Selling your home for money is turning into a popular option for homeowners who need to sell their property rapidly. There are very many problems in the real estate market, and many sellers find it extremely challenging getting a ready buyer for the property that they are selling. They are going for financial specialists that are prepared to purchase their property for prompt cash. Selling a house for cash is the same as pitching to a purchaser who gets conventional financing. Nonetheless, there are benefits with money exchanges that can't be gotten when the purchaser gets financing through a bank.
The most significant gains of selling your property for cash is that you can get the whole deal completed in a few days; you don't have to wait for weeks to receive your cash. There will be no forms to be filled or any extraordinary waiting time to get affirmed. In the present economy, banks are setting outrageous measures on those individuals that are keen on obtaining loans. It's a well-known fact the economy is facing great challenges. There is an expanded joblessness rate, which is making people dreadful of purchasing property as they don't have the foggiest idea if they will lose or keep up their employment. Nobody is happy to go out on a limb. About each property holder is feeling the agony from the absence of qualified purchasers. In any case, financial specialists that utilize distinctive organizations are purchasing property in different areas the country over. And they are buying such properties for cash as the loaning process is a bit complicated today. Despite the fact that the media might want to play the account that there is huge money related inconvenience, there are still financial specialists that are keen on purchasing property for money. They utilize this opportunity to grow their investments.
When you are selling your property to a private investor ready to purchase for money, you are going to gain great skills too. A significant number of them have impressive involvement in such exchanges. All of you need access to dependable information too. Short deals are especially tricky and require explicit documentation. Any person that is keen on offering their property for money needs to relinquish a portion of the benefits. They have to get a purchaser that is going to offer them money with the goal that they don't pay the premium. Working with a short sale professional can expand a fruitful result. Another advantage of selling houses for money is there is no requirement for a real estate agent. This by itself can spare a large number of dollars in commission. Legal documents are required to exchange property. Ensure that you get them. Seek the services of an attorney to make is perfect.
Many people aren't mindful of the money house selling process. Use this procedure and gain from the advantages.
The world has changed little because of technology, and there are many things you can benefit from right now. For example, think about digital audio files also known as a podcast which are available for you to download from the Internet when you have your computer or even your mobile device. Listening to the podcast can benefit you in great and diverse ways. It is very wise to understand the reason why the podcasts are actually gaining a lot of popularity, including the fact that many people find it entertaining especially when you listen to different types especially those conversations. It can also help you in learning about different issues in the society as well as about different industries which can actually broaden your understanding. It is one of the best ways of improving listening skills especially considering that when you are doing those chores that are not involving, you can listen to it. It is important to actually consider the other benefits before you can go ahead and choose them because you actually need to choose your podcast wisely and you can discover more below on how to go about it.
One of the best ways of actually ensuring that you are getting the entertainment and other benefits from a podcast, is by choosing depending on your interest. You cannot avoid choosing your podcast depending on your interest because if you are to spend a lot of time on something and actually find it entertaining, then your preferences are in play. Therefore, if you want entertainment, you want to learn about different industries, it will be very important that you choose to depend on the topic which interests you as a person and not other people because they will be listening. Therefore, when you are choosing you need to engage variety, whether novels, books and so on as you also choose variety because everything you need is available it comes to a podcast. When it is your first time, it can be a bit confusing actually to settle on one question might find everything entertaining and that is why you can involve people around you for a word of mouth recommendation because most of them might not preferences. You can on the handle are designed to try everything before you can settle on a specific topic. This is because after trying everything will be able to find your genre because they are many. This is because it is possible to discover your listening taste as you listen to many of them. You can subscribe therefore to such platforms that can be getting the series as it comes about.
Coffee is among the most used beverage. This is on the grounds that there are persons who drink coffee from the period they wake up to the period they go to sleep. The number of individuals that consume coffee increase by each year. That is why when you visit the majority of the big towns you will get that a lot of coffee shops have been opened. For this reason, you ought to make sure that every customer that walks to your coffee shop should be satisfied with the services when he/she leaves. This will ensure that these customers are able to come back again. Likewise, they may help you in marketing your shop by referring it to their friend. It is for this reason that you should make sure that your espresso machine is always clean. It is important that you make sure that the espresso machine is cleaned after closing your coffee shop. You will only take approximately 10 minutes to clean the espresso machine. Your machine will thus run without any complications. This will ensure that there are no disturbances caused during the working hours. A few of the steps that will help you to clean your espresso machine are talked over beneath.
To start with, you can use the scrubbing, rinsing and wiping method to clean your espresso machine. You should put a clean piece of cloth under water that is hot so that you can use it to wipe the wands. This will help in removing any milk stains that may be on the wands. You ought to use a coffee detergent and a scrub pad to clean the group heads. The detergent should not touch any internal part of the machine.
In addition, you can decide to soak some of the parts of the espresso machine in coffee detergent. Some of the parts that you will soak in the detergent include the group heads, steam wands, and shower screens. You should mix the coffee detergent with hot water.
To conclude, you can use the backflush method to clean an espresso machine. It is not all of the espresso machines that contain the feature of backflushing. This is especially found in espresso machines that have four valves. If you have an espresso machine that has this backflush feature, you ought to ensure that it is backflushed at least once a day by use of hot water. You should also backflush once a week by using a coffee detergent. The important thing about backflush is that you will be able to remove any contaminants that may be in the internal parts.
Once you have sold your car to the company that gives cash, you will be paid instantly. You will not have to wait for so many days before you receive the amount that you agreed on. You will only give the people who are coming for the car the directions and they will come up to where you are. Anyone who comes from the company will be aiming to see the state of that junk car that you want to sell to them. They will then quote to you the amount that they are willing to offer you. You are free to negotiate the price and come to a conclusion once you feel that the price quoted is not favorable on your side.
Selling a junk car to a company that pays cash will help you improve the appearance of your home as well as your life. Those junky cars that are found just in the front of your lawn usually bring a very bad impression. All the visitors will be imagining that you have not taken good care of your home in whole once they see this. You can relieve yourself the headache of seeing such a car in your compound every single day by just selling it. You will live a happier and peaceful life once you get this car disposed to a company that will give you some cash in return.
Once you make an effort and sell your car for cash because it is junk, you will no longer have those problems that are related to faulty car. Some of these junk cars end up eating so much money through repairs and this becomes a burden. You will find that most of these cars tend to get damaged just at the point when you want to make use of them. Once you sell this car that has become a junk and you find a replacement, you will not have to suffer again. You will leave a happy life which is stress free once you get this brand new car for yourself.
Companies that buy junk cars for cash will always ensure that you have freed up your finances. You ought to be aware that you will need so much to properly maintain your car. The excess amounts will be spend on activities such as car repairs as well as getting the car insured. For a junk car there will be need to do more and more repairs. You can decide to sell such a junk car instead and free up your finances.
By and large, we happen to be living in such a highly interconnected world as a matter of fact. Thanks to the internet and the coming in of smartphones and all the gadgets of technology we have seen of late, business and how it is done has transformed a great deal.
As a result of all this, we seen a number of entrepreneurs going online for the need to do business and a number of business websites have been opened up for this purpose. Of course just as it is often the case with the offline ventures, some succeed and some fail and this has been the case even with those who made a stint at online business.
First and foremost is the need to ensure that you have organized well enough your web assets. And talking of your web assets, these are far more than just your business. Your web assets cover virtually everything it is that will be touching on your online business and as such range all the way from your business website to your social media profiles and web hosting account. You need to make sure that you have all that goes into all this is in order for your venture into online business.
Unsure of what it is that organizing these assets entail, know that one thing that you need to ensure that you have done to organize them is to make sure that they are optimized for your very brand. A good example is to make sure that your social media pages and web pages are filled with the necessary keywords. Besides this, it pays as well to make sure that these approaches and steps fall into your integrated marketing plan. One other thing that you need not forget to put in place is the need to make sure that you have always kept these sites and pages updated with the latest and most relevant information about your company so as to communicate all that is relevant to your prospects targeted online.
Getting married is an exciting experience for numerous couples, but they should be prepared on different things to plan for a head. Estimate the number of people who want to invite to the wedding so you can decide which venue is ideal for hosting them. Every venue has a different price which is why you should identify the amount you are willing to spend so you will not have a hard time finding something within your price range.
The location of the venue is quite essential since it will determine how many guests will make it and if they will arrive on time. It is better to discuss with your wedding planner since they have better experience and will identify and negotiate the prices of the venue. Every venue has different terms and conditions which we should go through by asking for an estimate and compare it with other providers.
Couples have different themes for their wedding so start by checking photographs of various venues to see if your vision will come to life. Consulting with the venue provider regarding the book in spaces allows you to choose a wedding date which does not have any stress regarding whether the venue will be available or not. Booking the venue during weekends can be quite costly for the couple which is why you should identify a date which has lower rates.
It is everybody's drink to have an excellent venue for the wedding which is why checking out the venue personally will help you identify whether it meets your vision. If out of town guests are invited to the wedding then you need to look for a venue which is near the airport or hotels for better convenience. Before booking the venue, you should find out whether they provide catering services or whether you bring your own vendors and decker.
Every venue should have safety measures in place so you should sign a contract with them in case something happens and identify whether there are any extra charges. If you want your venue to compliment your wedding then you need to choose one, so you can pick the colors you want so there is a cohesive look. You should know what drinks are allowed in the venue by discussing with a provider.
Many people usually want to save on decor details which is lighter than vegetable to go for a more natural view. It'll be easier to trust a friend or a relative regarding the venue they booked and get recommendations of different venues you can use for your wedding event.
One very important thing regarding ASEA that you should know of is the fact that it is different from any product that has ever produced by any industry or company. As a matter of fact, ASEA does not come in the form of a medical supplement, a herbal remedy or even a multi-vitamin. You can actually say that ASEA if somewhat a new paradigm when it comes to how health is being viewed at a cellular level.
For sure, knowing that ASEA does not come in the form of multivitamins, herbal remedy, and medical supplement as well, many of you may become interested in how it usually works and to know how it really works, we have to take a good look at antioxidants. There are so many good things that come from ASEA such as the fact that it has the ability of helping protect and safeguard as well each and every one of us from radicals and toxins that may cause damage to you and your body. In addition to that, it has been said as well that these natural free radical fighters must be activated as that is the only way for them to successfully ward off cell damage.
Another thing about ASEA that you should be aware of is the fact that it represents a revolution of how natural health can be achieved by means of activating these antioxidants as well as facilitating repairs of the cells. Furthermore, we also want you to know about how the said process is pertained to as redox signaling and how it is a type of process that forces the body to heal itself, creating an impact to your health and your performance as well.
Marriage counseling is very important in any society as it will help couples to come together especially those who may have some issues in their marriage. Even though several clinics have come up to offer the services, one will need to consider the best so that they can quality services. Some factors should be considered when it comes to choosing the best clinic since the marriage counseling services usually have a variety of issues that one has to put in mind.
Some of the best clinics that offer marriage counseling services usually want to satisfy their clients of which the clinic usually receive clients who have different preferences of how they will want to receive the services. Some clients will want to have a private session with the marriage counsel therapist who will provide some of the solutions that affect the marriage of the client. There are those who will want to go to the marriage counseling therapist so that they can some hep when they are together of which it will be necessary for the clinic to respect their choices.
For an individual to get the best clinic, they will need to use some of the following methods that will give them the opportunity of getting the best services, An individual can get some recommendations or even referrals from some of their friends who may know the best clinics that offer the marriage counselling services. Such a friend will provide the relevant information about the clinic which will help an individual get him or herself ready for the session as well as the budget for the meetings.
Another way that an individual will get the best clinic is through the use of the internet as most of the clinics have websites where an individual can read more about the services they offer. An individual will have several choices of marriage counseling services that they will get from the various search engines. It will still be an easy option for an individual to make some comparison of the clinics as they will have all the information they need about the clinic on the online platform.
For instance, an individual can get some quotes for the marriage counseling services from the different clinic through the internet which will make it easy for an individual to choose the best that is within their budget. The websites will also have contact information which will help in getting some customer services among other information required for an individual to get satisfactory services.
If you are looking for a way to upgrade your business in relation to technology and to offer the best services to your clients, then you should definitely try to implement direct store delivery software. With direct store delivery, a company will effectively oversee the production of products, their storage, shipping and their delivery. Many manufacturers are adopting this form of managing products due to the various benefits that come with its use such as reduction of losses commonly caused by inventory loss. DSD is, however, a complicated process whose management can be hard without the use of third party companies. Fortunately, there is development of DSD software such as Harvest Food Solutions that enable companies to manage this complex aspects of their businesses with ease. The following are some of the factors that you will need to consider when implementing these software in your business.
To implement DSD in your business with the least setbacks, there is a lot more to be done. To achieve the best results from this process, you should choose the best DSD software for your business. There are negative side effects of choosing the wrong software solution such as technical problems and breaks in operation due to problems with the software you are using. Ensure that you choose software that has received positive online reviews and testimonials on the internet. Before choosing the DSD software solution for your company, ensure that you assess the credibility of its publisher in terms of experience. An experienced publisher will have had enough time to fix bugs and include better features to the software and is therefore a safer option in this selection process.
When choosing a DSD software solution, it is important to factor in the costs you will incur to buy the software and also the technical support that the publisher offers for the product. Be ready to invest in the best software for this process since there is a guarantee of a return on investment. With technical support, you will be able to avoid damages to both your image as a business and the loss that might occur if the software develops issues.


