At least, the kind that I get nowadays. Although my baby girl did just have her 5th birthday! So, as part of her gift this year, I had a pretty, pink quilt done for her and it arrived on our doorsteps today!
Sorry for the poor lighting, it was raining outside and overcast. Once I have a nice sunny day and I get the binding on, I'll take some really great pictures outside.
Linh, with LiMa Sews, did a beautiful job (AGAIN!) on this quilt. She did some feather quilting down the long columns and stippling around the flowers. I haven't had a chance to really inspect it yet, because I was trying to keep Nora from seeing it. Want to surprise her with it at her birthday party this weekend!
On other projects… I have machine stitched the binding to the front of my Swoon quilt. Now I just have to either machine stitch it from the back, or get started with the hand binding. It is a real pain to maneuver around a king size quilt on a small machine in a corner of a bedroom. I may try to move my machine to the dining table and see if it goes easier that way.
I sent my Rally quilt off for quilting as well, and it is already on its way back to me! I have to get it bound and delivered by the end of next week to that new HS graduate leaving for California.
Finally, I have my two blocks cut out for the August month of the current FQS DM BOM 2013 series. Another beautiful basket block that I can't wait to share. Absolutely no problem getting my two blocks of pieces cut from the one set of fabric this month. Lots left over too! Thanks FQS!
Hope all is well with you, lovely reader. I have been super busy with the beginning of exciting school years for my children (Kindergarten and 1st grade!). We are now going to two schools for the first time, which hasn't been too bad. It's kind of interesting to see how it is shaping the kids relationship to be more apart and independent.
← The longest Pep Rally ever!!
Jennifer, Nora's birthday quilt is darling! The quilting sets off the blocks beautifully. Do you not like finishing binding by hand?
Thank you for the compliment Dawn! I actually do like to hand stitch the binding down, once I have attached it by machine. I was just trying to find a shortcut to getting all of my projects finished fast at the moment. Turns out I just worked on it a little each night and I should be done with it tonight for sure. She's waited over 3 months for this gift, so one more day shouldn't hurt. She doesn't know she's getting it anyway.
Your quilt tops are gorgeous! We have the same taste in fabrics, so I will naturally think so! The quilt for your daughters birthday is beautiful. So soft and pretty. I can't wait to see your swoon all finished too.
Thanks Sarah! I hope to get into my Honeysweet fabric soon too!


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Ed Silk Byron Bay is renowned for its collection of the region's most sought-after properties and authentic client-focused service. Over 50% of our business comes from referrals due to our strong and successful history within the Byron Bay region.
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Amazon Prime Gets Black Friday Price Cut...in the U.K.
Through Nov. 18, sign up for one-day delivery, a streaming library, and other perks for a £20 discount.
U.K. shoppers have less than three days to sign up for a discounted Amazon Prime membership.
From now until Nov. 18, the online retailer is offering one-day delivery, a streaming library, and other perks to new users for only £59. Need more incentive? New and existing users with a Prime membership (usually £79) this month will gain early access to Amazon's Black Friday Week deals.
"Amazon Prime is the best deal in the history of shopping and for four days, customers can get an annual membership at a great discount—just in time for Christmas," Christopher North, managing director of Amazon.co.uk, boasted.
Prime sign-ups typically increase in the months leading up to the holiday season, whether customers are planning ahead or need last-minute gifts to arrive quickly. Plus, a membership includes access to popular movies and TV shows, helping to keep the family entertained during cold, wintery nights.
"This year, members will also be able to stream great Christmas music and get 30-minute early access to Lightning Deals, including during Black Friday Deals Week when there will be more deals than ever," North said.
Plus, folks in eligible postcodes in London and Birmingham can take advantage of one-hour delivery on more than 10,000 products via the Prime Now mobile app. Prime members in Greater London, and parts of Hertfordshire and Berkshire, receive free same-day delivery on one million products.
Similarly, Amazon in September offered a limited-time one-year Prime membership to U.S. residents for $67—$32 off the normal asking price. The sale was launched in celebration of the five Emmys won by Transparent—an original comedy series exclusive to Amazon.


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I am an author, poet, diversity & inclusion leader, entrepreneur, and speaker empowering you to do life on purpose.
About: Welcome
THOUGH YOU
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Monique "Nikki" Murphy wrote Home for Hurricanes: A Memoir of Resilience in Poetry and Prose to inspire others, especially other Black women, who have faced similar struggles to know that they are not alone, to find their footing, and to know that there is hope after hurricanes. Her desire is that through her story, readers feel seen and inspired to face life's obstacles with faith and a renewed perspective that uses even the worst experiences as fuel to flourish.
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I have tried checking boxes and I've come to tell you that I have found much more satisfaction in breaking them.
Monique Y. Murphy
About: Quote
Monique "Nikki" Murphy is an awarded Diversity, Equity & Inclusion Leader, speaker, poet, financial literacy advocate, mother, wife, and award-winning author of Home For Hurricanes: A Memoir of Resilience in Poetry and Prose. Murphy has a deep passion and expertise for equipping people, especially in underserved communities, with the knowledge and inspiration to reach their fullest potential in spite of life's obstacles. Her writing, speaking, and teaching aims to provide the encouragement and expertise to intentionally tackle issues that impede progress toward belonging, inclusion, and personal fulfillment.
Murphy has over a decade of experience working with Wall Street firms to enhance their risk and diversity, equity & inclusion (DEI) strategies. She has developed and executed DEI strategies to support the hiring, retention, and advancement of underrepresented employees at Fortune 100 companies and designed dynamic educational programs to raise DEI awareness.
In 2020, Murphy published her debut book, Home For Hurricanes, a coming-of-age memoir in verse that honors the resilience of the human spirit as it explores issues of race, gender, sexual assault, parental abandonment, mental health, and faith. Home For Hurricanes was named a 2021 Best Book Awards Winner by American book Fest and became an Amazon bestseller.
Murphy is the founder and CEO of Literare Living LLC and co-owner of a real estate investment company she runs alongside her husband. They invest in underserved communities and rehabilitate properties to provide beautiful, affordable housing to low-income families.
Murphy has been named a 2019 Diversity Leader by Profiles for Diversity Journal, one of Face2Face Africa's 30 Black Stars Business and Professional Achievers, and has been awarded a Certificate of Congressional Recognition. She has been a featured speaker at numerous conferences and events, on topics ranging from diversity, equity & inclusion to self-empowerment. Murphy holds a B.S. in Finance from New York University's Stern School of Business. She and her husband live on Long Island, New York with their 6-year-old son.
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You might require money urgently and perhaps the thought could have crossed your mind that you can sell your car at a profit and overcome the financial shortfall. But it might also be prudent to shelve any plans for sale of the car and instead concentrate on raising money in other ways – like the cash loan for title, to quote one example.
When a cash emergency hits you it often comes without warning bells and you will be short of cash required to meet the new demands. Sometimes it is am medical emergency that has recently strained your finances, or it could be junior's college fees that stretched your tiny budget. Whatever the need it will create its own deadlines and will brook no delay. This is where pawn car title loans come to your rescue.
Consider the disadvantages of selling your car –you won't get the right price immediately and nine on ten you stand to lose a lot if it's a distress sale. Then the better option would be to ascertain the current resale price of the car – use a reputed forum like the Kelley Blue Book, and approach your nearest title lender for an auto collateral loan based on the collateral of the very same car.
When it comes to auto equity loans the title lender invariably approves over 60% of the present commercial value of the car, and that could aggregate to a pretty large amount, enough to tide over many a catastrophe at short notice. The plus point of a title loan is that you won't have to sacrifice the car, it remains with you for the remainder of your loan repayment program, and that means you get to use it for your personal needs.
It's also easier to apply a car equity loan from the comfort of your home. Just enter basic particulars and the details of your car – its mileage, year, make and model and get an instant quote telling you what you can expect as a loan for vehicle title. This is a far cry from bank loans that kept you guessing whether you are eligible or ineligible for weeks on end while your emergency simmered on the back burner.
Cash title loans base the loan amount on the extent of resale value that your car commands. They have it pretty well figured out – the loan will usually be a percentage of the price that your car commands in today's market. If you feel the need to get a second opinion you can just as easily search the Kelly Blue Book for used car estimates. In any case all that a title lender would ask you to do is to drive your car down to any of his nearest retail outlets where they have seasoned pros valuating your car within minutes. And, by the time you've enjoyed a hot coffee, you will probably have the cash in your pocket.
The drastic reduction in paperwork and loan formalities has made the pink slip loan very consumer friendly. As we have already mentioned, you can ascertain your eligibility online, and then check the resale value of the car at the nearest retail showroom. Thereafter, it is all a matter of submitting your basic papers to get the cash under fifteen minutes – that's the title lender's promise.
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Dr Higgins took up the appointment on 1 December, after carrying out the role on an interim basis since the former Medical Director, Alistair Flowerdew, left the organisation. Dr Higgins was officially welcomed to the Board at his first Board meeting yesterday (Thursday 13 December 2012).
Speaking after his appointment, Mike said: "Having come through the organisation as a working clinician, I feel well equipped to take on this role and I'm really looking forward to continuing the Golden Jubilee's good work. I am keen to help enhance and develop the already excellent services to ensure we continue to provide the best possible care for all our patients.
Mike began his medical career over 30 years ago and has predominantly worked in Anaesthesia and Cardiothoracic Intensive Care within the NHS. He joined the Golden Jubilee in 2008 as Consultant Cardiac Anaesthetist and went on to become the Clinical Director of Intensive Care and Associate Medical Director (Surgical Specialties).


