How will antiphospholipid sydrome affect me?
Antiphospholipid syndrome (APS) is sometimes known as 'sticky blood syndrome' or Hughes syndrome. APS can cause blood clotting in your arteries or veins and is a major cause of recurrent miscarriage. It's also one of the most common causes of strokes in young people. It's estimated that 1 in 5 people who've had a stroke before the age of 40 may have APS.
APS affects all age groups but is most common between the ages of 20 and 50. It was first diagnosed in people who had lupus (systemic lupus erythematosus) but it was later discovered that APS can occur on its own (this is called primary APS).
The two main problems caused by antiphospholipid syndrome (APS) are blood clotting (thrombosis) and pregnancy problems, particularly recurrent miscarriage.
the brain, which can cause memory loss, migraines, forgetfulness, slurred speech, fits or sight problems.
In pregnancy, APS can cause recurrent miscarriage. This can happen at any time during your pregnancy but is most common between 3 and 6 months. APS can also cause other pregnancy problems, such as high blood pressure (pre-eclampsia), small babies and early deliveries. APS is now recognised as one of the most important treatable causes of recurrent miscarriages.
Heart problems – The heart valves may thicken and fail to work, or your arteries may narrow because their walls get thicker, leading to angina.
Kidney problems – APS can cause narrowing of the blood vessels, resulting in high blood pressure.
Infertility – Testing for antiphospholipid antibodies (aPL) is becoming routine in infertility clinics.
Skin problems – Some people develop a blotchy rash, often seen on the knees or arms and wrists, with a lacy pattern (known as livedo reticularis).
Low platelet count – Some people with APS have very low platelet levels – often there are no symptoms, although people with very low counts may bruise easily or experience strange or excessive bleeding.
Very rarely, APS can cause clots to develop in small blood vessels in several parts of your body at once, causing damage to several organs at the same time and making you seriously ill. This is called catastrophic APS and is very rare. It's thought to be triggered by things like infection, trauma, medication or surgery. You should have quick and easy access to your rheumatology or haematology team in these circumstances.
Antiphospholipid syndrome (APS) is an autoimmune disease, which means that it's caused by your immune system attacking healthy parts of the body instead of fighting infections.
If you have APS, your immune system produces harmful antibodies called antiphospholipid antibodies (aPL) which attack proteins are linked to fats in your body. The most important of these proteins is called beta-2-glycoprotein I. When aPL stick to this protein they can interfere with blood cells. The cells change in such a way that the blood becomes sticky and more likely to clot inside the vessels. In a pregnant woman aPL can also affect the cells of the womb and the placenta, which can make the baby grow more slowly and increase the risk of miscarriage.
genetic factors – there may be a family history of clots, miscarriages, other autoimmune diseases such as lupus or thyroid problems.
Many people with APS feel very well and have no symptoms. The aim of treatment is to prevent thrombosis or miscarriage. This is achieved by an early diagnosis and the right combination of drugs. Other people with APS have symptoms like rash, joint pain, migraine and tiredness even when they don't suffer thrombosis and are not pregnant. This is especially true in people who have lupus as well as APS.
Because the drugs are used to prevent symptoms, it means you may be taking drugs for many years even though you have no symptoms. As with all drugs there can be side-effects, so it's important to balance the risk of side-effects against the risks of condition itself. With the right approach the outlook for most people with APS is good.
you've suffered either thrombosis or miscarriage.
More and more people who have thrombosis or a miscarriage are routinely tested for APS. If you've had either of these problems, especially if they've happened more than once, you should discuss with your doctor whether you need these blood tests. Depending on the results, your doctor may want to refer you to a specialist (either a rheumatologist or haematologist).
All three tests detect whether aPL are present in the blood. The result of the lupus anticoagulant test is either positive or negative, while the results of the other two tests are given as numbers. The higher this number is, the more aPL a person has in their blood. Because these tests measure aPL in different ways, around 20% of people with APS will have a negative result in one test or the other. One test alone could therefore miss the diagnosis.
The tests are usually repeated after 12 weeks as levels of aPL vary and can sometimes go up when you have an infection. If you only have one positive test and it quickly becomes negative again then you probably don't have APS.
Higher levels of antibodies (i.e. higher numbers in the anticardiolipin or anti-beta-2-glycoprotein I tests) suggest you may be at greater risk of blood clots and other symptoms. Being positive in more than one of the three tests also suggests a higher risk.
