text:
So... If you could only choose 3 all-time favourite video games, which would they be and why?
Swoopingisbad
Games: Dragon Age: Origins, Dragon Age 2, Dragon Age Inquisition, Baldur's Gate
Posts: 606 Likes: 1,100
Sept 24, 2018 14:34:18 GMT
Dragon Age: Origins, Dragon Age 2, Dragon Age Inquisition, Baldur's Gate
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 18:46:30 GMT Kroitz likes this
Post by Swoopingisbad on Oct 4, 2018 18:46:30 GMT
I know, I know, it's a really though question but I thought it could be really interesting. For me, as I am a quite emotionally driven person, my prefered video games are those that moved me, for many reasons.
My choices would be, I think, in no specific order (I'll try to keep it short):
Zelda Ocarina of Time. I think it's the first, or one of the first, video games I ever played. So many good memories. I used to play it with my father and brother. It's the video game that first introduced me to the gaming world.
I remember everything very fondly and with so much nostalgia; the amazing exploration, the impressive soundtrack, immersive sound effects, the exciting adventure… And the cuccos
Silent Hill 1 or 2. I'll choose the 2nd, I think. Both are great tho. Excellent soundtrack and atmosphere. The best horror game, imho. Both have an amazing story but, I don't know, I get very emotional with Silent Hill 2, Mary's letter gets me every time. Plus the symbolism in Silent Hill 2 is brilliant.
Dragon Age Origins: It's almost the only game that I find myself going back to, many times, after so many years. It is endearing in its own way. It as an epic plot and very compelling and lovable characters.
Special mention to Shadow of Colossus, Metal Gear Solid (all the series is pretty great, apart from the 4th game), The Last of Us and Metroid Prime (I'll stop because I'll never end otherwise!)
themikefest
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So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 19:04:33 GMT Treacherous J Slither, Swoopingisbad, and 1 more like this
Post by themikefest on Oct 4, 2018 19:04:33 GMT
DAO because of the music
ME2 because I liked that Harbinger, ASSUMING DIRECT CONTROL, talked smack to my Shepard
God of War 2018 because....Kratos
Special mention to Pong.
Elizabeth Nancy Shepard - Earthborn/soldier/ruthless Humanity #1
I'm Commander Shepard, and this is my favorite playthrough in ME
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AnDromedary
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 19:10:03 GMT KrrKs, Kappa Neko, and 2 more like this
Post by AnDromedary on Oct 4, 2018 19:10:03 GMT
Star Trek The Next Generation: A Final Unity: One of my first games ever (so nostalgia bonus x 10 ). A fantastic take on the TNG universe and IMO an example of a perfect licensed game that takes the spirit of the original IP and translates it into game mechanics without changing it to accommodate some weird game design. When playing this game, you really felt like you were playing through a double (or maybe more like quatriple or so) episode of the series - and one of the best ones at that The storyline on its own was great, too.
I am still playing through this game again every now and then today, it aged pretty well IMO.
Mass Effect 1: I mean, the entire trilogy was a mile stone in gaming but despite its flaws (repetitive environments for side quests, the clunky MAKO, etc.) ME1 takes the cake just for introducing this phenomenal universe. I've never seen such a dense and well thought out scifi universe be implemented from scratch. Usually it takes a couple of implementations before a universe is really fleshed out but ME was incredible right out of the gate (if anything, it got more screwed up as the series went along). So the world building was fantastic but I also liked the gameplay itself. The combination of TPS and exploration gameplay, RPG mechanics and all the dialogues and decisions was perfect for me and I had never seen anything like this before. Add to that the atmosphere that came with the visuals. I remember standing on an uncharted ice planet for the first time in a white armor (maybe a liberator, it was early in the game and I wasn't leveled up much yet) and thinking "yea, this really looks like I am an astronaut on an extrasolar planet". Brilliant!
Note: DA:O, which came out just a little later did just as well (if not better) on the world building and story and such. The reason ME wins for me is that I like the shooter gameplay more than the tactical pause-based combat and that I like scifi more than fantasy. Close call though.
The Witcher 3: I was a fan of the Witcher series since day 1 but Witcher 3 really knocked it out of the park. There has been so much said about this game by me and others, it's no longer necessary to elaborate much on this one, I think. Suffice it to say that the amount of content, yet the level of detail that CDPR put into this title is downright astonishing. This game has a lot of objectively well designed features to it but even then, it manages to be greater than its parts. IMO it is correctly widely acknowledged as one of the best games ever made.
Last Edit: Oct 4, 2018 20:04:42 GMT by AnDromedary
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 19:21:48 GMT themikefest, CrutchCricket, and 1 more like this
Oct 4, 2018 19:04:33 GMT themikefest said:
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 19:28:08 GMT
Oct 4, 2018 19:10:03 GMT AnDromedary said:
Star Trek The Next Generation: A Final Unity: One of my first games ever (so nostalgia bonus x 10 ). A fantastic take on the TNG universe and IMO an example of a perfect licensed game that takes the spirit of the original IP and translates it into game mechanics without changing it to accommodate some weird game design. When playing this game, you through you were playing through a double (or maybe more like quatriple or so) episode of the series - and one of the best ones at that The storyline on its own was great, too.
My favorite Witcher was Assassins of Kings.
insert quote here
Oct 4, 2018 19:28:08 GMT Swoopingisbad said:
That's fair. I really do like the entire series and I think each part has their individual strengths and weaknesses. W3 just wins for me because I was so damn impressed at how much stuff they managed to put in while still maintaining that high a quality. That was a true masterstroke IMO.
PapaCharlie9
✜ Forge Mechanic
Games: Mass Effect Trilogy, Dragon Age: Origins, Dragon Age Inquisition, Neverwinter Nights, Mass Effect Andromeda
Mass Effect Trilogy, Dragon Age: Origins, Dragon Age Inquisition, Neverwinter Nights, Mass Effect Andromeda
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 19:39:17 GMT via Tapatalk Swoopingisbad likes this
Post by PapaCharlie9 on Oct 4, 2018 19:39:17 GMT
Skyrim: best balance of narrative and player agency so far, hasn't been dethroned. Plus, mods.
NieR Automata: You've heard of ludonarrative dissonance? This game is uniquely the opposite. Plus it mind f's you like you wouldn't believe.
OG Doom 1993: First immersive video game I ever played. The (literally) free hit that got me addicted.
Runner-up: OG Zork (1980 Atari), text only adventure. Progenitor of all puzzle and point/click adventures. I never did figure out what to do with the bell, book and candle — no game wikis back then!
Distant Runner-up: Computer Space, one of the first video arcade games. The local bowling alley had one. I had to beg my grandpa for quarters to play it. Good times!
Inquisitor: Is that innuendo?
Sera: No, it's at the front!
Cadian Guardsman
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Games: Dragon Age Inquisition
Dec 7, 2019 15:32:27 GMT
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Dragon Age Inquisition
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 20:04:12 GMT via mobile Swoopingisbad likes this
Post by Cadian Guardsman on Oct 4, 2018 20:04:12 GMT
Spider-Man PS4: Best game I have played this year.
God of War PS4: Because Boi!
X-Com 2: One of my personal favourite RTS squad games.
Cadia stands!
#Creed #Abaddonsucks #Cadiaforever
Aug 1, 2016 12:26:23 GMT @tzeenchianapostrophe said:
TES: Skyrim.
Oct 4, 2018 19:49:48 GMT PapaCharlie9 said:
Yes, it is a great game but I've never finished it (I played, and play, for many many hours tho, but I just get distracted with all the stuff and quests you can do that I never follow the main quest ).
Psychevore
Games: Mass Effect Trilogy, Dragon Age: Origins, Dragon Age Inquistion, Baldur's Gate, Neverwinter Nights, Mass Effect Andromeda
Dec 25, 2019 8:21:32 GMT
Mass Effect Trilogy, Dragon Age: Origins, Dragon Age Inquistion, Baldur's Gate, Neverwinter Nights, Mass Effect Andromeda
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 20:07:07 GMT saandrig likes this
Post by Psychevore on Oct 4, 2018 20:07:07 GMT
1: Football Manager.
Even though I hardly play it anymore, there's not a game or even a game series that comes close to the amount of time I put into FM and it's predecessor Championship Manager. It's really not even close. I started playing in like 1995 with Championship Manager Italia. That's more than 2 decades ago.
2: Mass Effect Trilogy.
3: Crono Trigger
colfoley
Posts: 9,798 Likes: 15,862
Aug 17, 2016 10:19:37 GMT
Post by colfoley on Oct 4, 2018 21:33:31 GMT
