Našli jsme další záznamy k osobě Charles Deloy Leavitt.
Charles Deloy Leavitt je pohřben(a) na hřbitově Leavitt Cemetery v místě zobrazeném na níže uvedené mapě. Tyto informace o GPS jsou k dispozici POUZE na stránkách BillionGraves. Naše technologie vám pomůže najít umístění hrobu a také další členy rodiny, pohřbené poblíž.
Charles Deloy Leavitt was 12 years old when The New York Stock Exchange crashes in what will be called the Crash of '29 or "Black Tuesday", ending the Great Bull Market of the 1920s and beginning the Great Depression. The New York Stock Exchange, is an American stock exchange located at 11 Wall Street, Lower Manhattan, New York City, New York. It is by far the world's largest stock exchange by market capitalization of its listed companies at US$21.3 trillion as of June 2017. The average daily trading value was approximately US$169 billion in 2013. The NYSE trading floor is located at 11 Wall Street and is composed of 21 rooms used for the facilitation of trading. A fifth trading room, located at 30 Broad Street, was closed in February 2007. The main building and the 11 Wall Street building were designated National Historic Landmarks in 1978.
Charles Deloy Leavitt was 22 years old when Adolf Hitler signs an order to begin the systematic euthanasia of mentally ill and disabled people. Adolf Hitler was a German politician, demagogue, and Pan-German revolutionary, who was the leader of the Nazi Party, Chancellor of Germany from 1933 to 1945 and Führer ("Leader") of Nazi Germany from 1934 to 1945. As dictator, Hitler initiated World War II in Europe with the invasion of Poland in September 1939, and was central to the Holocaust.
Charles Deloy Leavitt was 28 years old when World War II: Combat ends in the Pacific Theater: The Japanese Instrument of Surrender is signed by Japanese Foreign Minister Mamoru Shigemitsu and accepted aboard the battleship USS Missouri in Tokyo Bay. The Pacific War, sometimes called the Asia-Pacific War, was the theater of World War II that was fought in the Pacific and Asia. It was fought over a vast area that included the Pacific Ocean and islands, the South West Pacific, South-East Asia, and in China.
Charles Deloy Leavitt was 40 years old when Space Race: Launch of Sputnik 1, the first artificial satellite to orbit the Earth. The Space Race refers to the 20th-century competition between two Cold War rivals, the Soviet Union (USSR) and the United States (US), for dominance in spaceflight capability. It had its origins in the missile-based nuclear arms race between the two nations that occurred following World War II, aided by captured German missile technology and personnel from the Aggregat program. The technological superiority required for such dominance was seen as necessary for national security, and symbolic of ideological superiority. The Space Race spawned pioneering efforts to launch artificial satellites, uncrewed space probes of the Moon, Venus, and Mars, and human spaceflight in low Earth orbit and to the Moon.
Charles Deloy Leavitt was 47 years old when The Beatles make their first appearance on The Ed Sullivan Show, performing before a "record-busting" audience of 73 million viewers across the USA. The Beatles were an English rock band formed in Liverpool in 1960. With members John Lennon, Paul McCartney, George Harrison and Ringo Starr, they became widely regarded as the foremost and most influential music band in history. Rooted in skiffle, beat and 1950s rock and roll, the Beatles later experimented with several musical styles, ranging from pop ballads and Indian music to psychedelia and hard rock, often incorporating classical elements and unconventional recording techniques in innovative ways. In 1963, their enormous popularity first emerged as "Beatlemania"; as the group's music grew in sophistication, led by primary songwriters Lennon and McCartney, the band were integral to pop music's evolution into an art form and to the development of the counterculture of the 1960s.
Charles Deloy Leavitt was 56 years old when Vietnam War: The last United States combat soldiers leave South Vietnam. The Vietnam War, also known as the Second Indochina War, and in Vietnam as the Resistance War Against America or simply the American War, was a conflict that occurred in Vietnam, Laos, and Cambodia from 1 November 1955 to the fall of Saigon on 30 April 1975. It was the second of the Indochina Wars and was officially fought between North Vietnam and the government of South Vietnam. The North Vietnamese army was supported by the Soviet Union, China, and other communist allies; the South Vietnamese army was supported by the United States, South Korea, Australia, Thailand and other anti-communist allies. The war is considered a Cold War-era proxy war by some US perspectives. The majority of Americans believe the war was unjustified. The war would last roughly 19 years and would also form the Laotian Civil War as well as the Cambodian Civil War, which also saw all three countries become communist states in 1975.
Charles Deloy Leavitt was 64 years old when The first launch of a Space Shuttle (Columbia) takes place: The STS-1 mission. The Space Shuttle was a partially reusable low Earth orbital spacecraft system operated by the U.S. National Aeronautics and Space Administration (NASA), as part of the Space Shuttle program. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft of which it was the only item funded for development. The first of four orbital test flights occurred in 1981, leading to operational flights beginning in 1982. In addition to the prototype whose completion was cancelled, five complete Shuttle systems were built and used on a total of 135 missions from 1981 to 2011, launched from the Kennedy Space Center (KSC) in Florida. Operational missions launched numerous satellites, interplanetary probes, and the Hubble Space Telescope (HST); conducted science experiments in orbit; and participated in construction and servicing of the International Space Station. The Shuttle fleet's total mission time was 1322 days, 19 hours, 21 minutes and 23 seconds.


Stg 3 Chick Chick Organic Food. The perfect first snack for Baby's developing gums. This product is manufactured in United States. Freezing and Chilling Temperature of the product is Ambient: Room Temperature.


In our Previous Post QGIS Server – Installation we have talked about the installation process of QGIS Server in Ubuntu and it was easy. In previous post we get the XML file with GetCapabilities working in the browser. In the following sections, we will provide a sample configuration to set up a QGIS Server on Ubuntu with an exemplary QGIS project in QGIS project.
Let us start the process of Adding QGIS Server – Configuration and Deploying QGIS Project.
To provide a new QGIS Server WMS, WFS or WCS, we have to create a QGIS project file with some data. Here, we use the 'airport' shapefile from the local dataset. and for adding the QGIS project with the server we go to the OWS server.
Import layer from Layer > Add Layer >Add Vector Layer.
Customize the layer, Define the colors and styles of the layers in QGIS and the project CRS, if not already defined.
Check the 'Project Properties' under the 'Project' menu, go to the 'OWS server' tab. Below is an example of of how I've set up mine.
and here is the bottom portion of the Properties page.
Ensure under 'Save Paths' in the 'General' Tab it is set to 'relative'. Note that the layers you are going to select for the WMS service are ticked under 'Published' in the WFS capabilities table.
Ensure your url is pointing at 'http://localhost:81/cgi-bin/airport/qgis_mapserv.fcgi?'it is better to specify the full path to the qgis project file which is stored (in my case) in a 'airport' folder inside the 'cgi-bin' folder along with any shapefiles used as the source of your wms, 'qgis_mapserv.fcgi' file and 'wms_metadata.xml' files.
Now in 'Add Layer' dialog select the 'image encoding' to PNG as it the best format with much specific coordinates.
Before we do go back in your QGIS project check you can add your newly created WMS layers back into QGIS as with any other WMS from a different source. When you hit the 'connect' button you should see a list of layers you created earlier, if not go back and check from the beginning of this post.
Select a layer and click 'Add' and the layer(s) should appear in your layer panel as normal qgis layers.
Right Click on your largest area WMS layer and go to 'Properties' and make a note of the bounding box co-ordinates or Layer extent.
Write this above URL in your browser and then you will get a PNG image in your browser with all the attribute data that the shp file had, So the output format will be an PNG image.
here in this part of the url locates the qgis-server executable on the apache2 host server.
This calls the WMS service, it's version and the target spatial reference system as wwe are using ESPG:4326.
this REQUEST part is the request to get the 'map' from the source of the qgis project file that we saved after customization.
this BBOX sets the size of the retrieved image boundary and the 'WIDTH' and 'HEIGHT' of the image area in the browser.
the final part is the description and display of the layers of the WMS. Note there is no 'STYLES' specified because it in specified the .qgs file. Finally, the output format is a png image.
REQUEST=GetFeatureInfo – this request retrieves the underlying attributes and geometry values and pixel location.
GetLegendGraphic – this looks for the view legend information.
bgcolor – sets the background map colour.
This is how we are going to have complete process of how we are Adding QGIS Project to server and configure the server. There are many more formats in which we can get the output data which we will hope to show you in future posts.
Did you tried adding QGIS project file with QGIS server? If you are facing any issue, do let us know by commenting below with the solution.


