text:
Q: Error: Invalid value for  attribute when passing in variable I was having some problem when trying to zoom to certain point on esri base map with an OneMap map overlayer. Here is the function where I get the coordinates x and y by passing in postal code:
function zoomPostal(postalCode) {
 $.getJSON("http://www.onemap.sg/API/services.svc/basicSearch?token=qo/s2TnSUmfLz+32CvLC4RMVkzEFYjxqyti1KhByvEacEdMWBpCuSSQ+IFRT84QjGPBCuz/cBom8PfSm3GjEsGc8PkdEEOEr" +
        "&searchVal=" + postalCode + "&otptFlds=SEARCHVAL,CATEGORY" +
        "&returnGeom=0&rset=1", function (data) {

     var x =  data.SearchResults[1].X;
     console.log(x);
     var y =  data.SearchResults[1].Y;
     console.log(y);
    var loc = new esri.geometry.Point({
        "x": x,
        "y": y,
        "spatialReference":'PROJCS["SVY21",GEOGCS["SVY21[WGS84]",DATUM["D_WGS_1984",SPHEROID["WGS_1984",6378137.0,298.257223563]],PRIMEM["Greenwich",0.0],UNIT["Degree",0.0174532925199433]],PROJECTION["Transverse_Mercator"],PARAMETER["False_Easting",28001.642],PARAMETER["False_Northing",38744.572],PARAMETER["Central_Meridian",103.8333333333333],PARAMETER["Scale_Factor",1.0],PARAMETER["Latitude_Of_Origin",1.366666666666667],UNIT["Meter",1.0]]' });

    map.centerAndZoom(loc, 5);
        });

}
When I print out the x and y, I am getting 23948.7465 and 47505.7986 so which means it is not NaN or null. However, with these code, I am getting error message as such:
Error: Invalid value for <image> attribute x="NaN"
Error: Invalid value for <image> attribute y="NaN"

The strange thing is if I hardcoded the coordinate x and y to 'x" and "y" in the loc variable, it did zoomed and worked perfectly. I not sure why is it behaved in this way.
Any ideas? Thanks in advance.
EDIT
This is the part where the error message was show:
function zoomPostal(postalCode) {
 $.getJSON("http://www.onemap.sg/API/services.svc/basicSearch?token=qo/s2TnSUmfLz+32CvLC4RMVkzEFYjxqyti1KhByvEacEdMWBpCuSSQ+IFRT84QjGPBCuz/cBom8PfSm3GjEsGc8PkdEEOEr" +
        "&searchVal=" + postalCode + "&otptFlds=SEARCHVAL,CATEGORY" +
        "&returnGeom=0&rset=1", function (data) {

     var x =  data.SearchResults[1].X;
     console.log(x);
     var y =  data.SearchResults[1].Y;
     console.log(y);
    var loc = new esri.geometry.Point({
        "x": x,
        "y": y,
        "spatialReference":'PROJCS["SVY21",GEOGCS["SVY21[WGS84]",DATUM["D_WGS_1984",SPHEROID["WGS_1984",6378137.0,298.257223563]],PRIMEM["Greenwich",0.0],UNIT["Degree",0.0174532925199433]],PROJECTION["Transverse_Mercator"],PARAMETER["False_Easting",28001.642],PARAMETER["False_Northing",38744.572],PARAMETER["Central_Meridian",103.8333333333333],PARAMETER["Scale_Factor",1.0],PARAMETER["Latitude_Of_Origin",1.366666666666667],UNIT["Meter",1.0]]' });
    console.log(loc.x);
    map.centerAndZoom(loc, 5);
        });

}
From these code, I am getting 23948.7465 and 47505.7986 for variable x and y and as well as loc.x when I print them out but the error message was there.
Then, I tried to hardcode the x and y by putting in the value above like this:
 function zoomPostal(postalCode) {
 $.getJSON("http://www.onemap.sg/API/services.svc/basicSearch?token=qo/s2TnSUmfLz+32CvLC4RMVkzEFYjxqyti1KhByvEacEdMWBpCuSSQ+IFRT84QjGPBCuz/cBom8PfSm3GjEsGc8PkdEEOEr" +
        "&searchVal=" + postalCode + "&otptFlds=SEARCHVAL,CATEGORY" +
        "&returnGeom=0&rset=1", function (data) {

     var x =  data.SearchResults[1].X;
     console.log(x);
     var y =  data.SearchResults[1].Y;
     console.log(y);
    var loc = new esri.geometry.Point({
        "x": 23948.7465,
        "y": 47505.7986,
        "spatialReference":'PROJCS["SVY21",GEOGCS["SVY21[WGS84]",DATUM["D_WGS_1984",SPHEROID["WGS_1984",6378137.0,298.257223563]],PRIMEM["Greenwich",0.0],UNIT["Degree",0.0174532925199433]],PROJECTION["Transverse_Mercator"],PARAMETER["False_Easting",28001.642],PARAMETER["False_Northing",38744.572],PARAMETER["Central_Meridian",103.8333333333333],PARAMETER["Scale_Factor",1.0],PARAMETER["Latitude_Of_Origin",1.366666666666667],UNIT["Meter",1.0]]' });
    console.log(loc.x);
    map.centerAndZoom(loc, 5);
        });

}
With these code, the zoom works perfectly without any error.

A: How about this...
function zoomPostal(postalCode) {
 $.getJSON("http://www.onemap.sg/API/services.svc/basicSearch?token=qo/s2TnSUmfLz+32CvLC4RMVkzEFYjxqyti1KhByvEacEdMWBpCuSSQ+IFRT84QjGPBCuz/cBom8PfSm3GjEsGc8PkdEEOEr" +
        "&searchVal=" + postalCode + "&otptFlds=SEARCHVAL,CATEGORY" +
        "&returnGeom=0&rset=1", function (data) {

     var x =  data.SearchResults[1].X;
     console.log(x);
     var y =  data.SearchResults[1].Y;
     console.log(y);
     var initializer = { "x": x, "y": y, "spatialReference":'PROJCS["SVY21",GEOGCS["SVY21[WGS84]",DATUM["D_WGS_1984",SPHEROID["WGS_1984",6378137.0,298.257223563]],PRIMEM["Greenwich",0.0],UNIT["Degree",0.0174532925199433]],PROJECTION["Transverse_Mercator"],PARAMETER["False_Easting",28001.642],PARAMETER["False_Northing",38744.572],PARAMETER["Central_Meridian",103.8333333333333],PARAMETER["Scale_Factor",1.0],PARAMETER["Latitude_Of_Origin",1.366666666666667],UNIT["Meter",1.0]]' }
    var loc = new esri.geometry.Point(initializer);
    console.log(loc.x);
    map.centerAndZoom(loc, 5);
        });
}