Dragon Age Inquisition: Terrific game. The best cast in gaming as well as the best music. Solid gameplay overall, the story was well executed and the RP elements allowed you a fair amount of control over what kind of character you wanted to be. (though it lacked the arc of Dragon Age 2). Yes it did have some flaws to it and some of its connections were lacking but overall probably the best package and value I've ever had in a game.
Ace Combat 5: This game is truly a classic and again has a thrilling politically relevant story, some truly outstanding moments, great music, and a great cast of characters.
Mass Effect 2: Great music, great cast...hmm I'm sensing a patern. Also as my first real RPG this did inform a lot of my expectations in the genre and it still holds up reasonably well.
(for my writing, posting chapters of my novel)
KingDarious BBB
Aug 12, 2016 4:21:50 GMT
kingdarious
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 4, 2018 21:37:35 GMT via mobile Treacherous J Slither likes this
Post by KingDarious BBB on Oct 4, 2018 21:37:35 GMT
Dragon Age Origins and Assassin's Creed 2 tied for 3rd.
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 6:57:39 GMT
Post by PapaCharlie9 on Oct 5, 2018 6:57:39 GMT
I meant to add that Read Dead Redemption 2 has the potential to dethrone Skyrim from my Ultimate Three. We'll have to see if they deliver what they are promising.
DragonKingReborn
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Dragon Age: Origins, Dragon Age 2, Dragon Age Inquisition, KOTOR, Mass Effect Andromeda
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 7:12:17 GMT Swoopingisbad likes this
Post by DragonKingReborn on Oct 5, 2018 7:12:17 GMT
The number of times Dragon Age Origins is appearing pleases me
Dragon Age Origins (KOTOR introduced me to Bioware (and I loved it) but this is where they really got me.
Civilization V...just one more turn
And going old, old school...Quest for Glory: So You Want To Be A Hero... <<-- start of an addiction right there.
Honourable mention is Batman Arkham City, because I'm a sucker for almost anything half decent that deals with superheroes and that game is well past "decent".
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dagless
Oct 28, 2019 10:13:22 GMT
Oct 6, 2016 16:12:02 GMT
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 8:05:03 GMT via mobile
Post by dagless on Oct 5, 2018 8:05:03 GMT
Tricky. I feel I should include an RPG, as these are generally favorite games, but somehow none quite make the list. So in chronological order:
1. Elite (BBC Micro, 1984)
When almost all other games at the time were just fun nonsense like Chuckie Egg and Frogger, Elite was utterly incredible. 3D space combat, trading, smuggling, bounty hunting, hundreds of systems, ship upgrades, docking, even missions and tough as hell aliens later on.
2. Resident Evil 1 & 2 (PlayStation, 1996/98)
Strangely, I didn't actually play all that much myself. I tended to be "copilot". Ie. watch my friend do all the zombie and monster killing, but we'd discuss puzzles, where to go, what to stash in the crates and piss ourselves at the voice acting. Happy days.
3. XCom EU/EW & 2 (PC, 2012-2018)
Probably my favorite current games. At least the ones I keep coming back to. Can't stop myself starting a new campaign every now and then, despite there being so many other games out there to play, or frankly other things to do with my time. So much time spent.
Last Edit: Oct 5, 2018 8:05:47 GMT by dagless
Andraste_Reborn
andrastereborn
Post by Andraste_Reborn on Oct 5, 2018 8:29:31 GMT
Hmmmmmm. If I can only have three ...
1. Baldur's Gate 2
2. Grim Fandango
3. Dragon Age: Inquisition
... so I'd have to say I'm on the right message board.
ergates
Games: Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, KOTOR, Baldur's Gate, Neverwinter Nights, Jade Empire, Mass Effect Andromeda
Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, KOTOR, Baldur's Gate, Neverwinter Nights, Jade Empire, Mass Effect Andromeda
Post by ergates on Oct 5, 2018 8:52:20 GMT
Complete and utter no-brainer for me.
As far as I'm concerned all three titles are the absolute pinnacle of excellence, replayability and just pure enjoyment. Sure there's loads more that I'd like to add if I was allowed to make a top-10 or top-20, but those three are the games I constantly return to, and I think it's safe to say that I've probably played all three at least once every year since the date I purchased them. DA:Origins remains my favorite video game - period; and the other two follow close behind.
Last Edit: Oct 5, 2018 8:54:01 GMT by ergates
Post by Elfen Lied on Oct 5, 2018 9:37:51 GMT
Kroitz
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 11:09:38 GMT leadintea likes this
Post by Kroitz on Oct 5, 2018 11:09:38 GMT
Zero Escape Series. Scenario, layered twists, overarching plot and the characters had me entranced and shackled to my Vita. I can't ommit a series from a personal list of favorites, while I own it on almost every platform it released.
Well, since it's a trilogy my 3 spots are occupied. But ...
Dark Souls 3. Even if I like a directly told story, I'm also fond of an approach that avoids to interrupt the flow of gameplay. If it weren't for the tighter exploration and exhilarating combat I would give this spot to Breath of the Wild, however Dark Souls 3 just has the edge of doing what BotW does, but with more focus and challenge.
Street Fighter 5. Specifically the current AE edition, future updates included. Over 6K matches and countless hours played, it is my No.1 go to time-sink even 2 years after release.
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 11:49:33 GMT Elfen Lied likes this
Post by ergates on Oct 5, 2018 11:49:33 GMT
Given the amount of love shown for Dragon Age Origins in this thread and others (a love I totally share), if I were a developer I'd be thinking: "Hmm, it does seem self evident that a lot of people do prefer this particular style of game. Would it not make sense for us to explore this in relation to future projects?"
I doubt that Bioware can now be shifted from their no-holds-barred path of pseudo-open-world, multiplayer-focused, console-focused action/RPG releases; but surely a developer with a somewhat more flexible ideology must see the potential for another deep, immersive single player Western RPG that isn't just five hours of main plot padded out with a zillion fetch quests and collectibles.... No?
CitizenChris
Games: Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, KOTOR, Jade Empire
Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, KOTOR, Jade Empire
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 12:01:07 GMT PapaCharlie9 likes this
Post by CitizenChris on Oct 5, 2018 12:01:07 GMT
The first NieR hits the same notes as Automata but it does it a lot better with more engaging and fleshed out characters. I'd recommend playing that one if you liked Automata.
CrutchCricket
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Games: Mass Effect Trilogy
Feb 21, 2019 15:55:45 GMT
Post by CrutchCricket on Oct 5, 2018 12:22:02 GMT
I'm going to loophole the hell out of this question. Doing it by platform, and doing series instead of single games.
Half-Life series (includes G-Mod)
Dishonored series
God of War series (yes, include those later titles not on PS2 )
Metal Gear (yes, include those later titles not on PS2 )
GTA (yes, includes... you get the idea)
Multiplatform (because fuck it, that's a category now too)
Mortal Kombat (especially 9)
Doom (especially Doom 3) (it's on xbox and shit, it counts)
Also FEAR, Crysis and Elder Scrolls, because at this point, why not?
Be seeing you.
quizolio
Post by quizolio on Oct 5, 2018 12:48:14 GMT
Nov 10, 2016 16:47:07 GMT AnDromedary said:
Pretty much this for ME1.
My other two picks:
Doom (Series): Its Doom, not much else needs to be said. The OG titles kicked off a genre and are still good fun today, Doom 3 took things into an interesting turn and the 2016 game is my current contender for best game of this generation so far.
Metro 2033 (Redux): The atmosphere, gameplay and setting all combine to make a superb title. Just like the book it should be experienced at least once, especially considering the next entry which is coming next February and has the potential to be the best of the trilogy. Its bleak, dark and pessimistic, all the things a post-apocalyptic story needs.
Oct 5, 2018 12:48:14 GMT @quizolio said:
Doom (Series)
Great game indeed, the best of its kind, I would say. But I'm usually very bad at FPS games (I mean it, I suck so bad). I like them, but I get very frustrated when I play them .
UEG ShadowAngel
#more Asari
Games: Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, Jade Empire, Mass Effect Andromeda
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uegshadowangel
Mass Effect Trilogy, Dragon Age: Origins, Dragon Age 2, Dragon Age Inquistion, Jade Empire, Mass Effect Andromeda
So... If you could only choose 3 all-time favourite video games, which would they be and why? Oct 5, 2018 14:05:25 GMT via mobile
Post by UEG ShadowAngel on Oct 5, 2018 14:05:25 GMT
So many games that it's hard to pick then individually 🤔
Halo combat evolved, mass effect one, Oblivion, star craft, age of empires, JakII, dragon age origins, D@DO, etc etc. So many to pick I don't think I could do a top 3, furthermore I'm sure I could rotate it every time I'm asked.
~Give me ten minutes and I could start a war~


