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Together for the Gospel	menu
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http://media.t4g.org/t4g2012/audio/t4g2012-panel2.mp3
Preaching: Is There a Plan B? (Panel II)
Speakers: Albert Mohler, C.J. Mahaney, Ligon Duncan, Mark Dever	Year: 2012	Session: Panel Session
God always creates, calls and reveals by his Word. In this day and age, preachers have lost confidence in the ways in which God uses the Bible. This panel discusses the centrality the proclamation of God's word has to worship the living and true God. A pastor who has a lack of confidence in the Word will often have a lack of confidence in preaching.
Ligon Duncan
R. Albert Mohler Jr. serves as the ninth president of The Southern Baptist Theological Seminary. Dr. Mohler is a theologian and an ordained minister, having served as pastor and staff minister of several Southern Baptist churches. He came to the presidency of Southern Seminary from service as editor of The Christian Index, the oldest of the state papers serving the Southern Baptist Convention. Dr. Mohler is a member of Third Avenue Baptist Church in Louisville, Kentucky. He is the author of The Apostles' Creed: Discovering Authentic Christianity in an Age of Counterfeits, The Prayer that Turns the World Upside Down, We Cannot Be Silent, The Conviction to Lead, He is Not Silent, Culture Shift: Engaging Current Issues with Timeless Truth, and Atheism Remix. He is married to Mary, and they have two children, and are the proud grandparents of Benjamin and Henry.
C.J. Mahaney serves as the Senior Pastor for Sovereign Grace Church of Louisville and is the author of several books, including Living the Cross Centered Life, Humility: True Greatness, Don't Waste Your Sports, and Sex, Romance and the Glory of God. C.J. and his wife, Carolyn, have three married daughters, one son, and twelve grandchildren. They reside in Louisville, Kentucky but C.J. cheers for his hometown teams the Washington Redskins, Nationals, Wizards, and University of Maryland basketball.
Ligon Duncan is Chancellor/CEO of Reformed Theological Seminary, and John E. Richards Professor of Systematic and Historical Theology. Born in Greenville, South Carolina, and reared in a Christian home, he did his studies at Furman University, Greenville, SC (BA); Covenant Theological Seminary, St. Louis (MDiv & MA); and the University of Edinburgh, Scotland (PhD). Ligon and his wife, Anne, have two children. Ligon has edited, written, and contributed to numerous books, most recently including: The Gospel As Center, Recovering Biblical Manhood and Womanhood, Preaching the Cross, Fear Not: Death and the Afterlife from a Christian Perspective, In My Place Condemned He Stood, and Does Grace Grow Best in Winter?.
Mark Dever serves as the senior pastor of Capitol Hill Baptist Church in Washington, DC. A Duke graduate, Mark holds a M.Div. from Gordon-Conwell Theological Seminary, a Th.M. from The Southern Baptist Theological Seminary, and a Ph.D. in Ecclesiastical History from Cambridge University. He is the president of 9Marks and has taught at a number of seminaries. Mark has authored several books and articles, most recently, Compelling Community, Baptist Foundations, The Gospel and Personal Evangelism, What is a Healthy Church?, and Nine Marks of a Healthy Church. He and his wife Connie live and minister on Capitol Hill. They have two adult children.
Inerrancy: Did God Really Say…? (Panel V)
Panel Session 2012
Albert Mohler, John Piper, Ligon Duncan, Mark Dever, Peter Williams, Simon Gathercole
Celebrity Pastor: Indecent Exposure? (Panel VI)
C.J. Mahaney, Carl Trueman, David Platt, Ligon Duncan, Matt Chandler, Thabiti Anyabwile
Contextualization: Lost in Translation? (Panel IV)
Albert Mohler, Kevin DeYoung, Mark Dever, Matt Chandler, Thabiti Anyabwile
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redpajama_set_name: RedPajamaCommonCrawl


Benfica 10 0 S.L. Benfica Season. The 2009–10 European football season was the 106th season of Sport Lisboa e Benfica's existence and the club's 76th consecutive season in the top flight of Portuguese football.
Benfica V Dinamo Zagreb. Attempt missed. João Félix (Benfica) right footed shot from the right side of the box misses to the left. Assisted by Rafa following a fast break.
Benfica Women Undefeated After Four Games And 85 Goals. Benfica beat Ponte de Frielas 28-0. There are sporting mismatches, but there's no holding back Benfica Women as they recorded their second 28-0 win of the season on Sunday.
Benfica 10 0 ial Do Sport Lisboa E Benfica. Site Oficial do Sport Lisboa e Benfica, onde podes ficar a par de toda a atualidade do teu Clube e ainda ver os melhores vídeos e resumos de todos os jogos!


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redpajama_set_name: RedPajamaGithub


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Celebrate LGBTQ+ Pride Month
By Adult Librarian on May 27, 2021 in Adult
Lesbian, Gay, Bisexual, Transgender and Queer Pride Month (LGBTQ) is celebrated in June to commemorate the anniversary of the 1969 Stonewall riots in Manhattan, New York City. This event marks the beginning of the movement to outlaw discriminatory laws and practices against LGBTQ+ Americans. Pride Month is also a way to acknowledge the influence and importance of LGBTQ+ individuals, foster a spirit of community among members and allies, and call attention to the continued need for equal rights and visibility. Learn more about LGBTQ+ Pride Month from the Library of Congress.
To help celebrate, we'll give you a little history, some resources,
some books to read and movies to watch.
Remembering Stonewall (StoryCorps)
LGTB Rights Milestones Fast Facts
Celebrate:
35 Ways to Celebrate Pride and LGBTQ Rights
CT Pride Celebrations 2021 – Here are some of the events planned for towns all over the state, both in-person and virtual.
Fairfield County Pride 2021 – Join Triangle Community Center this June for a month-long celebration of the LGBTQ community.
Let's Go Birding Together! A Pride Month Birding Celebration
Gay Pride Calendar – From IGLTA, the International Gay & Lesbian Travel Association
Guide to Being an Ally to Transgender and Nonbinary Youth (The Trevor Project)
It Gets Better Project – A nonprofit organization with a mission to uplift, empower, and connect lesbian, gay, bisexual, transgender, and queer youth around the globe.
Gay, Lesbian, Straight Education Network (GLSEN) – Works to ensure that LGBTQ students are able to learn and grow in a school environment free from bullying and harassment.
LGBTQ+ Comprehensive Health & Well-being Guide (Drugwatch)
Trans Student Equality Resource (TSER) – A youth-led organization dedicated to transforming the educational environment for trans and gender nonconforming students through advocacy and empowerment.
National Women's History Museum LGBTQIA+ Pride Month Resource Toolkit – Learn more about Pride month and LGBTQIA+ issues each day with this interactive toolkit
Local Resources:
The Safe Harbor Project – Guarantees fair and equal treatment, services and resources for LGBT youth and families in Connecticut and is a collaboration between the Department of Children and Families (DCF) and True Colors, Inc.
PFLAQ Norwalk – Triangle Community Center – PFLAG is the nation's largest family and ally organization, uniting people who are lesbian, gay, bisexual, transgender and queer (LGBTQ) with families, friends and allies. PFLAG is committed to advancing equality and full societal affirmation of LGBTQ people through its threefold mission of support, education, and advocacy.
Book & Media Lists:
Here at the Stratford Library we celebrate and support the diversity of our community. Explore the culture, heritage, contributions and achievements of folks in the LGBTQ+ community with our reading and watching recommendations:
LGBTQ Pride Books Fiction
LGBTQ Pride Books
Rainbow Pride Books
History & Resources
LGBTQ E-books,
audiobooks & video
LGBTQ Films
Lambda Literary YA Book Reviews – For over 30 years, Lambda Literary has dedicated itself to championing LGBTQ literature and supporting LGBTQ writers at all stages of life.
Rainbow Library – LGBTQ+ Affirming K-12 E-Books for Your Computer, Phone, Tablet, or
E-Reader.
Stonewall Wall Book Awards – The first and most enduring award for LGBTQIA+ books, sponsored by the American Library Association's Rainbow Round Table.
Game Chat, Graphic Book Club & Grab 'N' Go Kits PLUS Great Self Care Reads!
DIY Storytime – Growing Things


In the next day or two we can expect to see another price movement for bitcoin. Do you think it will break bearish or bullish? Hit like if you like this analysis.
MBH is forming a decade long ascending triangle. No breakout yet, but can it break 100p? Good results show potential for a bullish move, but the pattern is soon to be completed. Need to check in 12 months from now.
I'm not sure if this is a rising wedge (bearish), a pennant (bullish) or even an ascending triangle. Any comments?
Ascending triangle but conflicts with 1h H&S and rising wedge?
Bullish after a breakout of 70p resistance, which has been in place since March 2016.


