text:
Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus
Daniel Castillo, Sonia Puig, Mar Iglesias, Agustín Seoane, Carme de Bolós, Vicente Munitiz, Pascual Parrilla, Laura Comerma, Richard Poulsom, Kausilia K. Krishnadath, Luís Grande, Manuel Pera
Background: A human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett's esophagus. Methods: Biopsies of the remnant esophagus from 18 patients undergoing esophagectomy with gastric preservation were taken at 6-36-month intervals postoperatively and examined for activation of the BMP pathway (BMP4/P-Smad 1/5/8) and CDX2 and CDX1 expression by imunohistochemistry, quantitative real-time PCR, Western blot, and in situ hybridization. Results: A short segment (mean 15. 6 mm) of NSCM was detected in 10 (56%) patients, with an increasing prevalence from 17% at 6 months to 62% at 36 months. Nuclear expression of P-Smad 1/5/8 in the squamous epithelium close to the anastomosis with strong expression in all epithelial cells of NSCM areas was found. Forty-eight (63%) biopsies with NSCM showed scattered nuclear expression of CDX2. Two cases showed isolated glands at 18, 24, and 36 months that fully expressed CDX2 and co-expressed CDX1. BMP4 mRNA and CDX2 mRNA levels were significantly greater in NSCM than in squamous epithelium. Conclusions: BMP4 activation in NSCM and early expression of CDX2 are involved in the columnar epithelial differentiation of Barrett's esophagus. © 2011 The Society for Surgery of the Alimentary Tract.
Journal of Gastrointestinal Surgery
CDX1
Columnar metaplasia
Dive into the research topics of 'Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus'. Together they form a unique fingerprint.
Barrett Esophagus Medicine & Life Sciences 100%
Metaplasia Medicine & Life Sciences 90%
Epithelium Medicine & Life Sciences 21%
Biopsy Medicine & Life Sciences 16%
Esophagectomy Medicine & Life Sciences 16%
Messenger RNA Medicine & Life Sciences 15%
Gastroesophageal Reflux Medicine & Life Sciences 14%
Esophagus Medicine & Life Sciences 12%
Castillo, D., Puig, S., Iglesias, M., Seoane, A., de Bolós, C., Munitiz, V., Parrilla, P., Comerma, L., Poulsom, R., Krishnadath, K. K., Grande, L., & Pera, M. (2012). Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus. Journal of Gastrointestinal Surgery, 16(2), 227-237. https://doi.org/10.1007/s11605-011-1758-5
Castillo, Daniel ; Puig, Sonia ; Iglesias, Mar ; Seoane, Agustín ; de Bolós, Carme ; Munitiz, Vicente ; Parrilla, Pascual ; Comerma, Laura ; Poulsom, Richard ; Krishnadath, Kausilia K. ; Grande, Luís ; Pera, Manuel. / Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus. In: Journal of Gastrointestinal Surgery. 2012 ; Vol. 16, No. 2. pp. 227-237.
@article{bc0c5e3fcb8b4b139b2fe12c0a3e6399,
title = "Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus",
abstract = "Background: A human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett's esophagus. Methods: Biopsies of the remnant esophagus from 18 patients undergoing esophagectomy with gastric preservation were taken at 6-36-month intervals postoperatively and examined for activation of the BMP pathway (BMP4/P-Smad 1/5/8) and CDX2 and CDX1 expression by imunohistochemistry, quantitative real-time PCR, Western blot, and in situ hybridization. Results: A short segment (mean 15. 6 mm) of NSCM was detected in 10 (56%) patients, with an increasing prevalence from 17% at 6 months to 62% at 36 months. Nuclear expression of P-Smad 1/5/8 in the squamous epithelium close to the anastomosis with strong expression in all epithelial cells of NSCM areas was found. Forty-eight (63%) biopsies with NSCM showed scattered nuclear expression of CDX2. Two cases showed isolated glands at 18, 24, and 36 months that fully expressed CDX2 and co-expressed CDX1. BMP4 mRNA and CDX2 mRNA levels were significantly greater in NSCM than in squamous epithelium. Conclusions: BMP4 activation in NSCM and early expression of CDX2 are involved in the columnar epithelial differentiation of Barrett's esophagus. {\textcopyright} 2011 The Society for Surgery of the Alimentary Tract.",
keywords = "Barrett's esophagus, BMP4, CDX1, CDX2, Columnar metaplasia",
author = "Daniel Castillo and Sonia Puig and Mar Iglesias and Agust{\'i}n Seoane and {de Bol{\'o}s}, Carme and Vicente Munitiz and Pascual Parrilla and Laura Comerma and Richard Poulsom and Krishnadath, {Kausilia K.} and Lu{\'i}s Grande and Manuel Pera",
journal = "Journal of Gastrointestinal Surgery",
publisher = "Springer New York",
Castillo, D, Puig, S, Iglesias, M, Seoane, A, de Bolós, C, Munitiz, V, Parrilla, P, Comerma, L, Poulsom, R, Krishnadath, KK, Grande, L & Pera, M 2012, 'Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus', Journal of Gastrointestinal Surgery, vol. 16, no. 2, pp. 227-237. https://doi.org/10.1007/s11605-011-1758-5
Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus. / Castillo, Daniel; Puig, Sonia; Iglesias, Mar; Seoane, Agustín; de Bolós, Carme; Munitiz, Vicente; Parrilla, Pascual; Comerma, Laura; Poulsom, Richard; Krishnadath, Kausilia K.; Grande, Luís; Pera, Manuel.
In: Journal of Gastrointestinal Surgery, Vol. 16, No. 2, 01.02.2012, p. 227-237.
T1 - Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus
AU - Castillo, Daniel
AU - Puig, Sonia
AU - Iglesias, Mar
AU - Seoane, Agustín
AU - de Bolós, Carme
AU - Munitiz, Vicente
AU - Parrilla, Pascual
AU - Comerma, Laura
AU - Poulsom, Richard
AU - Krishnadath, Kausilia K.
AU - Grande, Luís
AU - Pera, Manuel
N2 - Background: A human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett's esophagus. Methods: Biopsies of the remnant esophagus from 18 patients undergoing esophagectomy with gastric preservation were taken at 6-36-month intervals postoperatively and examined for activation of the BMP pathway (BMP4/P-Smad 1/5/8) and CDX2 and CDX1 expression by imunohistochemistry, quantitative real-time PCR, Western blot, and in situ hybridization. Results: A short segment (mean 15. 6 mm) of NSCM was detected in 10 (56%) patients, with an increasing prevalence from 17% at 6 months to 62% at 36 months. Nuclear expression of P-Smad 1/5/8 in the squamous epithelium close to the anastomosis with strong expression in all epithelial cells of NSCM areas was found. Forty-eight (63%) biopsies with NSCM showed scattered nuclear expression of CDX2. Two cases showed isolated glands at 18, 24, and 36 months that fully expressed CDX2 and co-expressed CDX1. BMP4 mRNA and CDX2 mRNA levels were significantly greater in NSCM than in squamous epithelium. Conclusions: BMP4 activation in NSCM and early expression of CDX2 are involved in the columnar epithelial differentiation of Barrett's esophagus. © 2011 The Society for Surgery of the Alimentary Tract.
AB - Background: A human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett's esophagus. Methods: Biopsies of the remnant esophagus from 18 patients undergoing esophagectomy with gastric preservation were taken at 6-36-month intervals postoperatively and examined for activation of the BMP pathway (BMP4/P-Smad 1/5/8) and CDX2 and CDX1 expression by imunohistochemistry, quantitative real-time PCR, Western blot, and in situ hybridization. Results: A short segment (mean 15. 6 mm) of NSCM was detected in 10 (56%) patients, with an increasing prevalence from 17% at 6 months to 62% at 36 months. Nuclear expression of P-Smad 1/5/8 in the squamous epithelium close to the anastomosis with strong expression in all epithelial cells of NSCM areas was found. Forty-eight (63%) biopsies with NSCM showed scattered nuclear expression of CDX2. Two cases showed isolated glands at 18, 24, and 36 months that fully expressed CDX2 and co-expressed CDX1. BMP4 mRNA and CDX2 mRNA levels were significantly greater in NSCM than in squamous epithelium. Conclusions: BMP4 activation in NSCM and early expression of CDX2 are involved in the columnar epithelial differentiation of Barrett's esophagus. © 2011 The Society for Surgery of the Alimentary Tract.
KW - Barrett's esophagus
KW - BMP4
KW - CDX1
KW - Columnar metaplasia
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
Castillo D, Puig S, Iglesias M, Seoane A, de Bolós C, Munitiz V et al. Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus. Journal of Gastrointestinal Surgery. 2012 Feb 1;16(2):227-237. https://doi.org/10.1007/s11605-011-1758-5


A quick intro; My name is Tim and I'm the owner of UNION.
Some of your guests are coming from out of town to spend the weekend with you. They are traveling anyway, so why not make it a mini, or even extended, vacation for them? Even your local guests are usually excited about the "opportunity" to make it a stay-cation.
Finally, don't count on your guest count shrinking because it's a destination for them. Count on people showing up and being stoked you got them out of work a day early with a chance to spend the weekend with you and your loved ones!