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Example 39.6 Multivariate Analysis of Variance SAS Support
Multivariate ANOVA (MANOVA) Basicmedical Key. Permutational Multivariate Analysis of Variance Using Distance it is directly analogous to MANOVA (multivariate analysis of variance). See example below. For example , we may conduct a A multivariate analysis of variance (MANOVA) could be used to test this hypothesis. Introduction to multivariate analysis..
manova— Multivariate analysis of variance and covariance 3 One-way MANOVA A one-way MANOVA is obtained by specifying the dependent variables followed by an equal sign, MULTIVARIATE TECHNIQUES: AN OVERVIEW USING Multivariate analysis of variance (MANOVA), Discriminant Analysis, Multivariate Techniques: An Overview Example 1:
MANOVA & MANCOVA. 1. Introduction. The term MANOVA comes from Multiple ANalysis Of Variance, and refers to a well established technique for comparing multivariate Introduction and Assumptions for MANOVAPractical ExampleMANOVA in R One-Way Multivariate Analysis of Variance: MANOVA Dr. J. Kyle Roberts Southern Methodist University
Now we will consider the multivariate analog, the Multivariate Analysis of Variance, often abbreviated as MANOVA. Suppose that we have data on p variables which we This MATLAB function performs a one-way Multivariate Analysis of Variance (MANOVA) for comparing the multivariate means of the columns of X, grouped by group.
Now we will consider the multivariate analog, the Multivariate Analysis of Variance, often abbreviated as MANOVA. Suppose that we have data on p variables which we In statistics, multivariate analysis of variance (MANOVA) is a procedure for comparing multivariate sample means. As a multivariate procedure,
Understanding MANOVA. Which multivariate tests are included in MANOVA? What is MANOVA (multivariate analysis of variance)? For example, you are studying the Learn ANOVA, ANCOVA, MANOVA, Multiple See R and Analysis of Variance. using a multivariate analysis of variance (MANOVA). In the following example,
What is MANCOVA? Simple definition of the multivariate analysis of covariance test. How it compares to other tests like ANOVA. Stats made simple! A MANOVA is a statistical test; it is the same as an ANOVA test but with multiple dependent variables. MANOVA stands for multivariate analysis of variance. It tests
26/08/2013В В· An ANOVA and MANOVA Overview Tutorial Mod-01 Lec-16 Multivariate Analysis of Variance (MANOVA) - Duration: 59:27. nptelhrd 10,928 views. 59:27. Multivariate Analyses. Multivariate analysis deals with the An example for the use of CART analysis may be the Multivariate analysis of variance
Understanding MANOVA. Which multivariate tests are included in MANOVA? What is MANOVA (multivariate analysis of variance)? For example, you are studying the Step-by-step instructions on how to perform a two-way MANOVA in SPSS Statistics multivariate analysis of variance example, you could use a two-way MANOVA
MANOVA & MANCOVA. 1. Introduction. The term MANOVA comes from Multiple ANalysis Of Variance, and refers to a well established technique for comparing multivariate A BRIEF INTRODUCTION TO MULTIVARIATE ANALYSIS OF VARIANCE (MANOVA) Like the analysis of variance (ANOVA), the multivariate analysis of variance (MANOVA) has
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The Mayan archeological site of San Gervasio has an unusually long history, beginning sometime around 100 BC and continuing as late as the 16th century. Located on Cozumel Island, the largest island in the Mexican Caribbean, it was still a functioning religious site at the time the Spaniards arrived in the 16th century.
In the heart of the island, in a lush jungle populated with brilliantly colored iguanas and lush flowers and foliage, one can see why no one ever wanted to abandon this beautiful place.San Gervasio was a site dedicated to the Mayan goddess Ixchel ("She of the Rainbows"), deity of midwifery, fertility, medicine and weaving. Many women from the mainland Mayan settlements made the pilgrimage here to Ixchel´s shrine at some point in their lifetime. A graceful arch protects an altar on a sacbe (ancient road) leading into the ceremonial center. Many statues to Ixchel were found here and are still being discovered at the 40+ temples on the island. It is believed that a large ceramic image of Ixchel delivered oracles spoken by a hidden priestess for pilgrims with questions.
Although the archaeological site at San Gervasio has not had a lot of restoration, there are numerous structures and the beautiful natural setting makes a visit there worthwhile. One of the most interesting buildings is the Temple of the Hands. Inside, numerous small red hand prints of unknown significance are painted on the wall, leading more than one tourist to speculate that perhaps this was a day-care center for pilgrim moms!The Mayan ruins at San Gervasio are a welcome retreat for those visiting the busy island of Cozumel. Take time to enjoy San Gervasio and the peaceful setting of this fertile jungle shrine dedicated to the Maya goddess Ixchel.


In this collaborative workshop in London with TEDD Partner Kugelmeiers we will show how to to do histological assessment of 3D spheroids like never before.
Certain standard procedures are indispensable for life sciences. Histology is one of them. Now, with 3D spheroids, a model to closely mimic human physiology for a vast array of applications, is finally broadly available. But for 3D spheroids, histological assessment so far has been done as irregular bulk without a clear optical plane.
Thanks to the totally regular array spheroid building in the Sphericalplate 5D, we will show how to catch spheroids with polymerizing gel and processing histology to a planar array of 750 spheroids. This perfectly fits a microscope slide and allows the user to do histological assessment of 3D spheroids like never before.
If you do histology on 3D spheroids, this workshop is for you. It offers you a new dimension of scalability and analysis flow.
Various research areas like cancer screening and stem cell research need an individual understanding of spheroid biology – cut in one plane x 750 samples gives you unparalleled data accuracy.
Statistical power will be much higher, as you can rely on more, regular data points.
Various showcases like hypoxia effects on spheroid biology or cell population heterogeneity can be studied more accurately when spheroids are organised in one plane.
Patrick Kugelmeier studied medicine and did his medical thesis in islet transplantation for the treatment of Diabetes. The joy of research led to an MD-PhD program for the early differentiation of stem cells. Cell culture technologies at that time didn't allow for good data reproducibility, because stem cells were cultured in 2D. Fueled by the clinical need of small, size-controlled cell clusters to improve islet transplantation and the insights from the sensitivity of stem cells, he began to develop what was later to become the Sphericalplate 5D. After the MD-PhD program, he did his clinical training in visceral and transplant surgery followed by trauma surgery. Besides the clinical work, the Sphericalplate 5D was further developed. Finally, it became clear that this technology opens a new dimension in cell transplantation and regenerative medicine and Dr. Kugelmeier decided to quit surgery to fully live this vision within a startup-company, the Kugelmeiers AG.
Michael Raghunath is a clinical scientist and internationally renowned for work in matrix biology, wound healing, and implementing the biophysical principle of macromolecular crowding in tissue engineering. After completing medical studies in Mainz, Germany, he received training in immunology at the University of Heidelberg, Germany, and as a postdoc in matrix biology and wound healing at the University of Zurich, Switzerland. In 1997, he received his habilitation in Physiological Chemistry and Pathobiochemistry at the University of Münster, Germany, and did a clinical residency in dermatology there. After a stint in industry as R&D director, he became an Associate Professor of Biomedical Engineering and Biochemistry in 2003 at the National University of Singapore. In 2016, he joined ZHAW as Professor and Head, Center of Cell Biology & Tissue Engineering. He currently holds 123 research publications (h-index: 42; 4813 cites) and several review articles and book chapters. He is member of the EU Council for TERMIS and in the editorial board of Current Opinion in Biomedical Engineering, Journal of Tissue Engineering and Regenerative Medicine, and International Journal of Bioprinting. As Director of the Competence Center for Tissue Engineering (TEDD) he has a strong interest in 3D tissue models to replace animal experimentation.


text:
Caesiumthiosulfat (Cs2[S2O3]) ist eine chemische Verbindung des Caesiums und eines Thiosulfatanions.

