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LungDirect is Matrix Analytics' initial software application solution. Through patient management and clinical outcomes, our learning algorithms can analyze big data to present real time clinical decision support. And we're just getting started. Disease such as diabetes, asthma, and psychiatric disorders can all be positively impacted by our learning algorithms.
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I love working in my art journal because it's portable and since I mainly use fine tipped markers like Copics and Staedtler pens and my favorite art supply of all time....my Peerless watercolors, I don't have to carry much around with me. I made this while sitting on my couch watching a Grey's Anatomy marathon with a giant dog head in my lap. Now that's my kind of art!
Every year, my fabulous place of employment holds a Fall Fest for Halloween in the park that is in back of our building. This year was no different. The weather was beautiful, they had a costume contest, and lots of other games and activities. It was a nice afternoon break, and I left with $15 worth of Starbucks gift cards to use at a later date. Can't beat that!
At the center of the party was a huge table filled with Halloween treats. If you know anything about me, I can not resist sweets, especially if they have unnatural colored frosting and sprinkles. I tried to be good at the party though, because earlier that day we had a potluck which included all kinds of desserts as well. The last thing I needed was to consume another cupcake, but they just looked so beautiful! I thought maybe if I took pictures of them it would be enough to satisfy my craving. So here they are!
Are these not the cutest ghosts ever?
Mmm...black frosting. These should make your teeth and lips look nice!
Last week I went on a road trip to Phoenix for an event at the local ceramic distributor's warehouse called the Clay Olympics. Students and professional potters come to compete in contests like who can throw the widest or tallest pot, tandem throwing, throwing with one good hand and one hook (they had a pirate theme this year)....you get the picture. I was required to go for work (tough job I have :D ), where I set up a table and showed off our fabulous Duncan glazes to the attendees. It was a fun trip, but as usual I didn't schedule enough free time to visit with many of my friends from Phoenix, which is sad because I miss them!
Normally when I drive to Phoenix, I go from Fresno to LA, make a left and take the I-10 to Phoenix. It's a long, boring drive and I always get stuck in about 2 hours of traffic when I get to LA. This time I decided to take a different route, which brought me through some of Nevada and down from the northern part of AZ, through Flagstaff and Sedona. Although I ended up driving more miles, there was no traffic so it took about the same amount of time. Plus it was so scenic! I got to Sedona right when the sun was going down, so I had enough light to see the beautiful landscape that I miss so much. It really is a magical place. I was hoping to get there a little earlier so I could go to my favorite place in Red Rock State Park, a patio behind the visitor center where they set up about a dozen hummingbird feeders. The hummingbirds are all over the place, and they whiz past your head the whole time. I love it there. I could sit watching them for hours. Unfortunately, though, this time I missed it.


This is a super duper late post actually. I've been busy for the past few days posting about my fabulous contest. Last Mother's day, I covered MYMP's new album launching at Robinsons Ermita (read here) after the musical serenade, my husband invited me to have dinner to any restaurant I wanted. Since I haven't tried to eat at Mr. Choi Kitchen and I felt like eating Chinese Food that time I asked him to eat there.
I ordered a lot and we almost finished it all since we were already so hungry. All the food we ordered tasted good and it exceeded my expectations the only thing I am not satisfied was their service. Our food took almost 30 minutes or more to be served. I understand that it's Mothers day that is why they have lots of patrons that day, but they should have prepared for it right? They have few waiters to serve and take orders and because of that we even saw the cooks were already serving.
The fish fillet we ordered should have a sauce but then again it took a few minutes and a follow up to request for the sauce to come.
Our bill reached P1,000 and I learned that Good Housekeeping is giving away FREE loot bags if you billed P1,000 and above with selected restaurants including Mr. Choi. Unfortunately, when I asked the crew for it he said that the minimum amount should be P1,500 so I checked it again on the poster outside the restaurant.
It clearly stated the P1,000 bill so I asked other person and even showed my receipts for the Good Housekeeping bag. It is one of their perks and one of the reasons why we chose to dine there so I think I have the right to receive it.
Do you recommend this resto? I'm looking for a nice place to eat in kasi after graduation on May 31. 🙂 And Rob Ermita is a convenient place naman since PICC kami. Or is the place full lagi?
I recommend the foods, masarap naman talaga pero sana lang magbago yung service nila.
Good for ilan po yung isang order? Like the Yang Chow Fried Rice? Thanks.


text:
'I'm no apologist for China': National's Simon Bridges defends state TV interview
Watch: Simon Bridges was asked if he met with the head of China's "secret police". Credits: Newshub
Simon Bridges says he is "no apologist for China" in his defence of an interview he gave Chinese state media during his visit to the superpower.
The National leader's interview with state-owned news channel CGTN made world news. The Guardian highlighted how Bridges said he was "amazed" by China's prosperity.
When asked about his comments on Monday, Bridges told Magic Talk: "I'm no apologist for China, but I also think we've got an incredibly important relationship."
Simon Bridges rejects claim he met with China's head of 'secret police'
Anne-Marie Brady warns MPs of Xi Jinping's 'foreign-influence campaign'
Simon Bridges sings Communist Party's praises in interview with Chinese news channel CGTN
Bridges praised the Communist Party of China (CCP) for taking the country from mass poverty to economic prosperity in the state media interview, calling it an "amazing story".
He told Magic Talk a communist system is not something he would choose for New Zealand, but said it has "lifted hundreds and hundreds of millions of people out of poverty" in China.
"I think there are some really good things that have happened in China over the last 70 years... I obviously entirely disagree with them when it comes to issues of human rights," Bridges said.
"And by the way, in that interview, you've heard half of it. They took out half."
A spokesperson confirmed to Newsroom that had been the case but said there had been no tampering, and it was in line with standard New Zealand media practice.
Bridges also doubled down on his defence of meeting with Guo Shengkun who is responsible for China's Ministry of State Security (MSS), described as a combination of the CIA and FBI.
Canterbury University Professor Anne-Marie Brady, an expert on Chinese politics, tweeted about the meeting, describing Shengkun as "in charge of China's secret police".
Bridges pushed back on that description last week, saying it was an "unfair characterisation" of the man he met.
He told Magic Talk he "didn't know" about the "secret police" references to Shengkun "until it came out on Twitter".
He added: "That's obviously the Anne-Marie Brady version of life and events."
Brady has warned Parliament about the CCP's foreign interference agenda to bring the Chinese diaspora in New Zealand "under control".
Bridges said the main focus of the meeting with Shengkun was to discuss the relationship between China and New Zealand, such as trade and new opportunities.
He said he discussed areas of concern where he could, such as the tense relations between China and Hong Kong, and secretive camps in China's Xinjiang province reportedly holding Uyghurs and other Muslim minorities captive.
"Where I had the opportunities in meetings about Hong Kong, about Uyghurs, about these things to the extent they came up, I made quite clear we have an independent foreign policy," Bridges said.
"Sometimes we agree with the US, sometimes we agree with China, and we think rules of law and human rights and democratic norms are important.
Bridges said if New Zealand wants to continue to have prosperity, "we've got to trade" with China.
He said that doesn't make him an "apologist" for China, but it "does mean we have a mature and sensible relationship with China, with India, with the United States and other countries".
Bridges said the US-China trade war is the "single biggest issue in the world today" and New Zealand needs to figure out where it stands on it.

redpajama_set_name: RedPajamaCommonCrawl


classified | Inachee- Ethical Business Advisory for Uganda.
Online classifieds website/portal? Who wants to be a millionaire?
Christine S. Kadama is an IT consultant in the Washington D.C Metro Area. Her specialisms include Project Management, Process Improvement, Business Development, Content Management Systems, Web 2.0 technologies, Collaboration, Information architecture, Requirements Analysis, Technical writing, Product development, SharePoint 2003/2007, Training and Presentation.
Christine has previously worked as an IT consultant-TGSIM at the International Monetary Fund. She studied at The George Washington University- School of Business.


We've waxed on about the power of uniform dressing: Steve Jobs was a fan, as is Hillary Clinton. There is something undeniable about knowing what works for you and wearing said outfit (or variation of said outfit) with aplomb. Nobody knows this better than fashion designers, whose job it is to make everyone look their best at all times.
Naturally, women like Diane von Furstenberg, Carolina Herrera, and Victoria Beckham practice what they preach because they, too, sport some iteration of their own uniform. Von Furstenberg, for her part, prefers a printed tunic dress, which she calls a "petite valise," while Beckham loves herself some menswear-inspired suiting. Ahead, eight fashion designers in their signature uniforms.
Herrera is rarely seen without her white shirt. "Fashion is supposed to be for the everyday," she said. "I have worn the white shirt since I was very young." Herrera even manages to take her favorite design from day to night. "It doesn't always look like a white shirt even though it is," she said. "With trouser or a short skirt it can be worn for day and then later with evening jewels and a ball skirt for night."
Beckham knows the power of tailoring and is often seen in menswear-inspired pieces, like a knee-length coat and smart trousers. Ladylike pumps and oversize sunglasses usually complete the look.
As an advocate of seven easy pieces, Karan knows the importance of editing one's wardrobe. For her part, she is usually seen in an all-black uniform of a blouse, edgy pants, tough boots, and a statement necklace.
When turning up the glamour for red carpet events, Wang is often seen in long sleeveless black gowns with some sort of fabric detail, like pleats.
Johnson loves wacky, playful designs on the runway, but for her everyday uniform, she likes to incorporate black-and-white stripes in the form of dresses, leggings, and jumpsuits.
Minkoff relies on old standbys, like a leather motorcyle jacket, a printed top, jeans, and statement heels.
Rowley loves herself a statement piece in the form of feathery knee-length skirts and colorful toppers.


text:
Capturing the Campaigns
By Melissa Osorio on Sep 12, 2016
Balloons and confetti, speeches and sound-bites, pundits and polls – all signal a U.S. election season in full flight. And the surest signs of the season are buttons and bumper stickers, postcards and posters, and, inevitably, emails and phone calls. This sometimes useful, often annoying, always ephemeral documentation provides fertile fodder for research by students and scholars of communications and media, history, law, political science, and many other disciplines.
Launched in the 1920s, the UCLA Library's Campaign Literature Archive contains print election materials for federal, state, and local offices and ballot measures affecting Los Angeles. Since 1998 it captures campaign websites as well. In addition, earlier this year the Library created a web archive of the UK Brexit campaign websites – and just in time, too, as some of the parties had started to remove or alter their contents!
You can view more at digital.library.ucla.edu/campaign.
Welcome Lorenza Herrera, NNLM PSR Office Manager
Welcome Ariane Bicho, Director of Communications and Marketing
Fair Use and Images
Processing the Chinese Printed and Manuscript Medical Books in the CFPRT
Interpreting the Evidence: A Look into the Inner Workings of the Utagawa, Kuniyoshi suikoden Binding


Hello, I would like more information about the 2008 Chevrolet Silverado 1500, stock# 3282.
Please text me about this 2008 Chevrolet Silverado 1500 (3GCEK13348G296952).
Hello, I would like to see more pictures of the 2008 Chevrolet Silverado 1500, stock# 3282.


text:
Q: Return empty string in decimal function in c# I create a function to compare the price of my item.
This is my function:
public static decimal ComparePrice(decimal Price, decimal WebsitePrice)
    {
        decimal ZERO_PRICE = 0.00000M;
        if(Price == ZERO_PRICE && WebsitePrice > ZERO_PRICE){
            return WebsitePrice;
        }else if(Price == ZERO_PRICE && WebsitePrice == ZERO_PRICE){
            return "";
        }else{
            return Price;
        }

    }

if the both(price and websiteprice) is equal 0.00, then it will return the empty string, I know it is not possible to return the string while the function is set to decimal type, but i have no idea what should I do about that. Anyone can help? Thanks.