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Sha's Oiled Boobs Show
Sha likes to dress to show off her ultra-rare, amazing figure. Only a few girls are as super-slim and naturally big-busted as Sha. Valory Irene, Venera and Merilyn Sakova are in this league.
In this pictorial and matching video, Sha couldn't have picked a tighter tank top and Daisy Dukes.
"Men love my big boobs, and I like how my breasts look in pretty clothing," she says. "I like that I have big boobs and a thin waist. It is a lot of fun and it looks nice."
Maybe one day, Sha can get over to the States, but until then, we'll head over the Atlantic to photograph her every chance we get. Besides her incredible bod, Sha is one of the most-beautiful girls in any category of modeling.
Sha was the covergirl of the August and November '13 issues of SCORE.
"It was very exciting," Sha said. "I loved being on the cover. It was very flattering to be on the cover and to read the nice things people said about me."
Bound For Glory
Wet Tee Teasers

redpajama_set_name: RedPajamaCommonCrawl


(CNS): A local woman appeared in Grand Court Thursday charged with throwing a plant pot at her ex-husband's car over a custody dispute in April last year and causing damages of over CI$6,700. Ava Glasgow's former husband, Rohan Webster, claims that she came to his home where he and his current wife their children, including Glasgow's daughter, were home asleep. When he woke up and opened the door, after she had been banging loudly, he saw her throw the plant at the windshield of the Honda Accord parked in his driveway. Glasgow denies the allegations and says it was her aggressive and controlling former spouse who threw the plant to set her up.
She claimed she left her home in Crewe Road at around midnight that night after she had spoken by phone with her daughter, who was living with Webster, her father, at the time in Savannah.
Glasgow said her daughter was in distress and she had called the police, but they said it could wait until the next day. She disagreed, she said, and planned to walk there because she really believed her daughter needed her.
As she walked past Country & Western bar, she was given a ride by a stranger, who took her to Savannah. Glasgow claims that when she arrived at the house the lights were on, but when she knocked on the door they were all turned off.
She knocked for a short while but did not receive any response. She said that as she turned to leave, her ex-husband opened the door and came out, so she turned back around and walked towards him. Webster then picked up the pot and she expected him to throw it at her, Glasgow said, but instead he smiled and threw it at the car.
Glasgow claims she yelled that he was crazy and left the scene. She said it was not the first time he had falsely accused her of damaging his car, though she admitted to previously damaging his wife's car.
Webster claimed that Glasgow often caused scenes, while she claimed he was trying to prevent her from seeing their daughter at the time due to a protracted and antagonistic custody dispute.
The case was heard yesterday by a jury of four men and three women and presided over by Justice Michael Mettyear, who is expected to sum up the short case ahead of their deliberations Friday. Although the charge of damage to property does not carry a custodial sentence, the value of the damage enabled Glasgow to be tried in the Grand Court with a jury.


