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Vaxxas moves towards pilot line, Covid clinical trials
Analysis and Commentary
Vaxxas moves towards pilot line,…
Vaxxas has long been viewed as an Australian medtech company with a great amount of promise.
The University of Queensland spinout was formed in 2011 to commercialise a needle micro-array concept used to painlessly administer vaccines, developed by Professor Mark Kendall — a rocket-scientist-turned-medical device inventor — and his team.
According to Vaxxas, the concept takes advantage of the high amount of immune cells in skin, meaning six times the response of antibodies for a given dose. Other selling points for its under-development HD-MAP delivery platform (formerly known as Nanopatch) include the possibility of self-administering dry vaccines by a patient, meaning lower costs, and fewer requirements around a cold chain and training to deliver medicine.
@AuManufacturing spoke to Dr Angus Foster, the company's Chief Development and Operations Manager, about the continuing journey to volume production for this Australian invention, new facilities for the company, Covid-19-related R&D, and upcoming clinical trials at the Sunshine Coast.
@AuManufacturing: It seems to have been an eventful couple of weeks, with the Translational Research Institute expansion funding announcement and the results that you've got some coverage for.
We've been based at the TRI since about 2015. We moved Vaxxas operations across here from University of Queensland and I think, as we discussed previously, we needed to access the clean rooms that are needed for manufacturing products, for early stage clinical studies — phase one studies. We've been using the clean rooms, labs and offices here since that time. It's helped us build the datasets and publish clinical studies and prove the concept, if you like, from an immunology perspective.
We were very fortunate, last year there was support from the Queensland state government for our next facility. It's still on track. This is the Northshore R&D manufacturing hub for Vaxxas. We aim to move in there midway through next year. It's got offices for about 150 people with about 70 there at the moment. It gives us some room to continue to expand, allows us to take our laboratory operations, R&D work across there. And also really importantly, I think as we discussed last time, the aim would be to get the TGA in to review the manufacturing and laboratory facility, to make sure that it's fit for manufacture and supply of material into later-stage clinical studies. There's a couple of large clean rooms that are going into the facility. That would enable us to make products for phase two, potentially phase three, and even potentially early-stage commercial supplies if it made sense to do that. So that's obviously on the vaccine/product combination, then on the device side, on the applicator or the patch itself, it's got space for sort of manufacturing activities: injection moulding and device manufacture as well. So we could make devices from that facility, which would then potentially be sold to partner companies who are putting the vaccine onto that combination and taking it to market.
It's been purpose-built for us. We helped design it. We're involved in the specification, the build, the layout, and obviously making sure we've got expertise involved, and it was going to meet the requirements of the pharmaceutical manufacturing facility for the vaccines.
Then the TMI as well. One of the reasons we're going into this new facility is I think where we are now is not suited to the next stage of development. For the Queensland state government to recognise that gap and support another facility, where space can be leased, companies can go into, as they come out of the TRI and take a product through to later stage studies, build value and grow those businesses here in Australia, I think is really exciting. So I think it's good to be associated with it.
@AuManufacturing: That is where you will be commissioning the pilot line you announced last year?
Yes. The new manufacturing pilot line, which will be used to make products to go into phase three studies, will go into the Vaxxas Northshore facility and enable us to produce products with a process that is very, very similar to the final commercial process.
The timing for that? We're still sort of designing the pilot line. And there is still a bit of a funding gap. The facility is the facility, but the pilot line itself is not a cheap piece of equipment to design, build and validate. So it's probably around $15 million Australian dollars for that pilot line. So we're looking for potential partners to help fund that as well, whether that's pharma, philanthropic or even government funding opportunities to get that line up as soon as possible. That's the next stage.
@AuManufacturing: You mentioned last time that the TRI would be unsuited to the next phase of clinical trials.
That's right. It's just not set up for that type of thing. It's great to have a purpose-built facility, but the TMI facilities for the drug substance, for the manufacturing of vaccines, I think will be really well-suited for those types of scaled up operations.