redpajama_set_name: RedPajamaStackExchange


text:
Land Dispute | Alleged Murderer injured in road accident
Three alleged murderers on a bike met with an accident near Bedwas - Pratapnagar today afternoon. The three were allegedly part of a Murder plan which was devised to settle a land dispute.
By UdaipurTimes Team Tue, 17 Sep 2019
Three people on a bike met with an accident near Bedwas – Pratapnagar today afternoon. The three were allegedly part of a Murder plan which was devised to settle a land dispute.
A Scooty carrying three people reached Bedwas near Alakh Nayan Mandir Eye Hospital in the afternoon today. The three were carrying swords and other arms with an intention to attack a certain Bhur Singh, in relation to a land dispute. The vehicle slipped on the road and one person was seriously injured while his two accomplices fled from the scene. The swords were also recovered from the site of the accident, which established the purpose with which the trio had approached the area.
CLICK HERE TO READ U D A I P U R T I M E S on your Android device
As per information provided by the police, the three had a land dispute with Bhur Singh, following which they had come to attack Bhur Singh. Bhur Singh was driving a water tanker and the Scooty collided with the tanker and slipped causing the trio to fall down from the vehicle. One of the three was injured seriously and hence could not move, while the other two fled from the spot.
When the police reached the spot, they took the injured attacker to hospital for preliminary treatment and confiscated the arms recovered from the scene of the accident. Bhur Singh, in his statement to the police said that the three were there with an intention to murder him, while the one person injured gave a statement saying that Bhur Singh intentionally collided into the Scooty with an intention to harm them. Police is investigating both the statements before coming to a substantial conclusion.

redpajama_set_name: RedPajamaCommonCrawl


Robert A. Constantino for the defendant.
Anne Christman, Assistant District Attorney, for the Commonwealth.
On December 8, 1984, two Lowell police officers, Hilda Hernandez and Michael Miles, responded to a complaint of a domestic disturbance. It is not necessary to describe the fiery scene (on the government's evidence) that the officers came upon, and by which they were soon enveloped. The relevant consequence, for our purposes, was that the defendant Gonzalez was charged with assault and battery upon Officer Hernandez. A jury of six found the defendant guilty. The principal ground of the defendant's appeal is that her efforts to establish bias on the part of a police witness were improperly thwarted. We affirm.
The defense sought to inquire of Officer Miles concerning a pending civil action against him, arising out of altogether unrelated events, in which the plaintiff complained of police misconduct. An associated question would have required Officer Miles to explain why he had failed to appear on a previously scheduled trial date, March 20, 1985.
370 Mass. 283 , 287 (1976). Commonwealth v. Bucknam, 20 Mass. App. Ct. 121 , 122 (1985). Here the general subject of bias was not barred. See Commonwealth v. Morris, 20 Mass. App. Ct. 114 , 119 (1985). The right to cross-examine to show bias or prejudice is not necessarily infringed by curbing inquiry if the matter sought to be elicited has been sufficiently aired. Commonwealth v. Hicks, 377 Mass. 1 , 8 (1979). By its very nature, the defendant's theory of defense gave vent to the possibility that Officer Miles harbored bias against the defendant. That theory placed the defendant in the role of a victim of unnecessary roughness by the police and sought to characterize the police charge that the defendant struck Officer Hernandez as a contrived, preemptive maneuver. Considering the reciprocal accusations of violence, "the jury could not have nursed the illusion" that either the defendant or the police officer "was a dispassionate witness." Commonwealth v. Bucknam, 20 Mass. App. Ct. at 123. The exclusion of questions about the pending civil action and Officer Miles' absence on March 20 cannot be regarded as having palpably crimped the defendant's efforts to explore questions of the officer's bias.
(2) Link of proffered testimony to bias. Steps taken to pursue civil complaints against police are admissible for purposes of permitting the jury to infer that the police acted in a spirit of retaliation against the defendant. Commonwealth v. Ahearn, 370 Mass. at 286. How an inference of bias was to be drawn from the ground the defendant sought to explore in this case was a great deal less than obvious. The civil complaint adverted to had been brought about a year before the occurrence from which the instant case arose and had nothing to do with the defendant. Still less clear was what the jury were to learn from hearing Officer Miles explain why he was not in court on March 20, 1985. (The Commonwealth said it was simply because an assistant district attorney had mistakenly told him to be present on the 22d.) On appeal, defense counsel offers a nexus he did not make available to the trial judge. It is roughly as follows: were the defendant found not guilty, she would be emboldened to file a complaint alleging misconduct against Officer Miles (although the charge of assault and battery concerned Officer Hernandez); as Officer Miles had been the subject of a complaint in the pending case arising out of the earlier, unrelated, incident, he would wish to avoid affording the defendant a plausible basis for filing what would constitute a second misconduct complaint against him. As the Commonwealth fairly observes, even as elaborated on appeal, the inferences the defendant says can be drawn are convoluted. When the relevance or purpose of a line of questioning is unclear, the cross-examiner has the obligation to make some explanation as to how the answer of the witness will show bias. Commonwealth v. Cheek, 374 Mass. 613 , 615 (1978). Commonwealth v. Bucknam, 20 Mass. App. Ct. at 122. Contrast Commonwealth v. Ahearn, 370 Mass. at 286. Certainly when the evidence of bias is as attenuated as here, the discretion of the trial judge in ruling on its admission is broad. Commonwealth v. Dominico, 1 Mass. App. Ct. 693 , 714-715 (1974). Commonwealth v. Bucknam, 20 Mass. App. Ct. at 123.
(3) Chastisement of defense witness. There were occasions at trial upon which the trial judge attempted to rein in witnesses who volunteered unresponsive answers. In the case of one defense witness, Louis Kliros, there were several such warnings. The degree to which Kliros roved beyond the scope of questions put to him was egregious. The record reflects that the judge was even-handed in his curtailing of witnesses. He was not unkind or overbearing and sought repeatedly to explain to witnesses the confines imposed by the rules of evidence and courtroom decorum. We do not think his remarks reflected on the credibility of defense witnesses. There was no error.


The Board of Elections registers all eligible citizens to vote, provides free voter ID's, and maintains district maps for Cook County. We also conduct all Federal, State and County wide elections, maintain election results, and uphold election laws regarding registration and voting.
Please Note: The list of Election Events must be set in advance by the Georgia Secretary of State. It does not mean that all events listed will happen. Any Election Event for Cook County will be published in the Adel News Tribune and on the Public Notices page on the county website.
Was my Provisional Ballot counted?
The Secretary of State's Office has also established a secure website and free-access telephone number for provisional ballot voters to access to determine whether their provisional ballots were counted and if not, the reason why.
The free access number is (844) 537-5375.