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, también conocido como Goodbye, Eri, es un manga web one-shot japonés escrito e ilustrado por Tatsuki Fujimoto. Fue lanzado en el sitio web Shōnen Jump+ de Shūeisha el 11 de abril de 2022 y publicado en forma impresa el 4 de julio de 2022.

Argumento
Yuta Ito recibe un teléfono inteligente por su cumpleaños. Poco después de abrir su regalo, la madre enferma terminal de Yuta le asigna la tarea de filmarla y compilar una película sobre ella en caso de su muerte. Después de que ella muere, Yuta estrena la película en su escuela, pero se burlan mucho de su decisión de terminar la película con él huyendo de un hospital en explosión. Acosado y condenado al ostracismo, Yuta decide suicidarse saltando desde el techo del hospital de su madre. Lo detiene una chica llamada Eri, quien le revela que realmente le encantó su película y lo insta a hacer otra. Los dos trabajan juntos para llevar esto a buen término, alternando entre la producción y el maratón de varias películas en busca de inspiración y educación. Deciden hacer de la película un semidocumental sobre ellos mismos, pero con varias exageraciones y elementos ficticios, sobre todo la idea de que Eri es una vampira .

Yuta y Eri se vuelven más cercanos a medida que pasan el tiempo hasta que Eri cae inconsciente mientras los dos jugaban en la playa. Se revela que Eri también tiene una enfermedad terminal como la madre de Yuta. Un Yuta deprimido no se anima a intentar más progresos en su película. Sin embargo, su padre lo alienta a seguir adelante, al mismo tiempo que le revela al lector que la madre de Yuta en realidad abusaba de su hijo y esposo. La película hizo que Yuta hiciera era un intento de capitalizar su enfermedad si sobrevivía, o recordarla de manera positiva si moría.

Yuta y Eri completan su película, poco antes de que Eri muera. Yuta proyecta su nueva película, que esta vez recibe elogios. Más tarde, Yuta se enfrenta a uno de los amigos de Eri, y los dos admiten que Eri no era la versión idealizada que Yuta filmó y editó para su película, pero ambos están de acuerdo en que prefieren recordar a su amiga en común de esta manera.

Desde entonces, Yuta dedica tiempo a equilibrar su vida normal con su obsesión por volver a editar la película de Eri. Años más tarde, un Yuta adulto sufre la pérdida de su esposa, hijo y padre en un accidente automovilístico. Perdiendo las ganas de vivir, Yuta había decidido una vez más intentar suicidarse en la sala de proyección donde él y Eri verían una maratón de películas. Al llegar allí, Yuta descubre a una Eri todavía viva y joven. Eri revela que ella realmente es una vampira que repetidamente experimenta pérdida de memoria causada por ciclos de muerte cerebral a lo largo de su vida eterna. La Eri de su vida anterior había dejado instrucciones específicas para sus futuras encarnaciones, así como la película que ella y Yuta hicieron para asegurarse de que lo recordará para siempre. Con su voluntad de vivir restaurada, Yuta se despide de Eri y se va con indiferencia mientras el edificio en el que se encontraba la sala de proyección explota al igual que en el final de su película sobre su madre.

Publicación
El 4 de febrero de 2022, Shihei Lin, editor de Shūeisha, anunció que Tatsuki Fujimoto escribiría un one-shot de 200 páginas, que se publicó en el sitio web Shōnen Jump+ el 11 de abril de 2022. El manga se publicó en forma de tankōbon el 4 de julio de 2022.

Viz Media y Manga Plus publicaron el manga simultáneamente con el lanzamiento japonés.

Recepción
Un día después de su lanzamiento, el manga obtuvo más de 2,2 millones de visitas en el sitio web Shōnen Jump+.

Adi Tantimedh de Bleeding Cool elogió la trama y los personajes, calificándolo como uno de los mejores cómics de 2022. Tyra de Animate Times elogió la trama y la obra de arte, destacando particularmente la división de viñetas y otros efectos.

Referencias

Enlaces externos
  en Shōnen Jump+
  en VIZ Media

Manga de 2022
Mangas publicados en Shōnen Jump+
Series de manga publicadas por Shūeisha
Shōnen

redpajama_set_name: RedPajamaWikipedia


If yesterday, Tuesday, wasn't a day for rosé, I'm not sure what is! With February temperatures in the 60s, in NY, drinking pink was definitely the way to go.
I was originally going to try just a taste. And I did. Then I figured a glass wouldn't hurt. Oops! Had a little more. Thankfully there is about a glass in there for me to enjoy tonight. Well, there goes, #nowineweekdays, lol. Leone De Castris Five Roses rosé, while technically not sweet, is absolutely not dry. We can call it semi-dry.
Don't let the pink color fool you. This wine, from the nose to the glass, is all about luscious red fruit. Cherry is the predominant note up front, with raspberry, and strawberry filling out the midpalate quite nicely. The finish has very little acidity, so if that's something you like, this would not be the wine for you. The finish has rather soft watermelon notes.
This wine is great with food. I had it with curry mixed vegetables. And I'm sure it will drink wonderfully on its own as I plan to finish the rather small glass, I left myself, with Project Runway All Stars tonight.
With an average price of only $13, it's the perfect wine to stock up to welcome spring. I really hope the groundhog is right!


Meg Favreau is a writer and comedian living in Los Angeles. Her writing has appeared in McSweeney's, The Big Jewel, The Huffington Post, Table Matters, and The Smew. Her book with photographer Michael Reali, Little Old Lady Recipes: Comfort Food and Kitchen Table Wisdom, was released in November 2011 by Quirk Books. She's currently the senior editor at the frugal living and personal finance site Wise Bread, and a regular guest on American Public Media's Marketplace Money.


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E3 2017: Mario+Rabbids Preview
Joe Molohon June 15, 2017 E3Features
Alongside Mario Odyssey, Mario+Rabbids: Kingdom Battle is proving to be one of the most popular games at E3 this year. And with good reason, it would seem!
For those who have played these, let me just say that the new Mario+Rabbids game reminds me of a cross between XCOM and Worms: Armageddon. Like XCOM, Mario+Rabbids exhibits a similar playstyle and usage of strategy. Character movements are plotted out beforehand on a grid of sorts, multiple kinds of actions are allowed each turn, and cover figures highly into succeeding and performing well. And like Worms, Mario+Rabbids portrays its violence as largely comedic and harmless, and there's a certain zaniness that pervades every aspect of the game. Walking through the environments between encounters, I found rabbids doing everything from taking turns hitting each other to bathing in swimming pools with giant rubberduckies. It's an interesting combination and I think it works so far.
The Mario+Rabbids demo was a glorious twenty minutes of gameplay; well worth the two hours I waited to play it. It's proven to be one of the longest demos at E3, giving players the chance to play through up to three levels. We're even able to buy and try new weapons for our characters, though things like skills and upgrades were saved for the launch version.
What I like best about Mario+Rabbids is probably those weapons. The weapons are such that even their aesthetic design displays a high level of creativity; from the few weapons I've seen, it would seem that there is a wide variety of effects and it would seem that these effects contribute to creating the identity of each character. Rabbid Luigi, for example, was able to buy a laser gun that gave him a vampirism ability, whereas Mario had an extremely powerful bullet bill gun that could knock enemies up into the air (and potentially off the stage). And alongside the capabilities and design of these weapons, I enjoy their ease of use. Mario+Rabbids encourages the combo-ing of actions and abilities; having Rabbid Luigi slide-kick the baddie, vault off Mario to a safe location and then shoot him, for example.
In addition, shooting is fairly streamlined; characters will lock on to any enemy within range and will directly target them. This means leaning around a corner to shoot the enemy on the other side (a direct hit) and shooting straight for the wall or piece of cover between that character and the enemy. This allows for some very interesting situations and it really gets you thinking about the strategy of your character placement and order of movement.
If I had one concern to note about Mario+Rabbids thus far, it would be the difficulty. Mario+Rabbids is a little too easy right now, as I breezed through all of the given levels. I almost died in the last demo level, but only because the level contained an infinite number of big rabbids and I was looking to push the envelope on what I could do. That being said, nothing was much of a challenge in the demo.
Tomorrow's the last day of E3, unfortunately, and I'm still looking to get to play Mario Odyssey. I came extra-early today, was one of the first 200 people in line maybe, but the line to play Odyssey capped long before I had a chance. So I'll be showing up extra-extra-early tomorrow morning and bolting straight for that line come doors' opening. I guess the chance to play the new Mario is enough of a reason to make a fool of myself.
Previous ArticleAn E3 Mystery
Next ArticleE3 2017: Mario Odyssey Preview
Joe Molohon
As a gamer and a writer, people often accuse Joe of living in a fantasy world. That's not true though; Zelda is just as real as anything else.


