text:
Background The aim of this study was to explore the role
Bessie Silva Blogging December 15, 2018 FHF4, MF63	0 Comment
Background The aim of this study was to explore the role of miR-199a-5p in the introduction of thyroid cancer, including its anti-proliferation effect and downstream signaling pathway. the cell routine in G0 stage. Transfection of miR-199a-5p inhibitors elevated the appearance of CTGF and marketed the viability from the cells by raising the small fraction of cells in G2/M and S stages. Conclusions Our research proves the fact that CTGF gene is certainly a focus on of miR-199a-5p, demonstrating the adversely related association between CTGF and miR-199a. These results claim that miR-199a-5p may be a book therapeutic focus on in the treating follicular thyroid carcinoma. genes and so are known to take place in follicular carcinomas, plus they have been released into scientific practice to facilitate accurate preoperative and postoperative medical diagnosis [5C7]. However, around 30% of most follicular carcinomas usually do not harbor MF63 any known mutations [8,9]. As a result, a breakthrough of extra molecular markers can be handy for improvement of medical diagnosis in these tumors. MicroRNAs (miRNA) is certainly a course of endogenous noncoding little RNAs, comprising 19 to 23 nucleotides, which adversely regulate the appearance of individual genes [10]. By biding towards the 3-untranslated area (3-UTR) of the prospective mRNAs, miRNA induces degradation of mRNAs or suppresses translation of the prospective protein [11]. It's been recommended that miRNAs control up to 30% from the human being genes and control mobile processes such as for example cell proliferation, advancement, apoptosis, as MF63 well as the immune system response [12]. MiRNAs are aberrantly portrayed or lost in a number of malignancies [13]. Many focus on mRNAs of miRNAs encode oncogenes and tumor suppressors; hence, dysregulated miRNAs may play a causal function in malignant development. And in addition, miRNAs are as a result considered attractive applicants for classification of tumors. The function of miRNAs in thyroid cancers is incompletely grasped. Several miRNAs have already been identified in a variety of thyroid tumors [14C16]. miR-197 and miR-346 are overexpressed in FC MF63 compared to adenoma, and research recommended that both miRNAs could MF63 possess a significant effect on tumour cell proliferation [14]. This present research is primarily centered on advancement of a biomarker for differential medical diagnosis of follicular thyroid cancers. Dettmer et al. performed miRNA microarray evaluation and likened the expression information of FHF4 follicular thyroid cancers and harmless control, and discovered a cluster of differentially portrayed miRNA [17]. Within this research, we chosen 5 miRNAs (miR-574-3p, -543-5p, 455-3p, 455-5p, and 199a-5p), and motivated their expression amounts in the malignant and harmless thyroid tissue examples. Material and Strategies Thyroid samples A complete of 42 follicular carcinomas (age group, 53.348.23, man: female, 11: 31) and 42 normal thyroid tissue (age group, 52.566.84, man: female, 14: 28) were analyzed. We gathered the snap-frozen tissue from examples of surgically taken out thyroid at our medical center, and the analysis protocol was accepted by the institutional ethics review plank at Zibo Town Peoples Medical center. Informed consent from all topics was attained. All diagnoses had been set up by at least 2 experienced pathologists. RNA removal and quantitative PCR (qPCR) Trizol reagent (Invitrogen, Carlsbad, CA) had been used to remove total RNA relative to the manufacturers process. Quantitative real-time PCR was performed with mirVanaTM qRT-PCR microRNA recognition package (Ambion, Austin, TX) to look for the relative expression degree of miRNAs (miR-574-3p, -543-5p, 455-3p, 455-5p, and 199a-5p) relative to the manufacturers process. Real-time RT-PCR was performed with the typical SYBR Green RT-PCR Package (Takara, Otsu, Japan) to identify the appearance of CTGF mRNA relative to the manufacturers process. The primer established for perseverance of CTGF mRNA appearance level was: forwards, 5-ACAAGGGCCTCTTCTGTGACTT-3 and invert, GGTACACCGTACCACCGAAGAT-3. 2-DDCt technique as well as the GraphPad Prism 4.0 software program (GraphPad Software, NORTH PARK, CA) were utilized to qualify the comparative appearance of miRNAs or CTGF mRNA as well as the miRNAs with U6 seeing that an interior control. 2?DDCt technique was utilized to calculate the family member expression degree of the miRNAs as well as the mRNA. Cell tradition and transfection FTC-133 (a follicular thyroid carcinoma cell collection) were bought from sigma-Aldrich (St. Louis, MO). DMEM with 100 g/mL streptomycin, 100 U/mL penicillin, and 10% FBS (Invitrogen, Carlsbad, CA, USA) was utilized to tradition the cells inside a humidified atmosphere with 5% CO2 at 37C. For the cell transfection assay, the man made miR-199a-5p mimic (5-CCCAGUGUUCAGACUACCUGUUC-3), the antisense RNA oligonucleotides particular for miR-199a-5p (miR-199a inhibitors) (5-GAACAGGUAGUCUGAACACUGGG-3), CTGF siRNA (5-GCACCAGCAUGAAGACAUA-3), and scramble control (5-UGGGCGUAUAGACGUGUUACAC-3) had been transfected into cells utilizing a lipofectamine RNAiMAX package (Invitrogen) at 50% confluence relative to the manufacturers process, and 48 h after transfection, the cells had been harvested.
Biofilm development is often associated with increased resistance toward antifungal agents.
Bessie Silva GlyR May 25, 2017 LIFR, MF63	0 Comment
Biofilm development is often associated with increased resistance toward antifungal agents. biofilms treated with AMB alone or in combination after 1?h of exposure, and SKN1 expression was even more sharply induced after 24?h. No statistically significant over expression of CDR1 was observed in biofilms after exposure to high doses of FLC, VOC or any of the combinations used. spp., LIFR Biofilm, Antifungal, CDR1, SKN1, KRE1 1.?Introduction species are the most common cause of fungal infections. induced infections range from non-life-threatening mucocutaneous illnesses to invasive processes that may involve virtually any organ. The growing frequency of hospital acquired especially bloodstream infections is due to the increased use of immunosuppressive therapy in cancer and transplant patients, which leads to breakdown of the barrier between the gut and bloodstream (Nucci and Anaissie, 2001). cells, as proven in many studies, are able to adhere to and colonize surfaces of medical devices, such as central venous catheters, orthopedic prostheses, intrauterine devices and prosthetic joints and valves, among others, resulting in the development of a biofilm (Douglas and Cobbs, 1992; Raad et al., 1993; Tunney et al., 1999). Infections due to the presence of fungal biofilms are a major clinical concern as these structures are seen as a improved level of resistance to antifungal therapy (Ramage et al., 2006). Different antifungal agents MF63 are accustomed to deal with these attacks, including azoles and polyenes (Pappas et al., 2004). Fluconazole (FLC) aswell as voriconazole (VOC), authorized in 2002, participate in the tiazoles, they hinder ergosterol biosynthesis by binding to lanosterol 14- demethylase (Richardson, 1990). The second option enzyme is vital for ergosterol creation, and inhibition of its activity which in turn causes disruption from the cell membrane resulting in growth inhibition from the fungus (Kelly et al., 1993). Amphotericin B (AMB) can be a member from the polyene family members (Warnock, 1991). This molecule binds to ergosterol and forms skin pores producing a disorganized membrane with an increase of permeability. Furthermore, AMB induces cell harm by producing MF63 lethal reactive air varieties (Brajtburg et al., 1990). The development of drug level of resistance within biofilms continues to be connected with a parallel upsurge in the maturation procedure (Sardi et al., 2011). Furthermore, some research show that biofilms of develop statically in the current presence of a minor matrix and show the same degree of level of resistance to antifungal treatment; as cells expanded in shaker and exhibiting huge amounts of matrix (Seneviratne et al., 2008; Sardi et al., 2011). However, several molecular mechanisms of resistance to antifungal MF63 agents in have been described. In particular, these include the increased efflux of antifungal agents due to the overexpression of efflux genes, CDR1 and CDR2 (the family of ABC membrane transport proteins C the ATP binding cassette) (Sardi et al., 2011). Moreover, changes in -1,6-glucan biosynthesis have also been proposed as a resistance mechanism against AMB (Gale, 1986). SKN1 and KRE1, two genes involved in -1,6-glucan biosynthesis (Mio et al., 1997), were found to be differentially expressed after exposure to antifungal treatment (Liu et al., 2005). A combined action of different mechanisms is believed to contribute to increased resistance, especially in the presence of persisters in the biofilm, which are able to tolerate high concentrations of antimycotics (Seneviratne et al., 2008). Interestingly, these persisters are not mutants but rather phenotypical.
In the title compound C15H12F3N3 the pyrazolo[1 5 ? 2005 ?);
Bessie Silva Alpha1 Adrenergic Receptors April 28, 2017 MF63, Pfkp	0 Comment
In the title compound C15H12F3N3 the pyrazolo[1 5 ? 2005 ?); Oliveira-Campos (2006 ?). to prepare materials for publication: = 1.5 for methyl organizations and = 1.2 in any other case. Numbers Fig. 1. Look at from the asymmetric device of the name compound displaying the atom labelling structure. Displacement MF63 ellipsoids are attracted in the 50% possibility level. H atoms are displayed by circles of arbitrary radii. Crystal data C15H12F3N3= 2= 291.28= 4.8715 (2) ?Mo = 11.2655 (5) ?Cell guidelines from 150 reflections= 13.5584 (6) ?θ = 3.0-24.6oα = 110.225 (3)oμ = 0.12 mm?1β = 96.808 (3)o= 293 (2) Kγ = 99.835 (3)oBlock yellow= 675.13 (5) ?30.98 × 0.21 × 0.20 mm Notice in another windowpane Data collection X8 APEXII diffractometer2200 reflections with > 2σ(= 293(2) Kθutmost = 29.7oφ and ω scansθmin = 1.6oAbsorption correction: multi-scan(XPREP; Bruker 2006 ?6→6= ?15→1516787 measured reflections= ?18→183757 independent reflections View it in a separate window Refinement Refinement on = 1/[σ2(= (= 1.05(Δ/σ)max < 0.0013757 reflectionsΔρmax = 0.40 e ??3190 parametersΔρmin = ?0.45 e ??3Primary atom site location: structure-invariant direct methodsExtinction correction: none View it in a separate window MF63 Special details Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle MF63 between two l.s. planes) MF63 are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.Refinement. Refinement of and goodness of fit are based on are based on set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F and R– factors based on ALL data will be even larger. Notice in another windowpane Fractional atomic coordinates and comparative or isotropic isotropic displacement guidelines (?2) xconzUiso*/UeqN4?0.1395 (3)0.64063 (13)0.15766 (10)0.0437 (4)C510.2301 (3)0.60519 (16)0.27094 (13)0.0434 (4)C50.0595 (3)0.69036 (16)0.24463 (12)0.0427 (4)N1A?0.2415 (3)0.85107 (14)0.19699 (11)0.0475 (4)C3A?0.2918 (3)0.71919 (16)0.13244 (13)0.0443 (4)C7?0.0385 (4)0.90322 (17)0.28737 (15)0.0517 (4)N1?0.4126 (3)0.91420 (15)0.15720 (13)0.0560 (4)C60.1130 (4)0.82475 (17)0.31325 (14)0.0501 (4)H60.25140.85770.37530.06*C560.2277 (4)0.48484 (18)0.19505 (14)0.0526 (5)H560.11650.45750.12710.063*C550.3880 (4)0.40510 (18)0.21898 (15)0.0571 (5)H550.3810.32450.16680.069*C520.4029 (4)0.64261 (19)0.37085 (15)0.0584 (5)H520.40970.7230.42330.07*C540.5592 (4)0.44182 (19)0.31862 (15)0.0539 (5)C3?0.5081 (4)0.69986 (19)0.04969 (15)0.0514 (4)H3?0.59390.622?0.00680.062*C2?0.5725 (4)0.81980 (18)0.06756 (15)0.0522 (5)C530.5645 (5)0.5626 (2)0.39352 (16)0.0631 (5)H530.67960.59060.46080.076*C80.7329 Pfkp (5)0.3537 (2)0.34284 (18)0.0700 (6)H8A0.70310.27540.28070.105*H8B0.67630.33270.40140.105*H8C0.93030.39670.36190.105*C710.0064 (5)1.0448 (2)0.3532 (2)0.0714 (6)C21?0.7881 (4)0.8562 (2)0.00171 (18)0.0689 (6)H21A?0.78280.94710.03530.103*H21B?0.97380.8064?0.00360.103*H21C?0.74570.8385?0.06860.103*F3?0.2264 (3)1.07474 (12)0.38784 (11)0.0893 (5)F10.2076 (3)1.07989 (12)0.43939 (12)0.1008 (6)F20.0852 (3)1.11914 MF63 (12)0.29935 (14)0.1004 (5) Notice in another windowpane Atomic displacement guidelines (?2) U11U22U33U12U13U23N40.0444 (8)0.0425 (8)0.0452 (7)0.0121 (6)0.0056 (6)0.0175 (6)C510.0427 (9)0.0434 (9)0.0449 (9)0.0114 (7)0.0059 (6)0.0177 (7)C50.0430 (9)0.0401 (9)0.0447 (9)0.0100 (6)0.0078 (6)0.0155 (7)N1A0.0449 (8)0.0430 (8)0.0557 (8)0.0131 (6)0.0048 (6)0.0197 (7)C3A0.0449 (9)0.0425 (9)0.0476 (9)0.0113 (7)0.0081 (7)0.0191 (7)C70.0478 (10)0.0399 (9)0.0606 (11)0.0105 (7)0.0043 (8)0.0121 (8)N10.0507 (9)0.0533 (10)0.0723 (10)0.0189.