Gewinnung und Darstellung
Cs2[S2O3]·H2O wird aus einer wässrigen Lösung aus Ba[S2O3] und Cs2[CO3] gewonnen.
 Ba[S2O3](aq) + Cs2[CO3](aq) -> Ba[CO3](s) + Cs2[S2O3](aq)

Das Bariumcarbonat wird abfiltriert und das verbleibende Caesiumthiosulfat wird im Exsikkator über Trockenmittel auskristallisiert.

Eigenschaften
Das wasserfreie Caesiumthiosulfat kristallisiert monoklin in der  mit den Gitterparametern a = 646,94(5), b = 1096,57(8), c = 951,02(7) pm und β = 96,025(3)° und vier Formeleinheiten pro Elementarzelle.
Caesiumthiosulfat kommt auch als Monohydrat (Cs2[S2O3]·H2O) und Dihydrat (Cs2[S2O3]·2H2O) vor.

Einzelnachweise

Caesiumverbindung
Thiosulfat

redpajama_set_name: RedPajamaWikipedia


text:
You Think You Know Metal?
8-Bit Video Game Feat. Metallica, Slayer, Megadeth and Anthrax
Fall of Troy Say They Want a Revolution — So Beware, Metro Station and Brokencyde
For the second time in as many months, a 'cred' band has taken a shot at Metro Station, the band fronted by Miley Cyrus' brother, here on Noisecreep.
When asked by Noisecreep about which cross section of fans the Fall of Troy will appeal to, vocalist/guitarist/keyboardist Thomas Erak said, without a shred of hesitation, "I hope kids can sack up and accept something that is not bulls--t, like Brokencyde or Metro Station, which is all crap rock 'n' roll. Our music is real rock 'n roll. This is real music made by real people playing real instruments."
Ouch! Erak certainly doesn't hide his feelings about what he dubs manufactured rock, and we applaud him for his efforts to keep music as pure and organic as possible. "They could be nice kids, but I am making a statement on what I believe rock 'n' roll is about," Erak said, further explaining, but not defending, his comments. "A lot of s--t out there right now is completely tearing down the ideals about what rock is. If you use auto-tuner or vocoder in rock 'n' roll, you should be shot in the head. Music is the only thing I feel that strongly about."
Erak doesn't stop there, though. He has more to say about what he considers bad music. "Even if a band is nice, I am still on a mission to start a revolution, but I am not going to do that by bringing those bands down one by one. My mission is to have all of them be forgotten. I am not having beef with anyone, but I want that genre to be completely forgotten, you know what I'm talking about? All that mall punk rock crap. I feel the same way about hip-hop right now. I like Lil' Wayne, but whole vocoder thing is out of hand. It's ridiculous. Why sound like that? It dumbs music down and the people who listen to it. That style takes away ability to be creative with their minds."
Fall of Troy's first step in inciting a revolution is their new album, 'In the Unlikely Event.'
Download The Fall of Troy Songs
The Fall of Troy Tour Dates
on TourTracker.com
Filed Under: brokencyde, fall of troy, FallOfTroy, Lil Wayne, LilWayne, Metro Station, MetroStation, miley cyrus, MileyCyrus
Categories: Interviews
2020 Noisecreep is part of the Loudwire Network, Townsquare Media, Inc. All rights reserved.


Major Janitorial Service is a family-owned and -operated business providing exceptional cleaning services in a hassle-free manner. From large complexes to small buildings, we undertake all your commercial cleaning needs. Our professionals are dedicated to maintaining the standard of service you deserve at an affordable price.
Our cleaning services are available at the most convenient time for your business. We serve customers in Dania Beach, Miami, Hollywood and the surrounding area.


text:
Q: Get sub-range address from other sheet In my other question, I can get the sub-range of a range by using INDIRECT and CELL: Calculate PRODUCT of a sub-range in a Google Sheets range
However, If I use the formula in another sheet, it will show #REF!:

Error
  Function INDIRECT parameter 1 value is 'Sheet1!$I$2:Sheet1!$I$17'. It is not a valid cell/range reference.

I know that the format should be Sheet1!$I$2:$I$17 but I wonder how can I do that?
Example sheet: https://docs.google.com/spreadsheets/d/1byIjDzHZE6s5N1PcN9yvSeC51bm9NVVC1tc1gjQQLHA/edit#gid=462032657
It could be better if I can use named range for this.

A: Where you get this Sheet1!$I$17 you might enclose it in:
REGEXEXTRACT(..., "[^!]+$")

This will cut off sheet's name from the cell name.
But you've got a nice solution in that question where you can use OFFSET and forget about string manipulations for INDIRECT. And it will still work when you copy it to different sheet.

A: Here's a tidy little solution that i've left for you on Sheet1 in cell R9:
=ARRAYFORMULA(PRODUCT(B2:N21^((A2:A21<=R3)*(B1:N1=R4))))

Cheers!