Moving pictures get attention. If you're not using video on your website or regularly in your social media feeds, you are not getting the attention you deserve.
From Press & PR to event and commercial, photography is a timeless element in all communications.


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Elite Tours International > State Reserve Badkhyz
State Reserve Badkhyz
In Mary province, along the border with Afghanistan, between the rivers Murghab Kushka and an area of about 88,000 hectares spread Badkhyz Reserve. Its history began in 1941. It was intended to save the remaining small population of Asiatic wild ass, gazelles and Turkmen urialov. It is also required to protect and preserve for the study of wild nature biogeocoenosis, including pistachio bushes. In 1956, the reserve land holdings included three reserves – Chemenabit, Kyzyldzhar and Pulihatum. There are ponds, from which the drinking birds and animals, their safety is very important in arid areas. In addition to the Asiatic wild asses, like a light-brown donkey, on the verge of extinction were leopards, wild boars, gazelles and urialy. All of these animals in the reserve took under protection.
In Badkhyz inhabits 40 species of mammals, 250 species of birds – a golden eagle, vulture, rock nuthatch, vulture, etc. The local desert and steppe region are a paradise for reptiles. Varan, cobra, viper, Afghan, arrow etc., they are no less than 34 species.
Flora Badkhyz widely is endemics – species that exist only in these climatic and territorial conditions. In the spring blooms here a fabulous multi-colored carpet of tulips, astragalus and sainfoin – about 60 species. In addition to them in the reserve grows about 550 species of higher plants – ferula, saxaul, pistachio, but all of them, and you name it.


celebrating those who make CCI – our members. Meet Lori!
Check out the stories of more of our justice fighters here!
On Tuesday, July 28 CCI's racial justice team met with Des Moines Police Chief, Dana Wingert. This was an initial meeting – where we told racial profiling stories and stories about people's experience with the complaint process, wanted to raise important questions and hear what the Chief will do to make sure all people are treated fairly by the police. We also presented what we want changed with the complaint process so everyone feels they can file a complaint and treated with respect when they do file.
There will be more meetings to come –we still have a lot of work to do but this was a good first step!
Do you believe racial profiling exists in Des Moines?
Chief Wingert said the DMPD has changed – the old officers, many who are now retired, had a warrior mentality. He said there are many young people on the force currently and they have a "progressive" mindset.
We asked this follow- up question – "have you ever worked with a racist police officer?" Chief Wingert and Officer Knox both said they haven't worked with a racist officer in their history of working on the force. He said some officers past actions, though not racist, would not be allowed on the force currently.
What are you going to do so black mothers and fathers don't have to have a conversation with their children about interacting with the police?
Chief Wingert talked about some of the things they're currently doing: roundtable conversations with youth, getting youth and police officers together, having kids do ride-alongs with officers, and a new criminal justice class in public schools taught by officers.
Sharon then asked about how they're connecting with the 20-30 year olds in the community. He said that's a group of people they're having trouble connecting with and they are open to ideas.
Do you have statistics on the number of stops, arrests and active complaints? Do you report these statistics to the Justice Department?
Yes, they record stats and are required by law to report stats to the Justice Department.
Every week, Wingerts gets a report of all officers regarding any excessive force used and complaints issued.
Do you ask specific questions about racism during the polygraph test officers receive?
Yes, they do ask specific questions about racism – such as "Are you a part of the KKK?" It is considered a medical test now and is one of the best tests the potential officer can receive to test racism, according to Wingert.
What sort of trainings do officers receive?
Every year there is a mandatory four hour sensitivity training session and he said there is a lot of training at the Police Academy. There is also crisis intervention (mental health) training.
He's trying to get training by the Department of Justice on unconscious bias.
What is the range of disciplinary action he takes?
Levels of discipline range from re-instruction, verbal counseling (they go over policy), a written reprimand that goes in their file, suspension, or termination (Wingert has terminated 6 people).
Is there an appeal process if you don't agree with the outcome of a complaint?
Yes – you can appeal to the city manager and the Human Rights Commission. Then the City, Legal and the Chief discuss (so, still an internal process).
We discussed the specific changes we'd like to see with the complaint process. One attendee started by sharing her experience filing an official complaint with the Office of Professional Standards and how she felt like she was on trial and treated unprofessionally.
Official complaint form available online and follow up by the Office of Professional Standrads within 48 hours.
All complaints are given a case number.
Consistent timelines for investigation – 30 day response time.
Person filing complaint is allowed a citizen advocate or person of their choosing to be with them throughout whole process, including interview process.
Transparency of the investigation – progress is shared to the citizen.
Each citizen is given notice of how you can appeal and given information about the Iowa Civil Rights Commission.
Statistics of complaints – how many filed, demographics of who's filing and outcomes of the complaint.
Wingert said because of Rosa Ruiz and her experience with the complaint process they started giving everyone who files a complaint a card with the investigator's number and their case number on it.
Officers are required to carry business cards. Currently, they don't have their names on it. They have to fill that in. It could change to where they'll get individual business cards. They are required to give it to you if you ask.
Body cameras – Wingert says it's coming but the main issue is public privacy and who has access to it. He's working with the ACLU and Bruce Hunter on legislation that takes into account the privacy concerns.
Police car cameras – they run when the lights are on but there is a failsafe system so it's almost always recording.
Racial profiling policy – DMPD does have one and Wingert had a hand in drafting it.
We closed the meeting asking what he thought about a citizen review board and asked him to note that we think it's important to have one in Des Moines. We will keep working on making that happen. We also asked him to examine the proposed complaint process changes.
Alicia Garza came to Des Moines to talk about the movement to end anti-black racism and to achieve racial justice: #blacklivesmatter. She captured the room's attention with profoundly engaging and necessary words.
"Race in this country was constructed on black bodies. We have to understand the roots of anti-blackness in all of our communities. It's even in our language. When we say black-list what do we mean? It is in our country's DNA.
The work that we do together has to be courageous enough to dismantle that. It's about changing laws, structures, and the ways in which we relate to each other.
The Des Moines Register covered the event beautifully.
Monthly racial justice meetings – CCI members meet monthly to dig in on our campaign to stop racial profiling in Des Moines and in Iowa.
Economic and racial justice depend on each other. Fight for $15 campaign – we're working for a $15/hr. minimum wage. One way that's happening? Fast Food Fridays!
Every second and fourth Friday of the month, we take action outside of a local fast food restaurant calling for $15/hr.
Alicia's coming back – join us October 2-3 for our 40th annual convention. Register here!
Keep an eye out for details on how you can join us and take action for a better Iowa.
celebrating those who make CCI – our members. Meet Kaija!
Members of the community that have an issue regarding an interaction with the police, such as racial profiling, are encouraged to file acomplaint with the Office of Professional Standards (OPS).
In October of 2014, when Rosa Ruiz was harassed and racially profiled by an off-duty Des Moines police officer, we decided to follow protocol and submitted a complaint with OPS. Watch what happened by clicking on the video above.
OPS has two types of complaints – formal and informal. There are no criteria to determine what constitutes as formal or informal; that is up to the discretion of the Captain and sergeants in charge of OPS. Rosa submitted a complaint with the goal of receiving an apology from the officers and also sought proper disciplinary action for the off-duty officer. Unfortunately, Rosa's complaint was not taken seriously and was quickly dismissed by OPS and the DMPD.
In light of the failure of OPS's complaint process to provide justice for Rosa, she decided to take another route. With the help of Iowa CCI, Rosa submitted a formal complaint to the Iowa Civil Rights Commission (ICRC). The ICRC is one of the only agencies that has the power to investigate police practices and they do so from an unbiased perspective. However, this process can be very lengthy – anywhere from 6 months to a year.
To begin the process, a person must submit the brief complaint form to the ICRC. Once the form is received it is filed into their system and assigned a case number which takes about two weeks. Once it has been filed, the ICRC mails a three-part questionnaire to each party. In Rosa's case one was mailed to Rosa and another was mailed to the DMPD. The questionnaire seeks a detailed account of each party's experience and recommends returning the questionnaire with any evidence, such as witness testimonies or footage, to the ICRC. Once the ICRC receives both party's questionnaires it is filed back into the system where it waits to be assigned to an investigator for screening. This wait period can take anywhere from 30 days to 120 days. At the end of this initial screening the ICRC investigator makes a claim in favor of one party or the other and sends copies of both party's questionnaires and findings to both parties.
At this point, the party who submitted the complaint has two options – mediation or continued investigation. Mediation involves a representative of both parties meeting with an ICRC investigator separately to find a common ground; continued investigation involves a team of ICRC investigators to meet with both parties, witnesses, and have access to all evidence, such as footage or recordings. A continued investigation has the potential to lead to a lawsuit. If a party wishes to pursue continued investigation their case goes back into the system and waits for assignment which can take up to 30 days. Once it has been assigned there is no timeline for how long it could take to resolve the complaint.
Rosa's racial profiling complaint with the Iowa Civil Rights Commission (ICRC) was submitted on October 16th, 2014. Rosa completed the detailed questionnaire and submitted it on November 12, 2014; it was filed for the ICRC screening process on November 18, 2014. Rosa's complaint made it through the screening process on February 26, 2015. Rosa received a letter on March 4, 2015 disclosing information about an option for a mediation session. During the four-month period between her submission of the ICRC complaint and the end of the screening process, Rosa attempted to meet with the DMPD numerous times to resolve the on-going issue. For various reasons, the DMPD and City Attorney's Office continued to decline her invitation to meet.
On March 26, 2015 Iowa CCI received a letter from the City Attorney's Office explaining that any future communication should not be with the DMPD but with Carol Moser, a City Attorney. Rosa declined the mediation option. Her goal was to speak to off-duty officer and get an apology from him. She did not see mediation with the City Attorney's office as productive because there would be no acknowledgement of the horrific behavior of this officer. She declined mediation via a phone call to the ICRC on March 27, 2015. Her ICRC, the agency with power to investigate police practices, complaint was filed back into the system shortly after. Her case did get assigned to an investigative specialist for continued review.
We will keep you posted as this case develops. If you have been racially profiled, or want to learn more, call the office at 515.282.0484.