Q. Where can I find information on consumer debt?
"Consumer debt" has many different components. Here are some options depending on whether or not you need information on overall debt, or a part of it.
* Section 25. Banking, Finance, and Insurance (PDF) - search for keyword "debt"


23 IMF Book Forum, Anirvan Banerji, Beating the Business Cycle: Can Turning Points in the Economy be Predicted? Washington, D.C.
13-14 IMF seminar for legislators on value-added tax policy and administration, Lao P.D.R.
8 IMF Economic Forum, "IMF Conditionality: Good, Bad, or Ugly?" Washington, D.C.
19 IMF Book Forum, Rietra Rivoli, Travels of a T-shirt in the Global Economy: An Economist Examines the Markets, Power, and Politics of World Trade, Washington, D.C.
3-4 IMF Jacques Rolak Sixth Annual Research Conference, Washington, D.C.
For an up-to-date listing of IMF Executive Board meetings, see http://www.imf.org external/np/sec/bc/eng/index.asp.


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Emerson College Los Angeles held its first-ever Transition Week March 23–28, providing graduating seniors a series of workshops and industry visits to help prepare them for life after college.
"We want to plant seeds in their minds to start planning now…so they can be set up for success," said Rob Eckard '10, residence director for student programming at Emerson Los Angeles.
The week kicked off with a relaxation workshop to help students de-stress through arts therapy and a massage program. Students also attended a taping of Whose Line Is It Anyway?, where they met with a producer's assistant—a job some might consider in the near future.
· Discussion panel on selling your internship experience with SEO specialist Max Goldberg '07; Lionsgate human resources coordinator Amanda Maltz '10; and Ross Leitner, an internship site supervisor for a local production company.
Emerson's Career Services Office was also on hand during the week to meet with students individually.
Enrique Rivera '15, a Visual and Media Arts major, participated in the workshop.


text:
Opinion: Cross-Play Could Make The Platform Wars Fun
Pitting Xbox vs PlayStation vs PC vs Switch players could turn bickering into a fun team rivalry.
By Dan Stapleton
Updated: 6 Aug 2020 3:57 pm
Posted: 11 Oct 2019 10:52 pm
As we approach the launch of a new round of consoles from Microsoft and Sony in holiday 2020, those of us who enjoy discussing the hobby of video games are all bracing for the inevitable, corresponding rise in online chest-thumping and trolling from die-hard devotees of both companies. But this time around, things can be different: thanks to the long-overdue arrival of cross-play between PlayStation, Xbox, PC, and Switch players in certain games, there's a real opportunity to channel that mean-spirited Console Warrior energy into something good and fun for everybody.
Imagine Microsoft, Sony, and Nintendo actively rallying their fans to play, say, Rocket League or Fortnite during the following week and opt into platform-based matchmaking so they can wave the flag for their teams by scoring victories in a given game mode. (PC gamers don't have a corporate overlord, but have never been shy about showing up to an opportunity to demonstrate superiority.) Or, in the forthcoming Call of Duty: Modern Warfare, it could be the Blue Team vs the Green Team, with PlayStation and Xbox logos emblazoned on their military fatigues. Who will win? How will the platform owners reward the winners and incentivize the losers to fight harder next time? Is hiring pro gamers to turn the tide of battle off-limits? We'd find out!
This could let overzealous fans advocate for their gaming hardware of choice with awesome and intense in-game actions instead of petty bickering, slap-fighting, and trolling in comment sections. Whenever we see people calling each other "Xbots" or "Ponies" over resolution and frame rate differences, we can tell them to stop wasting everybody's time and settle it on the battlefield.
Tell platform warriors to stop bickering and settle it on the battlefield.
Just like that, a nasty exchange of insults turns into an in-game rivalry where everybody's having fun instead of getting angry. I mean, I'm sure there'd still be insults, but that's pretty standard for online multiplayer gaming. Turning the competition between platforms from a blood feud into something more like joining a sports team would be a big improvement.
Have you played Call of Duty: Modern Warfare?
Would PC players have an advantage in any such battle in games where precise aiming matters? Absolutely. But when you know the playing field isn't level you can tilt it in other ways, like limiting the PC side to have fewer players or adjusting the matchmaking to pair higher-rated console players against weaker mouse and keyboard teams. It just takes a little imagination and putting your thumb on the scale in the right way to make a lopsided battle fun for everybody.
Arguably, dividing players by platform is contrary to the unifying spirit of cross-play, where everyone is at last swimming in the same community pool. But as long as there are multiple gaming devices to choose from there will be sides to pick and clubs within that larger online group, and friendly competition between them is the kind of good-natured platform war I can actually get behind.
Dan Stapleton is IGN's Reviews Editor. You can follow him on Twitter for a steady stream of grammar rants, dumb jokes, and nerdy gaming takes.
Developed by Infinity Ward, Call of Duty: Modern Warfare puts you in the role of highly-skilled Tier One operators in an incredibly raw and gritty narrative affecting the global balance of power.
Franchises:Call of Duty
Blood and Gore, Intense Violence, Strong Language, Suggestive Themes, Use of Drugs, In-Game Purchases, Users Interact
Platforms:Xbox One, PlayStation 4, PC
Developers:Infinity Ward
Publishers:Activision
Features:Online Versus Multiplayer
Where to Buy RTX 3060 Ti, RTX 3070, and RTX 3080 Gaming PCs (Updated)
Venom #200 Marks Two Major Milestones For Eddie Brock

redpajama_set_name: RedPajamaCommonCrawl


After stealing a machete from a market in Kigali, Munyurangabo and his friend, Sangwa, leave the city on a journey tied to their pasts. Munyurangabo wants justice for his parents who were killed in the genocide, and Sangwa wants to visit the home he deserted years ago. From two separate ethnic groups, their friendship is tested when Sangwa's wary parents disapprove of Munyurangabo, warning that "Hutus and Tutsis are supposed to be enemies."