Brian Powers joins Ray to talk about why you should all use an agent. He also discusses why he got into Hypnosis and entertainment at a really young age. He also shares a legendary bit with a hysterical outcome. All this and more on today's fun interview.


text:
AeroSports Incorporated
Balloon Rides
Why Balloons Do What They Do
Hot air ballooning is the world's oldest form of aviation and air travel. In 1783, the Montgolfier brothers of Annonay, France, made the first successful balloon flight in a balloon filled with smoke from a straw-fed fire. Today, 225 years later, ballooning has become a recreational and competitive sport.
Why do flights take place only in the morning and the late afternoon?
Balloons need stable winds to operate effectively and the hours just following sunrise and approximately 2 hours before sunset are the best for finding these winds. Since balloons move with the air, the weather is very important in deciding to whether or not to fly. The pilot chooses a launch site to use the wind currents to fly towards a suitable landing site.
How is the balloon inflated?
When the time comes to put the balloon up, the envelope is removed from the bag and laid out in a long line. The burners are attached to the uprights, and the basket is attached to the cables on the bottom of the envelope. An engine driven fan is used to inflate the envelope with cold air. When partially inflated, the air is heated by a burner and the envelope rises above the basket. With further heating, there is sufficient 'lift' for the balloon to fly.
What kind of fuel is used for the burners?
To heat the air, the burners are fueled by propane gas, much the same as you probably use in your backyard barbecue grill. The burners do not run continuously; they are only used intermittently to heat the air to maintain the required lift.
How tall are balloons?
Depending on the weight capacity, balloons may be as tall as 100 feet but the average balloon is 70 feet.
How large are hot air balloons?
Most balloons are larger than your house. They hold from 19,000 to 211,000 cubic feet of air and loom from 50 to 90 feet.
How far do balloons fly?
Again...it depends on the wind speed. Hot Air Balloons travel with the wind and an hour flight can carry it up to 15 miles, sometimes more, sometimes less. The balloon also flies at different altitudes. Although the balloon is at the mercy of the wind when it comes to direction, the vertical control of a balloon can be very precise. It is not unusual for our pilots to be able to brush the bottom of the basket across the tops of brush, or inches from the ground A leaf picked from a treetop is a very worthwhile souvenir of the flight!
How high do balloons fly?
Most balloonists enjoy low level flight. The typical balloon flight would be anywhere from treetop level to about 3,000 feet above the ground.
How does the chase crew know where they are?
Radios are used to stay in contact with the chase crew as well as with Air Traffic Control and other aircraft flying in the vicinity.
Who can fly a balloon?
The Federal Aviation Administration issues a Balloon Pilot Certificate to candidates, who pass an FAA written examination, obtain a prescribed number of hours in a balloon, make a solo flight to altitude, pass a flight test, and submit a medical statement.
How do you steer a balloon?
The balloon goes wherever the wind takes it. However, pilots can seek higher or lower altitudes to find wind currents of various directions. We refer to it as the truest form of sailing.
What are the best conditions for flight in a balloon?
A balloon flies better in cooler weather since the hot air gets a better "lift." Balloonists usually fly just after dawn or before dusk, because there is less wind at these times.
Is it cold in a balloon?
At high altitude, it is colder than at ground level, generally 3.5 degrees colder for each 1,000 feet of altitude.
What kind of cloth is the balloon made of?
The colorful envelope is usually made of nylon or polyester, the same type of cloth that parachutes are made of. It is very tightly woven and is coated with a material that makes it very air tight. The nylon is only used to keep the hot air in the balloon. The basket load is transferred by steel or Kevlar cables to a series of vertical load tapes which carry the load. Balloons range in size from about 54,000 cubic feet for a one- or two-person balloon to over 250,000 cubic feet for a balloon capable of carrying a pilot plus eight or ten passengers.
Why is the basket made of wicker?
The wicker basket has proven to be very strong for its weight and is flexible. The wicker is sometimes woven around a steel or aluminum frame, which helps to support the upright posts upon which the burner is mounted. The top rim of the basket and the uprights are usually padded and covered in suede or leather.
What is competition flying?
As in most sports there is a way that you can compete against other balloons in a test of skill. Ballooning is a little different in that it does not rely on speed like most other aircraft. Balloons travel at the same speed as the wind, therefore all balloons travel at approximately the same speed. If there was to be a competition based on airspeed alone, it would be a draw between all competitors.
It is still, however, not that simple. The target is usually identified by a large cross with 30 feet arms. Balloons are approximately 50 feet tall, 35 feet in diameter, and there can be up to 100 in a competition. Now basic math says it is impossible to fit that many balloons at a single target. Because of this, weighted streamers (markers) are used as a substitute for landing. These markers are thrown at the target from any height and the closest marker to the target wins that task. One flight can have up to 4 tasks, which means the pilots and their teams are working overtime to complete the flight with a good point score.
So how do balloons compete?
Balloon pilots compete against each other based on accuracy. The object is to get the closest to a target set by a third party, in this case, the competition director. The closest to the target gets the most points and over several flights this leads to an overall winner.
If you can't steer a balloon, how accurate can you be?
Balloons are amazingly agile aircraft for their size. Although you can't steer them in the conventional manner, you can "steer" them by using different wind directions at different altitudes. Wind direction in not exactly the same as you go up, sometimes there can be minor deviations in direction, at other times there is considerable "steerage" available for the pilot to use. Pilots ascertain this direction through a device called a "windreader" which uses a theodolite hooked to a computer to track the climb rate and direction change of a small helium filled balloon. By using the different directions, top level pilots are amazingly accurate and it is not uncommon to have 20-30 pilots closer than 3 feet from the center of the target from distances as far as 5 miles away.
AeroSports, Inc.
Copywrite 2008/2009 AeroSports, Incorporated

redpajama_set_name: RedPajamaCommonCrawl


text:
Airstrikes hailed a success as Syria threatened with further action
An RAF Tornado taxis into its hangar after landing in Akrotiri and completing its mission. Four Royal Air Force Tornado's took off this morning from RAF Akrotiri to conduct strikes in support of Operations over the Middle East. The Tornados, flown by 31 Squadron the Goldstars, were supported by a Voyager aircraft. At 0200 UK time on 14 April, British forces joined close Allies in a precision strike on Syrian installations involved in the use of chemical weapons. The UK element of the carefully coordinated joint action was contributed by four Royal Air Force Tornado GR4s. They launched Storm Shadow missiles at a military facility ? a former missile base ? some fifteen miles west of Homs, where the regime is assessed to keep chemical weapon precursors stockpiled in breach of Syria?s obligations under the Chemical Weapons Convention. Very careful scientific analysis was applied to determine where best to target the Storm Shadows to maximise the destruction of the stockpiled chemicals and to minimise any risks of contamination to the surrounding area. The facility which was struck is located some distance from any known concentrations of civilian habitation, reducing yet further any such risk.
By Press Association Share
Theresa May is continuing to talk to world leaders in the wake of the bombing campaign in Syria as the US warned it was "locked and loaded" for fresh strikes.
The Prime Minister, Donald Trump and Emmanuel Macron hailed the airstrikes a "success" after chemical weapons facilities were targeted in joint overnight raids.
Russia lost its bid to secure a resolution at an emergency meeting of the United Nations Security Council condemning the "aggression" in Syria.
US ambassador Nikki Haley told the meeting President Trump has warned that America is "locked and loaded" if there is further use of chemical weapons in Syria.
The PM has not ruled out fresh action if Bashar Assad's regime continues to attack its own people.
Mrs May insisted the decision to deploy British cruise missiles in response to the chemical attack in Douma was "both right and legal".
She spent the evening calling world leaders, including key regional figures such as Saudi Crown Prince Mohammad Bin Salman, King Abdullah of Jordan, and President Recep Tayyip Erdogan of Turkey, to explain why she had ordered British military involvement in the US-led strikes.
Damage to the Syrian Scientific Research Centre (SANA/AP)
Mr Trump declared it was "mission accomplished" after the "perfectly executed" operation.
In separate calls, the Prime Minister spoke to the US and French presidents to discuss the offensive and the three leaders agreed it had been a "success", a No 10 spokesman said.
Nato allies have given the action their full support, Secretary General Jens Stoltenberg said.
Foreign Secretary Boris Johnson said Britain had a duty to show that Syria had not "got away with it" and it was standing up against Assad's "barbarism".
In an article for The Sunday Telegraph, he said: "Unless we act there is a risk of moral contamination, a coarsening and corruption of what we have until now thought to be acceptable."
Most voters believe the Prime Minister was wrong to order bombing raids on Syria without parliamentary approval, according to a Survation poll for the Mail on Sunday.
It found that 54% opposed the move compared to 30% who backed Mrs May. But 46% still believed she was better than Jeremy Corbyn on dealing with an international crisis, with just 26% backing the Labour leader.
Speaking in Number 10, Mrs May insisted the action was "legal" and defended the decision to go ahead without securing the backing of Parliament.
She also warned Russia that the airstrikes should act as a warning over its use of chemical weapons.
But she was accused of "riding the coat-tails of an erratic US president" by the Liberal Democrats, and "taking instructions" from Washington by Labour.
Four Royal Air Force Tornado GR4s joined the co-ordinated missile strikes at 2am, launching Storm Shadow missiles at a base 15 miles west of Homs.
Mrs May said the Cabinet had taken advice from the Attorney General, National Security Adviser and military chiefs when it met on Thursday.
She added: "We agreed that is was both right and legal to take military action together with our closest allies."
Mr Corbyn said the military action against Syria was "legally questionable" and makes real accountability for war crimes less likely.
Survation interviewed 2,071 people online on Saturday for the Mail on Sunday.
Main photo: Ministry of Defence Crown copyright 2018
'More than 1.2m deaths from antibiotic-resistant infections worldwide in 2019'
Crackdown launched on 'poor' uni courses – with fines and ratings system planned
Partygate: Boris Johnson clings on despite demand to 'in the name of God, go'


The Northeast Kingdom Is a Great Place to Visit and Play!
Vermont's Northeast Kingdom Is Beautiful Year Round!
Vermont's Northeast Kingdom is, without a doubt, the state's most beautiful and undisturbed region. Coined more than 60 years ago, the Northeast Kingdom - comprised of Caledonia, Essex and Orleans counties - received its nickname in honor of its sheer splendor. A beloved former governor and U.S. senator, George Aiken, proclaimed this area so spectacular that it felt like a kingdom of old, a Northeast Kingdom, he said. The name stuck.
The best part of the Northeast Kingdom is, actually, what it does not offer. You will not find any traffic jams or urban sprawl here. You can actually witness an extraordinary sunrise from your back door and see every star in the sky on a clear night.
The images of the Northeast Kingdom are very clear and recognizable – church steeples rising to the sky, steam rising from sugarhouses, the smell of newly hayed fields and the vision of beautiful fall foliage. Even those who have lived here their entire lives do not tire of the views.
So many comment that the Northeast Kingdom is, truly, a special place, that the clean air and the quiet of the night make it easier to sleep, that you can view rocks on lake bottoms as clear as day because the water is so clear and the landscape really is as lushly green as Ireland in the summer. There are precious few places where you can actually hear the breeze rustle through trees, and the Northeast Kingdom is such a place.
Whether you plan your own stay with our online trip Itinerary or contact us for suggestions, we are here to help, as we want you to have the best vacation ever in our wondrous region. If you click on "Find A Business," located on every page of our web site, you will find it to be a great guide to discover accommodations, restaurants, businesses and regional information.
Riverglen House offers private apartments; all have kitchenettes/full baths, 3 meals a day with 6 entree choices each meal, housekeeping services, dynamic daily activities program and 24-hour on-site caregivers. Long-term and short-term care.