Get the most from your paid advertising with Twitter Ads by tracking your booking conversions using a Twitter tracking pixel.
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2. Select the "Tools menu" menu at the top of the page and choose the "Conversion tracking" menu option.
3. Click "Create new conversion event"
Please note: if you have already created a Twitter Pixel ID, open an existing conversion event to find it.
4. When creating the new conversion event, select the "universal website tag" option and track "all website visits". Agree to the terms and conditions and click "save conversion event".
5. Copy your Twitter Pixel ID.
6. Log in to your TicketSource dashboard and select the "Settings |Analytics and Tracking" menu option. Tick the option "Enable Twitter pixel tracking on box office pages", enter the Twitter Pixel ID and click "save changes".
Your Twitter Pixel will track completed bookings for your TicketSource event.


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This Policy applies to the informationprocessed through our public website (including any subdomains and mobileversions thereof, the "Corporate Site"),and our subscription-based RK360 Cloud Record Platform (the "Service").
Please take a moment to read this PrivacyPolicy (the "Policy") to understandhow we collect, use, and share Personal Data of users of our Corporate Site andService ("you" or "your"), as well as your choices and rightswith respect to this information.
The Service and Corporate Site are ownedand operated by Prosocial Applications, Inc. (RedKangaroo, "us," "our," or "we"), a Colorado corporation with anaddress of 1905 15th St. #4585 Boulder CO 80302-4585. See below for how to contact us.
ThisPolicy is incorporated into the Terms of Service governing your use of theService. Any capitalized terms not defined in this Policy will have thedefinitions provided in our Terms of Service. Your use of our Corporate Site or Service indicates your acknowledgementof this Policy.
This Policy does not applyto information processed by third parties, for example, information created andstored by your health care provider, unless and until we receive yourinformation from them. Please review these third parties' privacy policies tolearn more about how they process your Personal Data.
Identity Data: Personal Data used to identify aperson, such as your name, photo/avatar, username, identification documents, andother Personal Data you may provide during account registration or to proveyour identity.
Contact Data: Personal Data used to contact anindividual, e.g. email address(es), physical address(es), phone number(s), orusernames/handles, as well as a name or other salutation.
Financial Data: Personal Data relating to financial accountsor services, e.g. a credit card or other financial account number, or otherrelevant information you provide in connection with a financial transaction.
Device Data: Pseudonymous Personal Data relating toyour device, browser, or application e.g. IP addresses, MAC addresses, applicationID, cookie identifiers, session navigation history and similar browsing metadata,and other data generated through applications, browsers, cookies, and similartechnologies.
Health Records: Health care records,and any Personal Data in them, that we receive from health care providers, suchas allergy records, vital statistics, lab tests and results,prescription/medication data, and information relating to medical proceduresand medical conditions. This information includes Special Category Data.
Health Profile Data: Personal Data you provideto us about you and your health including, blood type, race, ethnicity,religious affiliation, language, education, diet/digestion, lifestyle, knownhealth conditions and certain medical history, allergies, and medications, andother information relating to your health. This information includes SpecialCategory Data.
User Content: Information that a userprovides in a message, free text field, video/chat, in a file upload, scan orphoto, or unstructured format, including any Personal Data or Special CategoryData to the extent contained in or revealed by such content.
Data: An"RK360 Record" is a database account that stores Health Records and otherhealth information of a patient or "Record Owner." A Record Owner may manageher own RK360 Record as "Record Administrator"; may at any time delegatemanagement to another person as Record Administrator; or, a RecordAdministrator with guardianship rights may manage the RK360 Record withoutRecord Owner authorization. Record Administrators may grant and control accesspermissions of "Authorized Users" to RK360 Records. By default, Record Ownersand Record Administrators are Authorized Users of RK360 Records.
Please Note:In certain cases, third parties (such as a Provider or other Distributor of theService) may initiate registration of an RK360 Record (e.g. as part of aProvider's own operations) on behalf of a Record Owner who appoints self orother as Record Administrator. The Record Administrator, may, in turn, appointthe initiating Provider or other Distributor of the Service as Authorized Userson the RK360 Record.
When you first register an RK360 Record as a Record Owner or RecordAdministrator or first access an RK360 Record as an Authorized User, we will requestand process Identity Data, Device Data andcertain Contact Data, such as a copyof driver's license, passport or other ID, and email address.
We may also process certain FinancialData or Insurance Data if youchoose to subscribe to our Service, or otherwise pay or seek payment for oursubscription fees. This Financial Data may be processed by us, a serviceprovider on our behalf, or may be completed outside of our Service (e.g.through the Apple App Store).
Uses: We use the Identity Data and Contact Data as necessary to authenticate Users andto provide you with important information about your RK360 Record. FinancialData provided at registration will be used only as necessary to processtransactions at your request, or to store your information for use in futurepayments. Subject to Your Rights & Choices, we may also use IdentityData and Contact Data in connection with Marketing Communications, for Product and Service Improvement, and Information Security.
Data: Our Service allowsAuthorized Users, consistent with their permissions, to request import of HealthRecords and other health information into RK360 Records from diverse external sourcesincluding the electronic health records of healthcare providers ("Providers"). In connection with such requests,our Service will process any designated IdentityData, Health Profile Data, Health Records, InsuranceData, and User Content.
Please note: Our Service enables Authorized Users to request from Providers viaintermediary technology services such as Apple Health the import of HealthRecords, which are generated and controlled by Providers or their businessassociates. Therefore, data we import into RK360 Records may be inaccurate orincomplete depending upon the content of source records, and the quality ofintermediary technology services. See Your Rights & Choices for information regarding data accuracy and correction.
Uses: Our Service generallyprocesses Identity Data, Health Profile Data, Health Records, Insurance Data andUser Content as necessary to provide the Service, and in accordance with each AuthorizedUser's consent, requests, preferences and permissions.
Our Service maycollect and process Identity Data, which may include driver's license,passport, or insurance information, when you provide patient authorizations andmedical power of attorney or upload your insurance information to the Service.This Identity Data is stored by our Service, which offers you tools, consistentwith your permissions and preferences, for you to disclose this information tothird parties. This Identity Data is not processed for any purpose other thanfor operation of the Service, the disclosures you authorize, and subject to Your Rights & Choices, in connection with Audit Logs and Information Security.
Subject to Your Rights & Choices, and where permitted by law, we may also use Identity Data andContact Data in connection with Marketing Communications, Product and ServiceImprovement, and Information Security.
Data: Our Service allows AuthorizedUsers, consistent with their permissions and subscription status, to contact ourcustomer support agents. When you contact us, our Service will process Identity Data, Device Data, aswell as any User Content you choose to provide.
Uses: Subject to Your Rights & Choices, ourService will process any Personal Data collected from our communication functionality(via text, chat, email or phone) in order to respond to your request, provideyou with relevant information, or if appropriate, and in connection with Marketing Communications, Product and ServiceImprovement, and Information Security.
Data: Our Service may process IdentityData, Contact Data, and User Content when you contact us through theCorporate Site.
Uses: Subject to Your Rights & Choices, our Service will processany Personal Data we collect from our "contact us" form to respond to yourrequest, provide you with relevant information, or if appropriate, inconnection with Marketing Communications, Product and Service Improvement, and Information Security.
Data: Our Service mayprocess Identity Data and Contact Data in connection with email andsocial media marketing communications if you register for an RK360 Record, chooseto receive marketing communications or interact with our marketingcommunications.
Uses: Our Service processesIdentity Data and Contact Data as necessary to provide marketing communicationsyou request, and consistent with our legitimate business interests, we may sendyou certain marketing and promotional communications if you sign up for thosecommunications or register for our Service. See Your Rights & Choices for information about how you canlimit or opt out of this processing.
Data: Our Service,and certain third parties, mayprocess Identity Data, Contact Data and Device Data when you interactwith cookies and similar technologies on our Corporate Site. Our Service mayreceive this data from third parties to the extent allowed by the applicablepartner. Please note that the privacy policies of third parties may apply tothese technologies and information collected.
(ii) for "analytics" purposes, consistent with our legitimate interests in howthe Corporate Site is used or performs, how users engage with and navigatethrough the Corporate Site, what sites users visit before visiting ourCorporate Site, how often they visit our Corporate Site, and other similarinformation.
Note: Some of these technologies maybe used by us and/or our third-party partners to identify you across platforms,devices, sites, and services.
Subject to Your Rights & Choices, we mayalso process any Personal Data we possess in order to monitor the use of ourService and Corporate Site for malicious activity, detect systemsvulnerabilities, and as otherwise appropriate to maintain the integrity andsecurity of our Service and Corporate Site and the Personal Data we process.
Subject to Your Rights & Choices, we may process any Identity Data, Contact Data, Financial Data, Device Data, and User Content in order to analyze how users interact with our Serviceor Corporate Site, in connection with market research, for product and Serviceimprovements, and as necessary to monitor and maintain the integrity andsecurity of our Service, Corporate Site and the data we process.
We may also process and disclose yourPersonal Data for uses related to medical research, public health, productrecalls and other medical product liability/safety matters, and for otherresearch and public health/safety grounds, to the extent and under theconditions allowed by applicable law.
Ifwe process Personal Data in connection with our Service or Corporate Site in a way not described in this Policy,this Policy will still apply generally (e.g. with respect to Your Rights & Choices) unless otherwise stated when youprovide it.
Notethat we may, without your consent, also process your Personal Data on certainpublic interest grounds. For example, we may process information as necessaryto fulfill our legal obligations, to protect the vital interests of anyindividuals, or otherwise in the public interest. Please see the Data Sharing section for more information about how we disclosePersonal Data in extraordinary circumstances.
ARecord Administrator, whether appointed by the Record Owner or acting aspersonal representative, guardian or medical power of attorney for the RecordOwner, may have access to any Personal Data in the RK360 Record of the RecordOwner, including Medical Records and Medical Profile Data. Record Administratorsmay also disclose that information to third parties or grant access to othersubordinate Authorized Users, to the extent such functionality is madeavailable through the Service and the Record Administrator is appropriatelyauthorized.
To the extent we processpersonal data subject to the Health Insurance Portability and Accountability Actof 1996 (HIPAA), we may disclose such Health Record Data and Health ProfileData, Contact Data, Identity Data, and Insurance Data where authorized for Treatment,Payment, and Healthcare Operations. These include activities such as disclosinginformation to Providers, for our Product and Service Improvement, or if necessary to billpatients or insurance providers.