The other news is that we had some research out of University of Queensland with our technology, with Dr David Muller's research on a Covid-19 vaccine candidate, Hexapro, the spike protein. We got some great data in a preclinical model showing that there's the potential in a model to get decent antibody responses after one dose. Especially if you combine the Hexapro with an adjuvant, which sort of increases immunogenicity of the vaccine. And he also showed that it was generating antibody neutralising responses against different variants of the sars-cov-2 virus as well, which is very topical at the moment. Then he took it into a study where he looked at the protective effect and that same model. So preventing infection of the animals through use of that vaccine, and got some really strong data in that model, showing complete protection of the animals to exposure to a variety of different variants, after two doses with or without the adjuvant. So it's a lovely set of what you call early-stage preclinical data, showing the patch may have a real role to play in improving responses to covid-19 vaccine. He compared the performance with the patch technology versus injection by intradermal application, which is just an injection just underneath the skin. And the patch performed much, much better than the ID injection in the study in the studies he ran.
For us it means that we'd like to look to fund that and turn it into a clinical program. I guess if it was a single dose and you combine that with potentially all the benefits of a patch to deliver the technology — ease of use, hopefully thermal stability, possibly getting around some of these challenges we've got in storage of the MRNA vaccines. And he got good data — I think he went out to at least at least a week and 40 degrees centigrade and got good recovery of that spike protein in that period of time.
That's really encouraging for a pretty small study.
@AuManufacturing: How long would the gap be between that and clinical trials at the different phases?
Depending on the approach that we take, it could be in the clinic within a year or so. It depends on the funding into the program. That's one great thing about Australia is the clinical trial notification procedure for first-time in-human studies does simplify that clinical process. So we'd like to think we could be in the clinic within a year and generating data.
Then from that point, it's hard to predict really how long it takes you to get to market. We've been driven by the scalability of our technology and how that would sit within that scenario. But having seen the rapid authorisation or emergency use authorisation of vaccines around the world for Covid over the past 12 months, you could move pretty quickly through the clinical program. As long as the technology was at a scale which could be progressed at that pace as well. I think that would be our challenge.
@AuManufacturing: I have heard others say that getting into clinical trials in Australia is comparatively smooth, but manufacturing for clinical application is the really difficult bit. Has that been your experience?
Yeah, that's why we do it ourselves! And why we moved into TRI and got started doing our own manufacturing, there was no way of really finding a CMO [contract manufacturing organisation] in Australia that could do that work. And right back in 2012, 2013, we're looking at potential CMOs in Australia to do the specialist activities needed to produce materials for phase one studies. There are a couple of small, small companies. They could have potentially done it, but it wouldn't have been easy. We're a bit of a unique example because of the specific technology we need to manufacture our products. But I think our challenge remains, even if you're trying to produce a liquid in a vial for needle and syringe administration, where do you do that? Where do you scale up your vaccine or drug substance manufacturing to make it suitable for use in clinical studies and meet all the requirements that you need to do to do that? I think that is a gap and why things like investment in the TMI, I think that's where it helps get into that process of being able to do that.
I think the other gap is making sure we have a workforce capability to do those manufacturing activities. For example, here we work with the TRI, with some of the researchers in the building, train them in Good Manufacturing Practice, they help run our cleanroom operations, help produce clinical batches and just give researchers exposure to what it takes to produce products that we need to go to clinical studies, and the level of quality oversight, documentation and process development you need to do so.
I think there's been a gap. And I think that's where obviously the government can play a role in helping foster that for companies and groups to be able to move into that area. Because it's difficult recruiting people into Vaxxas that have good vaccine development experience. There are a lot of very, very capable young scientists, engineers and researchers coming out of universities all throughout Australia but really there is a gap in terms of people having a good industry experience and know what they need to do when they join a company and start working in a different type of environment.
@AuManufacturing: What other clinical work are you focussed on at the moment?