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text:
Matisse and Picasso: A Boxing Match unto Death
It is Saturday morning DownHere in Melbourne, Victoria, Australia and I am delighted to welcome another new subscriber: E2 in Melbourne. We have several E subscribers so they must have a special interest in art. E1 in Melbourne is about to celebrate a very special birthday and so we are preparing a blog for a 90th birthday. Please send in your ideas. And a special good morning to E in London, El in London and all our subscribers and followers around the globe. Thank you for helping us foster an appreciation of art through life. And now back to Matisse and Picasso.
The analogy to a Boxing Match1 between Matisse and Picasso, two giants from the world of art, is most apt. After meeting in 1906, they continued to spar for the next 48 years until Matisse's death in 1954.
The relationship between Henri Matisse (1869-1954) and Pablo Picasso (1881-1973) is one of the most important and eventful narratives in modern art. From their first meeting in 1906, competitiveness sometimes turned to hostility and their association was characterised as a 'boxing match'. (NGA Exhibition Booklet)
After Matisse died, Picasso created a series of homages to his friend and rival. Below is The Women of Algiers (after Delacroix) by Picasso 1955 which combines Matisse's interest in Morocco and admiration for artist Eugene Delacroix's painting Women of Algiers in their Apartment 1834. While Picasso's longstanding cubist style pervades in the subject's multpile viewpoints, he channels Matisse's rich colours, complex patterning of fabrics, clothing and architectural forms, particularly the inclusion of a window. (Exhibition Label)
The Women of Algiers (after Delacroix) by Picasso
As part of his homage to Matisse, Picasso also painted The Studio (L'Atelier) as shown below where he replicates one of Matisse's favourite subjects: an interior scene with a view through a window.
The setting is of the large studio in Picasso's villa, La Californie, near Cannes. He acquired the home in mid-1955 to seek privacy from growing public scrutiny. The elaborate Art Nouveau French windows open onto a palm tree-filled garden. The lack of human presence in the composition accentuates the theme of absence. (NGA Exhibition Booklet)
The Studio (L'Atelier) (tate.org.uk)
What really impressed me as I took in the volumes of information in the Matisse and Picasso Exhibition was the way both men embraced life and change, each portraying their perceptions in a variety of ways.
Even though they came from different backgrounds - Matisse from a conservative Northern French environment, Picasso a Spanish childhood prodigy from an artistic family- they had much in common. Both indulged in a variety of mediums apart from their paintings that they are so quickly associated with.
I was interested to learn that both Matisse and Picasso were involved in working with Sergei Diaghilev - the impresario of the Ballets Russes.
Picasso was the first to succumb to Diaghilev's powers of persuasion, in fact he married Olga Khokhlova, one of the company's principal dancers. Below are some of the costumes designed by Picasso (influenced by his Spanish roots) for Le Tricorne (The three-cornered hat).
Eventually Matisse followed Picasso's excursion into designing costumes and he worked with the Ballets Russes in 1919 on Le Chant du rossignol (The song of the nightingale) as shown below.
According to the NGA Exhibition notes For Matisse the project was extremely fraught. He felt pressure to create something more wonderful and popular than Picasso and was constricted by Diaghilev's controlling oversight. Caught between emulating the ornate style typical of early Ballets Russes productions and taking a starker, more modernist approach, he attempted to do both, an approach derided by critics. (NGA Exhibition Booklet)
Ultimately, Matisse and Picasso took their initial shared interests and influences in different directions — Picasso becoming more interested in sculpted forms on the canvas which brought movement to Cubism.
Below is Large Nude on a Red Chair (Grand nu au fauteuil rouge) painted by Picasso in 1929 that demonstrates his reaction to the limitations of early Cubism, particularly its static nature.
Large Nude on a Red Chair (Grand nu au fauteuil rouge)
In contrast Matisse focused on colour and 'flattening' the image so that the background and foreground merged as one as seen below in the Reclining Odalisque.
Reclining Odalisque (Odalisque couchee) by Matisse 1926
There is so much to say about these two Art Influencers but it is time to move on. I will leave you with some words said by Matisse and Picasso about the other.
'When one of us dies, there will be some things the other will never be able to talk of with anyone else.' Henri Matisse, 1949
'Nobody ever looked at Matisse's work as thoroughly as I did. And he at mine.' Pablo Picasso, 1967
*Images unless otherwise stated were taken by Anne Newman at the Matisse and Picasso Exhibition, Canberra.
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Matisse versus Picasso
We begin to explore the friendship and rivalry between Henri Matisse and Pablo Picasso with examples from the Exhibition of their works at the National Gallery Canberra.
Anne Newman 5 Mar 2020 • 7 min read


One year ago, I launched a Patreon campaign to support the launch of my debut novel, Hot Season.
Now–365 days, 12 book events, and 1 book tour later–I'm embarking on a new adventure: Dream Studies.
These 12 speculative tales will blur the boundaries between reality and fantasy while intersecting with issues related to race, gender, class, and the environment.
As my Patreon supporter, you'll share in the journey to publication as well (with tips for revising and submitting).
This is your chance to see how an editor edits her own work–and how a working writer becomes a published author.
If you enjoy the work of these authors, chances are, you'll like these stories.
If you're new to my Patreon campaign, please consider supporting me as an emerging author for as little as $1/month. And if you're a patron who came on board to support the launch of Hot Season, I hope you'll join me on this new adventure as well!


text:
by Isabelle Arf, November 2nd, 2016
Rats is a film for particularly unobservant children.
That may sound overly dismissive if we were talking about a movie made by someone besides Morgan Spurlock, a filmmaker with the intellectual curiosity and unearned confidence of a six-year-old, but here we are, and here he is. Just like Super Size Me, Rats takes a complex issue and boils it down to talking points so numbingly simplistic that you would be forgiven thinking it was a sub-par History Channel special that somehow didn't mention Hitler, almost fanatically devoted to ignoring any and all context or complexity. If, like me, you don't find rats particularly scary (I know more than a few rat owners and I find them mostly just adorable), the film will be absolutely laughable, an infant-minded look at pest control from the perspective of someone who thinks we still live in the 1500s. Even if you do find rats frightening, I'd recommend the Wikipedia page about rats instead; it'd be more informative, more interesting, and shorter (and, probably, more frightening).
No matter how you feel, the fact is that Spurlock has said his aim was to make a "horror documentary," and he failed. If he thinks this is horror, I have some particularly spooky episodes of Scooby-Doo to show him. It's an insult to people like Rodney Ascher, who actually make horrifying docs (an even passing reference to The Nightmare would make this doc fold in on itself), and it's, honestly, an insult to rats themselves, every one of which would be a more interesting filmmaker than Spurlock, who is so on-rails that his lack of personality is basically his only discernible style at this point. This might as well be made by the most primitive documentary-making artificial intelligence possible, like if you fed an AI nothing but what you saw in school that made you fall asleep, the sex ed or safety education VHS tape of primitive rat hysteria. It has no style, no restraint, no adventurous spirit, just the most obnoxious "information" feeding possible, as loud as can be imagined, given no understanding of the broader implications of data. It's an irresponsible fluff-piece by a man so faded in relevancy that he couldn't even sustain a show on FX. When I say History Channel hour-long specials do a better job of expression, I mean it–give me a new episode of the hilarious Ancient Aliens any day over this (expensive, surely) misfire of pseudo-terrifying rat footage.
Even with his stated goal of horror, Spurlock can't stop himself from goofy sound effects, from ridiculous talking heads, from an exterminator chomping on a cigar telling tall tales about vermin in the city that defy any and all traditional logic, or even the most simple of biological investigation (or, hell, basic common sense). This exterminator tells stories so obviously untrue that Spurlock's clear belief in him is probably the scariest thing in the film, giving more proof (as if recent politics haven't given us enough) of how fear will turn even the most preposterous statements into nightmare-fulfilling, irrefutable facts. It attempts to horrify through rat gore, but anyone who has cleaned a fish would find this positively stupefying in its presumptuous edginess. It makes jukes at fear by overemphasizing the ferociousness of rats, to the point that, if Spurlock were to be believed, rats are basically vampires actively out for your precious, precious blood. And God, let's not even mention the music, which could've been made by a bored 15-year-old with a pirated copy of Fruity Loops.
Did you know that in some foreign countries, people actually eat rats? If that disturbed you, congratulations Morgan Spurlock, I'm glad to have you reading this. For anyone else though, it shows as the most inert kind of xenophobia, lazy even in its racism, like Spurlock hasn't even had the cultural adventurousness to watch Survivor, where rats are staple diet numbers one through twenty-six (number twenty-seven is rice shipped in by the producers). In high school, you knew that one girl with a weird haircut who would collect rat skulls from the forest preserve (that was me, for the record)? Well, Spurlock has less to say than her, which is to say: this film has a negative value in the world. It decrease knowledge simply by existing. To a more specific point, his invocation of hurricane Katrina is unconscionable, insulting, and so non-specific as to be politically meaningless yet somehow still disrespectful. He has no broader cultural context. He refuses to talk about other disease vectors. He refuses to talk about the circumstances which have led to rats continuing to be a major disease vector. He has no comments on the poor, the actually rat-infested, because as a rich white vegan, why would he give a shit? It otherizes its fear of rats until its stops meaning anything; its liberal xenophobia comes out like noxious puke of the white savior, condescendingly proud of these foreigners for killing rats. Spurlock can't even sustain an edit for more than ten seconds; why would I trust him with anything bordering on profundity, contemplation, or empathy? He has all the long term solutions of your friend who wants to legalize 420 now but who can't admit (or simply doesn't know) that structural racism has vastly influenced how United States drug policy is enacted. There's no nuance, there's no complexity.
This movie is only shocking for those so unfamiliar with the nature of parasites, disease, and death as to have never taken a grade school class. It would only serve to shock a newborn. If you've had the flu, even once, this will play as a particularly uninspired episode of Blue's Clues, but with the animal death quotient of Cannibal Holocaust. But for a Whole Foods devotee like Spurlock, maybe this clash between the human world and the rat world plays as exhilarating, the same way someone who's never seen a skateboard might see the most pitiful ollie as a revolution in thought. I'm a bumbling idiot when it comes to biology, and even I could see the extreme simplicity he applies to every problem, like a math major too pathetic to admit that he can't do calculus (and, like this imaginary math major, it's continually bewildering he's gotten as far as he has with an obvious dearth of ability). In short, Spurlock is too privileged, too inexperienced, too lacking in curiosity to actually have anything interesting to say about a phenomenon that mainly affects the poor, the urban, those whose landlords refuse even the simplest of pest control measures. The final five minutes (which are, comparatively, pro-rat) do not release the rest of the film from oversimplification. If your whole life has been lived in a $3000-a-month apartment in New York City, maybe this film reads as significant; for everyone else, this plays as business as usual portrayed to us by a hack of epic proportions. An intro text crawl reads: "This film contains images that may be disturbing to some viewers. We dare you not to look away." Well, Morgan, you try-hard edgelord, I never once flinched, and all I saw was shit. You made the worst film of 2016. My notes for the future: fuck off.
Directed by Morgan Spurlock; written by Jeremy Chilnick and Morgan Spurlock, based on the book by Robert Sullivan; 84 minutes.
Tags: 2016 documentary horror jeremy chilnick morgan spurlock robert sullivan
Duke Johnson & Charlie Kaufman on Anomalisa
It's Only the End of the World