Creating Arctic Kiss - Join Jerry LoFaro as he creates an amazing illustration using Photoshop. Strating from scratch and using the many applications that Photoshop contains, you'll get first-hand instruction on using this dynamic software.
About the Author: Jerry LoFaro is an award-winning illustrator whose client list includes: Random House, Harcourt, Ballentine, Avon, Bantam, Time Life, and Viking Penguin, Celestial Seasonings, Coca-Cola, Barcardi, Aflac, Levi's, Disney, Claritin, National Geographic, Nike, Panasonic, Kellogg's, IBM, and many more.
Box Dimensions (LxWxH) 7.4 x 5.2 x 0.6"
DVD:Creating Arctic Kiss with Jerry LoFaro is rated 5.0 out of 5 by 1.


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TechInnovation 2016 bridges the gap between business enterprises and technology providers
International MNCs, SMEs and technology seekers explore fresh ideas for collaboration through open innovation
SINGAPORE, 18 August 2016 – Singapore's premier technology brokerage event, TechInnovation, is set to bridge the gap between enterprises and technology providers. Organised by IPI Singapore, TechInnovation will host more than 70 international speakers, business leaders, R&D heads as well as technology seekers.
The conference will be headlined by three keynote sessions.
Gregg Carpenter, Global Director of Engineering at The Coca-Cola Company, will discuss Coke's formula for developing and integrating disruptive technologies;
Dr Reza Ghahary, Director Innovation Networks & Communication at Evonik Industries AG, will share Evonik's challenges, best practices and examples of Open Innovation; and
Xander Sim, Chief Technology Officer at Cell ID Pte Ltd, will demonstrate how Cell ID has redefined the boundaries of traditional printing technology and developed an affordable, roll-to-roll printable platform that could reproduce various diagnostics kits through conventional printing technology.
"TechInnovation aims to help SMEs expand their opportunities for collaboration. This year, we have introduced a brand new segment to foster Singapore-Europe partnership opportunities with the Enterprise Europe Network (EEN). This segment will connect technology seekers with European SMEs which are developing innovations in sectors such as nano-technology, ICT, Environment, Healthcare and Energy," said Professor Lam Khin Yong, Executive Director of IPI.
Five EEN partners from Europe will introduce innovation and business opportunities from their regions. The speakers include Jordi Maluquer de Motes, Director, Singapore at the Catalonia Trade & Investment from Spain and Juan Carmona-Schneider, Senior Consultant and Sector Group Chair Healthcare Enterprise, Europe Network at ZENIT GmbH from Germany.
The search for technology commercialisation and co-development opportunities heats up at TechInnovation's Crowdpitching sessions, which spans sectors such as Service & Digital Economy, Advanced Manufacturing & Engineering, Health & Personal Care, and Urban Solutions & Sustainability. The crowdsourcing sessions will feature 16 global and local speakers including Wong Wai Meng, Chief Executive Officer at Keppel Data Centres; Joaquim Llorente, Chief Innovation Officer at Zobele Group; Dr Sarah Chan, Strategic Foresight Manager, Asia Pacific at L'Oréal; and Donald Lum, Assistant Vice President, Technology at SATS Limited, among others.
TechInnovation's Platform Technologies and Applications panels will feature two tracks:
Smart Nation – IoT Security: Smart Cities, SECURED Nations, will feature industry leaders including Cort Isernhagen, Managing Director, Asia Pacific at Lux Research; Subho Halder, Co-Founder and Chief Technology Officer at Appknox and Dr Andreas Hauser, Director, Digital Services at TÜV SÜD Asia Pacific.
Additive Manufacturing: Appreciating Design Principles and Strengths of Additive Manufacturing, will feature speakers such as Christian-Friedrich Lindemann, Research & Exploitation Manager, Direct Manufacturing Research Centre (DMRC) and Dr Ho Chaw Sing, Managing Director, National Additive Manufacturing Innovation Cluster (NAMIC).
TechInnovation 2016 will take place from 20 to 21 September 2016 at Resorts World Convention Centre in Sentosa. For more information on TechInnovation and its programme, please visit www.techinnovation.com.sg.
About TechInnovation
TechInnovation is a premier industry-technology matching event that is organised by IPI Singapore. TechInnovation brings together international technology providers and enterprises to explore technology commercialisation and initiate business collaboration through open innovation. It is a leading conference and exhibition in Singapore that focuses on the matching of industry's needs to enabling technologies in info-communications & electronics, manufacturing, materials & chemicals, health & personal care, medtech, energy and environment from global sources.
More information on TechInnovation can be found www.techinnovation.com.sg.
IPI was established by Singapore Ministry of Trade & Industry in April 2011, to catalyse and enable enterprises to grow their business through the use of technology and innovation. IPI promotes Open Innovation and works with enterprises to source for technologies locally or from aboard; and facilitate partnership to bring new and innovative products and services to the market. As a recent member of the Enterprise Europe Network (EEN), IPI is well-positioned to assist Singapore enterprises to discover new business and innovation opportunities and expand their reach through its EEN partners.
For more information about IPI, please visit www.ipi-singapore.org.
Selena Sheikh
Director, PINPOINT Public Relations
selena@pinpointpr.sg
Charlene Boh
Senior Manager, Marketing & Communications
DID: +65 6419 6600, Mobile: +65 9767 7792
charlene-boh@ipi-singapore.org
Harness the Potential and Capabilities of Additive...
TechInnovation Features over 300 Technologies Under One Roof


Locals and visitors shop 'til they drop on Greenville's Eastside. Specialty shops meet almost every need, while large retailers and nearby Haywood Mall are popular destinations. Dining options abound as well; the area boasts an eclectic array of restaurants representing a United Nations of cuisines. It's centrally located too, with easy access to interstates 85 and 385. And downtown Greenville is just a 15-minute drive from most parts of the Eastside. Housing is available in a mix of established neighborhoods, new subdivisions, or apartments to rent, in a variety of price ranges.
Established homes at various prices; some newer construction.
Suburban communities with good schools, easy access.
Convenience to highways, shopping centers and airport.
Recreation, outdoor activities, children's activities.
Recreation options abound, including Butler Springs Park, with its athletic fields and paved walking trail; and Oak Grove Lake Park, which has a fishing lake. Greenville Rec's Pavilion boasts an all-new ice surface for hockey, ice skating, curling and more. The facility also has a boundless playground offering recreational opportunities for all.
Greenville County Library's F.W. Symmes Branch on Pelham Road is an anchor of the Eastside, with 12,000 square feet of space and a 100-seat meeting room. It's open six days a week.
Health care is easily accessible, with numerous doctor's offices, urgent-care centers, and Eastside campuses for both Bon Secours St. Francis and Greenville Health System.
Schools serving the Eastside include Buena Vista Elementary, Lake Forest Elementary, Pelham Road Elementary, Greenville Middle Academy, League Middle, Northwood Middle, Eastside High and Wade Hampton High.


text:
El accidente del Sukhoi Su-30 ocurrió alrededor de las 17:30 hora local del 23 de octubre de 2022 en la ciudad de Irkutsk, en el sur de Rusia. El avión Su-30SM estaba realizando un vuelo de prueba cuando cayó sobre un edificio residencial de madera de dos pisos en 2nd Sovetsky Lane. Ambos pilotos murieron. Los residentes de la casa no resultaron heridos ya que no estaban en casa.

El accidente ocurrió seis días después de que otro avión se estrellara contra un edificio residencial en Yeysk. Los corresponsales de la BBC señalaron que ambos aviones pertenecen en general a la misma familia: fueron creados mediante una profunda modernización del caza soviético Sukhoi Su-27.

Accidente
En la noche del 23 de octubre de 2022, se realizaron vuelos de prueba de dos Su-30SM sobre el aeródromo de Irkutsk-2. Un avión aterrizó sin problemas en el aeropuerto, mientras que se perdió el contacto con el otro avión.  El avión se estrelló contra un edificio residencial en 2nd Sovietsky Lane. Las cinco personas (dos familias) que vivían en la casa no estaban en el momento del accidente. Dos pilotos del avión murieron. Posteriormente se produjo un incendio que hirió a un bombero. Según autoridades locales, 150 casas quedaron sin luz tras el accidente aéreo.

Tripulación
 Maxim Vyacheslavovich Konyushin: un piloto de pruebas profesional. Participó en las pruebas de más de 30 modelos de aviones. Nacido enPrimorie. Se graduó de la Academia de Ingeniería de la Fuerza Aérea Zhukovsky con un título en pruebas de aeronaves. Fue galardonado con medallas del Ministerio de Defensa de la Federación Rusa "Por Distinción en el Servicio Militar" III, II y I grado. Llevaba el título de "Piloto de Pruebas de Honor de la Federación Rusa".
 Viktor Viktorovich Kryukov: piloto de pruebas de tercera clase, piloto militar de segunda clase. Nativo de Ucrania. Graduado del Instituto de Aviación Militar de Krasnodar.

Investigación
El Comité de Investigación de Rusia abrió un caso penal en virtud del artículo 263 del Código Penal ("Violación de las normas de seguridad del tráfico y operación del transporte aéreo"). Se ha creado una comisión para investigar el accidente. En el distrito de Leninsky de Irkutsk, se introdujo un régimen de emergencia municipal.

La investigación considera dos versiones de las causas del desastre: errores de la tripulación y falla del equipo. Se informa que la tripulación pudo haber perdido el conocimiento durante el vuelo por un mal funcionamiento del equipo de oxígeno o despresurización.

