able to match the expertise and caliber of A determined young fact http://www.rotaractcassino.org/ checker is all about to stir up trouble.
Ordering is easy, it's safe, it's anonymous, and it's fast. Essays are rather difficult to write, and you might not have the essential time or skills to write them. Moreover, Rush Essay is a global service that's the reason you can observe all prices in USD, AUD, GBP and EUR, which is a significant option when you own a charge card in another currency, instead of in USD.
You will receive an email notification with a link where you are able to log into the website and securely download it. Concentrate on the topic is extremely important. Transportation in the calendar year 2050 english.


The Force has come to Tagoria W4. The Jedi Order are seeking out force sensitive Jedi to recruit into the ranks of the newly formed Jedi Order. We are currently accepting all members but preferably people at level 20 or above. The Jedi Order stand for Justice, Strength and Honour.
can use the healing ground to regenerate 100% of their health within 30 min after battle.