Anyone who has struggled with addiction can tell you what its like to be in the grip of the beast. We can describe the countless times we determined to quit. The plans, the promises, the pleadings, the prayers — the pain. And, then we can recount the relapses. Those heartbreaking, soul-crushing, damning relapses that proved all of our insecurities were true. Ugh!
Herein lies the kicker. There is no perfect anything. You weren't the perfect addict, you won't be perfect in recovery. Mistakes happen. Recovery is all about making the NEXT right choice.
Addiction makes you believe that there is no way back up. Your brain feels the pain and screams for you to act impulsively — to numb out the escalation. To Just. Not. Feel. When I think of this cycle a song comes to mind.
I don't think of the merry-go-round as a high-speed adventure that addiction once was. Eventually, it just becomes the master and we become the slave — until we remember this truth: Recovery is about making the next right choice.
"The Irony is that We attempt to disown our difficult stories to appear more whole or more acceptable, but our WHOLENESS — even our WHOLEHEARTEDNESS- actually depends on the integration of all of our experiences, including the falls." Brene Brown.
I love that song! It takes so much courage to still your mind enough to get to this point, but with this newfound power comes the space to heal. Self-judgement and criticism keep us locked in place. Letting go of those helps us quit pretending to ourselves and others that "we've got this" or that "it's not that bad." It just "is what it is" and as we stop beating ourselves up we create extra space in our brain to make the next right choice.
If you live in Utah County and find yourself wanting to get off of the merry-go-round and are looking to make the next right choice you can contact us. No judgments, just space to heal.


JOHANNESBURG – Power utility Eskom, which yesterday managed to curb load shedding after eight consecutive days of rolling blackouts, says it has no plans for further outages over the winter period as its systems kick into place.
Eskom said yesterday that an improvement in plant performance, with the return of five units since Friday morning, had positively shifted system performance, and it had healthy diesel and water reserves over this period.
Imports from Mozambique's Cahora Bassa have increased to 850MW, with the restoration of feed from one of the two lines, although a second transmission line would take months to repair.
According to internal reports at Eskom, there were no major planned outages, with Unit 1 at Kusile Power Station due for refuelling only in September or October, while Unit 2 has recently been refuelled and therefore was in good condition to provide power for the next 15 to 18 months until the next refuelling, maintenance and statutory inspections.
"Unit 1 has been online for 278 days and will go on a scheduled shutdown for refuelling in September or October this year. Unit 2 has been online for 88 days now after refuelling in December last year," Eskom spokesperson Khulu Phasiwe confirmed.
Eskom's stability, however, comes in the wake of media reports that the National Treasury's refusal in 2017 to extend a contract worth R275 million between the power utility and Carab Technologies, which is owned by former Eskom employees Dirk van Aarde and Fanie Scheepers, to provide software and technology to monitor boilers may have contributed to the intense load shedding that started on March 16 and ended yesterday.
The tender was reportedly halted in September 2017 as the Treasury put its foot down over lack of evidence that Carab's service could not be provided by others, or how it was appointed to do the work.
"Reports alleged that funds meant for vital maintenance of power plants were diverted to the Kusile Power Station and other capital expenditure programmes, where looting took place through dodgy tenders," DA spokesperson Natasha Mazzone said in a statement.
The previous boiler maintenance contract was also reportedly not renewed by the National Treasury, as it was an illegal tender.


text:
You are here: Home / Archives for Griffin
posted on August 6, 2013 by Administrator
Donna Distefano "Elixir of Love" ring and "The Love that Moves the Sun and the Other Stars" ring
"Our 22 karat gold and ruby Elixir of Love ring can hold your tiniest possessions. The griffin was a legendary creature with the body of lion and the head and wings of an eagle. The combination indicates both intelligence and strength. The griffin was thought to be an especially powerful and majestic creature, renowned for guarding treasures and other priceless possessions. Our griffin is carrying a Maltese cross which is considered a symbol of protection and a badge of honor representing loyalty, generosity, bravery, and helpfulness towards others. In Dante's Divine Comedy Beatrice takes off into the Heavens to begin Dante's journey through paradise on a flying Griffin that moves as fast as lightning." —Donna Distefano
See also this brief video where she discusses a ring named "The Love that Moves the Sun and the Other Stars," which was inspired by elements within the final cantos of Paradiso (the celestial rose, Mary), and the number 33. In Style magazine did a piece on it, too.
Filed Under: Consumer Goods, Image Mosaic, Visual Art & Architecture Tagged With: 2013, Beatrice, Celestial Rose, Cosmos, Griffin, Jewelry, Mary, New York City, Paradise, Stars
De Vulgari Eloquentia, the Board Game

redpajama_set_name: RedPajamaCommonCrawl


Lebanon's media are outspoken but also extremely politicized and polarized. Its newspapers, radio stations and TV channels serve as the mouthpieces of political parties or businessmen. Lebanon's criminal code regards defamation and the dissemination of false information as crimes and defines them very broadly. In 2017, the judicial authorities harassed the well-known TV host Marcel Ghanem for allowing guests to criticize the Lebanese authorities during his programme. Journalists who are prosecuted and convicted by military or print media courts are usually fined or sometimes sentenced in absentia to imprisonment. 2018 saw an increase in cases of bloggers and online journalists receiving subpoenas from the "bureau for combatting cyber-crimes" because a social network post had elicited a complaint from a private party, often a prominent person linked to the government.


text:
Riverview Fire transitioning to combination department
The Riverview Fire Department will soon be transitioning to a combination department following city council's Jan.6 approval to hire eight full-time firefighter/medics.
Chief Ron Lammers said he was very pleased with the council's decision, a proposal he has been advocating shortly after his arrival in October 2018. Once implemented, the department will be staffed with both full-time and part-time firefighters.
The Riverview Fire Department was originally established in 1923 as a civil defense Fire Force and responded to emergency calls from Ecorse to Brownstown.
In addition to basic fire protection, the department was one of the first to provide advanced first aid.
Several changes over the years have seen the department grow and progress to staffing personnel on duty 24 hours a day and 365 days a year. For many years the department has operated with part-time personnel providing fire and EMS services.
Approximately 10 years ago the department upgraded its EMS services to provide advanced life support (ALS) to its residents and visitors, following the trend of other surrounding departments.
With the construction of various multi-occupancy dwellings in the community, the department's call volume has increased substantially over the years.
In 2005, the department's call volume was approximately 1,700 runs. In 2018, it topped out at 3,021 runs. As a result the long standing department model is no longer viable given the growth of the city.
This, along with providing a better, more efficient service to the community, is what prompted the necessity to begin the transition to a full-time fire/EMS service.
Chief Lammers said there is still much to be done prior to the implementation of the program.
"I would prefer to hire or fill those eight positions from within the department," he said.
However, conditions of employment, wages and benefits must be negotiated between the city and bargaining unit first, which Lammers hopes can be resolved as quickly as possible. In the meantime, the city is in the process of contracting ALS ambulance services while details are worked out.
The city also continues to seek qualified applicants.
Chief Lammers said there is also a need for part-time firefighters as well. Interested candidates may obtain an application by going to the city manager/mayor's office or online at the cityofriverview.com, fire department and click on the application link at the top of the page.
Previous Riverview to welcome The Wall that Heals
Next Designer draws from many influences


Apr 03, 2017 · Workers make preparations to lift the cutting head from Bertha, the world's largest tunnel-boring machine, and lift it out for repairs in Seattle, Washington March 9, 2015.
Bertha, the world's biggest tunnel-boring machine currently underneath Seattle, has been stuck for nearly one month. Now, crews are close to figuring out what exactly is stopping her.
Russian operator company NCC (Nevskaya Concession Company) has placed an order with German manufacturer Herrenknecht for the world's largest tunnel boring machine (TBM).
Named after one of Seattle's early mayors, the $80 million drill Big Bertha is 326 feet long, weighs 6,700 tons, and does much more than drill. John Blackstone reports on what the high-tech machinery can do, as well as its latest challenge digging in the depths of Seattle.
world's largest tunnel boring machine. We are the manufacturer of coal mining machine,roadheader,coal loader,tunnel mucking loader,backfilling machine,concerte pumping machine and so on. world's largest tunnel boring machine manufacturer, supplier.