text:
I Crodaioli è stato un coro di ispirazione popolare di sole voci maschili, con sede ad Arzignano (Vicenza), fondato nel 1958 ed attivo fino al 2019.

Storia
Il coro esegue e divulga canti di ispirazione popolare, composti dal suo fondatore e direttore, Bepi De Marzi, molti dei quali eseguiti da cori di tutto il mondo. (Signore delle cime è stato tradotto in centotrentaquattro lingue).

In sessant'anni, continuamente rinnovati nei quattro settori vocali, hanno effettuato più di tremila concerti in ogni parte del mondo e hanno pubblicato circa centocinquanta nuovi canti.

Discografia
1968 - Voci della montagna Vol.1 (Carosello Record & tapes)
1981 - Voci della montagna Vol.2 (Carosello Record & tapes)
1981 - I Crodaioli di Bepi De Marzi Vol.3 (Carosello Record & tapes)
1977 - Varda che vien matina Vol.4 (Carosello Record & tapes)
1981 - Calastoria Vol.5 (Carosello Record & tapes)
1985 - I Crodaioli di Bepi De Marzi Vol.6 (Carosello Record & tapes)
1991 - I Crodaioli di Bepi De Marzi Vol.7 (Carosello Record & tapes)
1995 - I Crodaioli di Bepi De Marzi Vol.8 (Carosello Record & tapes)
2005 - I Crodaioli di Bepi De Marzi Vol.9 (Carosello Record & tapes)
2006 - Salmi di padre David Maria Turoldo (Casa Musicale Edizioni Carrara di Bergamo)
2016 - Antologia 1 e 2

Note

Altri progetti

Collegamenti esterni

 Crodaioli e Cantori delle Cime a Lugano, dal Corriere del Ticino del 30 gennaio 1978 (I Crodaioli di Bepi De Marzi ospiti de I Cantori delle Cime a Lugano)
 Voci del monte in città, dal Corriere del Ticino del 30 novembre 1992 (I Crodaioli ospiti de I Cantori delle Cime a Lugano)
 Poesia e calore della corale, dal Corriere del Ticino del 14 novembre 1983 (I Crodaioli ospiti della Vos da Locarno)

Cori alpini e popolari italiani
Cori polifonici italiani
Provincia di Vicenza
Gruppi e musicisti del Veneto
Cori legati agli alpini

redpajama_set_name: RedPajamaWikipedia


text:
Publications (Catalogs, Newspapers, Yearbooks, Alumni Magazines, etc.)
Alumni Magazines
Kalamazoo College Alumnus (July, 1955)
Searchable PDF (2.812Mb)
Commencement -- From President Hicks -- Groetsema Speaks On Alumni Day "The Forth "R"" -- Pollard Speaks At Commencement "Living Well In A Dangerous World" -- Break Ground For Upton Hall -- Functions Of Education Dept. -- News From The Campus -- Speaking of Books / Dr. Arnold Mulder -- Interested In Kalamazoo History? -- Baseball Diamond Underway -- Sports News -- Club News -- Alumni Notes.
Alumni Magazines [303]
Olds Upton Science Building [25]
Kalamazoo College Self-Study Report: A Decade of Change, Challenge, and Promise. Prepared for the Higher Learning Commission of the North Central Association of Colleges and Schools.
Kalamazoo College (2003-03)
The title of this report—and of this introductory chapter—was chosen with some trepidation, for what college could not say that the past decade, or any ten-year period of its history for that matter, was a time of change, ...
Kalamazoo College Response to The Higher Learning Commission, A Commission of the North Central Association of Colleges and Schools
Kalamazoo College (2006)
In the Assurance Section of its Report of a Comprehensive Evaluation Visit to Kalamazoo College in April of 2003, the Evaluation Team identified a number of"inadequately addressed" issues that needed "further clarification." ...
CACHE: College ACademic and Historical Experience at Kalamazoo College
Nowicki, Stacy, 1973-; Lightcap, Kathryn; Butler, Heidi (2008-10-22)
This presentation was part of the Michigan Library Association annual conference in Kalamazoo, Michigan on October 22, 2008. It is an overview of CACHE, the Kalamazoo College institutional repository, and was given by Stacy ...

redpajama_set_name: RedPajamaCommonCrawl


I'm so excited to offer you my new fake Ice Cream cones! They look very delicious and very realistic!!
This is a cake cone topped with a delicious scoop of cookies and cream Ice Cream and topped off with chocolate syrup, more cookie pieces and a cherry!
My items are lovingly handmade, one at a time, making each item a true work of art.
I love using these in sweet displays along with cupcakes, donuts, candies and other pies and cakes.
They go wonderfully with other the faux sweets offered in my shop, including more ice cream cones, so be sure to take a look around!
Original design by me, Debra Lea. None edible, decorative purposes only.


text:
The Last Samurai - Import - Limited Edition Steelbook (Region 1) (UK EDITION)
Set in Japan during the 1870s, The Last Samurai tells the story of Capt. Nathan Algren, a respected American military officer hired by the Emperor of Japan to train the country's first army in the art of modern warfare. As the Emperor attempts to eradicate the ancient Imperial Samurai warriors in preparation for more Westernized and trade-friendly government policies, Algren finds himself unexpectedly impressed and influenced by his encounters with the Samurai, which places him at the center of a struggle between two eras and two worlds, with only his own sense of honor to guide him.