A: If it makes sense in your application logic, you can use a Nullable type and use null instead of an empty string. Like :
public static decimal? ComparePrice(decimal Price, decimal WebsitePrice)
    {
        if(Price == decimal.Zero && WebsitePrice > decimal.Zero){
            return WebsitePrice;
        }else if(Price == decimal.Zero && WebsitePrice == decimal.Zero){
            return null;
        }else{
            return Price;
        }

    }

Or use Decimal.MinValue as suggested as a flag for invalid. (I like the null better, again, just if this is actually a valid value in your logic).

A: Why dont you return simple 0.0
Of course when both values are 0.0 .. returning 0.0 make sense.

A: C# has had nullable types for quite a while now, try defining your method like this and returning null for the case in question:
public static decimal? ComparePrice(decimal Price, decimal WebsitePrice)

A: You could always return something like decimal.MinValue that would indicate they were both a zero price item.

redpajama_set_name: RedPajamaStackExchange


" Do you want it ? It's for you ! "
Nala & Nanouk working test Pomarède 1999.
Our young ESS also !
One day successful for our working group, relaxation for all !
at 9 years old, always also passionate !
...waiting the orders from the judge.
Timothée, " champion of dives '08 "
With proud & hapiness !


Led by amazing instructors, our group fitness classes offer community, energy and motivation to create a transformative experience and deliver fitness results. Enjoy your favorite workouts, from cardio and dance (like Zumba!) to strength-training, conditioning and yoga, all conveniently located at your local club and expertly designed to keep you moving toward your best self. Best of all, classes are included in your membership!