redpajama_set_name: RedPajamaStackExchange


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You are here: Home > Disease analysis > Central Nervous System > Depression Disease Market and Forecast Analysis 2024
Author: Stephanie Yip
Datamonitor Healthcare estimates that in 2018, there were 223.1 million prevalent cases of major depressive disorder (MDD) worldwide, and forecasts that number to increase to 248.9 million prevalent cases by 2027.
The drug market for depression is projected to expand in the next 10 years, propelled by a growing patient caseload and uptake of new products approved for indications beyond MDD, including post-partum depression (PPD), treatment-resistant depression (TRD), and suicidal ideation.
The primary distinguishing factor in the depression market is a drug's ability to satisfy unmet needs. The latest market entrants, Spravato and Zulresso, have appeared highly attractive in their capacity to fulfill needs through their approvals for difficult-to-treat patient populations coupled with their refreshing first-in-class mechanisms. Novelty in mechanism of action is a key differentiator that has finally reached the depression market after decades of stagnated innovation, since long-standing standard-of-care drug classes have been inadequate in treating depression. Traditional therapies may take four to six weeks to produce clinically meaningful effects, and refractory depression persists.
Serotonergic antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are forecast to be dethroned from their market-leading positions by pioneering drug classes: steroidal antidepressants and N-methyl-D-aspartate (NMDA) receptor modulators. Although growth of the SSRI market will be spearheaded by Trintellix, traditional serotonergic antidepressants have largely been insufficient in treating depression, and the market is characterized by critical unmet need. This poses prominent opportunities for new therapeutic classes to diverge from the sluggish growth trends of established drug classes. Combined sales of the novel products Spravato, Zulresso, SAGE-217, AXS-05, d-methadone, and seltorexant will greatly expand the depression market.
Sage Therapeutics' steroidal antidepressant franchise will expand the market. The Phase III drug SAGE-217 is anticipated to become a market-leading brand, boasting a broad label to treat PPD, MDD, and co-morbid MDD with insomnia. Its launch for MDD as a monotherapy will be its greatest opportunity as it may be prioritized in the largest patient population. It will be the only launch for this indication that offers convenient, short-course oral dosing, a rapid onset of action, and a new approach to treatment that makes it very competitive compared to currently marketed therapies.
In the PPD space, SAGE-217 will build on the market share of its sister product and first-to-market drug for PPD, Zulresso. Despite access hurdles resulting in a slow ramp-up in initial sales since launching in the US in June 2019, Zulresso possesses a robust clinical profile with remarkable, potent effects at 60 hours post-dose. Zulresso patients are expected to switch to the more conveniently administered SAGE-217 following initial Zulresso regimens. This synergy will make Sage Therapeutics' brexanolone franchise a formidable one.
First launched in the US in 2019, Spravato is expected to become a blockbuster brand. Johnson & Johnson has characterized its product well through extensive global studies that consolidate physicians' off-label experience with the related drug ketamine. Crucially, the first-in-class drug is the second product approved by the FDA for TRD and has the potential to confer fast-acting benefits. Furthermore, it is also approved to treat MDD patients with suicidal ideation and behavior.
Axsome Therapeutics' multi-modal drug AXS-05 is an NMDA receptor antagonist, sigma-1 receptor agonist, and an inhibitor of the reuptake of monoamines. While the company plans to file for a single approval to treat MDD in Q4 2020, the drug also has potential to broadly target different lines of therapy, from first-line and antidepressant-unresponsive MDD patients to TRD and patients with suicidal ideation, depending on the outcome of further trial investigations. Thus, Spravato will be a key competitor as it occupies later lines of therapy. While Spravato holds the benefit of earlier market entry, AXS-05 may secure a broader label and would offer the convenience of oral administration compared to Spravato's intranasal spray administered by a healthcare professional.
D-methadone is a clinically promising pipeline drug that would expand the NMDA class and enter as a more convenient oral competitor to Spravato for TRD. Demonstrating strong efficacy data with fast clinically meaningful responses at Phase III would allow d-methadone to be a significant competitor, especially if Relmada successfully expands investigations into MDD and enters into a strategic partnership to pool resources.
Seltorexant is yet to produce convincing, robust clinical trial data as the drug's efficacy appears to taper over time. Nevertheless, Johnson & Johnson is moving forward with Phase III investigations into seltorexant as an adjunctive treatment of MDD with insomnia symptoms since greater efficacy was evident in this patient population.
Although there are vast opportunities for new drugs to achieve substantial sales, there are also risks. Potential barriers to eventual uptake include costliness hindering market access, safety issues that necessitate strict REMS programs, and niche target populations which will reduce a product's commercial potential.
Most long-established brands will not enjoy blockbuster growth. The only prominent established brand is Trintellix, and its strong clinical profile for MDD will continue to drive robust sales growth until its patent expiry in 2026 in the US. In contrast, sales of most traditional brands will generally continue to contract as ever-intensifying generic competition progresses through the forecast period covered by our analysis. Fetzima and Rexulti, which are yet to be impacted by generic erosion, will struggle to ramp up the same sales momentum in the crowded generic climate, primarily because they are not distinct enough from existing therapies in their mechanisms and indications. Their lack of novelty is in stark contrast to the new approaches presented by pipeline drugs for MDD such as SAGE-217 and AXS-05.
10 DISEASE BACKGROUND
10 Definition
10 Subtypes
11 DSM-5 diagnostic criteria – MDD
12 DSM-5 diagnostic criteria – PDD
14 DSM-5 specifier – depressive disorder with peripartum onset
15 Treatment-resistant depression
15 Etiology
16 Prognosis
17 Standard treatments
17 Novel treatments
17 Treatment guidelines
41 Same Price & Trial Data: Scotland OKs Spravato Funding After England Says No
41 NICE Updates Neurostim Guidance For Depression, Epilepsy
41 US FDA Opens Door For J&J's Spravato To Another MDD Population
41 Acadia Hit By Two Surprise Disappointments With Nuplazid
42 J&J's Spravato Gets EU Okay For Drug-Resistant Depression
42 Last-Minute Pushback On Janssen's EU Spravato Approval
44 Dealmaking Quarterly Statistics, Q3 2020
44 Finance Watch: Axsome Therapeutics
56 Pioneering drug classes will surpass serotonergic antidepressants as the most lucrative classes
56 Sage Therapeutics' steroidal antidepressant franchise will expand the market
56 NMDA receptor modulators will garner significant share, with particular benefits towards more severe patients
57 Co-morbid insomnia is an area of opportunity that is yet to be realized
57 Barriers to uptake include cost, REMS programs, side effects, and small target populations
57 Most long-established brands will not enjoy blockbuster growth
63 SAGE-217 for Major Depressive Disorder (October 15, 2020)
63 PRAX-114 for Major Depressive Disorder (September 25, 2020)
64 Nuplazid for Major Depressive Disorder (July 20, 2020)
66 AXS-05 for Major Depressive Disorder (March 30, 2020)
68 MIN-117 for Major Depressive Disorder (December 18, 2019)
69 AXS-05 for Major Depressive Disorder (December 16, 2019)
72 SAGE-217 for Major Depressive Disorder (December 5, 2019)
75 AV-101 for Major Depressive Disorder (November 14, 2019)
76 d-Methadone for Major Depressive Disorder (October 15, 2019)
78 Seltorexant for Major Depressive Disorder (October 1, 2019)
79 Spravato for Major Depressive Disorder (September 10, 2019)
81 Spravato for Major Depressive Disorder (September 9, 2019)
82 Multiple Drugs for Major Depressive Disorder (June 25, 2019)
83 Seltorexant for Major Depressive Disorder (May 13, 2019)
85 AXS-05 for Major Depressive Disorder (May 6, 2019)
86 AV-101 for Major Depressive Disorder (May 2, 2019)
89 UNMET NEEDS AND KEY OPINION LEADER INSIGHTS
89 More effective therapies for treatment-resistant depression
89 Additional therapy choices for post-partum depression
89 Onset of action
90 Treatments for MDD with suicidal ideation
23 Figure 1: Trends in prevalent cases of MDD, 2018–27
32 Figure 2: Overview of pipeline drugs for MDD in the US
32 Figure 3: Pipeline drugs for MDD, by company
33 Figure 4: Pipeline drugs for MDD, by drug type
33 Figure 5: Pipeline drugs for MDD, by classification
43 Figure 6: Probability of success in the MDD pipeline
45 Figure 7: Clinical trials in MDD
45 Figure 8: Top 10 drugs for clinical trials in MDD
46 Figure 9: Top 10 companies for clinical trials in MDD
46 Figure 10: Trial locations in MDD
47 Figure 11: MDD trials status
48 Figure 12: MDD trials sponsors, by phase
51 Figure 13: Datamonitor Healthcare's drug assessment summary for depression
55 Figure 14: Market dynamics in depression
56 Figure 15: Future trends in depression
66 Figure 16: Nuplazid for Major Depressive Disorder (July 20, 2020): Phase III – CLARITY-2, Phase III – CLARITY-3
68 Figure 17: AXS-05 for Major Depressive Disorder (March 30, 2020): Phase III – STRIDE-1 (TRD)
72 Figure 18: AXS-05 for Major Depressive Disorder (December 16, 2019): Phase III – GEMINI
75 Figure 19: SAGE-217 for Major Depressive Disorder (December 5, 2019): Phase III – MOUNTAIN (MDD-301)
76 Figure 20: AV-101 for Major Depressive Disorder (November 14, 2019): Phase II – ELEVATE
78 Figure 21: d-Methadone for Major Depressive Disorder (October 15, 2019): Phase IIa – TRD (Adjunctive)
81 Figure 22: Spravato for Major Depressive Disorder (September 10, 2019): Phase III – ASPIRE II
82 Figure 23: Spravato for Major Depressive Disorder (September 9, 2019): Phase III – ASPIRE I
85 Figure 24: Seltorexant for Major Depressive Disorder (May 13, 2019): Phase IIb – Adjunctive to Antidepressants
88 Figure 25: Key upcoming events in MDD
11 Table 1: Depression subtypes as classified by the US National Institute of Mental Health
12 Table 2: MDD diagnostic criteria
14 Table 3: PDD diagnostic criteria
18 Table 4: Depression treatment guidelines in the US and UK
22 Table 5: Prevalent cases of MDD, 2018–27
25 Table 6: Marketed drugs for MDD
34 Table 7: Pipeline drugs for MDD in the US
63 Table 10: SAGE-217 for Major Depressive Disorder (October 15, 2020)
64 Table 11: PRAX-114 for Major Depressive Disorder (September 25, 2020)
65 Table 12: Nuplazid for Major Depressive Disorder (July 20, 2020)
66 Table 13: AXS-05 for Major Depressive Disorder (March 30, 2020)
69 Table 14: MIN-117 for Major Depressive Disorder (December 18, 2019)
70 Table 15: AXS-05 for Major Depressive Disorder (December 16, 2019)
73 Table 16: SAGE-217 for Major Depressive Disorder (December 5, 2019)
75 Table 17: AV-101 for Major Depressive Disorder (November 14, 2019)
77 Table 18: d-Methadone for Major Depressive Disorder (October 15, 2019)
79 Table 19: Seltorexant for Major Depressive Disorder (October 1, 2019)
80 Table 20: Spravato for Major Depressive Disorder (September 10, 2019)
81 Table 21: Spravato for Major Depressive Disorder (September 9, 2019)
83 Table 22: Multiple Drugs for Major Depressive Disorder (June 25, 2019)
84 Table 23: Seltorexant for Major Depressive Disorder (May 13, 2019)
85 Table 24: AXS-05 for Major Depressive Disorder (May 6, 2019)
87 Table 25: AV-101 for Major Depressive Disorder (May 2, 2019)
M&A Outlook 2018
PharmaVitae explores the rationale for accelerated dealmaking in 2018, earmarking companies touted for M&A activity, and details 27 targets that potential acquirers should prioritize based on strategic themes, KOL interviews, and physician surveys.
April 24, 2018 $3,000.00
Interventional Cardiology Vascular Stents
The global market for vascular stents is being driven by the increasing prevalence of cardiovascular disease (CVD). CVD is the leading cause of death globally, responsible for over 17 million deaths annually.
January 25, 2018 $599.00
2018 Biomedtracker / Meddevicetracker / Datamonitor Healthcare Post-ACC Report
The American College of Cardiology (ACC) 66th Scientific Session was held in Washington, DC from 17–19 March 2017.
April 06, 2018 $599.00
Trends in CNS Dealmaking, 2012–16
Diseases of the central nervous system (CNS) offer considerable opportunity to drug developers and marketers.
August 08, 2017 $2,995.00
Extremity Replacement Implants Diabetes Management: Insulin Pumps Market (2020)