text:
using Shouldly;

namespace Tests.Caliburn.Core
{
    using System;
    using System.Linq;
    using System.Reflection;
    using global::Caliburn.Core;
    using global::Caliburn.Core.Configuration;
    using global::Caliburn.Core.Invocation;
    using global::Caliburn.Core.InversionOfControl;
    using Xunit;

    public class The_core_configuration : TestBase
    {
        CoreConfiguration config;
        IModule module;

        protected override void given_the_context_of()
        {
            config = ConventionalModule<CoreConfiguration, ICoreServicesDescription>.Instance;
            module = config;
        }

        [Fact]
        public void when_started_configures_required_components_and_children()
        {
            var registrations = module.GetComponents();

            var found = (from reg in registrations.OfType<Singleton>()
                         where reg.Service == typeof(IMethodFactory)
                         select reg).FirstOrDefault();

            found.ShouldNotBeNull();
            found.Implementation.ShouldNotBeNull();

            found = (from reg in registrations.OfType<Singleton>()
                     where reg.Service == typeof(IAssemblySource)
                     select reg).FirstOrDefault();

            found.ShouldNotBeNull();
            found.Implementation.ShouldNotBeNull();
        }

        [Fact]
        public void can_provide_a_custom_method_factory()
        {
            config.Using(x => x.MethodFactory<FakeMethodFactory>());

            var registrations = module.GetComponents();

            var found = (from reg in registrations.OfType<Singleton>()
                         where reg.Service == typeof(IMethodFactory)
                         select reg).FirstOrDefault();

            found.Implementation.ShouldBe(typeof(FakeMethodFactory));
        }

        class FakeMethodFactory : IMethodFactory
        {
            public IMethod CreateFrom(MethodInfo methodInfo)
            {
                throw new NotImplementedException();
            }
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
California campus police on leave after pepper-spraying
The University of California at Davis placed two police officers on administrative leave after they pepper-sprayed non-violent protesters at point-blank range, the school announced Sunday.
Video of the Friday incident has led to calls for the resignation of UC-Davis Chancellor Linda Katehi, who made the announcement of the officers on leave in a written statement Sunday afternoon. Katehi said she shares the "outrage" of students and was "deeply saddened" by the use of the chemical irritant by campus police.
"As chancellor, I take full responsibility for the incident," she said. "However, I pledge to take the actions needed to ensure that this does not happen again."
The school said the 10 protesters arrested were given misdemeanor citations for unlawful assembly and failure to disperse. Eleven protesters were treated for the effects of pepper spray, which stings the eyes and induces coughing, gagging and shortness of breath.
Filed under: California • Crime • Occupy Wall Street
soundoff (26 Responses)
JAMES DOW
FIRE THEM!
My friends in Eastern Europe are Shocked at what they are seeing!
How does this look to the rest of the World?
They should be ashamed of themselves and relegated to the poverty they seem to despise by being fired and forever saddled with the shame of what they have done, the way they've treated their Peaceful fellow Human Beings is appalling!
November 20, 2011 at 6:53 pm | Report abuse |
Thank you, JAMES. I couldn't agree more! These guys are employed and have no idea of what it's like to be poor and unemployed and not to be able to pay their bills!!!
I agree. I mean they were not being threatened in any way. The protesters were sitting down. Passively. Sitting, doing nothing to harm anyone. And you can clearly see the police walk up to them and spray them as closely in the face as they could. I think they have no business in that line of work. AND should be sued for assault. They are creeps. It's one think if they were being threatened, or assaulted, but no one was throwing rocks at them, shooting them, punching them. They just wanted to assault some college kids.
November 23, 2011 at 11:55 pm | Report abuse |
Is there anyone whose name you won't steal, George Patton troll? Jerry's been here what, 1 day?
They pepper sprayed people sitting down. Stupid little men with a Napolean complex. Fire them!
Sad, yes. But you've gotta admit, it was also pretty funny. The 'cop' and his WWE type gestures before unloading the canister had me laughing. And you laughed too, admit it. Also, did this guy really not consider that EVERTHING gets video-ed nowadays?
I think it is immoral when the right wing thugs in Washington are spraying peaceful protesters, but it is fine when the Russian, Chinese, and Cuban police do it.
I see that some mindless Tea Partier here is trying to be funny by usurping my name and posting the above to discredit me. Of course I never condone such action by anybody! I guess that these Tea Partiers don't like to be proven just how dumb they are!!!
November 21, 2011 at 9:54 am | Report abuse |
**cosmicvox *
It's time to watch "The Road Warrior" again so I can remember how great Anarchy is.
November 21, 2011 at 12:32 am | Report abuse |


The true story of writer Lee Israel, who loses her job, only to find much more money and creative satisfaction from forging celebrity letters and selling them.
Having shot to fame in Bridesmaids, Melissa McCarthy has pretty much stuck to her winning schtick. But for the first time, at least in memory, she has displayed there is so much more to her, with a wonderful portrayal of writer Lee Israel, a struggling writer and stereotypical older cat lady.
After losing a dead end job she hated, Israel struggles to make ends meet, ultimately finding and selling a Fanny Brice letter she comes across. When informed that she could have got a lot more money if the letter was more lurid and juicy, she gets her creative brain in gear, and over the following years, and with multiple old fashioned type writers, she creates numerous fabricated letters from well known celebrities such as Noel Coward, to make a sizeable income.
She is aided in her endeavours by fellow misfit Jack Hock, and the two lonely and somewhat tragic characters seem to find some sense of meaning in their companionship – that is until the net starts closing in.
McCarthy is wonderful in the role, and is wonderfully supported by Richard E Grant in one of his greatest performances, channelling Withnail all the way – hence both their Oscar nominations.
An interesting story of human frailty comprising huge highs and large lows, with two top turns from the leads.


I barely have anything done, just a few ideas and concepts I am playing around with. I intend to release more details later.
i played that mini gam and what is ur game about?
Yep, there is or was a mini-game on Google.com about it.
Today is the Doctor Who 50th Anniversary. Rejoice!
I am indeed working on a Game, but I have yet to fully learn how to use Stencyl. It might be a while before I publish it!


text:
OldSewinGear
Slant Needle >
601 / 603 /604
Class 15 Machines
Swing Needle
Toy Machines
Discs & Cams
Japan Class 15
Singer 401A's Dirty Little Secret...
The Singer 401A is legendary for its durability and power. Like the old Timex, it can take a lickin' and keep on stitchin.' After all, it has steel gears, doesn't it?
Yes, the 401A is famous for it's Made in the USA steel gears, but did you know that the 401A has ONE gear that is NOT steel?
In fact, the gear in question isn't even metal.
"Say it ain't so, Joe..."
The 401A is often touted as an "all metal" or "all steel" sewing machine, but neither description is strictly accurate.
The 401A machine head is cast aluminum, which is lighter-weight than the earlier cast iron straight-stitch machines. The 401A's casting is heavier than the Featherweight 221 or 301, but it's still aluminum.
Inside the 401A, the needle bar, cam-stack, cam followers, hook, and driving gears are nearly all steel parts.
Nearly...
Nylon handwheel gear - Singer 401A
The exception is the large gear that sits just inside the handwheel and engages the upper machinery to the vertical motor drive shaft. This particular gear is 1/2 inch thick and made of an extremely durable plastic composite.
It may not be steel, but whatever the stuff is, it stands the test of time, because you never hear of this gear stripping, breaking, or cracking. Unlike the plastic and nylon gears that Singer used on later models, this substance just quietly does its job year after year after year.
The material in question is most likely Textolite, which consisted of woven fibers infused with bakelite. If you examine these gears closely you can see the cross-hatch of woven fibers, and the service manual for Singer 201 refers to a similar gear as a "textolite gear." Textolite was a brand-name patentend by GE in 1936 and heavily promoted through the 1950's for everything from laminate counter-tops to tile floors.
So now you know the 401A's dirty little secret. It's not "all steel" and it isn't even "all metal." But it is still unquestionably one of the finest Singer sewing machines ever built.
OldSewinGear...dedicated to helping you get the most out of your old sewing gear.
Updated 12/13/14: Thank you to members of the Vintage Sewing Machine Facebook group for prompting further research into Textolite, which led to revisions of this article!
Peg Smith
I bought a singer 401A, second hand, in 1969. Been using it to do all sorts of sewing from girls clothing, my clothing, upholstering chairs, making waterproof curtains for our camper, and various other projects. It is the best machine ever! Mine is still going strong. Nice to get your info on the gears!
Peg S.
Lizzie link
Glad to have found this post! I am currently doing up a Singer 411G, and I had realized that the handwheel gear wasn't metal, although wasn't sure what it was made from. The thing is - do you lubricate yours?? I have read all sorts of conflicting advice about lubricating, or not, plastic/nylon/fibre gears. I'd be grateful for more advice!
I don' know anything about gears, but I love my Singer 401! I do not lube it, but a while back (a long while back!) I had a man come to the house and he went all over it; belts, lube, cleaning. It still runs like a charm. But unfortunately I don't use it much anymore. Mostly I use it for mending. I see projects that I would like to do, but my get-up-and-go seems to have got-up-and-gone. Thought I might sew for granddaughters, but the older one won't wear homemade things, and the younger one wears a uniform to school. Oh well, back in the day, I made one of my prom dresses, my wedding gown, a tailored Easter suit, a sports coat for my bro, and many more lovely and fun things. Thanks for listening!
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Why A Swiss Bridge In Our Logo?
possible when technology, innovation, execution, and design converge.
Bridger has its roots in providing California auto insurance since 1974, and grew to become one of the state's largest providers. When Bridger took over in 2017, it did so with the intent of continuing to build on a successful legacy.
Quite simply, we are bridging the past to the future through innovative insurance products and technology, designed for a new generation of users. Simplifying the transactional process of insurance and speed through which claims are filed is one of Bridger's main goals.
With a broker network exceeding 1,500 locations, California auto insurance with Bridger is just around any corner. The company holds licenses in Arizona and Texas and is planning further expansion beginning in 2018.
At 6'4″, Kimo has the height to see into the future as Bridger's visionary leader. With vast start-up experience raising more than $100-million in capital, he's assembled an A-team of leaders to help guide Bridger's path. He's a get-it-done type guy with a passion for driving new insurance technologies and products.
Farhan's gears are always turning as the company's lead engineer and statistician. He knows how to crunch and analyze the numbers through actuarial science, program management, analytics, and technology. He strives to take insurance to the next evolutionary step and is guided by a drive to turn such visions into reality. Agents... are you looking for new markets?
As Bridger's President, Adam's role is to keep the troops in line, operations running smoothly, and to lead the implementation of Bridger's vision. His versatile experience in the financial and insurance sectors provide him that unique ability to evenly balance the needs of the company with the drive to make it ever more successful.
DeeDee's versatility keeps everyone in the company on their toes. She drives much of the company's culture for an open and fun environment, streamlines and creates a more practical flow for operations and administration, promotes collaboration, and ensures Bridger remains compliant with Federal and State regulations.
Chris is driven by the challenge of constant dissatisfaction with the status quo; always searching for new opportunities. He is focused on new business development, products, and helping develop Bridger's strategic plans for expanding services, carrier relationships and helping take the company into new markets.
David claims to be the best in claims. He's built a strong in-house team to help Bridger's insureds smoothly navigate the claims process. With claims being the only time most insureds are in direct contact with their insurance company, David's team strives to make it as pleasant an experience as possible.