When you look to hire an exotic car for your trip, it's better to consider the season for your trip. Most exotic cars are not rented during winter. But during summer there are a number of exotic cars and racing events everywhere, this is the best time to make such a trip using exotic cars. The cars come in various models and types and so does the price. It's better to spend that huge sum of money but get the fulfillment of a lifetime that you are looking for.
Below are three types of such exotic cars that will leave you yearning for another such a trip. The list has but in mind the factors like comfortability, tech, fuel consumption, and reliability. Since it's a road trip then speed will be a concern too.
We all know how the Aston Martin model the best bodies, stylish and biggest engines on their sportiest car chassis. This car will not only shorten your travel time, fuel usage but provide with a comfortable and amazing experience. The car can handle sharp corners and sharp curves without throwing you off the sit. Provides you a hand-stitched sits with a sound system like no other.
This is another ride that will make you extend your road trip by days. It commands the road with its high and luxurious conveyance with the best leather the British can offer, not forgetting the wood in the interior. If you are looking to go off-road, then this machine will make the ride seem like a walk through. With its supercharged V-8 power the ride will not only leave you amazed but fulfilled. It also provides you with plenty of space for your cargo.
This one evocative convertible to be put on the road. With its amazing sound system, its body design, its fast, refined, agile. Its suspension can be tuned to fit the surface you drive on. This ride is beautiful in every way with its V8 powered and gives an experience like no other any time you put your finger on the start button. This car will not only get you there fast but comfortably too.
Having talked about the three rides, you have chosen your desired ride. All you need is to find the best hire services around you that offer these type of vehicles. Consider their client relationship and track record of services. Strick a deal and set a date to begin your trip. Consider the places to visit and the number of friends or family you will be traveling with. Put in mind your safety first when you hire an exotic car. Since most of them are so fast.
Ever found yourself in a tight corner as far as the parking of your car is concerned? Am so much pretty sure that you were merely frizzled by the fact that only a small place was set aside for the parking of your car and therefore you had no otherwise but to try out your shaky parking skills notwithstanding! Am convinced that you managed to perfectly park your car at the small and tight place that was available with no reported incidences of a bent fender, ain't you? well with this article the hustle will a be long gone case if Best cars with self-parking systems is anything to go by keeping car rental comparison in mind.
How do this technology work?
Can you picture a scenario whereby you have arrived at a scheduled meeting after many hours of delay due to snarl-ups? On arrival, you find nearly all your colleagues have already made their way in and parked their cars all over the place and the only opportunity left for you is a small space left adjacent to other severally parked cars that for you to really use it you must have some super skills to access it. With a car having this kind of technology it will save you the hustle in such situations since it will park itself. Surprised! Okay, this is how it works, you as the owner all you require is to press a specified button that initiates the command while you keep your calm and watch you car parking itself saving you the pulling of back and forth, meandering to get it perfect in place.
Example of these types of cars.
The automobile manufacturers have established the rising demand in this type of cars and they have moved swiftly to try and bridge the gap by making available to the market different makes as will be listed going ahead.
This car is considered one of the finest well-done jobs by the manufacturers if the recent upgrades are anything to go by. The car is endowed with every necessary feature that helps you not only park your car but also helps you out of the bay.
The c- class is one of the most sophisticated cars that is fitted with all manner of fancy and expensive components. The alloy rims, if not it could be the side mirror et cetera. Who wouldn't mind that all this sumptuously designed toy is messed up due to the parking lapse? Therefore this is one of the cars that have this type of technology working in it to help it detect whether the parking space is appropriate and therefore take the necessary maneuvers and steering control for successful parking.
Now that all this information is known to you I believe it will play a great part in your choice of the best car in the event you find yourself at a car rental comparison dilemma.
Though travelling is a fun and pleasurable experience, it can quickly turn into a stressful endeavor if things do not go as planned. Even the best of plans can quickly fail if you do not start planning earlier enough.
Choosing a rental car is the first and the most important step that will help you ensure a hassle-free travel experience. With some careful planning and research, you will be able to find a suitable car from a rental24h shop according to your needs.
Follow these tips to find the perfect car for your trip and ensure a stress-free travel experience!
Are you looking for a luxurious travel experience?
Does comfort come first for you?
Are you going to travel long distances?
Will you be carrying a lot of luggage with you?
You need to evaluate your needs first before going onto choosing a specific car. These questions will help you find an ideal car deal. If you have a large family or are carrying loads of luggage with you, you need to opt for a SUV or a similar vehicle with more room to accompany your family members and luggage. In case you have to travel long distances, it might not be a good idea to choose a luxurious car. If you are going with aged members of your family, you may need to opt for a comfortable car.
If your travel destination has a lot of narrow roads, it might not be a good idea to choose a larger vehicle since these are pretty hard to maneuver. Also, they might cost you a lot more than mini-vehicles when on the pump. You need to weigh your pros and cons effectively in order to arrive at the right decision.
Moreover the term "compact" may not be the same for every country. Not all compact cars will be of the same size. If you are not carrying a lot of luggage and have limited family members, it is recommended to go for a medium-sized car, as they tend to be a lot less expensive than larger vehicles.
If you have been driving an automatic car for the longest of time, chances are that you wont be able to manage a manual car. Since manual cars require a lot more work, discuss this with your rental agency beforehand in order to avoid any inconveniences later on. Rental agencies are often short on automatic vehicles since the demand is quite high; therefore make sure to put in your request as early as possible.
What are the penalties or liabilities?
What additional services are they providing you (GPS)?
Do they have any restrictions?
These tips will help you find the perfect car from a car rental agency, ensuring a smooth travelling experience for all your family members!
There is just nothing like a good old great American road trip. If you have a true sense of adventure there is truly no other way to see this magnificent country thank by packing your bags, filling the gas tank and hitting the road.
Yes, holidaying in the Caribbean or Bali and other exotic places is good, but this country is so vast, with so much to see, you can have many similar experiences without leaving the shores of the US. So, let's plan the ultimate road trip to ensure we get as wide an experience as possible.
There is so much to choose from the natural swimming springs in Texas to Washington State with its breathtaking mountains and Arizona with the captivating canyons and trails to explore.
Based on our research we have chosen as the 5 best places to go to.
It's time for the ultimate US road trip.
There is so much to do in Jackson Mountain, with whitewater rafting,horseback riding,hiking and even golfing and are but a few of the activities during the Summer months. There areso many outdoor and varying activities including hot air ballooning,kayaking, stagecoach ridesmountain biking andhang gliding.The Grand Teton National Park is absolute bliss for climbers, hikers and nature lovers.
Jackson Hole, situated in a valley, overlaps with Grand Teton National Park.So, if you love magnificent natural panoramic views, this is the place for you.
During the winter, the snowcapped mountains for skiing is no less magnificent.
No road trip would be complete without the grandeur of this truly awesome place; regarded by many as one of the most magnificent sights in the world.
The Grand Canyon, carved over many years by the Colorado River, isup to 18 miles wide, 277 miles long, and has a depth of over a mile. A steep-sided canyon with glorious view, from all angles, the Grand Canyon is really one of the world's great wonders.
With it's enormous expanse of gorges, ridges and rock formations you could not hike through this vast space if you had several days, so pick you spots. And don't forget the rafting.
Located on the Arizona–Utah border Monument Valley is a area of the Colorado Plateauwhich has a group of vast sandstone buttes, of red earth. With the largest formationbeing 1,000 ft high, above the valley floor, this attraction is accessible from U.S. Highway 163and lies within the territory of the Navajo Nation Reservation.
With its magnificent backdrop, Monument Valley is one of the most majesticlandscapes of the American West. Its beauty is so dramatic it is also one of the most popular landscapes for photographs.
The Hamilton Pool preserve is home to a variety of native animals, birds, fish, and plants and is a historic swimming hole located in Dripping Springs, Texas.
One of the magnificent features is where the 50-foot natural waterfall is created where Hamilton Creek spills out over limestone outcroppings. The Pool is therefore ideal for picnicking, swimming or just relaxing.
Note that reservations are required if you want to visit the Hamilton Pool-Preserve during peak summer months of May-September.
This magnificent structure is the oldest lighthouse in Maine, with its rock shoreline right up to the water's edge. In addition to the enthralling history behind the lighthouse you will really enjoy the views at sunset. As the evening sun sets there is a rosy light reflects on the water and turns the white lighthouse into a dusty shade of pink. This view makes truly beautiful photographs.
Each of these have its own beauty and attraction and difference.
At the end of this trip, all you will ask is 'when is the next road trip?' We enjoyed so much beauty, such splendor, and had so much fun. There is no truer American way to holiday but by car. And having our car from Rental24h made life so simple. All we had to do was gas it up.


Experience cutting–edge website hosting at an affordable price with the KVM virtual private servers from GESIC Computers USA. We provide top server security, with one full backup per week. Our servers also offer impressive hosting conditions for all your websites with dedicated CPU allocation and SSD data storage. An array of OSs is offered.
If you need a different web hosting configuration, why not have a look at the other plans we have?
Normally, VPSs need an additional communication layer between them and the physical server to deal with system resource management. This leads to a notably lowered amount of available resources for the virtual servers themselves. With KVM, this additional layer is eliminated, since the virtualization platform itself is embedded directly into the physical host server's Operating System. Therefore, all the resources offered by the physical host server can be utilized by the KVM-driven virtual machines that have been set up. This resource availability gives you that extra advantage you require to make your websites and web applicationsclearly distinguishable from your competitors'.
Among the downsides of virtual servers as compared with dedicated servers is the OS itself – you are ordinarily confined by the Operating System options offered by your provider. However, with a KVM virtual server you can use practically any OS that is supported by your server's technical specifications and the hardware of the physical server. This is possible due to the specific way in which KVM virtualization works. KVM is built straight into the host OS kernel itself, making it possible for virtual machines to interact directly with the hardware components, without needing to use an additional communication layer, present in many other server virtualization alternatives.
Each KVM VPS server made available from GESIC Computers USA is equipped with extremely fast SSD drives. They enable quicker data file admission and a lot speedier read/write rates in comparison with the common harddrives. In reality, these SSD disks will certainly make your website pages operate much faster. And you won't have to modify anything to be able to take full advantage of the advantages delivered by the SSD disks.
What the enormous majority of server virtualization techniques include is a 'middleman' between the virtual machine and the actual host, which handles resource management. The most important advantage of employing a KVM-powered VPS is that the KVM technology is integrated directly into the kernel of the physical host server's Operating System, in other words – additional software programs aren't necessary – the virtual server interplays directly with the host server. This means a lot fewer overheads and a noticeably faster performance.
In the event you have to deploy a web app for your web page but have no clue precisely how to do so or if you face a very difficult problem with your website that you do not know how to address, you are able to benefit from our Setup & Troubleshooting services. Our staff will help you add various software application that you wish and will do their very best to solve any web server situation that you may possibly have in a matter of minutes.
You are able to pick a Linux distribution – Ubuntu, Debian or CentOS with all of our KVM virtual private servers.
Having full root admission to the KVM VPS server, you could become an administrator of your own personal hosting server environment. Such connectivity means that you can install an OS or edit the Apache hosting server configuration. You could also install all types of software applications and restart the machine whenever you like. Using our Installation & Troubleshooting pack, you could leave all this work to our well–trained executives.
Our team of skilled specialists will be available for you twenty–four–seven to support you with your VPS. For example, if you must overcome unforeseen service disruptions or would like to install certain software package on your VPS, our experts will help you out. You can make contact with our company whenever you want – our support crew is readily available 24 hours. A 1–hour answer warranty is also featured.
Our system administrators are working in partnership with the technical engineers at our data center in the United States to provide a reliable platform for your VPS. In our datacenter in the US we also deploy the most recently released server equipment and security applications on the market to guarantee a 99.9% uptime for your digital system.
With every single KVM VPS server, you will be given a dedicated IP address at no extra cost.
Your KVM VPS server will be set up in about 1 hour after sign–up. We don't bill you any set–up service fees, so the price tag you see on our website is the end worth for the VPS. We have invested time and effort in setting up our own internal networking and we can now warrant a 99.9% system uptime for your VPS. If you ever require help with any of the pre–installed in advance apps, you are able to make use of our support service round–the–clock.
Your KVM VPS server will be equipped with an extensive set of characteristics for dealing with your ever–demanding web presence. You'll be allocated SSD storage space, as well as warranted server processing power and storage resources for running your media–intensive webpages. Also, you'll get a free of cost dedicated IP and a range of cost–free resources to initiate your own private reseller hosting business, including a domain name reseller profile plus a help and support & payment software application setup. Additionally, your KVM VPS server will be based on an all–powerful control web server that will assure a secure platform for building and taking care of web presence.