text:
UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
Delores J. Grant1,
Zinan Chen2,
Lauren E. Howard2,
Emily Wiggins3,
Amanda De Hoedt3,
Adriana C. Vidal4,
Skyla T. Carney1,
Jill Squires5,
Clara E. Magyar5,
Jiaoti Huang5 &
Stephen J. Freedland4
Uridine 5′-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate tissue samples from hormone therapy-naïve patients.
We determined the expression of UGT2B15, UGT2B17, and UGT2B28 enzymes in 190 prostate tissue samples from surgical specimens of a multiethnic cohort of patients undergoing radical prostatectomy at the Durham Veterans Affairs Medical Center. The association between each protein's percent positive and H-score, a weighted score of staining intensity, and the risk of biochemical recurrence (BCR) was tested using separate Cox proportional hazards models. In an exploratory analysis, UGT2B17 total positive and H-score were divided at the median and we tested the association between UGT2B17 group and risk of BCR.
The median follow-up for all patients was 118 months (IQR: 85-144). Of 190, 83 (44%) patients developed BCR. We found no association between UGT2B15 or UGT2B28 and risk of BCR. However, there was a trend for an association between UGT2B17 and BCR (HR = 1.01, 95% CI 1.00-1.02, p = 0.11), though not statistically significant. Upon further investigation, we found that patients with UGT2B17 higher levels of expression had a significant increased risk of BCR on univariable analysis (HR = 1.57, 95% CI 1.02-2.43, p = 0.041), although this association was attenuated in the multivariable model (HR = 1.50, 95% CI 0.94-2.40, p = 0.088).
Our findings suggest that UGT2B17 overexpression may be associated with a significant increased risk of BCR. These results are consistent with previous reports which showed UGT2B17 significantly expressed in advanced prostate cancer including prostate tumor metastases.
It is estimated that there will be approximately 161,360 new cases of prostate cancer (PC) and approximately 26,730 deaths from PC in the US population in 2017 [1]. While overall the average annual percent change in PC incidence and death from 2009 to 2013 has decreased by 8.6%, the death rates in black men was 2.3 times those in white men. Critical to the treatment and prognosis of prostate cancer is the identification of biomarkers by tumor clinicopathologic characteristics to direct the development of therapies and treatment options. Biomarkers that are involved in adrenal and instraprostatic androgen biosynthesis and metabolism have emerged as important targets [2]. Common androgen deprivation therapy (ADT) agents used in individuals with metastatic prostate cancer point to the relevance of androgens/androgen receptor signaling in tumor progression in the prostate cancer cell microenvironment [3]. Various expression levels of steroideogenic enzymes, involved in the biosynthesis of testosterone precursors, have been differentially associated with prostate tumor progression to castration-resistant prostate cancer (CRPC) [2, 4,5,6]. Moreover, recent evidence suggests that steroideogenic enzymes responsible for the catabolism of intraprostatic testosterone metabolites may be linked to biochemical recurrence (BCR) and tumor progression to CRPC, however, those associations are less understood [2, 7,8,9,10,11,12].
Uridine 5′-diphosphate-glucuronosyltransferases (UGT) are part of a superfamily of enzymes which are part of the phase II drug detoxification pathways in the hepatic tissue in mammals. The UGTs catalyze the addition of the hydrophilic moiety, glucuronide to acceptor molecules in a process called glucuronidation [13, 14]. In humans there are two major classes, UGT1 and UGT2, which each contain multiple genes on chromosome 2 and 4, respectively. The UGT2B subfamily is comprised of UGT2B4, UGT2B7, UGT2B11, UGT2B15, UGT2B17, and UGT2B28 along with six pseudogenes that are interspersed among the genes in the region [15]. Enzymes UGT2B15 and UGT2B17 exhibit substrate specificity for androgens such as testosterone, dihydrotestosterone (DHT), DHT metabolites, androsterone and 5α-androstane-3α,17β-diol [16, 17]. Furthermore, those enzymes conjugate androgens present in the lumen and basal epithelial tissue of the prostate [18, 19]. The UGT2B28 enzymes have been shown to be expressed in human testis, prostate, and prostate cancer cell line, LNCaP, where they conjugate 5α-androstane-3α,17β-diol, 5β-androstane-3α,17β-diol and androsterone, and testosterone [20] (Fig. 1). The conjugation of androgens and their metabolites by the UGT2B enzymes in prostate tissue is an irreversible reaction, effectively regulating the levels of DHT available for androgen receptor signaling [19, 21]. Thus the expression levels of UGT2B17, B15, and B28 may be predictors of intraprostatic levels of androgens and prostate cancer phenotype.
Glucuronidation targets for UGT2B15, UGT2B17, and UGT2B28 enzymes in the prostate [3, 19, 23]. Thick black arrows indicate irreversible production of testosterone- and DHT-G. Curved arrow indicates irreversible production of ADT-G; and parallel wide arrow indicates irreversible production of AAG. DHEA, dehydroepiandersterone; Testo, testosterone; DHT, dihydrotestosterone; ADT-G, androsterone glucuronide
A couple of studies have suggested that expression levels of the UGT2B17, B15, and 28 enzymes may be prognostic for clinicopathologic characteristics of prostate cancer. In one study the expression levels of UGT2B17 and B15 in prostate tumor samples from ADTh treated patients were compared to expression levels in patients that were untreated or diagnosed as benign prostatic hyperplasia (BPH) [22]. The results showed that UGT2B15 expression in patients that were treated up to 12 months with ADTh was significantly higher when compared to expression levels in patients that received no treatment for a comparable time or were diagnosed with BPH. Results from the same study showed that UGT2B17 expression was significantly elevated for only 5 months in ADTh treated patients. In another study examining the association of UGT2B28 expression, Belledant et al. [21] demonstrated that higher cytoplasmic expression of the protein was significantly associated with higher Gleason scores and positive nodes. In contrast, lower nuclear expression was associated with decreased PSA and positive margins. These studies suggest that UGT2B expression was altered by intraprostatic levels of androgens and tumor aggression.
To assess whether expression levels of UGT2B enzymes would predict worse prostate cancer outcomes, we analyzed the association between expression of UGT2B15, B17 and B28 in tumor microarrays at the time of radical prostatectomy and risk of BCR. We hypothesized that higher expression of the UGT2B enzymes is associated with increased prostate cancer progression risk.
A retrospective study was conducted on 196 patients undergoing radical prostatectomy at the Durham Veterans Affairs Medical Center (DVAMC) between 1993 and 2004. None of the patients had hormonal ablation or radiation therapy prior to surgery. Four core needle biopsies of cancer of the formalin fixed and paraffin embedded radical prostatectomy specimens were used to create tissue microarrays (TMAs). Slices of the TMA were stained for expression of UGT2B15, UGT2B17, and UGT2B28. We used two indicators for the staining power of the biomarkers, the average percentage of positive staining cells, and H-score. H-score was calculated for each of the three biomarkers using the formula: 3*percent staining strong +2*percent staining medium +1*percent staining weak staining.
Patients were followed for a median of 118 months. Biochemical recurrence (BCR) was defined as a single PSA value of >0.2 ng/ml, two values of 0.2 ng/ml, or need for secondary treatment for elevated PSA in the post-operative period. We excluded 1 patient missing extra-capsular extension, 2 missing seminal vesicle, and 3 missing follow-up, leaving a total of 190 patients in our study cohort. Institutional Review Board approval was obtained at Duke University, North Carolina Central University and the DVAMC and all patients signed an informed consent at the DVAMC prior to enrollment.
Immunohistochemistry of tissue microarrays
For all antibodies, TMA slides from DVAMC were baked overnight in a 60 °C oven before IHC staining. The staining protocols are as follows: UGT2B15: Sections were deparaffinized with xylene and rehydrated through graded ethanol. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide in methanol for 10 min. Heat-induced epitope retrieval (HIER) was carried out in EDTA, pH 8.0 (Invitrogen, cat# 005501) using a vegetable steamer at 95 °C for 25 min. Mouse polyclonal anti-human UGT2B15 primary antibody (Abcam, ab89274) was diluted with BSA to a concentration of 1:50 and applied to the sections overnight at 4 °C. Slides were rinsed with PBS then Dakocytomation Envision System Labelled Polymer HRP anti-mouse (DakoCytomation, cat# K4001) secondary antibody was applied for 30 min at room temperature. The antibody was then visualized using the Betazoid DAB Chromogen Kit (BioCare Medical, cat# BDB2004L). Finally, sections were rinsed with water, counterstained with hematoxylin, dehydrated through graded ethanol, cleared with xylene, and coverslipped.
UGT2B17: Sections were deparaffinized with xylene and rehydrated through graded ethanol. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide in methanol for 10 min. Heat-induced epitope retrieval (HIER) was carried out in EDTA, pH 8.0 (Invitrogen, cat# 005501) using a vegetable steamer at 95 °C for 25 min. Rabbit polyclonal anti-human UGT2B17 primary antibody (Abcam, ab92610) was diluted with BSA to a concentration of 1:50 and applied to the sections overnight at 4 °C. Slides were rinsed with PBS then Dakocytomation Envision System Labelled Polymer HRP anti-rabbit (DakoCytomation, cat# 4003) secondary antibody was applied for 30 min at room temperature. The antibody was then visualized using the Betazoid DAB Chromogen Kit (BioCare Medical, cat# BDB2004L). DAB was rinsed away with distilled water, cupric sulfate was applied for 5 min, and the tissue was rinsed again with distilled water. Finally, sections were rinsed with water, counterstained with hematoxylin, dehydrated through graded ethanol, cleared with xylene, and coverslipped.
UGT2B28: Sections were deparaffinized with xylene and rehydrated through graded ethanol. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide in methanol for 10 min. Heat-induced epitope retrieval (HIER) was carried out in 0.01 M citrate buffer, pH 6.0 using a vegetable steamer at 95 °C for 25 min. Rabbit polycloncal anti-human UGT2B28 primary antibody (Abcam, ab156131) was diluted with BSA to a concentration of 1:50 and applied to the sections for 45 min at room temperature. Slides were rinsed with PBS then Dakocytomation Envision System Labelled Polymer HRP anti-rabbit (DakoCytomation, cat# 4003) secondary antibody was applied for 30 min at room temperature. The antibody was then visualized using the Betazoid DAB Chromogen Kit (BioCare Medical, cat# BDB2004L). Finally, sections were rinsed with water, counterstained with hematoxylin, dehydrated through graded ethanol, cleared with xylene, and coverslipped.
Slides were digitized on a ScanScope AT (Leica Biosystems, Inc., Vista, CA) and morphimetric analysis performed with Definiens' Tissue Studio (Definiens Inc., Parsippany, NJ) to determine the percentage of UGT2B15, UGTB17, UGTB28 and EGFR positive cells in a non-biased method. Briefly, stain specific algorithims were created using the pre-defined cytoplasmic detection module and classification tool, positive and negative stained cells within each tissue region were identified. Thresholds were set to classify hematoxylin stain for nuclei and DAB stain for positive cytoplasmic staining. The data were exported to Excel for further statistical analysis. Scanning and analyses were performed through the Translational Pathology Core Laboratory, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA.
Patient characteristics were summarized using median, 25th percentile, and 75th percentile for continuous variables and count and percentage for categorical variables. We tested the association between each biomarker's (UGT2B15, UGT2B17, UGT2B28 – all continuous) percent positive and H-score and the risk of BCR using separate Cox proportional hazards models. Both crude models and models adjusted for PSA (continuous, log-transformed), age (continuous), pathological Gleason score (2-6 vs. 3 + 4 vs. ≥4 + 3), race (black vs. non-black), positive surgical margins (yes vs. no), extracapsular extension (yes vs. no), and seminal vesicle invasion (yes vs. no) were fit. In these models, UGT2B15, UGT2B17, and UGT2B28 percent positive and H-score were modeled per 10-unit increase. In an exploratory analysis, we split UGT2B17 total positive and H-score at the median and tested the association between UGT2B17 group and risk of BCR.
We also tested whether UGT2B15, UGT2B17, or UGT2B28 H-scores were correlated with pathological Gleason score using the Kruskal-Wallis test or chi-square test. For each level of Gleason score (2-6 vs. 3 + 4 vs. ≥4 + 3), we reported median, 25th percentile, 75th percentile of the biomarker H-score, <median (low expression), and ≥median scores (high expression).
The demographic characteristics of the study population and their clinical and pathologic phenotypes are summarized in Table 1. The median age of the cohort was 63 years (Q1-Q3: 58-67) and less than half (48%) of the patients were black. The median follow-up time was 118 months (Q1-Q3: 85-144 months). Expression of the UGT2B isoforms was assessed by immunohistochemical detection (Fig. 2). The median percentage of cells staining positive for UGT2B15, UGT2B17, and UGT2B28 was 39%, 74%, and 77% respectively. The median of H-score for UGT2B15 was 40, 76 for UGT2B17, and 86 for UGT2B28.
Table 1 Demographic, clinical, and pathological characteristics of patients
Immunohistochemical detection and specificity of UDP-glucuronosyltransferase 2B (UGT2B) enzymes (brown stain) at 10X magnification. a Normal kidney tissue showing negative UGT2B staining. b Tonsil tissue showing positive UGT2B staining throughout basal layer. c Prostate cancer with positive UGT2B staining
There was no association between UGT2B15 or UGT2B28 percent positive or H-score on univariable or multivariable analysis (all HR = 0.98-1.08, p > 0.5; Table 2) when biomarkers were modeled per 10-unit increase. Similarly, there was no association between UGT2B17 H-score on univariable or multivariable analysis (HR 1.05, p > 0.2; 1.03, p > 0.4). However, there was a trend between higher UGT2B17 percent positive and increased risk of BCR (HR 1.11, 95% CI 0.98-1.25, p = 0.09) on univariable analysis, although this did not reach statistical significance. This trend was weakened on multivariable analysis (HR 1.10, 95% CI 0.98-1.25, p = 0.11).
Table 2 Hazard ratios for risk of biochemical recurrence by UGT2B15, UGT2B17, UGT2B28 measures
Notably in secondary analysis, patients with UGT2B17 total positive above the median had a significant increased risk of BCR on univariable analysis (HR = 1.57, 95% CI 1.02-2.43, p = 0.041; Table 3). However, this association was attenuated in the adjusted model (HR = 1.50, 95% CI 0.94-2.40, p = 0.088). There was no association between UGT2B17 H-score groups and BCR on univariable (p = 0.20) or multivariable (p = 0.32) analyses. Upon further inspection, pathological Gleason score and seminal vesicle invasion were the greatest mediators between UGT2B17 and BCR. Specifically, after adjusting for these two variables, the HR is 1.28 (95% CI 0.81-2.00; p = 0.29).
Table 3 Hazard ratios for risk of biochemical recurrence by UGT2B17 total percent positive and H-score 2 groups
Finally, we found no association between H-scores of UGT2B15, UGT2B17, or UGT2B28 and pathological Gleason score (p = 0.34, 0.92, 0.80, respectively; Table 4). There were no interactions between the biomarkers and race (p = 0.65 for UGT2B15, p = 0.10 for UGT2B17, p = 0.27 for UGT2B28).
Table 4 Association between UGT2B15, UGT2B17, UGT2B28 H-scores and pathological Gleason score
There is increasing evidence that standard approaches to ADT that involve targeting enzymes involved in androgen biosynthesis and orchiectomy are not sufficient to prevent the development of CRPC [2]. The goal of these therapies is to diminish the availability of DHT activated androgen receptor (AR) to promote cancer cell proliferation and growth through AR specific gene activation [6]. The UGT2B enzymes, UGT2B15, B17, and B28, which are regulated in part by the AR, are responsible for the removal of DHT metabolites in an irreversible glucuronidation reaction [19, 23]. In vitro experimental evidence has shown that the amounts of DHT are lower in culture media in control prostate cancer cell lines not treated with UGT2B17/B15 si-treated cell. Thus the enzymes may play a critical role in hormone levels in prostate cancer influencing tumor aggression and promotion. We sought to evaluate the expression of three UGT2B enzymes for their association with clinical and pathological characteristics of a multiethnic population from the Durham Veterans Affairs Medical Center, and evaluate whether their expression levels would predict prostate cancer outcomes after radical prostatectomy. Our results show that UGT2B17 overexpression was associated with a significant increased risk of BCR and that association was attenuated in adjusted models. That association was not modified by race. However, there were no significant associations between UGT2B17 expression and pathological Gleason score. The expression of UGT2B15 and B17 enzymes was not associated with any clinical and/or pathological characteristics.
To date no study has compared the expression of UGT2B17 and UGT2B17 to clinicopathologic characteristics of prostate tissue. Results from Grosse et al., [22] showed that expression of the UGT2B enzymes in samples from ADT treated patients were significantly higher than those of untreated patients. However UGT2B17 and B15 expression in the ADT untreated samples was not evaluated for association with clinical and pathological characteristics of prostate cancer such as BCR, PSA, pathological Gleason score, positive surgical margins, extracapsular extension and seminal vesicle invasion. The tissue used in this study was from patients who had no hormonal ablation or radiation therapy prior to prostatectomy surgery, therefore any comparison to the previous study may not be accurate. The results from our study showed no significant associations with BCR and Gleason score for UGT2B28 expression. In contrast, previous report showed that UGT2B28 overexpression was associated with lower PSA, high Gleason score, and BCR [21]. In that study, antibody staining was targeted in the basal cells of the prostate tumor and were cytoplasmic or nuclear. Further patient tissue samples with strong nuclear staining were associated with low PSA and positive margins while strong cytoplasmic staining was associated with positive nodal status and higher Gleason score. Interestingly in that same study, prostate secretory cells showed low to moderate staining. The results in our study emanated from cytoplasmic stained patient tissue samples that were not enriched for specifically for prostate basal cells. The population make-up in the studies may be different since the above study included patients from hospitals in Quebec, Canada and our study included Black and non-black patients in equal proportions. It is not clear if individuals of African descent have been characterized for UGT2B28 expression or polymorphisms. These differences in staining approaches and sample population may account for the differences in results.
Genetic studies have demonstrated a relationship between UGT2B genes and clinical and pathologic characteristics of prostate cancer. For example, a study has shown that deletions of UGT2B17 and B28 genes were significantly associated with decreased survival in Caucasians and Asians while deletion of only UGT2B17 was associated with Gleason score in Asians [24]. While significantly lower steroid glucuronides were found in that study, no other association was shown with PSA, Gleason score and tumor node metastasis. The expression levels of the UGT2B genes were not observed. Previous studies have shown that low expression levels of UGT2B17/15 in the LNCaP prostate cancer cell line resulted in lower intracellular glucuronide levels [19, 23]. In the current study, the results suggest that UGT2B17 overexpression was associated with BCR, which may be an indication overexpression may be a marker for tumor progression to CRPC independent of intracellular glucuronide levels. Another UGT gene has recently been implicated as a probable prognostic marker. Single nucleotide polymorphisms of the UGT1A locus (UGT1A9, UGT1A10) have been significantly associated with decreased survival following BCR [25]. In that same study, some SNPs from the same genes were protective and conferred decreased risk of BCR. Interestingly, the UGT1A risk alleles did not significantly change androgen glucuronide levels. UGT1A class expression was shown to be decreased in prostate cancer stem cells and in metastatic CRPC cells while in vitro experiments with LNCaP prostate cancer cell lines suggests this decreased expression is associated with cell survival [26]. This may be an indication that the expression of UGT2B genes in the prostate are critical to the hormonal microenvironment.
Our study has some limitations. The small sample size may have limited the power to detect significant associations between UGT2B17 expression and BCR on multivariable analysis. In addition we had a few number of events for CRPC and metastases, thus we could not evaluate the associations between UGT2B expression levels and those long-term prostate cancer outcomes. UGT2B17 expression has been found to be significantly expressed in prostate cancer metastases and CRPC tumors, while UGT2B15 is negatively regulated in those tissues [26]. Elevated circulating testosterone has been associated with UGT2B28 nuclear staining which may decrease expression of UGT2B15 and UGT2B17 since studies show that their expression is elevated in patients and prostate cancer cell cultures treated with antiandrogens [21, 22]. This suggests that other factors may be acting in tissues with deleted UGT2B17 and have higher biochemical recurrence.
In conclusion, the results from this study are suggestive that UGT2B17 overexpression may be associated with an increased risk of BCR. This study contributes to an emerging field of investigation that seeks to uncover the novel predictors of intraprostatic levels of androgens that persist in CRPC and the subsequent development of prostate tumor metastases [27]. Future analyses with increased sample sizes and data on UGT2B gene variants are needed, as those variants continue to show impact on the risk for prostate cancer [28]. The UGT2B enzymes, UGT2B15, B17, and B28 are responsible for much of the catabolism of testosterone and DHT metabolites in the prostate and must be further investigated to assess their importance as putative biomarkers and therapeutic targets.
ADT:
BCR:
biochemical recurrence
DHT:
dihydrotestosterone
hazards ratio
UGT:
UDP-glucuronosyltransferase
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30.
Mitsiades N. A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer. Cancer Res. 2013;73(15):4599–605.
Hara N, Nishiyama T. Androgen metabolic pathway involved in current and emerging treatment for men with castration resistant prostate cancer: intraprostatic androgens as therapeutic targets and endocrinological biomarkers. Curr Drug Targets. 2014;15(13):1215–24.
Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, Fleisher M, Sander C, Sawyers CL, Scher HI. Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Res. 2012;72(23):6142–52.
Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W, et al. Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. J Steroid Biochem Mol Biol. 2013;138:281–9.
Bambury RM, Rathkopf DE. Novel and next-generation androgen receptor-directed therapies for prostate cancer: beyond abiraterone and enzalutamide. Urol Oncol. 2015;34(8):348–55.
Santer FR, Erb HH, McNeill RV. Therapy escape mechanisms in the malignant prostate. Semin Cancer Biol. 2015;35:133–44.
Mitra R, Goodman OB Jr. CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR. Prostate. 2015;75(5):527–38.
Levesque E, Laverdiere I, Lacombe L, Caron P, Rouleau M, Turcotte V, Tetu B, Fradet Y, Guillemette C. Importance of 5alpha-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer. Clin Cancer Res. 2014;20(3):576–84.
Crawford ED. Understanding the epidemiology, natural history, and key pathways involved in prostate cancer. Urology. 2009;73(5 Suppl):S4–10.
Titus MA, Li Y, Kozyreva OG, Maher V, Godoy A, Smith GJ, Mohler JL. 5alpha-reductase type 3 enzyme in benign and malignant prostate. Prostate. 2014;74(3):235–49.
Taplin ME, Manola J, Oh WK, Kantoff PW, Bubley GJ, Smith M, Barb D, Mantzoros C, Gelmann EP, Balk SP. A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones. BJU Int. 2008;101(9):1084–9.
Rowland A, Miners JO, Mackenzie PI. The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. Int J Biochem Cell Biol. 2013;45(6):1121–32.
Dutton GJ. Developmental aspects of drug conjugation, with special reference to glucuronidation. Annu Rev Pharmacol Toxicol. 1978;18:17–35.
Guillemette C, Levesque E, Harvey M, Bellemare J, Menard V. UGT genomic diversity: beyond gene duplication. Drug Metab Rev. 2010;42(1):24–44.
Turgeon D, Carrier JS, Levesque E, Beatty BG, Belanger A, Hum DW. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. J Mol Biol. 2000;295(3):489–504.
Turgeon D, Carrier JS, Levesque E, Hum DW, Belanger A. Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology. 2001;142(2):778–87.
Chouinard S, Pelletier G, Belanger A, Barbier O. Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. Endocr Res. 2004;30(4):717–25.
Chouinard S, Yueh MF, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, Belanger A. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008;109(3-5):247–53.
Levesque E, Turgeon D, Carrier JS, Montminy V, Beaulieu M, Belanger A. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry. 2001;40(13):3869–81.
Belledant A, Hovington H, Garcia L, Caron P, Brisson H, Villeneuve L, Simonyan D, Tetu B, Fradet Y, Lacombe L, et al. The UGT2B28 sex-steroid inactivation pathway is a regulator of Steroidogenesis and modifies the risk of prostate cancer progression. Eur Urol. 2015;69(4):601–9.
Grosse L, Paquet S, Caron P, Fazli L, Rennie PS, Belanger A, Barbier O. Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications. Cancer Res. 2013;73(23):6963–71.
Chouinard S, Barbier O, Belanger A. UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. J Biol Chem. 2007;282(46):33466–74.
Nadeau G, Bellemare J, Audet-Walsh E, Flageole C, Huang SP, Bao BY, Douville P, Caron P, Fradet Y, Lacombe L, et al. Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer. J Clin Endocrinol Metab. 2011;96(9):E1550–7.
Laverdiere I, Flageole C, Audet-Walsh E, Caron P, Fradet Y, Lacombe L, Levesque E, Guillemette C. The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy. Endocr Relat Cancer. 2015;22(1):77–85.
Williamson SC, Mitter R, Hepburn AC, Wilson L, Mantilla A, Leung HY, Robson CN, Heer R. Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer. Br J Cancer. 2013;109(4):950–6.
Zhang A, Zhang J, Plymate S, Mostaghel EA. Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression. Horm Cancer. 2016;7(2):104–13.
Hu DG, Mackenzie PI, McKinnon RA, Meech R. Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk. Drug Metab Rev. 2016;48(1):47–69.
We thank Dr. Cathrine Hoyo for valuable data critique and Ms. Jasmine Parker for assistance in the preparation of the EndNote library. The reagents, supplies and personnel were supported by funding from the Department of Defense PC60233, NIH grants NIH P20 MD000175, S06-GM008049-33, 1R21ES021838-01A1, NIH CA160653, Duke University, Durham Veterans Affairs Medical Center, Cedars-Sinai Health System and the Department of Pathology and Laboratory Medicine and the David Geffen School of Medicine at UCLA.
Department of Defense PC60233, NIH P20 MD000175, S06-GM008049-33, 1R21ES021838-01A1 to DJG and NIH CA160653 to SJF.
The IRB protocol at the Durham Veterans Affairs Medical Center does not allow data sharing of this sort.
Department of Biological and Biomedical Science, Cancer Research Program, North Carolina Central University, Julius L. Chambers Biomedical/Biotechnology Research Institute, 1801 Fayetteville Street, Durham, NC, 27707, USA
Delores J. Grant & Skyla T. Carney
Department of Biostatistics and Bioinformatics, Duke University Medical Center, 2424 Erwin Road, Suite 1102 Hock Plaza, Box 2721, Durham, NC, 27710, USA
Zinan Chen & Lauren E. Howard
Durham Veterans Administration Medical Center, 508 Fulton St, Durham, NC, 27705, USA
Emily Wiggins & Amanda De Hoedt
Cedars-Sinai Health System, Center for Integrated Research on Cancer and Lifestyle, Cancer Genetics and Prevention Program, Surgery, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA
Adriana C. Vidal & Stephen J. Freedland
Department of Pathology and Laboratory Medicine, University of California at Los Angeles, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, CHS 14-112, Los Angeles, CA, 90095, USA
Jill Squires, Clara E. Magyar & Jiaoti Huang
Delores J. Grant
Zinan Chen
Lauren E. Howard
Emily Wiggins
Amanda De Hoedt
Adriana C. Vidal
Skyla T. Carney
Jill Squires
Clara E. Magyar
Jiaoti Huang
Stephen J. Freedland
DJG conceived and designed the experiments. EW, ADH and SJF provided the samples. STC, JS, CEM, and JH optimized reagents and generated data. ZH and LEH performed statistical analysis on data. DJG, ACV, LEH wrote and edited manuscript. All authors have read and approved the final manuscript.
Correspondence to Delores J. Grant.
Institutional Review Board approval was obtained at Duke University and the Durham Veterans Affairs Medical Center.
Institutional Review Board approval was obtained North Carolina Central University (waived).
Grant, D.J., Chen, Z., Howard, L.E. et al. UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression. BMC Cancer 17, 463 (2017). https://doi.org/10.1186/s12885-017-3463-6
UDP-glucuronosyltransferases
UGT2B17
Epidemiology, prevention and public health