text:
Tom Cruise Tops Forbes Magazine's List of Highest Paid Actors in 2012
The Mission: Impossible star leaves other actors in the dust with $75 million in earnings.
Actor Tom Cruise of Mission: Impossible fame may be experiencing problems in his marriage--he just filed for divorce from his wife, Katie Holmes--but when it comes to his career, he's still flying high. In fact, he just topped Forbes Magazine's list of Hollywood's Highest Paid Actors this year.
According to Forbes.com, Cruise took home $75 million in earnings from May 2011 to May 2012, largely due to the profits he got from Mission: Impossible--Ghost Protocol, which generated $700 million in revenues globally. He also has an upcoming flick called Oblivion.
In comparison, second placers Leonardo DiCaprio and Adam Sandler each earned an estimated $37 million--$38 million less than Cruise. Other top-ranking actors include Dwayne Johnson with $36 million and Ben Stiller with $33 million.
Meanwhile, actors Sacha Baron Cohen, Johnny Depp, and Will Smith each earned $30 million.
Rounding out the list are Mark Wahlberg, Taylor Lautner, and Robert Pattinson.
(Photo by Ian via Flickr Creative Commons)
Forbes Forbes.com Tom Cruise
Pilita Corrales Reveals She Was a Battered Wife for 10 Years
Epic: A Family Film for 2013


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text:
Q: Who or whom? How to substitute him or her for whom here?

*

*My brother who I'm older than him, lives in Paris.

*My brother whom I'm older than[NOT than him], lives in Paris.

*My brother who's younger than me lives in Paris.

Why should we ommit "him" after "than" in the second example? Is this necessary?
How can we use this recommended trick here, for the example number 2?
How to substitute him for whom? How to rearrange the word order here?
Are the first and third examples the same? (in terms of meaning)
Are they true?

A: *

*The 'him' is redundant. It is a pronoun that is supposed to take the place of the noun referred to (your brother) but your brother is already in the sentence so does not need to be represented by a pronoun.

So "My brother, who I am older than, lives in Paris" (please note the use of commas) is grammatically OK but sounds very unnatural to a native speaker.
2.'whom' is wrong here because 'whom' must refer to the object of a verb , and your brother is not the object of the sentence but is actually the subject of the sentence:'My brother...lives in Paris'. You are describing what your brother is  - younger than you - not referring to him as the object. You could have 'whom' if the description of your brother took a different, adjectival, form. For example, you could say "My brother, wiser than whom no Frenchman can be, lives in Paris". That means the same as 'My brother, who is wiser than any Frenchman, lives in Paris'. The difference is that the descriptive clause in the first case describes Frenchmen and in the second it describes your brother.

*is fine, but @HankyPanky's version is better.

redpajama_set_name: RedPajamaStackExchange


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1MATCH URL: https://assets.rappler.com/75C88BB4389E47FE924A422B997971AE/img/B42FB4DEC53A435ABDA204703D0B0E9E/20190623-coa-cavite.jpg
COA asks Cavite gov't to explain P4.95 million paid to consultants
(UPDATED) The Cavite provincial government has replied to auditors, who want justification that consultants' scope of work are beyond the in-house capability of the province
Published 4:25 PM, June 23, 2019
Updated 5:25 PM, June 25, 2019
MANILA, Philippines (UPDATED) – The Commission on Audit (COA) asked the Cavite provincial government to explain the P4.95 million paid to 24 consultants and to justify why these consultants were hired in 2018.
In an audit report, COA said the consultants were hired without the "assurance that their service were beyond the in-house capability of the province."
State auditors said the contracts of the consultants did not identify the scope of work, terms of reference, time frames, and expected deliverables. These only stated their educational attainment, work experiences, and the fees ranging from P10,000 to P30,000 monthly.
This, the auditors pointed out, was a violation of Republic Act No. 9184 or the Government Procurement Reform Act and COA Memorandum No. 2005-027 on the documentary requirements for government projects.
"The incurrence of P4,945,909.09 for consultancy services was not justified," COA said.
The audit report showed that there were 10 special assistants to the governor, 4 consultants for special concerns, and one consultant for the governor.
The others were for agricultural modernization, education, finance and real estate taxes, investor relations, investor affairs, legal and labor affairs, opthalmology, traffic management, and water resources.
COA also questioned the duration of the contracts of the consultants, with 4 who have been repeatedly hired since 2010, 1 since 2013, 9 since 2016, 8 since 2017, and 2 since 2018.
The office of the Cavite governor, who was then Jesus Crispin Remulla, was furnished a copy of the report on May 31.
COA recommended that Remulla direct the human resources management officer to submit the consultancy contracts with a "clearly defined" scope of work to the audit team.
In a phone interview with Rappler, Remulla on Tuesday, June 25, said that his office had responded to COA's request this month. Remulla is the outgoing governor of Cavite.
"We already wrote them a letter to explain. In fact, we were able to reduce the number of consultants by 60% from the administration of [Erineo] Maliksi," he told Rappler.
Remulla said that their contract included the consultants' work experience because they thought it would be sufficient to "justify their hiring." – Rappler.com
Filed under:COA reports•Commission on Audit•Jesus Crispin Remulla•Cavite


Our most popular design, the buttercup, is now available in a mini size in a collection of bold & rich colors. Hand-made from fine satin and premium poplin in the USA, each flower is unique to you & is a staple for all occasions, whether casual, business or formal. There is no easier way to tailor the look of a suit jacket or blazer than with the original HOOK & ALBERT lapel flower. Just be prepared for the compliments.


text:
Hadelinus, ook Hadelinus van Celles of Hadelinus van Wezet, (rond 617, Aquitanië - 3 februari 690, Celles) was een leerling van de H. Remaclus, abt en kloosterstichter. Hij wordt vereerd als heilige.

Hadelinus trad in bij de monniken van de abdij van Solignac, waar Remaclus abt was. Met Remaclus trok Hadelinus naar de Ardennen en belandde in de door Remaclus gestichte abdij van Stavelot. Nadat Remaclus bisschop van Maastricht geworden was, volgde Hadelinus zijn eigen weg. Dankzij schenkingen van landerijen door Pepijn van Herstal stichtte hij een klooster in Celles bij Dinant. Hadelinus werd gezien als raadgever voor arm en rijk. Tijdens de middeleeuwen ontstonden verschillende wonderbaarlijke verhalen over Hadelinus. De weerkerende legenden zijn de genezing van de doodzieke echtgenote van de heer van Béon, de genezing van een doofstomme vrouw, het doen ontspringen van een fontein in Franchimont bij Philippeville en het uit de dood opwekken van een vrouw met de naam Guiza.

De kloosterkerk van Celles werd na de dood van Hadelinus omgevormd tot een kapittel. Door problemen met de plaatselijke dorpsheer werden de relieken van Hadelinus 11 oktober 1338 op aanwijzing van de prins-bisschop van Luik overgebracht naar de kerk van Wezet nabij Luik. Dankzij het onderbrengen op tijdelijke vluchtplaatsen voor het geweld van de beeldenstormers, revolutie en de twee wereldoorlogen, zijn de relieken en het reliekschrijn (12e eeuw, met 11e-eeuwse elementen) bewaard gebleven en in de Kapittelkerk van Sint-Martinus en Sint-Hadelinus te Wezet ter verering opgesteld. De abdij in Hastière (ca. 915 gesticht door paltsgraaf Wigerik van Lotharingen) wordt naar Hadelinus vernoemd.

Hadelinus is patroonheilige van Wezet. Het reliekschrijn van Hadelinus wordt op de jaarlijkse Hadelinusprocessie (derde zondag in september) rondgedragen. Zijn gedachtenis wordt gevierd op 3 februari.