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↪ § 47–2008. Rules and regulations.
The Mayor is authorized to promulgate such rules and regulations as may be necessary to carry out the purposes of §§ 47-2006 and 47-2007.
For temporary (90 day) repeal of section, see § 12(yy) of Tax Clarity and Recorder of Deeds Emergency Act of 2002 (D.C. Act 14-381, June 6, 2002, 49 DCR 5674).
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Concord: creating striking and energy-efficient lighting at Oakham Castle
Oakham Castle in Rutland is benefitting from a striking and energy efficient new lighting scheme thanks to Concord. The new design, which features a number of Concord luminaires, emphasises the castle's aesthetic qualities as well highlighting the intricate architectural features of the historic building
Dating back to the 12th Century, Oakham Castle is one of the finest surviving examples of Norman architecture in England. Upon receiving a £2.2m Heritage Lottery Fund grant, the castle recently underwent a comprehensive restoration turning it into a first-class culture and heritage centre. The work included preserving the castle's key features whilst adding brand new interactive displays and exhibits for guests to enjoy.
As part of the refurbishment, Concord worked with M & E specialists, E P Consulting to develop an effective lighting solution. The installation incorporated exterior and interior lighting solutions, improved facilities and an exhibition fit out to showcase the Castle and its history. The mechanical and electrical services needed to be sympathetically designed to blend in with the structure of the building whilst improving the outside lighting. The team was also tasked with illuminating a unique collection of over 230 ornate horseshoes within the Great Hall, which the Castle is famous for.
"Due to the historic nature of the project, creating the right illumination that is sympathetic with the castle's architecture was essential," says Robert Pitchford, Electrical Director of E P Consulting. "The new lighting scheme has helped us meet the overall goal – an efficient and sustainable solution, and offered us the perfect balance between energy efficient LED technology and a traditional look and feel. The result is a sensitive lighting upgrade to a historic and renowned site giving significant added value to an already popular attraction."
The new design was achieved by using a variety of luminaires to create the desired look in each space. For example, in Court No. 1 track mounted Concord Unity LED direct / indirect luminaires were installed to provide the right light levels and reveal the remarkable features of the room. Concord Beacon Muse LED luminaires have been installed in the Great Hall to provide ambient lighting and emphasise particular aspects. To create a sense of theatre and highlight the distinctive horseshoe collection in the Great Hall, a number of Concord Beacon XL spotlights in medium and wide beam options have been installed.
Meanwhile, Concord Brio IP65 LED feature in the castle's old police cells, Ascent 150 downlights in the WC block and Sylvania's DeltaWing LED and weather resistant Sylproof Superia LED were used in the judges retiring room and plant room respectively. The carefully selected luminaires achieved the required light levels and efficiencies, proving them as the ideal solution for both energy savings and aesthetics.
A suitably dramatic lit environment and energy efficient design was required with visitor safety an important factor of the design concept. Route LED downlight luminaires were installed all over the project to provide non-maintained emergency lighting. The Sylvania SylSafe Twin Flood LED has been used as emergency lighting in the Great Hall and SylSafe emergency exist luminaires have been installed at all exists.
A combination of outdoor luminaires have also been installed to highlight the castle's exterior fascia and create an attractive lighting scene for maximum impact.
For more information visit www.concord-lighting.com.
Optimising museum lighting for flexibility and functionality: Q&A with Concord by Sylvania UK
Concord goes technicolour with new Muse Xicato spotlight
Making impactful lighting accessible to all museums: Q&A with Concord by Sylvania UK
York Minster highlights architectural heritage and makes energy savings with Concord