I always like to give a brief shout out to new sponsors when I have them. I have a brand new sponsor, starting out for the next two months, in a company that will be relevant to a Lean audience – they are Creative Safety Supply. They are running two ads in the right hand column of the blog and they are going to be sponsoring an upcoming Podcast episode, as well.
Creative Safety Supply was built to bring you a fresh new look and modern way of doing business. We will continue to expand our product line and services to meet emerging customer needs. We know that high quality products can make your life a lot easier. We carry the best floor marking products in the industry along with the latest 5S, 6S, visual workplace, lean manufacturing, and ergonomic products to make your facility operate as smooth as possible.
Please check out what they have to offer and tell them Lean Blog sent ya!
They are describing lean as a tool with a toolbox image in their lean training website.
The website says " In its most basic form, Lean is a "toolbox" that contains a complete set of tools to help a company incrementally reduce waste and help it run more efficiently".
That said, you're right that Lean is about more than tools. I describe it as a process improvement methodology and a management system – it's a culture and a style of leadership. The Lean movement has been trying to leave the "tools age" behind. Tools have their place, but only are really successful in the right culture and environment. That's what Lean is to me – that culture where everybody can collaborate to provide the most value to our customers.
Venkatesh – I appreciate the feedback on the site you are correct this page needs work. It was created a while ago and was not done great we actually have it on the schedule to be updated.


text:
Q: How to serialize dictionary> using protobuf.net? I have a complex object which is like
Dictionary<ulong, List<MyObject>>

and MyObject is derived from
List<A>

when I want to serialize the Dictionary, it throws exception like:
[System.NotSupportedException] = {"Nested or jagged lists and arrays are not supported: System.Collections.Generic.List`1[[xxxx.MyObject, xxxx, Version=0.0.1.0, Culture=neutral, PublicKeyToken=null]]"}
How to solve it?
My protobuf is version 2.3.2.0

A: The problem here is the list-of-thing-that-is-a-list. That simply isn't supported as it can't be expressed in the underlying protocol (protobuf).
Options:

*

*switch to a list of something that isn't a list but which has a list

*keep your existing model, but set the "ignore list handling" flag on your custom type (the one that subclasses list), and expose the list contents via a property

redpajama_set_name: RedPajamaStackExchange


Delivery for $70 plus orders is free to Adelaide CBD, Adelaide Suburbs, Adelaide Hills, Strathalbyn and Langhorne Creek. Additional Freight charges may apply to bulky items such as furniture. Please ask for a quote for all other areas and interstate delivery..


text:
Article Published in Journal of Language and Verbal Behaviour
Posted by Joseph Conte in Publications
"The Intratextual Obscurity of Louis Zukofsky's "A"." Journal of Language and Verbal Behaviour [Язык и Речевая Деятельность] 9 (2009): 26-32. The Linguistic Society of St. Petersburg. St. Petersburg State University, Russia.
Louis Zukofsky's late poetry in the book "A" constitutes a kind of "intratext," a poem that resides between two languages, dependent on a source text, but representing an original work on the part of the author. The bilingual character of the poem is not a translation, which traditionally emphasizes the carrying over of the sense of the original into the target language at the expense of sound, style and other poetic effects; rather Zukofsky emphasizes sound and style at the expense of a literal rendition. This compositional strategy creates a special kind of literary diffi culty that is not merely allusive of other works of literature, but a deliberate obscurity that appropriates and reconstitutes its source texts in the pursuit of an idiosyncratic linguistic beauty.


At ANU, one of the top 10 universities in the world for environmental science and the best university in Australia1, our goal is to produce influential graduates who can help to shape sustainable futures. Our award-winning courses and teachers at the Fenner School of Environment and Society deliver innovative, high-quality education that combines excellence in fundamental knowledge with cutting-edge advances in thinking, and exciting opportunities for engaging in hands-on science.
Our Master programs in environmental science are designed to build on your prior knowledge to extend and deepen your understanding in one or more of the biological, Earth, and environmental and ecological sciences. You will also develop your knowledge across the environmental sciences.
This program is for students wanting to increase their scientific and professional expertise for careers in many aspects of environmental science, including environmental policy, management, administration, industry, services and research. Examples of roles of our graduates include: Technical Officer, CARE International; Manager, National Water Commission; Assistant Director, EcoTrust; Research Associate, Scripps Institution of Oceanography (USA); and Researcher, Wildlife Conservation Society.


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You will receive (2) Pink Silk Peony Heads (No Clips) with Florist Brand package individually as shown.
You'll obtain (2) Peony Heads (No Clips) with Florist Logo bundle for my part as proven. ::Measurement:: Each and every head is roughly 4 inches throughout. ::Subject material:: Artificial Silk polyester And Made in Singapore. – Just right Concepts for embellishing weddings, events, hair clips, headbands, hats, garments, bows, craft paintings.
You'll obtain (2) Purple Silk Peony Heads (No Clips) with Florist Logo bundle for my part as proven.
Made out of Artificial Silk polyester And Made in Singapore.