Support from an amazing teacher from a nearby private school, Pie Blight, who is uplifting the education and facilities at the school.
Another favourite project is when guests visit the school and see a need to which they would like to respond with a donation. We recently received a visit from the Boedrich family who brought a much-appreciated donation of books to the school. Harald then took the time to send us this letter and some photographs of their visit. Thank you Boedrich family for your care.
During our stay at Thonga Beach we had the opportunity to visit Mabibi Primary School and hand over some books to the Principal.
We appreciated the Cultural Tour very much. It was a great experience for all of us: My wife is a teacher (biology and chemistry, High School), my son is a pupil (in High School) and I listen every evening to their events of the day. So school is very dominant in our daily life. Thank you very much for this insight!


text:
7 A.I. Marketing Tools That Will BLOW YOUR MIND
by Neil Patel
Seven AI marketing tools that'll blow your mind. If you thought that only your grandchildren will see AI dominating areas that humans could, well, think again, because there's some really cool tools that you need to check out. Over the last few years, the development of AI has skyrocketed. Tasks that would take you hours to complete can now be done in minutes automatically.
RESOURCES & LINKS:
CopyAI: https://www.copy.ai/
Beautiful.ai: https://www.beautiful.ai/
Profile Picture Maker: https://pfpmaker.com/
Brandmark.io: https://brandmark.io/
Oribi.io: https://oribi.io/
Synthesia.io: https://www.synthesia.io/
Unscreen.com: https://www.unscreen.com/
In marketing, there are already quite a few things that you can do much faster. There's a quote by Larry Page, one of the founders of Google that says, "Artificial intelligence would be the ultimate version of Google. The ultimate search engine that would understand everything on the web. It would understand exactly what you wanted, and it would give you the right thing." The global artificial intelligent market size will grow from 93.53 billion in 2021 to 997 billion in 2028. That's almost a trillion dollars. That's pretty much 10x.
So how can you harness the power of these technologies in your marketing day-to-day? Well, AI can already do the things like designing custom logos, optimizing your paid ad campaigns, helping you write great content, and a lot of other interesting things. But most people aren't familiar with these technologies, and they still spend a lot of manual time doing the stuff that can already be automated. To be honest, up until now, I was also doing a lot of them manually, but over the last six months to a year, I've learned about a lot of these tools.
So let's dive right in. There's CopyAI. This AI tool generates tons of copy from just one basic summary text that you input. From product descriptions to paid ad copy, to even blog titles, it can help in several different areas of marketing activities.
Then there's Beautiful.ai. If you hate coming up with presentations because, hey, the design suck, it's messy, takes a lot of time, this tool is perfect for you. It uses AI to automatically enhance your designs accordingly so that your content looks beautiful. And it adjusts it based on your content. So you don't even need to worry about messing with the layouts.
Then you got Profile Picture Maker. This tool uses AI to remove the background from your photos and make amazing profile photos for you to use on social media or even company about pages, like those headshots that people show on the executive pages. The end result is pretty amazing, and best all, it's absolutely free.
Then you got Brandmark.io. Now, you don't even need a graphic designer to come up with a logo for your business. This tool uses AI to create logos automatically for you based on a set of preferences. It creates dozens and dozens of different variations that you can pick from and choose from. And if you like one of them and want to use on your business, you can purchase that logo right then and there.
Then you got Oribi.io. This tool is basically analytics on steroids. It will automatically track all the events on your website and come up with the suggestions of things that you could be doing to improve your performance. It'll look at things like your conversion funnels, traffic sources, identify the strengths, opportunities for improvements. It pretty much does a lot of stuff automatically for you.
Next, Synthesia.io. If you're camera shy and you don't like to talk in public, you may like this one. It generates video that looks almost identical to a human speaking, and it'll almost freak you out because it is pretty realistic.
Then you got Unscreen.com. This tool also allows you to remove the background from any video that you shoot. You know, people are just like, "Oh yeah, I can remove background images." I'm talking about video images. You don't even need a green screen or anything like that. It'll remove even the more complex backgrounds.
► If you need help growing your business check out my ad agency Neil Patel Digital https://npdigital.com/
►Subscribe: https://goo.gl/ScRTwc to learn more secret SEO tips.
►Find me on Facebook: https://www.facebook.com/neilkpatel/
►On Instagram: https://instagram.com/neilpatel/
#SEO #NeilPatel #DigitalMarketing
Tags:ai and marketingai content writing toolsai copywriting toolsai in marketing examplesai marketingai marketing appai marketing automationai marketing legitai marketing platformai marketing robotai marketing softwareai marketing strategyai marketing technologyAi marketing toolsai seo toolsai toolsai writing toolsartificial intelligence marketing toolsartificial intelligence toolsBe Affiliate Kingcontent marketingdigital marketingdigital marketing agencydigital marketing jobsDigital Pratikemail marketingfacebook adsflexifunnelsgoogle my businessinstagram best hashtags for likes and followers 2022instagram tricks 2022is ai marketing legitlanding pageNeil Patelneil patel digital marketingRussell Brunsontools for ai
50 thoughts on "7 A.I. Marketing Tools That Will BLOW YOUR MIND"
Neil Patel March 16, 2022 at 7:05 pm
Are you using any AI marketing tools that weren't listed in this video? Share in the comments below.
George Washington March 26, 2022 at 4:49 pm
I went from Jasper to Copy.
CopyAI is the best tool ever!
Mohamed Abouras March 26, 2022 at 4:55 pm
Oribi's pricing is kinda exaggerated
Tom Derbyshire March 26, 2022 at 5:23 pm
Someone needs to make a business only using AI
WBT Agency March 26, 2022 at 5:24 pm
Thank you Neil for sharing these 7 A.I. marketing tools. It definitely blew our minds.
Digitalbird_ hinu March 26, 2022 at 5:24 pm
Last tool are really useful for us ❤
Sushil Khanagwal March 26, 2022 at 5:28 pm
Amazing 🙂 Is there sophisticated AI for text to speech .. even if it is paid?
K Bishop March 26, 2022 at 5:48 pm
Jasper and bramework
Mohammad Imtiaz Qureshi March 26, 2022 at 5:52 pm
Excellent piece of information!
Prince Asif March 26, 2022 at 5:58 pm
I want guidelines on digital marketing one on one please Someone help me regarding earnings through that or refer me about some free course I'll be thankful
Tessa Rhodes March 26, 2022 at 6:54 pm
Wow! This is just what I needed. It came at the perfect time.
Raam Srinivas March 26, 2022 at 7:02 pm
Write Sonic
Rytr
Yeasin Arafat March 26, 2022 at 7:21 pm
Please Share some free AI tools
Jason Hall March 26, 2022 at 8:36 pm
Thanks for sharing man I knew
of 3 of these software
Nathan Donaldson March 26, 2022 at 8:58 pm
Neal, how do you find your competitors ads when you don't know who your competitor actually is? I know that sounds weird but, I'm tired of buying leads from lead vendors and I'd like to make my own ads to generate my own leads (Google Adwords). The lead vendors don't reveal anything about the domains their ads are pointing to, so I'm having a hard time analyzing ads. So how do we find ads when we know (roughly) what the creative is saying but don't know the domains that those ads are attached to?
Marketing Harry March 26, 2022 at 9:09 pm
Awesome tools, Neil. I find them interesting and very helpful. Let's take advantage on these AI tools 👍
Aboubacar Traore March 26, 2022 at 9:28 pm
This videos is absolutely one of the best or even may be the best video that one can watch and grow your sales.
aldean fenton March 26, 2022 at 10:12 pm
This is very helpful, Neil. Thank you so much for sharing!!
Mike Boldis March 26, 2022 at 11:19 pm
What is the best SEO optimization AI tool in your opinion?
Shiv Shankar Prasad March 27, 2022 at 12:18 am
Woww
Manju Mani March 27, 2022 at 1:56 am
APPTOKPH March 27, 2022 at 3:31 am
Brilliant tools ✨
thank you so much for sharing this info.. I already save this video for my future reference 😊.
Lisa, Marco, Cassandra Di Tomasso March 27, 2022 at 4:29 am
AI starts with people like Larry Page – tools that will blow my mind. Go ahead, blow it.
Zac Alawi March 27, 2022 at 6:28 am
Was that N Patel or an AI? The last tool mentioned..m
Anish Daga March 27, 2022 at 6:44 pm
Last 2 tools aren't free. Their brand logo watermark is there on the videos 🙂
Ittehad Abdullah March 27, 2022 at 7:28 pm
please don't move your hands so repeatedly, it hampers keeping concentration
Anatolii Ulitovskyi March 28, 2022 at 7:31 am
AI marketers believe that their tools will increase a company's promotional visibility, efficiency and most of all, bottom line. The future of marketing is already here with A.I. coming in to primarily help the marketers automate their task by assessing the target from data collected from email marketing (CPC, keyword targeting etc.), social media follower activities, website behavioral data and onboarding process and devising engaging content which not only provides adequate ROI but also connects with the right audience at the right time with little/no effort involved. Thanks for your video,
Tiliki Stephen March 28, 2022 at 7:40 am
I am impressed that you embrace these tools. I've seen a couple of content writers getting edgy because of them.
Lucie Marcolongo March 28, 2022 at 8:37 am
Mark Copy AI is also an amazing tool to write and optimise your copies 🙌
vesogry March 28, 2022 at 10:02 am
Congrats for 1 million subs. In this field, it's a great achievement.
Joana Partosa March 28, 2022 at 12:55 pm
Wow this is great Neil! Excited to use them! Thank you!
Web Mention March 28, 2022 at 3:51 pm
Can Ai replace humans in the field of content writing like long form blog posts and also match human touch in writing.
Lew Salonowy March 29, 2022 at 1:22 am
Wow, Neil. I am your new fan! Keep doing I appreciate!
Shantanu Bhattacharjee March 29, 2022 at 7:28 am
How these DM skills help 50-yr old man to earn in india.
Muhammad Usman March 29, 2022 at 8:48 am
Neil, AI Generated content( Generating Articles, Blogs With AI) + Human Effort with this (Like Putting emotions, Content optimization etc) has a great future? On Google?
World ⊙﹏⊙ LIFE March 29, 2022 at 12:44 pm
Good dude keep continue…….
Barb C March 29, 2022 at 8:21 pm
Wow! Thanks, Neil. I will try all of them. Why the drum and upside-down effects in the videos? All those effects distracted me from what you were saying.
Mohd Jibly March 30, 2022 at 1:23 pm
These tools are awesome…thanks Neil 🙂
Priya Tarachand April 2, 2022 at 6:34 am
Nice, this is very helpful.
Artificial Intelligence and Blockchain April 3, 2022 at 9:03 pm
Awesome content, thanks! There are tons of new ai tools out there to use for different use cases! Always good to share them so we all can improve!
OLUWATOBILOBA MICHAEL ODELEYE April 9, 2022 at 5:31 am
I love Copy AI ❤
Manoj Agadi April 15, 2022 at 11:05 am
Amazing Information Sir.
Patrick Giles May 15, 2022 at 11:01 pm
Neil, love your content, but that transition in the video (the whomp sound) is really irritating
Butelca John May 28, 2022 at 5:37 am
Ok. I understand you have to give your opinion on some digital products, but saying "you don't even need a graphic designer to …" this is really offensive to an entire profession and to those people who worked their butts to pay their studies to learn that profession. Probably, if tomorrow there will be an ai product that, based on some symptoms we describe, will give us a diagnostic, you will also say " you do not even need a doctor…". So, curb your enthusyasm a little and maybe, in your future "presentations" you will avoid making references to people's way of making a living. Someday, an eighth version of an ai tool will blow your mind, too and, of course ours, will be able to replace those who give us presentations on ai, on youtube.
JuJu July 14, 2022 at 9:54 pm
Oh Neil your contents are always awesome. I think u should review jasper and steve ai
Cey Da August 10, 2022 at 10:46 pm
I appreciate you recommending these valuable tools; I will definitely find them handy. WASK allows me to control all aspect of my business through a single channel, including target audience identification, ad creation, and competitor analysis.
Rajkishor Sahu August 31, 2022 at 11:07 am
The art of Sales funnel, copywriting and Facebook ads/ Google ads can be done by AI from start to finish ?
Vannavy Vicheanak October 2, 2022 at 9:10 am
talk sh*t
Password consultant October 3, 2022 at 3:49 pm
Awesome tips.. thanks
Eric October 5, 2022 at 6:06 pm
I love your video, but those sounds you're putting in the video are killing my speakers