text:
Alexis Brice
General director of the ICM
Email - Alexis
Alexis Brice is general director of the ICM; he is coordinator of team molecular basis, pathophysiology and treatment of neurodegenerative diseases and of the DNA and cell bank. Alexis is also professor of medical genetics at Pierre and Marie Curie University, and hospital practitioner in neurology. He received a M.D. in 1988 and a board certification in Neurology in 1991. He was elected member at National Academy of Medicine in 2007, for the biology section, he received in 2011 the "Prix Lamonica" of Academy of Science in Neurology for this research on Parkinson's disease and in 2012 the ROGER DE SPOELBERCH Prize for research in neurodegenerative diseases.
He has held positions in a variety of national and international scientific organizations, and is a member of the editorial board of several journals in the fields of Genetics and Neurology.
He was the first Chairman of the Institute for Neuroscience, Cognitive Sciences, Neurology and Psychiatry at Aviesan.
His research, which includes both clinical and basic research, aims at elucidating the molecular basis and physiopathological mechanisms of several hereditary neurodegenerative disorders including Parkinson's disease, frontotemporal lobar degeneration and spinocerebellar degenerations. He has published over 470 research papers with over 24000 citations.
Groupe Hospitalier Pitié Salpêtrière, ICM - Institut du Cerveau et de la Moelle Epinière
47, Boulevard de l'Hôpital
Paris Cedex 13
www.icm-institute.org