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But does that make it better or worse?
Pity percent.
It doesn't reflect on LN at all. Attempting to read into is...
Let's move on. Having to almost defend LN is leaving a bad taste in my mouth.
Reactions: Cordwainer Fish, monsmord and Deset Gled
I will agree that it's probably just a quirk in the way Facebook handles things. I should also say that when I originally posted about this I just assumed there were easy ways for companies to control their own Facebook polls. Whether by just paying Facebook off or some third party add-on tool, I generally assume that any poll I see on Facebook shows me what the company wants me to see (or that they didn't pay enough money to control it). Word from others like @Morrus make it sound like this is harder than I thought, and I trust them because I have very little direct experience with it.
That being said, here's the current results:
I don't know if there's any way to see who actually voted for Lanasa in the poll, but going by pure math (31*0.12) he got 3.72 votes. So, with rounding, either 3 or 4.
The real sad part? Lanasa controls at least 4 public FB accounts himself (TSR, DHSM, TSR Con, plus his personal). Plus there are accounts from his spouse, his father, Ernie, and the multiple accounts controlled by Dave Johnson and Michael Yach. And that's not even getting into the ones that are suspected alts of Lanasa himself. I don't know if corporate accounts like TSR Con could cast a vote, but even if they can't he should be able to come up with a minimum of 6 just from people we know (and probably closer to 12 with alts). A count of 3~4 implies he couldn't even get his friends and family to back him up on this. He literally posted more "shares" of this poll in other groups than he has votes.
It's not 'harder', it's impossible unless you're literally hacking Facebook somehow. You can't pay FB to change poll results.
The greater point is, who cares? This seems like a really minor thing to spend time and energy on. Him living rent free head space and all that. YMMV of course.
Reactions: Ancalagon, Audiomancer, Cordwainer Fish and 1 other person
But why are all the options phrased as questions?
For the record, based on a very cursory Google search, Eddie Radmayne appears to have the highest net worth, at $15 million.
Reactions: Gradine
Answer LaNasa so they can do a discovery of his revenue in court.
It depends I guess on what his actual plan here is. It may be that he wants people to say Cocks has the greater net worth so he push the David and Goliath narrative.
Reactions: MNblockhead
Please don't give them that idea...
If you're involved in litigation that could end up stripping you of your assets, is it such a good idea to be boasting online about your net worth?
Reactions: soviet, Dannyalcatraz and J.Quondam
Dioltach said:
Maybe he's trying to intimidate the opposition with his vast hoards of wealth and whatever?
I think it might be the opposite, actually. I think he's trying to play the "Well, of course the Hasbro CEO is worth more than me. I'm just a poor little gamer doing his best to get by, shucks and so forth."
Reactions: MNblockhead, Mannahnin and monsmord
It depends I guess on what his actual plan here is.
So far, three different people on the Anti-nuTSR Star Frontiers FB group have reported that they were blocked by the DHSM account after they voted for someone other than Lanasa. It's entirely possible the only purpose of the poll is to weed out people Lanasa doesn't like.
On an semi-related note, Victor Dorso (the guy who runs DaveCon) recently reported that Ernie no longer has control of the nuTSR FB pages. Lanasa changed the passwords and Ernie doesn't have the new ones. Ernie has been active on social media lately talking about the WotC OGL debacle and other things, but hasn't shared this info himself. So it's still hearsay at this point, but very interesting hearsay.
Reactions: Ancalagon, MNblockhead, Dannyalcatraz and 3 others
Because he can neither write nor proofread.
Reactions: MNblockhead, Davies and Cordwainer Fish
tenkar
Old School Blogger
LaNasa had to attest in federal court that he had sole control over the DHSM and TSR social media accounts. He attested to such, and I suspect Ernie was shut down at that point.
MNblockhead
A Title Much Cooler Than Anything on the Old Site
Oh, they don't need a Facebook poll to do that. Best to just ignore the poll and not engage with whatever he's up to.
Reactions: Faolyn
MNblockhead said:
Can't argue with that sound advice, but that would probably also mean we wouldn't have this thread in the first place.
No, please don't say that. There is only so much I can read about the OGL!
Reactions: bitjunkie, Ondath, Azzy and 6 others
Well, NuTSR promised an update on their poll by January 21st. In true NuTSR fashion, they have failed to deliver. Here's the current status of the poll:
Note Eddie Redmayne and Luke Gygax have been removed. There were more than 36 votes total, but some were removed when those two individuals were taken out. Still only 3~4 for Lanasa.
So what was NuTSR up to over the weekend that kept them from following up as promised? Lanasa was busy reliving his glory days as a failed weapons designer. I guess he needed a break from being a failed publisher. He posted these pics, which are from the Shot Show convention in 2015:
The shirt comes from a company called "November Fire": War Is Hell Shirts Page 1
More updates in a few minutes.


Do not see interviews as the chance, think it as an opportunity to present you to a company. It is a chance for you to prove yourself in front of the interviewer, so you should come with full preparation of questions you need answers.
You can search for the company profile. Also gather the latest information on that company. If want all information about the company then a good option is to check their website which may have more background information. If you want to do well at the interview, you will need to convince the interviewer that you are technically qualified to do the job.
The job interview tips covers most job interview tips and also covers lots of things which we have to avoid during interview.
Here are some Do's and Don'ts while interview.
Take a spare photo and CV with you!


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MainAll NewsEuropeReport: Anti-Semitism on the rise in Czech Republic
Report: Anti-Semitism on the rise in Czech Republic
Report released by Czech Jewish community finds anti-Semitic incidents increased in the country last year.
Nissan Tzur, 04/07/19 05:00
Anti-Semitism in Europe (archive)
Photo by TPS
The Jewish community in the Czech Republic released a report on Wednesday which found there was an increase in the number of anti-Semitic incidents in the country last year.
In the report, cited by The Associated Press, the Federation of the Jewish Communities said there were 347 anti-Semitic attacks in 2018, up by 221 from 2015 when the last equivalent report was published.
Most of the attacks — 93% — appeared on the internet, often on far-right, anti-liberal and pro-Russian media, the report found.
The group said there were two physical attacks and three attacks on Jewish property last year. The remainder involved anti-Semitic threats, harassment and verbal abuse.
The report noted, however, that the Czech Republic remains a safe country for Jews and anti-Semitism is at a relatively low level compared with other European countries.
The lower house of the Czech Parliament earlier this year recognized the International Holocaust Remembrance Alliance (IHRA) definition of anti-Semitism.
The definition includes classic forms of anti-Semitism, but also offers examples of modern manifestations, such as targeting all Jews as a proxy for Israel, denying Jews the right to a homeland and using historical anti-Semitic images to tarnish all Israelis.
Tags:Anti-Semitism, Czech republic


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The Raymarine A Series range combines all the technology and performance of Raymarine's multifunction displays into one brand new and compact unit.
The series is available in three screen sizes and a range comprising two chartplotters and three chartplotter/fishfinder combinations — the A50, A50D, A57D, A70 and A70D.
The units feature a direct sunlight-viewable high resolution VGA colour display. They are made from rugged and waterproof material that makes them suitable for centre-consoles and open cockpits. They come with a one-size quick-release tilt and swivel bracket that allows for easy installation, and they can be easily removed, so you can take it with you.
The A Series offers users multiple options based around Raymarine's core fishfinder and chartplotter system that accepts input from communication and safety products including AIS, DSC, engine monitoring and data, and autopilot interface using Raymarine's SeaTalk NG/NMEA2000 inputs.
Keen fishos will also find that Raymarine's patented HD Digital fishfinding technology is easily accessible on the D–suffixed units. The digital sounder module is enclosed within the product itself, leaving only the power cable and a depth/speed/temperature triducer to be plugged in.


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Q: Generate a chm file from a html directory I'm looking for a Windows tool to generate a chm file from a bunch of HTML files... any recommendations?

A: Check out the HTML Help Workshop and some associated docs.

redpajama_set_name: RedPajamaStackExchange


Up to this point, I have discussed access control abstractly, mostly as a discussion about what happens inside an EHR. The implementation of access control within an EHR is an essential task in healthcare because it involves a patient. I will now cover how to extend access control to an HIE.31 An HIE is simply an extension of the healthcare information across organizational boundaries usually within a region, community, or beyond. The patient or employee may have healthcare coverage in many geographic areas.


We are delighted to present authors Violet Wadrill, Biddy Wavehill, Topsy Ngarnjal and Felicity Meakins for a special presentation of their bi-lingual book, Karu: Growing up Gurindji. This fascinating book is about Indigenous childrearing practices, both spiritual as well as the pragmatic, but always deeply embedded in an understanding of country and family connections. Karu: Growing up Gurindji celebrates children growing up Gurindji, and honours those Gurindji mothers, grandmothers, assistant teachers and health workers who dedicate their lives to making that possible.
Image: Cover image from Karu: Growing up Gurindji (Violet Wadrill, Topsy Dodd, Biddy Wavehill and Felicity Meakins, Spinifex Press, 2019) by Chloe Algy and Becky Peter showing kupuwupu 'lemon grass' from Cattle Creek Station in 2010.


JC Phelan, owner of Jack Phelan Chevrolet & Jack Phelan Dodge Chrysler Jeep Ram, was elected to join the Chicago Automobile Trade Association (CATA) board of directors this June.
Phelan brings 15 years of professional experience to the CATA board of directors and has overseen operations at the Dodge Chrysler Jeep Ram store since 2009. Phelan is a member of the local Chevrolet marking association and a Nazareth Academy graduate and has a bachelor's degree from Benedictine University.


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Illustration by Jason Reed
The icy history of the 'apply cold water to burn' meme
This is going to sting.
Grant Pardee
Published Mar 22, 2017 Updated May 24, 2021, 8:01 pm CDT
The first thing you should do when you accidentally burn yourself—whether it's by touching a hot curling iron or brushing up against scalding kitchen pan—is to apply cold water. It helps numb the pain and limits the extent of the damage.
And the first thing you should do when you see someone get burned on the internet, of course, is to share the "apply cold water to burned area" meme. There's no better or faster way of reiterating that someone got thoroughly owned than by posting some variation of the familiar image macro.
Image via Know Your Meme
How did this idea originate, and when did it become a meme?
It's become common parlance for disparaging jokes to be known as "burns." The first example of a mean joke being equated to something fiery dates back to 1950, when the Friars Club in New York City held its first-ever "roast," called such because it was the opposite of a "toast" or celebration. The idea of roasting friends became especially popular after the Friars Club began televising the events in the 1960s. Today, of course, they continue on in the form of the Comedy Central Roasts.
https://www.youtube.com/watch?v=wJzL7ixtPjc
The slang of "burn" grew in the 1970s as a result of the roasts. In the early 2000s, the phrase re-emerged due to Ashton Kutcher's character repeatedly using it on That '70s Show.
GIF via Giphy
In fact, the word was added to Urban Dictionary in 2002 and gradually grew in popularity until it earned Word of the Day in 2005. Since then, "burn" has been a permanent fixture in the public lexicon.
So who was the clever person to introduce "cold water" to the phrase? According to KnowYourMeme, the burn meme first appeared May 12, 2012, in a FunnyJunk post by user oodlesandoodles with the accompanying text: "Hope they remembered to pour some cool water on that burn."
However, the first truly viral meme version came two days later, when the burn treatment response image was instead paired with this screenshot:
Photo via Imgur
The image was reposted to Reddit, 9gag, and The Lolbrary, rapidly spreading the meme. Since then, the "apply cold water" image has been paired with countless instances of "burn" examples.
The full phrase entered Urban Dictionary in 2013, with a definition provided by user "AsianInfestation":
"When someone burns you, or you burn someone, some obnoxious person in the back would yell "APPLY COLD WATER TO BURNED AREA!" Because naturally, you or the other person just got burned… See roast or roasted . It's basically just a stupid little statement to say to someone who just got burned by another person."
Today, the meme is commonly used across every social hub on the internet. Searching the phrase yields results on every platform from Tumblr to DeviantArt to Imgur. On Facebook, for example, dozens of groups are dedicated to providing examples of burns in need of cold water, with the largest having over 18,000 likes. Wherever people are mean on the internet, you can be sure this meme won't be far behind.
Screengrab via Google Trends
Here are just a few of our favorite examples:
Screengrab via Tickld/Pinterest
May you never be burned in such a way that you need cold water.
*First Published: Mar 22, 2017, 4:00 am CDT
Grant Pardee is a writer and producer specializing in digital video, social media, and web culture reporting. He has produced videos for Fullscreen, SourceFed, and Funny or Die, and his work has been published by Vice, McSweeney's, and Rooster Teeth.