text:
Razib Hossain
Associate Creative Director / Brand Design
With more than a decade of advertising and design experience at some of the world's most renowned ad agencies, Creative Shakhawat Hossain, who is also known as Razib, is the definition of a passionate artist.
Extremely driven with a strong background in strategy and brand building, this man is never satisfied with his work; no matter the awards and accolades that are attached to it, he knows what he creates will always have room for improvement. At Noble, we think the same.
We know that if we want to be a best-in-class agency with passionate, world-class clients, we have to go all in and show commitment to everything we do. Razib is nothing short of committed to the creative that drives business and impact for his clients, and if you can't tell by his photo, restraining his wild creativity is a big job.
Originally from Dhaka, Bangladesh, Razib has an M.F.A. and B.F.A. from the University of Dhaka where he studied drawing and painting. His career began with an internship at TBWA Bangladesh, where he would become the country's youngest art director. From here, he moved on to Ogilvy & Mather and led the charge for his art team while working for internationally recognized clients such as The Hard Rock, Caesars Entertainment, Visa, Toshiba, KFC, Mentos, Pizza Hut and many more.
Outside of work, you'll find Razib focusing on three things: art, art, and ART (maybe a little sleep in between, as he loves to dream). He has been featured in numerous art exhibitions around the world, including the Asian Art Biennale in Bangladesh, Group Show at the KRINZINGER PROJEKTE in Vienna, Austria, and the Open-15 International Sculpture & Flag Show in Venice, Italy, where his work was alongside legendary artist, Yoko Ono. He has also shown multiple short films of his own creation selected for the Las Vegas Film Festival, the In-Short Film Festival in Nigeria and the Lift-off Global Network in London.
Needless to say, the creative team could not be more thrilled to hit the whiteboards with him.
"Never forget that only dead fish swim with the stream."
Malcolm Muggeridge
Gabbi Hall
Davis Bauman


Jan. 25 premiere of new sonic and video art installation and dance performance at Qualcomm Institute, Cetacea, contemplates oceanic timescapes from the perspective of whales and dolphins.
Cetacea (pronounced seh-tay-shuh) is a sonic and video installation dance performance that contemplates oceanic timescapes. This new work elaborates on choreographer and dancer Aurora Lagattuta's prior solo, Inside the Whale. Cetacea further develops movement as well as sound and video research on the temporal experience of cetaceans (primarily whales, dolphins and porpoises).
This multimedia performance communicates with and through virtual as well as material presences in a performance ecology that integrates fragments of reality, virtuality and imagination. Cetacea aims to transport the audience into reflexive states around how audience members experience time and underwater landscapes.
The performance is a collaboration among choreographer Lagattuta, visual artist and projectionist Maya VanderSchuit, and composer Kevin Zhang.
Lagattuta is a second-year MFA candidate in Contemporary Dance Making and Performance at UC San Diego, where she received the prestigious San Diego Fellowship. Lagattuta toured her previous work, Inside the Whale, across Europe. Her collaborators on Cetacea are also UC San Diego graduate students: Maya VanderSchuit is an MFA Visual Arts candidate in editing and video design at UC San Diego in the Visual Arts department; and Kevin Zhang received his undergraduate degree in music at the New England Conservatory of Music, an MFA in Music from UC Irvine, and he is currently pursuing his Ph.D. in Music at UC San Diego with an emphasis on composition.
"Access to the Qualcomm Institute's advanced audio-visual facilities provides an ideal environment to stage this new work," explained Lagatutta. She is no stranger to the Qualcomm Institute IDEAS series: Lagattuta performed in Yolande Snaith's Measuring the Dream during the IDEAS 2016-2017 season.
IDEAS performances are open to the public, and admission is free.


