text:
FAU Business Incubator Grows, Again
Boca Business FAU
March 27, 2013 bocanews48Leave a Comment on FAU Business Incubator Grows, Again
BOCA RATON, FL (BocaNewsNow.com) — As the economy turns around, businesses are finding it's a great time to grow, and many are relying on the resources and expertise of Florida Atlantic University to make it happen.
Ten months ago, the Research Park at Florida Atlantic University and Enterprise Development Corporation of South Florida expanded the Technology Business Incubator™ (TBI) by 5,000 sq. ft. in response to a growing demand. A second expansion will be complete this March, adding an additional 10,000 sq. ft. to accommodate a vast need for additional space for its current client companies and to house new companies that have been on a waiting list.
The TBI, a location and knowledge resource center for entrepreneurs emerging from Florida Atlantic University – students, recent graduates and faculty – as well as regional entrepreneurs is currently home to 23 early stage high-tech companies as well as the New World Angels and the Institute for Commercialization of Public Research. The most recent expansion brings the TBI to a total of 25,000 sq. ft. and will accommodate an additional 15 companies, with individual offices ranging from 120 to 1,000 sq. ft.
"The TBI is an exceptional facility which has attracted entrepreneurial attention to our brand of specialized assistance available to startup technology companies," said Andrew Duffell, president and CEO of the Research Park at Florida Atlantic University. "Resident companies collaborate and find the resources they require to make their business a success. Whether in need of mentors, investors, community collaborators, and business services such as human resources or accounting, everything is under one roof and in close proximity to FAU research and faculty."
The expansion will also feature a 4,000 sq. ft. co-working center operated by Caffeine Spaces. The co-working environment will incorporate independent entrepreneurs, programmers and service providers for the startups to bond with and draw talent from, adding to the entrepreneurial culture. Under one roof, TBI companies tap into an array of resources including mentors, other entrepreneurs, community collaborators, and business services, creating an environment that provides what companies need in order to be successful.
"We've seen an overwhelming need to further expand our facilities to make room for additional companies," said Rob Strandberg, president and CEO, Enterprise Development Corporation. "In June 2012, we were at 100% occupancy and started a waiting list, allowing non-tenants to use our facilities in order to accommodate their needs as much as possible; often using our conference rooms, shared offices and even setting up shop in our break room."
The new and larger space features a Student Innovation and Invention Lab designed for use by FAU student-based teams working on industry projects. Also included is a dedicated office for the annual FAU Business Plan Competition winner. A kitchen and lounge area encourage casual and spontaneous interaction among residents and other Research Park tenants and FAU faculty.
For the emerging company requiring advanced broadband capabilities, the space is wired with Gigabit Ethernet cabling and optic fiber, and includes a server room with back-up battery power and a generator available to host resident company servers.
About the Research Park at Florida Atlantic University
Established in 1985, the 94-acre Research Park (www.research-park.org) is home to
23 technology companies working in conjunction with the FAU College of Engineering and Computer Science, the FAU Charles E. Schmidt College of Medicine and the FAU College of Business. TheResearch Park also hosts the Technology Business Incubator™ with 23 startup technology companies, each of which receives business and consulting services with the goal of becoming established businesses and permanent residents in the Research Park.
HDG Mansur (hdgmansur.com) is the development partner for the Research Park, with leasing provided by Avison Young (avisonyoung.com)
B'Nai Israel Welcoms B'Nai Big Band Beat Friday Night
Boca Dentist, Richard Lipman, Arrested For Practicing Without License


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text:
Q: Can I use C language to program a CPLD/FPGA? I wanted to know if I can program  CPLDs /FPGAs using C language? If so, is it commonly practiced? What are the steps and the required & tools for the same?

A: Generally you can. There is free SystemC for HLS(High Level Synthesis). HLS is getting more and more popular but what you have to remember is that you do not program CPLDs /FPGAs using C language, you rather describe hardware using C language. To make it work on real hardware you need vendor specific HLS tools.
In my opinion, writing synthesizable description in C is harder than in Verilog/VHDL but it is usually faster if you are familiar with the syntax and you follow some extra rules.

A: For FPGAs, yes. I don't think there are many tools to target CPLDs with C (although in theory it should be perfectly possible).
I may be talking heresy here, but (to me) the advantage of C-to-gates is that you can run an awful lot of your algorithm development and verification in pure-C (using your normal C development environment, and well understood software tooling/debuggers...) and once it is working to your satisfaction, target it to the FPGA.
Then you only have to validate the C-to-gates transformation (ie the tool) in simulation and hardware.  If you write your algorithm in HDL, you have to verify the algorithm in very slow simulation, and then verify and validate your implementation in hardware (and/or even slower gate-level simulation).
You may have to iterate for performance (but you probably had to do that post-synthesis anyway even in HDL, unless you were very good at HDL optimisation... and I contend that after a few months you can be very good at C-for-gates optimisation and then not iterate as much either)

A: There are two main ways to do this: one is with HLS where you write a description of a high level algorithm in c and it gets translated to HDL or a netlist. HLS is not really applicable for a complete design though, usually just a few pieces. The other way is to put a soft CPU on the FPGA, and then program that in C. Some FPGAs also contain hard CPU cores (Zynq has ARM cores, various Virtex chips have PowerPC cores) and those can certainly be programmed in C.

