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text:
A Vice-President of the European Commission is a member of the European Commission who leads the commission's work in particular focus areas in which multiple European Commissioners participate. Currently, the European Commission has a total of eight vice-presidents.

Role and benefits

The role of vice-president of the European Commission may be bestowed on any European Commissioner in addition to their existing portfolio.

Since the 2009 Lisbon Treaty entered into force, the High Representative of the Union for Foreign Affairs and Security Policy is ex officio one of the vice-presidents. The other vice-presidents are appointed at the discretion of the Commission President.

Commission salaries are set as a percentage of the top civil service grade. Vice-Presidents are paid at 125% (€22,122.10 monthly), in comparison to 112.5% (€19,909.89) for normal Commissioners and 138% (€24,422.80) for the President. However, the vice-president who also serves as the High Representative is paid at 130% (€23,006.98). There are further allowances on top of these figures.

First Vice-President
The First Vice-President usually takes on the main role of a vice president: taking over from the President in their absence. Frans Timmermans is the incumbent First Vice-President having served in the position since 2014 in both the Juncker and von der Leyen Commissions.

The position was established under the Barroso I Commission in 2004, with its first occupant being Margot Wallström. She was succeeded in the second Barroso Commission by Catherine Ashton who was also the High Representative of the Union for Foreign Affairs and Security Policy.

Executive Vice-President
The von der Leyen Commission established a new position of Executive Vice-President. There are three Executive Vice-Presidents, one of whom is the First Vice-President, who in addition to their other roles also manage a policy area, with a specific Directorate-General under their authority for this part of their job.

Historical vice-presidents

Legend:    –  –

 First Vice-Presidents are in italics.
Executive Vice-Presidents are in bold.

References

External links
 European Commission Website ec.europa.eu

redpajama_set_name: RedPajamaWikipedia


text:
Bodysong is the debut solo album by Radiohead guitarist Jonny Greenwood. It is the soundtrack to the documentary film of the same name. It was released on October 27, 2003 in the UK and on February 24, 2004 in the United States.

It was digitally remastered and reissued on CD and vinyl on 18 May 2018. Greenwood's brother, Radiohead bassist Colin, plays bass on the album. It is notable for be the first "solo" album released by any member of Radiohead. Currently, Colin Greenwood (Jonny's brother) is the only Radiohead member that has not yet released any solo material.

The piece "Convergence" was used in Greenwood's score for the 2007 film There Will Be Blood. The inclusion of the track along with excerpts of another Greenwood piece, "Popcorn Superhet Receiver", disqualified the score from the 2008 Academy Awards, as scores cannot contain pre-existing music.

Track listing
 All songs written and produced by Jonny Greenwood:
 "Moon Trills" – 5:17
 "Moon Mall" – 1:12
 "Trench" – 2:38
 "Iron Swallow" – 2:07
 "Clockwork Tin Soldiers" – 3:48
 "Convergence" – 4:26
 "Nudnik Headache" – 2:16
 "Peartree" – 3:06
 "Splitter" – 3:57
 "Bode Radio/Glass Light/Broken Hearts" – 4:36
 "24 Hour Charleston" – 2:39
 "Milky Drops from Heaven" – 4:44
 "Tehellet" – 3:40

Personnel
Adapted from the liner notes.

 Jonny Greenwood - piano, ondes Martenot, guitar, banjo, production

 Graeme Stuart - production, recording
 Shin Katan - artwork
 Stanley Donwood - artwork
 Julian Arguelles - saxophone (tracks 9,12)
 Gerard Presencer - trumpet (tracks 9, 12)
 Colin Greenwood - bass guitar, programming (track 11)
 Jeremy Brown - bass guitar (tracks 9, 12)
 Gene Calderazzo - drums (tracks 9, 12)
 The Emperor Quartet - strings (tracks 4, 10, 13)
Martin Burgess - violin
Violin: Clare Hayes
Viola: Fiona Bonds
Cello: William Schofeld

See also
 Music from The Body

References

External links

Jonny Greenwood albums
2003 soundtrack albums
Capitol Records soundtracks
EMI Records soundtracks
Parlophone soundtracks
Instrumental soundtracks
Documentary film soundtracks


text:
Klagenfurt am Wörthersee (slovinsky a česky Celovec, do roku 2008 zkráceně jen Klagenfurt), je statutární město a zároveň hlavní a největší město rakouské spolkové země Korutany, 235 km jihozápadně od Vídně, 100 km jihozápadně od Štýrského Hradce a 20 km severně od hranic se Slovinskem. Leží na řece Glan u jezera Wörthersee, v nadmořské výšce 446 m. Žije zde  obyvatel a je tak 6. největším rakouským městem.

Pamětihodnosti
 Katedrála svatého Petra a Pavla byla postavena v roce 1581 původně jako protestantská modlitebna zasvěcená Nejsvětější Trojici. Byla největším protestantským kostelem v Rakousku. V roce 1600 byl během protireformace uzavřen a o čtyři roky později předán jezuitům, kteří jej zasvětili svatému Petru a Pavlu. Jezuitům patřil do roku 1773, kdy byl řád zrušen. V roce 1787 biskup povýšil kostel na katedrálu gurské diecéze.
 Cisterciácký klášter Viktring z roku 1142. Působil zde Jan z Viktringu, sekretář českého krále Jindřicha Korutanského. Za josefínských reforem byl klášter v roce 1786 zrušen, později sloužil jako textilní továrna a od roku 1976 je zde gymnázium.
 Minimundus je park u jezera Wörthersee o rozloze 26 000 m², ve kterém je 159 modelů známých staveb, lodí a vlaků v měřítku 1:25. Byl otevřen v roce 1958 a výtěžek ze vstupného je určen pro potřebné děti v Rakousku.

Sport
Ve městě hraje veliké množství hokejových klubů. Mezi nejznámější patří EC KAC. Fotbalový stadion Hypo-Arena o kapacitě 32 000 diváků byl v roce 2008 jedním z hostitelských stadionů Mistrovství Evropy ve fotbale.

Politika

Starostové od roku 1850

Od roku 1991 jsou starostové voleni přímo.

Osobnosti

Rodáci
 Jan z Viktringu (1270–1347), historiograf
 Maximilian Daublebsky von Sterneck (1829–1897), velitel rakousko-uherského námořnictva
 Jožef Stefan (1835–1893), matematik a fyzik
 Robert Musil (1880–1942), spisovatel
 Ingeborg Bachmannová (1926–1973), spisovatelka
 Udo Jürgens (1934–2014), skladatel a zpěvák
 Dagmar Kollerová (* 1939), zpěvačka, tanečnice a herečka
 Penny McLean (* 1946), zpěvačka
 Sissy Höffererová (* 1953), herečka
 Monika Czerninová (* 1965), spisovatelka, dokumentaristka a herečka, potomek českého rodu Černínů z Chudenic
 Ursula Plassniková (* 1956), politička a diplomatka
 Karl-Heinz Grasser (* 1969), ministr financí Rakouska
 Stephanie Grafová (* 1973), lehká atletka
 Sabine Eggerová (* 1977), lyžařka
 Stefan Koubek (* 1977), tenista
 Thomas Pöck (* 1981), hokejista

Další známí obyvatelé
 Alois Beer (1840–1916), c. a k. dvorní a námořní fotograf
 Anton Martin Slomšek (1800–1862), spirituál klagenfurtského semináře a pozdější biskup v Mariboru
 Alois Melezínek (1932–2015), profesor a zakladatel inženýrské pedagogiky

Partnerská města

Reference

Externí odkazy

Okresní města v Rakousku
Obce v Korutanech
Drak ve znaku


text:
Q: Proof of Snell's law Snell's law states that $n_1 \sin i = n_2 \sin r$ where $i$ is the angle of incidence, $r$ is the angle of incidence and the refractive index, $n = \frac{c}{v}$ where $v$ is the velocity of the light ray in the given medium.
I wonder how the $\sin$ comes into play and how one would derive it as I was only taught the formula and not the derivation in school. I welcome multiple proofs because I really want to understand why Snell's law works from multiple angles.

