US Representative Joseph P. Kennedy III has earned stock value of up to $434,999 from investments in Gilead Sciences Inc., the manufacturer of a controversially priced hepatitis C drug, Sovaldi, that many of his constituents are struggling to afford, according to public financial disclosures and campaign finance records.
Kennedy, who is the lone high-level Massachusetts politician who has invested in Gilead, earned between $15,001 and $50,000 in capital gains after selling part of his stock in 2014, according to a transaction report he filed. He purchased the stock in 2012, in the midst of hepatitis C's overwhelming spread through Massachusetts. After the state reported just 10 cases in 2011, the number skyrocketed to 174 in 2013, according to the CDC.
His holdings in Gilead, as of the end of 2015, totaled between $180,004 and $450,000, according to financial disclosures. (Lawmakers are not required to report the exact value of their assets, but in ranges instead). Of 23 congressmen with shares in Gilead, Kennedy currently holds the most.
In a 2015 cost trends report from the Massachusetts Health Policy Commission, researchers revealed that high hepatitis C rates, combined with Sovaldi's pricing, was becoming a strain on the state's budget. Last December, the US Senate Committee on Finance found in its investigation of Gilead that the company had a "revenue-driven" pricing strategy. According to the committee's report, state Medicaid programs across the country spent $1.36 billion on Sovaldi in 2014, before rebates, to reach just 2.4 percent of patients.
Hepatitis C is heavily linked to opioid abuse. According to a CDC survey, between 40 and 50 percent of those with the disease who responded in 2012 said opioid use contributed to their contracting it. This raises the specter that Kennedy, through his investment, could be indirectly benefiting from the opioid crisis.
In Kennedy's district overall, the number of opioid-related deaths increased 29 percent between 2012 and 2014, according to the Department of Public Health.
Kennedy has been outspoken about the opioid crisis since joining Congress in 2012. In 2015, he helped introduce a bill aimed at tracking prescription drugs to curb abuse.
Kennedy's shares in Gilead may also pose a political conflict with Attorney General Maura Healey. On Jan. 22, Healey wrote a letter to Gilead requesting that the pharmaceutical company reconsider its pricing — $1,000 per pill of Sovaldi and $84,000 for a complete treatment — so that public and private insurers can affordably deliver the drug to patients.
Craig Holman from the political advocacy group Public Citizen said Kennedy should rethink his investment.
This story was produced as part of Maggie Mulvihill's Boston University Journalism Research course.


text:
package com.zhy.utils;

import java.util.List;

import android.content.Context;
import android.graphics.drawable.BitmapDrawable;
import android.view.MotionEvent;
import android.view.View;
import android.view.View.OnTouchListener;
import android.widget.PopupWindow;

public abstract class BasePopupWindowForListView<T> extends PopupWindow
{
	/**
	 * 布局文件的最外层View
	 */
	protected View mContentView;
	protected Context context;
	/**
	 * ListView的数据集
	 */
	protected List<T> mDatas;

	public BasePopupWindowForListView(View contentView, int width, int height,
			boolean focusable)
	{
		this(contentView, width, height, focusable, null);
	}

	public BasePopupWindowForListView(View contentView, int width, int height,
			boolean focusable, List<T> mDatas)
	{
		this(contentView, width, height, focusable, mDatas, new Object[0]);

	}

	public BasePopupWindowForListView(View contentView, int width, int height,
			boolean focusable, List<T> mDatas, Object... params)
	{
		super(contentView, width, height, focusable);
		this.mContentView = contentView;
		context = contentView.getContext();
		if (mDatas != null)
			this.mDatas = mDatas;

		if (params != null && params.length > 0)
		{
			beforeInitWeNeedSomeParams(params);
		}

		setBackgroundDrawable(new BitmapDrawable());
		setTouchable(true);
		setOutsideTouchable(true);
		setTouchInterceptor(new OnTouchListener()
		{
			@Override
			public boolean onTouch(View v, MotionEvent event)
			{
				if (event.getAction() == MotionEvent.ACTION_OUTSIDE)
				{
					dismiss();
					return true;
				}
				return false;
			}
		});
		initViews();
		initEvents();
		init();
	}

	protected abstract void beforeInitWeNeedSomeParams(Object... params);

	public abstract void initViews();

	public abstract void initEvents();

	public abstract void init();

	public View findViewById(int id)
	{
		return mContentView.findViewById(id);
	}

	protected static int dpToPx(Context context, int dp)
	{
		return (int) (context.getResources().getDisplayMetrics().density * dp + 0.5f);
	}

}

redpajama_set_name: RedPajamaGithub


text:
December 8Bates Delays Module C to Feb 17, Cancels Short Term 2021
Orientation Issue 2020
Special Election Issue 2020
Forum Focus
Commons Recipes
The Bates Student
Men's Cross-Country Impresses in Wisconsin at NCAAs
The men's cross country team started their Thanksgiving break with a short, but exciting, trip to Winneconne, Wis. for the Division III NCAA Championships. The 8-kilometer race was held on Nov. 17 at the Lake Breeze Golf Club and comprised a field of 280 nationally qualified collegiate runners. This trip marked the men's cross-country team's first presence at the NCAA Championships since 2013, the sixth experience overall, and the first experience traveling with the women's team since 2012.
The men's cross country team poses above the NCAA at the Lake Breeze Golf Club after racing and finishing 26th.
"Finding out we were going was a bit of a surprise," Tucker Barber '21 said, a member of the competing NCAA squad. "It went from the initial shock of finding out to the hurry of getting affairs in order to leave on Wednesday. It was hugely exciting."
The Bobcats secured a spot at the NCAAs with their impressive results at the NESCAC and Regional Championships. At NESCACs, the Bobcats saw a fourth-place finish and at Regionals earned sixth-place, one point behind Tufts. In both meets, runners competed in grueling conditions which highlighted the team's perseverance, grit, and strength. Following these outstanding accomplishments, the Bobcats capped off the 2018 season by fighting through blistering and frigid temperatures and finishing 26th out of 32 teams at NCAAs. Bates scored 604 total team points, three points behind Tufts and nine ahead of Claremont-Mudd-Scripps.
"I think everyone on the team was a little unsure of what to expect going into NCAAs, and while some things did not go the way we wanted for each of us, we still put together a good race," Barber said.
"NCAAs was a totally different experience and unlike any race," senior captain Henry Colt said. "Getting to travel with the women's team, traveling to the Midwest, and experiencing a huge championship race was the perfect culmination of this year. Our trip reminded the team why we strive for this every year."
As for individual scorers, James Jones '20 placed 28th out of 280 runners with a time of 24:53.8, earning All-American honors, a distinction given to the top 40 runners. Jones is the 15th All-American runner for the men's cross-country program. The last Bobcat to achieve this accomplishment was alum Allen Sumrall '16 in 2015.
Following Jones was Justin Levine '20, who finished 170th and covered the course in 25:57.9. First-year Bart Rust '22 placed 193rd, followed by Barber '21 and Colt in 207th and 215th respectively. Seniors Mark Fusco '19 and Nico Johnson '19 were the two displacers, finishing in 240th and 249th.
"We were ranked 29th and placed 26th. The team could have definitely done better, but it just leaves the team hungry to go back next year," Colt said.
Overall, this team has seen a successful 2018 season. As with any collegiate team, they have experienced a balance of challenges and victories. Tufts proved to be their toughest competitor throughout the season.
To recap the season, on Sept. 15 the Bobcats lost to Tufts by four points at their home course. The team saw their toughest meet of the year at the Connecticut College Invitational on Oct. 13 with a 14th place finish out of 27 teams. Here, they lost to Amherst, Williams, Middlebury, and Tufts.
They bounced back on Oct. 27th at the NESCAC Championships where the Bobcats were seeded eighth out of 11 teams and finished fourth. Tufts placed seventh at this meet. They continued this success on Nov. 10 with their 6th place performance at NCAA Regionals.
Ultimately, regardless of the outcome of each meet, the team has shown tremendous commitment. By securing a spot at the NCAAs, men's cross country has capped off a remarkable season and will strive to continue this success as they begin to transition to track.
"It has been a rollercoaster of a season. There were tough races in the middle but this season was characterized by bouncing back and not doubting ourselves," Colt said. "Our year looked more like a graph of peaks and valleys – it was definitely a wild ride."
All comments must have an attached name and email. Please direct comments to the content of the article; attacking writers in any way, shape or form will not be tolerated. Any comments which do not meet these requirements will not be published.
The 2020 Presidential Election from a Sociological Perspective
Students Demand Accountability Following Instagram Post
Results of The Bates Student Winter Calendar Change Survey
"The Haunting of Bly Manor": It's a Love Story
Gomes Chapel Reopens, Continues to Provide Space for Meaningful Connection
How satisfied are you with Bates' new Winter semester plan?
Very Unsatisfied
Tweets by BatesStudent
Fall Athletics in Review: How Did Athletics Fare with COVID-19?
#BobcatsAllIn Promotes Voter Registration
Dance at Bates: Where Does it Fit In?
What Happens When Athletes are Quarantined?
Bates Suspends Athletic Practices Friday Due to COVID-19 Violations
Bates Cross Country Virtual Alumni Meet Goes Off Without a Hitch
Peder Bakken '21: 'Backbone of Bates Soccer'
Bryson DeChambeau Wins the US Open, Signaling a New Era in Golf
Sports Medicine Adjusts to New COVID-19 Protocols
New Merrill Fitness Center – A Change for the Better?
The Voice of Bates College Since 1873