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Oct. 15, 2014 | 12:20 PM
ISIS presses gains in Syria, Iraq
Smoke rises from the Syrian town of Kobani, seen from near the Mursitpinar border crossing on the Turkish-Syrian border in the southeastern town of Suruc in Sanliurfa province October 15, 2014. REUTERS/Kai Pfaffenbach
Burak AkinciRana Moussaoui| Agence France Presse
Anbar
Baiji
Aref Al-Janabi
Badr Shiite
Syrian Observatory
Jihadists pushed to seize Syria's Kobani and an Iraqi town close to Baghdad Wednesday as Washington warned of a long fight against the steadily advancing ISIS.
In Iraq, ISIS militants were closing on the town of Amriyat al-Fallujah, one of the last still controlled by the government in the troubled Anbar province and only 35 kilometers (20 miles) from Baghdad.
Obama expressed special concern for Kobani, which has become a crucial symbolic battleground in the fight against ISIS, and about halting the ISIS advance in Iraq's western Anbar province.
Fighting continued to rage for Kobani early Wednesday, with clashes concentrated in the east of the town where ISIS fighters established a stronghold after piercing its defences last week.
If the town were to fall, ISIS fighters would still have to capture a significant stretch of government-controlled land before reaching the capital.
But the loss of Anbar, where government forces have suffered a string of bruising military setbacks in recent weeks, would be a heavy blow to Iraqi ground forces battling ISIS.


text:
package com.annimon.tsvc.tasks;

import javafx.concurrent.Task;

/**
 * Join {@link PartialTask} tasks.
 *
 * @author aNNiMON
 */
public final class TaskJoiner extends Task<Boolean> implements TaskListener<Boolean> {

    private final PartialTask[] partialTasks;

    public TaskJoiner(PartialTask... tasks) {
        this.partialTasks = tasks;
        for (PartialTask task : tasks) {
            task.setListener(TaskJoiner.this);
        }
    }

    @Override
    protected Boolean call() throws Exception {
        for (PartialTask partialTask : partialTasks) {
            partialTask.call();
        }
        return true;
    }

    @Override
    public void updateTaskValue(Boolean value) {
        updateValue(value);
    }

    @Override
    public void updateTaskTitle(String title) {
        updateTitle(title);
    }

    @Override
    public void updateTaskMessage(String message) {
        updateMessage(message);
    }

    @Override
    public void updateTaskProgress(double workDone, double max) {
        updateProgress(workDone, max);
    }

    @Override
    public void updateTaskProgress(long workDone, long max) {
        updateProgress(workDone, max);
    }

    @Override
    public boolean isTaskCancelled() {
        return isCancelled();
    }

}

redpajama_set_name: RedPajamaGithub


text:
Japan's recent heavy snow has caused 13 deaths, many injuries
Recent heavy snow in Japan's north and elsewhere have killed 13 people injured more than 80 and left more than 10,000 households without power, the authorities said on Saturday.
Snowstorms and high waves in northern Japan and along the Sea of Japan coast could cause snow as deep as 60 cm (two feet), the Meteorological Agency warned.
By late Saturday afternoon, more than 30 had been seriously injured and more than 50 sustained minor injuries, the Fire and Disaster Management Agency said.
Train and airplane services were disrupted in northern Japan, and some parts of central and western areas experienced traffic disruption, according to public broadcaster NHK.


Switzerland 1982 Europa : Historical Events 2 value set depicting the Treaty of 1291 founding the Swiss Confederation and "Swearing Oath of Eternal Fealty, Rutli Meadow" (detail of mural, Heinrich Danioth) - in superb u/m (mnh) condition - excellent country, history, heritage, writing, art, artists thematics. If you cannot find the specific stamp set or thematic/topic you are looking for either here in my shop or at the brumstamp stamp shop on eBay http://stores.shop.ebay.co.uk/The-Brumstamp-Stamp-Shop please do not hesitate to contact me. Enjoy browsing and shopping. Andrea!


Old buildings on the verge of collapse, winding, empty streets, skeletal structures and hidden lanes and alleyways. Ruins dominate the city and make up the majority of its landscape.
Exploration is dangerous…but it might be rewarding, too.
One of the streets has buckled inwards. Clearing the rubble away has revealed the entrance to a hidden cave system.


text:
<!DOCTYPE html>

<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1">
<title>Extractor web version</title>

<link rel="icon" type="image/png" href="favicon1616.png" sizes="16x16" />
<link rel="stylesheet"
	href="./bower_components/bootstrap/dist/css/bootstrap.min.css" />
<link rel="stylesheet"
	href="./bower_components/bootstrap/dist/css/bootstrap-theme.min.css" />

	<form ng-submit="postExtractionJSON(myAtlas.id)">

Extractor Web version

Atlas selection

					Select ATLAS:
					<select	class="input-xxlarge"
						ng-model="myAtlas"
						ng-options="item.atlas for item in items"
						ng-change="update(myAtlas)">
					</select>

Contrasts

Anat

BOLD

Correlation

Corr Anat

Corr BOLD

Anat

												<input type="checkbox"
													ng-checked="extraction.anatcon.indexOf(x) > -1"
													ng-click="toggleSelAnatCon(x)" value="{{x}}"> {{x}}

BOLD

												<input type="checkbox"
													ng-checked="extraction.boldcon.indexOf(x) > -1"
													ng-click="toggleSelBoldCon(x)" value="{{x}}"> {{x}}

Correlated Anat

												<input type="checkbox"
													ng-checked="extraction.corranatcon.indexOf(x) > -1"
													ng-click="toggleSelCorrAnatCon(x)" value="{{x}}">
												{{x}}

Correlated BOLD

												<input type="checkbox"
													ng-checked="extraction.corrboldcon.indexOf(x) > -1"
													ng-click="toggleSelCorrBoldCon(x)" value="{{x}}">
												{{x}}

							<form name="myForm">

Custom contrast

Formula (SPM type, e.g. i1+i2):

								<input type="text" name="input" ng-model="extraction.custom">

Contrast name:

								<input type="text" name="input" ng-model="extraction.customname">

									 Required!
									 Single word only!

							</form>

Regions

											 <input type="checkbox"
												ng-checked="extraction.roi.indexOf(x) > -1"
												ng-click="toggleSelectionRoi(x,myAtlas.id)" value="{{x}}">
												{{x}}

											 <input type="checkbox"
												ng-checked="extraction.bisroi.indexOf(x) > -1"
												ng-click="toggleSelectionRoiBis(x,myAtlas.id)" value="{{x}}">
												{{x}}

									 <input type="checkbox"
										ng-model="extraction.asymmetry" ng-click="updateRoi()"> Asymmetry

											 <input type="checkbox"
												ng-checked="extraction.roi.indexOf(x) > -1"
												ng-click="toggleSelectionRoi(x,myAtlas.id)" value="{{x}}">
												{{x}}

									 All ROI's   Left Hemi.   Right Hemi.

					<input type="submit" value="Submit"
					class="btn btn-primary"/>

	</form>


Old Spice Men'S Deodorant Reduces Underarm Odor For 24 Hours. Turn The Base To Raise The Deodorant And Wipe Armpits For Long-Lasting Freshness. What'S Better Than Smelling Like Man? I'M So Glad You Asked, Because The Only Thing Better Than Smelling Like A Man Is Smelling Like A Man Who Knows How To Smell Manly. I'M Talking About The Sophisticated Scent Of A Man Who Uses Old Spice. Fresh Is The Ever-Impressive Scent Of Clean Citrus. Old Spice Men'S Deodorant Overpowers Even The Burliest Stink With Overwhelming Good-Smellingness.


text:
iheartberlinfilm
a documentary about Berlins made in the USA
HALLO AND HOWDY!
We are an international team of filmmakers and have been working on the feature-length road-trip-documentary I (HEART) BERLIN for almost three years. I (HEART) BERLIN is the first movie to show and document German-American culture to an old and young audience all over the world. Our film takes you to 14 different Berlins in the United States introducing their American inhabitants. From the largest Amish community in the United States, Berlin, Ohio, via Berlin, Massachusetts to New Berlin, Texas: on this journey you will meet the most amazing people: a cowboy, a linguistic professor, a fighter jet pilot instructor, a dairy farmer, a speech writer, a funeral home owners and many more.
All having one thing in common: German roots.
Our director, Anke Schiemann, who just recently produced the award winning mixed animation live action film, Paper Daydream, which won prizes at festivals in New York, Washington, and London, picks up the trail with American Berliners: What informs American Berliners identification today? How important are roots? What remains of their German-ness?
View the trailer for our documentary here!
In July 2013 we completed the shooting of I (HEART) BERLIN. We were invited to show a short version at the opening of the exhibition "Berlins –Made in the USA" at the German American Heritage Museum in Washington D.C. this summer, on the occasion of the 50th anniversary of John F. Kennedys "Ich bin ein Berliner" speech. Plenty of Berliners from all over the US participated in the event which we covered to be part of our final documentary.
(below in the pictures you see the director of the museum, Rüdiger Lentz introducing the film together with the director of I (HEART) BERLIN, Anke Schiemann.)
Starting and ending in Berlin, the capital of Germany, the story is told through personal stories of German descendants and German migrants. Those portraits will be intercut with the director's own personal story of migration, dislocation and re-location.
On the road we will make plenty of acquaintances like:
We meet Maria Schlabach, a former member of the Amish community of Berlin, Ohio (the largest such community in the United States), who was ostracized from her community two years ago and gives us important insights into the daily life of an Amish woman and the popular myth of Rummspringerl.
In Berlin, Georgia we meet Inge Fischer, who after being imprisoned for critizising the current regime, fled East Berlin on the night of Stalin's death, migrating to the United States on one of the first commercial flights.
We then meet Stewart Saylor from the Historical Society in Berlin Somerset. His ancestors arrived on a ship in 1749 and belong to the first wave of German migrants to Pennsylvania. Stewart got his family DNA analysed and can track back his German heritage to the Lichtenstein cave in the Harz mountains 3000 years ago.
We'll sit down for a cup of coffee at Brietzke's Café. A New Berlin, Texas institution owned by Evangeline, better known to her friends and neighbours as Mutsie. The Hessian settlement was established in the early 1840ies by five princes and sixteen noblemen who formed an organization known as the Adelsverein, with the purpose of establishing german settlements in Texas. Mutsie's great grandparents came to Texas with this early aristocratic settlers.
In Berlin, Massachusetts one of the oldest Berlins in the United States, we get to know Kai von Fintel. Kai spent 10 years of his life planning and building an eco-village in Berlin. Kai is also a professor for linguistics at MIT. Kai represents the most recent migrant on the trip. Kai only came over to the USA 20 years ago.
…Of course there are plenty more Berliners featured in our film. Be part of I (HEART) BERLIN!
I (HEART) BERLIN im
"BERLINS MADE IN THE USA"
LIKE US AND BE PART OF IT!
I HEART BERLIN now available on Amazon Prime!
FINALLY FINISHED!
Its Berlinale time!
I (HEART) BERLIN mit Ingo Hoppe on RADIO BERLIN
I (HEART) BERLIN on RADIO EINS!