redpajama_set_name: RedPajamaStackExchange


Creating a cohesive program that moves from experimentation to straight-ahead swing and lush inventions – often on the same track – pianist Kris Davis outlines a series of moods on this program of her own compositions. Calgary-born Davis has made a reputation for herself as an arranger as well as a soloist and each of her compositions displays her sidefolk – some of New York's most accomplished players – to their collective best advantage.
Take for instance Pass the Magic Hat, which starts off as a swirling and spiraling exposition for her piano plus the bass of Trevor Dunn and the drums of Tom Rainey, but soon evolves to a contrapuntal duel between her metronomic comping and Ingrid Laubrock's pulsating tenor saxophone. A spikier secondary theme developed by violist Mat Maneri arrives, eventually to be harmonized with piano and reed slurs. On the other hand, Bottom of the Well is a cohesive recital-styled track with low-pitched piano clunks underscoring the chromatic string sets. Before a legato finale, Dunn vibrates a solo in the cello-range while the violist harshly rubs his strings. With Davis' narrative literally more low-key and impressionistic, Pi is Irrational balances Maneri's tremolo stridency with Rainey's rugged ruffs and taps, until Laubrock's gentling arpeggios presage a brief, rhythmically sophisticated bass solo.
Davis who studied at Banff and Toronto defines her program enough to give her soloists the freedom to interpolate everything from strident reed bites and fiddle scratches to extended cymbal vibrations into the nine tracks. But she reins them in enough with strategies ranging from inner piano string plucks to keyboard jabs and cohesive chording to maintain the integrity of her compositional visions.


There isn't a man among us who could call themselves perfect, and for those who are caught by law enforcement exercising one of man's many imperfections, there are lawyers in Texas who will represent them. The Law Offices of Tad Nelson and Associates headed up by Houston Criminal Law Guru Tad Nelson is one of the criminal lawyers I would recommend to anyone arrested in the Houston area. Once you see this video, you'll know why I say talking with Tad Nelson is always best if you or someone you know is in trouble with the law and are seeking legal assistance.
Houston criminal defense lawyer Tad Nelson is a board certified criminal law specialist as declared by the Texas Board of Legal Specialization (also known as the TBLS). There are a number of lawyers in Houston taking the lives of people into their hands by way of serving as their legal counsel, but few lawyers are qualified to level of attorney Tad Nelson. He handles all types of felony and misdemeanor criminal offenses as well as federal charges and white collar criminal offenses. He also has a wealth of experience representing men and women accused of criminal offenses than can be deemed as "sexual in nature".


text:
.class final Lmeizu/samba/client/RemoteSharedFolder$1;
.super Ljava/lang/Object;
.source "RemoteSharedFolder.java"

# interfaces
.implements Landroid/os/Parcelable$Creator;

# annotations
.annotation system Ldalvik/annotation/EnclosingClass;
    value = Lmeizu/samba/client/RemoteSharedFolder;
.end annotation

.annotation system Ldalvik/annotation/InnerClass;
    accessFlags = 0x8
    name = null
.end annotation

.annotation system Ldalvik/annotation/Signature;
    value = {
        "Ljava/lang/Object;",
        "Landroid/os/Parcelable$Creator",
        "<",
        "Lmeizu/samba/client/RemoteSharedFolder;",
        ">;"
    }
.end annotation

# direct methods
.method constructor <init>()V
    .locals 0

    .prologue
    .line 77
    invoke-direct {p0}, Ljava/lang/Object;-><init>()V

    return-void
.end method

# virtual methods
.method public bridge synthetic createFromParcel(Landroid/os/Parcel;)Ljava/lang/Object;
    .locals 1
    .param p1, "x0"    # Landroid/os/Parcel;

    .prologue
    .line 77
    invoke-virtual {p0, p1}, Lmeizu/samba/client/RemoteSharedFolder$1;->createFromParcel(Landroid/os/Parcel;)Lmeizu/samba/client/RemoteSharedFolder;

    move-result-object v0

    return-object v0
.end method

.method public createFromParcel(Landroid/os/Parcel;)Lmeizu/samba/client/RemoteSharedFolder;
    .locals 5
    .param p1, "in"    # Landroid/os/Parcel;

    .prologue
    .line 79
    new-instance v0, Lmeizu/samba/client/RemoteSharedFolder;

    invoke-virtual {p1}, Landroid/os/Parcel;->readString()Ljava/lang/String;

    move-result-object v1

    invoke-virtual {p1}, Landroid/os/Parcel;->readString()Ljava/lang/String;

    move-result-object v2

    invoke-virtual {p1}, Landroid/os/Parcel;->readString()Ljava/lang/String;

    move-result-object v3

    invoke-virtual {p1}, Landroid/os/Parcel;->readString()Ljava/lang/String;

    move-result-object v4

    invoke-direct {v0, v1, v2, v3, v4}, Lmeizu/samba/client/RemoteSharedFolder;-><init>(Ljava/lang/String;Ljava/lang/String;Ljava/lang/String;Ljava/lang/String;)V

    return-object v0
.end method

.method public bridge synthetic newArray(I)[Ljava/lang/Object;
    .locals 1
    .param p1, "x0"    # I

    .prologue
    .line 77
    invoke-virtual {p0, p1}, Lmeizu/samba/client/RemoteSharedFolder$1;->newArray(I)[Lmeizu/samba/client/RemoteSharedFolder;

    move-result-object v0

    return-object v0
.end method

.method public newArray(I)[Lmeizu/samba/client/RemoteSharedFolder;
    .locals 1
    .param p1, "size"    # I