redpajama_set_name: RedPajamaCommonCrawl


text:
Danish police puzzled by Little Mermaid message
Updated / Friday, 3 Jul 2020 14:52
Police examine the scene in Cophenhagen
The Little Mermaid statue in Copenhagen, the city's most famous monument, has been vandalised but police and commentators were puzzled as to who might have done it and what their message really is.
"We can confirm that The Little Mermaid has been vandalised some time before 9am this morning," Copenhagen police said in a statement.
"An unknown person has written the words 'Racist Fish' on it. We are investigating the case."
The Little Mermaid, inspired by a character in Danish poet and author Hans Christian Andersen's 1837 fairytale of the same name, is a 175kg statue by sculptor Edvard Eriksen.
The statue has been vandalised numerous times over the years, including when the mermaid's head was stolen in 1964 and 1998, as well as when an arm was cut off in 1984.
Often the vandalism is tied to a political message and in January someone painted "Free Hong Kong" on the same rock.
The meaning of the apparent racist accusation has however, so far, left some scratching their heads.
"Of course in general with literary works, you can read them with various glasses," Ane Grum-Schwensen, an expert employed by the HC Andersen Centre at the University of Southern Denmark, told broadcaster TV2.
"However, I do find it a little difficult to see, what would be especially racist in the adventure The Little Mermaid," she added.
According to police other statues around Copenhagen have also been vandalised with "various phrases". One of missionary Hans Egede, who launched Lutheran mission efforts to Greenland, and one of Mahatma Gandhi in the northwestern part of the city.
Police also said that on 16 June, someone had written "racist" on a statue of Danish King Christian IV, who ruled between 1588 and 1648.
Statues of historical figures in many countries have come under fire from activists protesting racism following the 25 May death of George Floyd, an African-American killed by a white police officer in Minneapolis in the US.
News Lens
newslens


This AWESOME set of grips has a TYRANOSAURUS T-REX engraved on them, in front of a section on the back/bottom of stone wall engraving for texture.
Shown in the picture with the DYED BLUEstain, you can choose from any in the list to suit your taste.
These grips will add a TON of character to your MICRO 9.
These are test fit on a Kimber Micro 9, although due to some firearm manufacture discrepancies, a small amount of end-user fitting may be necessary. Also, the 'display' guns, and screws shown in the pictures are not included.


70%-80% of my photographs are taken with this simple setup. My Nifty Fifty has been my go-to lens ever since college, where I spent my first two years working almost exclusively with a Pentax K1000 that came with a 50mm lens which has never been switched out. I grew to learn that framing by heart. The only other lens I own for my 5DIII is an 85mm f/1.8, used mostly when photographing concerts or BTS on a film set.
I like working with prime lenses because they force me to do the work and the physically move around the environment. If I want a wide shot, I have to run the distance across the field, or if I want an intimate portrait, I have to get so close the model's breath will fog up the lens. This doesn't just create better images than if I was able to shift from wide to telephoto at the twist of a lens, but it create a stronger connection between me and the subject. It fosters an intimacy and trust. Forcing myself to physically move around three dimensional space also opens me up to possibilities that I otherwise wouldn't discover.
My high school art teacher was a sculptor and that truly has informed so much of my philosophy and approach to shooting. When I'm working I'm almost always moving and shifting, changing angles and approaches and planes of focus, almost as if I am chipping away at stone, revealing to myself what lies within.


text:
Kharash () is a sub-district located in Huth District, 'Amran Governorate, Yemen. Kharash had a population of 669 according to the 2004 census.

References

Sub-districts in Huth District

redpajama_set_name: RedPajamaWikipedia


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"Complete mitochondrial genome of the catophragmid barnacle Catomerus p" by Benny K. K Chan, Lucia Aguilar et al.
Chan, B. K. K., Aguilar, L., Hou, B., Kang, H. & Kim, S. (2018). Complete mitochondrial genome of the catophragmid barnacle Catomerus polymerus (Cirripedia, Thoracica, Balanomorpha, Catophragmidae). Mitochondrial DNA Part B: Resources, 3 (2), 1286-1287.
The family Catophragmidae is one of the lower balanomorphs from traditional and recent multiple mitochondrial and nuclear markers molecular analysis. Here, we characterized the first mitogenome of the catophragmid barnacle Catomerus polymerus, which was 15,446 bp in length with a 68.3% AT content. The mitogenome had the typical pancrustacean gene arrangement, which was identical to the mitogenome configurations of the chthamalid Octomeris sp. and pachylasmatoid Eochionelasmus ohtai. On the mitogenomic tree, the catophragmid Catomerus polymerus formed an independent branch that was basal to the members of the superfamilies Tetraclitoidea and Balanoidea, which was inconsistent with previous findings.


These space themed writing prompts are designed for emergent writers. The simple preschool writing prompts will give new writers confidence. They are out of this world!
Do you have a preschooler who loves to write? They'll love these beginner writing prompts that are out of this world! These space prompts are perfect for young writers.
Each one has a space-themed writing prompt and a picture to color. Preschoolers who are comfortable writing can write their own stories. If not, let your little ones dictate their story for you to write.
Either way, these preschool writing prompts will help your preschoolers' imaginations soar!
If your preschooler is very creative, let him draw a picture on the back of the writing prompt to illustrate his story. Or, draw the picture on a separate page so that both the prompt and the illustration can be displayed at the same time.
These prompts are perfect for older preschoolers, but they'll work well with kindergarten and first-grade writers, as well.
You'll receive seven unique writing prompts, a word bank, and an extra fully lined page for your wordy writers.
They can use the word bank cards if they want. These cards can help spark their imaginations or help them spell words correctly. However, they're optional. If your child will be intimidated by them, feel free to leave them out.
Fill your book basket with a great collection of preschool space books. Most of these books can be found at your local library or used bookstore. If you have a hard time finding them, you can order them through my Amazon affiliate links by clicking the images below.
• National Geographic Little Kids First Big Book of Space | The book will explain basic concepts of space, beginning with what is most familiar to kids and expanding out into the universe.
• The Magic School Bus Lost in the Solar System | The field trip to the planetarium is foiled when the museum turns out to be closed, but Ms. Frizzle saves the day. The Magic School Bus turns into a spaceship and takes the class on a trip zooming through the atmosphere, to the Moon, and beyond!
• Hello, World! Solar System | Told in clear and easy terms and featuring bright, cheerful illustrations, Hello, World!makes learning fun for young children. And each sturdy page offers helpful prompts for engaging with your child.
Download your preschool writing prompts.
Click the image below. Sign up for my newsletter, and you'll receive this freebie as a thank you! Enjoy!