So, what is Crystal World?
Click the image to learn more about the Enchanted Castle crystal figurine.
Since 1983 Crystal World has been creating exceptional full-cut faceted crystal figurines. Founder Rudy Nakai is an outstanding crystal artist, as are Tom Suzuki, Roy Takii and other designers on the Crystal World team.
The Crystal World designers are known for their ability to depict emotion and personality in crystal. This is a very difficult medium to work with, taking months to create and approve a new design. Crystal components for Crystal World's figurines come from around the world: Austria, Turkey and China are just a few of the countries that supply the pieces that make up the crystal figurines.
In 1987 Crystal World launched a new trend toward colored crystal with the introduction of the Original Rainbow Castle Collection®. This revolutionized the marketplace and crystal figurine collecting worldwide.
In 1998 Crystal World introduced its Disney Snowcase Collection, taking the medium to a whole new level. This collection featured charming replicas of some of Disney's most popular characters, such as Dumbo, Bambi and Mickey and Minnie. The collection was retired at the end of 2003, but Crystal World's Disney crystal figurines can still be found on eBay and in other secondary markets.
Crystal World's Peanuts® Collection was introduced in 2004. These beloved crystal figurines honor the legacy of Charles Schulz. Snoopy, Charlie Brown, Lucy, Woodstock and others are represented in this popular collection.
Crystal World's artistry in full-cut faceted crystal has been honored with numerous prestigious awards for artistic achievement. Four figurines have received the Award of Excellence, selected by readers of Collectors Editions magazine. Cinderella's Castle received First Runner-Up for Architectural Structure of the Year from the the National Association of Limited Edition Dealers. It also received top honors from Collectors Editions Magazine. Crystal World has also received numerous Best of Show awards at International Collectibles Expositions.


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Q: Draw text method not working I have a method to draw a string in a rect, but it is not working for some reason.
Here is the code:
- (void) drawString: (NSString*) s withFont: (UIFont*) font inRect: (CGRect) contextRect {

    CGFloat fontHeight = font.pointSize;
    CGFloat yOffset = (contextRect.size.height - fontHeight) / 2.0;

    CGRect textRect = CGRectMake(0, yOffset, contextRect.size.width, fontHeight);

    [s drawInRect: textRect withFont: font lineBreakMode: UILineBreakModeClip
        alignment: UITextAlignmentCenter]; }

Thank You!

A: You have two choices here. You can implement "drawRect:" in some custom view you write, add a property to that view to set the string, and when you want the string updated tell the view to redisplay:
[myCustomView setNeedsDisplay];

If on the other hand you want to get the string into an image, you will use a different means to open a graphics context, draw the string into the context (a bitmap), then get an image created from the context.


text:
Alberto Egea (29 August 1901 – 13 December 1958) was a Venezuelan artist. His work was part of the art competition at the 1932 Summer Olympics.

References

1901 births
1958 deaths
Venezuelan artists
Olympic competitors in art competitions
People from Caracas

redpajama_set_name: RedPajamaWikipedia


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NYPD Blue – The Complete Fourth Season
Posted in: Disc Reviews by Gino Sassani on June 27th, 2006
Released Tuesday, June 20, 2006
Dolby Digital 2.0 (French)
So now we come to the fourth year of NYPD Blue. In the show's ever-changing look this year was no exception. Most notable is the fact that a new camera operation crew toned down the jumpy camera moves a bit. Style was not sacrificed, but the series is now easier to watch. Smits and Franz are really starting to click now, and we begin to see the special relationship we know will evolve between their characters. This buildup is absolutely necessary for the coming payoff with Simone's death in later years. Again, several characters came and went, most notably a couple of female detectives. I've heard the show described as testosterone heavy, but I can't believe that could be said of year four.
Greg Metavoy gets a lot more to do starting this year, and I think you'll find the results entertaining. This is the only character other than Sipowitz to survive the show's entire run. He's placed in some awkward moments in year 4. The Simone and Russell romance heats up, and while I tend to think these things cheapen a series, I found this one to be tolerable. It was also quite necessary for the eventual payoff mentioned earlier. As always, NYPD Blue is about Andy, and you won't be disappointed. The character continues his wonderful growth in this season, mostly aided by the influence of Simone. There's plenty for every Blue fan out there in this set.
Each episode of NYPD Blue is presented in its original full frame broadcast ratio. Yeah, it's still grainy. Colors, however, stand out in stark contrast to the dark stories being told. The streets of New York (OK, mostly it's not really New York) look crisp and sharply defined. Black levels are very nicely done. The art is in the details, and this transfer has it. All of this is enhanced by the smoother camera work.
The Dolby Digital 2.0 track delivers everything you'd expect it to. I must admit, that percussive theme song wears on me, but there's no question its very nicely done here. Dialogue is everything in cop shows, and you won't be disappointed here. You'll hear every word all the time. Musical cues are bright, perhaps too bright at times.
There are some commentary tracks which include mostly production staff.
"In With The New" is a look at the five new characters to join the show this season:Lourdes Benedicto playes PDA Gina Colon; Debra Christofferson playes the PDA that sexually harasses Andy; Willie Coarson is the only male added to the cast, and serves as a thorn in Simone's side; Andrea Thompson and Paige Turco join as new detectives in the squad. This feature spends about five minutes letting each tell you about their character and what the overall NYPD Blue experience was like.
"Through The Lens: The Look Of Blue" is a 20 minute look at the process that gives the show its unique look. They say imitation is the sincerest form of flattery. Blue is certainly one of the most copied looks on television. Here's why and how they do it..
The word groundbreaking is vastly overused particularly among reviewers. I try not to abuse the phrase, but if it doesn't apply to NYPD Blue, then it just shouldn't be used at all. Truth be told, most of the successful formula Bochco uses here was developed on Hill Street Blues, a true masterpiece of its own. It seems that after years of slow season releases, Fox has begun to speed up the process. That can only be a good thing for you Blue fans out there. With five more to come, I would think that "You wanna get out in front of this thing now."
Tristan & Isolde Dare to Play the Game