In connection with our general businessoperations, product/service improvements, to enable certain features, and inconnection with our other legitimate business interests, we may share anyPersonal Data with service providers or subprocessors who provide certainservices or process data on our behalf.
In order to streamline certain businessoperations and develop products and services that better meet the interests andneeds of our Users, and inform our customers about relevant products and services,we may share your Personal Data with any of our current or future affiliatedentities, subsidiaries, and parent companies.
Any Personal Data may be processed withoutyour consent in the event that we go through a business transition, such as amerger, acquisition, liquidation, or sale of all or a portion of our assets.For example, Personal Data may be part of the assets transferred, or may bedisclosed (subject to confidentiality restrictions) during the due diligenceprocess for a potential transaction.
In limited circumstances, we may, withoutnotice or your consent, access and disclose your Personal Data, anycommunications sent or received by you, and any other information that we mayhave about you to the extent we believe such disclosure is legally required, toprevent or respond to a crime, or for other law enforcement and nationalsecurity reasons, to investigate violations of our Terms of Service, or whenthe disclosure is in the vital interests of us or any person. Note, these disclosures may be madeto governments or other authorities in jurisdictions that do not ensure thesame degree of protection of your Personal Data as your home jurisdiction. Wemay, in our sole discretion (but without any obligation), object to thedisclosure of your Personal Data to such parties on any lawful grounds we mayhave.
We may disclose any Personal Data withoutyour consent on certain public interest grounds. For example, we may processinformation as necessary to fulfil our legal obligations, for public health andother matters in the public interest, to medical providers or healthcareorganizations, medical examiners, in connection with organ and tissue donorrequests, or where otherwise allowed by applicable law.
Applicable law may grant you some orall of the following rights in your Personal Data. To the extent applicable lawgrants you these rights, you may exercise these rights using the methods setforth below, or by contacting us. Please note: we may require that youprovide additional Personal Data to exercise these rights, e.g. Identity Datathat is necessary to prove you are authorized to make a request.
Access: You may access the Personal Data thatwe process to the extent required and permitted by law. Further, our Serviceoffers you tools (e.g. through the account services menu), consistent with yourpermissions as a User, for securely accessing your personal data, includingHealth Records, Health Profile Data, data from Audit Logs, and otherinformation about your RK360 Record.
Rectification: Our Service offers you tools, consistent with your permissionsas a User, for correcting any Personal Data that the Service holds about you tothe extent required and permitted by law. You may be able to make changes to PersonalData, such as Account Registration Data and Medical Profile Data through theuser account settings menu provided through the Service.
Pleasenote: Our Service stores and displays copiesof Health Records that are maintained in Providers' systems; we do not controland cannot alter the content of your Health Records. Please contact therelevant Provider to exercise your right to correct Health Records. UpdatedHealth Records will be reflected in the Service when updated by the Providerand only if the Service is authorized to receive the updated Health Record.
Erasure: Our Service offers you tools,consistent with your permissions as a User, for deletion of Health Records,Health Profile Data, account registration data and contents of RK360 Records. Youmay not, however, delete the Audit Logs that document User activities on theService and in RK360 Records. We will explain how to use these tools but cannotutilize these tools on your behalf.
Pleasenote: we store and display copies of HealthRecords that are maintained in Providers' systems if they are shared with us;we do not control and cannot delete Health Records stored in Providers' systems.Please contact the relevant Provider to exercise your right to delete yourprimary Health Records.
Data Portability: To the extent required by applicable law, our Service will enable youto export and send to yourself, to Providers or to other third parties, copiesof certain Personal Data in your RK360 Record in a common portable format ofour choice. Before you delete Data, our Service will remind you to export acopy of your Data to a destination storage location you control. To exportdata, you may use the data sharing functionality that our Service offers andyou may employ as destinations your personal email or fax, or the email or faxof the appropriate third party. We will explain how to use these tools butcannot utilize these tools on your behalf.
Complaints: You have the right to contact or filea complaint with us, as well as regulators or supervisory authorities, aboutour processing of Personal Data. To file a complaint with us, simply contact us. To file a complaint with governmental bodies, pleasecontact your local data protection or consumer protection authority. In the US,you may be able to file a complaint with the Federal Trade Commission, or ifappropriate, the Department of Health and Human Services, in each case, bysubmitting a complaint through their online complaint processes. We will notretaliate against your for filing a complaint.
California Rights: Residents of California (and others to the extent required byapplicable law) may request a list of Personal Data we have disclosed about youto third parties for directmarketing purposes during the preceding calendar year (if any). Please contact us to make this request.
HIPAA: To the extent required by applicable law, we will provideyou with an accounting of the disclosures of your Health Data or Health ProfileData (if any). To do so, please contact us.
Data Collection &Sharing: You may generally control how PersonalData is shared with us, and how we share your Personal Data. You can controlwhat Personal Data we collect by modifying your permissions with your Providers,or modifying your authorizations to share data with third parties. Additionally,you may change your authorization for our Service to receive continuous updatesof your Health Records through the account settings menu. You may also limitsharing of any Health Records and Health Profile Data, as well as any otherPersonal Data (including data shared with third parties and subordinate Users) throughthe account settings menu. Note, only Account Administrators may directly limitthe rights and permissions of subordinate Users. You may contact us for guidance about how to employ the account settingsmenu.
Consent: If you consent to any other processing ofyour Personal Data, you may withdraw your consent at any time. Please note, asthe primary function of the Service is to collect, aggregate, store and sharecopies of your Health Records and Health Profile Data, your sole means ofrevoking consent may be to delete data from the Service, or delete youraccount.
Direct Marketing: You may have alegal right not to receive such messages in certain circumstances, in whichcase, you will only receive direct marketing communications if you consent. Youhave the choice to opt-out of or withdraw your consent to direct marketingcommunications you receive. You may exercise your choice via the links in ourcommunications or by contacting us re:direct marketing.
We are required by law to maintain theprivacy of your Health Records and Health Profile Data, and we implement reasonableand appropriate security measures to safeguard the Personal Data you provide us.However, we sometimes share Personal Data with third parties as noted above,and we do not have control over third parties' security processes. Further,certain methods of sharing your Health Records you may choose to use maypresent risks to the confidentiality of Sensitive Personal Data. We do notwarrant perfect security and we do not provide any guarantee that your PersonalData or any other information you provide us will remain secure, nor will we beliable for any unauthorized disclosures that occur following your choice toshare Personal Data with Authorized Users or recipients you designate, such as Providers.We will notify you if there is a breach of the security of unsecured PersonalData we may process, where such notice is required by law.
OurService keeps the Medical Records and Profile Data of Authorized Users untilthose Users employ the tools the Service offers, consistent with theirpermissions, to delete that data at which point we retain only Audit Logs ofUser activity in accordance with Your Rights & Choices. Otherwise, our Service retainsPersonal Data for so long as it, in our discretion, remains relevant to itspurpose, and in any event, for so long as is required by law. To the extent ourService retains any Personal Data, we will review retention periodsperiodically, and may pseudonymize or anonymize data held for longer periods,if appropriate.
Our Service and Corporate Site are neitherdirected at nor intended for use by minors under the age of majority in therelevant jurisdiction. Further, we do not knowingly collect Personal Data from suchindividuals unless we receive the consent of the minor's parent or guardian. Ifwe learn that we have inadvertently done so, we will promptly delete it. Do notaccess or use the Service or Corporate Site if you are not of the age ofmajority in your jurisdiction unless you have the consent of your parent orguardian.
We operate in and use Internet service providerslocated in the United States. If you are located outside the U.S., yourPersonal Data may be transferred to the U.S. The U.S. does not provide the samelegal protections guaranteed to Personal Data in the European Union.Accordingly, your Personal Data may be transferred to the U.S. pursuant to the EU-U.S.Privacy Shield Framework, the Standard Contractual Clauses, or other adequacymechanisms, or pursuant to exemptions provided under EU law. Contact us formore information regarding the specific mechanism used to ensure adequateprotection of Personal Data subject to EU Law.
Prosocial Applications, Inc. is the data controller for PersonalData collected under this Policy.
The legalbases of our processing of your Personal Data is described in the table below.If you have questions about the legal basis of how we process your PersonalData, contact us at privacy@redkangaroo.us.
Processing is necessary to perform the contract governing our provision of the Service or to take steps that you request prior to signing up for the Service. This may include processing that is necessary to provide the Service.
To secure our platform and network, investigate suspicious activity or violations of our terms or policies; and to protect the safety of Personal Data, including to prevent exploitation or other harms to which Users may be particularly vulnerable.
Processing is necessary to comply with our legal obligations, for example, tax laws, fraud reporting, etc.
Note, we may process and disclose Personal Data where it is in the vital interests of a data subject, to comply with a legal obligation to which we are subject, in the public interest, for public health purposes and medical or scientific research, or other appropriate legal ground which may apply under applicable law.
Right to Object: Where weprocess data on the basis of our legitimate interests, you can object to thatprocessing to extent allowed by law. Note that we must only limit processingwhere our interests in processing do not override an individual's interests,rights, and freedoms, or the processing is not for the establishment exercise,or defense of a legal claim.
Right to Restrict: You may have the restrictprocessing of your Personal Data where the accuracy of the Personal Data iscontested, the processing is unlawful but you object to deleting the PersonalData, or we no longer require the Personal Data, but it is still required forthe establishment, exercise, or defense of a legal claim, or while we assess anobjection to processing.
We are required to complywith the effective version of this Policy. We may change this Policy from timeto time, and when we do so, the changes will apply to all Personal Data wemaintain, to the extent allowed by applicable law. Changes will be posted onthis page with the effective date. Please visit this page regularly so that youare aware of our latest updates. Your use of the Service following notice of anychanges indicates acceptance of any changes. You may download and print a papercopy of this notice from the Corporate Site.
Feel free to contact us with questions orconcerns using the appropriate address below.