Barcelona assistant manager Jordi Roura was delighted at the understanding shown between Lionel Messi and David Villa as they combined for all of Barca's goals in the 3-1 win over Rayo Vallecano on Sunday.
There had been suggestions in the past that the two didn't get on, but Roura laughed off those claims and hailed the connection they have on and off the field.
"This is something I have heard many times and it has always seemed absurd to me," he told reporters.
"There has never been a motive to say this and the relationship now is the same as it was a few months ago, that is to say it is very good.
Villa was particularly bright as he started for the fourth consecutive game for the first time since breaking his tibia 15 months ago and he opened the scoring after Messi had unlocked the Rayo defence on 25 minutes.
The Spanish international then turned provider for Messi to score twice either side of the break and after also scoring in the comeback against AC Milan on Tuesday, Roura believes his confidence has fully returned after a difficult start to the season.
"Every game is its own story and this week we have seen that Villa was fundamental for us.
"David has extraordinary quality and to have played so well and scored in such an important game as that against Milan was a huge confidence boost.
The only downside for Barca was an injury to Adriano that is set to keep him out for four to six weeks.
And Roura is worried that with captain Carles Puyol also out for the forseeable future, he has little in reserve when it comes to defensive options to compensate for the Brazilian's absence.
"It is the negative part of today's game and comes in a four to six week period that will be crucial for us," he said.
Rayo boss Paco Jemez meanwhile was proud of his side's display despite the defeat.
"I am a winner. I don't like to lose but I don't think there has been a prouder coach of his team that I am of mine today despite the fact we have lost.


text:
by Alanna Rodriguez | Oct 22, 2021 | PARTNERS NL
Andrew Park is no stranger to Public Campus Ministry. He has served as a CAMPUS scholar, public campus missionary in Hong Kong, and as a CAMPUS fellow. While fulfilling his one-year internship in packaging, he did not feel fulfilled in his professional role, his one desire was to reach his co-workers.
God opened the door for him to serve as a missionary in Hong Kong after he graduated. While in Hong Kong, a call came for him to serve as the GYC president. When considering this position, he knew it would change his professional trajectory. The time commitment as a GYC president would make it very difficult to work in a professional setting. He prayerfully accepted and came to work with CAMPUS full-time as a fellow.
Andrew and Nichole Park
In the spring of 2021, God began to open doors for Andrew to consider serving in pastor ministry for the Michigan Conference. The official call came to serve in the Vassar and Bay City churches. As Andrew reflected on how God had led him in the past, he knew God was redirecting to pastoral ministry, and he accepted the call.
Here is his reflection, "God may not make things clear immediately, but as He opens doors of providence and we walk through it, He will reveal His will according to His own time and method. Lastly, He knows where we will be of the greatest good according to the capabilities He's given us – we need to trust Him step by step, even if it's not what we would have originally envisioned for ourselves."
God has used Andrew in a mighty way to reach the students at Michigan State University, as well as the friends of the University Church in East Lansing. He and his wife Nichole are missed, but God is so faithful to led them to where He needs them at this time in salvation's history. Please keep them in prayer as they transition. They are not too far from Saginaw Valley State University.
When considering the next call that God may be making in your life, know that even if the story that unfolds is not what we would have originally envisioned for yourself, because He is the best Author. He has a way of writing the most beautiful stories and you can trust Him in the process.
MISSIONARY and OYiM+ GRADUATION APRIL 24, 2021
by Alanna Rodriguez | Jun 2, 2021 | CAMPUS Missionaries, News
Written by Grady Yonas, C.A.M.P.U.S. Fellow, East Lansing
On April 24th, 2021, the collaborative program between the General Conference, Lake Union, and Public Campus Ministry Department of the Michigan Conference, One Year in Mission (OYiM+), officially came to an end. The graduation ceremony was held at the University Church, East Lansing, Michigan. Approximately 100 people attended the service, including Eld. Justin Ringstaff, Michigan Conference Executive Secretary and Pr. Jermaine Gayle, University Church Senior Pastor. Both Program Directors of East Lansing and Detroit, Pr. Leeroy Hernandez and Pr. Steven Conway welcomed the attendees and gave a brief overview of the program, then followed by the Fellows and Missionaries sharing their experience.
The keynote speaker was Pr. Israel Ramos, Public Campus Ministry Director of Michigan Conference and Lake Union. In the message he emphasized that the focus of the CAMPUS and OYiM+ is to help young people to be 21st century missionaries by overcoming their fear and indifference.
The program was then followed by handing certificates to the Missionaries, Joi McClellan, Erika Hernandez, and Upuia Fineaso, and the Fellows, Andrew Park, Grady Yonas, and Bamiji Ibironke. Pr. Steven Conway closed the program with benediction upon them.
Despite the unprecedented situation, God tremendously blessed the program. The determination of the three ladies to join and finish the program has inspired many around them.
We want to thank all of you who have faithfully supported this program. Only eternity can tell the impact it's made. We need missionaries today more than ever. Maranatha.
CAMPUS MISSIONARY BATCH 20
YEAR IN REVIEW SLIDE SHOW