text:
CPC Plans Response to Final USDA COOL Regulation
5 November 2003, at 12:00am
CANADA - Farm-Scape: Episode 1378. Farm-Scape is a Wonderworks Canada production and is distributed courtesy of Manitoba Pork Council and Sask Pork.
Farm-Scape is sponsored by
Manitoba Pork Council and Sask Pork
Farm-Scape is a Wonderworks Canada production and is distributed courtesy of Manitoba Pork Council
and Sask Pork.
Farm-Scape, Episode 1378
The Canadian Pork Council says it will issue an official response, by the end of next month, to the release of a proposed final US Country of Origin Labelling regulation.
US Country of Origin Labelling, under which red meats, fish, perishable agricultural commodities and peanuts will be required to be labelled according to where it comes from, is due to become mandatory in September 2004.
Last week the US Department of Agriculture released its proposed final regulation.
Canadian Pork Council Executive Director Martin Rice says, as earlier feared by players within the US industry as well groups involved in exporting to the US, this will represent a significant cost to the red meat industry.
"The USDA is staying with its earlier interpretation that this law will require very significant record keeping efforts on the part of all players in the distribution chain.
Retailers will be required to demonstrate how they know what country this is coming from. That, in turn, implies a lot of record keeping on the part of all of their suppliers not just the importers but their domestic suppliers as well.
We will take advantage of opportunities to provide input to the US Department of Agriculture on the disadvantages that this law imposes not only for Canadian exporters but for US meat industry participants.
The comment period is 60 days so, toward the end of December, we will be putting in views which I believe will be similar to those we put in earlier cases.
As I mentioned, the regulation looks very similar to what USDA has put out before".
Rice says the USDA has made it clear that it doesn't see room for much latitude on this matter and that it will need to be looking for very substantial record keeping and other compliance requirements.
For Farmscape.Ca, I'm Bruce Cochrane.


We create value through our interactions with the world, whether it's our work, the way we spend money, or our family life. This blog is an exploration of those interactions and the small and large ways in which we impact that which surrounds us. Value is both tangible and intangible, it can be material, or hard to grasp. Most often, it's whatever we decide it is.
And we create value when we do silly things too.