    .prologue
    .line 88
    new-array v0, p1, [Lmeizu/samba/client/RemoteSharedFolder;

    return-object v0
.end method

redpajama_set_name: RedPajamaGithub


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In June 2017, queer artist and activist Andy Simmons completed the first of twelve color illustrations exploring the imagistic history of the Hanky Code, a sartorially driven, discreet coding system used by queer men to express sexual desire.
In the decade bookended by the Stonewall riots and the advent of HIV/AIDS, urban queer male culture experienced rhizomatic transformation. The heady rush of political praxis immediately following 1969 left its intoxicating watermark on the economies of pleasure and desire queer men nourished from San Francisco to New York City.
It would be misleading, of course, to suggest that the first legible crystallization of urban queer male culture materialized in the 1970s. The vibrant cultural ecologies of the post-Stonewall moment were shaped by the multiplicity of queer male social and sexual histories, the coalescence of which sometimes resulted in the adoption of nuanced methods of sexual communication—like the hanky code, known also as the handkerchief code, the banana code, or flagging.
The 1970s hanky code, as described by American sociologist and historian Cindy Patton, generated meaning through the "semiotic use of bandanas of different colors," the selection of which expressed interest particular modes of sexual practice. In terms of practice, an individual would place a handkerchief in one of his back pockets; when read alongside the handkerchief's colors and patterning, the placement of the handkerchief in either the right or left pocket revealed the wearer's sexual interests. The conceptual yoking of the handkerchief to sexual expression transformed the sartorial medium into a sexual text—exclamatory to those already versed in its coding schema, inconspicuous to those unaware of its signifying labor.
Despite the hanky code's novelty and likely importance within spaces inimical to queer sexual expression, its emphasized substitution of articulated sexual particularity for more universal and universalizing signifiers necessarily flattens the nuanced economies of desire out of which the code arose. This hollowing of sexual difference, inadvertently effected by the creation of a system meant to augment sexual possibility, underscores the shifting potentials immanent to a critical concept of the medium.
The gay semiotic is far more sophisticated than straight sign language, because in gay culture, roles are not as clearly defined. . . . Gays have many more sexual possibilities than straight people and therefore need a more intricate communication system.
In the gay semiotic the body is divided into sides, the left representing the aggressive, the right the passive. Any sign placed on the left side indicates that the wearer will always take an active role during sexual activity. Conversely, a sign on the right side of the body indicates passive behavior.
Of interest here, in addition to Fischer's situating queer sexual possibility as both a repository of difference and a chamber of sameness, is the reversal of the binaristic associations between passive/aggressive and left/right. Although Fischer's subsequent capitulation that handkerchiefs may ultimately be "ambivalent signifiers because many individuals prefer to pick their roles after they pick their partners" only results in further equivocation, I would like to contend that the slippage visible within Fischer's analysis illuminates an important aspect of the handkerchief as a medium and the hanky code as a mediated system of sexual communication.
My purpose in mentioning the specifics of Fisher's analysis is not to critically glorify the presence of inconsistencies but rather to marshal those inconsistencies as evidence of the signifying medium's inevitable potential for contradiction, confusion, and communicative failure.
In the version of the hanky code considered authoritative (likely because it is an aggressively distilled taxonomy and thus one more easily employed), the color-categories available for selection simultaneously seem to include so much as to bleed into one another and to remain so disparate as to confound any suggestion that the "hanky code" was used by any homogenized sexual culture (i.e., queer men). Because the handkerchief communicates not only an interest in certain sexual practices but also the "role" one prefers in the realization of those sexual practices, it is difficult to determine whether it was realistically possible to adhere to the code's demarcations.
I would provisionally suggest that the emancipatory potential of the hanky code—its covert communication of vilified sexual desire—is limited by and also serves as a limit point of the capacity of any medium qua signifier to flatten difference. Placing a handkerchief in one's back pocket as an urban queer male living in the 1970s revealed to potential partners the possibility of sexual pleasure in myriad forms; however, in its display and dissemination of this information, the handkerchief ossified queer male libidinal economies by sedimenting reductive binaries onto queer male sexualities. Insofar as the "information" expressed by the handkerchief dealt in heteronormative sexual scripts, the hanky code mobilized a medium that broadened the discursive reach of male queerness without unmooring the heterosexualization to which non-normative sexualities are relentlessly exposed.
This entry was posted in Uncategorized by jlawless329. Bookmark the permalink.
Like Liz Losh, I really appreciated your sources as well as your comments on Fischer's ideas. In reading your post, I couldn't help but think of Erving Goffman's The Presentation of Everyday Life. To me, the hanky code presents a certain performance, (i.e. passive and active gender roles) insofar that the hankies are signs. I wonder how performance studies might work alongside your argument.
I enjoyed reading your thoughts on how the hanky code has the potential to be liberatory but nevertheless reinforces sexual binaries. I wonder how the hanky code itself is disseminated in contemporary gay spaces. Do infographics like the ones you feature in your post remain the dominant tool used to explain the hanky code or is the code widely recognized to the point that one could pick up on the meanings from social settings? Could disparities in the infographics be the first step in challenging the sexual binaries set up by the authoritative color code?
Using Patton and Fischer, you do a good job situating yourself among other critics who analyze the hanky code as an object of study. I thought your observations about the potential inconsistencies in Fischer's argument were particularly astute in characterizing the code as both liberatory in its polymorphous possibilities while also reinstating gendered binaries about active and passive roles. Given our discussions of signal theory, encoding, and decoding, I might have liked to have heard more about the "contradiction, confusion, and communicative failure" likely to occur in these discursive exchanges. If you are interested in doing more on this topic, apparently Martin Levine writes about it in Gay Macho (NYU Press, 1998).