Discussion Why is converting from fastq to uBAM nesessary before preprocessing?
I am brand new to this so please go easy on me. I have just taken over a project where we are going to be doing variant calling on a large number of human samples. I have inherited a number of scripts that are at least a few years old. I decided I wanted to follow the GATK best practices while noting the differences between the them and the scripts I have. I'm currently trying to push a single family (5 individuals) through the pipeline before applying it to all of the other samples I have.
So, first of all, all of my raw data is stored as paired-end reads in fastq format, I have no uBAM files available to me. According to the data pre-processing for variant discovery steps, the "reference implementations expect the read data to be input in unmapped BAM (uBAM) format. Conversion utilities are available to convert from FASTQ to uBAM." So the first thing I did was use FastqToSam to do the conversion yesterday. This is not an insignificant task, I ran each sample for my test family in parallel and it took roughly 5 hours.
I understand the benefit of using uBAM from the get-go (keeping some metadata that is discarded in fastq as described here: https://gatkforums.broadinstitute.org/gatk/discussion/5990/what-is-ubam-and-why-is-it-better-than-fastq-for-storing-unmapped-sequence-data), but I don't see the benefit of doing this conversion if the first step of the alignment is to convert this uBAM back to fastq before running bwa mem and samtools view. The next step would be to use MergeBamAlignments to merge the mapped and unmapped alignments which I guess I couldn't do if I did not do the original fastq->uBAM conversion.
Basically, my question is if the initial conversion from fastq to uBam is necessary or even recommended in this case. I don't see how it could have any added benefit and converting from and to fastq will incur a significant overhead. For what it's worth, the script I inherited simply ran 'bwa mem' on the paired-end reads and piped the output into 'samtools view -bh' to create the aligned BAM file. From here they would move on to the marking of duplicates. If I don't convert to uBAM and then skip the MergeBamAlignments, will that have an impact on me being able to apply the best practices down the line? I want to stick as close to the best practices as I possibly can, but If I can cut out some unnecessary computation time then that would be great.
Merging unmapped bam and mapped bam restores hardclipped bases back into alignment in the form of softclips which may significantly affect your SNP and INDEL discovery, even Structural Variant discovery. Also who wants to loose data when aligning to the reference genome?
@Angry_Panda If you would like to split the fastq file containing data for 1 sample from multiple lanes, you can use the tool that I mentioned earlier, splitReads, to separate a fastq file into multiple based on read groups.
Yes the AddOrReplaceGroups function allows you to change/replace the read group if you wish to do so. One of the advantages of leaving your data separated by lanes is to take into account technical bias across lanes when you use BQSR, for example. Additionally, keeping the reads separated allows for efficiency in analysis times and furthermore, if you plan to use Broad scripts, they require samples to be separated by RG. These are Broad practices that are used.
So the fact that I'm converting from fastq to uBAM in the first place doesn't affect this at all? I would've thought that a lot of the important metadata would've already been lost since I don't have access to the BAM files straight from illumina. However, what you are saying sounds like it would still be worthwhile and would not be possible without first converting the fastq files to uBAM.
Again, I am very new to this so I don't exactly have all of the background knowledge. Thanks again for answering.
You can map your reads to your reference using bwa. you don't need to have anything from illumina other than your raw reads or raw basecalls. So generating unmapped bam and merging that to the first alignment from bwa is to restore all the information and add metadata on the alignment file. After that just continue with merged aligned file only.
Great, thanks a lot. I guess I was just confused as to what the benefit was going from fastq->uBAM->fastq at the start. Correct me if I'm wrong but the benefit comes with the merging of the mapped and unmapped BAMs after alignment which restores some of the data lost during alignment to our aligned BAM file. I think I'm just restating what you've said, I just want to be sure I understand.
Skywarrior, would it not be more straightforward to modify bwa-mem to preserve that information in the first place? FQ -> Bam -> FQ -> Merge is a significant overhead, many hours per genome, yet from this discussion it seems to just be a workaround for some undesired behaviour in bwa-mem. Correct me if I am wrong.
I have looked at the bwa-mem c source code and I understand the preference for a java team to just create a new java tool, but this seems short sighted in the long run.
BWA hardclips reads if there is a significant discordance between the best matching kmer and the read. These hardclips may end up costing you a particular structural variant or a true indel call. Merging unmapped bam and initial alignment restores the hardclips which I know of no solution for that in BWA parameters.
uBAM + initial map --> Picard - Merge.
This may seem like an overhead but a necessary one for me.
That is how the broad best practice workflows operate.
ubam input, converted on the fly to fastq and piped to bwa.
Still fastq is needed for bwa. On the fly conversion of uBAM to fastq is necessary.
Some people can get their data in the form of uBAMs out of their sequencing service but some of us still use the good old bcl2fastq. That's why.
I am trying to follow the gatk4 wdl script offered by board institute github page to make things easier. yes, it takes a list of ubam files as input.
I am trying to transfer NA12891 and NA12892 fastq file to two lists of ubam files which like the list of NA12878 ubam files offered by board.
I was wondering how could we splite the ubam file into a list of ubams like board did?
This is a question for the WDL team and they will be able to answer this question, as it is specific to the WDL script you are using. @SChaluvadi , who is our WDL expert will be able to help you out with this.
@Angry_Panda Can you please share the name and/or link of the wdl script you are referring to?
It work well with the NA12878 small ubam files.
But I cannot find detailed info about the ubam files, such as its fastq, size, sequence depth, read length etc. the same situation for (https://console.cloud.google.com/storage/browser/broad-public-datasets/NA12878/unmapped/). Does Board have some documents about this?
I tried to go through this pipeline with 3 samples, NA12878, 12891 and 12892. It seems like I can download fastq file (1 and 2) from 1000 Genomes Project data. and transfer it to ubam with java -Xmx8G -jar picard.jar FastqToSam \ but I dont know how to broke up it into ubam list via RG like board did to make it can suit for this wdl script.
Also, does board offered some benchmarking dataset for germline-snps-indels pipeline ?
You can derive the RG information from the read names and then continue with the FastqtoSam step. Here is a link that shows how to derive RG fields' information from read names as well as a forum post that has further information on how you can add/replace read group using AddOrReplaceReadGroups. This should help you add read groups to your uBAM such that they will be compatible with the WDL script that you are using.
I am looking into if/how to find more detailed information about the uBAM files that you have pointed to and will get back to you! Can you also elaborate on what you are looking for in way of benchmarking data?
Thx very much for your answer.
I am trying to do it.
I am wondering whether the list of ubams I listed above: (https://console.cloud.google.com/storage/browser/broad-public-datasets/NA12878/unmapped/) is exactly the one which Board transferred from ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR194/ERR194147/ERR194147_1.fastq.gz and ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR194/ERR194147/ERR194147_2.fastq.gz. via the same way as u said.
m gvcf -> go through joint-calling -> 1VCF and index.
Looking at this workspcae dataset on firecloud, only 1 sample NA12878, how could it generate multiple gvcf for joint calling?
For benchmarking, i am looking for NA12878, 12891, 12892 data to went through the whole Germline-SNPs-Indels pipeline. since the wdl perfer ubam files as inputs, I would like to have 3 list of ubams.
I was able to find another resource that might help you with your analysis. This link shows how to separate your input BAM/SAM/CRAM by RG by using the -RG (--splitReadGroup). Once you have converted your sample fastq files to the uBAM with FastqtoSam, you can split it up by RG to generate the list of uBAMs!
The data that you see in the bucket (https://console.cloud.google.com/storage/browser/broad-public-datasets/NA12878/unmapped) is generated by the Broad - the data in the bucket are read group uBAMs that belong to the test sample NA12878.
For the joint discovery workflow, if you look at the method configuration, you will see that the input is a participant set entity type. This means that there are multiple participants which means multiple gvcfs that go through joint calling to get a single vcf.
I don't believe that we have any benchmarking data. We use NA12878 in the featured workflows as you have seen already.
I hope this information helps! Please let me know if you have other follow-up questions.
@SChaluvadi , Thanks for your answer and help! I also found the Board offered wdl script to convert fastq/BAM/CRAM to uBAMs.
But I still have a vital problem.
I download fastq1 and fastq2 file from: ENA, https://www.ebi.ac.uk/ena/data/view/SAMEA1573618.
each fastq file from the same lane which owns the same readgroup name.
lane1.fq, lane2.fq, lane3.fq, lane n.fq -----> RG1.ubam, RG2.ubam, RG3.ubam, RGn.ubam.
Seems like I only have 2 merged fastq files which contain multipe lanes data for 1 sample. What shoud I do now?
write script to split fastq file into different smaller fastq file according on different C0D8DACXX: n firstly, then run fastqtosam separately?
Hi @SChaluvadi , I read some other webpage which also from the webpage u mentioned before.
It seems like I can ignore the flowcell:lane information which showed in my fastq files read header, just assign it as what I want, such as default A. for the whole big fastq file.
Do you think this way is right or not? will it cause some problems or reduce its accuracy for the downstream dealing ?
There is one problem before I can use SpliteReads, it asking for BAM/SAM/CRAM.
Now my input is fastq1 and fastq2, when i zless it, it contains multiple lanes information. When I try to use FastqToSam, it asking read groups name and corresponding fastq.
write script to separate merged fastq file based on flowcell:lane infomation on each read header.
use FastqToSam to each fastq file. -> n ubam files.
@Angry_Panda Sorry for the delay! Yes, in your case, where reads from a single sample run on multiple lanes are all in a single fastq file, you must split the fastq file by lane into multiple fastq files. After this step you can use FastqToSam to generate uBAMs (1 uBAM per lane for a single sample). At this point you can add the RGs and later combine your BAM/SAM files using MergeSamFiles.
Here is a link to a one liner that might help you seprate your fastq file by lane. I think these steps should help you achieve your goal. Please let me know if this works for you!
Hi there @Angry_Panda - since we haven't heard from you, this ticket will be closed but you are always able to send us another message if you have any other questions!
Hi @SChaluvadi , sorry for my late relpy.
I was testing the method we talked above. Yes, It worked. Besides, awk, you also can use | grep, to separate the raw fastq files, then use FastqToSam to generate several ubam files based on its flowcell:lane info. I got 4 ubam files, then I continued with the data-processing step, using gatk4 hg38 json and wdl files, originally from: https://github.com/gatk-workflows/gatk4-data-processing.
After two days, with 16 threads, it showed: workflow successfully completed.
I found a little bit funny result: my input 4 ubams, each of them sized 33G, my aligned.duplicates-marked.sorted.bam sized around 120G. After, BQSR, the final output bam file sized around 70 G.
Do you think this is normal or I did something wrong? I use NA12878.


text:
package com.github.prasanthj.hll;

import static org.junit.Assert.assertEquals;

import java.util.Arrays;
import java.util.Collection;
import java.util.HashSet;
import java.util.Random;
import java.util.Set;

import org.junit.Test;
import org.junit.runner.RunWith;
import org.junit.runners.Parameterized;
import org.junit.runners.Parameterized.Parameters;

@RunWith(value = Parameterized.class)
public class TestHyperLogLogDense {

  // 5% tolerance for long range bias and 3% for short range bias
  private float longRangeTolerance = 5.0f;
  private float shortRangeTolerance = 3.0f;

  private int size;

  public TestHyperLogLogDense(int n) {
    this.size = n;
  }

  @Parameters
  public static Collection<Object[]> data() {
    Object[][] data = new Object[][] { { 2 }, { 10 }, { 100 }, { 1000 }, { 10000 }, { 100000 },
        { 1000000 } };
    return Arrays.asList(data);
  }

  @Test
  public void testHLLAdd() {
    Random rand = new Random(size);
    HyperLogLog hll = HyperLogLog.builder().setEncoding(HyperLogLog.EncodingType.DENSE).build();
    int size = 100;
    for (int i = 0; i < size; i++) {
      hll.addLong(rand.nextLong());
    }
    double threshold = size > 40000 ? longRangeTolerance : shortRangeTolerance;
    double delta = threshold * size / 100;
    assertEquals((double) size, (double) hll.count(), delta);
  }

  @Test
  public void testHLLAddHalfDistinct() {
    Random rand = new Random(size);
    HyperLogLog hll = HyperLogLog.builder().setEncoding(HyperLogLog.EncodingType.DENSE).build();
    int unique = size / 2;
    Set<Long> hashset = new HashSet<Long>();
    for (int i = 0; i < size; i++) {
      long val = rand.nextInt(unique);
      hashset.add(val);
      hll.addLong(val);
    }
    double threshold = size > 40000 ? longRangeTolerance : shortRangeTolerance;
    double delta = threshold * hashset.size() / 100;
    assertEquals((double) hashset.size(), (double) hll.count(), delta);
  }

}


Hello. I'm currently experiencing some troubles to get the results I want, so please someone help me.
I created a manager that provides the inputs for two pawns. However no inputs work as intended. iI have three classes (Cam Manager, RTS Camera and Game Pawn). My manager controls in two TArrays the number of cameras and game pawns. What i want is for manager to set the inputs of both the other classes,and for a given pawn to be controlled but it isn't working.
I can't seem to get how to move a pawn towards the mouse direction.. What I want to do is to move my camera pawn towards the direction the mouse is in the viewport. Like this: If I move my mouse to the right edge of the screen/viewport, I want my spectator cam to move in that direction, but I don't understand how to do it.
Please, help. It's for educational purposes and I can't get it to work.