Heilige in het christendom
Belgisch heilige of zalige
Persoon in de Nederlanden in de 7e eeuw
Merovingisch heilige
Celles


text:
Almora Bageshwar Chamoli Champawat Dehradun Garhwal Hardwar Nainital Pithoragarh Rudraprayag Tehri Garhwal Udham Singh Nagar Uttarkashi All Districts
Socio-Economic Statistical Data of Uttarakhand
Andhra Pradesh Arunachal Pradesh Assam Bihar Chhattisgarh Goa Gujarat Haryana Himachal Pradesh Jammu & Kashmir Jharkhand Karnataka Kerala Ladakh Madhya Pradesh Maharashtra Manipur Meghalaya Mizoram Nagaland Odisha Punjab Rajasthan Sikkim Tamil Nadu Telangana Tripura Uttar Pradesh Uttarakhand West Bengal
Home Uttarakhand
About District Cold Storage Agricultural Area/Land Use Agricultural Co-operatives Agricultural Exports Agricultural Implements and Machinery Agricultural Imports Agricultural Institutional Finance Agricultural Land Holdings Agricultural Marketing Agricultural Offtake Allocation and Procurement Agricultural Prices Agricultural Production Agricultural Wages Agricultural Workforce Animal Husbandry/Livestock Consumption of Fertilisers Consumption of Pesticides Fisheries (Aquaculture) Horticulture HYVP Crops Irrigation Kisan Credit Card Livestock Census Milk and Dairy Products Minor Irrigation Others Poultry Seeds Warehouses Water Resources
About Almora District (Uttarakhand)
Almora district, a part of the Kumaon division is a district of the Uttarakhand state with its administrative headquarters located at Almora town. Prior to the establishment of the ancient Almora town, it was under the control of Baichaldeo, a Katyuri king. He then decided to donate a large part of this land to Sri Chand Tiwari, a Gujrati Brahmin. After sometime when Baramandal was under the Chand kingdom, at that time Kalyan Chand made the Almora town, a centrally located place in 1568. During those days of the Chand Kings it was popularly known as Rajapur. Even today also the name 'Rajapur' is clearly visible on some ancient copper plates, discovered in the region of Almor. Almora as a separate district came into existence in the year 1568. On the other hand after the defeat of of Gorkha army in the Anglo-Gorkha war and the 1816 Treaty of Sugauli, Almora town was declared as the administrative headquarter of the Kumaun district, formed in 1815. At that time Kumaun district comprised of the entire Kumaon division excluding the Terai district with its headquarters located at Kashipur. In the year 1891 the Nainital district was carved out of the Kumaun district and later Kumaon district was renamed it as Almora district after the name of its headquarter. Earlier, in the period of 1960s Bageshwar district, Pithoragarh district and Champawat district were part of the Almora district.
Geographically, the district lies at 29°60'N latitude, 79°66'E longitude and 1861 m altitude. In the year 2019, there was a total 54.68% forest area of total geographical area. The district encompasses a geographical area of 3,144 sq km. and it is bounded by Chamoli district and Bageshwar district on the North, Nainital district and Champawat district on the South, Pithoragarh district on the East and Pauri Garhwal district on the West. The climate of the district is not so hot in the summer and not too cold in the winter. Most of its rainfall occurs in the monsoon season. The actual rainfall in the district was 1047.5 mm in the year of 2019-20.
Administration wise, the district is divided into 9 sub-districts, 5 towns and 2,289 villages. The administrative language in the district is Hindi.
According to 2011 census the district has a population of 6,22,506 out of which 2,91,081 are males and 3,31,425 are females. The district has a sex ratio of 1139 (females for every 1000 males). During the year 2001-2011 the population growth rate in the district was -1.28% including -0.94% were males and -1.57% were females. As per 2011 census the major religion in the district is Hindu with 98.19% of the total population. The population density in the district is 198 persons per sq. km. According to 2011 census the principal language in the district is Hindi with 98.74%. In the year 2018 the number of live births in the district was 15,506 including 7,759 were males and 7,747 were females. In the same year the number of deaths in the district was 3,889 including 2,059 were males and 1,830 were females.
Agriculture is the backbone of the economy of the district. Most of the lands in the district are use for agricultural purposes. More than half of its population are engaged in agriculture in order to earn their livelihood. The chief agricultural products in the district are rice, wheat, millet, tea, apples, peaches, apricots, plums, etc. The adoption of the new agricultural technologies amongst the famers of the district helps to increase the production of various agricultural items. Every year a huge chunk of revenue comes from the agricultural products in the district helps in its economy to a great extent. The district is scantily industrialised, only a few small scale industries of handicraft are present over there. The district is also rich in mineral resources. Copper, Magnetite, etc are the commonly found mineral resources in the district. Forestry is the extra source of income for the rural people of the district. In the year 2016-17 the gross domestic product in the district was Rs. 6,60,378 lakh at current price and Rs. 5,45,139 lakh at constant prices in the year 2011-2012. The net domestic product in the district during the period 2016-17 was Rs. 2,84,339 lakh at current price and Rs. 2,23,077 lakh at constant prices in the year 2011-2012. The Per Capita Income or NDDP, At Factor Cost in the district during the period 2016-17 was Rs. 96,786 at current price and Rs. 79,484 at constant prices in the year 2011-2012.
The district is well known as an abode of several reputed educational institutions. It provides a platform for higher education. Some of its recognised educational institutions are G.B. Pant institute of Himalayan environment and development, Vivekanand Hill Agriculture and Research, Govt. Girls Polytechnic college, Kumaun University campus of Almora, Govt. Law college, etc. As per 2011 census the literacy rate in the district is 80.47% including 92.86% are males and 69.93% are females. The total number of literates in the district is 4,36,497 out of which 2,31,604 are males and 2,04,893 are females.
Pandit Govind Ballabh Pant, a veteran Indian freedom fighter and politician who served as the first Chief Minister of Uttar Pradesh from 26th January, 1950 to 27th December, 1954 was born on 10th September, 1887 at Khoont in the Almora district. He was member of the Indian National Congress.
The district has several centres of attraction which allures many travellers from different parts of the country as well as world. Manila, a place located almost 85 km. away from Ranikhet in the district has the famous temple of Manila Devi, the family goddess of Katyuri kings. Literally the term "Manila" means enchanting. The surrounding forests and the Himalayan views create mesmerising scenery in this place. Katarmal, situated at a distance of 17 km. in the north western part of the Almora is famous for the 800 years old temple of Sun God. After the Konark temple in Puri at Orissa, it is the only Sun temple in India. Jalana, situated almost 35 km. away from Almora offers a wide panoramic view of Himalayas and picturesque surroundings. This place is full of variety of fruits such as apricots, peaches, peers, plums and apples. Some other places of interest in the district are Ranikhet, Kausani, Binsar, Shitla Khet, Baijnath, Dwarahat, etc.
') ; // $('#ddlstate [value=0]').attr('selected', 'true'); }); //var scode = $("#ddlstate option:selected").val(); //$.ajax({ // type: "Get", // url: "/home/fillDistrict?scode=" + scode + "", // dataType: "json", // success: function (data) { // $("#ddlDistrict").empty(); // var s = 'Select DistrictAll District'; // $("#ddlDistrict").prepend(s); // for (var i = 0; i < data.length; i++) { // s += '' + data[i].value + ''; // } // String(s) // $("#ddlDistrict").html(s); // }, // error: function (data) { // alert(data); // } //}); function fncheckselectval() { //alert(); var txtSearch = $('#txtSearch').val(); var stateName = $("#statename").val(); var districtName = $('#ddlDistrict option:selected').text(); if (txtSearch == 'Search Key Word' && ($('#ddlDistrict').val() == 'Select District' || $('#ddlDistrict').val() == '0')) { alert('Please enter a keyword and select a state and a district'); return false; } else if (txtSearch == 'Search Key Word') { alert('Pease enter a keyword'); return false; } else if ($('#ddlDistrict').val() == 'Select District' || $('#ddlDistrict').val() == '0') { alert('Please select a district'); return false; } window.location.href = "/Home/SearchData" + "?keyword=" + txtSearch + "&stateName=" + stateName +"&districtName=" + districtName; return true; }
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text:
Photographer inspired by Hackney Gazette headlines like "For Batter For Worse" brings out book
By Emma Bartholomew
Published: 7:39 PM October 23, 2012 Updated: 10:33 AM October 14, 2020
Renowned photographer and Hackney Gazette fan Tom Hunter - who has used the local rag as inspiration for much of his work - has finally published a book of the work he's created over the last 25 years.
The Way Home tracks his collections from The Ghetto when he lived in a large squatting community around London Fields, to the first and only ever exhibition of photography held in the National Gallery, based on Hackney Gazette stories, which immortalised headlines like "Living in Hell" about a sofa-bound woman, and "For Batter For Worse" depicting a fight during a wedding on the Town Hall steps.
It also portrays more recent work like the series commissioned by the Royal Shakespeare Company, in which he bases the play A Midsummer Night's Dream in the borough.
Pearly kings and queens became the royalty, Tropical Isles samba dancers turn into fairies, "lovers" are plucked from Mossbourne sixth form, and a stripper was thrown in for good measure to represent the exotic.
"It is this mixing of cultures, architectures, people and histories that has so captivated me and held me in the arms of Hackney," says Tom in the introduction to his book.
"Every building has a thousand tales to tell and in this book I've tried to tell a few."
Tom now teaches MA students at the London College of Communication in Elephant and Castle, but at the outset of his photography career he would scour the Gazette's jumble sale listings to buy nick nacks he'd sell on at a stall in Brick Lane to fund his college studies.
"Like Vermeer I have concentrated on my local area and in this book I've tried to show my journey home to where I live," explained Tom.
"Although I have not repeated directly referencing Vermeer in my work since 'Persons Unknown' I have always tried to keep his art practice at the core of all my work.
"Whether I'm taking photographs of the residents of condemned tower blocks, shopkeepers, barmaids or the disenfranchised, this way of working has shaped nearly every photograph I have ever taken since this time."
Tom is giving a talk and signing copies of his book at the Photographers Gallery, 16-18 Ramillies Street near Oxford Circus on Thursday November 8 from 6pm to 7pm.


text:
Q: Meaning of 'to break down the barriers' From the article:

It still remained a mystery why it had happened.
  There was a wall of secrecy surrounding the whole affair which it was
  virtually impossible to break through. One reporter on the local paper
  however was determined to break down the barriers and get to the
  bottom of the matter.