Getting there... Have started to work on blue and purples to create more contrasts. Also I've tried to accentuate some of the colours to get them more vibrant - meaning I've added more paint and in different hues.
Well, this is really not day 7, as I said when I started this. I've had days in between where I've done little silly things - as I call them - but all part of what it takes to create a finished work.
I've now gotten rid of the copper and have added black in stead. Is also playing around with some small paint skins, to add different kind of textures and help to make the paintings flow better.
Added a bit of copper - but don't really like it, so think I'll change that to... maybe black... I've used some more orange to break through some of the other shapes - and mixed orange into the pink.
Bits of black has been added - and some tape has been removed - and more shapes have been 'refined.
Added more of the background colour and started adding pink as well.
Welcome to my new blog. Whether I'm going to keep up adding to this blog I'm not sure - as I'm also trying to keep my Facebook page updated. So it's all down to time and whether I have anything to say I guess.
For me being an artist means that you show sides of yourself that you wouldn't - perhaps - always show off like that. You're putting your heart out there for everybody to step on - with people telling you that; 'my daughter could do this' or 'a monkey could have done that'. And all you can think is - 'well, why don't they then....'.


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Advancements in heart surgery continue to yield excellent outcomes for a wide array of cardiovascular conditions, from coronary artery disease and valve disorders to heart failure and atrial fibrillation. At NorthShore, our highly trained cardiac surgeons use the latest minimally invasive techniques and innovative surgical methods found only in the nation's premier medical centers. Striving to enhance quality of life and extend longevity for our patients, we provide leading-edge cardiac surgery care with a personal touch that ensures an exceptional patient experience.
Integrated team care is essential for optimal results before and after cardiac surgery. The multidisciplinary approach of the NorthShore Cardiovascular Institute (CVI) involves the close coordination of cardiac services from the moment you enter our doors. Our CVI team of cardiologists, cardiac surgeons and nurses work together as one: the same team all the time. This consistency ensures continuity of care and access to specialists always on top of your unique medical and surgical treatment needs. Clinical navigators serve as one constant point of contact and help to guide patients throughout the surgical journey: from pre-op workups to post-surgery follow up. The CVI keeps referring physicians up-to-date on your care and follow-up plan for a seamless transition after you leave the hospital.
Long the standard of care for coronary artery disease, coronary artery bypass grafting (CABG) surgery remains one of the best methods for unblocking clogged arteries narrowed by plaque buildup (atherosclerosis). An open heart procedure, CABG surgery involves taking a blood vessel from the chest wall or leg and using it restore blood flow to the affected portion of the heart muscle. NorthShore's cardiac surgeons continually achieve superior outcomes with CABG procedures and have one of the lowest complication rates in the region.
Malfunctioning heart valves can result from narrowing (stenosis) of the valve or leaking (regurgitation) of a valve. In either case, the heart must work harder to pump blood to the body. Open-heart surgery continues to be a standard surgical option to repair and/or replace valves.
For valves that cannot be repaired, an artificial valve may be required to replace the faulty valve. NorthShore's cardiac surgeons employ the use of mechanical or biological replacement valves. Mechanical valves are made from man-made materials. Most biological valves originate from animal tissue, and some valves come from human donor hearts.
Some patients may not qualify for open-heart surgery due to poor health. Or they are at high risk for complications. Innovating novel surgical options, NorthShore's cardiac surgeons and interventional cardiologists are breaking ground on the use of minimally-invasive catheter-based techniques to either repair or replace heart valves, or correct other structural heart disease conditions. In fact, NorthShore was the first medical center in the country to pioneer a minimally invasive technique for mitral valve repair.
NorthShore offers a number of clinical trials assessing the efficacy and outcomes of state-of-the-art heart valve procedures.
Severe heart failure can lead to a heart so weak it can no longer effectively pump blood throughout the body. Some patients may require a ventricular assist device (VAD) to help support blood flow while awaiting a heart transplant or as a long-term solution to relieve debilitating symptoms of congestive heart failure.
Implantation of these mechanical devices occurs most commonly in the left ventricle of the heart. Known as left ventricular assist devices (LVADs), this often lifesaving procedure requires open-heart surgery. NorthShore's cardiac surgeons have vast experience with LVAD and other mechanical assist procedures, using the latest generation of mechanical heart pumps and achieving outstanding outcomes.
Treatment for atrial fibrillation can include medications, catheter ablations and surgery. NorthShore's cardiac surgeons routinely perform the "Maze Procedure" to treat the condition in patients with atrial fibrillation who are undergoing valve or coronary surgery. Certain patients with atrial fibrillation may be candidates for the nContact Convergence procedure, which combines elements of both catheter-based and surgical techniques in a minimally invasive fashion.
For more information about cardiac surgery, please call 847.864.3278.
Terry Ikoma shares how her skillful cardiology team collaborated on her potentially fatal heart issue.
Thomas Winklebleck feels his best in 10 years following emergency cardiac surgery that included an innovative life support system postsurgery.


Jade is an English Actress born in Bournemouth, Dorset.She is most known as Patricia Williamson in the Belgian/American/British Teen Drama Mystery television series of Nickelodeon: House of Anubis.She has a twin sister, Nikita Ramsay who is also acting.Her first professional acting job was X-Men 2 as a X-Kid.She has appeared in a lot of movies and television shows in which she mostly acts along side her twin, Nikita.
Jade is an English Actress born in Bournemouth, Dorset.She is most known as Patricia Williamson in the Belgian/American/British Teen Drama Mystery television series of Nickelodeon: House of Anubis.She has a twin sister, Nikita Ramsay who is also acting.Her first professional acting job was X-Men 2 as a X-Kid.She has appeared in a lot of movies and television shows in which she mostly acts along side her twin, Nikita. - IMDb Mini Biography By: stef castaneda Twin sister of Nikita Ramsey. She has appeared in a lot of movies and television shows with her sister such as The Myth of the American Sleepover, X-Men 2. She auditioned for the role of Patricia Williamson in House of Anubis, with her sister, and eventually got the part. She auditioned for the part of Nina Martin in House of Anubis but lost to Nathalia Ramos. She was part of Chick Comedy on YouTube, along with her sister, in a short film called "Twinny Something".