Mechanical adult Pteranodon from Messmore & Damon's attraction "The World a Million Years Ago," which debuted at the Chicago World's Fair (1933-4), "A Century of Progress." Over the years this figure has been revamped and restored a number of times.
How this figure originally looked back in 1933 at Messmore & Damon's studio in New York City.
One of a series (f0r more views, CLICK HERE) of souvenir postcards from Parco Zoo del Garda-Parco del Dinosauri, in Bussolengo-Pastrengo, Italy, showing a life-sized statue of Pteranodon.
Postcard (one of a series) from Dinamation International Corp. showing that company's "updated" full-scale animatronic Pteranodon.


The struggle is real. Everyday, brands face the challenge of how to get attention in an increasingly crowded digital space. With OTT views on the rise (and traditional television views on a steady downward slope), brand advertisers are always on the lookout for the best way to reach their audience at scale.
At Zefr, our product, engineering and data science teams are producing some pretty cool and unique solutions to these challenges. So, we decided to create "Technically Speaking," a video series that takes a deep dive, behind-the-scenes look at our proprietary technology—including stuff that hasn't been released! Call us crazy, but we like to call it "pushing boundaries." After all, our namesake Zephyr skate team, circa 1970's, pioneered the Venice, CA skate culture with their drive for innovation and performance. We aspire to do the same for video advertising.
Our comfort zone is on the cutting edge, where great ideas are born and mature into even better technological solutions, using machine learning and human review. True to our motto, "Go big. Go Fast," we're moving full speed ahead with no plans of slowing down anytime soon. Go on. Take a peek under the hood and see for yourself.


Update. The girl at work called me and she didn't forward my emails to the owners. I guess I have more time to figure out a plan. That place just won't let me go.
The thing is mate you are obviously more valuable than you realise. It might not feel like it but their is a reason she did not forward your Emails.
The ball is always in your court, if you think otherwise then it's a slippery slope involving anxiety/panic.
Everybody's life is only in control of themselves, people can advise, dictate and learn from the mistakes you learnt after taking their advice!
But the bottom line is you want to live a life that is comfortable, to make that happen then you need to do what is best for you, and only you!
Realising you are valuable has already been pointed out by the girl at work, now you just got to see that without drinking as a coping mechanism. I'm not saying don't drink but to only drink when you are up and in control, not drinking when you are low and not in control.


Founded on professionalism and quality, and that's exactly what we hang our hat on. From your first meeting with one of our sales associates until we pack up and pull off your property we will be courteous, punctual, and respectful. With over 20 years experience in all facets of hardwood flooring we pride ourselves in delivering a product to our customers that is nothing short of spectacular. Your satisfaction is more than important, it's imperative. Our state of the art tools and equipment accompanied with our experience guarantees a great looking floor, and we don't just specialize in great floor we're also very conscience and careful with your home. Making sure it's as dustless and odor free as possible is important to us, we treat your home as if it's our own from start to finish. You will love the new look and value your hardwood floors will bring to your home.
Honesty is at the forefront of how this company is run which means whatever promise we make during negotiations will be fulfilled. Our expertise affords us the ability of being able to assess most situations at first sight, and because trust is important, we make sure our assessment is accurate and efficient. We go the extra mile to make sure that your flooring experience with us is one that you will rave to your family and friends about.
We always wanted to remove our carpet and redo our hardwood floors but after several contractors gave us estimates it just seemed like it wasn't going to happen. Elegant Hardwood floors was the last company we interviewed and I must say the salesman was so informative we booked them on the spot. The guys was on time, there work was surprisingly neat and my floors looked awesome. I highly recommend you guys.
I was very apprehensive about allowing a contractor in my home. I've seen and heard it all. I usually google or YouTube a project and do it myself. So after I destroyed my living room floor we called Elegant Hardwood floors. They where very reasonable, my floor looks like it's out of a magazine. GREAT JOB!!!
I just want to say this company is great! My floors had tile and carpet covering them they removed it and sanded,and refinished our whole house. My home looks like a new home. There was no dust and you can eat off my floors. You guys are the best!
Thanks for installing our downstairs and sanding our steps to match. I didn't know how you guys were going to find the color but it's perfect. We will call when we're ready for the upstairs to be done. Good work!


text:
SYNONYM

#### According to
The Catalogue of Life, 3rd January 2011

#### Published in
Stud. Trent. , ser. 2 7: 5 (1926)

#### Original name
Polyporus bosei Bres., 1926

### Remarks
null


text:
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.
As people enter their forties and fifties, muscle mass starts to decline because of aging and, in some cases, decreased activity levels. Muscular atrophy can also occur because of health conditions, such as joint pain. As we age, it's important to increase or maintain muscle mass through strength training, not only because it helps burn calories, but also because muscle mass is essential for strength and balance.
Get in plank position with your hands wider than shoulder-width apart (A). Lower your chest as close to the floor as you can. Holding that position, lift your right knee to the outside of your right elbow (B). Return to plank position, then push back up to start; repeat on the other side. That's one rep. Do three sets of 12 to 15 reps, resting for 30 seconds between sets.
Inflammation (in-fluh-mey-shun): The redness and warmth around a cut or scrape is short-term inflammation, produced by the immune system to aid healing. But another type called chronic inflammation, triggered by compounds from abdominal fat, gum disease and other factors, lingers in the body. Research suggests this type increases the risk for heart disease, diabetes, dementia and some forms of cancer.


text:
Q: Importing test result files on .tap format into sonarqube We are testing SonarQube to see if it's usage would be good for us. Our project has a test suite which outputs test results to .tap files.  Would it be possible to get them integrated into SonarQube so that it shows how many tests were performed and how many failed? Is there some plugin available that I couldn't find or would that require writing my own? Any pointers for where to start looking would be appreciated.

A: If your files are generated using the Test Anything Protocol, I don't think an import plugin exists for SonarQube.
If you wish to roll your own, you can have an overview of what is required on the Plugin Development documentation. The classes from the org.sonar.api.test package will be your entry point for the injection of test related data.
For the report parsing part, you can have a look at the Tap4j library.

A: In the meantime, a SonarQube plugin for TAP has been created:
https://github.com/dbac2002/sonar-tap-parser

redpajama_set_name: RedPajamaStackExchange


text:
Global sight
Climate summit COP26 postponed to 2021
by Martina Pugno · May 06, 2020
The general lockdown due to the dramatic rise of COVID19 has not spared even the COP26 in Glasgow, which has been postponed to 2021.
The Coronavirus emergency has blocked the entire world, drastically slowing down the global rhythm. All those activities – which are considered "non-essential" for human needs have stopped and, inevitably, the same happened for COP26 in Glasgow. The climate conference was planned to take place next November, now rescheduled to 2021.
Following the UN intervention which sanctioned the climate summit's rescheduling came the statements of the European Commission, which announced its willingness to keep its commitments on the global climate agenda despite Covid-19. The summit was supposed to discuss the participating states' commitments in compliance with the Paris Agreement, the greenhouse gas emissions reduction and managing finance, with the aim of fight the climate change. According to the delegated representatives, the postponement of COP26 does not mean any suspension of efforts on achieving climate targets.
Frans Timmermans, Executive Vice-President for the European Green Deal, states: "As for the European Commission, we will not slow down our work domestically or internationally to prepare for an ambitious COP26 when it takes place. At home, we have put in place the key EU laws to meet our existing 2030 climate and energy targets. In the long-term, we have committed to climate neutrality by 2050 and proposed a climate law that will make this objective legally binding. The legislative work on this proposal has started, even in these challenging circumstances".
Among the numerous reactions to the summit's rescheduling, Sergio Costa, Italian Ministry of Environment, confirmed Italy's commitment to the fight against climate change. Associations such as WWF, Greenpeace and Legambiente say they support COP26's postponement and sincerely hope that the time taken forcibly due to the pandemic can at least be supportive of achieving some of the climate summit's goals.
In the meantime, confirming the intention to keep fighting against climate change, the central Executive has launched a cost-benefit analysis, which will be shown in September, to bring the EU targets set for 2030 one step higher: to reduce emissions by 50-55% compared to 1990 figures.
Tags: Global sight
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10 sustainable ideas for 2021
Our future depends on bees too!
DHL GoGreen, for zero-impact sea shipments within 2050