text:
package week.five;

public class Ulica {
	protected char[] nazov = new char[20];
	protected final int pocetPozemkov = 100;
	protected int pocetPruhov;
}

redpajama_set_name: RedPajamaGithub


text: The Kunsthalle in Budapest is marking the 120th anniversary of its opening with a special exhibition. It showcases the masterpieces of the period when the exhibition hall was inaugurated, the era of prosperity in the Dual Monarchy. A key concept in selecting the displayed works was that a significant number of their artists were in the past represented in the institute. The importance of the monarch is reflected in the material and structure. After all, the theme pinpoints "painting in the era of Franz Joseph" and this primarily involves the period from the time when he was crowned king to the end of his reign. The organising institution of artistic life at the time was the National Hungarian Fine Arts Society, established in 1861. The connoisseur and art collector Andrássy Gyula was its president until 1866. He was followed by Ferenc Pulszky, the director of the National Museum. The history of the Society and the Kunsthalle reflects an era's art history, more precisely the presentation of one layer and interpretation of the arts in the era – the paintings, the exhibition texts as well as the studies in the catalogue represent this. Art sponsorship by cultural policy, which was manifested from the time of the establishment of the National Hungarian Fine Arts Society, was based on the recognition attributed to József Eötvös, according to which art was a power for the state to utilise. Analysing Eötvös's art policy, Béla Lázár recalled how, in 1914 when visiting the Alte Pinakothek in Munich, Eötvös realized that the arts had a feature "reinforcing the state". This primarily meant that the state had to educate artists and the masses. The Kunsthalle, "the consecrated temple of the arts", was built for the 1896 Millenary celebrations. A large exhibition encompassing the history of Hungarian painting opened presenting 1276 works by 267 Hungarian artists. Critics had their reservations. According to its curator, the exhibition was characterised by "high quality and a rich pluralism of styles". Undoubtedly, visitors saw a varied compilation of artworks – and why could have anyone expected to see anything other than the selected works? What is the aim of this exhibition? To remember the history of an institution by presenting an era, celebrating an anniversary? "The era of Franz Joseph's reign was a real golden age for the arts, including painting. Such works were created in the national schools of painting, which are outstanding in the era's European art, even by international standards. The age was the star clock of Central European painting, which must be rediscovered from time to time," writes the curator. Yes, the above characterised the era and its painting, as did many other things, too. For the Kunsthalle with its exhibition it was understandably to be presented. If an institution wants to pay respects to its own past, it cannot deny itself.


With her zen-like, low key manner Ani Antreasyan isn't your typical decorator. But her sensibility for juxtaposing the rough hewn and repurposed with the modern; mixing historical objects together, and her love affair with ancient stone, wood and metal have made her one of the vanguard tastemakers redefining Hamptons style. It's all about bringing the beauty of outdoors in, she likes to say.
Like her style, Ani's career has progressed organically. She got the first job she ever interviewed for: at the Metropolitan Museum's retailing department, where she ultimately moved to the design department installing exhibitions. After ten years, and a graduate degree in design at SVA, Ani opened her own business importing antique marble sinks from her native Turkey. The first time she brought them to the Bridgehampton Antiques show, under the name Canyan Antiques in 1998, a Water Mill woman bought eight and hired Ani as her decorator. That home made the cover of House Beautiful. Ani's next home made the cover of Garden Design Magazine. "Then, Elle Decor published my apartment in the city and HC&G published my cottage in East Hampton. So, it just kept rolling," Ani told us. "People see my work and they call me."
Christie Brinkley, Tony Bennett, Mariska Hargitay, Gabby Karan, Bryce Marden and Helen Marden have all collected the one of a kind objets d'art she brings back from flea markets in Paris and the South of France, her sources in Belgium, Italy, England, Turkey, "everywhere except Asia." She has warehouses in Manhattan and the Hamptons open to the public by appointment.
Her ancient stones lead to designing Manhattan gardens for such clients as Faith Popcorn and Jeffrey Kalinsky, of Jeffrey's department store. Other Manhattan clients brought her East to do their Hamptons homes.
Since they seek her out they share her sensibility. And, once they work with her, they wouldn't think of using anyone else for their gardens, their other homes, their flowers, or their parties.
"I do it all, really," she says. "I don't have a 'stamp'. I'm not here to change them. I want my clients to walk in and feel like it's really their home, that they have been able to be a part of the decor and the design. So, I pick a lot from what they have and fill in the rest with the same psyche. The client should be able to buy objects they get excited about to bring into the mix."
The designers Hamptons color scheme is shades of grey, white, cream, and silver blue, which she mixes herself. "It's all about bringing the outside in," Antreasyan explains. "Go to the beach and pick up two handfuls of pebbles. You can see an entire palette."
Ani continues to forge ahead, managing to be just enough ahead of the curve to make her homes 'of the moment' and exude impeccable taste. "My clients have taught me to like colors," she says. "I'm starting to work with Indian wedding hues like beautiful dark pinks and reds, the blues of the ocean. And I love throwing in an orange or purple accent."
Fifteen years before Restoration Hardware came out with their line of wrought iron lamps Ani was repurposing metal garden rails. "I had no idea it was becoming a trend," she told us. "But, I realized a few days ago when a van went by that said 'Modern Barn,' that was what I have been doing all along: putting a modern twist on ancient things."
I always knew Ani was super talented! Great to find you're excelling as always, Ani!
Ani manages to break the rule of predictability but infuses it all with serenity. Who elze can do that?


Portuguese member company, CUF, the chemical business part of the José de Mello Group, has recently rebranded to become Bondalti.
The new Bondalti brand is part of a repositioning of the company, which is currently growing and is investing in innovation across a wider range of countries. This includes a new manufacturing unit in the Spanish region of Cantabria.
Bondalti itself comes from words of Iberian origin linking "Bond", ("connection" in English), and "Alti", a Latin-derived word referring to elevation and ambition.
More information is available via the website.


UK experts say they may have found a way to check for Alzheimer's years before symptoms appear.
A lumbar puncture test combined with a brain scan can identify patients with early tell-tale signs of dementia, they believe.
Ultimately, doctors could use this to select patients to try out drugs that may slow or halt the disease.
Currently there is no single test or cure for dementia, a condition that affects over 800,000 people in the UK.
Experts are working hard to find treatments that prevent the disease or at least slow its progression.
Although there are many candidate drugs and vaccines in the pipeline, it is hard for doctors to test how well these work because dementia is usually diagnosed only once the disease is more advanced.
Dr Jonathan Schott and colleagues at the Institute of Neurology, University College of London, believe they can now detect the most common form of dementia - Alzheimer's disease - at its earliest stage, many years before symptoms appear.
Their approach checks for two things - shrinkage of the brain and lower than normal levels of a protein, called amyloid, in the cerebrospinal fluid (CSF) that bathes the brain and spinal cord.
Experts already know that in Alzheimer's there is loss of brain volume and an unusual build up of amyloid in the brain, meaning less amyloid in the CSF.
Dr Schott's team reasoned that looking for these changes might offer a way of detecting the condition long before than is currently possible.
To confirm this, they recruited 105 healthy volunteers to undergo a series of checks.
The volunteers had lumbar puncture tests to check their CSF for levels of amyloid and MRI brain scans to calculate brain shrinkage.
The results, published in Annals of Neurology, revealed that the brains of those normal individuals with low CSF levels of amyloid (38% of the group), shrank twice as quickly as the other group.
They were also five times more likely to possess the APOE4 risk gene and had higher levels of another culprit Alzheimer's protein, tau.
Although it is too soon to know if any of the volunteers will go on to develop Alzheimer's, the researchers believe their suspicions will be confirmed in the future.
Crucially, it would allow doctors to test which drugs might be beneficial in delaying or preventing dementia.
And for those who might be put off such screening by the need for a lumbar puncture, which involves drawing off fluid from around the spinal cord with a needle, experts are looking at whether a different type of brain scan might instead be used to detect amyloid.
Rebecca Wood of the Alzheimer's Research Trust, the charity that sponsored the work, said: "We are hamstrung by our inability to accurately detect Alzheimer's, but these findings could prove to be pivotal.
"We know that treatments for many diseases can be more successful if given early and this is likely to be true for Alzheimer's."
Dr Anne Corbett of the Alzheimer's Society said: "Detecting dementia early is really important. It can open doors to new treatment targets and could one day go hand in hand with an Alzheimer's vaccine that scientists are edging slowly towards.
"Testing spinal fluid is a good way of detecting Alzheimer's early but it is desperately under used in the UK.
"If we change our attitudes and invest more in research we could give hope to the million people who will develop dementia in the next 10 years. We particularly want to see this research repeated over a longer period of time to confirm the findings."
Alzheimer's disease is the most common cause of dementia, affecting around 465,000 people in the UK.
What is delaying a cure for Alzheimer's?