text:
DESPERATELY SINGING SUSAN?
Sweet the Demon appeared in only one episode of 'Buffy The Vampire Slayer' ("Once More With Feeling"), in which he forced humans to confront their innermost feelings and desires through song and dance. (This often led to their spontaneous combustion.)
Yet he still was inducted into the TV Crossover Hall of Fame with an honorary membership back in October of 2005. That's because it's my belief that he's responsible for such song-and-dance adventures in Television as 'Hull High', 'Cop Rock', and a childhood fave, 'That's Life' from 1968.
Now it looks as though Sweet the Demon will strike again in Toobworld, this time on Wisteria Lane in Fairview, California.
Here's what Liz Smith said in Variety:
"MARC CHERRY, producer-creator of ABC's 'Desperate Housewives,' wants to keep things blooming, ratings-wise on Wisteria Lane. Cherry is considering a musical episode."
We don't have to see Sweet actually show up to know that he's at work behind the scenes.
My only question is whether or not his demonic influence extends beyond the grave. Do you think we'll be hearing a song from the undead narrator, Mary Alice Young?
Toby OB
Labels: Blogmates, Hall of Fame, O'Bservations, TV Classique, Twipped from the Headlines
MIND OVER MADACORP
After TVSquad published their review of the latest episode of 'Kyle XY', I wrote in with this comment:
Maybe I read more into the episode than I should have, but I think MadaCorp was behind the buy-out of Stephen's company. The long-term plan? With money about to be tight in the Trager household, Nicole would be amenable to taking on a new client (Jessi XX).
And they never did I.D. the company that bought out Stephan's, so it's a possibility.
Posted at 1:40AM on Jul 7th 2007 by Tele-Toby
Isabelle Carreau, who wrote the review responded with this:
Or, while we are speculating, how about the company was bought by whatever other company but that Stephen lands a job with Madacorp not knowing its ties with Kyle?
Posted at 8:33AM on Jul 7th 2007 by Isabelle Carreau
We'll just have to wait and see how it plays out during the sophomore season for the show.....
Labels: Blogmates, La Triviata, O'Bservations
D'OH, THE HUMANITY!
Even though I knew it would be laden with commercials, I re-watched the second Christmas special for 'Doctor Who', "The Runaway Bride". I hadn't seen it since January (thanks pseudo-kid) and only the one time, so I wanted the chance to re-examine the performance of Catherine Tate. With the announcement of her return to the series as Donna Noble for the full run of the fourth season, I wanted to see if the fanboys in various wankboards had a legitimate reason to gripe about the casting.
I'll get this out of the way straight-off. I'm not a fan of her work in general. There's just something grating about the characters she's created for her show. And that certainly applies to Donna - for the first fifteen minutes or so of the introduction. It's such a powerful approach which she takes that I think that's what was seared into the minds of the viewers who had negative comments about her. By the end of the episode, she had begun to mature, and she promised the Doctor as they said their goodbyes that she would go out into the world and be magnificent.
It will be this new Donna who will be rejoining the Doctor, not the shrill Bridezilla termagant we first met.
Still, as I said earlier, I'm not that big a fan and I'm not looking forward too much to seeing her every episode. However, I'm willing to give RTD (mostly his other writers) the benefit of the doubt when it comes to writing the role. We'll see how it goes.
Anyhoo, that's not what I'm on about today. It was during her introduction scene that an exchange of dialogue came up which made me wonder if it was a harbinger of what would come later in the third season.....
THE DOCTOR: Are you human?
DONNA NOBLE: Is that even an option?
THE DOCTOR: It is for me, yeah.
At the time I first watched "The Runaway Bride", I think I considered that a reference to his supposed human genetic background. (I'm still of the belief that as part of his personality quirks, the Eighth Doctor was lying to Grace about his mother being human just so he could shag her.)
But now, having seen the two-parter "Human Nature"/"Family Of Blood", maybe it was a clue about the Chamelion Arch feature of the TARDIS and its function. If so, then it was a very subtle layout for the groundwork so that in hindsight the Chameleon Arch no longer looks like it was a plot device pulled out of the hat at the last moment.
Or I could just be reading more into it than intended. That's usually how I operate.....
"The never-ending fountain of fat, stupid trivia!"
That really out to be in my job description as a televisiologist!
Labels: As Seen On TV, O'Bservations, Who's On TV
PUTTING FOURTH
Ever since I started "Inner Toob", I've found less time, and quite frankly, less interest, in posting to the Idiot's Delight Digest (my first big reason to join the world of the Internet). Everything I want to say, I can just as easily say here.
But occasionally I do add comments to other TV sites, and even to the IDD. And being the lazy bastid that I am, there were a couple of salient points I made recently that I thought I could just as easily have shared here.
So I will.
Here's one about the cancellation of 'The Loop' from Alan Sepinwall's blog, "What's Alan Watching" (link to the left):
Toby said...
Perhaps it's just as well that 'The Loop' is now history; let it go out with its lack of dignity intact before the network suits (may they be nibbled to death by ducks!) diddled with it some more in order to please whosever butt Murdoch has to smooch to buy up more media outlets.
It was a funny show and will have its place in my DVD collection. (I already have season one).
Should there have been more? I'd say so, but 'Fawlty Towers' went out with 12 episodes and kept its reputation unsullied by going on too long. Maybe in the long run, that's what's best for 'The Loop' as well....
And then I pestered the fine folks in Rob Buckley's "The Medium Is Not Enough" (also with a link to the left) with my take on the pilot of 'Burn Notice':
I enjoyed the pilot a lot and plan to come back for more.
Especially liked Campbell as that kind of rummy friend you'd find in 'To Have And Have Not' and 'Islands In The Stream', plus all those movies where that same rummy might just sell you out....
The pilot triggered the alarms for one of my viewing rules: if they give you ancillary info that doesn't seem to have much to do with the story at hand, it'll be important later.
A lot was made about Westen's relationships with his late father and his brother Nate. Of course, it was probably there to bring some shading to his background and fill in the family history, but I think there'll be more to it than that.
Not only do I think we're guaranteed to meet Nate down the road, but I think his father will turn out to be still alive as well.
And either one of them in complicit in his burn notice.
I guess we'll see....
Posted by Toby OB July 2, 2007 9:14 PM
And finally, back in my old stomping grounds of the Idiot's Delight Digest, I tried to drum up some dialogue among the Iddiots with this assessment of 'Rescue Me':
Here's another TV-related question like last week's re: 'John From Cincinnatti':
Anybody else watching 'Rescue Me'? What did you think about last week's episode?
I didn't think that was in the Chief's nature at all, and it means the loss of a great character on that show - one of the few worth watching.
Gonna miss Jack McGee.
And I'm sick of ALL the Denis Leary plotlines. It's beyond belief that so many women are throwing themselves at him; I can't see that at all. (He looks like my cousin, so that's probably why.) He's upped the ante on the Job factor with Tommy so much that he makes it look like Andy Sipowicz was Mr. Sunshine!
Maybe he should follow through on his threat to kill off more on the show by offing Tommy and then he can just produce the series.
I wish they did kill off Sheila on the show. I liked Callie Thorne a lot on 'Homicide: Life On The Street', but Sheila is too much now. She could have stuck around as a ghost, that's fine. But she's killing the energy by eating up so much of the plotline.
Not sure how much longer I'll stick with it with most of the storylines either ridiculous, non-existent, or unbearable to think about. (Janet with the baby is creeping me out as to what may happen...)
Still like Probie, and Uncle Teddy is fun to watch, even if it seems like he is in his own show.
Okay, just wanted to see some movement in here.....
And I just wanted to spare myself actually writing up something original on the holiday. Bad enough I have to work it when it's also my day off, but to do actual research for a new post seems downright un-American!
Buy Bonds!
Labels: Blogmates, IDD, My So-Called Life, O'Bservations, Toobworld Central
7/2/07: NEW @ TOOBWORLD CENTRAL
While working on that last piece about Seattle, I received a package from my pusher of choice, Amazon.com!
Here are the latest additions to the libraries of Toobworld Central:
"Doctor Who: The Completely Unofficial Encyclopedia"
I realize publications like this are outdated as soon as they're printed, but it's always nice to have one around as a starting point for research. And there is mention of Martha Jones, so it's as up-to-date as possible...
1-2] 'Dead Like Me' - Seasons One & Two
My buddy Michael turned me on to this show. (I don't get Showtime, and wasn't enthusiastic about seeing them censored on Sci-Fi.) When he made his first attempt with the pilot, I felt very lukewarm about the whole thing. But a couple of weeks ago he showed me a few more episodes and every time he asked if he should play another, I nodded - I guess I was just in a better frame of mind by then to hang out with Rube and the gang at the Waffle House!
Poor Michael - It's one more hold he doesn't have over me. Oh well, at least he and Mark still control my access to the new Whos, Torchwoods, and the upcoming Sarah Janes ::sigh...::
3] "The Lord Of The Rings" animation trilogy
Collected in one "set" (just the three disks in the same shrink wrap, really - no fancy box), these are the two Rankin-Bass TV movie specials, "The Hobbit" and "The Return Of The King", and the feature film by Ralph Bakshi, "The Lord Of The Rings".
I'm hoping to introduce my 2½ year old nephew to "The Hobbit" this summer (last Thanksgiving it was "The Wizard Of Oz"), but I think he's a bit too young for the Bakshi movie.....
Labels: My So-Called Life, Toobworld Central, TV Classique, Who's On TV
CROSSING AMERICA: SEATTLE
It's the beginning of Fourth of July week and many people across America are thinking the same thing: Vacation Road Trip! And with that in mind, I'm celebrating by looking at a particular destination and its place in Toobworld's geography.
So let's bug out for....
SEATTLE!
With the summer TV schedule underway, two shows have returned which both take place in Seattle, Washington,: 'The 4400' and 'Kyle XY'. And during the regular season, there's also 'Grey's Anatomy', also in the "Emerald City".
These shows couldn't be more different from each other. Although 'The 4400' and 'Kyle XY' are both sci-fi, the focus for 'Kyle XY' is more on being a family drama. And of course, 'Grey's' is a medical soap opera.
To actually have them cross over with each other would probably ruin the host show's believability for its core audeince. But crossovers don't have to be overt, with characters and plotlines overwhelming the usual storylines; it could all be done with just some tossed-off dialogue which utilizes the trivial touchstones from each series:
'Grey's Anatomy' - Seattle Grace Hospital
'The 4400' - the 4400 Center, NTAC, promycin
'Kyle XY' - MadaCorp., Kyle's high school, a kid with no belly button, for bleep's sake!
On 'Grey's Anatomy', someone might mention that the emergency room reported another promycin related death. Another could remark that a particular case wasn't as strange as that one about the kid with no belly button....
Both 'The 4400' and 'Kyle XY' could mention Seattle Grace as an option for hospital treatment.
I'm not sure Tom Foss and his lawyer buddy would ever risk the use of promycin on Kyle's already-enhanced physiology. But they might discuss it should Kyle ever express an interest in visiting the 4400 Center.
NTAC might investigate Kyle (or even Jessi XX) as a possible recipient of a promycin shot; NTAC could also initiate a lockdown crisis at Seattle Grace.
And perhaps Kyle's friends Josh and Declan might entertain the notion of trying the promycin themselves; to bring them up to par with Kyle.
Plenty of other shows have been set in Seattle over the years. References could be made to them, and so subtly that not even the producers of the original series would realize their shows had been involved.
For example, every week on 'The 4400' we meet new citizens of Seattle, not all of them part of the original 4400, or even with new powers. But some of them could have the same last names as the family surnames from those older Seattle-based shows. Then it's just a bit o' wish-craft if we make the connection.
(I ran a check on some of the names and came up with the character of Josh Sandler from the episode "Blink". He had been a grad student engaged to Diana, but she called off the wedding over a week before the big day because she found out he had been cheating on her. He's now an astronomy professor, and there's no over-riding reason why he couldn't be related to the Sandlers of 'Good & Evil'.)
Here are two of the best surnames that could come into play on these three other TV shows:
Bolt - 'Here Come The Brides'
Crane - 'Frasier'/'Domestic Life'
(More on these two titles coming soon!)
Ya gotta have those two family names pop up! And to top it off, why not mentions of KCAL radio ('Frasier') and Bridal Veil Mountain ('Here Comes The Brides')? We could hear a KCAL deejay give an update on some NTAC investigation, or on a critical emergency at Seattle Grace Hospital. As for Bridal Veil Mountain, perhaps that's where Kyle woke up naked in the woods? Perhaps that's where Jessi XX strangled that camper.
(Another place that might get mentioned, especially on 'Grey's Anatomy', would be 'University Hospital'......)
Here are a few more surnames to use:
Guevera - 'Dark Angel'
Semple - 'Here Comes The Brides'
Trapchek - 'Traps'
Henderson - 'Harry And The Hendersons'
Gardner - 'A Year In The Life'
Torkelsons - 'Almost Home'
Sandler - 'Good & Evil'
Langston - 'Under One Roof'
Hatton - 'One Big Family'
The following names might be too generic to get anyone to think they were connected to other shows, unless you got the original actors to appear and reprise their roles:
Taylor - 'Haunted'
Miller - 'Romeo!'
Black - 'Millennium'
Of course, there could always be some mention of the mysterious Millennium Group, and how their plans for 2000 never came to pass....
And then there's 'Dark Angel', which purports to take place in the post-apocalyptic Seattle of 2019. It's only a dozen years away and the way the world is today, who knows? Maybe it will come to pass. (Otherwise, I think it has to be relegated to some unknown future in an alternate TV dimension.)
The secret organization that was breeding those genetically superior children might be related to, or grown out of, MadaCorp. from 'Kyle XY'. And whether that future comes to pass or not could depend on what happens in the future episodes of the ABC Family show.
So there you have it, our summer road trip to the televersion of Seattle in Toobworld. If you plan on visiting this summer, I hope it doesn't rain!
My thanks to TV Acres for much of the Seattle information... information... information...
The bluest sky you've ever seen,
In Seattle.
And the hills the greenest green,
Like a beautiful child
Growing up, free and wild.
Full of hopes and full of fears,
Full of laughter, full of tears,
Full of dreams to last a year
'Here Come the Brides'
Labels: Alternateevee, Blogmates, By Any Other Name, La Triviata, Linkin' Haze, O'Bservations, TV Classique, TV timeline, Wish-Craft
THE TVXOHOF MID-YEAR REPORT
For those of you unfamiliar with the concept, the TV Crossover Hall of Fame was established in 1999 to honor those TV characters (as well as locations and objects) which unify the TV Universe. This includes real-life people who have fictionalized tele-versions of themselves, as well as the Creators who make the crossovers possible.
The original requirements have become easier to achieve in recent years (appearances in three different TV shows, TV movies, cartoons or commercials). But that's mostly due to the fact that those who make the TV shows nowadays grew up watching TV and love the self-referential nature of the medium. But it has reached the point where some might argue that just about anybody can get into the Hall of Fame.
And in 2005, that was just about true....
Every year on my birthday, I celebrate in my blog (or the old Tubeworld Dynamic website before this) by announcing a Birthday Honors List; inducting someone special into the ranks of the Hall of Fame who might have just missed the requirements but who is nonetheless deserving of recognition for their contributions to the TV Universe.
My mantra for the choices made on my birthday is: "What I say, goes."
The first such honoree was Suzy MacNamara, Ann Sothern's character in 'Private Secretary'. She was honored because she was involved in the first TV crossover, on the premiere episode of 'The Lucy-Desi Comedy Hour'.
Let's run down those who have been inducted so far this year:
JANUARY - Johnny Carson
FEBRUARY - Florence Johnston
MARCH - Lou Grant
APRIL - The Doctor
MAY - Sarah Jane Smith
JUNE - Charlie Pace/Oceanic Airways
HONORS - Brigadier Alistair Lethbridge-Stewart
JULY - Bret Maverick
I've been running the TV Crossover Hall of Fame since 1999, and one day I will devote the time necessary to create a permanent home for it on the web.
If you're interested in seeing the full list (There are nearly 200 members so far!), then drop me a note at:
Tubeworld@aol.com
Labels: Hall of Fame, O'Bservations, Toobworld Central, TV Classique
JULY 2007 TVXOHOF: ACE HIGH
For the July ceremonies of the TV Crossover Hall of Fame, we're going to veer off from the mini-theme of celebrating 'Doctor Who' in order to mark a long-standing tradition of the old Toobworld Dynamic - honoring the TV Western in July.
I could have kept the 'Who' theme running anyway by inducting an historical figure of the Wild, Wild West - the televersion of Doc Holliday. (Wyatt Earp - in the guise of Hugh O'Brian - entered the Hall back in 2002.) But that would have been a cheat, because in the Toobworld design of the TV Universe, the Doctor didn't actually visit the OK Corral on that fateful day of the Shootout.
I'll splain further later in the month....
Instead, it's my pleasure to announce that my favorite TV "cowboy", one of my Top Ten favorite TV characters no matter the genre, is finally being allowed to join the pantheon of crossover legends.
BRET MAVERICK
The strange thing is that even though he turned the Western genre on its head, and the character was the jump-start to James Garner's career in movies and TV, Bret was not the first character from 'Maverick' to be inducted into the Crossover Hall of Fame. His brother Bart made it in first, and even recurring character Samantha Crawford found her way into the Hall as one of the year-long Honors List from 2005, when I was celebrating my fiftieth birthday.
Bart entered first because at the time, 2001, he had a wider variety of actual Television crossovers to his credit:
'Maverick'
"Young Maverick"
'Bret Maverick'
"Gambler 4: Luck Of The Draw"
Add to that, one of his episodes from the original series, "Hadley's Hunters", featured appearances by characters, locations, or props from 'Cheyenne', 'Sugarfoot', 'The Lawman', 'Bronco', 'Colt .45', and 'Wanted: Dead Or Alive'. (Plus an earlier incarnation of the soul of Kookie Kookson from '77 Sunset Strip'.)
Bret only had those first three appearances, even if he did make the franchise possible.
But he also had a theatrical release which gets the kind of consideration reserved for the Honors List, in that it could be seen as theoretical. James Garner played the role of Zane Cooper in the movie version of "Maverick", which also starred Mel Gibson as Bret, Jodie Foster, and James Coburn. (This was the third movie Garner and Coburn appeared in together, and they worked together in an episode of 'Maverick'.)
He may have been Zane Cooper through most of the movie, but it turns out in the end that he's Bret's father.
Well then! Zane Cooper was just an alias. O'Bviously he must have been Bret Maverick, Sr. and thus, the Maverick we knew from the TV show.
Whether you want to consider that addition to be legit or not, Bret still has enough credits, three of a kind you might say, to guarantee him entry.
So, riverboat, ring your bell and welcome the gentleman gambler as our July 2007 representative from the Wild, Wild West in the TV Crossover Hall of Fame!
Labels: Big Screen TV, By Any Other Name, Hall of Fame, Linkin' Logs, O'Bservations, TV Classique