text:
Ruth Davidson
Ruth Davidson to hit out at SNP calls for second independence referendum
The Scottish Conservative leader will challenge Nicola Sturgeon's party to 'put the national interest before its own nationalist vision'.
Scottish Conservative leader Ruth Davidson
SNP calls for a second independence referendum in the wake of the Brexit vote are "utterly unjustified" and "completely irresponsible", the Scottish Tory leader will say.
With the vote to leave the European Union causing political turmoil, Ruth Davidson will challenge Nicola Sturgeon's party to "put the national interest before its own nationalist vision for once".
Nicola Sturgeon campaigning before the Brexit vote
Ms Sturgeon, the SNP leader and First Minister, has already said the European referendum result and Scotland's vote to stay in make another ballot on leaving the UK "highly likely".
Andy Murray wins Wimbledon for second time
First Minister Nicola Sturgeon meeting business leaders over Scottish response to Brexit
Meanwhile the party's Westminster leader Angus Robertson said that a second independence referendum is "exactly what we will do" if Scotland is not permitted to remain in Europe.
Ms Davidson will use a speech to lobby journalists in Westminster to accuse the nationalists of seeking to make gains from the current turbulent times.
She will also insist that memories of the "divisiveness and toxicity" of the 2014 referendum campaign mean that most Scots do not currently support staging another vote on the issue.
Ms Davidson will say: "The SNP is, as usual, trying to seize on a moment of doubt and uncertainty to declare that the shining star of independence is the answer.
"And it's trying to claim that, as a result of Brexit, there is now a massive groundswell for a second independence referendum.
"This is simply not true. Even after the EU vote, only four in 10 people in Scotland say there should be an independence referendum.
"Firstly, that's because we had a vote on this, less than two years ago, when people in Scotland voted quite clearly to stay part of the UK.
"Indeed two million people voted to do so, more than the 1.6 million in Scotland who voted to remain within the EU.
"And it is also because people's memories of the divisiveness and toxicity of that independence referendum campaign are still fresh - and many people don't want to revive them."
In these circumstances "bluster" from senior SNP MPs that a second referendum will now happen is "utterly unjustified and it is completely irresponsible", Ms Davidson will claim.
The Tory MSP will state: "Unjustified because our decision to remain part of the United Kingdom less than two years ago must be respected - as the SNP promised it would do.
"And irresponsible because it only piles uncertainty on top of uncertainty.
"It is time the SNP put the national interest before its own nationalist vision for once.
"You cannot uphold the EU referendum result in Scotland as sacrosanct while trashing the Independence referendum vote we held just 22 months ago.
"And you don't solve the questions around leaving one union by walking out on an even more important one."
An SNP spokesman said: "Ruth Davidson has already conceded that Westminster should not block a second independence referendum.
"The SNP's focus is on the negotiations that lie ahead to protect Scotland's relationship with the European Union and our place in the Single Market. Scotland needs the stability and security of remaining in the world's biggest single market - for jobs, investment and prosperity.
"A second independence referendum is an option which is very much on the table - and even the Scottish Tories now agree that the UK Government cannot stand in the way."


KILLEEN, Texas James Fullbright led the Midway offense Thursday night as the Panthers won at Harker Heights 55-13. The win keeps the Panthers perfect in District 12-6A play this season.
Fullbright scored the first two touchdowns for Midway on a 23-yard run in the first quarter and a 17-yard run in the 2nd quarter. He added another touchdown run early in the third quarter for Midway.
In between his TD runs Nick Jiminez threw a pair of long touchdown passes as Midway put the game out of reach in the first half.


text:
Laura Fitton
Founder of DeskHappy, Pistachio Consulting and oneforty
HistoryPistachio ConsultingTwitter for DummiesOnefortyHubSpot
Documentaries, videos and podcasts
Laura Fitton is a marketing consultant, public speaker, author and advisor. She made her name with @pistachio, her Twitter handle, co-authoring Twitter for Dummies and founding oneforty.com.
Once dubbed the "Queen" of Twitter, Laura Fitton has described her use of Twitter as a love affair. During her time as a marketing consultant, she came across Twitter, tried the platform out and was unsure of it. Then she discovered Twitter such allowed her to surround herself with interesting and successful people. This led to @pistachio, her eponymous Twitter handle, and to convince Guy Kawasaki, in 2007, Twitter was going to be big.
Pistachio Consulting
In 2008, Laura converted on her Twitter success and re-launched Pistachio Consulting. Pistachio consulting described themselves as connecting businesses to new ideas and innovations using the tools to microsharing.
Pistachio consulting was close to failing during 2008's financial crisis. Laura had a single client, Charity: Water, for which she was able to raise $25,000. This was one of the first donate by tweeting campaigns. Her success gained traction, being listed on Huffington Post as one of Arianna Huffington's top five favourite Christmas Day stories of that year.
In turn, Laura turned her expertise and experience on Twitter into co-authoring Twitter for Dummies in 2009 with Michael Gruen and Leslie Poston.
Oneforty
Laura turned to start-up work with oneforty Inc., or oneforty.com, an app store for Twitter which worked to catalog and curate the best extensions and apps for Twitter. The tool included a community of users who shared and rated the tools.
oneforty was able to raise $2.25 million through funding rounds until they were acquired by HubSpot in 2011. Before this acquisition, oneforty pivoted to a business user focus. The site turned into a place for business users to understand social media. They included information on how to invest a budget, what other companies were doing, buyers guides for brands and reviews of social media tools. The acquisition saw oneforty merge into HubSpot's App marketplace.
When oneforty was acquired by HubSpot, Laura Fitton was kept on as HubSpot's Inbound Marketing Evangelist. Her role is described as showing companies how to grow by helping people buy instead of marketing to them.
140 Conf - Twitter, A Love Story
https://www.youtube.com/watch?v=DVc2vpYlogw
Interview with Laura Fitton
https://www.ncwit.org/sites/default/files/audio/laura.fitton_oneforty_4-25-11.mp3
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text:
Q: Use(logic) of : operator C# Can anyone explain what the ":" stands for in code. I understood the code but dont know the logic/condition behind this ":" operator.
public Constructor() : this("No names", string.Empty)
{
}

A: In your case, you have a class with multiple constructors, so
the
class Constructor()
has a default(no args) constructor and a constructor wit 2 strings as argument.
If some one calls the default constructor, then the class will internally call the constructor with 2 strings overloading it.
that is the explanation of that code


text:
<!DOCTYPE html>

  <meta charset="utf-8">
  <title>Date parser test — 3.With brackets and with space before and after the string — September 24 (comments), 1978 3:00:00 AM +0200</title>

Failed (Script did not run)


It is fair to note, however, that because of his great wealth, he was able to personally finance almost totally his self-promotional campaign for the party's nomination. His total lack of respect for those also seeking the nomination will long be recorded as dark history in the annals of Republican presidential campaigns.
Trump, despite reported valiant efforts by his various campaign managers to remake his public image, remains the same person he was before becoming our president. There remains the legitimate question of how much of his recently modified external persona comes from an internal rebirth of personal and emotional character traits and how much is a scripted cover-up.
It is appropriate to note that Trump has tapped a deep reservoir of anger and fear within many Americans who understandably feel betrayed by both parties. It is fair to point out that those on the left neglected our broader citizenry as well.
For example, nearly 60 percent of our population was systematically ignored within our educational system when career and technical education became second fiddle to the notion that only college was a worthy goal. Many were sold a bill of goods that if they worked hard, took care of their families and served their communities, they would experience economic and social stability.
Little did they know those at the top would focus on a financial bottom line and grow rich at the expense of the dreams of conventional American citizens.
Their misdirected focus was on those at the bottom, who could have found a rung on the ladder had not the economic game board become so distorted by greed and single interests. These same political liberals made their own situation worse as they focused on expensive, dependency-creating programs offered in silos trapping many families at the survival level. The ultimate bottom line is that winning is losing when solutions are unbalanced.
Those who yearn for the restoration of dignity, knowledge and respect into the political arena need to step forward to accept appropriate full responsibility for the nomination and election of our president. Let us hope Americans of both political ideologies learn from their recent actions.
Let us pray they will reach out to each other and rise above demeaning political conduct. Despite their philosophical differences, may they pledge to work together to once again create balanced governmental policies administered by esteemed leaders serving all Americans and preserving our nation's dignity as a world leader within the global community.


text:
Home › Walker Books Build a Robot
Walker Books Build a Robot
Build a Robot provides a unique interactive guide to robots in their many guises, and includes everything you need to build a trio of performing robots.
Robots work for and with us in hundreds of ways, from performing repetitive tasks to exploring the galaxy. Discover how they interact with us on every level - then build three different wind-up models of your own and set them whirring into life!
* Building each of your three robots gives you a unique, hands-on understanding of the basic engineering involved. The pre-cut pieces are clearly labelled to help you assemble the model. Simply follow the step-by-step instructions and slot together the pieces.
* Clear illustrations and accessible text explain how simple machines have developed into the robots that now function all around us.
* RoboTech Factbursts in every section look at a different aspects of robot engineering/ technology/mechanics on each spread.
Steve Parker graduated with a BSc (Honours, First Class) in Zoology and is a Senior Scientific Fellow of the Zoological Society of London. He has written more than 200 books and has edited or contributed to over 100 more.
About the illustrator:
Owen Davey is a freelance illustrator, living and working out of Leicester, United Kingdom. His work has been published in every continent except Antarctica.
* Imprint: Walker Books Australia
* Author: Steve Parker
* Illustrator: Owen Davey
* Pages: 32
* Release Date: 1 November 2014
Book Size: approx. 36.8cm x 19.2cm
Age Group 8-12 Yrs, School Age 5-8 Yrs
Gender Boy