text:
seasidehalfmarathon.com
Deadly Yeast Infection
Over the past few years, C.
This is vital to keeping Candida infections at bay. Youtube, having a certain amount of candida throughout your body is normal, and it's usually kept under control by local bacteria and the body's immune system. History of Candida Auris: It causes bloodstream infections, wound infections, and ear infections. Knowing that C auris likes to colonize the skin, they theorized that patients colonized with C auris might be contaminating their surroundings by shedding skin cells that contain the fungus. " The British government commissioned a study which predicted a worst case scenario where more people will die by 2050 of these infections than will die of cancer. This means that affected patients and contaminated surfaces or equipment pose a major risk.
What sort of illness does it cause?
Although these problems are uncomfortable and debilitating, they are not fatal.
The most common Candida (C) species to result in candidiasis is C.
A diaper tends to provide an ideal environment for Candida.
This starts with placing infected patients in single rooms that are cleaned daily with EPA-registered disinfectants.
But the list of what's not known about this highly unusual fungus is longer still — and fascinating. Candidal musculoskeletal infections were once uncommon; recently, they have become much more common, possibly due to the increased frequency of candidemia and disseminated candidiasis. The pathology collection centre may require the person to collect the groin swab for themselves or for their child and will provide instructions on how to do this. But the fungus, which can cause infections, including of the blood, of wounds and ears, has three main features that make it worrisome to health-care professionals: But, as global temperatures have risen, C. 9 effective ways to treat and fend off yeast infections for good. Candida auris:
The condition may produce intermittent urinary tract obstruction with subsequent anuria and ensuing renal insufficiency.
But, given that people who develop the infection usually have another underlying illness, it can be tough to spot Candida auris from symptoms alone. Candida auris is difficult to treat. Conventional lab techniques could lead to misidentification and inappropriate treatment, making it difficult to control the spread of C. Scientists first discovered C. Findings reveal disfiguring lesions of the face, scalp, hands, and nails. Some of the patients in that outbreak developed resistance to an entire class of antifungal drugs within a month — "which is just unheard of," she said. Patients with suspected or confirmed C. To stay informed on the latest in infectious disease news and developments, please sign up for our weekly newsletter.
According to the Centers for Disease Control and Prevention (CDC), 30–60% of people with C. In vitro, more than 90% of C. Any invasive infection, which includes bloodstream infection with any Candida species, can be serious and even fatal. Your doctor will likely be able to make a diagnosis simply by performing a physical examination. Those with central venous catheters or other lines or tubes entering the body, such as breathing, feeding tubes or intravenous fluids are particularly susceptible. Until that happens, it will be a challenge," she said. "The physical examination findings are generally unremarkable, and the diagnosis is frequently made with direct or indirect laryngoscopy. We continue to identify technical compliance solutions that will provide all readers with our award-winning journalism.
Hospitals are scared of driving away patients. Researchers discovered C. " "There's always this response like, well, but there's still a drug, right? NCCID Disease Debriefs provide Canadian public health practitioners and clinicians with up-to-date essential information on prominent infectious diseases for Canadian public health practice. To find some clues, Chiller's team peered into the genome of C. How is candida diagnosed?
What about in Maryland?
Sign up for Daily Recap
Here's what you need to know about this mysterious infection—and why it should at least be on your radar. Don't worry too much about hygiene or trying to keep them healthy. Despite the recent attention, we've known about C. That heat tolerance could contribute to its emergence as a fungal disease in humans. In 2020, South Korea saw its first cases of disease-causing C. " Centers for Disease Control and Prevention, U. Use alcohol-based hand sanitizer when soap and water are not available. The symptoms of a C.
Specialty Focus
Whereas this just seems to stick there," Fauci asked. No one knew where it came from or how to prevent its spread [4]. " Read up on 10 dangerous superbugs you should know about. Most of the clinical cases have been found in New York, Illinois and New Jersey -- with 309, 144 and 104 confirmed cases, respectively.
Vulvovaginal candidiasis (VVC): If these powerful drugs do not work, the patient may be escalated to treatment with a highly toxic antifungal called amphotericin B. " Say your grandmother makes you a rump roast. "Excess use of antibiotics are providing an environment in which Candida auris can occur," he says. However, chlorhexidine gluconate, iodinated povidone, chlorine bleach and hydrogen peroxide vapour appear to be effective against C. This means it has evolved to a point where it cannot be controlled by drugs or other anti-fungal treatments.
It then started showing up in hospitals in Asia, Africa and South America in patients without a clear link — and no one could figure out why.
This is why doctors need to do a laboratory test to confirm the presence of C. It can develop in a variety of places, including in an open wound, the bloodstream, or the ear. Candida endocarditis is associated with 4 main risk factors, including intravenous heroin use (frequently associated with C parapsilosis infection), chemotherapy, prosthetic valves (approximately 50%), and prolonged use of central venous catheters. "The more ubiquitous it becomes, the more problematic. Most of the recent cases have occurred in New York City, New Jersey and Chicago, according to the CDC. Worse, it can spread throughout healthcare facilities such as hospitals and clinics very quickly, infecting everything in its path. Wash your hands with soap and warm water, especially before eating or preparing food, before and after changing wound dressings or bandages, after using the bathroom, and after blowing your nose, coughing, or sneezing.
Improving diagnosis will help to identify patients with C. The common species of candida are usually found on culture, but sometimes one of about 15 other species are detected, such as: But you can get colonized. Organic agriculture lauds the use of animal manure. The most common symptoms are a fever and chills that don't get better with antibiotic treatment, the CDC says. These sites include skin, urine, external ear, wounds, and respiratory specimens. People who have been hospitalized for a long time, have a central IV or other lines or tubes entering their body, or have previously been given antibiotics or antifungal medications seem to be at the highest risk of contracting the infection, which is why Dr. In vitro antifungal susceptibility testing showed 100% strains to be resistant to fluconazole (MIC 32 ≥ 256 mg/L) while variable resistance against other antifungal agents.
The two primary forms of infection include the exogenous infection and the endogenous infection. It often infects people who have had frequent hospital stays or live in nursing homes. They can still spread it to other patients if precautions aren't taken. The physical examination reveals a broad range of manifestations, including feverunresponsive to antimicrobials, hypotension, shock, new or changing murmurs, and large septic emboli to major organs, a characteristic of fungal endocarditis. Infection experts advise visiting family members to wear gowns and gloves and to vigorously wash their hands and never touch these 10 things in hospitals. So did the samples from Asia and from South America. A pruritic red rash develops.
The research is presented at ASM Microbe, the annual meeting of the American Society for Microbiology. It's a fungus called Candida auris (C. )In women, vaginal yeast infections are the second most common reason for vaginal burning, itching, and discharge. Another 1,056 patients were found to be carrying the fungus without signs of infection, the CDC said. About 54% of recognized U. What's known about the fungus Candida auris confounds the scientists who study it, the doctors who struggle to treat the persistent infections it causes, and the infection control teams that endeavor to clear it from hospital rooms after infected patients leave. One case was diagnosed in 2020, with two in 2020, a health department spokeswoman said in an email. Approximately 15% of patients develop systemic candidiasis.
Genitourinary Tract Candidiasis
Erythematous candidiasis: But fortunately, Candida auris has not spread to wide swaths of the population, and healthy people rarely develop the infection. The emergence of a partially drug-resistant fungal infection in Canadian hospitals and elsewhere has doctors and scientists scrambling to understand the pathogen and stop its spread. Governments across the country and world have often been cautious about creating panic, choosing not to explicitly publicize such incidents. The majority of fungi grow well in ambient temperatures but only a small percentage can tolerate our body temperature.
People with already-compromised immune systems are especially vulnerable, while hospital outbreaks have led to both confusion and secrecy. Often, patients use windowsills as shelves, so it would make sense for the organism to spread there too. Most occurred in medical centers, nursing homes, and long-term care facilities, and affected people who were already ill.
Scientists typically diagnose fungal infections by trying to grow the fungus from a person's blood or other body fluids in a laboratory.
These infectious residues can transmit C. Yeast dermatitis in dogs: the good, the bad and the ugly. Until public health authorities put out alerts about the fungus and doctors began actively looking for it, "we weren't aware that Candida auris was such a big issue," Eyre said. Schaffner says. They also tested a variety of surfaces in patient rooms — bed railings, doorknobs, and windowsills. Candidiasis can cause a wide spectrum of clinical syndromes, as described below.
Science can't yet say where it came from or how to control its spread, and hospitals are being forced back into old hygiene practices—putting patients into isolation, swabbing rooms with bleach—to try to control it. Healthy people usually do not get C. They then counted the amount of C auris they found in each sample using a method they derived to quantify the concentration of the fungus. Vaginal yeast infections, wearing a wet swimsuit for many hours may keep your genital area warm and moist. A deadly fungal infection that is resistant to major antimicrobial medications is spreading globally, and scientists aren't sure where it came from. Candida auris infection is difficult to diagnose, and missed diagnosis may lead to spread. Thrush and breastfeeding: symptoms, causes and treatments, it's possible to reduce your chances of getting thrush again. Generalized cutaneous candidiasis: Since it was first reported from Japan in 2020, C. Canada's first case of multidrug-resistant C.