Referencias

Accidentes e incidentes aéreos en Rusia
Accidentes e incidentes aéreos de 2022
Rusia en 2022
Accidentes e incidentes de aviones militares
Transporte de Irkutsk

redpajama_set_name: RedPajamaWikipedia


Call to Service at St. Mary's Abbey!
Delbarton prides itself on the vast number of service opportunities for students and their families to get involved in throughout the year. However, some programs are often overlooked due to lack of advertising and information. In particular, the programs within St. Mary's Abbey are in need of member participation. Nonetheless, Saint Mary's Abbey is always looking for lectors, cantors, and altar servers to help celebrate weekly mass. Masses take place on Sunday mornings when most Delbarton Students (who are Catholic) go to church anyway. Getting involved in the Mass at Delbarton has been one of the most rewarding experiences of my Delbarton career.
I have been cantoring for Mass intermittently since my sophomore year. I believe that one of the main reasons that many students find it hard to do service is because they have not found their passion in the service. By contrast, the reason that some of my brothers and I keep coming back week after week is because not only do we feel like we are fulfilling our duty of service, but we find passion and fulfillment in serving the congregation, the monks at the Abbey, and most importantly, serving the Lord.
At the Abbey, there are many different positions that welcome partipants every week. The organist, Mr. Hatcher, is always looking for cantors and or a choir for Masses. He is available during the week to teach that week's music during an M-Block, and for a full sing-through at ten o'clock on the morning of the Mass. For any student looking to increase their vocal or instrumental performance experience, cantoring or playing at mass is an excellent opportunity to read, learn and perform an often underappreciated style of music, liturgical hymns. If singing or playing is not a student's strength, one can also be a lector. Service does not get any easier than reading a passage fluently, clearly, and slowly to spread the Lord's message to the congregation. Although, if any performance at all is overwhelming for a student, the Abbey Altar Association (A.A.A.) is a group of young men who work with Fr. Edward to serve mass weekly. The information network is on Schoology, where students can reach out according to their interest and availability. No experience is necessary; A.A.A. can provide training for new altar servers.
These three groups are always in need of volunteers, since many people have commitments that coincide with Sunday morning mass. Saint Mary's Abbey needs students to help especially around special celebrations (Advent, Christmas, Holy Week). It is my hope that Saint Mary's Abbey continues the tradition of using volunteer students in important roles for the celebration of the mass. For students looking for meaningful service while growing closer to God, I highly recommend getting involved!
"Whatever you are doing that makes you feel the most alive… that is where God is"- St. Ignatius.


Dr. Sara Finney is Professor in the Department of Graduate Psychology and Senior Assessment Specialist at James Madison University. She is also Associate Director of the Center for Assessment and Research Studies at JMU, providing support to Student Affairs programs assessing student learning and development outcomes. Her research focuses on examinee motivation and reactions to testing, on the use of structural equation modeling to gather validity evidence for score interpretations, and on the merger of implementation fidelity data and student learning outcomes data when assessing program effectiveness.
Dr. Finney has won awards for outstanding mentorship from the Conference of Southern Graduate Schools, the Northeastern Educational Research Association, and the Provost of James Madison University. She is proud of the fact that approximately 75% of her over 50 research publications have student co-authors. Those articles have appeared in the Journal of Educational Psychology, Educational Assessment, Applied Measurement in Education, Journal of Experimental Education, International Journal of Testing, Journal of Personality Assessment, Contemporary Educational Psychology, Measurement and Evaluation in Counseling and Development and other journals and edited volumes. She serves on the editorial boards of Educational and Psychological Measurement, Journal of Educational Psychology, Educational Assessment, International Journal of Testing, and Journal of Experimental Education. She also serves on the Impact Research Advisory Council for the Learning Service & Insights Group at Macmillan Learning, and is chair of the Technical Advisory Committee for the Graduate Record Examinations Program at the Educational Testing Service.
Dr. Finney has a bachelor's degree in psychology from the University of Wisconsin at Eau Claire, and both a master's and a Ph.D. in quantitative and qualitative methods from the University of Nebraska.


The companies announced the merger news on December 11, 2015. They discussed the merger through a conference call with analysts. According to management, the logic behind the merger is to achieve a leadership position in each product segment. With a focused approach, it plans to increase the revenue growth by leveraging its vast client base and geographical reach. It plans to improve the productivity and margins through significant cost synergy. The merged company's market capitalization was ~$130 billion as of December 11, 2015. Initially, the merger news came around three days ago when the Wall Street Journal published this news. Investors welcomed the deal. Dow and DuPont's stock rose 12% the day after the merger news on December 9, 2015.
DuPont's shareholders will receive 1.3 shares of DowDuPont for every DuPont share while Dow's shareholder will get one share of DowDuPont for each Dow share.
DowDuPont will be divided into three independent publicly traded companies on the basis of its product portfolio—agricultural, materials and sciences, and specialty products.
Dow's current chairman, Andrew N. Liveris, will be the chairman. DuPont's Edward D. Breen will be DowDuPont's CEO.
DowDuPont will have 16 directors. It will have eight directors each from Dow and DuPont.
DowDuPont will set up an advisory committee for each separate entity—agriculture, material science, and specialty products.
This merger transaction is expected to close in the second half of 2016. It's subject to shareholders and regulatory approvals.
In August 2015, Monsanto (MON)—the leading agriculture chemical player—was about to acquire the European chemical player Syngenta AG (SYT) for $46 billion. However, the deal didn't materialize due to resistance from Syngenta. Over the last couple of years, Dow and DuPont have been under immense pressure from their shareholders to divest their lower margin businesses. They were pressured to increase their focus on higher margins and growing businesses like specialty products. Therefore, both DuPont and Dow have been looking for potential merger and acquisition deals—primarily for their agricultural chemicals businesses. Initially, DuPont was negotiating a deal for its agriculture segment with Syngenta and Dow Chemical. This unexpected merger news came later. Investors welcomed the deal. To learn more about the companies, read Market Realist's overview series on Dow Chemical and DuPont.
The Materials Select Sector SPDR ETF (XLB) largely tracks the performance of major chemical players. The iShares U.S. Basic Materials ETF (IYM) tracks the performance of US-based basic material companies including chemical. Dow Chemical and DuPont form 22% of XLB's total holdings.
After the merger, DowDuPont will spin off into three independent and public companies—agriculture, material science, and specialty products.
Netflix is focusing on original programming, and it's looking to Disney to provide this content. Disney's ABC Studios struck an original content deal with Netflix in the fall of 2013.


When it comes to writing winning essays, there are basic things which every student must always have at the back of the mind and one of them is a good topic. The moment you miss out on this, you can be rest assured of poor grades at the end of the school term. But who wants to perform dismally with all the information out there? The age of the internet has changed many a student's perspective in matters pertaining to information seeking. You've got to appreciate the power of the internet when it comes to academic these days but most importantly, embrace it fully. A lot of students are however finding it even challenging using the internet to understand or even search for information relating to types of essays one can be assigned in college.
Should grants given to high school students be increased?
How should policy makers in education handle the problem of slang in languages?