How To Install An Expanding Foam Fence Post | Home Guides | SF .
Expanding foam is a lightweight, waterproof alternative to concrete for homeowners wanting to set fence posts. The foam can be used in hot or cold weather and does not . Ensure it is upright, and brace the post into position using one or two small pieces of wood. Nail the brace in place, but only drive the nail in enough to..
Secure Set - 20 Post Kit. Fast, Secure & Safe Concrete Alternative .
Installing fence posts is not a difficult task, but there are some basic things to keep in mind. This is true whether one is installing a mile of farm fencing, or a couple of hundred of feet of fence for a backyard. One of the most common mistakes occurs when ground expansion caused by frost and/or moisture is not taken into..
Anyone use concrete posts for pasture/perimeter fencing? Pros, cons, thoughts? I know concrete isn't very environmentally friendly, but neither is dipping wood in used motor oil and then putting it in the ground! I'm lazy (I'll be the first to admit it!) and I only want to do this once, so concrete seems like a really..
Fast 2K 26 oz. Fence Post Backfill(254-20-S) - Concrete / Blacktop .
2-lbs Fence Post Backfill. Convenient alternative to concrete to set fence posts; 1 x 2-lbs bag replaces 2 x 50-lbs bags of concrete; Sets posts in minutes; No water required; Mixes in just 30 seconds; Expands to fill the post hole; Ideal for all types of posts; Can be used during winter; Same technology used to set utility poles..
Sep 26, 2017 . You first must choose the post style, align a perimeter for your fence, dig the holes, and then slowly pack dirt in and refill the post hole while keeping it level. So why not eliminate one of those steps and use a product that doesn't erode away like dirt? When it comes time to refill the fence post hole with dirt,..
How NOT to Anchor a Fence Post - Expanding Foam Fence Post Mix .
Apr 14, 2017 . When Dad knocked over the fence with a backhoe, I tried a new fence post mix product that expands as it dries. . In years past, I've used a bag of quick-dry concrete to set posts, so the plan was to buy a new 4×4, set it, reattach the hardware, and done (you actually don't even need to separately mix the..
This expanding foam will save you from hours of laboring over .
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Caps Vinyl accessory placed on top of fence posts to provide a finished look and prevent water penetration. Chalking White residue visible on the surface of a vinyl fence as it weathers. Crimp lock Method for fastening rails inside posts. The rail is notched. (crimped) so that it stays within the post once inserted. Expansion..
I decided to use expanding foam instead of concrete to install a new .
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I can't tell you how many potential clients have no PR/marketing budgets or strongly believe that spending $$$ on professional PR/marketing is expensive; a cost rather than investment for their business. Well, let's just see. Here is some shocking facts for all those non-believers.
A list of 12 comparisons among common consumer products and services.
Facebook Page = what is cheaper than free?
Website = cheaper than the average of 3 car payments.
Business Marketing plan = cheaper than a lightweight road bike.
News release about your business = cheaper than a pair of running shoes.
YouTube business video = cheaper than a canister vacuum.
Banner = cheaper than 2 pairs of your favorite wedge or slip-on Croc shoes.
Business Logo = cheaper than two hours with your plumber.
Social Media = cheaper than any form of advertising today. Reach over 1,000 people for less than $1.
Musical jingle = cheaper than a bachelor party weekend.
Radio personality at your event = cheaper than upgrading to a new smart phone.
200,000 new encounters in 20 minutes = cheaper than a oil change.
Marketing consultant = cheaper than a divorce lawyer!
We understand your marketing program is a balancing act. So, why not take control with smart, cost-efficient business building marketing strategies?
Call or come in for a free one-on-one consult from a PR/marketing professional.


Give definitions for the common terminology used in horticulture to enhance communications and understanding about plants.
Describe the system of taxonomy and classification.
Practice diagnostic skills of judiciously examining plants and plant parts for plant identification.
Practice diagnostic skills of judiciously examining plants and plant parts and correlating observations with print information in the diagnostic process.
Explain examples of how plant structures and growth processes correlate with common plant disorders.


text:
Q: SQL получить строки без русских букв Хочу получить все строки без русских букв в определенном поле. Делаю запрос:
SELECT * FROM `dle_post` WHERE `full_story` not like '%[а-я]%'

Выводит все строки - как с русскими буквами, так и без них.
В чем моя ошибка? Как вывести все строки без русских букв?
Попробовал без диапазона или набора, например %а%- работает. Какие проблемы могут быть с диапазоном/набором?
Примеры везде с символами []%_^ - Оператор SQL LIKE. Может, есть альтернативное решение - без регулярок? Или [а-я]% - это последовательность, а %[а-я]% - уже регулярка, так как алгоритму нужно несколько раз проходить по строке, чтобы найти совпадения?


text:
Ice Castles return to Lake Geneva this winter
The Ice Castles will return to Lake Geneva for the fourth year and the third season at Destination Geneva National resort, organizers announced Thursday.
By Bobby Tanzilo Senior Editor/Writer Published Oct 21, 2021 at 10:31 AM
This year, they say, the castles will be bigger, with a "more immersive" design and will also offer sleigh rides.
The giant man-made ice formations include towers and caverns and integrate slides, crawlspaces, tunnels and fountains.
The specific opening date is weather dependent but they have typically been ready by the second half of January and usually remain viable through the end of February.
Ice Castles first appeared in Lake Geneva in 2019. They moved from the lakeside beach to the current location the following year. This year there are similar castles in Utah, Minnesota, New Hampshire and New York.
Work growing icicles to build the castles can begin as early as November and a team of upwards of 20 ice sculptors works for anywhere from eight to 12 weeks bringing them to life.
"We are excited to bring the magic of Ice Castles back to Wisconsin this winter with an expanded experience," said Ice Castles' CEO Kyle Standifird.
"Our mission is to give people a place where they can escape from the hustle of daily life for a moment and step into a frozen fairy-tale world while creating a fun and safe outdoor experience."
Tickets to will go on sale in December at icecastles.com.
Ice Castles, Lake Geneva, Destination Geneva National, winter fun
Bobby Tanzilo Senior Editor/Writer @BobbyOnMKEcom
Born in Brooklyn, N.Y., where he lived until he was 17, Bobby received his BA-Mass Communications from UWM in 1989 and has lived in Walker's Point, Bay View, Enderis Park, South Milwaukee and on the East Side.
He has published three non-fiction books in Italy – including one about an event in Milwaukee history, which was published in the U.S. in autumn 2010. Four more books, all about Milwaukee, have been published by The History Press.
With his most recent band, The Yell Leaders, Bobby released four LPs and had a songs featured in episodes of TV's "Party of Five" and "Dawson's Creek," and films in Japan, South America and the U.S. The Yell Leaders were named the best unsigned band in their region by VH-1 as part of its Rock Across America 1998 Tour. Most recently, the band contributed tracks to a UK vinyl/CD tribute to the Redskins and collaborated on a track with Italian novelist Enrico Remmert.
He's produced three installments of the "OMCD" series of local music compilations for OnMilwaukee.com and in 2007 produced a CD of Italian music and poetry.
In 2005, he was awarded the City of Asti's (Italy) Journalism Prize for his work focusing on that area. He has also won awards from the Milwaukee Press Club.
He can be heard weekly on 88Nine Radio Milwaukee talking about his "Urban Spelunking" series of stories.
New Geneva Tap House has 50 taps that let you serve yourself
Bobby Tanzilo Jun 16 Bars & Clubs
Lake Geneva Ice Castles opening this week
Bobby Tanzilo Jan 18 Travel & Visitors Guide
Lake Geneva Ice Castles open Friday
Bobby Tanzilo Jan 18, 2021 Travel & Visitors Guide
What's familiar is sparkly new again in Lake Geneva
Bobby Tanzilo Sep 12, 2019 Travel & Visitors Guide