Step 1: Read the text!! • Read the text several times: – First time read quickly to get a gist of what the text is about. – Then read more slowly, looking for the main... Techniques for Creating a Summary. The following are some techniques that can be applied to create your summary: Selection: this is the process of working through the original text to identify the key points that are raised within it.
A summary is a long text distilled to its essentials, the key points worth noting, without examples and details. The specific form, the sentence structure and the …... Automatic summarization is the process of shortening a text document with software, in order to create a summary with the major points of the original document. Technologies that can make a coherent summary take into account variables such as length, writing style and syntax .
Steps to Writing a Summary 1. Read and understand the prompt or writing directions. What are you being asked to write about? Read, think about, and understand the text. Review the material to make sure you know it well. Use a dictionary or context clues to figure out the meaning of any important words that you don't know. 3. Take notes. Write down the main ideas and important details of... A summary begins with an introductory sentence that states the text's title, author and main point of the text as you see it. A summary is written in your own words. A summary contains only the ideas of the original text.
Return to the text to locate specific evidence and passages related to the major ideas. Use your knowledge following the principles of analyzing a passage described below: test, essay, research, presentation, discussion, enjoyment.
How can I create two levels of detail, summary level and full text level, from the same Word or PDF document? I would like to create one file that is very detailed. Then create a short summary, maybe with a couple of clicks of the same Word or PDF document.
Automatic summarization is the process of shortening a text document with software, in order to create a summary with the major points of the original document. Technologies that can make a coherent summary take into account variables such as length, writing style and syntax .


PSR-16 (a PHP-FIG standard) is a second PHP-FIG cache standard. It's a driver model just like KeyValueStore, and it works very much in the same way.
It doesn't let you do too many operations. If get, set, delete (and their *multi counterparts) and delete is all you need, you're probably better off using this (or psr/cache) as this interface is also supported by other cache libraries.
This interface bridges the gap between KeyValueStore based adapters & features, and PSR-16: any of the Scrapbook tools are accessible in a PSR-16 compatible manner.
Fetch a value from the cache.
Persist data in the cache, uniquely referenced by a key with an optional expiration TTL time.
Delete an item from the cache by its unique key.
Wipe clean the entire cache's keys.
Obtain multiple cache items by their unique keys.
Persisting a set of key => value pairs in the cache, with an optional TTL.
Delete multiple cache items in a single operation.
Identify if an item is in the cache.
psr/simple-cache is a PHP-FIG (Framework Interop Group) standard for a driver model cache implementation. It's a relatively simple & straightforward driver model interface, very similar to KeyValueStore.