Is single malt whisky better than blended whisky?
I overheard an interesting conversation in an off licence the other day. A young man came in and asked the shopkeeper to help him choose a whisky for his grandfather's birthday.
"What does he like?" the shopkeeper asked.
Now, this in and of itself isn't a particularly interesting interaction; I assume it happens several times a day in most large whisky shops. What's interesting is what came later. The young man left with a bottle of blended malt whisky, having been assured by the shopkeeper that this was the best that grandpa would be getting given the price ceiling his grandson had imposed.
This prompted a lot of thoughts. Firstly, is wee Jimmy going to get a smack for daring to bring anything other than batch distilled malted barley produced at a single distillery across the threshold of dear old grandpappy's home? If he's not, and in fact grandpa only cares about the taste of what's in the glass, is this a distinction that matters to many people outside of the Scotch Whisky Association, or is it just a form of snobbery?
I'm afraid my inclination is towards the latter. Let's start by taking a look at the history of Scotch whisky. For years, Scotch whisky was blended whisky. In fact, when the industry began to boom, it was because it was blended – it finally could be blended. Frankly, back in the 19thand early 20thcentury, the single expressions of each distillery were pretty rough. Pretty rough, and incredibly variable. The early period of Scotch production can really be construed as a series of relatively wealthy, or aspirant, farmers giving distillation a crack. Monday's distillate might turn out ok, but if you took your eye off the ball on Tuesday for a minute or two - maybe there was a drainage issue in the lower field - it's possible that you just made a batch of spirit vinegar. Weirdly, few consumers wanted to take a gamble on these terms. Or at least, at the more discerning end of the market, they weren't going to come back if your last batch was a bit, erm, blinding.
This is why producers that cracked the process, and introduced some consistency, managed to create brands that were so highly regarded. They had to seek early forms of trade mark protection to distinguish themselves from poor imitations a few hundred miles away that still claimed to come from, say, Glenlivet.
Alternatively, enter the calm hand of the blender. Take John Walker, a grocer from Kilmarnock, or Messrs Chivas, shopkeepers on King Street, Aberdeen. It turns out that they had an alchemist's touch – an ability to turn the rough into the drinkable – the sort of touch that means that many generations on, they are still household names.
How did single malt become better regarded?
So how did we get from this position, to a time where Pops now believes that the only whisky worth touching is single malt? Well, legend apparently has it that the boom in single malt whisky started when a work experience kid at Glenfiddich in the early 1960s was challenged to 'get rid of' an oversupply of 12-year-old whisky. He came up with the bright idea of bottling it as a single malt and begin promoting it as 'better' or 'more genuine' than blended whisky. Fifty years on and Glenfiddich remains the biggest selling single malt in the world, and many consumers, at least in the west, still believe that single malt is somehow better, or 'more real' than blended whisky. I hope he got a full-time job out of it.
Despite this, the reality for most consumers around the world is that scotch whisky is blended whisky. Just consider the biggest selling whisky brands: Johnnie Walker, Ballantine's, Grant's, Chivas Regal. In fact, the top twenty are all blends, so Glenfiddich and The Glenlivet (the biggest selling single malts) are not even close to a seat at the top table.
Are all of these consumers wrong? Well, of course they could be, but it seems unlikely, and if they're drinking what they like, then they're doing it right as far as I'm concerned. Think of it like comparing a fine red Burgundy to a fine red Bordeaux: the Burgundy will be made with a single grape variety (Pinot Noir) and Bordeaux will be a blend (Cabernet, Merlot and some others). Neither is necessarily better nowadays. It's just a matter of style.
One thing's for sure; having tried my hand at blending whisky, it's seriously difficult, and those at the top of the game - David Stewart (William Grant & Sons), Stephanie Macleod (Dewar's) and Richard Paterson (Whyte & Mckay) - are masters of their art; highly prized and with noses insured for over £2.5m. I'm not going to tell them they're making an inferior product.


text:
O Autódromo Internacional Virgílio Távora é um autódromo localizado no município do Eusébio, na Região Metropolitana de Fortaleza. É o local onde se realizam as provas e competições de automobilismo, motociclismo e ciclismo no estado do Ceará. Seu nome é homenagem a Virgílio Távora, ex-governador, senador e ministro.

Ao longo dos anos, passou por diversas reformas. No começo de 2006, foi feita a última grande delas, com mudança de todo asfalto e melhoria da estrutura do autódromo para a realização da 2ª etapa do campeonato brasileiro de 2006 da Fórmula Truck. Atualmente, é administrado por José Haroldo Scipião Borges, presidente da Federação Cearense de Automobilismo. O autódromo também é palco de apresentações automobilísticas de manobras com carros, motos e caminhões, além de mostras e lançamentos de carros e veículos.

Histórico

O Autódromo Internacional Virgílio Távora foi o primeiro a ser construído no Nordeste. Inaugurado em 12 de janeiro de 1969 com o Grande Prêmio Ministro Mário Andreazza, prova de 65 voltas, teve como vencedor o piloto da Bahia Luís Pereira dos Santos, o "Lulu Geladeira", pilotando um Puma Espartano. Nesta prova, 16 carros largaram e a média de velocidade de "Lulu" foi de 97,5 km/h. Em 19 de outubro de 1969 aconteceu o GP do Ceará, com a participação de 22 carros e a vitória de Marivaldo Fernandes e Luis Fernando Terra Smith pilotando um Alfa GTA. Nesta época, a pista tinha um traçado simples com apenas 5 curvas e 2500 metros. A largada era no sentido horário. No ano de 1970 foi realizada a primeira prova internacional do circuito, uma etapa da Fórmula Ford com vitória de Emerson Fittipaldi. A prova de Fortaleza foi, durante muitos anos, a única prova internacional realizada no autódromo. Após este momento, as provas mais importantes realizadas foram uma etapa de Divisão 3 em 1974 e uma corrida no ano inaugural da Stockcar em 1979.

No início dos anos 1990, as provas já eram disputadas no sentido anti-horário, usando o traçado antigo. Na reforma de 1997 o traçado do autódromo foi modificado ficando mais longo. A reforma foi garantida por convênio de cooperação técnica assinado entre a Secretaria do Turismo do Estado do Ceará, a Petrobras e a Federação Cearense de Automobilismo. A reabertura aconteceu em 30 de novembro de 1997 com a realização da prova Seis Horas do Ceará. Com 237 voltas, a dupla Nelson Piquet - Ruyter Pacheco, do Distrito Federal, com um BMW, venceu a competição. Em 2000 passou por algumas reformas pequenas para sediar uma etapa da Fórmula 3. As provas sucederam-se até 2002.

Em abril de 2006 foi realizada a primeira corrida da Fórmula Truck no autódromo. As modificações feitas na reforma alargaram algumas partes da pista e duas alterações no traçado para possibilitar uma corrida mais emocionante e segura. Neste evento foi reunido o maior público já presente numa prova de automobilismo no Ceará com mais de 53 mil pessoas. A reforma ampliou as saídas das curvas e as áreas de escape como o aumento das arquibancadas e melhorias na área dos boxes. A pista atual possibilita 3 traçados diferentes. A Fórmula Truck usou o traçado mais curto, de 1.780 metros e correu no sentido horário. O vencedor de ponta a ponta foi Pedro Muffato após 36 voltas.

No ano de 2007 estrearam duas novas categorias de automobilismo a CTM2000, e a Fórmula V1.8. A CTM2000 é uma categoria que realiza suas provas em conjunto com a Turismo multi marcas e a Fórmula V1.8 corre junto a categoria Super Turismo. Em 2008 foi confirmada pela organização dos campeonatos o retorno de provas de duas categorias nacionais: Pick-up Racing e Fórmula 3 Sul-Americana.
em 2010 teve um acidente fatal qual matou Daniel Maia

 Provas e Competições

 Grande Prêmio Ministro Mário Andreazza
 6 horas do Ceará
 3 Horas do Ceará
 Arrancada
 CTM2000
 Endurance
 Fórmula 3
 Fórmula Ford
 Fórmula Truck
 Fórmula V1.8
 Motovelocidade
 Pick-up racing
 Stock Car
 Super Turismo
 Turismo
 COPA SOL - MOTOVELOCIDADE (125cc, 250/300cc, 600cc e 1000cc)
 Relizado em 2016

Especificações do Circuito

 Extensão da pista: 3.000 metros;
 Velocidade média: 160 kms;
 Número de curvas: 7 (sete);
 Nomes das curvas: Desespero, Fernando Ary, Grampo, Mr. Bean, Sol, Restaurante, Buriti e Dirce;
 Quantidade de boxes: 32;
 Quantidade de paddocks: 4 (quatro) com capacidade para 800 pessoas;
 Torre de cronometragem com três andares;
 Secretaria de prova;
 Sala de imprensa;
 Sala de direção de prova;
 Sala de comissários;
 Pódio;
 Arquibancada interna para 1.500 pessoas;
 Arquibancada externa para 4.000 pessoas;
 Restaurante;
 Posto para abastecimento;
 Parque fechado para vistoria;
 Estacionamento interno para 60 carros;
 Dois estacionamentos externos para 150 carros.

Ver também

 Kartódromo Internacional Júlio Ventura
 Lista de autódromos por país

Ligações externas
 Federação Cearense de Automobilismo
 Secretarial do Esporte do Ceará sobre o autódromo
 Artigo sobre o GP de Fortaleza 1969 no automobilismobrasileiro.com

Virgilio Tavora
Esporte de Eusébio (Ceará)

redpajama_set_name: RedPajamaWikipedia


RIVA ITALIA is a Loading... luxury yacht, built by Tirreno and delivered in 1961. Her top speed is 16.0kn and her power comes from two 750.0hp Detroit Diesel 12V71TI diesel engines. She can accommodate up to 8 people with 6 crew members waiting on their every need.
She was designed by Cantieri Navali Del Tirreno E Riuniti.


text:
Rosemary Gordon es doctora en filosofía y ejerce como analista junguiana en su consulta privada de Londres. Ha sido miembro influyente de la llamada Escuela de Londres o Escuela evolutiva de psicología analítica.

Es analista didacta de la Society of Analytical Psychology y miembro honorario del Centre for Psychoanalytic Studies de la Universidad de Kent. Fue editora del Journal of Analytical Psychology entre 1986 y 1994.

Obra
Ha publicado entre otros Dying and Creating: A Search for Meaning (1978) y Bridges: Metaphor for Psychic Processes (1993).