redpajama_set_name: RedPajamaStackExchange


Many of Milwaukee's youngest offenders have for years been sent more than 200 miles away to pay for their crimes.
After years of revelations about inmate abuse at Wisconsin's youth prison, and the decision by state lawmakers to shut down the facility, there's little disagreement about bringing Milwaukee's youngest offenders closer to home.
But deciding where to house them has been anything but easy.
State officials are expected to open two prisons for young people in southeastern Wisconsin, including one in Milwaukee.
Milwaukee County officials independently reviewed dozens of locations and have since focused on two possible sites as the future home for a county-run facility to house youths who have committed less-serious crimes.
Both the state and county are considering sites in the 9th Aldermanic District on the city's northwest side.
Ald. Chantia Lewis, who represents the district, held a community meeting last month about the proposed state and county facilities. More than 100 people showed up, many worried that the plans could hurt local businesses, such as Direct Supply and the Phongsavan Asian Market.
Lewis is now calling for a "collaborative conversation" involving state, county and city officials, as well as residents, where all the potential locations could be discussed.
"We absolutely need to bring our children home," Lewis told the Milwaukee Journal Sentinel last week. "But we have to find the best location to do that."
Mayor Tom Barrett has also raised concerns about some of the proposed locations but insists that he doesn't want people to lose sight of the ultimate goal: Getting Milwaukee's youngest offenders out of Lincoln Hills School for Boys and Copper Lake School for Girls.
"We're moving the state facility (more than 200) miles, to the new county facility here," Barrett said. "I think it would be a mistake if we allowed the final two miles to become the problem."
Lewis said she learned of the proposals to build state and county facilities in her district secondhand late last year.
"It's unfortunate that we have been, as the city, kind of left out of that conversation," she said. "We need to, moving forward, all be able to come to the table."
She largely blamed the administration of former Gov. Scott Walker for failing to communicate with city officials.
The new tension comes three years after city and county officials said they would try to bring Milwaukee-area offenders closer to home after learning guards at the Irma youth prison were accused of keeping inmates locked in solitary confinement for weeks at a time, using pepper spray to manage behavior and causing serious injuries in some cases.
More than 50 young people from Milwaukee are still there. And local officials are still trying to bring them home, in part prompted by a new state law aimed at overhauling the state's juvenile corrections system.
Even if the closure of Lincoln Hills and Copper Lake is delayed at the state level, county officials say they don't want to slow down. And moving Milwaukee's teens is not dependent on the state's timeline for closing the youth prisons.
"We need to keep things moving," Mary Jo Meyers, director of the Milwaukee County Department of Health and Human Services, said at a recent juvenile justice meeting. "Every obstacle that comes in our way is one more day in which our children are far away from Milwaukee County, and from their homes and families in the city."
The Milwaukee County Board declared a state of emergency in 2016 over the well-being of the county's incarcerated teenagers. That move came after Milwaukee County Chief Judge Maxine White persuaded the board to approve a resolution to send a team to the youth prisons to begin transition plans to move the juvenile offenders out.
But concerns quickly grew that Milwaukee didn't have enough space in its existing local facilities to treat juvenile offenders, even as disturbing reports of conditions at the youth prisons continued.
Now Milwaukee County officials say they have waited too long already and are moving forward with their plans, which include submitting a grant proposal to the state by the end of March.
The county considered more than 40 different locations based on a variety of criteria, such as whether sites are close to bus lines and have at least 5.5 acres of land to allow for green space, Meyers said.
Other factors include environmental safety of the sites and proximity to inmates' families.
The county has since narrowed it down to two possible locations — one at 6101 W. Mill Road and another at 6600 N. Teutonia Ave. The latter is near the Milwaukee Safety Academy, where police recruits are trained.
Those properties are owned by the City of Milwaukee, and city officials would need to approve the purchase and rezoning of either site.
A third location, at 7301 W. Mill Road, has been discussed as the future home of a state-run facility for juvenile offenders who have committed more serious crimes. That site is a Division of Motor Vehicles office.
Both of the Mill Road locations are in Lewis' aldermanic district.
Barrett said he believes the Teutonia Avenue location would work best for the state-run facility and wants to find another site for the county-run center.
"For the county one, it's important to look at some alternatives," Barrett said.
State legislators last year agreed to close Lincoln Hills and Copper Lake by Jan. 1, 2021. That decision came after multiple lawsuits targeting the prison, as well as a federal investigation that began four years ago.
Gov. Tony Evers last week proposed indefinitely delaying the closure of the teen prison until new local facilities are up and running. Legislators from both parties have said they are open to extending the deadline to the summer or fall of 2021, but they have resisted delaying it longer than that.
County officials don't want to wait.
"If we don't get this right, if we don't get this right in a timely way, then our kids stay in longer," Meyers said. "And that is not OK with us."
The county's new center would aim to address issues around trauma and mental illness. It would also encourage family involvement and offer education and vocational training programs.
County officials also plan to work with community and nonprofit organizations to connect youths and their families with resources close to home in an effort to prevent the teens from committing crimes once they are released.
"The way that you respond to the most troubled kids is with your best effort," Tom Woods, a senior associate at the Annie E. Casey Foundation, told local officials at a recent juvenile justice meeting.
Woods also said creating "a place where kids report that they feel safe" and believe they're being treated fairly has been found to help with children's educational progress and success once they leave the center.
He added that feeling connected to staff, peers and family, and having a sense of purpose is also especially important for children in residential programs.
Milwaukee County Executive Chris Abele said he hopes Milwaukee can set a "new model" for the country.
"We want to get these kids' lives back on track," he said. "We want to get the society in Milwaukee to have the broad buy-in all societies should have — that we never give up on anyone. That everyone has potential."
Abele added that he believes the changes will save money and improve public safety, in addition to being the "morally right" thing to do.
Milwaukee Common Council President Ashanti Hamilton said he supports juvenile criminal justice reform but wants to make sure people citywide are participating in discussions about where new facilities will be built.
"This is a responsibility that we have citywide, and we should not put the burden of trying to make room for these facilities in one neighborhood," he said. "There has to be a balance with how we implement this, and we need to do it the right way."
The proposed Teutonia location is in the city's 1st Aldermanic District, which Hamilton represents. He said he wants to talk more with people in the community before deciding whether he supports a facility being built there.".
"I think the county is going about it the right way. They're having discussions in different areas of the city, they're getting engaged in the neighborhoods," Hamilton said. "Sometimes the process is just as important as how they run the facility."


text:
HOW DID MR. SMOKEY FRANCHISE?
Mr. Smokey was founded in January of 2019 when we opened our first retail store in Hialeah, Florida. The company found immediate success and opened three more locations throughout the year.
Our goal is to be the best premium Smoke Shop with the highest quality of products and an excellent customer service.
Our inventory includes the largest selection of disposables, hand-blown glass, cigars, premium vaporizers, hookah, shisha, hemp products, CBD, as well as all the smoking and vape related accessories you may need. If we don't carry it, we will order it for our customer's next time.
OUR TARGET MARKET
There is no denying the statistics that the demand for Smoke Shops is significant.
One Stop Smoke Shops are beginning to proliferate around the country. The Head Shop industry is growing into a $15 billion industry this year, with an average growth rate of 8.1 percent, according to Ibis World research.
There is a broad following in this industry that ranges from the age demographic of 18-50 years old. Young and old this industry aims at the masses. Below you will find some statistics for past years industry trends.
Mr. Smokey is leading the smoke and electronic cigarette retail industry. With locations currently throughout South Florida, we are looking to expand through the United States. We offer a full turnkey operation to get your store opened with inventory and ready for business.
If you are interested in joining our team and want to learn more about our franchise opportunity, please fill out the franchise form and a member of our team will contact you within 24 hours.
Year Company Founded: 2019
Year Started Franchising: 2022
Current Franchises
What type of franchise is available?
Mr. Smokey is offering single franchises and area development agreements for the operation of single or multiple retail locations within an exclusive territory.
How much does my franchise cost?
The total estimated initial investment for a Vape and Smoke Shop single franchise ranges from $90k – $200k which includes an initial franchise fee of $19,900. This initial franchise fee covers the cost of training, opening assistance, operations manual and other support and franchise development services.
Is there royalty or an on-going fee?
Yes, the continuing services or "royalty" fee is 7% of the monthly gross revenues derived from the franchised business. This fee entitles you to continued use of the Mr. Smokey Smoke Shop name & trademarks, and access to our unmatched franchisee support/benefit system which includes initial and on-going trainings, proven operating system, marketing assistance, group buying resulting in low product costs, and other benefits that come with being a part of the Vape and Smoke Shop community of franchises.
What about financials?
The Tables below represent the actual unaudited Profit and Loss statement for 3 of our Affiliate stores that have been open for at least 1 year. The Affiliate stores, while not franchisees, operate substantially the same business as that of franchisees herein would operate. There are several factors that are unique to the Affiliate's business that may be different from the business of a franchisee herein. The Affiliate has 5 locations located in Miami, Florida. The rental market conditions in Miami, Florida are highly competitive with some of the highest rents in the United States. Our Affiliate, Mr. Smokey Corp., are all located in areas having an extreme amount of foot traffic. Rents in these areas vary, but are approximately $20 – $55 per sq. ft. The population of Miami, Florida which is the 44th most populated which has an estimated 430,332 residents. The median income for the market is $46,946 for Miami, Florida. The gross number from the Profit & Loss Table are earnings before interest, taxes, and amortization (EBITA) which refers to a company's earnings before the deduction of interest, taxes, and amortization expenses. Again, we encourage you to consult with your own accounting, business, and legal advisors.
What about advertising?
We realize that furthering the recognition of Mr. Smokey Smoke Shop brand and reputation is essential in the success of our franchisees. A collective advertising budget allows us to advertise in media outlets that benefit us all. While we have not activated it at this time, we may require a contribution of up to 1% of your monthly gross sales in the future for a national marketing fund. You are also required to spend at least 2% of your monthly gross sales on local advertising.
What training is provided?
Mr. Smokey Smoke Shop provides you with a comprehensive and multi-faceted training course. You and up to three addition people may attend training. The training program is comprised of 20 hours of classroom training; 20 hours of on-the-job training; 2-days of onsite opening assistance (we come to you); and refresher courses are offered throughout the year.
What kind of continued support will I receive?
As a Mr. Smokey Smoke Shop franchisee, you are in constant contact with your franchise representative that will provide you with continued guidance with customer service, operations, accounting, marketing, and any other questions that may arise.
Will I have exclusive territory?
Yes, each Mr. Smokey franchisee will be given their own "designated zone" in which no other Mr. Smokey Smoke Shop locations will be allowed to operate. The exclusive territory will be a radius of 5 miles around your store or a population density of 50,000 people whichever is lesser.
What are the terms of the Mr. Smokey Smoke Shop Franchise agreement?
The term of the Vape and Smoke Shop franchise agreement is 15 years, followed by two consecutive renewable terms of 5 years each. The renewal fee at the time of each renewal is 25% of the current franchise fee.
What's my next step?
Please feel free to call us at (786) 202 5087 or email us at [email protected]
We have multiple stores.
4334 SW 8th Street Coral Gables, FL 33134
3182 W 76th Street Hialeah, FL 33018
3300 E 4th Ave Hialeah, FL 33013
We carry the largest selection of disposables, vapes, hand-blown glass, cigars, shisha tobacco and any vape or smoking related accessories.
If you want to tell us something, we are here and we love to chat!
So, please contact!