text:
Editorial Views| November 2019
Dexmedetomidine and the Upper Airway: Not as Simple as We Hoped
Denham S. Ward, M.D., Ph.D.;
Denham S. Ward, M.D., Ph.D.
From the University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, Rochester, New York (D.S.W., S.B.K.); Maine Medical Center, Portland, Maine (D.S.W.); and Tufts University School of Medicine, Boston, Massachusetts (D.S.W.).
Address correspondence to Dr. Ward: Denham_Ward@URMC.Rochester.edu
Suzanne B. Karan, M.D.
This editorial accompanies the article on p. 962.
Accepted for publication August 6, 2019.
Anesthesiology November 2019, Vol. 131, 953–954.
Commentary: Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study
Denham S. Ward, Suzanne B. Karan; Dexmedetomidine and the Upper Airway: Not as Simple as We Hoped. Anesthesiology 2019; 131:953–954 doi: https://doi.org/10.1097/ALN.0000000000002965
dexmedetomidine, upper respiratory tract
"Breathing is truly a strange phenomenon of life, caught between the conscious and the unconscious, and peculiarly sensitive to both"1
"[D]exmedetomidine seems to cause no less propensity for airway obstruction than does propofol at a similar level of sedation."
Image: S. M. Jarret, M.F.A., C.M.I.
With the epidemic of obstructive sleep apnea syndrome, concern about airway obstruction during sedation has increased. Dexmedetomidine, used for sedation in the intensive care unit and during procedures, has been thought to have fewer respiratory depressive effects than other sedatives, although airway obstructions and apneas with dexmedetomidine have been noted in several studies.2,3 This issue of Anesthesiology features work by Lodenius et al.,4 who found that dexmedetomidine is not superior to propofol in the propensity for causing airway obstruction at comparable sedation levels.
Sedative agents depress ventilation through a variety of actions including direct actions on upper airway muscle tone,5 on chemosensory pathways, and by removal of the "wakefulness" drive.6 Loss of the wakefulness input can unmask a profound depression of the chemosensory drive from sedatives and analgesics7 and reduce the drive to the pharyngeal dilator muscles. Respiratory physiologists routinely discriminate new sedative and opioid agents by their effects on the depression of the hypoxic and hypercapnic chemosensitivity.8 Moderate depression of the chemoreflexes is well tolerated, particularly when supplemental oxygen is supplied. However, even with supplemental oxygen, upper airway obstruction may result in serious hypoxemia in a matter of minutes. In sleep apnea research, the collapsibility of the upper airway during sleep has been quantified by the estimation of the pharyngeal pressure that is required to close the airway or keep it open.9,10 This methodology is being used to assess the propensity of medications to increase airway collapsibility.
The subjects in this study had a wider range of age (23 to 66 yr), body mass index (20.3 to 32.4 kg/m2), Mallampati score (1 to 4), neck circumference (31 to 45 cm), and risk for sleep disordered breathing (as indicated by the STOP–BANG questionnaire and apnea hypopnea values) than is usually found in a tightly controlled laboratory study. The subjects were also extensively instrumented, which included an esophageal pressure catheter, Bispectral Index, and three-lead electroencephalogram in addition to the usual laboratory respiratory physiology monitors. The sedation level was assessed by three well established methods. There are two important outcomes from this well designed and executed complex study. The first is that dexmedetomidine seems to cause no less propensity for airway obstruction than does propofol at a similar level of sedation. Interestingly, the three measures of sedation depth did not all show the same dose–response relationship even though the chemoreflex depression as measured by the increase in transcutaneous carbon dioxide (a measure of tissue partial pressure of carbon dioxide that is slightly higher than Paco2) showed similar increases for both drugs.
Second, and equally interesting, is the wide variation in the primary outcome of pharyngeal critical pressure. There were several subjects whose airways were resistant to collapse, requiring a subatmospheric pressure to collapse the airway, for both drugs. There are not enough subjects in this study to determine whether there were correlations with any of the subject characteristics. This underscores the need for more studies focused on patient characteristics that may predict airway collapsibility during sedation.
The precise relationship between airway collapsibility measured in a supine subject whose mouth is taped closed and the routine clinical situation during painful stimulation is not clear. This study was done in human subjects who were not exposed to painful stimulation, although dexmedetomidine provides analgesia and propofol does not. In clinical situations that require analgesia as well as sedation, the analgesic effect of dexmedetomidine may allow for lighter sedation than with propofol and thus less adverse ventilatory effects.
Nonetheless, to the extent that this laboratory study can be extrapolated to routine clinical situations, it does not appear that light to moderate sedation with dexmedetomidine offers any protection from central ventilatory apneas and airway obstructions over the commonly used sedative, propofol.
Supported by a U01 U.S. Food and Drug Administration public private partnership (to Dr. Ward) and by funding from the Department of Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York (to Drs. Ward and Karan).
The authors are not supported by, nor maintain any financial interest in, any commercial activity that may be associated with the topic of this article.
Jr: .
The Lewis A. Conner memorial lecture, the nature of cardiac and of pulmonary dyspnea.
: .
Effects of intravenous dexmedetomidine in humans: I. Sedation, ventilation, and metabolic rate.
Lodenius
Ebberyd
Hårdemark Cedborg
Mkrtchian
Christensson
Ullman
Scheinin
Eriksson
Jonsson Fagerlund
Sedation with dexmedetomidine or propofol impairs hypoxic control of breathing in healthy male volunteers: A nonblinded, randomized crossover study.
Lawther
Fagerlund
Upper airway collapsibility during dexmedetomidine and propofol sedation in healthy volunteers: A nonblinded randomized crossover study.
2019; 131:962–73
The upper airway during anaesthesia.
Br J Anaesth
Influence of cerebral activity in wakefulness on regulation of breathing.
J Appl Physiol
The effect of sleep plus morphine on the respiratory response to carbon dioxide.
Measurement of drug effects on ventilatory control
Pharmacology and Pathophysiology of the Control of Breathing
. Edited by
Dahan
Teppema
, pp
Permutt
Upper airway pressure–flow relationships in obstructive sleep apnea.
J Appl Physiol (1985)
Litman
Use of dynamic negative airway pressure (DNAP) to assess sedative-induced upper airway obstruction.
Copyright © 2019, the American Society of Anesthesiologists, Inc. All Rights Reserved.
Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study
Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial
Safe Sedation Re-examined: Comparing the Respiratory Effects of Dexmedetomidine and Propofol
Population Pharmacokinetics of Intranasal Dexmedetomidine in Infants and Young Children

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Java filename expansion library I'm looking for a Java library that helps resolve file paths, for example a library that would do something like:
String abs = Files.expand("$HOME/.bashrc")

or
String abs = Files.expand("~/$OTHER_DIR/../file")

and resolve those to a file path. Does any such thing exist?
Thanks!

A: Use the getEnv. Example:
String variable = System.getenv("WINDIR");
System.out.println(variable);

To discover them all, use:
Map<String, String> variables = System.getenv();

for (Map.Entry<String, String> entry : variables.entrySet())
{
   String name = entry.getKey();
   String value = entry.getValue();
   System.out.println(name + "=" + value);
}

Complete article in http://blog.codebeach.com/2008/02/get-environment-variables-in-java.html

A: That will be a platform dependent solution. (%var% in windows, $var in unix etc). Could you just use system properties?