This year, Elmo, Cookie Monster, Abby and more of your favorite characters from Sesame Street are heading to the main stage at The Pavilion for what is sure to be the party of the year.
Join in the excitement, laughter and music of Sesame Street Live! C is for Celebration at three performances – Saturday at 11 a.m. and 3 p.m. and Sunday at 3 p.m.
You can purchase tickets at The Pavilion Box Office Monday through Friday from 10 a.m. to 5 p.m., online here, by calling 800-745-3000 or the day of the event.
Admission is $10 per person and includes all performances and activities. Children age 2 and under are free of charge. All activities and performances are included in the price of admission.


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Home › News › Cassandra Cole Ready to Build on Rookie Season in Stafford's SK Lights
Cassandra Cole Ready to Build on Rookie Season in Stafford's SK Lights
Posted on February 14, 2018 by Scott Running	Posted in News
(Stafford Springs, CT)—After racing Legend Cars from 2014-2016, Westbrook native Cassandra Cole made her debut in the SK Light division at Stafford Motor Speedway last July. Cole made 9 starts over the final 11 races of the 2017 season in her #09 MAWC Accounting machine, posting a best finish of 10th on August 4th. Cole used her time to get acclimated to a new style of car and racing and the team managed to get her #09 car faster week by week and by the end of the season, Cole found herself in the top-2 on the speed charts during practice sessions.
"I feel confident coming into this season," said Cole. "I gained a lot of knowledge last year and learned a lot every event. We gained some speed each week and our main goal was to have fun, not wreck the car, and try to be faster than we were the previous week. We're going to keep on trying to learn and we're going to run for points so we need to be consistent and not wreck the car, but that's what everyone wants to do. It seems like last year we were always in the wrong place at the wrong time. I feel like we'll have a better shot at getting into the top-10 this year because last year I wasn't that confident with the car. We'd be happy with top-10 finishes this season but we'd really love it if we could get into the top-5 or even in the top-3 on the podium. A podium finish would be awesome because then I'd be able to give a shout out to all my sponsors who have helped me get to this point."
In making the move from Legend Cars to the open wheel world of SK Light racing, Cole had to learn a new car, how to race against new competition and also contend with racing around the half-mile Stafford layout for the very first time.
"It took me a while to get confident with passing cars with the difference in size between a Legend Car and the SK Light," said Cole. "Learning how to keep your forward momentum up in the SK Light car was a big thing for me. With the Legend Car you can just floor it and the car will go but with the SK Light you have to keep the speed up and be smooth through the corners. It also took me a couple of weeks to get used to the track. I definitely didn't have it down the first couple weeks but towards the end of the season I felt more confident with the car and we ended up having the fastest time in a couple of practice rounds in the last two Friday night races."
Cole and the #09 team hooked up with Keith Rocco for their rookie campaign with Rocco helping to supply the team with car setups. Cole says that working with the 3-time Stafford SK Modified® track champion was a blessing and helped shorten her learning curve with how to get an optimal car setup for Stafford.
"It's awesome having Keith to work with," said Cole. "He definitely knows what he's doing and he has an answer for everything. When something is wrong with the car, you name it, and he has it figured out. Thanks to Keith, our setup was always on point when we showed up to the track so there wasn't much we had to change on the car. This winter we've been putting a lot of upgrades on the car. It's a lot of little things that will all add up in the end."
With her 9-race rookie season under her belt and Keith Rocco once again helping out with the car setups, Cole is excited to get her 2018 season started.
"I'm very excited to get started this season," said Cole. "I've been going to On Track Karting every week to get my racing fix. That's how I've been spending my off-season and I'm counting down the days to the Spring Sizzler. I have to thank MAWC Accounting, The Garage Door Guys, Tri-State Glass Co., Downey Septic and Excavation, my Dad, my brother, and my Mom for all their support and Keith Rocco Racing for giving me a fast setup every week. The competition is going to be super stiff this year. Bryan Narducci is moving up and he's fast, Marcello Rufrano is fast, there's a lot of fast cars and I think Stafford has the best of the best SK Light drivers. If you're good at Stafford, I think you can be good at any track. I have lot of confidence knowing our car is fast and it's all going to come down to me being able to get through traffic and being more confident passing cars."
The 2018 SK Light season will begin at the 47th Annual NAPA Auto Parts Spring Sizzler® on April 27-29. Tickets for the "Greatest Race in the History of Spring" are on sale now at the Speedway Box Office. Tickets are priced at $40.00 for adult general admission tickets, $5.00 for children ages 6-14, and children ages 5 and under are admitted free of charge when accompanied by an adult. Reserved seating is priced at $42.00 for all ages. As always, Stafford Motor Speedway offers free parking with overnight parking available. All tickets are good for both Saturday and Sunday admission. All ticket prices include 10% CT Admission Tax. Discount Spring Sizzler® tickets will be available beginning in March at participating NAPA Auto Parts stores.
For more information contact the Stafford Motor Speedway track office at 860-684-2783 or visit us on the web at www.staffordspeedway.com.
‹ Bryan Narducci to Challenge for SK Light R.A.D. Auto Machine Rookie of the Year Honors at Stafford Speedway
New Sponsorship Has Matt Clement Primed for Breakout Season at Stafford ›