redpajama_set_name: RedPajamaCommonCrawl


A simple course that can be followed online from anywhere at a cost that is accessible to everyone.
WHAT IS THE MASTER IN NATUROPATHY AND TO WHOM IS IT ADDRESSED?
The MASTER IN NATUROPATHY online course can be carried out between a minimum of 20 days and a maximum of 10 months In your own time and at your own pace; you will then receive a certificate as Basic Practitioner in Naturopathy, only and after having submitted a short thesis that has been approved and reviewed with a positive mark. Always keep in mind that the modules studied and the chosen topics address the student to a holistic approach to health and has nothing to do with medical prescriptions or substitutions. The Basic Practitioner in Natuopathy does not and must not replace the doctor or the psychologist but is a figure of fundamental help.
Styleoga® is an international registered trademark, hence a very interesting private guarantee that allows you to have the right training and knowledge to start your profession as a Naturopathic practitioner. To have access to this course just apply by simply clicking on the paypal button below and send an email with a short curriculum to: styleoga1@gmail.com. The candidate will than be contacted and given all the necessary information. The total cost for this course including the necessary material and the final certificate (via email) is 490€ or 435GBP instead of the usual price of 690€/610GBP, therefore with no additional or hidden fees. In order to obtain the certificate, it is necessary to present (not before 20 days from the application and receipt of all the material) a mini thesis with an argument concerning the course, that will be assesed by the commission of the School of Naturopathy of styleoga®.