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Woman saves Amazon boxes for months to pull off hilarious April Fool's Day prank on husband
by: WFLA Staff Reports
Posted: Apr 3, 2019 / 06:08 AM UTC / Updated: Apr 3, 2019 / 11:14 AM UTC
HEMEL HEMPSTEAD, ENGLAND – NOVEMBER 14: Items in "Amazon Prime" branded packaging are seen at the Amazon Fulfillment Centre on November 14, 2018 in Hemel Hempstead, England. The online retailer Amazon will again take part in the now-traditional "Black Friday" sales this year, with reductions available from 16-25 November. (Photo by Leon Neal/Getty Images) (Photo […]
GREEN BAY, Wisc. (WFLA) – A Wisconsin woman is getting a lot of attention online for a hilarious April Fool's Day prank on her husband that took months to plan.
For the past six months, Maureen Pritchard has saved all of the Amazon boxes that have been delivered to her house, as well as boxes from her sister and parents.
On April Fool's Day, she took all of those boxes and placed them in a pile on her front porch, making it look like they had just been delivered. And that's exactly what her husband thought when he got home from work.
Pritchard was inside recording through the front window when her husband Rob pulled into the driveway. Video shows him get out of his car and stare in shock at the boxes before coming inside.
At that point, Pritchard thought her husband had caught on to the prank. But once he was inside the house, she says he kept asking what all of the boxes were.
"I had to explain that it was 6 months of saved boxes, from us, my parents and my sister!" Pritchard wrote in her post. "April Fools!"
Pritchard added, "You have no idea how many people slowed down or stopped in front of our house all day today!"
People on Facebook are absolutely loving her prank. The post has thousands of likes, shares and comments applauding her for her creativity.
NEW YORK (AP) — Baz Luhrmann's Elvis Presley biopic has found its King.
After a competitive casting contest, 27-year-old actor Austin Butler has been cast as Presley. Ansel Elgort, Harry Styles and Miles Teller all reportedly tested for the role ultimately won by Butler, who last year appeared in the Denzel Washington Broadway revival of "The Iceman Cometh."
by Marcia Dunn, AP / Jul 16, 2019
CAPE CANAVERAL, Fla. (AP) — Apollo 11′s astronauts are returning to the exact spot from where they flew to the moon 50 years ago.
NASA has invited Buzz Aldrin and Michael Collins to Kennedy Space Center's Launch Complex 39A on Tuesday. They will mark the precise moment — 9:32 a.m. on July 16, 1969 — that their Saturn V rocket departed on humanity's first moon landing. Mission commander Neil Armstrong — who took the first lunar footsteps — died in 2012.
by Ricardo Alonso-Zaldivar, Associated Press / Jul 15, 2019
WASHINGTON (AP) — Taxpayer-funded family planning clinics must stop referring women for abortions immediately, the Trump administration said Monday, declaring it will begin enforcing a new regulation hailed by religious conservatives and denounced by medical organizations and women's rights groups.
The head of a national umbrella group representing the clinics said the administration is following "an ideological agenda" that could disrupt basic health care for many low-income women.


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'Bharat ki Beti' Uzma Fatima Leaves Blazing Trail of Bravery in Srisailam Power Plant Fire; Saving 4 Lives Cost her Own Life
By Dr Ahmed Mohiuddin Siddiqui
Our Prime Minister Narendra Modi fondly refers to girls as Bharat ki Beti. One such Bharat ki Beti Uzma Fatima, 26, an assistant engineer at the Srisailam Power Plant in the Telangana State left a blazing trail of bravery as she saved 4 of her colleagues from the fire reportedly caused due to short circuit a few days ago. Modi also says: Beti Bachao, Beti Padhao (Save girl child, educate girl child). Young Hyderabadi Uzma's bravery can make us say: Beti Padhao, Beti Bachaati (Educate girl child, she will save you)!
Thousands of girls have been raped and burnt to death. Many others have been burnt to death for dowry. But when girls get a chance, they save the families and the nation. Uzma Fatima was a notch higher in the sense that she saved those 4 colleagues, who were not even her own family. She put humanity first!
Uzma Fatima's father Mohammed Zubair runs a footwear business at Chappal Bazar in Hyderabad. He has three daughters and a son. The elder daughter is married. Uzma Fatima was his second daughter and was unmarried. His youngest daughter is in the eighth standard.
Mohammed Zubair's son Mohammed Minhaj who is a degree college student told that his family is in a state of shock due to the sudden tragedy. According to him, Uzma Fatima was working in Srisailam Power Station as an Assistant Engineer for the past four years. The CCTV footage of the fire accident shows that Uzma had come out of the fire engulfed place. According to the survivors, she saved 4 (four) of her colleagues. She went back to bring out the other assistant engineers trapped there. She could not come of the tunnel along with eight other colleagues. The brave engineers perished in the fire.
It may be recalled that women were finally given combat roles in the Indian Army after a long struggle. Uzma's sacrifice proves that women are second to none in bravery. Women are our best bet to save our country within and on our borders. Rani Laxmi Bai of Jhansi proved her bravery in the battlefield against the British. Every girl in our country is a potential Rani Laxmi Bai. They prove it when they get chances. Our Prime Minister Narendra Modi may certainly be feeling proud about the sacrifice of Bharat ki Beti Uzma Fatima. A fitting tribute to Uzma's memory would be institute a gallantry award her name and also rechristen Srisailam Power Plant as Uzma Fatima Power Plant. It will not only generate electricity but it will also generate bravery for our future generations of girls to emulate.
The Telangana Chief Minister K. Chandrasekhar Rao (KCR) should pay tribute to Telangana's daughter Uzma Fatima by naming a major road in Hyderabad after her. The Malakpet Railway Station near her residence can be named as Uzma Fatima Railway Station. Are Modi ji and KCR Garu listening?
Related Items:Dr Ahmed Mohiuddin Siddiqui, Editor's Pick, Uzma Fatima
Atmanirbhar Bharat and Cow Economy
Challenge of Protecting Human Rights in the Virtual World Beckons Civil Society


text:
Shelley Somerville Sansbury Jr.
b. 23 September 1903, d. 27 June 1982
Father: Shelley Somerville Sansbury d. between 1904 and 1910
Mother: Fannie Isabel Cook b. circa June 1876, d. 26 April 1946
Shelley Somerville Sansbury Jr. was born on 23 September 1903 in Alabama.
The following appeared on 28 July 1907 in The Montgomery Advertiser: Master Shelly Sansbury has returned to the city, from a visit to his cousin, Miss Margaret Ethel Malone, in Atlanta.
Fannie Isabel Cook and May Avery Cook appeared in the US federal census of 15 April 1910 in Montgomery, Alabama, at 225 Jackson Street. Other members of the household included Shelley Somerville Sansbury Jr., Ethel S. Cook.
Fannie Isabel Cook appeared in the US federal census of 1 January 1920 in Montgomery, Alabama, at 225 South Jackson Street. Other members of the household included Shelley Somerville Sansbury Jr.. Also in the household was one male lodger.
The following appeared on 24 October 1920 in The Montgomery Advertiser: Shelly Sansbury, who is a student at the University is spending the week-end with his mother, Mrs. S. C. Sansbury, at her home on Jackson Street.
The following appeared on 25 November 1923 in The Montgomery Advertiser: Shelley S. Sansbury is spending the week-end with his mother, Mrs. S. C. Sansbury on South Jackson street and has as his guest, Norman S. Morgan of the University of Alabama.
He married Christina Radulovich on 16 January 1939 in Hillsboro, Jefferson County, Missouri, by license issued the same day, with N. C. Eaves, JP, officiating.
Shelley Somerville Sansbury Jr. died on 27 June 1982 at age 78.
His wife Christina Radulovich became a widow at his death.
He was interred at Jefferson Barracks National Cemetery, Oakville, St. Louis County, Missouri.
Family: Christina Radulovich b. 12 March 1912, d. 23 November 1993


Augmenix has launched a dedicated UK website to support the growing number of clinicians and patients who are using SpaceOAR® hydrogel to help reduce unnecessary and life-changing side-effects from prostate cancer radiotherapy.
Throughout the UK over 45,000 men are diagnosed with prostate cancer every year.1 This means about 1 in 8 men will get prostate cancer at some point in their lives.2 Many patients are treated successfully with different forms of radiotherapy, but there are known side-effects such as rectal bleeding, rectal pain, impaired sexual function, and faecal and urinary incontinence that result from radiation damage to the organs and tissues surrounding the prostate. SpaceOAR Hydrogel is a soft, implantable gel which is placed with a minimally invasive procedure and is clinically proven to reduce the short and long-term side-effects of radiation exposure.
"The development of a UK centric website provides doctors in the UK and Ireland more clinical information, materials and tools on both the application and benefits of SpaceOAR. Helping them make a difference to men undergoing radiotherapy." said Stephen McGill, Vice President and General Manager of Augmenix International.
1. Prostate Cancer UK. 2018. About Prostate Cancer. [ONLINE] Available at: http://www.prostatecanceruk.org/prostate-information/about-prostate-cancer. [Accessed 15 October 2018].
2. Cancer Research UK. 2018. Prostate Cancer Statistics. [ONLINE] Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/prostate-cancer. [Accessed 15 October 2018].