I repeatedly test positive for aPL. Does this mean I'll definitely get APS?
No, it doesn't mean that you'll definitely develop APS. Many people who have lupus are tested for these antibodies and about 20–30% will be positive for aPL. People who carry the antibodies but who've never had either clots or miscarriages aren't said to have APS but to be aPL-positive.
whether you have other typical symptoms (such as migraine).
Am I being tested for lupus?
No, this confusion often arises because one of the blood tests for APS is called the "lupus anticoagulant" test. This is because it was first invented by doctors who were studying patients with lupus. In fact it is a test for APS, NOT a test for lupus. There are other, better blood tests for lupus itself and many people who are positive in the "lupus anticoagulant" test do not have lupus.
Antiphospholipid syndrome (APS) can't be cured but the effects can be controlled. Treatment with anticoagulant (blood-thinning) drugs can help prevent both blood clots and miscarriages. The most commonly used drugs are aspirin, warfarin and heparin.
If you have aPL but no history of clotting, your doctor will probably recommend low daily dose aspirin (75–100 mg). This isn't guaranteed to prevent blood clots but is known to make the blood less sticky. If you have other factors which increase your risk of clots, or if you suffer from typical APS symptoms such as migraine or livedo reticularis, your specialist may advise you to take warfarin instead of aspirin.
If you have APS and a history of clotting, you're likely to be given warfarin to prevent further blood clots. Warfarin is taken by mouth. You'll have regular blood tests (called an INR, or International Normalised Ratio) to check what effect the drug is having, and if necessary your dose will be adjusted. The INR blood tests can be just a finger-prick test or a sample of blood may be sent off for assessment by a laboratory. The most serious side-effect of warfarin during treatment is bleeding. This means that your dosage will be closely monitored.
Warfarin can interact with a number of drugs and foods (for example grapefruit juice), so it's important that you're aware of this and take steps to ensure your other medications or diet won't affect the results of the blood tests.
treatment outside pregnancy to prevent clots.
During pregnancy the usual treatment is low-dose aspirin; however, it's common for pregnant women with APS to be given daily injections of heparin as well as aspirin, especially if the previous miscarriages happened in mid- to late pregnancy or if there have been other pregnancy complications such as pre-eclampsia.
It's a good idea to be seen in a special pregnancy clinic where the doctors have experience of APS, as well as by your normal obstetrician. Most APS specialists have access to those clinics and you should ask about this if you're planning to have a baby.
If you're on warfarin and you become pregnant you'll probably be changed over to heparin. This is because warfarin is potentially harmful to the baby.
Learn how you can manage the symptoms of antiphospholipid syndrome.
Although there aren't any specific exercises that can help with the condition, taking regular exercise will help keep you fit and keep your heart healthy.
It's been suggested that increasing the amount of essential fatty acids in your diet, particularly omega-3 fatty acids found in oily fish, could help reduce your risk of blood clots. However, there are no clinical trials to support this idea. As well as this, fish oils contain large amounts of vitamin A which can be harmful in pregnancy, so we wouldn't recommend this if you're thinking of having a baby. Eating a healthy, balanced diet is important for your general health and may help prevent you from developing blood clots. You should also keep to a healthy weight and stop smoking.
At present, no complementary therapies have been shown to help with APS.
Don't smoke – smoking will increase your risk of clots.
Don't drink excessive amounts of alcohol.
Think very carefully about what sort of contraception to use and discuss it with your doctor, as some types of contraceptive pill increase the risk of clotting.
If you're thinking about hormone replacement therapy after the menopause, this may also increase your risk of clots so you should discuss it with your doctor.
Think ahead if you know you'll soon have to keep still in one place for a long time (for example on a long-haul flight) and see if you can take measures to avoid this (e.g. booking a seat with legroom or buying flight socks).
If you have another condition that can increase your risk of blood clots (e.g. diabetes, high blood pressure or high cholesterol) you should make sure you have regular checks to keep these factors under control.
It's important that you understand the features of APS and therefore when to ask for help. You should have access to your local specialist team, which may include a specialist nurse who you can call for advice.
If you're taking drugs such as warfarin you should be careful about accidents, as bruising can be worse. If you're pregnant it's important that you attend your clinic appointments and keep in touch with your specialist obstetric consultant, whose aim is always to keep you and your baby healthy.