text:
Displaying 1 - 10 of 35. Show 10 | 20 results per page.
Project acronym A-DATADRIVE-B
Project Advanced Data-Driven Black-box modelling
Researcher (PI) Johan Adelia K Suykens
Summary Making accurate predictions is a crucial factor in many systems (such as in modelling energy consumption, power load forecasting, traffic networks, process industry, environmental modelling, biomedicine, brain-machine interfaces) for cost savings, efficiency, health, safety and organizational purposes. In this proposal we aim at realizing a new generation of more advanced black-box modelling techniques for estimating predictive models from measured data. We will study different optimization modelling frameworks in order to obtain improved black-box modelling approaches. This will be done by specifying models through constrained optimization problems by studying different candidate core models (parametric models, support vector machines and kernel methods) together with additional sets of constraints and regularization mechanisms. Different candidate mathematical frameworks will be considered with models that possess primal and (Lagrange) dual model representations, functional analysis in reproducing kernel Hilbert spaces, operator splitting and optimization in Banach spaces. Several aspects that are relevant to black-box models will be studied including incorporation of prior knowledge, structured dynamical systems, tensorial data representations, interpretability and sparsity, and general purpose optimization algorithms. The methods should be suitable for handling larger data sets and high dimensional input spaces. The final goal is also to realize a next generation software tool (including symbolic generation of models and handling different supervised and unsupervised learning tasks, static and dynamic systems) that can be generically applied to data from different application areas. The proposal A-DATADRIVE-B aims at getting end-users connected to the more advanced methods through a user-friendly data-driven black-box modelling tool. The methods and tool will be tested in connection to several real-life applications.
Making accurate predictions is a crucial factor in many systems (such as in modelling energy consumption, power load forecasting, traffic networks, process industry, environmental modelling, biomedicine, brain-machine interfaces) for cost savings, efficiency, health, safety and organizational purposes. In this proposal we aim at realizing a new generation of more advanced black-box modelling techniques for estimating predictive models from measured data. We will study different optimization modelling frameworks in order to obtain improved black-box modelling approaches. This will be done by specifying models through constrained optimization problems by studying different candidate core models (parametric models, support vector machines and kernel methods) together with additional sets of constraints and regularization mechanisms. Different candidate mathematical frameworks will be considered with models that possess primal and (Lagrange) dual model representations, functional analysis in reproducing kernel Hilbert spaces, operator splitting and optimization in Banach spaces. Several aspects that are relevant to black-box models will be studied including incorporation of prior knowledge, structured dynamical systems, tensorial data representations, interpretability and sparsity, and general purpose optimization algorithms. The methods should be suitable for handling larger data sets and high dimensional input spaces. The final goal is also to realize a next generation software tool (including symbolic generation of models and handling different supervised and unsupervised learning tasks, static and dynamic systems) that can be generically applied to data from different application areas. The proposal A-DATADRIVE-B aims at getting end-users connected to the more advanced methods through a user-friendly data-driven black-box modelling tool. The methods and tool will be tested in connection to several real-life applications.
Project acronym BRIDGE
Project Biomimetic process design for tissue regeneration: from bench to bedside via in silico modelling
Researcher (PI) Liesbet Geris
Host Institution (HI) UNIVERSITE DE LIEGE
Summary "Tissue engineering (TE), the interdisciplinary field combining biomedical and engineering sciences in the search for functional man-made organ replacements, has key issues with the quantity and quality of the generated products. Protocols followed in the lab are mainly trial and error based, requiring a huge amount of manual interventions and lacking clear early time-point quality criteria to guide the process. As a result, these processes are very hard to scale up to industrial production levels. BRIDGE aims to fortify the engineering aspects of the TE field by adding a higher level of understanding and control to the manufacturing process (MP) through the use of in silico models. BRIDGE will focus on the bone TE field to provide proof of concept for its in silico approach. The combination of the applicant's well-received published and ongoing work on a wide range of modelling tools in the bone field combined with the state-of-the-art experimental techniques present in the TE lab of the additional participant allows envisaging following innovation and impact: 1. proof-of-concept of the use of an in silico blue-print for the design and control of a robust modular TE MP; 2. model-derived optimised culture conditions for patient derived cell populations increasing modular robustness of in vitro chondrogenesis/endochondral ossification; 3. in silico identification of a limited set of in vitro biomarkers that is predictive of the in vivo outcome; 4. model-derived optimised culture conditions increasing quantity and quality of the in vivo outcome of the TE MP; 5. incorporation of congenital defects in the in silico MP design, constituting a further validation of BRIDGE's in silico approach and a necessary step towards personalised medical care. We believe that the systematic – and unprecedented – integration of (bone) TE and mathematical modelling, as proposed in BRIDGE, is required to come to a rationalized, engineering approach to design and control bone TE MPs."
"Tissue engineering (TE), the interdisciplinary field combining biomedical and engineering sciences in the search for functional man-made organ replacements, has key issues with the quantity and quality of the generated products. Protocols followed in the lab are mainly trial and error based, requiring a huge amount of manual interventions and lacking clear early time-point quality criteria to guide the process. As a result, these processes are very hard to scale up to industrial production levels. BRIDGE aims to fortify the engineering aspects of the TE field by adding a higher level of understanding and control to the manufacturing process (MP) through the use of in silico models. BRIDGE will focus on the bone TE field to provide proof of concept for its in silico approach. The combination of the applicant's well-received published and ongoing work on a wide range of modelling tools in the bone field combined with the state-of-the-art experimental techniques present in the TE lab of the additional participant allows envisaging following innovation and impact: 1. proof-of-concept of the use of an in silico blue-print for the design and control of a robust modular TE MP; 2. model-derived optimised culture conditions for patient derived cell populations increasing modular robustness of in vitro chondrogenesis/endochondral ossification; 3. in silico identification of a limited set of in vitro biomarkers that is predictive of the in vivo outcome; 4. model-derived optimised culture conditions increasing quantity and quality of the in vivo outcome of the TE MP; 5. incorporation of congenital defects in the in silico MP design, constituting a further validation of BRIDGE's in silico approach and a necessary step towards personalised medical care. We believe that the systematic – and unprecedented – integration of (bone) TE and mathematical modelling, as proposed in BRIDGE, is required to come to a rationalized, engineering approach to design and control bone TE MPs."
Project acronym CAAXPROCESSINGHUMDIS
Project CAAX Protein Processing in Human DIsease: From Cancer to Progeria
Researcher (PI) Martin Olof Bergö
Host Institution (HI) GOETEBORGS UNIVERSITET
Summary My objective is to understand the physiologic and medical importance of the posttranslational processing of CAAX proteins (e.g., K-RAS and prelamin A) and to define the suitability of the CAAX protein processing enzymes as therapeutic targets for the treatment of cancer and progeria. CAAX proteins undergo three posttranslational processing steps at a carboxyl-terminal CAAX motif. These processing steps, which are mediated by four different enzymes (FTase, GGTase-I, RCE1, and ICMT), increase the hydrophobicity of the carboxyl terminus of the protein and thereby facilitate interactions with membrane surfaces. Somatic mutations in K-RAS deregulate cell growth and are etiologically involved in the pathogenesis of many forms of cancer. A mutation in prelamin A causes Hutchinson-Gilford progeria syndrome—a pediatric progeroid syndrome associated with misshaped cell nuclei and a host of aging-like disease phenotypes. One strategy to render the mutant K-RAS and prelamin A less harmful is to interfere with their ability to bind to membrane surfaces (e.g., the plasma membrane and the nuclear envelope). This could be accomplished by inhibiting the enzymes that modify the CAAX motif. My Specific Aims are: (1) To define the suitability of the CAAX processing enzymes as therapeutic targets in the treatment of K-RAS-induced lung cancer and leukemia; and (2) To test the hypothesis that inactivation of FTase or ICMT will ameliorate disease phenotypes of progeria. I have developed genetic strategies to produce lung cancer or leukemia in mice by activating an oncogenic K-RAS and simultaneously inactivating different CAAX processing enzymes. I will also inactivate several CAAX processing enzymes in mice with progeria—both before the emergence of phenotypes and after the development of advanced disease phenotypes. These experiments should reveal whether the absence of the different CAAX processing enzymes affects the onset, progression, or regression of cancer and progeria.
My objective is to understand the physiologic and medical importance of the posttranslational processing of CAAX proteins (e.g., K-RAS and prelamin A) and to define the suitability of the CAAX protein processing enzymes as therapeutic targets for the treatment of cancer and progeria. CAAX proteins undergo three posttranslational processing steps at a carboxyl-terminal CAAX motif. These processing steps, which are mediated by four different enzymes (FTase, GGTase-I, RCE1, and ICMT), increase the hydrophobicity of the carboxyl terminus of the protein and thereby facilitate interactions with membrane surfaces. Somatic mutations in K-RAS deregulate cell growth and are etiologically involved in the pathogenesis of many forms of cancer. A mutation in prelamin A causes Hutchinson-Gilford progeria syndrome—a pediatric progeroid syndrome associated with misshaped cell nuclei and a host of aging-like disease phenotypes. One strategy to render the mutant K-RAS and prelamin A less harmful is to interfere with their ability to bind to membrane surfaces (e.g., the plasma membrane and the nuclear envelope). This could be accomplished by inhibiting the enzymes that modify the CAAX motif. My Specific Aims are: (1) To define the suitability of the CAAX processing enzymes as therapeutic targets in the treatment of K-RAS-induced lung cancer and leukemia; and (2) To test the hypothesis that inactivation of FTase or ICMT will ameliorate disease phenotypes of progeria. I have developed genetic strategies to produce lung cancer or leukemia in mice by activating an oncogenic K-RAS and simultaneously inactivating different CAAX processing enzymes. I will also inactivate several CAAX processing enzymes in mice with progeria—both before the emergence of phenotypes and after the development of advanced disease phenotypes. These experiments should reveal whether the absence of the different CAAX processing enzymes affects the onset, progression, or regression of cancer and progeria.
Project acronym CANCERSTEM
Project Stem cells in epithelial cancer initiation and growth
Researcher (PI) Cédric Blanpain
Host Institution (HI) UNIVERSITE LIBRE DE BRUXELLES
Summary Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes. For most cancers, the target cells of oncogenic mutations are unknown. Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation. Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumor upon transplantation. However, whether the initial oncogenic mutations arise in normal stem cells or in more differentiated cells that re-acquire stem cell-like properties remains to be determined. The demonstration that SCs are the target cells of the initial transforming events and that cancers contain cells with SC characteristics await the development of tools allowing for the isolation and characterization of normal adult SCs. In most epithelia from which cancers naturally arise, such tools are not yet available. We have recently developed novel methods to specifically mark and isolate multipotent epidermal slow-cycling SCs, making it now possible to determine the role of SC during epithelial cancer formation. In this project, we will use mice epidermis as a model to define the role of SC in epithelial cancer initiation and growth. Specifically, we will determine whether epithelial SCs are the initial target cells of oncogenic mutations during skin cancer formation, whether oncogenic mutations lead preferentially to skin cancer when they arise in SC rather than in more committed cells and whether cancer stem cells contribute to epithelial tumor growth and relapse after therapy.
Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes. For most cancers, the target cells of oncogenic mutations are unknown. Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation. Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumor upon transplantation. However, whether the initial oncogenic mutations arise in normal stem cells or in more differentiated cells that re-acquire stem cell-like properties remains to be determined. The demonstration that SCs are the target cells of the initial transforming events and that cancers contain cells with SC characteristics await the development of tools allowing for the isolation and characterization of normal adult SCs. In most epithelia from which cancers naturally arise, such tools are not yet available. We have recently developed novel methods to specifically mark and isolate multipotent epidermal slow-cycling SCs, making it now possible to determine the role of SC during epithelial cancer formation. In this project, we will use mice epidermis as a model to define the role of SC in epithelial cancer initiation and growth. Specifically, we will determine whether epithelial SCs are the initial target cells of oncogenic mutations during skin cancer formation, whether oncogenic mutations lead preferentially to skin cancer when they arise in SC rather than in more committed cells and whether cancer stem cells contribute to epithelial tumor growth and relapse after therapy.
Project acronym CAPCAN
Project Molecular and Genetic Study of the human infections by Capnocytophaga canimorsus
Researcher (PI) Guy Richard Cornelis
Summary "Capnocytophaga canimorsus are Gram-negative bacteria from the normal oral flora of dogs, which cause rare but severe infections in humans that have been bitten or simply licked. The most common syndrome is fulminant septicemia with peripheral gangrene. Mortality reaches 40 % in spite of antibiotherapy and amputations. My laboratory pioneered recently the study of this new pathogen. We engineered genetic tools, sequenced and annotated the genome and determined the surface proteome of a strain isolated from a fatal infection. This showed that C. canimorsus have abundant surface-exposed lipoproteins forming a new kind of feeding complexes, some of them specialized in deglycosylating glycoproteins from the host. This property allows C. canimorsus to feed by grazing oligosaccharides at the surface of human cells. The present research program aims at characterizing these deglycosylating complexes, unravelling their role in neutralizing the innate immunity and promoting growth within the host and finally characterizing their assembly at the bacterial surface. Genomic comparisons will help defining which of these many complexes play a critical role in human pathogenesis. Besides this, the lipopolysaccharide structure will be determined and genetically manipulated to understand its low endotoxicity and small anti-inflammatory effectors present in the culture supernatant of C. canimorsus will be identified. Growth in human blood of wild type and mutant strains will be monitored by isothermal microcalorimetry in the hope of developing a surrogate of animal model. Such a ""virulence"" model would allow to address the question whether all dog's strains are equally dangerous for humans. It would also open an avenue for testing differences in individual human susceptibility. All this knowledge will give new insights in this emerging pathogen and might lead to prevention of the disease caused by C. canimorsus"
"Capnocytophaga canimorsus are Gram-negative bacteria from the normal oral flora of dogs, which cause rare but severe infections in humans that have been bitten or simply licked. The most common syndrome is fulminant septicemia with peripheral gangrene. Mortality reaches 40 % in spite of antibiotherapy and amputations. My laboratory pioneered recently the study of this new pathogen. We engineered genetic tools, sequenced and annotated the genome and determined the surface proteome of a strain isolated from a fatal infection. This showed that C. canimorsus have abundant surface-exposed lipoproteins forming a new kind of feeding complexes, some of them specialized in deglycosylating glycoproteins from the host. This property allows C. canimorsus to feed by grazing oligosaccharides at the surface of human cells. The present research program aims at characterizing these deglycosylating complexes, unravelling their role in neutralizing the innate immunity and promoting growth within the host and finally characterizing their assembly at the bacterial surface. Genomic comparisons will help defining which of these many complexes play a critical role in human pathogenesis. Besides this, the lipopolysaccharide structure will be determined and genetically manipulated to understand its low endotoxicity and small anti-inflammatory effectors present in the culture supernatant of C. canimorsus will be identified. Growth in human blood of wild type and mutant strains will be monitored by isothermal microcalorimetry in the hope of developing a surrogate of animal model. Such a ""virulence"" model would allow to address the question whether all dog's strains are equally dangerous for humans. It would also open an avenue for testing differences in individual human susceptibility. All this knowledge will give new insights in this emerging pathogen and might lead to prevention of the disease caused by C. canimorsus"