Referencias

Bibliografía

Analistas junguianos


The Tomee Power AC Converter for Xbox 360 Slim allows you to use your original Xbox 360 AC Adapter to power your Xbox 360 Slim. Connect this converter to your original Xbox 360 power supply, then connect the other end into your Xbox 360 Slim, and you are able to power up your console. The Tomee Power AC converter is an easy solution to replacing a damaged or missing AC Adapter.


text:
The small sign Yankees' Miguel Andujar gamble is paying off
By Dan Martin
March 10, 2019 | 11:31pm
Yankees legend to be featured on new stamp
Yankees agree to deal with former Cy Young winner
Yankees give Aaron Judge, Gary Sanchez a raise for 2021
LAKELAND, Fla. — Phil Nevin started 463 games at third base during his 12-year major league career, so while infield coach Carlos Mendoza has been charged with helping Miguel Andujar improve his defense at third, Nevin watches the 24-year-old closely, as well.
That's what Nevin was doing in the bottom of the third against the Tigers on Sunday with Detroit's Jordy Mercer at the plate against Danny Coulombe.
"I was keeping my eye on him at that moment,'' said Nevin, who was managing the split squad to a 2-2 tie against the Tigers at Joker Marchant Stadium while Aaron Boone was back in Tampa with the other squad. "[Mercer] is a pull hitter."
And Mercer hit a hard grounder to Andujar's right. Andujar stabbed the ball and made a strong throw to Luke Voit at first that the speedy Mercer beat out.
Still, Nevin considered it a positive play by Andujar, who has said his primary focus in the offseason was improving his first step on defense.
"His timing and landing have been really good,'' Nevin said. "His feet are underneath him. His first step on that ball — I'm not gonna say he doesn't get to that ball last year, but he's certainly covering more ground.''
Miguel AndujarCharles Wenzelberg
The work began early in the offseason, when Mendoza and Boone visited Andujar in his native Dominican Republic at the Yankees complex, and it continued both with Andujar working on his own and again with Mendoza prior to spring training in Tampa.
"I definitely feel better out there,'' Andujar said through an interpreter before the game. "I feel more prepared for every pitch. I know that's important.''
The Yankees are committed to Andujar at third, as the team mostly sat out the Manny Machado sweepstakes and saw Nolan Arenado sign an extension to stay with the Rockies.
Circumstances can change quickly, but for now, Andujar is the guy.
"He just wants to get better,'' Mendoza said. "When we met with him in the offseason, we never even mentioned Machado. We wanted him to focus on what he was doing and it's paying off. His feet are quicker now.''
And perhaps the play he made Sunday will give the Yankees more optimism that Andujar can succeed at third.
"It's noticeable, especially in the last week, that he's applying what he did over the winter and the first few weeks of spring training,'' Nevin said. "The results are coming.''
Miguel Andujar reacts to Nolan Arenado deal with wide eyes
LAKELAND, Fla. — Miguel Andujar's eyes widened when asked what...
Andujar also added two opposite-field hits, including a double to right in the seventh.
"He's using the whole field, going the other way,'' Nevin said. "That's him right there, a lot of extra-base hits."
He had 58 of them a year ago and an OPS of .838 after grabbing the everyday job thanks in part to Brandon Drury going down early in the season.
Andujar said he'd like to be more consistent at the plate in 2019, although outside of a 17-game stretch from late April to mid-May when he struggled offensively, Andujar was among the Yankees' steadiest hitters.
That wasn't enough to keep him on the field, though, in their season-ending loss to the Red Sox in the ALDS, as the Yankees went with Neil Walker at third.
"I can't predict the future, but I want to be out there and to give the best I have,'' Andujar said. "That's the mentality.''
Filed under manny machado , miguel andujar , new york yankees , nolan arenado , phil nevin , 3/10/19
The sad reality for Mets' new phenom
No games today


text:
UN Warns Islamic State About Crimes Against Humanity
This image posted on a militant news Twitter account on June 12, 2014 shows militants from the al-Qaida-inspired Islamic State, formerly known as the Islamic State in Iraq and the Levant (ISIL), raising their flag at an army base in Ninevah Province,
The United Nations Security Council has warned the Islamic State extremist group that it could be held accountable for crimes against humanity for its persecution of minorities in Iraq.
The Sunni Muslim group took over huge swaths of northern and western Iraq in June, declared the formation a "caliphate" and killed or forced out minority groups in the regions it controls.
In a statement late Tuesday, the Security Council said the group poses a threat, not only to Iraq, but Syria, where it is also fighting, as well as to "regional peace, security, and stability."
The statement said "widespread or systematic attacks against any civilian populations because of their ethnic background, religion, or belief may constitute a crime against humanity, for which those responsible must be held accountable."
Specifically, it raised the plight of Iraq's Yazidi community, which practices an ancient faith linked to Zoroastrianism. The Islamic State group last week said all Yazidis, whom it views as infidels, must convert to Islam or face death.
Thousands of Yazidis have since fled Iraq's Nineveh province and are now hiding from the Islamist group in the desolate Sinjar Mountains in northwestern Iraq, where they face starvation.
The Security Council condemned these attacks, as well as those against Christians and other minorities, "in the strongest terms." It called for Iraqi leaders to overcome political divisions and form an inclusive government that can deal with the country's challenges.
The statement also urged U.N. member states to implement sanctions and an arms embargo on the Islamic State and those with which it is associated.
Kurdish Forces Suffer Major Losses Against Islamic State
Sunni insurgents capture Mosul Dam, oil field, two towns, inflicting first major defeat on Peshmerga forces, leading to questions of their effectiveness
Shoura - An Experiment in Reconciliation in Post-Islamic State Iraq
VOA News About Iran


HOTEL MAMATA Vijayawada is a hotel with long standing record for excellent service & tasty food. The hotel provides accomodation which is visually stunning and contemporary in looks. It has all modern amenities and luxury with value for money. The hotel is located at eluru road, opposite old bus stand which is at the heart of the city and its only moments away from the city's commercial shopping and entertainment business. Hotel Mamata has 30 air-conditioned guest rooms, with amenities such as LCD TV, Self-Controlled A/c and Telephone Provided with work space, WIFI high speed Internet access, aimed for business and leisure which suits a range of budgets, each with its own unique decor. The Hotel also provides laundary service, Parking facility, room service. We also have multi-cuisine restaurant (Indian, Tandoori and Chinese) and Banquet hall which can hold about 100 guests. It has also a bar on the top floor.
Computer on Request, Currency Exchange, Travel Counter, Banquet Facilities, Parking, Catering, Airport Transportation, Business Facilities, Wedding Services, Family/Child Friendly.
Shower Caps, Child Care, Desk, Climate Control, Room Heater, Bottled Water in Room, Moisturiser, Refrigerator Room, Electronic/Magnetic Keys, H/C Water.
User reviews for "Mamata Hotel Vijayawada"


In today's society, high-heeled shoes are a woman's weapon. Every woman has at least one pair of these shoes in her closet making the shoe industry one of the most profitable in the fashion world. But this wasn't always the case.
High heels have a long and interesting history tracing as early as the 10th century as men's wear. Here is a short breakdown of the history of high-heeled shoes.
Shoes with high heels were first worn by men as riding shoes. Beginning from the 10th century, men born in cultures with strong horseback-riding traditions wore high-heeled boots. These shoes helped their feet have firmer grip on the stirrups to avoid falling.
One example of a group of men who first wore high heels is the Persian cavalry. And through the conquests of the Persian empire, the shoe style was able to spread in Europe where they eventually came to be associated with the upper class.
In 17th century Europe, both men and women wore high heels. At the time, these shoes were more of a status symbol rather than the gendered fashion choice that they are today. It is worth noting that royalty was one of the biggest fans of high heels with France's Louis XIV wearing the shoes to reiterate his 'aristocratic masculinity'. Catherine de Medici also wore them as a fashion statement and to look taller and more imposing. Queen Mary I of England also wore them for the added height.
It would take another century for high-heeled shoes to become exclusive women's wear. As the 18th century began, high-heeled shoes designs began to have a gendered distinction with men's shoes being broad and sturdy while women's shoes were designed to be tapered. And eventually men gave up wearing the shoe style altogether due their impracticality. This decline is connected to the overall fall of the frivolous culture that France's pre-French Revolution aristocracy was known for. After that, wearing high heels fell out of fashion for a really long time.
Jumping to the 20th century, high-heeled shoes are back in vogue as women's wear. Although a preference for shoes with relatively 'shorter' high heels can be seen across the decades. For example, heels with one to two inches of added height were preferred by women during the 1990's and 1960's. Today, heels come in a wide variety of heights and designs. Terms have also been developed to describe a shoe's specific heel height. Kitten heels refer to shoes with 1.5 inches of heel height, a stiletto is a shoe with around five inches of heel height and platform heels can reach up to six inches or more.
There has been debates over the recent decades on the possible negative effects of wearing high heels on women's health with heels getting a politicized aspect. Some critics have even called high heels as torture devices and even began lobbying for the banning of mandatory high heel policies imposed on female sales associates at department stores.
Some of the proven side effects of long-term wear of high heels are sprains, foot pain, back pain and other foot fractures and deformities. But despite these, the high heels continue to be in vogue with celebrities and ordinary women rocking them. Designer high heels also continue to be coveted pieces for women today.
High-heeled shoes have come a long way from their origins as riding shoes worn by men in earlier times. Over the centuries, they've become the symbol of aristocracy and evolved to what we know them to be today.