A small group of FC Cincinnati employees collaborated with MLS and Adidas over a four-month period last summer to produce the primary kit that was unveiled Monday night at Music Hall.
Anyone that knows the story of FC Cincinnati's rapid ascendancy to MLS knows the club wasn't afforded the luxury of time on many fronts in preparing for its jump from the second-division USL to the top league in the U.S. and Canada.
That truth extended to the creation of the club's first-ever MLS jerseys – but the club was still able to pull off a striking look for Year One in MLS with help from MLS Commissioner Don Garber and executives at Adidas.
The normal window for clothing and fashion company Adidas to craft a soccer jersey for an MLS club is about two years, but FC Cincinnati was never going to have that kind of time.
The club was only confirmed as an MLS expansion side for the league in May 2018 – less than 10 months prior to its inaugural season in the league.
But what FC Cincinnati unveiled on the jersey front Monday night during a ticketed event at Music Hall in Over-the-Rhine was widely applauded. That's something or a rarity when kits are released for any club anywhere in the world.
Here's how that was made possible.
The process of at arriving at that kit, as described by those involved, wasn't always a smooth one.
Admittedly, the club's options were limited initially, said team President and General Manager Jeff Berding.
That didn't stop FC Cincinnati from pushing for better when it was initially underwhelmed by what Adidas was presenting to them.
"We challenged them. At first, the original jerseys (Adidas proposed) were beautiful, they were bold. Bold blue. Bold white. But we pushed them to go a little bit further," said Amir Shemony, vice president of marketing and consumer products for FC Cincinnati.
It's not a one-sided process where Adidas necessarily gets the final say. FC Cincinnati stakeholders get to have their say, too.
"After we began the process here in Cincinnati and with the league, Adidas, at a global level, said 'we really love the story of this club and we want to make sure that they wear something that's exciting and reflects well on their incredible journey," Berding said.
Garber weighed in on the league front and backed FC Cincinnati's endeavor for a product that was a little more glamorous.
Adidas responded. The final result was what fans saw Monday night at Music Hall.
"My initial reaction was, well this is a hell of a lot better than what we were looking at previously," Berding said of his initial reaction to the new kits. "I thought it was very attractive."
FC Cincinnati also unveiled on Monday night its secondary jersey, an all-white combination of jerseys, shorts, and socks. The decision to unveil that look so was taken under consideration and approved less than two hours prior to Monday night's primary-jersey event.
Both jerseys are largely monochromatic from top to bottom – a feature of MLS kits that has been a criticism of the Adidas-produced jerseys for the league in recent years.
But given the timeline, and that MLS intervened to help produce a more striking jersey for this season, most fans seemed pleased with the final outcome.
The two FC Cincinnati jerseys unveiled Monday night are for the 2019 MLS season only.
"What you're looking at right here will be the home and away kit for 2019," Shemony said. "We have two new jerseys's coming in 2020, and then we'll be on the regular cycle."
April 23, 2019, 6:29 p.m.


text:
Edin Pepic, früher Edin Sancaktar, (* 13. Juli 1991 in Ratingen) ist ein deutscher Fußballtorhüter, der aktuell vereinslos ist. Er stand bis Dezember 2019 beim Wuppertaler SV unter Vertrag.

Karriere
Edin Pepic hatte in seiner Jugend im Tor bei Borussia Mönchengladbach und beim KFC Uerdingen 05 gespielt, ehe er im Jahr 2006 zu Fortuna Düsseldorf wechselte. In der Saison 2010/11 wurde er dann in den Kader der zweiten Mannschaft aufgenommen und absolvierte sein Debüt in der Regionalliga West am 14. Mai 2011 beim 1:1 im Spiel gegen den 1. FC Kaiserslautern II. Dies blieb sein einziger Einsatz in dieser Spielzeit. In der folgenden Saison wurde Sancaktar häufiger eingesetzt. Er kam auf insgesamt elf Ligaeinsätze, schaffte es allerdings nur zweimal, ohne Gegentor zu spielen.

Zur Saison 2012/13 wechselte er zum Drittligaaufsteiger Borussia Dortmund II, bei dem er einen Einjahresvertrag unterschrieb mit Option auf ein weiteres Jahr. Dort ersetzte er den zum SK Sturm Graz abgewanderten Johannes Focher. Am 3. Februar 2013 absolvierte er beim 3:3 im Spiel gegen den 1. FC Saarbrücken sein Debüt im schwarz-gelben Trikot. Zur Saison 2013/14 wechselte er zum FC 08 Homburg in die Regionalliga Südwest. Nach 29 Ligaeinsätzen für die Homburger wechselte er für die Spielzeit 2014/15 zum Goslarer SC.

Ab der Saison 2015/16 stand er beim Regionalligisten SG Wattenscheid 09 unter Vertrag. Nachdem es bei der SG Wattenscheid schon seit mehreren Jahren finanzielle Probleme gab, verschärfte sich die Situation und der Verein musste letztendlich im August 2019 Insolvenz anmelden. Pepic wechselte daraufhin nach 111 Ligaspielen im Sommer 2019 zum Wuppertaler SV. Der Vertrag wurde jedoch im Dezember 2019 nach zehn Ligaeinsätzen wieder aufgelöst.

Namensänderung
Pepic wurde mit dem Namen Edin Sancaktar geboren, die Familie hieß früher allerdings Pepic. Seine Familie war nach dem Verlassen ihres Heimatlandes Jugoslawien jedoch gezwungen, den Nachnamen zu ändern. Im Januar 2019 konnte Pepic seinen ursprünglichen Familiennamen wieder annehmen.

Weblinks

Einzelnachweise

Fußballtorhüter (Borussia Dortmund)
Fußballtorhüter (FC 08 Homburg)
Fußballtorhüter (Fortuna Düsseldorf)
Fußballtorhüter (Goslarer SC 08)
Fußballtorhüter (SG Wattenscheid 09)
Fußballtorhüter (Wuppertaler SV)
Deutscher
Geboren 1991
Mann

redpajama_set_name: RedPajamaWikipedia


text:
"""Handle Python version/platform incompatibilities."""

import sys

try:
    import threading
except ImportError:
    import dummy_threading as threading

py32 = sys.version_info >= (3, 2)
py3k_warning = getattr(sys, 'py3kwarning', False) or sys.version_info >= (3, 0)
py3k = sys.version_info >= (3, 0)
jython = sys.platform.startswith('java')
pypy = hasattr(sys, 'pypy_version_info')
win32 = sys.platform.startswith('win')
cpython = not pypy and not jython  # TODO: something better for this ?

if py3k_warning:
    set_types = set
elif sys.version_info < (2, 6):
    import sets
    set_types = set, sets.Set
else:
    # 2.6 deprecates sets.Set, but we still need to be able to detect them
    # in user code and as return values from DB-APIs
    ignore = ('ignore', None, DeprecationWarning, None, 0)
    import warnings
    try:
        warnings.filters.insert(0, ignore)
    except Exception:
        import sets
    else:
        import sets
        warnings.filters.remove(ignore)

    set_types = set, sets.Set

if sys.version_info < (2, 6):
    def next(iter):
        return iter.next()
else:
    next = next
if py3k_warning:
    import pickle
else:
    try:
        import cPickle as pickle
    except ImportError:
        import pickle

# a controversial feature, required by MySQLdb currently
def buffer(x):
    return x

# Py2K
buffer = buffer
# end Py2K

try:
    from contextlib import contextmanager
except ImportError:
    def contextmanager(fn):
        return fn

try:
    from functools import update_wrapper
except ImportError:
    def update_wrapper(wrapper, wrapped,
                       assigned=('__doc__', '__module__', '__name__'),
                       updated=('__dict__',)):
        for attr in assigned:
            setattr(wrapper, attr, getattr(wrapped, attr))
        for attr in updated:
            getattr(wrapper, attr).update(getattr(wrapped, attr, ()))
        return wrapper

try:
    from functools import partial
except ImportError:
    def partial(func, *args, **keywords):
        def newfunc(*fargs, **fkeywords):
            newkeywords = keywords.copy()
            newkeywords.update(fkeywords)
            return func(*(args + fargs), **newkeywords)
        return newfunc

if sys.version_info < (2, 6):
    # emits a nasty deprecation warning
    # in newer pythons
    from cgi import parse_qsl
else:
    from urlparse import parse_qsl