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Adopted in 1976, the Orangeville BIA (OBIA) was created in and effort to build a stronger business area in an era when traditional downtowns began the struggle to compete against malls and plazas. Its goal was to bring independent business people together to build a stronger business area. The OBIA currently represents over 230 businesses in the downtown area, from Lakeview Court and the Best Western in the east all along Broadway to Faulkner St. and Cunningham Vacuums in the West and includes all, or portions of, several side streets in between.
The OBIA is mandated with developing the downtown through beautification, general improvements and upgrades, promotion, events and marketing; to advocate on behalf of the interests of the business improvement area and to undertake strategic planning as necessary to make improvements to the Area.
The goal of the OBIA is to make Downtown a place that exudes small town charm in a vibrant social and cultural business centre. Specifically, the Orangeville BIA is responsible through By-Law #23-78, for: "To oversee the improvement, beautification, and maintenance of municipally owned lands, buildings and structures in the area beyond that provided at the expense of the Corporation of the Town of Orangeville and to promote that area as a business or shopping area." In essence, the OBIA is a self-help business organization supported by the municipality.
While a BIA arises from the retail and professional activities of a main street, it has a profound effect on the surrounding area. It serves as an economic and social anchor, helping to stabilize and revitalize the local community. For the municipality, it is an opportunity to strengthen the municipal tax base, halt the deterioration of surrounding neighborhoods, and improve the municipality's image.
The value to the members of a BIA is precisely that it provides a mechanism for organizing and financing programs that would not be available to independent people by any other means. Most of the businesses within the OBIA boundaries are small, independently owned and operated retail stores, restaurants or services. The OBIA makes it possible for these businesses to beautify their streetscape, making visiting their place of business more enjoyable for their customers, it provides for more cost effective advertising opportunities so these businesses can reach a wider audience, and provides administrative support as well as strategic planning with the future in mind. All businesses within the improved area reap the benefits of these improvements whether directly or indirectly.While not all businesses benefit directly from every initiative, all businesses within the BIA benefit from being located in an area that is attractive and prosperous.
The OBIA provides great rewards; increased traffic, sales and profits, a more successful and active business environment, a more beautiful community, and a restored sense of civic pride. A downtown that is thriving and prosperous is an essential element in a healthy local economy. Downtown is the heart of our community, and by strengthening the downtown area, the OBIA helps to create a vibrant place to live, to work, to do business, and to spend some free time.
As part of our mandate, the OBIA hosts events which focus on the promotion of Downtown Orangeville as a shopping, dining and business destination for locals and tourists alike. These events include the weekly (May to October) Market on Broadway, Founders' Fair & Sidewalk Sale in July, Harvest Celebration in October, and the Moonlight Magic & Tractor Parade of Lights in late November. We also sponsor/ support the Orangeville Blues & Jazz Festival, Theatre Orangeville and other community events as these provide us with the opportunity to promote the downtown area and help to maintain Orangeville's strong sense of community and history.
Quite simply, the Orangeville BIA is based on the principal that together we can accomplish more than we can alone. We believe that the best way to protect our downtown's heritage is to look to the future. The OBIA believes that a vision of a vibrant, prosperous Orangeville must include a thriving Downtown. To achieve that, local, small businesses and commercial property owners must work together to encourage locals and tourists to do business in our beautiful downtown. The OBIA serves as the vehicle that drives Orangeville's downtown in that direction. Our goals are long term as we look to the coming decades and the need for a strong, healthy local economy.
Our strength is in the commitment and support of our members.