text:
Ohio Sec. of State Frank LaRose signs and certifies the results of the Nov. 3 presidential election on Friday. (Submitted photo)
Ohio presidential results are certified
Published 2:08 pm Tuesday, December 1, 2020
LaRose says voting was more secure and accessible than ever
COLUMBUS – It's official. Donald Trump won the Buckeye State.
Ohio Sec. of State Frank LaRose certified the official results of the 2020 presidential general election on Friday.
LaRose's signature marks the completion of the official canvass and certifies winners in the 2020 General Election.
Data was collected by the Ohio Secretary of State's office from the official canvass conducted and submitted by Ohio's 88 county boards of elections.
The Secretary of State conducted a precinct-by-precinct review of the data prior to certification. A list of all 88 county boards of election is available by clicking here.
LaRose said it was the state's most accessible and secure election ever.
The nearly 6 million votes cast were 200,344 more votes than the all-time record of 5,773,777 set in the 2008 general election.
The record 74 percent turnout surpasses the average of the presidential general election average from 2000-2020 of 65 percent.
LaRose said, "despite partisan fearmongering," voting by mail was reliable.
His office said he worked closely with the United States Postal Service to provide for the successful delivery of election mail throughout the election.
While he did not amass the 270 electoral votes nationally to be re-elected, President Donald Trump carried Ohio, 53.3-45.3 percent over former Democratic Vice President Joe Biden, winning the states 18 electoral votes.
Biden's national win marks only the third time in 75 years that a presidential victor has won without carrying Ohio, which has long been considered a bellwether state.
Democrat John F. Kennedy lost the state to Republican Vice President Richard Nixon in 1960, and Democrat Franklin D. Roosevelt, who successfully won a fourth term, failed to carry it to Republican Thomas Dewey in 1944.
At noon on Dec. 14, the members of Ohio's Electoral College will gather in the Senate chamber of the Statehouse to cast their electoral votes for president and vice-president. This occasion marks the 55th meeting of the Ohio Electoral College since statehood in 1803.
Counties will continue the post-election audit process, further ensuring Ohioans have faith in the integrity of the electoral process and that every valid vote is counted.
State Democratic chair stepping down
Pepper had been in position since 2014 CINCINNATI (AP) — Ohio's Democratic Party chair is stepping down after six years... read more


text:
Q: How to group items on plotly boxplot I've reviewed the boxplot documentation and the workaround for supplying precomputing statistics for boxplots (https://plot.ly/~chris/18051/#code). Yet I still cannot achieve the following. Does anyone know how to achieve this grouping and coloring of boxes on a single plot?

A: Have a look here: https://plot.ly/python/box-plots/ under "Grouped Box Plots".
import plotly.plotly as py
import plotly.graph_objs as go

x = ['day 1', 'day 1', 'day 1', 'day 1', 'day 1', 'day 1',
 'day 2', 'day 2', 'day 2', 'day 2', 'day 2', 'day 2']

trace0 = go.Box(
y=[0.2, 0.2, 0.6, 1.0, 0.5, 0.4, 0.2, 0.7, 0.9, 0.1, 0.5, 0.3],
x=x,
name='kale',
marker=dict(
    color='#3D9970'
    )
)

As you can see, the length of the list containing the x-values used to groupby later on matches the length of the list of of y-values. The first 6 correspond to day 1 the other to day 2.
further explanation can be found here:
Plotly boxplot: groupby option?
In short, you have to create/compile the x values of the boxplot according to the desired outcome. A simple groupby/hue option like in seaborn is missing unfortunately.


text:
A 24 Hour Service, every day of the year
Funeral Announcements
What you need to know in times of Bereavement
Pre-paid Funeral Plans
Religious Requirements
Coffins/ Caskets/ Urns >
Traditional Coffins
Alternative Coffins
Urns/Keepsakes
Mourning Stationary
Bespoke Requests
What You Need to Know in Times of Bereavement.
1. Informing the Doctor
Inform the Doctor that the death has occurred as soon as possible. He/she may write the Medical Certificate of Death when he/she visits the house, or may request you attend the surgery for this purpose.
When death occurs in hospital
When death happens in hospital the procedure is very similar, however you apply to the hospital for the Medical Certificate of Death and not your family doctor.
The Coroner
In cases where the death has been reported to the Corner, the Coroner and his/her officers will work in your interest. A doctor will not issue a Medical Certificate of Death in this case. The Coroner will release the deceased once his/her enquiries are complete, and we are able to inform you when this will take place.
2. Registering the Death
Who can register?
- Close relative of the deceased
- Relative living in the area where the death occurred
- A person present at death
- The person arranging the burial/cremation
What Documents are required?
- Medical Certificate of Death
- Medical Card if available or;
- Birth Certificate & information surrounding date of birth
What Information is required to register?
- Date and place of death
- Full name of deceased (maiden name if applicable)
- Date and place of birth
- Occupation and home address
- If married, full name and occupation of surviving spouse
- The Green Certificate is for us, the funeral director
- Social Security Certificate to be handed in at the D.S.S Offices with any pension books
- Copies of Entry of Death for bank, insurance, solicitors (at a cost)
3. Obtaining Probate
When someone dies somebody has to deal with their estate (the money, property, and possessions left) by collecting all the money, paying any debts and distributing the estate to those entitled.
The Probate Registry issues the document which is called a Grant Of Representation.
There are three types of grant:
- Probate issues to one more of the executors named in the will
- Letter of Administration (with will) issued when there is a will, but no executor named or unable to deal with the estate
- Letters of administration issued when the deceased has not made a will or it is not valid
Why is this grant necessary?
Organisations holding money in the deceased's name need to know to whom the money is to be paid. The distribution of the estate is the responsibility of the person named on the deed. A grant may not be needed if the deceased's money will be released without the holder seeking a grant, when the amount held is small and there are no complications.
Consult a Solicitor
In most circumstances, it is advisable for you to consult a solicitor both to relieve you of any worries and to take control of Will, problems of intestacy, outstanding debts, grants and letters of administration. A solicitor could save you a great deal of unnecessary trouble and eventually save you money.
If it is known that a Will was made, it is important that the contents be ascertained as soon as possible after the death as it may contain instructions regarding the funeral arrangements. A Will may be amongst personal papers, or with the bank or solicitor for safe keeping. If a solicitor has been consulted by the deceased in the recent past it is important that you contact them without delay.
For any further information, advice or support on anything outlined above please
Additional Options Price List
Crematoria Price List
Coffins/ Caskets/ Urns
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Looking for Cracked Teeth in Pace? For an appointment at Pace Dental Care call our office today at 850-304-0874 or make an appointment today.
If you think you have a cracked tooth, contact Pace Dental Care at 850-304-0874 without delay. Early treatment can save your tooth.


text:
Q: C# Dropdown items 0 - 100 without adding each item? Sorry if this is a dumb question ... I'm just trying to learn the best way to do it.  Basically I want to have a dropdown list with values blank and then 0 - 100.
Whats is the best way to do this without manually entering each one.  I imagine it is through some form of a list bound to the dropdown.
Thankyou in advance for the help.

A: You can just use a for loop.
myControl.Items.Add(new ListItem(string.Empty, -1));
for(int j = 0; j < 100; j++)
{
    var newOption = new ListItem("Item #" + (j + 1).ToString(), j.ToString());
    myControl.Items.Add(newOption);
}

A: If you bound the list (array, collection, etc...) as datasource into the dropdown (winforms? webforms?) there always will created items. If you don't want add each item manualy, you can do it with code:
// this code is for winforms
dropDown.Items.Clear();
dropDown.Items.Add( string.Empty );
for(int i = 0; i <= 100; i++ ) {
    dropDown.Items.Add( i.ToString() );
}

A: For instance in asp.net MVC:
Controller:
ViewData["list"] = new SelectList(Enumerable.Range(0, 101)
                .Select(p => new SelectListItem() { Text = p.ToString(), Value = p.ToString() }));

View:
<%=Html.DropDownList("numbers", ViewData["list"] as SelectList, "Select a number") %>

A: Here is one way of doing it:
ddl.Items.AddRange(Enumerable.Range(0, 100).Select (e => new ListItem(e.ToString())).ToArray());

A: If this is webforms:
I imagine you want something like this in your page_load event.
if(Page.IsNotPostBack)
{
    DropDownList1.Items.Add(new ListItem("",""));
    for(int i = 0; i <= 100; i++)
        DropDownList1.Items.Add(new ListItem(i.ToString(), i.ToString());
}

A: ddl.DataSource = Enumerable.Range(1, 100);
ddl.DataBind();

A: combo.Items.Add("")
for (int i = 0; i < 100; i++)
  combo.Items.Add(i)

Also, consider using a NumericUpDown control with a maximum value of 100. This won't give you the blank choice, but is an arguably nicer usability choice.

A: Create a utility to generate your values:
public class Utils
{
    public static IEnumerable<string> GetSequenceEntries(long maxValue)
    {
        yield return string.Empty;

        for(int i=1; i<=maxValue; i++)
        {
            yield return i.ToString();
        }
    }
}

Then for a WinForms application bind it similar to this:
private void Form1_Load(object sender, EventArgs e)
{
    comboBox1.DataSource = Utilities.Utils.GetSequenceEntries(100).ToList<string>();
}

Or for ASP.NET bind it like this:
protected void Page_Load(object sender, EventArgs e)
{
    ddl1.DataSource = Utilities.Utils.GetSequenceEntries(100);
    ddl1.DataBind();
}

A: vb:
For i As Integer = 0 To 100
                ddlperiod.Items.Add(i)
            Next


The big bag of boys is back and talking about all their secret kissing stories. Join us as we recap some games we've been playing, some series we've missed out on, debate skid marks vs poop farts, and tuck ourselves in for some real man stuff! Moms hate it! Stepdads can't stand it! It's the Games Gone Awry podcast.


The Year 2014 marked to be a highly significant year for BirthKuwait as it successfully marked one of its key milestones - conducting the 'Birthing with Confidence in the GCC' which was the first conference to be held in this region of this kind.The exposure and growth which was established from this was remarkable because not only we had trainees from Kuwait, we had some coming in from neighboring GCC countries hence proclaiming the success of the mission of targeting the whole region as intended.
BirthKuwait managed to attain many loyal sponsors, some of which are continuing to collaborate with the branches and affiliates of BirthKuwait. And we have more sponsors and partners on board, post conference, all as a result to the success accomplished.
Most fruitful outcome of this conference was the establishment of Breastfeeding Support Program (BFSKW), the first of its kind in Kuwait. Offering monthly workshops in Arabic and English which have acclaimed great acceptance and seats get full weeks in advance. They have launched a Breastfeeding Support Hotline which provides daily support to moms via phone calls and messages as well as home visits.
Alongside this many private and public hospitals have expressed an interest in becoming more supportive of breastfeeding and invested in this goal by getting their staff trained hence many nurses and doctors were trained by BK to become Doulas, Breastfeeding Counselors, Lamaze Childbirth Educators and Lactation Educators during our conference.
-Establishment of BFSKW- providing workshops, hotline support, home visits and Breastfeeding awareness.
-@bfskw Instagram account having a rapid growth of followers and people benefiting from informative bilingual posts.
-Childbirth Education classes conducted privately and in groups.
-Significant Growth in the number of volunteers.