# Py3K
#from inspect import getfullargspec as inspect_getfullargspec
# Py2K
from inspect import getargspec as inspect_getfullargspec
# end Py2K

if py3k_warning:
    # they're bringing it back in 3.2.  brilliant !
    def callable(fn):
        return hasattr(fn, '__call__')

    def cmp(a, b):
        return (a > b) - (a < b)

    from functools import reduce
else:
    callable = callable
    cmp = cmp
    reduce = reduce

try:
    from collections import namedtuple
except ImportError:
    def namedtuple(typename, fieldnames):
        def __new__(cls, *values):
            tup = tuple.__new__(cls, values)
            for i, fname in enumerate(fieldnames):
                setattr(tup, fname, tup[i])
            return tup
        tuptype = type(typename, (tuple, ), {'__new__': __new__})
        return tuptype

try:
    from collections import defaultdict
except ImportError:
    class defaultdict(dict):

        def __init__(self, default_factory=None, *a, **kw):
            if (default_factory is not None and
                not hasattr(default_factory, '__call__')):
                raise TypeError('first argument must be callable')
            dict.__init__(self, *a, **kw)
            self.default_factory = default_factory

        def __getitem__(self, key):
            try:
                return dict.__getitem__(self, key)
            except KeyError:
                return self.__missing__(key)

        def __missing__(self, key):
            if self.default_factory is None:
                raise KeyError(key)
            self[key] = value = self.default_factory()
            return value

        def __reduce__(self):
            if self.default_factory is None:
                args = tuple()
            else:
                args = self.default_factory,
            return type(self), args, None, None, self.iteritems()

        def copy(self):
            return self.__copy__()

        def __copy__(self):
            return type(self)(self.default_factory, self)

        def __deepcopy__(self, memo):
            import copy
            return type(self)(self.default_factory,
                              copy.deepcopy(self.items()))

        def __repr__(self):
            return 'defaultdict(%s, %s)' % (self.default_factory,
                                            dict.__repr__(self))

try:
    from weakref import WeakSet
except:
    import weakref

    class WeakSet(object):
        """Implement the small subset of set() which SQLAlchemy needs
        here. """
        def __init__(self, values=None):
            self._storage = weakref.WeakKeyDictionary()
            if values is not None:
                self._storage.update((value, None) for value in values)

        def __iter__(self):
            return iter(self._storage)

        def union(self, other):
            return WeakSet(set(self).union(other))

        def add(self, other):
            self._storage[other] = True

# find or create a dict implementation that supports __missing__
class _probe(dict):
    def __missing__(self, key):
        return 1

try:
    try:
        _probe()['missing']
        py25_dict = dict
    except KeyError:
        class py25_dict(dict):
            def __getitem__(self, key):
                try:
                    return dict.__getitem__(self, key)
                except KeyError:
                    try:
                        missing = self.__missing__
                    except AttributeError:
                        raise KeyError(key)
                    else:
                        return missing(key)
finally:
    del _probe

try:
    import hashlib
    _md5 = hashlib.md5
except ImportError:
    import md5
    _md5 = md5.new

def md5_hex(x):
    # Py3K
    #x = x.encode('utf-8')
    m = _md5()
    m.update(x)
    return m.hexdigest()

import time
if win32 or jython:
    time_func = time.clock
else:
    time_func = time.time

if sys.version_info >= (2, 5):
    any = any
else:
    def any(iterator):
        for item in iterator:
            if bool(item):
                return True
        else:
            return False

if sys.version_info >= (2, 5):
    def decode_slice(slc):
        """decode a slice object as sent to __getitem__.

        takes into account the 2.5 __index__() method, basically.

        """
        ret = []
        for x in slc.start, slc.stop, slc.step:
            if hasattr(x, '__index__'):
                x = x.__index__()
            ret.append(x)
        return tuple(ret)
else:
    def decode_slice(slc):
        return (slc.start, slc.stop, slc.step)

if sys.version_info >= (2, 6):
    from operator import attrgetter as dottedgetter
else:
    def dottedgetter(attr):
        def g(obj):
            for name in attr.split("."):
                obj = getattr(obj, name)
            return obj
        return g

import decimal

redpajama_set_name: RedPajamaGithub


What is FTP? File Transfer Protocol - used for uploading files to web hosting.
FTP: How to upload files Use an FTP client to upload your files to your hosting.
Find your FTP login (cPanel) Find your FTP information for cPanel hosting.
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text:
Alpine Immune Sciences Announces Presentation of Preclinical Data Showing Potency of Its First-Generation Dual ICOS and CD28 Antagonist vIgDs in an Animal Model
By David Miller June 14, 2017 Home Page, Press Release
— Company Plans to File IND in 2018 for First in Class Molecule —
SEATTLE, Wash., June 14, 2017 – Alpine Immune Sciences, Inc. (Alpine), a biotechnology company developing a next-generation immune modulation platform, today announced results from a preclinical study evaluating first-generation variant Ig domains (vIgDs™) from the company's lead program, ALPN-101. These vIgDs consisted of an ICOS ligand-based inhibitory domain engineered to acquire CD28 modulatory properties, creating a potential first-in-class dual ICOS/CD28 pathway inhibitor. Results presented demonstrate meaningful activity in an aggressive animal model of graft vs. host disease (GvHD), suggesting that the ALPN-101 program and other Alpine vIgDs could potentially have clinical therapeutic utility in multiple inflammatory diseases. The data will be presented today in a poster session at FOCiS 2017, the annual meeting of the Federation of Clinical Immunology Societies, in Chicago.
"This study demonstrates meaningful activity in an animal model of one of Alpine's first‑generation vIgDs, part of the ALPN-101 development program. This is noteworthy because there are currently no FDA-approved therapies for the treatment of GvHD, and the severity of the disease model suggests that ALPN-101 vIgDs may be useful for other inflammatory conditions as well," said Stanford Peng, M.D., Ph.D., executive vice president of Research and Development and chief medical officer of Alpine.
Additional preclinical studies are currently underway with Alpine's second- and third-generation ALPN-101 vIgDs, with results expected to be presented in an upcoming scientific forum.
GvHD currently has no FDA-approved treatment options, and has a major impact on survival following transplantation. Transplant-related mortality is as high as 92 percent in grade IV acute GvHD. Approximately 30 to 50 percent (2,500 – 4,200 per year in the U.S.) of bone marrow transplant patients will develop clinically significant GvHD.
"These preclinical data suggest directed evolution of immuno-modulatory domains via our vIgD platform can provide the basis for novel therapeutics for the treatment of GvHD and other serious inflammatory conditions," said Mitchell H. Gold, M.D., executive chairman and chief executive officer of Alpine. "With our upcoming merger with Nivalis Therapeutics, we expect to have significant resources to accelerate the development of our platform into other promising areas for both inflammation and oncology applications."
Preclinical Study Design and Results
The immunoglobulin superfamily (IgSF) is a large, diverse family of proteins expressed on immune cells that play a critical role in regulating the immune system. These proteins have been extensively studied in cancers and autoimmune diseases. Most therapeutic strategies targeting this family of proteins have employed monoclonal antibodies binding to a single receptor on a cell. In contrast, Alpine's vIgD platform seeks to engineer human IgSF extracellular domains, potentially tailoring their affinity to multiple but specific target ligands.
In the preclinical study presented at FOCiS 2017, Fc fusion proteins incorporating these evolved immunomodulatory IgSF domains were tested in vitro and in vivo. Belatacept, an FDA-approved immunosuppressive T-cell co-stimulation blocker, was used for comparison.
Results showed that in an animal model Alpine's novel first-generation ICOS/CD28 dual antagonist vIgDs were more potent than belatacept in attenuating T cell activation in vitro as assessed by proliferation and cytokine production. Alpine's first-generation ICOS/CD28 vIgD molecule also significantly reduced markers of disease activity in an animal model of GvHD as assessed by a standard disease activity score (comprised of overall health and activity, skin and hair changes, and body weight loss).
Alpine's Planned Merger with Nivalis Therapeutics
In April 2017, Alpine and Nivalis Therapeutics, Inc. (NASDAQ: NVLS) announced that they had entered into a definitive merger agreement under which Alpine will merge with and into a wholly‑owned subsidiary of Nivalis in an all-stock transaction with the surviving company named 'Alpine Immune Sciences, Inc.' and trading on the NASDAQ under the ticker symbol 'ALPN'. The merger will result in a combined company with a novel protein-based discovery platform focused on inflammation and immuno-oncology. The merger is expected to close in the third quarter of 2017, subject to the approval of the stockholders of each company and the satisfaction or waiver of other customary conditions.
About Alpine Immune Sciences, Inc.
Alpine Immune Sciences, Inc. was founded in 2015 and is focused on developing novel protein‐based immunotherapies using its proprietary variant immunoglobulin domain (vIgD) platform technology. The vIgD platform is designed to create novel therapeutics that modulate multiple therapeutic targets, including many present in the immune synapse. Alpine's vIgDs are developed using a unique process known as directed evolution, which can produce proteins capable of either enhancing or diminishing an immune response and thereby may apply therapeutically to both oncology and inflammatory diseases. Alpine has also developed its transmembrane immunomodulatory protein (TIP™) technology, based on the vIgD platform, to enhance engineered cellular therapies. In October 2015, Alpine signed a worldwide research and license agreement with Kite Pharma, Inc. (NASDAQ: KITE) for up to $535 million in upfront and potential milestone payments and, in addition, royalties on resulting sales. The agreement allows Kite access to certain targets developed using Alpine's TIP platform. For more information visit www.alpineimmunesciences.com/.
About Nivalis Therapeutics, Inc.
Nivalis Therapeutics, Inc. (http://www.nivalis.com) is a pharmaceutical company that has historically been focused on the discovery and development of product candidates for patients with cystic fibrosis, or CF. Nivalis' development candidates selectively target an enzyme known as S-nitrosoglutathione reductase (GSNOR). GSNOR regulates levels of an endogenous protein known as S-nitrosoglutathione, or GSNO. Depleted levels of GSNO have been associated with CF, asthma, inflammatory bowel diseases and certain cardiovascular diseases. Following recent disappointing results of a Phase 2 clinical trial of its lead product candidate, cavosonstat, in CF, Nivalis determined to not pursue the development of this compound in CF and to wind down its research and development activities while devoting its efforts to investigating and evaluating strategic alternatives.
This communication contains forward-looking statements (including within the meaning of Section 21E of the United States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended) concerning Nivalis, Alpine (including Alpine's platform technology, potential therapies, clinical and regulatory objectives and milestone and royalty payment potential), the proposed merger transaction between Nivalis and Alpine and other matters. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the managements of Nivalis and Alpine, as well as assumptions made by, and information currently available to, management of Nivalis and Alpine. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as "may," "will," "should," "would," "expect," "plan," "believe," "intend," "look forward," and other similar expressions among others. Statements that are not historical facts are forward-looking statements. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation, that the conditions to the closing of the merger transaction are not satisfied, that available cash is lower than estimated, that Alpine's discovery-stage and preclinical program do not advance into the clinic or result in approved products on a timely or cost effective basis or at all. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in Nivalis' registration statement on Form S-4, including the proxy statement/prospectus/information statement therein, Nivalis' most recent Annual Report on Form 10-K, and Nivalis' recent Quarterly Report on Form 10-Q and Current Reports on Form 8-K filed with the Securities and Exchange Commission (the "SEC"). Neither Nivalis nor Alpine can give any assurance that the conditions to the merger transaction will be satisfied. Except as required by applicable law, neither Nivalis nor Alpine undertakes any obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.
No Offer or Solicitation
This communication is not intended to and does not constitute an offer to sell or the solicitation of an offer to subscribe for or buy or an invitation to purchase or subscribe for any securities or the solicitation of any vote in any jurisdiction pursuant to the proposed transaction or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the United States Securities Act of 1933, as amended. Subject to certain exceptions to be approved by the relevant regulators or certain facts to be ascertained, the public offer will not be made directly or indirectly, in or into any jurisdiction where to do so would constitute a violation of the laws of such jurisdiction, or by use of the mails or by any means or instrumentality (including without limitation, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or any facility of a national securities exchange, of any such jurisdiction.
Additional Information about the Merger and Where to Find It
In connection with the proposed merger, Nivalis has filed a registration statement on Form S-4 with the SEC, including a proxy statement/prospectus/information statement.. The proxy statement/prospectus/information statement and any other relevant documents filed by Nivalis with the SEC may be obtained free of charge through the website maintained by the SEC at www.sec.gov. In addition, investors and stockholders may obtain free copies of the documents filed by Nivalis with the SEC (when they become available) by directing a written request to: Nivalis Therapeutics, Inc., PO Box 18387, Boulder, Colorado 80308, Attention: Investor Relations. Investors and stockholders are urged to read the proxy statement/prospectus/information statement and the other relevant materials before making any voting or investment decision with respect to the proposed merger.
Participants in the Solicitation
Nivalis and Alpine, and each of their respective directors and executive officers and certain of their other members of management and employees, may be deemed to be participants in the solicitation of proxies in connection with the proposed transaction. Information about Nivalis' directors and executive officers is included in Nivalis' Annual Report on Form 10-K for the year ended December 31, 2016, filed with the SEC on February 13, 2017, and the proxy statement for Nivalis' 2017 annual meeting of stockholders, filed with the SEC on April 6, 2017. Additional information regarding these persons and their interests in the transaction is included in the proxy statement/prospectus/information statement referred to above.
Alpine Immune Sciences, Inc.
News and Press Archives
Twitter | @AlpineImmuneSci