We have got one that was in the media a week or so ago, which has been run up at the Sunshine Coast University Clinical Trials centre. That's a study we're doing with the measles and rubella vaccine. That vaccine is widely available to people in Australia, but still getting people access to that in some parts of the world is still very challenging for reasons of cold chain complexity and skilled healthcare workers to administer it. This is an opportunity to participate in a clinical trial which can really ultimately improve access to a vaccine for low and middle income countries. That study is starting its recruiting at the moment at the USC clinical centre. We are trying in a short period of time to get as many people in.
Picture: Vaxxas
By Brent Balinski June 15, 2021
Author: Brent Balinski
Brent is a co-founder and editor of @AuManufacturing.
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text:
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Nov 2, 2022 | Gibson
NEW ARRIVAL For those who want the look and feel of a Gibson jumbo, but don't wan't the brightness of Maple back and sides found on a J200, the J100 is a great alternative. It features a solid Sitka spruce top with Mahogany back and sides, which deliver a thundering bottom end and a warm midrange response. A slightly stripped down version of it's famous cousin, the J100 still retains the elegance, class, and power of Gibson's Super Jumbo acoustics. Also as a 100th anniversary guitar, it's very desirable, and a future collectable. The guitar's in good condition, with plenty of lacquer checking, a great feel and comfortable neck and action. It comes in it's original Gibson embossed tan hard case.


text:
import unittest
import numpy as np
from aston.trace import Trace
from aston.peak import Peak, PeakComponent

class TestBoxPeak(unittest.TestCase):
    def setUp(self):
        # box peak
        info = {}
        trace = Trace(np.ones(10), np.arange(10), name=1)
        baseline = Trace([0, 9], [0, 0], name=1)
        c = PeakComponent(info, trace, baseline)
        self.peak = Peak('box', components=c)

    def test_area(self):
        assert self.peak.area() == self.peak.area(1)

class TestGaussianPeak(TestBoxPeak):
    def setUp(self):
        # box peak
        info = {}
        v = [0.043, 0.067, 0.094, 0.117, 0.131,
             0.131, 0.117, 0.094, 0.067, 0.043]
        trace = Trace(v, np.arange(10), name=1)
        baseline = Trace([0, 9], [0, 0], name=1)
        c = PeakComponent(info, trace, baseline)
        self.peak = Peak('gaussian', components=c)

redpajama_set_name: RedPajamaGithub


text:
Mainers get ready for Earl: Local marinas pull vessels out of harm's way
Camden's Windjammer Festival will get a late start, while high school sports officials reschedule games.
By Melanie CreamerStaff Writer
PORTLAND – Cameron McLellan moved the patio furniture off his dock at DiMillo's Marina on Thursday morning and secured it to a net on his 63-foot catamaran.
As workers loosened the bolts holding his dock to the marina, McLellan stowed the lawn mower he uses to cut the patch of grass at the end of his dock. He is sailing to safer waters in The Basin in Phippsburg today.
Portland Yacht Services' Jason Phippen and Matt Ridgeway assist in taking out their 50th boat Thursday ahead of Hurricane Earl. John Patriquin/Staff Photographer
Avoiding Earl, cruise shipsarrive early in Portland
Earl to reach Gulf of Maine by midnight
Acadia park to close roads, campgrounds
Earl sideswipes NC, takes aim at New England
Storm sends some fleeing Isle of Shoals
"Don't let my grass get too much sea spray," McLellan said just before the workers moved his dock to a safer place in the marina.
Marinas and boat owners began hauling vessels from the water and securing docks Thursday in preparation for a brush with Hurricane Earl this weekend.
And with the storm moving up the East Coast, events in Maine such as Camden's Windjammer Festival and some high school sports were rescheduled as a precaution.
Portland Yacht Services, at the mouth of the Fore River, planned to haul out about 100 boats in anticipation of the storm. Phineas Sprague, president of the marina, ordered the emergency haul-out Wednesday.
"The issue isn't the hurricane, but the associated wind out of the northeast," Sprague said. "Our marina is not set up well to protect the boats in northeast winds. It's an unfortunate wind direction of significant velocity. The alternative (to taking boats out) would be a disaster."