An immaculate example. 18ct yellow gold Cartier Tankissime watch, quartz movement. Factory round brilliant diamond set case. Original Cartier box and with Cartier service papers. Lanes pre-owned watches are accompanied with a full 12 month warranty. If you require any further information please do not hesitate to contact our helpful team.
All watches listed by Lanes are physically in stock and available to view by appointment. Please enquire or visit us in-store.
Free next working day delivery on all items when ordered before 2pm.
All orders come with complimentary luxury packaging.
Collect your purchases in store at Lanes Jewellery boutique in Holt, Norfolk.
If you wish to return an item, we offer a 14-day returns period from your purchase date.
Lanes offer a 12 month warranty on all items.
0% finance is available on new items of jewellery over £1000.
At Lanes, all our pre-owned watches undergo thorough inspection of condition, accuracy, functionality and water resistance by highly trained and skilled accredited watchmakers, ensuring our strict standards are met.
Michael and Josh Lane are avid watch fans and will jump at the chance to talk watches and answer any questions or queries you may have.


Need a packable down jacket? The Eddie Bauer Cirruslite 2.0 Down Parka is perfect for travel because it has a built in stuff sack and packs down to the size of a Nalgene bottle. It might not get you through the Polar Vortex at -50 degrees, but it is rated to -20, which is pretty cold. I would layer with another down coat for temps that low. You can layer down–I got the idea in Canada when I saw someone on the train layering down jackets, and she didn't look like the Michelin Man. It looked so cute, I've been doing it ever since, with thinner down. Boy does that keep you toasty.
I think the Eddie Bauer Cirruslite 2.0 Down Parka best suited for temps in the range of 40-30 degrees, but I am a wimp in the cold and like to bundle up. It's been in the 30's where I live and it's fine for that, but I still need accessories like gloves and hat and warm layers underneath. This coat is really nice for when you're traveling to places with big temperature jumps and unpredictable weather. You can fit it in your daypack, and it doesn't take up too much space in your luggage the way a lot of down coats would.
Because it's not super puffy, it's flattering, with seams that give the coat nice lines and compliment your figure. It's also very soft, the fabric is Poly with StormRepel DWR to repel moisture. It has an inner zip pocket for your credit card and id, and two side pockets. All Eddie Bauer down is RDS Certified down, ie Responsible Down Standard, meaning all their down is humanely sourced. Find the Eddie Bauer Cirruslite 2.0 Down Parka HERE.


text:
Adrenaline, (Nor-)
Adrenoceptor β3
Mirabegron
Mirabegron - YM 178 | Betanis
MF C21H24N4O2S
Highly selective and orally active agonist of the human β3-adrenoceptor (EC50 value 22.4 nM) with >440 fold selectivity over β1, and β2. FDA approved therapeutic drug for the treatment of symptoms of overactive bladder such as urinary frequency, urgency, and urge incontinence. YM178 (Mirabegron) does not affect the amplitude of rhythmic bladder contractions at doses at which it reduces contraction frequency.
T. Takasu et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function. J Pharmacol Exp Ther. 2007 May;321(2):642-7.
E. Sacco et al. Mirabegron: a review of recent data and its prospects in the management of overactive bladder. Ther Adv Urol. 2012 Dec;4(6):315-24.
N. Aizawa et al. Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin. Eur Urol. 2012 Dec;62(6):1165-73.
Cardiovascular CNS A17 Adrenoceptor β3
Highly selective and orally active agonist of the human β3-adrenoceptor
(R)-2-(2-aminothiazol-4-yl)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)acetamide
1138 Mirtazapine 5-HT antidepressant €65.00
1154 B-HT 933 dihydrochloride α2 adrenoceptor agonist €115.00
1155 Efaroxan hydrochloride α2 adrenoceptor antagonist €65.00
1157 Bromobuterol β2 agonist €85.00
1159 Celiprolol hydrochloride β1 antagonist €135.00
1269 SSR 69071 HLE inhibitor €145.00
1290 ST 91 α2 adrenoceptor agonist €80.00
1371 Atipamezole hydrochloride α2 adrenoceptor antagonist €95.00
1518 Timolol maleate β1 adrenergic antagonist €80.00
1555 Brimonidine tartrate α2 adrenoceptor agonist €70.00
1750 MIBG hemisulfate Radiopharmaceutical; Noradrenaline analogue €115.00
2040 Prazosin hydrochloride Peripherally acting α1 adrenoceptor antagonist €50.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
1519 Sunepitron hydrochloride Anxiolytic and antidepressant drug €140.00
3488 (±)-CGP-12177A β1/β2 adrenoceptor antagonist, β3 adrenoceptor agonist Recently added €120.00