text:
Neal Notes - Home
Selfies: Evolving Technology May Be a Boon for Business
Neal Leavitt
The technology is sublimely simple – with a smartphone or webcam, take a self-portrait, upload it to a social media website. Have a drink, read a book, watch some TV, in short, let the 'selfie' percolate and if it's interesting/compelling, or just flat out weird, it'll probably go viral.
The 'selfie' phenomenon has grown exponentially. BGR, for instance, estimates more than 250 billion selfies will be taken worldwide this year.
People from all walks of life have embraced selfies. In fact, The Guardian reports that UK farmers are posting 'felfies' – a selfie snapped on the farm.
"But it's not just for fun – social media is a lifeline for people in a lonely profession…the 'felfie' is taking off, with farmers posting photos of themselves next to their favorite sheep, cow or tractor," noted The Guardian.
Off the farm, businesses are also finding innovative ways to utilize and market the selfie.
Squadrone System, a Palo Alto startup, has created HEXO+, an aerial drone enabling people to record footage of themselves. Headline & Global News (HNGN) reported that the semi-autonomous drone is being marketed to extreme sports athletes who want to film their stunts from a bird's eye view.
The helicopter-based drone, noted HNGN, accomplishes its maneuverability by predicting a user's movements and adapting to situations for optimum filming "with the help of anticipatory algorithms and a protocol called MAVLink that communicates with a user's Android or iOS smartphone."
HNGN added that users operate the drone via the included app to define the filming perspective and adjust the height, angle and distance. After receiving the settings, the drone takes off automatically, hovers in its position and waits for users to move. Then it moves along with them, automatically maintaining framing. The machine also tracks GPS coordinates on the phone to determine where users are at all times.
A couple hours north of Palo Alto in Sacramento, yet another startup, iSnap, is using photo kiosks to help businesses boost their social marketing skills. iSnap has 450 photo stations in seven countries; photos generated from this network currently exceed 1.5 million.
With iSnap, you take a picture, upload it instantly to Facebook or Twitter for free – a cell phone isn't needed to post the selfie. Businesses like the Esquire IMAX Theater in downtown Sacramento buy the kiosk, noted News10 (ABC News affiliate in Sacramento).
"What they get in return are branded photos shared online in real time and access to their customers emails and social networks," said News10.
And a suite of iSnap analytics software allows a business to track everything happening in its venue. As reported on the iSnap blog, this is everything "from data capture to running promotions via third party APIs and demographic insight. For instance, small restaurants, doctors and family entertainment centers use the products to deliver coupons and specials."
iSnap says its technology can help businesses in a wide variety of ways. One example - capturing new Twitter followers on the photo station.
There have also been numerous creative uses of the selfie by companies.
#MuseumSelfie day – Held on Jan. 22, this was a Twitter project that raised awareness of great collections housed by national and regional museums worldwide. The initiative generated thousands of artistic images, with the goal of encouraging people to support and visit museums.
Last year, AMC introduced a branded camera app called Dead Yourself to help promote The Walking Dead TV series. Sparksheet reported that fans could 'zombify' their selfie picture and share online via the hashtag #deadyourself.
The app also included a 'Bite Your Friend' feature, added Sparksheet, which "let users turn a friend's selfie into a photorealistic zombie. It also included a gamified element – contestants can upload their self-portraits for the chance to have them shown on TV."
The promotion was wildly popular – the app was downloaded 3 million times; 100 million+ photos were viewed in the app.
Lastly, Johnson & Johnson launched in 2013 a 'Selfless Selfie' campaign – participants were asked to subscribe to the company's Donate a Photo app. For every photo uploaded, Johnson & Johnson contributed a buck towards a charity of the user's choice.
Selfies are undoubtedly self-centered – no sh_t, Sherlock - that's why they're called that. But properly implemented, they're fast becoming yet another tech tool for businesses to generate product buzz and help drive sales.
Car Hacking: How Safe Are You Behind the Wheel in Today's Digital Society?
BLOG POST: The complexity of today's cars is staggering – being mechanically inclined doesn't cut it these days – you have to be a bit of a computer whiz too in order to service new model cars.
CES a Showcase for Offbeat Gadgets
BLOG POST: This marked my 10th consecutive year at International CES, and as regular as the day's sunset, there will always be on display various gadgets that make you scratch your head and wonder what the inventors were thinking. And with others, you still scratch your head as well and think – what a clever idea! Why didn't I think of that?
Drones Poised for Commercial Takeoff
BLOG POST: Unless you're completely cut off from civilization (in which case you wouldn't be reading this), drones are rapidly buzzzzzzzing their way into our lives. And the global market and impact is enormous. The Consumer Electronics Association, for instance, estimates about 425,000 drones will be sold this year, amounting to about $130 million in sales. By 2018, the annual market is expected to top $1 billion.
Internet of Things Upending Manufacturing
ARTICLE: In a report issued last year by PWC, "The Internet of Things" What It Means for US Manufacturing," the company said "over the next decade, manufacturers could stand to capture about $4 trillion of value from the IoT through increased revenues and lower costs." That's a lot of pocket change.
Is It Time Now for Smart Guns?
ARTICLE: The tragic Charleston shooting last week has again brought the national conversation about gun control front and center. Concurrent with that has been a lot of Internet chatter about smart gun technology.
Shooting the Messenger: Anti-Drone Defense Systems Becoming Big Business
ARTICLE: Pundits for the past year or so have been lauding about the wonderful things that drones will do for us – now we're trying to figure out how to shoot 'em all down.
Mobile Ad Revenues Steadily Increasing but Challenges Abound
Monday, Aug 31, 2015
ARTICLE: Advertisers have been salivating for years at the promise of mobile advertising. Gartner, for instance, predicts that by 2017, annual mobile advertising revenues will be almost $42 billion. Display formats making up most of that chunk, but video (driven by tablets and growth in tablet ownership) will show the highest growth.
Farmers Embracing Technology to Improve Agriculture
ARTICLE: Tractor cabs that look like airplane cockpits. Cow heat detection devices. Crop-monitoring drones. Robot milking machines. Sensors that continuously measure everything from nitrogen content to livestock biometrics.
Keep on Truckin' – Mobile Apps Moving on Down the Road
ARTICLE: Over the past couple of years, according to Fleet Owner, truckers have tapped in to an array of mobile business applications that are helping to strengthen a fleet's competitive advantage and assist with regulatory compliance.
Will Robo-Advisors Invade the Financial World?
Monday, Nov 30, 2015
ARTICLE: While it's not likely that R2-D2 is going to sit down with you at home and help construct your portfolio, reinvest your dividends and even harvest your tax losses, the use of robo-advisers is nonetheless growing in popularity.
Advances in Affective Computing Expected to be Game Changers in Many Verticals
ARTICLE: Affective computing is nothing new – it has been around for awhile – over a decade, in fact. As defined by MIT's Media Lab, affective computing is computing "that relates to, arises from, or deliberately influences emotion or other affective phenomena."
Telematics On Cusp of Widespread Adoption
ARTICLE: Telematics is nothing new – the technology's been around for decades – but the ubiquitous smartphone is now expected to drive telematics penetration in private hire vehicles and taxis to 21% globally by 2019
Biometrics Making Inroads with Financial Institutions
Wednesday, Mar 30, 2016
ARTICLE: While numerous financial institutions worldwide have embraced biometric technology, widespread acceptance and adoption by customers is still in its early stages.
Technology's Making Smart Clothing Even Smarter
Monday, Apr 25, 2016
ARTICLE: A generation from now (or probably much less), your blue jeans might tell you that they really need to be washed. Or your blue blazer might complain that that hideous Christmas gift tie you got from Aunt Mabel just doesn't cut it with your dress shirt and slacks.
Got Game? Analytics May Help Those Weekend Duffers
Wednesday, Jun 1, 2016
ARTICLE: If you constantly shank your drives into the rough, have a propensity for landing your ball in every other sand trap and have a knack for choking on those three-foot putts, well, golf analytics may offer some incremental improvements to your game, but playing on the PGA Tour will still be a bedtime fantasy. The skinny, however, is that the analytics gleaned via wearable technology and cloud computing are bringing about a sea change in golf.
Driverless Cars Are Coming – a Paradigm Shift
Thursday, Jun 30, 2016
BLOG POST: An MIT study predicted last year that shared, self-driving cars may take so many vehicles off the road – perhaps 80% of them – that a new class of 'exurbs' in the U.S. may spring up within a decade. "With fewer cars, much of this space could be freed for other uses. Such reduction in car numbers would also dramatically lower the cost (and related energy consumption) of building and maintaining roads," said MIT's Matthew Claudel and Carlo Ratti. One engineering study, they noted, found that automation could quadruple capacity on any given highway – and fewer cars translate to less noise and a small environmental impact. These self-driving vehicles will eventually blur the lines between public/private transportation modes.
Smart Appliances Are on the Rise
Friday, Jul 29, 2016
BLOG POST: Washers of the world, unite! While that's taking a bit of poetic license from the famous rallying cry in the 1848 Communist Manifesto by Karl Marx and Friedrich Engels, advances in smart appliances may someday have washers from Halifax to Harare talking to each other.
Digital Trading Cards Growing in Popularity – Bubble Gum Not Included
Thursday, Aug 25, 2016
BLOG POST: I never threw out my extensive baseball card collection. While I don't have a T206 Honus Wagner American Tobacco Company card (sold for $2.8 million in August 2007) or a Topps 1952 Mickey Mantle rookie year card (sold by Dallas-based Heritage Auctions in December 2015 to an anonymous collector for $525,800), the collection has increased in value over the years as it sits in multiple shoe boxes silently stuffed away in a corner of a closet. Not surprisingly, in today's digital age, sports card collecting has also gone digital over the past few years and those of us that still have paper card collections are becoming an endangered species. You no longer get a stick of Bazooka bubble gum to chew for hours on end, but the flip side is that a memorable sports moment can immediately be available online and downloaded.
Warehouse Robots Boosting Productivity – and They Don't Call in Sick
BLOG POST: hey never take a vacation day. In fact, they work 24/7 in the warehouse with nary a complaint. They don't kvetch about the rising cost of healthcare insurance. And other than initially programming them, they don't need any extensive training. Warehouse robots are growing in popularity and are already causing an upheaval in the industry. Steve Vairma, who heads up the International Brotherhood of Teamsters, which represents 122,000 grocery-warehouse workers, said "employers are looking to move more and more into automation and we're going to be faced with those challenges in contract negotiations in coming years."
Millennials Discovering, Buying New Works of Art Online
BLOG POST: It should come as no surprise - Millennials grab most of their info online – and via smartphones. And that extends to how they discover works of art. To further corroborate this, Invaluable, an online marketplace for fine art, antiques and collectibles, conducted a survey earlier this year entitled 'American Attitudes Toward Art.' Some interesting survey findings:
Useful Gadgets, Wacky Gizmos; Par for CES
BLOG POST: This year at CES marked a personal milestone – the good folks at CES affixed a '10+ Years' ribbon to the bottom of my badge (it's actually 12 but who's counting). To paraphrase from those ubiquitous Allstate commercials, after a dozen consecutive Las Vegas sojourns, "I know a thing or two because I've seen a thing or two." And there was a lot to see. The buzzwords this year were augmented reality, virtual reality, artificial intelligence, and robotics. Wearables and phones? There, but somewhat passé. On to the next trend(s), product(s).
Surprising Marketing Lessons from the Pet Industry
Friday, Feb 3, 2017
BLOG POST: Marketers can learn a thing or two from our furry (and scaly for those who may own reptiles, snakes, other creepy-crawlers) friends. While the fast-growing $61 billion a year pet product industry is wooing new consumers with disruptive marketing campaigns, e-Commerce and digital marketing to pet owners is still the new frontier. According to Annalect, a New York City-based data analytics company, only 8.2 percent of the entire market regularly shops for pet products online.
AI Helping Marketers Better Engage Customers
Tuesday, Apr 25, 2017
BLOG POST: Artificial intelligence (AI), to use a hackneyed term, is already causing a paradigm shift for marketers. AI, in brief, is helping brands to rapidly collaborate with and learn from online followers. And while there probably exists many a Luddite that deems AI a pervasive jobs threat, the flip side is that it may be a golden opportunity to let the machines do mundane stuff like customer support, enabling humans to become more creative.
Ahoy! Crewless Ships are Just Over the Horizon
Friday, Aug 11, 2017
BLOG POST: Arghhh! To use some parlance from any of the 'Pirates of the Caribbean' movies, in the next few years, that's how some naysayers may react once they see crewless ships on the high seas.
Technology Helping Firefighters Tackle Wildfires
Tuesday, Jan 2, 2018
BLOG POST: How is technology giving firefighters an extra edge? With the Lilac Fire, helicopters carried iPads that displayed critical information; the firefighters also had custom cell phone apps that gave them up-to-the-second status reports.
MOBILE - Prime Time for Wearable Devices?
Tuesday, Feb 18, 2014
BLOGPOST: Welcome to NealNotes; this is my inaugural blog post. Not exactly Proustian prose, but there you have it – short/succinct. Going forward, I'll comment on various technology trends/issues/ideas, in short, whatever techles my fancy (sorry, inveterate punster too, even when borderline like that one). Unless you have successfully disengaged yourself from every conceivable 21st Century communications device, you've probably been hearing a lot about wearable devices – that they're the next big trend/revolution/most stupendous technological invention since the cotton gin, ad nauseum. Well, not quite, but wearable devices were yakked about incessantly at CES 2014 last month and the overall buzz is getting louder.
MOBILE - Internet of Things Evolving Into a Game Changer
BLOGPOST: Unless you're completely off the technology grid (and in which case, you wouldn't be reading this post anyhow), you've probably been bombarded by countless stories/mentions about the Internet of Things (IoT). Whether you're aware of it – like it or not – the IoT is already transforming our lives. Procter & Gamble, for instance, rolled out a web-enabled toothbrush at last month's Mobile World Congress in Barcelona. It links with your smartphone, records your brushing habits and even has an app providing mouth-care tips alongside news headlines.
NETWORKING - Getting Help from the Home Country Proving Essential for Foreign Startups in the U.S.
Friday, Apr 18, 2014
BLOGPOST: It's challenging enough trying to generate some noise and buzz about your product/service/app if you're a U.S.-based startup. Cracking the U.S. market can be daunting. But if you're a foreign startup, the difficulties are manifold. Fortunately, many countries and private organizations have realized this and have rolled out extensive programs and services to bolster the success rate for these nascent companies on this side of the pond.
Israeli Semiconductor Industry Continues to Thrive, but Some Clouds May Be on Horizon
BLOGPOST: Back in 1974, Dov Frohman, one of Intel's first employees and the inventor of EPROM, erasable programmable read only memory, decided to leave Silicon Valley and return to Israel, his adopted home since 1949. Frohman was charged with helping Intel establish a small chip design center in Haifa, which at the time, was Intel's first outside the U.S. The rest, as the cliché goes, is history. In a little over a generation, the Israeli semiconductor industry has grown to now employ more than 20,000; annual revenues are about US $5 billion.
MOBILE - Selfies: Evolving Technology May Be a Boon for Business
Wednesday, Jun 25, 2014
PODCAST: The 'selfie' phenomenon has grown exponentially. BGR, for instance, estimates more than 250 billion selfies will be taken worldwide this year. People from all walks of life have embraced selfies. In fact, The Guardian reports that UK farmers are posting 'felfies' – a selfie snapped on the farm. "But it's not just for fun – social media is a lifeline for people in a lonely profession…the 'felfie' is taking off, with farmers posting photos of themselves next to their favorite sheep, cow or tractor," noted The Guardian.
Organ-on-a-Chip Could Aid Drug Discovery, Be the Shape of Medicine to Come
PODCAST: Culturing 3D human tissue on a microchip isn't new. Like system-on-a-chip (SoC), which shoehorns most of a digital computer into a single chip, an organ-on-a-chip is designed to replicate human organ functions (including activities and mechanics like blood and oxygen flow) on a transparent, flexible microchip. These microfluidic devices which, in effect, are 3D cell culture versions of real organs, already exist for artery, cartilage, gut, heart, kidney, and skin.
3D Printing Opening the Doors to Counterfeiters
Monday, Sep 1, 2014
BLOGPOST: Last year architects in Amsterdam started constructing a 3D printed home. Aircraft manufacturers are honing ways to build 3D printed planes. And 3D printing is now wending its way through the fashion industry. A 3D printed dress designed by Michael Schmidt (designed on an iPad), was printed for a private runway event – it was printed in 17 parts on an EOS P350 3D printer. "3D printing presents tremendous opportunities for businesses," said Simon Jones, a partner at DLA Piper in London, a global law firm. "Manufacturers will no longer need to own large production facilities halfway around the world, because they can print products on demand or sell licenses to print them locally. This will have a huge impact on the supply chain; it will benefit the environment as there will be less waste, and companies will no longer need to spend a fortune gearing up to make a product and hoping its stock sells." So the sky's the limit for 3D printing. And for counterfeiters too.
NETWORKING - Smart Cities: The Future Is Now
BLOGPOST: With the world's population now exceeding seven billion, many municipalities in both emerging markets and developed nations are paying closer attention on how they manage their infrastructure and resources. A number of larger cities are well on their way to becoming smart cities. Market research firm Frost & Sullivan succinctly sums up how these cities are now being defined – built on solutions and technology leading to the adoption of at least five of eight smart parameters – smart energy, smart building, smart mobility, smart healthcare, smart infrastructure, smart technology, smart governance and smart education, and smart citizen.
INSIGHTS - Classroom Technology Changing the Way Kids – And Adults Learn
BLOGPOST: Textbook. 20th Century definition: A manual of instruction in any branch of study. 21st Century definition: Ancient learning methodology, last used by aging baby boomers. Killed lots of trees. Replaced by e-Books that are usually interactive and often open or free to use and sometimes edit.
MOBILE - High-Tech Ordering Becoming the Norm at Both Mainstream and Fast-Food Restaurants
Monday, Dec 1, 2014
BLOGPOST: It's probably not too far fetched now to predict that in the near future – at least within the next decade or so according to some studies and experts – you might be served by R2D2, or a similar robotic food service entity. Yes, numerous restaurants, especially those of the fast-food variety, are rapidly embracing
Big Data Trends: by David Feinleib
Excelsior College
Mind the Cloud: by Thoran Rodrigues
Musings from the Ivory Tower by Sorel Reisman
No Batteries Required: by Ray Kahn
Notes from the Expo Floor: by Brian Kirk
Out of Print: by Evan Butterfield
Rackspace Sponsored Content
Shay Going Mobile: by Shay Shmeltzer
Software Technologies: by Christof Ebert


Mythic Plus dungeons are now available! Completing a +10 will get you the highest item level loot for your weekly chest next reset! Blizzard has continued to build upon the Mythic Plus system for Battle for Azeroth, adding in some changes!
Battle for Azeroth Keystone Master: Season One.
These seasons will also feature seasonal affixes.
Weekly Mythic + chest can now contain up to 3 pieces of gear.