DiMillo's Marina advised its customers to take their boats out of the water or go to a "hurricane hole," such as Quahog Bay in Harpswell, an area that's protected from the surf and swells that storms can generate.
About 25 boat owners at DiMillo's decided to pull their boats out. The marina is not accepting transients.
"If the storm stays what it is right now, it won't be a big deal for us," Chris DiMillo, an owner of the marina, said Thursday. "But you never know what is going to happen. You don't know which way it will shift or what the wind speeds will be."
South Port Marine in South Portland, widely considered one of the most protected marinas in the Portland area, planned to haul about 30 boats from the water.
Handy Boat Service in Falmouth, one of the least protected marinas, decided not to haul any boats.
Jay Hallett, general manager of the marina, predicted the storm will pass 130 miles east of the marina, so quickly that the seas won't have time to build up and damage boats or marinas.
"We're really too far from the center of the storm for it to affect us," he said.
The National Weather Service in Gray issued a tropical storm watch early Thursday.
Mike Cempa, a meteorologist for the weather service, said Mainers can expect wind gusts reaching 30 mph tonight into early Saturday.
"If the storm stays on its current track, it could nearly miss the area," he said. "It's going to go too far east to bring us true tropical storm effects. There is still some chance that it will move west and produce stronger winds. We don't want people to think it's safe just yet."
Organizers of the Camden Windjammer Festival decided Wednesday to cancel today's events and delay the start of the festival until 4 p.m. Saturday. The festival will last until 9 p.m. Sunday.
"The last thing we want to do, as a community, is throw a party that will bring thousands of people here when there is a risk of a hurricane moving through the area," said Dan Bookham, executive director of the Camden Rockport Lincolnville Chamber of Commerce. "We thought we would err on the side of caution."
Anticipating Hurricane Earl's possible effects, some Maine high schools moved season-opening football games from Saturday afternoon to today. Thornton Academy and Cheverus High School moved their home football games to 1 p.m. today, while a few games scheduled for 7 tonight will start one hour earlier.
Central Maine Power Co. has increased its work force in preparation for possible power outages early Saturday. It also has arranged to hire contractors to provide line and tree crews.
The York County Emergency Management Agency is advising people to pay attention to weather forecasts and plan for evacuations and power outages.
Staff Writer Melanie Creamer can be contacted at 791-6361 or at:


1) Implemented current WFRP Insanity rules. Any arcane spellcaster that learns spells from more than one Lore of Magic (i.e. Wizard, Witch, Gypsy Nomad) gains 1d3 Insanity Points each time they level. Necromancers, Daemonologists, and Chaos Sorcerers do as well. If any character gains enough insanity points that they gain some mental condition, I'll simplify the WFRP rules a bit to make a chart more in the vein of MikeInside's Insanity rules.
Explanation: Even if my player is a standard Wizard, casting spells per the normal rules, magic cannot be so inconsequential as the constant Healing Hands we are used to. So, for example, Quasar the 2nd level Wizard casts Healing Hands from his allotment of power as normal. However, he rolls 2d10 because if he were to roll double ones his spell would fail and he would gain an Insanity Point! If he rolls doubles of any other sort the Curse of Tzeentch takes effect and even though the Healing Hands spell works properly some unsought after effect may also come through the warp!
Extra dice rolling I'm afraid but I just don't want magic taken for granted any more! I thought hard about converting their spell system to WHQ's d6-based casting and turning Wizards into luck-based casters like the Ranger Mage, but it just wouldn't work. With six-siders, there would be far too many spell failures and Curse of Tzeentch rolls.
1) In every other RP game, it takes time to cast spells, but in WHQ the Wizard can cast as MANY spells per Turn as he wants! It is never fair to the other Warriors after level 1 either. So, should I limit how many spells Wizards can cast per round like the Ranger Mage and Warrior Priest? Or should I go through each spell and detail a casting time?