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(Redirected from Resistance)
WikiDoc Resources for Drug resistance
Most recent articles on Drug resistance
Most cited articles on Drug resistance
Review articles on Drug resistance
Articles on Drug resistance in N Eng J Med, Lancet, BMJ
Powerpoint slides on Drug resistance
Images of Drug resistance
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Podcasts & MP3s on Drug resistance
Videos on Drug resistance
Cochrane Collaboration on Drug resistance
Bandolier on Drug resistance
TRIP on Drug resistance
Ongoing Trials on Drug resistance at Clinical Trials.gov
Trial results on Drug resistance
Clinical Trials on Drug resistance at Google
US National Guidelines Clearinghouse on Drug resistance
NICE Guidance on Drug resistance
FDA on Drug resistance
CDC on Drug resistance
Books on Drug resistance
Drug resistance in the news
Be alerted to news on Drug resistance
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Risk calculators and risk factors for Drug resistance
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List of terms related to Drug resistance
Drug resistance is the reduction in effectiveness of a drug in curing a disease or improving a patient's symptoms. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. More commonly, the term is used in the context of diseases caused by pathogens.
Pathogens are said to be drug-resistant when drugs meant to neutralize them have reduced effect. When an organism is resistant to more than one drug, it is said to be multidrug resistant.
Drug resistance occurs in several classes of pathogens:
bacteria -- antibiotic resistance
endoparasites
viruses -- resistance to antiviral drugs
cancer cells
The most prominent is antibiotic resistance. Drug resistance is also found in some tumor cells, which makes it more difficult to use chemotherapy to attack tumors made of those cells. Resistance to antiviral drugs also occurs in virus populations, notably HIV. When a drug is administered, those organisms which have a genetic resistance to the drug will survive and reproduce, and the new population will be drug-resistant (see natural selection, selection pressure).
In the presence of drugs, pathogens have evolved sophisticated mechanisms to inactivate these compounds (e.g. by pumping out compounds, mutating residues required for the compound to bind, etc.), and they do so at a rate that far exceeds the pace of new development of drugs. Examples include drug resistant strains of Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa, and Mycobacterium tuberculosis (TB) among bacterium and HIV-1 among viruses. Indeed, no new antibiotics have been developed against TB in thirty years. Efforts to develop new antibiotics by the pharmaceutical industry by large-scale screens of chemical libraries which inhibit bacterial growth have largely failed, and new tetracycline and sulfanilamide analogs will likely engender resistance and will quickly be rendered useless. The resistance problem is compounded further by indiscriminate and inappropriate use of antibiotics and anti-viral compounds without compliance measures or public health policies to reduce disease burden. Finally, with current legislative restrictions, the very high costs associated with clinical trials (e.g. ~$400M to bring new tetracyclines to market for an expected revenue of ~$100M), the failure to control generic sales, and the capacity to generate substantial revenues from medications for chronic illnesses, there is little if any financial incentive for big pharmaceutical companies to even develop new antibiotics, and small biotech companies simply do not have the resources. The search for novel anti-viral compounds has been somewhat more successful and largely motivated by the AIDS epidemic, but drugs have been developed principally against viral targets, and mutation rates among viruses still outpaces new development. One positive development has been vaccines, which are promising for some bacterial and viral illnesses. But vaccines are not successful in all cases (e.g. in young children), and adequate resources have not been made available.
Metabolic price
Biological cost or metabolic price is a measure of the increased energy metabolism required to achieve a function.
Drug resistance has a high metabolic price,[1] in pathogens for which this concept is relevant (bacteria[2], endoparasites, and tumor cells.) In viruses, an equivalent "cost" is genomic complexity.
↑ The biological cost of antimicrobial resistance Stephen H. Gillespie*, and Timothy D. McHugh
↑ Wichelhaus TA, Böddinghaus B, Besier S, Schäfer V, Brade V, Ludwig A (2002). "Biological cost of rifampin resistance from the perspective of Staphylococcus aureus". Antimicrob. Agents Chemother. 46 (11): 3381–5. doi:10.1128/AAC.46.11.3381-3385.2002. PMID 12384339. CS1 maint: Multiple names: authors list (link)
BURDEN of Resistance and Disease in European Nations - An EU-Project to estimate the financial burden of antibiotic resistance in European Hospitals
et:Ravimresistentsus it:Farmaco-resistenza
Template:WikiDoc Sources Template:Jb1
Retrieved from "https://www.wikidoc.org/index.php?title=Drug_resistance&oldid=1136398"
This page was last edited 14:00, 20 August 2015 by Jyostna Chouturi. Based on work by wikidoc user WikiBot.


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PROJECT : ENCORE™
A Catalog of Contemporary Choral Music
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Akmal Parwez
Composer-vocalist Akmal Parwez was born into a musical and artistic family in Punjab, Pakistan. His father was the renowned poet, music scholar and journalist, Afzal Parwez. He studied electronics in Tokyo on a Japanese government scholarship, receiving B.E. and M.E. degrees. However, after a brief engineering career, and encouraged by his composition teachers Yasushi Akutagawa and Klaus Pringsheim, he felt compelled to devote his life to composing, singing, and teaching music.
He came to the U.S. to study voice with Joseph Klein and later studied composition with Florence Jolley, Leo Kraft, Samuel Adler, Warren Benson, and Joseph Schwantner. He received an M.A. in Composition from Queens College and a Ph.D. in Composition from the Eastman School of Music.
Parwez is a bass-baritone soloist, choral conductor, and voice teacher who often performs his own works. His music, which is a romantic and uniquely dynamic synthesis of Eastern and Western compositional techniques, has been extensively performed—and well received—throughout the U.S. as well as in Europe and Asia. Winner of the William Cullen Bryant Bicentennial Composition Prize for his Song of the Prairies*, Parwez has received a SUNY Award for his Pneumatic Polychrome for Symphonic Wind Ensemble and ASCAP Standard Awards annually since 1984, several grants from Meet the Composer, four Composer Assistance Program Grants from the American Music Center—for his Chenab (premiered by the Queens Symphony Orchestra) NavRasa (Nonet for W/W Quintet & String Quartet), Ragalogues (Woodwind Quintet), and Once Upon a Springtime (Flute & Bassoon Soloists & Wind Ensemble)—as well as grants from the Queens Council on the Arts, the Huntington Arts Council, and an Honorable Mention in the 1983 George Eastman Prize Competition for his Tantra for Bassoon and Harp. His music is published by Tamarind Tones Music
Parwez has taught at the Malaysian Science University, Penang, as well as at SUNY-Potsdam, NYU, Hofstra, Queens College, and the Japanese School of New York.
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GermanyinUSA – @GermanyinUSA
Author: GermanyinUSA
The Legend of Saint Nicholas
© dpa / picture-alliance
"Ho, ho, ho, have you all been good?" The old man with a long white beard, a bishop's miter, and a thick red cape stands with his finger raised before the excited children, his eyes moving from one beaming face to the next.
"Yes!" they all shout in unison, impatiently eyeing the heavy brown sack that Saint Nicholas has carried in from the cold night over his shoulder. What could it possibly hold? Toys, books, or even candy? "Well, that's good to hear!" Nicholas declares and opens his big golden book, from which he reads the names of the children and presents each of them with a small gift from his sack. They politely thank him, offer homemade cookies to
their peculiar guest, and recite small poems. Finally, they accompany him to the door, where he trots off with a jolly "ho, ho, ho," disappearing into the dark on his way to the next house.
Diverse origins
Such a visit is not at all unusual in Germany in the pre-Christmas season, for every year on December 6 Saint Nicholas is remembered and celebrated in this way. Like many traditions handed down over the centuries, it is unclear what is true and what has been added over time to the legend of Saint Nicholas.
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Author GermanyinUSAPosted on December 5, 2018 November 30, 2018 Categories CultureTags Saint NicholasLeave a comment on The Legend of Saint Nicholas
2018 Campus Weeks "Homestory: Deutschland" at Morgan State University
Pieces of the "Homestory: Deutschland" exhibition as shown at Morgan State University
Students and faculty of Morgan State University filed into the auditorium of the university's new Behaviorial and Social Science Center on October 16 for the first of several events associated with the 2018 Campus Weeks Homestory: Deutschland exhibit. The small but powerful exhibit, produced by the Initiative of Black Germans (Initiative Schwarze Menschen in Deutschland e.V. – ISD-Bund e.V. by its German acronym), chronicles experiences of people of color in Germany from the early 19th century to recent years. It is being shown at Historically Black College and Universities this fall as part of the 2018 Campus Weeks project.
Dr. Fatima El-Tayeb, Professor of African-American Literature and Culture and Director of Critical Gender Studies and on the affiliated faculty for the Department of Ethnic Studies at the University of CA at San Diego, gave a lecture titled "Homestory Deutschland: On the (Im)possibility of being Black and German."
Dagmar Schulz's film, "Audre Lorde: the Berlin Years," was followed by a lively discussion led by Morgan State professors, Dr. Sandra Skene (Gender Studies) and Dr. Jewel Debnam (History). High school students from Baltimore Polytechnic Institute joined Morgan students for a round table discussion on "The African-American Scholar in Germany: a Morgan Perspective." Dr. Zekeh Gbotokuma from the Department of Philosophy moderated the panel, which included four Morgan students who had studied in Berlin.
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Author GermanyinUSAPosted on November 14, 2018 November 14, 2018 Categories EventsTags Homestory DeutschlandLeave a comment on 2018 Campus Weeks "Homestory: Deutschland" at Morgan State University
Intern Q&A: Clemens Schleupner
Name: Clemens Schleupner
Where you're from: I'm from a little town near Düsseldorf, called Willich.
Where and what you're studying: I'm studying International Relations at Sciences Po Paris.
What is one project or activity you enjoyed at the Embassy? Organizing the EU Open House was certainly my highlight. I got to work with a wonderful team, take responsibility, make mistakes and learn a lot. It was a very intense project, but it's safe to say that I have never seen anything more rewarding than 7000 happy visitors in the embassy.
What do you think is one of Germany's main foreign policy challenges and what should Germany do about it? With political shifts abound, Germany needs to step up and take responsibility in the world. It needs to shape its opinion on issues like the future of the EU and stand for values like integrity and consistency in order to find its place in these challenging times.
What are some cultural impressions you gained of the United States? I've lived in DC before, but working in the embassy has made American optimism and the energy of Americans even more apparent to me. It was interesting to see Americans and Germans work together so closely, with all the cultural differences and similarities. I believe that combining both points of views can be nothing but beneficial to any project.
What has been your biggest surprise with regard to living in Washington? Even though I've known many corners of DC, I was surprised by how this city always has something new and exciting to offer. I kept discovering new places and activities. After long days in the embassy for example, I appreciated all the green and open spaces that gave me the opportunity to recharge my batteries.
What do you miss about Germany? This summer in particular I missed the German Soccer culture. Regarding our team's performance, I wish I could have yelled more at the TV without being looked at weirdly.
What has been your biggest lesson learned during your internship? Taking responsibility helps you grow. I wouldn't have thought that I'd be capable of taking on a major role within such a talented and well-functioning team, working on such a big project as the EU Open House.
What has been your biggest challenge living here? Saying goodbye to this job and all the friends I've made. It was equally hard and exciting to see my fellow interns come and go, to constantly meet new people, and to now finally leave this place with all the great memories that I've made. Looking back will probably be the biggest challenge yet to come.
Where do you plan to go or what do you plan to do after your internship? I'm going to pursue my Master's degree in International Public Management at Sciences Po Paris.
Author GermanyinUSAPosted on July 25, 2018 July 20, 2018 Categories Intern BlogTags Intern, intern blog, Intern Q&A, internship, internshipsLeave a comment on Intern Q&A: Clemens Schleupner