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Direct detection of alpha synuclein oligomers in vivo
Hemi Dimant, Suneil K. Kalia, Lorraine V. Kalia, Liya N. Zhu, Laura Kibuuka, Darius Ebrahimi-Fakhari, Nikolaus R. McFarland, Zhanyun Fan, Bradley T. Hyman, Pamela J. McLean
Background: Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. Results: Viral coinjection resulted in widespread VenusYFP signal within the nigrostriatal pathway, including cell bodies in the substantia nigra and synaptic accumulation in striatal terminals, suggestive of in vivo alpha-synuclein oligomers formation. Transduced rats showed alpha-synuclein induced dopaminergic neuron loss in the substantia nigra, the appearance of dystrophic neurites, and gliosis in the striatum. Moreover, we have applied in vivo imaging techniques in the living mouse to directly image alpha-synuclein oligomers in the cortex. Conclusion: We have developed a unique animal model that provides a tool for the Parkinson's disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers.
Acta Neuropathologica Communications
https://doi.org/10.1186/2051-5960-1-6
Alpha synuclein
Live imaging
Oligomers
10.1186/2051-5960-1-6
Fingerprint Dive into the research topics of 'Direct detection of alpha synuclein oligomers in vivo'. Together they form a unique fingerprint.
alpha-Synuclein Medicine & Life Sciences
Substantia Nigra Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
rat Snca protein Medicine & Life Sciences
Pars Compacta Medicine & Life Sciences
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Medicine & Life Sciences
Dimant, H., Kalia, S. K., Kalia, L. V., Zhu, L. N., Kibuuka, L., Ebrahimi-Fakhari, D., McFarland, N. R., Fan, Z., Hyman, B. T., & McLean, P. J. (2014). Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications, 2(1), [6]. https://doi.org/10.1186/2051-5960-1-6
Direct detection of alpha synuclein oligomers in vivo. / Dimant, Hemi; Kalia, Suneil K.; Kalia, Lorraine V.; Zhu, Liya N.; Kibuuka, Laura; Ebrahimi-Fakhari, Darius; McFarland, Nikolaus R.; Fan, Zhanyun; Hyman, Bradley T.; McLean, Pamela J.
In: Acta Neuropathologica Communications, Vol. 2, No. 1, 6, 27.01.2014.
Dimant, H, Kalia, SK, Kalia, LV, Zhu, LN, Kibuuka, L, Ebrahimi-Fakhari, D, McFarland, NR, Fan, Z, Hyman, BT & McLean, PJ 2014, 'Direct detection of alpha synuclein oligomers in vivo', Acta Neuropathologica Communications, vol. 2, no. 1, 6. https://doi.org/10.1186/2051-5960-1-6
Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D et al. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications. 2014 Jan 27;2(1). 6. https://doi.org/10.1186/2051-5960-1-6
Dimant, Hemi ; Kalia, Suneil K. ; Kalia, Lorraine V. ; Zhu, Liya N. ; Kibuuka, Laura ; Ebrahimi-Fakhari, Darius ; McFarland, Nikolaus R. ; Fan, Zhanyun ; Hyman, Bradley T. ; McLean, Pamela J. / Direct detection of alpha synuclein oligomers in vivo. In: Acta Neuropathologica Communications. 2014 ; Vol. 2, No. 1.
@article{8590079d6d0e4aeba73264ef09101c40,
title = "Direct detection of alpha synuclein oligomers in vivo",
abstract = "Background: Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. Results: Viral coinjection resulted in widespread VenusYFP signal within the nigrostriatal pathway, including cell bodies in the substantia nigra and synaptic accumulation in striatal terminals, suggestive of in vivo alpha-synuclein oligomers formation. Transduced rats showed alpha-synuclein induced dopaminergic neuron loss in the substantia nigra, the appearance of dystrophic neurites, and gliosis in the striatum. Moreover, we have applied in vivo imaging techniques in the living mouse to directly image alpha-synuclein oligomers in the cortex. Conclusion: We have developed a unique animal model that provides a tool for the Parkinson's disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers.",
keywords = "Alpha synuclein, Animal model, Live imaging, Oligomers, Parkinson's disease",
author = "Hemi Dimant and Kalia, {Suneil K.} and Kalia, {Lorraine V.} and Zhu, {Liya N.} and Laura Kibuuka and Darius Ebrahimi-Fakhari and McFarland, {Nikolaus R.} and Zhanyun Fan and Hyman, {Bradley T.} and McLean, {Pamela J.}",
note = "Funding Information: The authors thank Michal Arbel and Eloise Hudry for their help with craniotomy surgeries and two-photon microscopy and Steve Rodriguez for his help with fluorescent microscopy. P.J.M is supported by NIH NS063963. H. D is supported by Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32). D.E.-F. received support from the German National Academic Foundation (Studienstiftung des deutschen Volkes e.V.) and the Parkinson's Disease Foundation. N.R.M. is supported by K08 NS067024. L.V.K. is supported by a Canadian Institutes of Health Research Clinician-Scientist Award. This paper is dedicated to Laura Kibuuka.",
doi = "10.1186/2051-5960-1-6",
journal = "Acta neuropathologica communications",
T1 - Direct detection of alpha synuclein oligomers in vivo
AU - Dimant, Hemi
AU - Kalia, Suneil K.
AU - Kalia, Lorraine V.
AU - Zhu, Liya N.
AU - Kibuuka, Laura
AU - Ebrahimi-Fakhari, Darius
AU - McFarland, Nikolaus R.
AU - Fan, Zhanyun
AU - Hyman, Bradley T.
AU - McLean, Pamela J.
N1 - Funding Information: The authors thank Michal Arbel and Eloise Hudry for their help with craniotomy surgeries and two-photon microscopy and Steve Rodriguez for his help with fluorescent microscopy. P.J.M is supported by NIH NS063963. H. D is supported by Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32). D.E.-F. received support from the German National Academic Foundation (Studienstiftung des deutschen Volkes e.V.) and the Parkinson's Disease Foundation. N.R.M. is supported by K08 NS067024. L.V.K. is supported by a Canadian Institutes of Health Research Clinician-Scientist Award. This paper is dedicated to Laura Kibuuka.
N2 - Background: Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. Results: Viral coinjection resulted in widespread VenusYFP signal within the nigrostriatal pathway, including cell bodies in the substantia nigra and synaptic accumulation in striatal terminals, suggestive of in vivo alpha-synuclein oligomers formation. Transduced rats showed alpha-synuclein induced dopaminergic neuron loss in the substantia nigra, the appearance of dystrophic neurites, and gliosis in the striatum. Moreover, we have applied in vivo imaging techniques in the living mouse to directly image alpha-synuclein oligomers in the cortex. Conclusion: We have developed a unique animal model that provides a tool for the Parkinson's disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers.
AB - Background: Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. Results: Viral coinjection resulted in widespread VenusYFP signal within the nigrostriatal pathway, including cell bodies in the substantia nigra and synaptic accumulation in striatal terminals, suggestive of in vivo alpha-synuclein oligomers formation. Transduced rats showed alpha-synuclein induced dopaminergic neuron loss in the substantia nigra, the appearance of dystrophic neurites, and gliosis in the striatum. Moreover, we have applied in vivo imaging techniques in the living mouse to directly image alpha-synuclein oligomers in the cortex. Conclusion: We have developed a unique animal model that provides a tool for the Parkinson's disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers.
KW - Alpha synuclein
KW - Animal model
KW - Live imaging
KW - Oligomers
KW - Parkinson's disease
U2 - 10.1186/2051-5960-1-6
DO - 10.1186/2051-5960-1-6
JO - Acta neuropathologica communications
JF - Acta neuropathologica communications


October 5 has written a new chapter in favour of daughters in Madhya Pradesh. On the day, Beti Bachao Abhiyan was launched in all the districts of the state and on the other hand a glorious welcome was accorded to more than 1,000 girls reaching CM House here. All sections of society, voluntary organisations, heads of religions, social workers and educational institutions took part enthusiastically in this massive campaign launched on the initiative of Chief Minister Shri Shivraj Singh Chouhan. Incharge ministers launched this campaign in districts while Beti Bachao Abhiyan was launched in Vidhan Sabha constituencies by people's representatives.
At Bhopal, CM House reverberated with hustle and bustle of girls. Various Panchayats have been organised at the CM House where people of higher age groups have taken part. But today, neither there was any Panchayat nor the age of visitors was more. They had reached there just on the invitation of popular Chief Minister Shri Shivraj Singh Chouhan. The girls were in a hurry to reach the CM House and on the other Chief Minister Shri Chouhan also reached the venue 15 minutes before the scheduled time. He interacted with girls in his simple style and showered flower petals on them. The girls were also gripped by emotions by finding the Chief Minister amidst them.
Today, there were no books in the hands of these schoolgirls, but a letter of resolve for saving daughters which they were going to read out with the Chief Minister. Their Mama (maternal uncle) Shri Chouhan also took care of the girls. He instructed that the girls take the oath by sitting on chairs.
Senior politician and former Chief Minister Shri Sundarlal Patwa, Shri Kailash Joshi and Shri Gaurishankar Kaushal also reached CM House to give their blessings. After the launch of the campaign, the girls ate kheer-puri by sitting in pangat. Chief Minister Shri Chouhan and his wife Smt. Sadhna Singh Chouhan served food to the girls and presented money to them as shagun.
When the Daughter of MP will get Rs 2 lakhs Award?
Public relation council of india, Bhopal chapter & leading newsmagazine Metromirror.com had taken the initiative to honour the talented 'daughters of Bhopal' to mark the birth of the talented daughter of India Kalpana Chawla on July 1,2009. On this day talented daughters & Women of Bhopal were presented the PRCI-Metromirror.com 'Daughters of Bhopal' awards by the chief guest Shri Laxmikant Sharma, Public relations minister, Govt. of MP. Taking clue from the daughters of Bhopal awards Mr. Sharma on this occasion had also announced the Rs. 2 lakhs national award for the talented daughter of madhyapradesh, for which he announced that a committee would be constituted soon to decide about the awards in the current financial year. After the lapse of almost 2 years no action has been taken to finalise the process and announce the award. Talented 'Ladli' of Madhyapradesh is eagerly awaiting to receive the prestigious award.