text:
Nuclear Option
CNN's Stephen Miller incident proves how fake news ignorantly smears conservatives
White House adviser does not play mental footsie with fools
Entertainment_Culture
White House adviser Stephen Miller appears on CNN anchor Jake Tapper Sunday show. After an exchange, Mr. Tapper cut off Mr. Miller's mic, saying, "I think I've wasted enough of my viewers' time." (CNN.com) more >
By Charles Hurt - The Washington Times - Thursday, January 11, 2018
Behold, the anatomy of a "fake news" smear.
The latest drive-by character assassination of White House adviser Stephen Miller began, as it so often does, in a fact-free live TV orgy of public posturing by a journalist eager to display his virgin-snow virtue when it comes to unalloyed hatred of President Donald Trump.
This time it was CNN anchor Jake (Mr. Trump calls him "Fake") Tapper, who invited Mr. Miller on his Sunday show to respond to Mr. Tapper's complex conspiracy theory about how the president is somehow unfit or too mentally unstable to occupy the White House.
Obviously, Fake Tapper missed the report on Twitter that actually Mr. Trump is a "very stable genius."
Anyhoo, Mr. Miller had no intention of playing any of Fake Tapper's reindeer games. Instead, he wanted to talk about the unrelenting unfairness of CNN and its coverage of Mr. Trump.
When Mr. Miller refused to engage in Mr. Tapper's conspiracy fantasy, the anchor changed his mind and decided he no longer wanted Mr. Miller on his show.
"I think I've wasted enough of my viewer's time," he petulantly whined before cutting off Mr. Miller's mic.
It was a small, sad, silly moment in the death gurgles of American journalism. But enough to whip up a little buzz on Twitter or some Internet echo chamber. Which is all Fake Tapper was going for in the first place.
In all the frenzy, doddering old House Minority Leader Nancy Pelosi clamored over to the bright lights to declare through her unglued dentures that Mr. Miller — a Jew — is somehow a "white supremacist."
And then she declared that the Jew be fired from the White House. How that does not make Nancy Pelosi — a Christian, despite her infatuation with abortion — an anti-Semite?
Details. Minor details.
Then, along comes a Washington reporter who announces that Mr. Miller is "standing in the way of an immigration deal."
Not clear if this "deal" is a good one or a bad one. Mr. Miller is just standing in the way of it, which further proves he is a white supremacist.
Her entire story was entirely based on unnamed "sources," according to the reporter. Another death gurgle of American journalism.
The story includes a link to a "very tense and loud exchange" Mr. Miller had last year with another CNN reporter in which Mr. Miller utterly eviscerated the reporter over his near total ignorance of immigration policy in America.
All that matters to doltish reporters around here, though, is that the exchange was "very tense and loud." Mr. Miller is not only a (Jewish) white supremacist, he is an angry (Jewish) white supremacist. So, like Hitler, basically. Only Jewish.
It is true that Mr. Miller can come off as serious. After all he is a very serious guy. He does not play mental footsie with fools. The guy has studied U.S. immigration more deeply than just about the entire Washington press corps combined. He knows more about immigration than any of them.
Mr. Miller is not going to get into intellectual soft-pillow fights with reporters and lawmakers wearing their silly, soft and fuzzy pajamas.
Rather, Mr. Miller — and his boss — wants desperately to fix a horribly broken immigration system that created this whole unfortunate class of illegal Dreamers in the first place and prevent a future generation of "Dreamers."
If you have any doubt about the challenge Mr. Miller and Mr. Trump face in honestly addressing illegal immigration in this country, consider this: During this week's bipartisan meeting in the White House to begin negotiations, the word "DACA" was uttered 61 times. The universal sentiment among lawmakers from both parties was to pass some kind of "DACA" legislation that would legalize the illegal-immigrant Dreamers.
Sixty-one times.
The word "American" was used just 20 times. "Worker" only twice. "Citizen" not once.
"Citizenship" was used three times — as in the DACA bill should give Dreamers "citizenship."
The words "miner," "unemployed," and "lawful" were never uttered during the 55-minute confab.
Perhaps Mr. Miller is "standing in the way of an immigration deal" with these people. But is that a bad thing?
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PGI's extensive experience in small animal ultrasound extends back to its very first commercial offerings of ultrasound to the veterinary market in the late 1970's.
From that initial start, PGI's engineers and technicians have worked closely with all major Veterinary Schools in North America (Auburn University College of Veterinary Medicine, Colorado State University College of Veterinary Medicine, Cornell University College of Veterinary Medicine, to name a few), as well as numerous International Veterinary Schools and Institutions to develop small animal ultrasound equipment and techniques for the advancement of ultrasound technology in small animals.
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Following my retirement, I had just started to get my iQ personalized the way I wanted... the paint clayed and waxed nicely, some Motegi wheels and Cooper tires, the sub wired with some quick disconnects for easy removal, and the front plate moved to the tow hook location. Next on the agenda was some CF vinyl and the exhaust.
lets hope they'll replace it.
Are you in a Storm area?
Or this was just a freak, with no storm warnings?
Just wondering if this was in the Mid-West or East Coast?
Southern Illinois on Saturday night... under a severe thunderstorm warning... no sirens from EMS... reported the next day as straight line winds.
Inspected by a State Farm Select body shop today... estimate not appearing on my claim yet... but got a call from STF stating that my comp is $0 deductible, and rental is available anytime I am ready.
Scion tc2 rear tow hook?
Anyone with 15" wheels with 205/50/15 tires?