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Clean energy catalyst program announces funding awards
The program supports clean energy innovation and technology development across Massachusetts. Here are some of the recent cash awardees in solar and energy storage.
August 31, 2021 Ryan Kennedy
Rooftop solar in Boston.
Image: NREL/SunPower
Massachusetts announced a $2.6 million funding program managed by the Massachusetts Clean Energy Center (CEC), MassVentures, and the InnovateMass program, to support clean energy innovation.
The programs aim to ensure early-stage ventures have the resources to advance critical technologies toward marketable products.
The recently announced PV and storage awardees include:
Sol Clarity – Auburndale, MA: Awarded $65,000 for the development of an automated solar panel cleaning product. The Boston University-born project utilizes a small amount of electricity to statically remove dust and soiling from solar panels.
The panel's surface is charged up to 1200 volts, which moves through three thin fingers, each of a different phase. The alternating phase layers cause the energy to move through the surface as waves, thereby pushing the dust off the panel. Sol Clarity said the power used is a capacitive load, not a resistive one, meaning very little power is used.
Worcester Polytechnic Institute – Worcester, MA: Awarded $65,000 to support a researcher's sensor and software system for maximal localized solar generation. The researcher is developing an intelligent cloud motion vector sensor, to detect clouds by implementing machine learning techniques. The aim is to improve short-real-time forecasting of PV system performance as a function of moving clouds.
Vespr V-Clamp for weather resistance.
Image: Vespr Solar
Vespr Solar – Somerville, MA: Awarded $65,000 to test a hurricane-resilient solar panel attachment. The clamp system can be installed beneath modules, with no need for power tools in installation, said Vespr. The company said full panel install can occur in less than 30 seconds per module, and grounding and attachment are completed in a single step. The "V-Clamp" can withstand 900 Lbf for uplift force, and meets NASM 1312-7 vibration standards.
Nth Cycle – Beverly, MA: Awarded $250,000 for the development of cost-effective recycling of metals from lithium-ion batteries. The company uses electro-extraction to recover critical materials from the batteries. Conventionally, these materials are recovered using pyrometallurgy or hydrometallurgy. Pyrometallurgy uses large, carbon-emitting furnaces that consume large amounts of energy, said Nth Cycle. And hydrometallurgy requires the use of harmful acids and solvents that create large masses of environmentally destructive chemical waste. Nth Cycle said the use of electricity in its novel extraction process is clean and modular, making it a more sustainable option.
(Read: "Recycling: a key in the U.S. quest for lithium-ion battery supply chain relevancy")
The CEC Catalyst fund also provided funds to organizations working on innovations in transportation, maritime shipping, offshore wind, biomass, heating and cooling, energy efficiency, and more.
Since 2010, the CEC Catalyst fund has awarded $7.2 million to 138 new companies and research teams. Past awardees have raised over $244 million in follow-on funding.
InnovateMass has awarded over $8.5 million in funding for demonstration projects since 2013, and leveraged over $10 million in private and public investments in the space. Follow-on investments for these awardees totaled $107 million.
Ryan Kennedy
Ryan joined pv magazine in 2021, bringing experience from a top residential solar installer, and a U. S.
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This June our Akira Kurosawa film club becomes a drama club as we read Anton Chekhov's play A Marriage Proposal, which Kurosawa directed for stage following the release of Drunken Angel in 1948.
Chekhov's A Marriage Proposal (Предложение, sometimes also translated as simply Proposal) is a fairly short single-act farce written in the late 1880s and first staged in 1890, which is also roughly when the picture of him that I have here was taken. Wikipedia has more information about the play.
The text is available in English for free as part of Project Gutenberg's Plays by Anton Chekhov collection, as well as at One Act Plays. Note that in case you have an ebook reader, Gutenberg offers the text in formats including ePub and Kindle, in addition to html and plain text.
For those of you who signed up for this film club to watch things, not read them, there is at least one production available on YouTube: an Edge Ensemble Studio Showcase in two parts (part 1 and part 2).
Or, if you would rather listen to the play, you can download a reading from Librivox.
Since the play is so short, an additional theme for this month is Kurosawa's Russian influences. So, if you have a Dostoevsky novel sitting on your desk that you have been wanting to read, there is not better time than the present! Let us know if you decide to explore Kurosawa's relationship with Russian authors or film makers and what you find.
In July we continue with The Quiet Duel. For a full Akira Kurosawa film club schedule, see AK Online Film Club.
If this is what the proposal is like, I dread to think of what the marriage would be like.
Do we know anything about who starred in Kurosawa's production of this?
This is, of course, pure speculation.
What do you think interested Kurosawa in the play enough to stage it?
One thing that I noticed was how non-cinematic it is. I don't think that it could work as a film. Maybe Kurosawa chose this piece to take himself out of his own comfort zone?
I was also thinking about the mannerisms of the characters, that particular late 19th century Russian upper class behaviour. Isn't that in some ways quite similar to Japanese customs?
Vili – I wondered if it was a double bill or if he used the same actors for both productions.
I'd have to go back and read the play again to give a definitive answer to why Kurosawa chose it or to evaluate its non-cinematic nature. It is very talky. Perhaps he chose it because of the amount of conflict and the swings in the characters' moods. All that seems fairly typical of Russian literature of the era; I remember encountering, and being somewhat bewildered by, the same things in Dostoevsky's writings. The characters in Gorky's The Lower Depths seem positively even-tempered by comparison. Perhaps their poverty smoothed the sharp edges of their personalities.
I don't know; other than the initial politesse, 19th century Russian upper class behavior seems fairly different from Japanese customs. I don't think the Japanese would be quite so blunt to someone's face. Perhaps if they were speaking to an intermediary they would be.
The mood swings do indeed feel very Kurosawa-like — I can actually almost see Takashi Shimura, a little hunched but devilishly determined, marching up and down the stage as Stepan! I of course have no idea whether that ever happened.