If you were impressed with last year's Pixels, prepare to be blown away by this year's Pixel 2 and Pixel 2 XL.
The new flagship handsets build on everything that was great about the original Pixels and then some. After a few short demos following Google's event today, it's already clear the Pixel 2 and Pixel 2 XL are more than capable of competing with the best Android phones and, yes, the iPhone 8.
Both HTC-made handsets have a similar design to their predecessors, with a few notable exceptions. First, neither has a headphone jack, which was maybe inevitable but is still somewhat of a bummer. Both phones also have noticeably smaller bezels than the first generation Pixel and Pixel XL.
The original Pixel had a significant bottom bezel that always felt a little bit like wasted space. The latest phones, though, have trimmed down a lot of that extra space, which makes the phones feel more compact even though they've maintained the same display size as last year's models.
The back of the phones are largely unchanged with nearly identical placement for the fingerprint sensor (still in the middle of the back side) and the rear-facing camera, which has moved slightly but is still exactly where you'd expect.
Google has, however, changed up its color schemes this year. The Pixel 2 is now available in a "Kinda Blue" color in addition to the standard black and white versions. The Pixel 2 XL comes in a (rather aptly named) "Just Black" color as well as a "Black and White" model.
One of the biggest rumors leading up to today's launch was that Google would be adding a new hardware-based gesture for Google Assistant with a new "squeezable frame." Similar to HTC's U11, the Pixel 2 and Pixel 2 XL have built-in sensors to enable this gesture, which calls up the Assistant.
I was initially worried that the sides could be too sensitive, so that sliding your phone into your pocket could accidentally trigger the assistant. But in practice, the gesture actually requires a surprising amount of pressure. It's still definitely possible to trigger it by accident, but it doesn't seem like it will happen as often as I had thought.
Of course, the idea of "squeezing" your phone may seem a bit odd, but it really doesn't feel any less natural than pushing a button or swiping on your screen. And I much prefer it to Samsung's infuriating Bixby button, which I constantly press by accident.
The camera was one of the most hyped features on the original Pixels, so it's no surprise that Google dedicated significant time in today's launch event to discuss the many, many new camera features in the Pixel 2.
The crowded demo rooms of launch events are pretty far from the ideal place to test a camera, so we'll have to wait for our full review to really put the cameras to the test, but I walked away impressed from my first look.
For starters, Google has added a new portrait mode to the Pixel 2 camera. While Apple and other manufacturers rely on dual camera to achieve the depth effect, Google instead used software to achieve it. This is also why portrait mode works on the selfie camera, as well as the rear shooter.
The company also added its own version of Apple's Live Photos with a feature it calls "motion photos."
Again, I wasn't able to fully test these features, but my first impression was that they're easily as good as what I have on my iPhone 7 Plus.


Brandissima Inc. was incorporated on 2014-07-11. This company is now Active.
Their business is recorded as Non-distributing corporation with 50 or fewer shareholders. As so far this company has running for 4 year(s) 287 days.
2014-07-11 to Present Brandissima Inc.
COURTIER EN CAMIONNAGE BRANIFF INC.
Brandreth's Flowers and Gifts Inc.
BRANDBOURG MARKETING & DESIGN INC.
Branch Like A Tree Investments Inc.
LIGNES DE BRANCHE (1981) INC.


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text:
TVR Tuscan Cup v0.9
TVR Tuscan Cup for GTR2
Mod created by scca1981
Mod Infos :
This is a semi-fictional cup based on the 1995 TVR Tuscan Challenge.
Skins – Fictional
Phsyics – Semi Fictional
Real data was hard to find on this car. In the end I was only able to locate such things as weight, engine data, ruff gearbox data, top speed and 0-100 times. So for this reason it gets the "semi fictional" rating. The Engine is based on the 1995 AJP 450 BHP 4.5L V8. The low weight of the car makes it extrememly quick and prone to wheel spin. Drive with care.
The cockpit is small and the top drivers side roll cage will clip some here and there. Best used with DX9.
Championship Infos from Wiki :
The TVR Tuscan Challenge is a one-make series dedicated to the second incarnation of the TVR Tuscan sports car (Initially developed as a road car and then built for the race series), and takes place throughout the United Kingdom. Inaugurated in 1989, its high power-to-weight ratio, capability of reaching 190 mph (310 km/h) and loud engine noise, combined with close racing in a field consisting of over 30 cars at its peak, made the series become, at the time, the premier one-make series in the UK with an extensive TV coverage; over the years, many drivers who competed in the series moved on in major championship series and many notable drivers have guest driven in a race. The company underwent management changes in 2005, and the TVR Tuscan Challenge was merged with its owner club's series, which has been reformatted to allow for all TVR models.
This version of the Tuscan is not to be confused with either the earlier V8/6 model or the later roadgoing Speed Six version.
Drop the Gamedata folder included into your main GTR2 directory and allow any overwrite
When I can locate more solid data a version 1.0 may be released.
For the time being this will remain in beta 0.9 form.
Cars, GTR2Cup, Sports Car
TVR F1 2006 Challenge v1.1
Ultima Can-Am Mod v0.5 beta


text:
Q: Module compiled with Swift 5.1 cannot be imported by the Swift 5.1.2 compiler (couchbaselite) xcode 11.2 I am using couchbaselite enterprise in my project.
After I upgraded XCODE from 10.3 to 11.2, I got this error message. (Module compiled with Swift 5.1 cannot be imported by the Swift 5.1.2 compiler)
my podfile is like this:
# Uncomment the next line to define a global platform for your project
# platform :ios, '11'

target 'Imece' do
  # Comment the next line if you're not using Swift and don't want to use dynamic frameworks
  use_frameworks!

  pod 'SwiftyJSON', '~> 4.2'
  pod 'FSCalendar', '~> 2.7.9'
  pod 'CouchbaseLite-Swift-Enterprise', '~> 2.6.1'
  pod 'Alamofire'
end

I tried below solution bu it did not make any difference.
in XCODE change
BUILD_LIBRARY_FOR_DISTRIBUTION = YES;

Module compiled with Swift 5.1 cannot be imported by the Swift 5.1.2 compiler
I also tried build the (couchbaselite) framework files as mentioned here https://github.com/couchbase/couchbase-lite-ios#how-to-build-the-framework-files
But I got BUILD_FAILED error.
Is there any other solution to get rid of this situation?

A: The error means that Couchbaselite framework needs to be built with Xcode 11.2. You cannot change the settings in your app in order to fix it. So your options are to either

*

*Waiting for release of Couchbase Lite that will support Xcode 11.2 or

*Downgrade your Xcode version to Xcode 11.1 (the version compatible with Couchbase Lite 2.6.1). You can download previous version of Xcode from here


text:
The Insiders est une ancienne équipe de catch à la World Championship Wrestling, composée de Kevin Nash et Diamond Dallas Page. Ils ont été deux fois Champions du Monde par équipe de la WCW.

Historique

Vegas Connection (1992)
Diamond Dallas Page crée en 1991, au sein de la WCW, un clan nommé "The Diamond Mine", auquel se joignent des catcheurs qui deviendront par la suite très populaires sous d'autres noms : Scotty Flamingo (Raven), Diamond Studd (Scott Hall) et Vinnie Vegas (Kevin Nash). L'année suivante, après le départ de Flamingo et Diamond Studd, DDP et Vegas se mettent en équipe sous le nom de "Vegas Connection".
L'équipe se voit séparée au bout de cinq mois seulement, lorsque Page se blesse dans un match opposant la Vegas Connection à Tex Slazenger et Shanghai Pierce. À la suite de sa blessure, il se fait renvoyer de la WCW et n'y effectuera son retour qu'en 1994, tandis que Nash quitte la fédération en 1993 pour rejoindre la World Wrestling Federation sous le nom de Diesel.

The Insiders (2000-2001)

En 2000, alors que Kevin Nash a entamé une feud contre les Natural Born Thrillers, Diamond Dallas Page effectue son retour au sein de la WCW après plusieurs mois loin des rings pour cause de tournages. Nash et Page se mettent alors à nouveau en équipe, sous le nom « The Insiders » (clin d'œil en référence à l'équipe "The Outsiders" constituée de Kevin Nash et Scott Hall). Ils gagnent le titre de Champions du Monde par équipe contre The Perfect Event (Shawn Stasiak et Chuck Palumbo) le  à WCW Mayhem puis le  à Starrcade, après que les ceintures leur aient été retirées par Mike Sanders. Ils perdent leurs ceintures en  à WCW Sin, puis l'équipe se sépare en février.

Caractéristiques

 Thèmes musicaux
  (2000–2001)

Palmarès

 World Championship Wrestling
 2 fois Champions du Monde par équipe de la WCW

Notes et références

Liens externes
  Profil de Kevin Nash sur le site de la TNA
  Diamond Dallas Page Site officiel

Clan ou équipe de catch (WCW)