Project acronym CRASH
Project CRyptographic Algorithms and Secure Hardware
Researcher (PI) François-Xavier Standaert
Host Institution (HI) UNIVERSITE CATHOLIQUE DE LOUVAIN
Summary Side-channel attacks are an important threat against cryptographic implementations in which an adversary takes advantage of physical leakages, such as the power consumption of a smart card, in order to recover secret information. By circumventing the models in which standard security proofs are obtained, they can lead to powerful attacks against a large class of devices. As a consequence, formalizing implementation security and efficiently preventing side-channel attacks is one of the most challenging open problems in modern cryptography. Physical attacks imply new optimization criteria, with potential impact on the way we conceive algorithms and the way we design circuits. By putting together mathematical and electrical engineering problems, just as they are raised in reality, the CRASH project is expected to develop concrete basements for the next generation of cryptographic algorithms and their implementation. For this purpose, three main directions will be considered. First, we will investigate sound evaluation tools for side-channel attacks and validate them on different prototype chips. Second, we will consider the impact of physical attacks on the mathematical aspects of cryptography, both destructively (i.e. by developing new attacks and advanced cryptanalysis tools) and constructively (i.e. by investigating new cipher designs and security proof techniques). Third, we will evaluate the possibility to integrate physical security analysis into the design tools of integrated circuits (e.g. in order to obtain "physical security aware" compilers). Summarizing, this project aims to break the barrier between the abstractions of mathematical cryptography and the concrete peculiarities of physical security in present microelectronic devices. By considering the system and algorithmic issues in a unified way, it is expected to get rid of the incompatibilities between the separate formalisms that are usually considered in order to explain these concurrent realities.
Side-channel attacks are an important threat against cryptographic implementations in which an adversary takes advantage of physical leakages, such as the power consumption of a smart card, in order to recover secret information. By circumventing the models in which standard security proofs are obtained, they can lead to powerful attacks against a large class of devices. As a consequence, formalizing implementation security and efficiently preventing side-channel attacks is one of the most challenging open problems in modern cryptography. Physical attacks imply new optimization criteria, with potential impact on the way we conceive algorithms and the way we design circuits. By putting together mathematical and electrical engineering problems, just as they are raised in reality, the CRASH project is expected to develop concrete basements for the next generation of cryptographic algorithms and their implementation. For this purpose, three main directions will be considered. First, we will investigate sound evaluation tools for side-channel attacks and validate them on different prototype chips. Second, we will consider the impact of physical attacks on the mathematical aspects of cryptography, both destructively (i.e. by developing new attacks and advanced cryptanalysis tools) and constructively (i.e. by investigating new cipher designs and security proof techniques). Third, we will evaluate the possibility to integrate physical security analysis into the design tools of integrated circuits (e.g. in order to obtain "physical security aware" compilers). Summarizing, this project aims to break the barrier between the abstractions of mathematical cryptography and the concrete peculiarities of physical security in present microelectronic devices. By considering the system and algorithmic issues in a unified way, it is expected to get rid of the incompatibilities between the separate formalisms that are usually considered in order to explain these concurrent realities.
Project acronym ERIKLINDAHLERC2007
Project Multiscale and Distributed Computing Algorithms for Biomolecular Simulation and Efficient Free Energy Calculations
Researcher (PI) Erik Lindahl
Host Institution (HI) KUNGLIGA TEKNISKA HOEGSKOLAN
Summary The long-term goal of our research is to advance the state-of-the-art in molecular simulation algorithms by 4-5 orders of magnitude, particularly in the context of the GROMACS software we are developing. This is an immense challenge, but with huge potential rewards: it will be an amazing virtual microscope for basic chemistry, polymer and material science research; it could help us understand the molecular basis of diseases such as Creutzfeldt-Jacob, and it would enable rational design rather than random screening for future drugs. To realize it, we will focus on four critical topics: • ALGORITHMS FOR SIMULATION ON GRAPHICS AND OTHER STREAMING PROCESSORS: Graphics cards and the test Intel 80-core chip are not only the most powerful processors available, but this type of streaming architectures will power many supercomputers in 3-5 years, and it is thus critical that we design new "streamable" MD algorithms. • MULTISCALE MODELING: We will develop virtual-site-based methods to bridge atomic and mesoscopic dynamics, QM/MM, and mixed explicit/implicit solvent models with water layers around macromolecules. • MULTI-LEVEL PARALLEL & DISTRIBUTED SIMULATION: Distributed computing provides virtually infinite computer power, but has been limited to small systems. We will address this by combining SMP parallelization and Markov State Models that partition phase space into transition/local dynamics to enable distributed simulation of arbitrary systems. • EFFICIENT FREE ENERGY CALCULATIONS: We will design algorithms for multi-conformational parallel sampling, implement Bennett Acceptance Ratios in Gromacs, correction terms for PME lattice sums, and combine standard force fields with polarization/multipoles, e.g. Amoeba. We have a very strong track record of converting methodological advances into applications, and the results will have impact on a wide range of fields from biomolecules and polymer science through material simulations and nanotechnology.
The long-term goal of our research is to advance the state-of-the-art in molecular simulation algorithms by 4-5 orders of magnitude, particularly in the context of the GROMACS software we are developing. This is an immense challenge, but with huge potential rewards: it will be an amazing virtual microscope for basic chemistry, polymer and material science research; it could help us understand the molecular basis of diseases such as Creutzfeldt-Jacob, and it would enable rational design rather than random screening for future drugs. To realize it, we will focus on four critical topics: • ALGORITHMS FOR SIMULATION ON GRAPHICS AND OTHER STREAMING PROCESSORS: Graphics cards and the test Intel 80-core chip are not only the most powerful processors available, but this type of streaming architectures will power many supercomputers in 3-5 years, and it is thus critical that we design new "streamable" MD algorithms. • MULTISCALE MODELING: We will develop virtual-site-based methods to bridge atomic and mesoscopic dynamics, QM/MM, and mixed explicit/implicit solvent models with water layers around macromolecules. • MULTI-LEVEL PARALLEL & DISTRIBUTED SIMULATION: Distributed computing provides virtually infinite computer power, but has been limited to small systems. We will address this by combining SMP parallelization and Markov State Models that partition phase space into transition/local dynamics to enable distributed simulation of arbitrary systems. • EFFICIENT FREE ENERGY CALCULATIONS: We will design algorithms for multi-conformational parallel sampling, implement Bennett Acceptance Ratios in Gromacs, correction terms for PME lattice sums, and combine standard force fields with polarization/multipoles, e.g. Amoeba. We have a very strong track record of converting methodological advances into applications, and the results will have impact on a wide range of fields from biomolecules and polymer science through material simulations and nanotechnology.
Project acronym FLEXBOT
Project Flexible object manipulation based on statistical learning and topological representations
Researcher (PI) Danica Kragic Jensfelt
Summary A vision for the future are autonomous and semi-autonomous systems that perform complex tasks safely and robustly in interaction with humans and the environment. The action of such a system needs to be carefully planned and executed, taking into account the available sensory feedback and knowledge about the environment. Many of the existing approaches view motion planning as a geometrical problem, not taking the uncertainty into account. Our goal is to study how different type of representations and algorithms from the area of machine learning and classical mathematics can be used to solve some of the open problems in the area of action recognition and action generation. FLEXBOT will explore how how topological representations can be used for an integrated approach toward i) vision based understanding of complex human hand motion, ii) mapping and control of robotics hands and iii) integrating the topological representations with models for high-level task encoding and planning. Our research opens for new and important areas scientifically and technologically. Scientifically, we push for new way of thinking in an area that has traditionally been born from mechanical modeling of bodies. Technologically, we will provide methods plausible for evaluation of new designs of robotic and prosthetic hands. Further development of machine learning and computer vision methods will allow for scene understanding that goes beyond the assumption of worlds of rigid bodies, including complex objects such as hands.
A vision for the future are autonomous and semi-autonomous systems that perform complex tasks safely and robustly in interaction with humans and the environment. The action of such a system needs to be carefully planned and executed, taking into account the available sensory feedback and knowledge about the environment. Many of the existing approaches view motion planning as a geometrical problem, not taking the uncertainty into account. Our goal is to study how different type of representations and algorithms from the area of machine learning and classical mathematics can be used to solve some of the open problems in the area of action recognition and action generation. FLEXBOT will explore how how topological representations can be used for an integrated approach toward i) vision based understanding of complex human hand motion, ii) mapping and control of robotics hands and iii) integrating the topological representations with models for high-level task encoding and planning. Our research opens for new and important areas scientifically and technologically. Scientifically, we push for new way of thinking in an area that has traditionally been born from mechanical modeling of bodies. Technologically, we will provide methods plausible for evaluation of new designs of robotic and prosthetic hands. Further development of machine learning and computer vision methods will allow for scene understanding that goes beyond the assumption of worlds of rigid bodies, including complex objects such as hands.
Project acronym FLUOROCODE
Project FLUOROCODE: a super-resolution optical map of DNA
Researcher (PI) Johan M. V. Hofkens
Summary "There has been an immense investment of time, effort and resources in the development of the technologies that enable DNA sequencing in the past 10 years. Despite the significant advances made, all of the current genomic sequencing technologies suffer from two important shortcomings. Firstly, sample preparation is time-consuming and expensive, and requiring a full day for sample preparation for next-generation sequencing experiments. Secondly, sequence information is delivered in short fragments, which are then assembled into a complete genome. Assembly is time-consuming and often results in a highly fragmented genomic sequence and the loss of important information on large-scale structural variation within the genome. We recently developed a super-resolution DNA mapping technology, which allows us to uniquely study genetic-scale features in genomic length DNA molecules. Labelling the DNA with fluorescent molecules at specific sequences and using high-resolution fluorescence microscopy enabled us to produce a map of a genomic DNA sequence with unparalleled resolution, the so called FLUOROCODE. In this project we aim to extend our methodology to map longer DNA molecules and to include a multi-colour version of the FLUOROCODE that will allow us to read genomic DNA molecules like a barcode and probe DNA methylation status. The sample preparation, DNA labelling and deposition for imaging will be integrated to allow rapid mapping of DNA molecules. At the same time nanopores will be explored as a route to high-throughput DNA mapping. FLUOROCODE will develop technology that aims to complement the information derived from current DNA sequencing platforms. The technology developed by FLUOROCODE will enable DNA mapping at unprecedented speed and for a fraction of the cost of a typical DNA sequencing project. We aniticipate that our method will find applications in the rapid identification of pathogens and in producing genomic scaffolds to improve genome sequence assembly."
"There has been an immense investment of time, effort and resources in the development of the technologies that enable DNA sequencing in the past 10 years. Despite the significant advances made, all of the current genomic sequencing technologies suffer from two important shortcomings. Firstly, sample preparation is time-consuming and expensive, and requiring a full day for sample preparation for next-generation sequencing experiments. Secondly, sequence information is delivered in short fragments, which are then assembled into a complete genome. Assembly is time-consuming and often results in a highly fragmented genomic sequence and the loss of important information on large-scale structural variation within the genome. We recently developed a super-resolution DNA mapping technology, which allows us to uniquely study genetic-scale features in genomic length DNA molecules. Labelling the DNA with fluorescent molecules at specific sequences and using high-resolution fluorescence microscopy enabled us to produce a map of a genomic DNA sequence with unparalleled resolution, the so called FLUOROCODE. In this project we aim to extend our methodology to map longer DNA molecules and to include a multi-colour version of the FLUOROCODE that will allow us to read genomic DNA molecules like a barcode and probe DNA methylation status. The sample preparation, DNA labelling and deposition for imaging will be integrated to allow rapid mapping of DNA molecules. At the same time nanopores will be explored as a route to high-throughput DNA mapping. FLUOROCODE will develop technology that aims to complement the information derived from current DNA sequencing platforms. The technology developed by FLUOROCODE will enable DNA mapping at unprecedented speed and for a fraction of the cost of a typical DNA sequencing project. We aniticipate that our method will find applications in the rapid identification of pathogens and in producing genomic scaffolds to improve genome sequence assembly."
Project acronym GLOBALVISION
Project Global Optimization Methods in Computer Vision, Pattern Recognition and Medical Imaging
Researcher (PI) Fredrik Kahl
Host Institution (HI) LUNDS UNIVERSITET
Summary Computer vision concerns itself with understanding the real world through the analysis of images. Typical problems are object recognition, medical image segmentation, geometric reconstruction problems and navigation of autonomous vehicles. Such problems often lead to complicated optimization problems with a mixture of discrete and continuous variables, or even infinite dimensional variables in terms of curves and surfaces. Today, state-of-the-art in solving these problems generally relies on heuristic methods that generate only local optima of various qualities. During the last few years, work by the applicant, co-workers, and others has opened new possibilities. This research project builds on this. We will in this project focus on developing new global optimization methods for computing high-quality solutions for a broad class of problems. A guiding principle will be to relax the original, complicated problem to an approximate, simpler one to which globally optimal solutions can more easily be computed. Technically, this relaxed problem often is convex. A crucial point in this approach is to estimate the quality of the exact solution of the approximate problem compared to the (unknown) global optimum of the original problem. Preliminary results have been well received by the research community and we now wish to extend this work to more difficult and more general problem settings, resulting in thorough re-examination of algorithms used widely in different and trans-disciplinary fields. This project is to be considered as a basic research project with relevance to industry. The expected outcome is new knowledge spread to a wide community through scientific papers published at international journals and conferences as well as publicly available software.
Computer vision concerns itself with understanding the real world through the analysis of images. Typical problems are object recognition, medical image segmentation, geometric reconstruction problems and navigation of autonomous vehicles. Such problems often lead to complicated optimization problems with a mixture of discrete and continuous variables, or even infinite dimensional variables in terms of curves and surfaces. Today, state-of-the-art in solving these problems generally relies on heuristic methods that generate only local optima of various qualities. During the last few years, work by the applicant, co-workers, and others has opened new possibilities. This research project builds on this. We will in this project focus on developing new global optimization methods for computing high-quality solutions for a broad class of problems. A guiding principle will be to relax the original, complicated problem to an approximate, simpler one to which globally optimal solutions can more easily be computed. Technically, this relaxed problem often is convex. A crucial point in this approach is to estimate the quality of the exact solution of the approximate problem compared to the (unknown) global optimum of the original problem. Preliminary results have been well received by the research community and we now wish to extend this work to more difficult and more general problem settings, resulting in thorough re-examination of algorithms used widely in different and trans-disciplinary fields. This project is to be considered as a basic research project with relevance to industry. The expected outcome is new knowledge spread to a wide community through scientific papers published at international journals and conferences as well as publicly available software.