text:
You are currently browsing the monthly archive for September 2012.
A reason to visit Florida
Sunday, September 30, 2012 in Florida
I've got a very good friend in Florida who is always telling me I should come visit him. "You'd love it here," he says. "Particularly in winter. It's sunny, warm, beautiful."
Yes, I tell him, but I live in California where it is also sunny, warm, and beautiful.
"This is different," he says. "You should give it a try."
I told him that he could write a guest blogetorial about Florida and I'd let my readers decide whether I should go to Florida or not. So read what he has to say and let me know if you think I should visit:
"As you well know, my friend, traveling is perhaps the best way to unwind and relieve oneself of stress. It can also be a good source of inspiration for people who need to have some positivity in their life (and after reading your blogs about the Apache rodeo in Arizona, I think a little sunshine and positivity would be good for you). Go to Florida with your family and experience a great vacation filled with sunshine and adventures amongst the state's many varied attractions.
"Family holidays to sunny Florida are getting more expensive. So it is important to look at sites such as Thomson to browse their range of sunshine holidays and make the most of your visit. And you can save some money by economizing in small ways every day. For instance, before you travel, make sure that you have taken all the necessary things you need on your holidays, like sun glasses, tanning lotion, batteries for games, etc. so that you don't have to cut into your travel budget by buying things you have forgotten to bring.
"That said, clothes and some other travel items are much cheaper in Florida, so you may want to travel light and buy your holiday clothes there, if you have a set budget. Make a packed lunch and have a picnic, rather than buying lunch at over-priced cafés and restaurants.
"The heat will make you thirsty, so buy your canned and bottled drinks in a supermarket. It will be much cheaper than visiting cafés. If you are planning to see several top attractions it will be cheaper to buy a Go Miami card.
"You will get in 37 Admission attractions with this, and you can get it for 1, 2, 3, 5, or 7 days. Used wisely, this will save up to 55% of gate prices, money saved which you can then spend on other things. Here are some of the top attractions you might consider visiting"
Jungle Island in Florida
A liger looks kind of like a giant lion with stripes.
"I love this place and think It is well worth a visit to see all the wonderful rare animals there, like the liger, who is the world's largest cat, the orangutan twins, capuchin monkeys, various parrot species and Aldabra tortoises, lemurs and the rare six-foot tall tame Cassowary called Mama Cass. It is set in lush and beautiful surroundings and there are several shows and presentations to help you find out more about the animals. Included in your Jungle Island ticket is a complimentary shuttle service to Downtown Miami and South Beach.
Everglades Alligator Farm & Airboat Ride
"Florida is synonymous with alligators, so seeing them on your trip is a must. The Everglades alligator farm has 2000 of the creatures. Step into an airboat and go on a guided tour through the river of grass to make friends with them.
Millionaire's Row Cruise on the Island Queen
"Take a relaxing cruise along the Biscayne Bay on the Island Queen. You will see Miami's coastal skyline, 'Millionaire's Row' – the homes of the rich and famous and Fisher Island. You could also go on the Jungle Queen Riverboat and stop at the Jungle Queen Indian Village, and learn a bit about the history of the Seminole tribe.
"What else? The Miami Seaquarium is worth a visit just to see the dolphins, seals and sea-lions. And the Kennedy Space Center, where you can tour NASA's launch and landing facilities, try one of the interactive space simulators. and maybe even meet a real member of NASA's Astronaut Corps.
"I could go on and on but I think you get the idea—there's a lot to do here. So what do you think? Want to visit?"
Tags: Florida vacation, things to do in Florida
Ol' Paint dies up in Anza-Borrego's Coyote Canyon
Saturday, September 29, 2012 in Anza-Borrego, California | 1 comment
Attempting to cross the creek in Anza-Borrego's Coyote Canyon.
Change of plans. Instead of going to the old calcite mine, "Borrego" Paul decides he's going to take us to Coyote Canyon which, he says, isn't near an earthquake fault zone, "it's directly on it." That's why there's a year-round creek that flows here in the desert. The creekbed follows the fractured rock of the San Jacinto fault zone which separates the mountain ranges that run through Anza-Borrego, the San Ysidro on the southwest and the Santa Rosa on the northeast.
"Borrego" Paul's intention is to show us this unusual riparian wetlands which support dense stands of willows as well as cottonwood trees, acacia, and California fan palms.
We've made two crossings through the creek without any problem, but it's when Paul decides to attempt a third one, in water a little deeper and wider than the others, that his Jeep, Ol' Paint, up and dies.
"Come on, baby," he says, trying to sweet talk her into moving. But Paint will have none of it. Standing up to her headlights in murky green water, she wheezes and backfires but refuses to move. Meanwhile, water is quickly seeping into the car from underneath the doors. We are in the middle of nowhere, approximately 6 miles away from the nearest paved road, on a blistering hot day with a dead vehicle.
"Well, boys," says "Borrego" Paul, jumping out of Ol' Paint and into the bug-infested green water. "Looks like you're going to get more of a desert adventure than you bargained for."
While Dale and I scratch our heads and wonder what to do, "Borrego" Paul grabs his cell phone and heads back down the road a mile or so to a high point where he thinks he might be able to get reception. An hour or so later, Paul's wife, Sandy, has come to our rescue, pulling us out of the creek. After letting Paint dry out for half an hour or so, Paul gives her another go and she starts right up. In a two-car convoy, we head out of the desert as the afternoon draws long. When we come to the creek crossings, "Borrego" Paul pats the dashboard and talks the Jeep through the stream."
"Easy, Paint…Easy now…Easy. Good girl"
Ol' Paint does just fine.
As we pull into Borrego Springs, the sun just setting, "Borrego" Paul idles up in front of a local bar and offers to buy us a beer. "Or," he says with a mischievous grin on his face, "we could head out into the desert with the lights off and see what we can find."
Ten minutes later we are flying across a dry sand wash heading for the open desert with no particular destination in mind. Another adventure about to begin.
Tags: Anza-Borrego, Anza-Borrego Jeep tour, Coyote Canyon
A quiet morning at Casa del Zorro in Anza-Borrego
Friday, September 28, 2012 in Anza-Borrego, California
The old pool at La Casa del Zorro in Anza-Borrego.
On that trip to Anza-Borrego with "Cholla" Dale, I stayed in Room 162 in the Wisteria wing of La Casa del Zorro. I know because I still have the hand-written letter from the general manager welcoming me and inviting me to join him for a cocktail at the Fox Den lounge "at your convenience."
That night I slept without the air-conditioning. Instead, I threw open the French doors of my bedroom but at daybreak the light and heat streamed in through my open doors even though it was not yet seven in the morning. So I got up and put on my bathing suit and quietly slipped into the pool in the courtyard, floating in the shadows cast by a honey mesquite tree.
There are few things more pleasant than swimming alone in a pool shortly after daybreak.
An hour or so later, "Cholla" Dale emerged from his casita, squinting at the bright desert morning. He came over and sat next to the edge of the pool in his bathrobe.
"How long have you been up?" he asked.
I told him. He nodded without saying anything. After awhile he went back to his casitas and came out in his swimsuit. He paddled around at one end of the pool while I made little ripples in the water at the other.
"Very civilized," said "Cholla" Dale. "Very, very civilized."
Around nine we ordered a pot of coffee and breakfast from room service. We ate next to the pool, not talking but just looking around at the papery bougainvillea and the spiky succulents and cacti in the garden as if we'd never seen plants like this in our lives.
"What's the game plan?" "Cholla" Dale said when he'd finished his second cup of coffee.
"I think 'Borrego' Paul is picking us up around ten and we're going to go explore an old calcite mine."
"Cholla" Dale nodded his head. "An old calcite mine," he repeated.
I nodded.
"What, exactly, is calcite?" he asked.
I told him I had no idea.
"Doesn't matter."
"Just going for a Jeep ride is good."
"A Jeep ride in the desert." He was quiet for a moment and then, looking around at our surroundings, said, " I love the desert."
"I thought you told me you weren't really a desert person."
"That was before," said "Cholla" Dale. "This is now."
Tags: Anza-Borrego, Borrego Springs, La Casa del Zorro
"Cholla" Dale and "Borrego" Paul at the Borrego Badlands
Thursday, September 27, 2012 in Anza-Borrego, California | 1 comment
"Borrego" Paul looking out over the Borrego Badlands at sunset.
Dale Conour, a travel editor at Sunset who is also an amateur astronomer, wanted to tag along on my trip to Anza-Borrego in hopes of catching a glimpse of the Perseid meteor shower. This was during my last trip there about ten years ago.
As Dale and I drove to Anza-Borrego he warned me that he wasn't really a desert person. In fact, he said, the last time he'd spent any time in the desert, he went on a guided hike where he bumped into the painful barbs of a cholla cactus not once but twice.
"They seem to be attracted to me," he said.
From that point on, I called him "Cholla" Dale. It seemed to suit him.
Nicknames are big in the desert. There was "Death Valley Scotty," an eccentric from Kentucky who convinced a Chicago millionaire to invest in a gold mine in Death Valley and then build this odd two-story Spanish Colonial home in the desert called Scotty's Castle. There was the prospector and horse thief, "Peg Leg" Smith, who traveled to the Borrego Badlands in the 1850s and supposedly found a gold mine in the Santa Rosa Mountains that people are still looking for. And then there's "Borrego" Paul.
"Borrego" Paul used to lead Jeep tours out in Anza-Borrego. On this particular drip, "Cholla" Dale and I were sitting out front of Casa del Zorro about an hour before sunset waiting for "Borrego" Paul to come pick us up and take us out into the desert to look at stars.
"Borrego" Paul was telling us all about Peg Leg Smith when, without notice, he whipped the Jeep off the highway and down a dry sand wash, plumes of dust rising behind us. He was taking us to Fonts Point. After a few miles we parked at an informal parking spot in the desert and "Borrego" Paul led us across a smooth bluff where, suddenly, the most astonishing view appeared before us. Hundreds of feet below were the convoluted mud hills and sinuous, corrugated ridges of the Borrego Badlands, a landscape shaped from thousands of years of erosive wind and water.
There was no wind on this warm twilight eve, no distant sound of jets or cars, no barking dogs or singing birds. In fact, I'd say it was the most silent spot I'd ever been to.
"You go down there, you'll find prehistoric shark teeth," Paul said. "This all used to be part of the Sea of Cortez. A very long time ago."
Not until the sun had completely set and the Badlands had all but disappeared into their dark shadows did we finally leave. We fishtailed in the Jeep through the soft sand, lights off, as the night cloaked the desert in blackness until Paul suddenly stopped the Jeep in the middle of nowhere. We unloaded folding chairs, opened a bottle of Veuve Clicquot, and with heads tilted back towards the moonless sky, watched awe-struck as meteors flashed and burned above us with such frequency that after a few minutes we stopped even bothering to count them.
"It's like being at the beginning of time," said "Cholla" Dale, happy as could be.
And it was.
Tags: Anza-Borrego, Borrego Badlands, desert jeep tour, Fonts Point
The death of La Casa del Zorro
Wednesday, September 26, 2012 in Anza-Borrego | 13 comments
A postcard, from 1999, of La Casa del Zorro in Anza-Borrego.
From Tucson I drove west, out of the Sonoran Desert and into the Mojave, the smallest desert in the West, and then south to Anza-Borrego, two hours east of San Diego. There was a time, back in the mid- to late-90s, when Anza-Borrego was considered the new secret desert hideaway in California, during a time when Palm Springs was on the outs and nobody went to Death Valley anymore. In a period of about five years—from 1996 to, say, 2001—I was asked by a number of publications, including National Geographic, Los Angeles Magazine, Sunset, Westways, and the Los Angeles Times magazine, to write about this hot (literally) new getaway. And I'd always stay at La Casa del Zorro, partially because there weren't a lot of options but also because I liked the desert glamour of the place.
It was relatively small (44 poolside rooms and 19 one-to-four bedroom casitas) and quiet and had a certain desert elegance to it (which was reflected in four-star, four-diamond rankings). Some very memorable things happened to me while staying at La Casa del Zorro. Some I wrote about; some I did not.
I had not stayed at the resort for ten years so I when I got in to Borrego Springs late yesterday afternoon, I was anxious to go out and see how the ol' gal was doing.
Not very well, I'm afraid.
The entrance was blocked off by a chain-link fence with a No Trespassing sign hanging on it. Seems in the intervening decade La Casa had died.
Back at my hotel, the classic Palms at Indian Head, I had a beer at their restaurant, the Krazy Coyote, and asked the bartender what the hell had happened to La Casa del Zorro. Seems I'd missed a lot since I was last there. About four or five years ago, the Copley family, which had bought the resort (then unimaginably called The Desert Lodge) in 1960, sold the troubled property for something like $2.5 million to a developer who owned a golf course with upscale homes on it just down the road. He renamed it Borrego Springs Ranch.
The guy put another $7 million into the property in a major renovation effort. Bad timing. The economy tanked and the resort was closed in January 2010. And it's been closed ever since. Supposedly the whole 38-acre resort, including the freshly renovated rooms, many of which were never opened after the renovation, is on the market for $3.3 million, which seems like a bargain to me. If I was a Gordon Gecko-type I'd buy it in a heartbeat. Not to restore it as a resort but just to use as an incredibly secluded desert hideaway. A place where I could float alone in the resort pool late at night, watching falling stars streak across the inky sky.