How can you prevent Candida auris? Follow your healthcare provider's instructions. The ease at which Candida auris spreads is be due to its ability to target patients who are already ill with another infection, or who have weakened immune systems. What they found was that the colonized patients had varying amounts of C auris on their skin, with some having high concentrations, and that higher levels of C auris on patients' skin was associated with higher levels of C auris on their bed rails. Wounds are bandaged to prevent any fluids from seeping out and infecting others. But when the genetic sequences were compared, it was clear that was not the case. Most patients with Candida tracheobronchitis are HIV-positive or are severely immunocompromised.
10%), and wound (13. It can be identified accurately using matrix-assisted laser desorption ionization time-of-light (MALDI-TOF) mass spectrometry instruments with databases that include C. Overall, there were 540 clinical isolates tested, with 413 testing positive for C. There have been outbreaks across the world, and new research shows higher temperatures may have led to an increase in infections. The authors say that historically the human body temperature has acted as protection against invasive fungal infections — in effect, we're too hot for them to be able to grow well in us. " "Did we pay any attention to that? Not all hospitals identify C.
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Healthcare professionals need to know that people who spend a long time in hospitals, nursing homes or are immunocompromised are at high risk. Does hydrogen peroxide cure these ailments?, the gyrodactylid recovery rate of the non‐lethal (chemical) method was assumed to be represented by the probability of a parasite being removed from fish during the treatment (average number of parasites found on a filter paper divided by the sum of the number of parasites on the filter paper, in the holding water and remaining on the treated fish), multiplied by the probability of recovering a parasite from the system. We are engaged on the issue and committed to looking at options that support our full range of digital offerings to the EU market. Simple solutions such as cleanliness may be the most effective and practical, including wearing gloves and gowns and washing hands [4]. Some — but not all — of the resistant infections were acquired in hospitals outside Canada, Maddison said. Because now it could potentially transmit DNA to other Candida species.
Instead, you can take constructive steps to deal with concerns about a wide array of infections, even the deadliest ones:
Candida auris often doesn't respond to common antifungal drugs. Myocarditis-pericarditis occurs as diffuse abscesses scattered throughout the myocardium surrounded by normal cardiac tissue. Previous experience suggest that multi-drug resistant (MDR) C. This means it's possible to use a variety of treatments at the same time, thus reducing the chance of resistance. When patients are diagnosed with C.
Tirupathi is medical director, infectious diseases/HIV at Keystone Health, and chair, infection prevention, at Summit Health, both in Chambersburg, Pa. What are the symptoms of Candida auris infection? Isolates are less susceptible to antifungals than other Candida species, although patterns of susceptibility appear to be related to the geographic clade. Candidiasis of the skin often causes a red, itchy rash to form, most commonly in the folds of the skin. To find out more about how information is collected, see our page dedicated to the Disease Debriefs.
Microbes, including yeasts, can adapt in ways that allow them to become resistant, and those that become stronger and resistant have the opportunity to survive, reproduce, and spread [5].
According to the Public Health Agency of Canada, about 20 cases of C. Oil pulling and oral thrush » the candida diet, " Perfumed products (including fragrant laundry detergents) are a frequent culprit behind unhappy vaginas. Amphotericin B resistance also has been seen in about 30% of isolates. Add probiotics to your diet. Researchers have noted that these infections seem to be popping up all over the world, rather than being spread from one site to another. There were sick people that C.
Normally, yeast hangs out in warm, damp spaces in the body, and surges out of that niche only when its local ecosystem veers out of balance. Endogenous endophthalmitis results from hematogenous seeding of the eye. Recently STAT asked a number of scientists to describe what they see as the most pressing research questions facing the field. This is the second most common cause of vaginitis.
It is difficult to treat, and its multidrug resistance also leads to concern of further transmission. The fungus doesn't behave like a fungus. The infection is found predominantly in the hair follicles and, rarely, can become extensive. This fungus is really hard to get rid of. "Money gets made over the sale of antibiotics. That's a question Bouklas is wondering about. Although the researchers didn't directly measure skin shedding, Sexton said the connection between the amount of C auris on patients' skin and their beds is consistent with their hypothesis, and should be considered as hospitals try to devise strategies to control the spread of the organism.
Symptoms may not be noticeable because patients with C. Symptoms of fungal and yeast infections, while treating this infection, good bacteria in the vagina is killed. This is an unusual form of cutaneous candidiasis that manifests as a diffuse eruption over the trunk, thorax, and extremities. In most situations, precautions should be continued for the entire duration of the patient's stay in a healthcare facility. Because of this, less common antifungal drugs have been used to treat these infections, but C. According to the CDC, more than 90% of C.
That left only one set of drugs available, a new IV-only class called echinocandins. What does this yeast do to people? Affected sites include the following:
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People most at risk of contracting Candida auris include patients who have endured long hospital stays, people with compromised immune systems, those who have a central venous line or other tubes in their bodies, and people who have previously received antibiotics for fungal infections, according to the CDC and state health department. But when scientists went looking for C. Given these challenges, it may be easy to see how the outbreak continued for so long. The time taken to identify C. What are the signs and symptoms? The organism is discovered in the ear of an elderly woman in Japan.
Practice And Service Quality
In general, residents of nursing homes who have C. Thrush symptoms, prolonged oral treatment is sometimes required but should be based on a yeast culture. The rash occasionally spreads to the thighs, gluteal folds, buttocks, and scrotum (see image below). Treatment is also complicated because it is easily misidentified as other Candida species. Here is everything you need to know about this new superbug.
Just give them antibiotics. Lesions are 3-dimensional and extend into the vitreous off the chorioretinal surface. Yeast infections: symptoms, diagnosis & treatment, does yeast infection smell bad? It's a cross-species shift as inexplicable as if a grass-munching cow hopped a fence and began bloodily chomping on the sheep in the pasture next door. Here's what you need to know about it. Cleaning the room with different products than usual. There are three main classes of antifungal medications, and some Candida auris infections are resistant to all of them. "That's a generation from now. Involvement of respiratory, urogenital, abdominal, skin and soft tissue sites have been reported as well.
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Celebrities>Culture
Alec Baldwin Awards Vegan Companies Beyond Meat and Impossible Foods the United Nations 'Champion of the Earth'
US-based vegan meat companies Beyond Meat and Impossible Foods are the new UN Environment's "Champions of the Earth."
"We're BEYOND honored to have been recognized by the @unitednations as a 'Champion of the Earth' tonight!" Beyond Meat said an Instagram story.
The award was presented by actor and activist Alec Baldwin, a keen advocate for solutions to climate change and the environmental challenges our planet currently faces. He is also a vegan for health reasons, and in the past, he has teamed up with the Physicians Committee for Responsible Medicine to promote a plant-based diet of foods such as nuts, grains, fruits, and veggies, over more convenient options, like meal replacement bars.
An agency of the United Nations, the UN Environment is the leading environmental authority globally, setting the environmental agenda worldwide. Beyond Meat and Impossible Foods were recognized by the organization for their "pioneering" work in helping to build a new food system and eradicate factory farming.
"Our use of animals as a food-production technology has brought us to the verge of catastrophe," the UN Environment said in a press release. "The destructive impact of animal agriculture on our environment far exceeds that of any other technology on Earth."
It continues, "The global community can eliminate the need for animals in the food system by shifting the protein at the centre of the plate to plant-based meat, say the founders. For their pioneering work towards reducing our dependence on animal-based foods, Ethan Brown and O'Reilly Brown have been selected 2018 Champions of the Earth in the category of science and innovation."
The positive impact of vegan meat on the planet is significant. According to a recent study by Beyond Meat, a Beyond Burger patty uses 99 percent less water than a traditional 1/4 lb beef burger, 93 percent less land, produces 90 percent fewer greenhouse gases, and 46 percent less energy.
"What's clear is that the way we produce meat today is not sustainable," said Brown in a statement. "We are pushing limits on both natural resources and atmosphere."
He added, "We believe that by transitioning acreage currently dedicated to animal feed into protein crops that can be used directly for human consumption in the form of meat from planets, we can bring a step-change in efficiency, much needed innovation, and sustainable economic growth to rural economies here in the US and abroad."
Image Credit: Beyond Meat
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STROUDSBURG — The Pocono Arts Council is offering two $500 scholarships for graduating seniors in music and visual art who plan to continue their art education at the college level.
The scholarships are available thanks to a bequest by long-time local art supporter Suzanne Anderson. The deadline for applying is April 15.
The winning recipients are invited to this year's Spring for the Arts Event on June 8 to receive their award.
Further information and applications are available by calling 570-476-4460 or emailing director@poconoarts.org.
The Pocono Arts Council is a local arts service organization serving Monroe, Pike, Wayne, Lackawanna and Luzerne counties. The mission of the council is "Culture Builds Community" — to build the community artistically and culturally by providing leadership, service, and education.
For more information visit poconoarts.org.