Increasingly, CPA firms are realizing that the old compensation formulas no longer work, that performance "intangibles" need to be recognized, and that their compensation systems need to be performance-based. As a result, more and more firms are adopting compensation committees. This monograph answers the questions: What are Compensation Committees? How do they work? Why have they become so popular?


text:
Private Reception and Print Signing for Danny Simmons at Raven Fine Art Editions
Private Reception and Print Signing
for Danny Simmons at Raven Fine Art Editions
July 14, 2018 • 4 – 7 PM
Raven Fine Art Editions collaborated with artist Danny Simmons to create the new print edition, Deeper Desire.
Deeper Desire is a multi-media print comprised of four unique images, each printed on a sheet size of 22 x 30 inches. When joined, the four images create a unified work. The prints can be purchased individually or as a combined set. This series is made in a small production run intended for individual collectors.
Danny Simmons, Jr., is an American abstract painter, poet, and author. He strives to use painting as a spiritual conduit, and many of his works connect tribal musings to modern society. Much like modernists, he reworks or reimagines tribal paintings and markings into a modern context. His current work is inspired by textiles, and the artist uses dots, circles, and interconnected lines to form an abstract painting landscape. Simmons is also a poet and co-producer of the hit HBO series (and Tony-winning Broadway show) Def Poetry Jam with his siblings Russell Simmons and Joseph Simmons. He also heads the Rush Philanthropic Arts Foundation with his brother, Russell Simmons.
Raven Fine Art Editions is located in beautiful Williams Township, Pennsylvania, about 75 miles from New York City or Philadelphia. Painter and master printmaker, Curlee Raven Holton, is the founding director of Raven Fine Art Editions. Holton's paintings, drawings, and prints are held by major museums and collections in the U.S. and abroad. Raven Fine Art Editions has produced print editions by some of America's most important artists for collectors and major museums. As a private fine arts publisher, Raven Editions has achieved stellar results in the studio and gained recognition among collectors and institutions, both nationally and internationally.
Curlee Raven Holton, director of Raven Fine Art Editions, is proud to offer this opportunity for collectors to acquire an original print by Simmons, a creative artist and well-known arts leader. Patrons will have an opportunity to purchase the print with special pre-release pricing until July 14. This new work, comprised of four unique images, can be purchased either individually or as a combined set. The four images, each printed on a sheet size of 22 x 30 inches, have been conceived so that when joined they create a unified work.
Deeper Desireis a multi-media digital and serigraph print. The edition size of 124 prints includes 6 sets of the four combined prints and 25 each of the individual prints. The fine art print is conceived as an original work and is the result of a close collaboration between the artist and the print studio. This series is made in a small production run intended solely for individual collectors.
Danny Simmons in his Studio
Danny Simmons, Jr., is an American abstract painter, poet, and author. He strives to use painting as a spiritual conduit, and many of his works connect tribal musings to modern society. Much like modernists, he reworks or reimagines tribal paintings and markings into a modern context. His current work is inspired by textiles, and the artist uses dots, circles, and interconnected lines to form an abstract painting landscape.
Simmons is also a poet and co-producer of the hit HBO series (and Tony-winning Broadway show) Def Poetry Jam with his siblings Russell Simmons and Joseph Simmons. He also heads the Rush Philanthropic Arts Foundation with his brother, Russell Simmons.
Painter and master printmaker, Curlee Raven Holton, is the founding director of Raven Fine Art Editions. Holton's paintings, drawings, and prints are held by major museums and collections in the U.S. and abroad. He was the founding director of the Experimental Printmaking Institute at Lafayette College, and in 2014 he was appointed executive director of the David C. Driskell Center for the Study of the Visual Arts and Culture of African Americans, and the African Diaspora at University of Maryland, College Park.
Raven Fine Art Editions has produced print editions by some of America's most important artists for collectors and major museums. As a private fine arts publisher, Raven Editions has achieved stellar results in the studio and gained recognition among collectors and institutions, both nationally and internationally. Curlee Raven Holton and Raven Fine Art Editions have produced works of art in collaboration with artists such as Faith Ringgold, Sam Gilliam, Richard Anuszkiewicz, Grace Hartigan, Kay WalkingStick, and many others.
For information about the print edition, follow @ravenfinearteditions on Facebook or contact:
Susan Ellis, Raven Fine Art Editions, ravenfinearteditions@gmail.com.
Building Institutions Despite the Odds
A Daily Dose Of Poetry With Cynthia Short: Week One
Suzanne Jackson: Five Decades of Encouraging Life