2) Speaking of which, I am really wishing I had more time and energy to work on stuff, because I really would like to write a Tome of Magic similar to the one written for the Magus character. Basically, I want to map out an ultimate spell list, detailing EVERY spell from the first WHQ book as well as every other spell I've ever thought of giving to a character. Even the different names that differing schools of magic have for the same spells would be detailed! I want to include casting times (in case I implement them), spell ingredients (if casters use ingredients they would get either Power discount or a + to their casting roll), and I'd detail how much power the spell would cost for a Wizard-type and what the casting roll would be for a luck-based caster.
I am talking a HUGE grimoire here because I tend to include spells from D&D, Mongoose D&D supplements, WFRP, Mordheim, and Warhammer Fantasy Battle.
Since this was in his personal thread, I thought it would be best to make it a separate thread together with some ideas of my own (I like some of his suggestions, but I don't think we should drop the d6 just for magic).
I would also like to limit the casting somehow, and maybe it would be best to link it to the attacks of the Wizard. He can cast one spell instead of an attack. If he gains somehow more attacks than he usually has on his profile (other than granted by weapons of course), he can also use these as spells. This is to keep the Wizard from hoarding his Powertokens and then unleash hell in the Objective Room, clearing it out in one turn.
Example: A lvl 2 wizard has 1 attack, thus 1 spell he can cast instead. If he drinks a Potion of Combat from the Wizard Guild he gains +1 attack, so he can either attack twice, attack once and cast 1 spell, or cast 2 spells.
As I said before, attacks granted by weapons don't count (so a Sword of Leaping Gold which gives +3 attacks, if I remember correctly, doesn't give 3 spell opportunities). Of course, to use these extra attacks, he must attack normally at least once.
Now for casting, the Wizard says which spell he wants to cast, rolls a die and adds his battle level to it. If it exceeds the required number to cast, he can cast it. If not, he fails. A 1 is an automatic failure (but I think a 6 being an automatic success is a bit too much). If he can cast another spell, he rolls a die for that, adds his battle level, but subtracts the amount of mana needed to cast any previous spells.
If he fails to cast a spell, he can use Powertokens to change the difference to succeed anyway.
If he rolls the same number as the die in the Power Fase, the spell works, even if failed, because Tzeentch witnessed the attempt and favoured him. He receives however 1d3 insanity points.
Now an example to clarify all this: again the lvl 2 Wizard, this time casting a Fireball. This is a level 5 spell, so he must roll at least a 3 to suceed. A lvl 5 Wizard has 2 attacks, and can cast 2 spells. His first is a Fireball. He adds 5 to the die roll, but with 1 being a failure, he has to roll at least 2. Then he tries to cast a Heal Wounds (a level 4 spell). Since he has used a level 5 spell before, he lowers his battle level with 5, meaning he has to roll 4 or more to cast it. Unfortunately, he rolls a 3 (not enough to cast it), but he uses 1 Powertoken to make it a 4 so the spell works anyway. If a 3 had been rolled in the Power Fase, the spell would have been successful as well, but he would have gained 1d3 insanity points.
I would also include "spontaneous casting". He can cast 1 extra spell per turn (no attack needed for this one), but at twice the level. So, if he has used up all his attacks at the end of the turn, and one of his comrades is bleeding to death, he can try to cast a Healing Hands for 4 instead of the normal 2.
2) I was thinking of making the Powertokens more important, allowing to use them to pump the effect of the spells. Example: You use a Fireball and use an extra 3 Powertokens to cast it (so, not making the spell cost 8, but still 5 and paying an extra 3 Powertokens), it now does 1d6 + the battlelevel of the wizard + 3. I am considering though to make this for the damage of the spells only (so with a Freeze you do 1d6 + x damage to that 1d6 enemies, and also not healing each warrior 1 + X wounds with a Healing Hands).
Now, some of your ideas are very good, however I am still not sure to what extent the casts per Turn should be limited. The game as it is now, the Wizard at Battle-level 4 sometimes can make 2 Attacks and cast literally 10 spells in a single Turn. Clearly that's too much (unless the rest of the party likes sitting back and watching the one player go), but the party depends on this for survival (thus the crack addiction analogy). So if the Wizard is toned down as drastically as you suggest the Monsters can't come near as fast and furious. That's why I'm implementing the 1d10 for Random Events and such in my own game (and I'm not even limiting casting as much as you suggest)- the current game is fast and furious hackfest with the Wizard as engine and if that engine is stripped down with no change in the environment things will get ugly fast.