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Category Archives: PTH Receptors
The elutions and washes were analyzed by reducing SDS-PAGE
The elutions and washes were analyzed by reducing SDS-PAGE. ligands can tune the anti-cancer ramifications of metallodrugs and help elucidate the molecular system of medication activity. Of the many alternatives to platinum-based medicines evaluated to day, ruthenium complexes furthest possess advanced, with two ruthenium(III)-centered compounds, specifically indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and imidazolium trans-[tetrachloro(dimethylsulfoxide)(1H-imidazole)ruthenate(III)] (NAMI-A), having been examined in clinical tests6C10. Ruthenium(III) complexes, nevertheless, are inclined to ligand exchange reactions in aqueous press/physiological buffer which hamper, somewhat, the rational style of new substances with relevant therapeutic properties. As a result, ruthenium(II)-arene compounds possess attracted considerable interest following motivating data on two prototypical substances, i.e. [Ru(6-cells28. Following studies determined a manageable amount of strikes from tumor cell lines, i.e. 2029, related to proteins involved with a accurate amount of pathways, such as mobile energy metabolism, change, morphologic and apoptosis maintenance, and so are difficult to rationalise as focuses on versus downstream results therefore. Indeed, additional tests possess recommended how the fairly low amount of strikes may have been because of recognition restrictions and, as a result, as technology improved, proteomics strategies shortlisted a huge selection of proteins revised in cells after cisplatin publicity30. Recently, filtering strategies present a manageable amount of strikes that Compound W show up significant. However, oftentimes the analytical achievement takes a prior understanding of the medication focus on as well as the time-course advancement from the downstream impact. For example, using a mix of isotope cell and labelling routine stage selection, proteomic evaluation of cisplatin-induced apoptosis entirely cell lysates determined 26 proteins considerably upregulated which nearly all proteins31 identified had been regarded as associated with apoptosis and of the almost half got at least one RNA-binding theme. Another study centered on medication resistance to recognize protein strikes consistent with manifestation of defence elements that shield cells from drug-induced harm32, like the Nrf2 mediated oxidative tension response, mitochondrial procedures, protein kinases like the focuses on of rapamycin (mTOR) and AMPK. Furthermore, specific pathways had been transformed by cisplatin, including eIF2 signalling of protein synthesis, actin nucleation via the ARP/WASP rules and organic of Compound W cell polarization33. In each full case, the data will not differentiate between immediate cisplatin focuses on and downstream occasions, but shows potential mixture therapy objectives that may be used to boost the Compound W therapeutic result of cisplatin treatment, for instance, mixture therapy with rapamycin34, 35. Integrating quantitative pathway evaluation (qPA) techniques enables the amount of strikes from filtered proteomics solutions to become rapidly obtained by relevance. With camptothecin, qPA decreased the real amount of strikes towards the known camptothecin focus on, TOPI, from just a small number of putative focuses on. Importantly, Compound W recognition was feasible without biasing the evaluation towards known focuses on within the insight data36. This technique continues to be advanced by presenting cell routine stage selection further, predicated on the observation that in past due apoptosis KLRK1 the great quantity modification in protein focuses on of the small-molecule medication is apparently unexpectedly large in comparison to additional co-regulated proteins37. The mixed method, called Practical Identification of Focus on by Manifestation Proteomics (FITExP)37, uses protein manifestation data from at least two different cell lines that Compound W are referenced against positive settings, to allow the prediction of the very most likely protein focuses on of a little molecule. This process overcomes.
This entry was posted in PTH Receptors on December 13, 2021 by Francis Hughes.
Moreover, AILD individuals may possess a poor prognosis, especially those with an incomplete response to first-line treatment
Moreover, AILD individuals may possess a poor prognosis, especially those with an incomplete response to first-line treatment. based on work in animal and clinical studies. We also discuss the difficulties of MSC therapy in medical applications. In summary, although encouraging data from preclinical studies are Gabapentin Hydrochloride now available, MSC therapy is currently much for being applied in medical practice, therefore developing MSC therapy in AILD is still demanding and warrants further study. the Fas/FasL pathway.46 MSCs Anpep were also known to exert an effect within the differentiation of CD4+ T cells. Specifically, MSCs can inhibit na?ve CD4+ T cells from differentiating towards T-helper 1 (Th1) and T-helper 17 (Th17) cells, but can promote the differentiation of CD4+CD25+FOXP3+ (forkhead package P3) regulatory T cell (Treg) and IL-10+ Treg cells.47,48 MSC could secrete TGF- and activating Smad2 (SMAD family member 2) signaling, which is important for Treg regulation, thus promoting the process of Treg differentiation.49 Evidence showed that MSC therapy in an experimental autoimmune encephalomyelitis model led to an increase in the Treg population and a decrease in the Th17 population, which ultimately resulted in amelioration of the disease. 48 B cells MSCs can also affect B-cell immune reactions. Early studies suggested that MSCs could inhibit the proliferation of B cells by arresting the cell cycle in the G0/G1 phase and by interesting programmed cell-death protein 1 (PD-1)/PD-L1 pathway direct contact.50,51 Moreover, MSCs could suppress the production of immunoglobulin G1 (IgG1) and IgM during B-cell terminal differentiation in mice.52 The underlying mechanisms associated with these effects have also been explored. MSCs could secrete CCL2 (C-C motif chemokine ligand 2), which inhibits transmission Gabapentin Hydrochloride transducer and activator of transcription 3 (STAT3) activation and promotes combined package 5 (PAX5) manifestation in plasma cells, therefore suppressing Ig production in B cells.53 IL-1 receptor antagonist (IL-1RA) and olfactory 1/early B-cell factor-associated zinc-finger protein (OAZ) will also be important molecules with this immunoregulation process.54,55 Schena and has exhibited therapeutic effects in several liver fibrosis animal models induced by carbon Gabapentin Hydrochloride tetrachloride (CCL4) or thioacetamide (TAA), and in several clinical trials. Swelling is a strong pathogenic factor in liver fibrosis. Since MSCs have a considerable impact on the immune system, the connection between MSCs and immune cells has been widely investigated in liver fibrosis. Macrophages can activate fibrogenic myofibroblasts by secreting TGF-1 and play a pathogenic part in liver fibrosis. Co-culturing MSCs with colony-stimulating element-1-induced macrophages could induce macrophage development toward the anti-inflammatory M2 phenotype Gabapentin Hydrochloride with higher phagocytic activity conferred through elevated manifestation of PGE2 and TSG-6. Combining MSCs with macrophages was shown to reduce the degree of liver fibrosis more efficiently than MSC monotherapy, and also resulted in higher levels of antifibrotic factors such as matrix metalloproteinases (MMPs) and pro-regenerative factors such as vascular endothelial growth factor.76 MSCs could also induce M2-type macrophages increasing IL-4 and IL-10 levels, by promoting the mobilization of macrophages both and the production of IDO, leading to attenuation of liver fibrosis.78 HSCs play a vital role in the pathogenesis of liver fibrosis. MSCs have been shown to suppress the manifestation of Delta-like 1 (Dlk1), which is an HSC activator and promotes liver fibrogenesis, thereby ameliorating liver fibrosis.79 Besides, Meier their anti-inflammatory effects, indirectly, and inactivation of HSCs, directly. Functions of MSCs in hepatocyte differentiation The immunoregulation and anti-fibrosis properties of MSCs are critical for hepatocyte survival. MSC therapy offers been shown to protect the acutely hurt liver by directly inhibiting hepatocellular apoptosis and revitalizing cells regeneration.85 Moreover, MSC can repair liver tissue damage by differentiating into hepatocytes and replacing injured cells, thereby restoring liver function.30 Schwartz studies, the ability of MSCs to differentiate into hepatocytes has also been investigated the tail vein one to three times on days 21, 28, and 35 according to the different group settings. One group of EAH mice was given prednisolone and AZA like a positive control. The EAH mice that received MSCs experienced attenuated ALT and AST (aspartate aminotransferase) levels, and improved liver histological scores. They also found that the levels of PD-L1 in the liver and serum of EAH mice were higher than those in the normal control mice, and the level of PD-L1 gradually improved with increasing period of MSC treatment. It is generally believed that an elevated level of PD-L1 takes on an anti-inflammatory role in inflammatory diseases, thus, this result indicated that MSCs could increase the PD-L1 level to inhibit inflammation.101 In contrast, the level of.
This entry was posted in PTH Receptors on September 26, 2021 by Francis Hughes.
MDSCs are expanded in AML and donate to tumor-related immune suppression
MDSCs are expanded in AML and donate to tumor-related immune suppression. to a Th2 phenotype. We hypothesized that this expansion of MDSCs in AML is usually accomplished by tumor-derived extracellular vesicles (EVs). Using tracking studies, we exhibited that AML EVs are taken-up myeloid progenitor cells, resulting in the selective proliferation of MDSCs in comparison with functionally qualified antigen-presenting cells. The MUC1 oncoprotein was subsequently identified as the critical driver of EV-mediated MDSC expansion. MUC1 induces increased expression of c-myc in EVs that induces proliferation in the target MDSC population via downstream effects on cell cycle proteins. Moreover, we demonstrate that this microRNA miR34a acts as the regulatory mechanism by which MUC1 drives c-myc expression in AML cells and EVs. Introduction Acute myeloid leukemia (AML) is usually a lethal hematologic malignancy affecting over 21?380 people in the United States every year.1 AML arises in the context of a bone marrow microenvironment characterized by an immunosuppressive milieu that fosters tumor growth and immune escape.2 Critical elements of this environment include increased presence of accessory cells with an inhibitory phenotype that polarizes cells toward a tolerizing phenotype.3 LY2140023 (LY404039) Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells with potent immune-suppressing activity.4 Increased presence of MDSCs is associated with tumor progression,5 poor outcomes,6 and decreased effectiveness LY2140023 (LY404039) of immunotherapeutic strategies.7 MDSCs are characterized by the expression of the myeloid markers CD11b and CD33 and absent HLA-DR.8 Two distinct subsets have been further characterized: monocytic MDSCs, with the phenotype CD15?, and granulocytic MDSCs, that are CD15+.4 Although both subtypes have been identified in healthy patients,9 levels are increased in patients with solid malignancies10 and premalignant conditions.11,12 MDSCs exert diverse effects in modulating the interactions between immune effector cells and the