text:
ADA Standards of Medical Care
Special Article Collections
Epidemiology/Health Services/Psychosocial Research
Fulminant Type 1 Diabetes
A nationwide survey in Japan
Akihisa Imagawa, MD1,
Toshiaki Hanafusa, MD2,
Yasuko Uchigata, MD3,
Azuma Kanatsuka, MD4,
Eiji Kawasaki, MD5,
Tetsuro Kobayashi, MD6,
Akira Shimada, MD7,
Ikki Shimizu, MD8,
Tetsuya Toyoda, MD9,
Taro Maruyama, MD10 and
Hideichi Makino, MD11
1Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
2First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
3Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan
4Diabetes Center, Kasori Hospital, Chiba, Japan
5Unit of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
6Third Department of Internal Medicine, University of Yamanashi School of Medicine, Nakakoma, Japan
7Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
8Ehime Prefectural Central Hospital, Internal Medicine, Matsuyama, Japan
9Department of Virology, Kurume University School of Medicine, Kurume, Japan
10Department of Internal Medicine, Saitama Social Insurance Hospital, Urawa, Japan
11Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan
Address correspondence and reprint requests to Toshiaki Hanafusa, MD, PhD, FACP, Professor and Chairman, First Department of Internal Medicine, Osaka Medical College, 2–7 Daigaku-machi, Takatsuki, 569-8686, Japan. E-mail: hanafusa{at}poh.osaka-med.ac.jp
Diabetes Care 2003 Aug; 26(8): 2345-2352. https://doi.org/10.2337/diacare.26.8.2345
OBJECTIVE— To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey.
RESEARCH DESIGN AND METHODS—History and laboratory data, including islet-related autoantibodies, were examined in 222 patients with fulminant and nonfulminant type 1 diabetes in our hospitals in addition to another 118 patients with fulminant type 1 diabetes located outside our hospitals in Japan.
RESULTS—In our hospitals, of the 222 patients studied, 43 (19.4%) were diagnosed with fulminant type 1 diabetes, 137 (61.7%) were classified as having autoimmune type 1 diabetes, and 42 were type 1 diabetic subjects who were not fulminant and did not have anti-islet antibodies. An additional 118 fulminant patients outside our hospitals were enrolled, making a total of 161 fulminant type 1 diabetic subjects (83 male and 78 female subjects; 14 children/adolescents and 147 adults) identified from all over Japan. (In 2000, the average incidence was three cases per month.) Flu-like symptoms and pregnancy were more frequently observed in the fulminant than in the autoimmune group (P < 0.001). In the fulminant patients, 4.8% were positive for anti-GAD antibodies and none were positive for anti–islet antigen 2 antibodies.
CONCLUSIONS—Fulminant type 1 diabetes is a distinct subtype and accounts for ∼20% of the ketosis-onset type 1 diabetes cases in Japan. Flu-like symptoms are characteristic of disease onset. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes.
ADA, American Diabetes Association
ALT, alanine aminotransferase
AST, aspartate aminotransferase
GADAb, GAD antibody
IAA, insulin autoantibody
IA-2, islet antigen 2
IA-2Ab, IA-2 antibody
ICA, islet cell antibody
WHO, World Health Organization
Type 1 (insulin-dependent) diabetes is characterized by insulin deficiency from the destruction of pancreatic β-cells. According to the recently proposed classification of diabetes by the American Diabetes Association (ADA) and the World Health Organization (WHO), type 1 diabetes is divided into two subtypes: autoimmune type 1 (immune-mediated; type 1A) diabetes and idiopathic (type 1B) diabetes (1,2).
Since 1974, when Bottazzo et al. (3) reported the presence of islet cell antibodies (ICAs) in the sera of type 1 diabetic patients, several autoantibodies to pancreatic islet cells have been recognized as a marker of type 1 diabetes. These islet-related autoantibodies are anti-GAD antibodies (GADAb), insulin autoantibodies (IAA), and anti–islet antigen 2 (IA-2)/IA-2β antibodies (4,5).
However, type 1 diabetic patients are not always positive for these autoantibodies, even at the onset of overt diabetes (6,7). Patients with type 1 diabetes who do not have islet autoantibodies at the time of diagnosis are classified as having idiopathic or type 1B diabetes. In Japan, several cases have been reported in which islet-related autoantibodies were negative and the onset of diabetes was acute (8–12). Imagawa and colleagues (13,14) have proposed that these cases are "nonautoimmune fulminant" type 1 diabetes. The clinical characteristics of this subtype of type 1 diabetes are 1) remarkably abrupt onset of disease; 2) very short (<1 week) duration of diabetic symptoms, such as polyuria, thirst, and body weight loss; 3) acidosis at diagnosis; 4) negative status of islet-related autoantibodies, such as ICA, GADAb, IAA, or anti–IA-2 antibodies; 5) virtually no C-peptide secretion (<10 μg/day in urine); and 6) elevated serum pancreatic enzyme levels (13).
To clarify the more detailed clinical and immunologic characteristics of fulminant type 1 diabetic patients, we performed a multicenter study and a nationwide survey under the auspices of the Japanese Diabetes Society.
Study 1.
Inclusion criteria for fulminant type 1 diabetes in this study were 1) ketosis or ketoacidosis within a week after the onset of hyperglycemic symptoms; 2) urinary C-peptide excretion <10 μg/day, fasting serum C-peptide <0.3 ng/ml (0.1 nmol/l), or serum C-peptide <0.5 ng/ml (0.17 nmol/l) after glucagon injection or meal load soon after disease onset; and 3) HbA1c <8.5% on the first visit. These criteria were determined based on the data from the first 11 patients diagnosed with fulminant diabetes, as reported by Imagawa et al. (13).
First, using retrospective review of patient records, we identified all patients diagnosed with type 1 diabetes who visited the Internal Medicine section or the Diabetes Center in the participating hospitals from 1991 through 2000. Participating hospitals were Osaka University Medical Hospital, Osaka Medical College Hospital, Hospital of Tokyo Women's Medical University School of Medicine, Nagasaki University Hospital, Nagasaki Genbaku Hospital, Sasebo-Central Hospital, Kosei-kai Hospital, Nijigaoka Hospital, Toranomon Hospital, Keio University Hospital, Saiseikai Central Hospital, Ehime Prefectural Central Hospital, Saitama Social Insurance Hospital, Ehime University Hospital, South-Matsuyama Hospital, Matsuyama Municipal Hospital, Central Saijo Hospital, and Matsuyama Red-Cross Hospital. Next, we identified all acute-onset type 1 diabetic patients with ketosis or ketoacidosis at onset who met nos. 1–4 or 1–3 plus 5 of the following criteria: 1) presence of ketosis or ketoacidosis at the onset of diabetes, 2) duration of hyperglycemic symptoms before insulin therapy of <3 months, 3) required insulin replacement therapy at both onset and 6 months after onset, 4) presence of at least one islet-related autoantibody (GADAb, ICA, IAA, or IA-2 antibody [IA-2Ab]), and 5) decreased insulin-secreting capacity (urinary C-peptide excretion <20 μg/day, fasting serum C-peptide level <0.4 ng/ml [0.13 nmol/l], or peak serum C-peptide level <1.0 ng/ml [0.33 nmol/l] after glucagon or meal load). Of the 222 patients who were thus identified with acute-onset type 1 diabetes in our hospitals, we determined that 43 had fulminant type 1 diabetes using the criteria described above.
First, we asked all members of the Japan Diabetes Society through direct mail and the Journal of the Japan Diabetes Society if they knew of candidates who fulfilled the criteria of fulminant type 1 diabetes, as described above. To those who responded positively, we sent a questionnaire asking for a description of the patients' clinical characteristics and autoantibody status, as described herein. The criteria used to determine fulminant type 1 diabetes were the same as those used in Study 1. Through this method, we identified 229 candidates and confirmed 118 patients among them.
The 118 patients from the Japan Diabetes Society survey and the 43 patients identified in study 1 (total 161 patients: 83 male and 78 female patients) were diagnosed with fulminant type 1 diabetes and comprised the subjects of study 2.
Clinical characteristics.
Clinical characteristics of all patients (age at onset, sex, BMI, date of onset of hyperglycemic symptoms, date insulin therapy was started, family history of diabetes, symptoms accompanying onset of diabetes, and diabetic complications) were recorded. In addition, dosages of daily insulin injection and the following laboratory data were determined at 0, 3, 6, and 12 months after the onset of diabetes in each hospital: plasma glucose concentration; HbA1c level; urinary ketone bodies; serum ketone levels; arterial pH; serum concentrations of sodium, potassium, chloride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, and triglyceride; daily urinary C-peptide excretion; fasting serum C-peptide level; and serum concentrations of amylase, elastase-1, and lipase. Ketosis was determined by ketonuria, elevated serum ketones, or both.
Autoantibodies.
GADAb, ICA, and IA-2Ab were determined at the onset of diabetes. If no data were available, but serum samples stored at the time of diagnosis were available, autoantibodies were examined retrospectively. GADAbs and IA-2Abs were measured by radioimmunoassay or radioligand-binding assay (15) and ICAs were measured by the immunohistochemical methods. Thyroid anti-microsomal and anti-thyroglobulin antibodies were also investigated.
Statistical analysis was performed with Fisher's exact probability test, the Mann-Whitney U test, and the unpaired or paired t test, as appropriate.
In our 18 hospitals, 222 patients (102 male and 120 female) were diagnosed with acute-onset type 1 diabetes with ketosis at disease onset. Of these 222 patients, 43 (19.4%) were diagnosed as having fulminant type 1 diabetes, including 27 male and 16 female patients. Among the remaining (nonfulminant) 179 patients, 137 (47 male and 90 female patients) were positive for at least one islet-related autoantibody. Of those 137 patients, 117 patients were positive for at least GADAb, another 17 were positive for at least ICA, and the remaining 3 were positive for at least IA-2Ab. We diagnosed these patients as having autoimmune type 1 diabetes. There was a significant difference by sex between fulminant and autoimmune type (P = 0.001); 62.8% of fulminant diabetic patients were male vs. only 34.3% of autoimmune diabetic patients. The final 42 patients (28 male and 14 female) were diagnosed with type 1 diabetes, but were negative for islet-related autoantibodies and did not fulfill the criteria for fulminant type 1 diabetes (Fig. 1). In all, 4.7% of fulminant patients and 72.6% of nonfulminant patients (P < 0.0001) were positive for GADAb. The distribution of HbA1c level with or without GADAb at the onset of type 1 diabetes in our hospitals is shown in Fig. 2.
In addition to the 43 patients diagnosed with fulminant diabetes in our hospitals, we also identified 118 patients outside our hospitals with this same diagnosis. In all, we identified 161 patients with fulminant type 1 diabetes.
Regional, seasonal, and chronological changes of incidence.
Fulminant type 1 diabetic patients were reported from all over Japan, from Hokkaido Island to Kyushu Island. Fulminant type 1 diabetic patients were accumulated in crowded areas, but not in a specific region by prefecture in Japan.
The annual number of newly diagnosed patients with fulminant diabetes was 0–7 from 1990 to 2000, and has not increased in our hospitals over the past 10 years. As to seasonal changes, 20 patients were diagnosed with fulminant type 1 diabetes in May, whereas 6–13 patients were diagnosed in the other 11 months. In 2000, 39 cases of newly diagnosed fulminant type 1 diabetes were reported, and the average incidence was 3 cases per month all over Japan. In May and July of 2000, eight and six cases of newly diagnosed fulminant diabetes were reported, respectively; one to four cases were reported monthly in the other 10 months.
In the following analysis, two groups of patients were compared: 161 patients with fulminant type 1 diabetes recruited from studies 1 and 2, and the 137 patients with autoimmune type 1 diabetes recruited from study 1.
Clinical and immunological status at onset.
As shown in Table 1, the mean duration from the onset of hyperglycemic symptoms to the start of insulin therapy was 4.4 days, and the mean value of HbA1c levels, daily urinary C-peptide excretion, and fasting serum C-peptide concentration was 6.4%, 4.3 μg, and 0.3 ng/ml (0.10 nmol/l), respectively, at the onset of fulminant diabetes. The duration of disease was significantly shorter and HbA1c levels, urinary C-peptide excretion, and the serum C-peptide concentration were significantly lower in fulminant than in autoimmune type 1 diabetes.
The mean age at onset of type 1 diabetes was 39.1 years in fulminant type 1 diabetic patients and was significantly older than age at onset in autoimmune type 1 diabetic patients. The age at onset of male fulminant patients was 42.8 ± 14.8 years (mean ± SD) and significantly higher than that of female fulminant patients (35.1 ± 15.8) (P = 0.002). The age at onset of fulminant diabetes ranged from 1 year to 80 years. Childhood/adolescent onset of fulminant diabetes (onset before age 20 years) was seen in 14 patients (3 male and 11 female), whereas adult onset was observed in the remaining 147 patients.
The mean BMI at onset of type 1 diabetes was 20.7 in fulminant type 1 diabetic patients, which was significantly higher than that in autoimmune type 1 diabetic patients. There was no significant difference in the presence of family history of type 1 and type 2 diabetes in first-degree relatives between fulminant and autoimmune diabetes, but autoimmune diseases other than type 1 diabetes were more frequently observed in autoimmune diabetes than in fulminant diabetes (Table 1).
Thirst was the most common symptom accompanying the onset of diabetes and was observed in ∼90% of both fulminant and autoimmune type 1 diabetic patients. Lower body weight loss was observed in fulminant diabetes than in autoimmune diabetes.
Flu-like symptoms, abdominal symptoms, and drowsiness were more frequently observed in the fulminant group than in the autoimmune group at disease onset (P < 0.0001) (Table 1). Among the flu-like symptoms, fever was the most common and was observed in 60.0% of patients. Nausea, vomiting, or both were also frequent and were observed in 65.4% of patients.
Of the 14 patients who had type 1 diabetes during or after pregnancy in this study, 13 belonged to fulminant subtype (Table 1). Their onset was the 19th week in one patient, the 22nd week in one patient, the 26th week in one patient, the 29th week in one patient, the 30th week in three patients, the 31st week in one patient, the 35th week in one patient, the 36th week in two patients, and the 2nd week after delivery in two patients.
Compared to autoimmune type 1 patients, fulminant type 1 patients showed markedly higher plasma glucose concentrations and significantly lower arterial pH at the first visit (Table 1). At least one of three serum exocrine pancreatic enzyme levels—amylase, elastase-1, or lipase—was increased over the normal range in 98 patients. In the fulminant diabetes group, only 2 patients had normal levels of all these enzymes, whereas in the autoimmune diabetes group, 17 patients showed elevated serum levels of at least one of these enzymes and 26 patients showed normal levels of all these enzymes.
As shown in Table 1, fulminant patients had significantly lower serum sodium and chloride levels and significantly higher serum potassium levels than autoimmune patients. Serum ALT and AST levels were significantly higher in the fulminant than in the autoimmune group. Serum triglyceride levels were significantly higher in the fulminant than in the autoimmune patients, but the serum cholesterol level was not significantly different between the two groups.
In the fulminant diabetes group, 4.8% were positive for GADAb, but all were negative for IA-2Ab. Thyroid antimicrosomal antibodies were seen significantly more frequently in autoimmune diabetes than in fulminant diabetes patients (Table 1).
Prognosis.
A patient with fulminant type 1 diabetes died and another patient suffered from cardiac and respiratory arrest at onset. The former patient had been reported previously (16). None of the autoimmune type 1 diabetic patients suffered from such episodes. The other fulminant and autoimmune type 1 diabetes patients survived the metabolic disorder at onset.
Mean HbA1c levels were not significantly different between fulminant and autoimmune type 1 diabetic patients at 3, 6, or 12 months after the onset of overt diabetes. Insulin injection dosages were significantly higher in fulminant than in autoimmune diabetic patients 3, 6, and 12 months after the onset (Fig. 3).
Our present study confirmed 161 cases of fulminant type 1 diabetes distributed all over Japan, and clearly showed that fulminant type 1 diabetes is a distinct subtype within type 1 diabetes judging from the clinical characteristics, such as autoantibody status. Several new findings regarding fulminant type 1 diabetes were also confirmed by this nationwide survey: 1) fulminant diabetes accounted for ∼20% of Japanese type 1 diabetes with ketosis or ketoacidosis at onset; 2) few patients were children or adolescents, and >90% of patients were adults; 3) male patients accounted for ∼50% of all cases; 4) flu-like symptoms, especially fever, were frequently observed at onset; and 5) almost all female patients who developed type 1 diabetes during pregnancy had the fulminant type.
This nationwide survey indicated that fulminant type 1 diabetes is a major subtype in Japan. Several cases similar to fulminant type 1 diabetes have been reported in Japan after (16–23) and even before (8–12) Imagawa et al. proposed this novel subtype. However, few cases have been reported from Western countries (24–27). The number of fulminant type 1 diabetes in Caucasians might be relatively small, and therefore this subtype might have been disregarded among the majority of autoimmune type diabetes cases; however, the fulminant subtype does not appear to be rare, at least in the Japanese population.