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Four generations of farming in the Olson family
By Melissa | November 10, 2014
By Kelsie Hoitomt
CONNORSVILLE — This week's "Farm Feature" highlights the fourth generation dairy farm that is now owned by Steve and Angie Olson.
After taking over the dairy farm in 2008 from his parents, Pork and Carol, Steve and his wife Angie decided to name their place Maple Hills Dairy.
Prior to the change in ownership, Steve was in a partnership with his parents for 13 years.
The dairy farm began years ago with Steve's great-grandparents, Karl and Clara. From there, it was Clyde and Muriel and then Pork and Carol.
In 1998, Steve and Angie moved into their home, which is just up the road from the original farm at Pork and Carol's on the outskirts of Connorsville.
In 2008, he and Angie came to the conclusion that dairy farming had to be easier than it was so they made contact with a company that aids in the installation of milking parlors.
Once the parlor was in, they expanded their herd and now they have around 70 cows and 70 young stock including those on their own property that are milked, the calves across the road at Pork and Carol's and the dry cows at another location near by.
The farm consists of four locations, which covers roughly 496 acres. They recently purchased a property that has two sheds, a house and crop land.
They are using the sheds for additional storage and the house is where their hired hand lives.
According to Steve, they crop mostly alfalfa and corn with typically 130 acres of corn, 130 of alfalfa, 50 of oats and around 50 for soy beans.
The majority of their crops are kept in house and put into a TMR mixer, which is in turn fed back to their own livestock.
When asked about prices over the years, Steve stated that the fluctuation in crop prices over the years hasn't affected them as deeply due to growing and feeding of their own.
However, milk prices on the other hand are something that has a large impact.
"This year has been excellent, but when we took over in 2008 that was the bad year, milk was about ten dollars," explained Steve.
The numbers more recently have roughly been at the $24 to $27 range, but that is also an all time high so an average of $17-18 is more of what they look for.
"Milking is more stable. In dairy there's about one or two bad years out of 10 versus crops there could be three or four in that ten from what I hear," said Steve when asked whether milking or dairy farming is more profitable in terms of stability.
"I think there are more headaches with dairying though, its constant versus peak seasons and down time with crops," Steve said.
Steve laughed as he shared that maybe one day he would consider crop farming when he wanted to slow down, but for now it is dairy full speed ahead for the Olson family.
"I've always liked animals and one thing I don't like about just crop farming is I like seeing hay on the land and grass," explained Steve. "We pasture a lot of ground, probably 150 acres… we have cattle all over, had some by Glenwood… you don't see much of that anymore. I'm not exaggerating when I say we have at least 10 miles of fences to maintain."
The cows at Maple Hills Dairy enjoy free range pasturing all year round, but when the cleaning system kicks on for the parlor, they know to come running to the barn.
The cows are milked twice a day with the help of their hired hands, one full time and three part time workers and then Steve himself two or three times a week.
Pork still helps run the tractors and he does field work and he and Carol will help feed the young stock as well.
Steve and Angie both praised their workers for their excellence, which has helped keep them off the farm.
With two young children- Megan and Nick, Steve and Angie are busy running to programs and sporting events so being able to rely on good help has been very appreciated by them.
Aside from the farm and children, both Steve and Angie have full time jobs as well.
Steve has spent 14 years working for St. Croix County. He is currently in the Community Development Department, which has become a conglomerate of programs such as Planning and Zoning and his area of expertise- Land and Water Conservation.
Prior to that, he also worked in the Land and Water Conservation Department in Dunn County.
Steve shared milking and working a separate job is a unique trait that the Olson family carries.
Karl was a carpenter and milked, Clyde was a milk hauler and milked and Pork was a carpenter and managed a lumber yard and then milked.
In those days, Karl was managing around 40 acres of crop land along with his dairy cows and Clyde had around 240 acres.
Steve shared that in those days, they typically grew a little bit of corn and then some barely with the majority being hay. Steve is now the first generation to grow soy beans.
Steve is the first generation to use the milking parlor as was stated. Prior to this, he grew up first using milking buckets, then they had a step saver and prior to the parlor they had a pipe line.
Steve shared that one day he hopes to upgrade to using a robot, but that is a few years out.
As far as milk, the liquid is picked up by Steve Nelson Trucking and is sent to AMPI in Jim Falls where it is transformed into cheese.
One of the big contracts AMPI has is with pepper jack cheese, which is sold to a wholesaler and then in turn sold to the food franchise, Subway.
It is their milk that has given Maple Hills Dairy great recognition over the years.
Their cows have produced quality award winning milk, which was given to them by the AMPI Co-op for having less than a 200,000 somatic cell count for ten out of 12 months.
Away from the farm and their jobs at the County and Bremer Bank – Angie has worked for Bremer for 22 years – the Olsons keep busy in a variety of ways.
This past fall Steve helped coach his son's football team and he is an avid hunter with several trophy bucks on display in his home.
Aside from football Nick also plays basketball and baseball. Megan too plays basketball as well as volleyball and softball, she runs cross country and she is an avid dancer.
In their spare time as a family, they like to go camping every summer and spend time fishing and tubing on the water. In the winter months they like to travel some place warm.
Aside from their milk recognitions, the Olsons were recently honored with hosting the 2015 Dunn County Dairy Breakfast.
They will now open their farm up to visitors on June 6, 2015 and the County will provide a large waffle breakfast buffet that is available for $5.
"It is definitely appreciated and a huge honor," expressed the Olsons.
Posted in Boyceville, Home, News
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Nikki Sixx 'Did Not Hesitate' When Invited on 'American Idol'
Corey Irwin Published: March 18, 2022
YouTube / ABC
Nikki Sixx will make a guest appearance on American Idol in an episode airing this Sunday, March 20.
The reality TV show, now in its 20th season, hits the Sunset Strip in the latest round of auditions, with Sixx serving as the ambassador for the famed music scene.
"Listen, if anybody wants to hear about the stories of the Sunset Strip…" show judge Lionel Richie proclaims in the episode's teaser video (see below), before pointing at the Motley Crue bassist.
"It was a lot of fun to team up with American Idol upon the show's return to L.A. After all, Motley Crue are also from L.A., and so many amazing songwriters call Los Angeles their 'Home Sweet Home,'" Sixx explained in a statement to Billboard.
"Because of American Idol a lot of great, timeless, classic songs have not only been re-interpreted by the next generation of talented singers but have also been re-introduced to mainstream audiences and younger generations of music fans for the last two decades," the rocker continued. "As a songwriter myself, that's something I really appreciate so when I was invited to appear on this Sunday's episode I did not hesitate."
Sixx is no stranger to reality TV. The legendary bassist appeared on several episodes of LA Ink, as well as his bandmate Tommy Lee's short-lived series Battleground Earth. Appearances on Dr. Phil, Piers Morgan Live, Behind the Music and a stint as a panelist on Hollywood Squares are among his further television credits.
Motley Crue are set to embark on the Stadium Tour alongside Def Leppard, Poison and Joan Jett starting in June.
American Idol airs Sunday and Monday night at 8pm on ABC and streaming on Hulu.
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Filed Under: Motley Crue, Nikki Sixx
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Huth agrees to join Middlesbrough
on Sunday, 11 June 2006 at 4:09pm
Robert Huth will join Middlesbrough after agreeing terms on a five-year deal which he expects to sign after the World Cup.
Chelsea and Boro agreed a fee last week and Huth announced today: "I have spoken with the manager, Gareth Southgate, and have promised him I will join Middlesbrough for the new season. The paperwork hasn't been completed as yet but I have told [him] that I will sign the contract when it is ready."
PlayersTransfers
World Cup news - day 3...


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Hamden mayor opposed to easing of gun control laws
HAMDEN - Mayor Scott D. Jackson is proud to announce his unity with Mayors Against Illegal Guns in opposing the "Concealed Carry Reciprocity Bill" (H.R. 822). The law would force states to recognize the concealed weapons laws of other states, regardless of how lax the laws are.
Mayor Jackson is joined in the "Our Lives, Our Laws" campaign by over 550 Mayors nationwide, including Mayor John DeStefano of New Haven and Mayor Bill Finch of Bridgeport.
"The safety of our community is my number one goal and I am proud to oppose any law that infringes on our ability to do that. This law would make it easier for a slew of undesirable people to attain guns in our state that were previously unable. Please join me in this oppositionk," said Jackson.
Visit www.hamden.com for the latest Town updates and follow on Facebook at "Town of Hamden" and on Twitter via @townofhamden.