malignant cells. MDSCs suppress effector Compact disc8+ T cells via T-cell receptor downregulation straight, mediated with the expression from the enzymes arginase-1 and inducible nitric oxide synthase and by the creation of reactive air species.4,13 Although increased amounts of distinct MDSCs have already been reported in sufferers with myelodysplastic symptoms clonally,12 the function of MDSC populations or their function in AML is not very well elucidated. Of take note, immature myeloid cells such as for example MDSCs talk about common features with myeloid leukemia cells due to the first maturation arrest of leukemic cells. For instance, it has been suggested that AML blasts exert their suppressive effects on T cells via a comparable arginase-1Cdependent mechanism to MDSCs.14-17 These observations lead us to investigate the presence and importance of MDSCs in AML and the critical pathways underlying their accumulation and function. In particular, we investigated the mechanisms of intercellular signaling between the AML tumor cell and the surrounding cells of the immune microenvironment, including LY2140023 (LY404039) MDSCs. The primary mediator of MDSC growth in the setting of malignancy is usually thought to be tumor secretion of inflammatory cytokines such as tumor necrosis factor alpha,18,19 interleukin-1B (IL-1B),20 IL-12,21 IL-18,22 and IL-6.9 More recently, tumor-secreted extracellular vesicles have been demonstrated to be an important mediator of MDSC expansion.23,24 Extracellular vesicles (EVs) are membrane-bound vesicles released ubiquitously by cells and are thought to be important mediators of intercellular communication.25 EVs have a complex Cd33 nomenclature, which includes the terms exosomes, microvesicles, and oncosomes, defined by size and ranging from 40 to 1000 nM.26-28 Although their biological relevance in cancer has yet to be fully elucidated, it is generally agreed that they carry biologically relevant proteins, messenger RNAs (mRNAs), and microRNAs.28 It has been exhibited that AML cells release membrane-bound extracellular vesicles,29-32 LY2140023 (LY404039) which transfer microRNAs.
This entry was posted in PTH Receptors on February 17, 2021 by Francis Hughes.
Supplementary Materials Supplemental Materials supp_28_14_1924__index
Supplementary Materials Supplemental Materials supp_28_14_1924__index. highly associated with enhanced speed and persistence Bmp6 of directional movement. Strikingly, WRAMP structures form transiently, with cells displaying directional persistence during periods when they are present and cells changing directions randomly when they are absent. Cells appear to pause locomotion when WRAMP structures disassemble and then migrate in new directions after reassembly at a different location, which forms the new rear. We conclude that WRAMP structures represent a rear-directed cellular mechanism to control directional migration and that their ability to form dynamically within cells may ML-323 control changes in direction during extended migration. INTRODUCTION ML-323 Cell movement requires the spatial control of signal transduction, including cell polarity mechanisms that move proteins to specific intracellular locations (Huttenlocher, 2005 ; McCaffrey and Macara, 2012 ). During cell locomotion, cells must coordinate the formation of membrane protrusions and attachments to extracellular matrix at the front, with membrane retraction and disassembly of attachments at the rear. Much is known about events at the leading edge, where actin polymerization via Rac, Cdc42, WASP/WAVE, and Arp2/3 form membrane and lamellipodia protrusions, which promote focal get in touch with accessories to extracellular matrix and mediate ahead motion (Ridley 0.01. The ideals were determined using regular two-tailed Students check. The word polarized with this figure will not distinguish between back and front side polarity. WRAMP constructions had been quantified by immunostaining of endogenous MCAM and myosin IIB and phalloidin staining of F-actin. Treatment of cells for 30 min with Wnt5a improved the percentage of cells displaying WRAMP constructions considerably, which improved by 2.5- to 3-collapse as assessed by polarized localization of MCAM (Shape 1C). Typically, WRAMP constructions type within 15 min, but quantified at an individual time stage, they come in just 24% of WM239A and 15% of A375 cells. That is described by their transient character; they dynamically assemble, accompanied by disassembly. When assessed over an interval of 0?2 h, 80% of cells formed WRAMP constructions (unpublished data). Around 20% of WM239A cells and 12% of A375 cells demonstrated F-actin polarized along with MCAM after Wnt5a treatment (Shape 1D). Consequently F-actin was within 80% of WRAMP constructions based on polarized MCAM. We also found myosin IIB polarized at WRAMP structures in 50% of cases (Figure 1E). F-actin was present ML-323 in almost all of the WRAMP structures with myosin IIB (Figure 1F). Thus WRAMP structures were characterized by strong association between polarized MCAM, F-actin, and myosin IIB, forming with coordinately increased frequency in response to Wnt5a. WRAMP structure formation involves coordinated movement of MCAM, F-actin, and myosin IIB Confocal live cell imaging was used to examine the order of MCAM, F-actin, and myosin IIB recruitment into WRAMP structures. In both WM239a and A375 cells, MCAMCgreen fluorescent protein (GFP) polarized dynamically to form WRAMP structures and was always followed by membrane retraction (Figure 2, A and B). Cells were also cotransfected with MCAM-GFP and mCherry in controls, which confirmed that the polarized localization of MCAM-GFP was not an artifact caused by variations in cell volume or membrane thickness (Supplemental Figure S1). We then examined 100 cells cotransfected with MCAM-GFP and LifeAct-mCherry, a peptide that binds and labels F-actin. In each case, the accumulation of F-actin into WRAMP structures was synchronous with the polarization of MCAM-GFP (Figure 2, A and B). WM239a cells migrated in a manner that reflected spreading and adhesiveness reminiscent of mesenchymal cell movement, whereas A375 cells migrated with more-rounded morphologies. Nevertheless, the temporal dynamics of F-actin and MCAM-GFP in forming WRAMP structures were tightly coordinated in each cell type. Open in a separate window FIGURE 2: Dynamic motion of WRAMP constructions, accompanied by membrane retraction. Structures from confocal live-cell imaging tests of (A) WM239a and (B) A375 cells cotransfected with MCAM-GFP and LifeAct-mCherry and (C) WM239a and (D) A375 cells cotransfected with MCAM-GFP and myosin IIB-N18-mCherry. Supplemental Films S2CS5 (related to ACD, respectively) display coordinated motion of MCAM, F-actin, and myosin IIB. White colored dot indicates beginning position. Scale pubs, 10 m; moments in hours:mins. Settings because of this test out MCAM-GFP in addition mCherry in Supplemental Shape Supplemental and S1 Films S6 and.
Percutaneous coronary intervention has turned into a mainstay in the management of coronary artery disease
Percutaneous coronary intervention has turned into a mainstay in the management of coronary artery disease. individuals of novel oral anticoagulants. Indeed, a individualized and flexible approach to oral antiplatelet therapy in seniors individuals undergoing percutaneous coronary treatment is normally paramount, factoring individual features (exploiting thrombotic, blood loss BIRB-796 inhibition and frailty ratings), triage (including when suitable noninvasive evaluation of anatomic and useful need for coronary artery disease), various other and angiographic intrusive imaging features, interventional technique, stent choice, treatment, and secondary avoidance. simply no pretreatmentDAscenzo201424627967549,586MA of non-RCTsDAPT discontinuation continuation after PCIElliott20193137690516NAURShort long-term DAPT after PCIKhan20182959607856,239MA of RCTsPPI simply no PPCI with DAPT after PCILane20132388005753187,502MA of RCTs and non-RCTsCombined antiplatelet and anticoagulant therapy in atrial fibrillationMisumida2018302259781012,696MA of RCTsShort long-term DAPT after PCIVries2016262727313819,667SR of non-RCTsPlatelet function research, genetic examining, and blood loss risk with DAPTZhang20193062900235,387MA of RCTsDAPT TAT after PCI Open up in another screen DAPT, dual antithrombotic therapy; MA, meta-analysis; NA, not really suitable; PCI, percutaneous coronary involvement; PPI, proton pump inhibitor; RCT, randomized scientific studies; TAT, triple antithrombotic therapy; UR, umbrella review. Desk 2 Internal validity of included testimonials based on the Oxman and Guyatt Review Quality Evaluation Questionnaire conducted an intensive organized review on 38 observational research including 19,667 sufferers getting dual antiplatelet therapy who acquired undergone platelet function research, genetic assessment, or appraisal of blood loss risk (29). They discovered that the chance of blood loss could be forecasted by determining low on-treatment platelet reactivity through a number of different platelet function lab tests, by spotting carriage from the CYP2C19*17 allele, and with a blood loss BIRB-796 inhibition score like the RISK-PCI BIRB-796 inhibition or ISTH/SSC types. Notably, generally in most ratings age group (either appraised as a continuing variable or being a discrete one when 70C75 years) demonstrated an essential component of blood loss ratings. Co-workers and Bellemain-Appaix pooled 7 randomized and non-randomized scientific studies including as much as 32,383 sufferers with non-ST-elevation severe coronary syndromes designated to pretreatment with dental P2Y12 inhibitors pooled 10 randomized medical trials comparing short-term (3C6 weeks) dual antiplatelet therapy carried out an umbrella review quite related in design to our present work, but different in terms of scope and focus Rabbit Polyclonal to Cyclin H (phospho-Thr315) (25). Specifically, they selected 16 systematic evaluations appraising the risk-benefit balance of long-term dual antiplatelet therapy after percutaneous coronary treatment, albeit including only 8 randomized tests. They concluded that prolonging dual antiplatelet therapy beyond 1 year may reduce the risk of myocardial infarction and stent thrombosis, but may increase the risk of death and major bleeding, especially in subjects at higher risk of bleeding. Lane and colleagues published in 2013 a detailed systematic review within the combination of oral anticoagulants and oral antiplatelet providers in individuals with atrial fibrillation and high-risk features (including therefore coronary artery disease), totaling 53 randomized and non-randomized studies and 187,502 individuals (27). They concluded that at that time there was no evidence in favor of combination therapy in such condition. However, subsequently dedicated trials have been published and should be taken into account (carried out a meta-analysis on 5 randomized medical tests including 6,239 individuals undergoing main percutaneous coronary treatment for ST-segment elevation myocardial infarction, who had been randomized to dual antiplatelet therapy plus proton pump inhibitors None of them. Notes The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). BIRB-796 inhibition Observe: https://creativecommons.org/licenses/by-nc-nd/4.0/. Footnotes This short article was commissioned from the Guest Editor (Ion S. Jovin) for the series Interventional Cardiology posted in All writers have finished the ICMJE homogeneous disclosure type (offered by http://dx.doi.org/10.21037/jtd.2019.12.87). The series Interventional Cardiology was commissioned with the editorial office.
This entry was posted in PTH Receptors on July 12, 2020 by Francis Hughes.