Second, >90% of fulminant type 1 diabetic patients were adults and no sex difference was observed among cases. The incidence of type 1 diabetes in Japanese children is 0.8 people/10,000 person-years and lower than the incidence in European countries (28); however, type 1 diabetes is not a rare disease. Nonetheless, few cases of fulminant diabetes were reported in the Japanese children or adolescents in this study. These findings suggested that fulminant type 1 diabetes is most likely an adult-onset disease. Female sex was predominant in autoimmune type diabetes.
Third, flu-like symptoms were significantly more frequent in fulminant type than in autoimmune type diabetes. Fever was the most common among such symptoms. In addition to the markedly acute clinical course at onset, this finding suggests that fulminant diabetes may be associated with viral infection. On the other hand, other frequent symptoms such as nausea, vomiting, and drowsiness could be attributable to severe metabolic acidosis in fulminant diabetes at onset. Another important finding was that fulminant diabetes accompanied pregnancy in 21.0% of females ages 13–49 years, and the incidence clearly increased in the third trimester of pregnancy. This finding was compatible with the fact that the incidence of type 1 was tripled in the third trimester (29).
In addition, the present study also confirmed the basic characteristics of fulminant type 1 diabetes proposed by Imagawa et al. (13): 1) markedly acute onset of diabetes, 2) severe metabolic disorder, and 3) elevated levels of serum pancreatic enzymes. The plasma glucose concentration in fulminant patients was 800 mg/dl, higher than that of autoimmune patients, whereas HbA1c levels of fulminant patients were only slightly higher than the upper limit of normal range. More severe derangement of serum electrolytes was observed in fulminant patients. Loss of consciousness was more frequently observed in fulminant diabetic patients. Lower body weight loss and higher BMI of fulminant patients would indicate shorter duration of hyperglycemic period. The elevation of serum pancreatic enzyme levels was also characteristic of fulminant type 1 diabetes, although these levels can be raised as a consequence of ketoacidosis.
It was also shown that islet-related autoantibodies were seldom positive in fulminant diabetes. In this study, we recruited patients irrespective of the presence or absence of autoantibodies, and it turned out that only 4.8% of fulminant diabetes patients were positive for GADAb and none were positive for ICA and IA-2Ab. Therefore, fulminant type 1 diabetes would be classified as one subtype of idiopathic (type 1B) diabetes, according to the ADA/WHO classification.
Whether or not the pathogenesis of fulminant type 1 diabetes is associated with autoimmunity is still unknown. Tanaka et al. (16) have reported insulitis in an autopsy case of fulminant type 1 diabetes, who died soon after the onset of the disease. Shimada and colleagues reported a fulminant diabetic patient with elevated serum interferon-γ–inducible protein levels (19) and another patient with increased prevalence of GAD-reactive peripheral T-cells (23). These findings suggest that fulminant type 1 diabetes is autoimmune related. However, the prevalence of islet-related autoantibodies in fulminant diabetes was extremely low in the present study. The original report of Imagawa et al. (13) showed neither insulitis nor hyperexpression of MHC class I antigens in islets in all three patients. These findings suggest that fulminant type 1 diabetes is not caused by autoimmunity. Another candidate for the pathogenesis of fulminant diabetes would be viral infection. A frequent flu-like symptom, especially fever at onset in fulminant diabetes, was observed in this study. Two case reports described fulminant diabetes that developed after the reactivation of human herpes virus-6 or the infection of herpes simplex virus (17,22). These findings suggest an association of viral infection to fulminant diabetes.
In conclusion, fulminant type 1 diabetes accounts for ∼20% of the ketosis-onset type 1 diabetic patients in Japan. Flu-like symptoms, especially fever, are characteristic features around the onset of the disease. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The mechanism of β-cell death in fulminant type 1 diabetes should be further investigated, with special attention given to viral infection and autoimmunity. Even a single case report of fulminant type 1 diabetes in other countries would help improve the understanding of this subtype. A worldwide survey should be carried out in the future.
Study design. DM, diabetes.
Distribution of HbA1c at onset of newly diagnosed type 1 diabetes in patients with (□) or without (▪) GADAb. n = number of patients.
Changes in HbA1c levels and insulin injection dosages in fulminant (F) and autoimmune (A) type 1 diabetes during 12 months after the onset. ▪, •, fulminant patients; □, ○, autoimmune patients. P < 0.05 for a vs. b, c, d, and e; b vs. d; e vs. f, g, and h; f vs. g; b′ vs. d′ and f′; c′ vs. d′ and g′; d′ vs. h′; and f′ vs. h′.
Profiles of fulminant and autoimmune type 1 diabetic patients
This study was supported by a grant-in-aid from the Japanese Ministry of Health, Labor, and Welfare, and a grant-in-aid from the Japan Diabetes Society.
We would like to thank the following doctors who referred the patients to our committee: Yoshitaka Aiso, M.D., Aiso Clinic; Keizo Anzai, M.D., and Ikuyo Hayashi, M.D., First Department of Internal Medicine, Fukuoka University School of Medicine; Takahiko Aoki, M.D., Ogaki Municipal Hospital Internal Medicine; Eiichi Araki, M.D., and Tetsushi Toyonaga, M.D., Department of Metabolic Medicine, Kumamoto University School of Medicine; Kaoru Arii, M.D., Kochi Red Cross Hospital; Yoshihito Atsumi, M.D., Satoru Yamada, M.D., and Kempei Matsuoka. M.D., Saiseikai Central Hospital Tokyo; Takuya Awata, M.D., The Fourth Department of Internal Medicine, Saitama Medical School; Yukihiro Bando, M.D., Fukui-ken Saiseikai Hospital; Masahiro Emoto, M.D., and Yoshitomo Oka, M.D., Third Department of Internal Medicine,Yamaguchi University; Hitomi Fujii, M.D., Nakano Kyoritsu Hospital; Tatsuya Haga, M.D., Kainan Hospital of Aichi Prefectural Welfare Federation of Agricultural Cooperatives; Shigeru Haisa, M.D., Department of Internal Medicine, Okayama Municipal Hospital; Mutsumi Hakamata, M.D., Hakamata Medical Clinic; Yoshihito Hara, M.D.; Oume Municipal General Hospital; Naoko Hara-Nakamura, M.D., Internal Medicine, Nippon Telegraph and Telephone West Corporation Matsuyama Hospital; Naotake Hashimoto, M.D., Department of Applied Translational Research, Graduate School of Medicine, Chiba University; Yoshifumi Suzuki, M.D., Kentaro Kaneko, M.D., and Yasushi Saito, M.D., Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University; Tsutomu Hirano, M.D., First Department of Internal Medicine, Showa University School of Medicine; Rieko Honda-Mizuochi, M.D., and Isamu Wada, M.D., Social Insurance Takaoka Hospital; Choung-I-Houng, M.D., Narita Red Cross Hospital; Kayano Igawa, M.D., Mito National Hospital; Yasuo Imai, M.D., Eiji Omura, M.D., and Shoji Kawazu, M.D., First Dept of Internal Medicine, Saitama Medical Center, Saitama Medical School; Mitsuo Imura, M.D., Yaizu Municipal General Hospital of Metabolism and Endocrine Division; Yasushi Inoue, M.D., Department of Internal Medicine, Yamaguchi Prefecture General Hospital; Yukako Inoue-Ozawa, M.D., Internal Catholic Hospital; Harumi Ishidoh, M.D., and Shuhei Hayashi, M.D., Showa General Hospital; Hidehiro Ishii, M.D., and Kayo Morioka, M.D., Kitakyushu Municipal Medical Center, Diabetes Center; Haruhiko Isotani, M.D., Keizo Furukawa, M.D., and Keiichi Kameoka, M.D., Department of Medicine, Hirakata City Hospital; Yasunori Iwashima, M.D., Sano Hospital; Takuyuki Katabami, M.D., Division of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine; Shinkuro Kataoka, M.D. Hiroshima City Asa Hospital; Setsuyo Kawakita, M.D., Toki General Hospital; Masahiro Kawanaka, M.D., Sasayama Branch Hospital of Hyogo Medical College; Junji Kobayashi, M.D., Chibaken Saiseikai Narashino Hospital; Masaki Makino, M.D., Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita Health University School of Medicine; Norio Matsui, M.D., Toyama Kyoritsu Hospital; Akira Matsumoto, M.D., and Masahiro Nomura, M.D., First Department of Internal Medicine, Sapporo-Kosei General Hospital; Nobuo Matsuura, M.D., Department of Pediatrics, Kitasato University School of Medicine; Yoshitaka Miura, M.D., First Department of Internal Medicine, Nagoya University School of Medicine; Umeo Miwa, M.D., Ishikawa Prefectural Central Hospital; Keiko Miya, M.D., Tokushima Red Cross Hospital; Masakazu Mizutani, M.D., Kozawa Eye Hospital and Diabetes Center; Mizue Mogi, M.D., Shiseikai Daini Hospital, Diabetes Department; Takashige Mochizuki, M.D., Nagano Chuo Hospital; Takeshi Momotsu, M.D., and Noriko Tamura, M.D., Second Department of Internal Medicine, Niigata City General Hospital; Mitsuru Moriya, M.D., Department of Internal Medicine, Memuro Municipal Hospital; Seiho Nagafuchi, M.D., First Department of Internal Medicine, Faculty of Medicine, Kyushu University; Shoichiro Nagasaka, M.D., and Ikuyo Kusaka, M.D., Division of Endocrinology and Metabolism, Jichi Medical School; Kunihiko Nakamura, M.D., Department of Internal Medicine Mazda Hospital, Hiroshima; Koji Nakano, M.D., Yamashiro Public Hospital; Kazuyuki Namai, M.D., Omiya Medical Center, Jichi Medical School; Mitsuyoshi Namba, M.D., Division of Diabetes and Metabolism, Department of Internal Medicine, Hyogo College of Medicine; Kishio Nanjo, M.D., and Masahiro Nishi, M.D., First Department of Medicine, Wakayama University of Medical Science; Hiroshi Ninomiya, M.D., Chikushi Hospital, Fukuoka University; Mitsuo Obana, M.D., Department of Internal Medicine, Kawasaki Municipal Hospital; Koji Oida, M.D., Third Department of Internal Medicine, Faculty of Medicine, Fukui Medical University; Midori Okamura, M.D., Kure Kyosai Hospital; Hiromi Ouchi, M.D., Yamauchi Hospital; Ikue Saito, M.D., Saito Clinic; Tsune Sakai, M.D., Sakai Clinic; Shinsuke Sasaki, M.D., Hitachi General Hospital; Wakano Sato, Fukushima Medical University School of Medicine, Department of Internal Medicine III; Hiroaki Seino, M.D., Department of Internal Medicine, Diabetic Center, Ohta Nishinouchi Hospital; Nobuo Sekine, M.D., Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo; Sakae Sekiya, M.D., Juntendo University School of Medicine, Department of General Medicine; Kenji Shima, M.D., Kawashima Hospital; Makiko Shimodahira, M.D., and Hiroyuki Kurahachi, M.D., Department of Endocrinology, Kobe City General Hospital; Junji Shinoda, M.D., Toyota Memorial Hospital, Department of Endocrinology; Masahiro Shinoda, M.D., Inazawa City Hospital; Shingo Shoji, M.D., Department of Endocrinology and Metabolism, Kurume University School of Medicine; Kazuhiko Sugiyama, M.D., Saiseikai Yamagata Saisei Hospital; Seiichi Sumi, M.D., Suita Municipal Hospital; Norihiro Suzuki, M.D., Mizusawa City Hospital; Kenji Takahashi, M.D., Kurashiki Central Hospital; Tatsuro Takano, M.D., and Tadashi Yamakawa, M.D., Department of Endocrinology and Diabetes Mellitus, Yokohama City Medical Center; Akira Takeda, M.D., Matsue Red Cross Hospital; Tsuyoshi Tanaka, M.D., National Mie Chuo Hospital; Kazuyuki Tobe, M.D., Department of Metabolic Diseases, Graduate School of Medicine Tokyo University; Katsuto Tokunaga, M.D., Itami City Hospital; Akira Tsuruoka, M.D., Funabashi Municipal Medical Center; Tatsuhiko Urakami, M.D., Department of Pediatrics, Nihon University School of Medicine; Ryo Uwamizu, M.D., Uwamizu Diabetes Treatment Institute; Takanobu Wakasugi, M.D., Fukui Prefectural Hospital; Nobuaki Watanabe, M.D., Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital; Toshiko Yagi, M.D., Fjieda Municipal General Hospital; Takashi Yamagami, M.D., Ohzu Chuuou Hospital; Kohei Yamaguchi, M.D., Department of Cardiology and Endocrinology, Oita Prefectural Hospital; Takahide Yamaguchi, M.D., Yamaguchi Clinic; Hioryuki Yamamoto, M.D., Tottori Red Cross Hospital; Tsunehiko Yamamoto, M.D., Department of Metabolism and Endocrinology, Osaka City General Hospital; Hiroko Yoneda, M.D., Takeda General Hospital; Yasunao Yoshimasa, M.D., National Cardiovascular Center; Haruhiko Yoshimura, M.D., First Department of Internal Medicine, Hokkaido University Hospital.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
Accepted May 5, 2003.
Received December 12, 2002.
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183–1197, 1997
Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553, 1998
Bottazzo GF, Florin-Christensen A, Doniach D: Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 30:1279–1283, 1974
Eisenbarth GS: Type I diabetes mellitus: a chronic autoimmune disease. N Engl J Med 314:1360–1368, 1986
Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516–542, 1994
Tsuruoka A, Matsuba I, Toyota T, Isshiki G, Nagataki S, Ikeda Y: Antibodies to GAD in Japanese diabetic patients: a multicenter study. Diabetes Res Clin Pract 28:191–199, 1995
Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS: Prediction of type 1 diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926–933, 1996
Wakisaka M, Nunoi K, Wada M, Iwase M, Maki Y, Kikuchi M, Okuda S, Fujishima M: Two cases of abrupt onset type 1 diabetes associated with elevation of elastase 1 and diabetic ketoacidosis. Journal of the Japan Diabetes Society 30:619–624, 1987
Hashimoto N, Makino H, Kanatsuka A, Fujiwara T, Sakurada M, Iwaoka H, Taira M, Osawa K, Yamaguchi T, Yoshida S: A case of insulin-dependent diabetes mellitus with coxsackie B3 virus infection following diaminodiphenyl sulfone (DDS) syndrome. Journal of the Japan Diabetes Society 30:761–765, 1987
Nakanishi K, Kobayashi T, Sugimoto T, Murase T, Itoh T, Kosaka K: Does pan-pancreatic involvement occur in IDDM? (Letter). Diabetes Care 11:100–101, 1988
Kimura N, Fujiya H, Yamaguchi K, Takahashi T, Nagura H: Vanished islets with pancreatitis in acute-onset insulin-dependent diabetes mellitus in an adult. Arch Pathol Lab Med 118:84–88, 1994
Tanaka N, Maruyama T, Iwasaki N, Tanaka S, Matsuzaki M, Hieda H, Suzuki Y: A case of insulin-dependent diabetes mellitus developing after elevation of serum amylase level and low plasma glucose level. Journal of the Japan Diabetes Society 35:121–126, 1992
Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y, for the Osaka IDDM Study Group: A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 342:301–307, 2000
Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y: A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence. Ann Med 32:539–543, 2000
Shimada A, Morirmoto J, Kodama K, Suzuki R, Oikawa Y, Funae O, Kasuga A, Saruta T, Narumi S: Elevated serum IP-10 levels observed in type 1 diabetes. Diabetes Care 24:510–515, 2001
Tanaka S, Kobayashi T, Momotsu T: A novel subtype of type 1 diabetes mellitus. N Engl J Med 342:1835–1837, 2000
Sekine N, Motokura T, Oki T, Umeda Y, Sasaki N, Hayashi M, Sato H, Fujita T, Kaneko T, Asano Y, Kikuchi K: Rapid loss of insulin secretion in a patient with fulminant type 1 diabetes mellitus and carbamazepine hypersensitivity syndrome. JAMA 285:1153–1154, 2001
Shimizu I, Fujii Y, Kohnoue E, Kondou S, Itani O, Takeda H, Hasegawa M, Onuma H, Osawa H, Makino H: Five suspected cases of nonautoimmune fulminant type 1 diabetes mellitus. Journal of the Japan Diabetes Society 44:315–22, 2001
Shimada A, Morimoto J, Kodama K, Oikawa Y, Irie J, Nakagawa Y, Narumi S, Saruta T: T-cell–mediated autoimmunity may be involved in fulminant type 1 diabetes. Diabetes Care 25:635–636, 2002
Sakaue S, Nagata M, Wakabayashi O, Honda T, Yoshimura H, Yamaguchi E, Nishimura M: A case of fulminant type 1 diabetes with elevated rheumatoid factor and the temporal presence of thyroid-stimulating hormone receptor antibody. (Letter). Diabetes Care 25:935–936, 2002
Otsubo M, Shiozawa T, Kimura K, Konishi I: Nonimmune "fulminant" type 1 diabetes presenting with diabetic ketoacidosis during pregnancy. Obstet Gynecol 99(Suppl. 1):877–879, 2002
Nagaoka T, Terada M, Miyakoshi H: Insulin-dependent diabetes mellitus following acute pancreatitis caused by herpes simplex virus: a case report. Journal of the Japan Diabetes Society 44:335–340, 2001
Shimada A, Oikawa Y, Shigihara T, Senda T, Kodama K: A case of fulminant type 1 diabetes with strong evidence of autoimmunity (Letter). Diabetes Care 25:1482–1483, 2002
Pozzilli P, Visalli N, Leslie D, for IMDIAB Group: No evidence of rapid onset (Japanese) type I diabetes in Caucasian patients. Diabetologia 43:1332, 2000
Vreugdenhil GR, Schloot NC, Hoorens A, Rongen C, Pipeleers DG, Melchers WJ, Roep BO, Galama JM: Acute onset of type I diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways. Clin Infect Dis 31:1025–1031, 2000
Pinero-Pilona A, Litonjua P, Aviles-Santa L, Raskin P: Idiopathic type 1 diabetes in Dallas, Texas: a 5-year experience. Diabetes Care 24:1014–1018, 2001
Weets I, Siraux V, Daubresse, J.-C., De Leeuw IH, Fery F, Keymeulen B, Krzentowski G, Letiexhe M, Mathieu C, Nobels F, Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van Der Auwera B, Rui M, De Pauw P, Kaufman L, Gorus FK: Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood. J Clin Endocrinol Metab 87:2597–2605, 2002
Japan IDDM Epidemiology Group: Lack of regional variation in IDDM risk in Japan. Diabetes Care 21:1632–1636, 1998
Buschard K, Buch I, Molsted-Pedersen L, Hougaard P, Kuhl C: Increased incidence of true type I diabetes acquired during pregnancy. Br Med J 294:275–279, 1987
August 2003, 26(8)
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text:
'use strict';