text:
Territorio di Verona
Stock# 31430sm
Jan Jansson
Publication Place / Date
Amsterdam / 1640 circa
Hand Colored
Sell Us a Map
Nice old color example of Jansson''s map of the Territory of Verona, centered on Verona and Lago di Garda.
Decorative title cartouche and scale of miles.
Old Color. Minor offsetting.
Jan Jansson Biography
Jan Janssonius (also known as Johann or Jan Jansson or Janszoon) (1588-1664) was a renowned geographer and publisher of the seventeenth century, when the Dutch dominated map publishing in Europe. Born in Arnhem, Jan was first exposed to the trade via his father, who was also a bookseller and publisher. In 1612, Jan married the daughter of Jodocus Hondius, who was also a prominent mapmaker and seller. Jonssonius' first maps date from 1616.
In the 1630s, Janssonius worked with his brother-in-law, Henricus Hondius. Their most successful venture was to reissue the Mercator-Hondius atlas. Jodocus Hondius had acquired the plates to the Mercator atlas, first published in 1595, and added 36 additional maps. After Hondius died in 1612, Henricus took over publication; Janssonius joined the venture in 1633. Eventually, the atlas was renamed the Atlas Novus and then the Atlas Major, by which time it had expanded to eleven volumes. Janssonius is also well known for his volume of English county maps, published in 1646.
Janssonius died in Amsterdam in 1664. His son-in-law, Johannes van Waesbergen, took over his business. Eventually, many of Janssonius' plates were sold to Gerard Valck and Pieter Schenk, who added their names and continued to reissue the maps.
Antique Maps / Europe / Italy / Italy
Antique Maps / Europe / Italy / Northern Italy