50 Things You're Not Supposed To Know Volume 2 is an interesting book, full of trivia that shapes our world. Russ Kick followed the first book in this series with another worthwhile tome filled with facts from "men have clitorises" to "God's name is 'jealous'." Every fact has a couple of supporting paragraphs, but I found especially useful the references listed at the back of the book. Every fact has its own bibliography, so I can research some of then more interesting claims made in depth on my own.
My next book is the collection of Angry Youth comics, What're You Lookin' At? by Johnny Ryan. Comics are a literary genre I've missed out on so far in my life, thanks to the folks at Atomic Books for picking this out for me and broadening my horizons.


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Drone-mapping slums for land titling — one pixel at a time
Anand Murali	Pankaj Mishra	May 28, 2018 10 min
K Venkatesh remembers vividly the November afternoon when he first saw the flying object swooping over his locality in the Nolia Sahi slum in coastal Odisha. A black, bird-like creature was flying across and making a buzzing sound, he says. Others living in the slum, near the Konark beach and one of Odisha's biggest with a few hundred households, were perplexed too.
Never did Venkatesh or his neighbours imagine that the drones flying over their settlement would be the answer to their decades-old problem of a permanent home. They are among some one million slum dwellers in Odisha, who like elsewhere in India live under the constant threat of eviction in the absence of land rights – no matter how long they have stayed in the hutment.
The drones were a key instrument in what is being billed as the world's largest slum titling project. Nolia Sahi was among the first few slums across the districts of Ganjam and Puri to carry out a drone-based survey before the slum dwellers could be handed land rights under the government's Odisha Land Rights to Slum Dwellers Act 2017.
The Act covers 109 municipalities in the state and ensures identified slum dwellers living in small towns rights over up to 600 sq ft of land while in the cities they will get rights over up to 450 sq ft. The Act and the programme comes ahead of the assembly elections in the state slated before summer of 2019.
Laws are made by politicians and wonks in the cities and implemented (read: anything but) in faraway lands, it is said. Likewise, the biggest challenge in the Odisha slum titling project was to verify the exact slum households in a given area and make land rights accordingly. Manual surveys and mapping would have taken nearly a decade. And the government wanted to hand over land titles by 2018.
Solution? The government turned to drones for ensuring both the speed and accuracy. Tata Trusts, along with officials from the state government and Omidyar Network, brought a fleet of over dozen drones to map around 250,000 slum households across the state, create fresh maps, and blend that data with on-the-ground surveys about families residing in the slums. More on the two partners of the government later.
Venkatesh's slum was among the 2,000 households who received their "patta" or land rights certificate from the government earlier this month. By December 2018, the government plans to allot land ownership certificates to nearly 200,000 slum households.
The 35-year-old fisherman says he understands now what the drone was doing up in the sky in November. "We actually didn't understand what freedom means even after India's independence in 1947. This (land title) means the real freedom for us," Venkatesh says in Telugu.
Nayak C, who lives in Mausima Sahi slum in Konark, wants to thank "the lifeless" drone for kicking off what he calls a revolution. "It's god sent for us. Nobody doubts the images captured by the drones," he says in Hindi. Nayak, 44 and handicraft shop owner, is also the president of his local slum association and helps coordinate with the government officials and the local community.
Mapping boundaries digitally
The Odisha slum titling effort is a smart governance project with lessons for the rest of the country. Some 65 million people live in slums in India, according to the 2011 national census, and the number was estimated to have risen to over 100 million by 2017. That's more than the population of Egypt.
Most slums in India are run under the patronage of local politicians and strongmen, for whom the overcrowded urban housing is an easy source of rentier profits. Over long periods, governments are forced to recognise the slum areas as legitimate settlements. But they are faced with considerable revenue leakages while collecting costs of delivery of public services such as water and electricity because data of the end user is not easily available. The process is messy dragging on and on.
G. Mathi Vathanan, the secretary of Odisha's housing and urban development department, didn't have the luxury of time. A manual mapping of the targeted 250,000 slum households across the state would have easily taken up to a decade, nothing less. Moreover, relying purely on manual surveys could have attracted allegations of favouritism and other wrongdoing.
"We took the ordinance route and not normal legislation route to ensure speed and minimise any misuse," says Vathanan. "Then, the question was how do you prove that you have been living up to that cut off date (August 10, 2017). Anybody can give an affidavit. We asked them to bring any government issued proof; it could be an Aadhaar card, letter from a government school, or anything else issued by the government."
"We then said that we have to fix the boundaries of slums digitally," says Vathanan, a 1994 Odisha cadre IAS officer who holds an M.Tech degree from the Indian Institute of Technology-Madras.
Drones not only assured speed and building blocks for the core data in digital format, but also the much needed transparency in executing a program of this scale and complexity. "Drone survey is the first activity. First, we capture the boundary, and then prepare the maps, and then you activate the slum survey," explains Vathanan. Manual surveys are subject to manipulations at the ground level, he adds.
The other challenge was to ensure that there aren't too many different government departments involved in the execution. "Manual (survey) is very time consuming. I do not have the machinery, I have to borrow the revenue (department's) machinery. I have to depend on another department's machinery. That department is meant for protecting the land, not for giving it away. By nature, they are an enforcement agency," adds the housing secretary.
G. Mathi Vathanan, the secretary of Odisha's housing and urban development department
Drones were just the starting point, however. The data collected needed to be vetted on the ground. "It's followed by the ground survey, door to door checks across slum households. It involves verifications from the community. We measure how much of space they actually occupy. We measure it with physical tapes," says Vathanan, adding having the drone pictures helps.
Once that is done, a list of occupants is drawn up so that everyone can verify it. "This takes out the slum landlords. At the slum level, a proposal is finalised and given to the municipality. A scrutiny committee goes through the proposal case by case, they even reverify everything, and make the final list inviting any potential objections," says Vathanan.
The digital data is then transferred to the GIS-based state map reflecting every detail. (GIS is short for geographical information system, which is used to store and manage geographical data.)
The partners: Tata Trusts, Omidyar Network
Vathanan and the Odisha government partnered with Tata Trusts and Omidyar Network, an impact investing firm, for implementation of the programme – right from drone mapping to allotment of the land rights.
Shishir Ranjan Dash, who is leading the slum titling work for Tata Trusts, says everyone kept chanting drones wherever he went. "They were all fascinated and used to ask me if I was carrying a drone myself," he recalls.
Of the 109 municipal areas to be covered, Ganjam and Puri were the first to be piloted because of good support from district authorities there, says Dash. "The first task was to mark the slum boundaries. We didn't know if a particular household was part of a slum or not. We used the Differential Global Positioning Systems surveys," he says.
A WhatsApp group helped with the coordination. "We had everyone from the district collectors to local officials on the group apart from the housing secretary. That helped because everytime we flagged a bottleneck, it was immediately addressed," Dash adds.
Pictures captured during each drone flight are processed as orthophotos, which are aerial photographs that have been geometrically corrected so that they have a uniform scale and can be used like regular maps. So far, about a dozen Phantom drones from the Chinese quadcopter maker DJI have been deployed. These drones cover about a kilometer during each flight lasting five to seven minutes.
Shishir Ranjan Dash, who is leading the slum titling work for Tata Trusts
Later, all the images are indexed with clearly demarcated boundaries. This helps in the on-the-ground part of the survey. Dash and his team of volunteers then visit each household and verify the number of family members and get other details.
The key is to combine drone data with on the ground reporting and verification. "After we record the details of each household in an Excel sheet, we ask the community members to identify those who are genuine slum dwellers," says Dash.
"In the first phase, we surveyed around 3,200 slum households, out of which nearly 2200 were given "patta" or land rights. Now, we are looking into why the remaining 1,000 or so have not been given the land rights,"says Dash.
Power of drones
Precision mapping using drone surveys also helps in identifying and creating space for creating a livable habitat, Dash says. Millimeter level mapping will help the administration carve out space for living amenities beyond just land.
"We want to create liveable habitats and not just slums. What are the requirements of the people residing in slums beyond basic services? For instance, if there's a pond nearby where slum dwellers are taking bath, we include that within the boundaries," says Dash. Other targets include each household having access to an ambulance and a toilet, he adds.
Omidyar leveraged its expertise in spatial technology and its work with the Asia Foundation on a drone-based land survey project in the Philippines.
"The Philippines government has specified very specific standards of surveying. We supported The Asia Foundation to demonstrate the potential of drones as a new alternative technology for surveying," says Shreya Deb, Principal, Investments at Omidyar Network.
A member of the mapping team along with the drone
The Philippines pilot was successful leading to drones-based surveying becoming a government approved method of such surveys in that country. Omidyar Network believes the drone technology is "a powerful epicenter for community involvement in mapping households".
The Odisha Space Applications Centre (ORSAC), a state agency, was roped in to set benchmarks for accuracy in the mapping surveys. The project team set up a test bed which underwent a detailed survey by ORSAC and the results derived were used as a benchmark to evaluate mapping vendors. Two were selected.
"The detailed survey by ORSAC set a very high accuracy test bed against which the mapping agencies were benchmarked. In future, the test bed can be used as a benchmark to test other vendors for their accuracy, speed and turnaround time," Deb told FactorDaily.
Drone-based surveys are becoming the new method of choice when it comes to surveying or mapping areas especially with the speed and accuracy that the technology offers. Earlier this year, the Slum Rehabilitation Authority of Mumbai conducted a drone-based survey pilot at Hariyali village in Kurla as part of a bigger plan to map slums across Mumbai. (The lead picture with this story is of a slum in Goregaon.)
According to Ananth Padmanabhan, a fellow at think tank Carnegie India, there is a lot of digitisation in land titling in India today but the data on the title can be wrong to begin with. This becomes all the more troublesome with new technologies like blockchain where data is immutable and inaccurate data can have a significant impact on the entire implementation. States such as Andhra Pradesh, Maharashtra, and Telangana are trialling land titles on blockchains, as is NITI Aayog, India's policy thinktank.
"Surveys and mapping done using drones provide better granular data, especially when it comes to highly populated settlements like slums where boundaries are difficult to be identified. Also, drones allow you to cover a larger area in the same amount of time with good accuracy," says Padmanabhan.
Imagery captured over time of the same area can be used to monitor development or progress in areas over a period of time.
Updated at 12:06 pm on May 28, 2018	To correct the name of Shishir Ranjan Dash of Tata Trust. His first name was earlier misspelt as Shirish.
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Put the water and butter into a double boiler and set on the range. Mix the sugar, flour, and corn starch together; grate in the lemon rind, add the juice and beaten yolks of the eggs. When the water in the boiler is scalding hot, stir in the mixture, and cook till of the consistency of cold honey, stirring now and then to ensure even cooking. Remove from the fire; when cool, pour into deep pie tins, lined with good pastry. When done, meringue with the whites of the eggs.
Butter, size of an egg.
Soak the cocoanut in the milk, add the beaten egg, sugar, and butter melted. Line a pie-pan with rich pastry, put in the filling, and bake. The white of one of the eggs may be used as a meringue, if desired.
Vanilla, 1 teaspoonful. Flour, 1 rounded cup. Sugar, 1 cup. Lemon juice, 2 teaspoonfuls.
Beat the yolks of the eggs till very thick; add the sugar, vanilla, and lemon juice. Beat the whites of the eggs very stiff, fold half the whites into the yolk and sugar, then half the flour, then the remainder of the whites and the rest of the flour. Divide this batter into two pie-pans and bake. When cold, split each cake and put in the filling.
Put three-fourths of the milk into a double boiler, together with the milk, and set on the range. Beat the eggs very light; add the sugar, flour, and the remainder of the milk. Beat till perfectly smooth, and when the milk in the boiler is scalding hot, stir in the mixture. Beat till smooth, and cook thoroughly; when cool, add the vanilla. If made a day or two before serving, and kept on ice, the quality of these pies is greatly improved.
Egg, 1. Lemon, 1. Sugar, ½ cup.
To the marmalade add the grated rind and juice of the lemon, sugar, and beaten yolk of egg; put into a pie-pan lined with good paste and bake till the crust is done; remove from oven and meringue with the white of the egg.
Line a pie-pan with rich paste, sprinkle over the bottom a little flour and sugar. Fill with apples cut in thin slices. The pan should be slightly rounding full. Sprinkle a little flour and sugar, according to the tartness of the fruit. Add two tablespoonfuls of water, and a few small pieces of butter. Moisten the edge of the paste and put on the upper crust, press down the edges, trim, make several perforations in the top to allow the steam to escape, brush the crust with a little milk, and bake about forty-five minutes.
Line a pie plate with paste rolled a little thicker than a dollar. Strip the skin off the rhubarb and cut the stalk into half-inch lengths. Fill the plate an inch deep, and to a quart of rhubarb add a large cup of sugar. Sprinkle a pinch of salt, and a grating of nutmeg on top, with a little flour. Cover with a rich crust and bake in a quick oven until the pie loosens from the dish.
Line a pie-pan with pie paste. Put in the berries half an inch deep, and to one quart of berries put a teacup of brown sugar; sift a teaspoonful of flour over, a pinch of salt, and a little grated nutmeg. Cover with the top crust, pressing down the edges tightly. Trim and bake in a good oven forty-five minutes. This pie is the typical berry pie.