let ActivityFactory = require('./activityFactory');

class Job {
    constructor(json) {
        let info;
        try {
            info = JSON.parse(json);
        } catch (parseError) {
            throw new Error('Cannot create job: invalid json');
        }

        this.name = info.name;
        this.id = info.id;
        this.starter = ActivityFactory.create(info.starter);
        this.activities = {};

        for (let key in info.activities) {
            if (!info.activities.hasOwnProperty(key)) continue;
            let activityDescription = info.activities[key];
            this.activities[key] = ActivityFactory.create(activityDescription)
        }
    }
}

module.exports = Job;


text:
Q: IText Pdf creation from Html fails if HTML contains special/illegal characters Am using itext to create pdf from html content. I build html content in the form of table using java String buffer. A Map contains metadata values of the files in the form of key value pairs. I iterate these key and values to build the html table. The problem is some of the metadata values in map are meaningless/invalid symbols. So pdf creation fails with following exception.
java.io.IOException: Expected > for tag: <{1}/> near line 1, column 717
at com.lowagie.text.xml.simpleparser.SimpleXMLParser.throwException(SimpleXMLParser.java:568)
    at com.lowagie.text.xml.simpleparser.SimpleXMLParser.go(SimpleXMLParser.java:331)
    at com.lowagie.text.xml.simpleparser.SimpleXMLParser.parse(SimpleXMLParser.java:579)
    at com.lowagie.text.html.simpleparser.HTMLWorker.parse(HTMLWorker.java:141)

Content which caused the exception is
"$é6莚ÆuCÅ ©À SÀF;r 1Ì/XQ‡,Ô<ÒÐ"‡(¢ËÄòÅ1¡Ø€ÌÅc

So my question is what are these characters(Non-Ascii,utf-unsupported)? Is there any way to identify and skip them while building html?

A: In real time it is difficult to identify and skip while building HTML
You can use Apache commons-lang to escape HTML
StringEscapeUtils.escapeHtml(""$é6莚ÆuCÅ ©À SÀF;r 1Ì/XQ‡,Ô<ÒÐ"‡(¢ËÄòÅ1¡Ø€ÌÅc")

The output of the above is
“$é6èŽšÆuCÅ ©À SÀF;r 1Ì/XQ‡,Ô<ÒÐ"‡(¢ËÄòÅ1¡Ø€ÌÅc

redpajama_set_name: RedPajamaStackExchange


text:
Q: How to prove that shannon coding is pre-fix free. Here is the definition of shannon coding: https://en.wikipedia.org/wiki/Shannon_coding
I intuitively tried a few distributions and it seemed to work fine. furthermore I tried looking at the relation between the $l_i$ and $p_i$ but seemed to get stuck. Since binary strings of fractions can be defined as $\sum 2^{-k}$, i tried to compare the $p_i$ and see how the binary strings would look like and it seems that these strings only grow in length. Any tips on how to tackle this problem?
Kees

A: I'll give you the idea, so you can formalize it.
Let $m_i = \sum_{k=1}^{i-1} p_i$, the accumulated probabilities.
Let's assume some codeword is, say, $c_i=1010$. We ask ourselves: could it happen that some next codeword $c_j$ with $j>i$ has this $c_i$ as prefix? Say, could it happen that $c_{i+1}=10101....$ ? This could only happen if $m_{i+1}-m_i < 0.0001 = \frac{1}{16}$.
But $m_{i+1}-m_i =p_i$
And we know that, $l_i=4  =\lceil -\log(p_i)\rceil \implies  -\log(p_i) \le 4 \implies  p_i \ge \frac{1}{16}$
Hence that's impossible.