NNP Spaitech produces UAVs based on its own developments in aerodynamics, avionics, microprocessor technology, computer technology and software.
After the approval of the basic concept, the engineer begins creating a 3d model in specialized software, where every detail of the future product is carefully worked out.
Also there is an aerodynamic blowing of products for the forecast of behavior of a product in air.
Here, the necessary adjustments are made, a program is then created for communication with the CNC machine and the process of manufacturing the tooling for the prototype production begins.
The entire development process is carried out using advanced technologies using unique materials and equipment. Developments Spaitech repeatedly became participants in international exhibitions and were awarded with awards. The development department has its own pilot production, which makes it possible to manufacture and test prototypes of equipment and software in the shortest possible time.
In addition to the full cycle of NPP development Spaitech carries out full preparation of the manufacturing technology, preparation of a complete package of documentation for the production and operation of its own UAV.


text:
// Copyright 2000-2019 JetBrains s.r.o. Use of this source code is governed by the Apache 2.0 license that can be found in the LICENSE file.
package com.jetbrains.python.codeInsight.typing;

import com.intellij.lang.Language;
import com.intellij.lang.injection.MultiHostRegistrar;
import com.intellij.openapi.util.Ref;
import com.intellij.psi.PsiComment;
import com.intellij.psi.PsiElement;
import com.intellij.psi.PsiLanguageInjectionHost;
import com.intellij.psi.util.PsiTreeUtil;
import com.jetbrains.python.codeInsight.PyInjectionUtil;
import com.jetbrains.python.codeInsight.PyInjectorBase;
import com.jetbrains.python.codeInsight.functionTypeComments.PyFunctionTypeAnnotationDialect;
import com.jetbrains.python.codeInsight.typeHints.PyTypeHintDialect;
import com.jetbrains.python.psi.*;
import com.jetbrains.python.psi.types.PyLiteralType;
import com.jetbrains.python.psi.types.PyType;
import com.jetbrains.python.psi.types.PyTypeUtil;
import com.jetbrains.python.psi.types.TypeEvalContext;
import org.jetbrains.annotations.NotNull;
import org.jetbrains.annotations.Nullable;

import java.util.Collection;
import java.util.regex.Pattern;

import static com.jetbrains.python.codeInsight.typing.PyTypingTypeProvider.ANNOTATED;
import static com.jetbrains.python.codeInsight.typing.PyTypingTypeProvider.ANNOTATED_EXT;
import static com.jetbrains.python.psi.PyUtil.as;

/**
 * Injects fragments for type annotations either in string literals (quoted annotations containing forward references) or
 * in type comments starting with <tt># type:</tt>.
 *
 * @author vlan
 */
public class PyTypingAnnotationInjector extends PyInjectorBase {
  public static final Pattern RE_TYPING_ANNOTATION = Pattern.compile("\\s*\\S+(\\[.*\\])?\\s*");

  private static final Pattern TYPE_IGNORE_PATTERN = Pattern.compile("#\\s*type:\\s*ignore(\\[[^]#]*])?\\s*($|(#.*))", Pattern.CASE_INSENSITIVE);

  @Override
  protected PyInjectionUtil.InjectionResult registerInjection(@NotNull MultiHostRegistrar registrar, @NotNull PsiElement context) {
    // Handles only string literals containing quoted types
    final PyInjectionUtil.InjectionResult result = super.registerInjection(registrar, context);

    if (result == PyInjectionUtil.InjectionResult.EMPTY &&
        context instanceof PsiComment &&
        context instanceof PsiLanguageInjectionHost &&
        context.getContainingFile() instanceof PyFile) {
      return registerCommentInjection(registrar, (PsiLanguageInjectionHost)context);
    }
    return result;
  }

  @Nullable
  @Override
  public Language getInjectedLanguage(@NotNull PsiElement context) {
    if (context instanceof PyStringLiteralExpression) {
      final PyStringLiteralExpression expr = (PyStringLiteralExpression)context;
      final TypeEvalContext typeEvalContext = TypeEvalContext.codeAnalysis(expr.getProject(), expr.getContainingFile());
      if (isTypingLiteralArgument(expr, typeEvalContext) || isTypingAnnotatedMetadataArgument(expr, typeEvalContext)) {
        return null;
      }
      if (PsiTreeUtil.getParentOfType(context, PyAnnotation.class, true, PyCallExpression.class) != null &&
          isTypingAnnotation(expr.getStringValue())) {
        return PyTypeHintDialect.INSTANCE;
      }
      if (isInsideValueOfExplicitTypeAnnotation(expr)) {
        return PyTypeHintDialect.INSTANCE;
      }
    }
    return null;
  }

  private static boolean isInsideValueOfExplicitTypeAnnotation(@NotNull PyStringLiteralExpression expr) {
    PyAssignmentStatement assignment = PsiTreeUtil.getParentOfType(expr, PyAssignmentStatement.class);
    if (assignment == null || !PsiTreeUtil.isAncestor(assignment.getAssignedValue(), expr, false)) {
      return false;
    }
    return PyTypingTypeProvider.isExplicitTypeAlias(assignment, TypeEvalContext.codeAnalysis(expr.getProject(), expr.getContainingFile()));
  }

  @NotNull
  private static PyInjectionUtil.InjectionResult registerCommentInjection(@NotNull MultiHostRegistrar registrar,
                                                                          @NotNull PsiLanguageInjectionHost host) {
    final String text = host.getText();
    final String annotationText = PyTypingTypeProvider.getTypeCommentValue(text);
    if (annotationText != null) {
      final Language language;
      if (PyTypingTypeProvider.TYPE_IGNORE_PATTERN.matcher(text).matches()) {
        language = null;
      }
      else if (isFunctionTypeComment(host)) {
        language = PyFunctionTypeAnnotationDialect.INSTANCE;
      }
      else {
        language = PyTypeHintDialect.INSTANCE;
      }
      if (language != null) {
        registrar.startInjecting(language);
        //noinspection ConstantConditions
        registrar.addPlace("", "", host, PyTypingTypeProvider.getTypeCommentValueRange(text));
        registrar.doneInjecting();
        return new PyInjectionUtil.InjectionResult(true, true);
      }
    }
    return PyInjectionUtil.InjectionResult.EMPTY;
  }

  private static boolean isTypingLiteralArgument(@NotNull PsiElement element, @NotNull TypeEvalContext context) {
    PsiElement parent = element.getParent();
    if (parent instanceof PyTupleExpression) parent = parent.getParent();
    if (!(parent instanceof PySubscriptionExpression)) return false;

    final PyType type = Ref.deref(PyTypingTypeProvider.getType((PySubscriptionExpression)parent, context));
    return PyTypeUtil.toStream(type).allMatch(PyLiteralType.class::isInstance);
  }

  private static boolean isTypingAnnotatedMetadataArgument(@NotNull PsiElement element,
                                                           @NotNull TypeEvalContext context) {
    final PyTupleExpression tuple = as(element.getParent(), PyTupleExpression.class);
    if (tuple == null) return false;
    final PySubscriptionExpression parent = as(tuple.getParent(), PySubscriptionExpression.class);
    if (parent == null) return false;

    final PyExpression operand = parent.getOperand();
    final Collection<String> resolvedNames = PyTypingTypeProvider.resolveToQualifiedNames(operand, context);
    if (resolvedNames.stream().anyMatch(name -> ANNOTATED.equals(name) || ANNOTATED_EXT.equals(name))) {
      return tuple.getElements()[0] != element;
    }
    return false;
  }

  private static boolean isFunctionTypeComment(@NotNull PsiElement comment) {
   final PyFunction function = PsiTreeUtil.getParentOfType(comment, PyFunction.class);
    return function != null && function.getTypeComment() == comment;
  }

  private static boolean isTypingAnnotation(@NotNull String s) {
    return RE_TYPING_ANNOTATION.matcher(s).matches();
  }

  public static boolean isTypeIgnoreComment(@NotNull PsiElement comment) {
    if (!(comment instanceof PsiComment)) return false;
    String text = comment.getText();
    if (text == null) return false;
    return TYPE_IGNORE_PATTERN.matcher(text).matches();
  }
}

redpajama_set_name: RedPajamaGithub