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Савени има више значења:

 Савени (Ботошани), насеље у округу Ботошани у Румунији
 Савени (Јаломица), насеље у округу Јаломица у Румунији
 Савени (Јаши), насеље у округу Јаши у Румунији
 Општина Савени (Ботошани), општина у округу Ботошани у Румунији
 Општина Савени (Јаломица), општина у округу Јаломица у Румунији

redpajama_set_name: RedPajamaWikipedia


Faculty, staff, students, and non-campus workers should all react to emergencies in the same manner. VCSU created an acronym that will help the campus react efficiently during an emergency.
R-RECEIVE: Receive, retrieve, relay and react to the emergency message or alarm.
A-ALERT: Alert others and assist those in need. Use fire alarm ONLY during a fire.
C-CONFINE: Confine the situation by closing all doors and windows.
E-EVACUATE: Evacuate everyone to a designated location if instructed. Area emergency services will arrive shortly.


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In an effort to build even more hype, remote control car builders Sphero have introduced a hyper-realistic Lightning McQueen that can be controlled via your smartphone.


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Jimmy Jam, Terry Lewis & Babyface Serve As Music Producers For BET's 'The New Edition Story'
We almost forgot we were sitting here patiently waiting for BET's miniseries, The New Edition Story, which debuts in 2017. The network has been dropping trailers and rehearsal footage from the project, but this week they revealed the music masterminds behind the production. James "Jimmy Jam" Harris, Terry Lewis and Kenny "Babyface" Edmonds will serve as music producers for the much-anticipated biopic about New Edition. Each producer has a long history with the group, so it comes as no surprise that they are happily involved. Jimmy Jam and Terry Lewis produced New Edition's fifth studio album, N.E. Heartbreak, back in 1988, which included iconic hits like "If It Isn't Love," "You're Not My Kind of Girl" and "Can You Stand the Rain." Babyface, along with partner L.A. Reid lead the charge on hits like N.E. member Bobby Brown's "Don't Be Cruel" and "Every Little Step."
Despite helping produce half of the group's hits, Babyface will handle the first half of the series, and Jam and Terry will take on the rest. "I learned a lot about Bobby and the band dynamic during the making of "Don't Be Cruel." But I also lived and breathed '80s R&B because I was performing with my band (The Deele) and producing with L.A. Reid, so I make sure the feeling was captured," said Babyface in a press release. "Terry and I came in at a pivotal time when they were having internal issues and growing pains. Fans will get the true behind-the-scenes story of this key phase in their personal lives and careers," said Harris.
Executive Producer Jesse Collins and award-winning director Chris Robinson enlisted the help of the iconic producers for the biopic, which features Bryshere Gray (Michael Bivins), Elijah Kelley (Ricky Bell), Algee Smith (Ralph Tresvant), Keith Powers (Ronnie Devoe), R&B crooner Luke James (Johnny Gill) and Woody McClain (Bobby Brown). It's safe to say we still can't wait to catch The New Edition Story, which will premiere on January 24, 2017 at 9 p.m. ET/PT on BET. Watch behind the scenes footage on BET's website, and catch an exclusive interview with Jimmy Jam and Terry Lewis discussing New Edition's classic sound right here.
TAGS: Algee Smith, bobby brown, bryshere gray, chris robinson, Elijah Kelley, James "Jimmy Jam" Harris, Jesse Collins, johnny gill, Keith Powers, Kenny "Babyface" Edmonds, l.a. reid, luke james, michael bivins, new edition, ralph tresvant, ricky bell, ronnie devoe, terry lewis, The Deele
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HomeFeaturedTrash Bash 2021 beautifies St. Charles Parish
Trash Bash 2021 beautifies St. Charles Parish
March 12, 2021 Monique Roth Featured, Lifestyles
Shell joined forces with the Norco Civic Association to clean up the parish.
Litter crews made up of more than 450 participants deployed across St. Charles Parish Saturday, as the parish hosted its 13th annual Trash Bash event.
Each year the Trash Bash is planned to promote the removal of litter from parish streets.
"It is important to keep our parish clean and free of litter and debris for both our quality of life and to protect the environment," St. Chares Parish President Matthew Jewell said. "Not only does litter make a bad impression for residents, but it does for businesses as well. We hope that residents … keep St. Charles Parish a clean place to live."
Local industry partners, including Shell and Valero, pitched in at the beautification effort.
Approximately 75 Valero volunteers, including Valero Energy's Vice President and General Manager Jerry Stumbo, and more than 35 Shell volunteers, including Shell General Manager Tammy Little, joined forces with the We Are New Sarpy civic group and the Norco Civic Association to clean up the parish.
Small family groups who live in the same household were encouraged to participate as one group to keep volunteers safe and socially distanced while participating in the clean-up effort. All volunteers were provided with pickup sticks, gloves and trash bags.
After completing the litter removal, Trash Bash participants dropped off their equipment at the Edward A. Dufresne Community Center, where they were provided with lunch to-go.
United Way of St. Charles, an event sponsor, offered prizes for the groups that collected the most trash. All Trash Bash participants were also entered to win an iPad and an Apple Watch courtesy of Entergy. The drawing for the raffle prizes will take place at the parish council meeting on March 15.
Trash Bash 2021 follows another parish clean-up effort earlier this month, where Jewell and Jefferson Parish President Cynthia Lee Sheng teamed up to clean up litter along Hwy 90, a highly-traveled corridor between the parishes. Staff from each parish, council members, the St. Charles Parish Sheriff's Office and the Jefferson Parish Sheriff's Office all worked to remove trash from the area.
"Keeping our parish clean and free of litter is important to our environment as well as our economy and drainage infrastructure," Jewell said. "The appearance of our parish will leave a lasting impression on all those who live, work and play in St. Charles Parish."
Jewell noted that litter negatively affects the environment and can prevent water from properly draining if it enters drainage conveyance systems, which can then lead to flooding issues.
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About Monique Roth 838 Articles
Roth has both her undergraduate and graduate degree in journalism, which she has utilized in the past as an instructor at Southeastern Louisiana University and a reporter at various newspapers and online publications. She grew up in LaPlace, where she currently resides with her husband and three daughters.