text:
Q: React native material ripple typescript error when using children I have joined the project where react native material ripple is in use,
 "react-native-material-ripple": "^0.9.1",
 "@types/react-native-material-ripple": "^0.9.2",

And there are typescript errors all over the place saying that
 Overload 1 of 2, '(props: RippleProps | Readonly<RippleProps>): Ripple', gave the following error.
    Type '{ children: Element; onPress: () => void; style: { height: number; width: number; margin: number; borderRadius: number; overflow: "hidden"; alignItems: "center"; justifyContent: "center"; }; }' is not assignable to type 'IntrinsicAttributes & IntrinsicClassAttributes<Ripple> & Readonly<RippleProps>'.
      Property 'children' does not exist on type 'IntrinsicAttributes & IntrinsicClassAttributes<Ripple> & Readonly<RippleProps>'.
  Overload 2 of 2, '(props: RippleProps, context: any): Ripple', gave the following error.
    Type '{ children: Element; onPress: () => void; style: { height: number; width: number; margin: number; borderRadius: number; overflow: "hidden"; alignItems: "center"; justifyContent: "center"; }; }' is not assignable to type 'IntrinsicAttributes & IntrinsicClassAttributes<Ripple> & Readonly<RippleProps>'.
      Property 'children' does not exist on type 'IntrinsicAttributes & IntrinsicClassAttributes<Ripple> & Readonly<RippleProps>'.ts(2769)

I have checked the documentation and in the example, on GitHub it clearly says that is should contain children https://github.com/n4kz/react-native-material-ripple#usage
would you be able to tell me what can I do to get rid of these errors? It gives a very negative impression that there are errors in every file and a feeling of code being untidy.
Thanks

redpajama_set_name: RedPajamaStackExchange


Thank you for visiting the online home of National Orthodontics. Our site strives to provide valuable information about our practice that will help you become familiar with orthodontics. Our office is strongly committed to providing you with the highest quality of care. We will make every effort to ensure that your first visit with us is pleasurable and informative.
Orthodontic problems require specialized care. Patients who have dental and facial irregularities should see an orthodontist. Our specific qualifications in the design, application and control of corrective appliances will bring teeth, lips, and jaws into proper alignment for optimal facial balance.
The doctors and technicians of National Orthodontics have the knowledge, specialized equipment, facilities, and staff to handle all of your family's orthodontic needs. Our qualified staff of consultants will hand walk you through the entire process.Please feel free to email or call us with any questions.
The mission of National Orthodontics is to perfect the smiles of our patients. We strive to provide the highest quality state-of-the-art orthodontic therapy in a professional environment. The restoration of beauty and function is a way to increase self esteem, confidence and the way one is perceived, and will increase overall health and wellness.
Dr. J. Jason Thomas was born and raised in Lansing, Michigan. In 1992 he decided to forego plans of attending art school, opting instead to attend Alcorn State University to pursue a degree in Biological Sciences. While at Alcorn he walked onto the football team, pledged into the Alpha Phi Alpha fraternity and graduated with honors in 1995. In 1996 he was accepted to the Howard University College of Dentistry. As a sophomore, Dr. Thomas met the then dental school dean Dr. Charles F. Sanders who has since been his friend and mentor. That summer he began his orthodontic apprenticeship under the tutelage of Dr. Sanders in his Silver Spring, Maryland office.
Top Orthodontist in Camp Creek, East Point, Atlanta, Lithonia, Decatur, Stockbridge, McDonough, Lilburn, Stone Mountain, Stonecrest, Norcross, Fairburn, Morrow, Forest Park, Georgia (GA). Affordable Braces for children, teens, and adults.
I was just abouut to get my braces put on at another office when my co-worker stopped me and told me about an office that's open satudays and evenings! I though it was either too good to be true or would cost me an arm and a leg. It was neither. I've been in my braces for 7 months now and although my treatment isn't complete, I get compliments on my new smile daily!
They were super and wonderful at the same time. My braces needed to be adjusted and the Dr was very gentle.