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HomeLivingHow Does Parkinson's Disease Affect The Mitochondria
How Does Parkinson's Disease Affect The Mitochondria
Mitochondria And Calcium Homeostasis
What mitochondria means for Parkinson's research
Other studies further support a role for alterations in mitochondrial Ca2+ homeostasis in PD. For instance, cybrid cells containing mtDNA from PD patients exhibit lower mitochondrial Ca2+ sequestration than control cells following carbachol-stimulated Ca2+ entry . Similarly, parkinsonian neurotoxins MPP+ and rotenone cause diminished mitochondrial Ca2+ uptake and increased cytosolic free Ca2+ in cultured cells . Also, exogenously applied oligomeric, but not monomeric, -synuclein to cultured dopaminergic neurons was shown to increase intracellular Ca2+ levels through a pore-mediated influx of extracellular Ca2+, leading to increased mitochondrial Ca2+-buffering burden and apoptotic cell death . Furthermore, PD-related protein PINK1 appears to regulate the physiological release of Ca2+ from the mitochondria via the mitochondrial Na+/Ca2+ exchanger . Indeed, ablation of PINK1 in dopaminergic neurons leads to impaired Ca2+ efflux from mitochondria, accumulation of mitochondrial Ca2+, increased production of mitochondrial ROS, decreased mitochondrial respiration, reduced , and a lowered threshold for Ca2+-dependent opening of the mitochondrial permeability transition pore complex, overall resulting in increased apoptosis . Supporting a role for increased Ca2+ load in PD-related cell death in vivo, pharmacological or genetic inhibition of Ca2+-sensitive proteases has been shown to attenuate dopaminergic neurodegeneration in MPTP-intoxicated mice .
The Molecular Basis For An
In contrast to its intrinsically disordered state in solution, -Syn adopts a highly helical conformation when associated with lipids . When any of the three exons encoding its N-terminal domain are deleted, the interaction between -Syn and vesicles is disrupted . These deletions also reduce the presynaptic localization of -Syn, suggesting that its reduced association with vesicles also impairs its transport along axons . Further proof that the N-terminus of -Syn associates with membranes comes from the protection of its residues 1 to 103 from proteolytic cleavage when -Syn is incubated with sodium dodecyl sulfate micelles or with lipid vesicles .
In in vitro studies, the binding of -Syn to large unilamellar vesicles correlates with the concentration of the non-bilayer-forming lipid cardiolipin , a type of lipid enriched in mitochondrial membranes . Another study has shown that the binding of -Syn to intact mitochondria can be reduced using nonyl acridine orange , and that stripping external proteins from mitochondria has no effect on the association between -Syn and mitochondria . This suggests that this association is not protein dependent . The protonation of -Syn under acidic intracellular pH also increases its binding to mitochondrial membranes, and this effect can be explained by the high content of acidic phospholipids in mitochondria .
Are Alterations In The Axonal And Synaptic Mitochondrial Populations Correlated With Respiratory Deficiency In The Soma
Although in human tissue it is not possible to compare cell body changes to synaptic/axonal changes within the same neuron, a measure of respiratory chain deficiency was made within the soma of SN neurons for most of the cases included in this study . Intensity measurements were made for immunoreactivity for NDUFB8, COXI and porin within TH positive cell bodies within the SN. A reduction in expression of either of these proteins was defined as an intensity value that had a z score of less than 1, normal neurons had a score of between 1 and 1, while an increase was defined as having a score over 1. These parameters were set based on the control data.
There was an increase in the percentage of cell bodies showing reduced expression of both complex I and complex IV in PD cases compared to other groups, and in DLB cases there was an increase in complex IV deficient neurons, however neither of these changes was significant due to the variability between cases . In addition to measuring deficiency within the neurons of the SN, mitochondrial density was also quantified. Using the signal intensity for porin immunoreactivity we categorised each neuron based on the z score for porin. We again found that there was no significant difference between the mitochondrial mass in cell bodies between any of our patient groups .
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Ermitochondria Signaling In Neurodegeneration
Neurodegenerative diseases including PD, AD, and ALS/FTD share several obvious features: they are characterized by progressive nervous system dysfunction, affect millions of people worldwide and there is still no cure for any of them. Furthermore, despite affecting different brain regions PD, AD, and ALS/FTD also share other characteristics suggesting that common cellular processes may converge.
Thus, whilst the precise mechanisms remain to be determined, a variety of cellular processes are damaged in all of them, including Ca2+ dysregulation, defects in axonal transport, neuroinflammation, loss of cellular proteostasis and mitochondrial dysfunction,,,,, . Remarkably, ERmitochondria associations, regulates all of those processes. The findings that alterations in ERmitochondria associations occur in neurodegenerative diseases have given rise to the hypothesis that damaged ERmitochondria signaling is a common potential therapeutic target amongst distinct age-dependent neurodegenerative disorders.
Fig. 3: Proposed model for endoplasmic reticulummitochondria signaling in PD
ERmitochondrial axis appears to be essential for the healthy neurons. Conversely, the disruption of this interaction may involve the develop of some processes as: mitochondrial dysfunction, induction of oxidative stress, calcium dyshomeostasis, autophagy defects or neuroinflammation, which induce neuronal damage and trigger neurodegenerative diseases as PD
-Synuclein
PINK1 and Parkin
DJ-1
Diabetes A Contemporary Risk For Parkinsons Disease: Epidemiological And Cellular Evidences
1Nutrition and Health Substantiation Group, Nutrition and Health Program, Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation , Adelaide, SA, Australia
2Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia
3Cellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, QC, Canada
4Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