I'm a little confused by the meaning of break down here. I'd say that it has something to do with starting communicating with people involved in the affair and put out some details about it.

A: Not sure if break down is really being used phrasally here ...
You can add a preposition after a verb to indicate the direction that the activity was pointed toward.  This can overlap with phrasal verbs.

I threw down the ball to Jimmy = I threw the ball in a downward direction to Jimmy, Jimmy is below me.

And sometimes the direction of the activity is specified but the subject of the activity is not directly "aiming" the action:

We broke down the wall = We destroyed the wall.  We didn't necessary apply force in a downward motion but when a wall breaks it will fall down to the ground by itself.

But break down can be used to describe destruction for things other than walls:

Relations between the US and North Korea broke down.

It also can be used to not necessarily mean "to be destroyed" but something like "remove".  So barriers in the sense of things that block communication are a logical type of wall and to "break them down" means to find a way through the barrier.
It also can mean to take apart in preparation to be put away:

The carnival ended, the workers broke down the tent and later loaded it on a truck.

A meaning of break down that is not related to the above, where it 100% is a phrasal verb, means to reduce to smaller parts, typically to try to understand.

This is a complicated topic, let's break it down into simpler concepts so we can understand.

A:
Here is the definition of break down; Suddenly cease to function.

So when a wall gets destroyed or falls down it, suddenly ceases to function.

But in this case they are talking about a figurative "wall"

One reporter on the local paper however was determined to break down the barriers and get to the bottom of the matter.
So that reporter was trying to break down this figurative wall of secrecy so that whatever the "wall" was hiding or protecting would be exposed.
Also understand a walls function is to hide or protect something,
So when it ceases to function that "wall stops hiding and protecting therefore exposing what the reporter is trying to expose by breaking down the wall.


text:
Minor MLB Transactions: 11/7/17
By Jeff Todd | November 7, 2017 at 8:36am CDT
After a busy transactional day yesterday, let's catch up on some of the latest minor moves:
Catcher Bryan Holaday and outfielder Alex Presley have elected free agency from the Tigers, Evan Woodberry of MLive.com reports on Twitter. Each of the veterans was outrighted recently, though Woodberry hints that Detroit has interest in bringing both back on minors deals. Holaday will enter the pool of catchers that are looking for opportunities to compete for reserve jobs in camp. The 32-year-old Presley should also draw attention from other organizations; he turned in 264 plate appearances of .314/.354/.416 hitting in 2017.
The Rockies selected the contract of outfielder Noel Cuevas, per a club announcement. Acquired from the division-rival Dodgers in the trade that sent Juan Nicasio to Los Angeles, Cuevas blossomed at Triple-A Alburquerque in 2017. Across 528 plate appearances, he posted a .312/.353/.487 slash with 15 long balls and 16 steals.
Two players were also added to the Yankees 40-man roster, the club announced. Outfielder Jake Cave is one of them; the one-time Rule 5 pick won't be eligible for the draft again this year. He turned in a compelling season in the upper minors, including a robust .324/.367/.554 batting line with 15 long balls in 297 Triple-A plate appearances. Joining him is righty Nick Rumbelow, who returned from Tommy John surgery with aplomb last year. Over 40 1/3 innings, he allowed just five earned runs on 21 hits while racking up a 45:11 K/BB ratio.
The Indians selected the contract of Eric Haase, per the MLB.com transactions page. The 24-year-old backstop knocked around Double-A pitching to the tune of a .258/.349/.574 batting line and 26 homers through 381 plate appearances.
Cuban catcher Lorenzo Quintana is joining the Astros for a $200K bonus, per MLB.com's Jesse Sanchez (via Twitter). The 28-year-old is not subject to international signing restrictions. Quintana was long one of the most productive receivers in Cuba's Serie Nacional, carrying a lifetime .310/.377/.438 batting line, but he last played there in the 2014-15 season.
Cleveland Guardians Colorado Rockies Detroit Tigers Houston Astros Los Angeles Dodgers New York Yankees Transactions Alex Presley Bryan Holaday Jake Cave Juan Nicasio Lorenzo Quintana Nick Rumbelow
Outrighted: Twins, Phillies, Rays, Cardinals, Padres, Dodgers, Pirates
Curtis Granderson Intends To Play In 2018
davidcoonce74
Presley turned in a surprisingly good offensive season for a team to just release him. I understand he's just a singles hitter, basically, but is his defense just that bad that he's not even rosterable?
diller79
The tigers are just trying to get younger and Presley is over 30 and they would rather have a younger player in that roster spot
bastros88
that's always been the case for Presley, always serviceable, but always cut for reasons that I will never understand
Michael Chaney
I've been a little intrigued by Haase for a while. He doesn't get a lot of prospect attention and he's probably a first baseman long term so who knows if the bat can play, but he wasn't a high draft pick and all he's done since then is hit. I met him last year with Akron too, and he's a really good guy.
Siriusrooney
Nice to see Cave getting some recognition. He had a great season in the minors and hope he take it to the next level. At the very least he is good trade piece to have
Interesting pickup in Quintana. Could be a candidate for #2 catcher behind McCann next year if Gattis moves to DH full time. Or just may be good AAA reserve assuming either Centeno or Stassi will be released or traded.
Pirates Outright Miguel Andujar
Red Sox In Talks With Roberto Perez


On behalf of Law Office of Stuart E. Bruers posted in Child Support on Tuesday, March 26, 2019.
After almost five decades of being divorced, a woman will finally be receiving support from her former husband for their now adult child. The California resident successfully sued her former husband for child support he owed for their 52-year-old daughter who was 3 at the time of her parents' divorce. The man apparently fled the country in the 1970s rather than make support payments.
The woman worked to put her now successful daughter through college, but as older age approaches, she says the money has been tight. She said when she realized there is no statute of limitations on child support, she decided she would try to get her former husband to pay up. The man was ordered to pay $160 a month more than 50 years ago, but with interest added at 10 percent per year, that amounted to $170,000 in back payments.
The court agreed to a settlement of $150,000. There has been no feedback from the woman's former husband, who currently resides in Oregon. The woman says she wants other women whose former husbands aren't or haven't paid support to know that they can sue for back payment even after many years.
There are some laws of which many people are unaware when it comes to child support issues. A California lawyer may be able to review a client's individual case and make recommendations when it comes to child support orders not being followed. The law states that children should have the support of both parents and in many cases, that means financially as well.
Related Posts: New bill will assist in child support collection, California child support considerations, Child support often misunderstood and misused, How is child support calculated?


Nurse Next Door has had success in markets both big and small across the country. Initially a Vancouver start-up founded by Ken Sim and John DeHart, the organization is now one of North America's fastest growing home care systems with 160+ franchise locations.
While some of our Franchise Partners are in the healthcare industry, 75% of them come from non-medical backgrounds and we love sharing success stories like Peter Coulter, Nurse Next Door business owner in Comox, British Columbia.
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Peter operates a Nurse Next Door franchise in Comox, British Columbia (population 13,627). He sees the small population as an opportunity rather than a limitation. "Small-town mentality can pay in dividends," says Peter. He credits his familiarity with the needs of his community as one of the keys to his success.
It's not always easy, but with creative thinking and research, small-town business owners can thrive while doing rewarding work.
Business owners can save on advertising dollars with word-of-mouth promotion and a strong referral network. But ads also typically cost less in small towns, and fewer media channels can mean reaching a bigger percentage of the local population.
Though Peter acknowledges the challenges of a small population when hiring, he says choosing your team carefully can make a world of difference. "When there's a good management team in place, there's a good work-life balance," he says. Peter insists that taking the time to build a supportive workplace culture is worth the effort. "Take time to nurture trust and loyalty," he adds, in order to hold on to your best employees when you're working with a small talent pool.
"Do your homework! It's important with any business, but it's vital in smaller communities." Peter believes that knowing your community and supplying for demand can be the catalyst for success. If you're in the home care industry, set up shop in a town with lots of retirees and talk to people about their needs and expectations.
As a business owner, understanding your community's demographic needs will help ensure your success. But the best way to learn about your community is to get involved. For example, Peter runs fundraising programs that benefit the local hospice society, as well as the Heart & Stroke Foundation. He's giving back while getting to know other volunteers and participants.
Do you know someone that could be our next success story, like Peter? Learn more about Nurse Next Door's Canadian referral franchise program and how you can earn $10k, click here for all the details — let's chat!