I will stay tuned because I'm curious what everyone else thinks about the spells per Turn (or if it should vary by spell) as I have not made up my mind on this.
Of course, the casting per turn is just a first draft. I'm open for suggestions.
And of course I realise that a Wizard like this won't survive long in the environment an "old school" Wizard hangs around, but then again, seeing as the Bestiary has to be rewritten too (to take out obsolete and/or old critters) it's a logic step to redo the Monstertables too. For the moment the Monstertable is broken (not as much as some other parts of the game), and if we tune our attempts to fix things to something broken, it'll get worse than the start. The warriors are the most important here, so we should look at them without the monsters. And when the warriors are up to date, then we can focus on the monsters and see how they turn out.


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Home / _Television / Jessica-Jones / krysten-ritter / netflix / television / 10 Things To Know About AKA JESSICA JONES
10 Things To Know About AKA JESSICA JONES
Nigel G Mitchell 12/10/2014 06:24:00 PM _Television, Jessica-Jones, krysten-ritter, netflix, television
Krysten Ritter; Source: AP/Marvel
With the announcement of Krysten Ritter playing Jessica Jones in the Netflix series AKA Jessica Jones, many in the media asked, "Who's Jessica Jones?" She's one of four Marvel characters that Netflix bought the TV rights for, so with production starting soon, let's deep dive into who she is and why you should be excited about the TV series.
1. Jessica Jones first appeared in the comic book series Alias in 2001 (no relation to the TV show), and ran for twenty-eight issues under Marvel's mature MAX imprint.
2. At the time of comic's publication (and presumably the TV series), Jessica Jones is a superheroine who retired from crimefighting to pursue a new career as a private detective.
3. Jones gained superpowers after a car accident with a military convoy doused her with radioactive chemicals, granting her superstrength, flight, and a limited resistance to damage.
Source: Marvel
4. Jones fought crime as a low-level superhero nicknamed Jewel until the supervillain Purple Man used his mind control to turn her into his slave. After months of servitude, Jones was finally freed, but the experience left her traumatized.
5. The PTSD from her Purple Man encounter caused Jones to quit her life as a superhero. The experience also caused her to stop flying altogether, seemingly having lost the ability.
6. As a private detective, Jones takes on cases involving superheroes and supervillains, even though she refuses to put on her costume again.
7. In the comics, Jones struck up a friendship and falls in love with Luke Cage. They were married and have a child together named Danielle. Reportedly, her romantic story arc will be picked up in the TV show.
8. Jones also briefly took on a job with The Daily Bugle as a superhero correspondent for the newspaper supplement Pulse. We're not sure if that will happen in the show.
9. Given the back story, we expect part of the reason Netflix took on the series is that her lost powers and identity will make it cheap to produce. In the comics, Jones eventually regained her power of flight, but we don't think that will happen in the show.
10. In the comic series, Jones briefly returned to her superhero identity as Jewel. No word on whether that will happen on the TV show.
11. The original comic series dealt with the emotional journey of Jones trying to heal and help others. If the TV show followed that pattern, it would be a very different portrayal of a superhero.
12. The original Jones comic series dealt frankly with sex and violence. Jones used adult language, smoked, and drank. Since this is the same network that brought you House of Cards, we might see the same in the TV series.
What do you think of Jessica Jones?
That does sound interesting. I probably have seen her in some Marvel stories but didn't really notice. In an Ultimates story there seemed like there was a character like her but she was black. Maybe it was the same one?
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Bayern Munich enter race for Liverpool target with £106m release clause
Thomas Hein
Liverpool face competition from Bayern Munich for Portuguese sensation Joao Felix, according to Bild (h/t Metro). The 19-year-old has been in sensational form for Benfica, scoring 5 goals in 12 games. The report adds that Liverpool saw a £61million bid rejected while the youngster has a release clause of £106million.