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1a: We completed study of TRPV4 gene designed to identify if 1500 ICD9 codes-derived clinical outcomes (Denny JC et al. Nat Biotechnol. 2013 Dec;31(12):1102-10) were associated with gene variation using Vanderbilt's BioVU biobank. We observed associations with cluster of lung edema-linked, heart failure and cardiac outcomes as well as renal diseases and dysmenorrhea-linked outcomes that have not been previously reported. If replicated, these associations would provide a link between human disease and the TRPV4 gene, an important drug target. We seek an opportunity to evaluate these associations in the UK Biobank resource.
1b: This proposed research is focused on generating results that would provide human genetic target validation for a drug target for heart failure and related conditions in early stage development which fulfills the UK biobank stated purpose which is to improve the prevention, diagnosis and treatment of illnesses.
1c: The research will entail defining outcomes and performing statistical analysis of existing genetic data The outcomes will need to be defined using linked healthcare data and to be consistent with outcomes used for the analysis within the BioVU data and described in the 2013 Nature Biotechnology paper. Statistical genetic analysis will utilize logistic regression adjusting for necessary covariates. Results would be published in a peer reviewed journal.
1d: The study will utilize all participants with adequate phenotype and genetic data – 500,000.


text:
Hadiya is Free But the Soap Opera Shamed Us All
What does Hadiya's victory in the SC mean for Indian women?(Photo: Liju Joseph/The Quint)
Nidhi Mahajan Updated: 10.03.18
Opinion 4 min read
A historic order. On Women's Day, that too!
A great move towards women's freedom of choice. A fantastic step in favour of inter-religious marriages. A slap in the face of 'Love Jihad'. More power to Hadiya!
Hadiya has been in and out of the courts, seeking justice, for two years now.
Better late than never, right? Wrong.
Also Read: Victory for Hadiya: SC Reinstates Marriage, Sets Aside HC Order
The Soap Opera and the Minefield
Before we begin to applaud the Supreme Court for upholding Hadiya's right to live with her husband — a welcome move, no doubt — let's pause and reflect.
Hadiya, a 25-year-old woman studying medical sciences converted to Islam out of her own volition and later married a Muslim man on (guess what!) her own will.
On 8 March 2018 — which happens to be International Women's Day — the SC bench, headed by CJI Dipak Misra, reiterated exactly the above stated facts (as reported by Bar and Bench). "Hadiya alias Akhila Asokan is at liberty to pursue her future endeavours according to law," the SC said.
For two long years, however, there was an attempt to shape these facts about Hadiya's life (her life!) into a soap-opera where the woman was surrounded by a minefield of sanskaar and maryada, Islamophobia and mysogyny.
A Study of Our Greatest Fears
Everyone wanted a slice of this meaty story. Aur aisa kyun na ho [and why won't it be], Hadiya's story brings out some of our (I would say 'society's', but we are nothing if not constituent parts of it) greatest fears.
Conversion. How dare you choose a faith other than the one you were born into? No sensible person would do that unless they were brainwashed.
You might be accepted in this society if you were to become an atheist but to convert to Islam! This brings us to the second fear.
Islam. As recently as last week Hadiya's father claimed before the apex court that his efforts prevented his daughter from being transported to "extremist-controlled territories" of Syria to be used as a "sex slave or a human bomb".
The instant internalised association of Islam or being Muslim with terror groups like the ISIS is a cause and product of a fear of Islam.
For a woman to love a man of her choice. This is what happens when you send your daughters and sisters to study in a different city. They fall in love with men — who are not chosen by you to be their lawful protectors — and as Hadiya's father claims, surrender themselves to "complete strangers".
The fear is doubled if the man is involved in politics, quadrupled if it's Left politics, and the fear appears in full force if the man is also a Muslim (refer to point 2).
For a woman to have a mind of her own. A rare creature, an alien, completely against the natural order of things. Hadiya is not an intelligent woman but a "vulnerable adult". So, for two years her consent was undermined and her voice fell on deaf ears.
But wait... the system is nothing if not progressive, so Hadiya (or shall we say Akhila?) was sent back to complete her medical degree. Who cares that all she wanted was to be with her husband?
Hadiya Jahan, known as Akhila Ashokan before she converted to Islam, married Shafin Jahan in December 2015.
( Photo: Image altered by The Quint)
Freedom at Last?
These are not just fears, they are also our greatest challenges as a society.
On this Women's day, Hadiya walks free — a conditional freedom (of course!) since the apex court has directed the NIA to continue their probe regarding the alleged 'Love Jihad'. This freedom, however, should have been her right all along.
Two years might appear to some as quick when it comes to the Indian judicial system where cases eat dust for years and years, but two years is a long time in the life of a person.
So, forgive me if instead of applause, I can only offer a sarcastic clap.
Hadiya's case is an important step in the long and ongoing battle for women's rights in India. Let the conversation not cease at Hadiya but extend to unreported cases of injustice as well as to our social attitudes.
(Hey there, lady! What makes you laugh? Do you laugh at sexism, patriarchy, and misogyny? Do 'sanskaari' stereotypes crack you up? This Women's Day, join The Quint's Ab Laugh Naari campaign. Pick up that beer, say cheers, and send us photographs or videos of you laughing out loud at buriladki@thequint.com.)
Follow our Opinion section for more stories.


Entering a recovery center like Olalla Recovery Centers to get treatment for your drug or alcohol addiction is one of the best ways to begin to better your life. However, while you detox from these addictions, you may experience many unpleasant symptoms and side-effects. Preparing yourself for these things will help you better deal with them.
One symptom many people experience in a recovery center is night sweats. When you sleep, you may become extremely hot and uncomfortable, sweating to the point that your pajamas and sheets can become soaked. Here are a few tips to help minimize the sweats and your discomfort during them.
Caffeine stimulates the brain and the nervous system. This can can cause many symptoms, including anxiety, aggression, increased heart rate, irritability, restlessness and even sweating. While avoiding caffeine during the detox process will not stop you from having night sweats, the last thing you want to do is possibly make the night sweats worse or more frequent. It is advised you limit or avoid items with caffeine in them, such as chocolate, cola and coffee.
It is important to note that if you consume a large amount of caffeine normally, you can experience withdrawal symptoms when you begin to avoid it. So, it is recommended you slowly begin to cut back on caffeine, rather than go cold turkey, to minimize these symptoms, and to ensure you aren't making alcohol or drug withdrawal more challenging by experiencing caffeine withdrawal at the same time.
When you exercise, your body temperature rises as you heart rate increases. And while it may feel like you cool after you complete your workout, your metabolic rate still remains high. For extremely vigorous activities, that rate can remain high for up to 24 hours following a workout, though it is much less for less vigorous exercises.
When your metabolic rate is higher, you may feel warmed and be more prone to night sweats. As such, if you are in a recovery center for drug or alcohol treatment, you will want to avoid vigorous exercise which can raise your metabolic rate for prolonged periods of time, and any type of exercise right before bedtime. Jogging in the morning or yoga or a walk in the afternoon will allow you to remain active without causing your body temperature to rise, which could increase the intensity of the night sweats you may experience during withdrawal.
Paying close attention to what you eat can help to regulate your body temperature, which can help decrease the intensity of the night sweats you experience.
Unfortunately, when you are withdrawing from alcohol and drugs, there is a good chance you will experience night sweats. This is a normal reaction to getting these toxins out of your body. While there is nothing you can do to stop them, there are things you can do to make yourself more comfortable, such as wearing thin pajamas and using breathable cotton sheets. Limiting caffeine, evening exercise, and foods that raise your body's temperature can also help to keep your body a bit cooler, which can decrease the intensity of the night sweats and keep you just a little more comfortable.


HEALEY-Claire I. (nee King) of Rockville Centre, New York, on December 15, 1998. Beloved wife of Major Gen. Joseph A. Healey, USA (Retired). Devoted mother of Andrew, Monica, Maureen (Cashin), T.J. and Meaghan and son-inlaw Terry Cashin and daughter-inlaw, Marie (Wagner). Loving grandmother of Grace, Liam and Michael. Beloved sister of Jean Cantwell and Dorothy Walker and many nieces & nephews. Faithful member of the Nassau Womens Club and St. Agnes Cathedral Rosary Altar Society. Family will receive friends at Macken Mortuary, 52 Clinton Ave, Rockville Centre, NY, Thursday and Friday, 2-4 and 7-9PM. Mass of the Resurrection St. Agnes Cathedral, at 9 A.M. on Saturday. Interment Holy Rood Cemetery, Westbury.


The Shluchim at Yeshivas Lubavitch Cincinnati work around the clock looking for creative ways to motivate and challenge the Bochurim in their Hiskashrus, learning, and Chassidishe Hanhagos.
Approaching Yud Shvat, and the organized Yeshiva visit to the Rebbe that comes with it, the Shluchim launched an intense Mivtzah bringing the Yud Shvat atmosphere to every Bochur in Yeshiva. The Mivtzah, lasting for two weeks, included learning and memorizing hundreds of pages of Sichos, Ma'amorim, letters, and stories of the Rebbe addressing the essence of a Rebbe, Hiskashrus, and our role as Chassidim and Temimim.
These were compiled in a beautiful booklet, produced exclusively for the Mivtzah. There were also several missions required. The reward: a 3-day Shabbaton to Chicago, plus a Chinese auction on dozens of high-priced items and seforim sets using tickets purchased with points earned in the Mivtzah!
The success surpassed expectations by far, and the Shluchim didn't let down either.
The long awaited and well-earned Shabbaton began with an early Friday morning trip to Chicago, stopping at an Indianapolis Chabad House directed by Shliach Rabbi Avrohom Grossbaum, for Seder Chassidus, Shachris, and a lavish breakfast.
Arriving in Chicago, after yet another stop – an exciting outing, the Bochurim dispersed to their assigned hosts, who showed outstanding and generous hospitality. They then gathered for a lively Kabolas Shabbos at the Chicago Moshiach Center, followed by delicious and heimishe Shabbos meals at their hosts, and ending off with an inspiring Farbrengen led by Rabbi Eliezer Turen, who in his unique way took the Bochurim on a ride through the Sichos and Horaos of the years of Nun Alef-Nun Beis and tried to bring them down and apply them to a Bochur's day to day life. Shabbos day consisted of learning, Davening, and a special Farbrengen all through the afternoon.
If anyone thought the schedule would be loosening up, they were shortly proven wrong. Motzoei Shabbos brought with it a wave of enjoyable events including a milchig Melavah Malkah, a Chassidishe Ma'ase from Rabbi Levi Bukiet, and the grand Chinese auction for the Bochurim excelling in the Mivtza.
Before returning to Yeshiva, the Bochurim enjoyed another exciting trip, and most importantly – a historical opportunity to visit the house where the Frierdiker Rebbe stayed during his 5690 (1930) visit to Chicago. The Bochurim arrived back in Cincinnati with (lots of Seforim and other items won in the auction, and) a new inspiration and commitment to continue their Yud Shvat Hachlotos in the Frierdiker Rebbe's and the Rebbe Melech Hamoshiach's spirit.
The Talmidim HaShluchim gratefully thank all those who made this Shabbaton the success it was: Rosh Yeshivah Rabbi G. Avtzon; Menahel Ruchnei Rabbi M. Benarousse and the rest of the Hanhalas Hayeshivah; Rabbi Eliezer Turen and the entire congregation of the Chicago Moshiach Center. Rabbi Ahron Wolf of the Chicago Mivtza Campaign; the Bunin, Klienman, Turen, Peysin, Popper and Zimmerman families.
Other yeshivas should learn from cincinnati yeshiva. The personal attention, care, varmkeit is just unbelievable!!
I personally heard from the bocherm how amazing the mivtza was, both in regards to the material they learnt and obviously the shabbaton!!!
What is the picture of the floor meant to be?
Wow it's so nice that the yeshiva has such good Mivtzas, the Bochurim enjoy them so much.
Is it not appropriate to have a picture of the Rebbe in the shul (even though it is not on the mizrach wall)?
I do not mean to be disrespectful.