Reminder: Blog reader always note its one Blog post date ( we do not delete very old topics ).
If there will be a contest in the future of most advanced regarding design electrical breakout box, this one will win the first prize.
This is not a usual electrical breakout box, this one it does offer and a second functionality as active monitor of ups output.
This tool in combination with ITTSB Variac transformer project, it is one complete ups evaluation test bed.
As soon this gets ready I will add further explanatory text regarding combinations of usability.
This is my active project and today, estimated to be completed in few hours.
Due specific project box selection, there is one limitation speaking of easy to dismantle this box.
Therefore I took few pictures from the internals at 95% regarding wiring job.
Next wave of pictures will be very informative regarding features of this industrial grade electrical breakout box.
In summary this new combo of Variac transformer among with electrical breakout box, they are professional test bed this to serve in a large number of applications.
1) AC voltage control and loads up to 2100 VA.
2) Evaluation regarding accurate measurements of DMM, clamp on meter and Oscilloscopes and even of dedicated power analyzers.
3) Evaluation of ups (uninterruptible power supply) by simulating several electrical conditions.
4) Accurate and safe AC current measurements by the use of multimeter down to mA as assistance about evaluating (Low power consumption) power saving mode.
5) Evaluation of all sort of pulsing power supply (computers - laptops - mobile phone chargers), regarding correct operation at named minimum to maximum operating voltage range.
In seven days ITTSB Blog this enters in sixth year of operation, and I did use all experiences which I did collect in past five years, so me to design and make my very own and complete from every aspect testing compo.
I bet that this project will act also as awakening at influencing other people so them start reusing metal cases of non-worthy ups, for similar projects.