text:
East Coast Car Rentals > Latest News > It's time for all you Baz Luhrmann fans to visit Sydney
It's time for all you Baz Luhrmann fans to visit Sydney
August 8, 2013, chris Sydney
If you're a fan of Baz Luhrmann, now could be the perfect time to purchase a plane ticket, organise a rental car at the Sydney airport and prepare yourself for the event of a lifetime!
You may not be familiar with this legendary Australian director's name, but you'll no doubt have heard of at least one of his blockbuster films.
His fast-paced, quirky and often comedic style of cinematography was most recently seen in The Great Gatsby, which was released earlier this year and garnered rave reviews.
However, he is probably still best known for his 'Red Carpet Trilogy', which included Strictly Ballroom, Romeo and Juliet, and the wildly successful Moulin Rouge.
The first of these three movies was set and filmed in Australia, and early next year it will be returning home in a different – and very exciting – capacity.
Strictly Ballroom has been adapted for the stage, and will begin showing in theatres from March 25, 2014. Tickets to attend the premiere performance in Sydney are going on sale at 9am this coming Monday (August 12) – so make sure you're sitting in front of your computer at that time!
NSW Premier Barry O'Farrell was instrumental in making sure Sydney was the first place in Australia to see Strictly Ballroom: The Musical.
During a press conference in Sydney earlier this week, Baz Luhrmann said that he has "often marvelled at how this story, born so long ago, has been in [his] life for so many years and has
managed to touch, move, entertain and uplift so many different people from so many different backgrounds".
He said that despite the glitz and glamour of the original production, the message of the film is quite simple: "There isn't only one way to cha cha cha, and … within us all we have the
true potential to dance our steps."
For those who adore the film and are worried the stage version just won't be the same, never fear – the creative team who worked tirelessly on the 1992 film will be reuniting to create this musical extravaganza.
Baz Luhrmann, who directed and co-wrote the original film, along with Craig Pearce (co-writer), John O'Connell (choreographer) and Catherine Martin (set and costume designer) are all going to be involved, and will make sure everything that made the screen version spectacularly successful will be translated onto the stage effectively.
The musical's many song-and-dance numbers have also been adapted from pieces used in film. All your favourites, such as Love is in the Air and Time After Time, will make an appearance alongside a few original songs.
If you miss out getting tickets to the premiere of Strictly Ballroom: The Musical, don't worry – we're sure every subsequent performance will be just as magnificent!
And, of course, there are a variety of other ways you can demonstrate that you are a true Baz Luhrmann fan.
If you want a relaxing night in after days of sightseeing and driving around the city in your rental car from Sydney, why not visit the nearest DVD store and rent a few of his films to watch?
Or, if you want to take a road-trip in honour of this great Australian director, why not head to Bowen, Queensland, in your rental car?
Why Bowen, you ask? This is where parts of the 2008 film Australia were shot. This starred Hollywood heart-throbs (and, more importantly Australian-born actors) Nicole Kidman and Hugh Jackman.
We encourage you to drive around the area and see if you can recognise any of the scenery from the movie. Don't forget to take heaps of photos!