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AAHA Home AAHA publications NEWStat Weekly News Roundup 4/27 – 5/4
Weekly News Roundup 4/27 – 5/4
NEWStat - 5/4/2017
New York bill would ban declawing cats
A proposed bill would ban the declawing of cats in the state of New York. Declawing is already illegal in Los Angeles and several other California cities, but if the bill became law, New York would be the first state to ban declawing. New York's Veterinary Medical Society opposes the bill, arguing that declawing must remain as a final option for owners who would otherwise surrender their cats to shelters, where many could be euthanized.
FDA cracks down on unproven cancer treatment claims
The Food and Drug Administration has sent warning letters to 14 companies, ordering them to stop making claims about the anti-cancer properties of their products. The products have not been approved by the FDA, and administration voiced concern that people would go to these products instead of seeking appropriate care. The companies have 15 days to correct violations or provide a plan to correct violations.
University of Arizona's veterinary school proposal rejected
The University of Arizona's proposed veterinary school has been put on hold until at least 2019. In 2016, the American Veterinary Medical Association's Council on Education ruled that the university's plan for a fast-track veterinary school was too flawed to pass. The university appealed the decision but lost the appeal. The council offered to accept a new application in June, but the process to approve that application could take 18 months or more.
Endangered red wolf pups born at Museum of Life and Science
A red wolf female at the Museum of Life and Science in Durham, North Carolina, gave birth to a litter of six pups last week. This is the first litter born at a facility since 2002. Red wolves are endangered, totaling about 300 in the wild and in captivity. They were declared extinct in the wild in 1980, and since then zoos, museums, and wildlife facilities have been attempting to bring red wolves' numbers back up and release some into the wild.
Photo credit: © iStock/carenas1


text:
Betriebsart steht für:

 Amateurfunkbetriebsart, Übertragungsarten im Amateurfunk
 Arbeitspunkteinstellung bei Verstärkern, siehe Endstufe
 Betrieb als juristisch unterschiedliche Klassen von Gewerbebetrieben
 Betriebsart (Waldbau), Waldbausysteme
 Betriebsarten von automatischen Werkzeugmaschinen
 Betriebsmodus (Kryptographie)
 Betriebsverfahren, Art und Weise der Betriebsführung auf einer Eisenbahnstrecke
 Modulationsart, Übertragungsarten in der Funktechnik
 Nennbetriebsart, Nennbetriebsarten von elektrischen Maschinen

Siehe auch:


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Jeremy D. Brown
John C. Malone Assistant Professor
Jeremy D. Brown, the John C. Malone Assistant Professor in the Department of Mechanical Engineering, explores the interface between humans and robotics, with a specific focus on medical applications and haptic feedback.
Brown's research sits at the intersection of engineering, biomechatronics, medicine, and psychophysics. He develops novel haptic interfaces for upper-limb prosthetics and minimally invasive surgical robotics. Applications of this research include giving amputees a sense of touch through their prostheses ,and helping surgeons use surgical robots to improve their accuracy and precision when performing delicate procedures.
Brown's team in his Haptics and Medical Robotics (HAMR) lab uses methods from human perception, motor control, neurophysiology, and biomechanics to study the human perception of touch, especially as it relates to applications of human-robot interaction and collaboration. Elements of HAMR's research could lead to breakthroughs in additional fields, including rehabilitation robotics.
In 2017, Brown received National Science Foundation funding for a project to develop better haptic interfaces by providing the robotic system with information regarding the physiological changes that occur in the human body when it is mechanically coupled to the robotic system. He is also the recipient of an NSF Graduate Research Fellowship, the Best Student Paper Award at the 2012 IEEE Haptics Symposium, and the Penn Postdoctoral Fellowship for Academic Diversity.
He is a member of the Institute of Electrical and Electronics Engineers' (IEEE) Robotics and Automation Society, American Society of Mechanical Engineers (ASME), and National Society of Black Engineers (NSBE). Brown's work has appeared in a number of peer-reviewed journals, including the Journal of Neuroengineering and Rehabilitation, IEEE Transactions on Haptics, IEEE Transactions on Biomedical Engineering, and IEEE Transactions on Neural Systems and Rehabilitation Engineering.
Brown is a graduate of the Atlanta University Center's Dual Degree Engineering Program, earning bachelor's degrees in Applied Physics and Mechanical Engineering from Morehouse College and the University of Michigan, respectively. He received his MSE and PhD in Mechanical Engineering at the University of Michigan, where he worked on haptic feedback for upper-extremity prosthetic devices. Prior to joining Johns Hopkins in 2017, he was a postdoctoral research fellow at the University of Pennsylvania.
Ph.D. 2014, Univ of Michigan Ann Arbor*
Master of Science in Engineering 2012, University of Michigan
Bachelor of Science in Engineering 2008, University of Michigan
Bachelor of Science 2008, Morehouse College


While surveys vary about just how much consumer spending will increase, it's shaping up to be a mother of a Mother's Day: The National Retail Federation predicts total spending to reach $21.2 billion, the highest in the 12 years it has tracked the holiday.
And this year, it's evident people intend to broaden their interpretation of the holiday more than ever. "More and more, Mother's Day encompasses a broader spectrum of relationships," says Robert Passikoff, founder and president of Brand Keys, in the report.
The Brand Keys research reports that consumers are leaning toward such traditional gifts as cards, meals (brunch or dinner), flowers, spa services, jewelry, and clothing.
The NRF survey, conducted by Prosper Insights & Analytics with more than 6,200 adults, found similar results. About 80% say they will buy Mom a greeting card, and 67% plan to buy flowers. And like Brand Keys, it's predicting a surge in maternal jewelry gifts, with 34% planning to buy Mom bling, up from 31% last year. That could amount to $4.3 billion in jewelry sales, also a record for the survey.
The NRF reports that online shoppers intend to spend more, about $252 on average.
IBISWorld also released its forecast, calling for a gain of about 3.8%, or $169.21 per family. It predicts the biggest gains will be in electronics, including smart phones and tablets, dining out, and jewelry.


In Bloggie or any other blog platform, the content is the meat of the platform. In order to make great content, the Editor plays a big role. Therefore, we have been paying a lot of attention to improving the Editor than other parts since the beginning.
We released the first prototype of our Editor a few months back, and we've been using it heavily ourselves, even for editing documents that are not intended to be posted in Bloggie. We figured out that this is the best way to truly understand the pain point and the experience of our Editor.
And it actually worked out pretty well!
Since then we have been fixing small bugs and enhancing the Editor incrementally. However, there are a few things that can only be fixed by a major revamp. A major revamp is hard to come by, but it finally happened last week!
Let's talk about the revamp in this post.
In older version of our Editor, the page height is very tall. The empty page itself is scrollable due to its tall height (refer to picture below).
This by itself is not an issue, the problem arises when the content becomes longer than one page. That time, we will have a double scrolling issue. See picture below.
The user experience quickly became annoying . When we want to scroll the content, we might easily and accidentally scroll the outer page.
We wonder how this issue is solved in other well-known sites.
Well-known sites usually have solid reasoning behind their UX. They have been through many iterations and perfected the experience for a long time after all.
So we tried to make sense of why it is done this way. After comparing to another few sites, we found out that the double scrolling in Github must have been intended.
In Github, while writing a comment, we often need to read the context from another comment. Hence the double scrolling.
In Bloggie's case, we are writing a single post, so we don't need double scrolling, so we moved on to check other sites.
In the case of Medium and Qiita, they have a clear solution to this issue. They both fixed their control panel at the top or bottom. The only scrollable area is the content area.
We noticed that there is an important feature to make an editor reliable ー the auto-saving feature. Without this, we might have lost hours of writing if we accidentally close the tab or if internet connection is lost.
Where to place the status?
To implement this, we need a place to show the status of the auto-saving. Otherwise, users wouldn't know that the post has been saved.
In the end, we shoved it into a blank space at the bottom.
This is not ideal because we will need to scroll to the bottom of the page to see it.
After the revamp, the status bar is fixed at the bottom, and will always be visible regardless of the scrolling position.
How frequent should we save?
Another question about auto-saving is how frequent should we save itnot ?
If we save it too frequently, it can be annoying. Typing a sentence might cause it to save 30 times easily.
If we did not save it frequent enough, a user might lose their content.
We have been using this for a while and we felt good about it. So we kept this rule.
By fixing the control bar at the bottom, the control elements are now all hidden at the beginning, and will only be revealed when we hit the publish button.
This way, the page looks much cleaner and we don't have to make any decisions about publishing (e.g. tagging, cover image) until we are about to publish. Asides from the page itself is cleaner, it also helps the users to stay focus at one thing at a time.
I hope you enjoy the post, and that's all for now, see you in the nextin post!
Android Programmer who likes writing blogs, reading, coffee, snowboarding.
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