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text:
Year : 2019 | Volume : 15 | Issue : 3 | Page : 625--630
Impact of stromal CD45RO+ immune cells on proliferation and dedifferentiation in node-negative squamous cell carcinomas of cheek mucosa
Vijay Wadhwan1, Arvind Venkatesh2, Pooja Aggarwal1, Vandana Reddy1, Preeti Sharma1, Suhasini Gotur Palakshappa1,
1 Department of Oral Pathology and Microbiology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India
2 Consultant Oral and Maxillofacial Pathologist, Smile Square Multispeciality Dental Center, Karur, Tamil Nadu, India
Dr. Arvind Venkatesh
Smile Square Multispeciality Dental Center, 20/116, Dindigul Road, Karur - 639 001, Tamil Nadu
Background: The most fundamental trait of cancer cells involves their ability to sustain chronic proliferation. Tumors have a complex cellular ecology that establishes the malignant potential of the tumor. In these ecosystems, innate immune cells are highly represented. Many contradictory reports have been published regarding the impact of tumor-infiltrating immune cells on proliferation of the tumors. Aim: This study aims to assess the impact of CD45RO+ve immune cells on proliferation and dedifferentiation of node-negative squamous cell carcinomas of cheek mucosa (SCC-CM). Materials and Methods: Thirty formalin-fixed paraffin-embedded tissue blocks of previously diagnosed node-negative SCC-CM subclassified as Grade I SCC – 10 cases; Grade II SCC – 10 cases; and Grade III SCC – 10 cases (Broders' classification – 1927). Immunohistochemistry performed on each selected tissue section using anti-p53 and anti-CD45RO as primary antibodies. Semi-quantitative analyses performed for all the tissue sections to assess the p53 and CD45RO expression. p53:CD45RO expression ratio calculated. The data were statistically analyzed using GraphPad Prism 5 for Windows. Results: Our results showed statistically significant increase (P = 0.0006) in p53 expression and decrease (P = 0.0044) in CD45RO+ immune cell response with the decrease in differentiation of SCC-CMs using Fisher's exact test and statistically significant increase (P < 0.001) in p53:CD45RO expression ratio with decrease in differentiation using one-way ANOVA. Conclusion: Based on all these findings from the present study, we perceive the following findings. In node-negative SCC-CMs, CD45RO+ immune cells play a possible role in controlling the dedifferentiation of the tumor and in limiting the proliferative potential of the tumor cells which are tumor antagonistic in nature.
Wadhwan V, Venkatesh A, Aggarwal P, Reddy V, Sharma P, Palakshappa SG. Impact of stromal CD45RO+ immune cells on proliferation and dedifferentiation in node-negative squamous cell carcinomas of cheek mucosa.J Can Res Ther 2019;15:625-630
Wadhwan V, Venkatesh A, Aggarwal P, Reddy V, Sharma P, Palakshappa SG. Impact of stromal CD45RO+ immune cells on proliferation and dedifferentiation in node-negative squamous cell carcinomas of cheek mucosa. J Can Res Ther [serial online] 2019 [cited 2021 Jan 19 ];15:625-630
Available from: https://www.cancerjournal.net/text.asp?2019/15/3/625/243487
The biological capabilities acquired during the multistep development of human tumors are referred to as hallmarks of cancer.[1] They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, reprogramming of energy metabolism, and evading immune destruction.[1],[2]
The most fundamental trait of cancer cells involves their ability to sustain chronic proliferation. In addition, cancer cells must also circumvent powerful programs that negatively regulate cell proliferation; many of these programs depend on the actions of tumor suppressor genes.[3] One of the prototypical tumor suppressors encode the TP53 proteins; they operate as central control nodes within two key complementary cellular regulatory circuits that govern the decisions of cells to proliferate or, alternatively, activate senescence and apoptotic programs.[4]
Tumors have a complex cellular ecology that establishes the malignant potential of the tumor. In these ecosystems, innate immune cells are highly represented.[5] The stroma in human carcinomas consists of extracellular matrix and various types of noncarcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts, and bone marrow-derived progenitors.[6] Immune cells are represented by those of innate immunity, including macrophages, neutrophils, mast cells, myeloid-derived suppressor cells, dendritic cells and natural killer cells, and cells of adaptive immunity, such as T- and B-lymphocytes.[7] CD45 is known as the leukocyte common antigen. It functions as a tyrosine phosphatase in leukocyte signaling. CD45RO is a marker for memory cells – expressed when naive CD45 leukocyte antigen changes into an activated isoform.[8]
Many contradictory reports have been published regarding the impact of tumor-infiltrating immune cells on tumors. The primary reason for these contradictory observations and the molecular mechanism(s) for the reported diverse impacts, however, have not been elucidated.[9],[10],[11],[12] It has long been speculated that these contradictory reports may result from differences in tissue types and tumor stages, in which infiltrating immune cells are differently distributed and physically associated with different cell types.[13]
Hence, we intended to assess the impact of CD45RO+ve immune cells on proliferation and dedifferentiation of node-negative squamous cell carcinomas of cheek mucosa (SCC-CM).
After institutional review board approval, paraffin-embedded tissue blocks of 30 previously diagnosed cases of SCC-CM were retrieved from pathology archives. Fresh hematoxylin and eosin-stained sections were made of all the cases retrieved and histopathological interpretation was done by three qualified pathologists (V. W., P. A., and V. R.) to confirm the grading of SCC as per Broders' classification (1927). The final study material included Grade I SCC – 10 cases; Grade II SCC – 10 cases; and Grade III SCC – 10 cases. The following inclusion and exclusion criteria were considered during the selection of cases.
Histopathologically confirmed cases of squamous cell carcinomas (8070/3) of cheek mucosa (C 06.0)Cases with complete clinical history and TNM stagingAdequate availability of paraffin-embedded tissue blocks.
Patients with SCCs other than from cheek mucosaUnavailability of clinical or pathological TNM dataCases with positive nodes, perineural invasion, distant metastasis, and extracapsular spreadPatients suffering with other diseases such as blood dyscrasias, autoimmune, immunodeficiency diseases, or any systemic disease affecting normal immune responseAdministration of chemotherapy or radiotherapy before the biopsy procedure.
From each paraffin-embedded tissue block selected, consecutive serial sections of 3 μm thicknesses were made on two poly-l-lysine-coated slides. Sections were deparaffinized and rehydrated with xylene and serial dilutions of ethanol to distilled water. Tissue sections were immersed in 1× sodium citrate buffer at a pH of 6 and heat-induced epitome retrieval was done using autoclave method at 120°C; 12–15 psi for 15 min. For each sample, anti-p53 antibody (Biogenex, Fremont, USA, mouse IgG, ready to use) was used as primary antibody on tissue sections of one slide and anti-CD45RO antibody (Biogenex, Fremont, USA, mouse IgG, ready to use) on the other tissue sections for a 1-h incubation at room temperature in a humidity chamber. The antigen-antibody binding was detected with labeled antimouse polymer-HRP detection system and DAB + chromogen (Biogenex, Fremont, USA). Tissue sections were briefly immersed in hematoxylin for counterstaining. In all cases, staining of dysplastic epithelial cells served as positive internal controls for anti-p53 antibody and sections of tonsils with known antigenic potential were used as positive controls for anti-CD45RO antibody. For negative control, the primary antibody was replaced by mouse-negative control (nonimmune serum in phosphate-buffered saline with 0.09% sodium azide).
Semi-quantitative assessment and statistical analysis
The slides were initially analyzed at low magnification (×100) to select the areas to be included for semi-quantitative assessment [Figure 1]. p53 expression was analyzed in the cancer islands which were defined as cancer tissue without fibroblasts and vasculature. Five high-power fields (×400) were selected in tumor proper area and the percentage of immunoreactive dysplastic cells were categorized based on the scores as mentioned in [Table 1]. CD45RO expression was analyzed in the stroma which was defined as connective tissue surrounding cancer nests without any cancer cells. Five high-power fields (×400) surrounding the dysplastic islands assessed for p53 expression and based on the type or pattern of CD45RO positive immune cells in the stroma, a specific score was assigned as mentioned in [Table 2].{Figure 1}{Table 1}{Table 2}
p53 expression in squamous cell carcinomas of cheek mucosa
Various staining patterns were observed for p63 expression in SCC-CMs [Table 3]. It was observed that the pattern of staining differs between the grading of neoplasms. Grade I neoplasms showed a uniform staining pattern with the percentage of positive cells generally <50% (7/10) [Figure 2]a of the dysplastic epithelial cells in the stroma. Few (3/10) showed increased expression (50%–75%). Among Grade II neoplasms, the expression of p53 increased and most of the cases (7/10) showed >50% [Figure 3]a of p53-positive dysplastic epithelial cells. Grade III neoplasms showed highest percentage of expression with majority of the cases (9/10) showing the highest degree of p53 expression (>75%) [Figure 4]a. In both Grade II and III, the pattern of expression was more intense and diffuse compared to the Grade I counterparts. Staining for p53 was not detected in the keratin pearl areas. Hence, in SCC-CM, both low and high p53 percentage of positive cell could be appreciated by p53 immunolabeling, having more positive cells in less differentiated tumors than in highly differentiated ones.{Table 3}{Figure 2}{Figure 3}{Figure 4}
CD45RO expression in squamous cell carcinomas of cheek mucosa
Various staining patterns and types of distribution were observed in the CD45RO+ immune cells in the stroma [Table 4]. Similar to p53 expression, it was observed that there was a grade-dependent alteration in the pattern and intensity of CD45RO+ immune cells in the stroma. Grade I neoplasms showed mainly, dense pattern (continuous/discontinuous) (9/10) of CD45RO+ immune cells in the stroma [Figure 2]b. One case of Grade I neoplasm showed sparse CD45RO+ immune response. Grade II neoplasms showed a wide range of CD45RO+ immune expression with cases showing both dense (6/10) and diffuse [Figure 3]b or limited (4/10) patterns of immune response. Grade III neoplasms showed generally decreased immune response. All the cases (10/10) showed sparse (5/10) [Figure 4]b or limited (5/10) CD45RO+ immune response. Hence, in SCC-CM cases, dense, diffuse, and limited percentage of positive cells in the stroma could be detected by CD45RO immunolabeling, have more positive expression in well-differentiated tumors than the less differentiated ones.{Table 4}
p53:CD45RO expression score in squamous cell carcinomas of cheek mucosa
p53:CD45RO expression score was calculated across the groups [Table 5] which showed increase in the p53:CD45RO ratio from Grade I to Grade III neoplasms. Although overlapping ratios were observed between Grades I and II and II and III, the means of score ratio were ascending from Grade I (mean, x = 0.625) through Grade II (mean, x = 1.175) to Grade III (mean, x = 2.9) neoplasms. This is in consensus with the increase in p53 and decrease in CD45RO immunolabeling from highly differentiated to undifferentiated tumors.{Table 5}
Statistical Analysis and Results
The data were statistically analyzed using GraphPad Prism 5.03 for Windows (GraphPad Software Inc., La Jolla, CA, USA). A statistically significant correlation (P = 0.0006) has been found between p53 expression and the histological grading of the tumor when we evaluated the p53 expression and the grading of the tumor by Fisher exact test [Table 3]. In fact, the percentage of cells expressing p53 was lower in well-differentiated tumors with respect to undifferentiated ones.
Similarly, a statistically significant correlation (P = 0.0044) has been found between CD45RO expression and the histological grading of the tumor when we evaluated the CD45RO expression and the grading of tumor by Fisher exact test [Table 4]. In contrast with p53 expression, the density of CD45RO+ immune cell pattern was higher in well-differentiated tumors with respect to undifferentiated ones.
One-way ANOVA showed significant increase (<0.001) in the p53:CD45RO score ratio from Grade I to Grade III neoplasms [Table 5] and Tukey's multiple comparison posttest revealed statistically significant increase (P < 0.05) in the p53:CD45RO score ratio between SCC-CMs of Grades II–III and I–III.
In most studies performed, squamous cell carcinomas of head and neck (SCCHN) from all different subsites are included and results interpreted as valid for the whole group of SCCHN tumors. A study conducted by Boldrup et al.[14] showed a distinct difference between normal tissues from different subsites, emphasizing the fact that SCCHN comprises a heterogeneous group of tumors that should be analyzed based on subsite. Hence, in the present study, squamous cell carcinomas (8070/3) of cheek mucosa (C 06.0)[15] alone were included to avoid bias due to subsite.
A characteristic of cancer cells is its ability to undergo extensive proliferation through overproducing growth factors. The tumor suppressor gene (p53) is a negative regulator of cell cycle progression.[16] Various studies have shown positive correlation between p53 expression and degree of differentiation and proliferation of the tumor.[17],[18]
Pathological evidence has continually supported the prognostic value of tumor-infiltrating T-lymphocytes for several solid tumors across diverse patient cohorts. Numerous markers including CD3, CD4, CD8, CD16, CD45, CD68, CD134, and Tregs (CD4+Foxp3+)[19] have been employed alone and/or in combinations in literature to analyze the immune response in various tumors. However, T-cells expressing CD45RO, which is the most suitable single marker of human memory T-cells, have been demonstrated to play specific and significant roles in a number of human cancers such as colorectal cancer, gastric cancer, esophageal carcinoma, and ovarian and renal cell carcinoma.[20],[21],[22],[23],[24],[25],[26] Moreover, a meta-analysis conducted on this regard has showed that intratumor infiltration by CD45RO+ memory T-cells is a robust immunological indicator of a favorable survival time in cancer patients and that CD45RO is more sensitive than CD3 for categorizing patients, based on the clinical outcomes. The predictive significance of memory tumor-infiltrating lymphocytes (TILs) was reproducible among cohorts with diverse tumor types, regardless of the detailed characteristics of the patients.[27] Hence, CD45RO was our choice of immune cell marker in the present study.
Currently, there are two concepts regarding the search for carcinoma cells by the immune system. Immune surveillance is based on the specific identification of transformed and normal cells through their different antigenic determinants. The Erhlich–Thomas–Burnet theory of immune surveillance considers that the immune system protects against transformed cells carrying foreign, nonself signals, whereas the Grossman–Heberman theory proposes an antitumor surveillance system that regulates self-population of cells.[28],[29],[30]
Although the precise nature of the immune system's role in cancer has not been fully elucidated, we know that tumors are immunogenic and that cancer is caused by a variety of genetic defects that occur in genes that encode for proteins involved in cell growth.[31] The components of the immune system, antibodies, and T-cells do not recognize or respond to defective genes but recognize and respond to the abnormal proteins the cancer-causing genes encode. Thus, the individual components of the immune system play a major role in cancer.[32]
Various contrasting results have been obtained in studies conducted regarding the impact of tumor-infiltrating immune cells on tumors. On the one hand, certain studies have reported that direct physical contact between infiltrating immune cells and tumor cells is associated with the destruction of associated tumor cells, reduction of tumor size, and significantly improved clinical prognosis.[9],[10] On the other hand, a steadily increasing number of publications have shown that increased immune cell infiltration promotes tumor progression and invasion.[11],[12] It has long been speculated that these contradictory reports may result from differences in tissue types and tumor stages, in which infiltrating immune cells are differently distributed and physically associated with different cell types.[13]
From the present study, in addition to statistically significant increase (P = 0.0006) in p53 expression and decrease (P = 0.0044) in CD45RO+ immune cell response with the decrease in differentiation, certain interesting findings have also been discerned. The p53:CD45RO score ratio showed statistically significant (P < 0.001) increase in the ratio with decrease in differentiation.
Furthermore, when the study population was tabulated based on the p53 expression [Table 6], certain findings were evident.{Table 6}
Decrease in the mean CD45RO score with decrease in differentiation among cases with the same p53 scoreAmong cases of same grades, increase in the mean CD45RO score was appreciated with increase in the p53 scores.
Based on all these findings from the present study, we perceive the following findings. In node-negative SCC-CMs, CD45RO+ immune cells play a possible role in
Controlling the dedifferentiation of the tumorLimiting the proliferative potential of the tumor cells.
There are numerous complex mechanisms which are involved in generation and storage of tumor-specific immune cells in humans which include tumor antigen density, tumor environments, cytokine generation, cellular apoptosis, and other regulatory functions on TILs.[33] Immunoregulatory pathways like Fas/FasL have also been reported to be involved in tumor-specific immune generation in esophageal cancers.[34] This indicates that immune cells can generally recognize and respond to endogenous cancer cells and metastases/disease progression occurs only when immune response is unable to contain tumor progression.
Absence of unique tumor antigens, downregulation of target antigens, absence of adhesion molecule expression, and secretion of immunosuppressive cytokines have been the proposed reasons for immune evasion which is considered to be the possible reason of invasion and metastasis.[35]
The present study is unique since it is the first of its kind to assess the combined p53 and CD45RO+ immune response in SCCHN patients. The results of the study are congruent with the results of equivalent studies conducted on various types of cancers.[20],[21],[22],[23],[24],[25],[26] Hence, in node-negative SCC-CMs, immune cells are tumor antagonizing in nature.
Since we had not included node-positive cases, the role of CD45RO+ cells in metastasis could not be analyzed from the present study.
Future perspectives
We intend to extend the present study by assessing combined p53 and CD45RO expression at the epithelium-connective tissue interface and invasive front region of SCCHNs and thereby comparing the expression ratio with the results of the present study. Thereby, we wish to analyze the differences in the p53:CD45RO score ratio at different sites of the tumor which might throw more light on the role of immune cells at various points of progression of the tumor. Moreover, the study would be extended by including cases with nodal and regional metastases.
Clinical and therapeutic implications
Tumor-infiltrating CD45RO+ cells may materially improve patient outcome,[19] hence it can be used as an prognostic biomarker. The present study supports the applicability of p53:CD45RO expression as a prognostic biomarker for SCC-CM candidates.
Quantification of memory T-lymphocytes in a tumor site could provide feasible criteria for patient selection in clinical trials aimed at evaluating the efficacy of immunotherapy. Enhancement of the quantity and quality of memory TILs in situ may provide a novel strategy to improve the prognosis of cancer patients.[35]
In summary, p53:CD45RO ratio is significantly associated with significant lesser dedifferentiation and proliferation of the SCC-CMs independent of the clinical features. Our findings suggest that tumor-infiltrating CD45RO+ cells may materially improve patient outcome, offer a possible mechanism conferring an improved patient outcome, and support efforts to augment the host immune response as a therapeutic strategy.
1 Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
2 Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011;144:646-74.
3 Levine AJ, Oren M. The first 30 years of p53: Growing ever more complex. Nat Rev Cancer 2009;9:749-58.
4 Soussi T. The history of p53. A perfect example of the drawbacks of scientific paradigms. EMBO Rep 2010;11:822-6.
5 Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99.
6 Horimoto Y, Polanska UM, Takahashi Y, Orimo A. Emerging roles of the tumor-associated stroma in promoting tumor metastasis. Cell Adh Migr 2012;6:193-202.
7 Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013;14:1014-22.
8 Altin JG, Sloan EK. The role of CD45 and CD45-associated molecules in T cell activation. Immunol Cell Biol 1997;75:430-45.
9 Boon T, Coulie PG, Van den Eynde B. Tumor antigens recognized by T cells. Immunol Today 1997;18:267-8.
10 Baxevanis CN, Dedoussis GV, Papadopoulos NG, Missitzis I, Stathopoulos GP, Papamichail M, et al. Tumor-specific cytolysis by tumor-infiltrating lymphocytes in breast cancer. Cancer 1994;74:1275-82.
11 Gannot G, Gannot I, Vered H, Buchner A, Keisari Y. Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma. Br J Cancer 2002;86:1444-8.
12 MacLennan GT, Eisenberg R, Fleshman RL, Taylor JM, Fu P, Resnick MI, et al. The influence of chronic inflammation in prostatic carcinogenesis: A 5-year followup study. J Urol 2006;176:1012-6.
13 Song G, Hsiao H, Wang JL, Mannion C, Stojadinovic A, Avital I, et al. Differential impact of tumor-infiltrating immune cells on basal and luminal cells: Implications for tumor invasion and metastasis. Anticancer Res 2014;34:6363-80.
14 Boldrup L, Coates PJ, Laurell G, Nylander K. Differences in p63 expression in SCCHN tumours of different sub-sites within the oral cavity. Oral Oncol 2011;47:861-5.
15 Compton CC, Byrd DR, Gracia-Aguilar J, Kurtzman SH, Olawaiye A, Washington MK, editors. AJCC Cancer Staging Atlas. 2nd ed. New York: Springer; 2012.
16 Harris CC. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996;88:1442-55.
17 Nylander K, Dabelsteen E, Hall PA. The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck. J Oral Pathol Med 2000;29:413-25.
18 Weber A, Bellmann U, Bootz F, Wittekind C, Tannapfel A. Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck. Int J Cancer 2002;99:22-8.
19 Jochems C, Schlom J. Tumor-infiltrating immune cells and prognosis: The potential link between conventional cancer therapy and immunity. Exp Biol Med (Maywood) 2011;236:567-79.
20 Yajima R, Yajima T, Fujii T, Yanagita Y, Fujisawa T, Miyamoto T, et al. Tumor-infiltrating CD45RO(+) memory cells are associated with a favorable prognosis breast cancer. Breast Cancer 2016;23:668-74.
21 Rauser S, Langer R, Tschernitz S, Gais P, Jütting U, Feith M, et al. High number of CD45RO+ tumor-infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma. BMC Cancer 2010;10:608.
22 Peng RQ, Chen YB, Ding Y, Zhang R, Zhang X, Yu XJ, et al. Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer. World J Gastroenterol 2010;16:2428-34.
23 Enomoto K, Sho M, Wakatsuki K, Takayama T, Matsumoto S, Nakamura S, et al. Prognostic importance of tumour-infiltrating memory T cells in oesophageal squamous cell carcinoma. Clin Exp Immunol 2012;168:186-91.
24 Gao Q, Zhou J, Wang XY, Qiu SJ, Song K, Huang XW, et al. Infiltrating memory/senescent T cell ratio predicts extrahepatic metastasis of hepatocellular carcinoma. Ann Surg Oncol 2012;19:455-66.
25 Hiraoka N. Tumor-infiltrating lymphocytes and hepatocellular carcinoma: Molecular biology. Int J Clin Oncol 2010;15:544-51.
26 Hwang WT, Adams SF, Tahirovic E, Hagemann IS, Coukos G. Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis. Gynecol Oncol 2012;124:192-8.
27 Jia Q, Yang Y, Wan Y. Tumor-infiltrating memory T-lymphocytes for prognostic prediction in cancer patients: A meta-analysis. Int J Clin Exp Med 2015;8:1803-13.
28 Burnet FM. The concept of immunological surveillance. Prog Exp Tumor Res 1970;13:1-27.
29 Grossman Z, Herberman RB. 'Immune surveillance' without immunogenicity. Immunol Today 1986;7:128-31.
30 Adam JK, Odhav B, Bhoola KD. Immune responses in cancer. Pharmacol Ther 2003;99:113-32.
31 Stewart TJ, Abrams SI. How tumours escape mass destruction. Oncogene 2008;27:5894-903.
32 Blankenstein T, Coulie PG, Gilboa E, Jaffee EM. The determinants of tumour immunogenicity. Nat Rev Cancer 2012;12:307-13.
33 Gomez GG, Kruse CA. Cellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes reveals their up-regulated synthesis of biologically active TGF-beta. J Immunother 2007;30:261-73.
34 Kornberg LJ, Villaret D, Popp M, Lui L, McLaren R, Brown H, et al. Gene expression profiling in squamous cell carcinoma of the oral cavity shows abnormalities in several signaling pathways. Laryngoscope 2005;115:690-8.
35 Janeway C. Immunobiology. 5th ed. New York: Garland Publisher; 2001.