I've had a few K185 Carhartt sweatshirts in the past. This Paxton Heavyweight replaced it. I prefer the extinct K185 over the Paxton for a few reasons. First off, I'm tall (6'3") and lanky. I've always had trouble finding sleeves that are long enough. On my 2XLT Paxton, the sleeves are slightly shorter than the K185 it replaced...to a point where I'd be afraid to throw it in the dryer out of fear of it shrinking. The body fits well enough, though, with just the right amount of extra room. Worth noting, and not to say that I can feel the difference, but the K185 was 80/20 cotton/poly. Carhartt lowered the Paxton cotton content to 75/25. Last, but not least, is a small gripe. On the left sleeve near the wrist cuff, there's some sort of heat applied decal that reads "Rain Defender." It's not removable, and there for keeps. To me, this is the equivalent of a non-removable decal that reads "Double Stitched." As a grown man, I don't need features permanently printed for all to see on any article of clothing.
Gift for my hard to buy for husband. He liked it!
Warm and fits great. Wear it all the time.
Bit shorter than midweight hoodie in overall length, so it's makes better fit than midwight hoodie of looking like wearing daddy's big clothes.Pretty warm in chilly weathers, but it doesn't have protection for neck area, so better wear inner shirts or sweatshirts in extreme conditions.
It's awesome looks great and it's just what I was looking for.


Harrington Starr are pleased be partnered with one of the largest technology providers in the UK. Specialising in data analyses and analytical reporting solutions for the buy side, my client is now look to add a senior Account Manger into its team, to help support future growth.
The Account Management team is critical within the business. This team specialises in Prime Brokerage products, Hedge Fund and Asset Manager Treasury needs.
Responsible for maintaining and broadening client relationships across designated client accounts, across the Hedge Fund Community based in London and across the UK.
Upsell clients with additional products, tools and features as well as target to increase the annual contract value.
Experience selling into the Hedge Fund Community – is essential.
Excel skills helpful, basic SQL ideal although not essential.
Work in a large market sector with huge potential for growth.
Work as part of a talented team that has an excellent track record of achievement and reward.
Strong Company brand name to leverage from.


text:
Q: How to use a new movieClip as a Class or to copy it without reference to its class? I am doing a looping background with 2 identical BG movieClip (B1 and B2). Those 2 are "new" by the same class.
var B1:MovieClip = new BG();
var B2:MovieClip = new BG();

But because this BG class picture is loader from the internet and the picture is rather big. When I addressed its loading by using progressEvent. The picture is really loaded 2 times. Is there anyway I create B2 based on B1 without using new BG() again? Since it definitely makes a new BG with Loader code inside.
Thank you for your help ^^
For BG class code:
var URLvar:URLRequest;
var BGLoader : Loader = new Loader( );
URLvar = new URLRequest( "somewherelink.jpg" );
BGLoader.load(URLvar);
this.addChild(BGLoader);

is there any way that I set if the B1 is completely loaded, I copy it into B2? or any other way to achieve the same goal?
import flash.display.*;
import flash.utils.*;
var obj:Class = getDefinitionByName("bluebox") as Class;
addChild(MovieClip(new obj()));

I found this one in a dynamically Create Class, but I dunno how to use T_T, can you explain it to me and can I use it in this situation?
Thank you for your time ^^

A: For this answer I'm going to assume that you are always going to want to have the same image twice, rather than two different ones.  The problem you have is that your BG class does the load and the attach completely internally.  My preferred approach would be to load once, and then create to instances of the loaded content.
//first lets create a single loader
var bgLoader:Loader = new Loader();
bgLoader.contentLoaderInfo.addEventListener(Event.COMPLETE,completeHandler);
//and load the content
var urlVar:URLRequest = new URLRequest("somewherelink.jpg");
bgLoader.load(urlVar);
//notice that we don't add the loader to the stage

function completeHandler(evt:Event):void
{
    //remove the loader listener for memory conservation purposes
    evt.target.removeEventListener(Event.COMPLETE,completeHandler);
    //reference the content
    var content:DisplayObject = evt.target.content;
    //so now create a bitmapData object
    var bmd:BitmapData = new BitmapData(content.width,content.height,false); // use (content.width,content.height,true,0) if loading image with transparancy
    //and draw the loaded image into to bitmap data
    bmd.draw(content);
    //now you can create as many Bitmap objects from this data as you like
    var bg1:Bitmap = new Bitmap(bmd);
    var bg2:Bitmap = new Bitmap(bmd);
    //offset bg2 so both are visible
    bg2.x = 100;
    addChild(bg1);
    addChild(bg2);
}

For your second question... getDefinitionByName returns you an object that represents a named class, rather than an instance of it.  So in your example, it is getting a definition for the class 'bluebox', which is in the root of your application source (not in a folder).
Once you have that class object you can create instances of it with the new keyword. The big disadvantage of this as far as I'm concerned is that you don't import the class, hence in your example obj is cast as a MovieClip.  That makes features of code editors like code completion and error highlighting to not work correctly because the properties and methods of 'bluebox' are not exposed.
I usually only use this for creating objects that will have their classes defined elsewhere, in an XML file that is loaded at runtime for example.

A: If the URLRequest URL is the same for both the browser will serve up a cached version the second time around.  The request is made to the browser twice, but only once to the server.  You can use an http sniffer like httpfox, charles or fiddler to validate the requests.