The report adds that Bayern see the 19-year-old as an alternative to Chelsea's Callum Hudson-Odoi. The Chelsea youngster submitted a transfer request in hopes of sealing a move to the Bundesliga champions and even rejected a new deal with the Blues (h/t Metro).
The report adds that Manchester United, Atletico Madrid, Borussia Dortmund, Barcelona and Lyon are all keeping tabs on Felix.
The Reds aren't averse to spending big when they need to. Alisson, Virgil van Dijk, Fabinho and Naby Keita have all been signed for huge sums and it is to be seen what transpires regarding the 19-year-old Benfica star.
Liverpool didn't make any signings in the winter window and sold Dominic Solanke to Bournemouth. The Reds have a couple of young attackers doing well on loan.
Harry Wilson has been a star at Derby County while Ryan Kent hasn't done a bad job under Steven Gerrard at Rangers.
Read more: Ligue 1 club's former employee claims they are looking to sign out of favour Liverpool star on loan
It would be great to have more attacking options for the coming season and hopefully, we get to see some of these starlets perform in the first-team at Anfield.
Related Topics:Joao FelixLiverpoolTransfer Rumours
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A massive Liverpool fan with a twisted sense of humour, guess that's what supporting the Reds does to you. Left behind the corporate world to set up The Kop Times


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Two days back, I have received an email with PDF file attachment. When I tried to open PDF file, it shows an error message which says: "format error: not a PDF or corrupted"
I was surprised to see such error message and thought hope it was not a virus file as attached PDF. Immediately I have called to my friend who is expert in handling PDF file error matters. My friend suggested me it may not be virus file. It could be possible that PDF file got corrupted so he suggested me to open PDF file in foxit PDF reader which is an alternative of adobe reader then I install the foxit pdf reader, & try to open "corrupt" pdf files.
Did you try to save it to some place and then open it?
Some PDFs created by third-party software may look corrupt when these files are opened as attachments, but if you open this file as standalone PDF file, this is all OK.
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Missing boy found safe protected by his "Buddy"
Updated: 3:44 PM PST Feb 20, 2020
all right. A pit bull in Live Oak, Florida being hailed a hero for protecting his lost owner until rescuers showed up. Check out this story. According to the Swanee County Sheriff's Office, Buddy the dog helped police locate a missing three year old boy who had wandered off into the woods on Tuesday. Authorities were first made aware of the boy's disappearance when his mother frantically called 911 and reported that the child was missing along with that family dog he apparently had been playing outside with the siblings, Officers and a canine unit began searching for the missing boy until they received a call from a neighbor that the child had been found on body cam footage. But he could be seen leading deputies to the missing boy when they arrive on scene. Sheriff Sam ST John told the local news outlet that it was such a good ending to something that could have been tragic. He said, quote, We're all the time putting out tragic news. I'm telling you, it feel so good, so good to tell a good story. Police said the family is doing well and that the child was not hurt in that ordeal. Glad it ended so well. And it's It's one of those things and we're talking about a pet love your pet day. But how? Family dogs, especially, are so, like such great they really are members of the van. Yeah, I hope that dog gets a little extra love today on this special day for him.
Police were able to reunite a 3-year-old boy with his mother Tuesday, thanks in part to his best friend protecting him during his afternoon adventure.The Suwannee County Sheriff's Office in Florida received a 911 call from the boy's mother, who worriedly told them her son and family dog were both missing. The boy had been playing with his siblings, but at some point had wandered off on his own. She assumed the dog, Buddy, was out with the boy somewhere.After searching for some time, a nearby neighbor called the police, saying he saw a small child and dog in the woods. He had tried to approach them, but the boy's loyal dog wouldn't let a stranger get near the child.Responding to this, the police were able to locate the pair and reunite them with their family.
SUWANNEE COUNTY, Fla. —
Police were able to reunite a 3-year-old boy with his mother Tuesday, thanks in part to his best friend protecting him during his afternoon adventure.