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New NONPOINT Album Will Be A Self-Titled Affair
July 11, 2012 0 Comment Nonpoint
"Left For You", a brand new song from NONPOINT, has been released via iTunes. The track comes off the band's self-titled seventh album, which is scheduled for release in the fall via NONPOINT's new label home, Razor Tie. The CD was produced and mixed by Grammy-nominated producer Johnny K (DISTURBED, STAIND, MEGADETH) and features additional production and mixing by Brian Virtue (30 SECONDS TO MARS, CHEVELLE). Virtue produced and mixed the first single, "Left For You".
Another new NONPOINT track, "I Said It", is available for streaming using the SoundCloud player below.
Founding NONPOINT members Elias Soriano (vocals) and Robb Rivera (drums) last year welcomed three new members to the family: Dave Lizzio (guitar), Adam Wolosyzn (bass), and Rasheed Thomas (guitar). All three musicians come from the Chicago-based rock act INN CINEMA.
NONPOINT's current lineup:
Elias Soriano – Vocals
Robb Rivera – Drums
Rasheed Thomas – Guitar
Dave Lizzio – Guitar
Adam Woloszyn – Bass
NONPOINT will hit the road this summer with CALL ME NO ONE.
NONPOINT's last album, "Miracle", sold around 8,000 copies in the United States in its first week of release to debut at position No. 60 on The Billboard 200 chart.
← PORTNOY: 'QUEENSRŸCHE Split Makes My DREAM THEATER Split Look Like A Walk In The Park'
TESTAMENT: Second 'Dark Roots Of Earth' Studio Webisode Available →
NONPOINT Parts Ways With Guitarist, Bassist
ATTIKA 7 Joined By Former KYUSS, NONPOINT Members
NONPOINT: New Audio Interview With ROBB RIVERA