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Selecting a MATLAB Application Deployment Strategy
By Dr. Titus Edelhofer, MathWorks
You have a wide range of options for deploying and sharing an application developed in MATLAB®. One of the most straightforward options is to package individual algorithms and applications into a single file and distribute the file to other MATLAB users. However, in many situations this simple approach is not practical. Production requirements, the IT landscape, or performance needs may call for a more advanced deployment strategy.
This article guides you through the process of selecting the best deployment approach for your MATLAB application. It covers the three main strategies available: using batch processing to deploy MATLAB code directly, generating C code with MATLAB Coder™, and deploying with MATLAB Compiler™.
This overview of deployment strategies is by no means exhaustive. There is no one-size-fits-all strategy, and it is important to thoroughly analyze your requirements before choosing a strategy to meet them.
Application Structure: Front End and Back End
Before considering a deployment strategy, it is important to understand the structure of your application and how it affects the options available. All MATLAB applications consist of two parts: a front end and a back end. The front end is the part that the end user interacts with. It is the interface or the web page, usually consisting of control elements (including buttons and boxes where the user can type numbers or other information) and display elements (including tables and graphs).
The back end is the computational engine that computes results and produces the graphics to be displayed. The back end and front end in combination govern your options for deployment. Since the deployment of a MATLAB based front end is fairly straightforward, this article will focus on options for back-end deployment.
Deploying Native MATLAB Code to Other MATLAB Users
There are two basic strategies for deploying uncompiled MATLAB code: use MATLAB as a batch processing engine, or use MATLAB Parallel Server™.
Using MATLAB Batch Processing
One advantage of the batch processing approach is that it's easy to implement—updating the server code is a trivial task. However, its scalability is limited, so it may not be suitable for processing multiple concurrent requests. This approach also requires a concurrent network license for MATLAB since the batch processing is not bound to one specific user.
In MATLAB batch processing, MATLAB is used, not as an interactive environment, but as a process to execute a single command or, for more complex calculations, a script containing a sequence of commands. The process that invokes MATLAB (typically, the front end) must be able to launch an external program (in this case, MATLAB) on the same machine. Specifically, the invoking process launches MATLAB using the "-r" command-line option. The command matlab -r "statement" will start MATLAB and execute the specified MATLAB statement, which can be a MATLAB function or script. For example, the following statement could be used to start batch processing of a file named blackscholes.m located in a directory in the MATLAB search path:
matlab –r "blackscholes;quit"
The blackscholes.m script performs any steps needed to complete the batch processing, such as reading parameters or data from a file or database, computing results, and saving the results to another file or database.
In practice, a more advanced command is used to handle errors and suppress unnecessary visual elements:
matlab –nodesktop –nosplash –wait –r "try,blackscholes;catch,end;quit"
Batch processing is suitable when a simple call to an external executable is sufficient to complete the processing and high availability is not a strict requirement. Note that there is little benefit to using this approach when you intend to use MATLAB for the front end as well, because it would involve starting a second instance of MATLAB with another license.
Using MATLAB Parallel Server
Whereas batch processing simplifies the execution of uncompiled MATLAB code on the same machine as the front end, MATLAB Parallel Server makes it easy to offload computationally intensive MATLAB code from the desktop to a server environment. With MATLAB Parallel Server, you can run computationally intensive MATLAB applications on computer clusters or on Amazon EC2. This approach supports applications that require parallel computing and processing of large data sets stored in distributed arrays. Because MATLAB Parallel Server provides licenses for MATLAB toolboxes, you can execute MATLAB applications on a cluster without acquiring product-specific licenses for each computer.
The typical workflow is as follows: Starting with Parallel Computing Toolbox™, prepare the code for parallel execution using parfor or jobs and tasks. Once the code is running in parallel as expected—excluding performance considerations—to prepare the code to run on the MATLAB Parallel Server cluster you do not need to make any code changes; it is merely a question of using another configuration.
Generating C/C++ Code
MATLAB Coder can be used to generate self-contained, deployable C/C++ code. The generated ANSI/ISO compliant C and C++ code does not depend on static or dynamic libraries or run-time environments provided by MathWorks; it can be used on any platform that provides a suitable C/C++ compiler. This approach is recommended when the target deployment platform is not supported by MATLAB—such platforms include embedded systems and platforms such as AIX or IRIX. For these platforms, you can generate C/C++ code that is integrated into a larger application or invoked as a shared library.
A principal drawback of this approach is that MATLAB Coder supports a subset of core MATLAB language features—including program control constructs, functions, and matrix operations—but not all functionality that MATLAB and related toolboxes provide. See MATLAB Language Features Supported for C/C++ Code Generation.
Deploying with MATLAB Compiler
MATLAB Compiler enables you to deploy MATLAB programs as standalone applications or as shared libraries (.lib or .dll files). Applications and libraries created using MATLAB Compiler rely on the MATLAB Runtime, which enables users to run compiled MATLAB applications without installing MATLAB. MATLAB Runtime can be packaged and installed with your application or downloaded during the installation process. Because you can freely distribute MATLAB Runtime, MATLAB Compiler enables you to run multiple instances of your code without acquiring additional licenses.
Code produced by MATLAB Compiler and processed by MATLAB Runtime is an intermediate (encrypted) representation, comparable to .class files in Java®—it is not machine code. MATLAB Runtime interprets this intermediate representation using the same engine that MATLAB uses to process standard MATLAB scripts and commands.
You can use MATLAB Compiler to deploy MATLAB code as a standalone Windows application, a shared library, an Excel® add-in, a .NET assembly, or a generic COM component, among other options (Figure 1).
Figure 1. MATLAB Compiler options for deploying an application.
Creating a Standalone Application
The simplest way to deploy code with MATLAB Compiler is to generate a standalone application. It is possible to generate an application with a built-in interface (front end) or one that is intended for use solely as a processing engine. Standalone applications intended for use as processing engines are similar to uncompiled MATLAB applications used in batch processing in that they are invoked by a front-end process that may pass parameters via the command line.
The advantage of this approach is that, apart from the MATLAB Compiler license, no additional licenses are required—you can distribute the application and run it on systems that do not have MATLAB installed. One limitation of this approach is that it is more difficult to debug compiled applications than MATLAB scripts. Input parameters provided to the MATLAB code must be passed as strings, which makes it difficult to exchange complex data sets between the front end and back end. For large or structured data, it is best to use a file-based data exchange mechanism based on XML, comma-separated values (CSV), or MATLAB files.
To start the compilation process, you invoke the Application Compiler from the Apps tab in MATLAB. The compiler automatically detects dependencies on other MATLAB functions and adds them during the compilation process. You only need to add dependencies not detected by the compiler, such as data files or images.
Creating a Shared Library
You can also use MATLAB Compiler to create a C or C++ shared library (for example, a .lib or .dll file). This enables an in-process approach in which the library and the code that invokes it are part of a single operating system process. In contrast, the previous section described an out-of-process approach involving two separate operating system processes. To use the shared library approach, your front end must be able to call into an external library using a C wrapper interface.
The advantage of calling a function in a shared library instead of invoking a standalone executable is that passing parameters is much easier, especially when the data sets are structured or large. Using the MATLAB C API, you can structure the data as a matrix, cell array, or structured array, among other data types. To access the results, the calling application extracts native C data from the structures provided by the API.
Creating a Java Component for an Application Server
When you deploy your MATLAB program as a web application or as an application server component, authorized users can access it via a web browser. A principal advantage of this approach is that it obviates the need to develop and maintain client software and install that software on each user's computer. MATLAB Compiler SDK™ work with MATLAB Compiler to create software components that can be deployed to application servers and as web applications.
Follow these steps to deploy a MATLAB application to a Java-based application server:
Compile the MATLAB application into a Java ARchive (JAR) or Web application ARchive (WAR) file using MATLAB Compiler SDK. MATLAB Compiler SDK generates a wrapper Java class that calls the compiled code.
Install the Java class and the MATLAB Runtime on the application server.
Creating a .NET Assembly for an Application Server
The Microsoft analog to Java-based application servers is Internet Information Services (IIS), formerly Internet Information Server. You can use MATLAB Compiler SDK to generate a .NET or COM component from your MATLAB code, and then deploy IIS for use with ASP.NET applications. The components you generate can be invoked from any language that complies with the Common Language Specification, such as C#, VB.NET, and ASP.NET, as well as any software technology capable of accessing a COM component, including Visual Basic®, ASP, and Excel.
Web Deployment
The workflow for Web deployment is similar to the workflow for application server deployment described for both Java and .NET. You use MATLAB Compiler SDK to compile your MATLAB code into a Java or .NET component, which then is invoked by the web server. You can use the Web Figures interface to display interactive graphics on the web page without installing any client-side software or plug-ins.
MATLAB Production Server
Compiled MATLAB code running on an application server can reliably and quickly process requests as long as the number of concurrent requests remains low. For large numbers of concurrent requests, however, performance can become an issue for an application server running compiled MATLAB code. At RWE, for example, developers used MATLAB Compiler SDK and MATLAB Compiler to build a Java component for an automatic natural gas pricing and risk management system. To enable the system to handle many concurrent requests, the developers added a layer between the application server and the compiled MATLAB code. In this layer, a system of redundant RMI servers concurrently serves the main application server in parallel. However, implementation of such a layer is a non-trivial task.
To handle many concurrent requests without developing your own middleware solution, you can use MATLAB Production Server™. Simple to administer, MATLAB Production Server is both scalable with respect to concurrent requests and fast (with low latency).
Scalability is achieved by having multiple MATLAB Runtime instances (or "workers") running and ready to respond to requests from the server. For added reliability and scalability, multiple instances of MATLAB Production Server can be combined. The workers are shared among instances to maximize performance and minimize response time. A load balance responsible for accessing the different MATLAB Production Server instances (Figure 2).
Figure 2. Multiple MATLAB Production Server instances serving an enterprise application with a load balancer.
MATLAB Production Server and Microsoft SQL Server
In addition to the relatively straightforward case of using MATLAB Production Server as a computational back end for an enterprise application, there is a special situation in which the client system is a relational database—specifically, Microsoft® SQL Server®.
Within stored procedures, Microsoft SQL Server is capable of calling external code using the .NET framework. In doing so, the database may fill columns within a table by calling an external .NET component. Using the .NET client API, such a component may call into the MATLAB Production Server synchronously to retrieve computed values (other columns of the table may be used as input to the computations).
For this setup, when rows are added to the table, only those columns that contain the necessary data are filled. Others columns are filled by the MATLAB based back end.
Selecting the Right Strategy
As was pointed out at the beginning of this article, no single deployment strategy fits every possible scenario. Begin by selecting a strategy that fulfills your highest priority requirements. You can then develop a more detailed solution that addresses all your organization's needs.
Dr. Titus Edelhofer is a senior team leader in MathWorks Consulting Services. He works with companies in the finance, energy trading and production, and automotive industries on a wide range of applications to automate business processes, reduce development time, and integrate MATLAB solutions into business-critical applications. Titus holds an M.S. and a Ph.D. in mathematics from the Technical University in Aachen, Germany.
Published 2014 - 92230v00
MATLAB Coder
MATLAB Compiler
MATLAB Compiler SDK
MATLAB Parallel Server
Sharing and Deploying MATLAB Applications (26:14)
RWE Develops and Deploys an Automated System for Natural Gas and Power Trading and Risk Management
MathWorks Consulting Services
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Robotic automation is one of the hottest investment growth areas as seen with the spectacular rise of the Blue Prism (LSE:PRSM) share price which has increased over 1,500% in five years. I called out this share price as unrealistic in September and it has fallen around 40% since then. Most of this fall is due to the weak market but the most hyped shares appear to have been suffering the most.
Blue Prism has a very exciting product as indicated by its excellent customer retention with recurring licence revenue making up 93% of its total….
Blue Prism has a very exciting product as indicated by its excellent customer retention with recurring licence revenue making up 93% of its total. Forecast revenue growth is massive, at around 50% for the next couple of years. It has also been beating expectations which I like to see.
However the scale of the upside has attracted a lot of gamblers. At the time of writing, the share price has just gained 10% in one day after losing 10% yesterday. With such high volatility, entering at this stage is tantamount to gambling unless you can realistically assess what the business is worth. The company is releasing a trading update on Tuesday and recently these have been very positive causing surges in the share price.
Last week the chairman announced he was leaving the business to focus on other companies. I find it odd that he would leave if he thought the firm could become one of the biggest in the UK. It's easy to forget how small this company still is and how much has to go right for it to be worth its current price.
The company is burning through cash to achieve its growth and it's very difficult to assess how profitable it will become. I can understand the bull case for this share, but I don't think even the best companies should be bought at any price. Even after this fall the price is still supported by hype which can easily collapse, so I'd stay away.
Fevertree Drinks (LSE:FEVR) has also been on my radar for a while. It has a lot of similar attributes to Blue Prism with rapid international growth, regularly exceeding expectations and an enormous valuation.
But it also offers what I think are exceptional quality metrics. These indicate how effectively it can generate profits on revenues and reinvested capital and are often over looked by new investors but are very important pointers to how quickly a company can grow. Fevertree has an operating margin of 32% and a return on reinvested capital of 44%, which is a powerful cocktail.
I particularly like the brand, which I think still has a lot of room to expand in the international market that currently only makes up 44% of its revenue. Its biggest focus has been the UK so far, but the gin trend is an international phenomenon, so there is great opportunity for global growth.
Any mention of Fevertree will include valuation at some point. With a price-to-earnings ratio (P/E) of 47.2, it's not cheap. But you don't expect to pay low prices for the best products. Fevertree has frequently traded at a P/E of above 100 and has never traded below 40. We may be in a bear market, which means the old rules will no longer apply but this is a share that I'd like to own, and at this price I'd be tempted to buy.


That's right, folks. When Doctor Dunce is caught (yet again) talking crap, pay it no mind. You have your instructions.
Try starting by getting the facts right, Doctor Femano.
We note the informal diminuitive "glyphs", conveying the message that Doctor Femano has an easy familiarity with (and facile competence in) these matters.
I challenge the claim. Cite the specifics, Doctor.
> I'm simply trying to understand . . .
I've noticed, Doctor Femano, that when you employ such phrases as "I'm only" or "I'm simply", what follows is reliably a lie.
> . . . what the translation luminaries believe . . .
> . . . are the connotations . . .
I challenge the claim that "we" see any such thing.