text:
Will StanChart and NTUC's digital bank, Phoenix, be granted the coveted digital banking license in Singapore?
Published August 13, 20206:28 pm
Posted by Chris on August 13, 2020.
Monetary Authority of Singapore (MAS) has resumed the assessment process to award its five coveted digital banking licenses and stated that the winners will be announced in H2 2020. In April 2020, amid the pandemic concerns, the assessment process was put on hold and the 21 applicants were asked to review their business proposals, assumptions, valuations underpinning their financial projections keeping in mind the immediate and post pandemic impact on its business.
With the resumption of the assessment process, MAS announced in June 2020 that it will go ahead with reviewing 14 of the 21 applications stating that "eligible applicants, comprising five digital full bank (DFB) applicants and nine digital wholesale bank (DWB) applicants, will progress to the next stage of assessment", doing so without revealing any names or bid details. This being said, certain applicants – SEA Ltd and Ant Financial and consortiums such as Grab and Singtel, Razer and Sheng Siong Holdings, FWD, LinkSure Global, Insignia Ventures Partners, Carro and iFast Corporation partnering with Hande Group & Yillion Group – have made their bids public.
While acquiring a digital banking license seems pivotal for all these players, most of them come with bare minimum experience of operating a bank. While having relevant experience when venturing into a new business is a stereotypical question, a relevant one is who are these applicants going to service? Singapore with a population of about 5.9 million has an internet penetration of about 88% according to a survey. Also mobile app banking in Singapore stand at about 65%. Considering this, it's hard to think of what value proposition could the 14 applicants bring which differentiates them from other banks? The simple answer to this is to serve the underserved SME sector and workers from unorganized sectors. This digital banking license could foster healthy competition, liberalise banking while being resilient. Companies which want to include financial services as a part of their company portfolio have the chance to use this offering to their advantage.
Another good news for StanChart is that it was recently qualified as a Significantly Rooted Foreign Bank (SRFB) in Singapore. According to the SRFB Framework, the bank can now "establish up to 50 POBs, of which up to 35 may be branches."
While this is true for the known contenders, an unannounced applicant named Phoenix – a consortium of NTUC and Standard Chartered is also in the race for the digital banking license. While contemplating who could head the digital banking initiative in Singapore, TDB perceives co-founders of neobanks such as Judo Bank, Xinja or 86 400 could be credible candidates for this role. For those unaware, Standard Chartered forayed into Africa in 2018 with a digital-only bank in Côte d'Ivoire (CDI) following it up with Uganda, Tanzania, Ghana and Kenya in 2019. Armed with this information, it is obvious why Standard Chartered is entering the race for the digital banking license in Singapore. The bank is well positioned to take advantage of this offering and with success projects in Africa, StanChart is uniquely qualified to come out a winner. Also, one of the key items in the business proposal for the digital banking license application must include regional expansion plans. This would provide the much needed entry point into Southeast Asian markets which hold similar value propositions as Africa.
Another good news for StanChart is that it was recently qualified as a Significantly Rooted Foreign Bank (SRFB) in Singapore. According to the SRFB Framework, the bank can now "establish up to 50 POBs, of which up to 35 may be branches." Not only this MAS is considering enhancements to the framework which will grant "additional full bank licence to an SRFB that substantially exceeds the SRFB baseline criteria. This will enable them (SRFB) to have the same flexibility as Singapore-incorporated banking groups to establish subsidiaries, including with joint-venture partners, to operate new or alternative business models such as a digital-only bank." With all this being said, StanChart seems to be in the right place to use's MAS's proposition.
Image: mimisim / Shutterstock.com
Will the arrival of digital banks shake up Singapore's traditional banking industry?
The Private Wealth Landscape in Mauritius and Bank One's Approach to Wealth Management
Are Big banks set up to 'kill' change? Monzo founder believes so


Researchers have uncovered a unique ability in bats which allows them to carry but remain unaffected by lethal diseases. Unlike humans, bats keep their immune systems switched on 24/7 and scientists believe this could hold the key to protecting people from deadly diseases like Ebola.
Bats are a natural host for more than 100 viruses, some of which are lethal to people, including Middle Eastern Respiratory Syndrome (MERS), Ebola and Hendra virus, but bats do not get sick or show signs of disease from these viruses.
Published today in the journal Proceedings of the National Academy of Sciences (PNAS), this new research examines the genes and immune system of the Australian black flying fox, with surprising results.
"Whenever our body encounters a foreign organism, like bacteria or a virus, a complicated set of immune responses is set in motion, one of which is the defense mechanism known as innate immunity," leading bat immunologist at CSIRO's Geelong-based Australian Animal Health Laboratory Dr Michelle Baker said.
"Interestingly, we have shown that bats only have three interferons, which is only about a quarter of the number of interferons we find in people.
She said unlike people and mice, which activate their immune systems only in response to infection, a bat's interferons are constantly switched on.
"In other mammalian species, having the immune response constantly switched on is dangerous – for example, it's toxic to tissue and cells – whereas the bat immune system operates in harmony.
BACK PAIN – A CULTURAL THING?


including nuclear research materials, and fees are charged for such use.
Supreme Court rules in favor of such activities. A decision is expected to be rendered soon.
Revenue (DOR). A pilot program would be established to collect debt owed to state agencies.
the impact of this proposal.
services were chosen or what the revenue impact might be on an annual basis.
effect date for the increase.


New Super Mario Bros. 2 is a side-scrolling platformer video game in the Super Mario series developed by Nintendo for the Nintendo 3DS handheld console. The game is a direct sequel to the 2006 Nintendo DS game New Super Mario Bros. The game continues the style of gameplay from New Super Mario Bros., featuring side-scrolling platform action as Mario or Luigi attempt to rescue Princess Peach from Bowser and his Koopalings.
New Super Mario Bros. 2 has no graphical issues in Citra. The game by itself runs flawlessly, doesn't require high-end hardware to run this game. You also may notice some slowdowns at times.


text:
Brabus Unveils a Monster, The World's Fastest and Most Powerful Mercedes-Benz E-Class, the 788-bhp, 230-mph E V12 Coupe
By Sam Mitani
Brabus took the veils off of what it's calling the fastest GT in the world, called the E V12 Coupe. Based on the new Mercedes E-Class coupe, the car is powered by the company's SV12 R Biturbo 800 12-cylinder engine that produces 788 bhp and 1047 lb.-ft. of torque. The basis for this engine is the twin-turbo V-12 from the latest Mercedes 600 models. Displacement of the engine is increased from 5.5 to 6.3 liters with the help of a special crankshaft, larger cylinder bore and larger pistons. Both three-valve cylinder heads are optimized for mixture flow, and fitted with sport camshafts. Custom turbochargers and intercoolers as well as a variety of breathing improvements add to the engine's potent nature. Power is transferred to the rear wheels via a reinforced 5-speed automatic transmission and a Brabus high-performance limited-slip differential.
All this allows the revitalized E-Class to run to 100 km/h (62 mph) in just 3.7 seconds, to 200 km/h (124 mph) in 9.9 seconds, and reach 300 km/h (186 mph) after a mere 23.9 seconds. For street-legal use the top speed of the car is limited electronically to 350 km/h (217 mph). Without the limiter the two-door twelve-cylinder car is capable of speeds in excess of 370 km/h (230 mph).
But the most impressive number may be the car's price tag, which comes in at a hefty 478,000 Euros ($650,000) MSRP.
BRABUS SV12 R Biturbo 800 – The World's Most Powerful and Fastest Luxury Sedan
Brabus Unveils World's Fastest Street Legal Sedan at Frankfurt
Brabus Brabus SV12 R Biturbo is the World's Fastest Compact SUV
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text:
Jwala Gutta Biography, Age, Ex-husband, Children, Family, Caste, Wiki & More
Updated On : October 24, 2019
#90 | Most Popular
#27 | Like
7 September, 1983 (Wednesday)
Wardha , Maharashtra
AGE (in 2021)
in centimeters- 178 cm
in meters- 1.78 m
in Feet Inches- 5' 10"
in Kilograms- 60 kg
in Pounds- 132.28 lbs
Jwala Gutta Popularity on Social Media
Jwala Gutta was born on 7th September 1983 in Wardha, Maharashtra. She is an ace Indian Shuttler. She is a recipient of prestigious Arjuna Award for her performance on the court.
Other Professions:
Jwala Gutta Wiki Link
Jwala Gutta Complete Bio & Career
Jwala Gutta is the daughter of Kranti Gutta, a freedom fighter and a leftist from Guntur District, Andhra Pradesh and her mother Yelen Gutta is from China. She started off by playing Tennis but shifted to badminton at the age of 6.
Jwala is an excellent and top-level doubles specialist player from India who has brought laurels to her country. She has won the Nation Badminton Championship 14 times in her illustrious career. Jwala has been representing India for than 15 years now. In Women Doubles she started off by pairing with Shruti Kurien and won the Nationals with her for six consecutive years. She then paired up with another ace shuttler in Ashwini Ponnappa and this pair proved to be the most successful women's doubles pair ever for India.
In mixed doubles, she partnered Valiyaveetil Diju and were the first mix doubles pair from India to win a Grand Prix Gold Title. She and V. Giju entered the quarter finals of most coveted BWF World Championships in 2009 and 2010. In 2009 the pair won Chinese Taipei GP Gold and Indian GP Gold in 2010. She has won Gold, Silver and Bronze medal at the prestigious Common Wealth Games in mixed team and Women doubles events.
Jwala Gutta Popular Videos
AWARD CATEGORY
RECEIPT YEAR
RECEIPT FIELD
Arjuna Award National Sports Award 2011 Badminton
Jwala Gutta Family, Relatives and Other Relations
She was born to Kranti Gutta and Yelan Gutta. She has a sister named Insi Gutta. She married shuttler Chetan Anand in 2005 but the marriage was short-lived and the pair divorced in 2011.
Chetan Anand Ex-husband (2005-2011)
Life's Important Dates Of Jwala Gutta
Breast Size 35
Waist Size 28
Hip Size 36
Body Figure 35-28-36
Skin Colour Fair
Eye Colour Dark Brown
Hair Colour Brown
Home Town Wardha, Maharashtra, India
Address Wardha, Maharashtra, India
Qualification Graduate
Hobbies Driving, Shopping, Travelling
Debut In the 2002 India Asia Satellite Tournament.
Net Worth $10 Million
Best Achievements 14 times winner of National Badminton Championship in doubles
. • Won a bronze at the 2011 BWF World Championships.
• Won a Gold at the 2010 Commonwealth Games.
• Won a silver at the 2014 Commonwealth Games.
• Won a bronze at the 2014 Thomas & Uber Cup.
• Won a bronze at the 2014 Badminton Asia Championships.
Favorite Color Black, White
Favorite Actress Anushka Shetty
Favorite Actor Prabhas
Favorite Film Director Mani Ratnam
Favorite Place Hyderabad, Goa, Dubai
Favorite Food Chaat, Chinese Cuisines
Shocking / Interesting Facts & Secrets About Jwala Gutta
She wanted to proceed her career in "Tennis" but her mother insisted on her to play "Badminton".
Before starting her training for Badminton she first started to learn Swimming and Gymnastics.
In 2011, she was conferred by Arjuna Award (India's 2nd highest She on) by the Govt Of India.
In 2013, she appeared in an item number in a film 'Gunde Jaari Gallanthayyinde' (Telugu).
At the age of 4, she had introduced her with the National Badminton Coach, S. M. Arif by her father.
In the year 2010, she paired up with partner Ponnappa, first time and the duo won the gold medal for their spectacular performance. This was the first gold for India won in that event.
At the age of 6 she won the "Under-13 Girls Mini National Badminton Championship" held in Kerala.
Jwala Gutta Age, Birthday Facts and Birthday Countdown
37 years, 4 months, 10 days old age Jwala Gutta will turn 38 on 07 September, 2021. Only 7 months, 20 days, 18 hours, 57 minutes has left for her next birthday.
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Jwala Gutta has celebrated the total number of 37 birthdays till date. See the analysis by days count and bar graph.
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