Crystal Candle Holder. Panes and crystal in particular shot to popularity in the 18Th century. It was around the time that windshield makers in Czechoslovakia produced a new kind of lead amazingly that would enable them to function it more easily and set up more effects such as reducing, engraving or stenciling. The luster of the crystal was such that it became in superb demand for household items such as candlesticks. Most glass candle light holders are of the candelabra style with either a solitary candle or multiple members. Cut glass bowls generate effective floating candle dishes. Once the evenings turn more dark and the chilling weather is without question on us and welcomes the chances to cosy through to the sofa for a straightforward night in front of the fire. Pyschological data reports in the candle market when the demand of the candles is normally significantly increased during the cold weather seasons.
Nemiri - Diy wood herringbone counters hometalk. Diy wood herringbone counters 6 materials 2 days medium i want to start by saying thank you to all of you for your amazing comments and compliments after revealing the kitchen you guys are the reason i love sharing on hometalk a few of you asked what my island countertop was made of and when i responded, i was asked for a tutorial. How to diy: wood herringbone ceiling another great. Can you believe this is actually a budget ceiling?! this herringbone ceiling looks expensive if you're looking for basement ceiling ideas we've got another here for you this is a plywood ceiling and we've got the simple tutorial could be used to cover popcorn ceilings too! part of our budget basement makeover #howto #diy #decor #ceiling #basement #basementideas #budgetdecor. Herringbone wood flooring from havwoods usa. Herringbone wood flooring is the most popular of the wood patterns and is very much on trend we stock more than 25 different shade, finishes and sizes, perfect for both contemporary and traditional interiors order your free samples today. Herringbone flooring, chevron hardwood parquet solid and. A popular variation of the herringbone, called chevron or french herringbone, is prominent in many prestigious european chateaus using a form below select the type of herringbone you wish to order you may also order regular floor boards from matching wood by scrolling down the page to "plank and strip flooring" section. Herringbone pattern wood etsy. You searched for: herringbone pattern wood! etsy is the home to thousands of handmade, vintage, and one of a kind products and gifts related to your search no matter what you're looking for or where you are in the world, our global marketplace of sellers can help you find unique and affordable options let's get started!. How to make a wood herringbone pattern welsh design studio. Love a wood herringbone pattern, but think it's too complicated to make? i'm here to assure you that it's not in fact, i'm going to break it down for you into 6 easy steps that you can do without a lot of fancy tools!. Herringbone, chevron wood floors unfinished, prefinished. Herringbone, chevron wood floors unfinished, prefinished herringbone and chevron parquet floors are ordinarily installed one piece at a time forming several distinct patterns depending on what you desire for all intent and purposes the following deals with one piece products. Herringbone wood flooring carlisle wide plank floors. Carlisle wide plank floors provides herringbone wood floor options made from premium oak hardwood flooring learn more about wide plank oak flooring from carlisle unmatched quality and craftsmanship in every herringbone wood floor carlisle wide plank floors is a premium purveyor of the finest oak floors in the industry we selectively harvest. Diy herringbone wood paneled wall makely. Lindsay ballard is a former college mascot turned political geek turned roller derby playing, diy fanatic lindsay chronicles her projects, design ideas, and lifestyle tips here at makely, where she shares tutorials and diy designs are bold and graphic, while her spirit is fun and full of color. How to install a herringbone floor this old house. Herringbone slats must be cut to a length that is an exact multiple of their width but unless you're a math genius, first lay out pieces to see what approximate length will fit within your field; you want to land with a full length slat at each side.


The type material was collected from a conifer-broadleaf mixed forest.
Xu (2003) - Close to Carebara capreola, but head nearly square, only slightly longer than broad. Occiput with minute horns. Eyes present.
altinoda. Oligomyrmex altinodus Xu, 2003: 312, figs. 5-8 (s.w.) CHINA. Combination in Carebara: new combination (unpublished).
Holotype soldier. TL 3.7, HL 1.05, HW 0.95, CT 90, SL 0.50, ST 53, PW 0.58, AL 0.90, PL 0.45, PH 0.35, DPW 0.28. Head slightly longer than broad, roughly trapezoid in full face view and moderately narrowed forward. Occipital margin moderately concave. Occipital corners roundly prominent. Lateral sides slightly convex. Mandible with 5 teeth. Median portion of clypeus depressed longitudinally, bicarinate and divergent forward, anterior margin nearly straight. Antenna 11 segments with a 2-segmented club, apex of scape reached to 4/7 of the distance from antennal socket to occipital corner. Eye with 7 facets. In profile view, occiput with a pair of minute horns. Dorsum of head evenly convex. Promesonotum roundly convex. Promesonotal suture distinct. Mesonotum with a transverse furrow, posterior portion prominent and forming a transverse ridge behind the furrow. Metanotum present and tongue-like. Metanotal groove impressed. Propodeum with posterodorsal corner bluntly angled, dorsum straight and depressed longitudinally in the middle, declivity concave. Petiole pedunculated anteriorly, ventral face straight, anteroventral corner with a rightly angled tooth. Petiolar node narrow and high, anterior and posterior faces steeply sloped, dorsal face narrow and convex. Postpetiolar node roundly and anterodorsally convex, lower than petiolar node. In dorsal view, petiolar node width: postpetiolar node width = 1.0: 1.2, petiolar node transverse, postpetiolar node semicircular. Anterior border of gaster deeply concave in the middle in order to accept postpetiole.
Mandibles and median portion of clypeus smooth and shiny. Head densely and largely punctate, distance between punctures about equal to diameter of a puncture. Punctures on dorsum of head much denser. Anterior 1/3 of head longitudinally striate. Dorsum of promesonotum sparsely punctate, lateral sides of pronotum smooth and shining. Lateral sides of mesonotum, metanotum, propodeum, petiole and postpetiole densely and finely punctate. Dorsal face of petiolar node smooth and shining. Gaster sparsely and largely punctate, distance between punctures about 2-3 times of the diameter of a puncture. Head and body with dense decumbent pubescences. Frontal canna with 4 long erect hairs. Mesonotum, petiolar node, postpetiolar node and apex of gaster with sparse erect hairs. Scapes and tibiae with dense decumbent pubescences, without erect hairs. Head and gaster blackish brown, alitrunk, petiole and postpetiole reddish brown. Mandibles, antennae and legs yellow.
Paratype soldiers. TL 3.6-4.5, HL 1.00-1.08, HW 0.90-1.00, CI 90-93, SL 0.50, SI 50-56, PW 0.53-0.63, AL 0.90-1.03, PL 0.40-0.45, PH 0.33-0.38, DPW 0.25-0.30 (5 individuals measured). As holotype, but occipital horns minute to absent, posterodorsal corner of propodeum bluntly angled to rightly angled.
Paratype workers. TL 1.3-1.5, HL 0.38-0.43, HW0.35-0.38, CI 88-100, SL0.25-0.28, SI 67-79, PW 0.23-0.24, AL 0.40-0.43, PL 0.18-0.20, PH 0.15, DPW 0.09-0.10 (5 individuals measured). Similar to the holotype, but much smaller, head normal. Occipital margin weakly concave. Apex of scape reached to 5/6 of the distance from antennal socket to occipital corner. Eye with 2 facets. Occiput without horns. Promesonotum moderately convex. Promesonotal suture obsolete on the dorsum. Mesonotum without transverse furrow and ridge. Metanotum absent. Metanotal groove deeply impressed. Posterodorsal corner of propodeum rounded. Head, pronotum, petiolar node, postpetiolar node and gaster smooth and shining. Mesonotum, petiole and postpetiole without erect hairs. Head and body with short, sparse and depressed pubescences. Body yellow in color, head and gaster yellowish brown.
This page was last edited on 28 November 2018, at 11:41.


A key aspect of a successful LinkedIn campaign is connecting the professional social network to all your other social platforms such as Twitter and Facebook. All of your connections on LinkedIn should know of your presence on other networks. Whenever someone connects with your company on LinkedIn, that connection should be extended to them across all of your marketing platforms. LinkedIn and Twitter even allow information to be easily shared between the two networks by way of status updates.
It is important to remember how the users of LinkedIn contrast with Twitter users and that LinkedIn users differ in motivation for their use of the network. You can have all updates synced and shared between networks or they can be more fine-tuned. For example, on LinkedIn you can select to share all updates on Twitter with your LinkedIn connections or only updates containing the hashtag, #in. This feature allows the customization of your posts, limiting Twitter updates on LinkedIn to be only what you deem important enough for your connections to see. Often Twitter updates shared on LinkedIn have a longer lifespan than in the Twitter stream. Since LinkedIn works similarly to Facebook, with the level of interaction determining how long the post stays at or near the top of posts, visibility is improved for your posts.
It is vitally important to coordinate your updates on LinkedIn with your other marketing efforts so your company has a unified message delivered simultaneously. Plan your updates around the times of the day when it is most likely to be seen and noticed by your connections. Most people spend time on social media in the mornings and when they get a break at lunchtime. Posting at those times may get more attention for your messages.
Using LinkedIn effectively for marketing your business takes a considerable investment in time and effort. Maximize your impact by connecting LinkedIn to all your other social networks.


Gorgeous upgraded attached villa with heated pool and spa in lovely Esperanza section of Paseo. Enjoy private & quiet plush preserve views from the extended lanai. Among the features are beautiful hardwood floors in the main areas & berber carpeting, granite counters in the kitchen w/wood cabinetry w/lighting underneath, S.S. appliances & bead-board backsplash, plantation shutters, custom window treatment, crown molding, 5 fans, custom master closet, extra cabinets in laundry room, Pentair pool system & more. All within Paseo, with its wonderful resort pool complex, village w/movie theatre, dining, a fine fitness facility, ice cream parlour, library + it is in a South Ft. Myers prime location community tucked away off of Daniels Pky yet so close to I75, shopping, dining, hotels, 2 spring training baseball parks & more!
i75 to Daniels Pky, Exit 131, west to Palomino, turn right. Left at Penzance, right into Paseo. Past Grande Blvd to Paseo Drive. Turn right at Esperanza. Left at Esteban Drive. Property on left side of street.
Sign up to view market trends and price history for 11118 Esteban Dr.
I am interested in 11118 Esteban Dr, Fort Myers, FL 33912.


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Handy Rubbish › Willesden NW10 - Module
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Willesden lies in the north of London, in the London Borough of Brent. The area sits across the two postcode regions - NW10 and NW2. The region is served by its own tube station, Willesden Green which lies on the Jubilee line. The station itself is worth visiting, as it has a beautiful 1920s facade. Willesden Green also connects the area to the metropolitan line from nearby in days when the Jubilee line is not working. Despite the good connections to the centre of London, the urban development of Willesden has meant that the area is not as wealthy as it once was. Rapid development after the World Wars meant that the area was built up, mainly to provide jobs for people in the area. The region has a diverse cultural heritage, with small but prevalent groups of different nationalities sitting shoulder to shoulder. The area may be urbanized, but is still worth a visit, with many cafes and bars making it a nice place to live or work in.
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