text:
The best Lesbian films on Netflix
Published on : 3rd September 2020 3rd September 2020 by Newsdesk
All the lesbian films available to stream on Netflix.
Netflix has quite a good number of films where, lesbian, bi and curious women are at the heart of the story. Here's some of the best available to stream.
Good Kisser
A powerful and heart-wrenching tale of finding love in the least likely of places. Academy Award nominee Ellen Page (Inception, The Umbrella Academy) and Kate Mara (House of Cards) star in the highly compelling and moving romantic drama, My Days of Mercy. Two young women from opposite sides of fierce protests over the death penalty meet on the picket lines and form an unlikely friendship. While both deal with their respective personal issues they grow ever closer, leading to dramatic personal revelations, passion and life-changing romance.
Elisa & Marcela
A forbidden love story, based on true events. In 1901, set in Galicia, Spain, Elisa Sánchez Loriga adopted a male identity to marry another woman, Marcela Gracia Ibeas, making this the first same-sex marriage in Spain.
Andi (Constance Wu) and Lu (Angela Trimbur) are excited to celebrate their upcoming wedding with a joint bachelorette weekend in wine country. On the first night, things go awry when one of the brides admits she's never had an orgasm
Are your temptations too intoxicating to resist? The cast and creators of Netflix Original Series Gypsy discuss Jean's perfect life, Diane's deception and her weakness for her desires. Gypsy is now streaming, only on Netflix.
The Miseducation on Cameron Post
After being caught with another girl in the back seat of a car on prom night, Cameron is shipped off to a conversion therapy centre that treats teens. This is her story going against the grain and trusting her inner voice.
Duck Butter
Dissatisfied with the dishonesty they see in dating, strangers Naima (Alia Shawkat) and Sergio (Laia Costa) make a pact to spend 24 straight hours together in an attempt to fast forward their relationship.
It's time to face the music. Watch The Perfection only on Netflix on May 24, 2019. A troubled musical prodigy (Allison Williams) seeks out the new star pupil of her former school (Logan Browning) with shocking consequences in this elegant and terrifying suspense ride, the most buzzed-about movie at last year's Fantastic Fest.
Shy, straight-A student Ellie is hired by sweet but inarticulate jock Paul, who needs help winning over a popular girl. But their new and unlikely friendship gets complicated when Ellie discovers she has feelings for the same girl. From Writer/Director Alice Wu.
Un Freedom
Unfreedom is an indie film which is unique and very different from main stream Indian cinema. As banned in India this film is scheduled to release in various cities of North America on 29th of May, 2015. Directed and written by Raj Amit Kumar this film shows two parallel stories about religious fundamentalism and intolerance; shifting between New York and New Delhi the film Unfreedom is absolutely thought provoking.
A Secret Love
Amid shifting times, two women kept their decades-long love a secret. But coming out later in life comes with its own set of challenges.
What Keeps You Alive
On the eve of their one-year wedding anniversary, Jules and Jackie become embroiled in a merciless fight for their lives when they find themselves pitted against the most unexpected of adversaries: each other. As violence rains down upon their idyllic forest getaway, the women engage in a frenzied psychological and vicious battle that will test the very limits of their instinct to survive. From the mind of Colin Minihan, director of GRAVE ENCOUNTERS and IT STAINS THE SANDS RED, WHAT KEEPS YOU ALIVE is a knife to the throat of 21st century genre cinema.
The Tree Of Blood
Jewel's Catch One
Jewel's Catch One's documents the oldest Black owned disco in America and establishes the legacy of businesswoman, activist, and healer, Jewel Thais-Williams, who stood up against hate and discrimination for 42 years. The story of Jewel and "The Catch" celebrates four decades of music, fashion, celebrity, and activism that helped change the course of our country by breaking down racial, social, and cultural barriers. One of the original safe spaces for both the LGBT and Black communities, The Catch also served as a refuge for many during the AIDS crisis. As her club grew to become known as the "unofficial Studio 54 of the West Coast," Jewel became a national model for how to discrimination and serve the less fortunate.
Jenny, a musical prodigy, finds herself behind bars for murder, but one person wants to help her out — Traude, the 80-year-old piano instructor who has taught at the prison for years. Traude plans to enter Jenny in a prestigious competition, but will the headstrong Jenny waste her one chance for redemption?
When a snowstorm hits a small town on Christmas Eve, a group of high school seniors finds their friendships and love lives unexpectedly colliding.
Other Genres: BIOPICS | CRIME | COMEDY | DRAG | DRAMA | DOCUMENTARY | LESBIAN | ROMANTIC | TRANS | SPORTS | ALL LGBT FILMS ON NETFLIX
The news team for THEGAYUK. Got tips? Go to www.thegayuk.com/newsdesk to tell us something.
FilmLesbian Films On Netflix, LGBT Streaming Lists, Netflix
Previous Previous post: All the transgender movies available to stream on Netflix
Next Next post: Best Drag Queen content on Netflix

redpajama_set_name: RedPajamaCommonCrawl


text:
package edu.harvard.we99.domain;

import javax.annotation.Generated;
import javax.persistence.Embeddable;

/**
 * @author alan orcharton
 */
@Embeddable
public class FitParameter {

    private Double value;

    private String name;

    private ParameterStatus status = ParameterStatus.FLOAT;

    public FitParameter(){}

    public FitParameter(String name, double value, ParameterStatus status){
        this.name = name;
        this.value = value;
        this.status = status;
    }

    @Generated("generated by IDE")
    public Double getValue() {
        return value;
    }

    @Generated("generated by IDE")
    public FitParameter setValue(Double value) {
        this.value = value;
        return this;
    }

    @Generated("generated by IDE")
    public String getName() {
        return name;
    }

    @Generated("generated by IDE")
    public FitParameter setName(String name) {
        this.name = name;
        return this;
    }

    @Generated("generated by IDE")
    public ParameterStatus getStatus() {
        return status;
    }

    @Generated("generated by IDE")
    public FitParameter setStatus(ParameterStatus status) {
        this.status = status;
        return this;
    }
}

redpajama_set_name: RedPajamaGithub