text:
Q: JavaScript onLoad function + IE = problems I'm working on a school project which should give students the ability to search institutes and extra information about them.
After the search the results are displayed like this: can't show image, have to get a rep of 10, I'll do this later.
This works, I use this onLoad function:
function onLoad() {
    for (i = 0; i < document.getElementsByTagName("tr").length; i++) {
        if(document.getElementsByTagName("tr")[i].id.length != 0) {
            document.getElementsByTagName("tr")[i].style.visibility = "collapse";
        }
    }
}

but when I use IE7 I first only get a few institutes (normally 19)
Then I press on one of the plus signs which hold this function:
function uitvouwen(trId,imgId) {
var url = document.getElementById(imgId).src;
if (url.indexOf("Images/plus.gif") != -1) {
    for (i = 0; i < document.getElementsByTagName("tr").length; i++) {
        if(document.getElementsByTagName("tr")[i].id == trId) {
            document.getElementsByTagName("tr")[i].style.visibility = "visible";
        }
    }
    url = "Images/minus.gif";
} else if(url.indexOf("Images/plusbottom.gif") != -1) {
    for (i = 0; i < document.getElementsByTagName("tr").length; i++) {
        if(document.getElementsByTagName("tr")[i].id == trId) {
            document.getElementsByTagName("tr")[i].style.visibility = "visible";
        }
    }
    url = "Images/minusbottom.gif";
} else if (url.indexOf("Images/minus.gif") != -1) {
    for (i = 0; i < document.getElementsByTagName("tr").length; i++) {
        if(document.getElementsByTagName("tr")[i].id == trId) {
            document.getElementsByTagName("tr")[i].style.visibility = "collapse";
        }
    }
    url = "Images/plus.gif";
} else if(url.indexOf("Images/minusbottom.gif") != -1) {
    for (i = 0; i < document.getElementsByTagName("tr").length; i++) {
        if(document.getElementsByTagName("tr")[i].id == trId) {
            document.getElementsByTagName("tr")[i].style.visibility = "collapse";
        }
    }
    url = "Images/plusbottom.gif";
}
document.getElementById(imgId).src = url;

}
Weird enough all 19 results get displayed now
So my question is:
Does IE7 stop my onLoad code (maybe because it's too much to handle) or do I have to look for errors in my program?
On other browsers this program works perfectly..
This is the code actual HTML, JSTL and JavaScript code (I know it's messy but it's an exercise on JSTL so i need to use it):
<c:forEach var="instituut" items="${ requestScope.instituten}">
<table id="LijstResultaten<%= i %>" summary="LijstResultaten<%= i %>">
    <%
        i++;
        if (instituten.size() != i) {
    %>
    <c:set var="urlLijn" scope="session" value="Images/line.gif"/>
    <c:set var="urlMin" scope="session" value="Images/minus.gif"/>
    <c:set var="urlPlus" scope="session" value="Images/plus.gif"/>
    <c:set var="urlLijnLong" scope="session" value="Images/linelong.gif"/>
    <% } else {
    %>
    <c:set var="urlLijn" scope="session" value="Images/empty.gif"/>
    <c:set var="urlMin" scope="session" value="Images/minusbottom.gif"/>
    <c:set var="urlPlus" scope="session" value="Images/plusbottom.gif"/>
    <c:set var="urlLijnLong" scope="session" value="Images/empty.gif"/>
    <% }
    %>

        <img alt="" id="instituut<%= i %>" name="instituut<%= i %>" src="${ urlPlus}" onclick="uitvouwen('MeerInfoInstituut<%= i %>','instituut<%= i %>')" onmouseover="cursorVeranderen()" style="cursor: pointer;"/>
        ${instituut.name}

    <tr id="MeerInfoInstituut<%= i %>">

        Land:
        <%= landen.get(i - 1).getName() %>

    <tr id="MeerInfoInstituut<%= i %>">

        Stad:
        ${ instituut.city }

    <tr id="MeerInfoInstituut<%= i %>">

        Postcode:
        ${ instituut.zipcode }

    <tr id="MeerInfoInstituut<%= i %>">

        Straat:
        ${instituut.street}

    <tr id="MeerInfoInstituut<%= i %>">

        Website:

            <c:choose>
                <c:when test="${  instituut.website == 'Onbekend' }">
                    ${ instituut.website }
                </c:when>
                <c:otherwise>
                    ${ instituut.website }
                </c:otherwise>
            </c:choose>

    <%
        ArrayList<ArrayList<Outgoing_student>> studentlijst = (ArrayList<ArrayList<Outgoing_student>>) request.getAttribute("studentlijst");
        ArrayList<ArrayList<Outgoing_teacher>> docentlijst = (ArrayList<ArrayList<Outgoing_teacher>>) request.getAttribute("docentlijst");

        int aantalStudenten = studentlijst.get(i - 1).size();
        int aantalDocenten = docentlijst.get(i - 1).size();

        String resultaatStudentnamen = "";
        String resultaatDocentnamen = "";

        int j = 0;
        for (Outgoing_student studentNamen : studentlijst.get(i - 1)) {
            resultaatStudentnamen += "
\n";
            resultaatStudentnamen += "\t\t\t\t\t\t	\n";
            resultaatStudentnamen += "\t\t\t\t\t\t	\n";
            resultaatStudentnamen += "\t\t\t\t\t\t	\n";
            resultaatStudentnamen += "\t\t\t\t\t\t" + studentNamen.getFirstname() + " " + studentNamen.getLastname() + "	\n";
            resultaatStudentnamen += "\t\t\t\t\t
\n";
            j++;
        }
        j = 0;
        for (Outgoing_teacher docentNamen : docentlijst.get(i - 1)) {
            resultaatDocentnamen += "
\n";
            resultaatDocentnamen += "\t\t\t\t\t\t	\n";
            resultaatDocentnamen += "\t\t\t\t\t\t	\n";
            resultaatDocentnamen += "\t\t\t\t\t\t	\n";
            resultaatDocentnamen += "\t\t\t\t\t\t" + docentNamen.getFirstname() + " " + docentNamen.getLastname() + "	\n";
            resultaatDocentnamen += "\t\t\t\t\t
\n";
            j++;
        }
    %>
    <tr id="MeerInfoInstituut<%= i %>">

        <img alt="" id="studenten<%= i %>" name="MeerInfoStudenten" src="Images/plus.gif" onclick="uitvouwen('MeerInfoStudenten<%= i %>', 'studenten<%= i %>')" style="cursor: pointer;"/>
        Reeds bezocht door <%=aantalStudenten%> student(en)

    <%=resultaatStudentnamen%>
    <tr id="MeerInfoInstituut<%= i %>">

        <img alt="" id="docenten<%= i %>" name="MeerInfoDocenten" src="Images/plusbottom.gif" onclick="uitvouwen('MeerInfoDocenten<%= i %>','docenten<%= i %>')" style="cursor: pointer;"/>
        Reeds bezocht door <%=aantalDocenten%> docent(en)

    <%=resultaatDocentnamen%>

A: "Works perfectly" is a wide term, and in your case wrong.
Take ancient car for example.. 50 years old car that still drive (10 MPH) and still take you to the destination.... so you can say "the car is working perfectly". But it's slow and it break a lot.
Your code is the same. It's not efficient and can be improved greatly with little effort.
Anyway, your core logic is wrong as well, as IE simply does not support "collapse", see here: http://www.w3schools.com/css/pr_class_visibility.asp
I will copy the relevant part:

Note: No versions of Internet Explorer
  (including IE8) support the property
  values "inherit" or "collapse".

Bottom line, you better get back to the drawing board and find other way to achieve the design you want. jQuery is excellent choice, you have many many things available to you, just one search away.

A: just for sake and for help of course! ;)
DEMO: http://jsbin.com/ewajo3
your code should be just an example :
HTML
<tr id='caption_<%= i %>' class='tr_caption'>
  Lorem Ipsum Est <%= i %>

    <a id='show_<%= i %>' href='javascript:;' onclick='show(this.id);'>+
    <a id='hide_<%= i %>' href='javascript:;' onclick='hide(this.id);'>-

<tr id='content_<%= i %>' class='tr_content'>
  The Brown Fox Jump Hover The Lazy Dog

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You are bidding on this stunning and very in style cape! If you haven't worn a cape before, you will be pleasantly surprised.
This is a new one by MAYA MATAZARO in warm and very elegant SOFT CASHMERE fabric in a gorgeous LAVENDER color.
As with all hand dyed fabrics each one is unique, but you will get a shade of lavender the same or very close to the one in the photos.
It has no seams, so is flowing and draping beautifully and is open in the front. It is really striking and very unique!!!
and these are actual measurements: 32" long (from neck line to the longest point on the back) and 60" across.