The Suwannee County Sheriff's Office in Florida received a 911 call from the boy's mother, who worriedly told them her son and family dog were both missing. The boy had been playing with his siblings, but at some point had wandered off on his own. She assumed the dog, Buddy, was out with the boy somewhere.
After searching for some time, a nearby neighbor called the police, saying he saw a small child and dog in the woods. He had tried to approach them, but the boy's loyal dog wouldn't let a stranger get near the child.
Responding to this, the police were able to locate the pair and reunite them with their family.


The film got into controversy for allegedly hurting Hindu sentiments and promoting 'love-jihad' from the beginning of its shooting.
Sara Ali Khan says she was disappointed that she couldn't share her labour of love, her debut film "Kedarnath", with the people of Uttarakhand — the state where she started her journey as an actress.
During an interaction with the media here, Sara was asked how she reacted when the film failed to get a release in Uttarakhand due to objections from some sections over the alleged promotion of 'love jihad' in the film.
Set in the hill station of Uttarakhand, the story of the film revolves around a Hindu girl falling in love with a Muslim boy and the societal opposition due to their different religions. It is set against the backdrop of a natural calamity.
Before the release of the film on December 7, the Uttarakhand government wrote to all district magistrates about the film and the controversies surrounding it.
The government asked the district administration to take a call on their own and left it to their discretion whether or not the film should be released in their respective jurisdictions. So, the film did not release in the state.
Directed by Abhishek Kapoor, the film also features Sushant Singh Rajput.
Sara's maiden performance won her a lot of praise from critics, the audience and her parents — actors Amrita Singh and Saif Ali Khan — as well as the Hindi film fraternity at large.


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Maikaba waits on NFF for Flying Eagles coaching job
By Alex Monye
23 April 2020 | 4:13 am
Plateau United Coach, Abdu Maikaba, has disclosed that he is not aware that the Nigeria Football Federation (NFF) has concluded plans to make him the new head coach of the National U-20 team.
Maikaba
Recently, some media outlets reported that the former Kano Pillars coach was in line to be announced as the new coach of the Flying Eagles.
Maikaba told The Guardian yesterday that he was pleasantly surprised when he heard the news, adding, however, that nobody from the NFF has officially contacted him on the appointment.
He said he was currently working on ensuring that Plateau United won the Nigerian Professional Football League (NPFL) at the end of the season, adding that the Jos-based team have the personnel top accomplish the feat.
"I applied for the job, but the NFF has not officially told me that I have been chosen as the new coach of the Flying Eagles.
"It will be a thing of joy for me to coach the national U-20 team because of my vast experience working with young players from the grassroots. My target is to win the NPFL, which I have not won before as a coach. That is why I am working with players that are hungry like me to achieve the feat," he said.
Abdu Maikaba
Plateau United
Peace in Nigerian sports – Going back to the future
Nigerians are tired and frustrated with the unending crisis in some national Sports Federations. The particular case of the Nigeria Basketball Federation has compounded the situation as the Ministry of Youth and Sports, frustrated by the endless crisis, took a desperate decision that appears to have added salt to the injury.
Enyimba highest ranked Nigerian side as North Africans dominate CAF top 50 ranking
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Abductors of former Secretary of Nigeria Football Federation (NFF), Sani Toro; former Assistant Coach of the Super Eagles, Garba Yila and one of their friends, Isa Jah are demanding
Buhari orders NFF to hold elections in September, amend statutes
President Muhammadu Buhari has directed the Nigeria Football Federation (NFF) to immediately commence the process that will lead to holding new elections into its Executive Committee at the expiration of the current administration in September. The Nigerian president also directed that the instrument of football administration in the country, the NFF Statutes, be amended to…
President Buhari directs NFF to amend statutes, hold elections in September
President Muhammadu Buhari, yesterday, directed the Nigeria Football Federation(NFF) to immediately commence the process that will lead to elections into its executive committee at the expiration of the current administration in September.


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