5National Institute for Neuroscience , University of Cagliari, Cagliari, Italy
6Department of Psychiatry and Neuroscience, Université Laval and CHU Research Center, Québec, QC, Canada
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Restoring Mitochondrial Dynamics And Trafficking
Mitochondria form a complex network, the cohesiveness and shape of which is of direct functional relevance . Mitochondria are highly dynamic, constantly breaking off, spatially relocating, and rejoining the network. This is critical for neurons as their complex architecture requires mitochondrial relocation from the soma to dendrites, axons and synapses to meet regional metabolic demands . The majority of genetic PD proteins locating to mitochondria and mitochondria-ER contact sites are associated with processes influencing or influenced by mitochondrial dynamics and trafficking . A comprehensive summary of mitochondrial dynamics and trafficking in neuronal function can be found elsewhere .
Mitochondrial dynamics are highly complex but strictly balanced processes controlled by a diverse array of established and emerging molecular mediators, in addition to mitochondria-ER contact sites . Fragmentation of the mitochondrial network is a salient observation in PD, highlighting mitochondrial dynamics as a key therapeutic target. To this end, mdivi-1, an inhibitor of the mitochondrial fission GTPase Drp1, has been used to inhibit mitochondrial fragmentation in an -synuclein rat model of PD, reducing neurodegeneration, -synuclein aggregation, mitochondrial dysfunction and oxidative stress . While therapeutic manipulation of mitochondrial dynamics shows great promise, it will require greater understanding to be effectively exploited.
What Genes Are Linked To Parkinsons Disease
Several genes have been definitively linked to PD:
SNCA. This gene, which makes the protein alpha-synuclein, was the first gene identified to be associated with Parkinsons. Research findings by the National Institutes of Health and other institutions prompted studies of the role of alpha-synuclein in PD, which led to the discovery that Lewy bodies seen in all cases of PD contain clumps of alpha-synuclein. This discovery revealed the link between hereditary and sporadic forms of the disease.
LRRK2. Mutations in LRRK2 were originally identified in several English and Basque families as a cause of a late-onset PD. Subsequent studies have identified mutations of this gene in other families with PD as well as in a small percentage of people with apparently sporadic PD. LRRK2 mutations are a major cause of PD in North Africa and the Middle East.
DJ-1. This gene normally helps regulate gene activity and protect cells from oxidative stress and can cause rare, early forms of PD.
PRKN . The parkin gene is translated into a protein that normally helps cells break down and recycle proteins.
PINK1. PINK1 codes for a protein active in mitochondria. Mutations in this gene appear to increase susceptibility to cellular stress. PINK1 has been linked to early forms of PD.
GBA . Mutations in GBA cause Gaucher disease , but different changes in this gene are associated with an increased risk for Parkinsons disease as well.
Also Check: What Percent Of Population Has Parkinson's
How Can People Cope With Parkinson's Disease
While PD usually progresses slowly, eventually daily routines may be affectedfrom socializing with friends to earning a living and taking care of a home. These changes can be difficult to accept. Support groups can help people cope with the diseases emotional impact. These groups also can provide valuable information, advice, and experience to help people with PD, their families, and their caregivers deal with a wide range of issues, including locating doctors familiar with the disease and coping with physical limitations. A list of national organizations that can help people locate support groups in their communities appears at the end of this information. Individual or family counseling may also help people find ways to cope with PD.
People with PD may also benefit from being proactive and finding out as much as possible about the disease in order to alleviate fear of the unknown and to take a positive role in maintaining their health. Many people with PD continue to work either full- or part-time, although they may need to adjust their schedule and working environment to accommodate their symptoms.
Do Symptoms Get Worse
Can we cure Parkinson's by understanding mitochondria?
PD does not affect everyone the same way. The rate of progression and the particular symptoms differ among individuals.
PD symptoms typically begin on one side of the body. However, the disease eventually affects both sides, although symptoms are often less severe on one side than on the other.
Early symptoms of PD may be subtle and occur gradually. Affected people may feel mild tremors or have difficulty getting out of a chair. Activities may take longer to complete than in the past. Muscles stiffen and movement may be slower. The persons face may lack expression and animation . People may notice that they speak too softly or with hesitation, or that their handwriting is slow and looks cramped or small. This very early period may last a long time before the more classical and obvious motor symptoms appear.
As the disease progresses, symptoms may begin to interfere with daily activities. Affected individuals may not be able to hold utensils steady or they may find that the shaking makes reading a newspaper difficult.
People with PD often develop a so-called parkinsonian gait that includes a tendency to lean forward, taking small quick steps as if hurrying , and reduced swinging in one or both arms. They may have trouble initiating movement , and they may stop suddenly as they walk .
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Microglial Activation And Systemic Chronic Inflammation Increase The Risk Of T2dm And Pd
Microglia are mononuclear, phagocytic immune cells in the central nervous system. They are normally involved in removal of damaged neurons, and they release neuroprotective factors to promote synaptic regeneration . Microglia can be activated towards either an anti-inflammatory or inflammatory phenotype. For example, microglia can be stimulated by lipopolysaccharide to enter an activated inflammatory state and express pro-inflammatory cytokines such as TNF?, interleukin 1? and IL6, triggering neuroinflammation . A study of 14 patients with PD found evidence of increased microglial activation on PET imaging . Microglial activation is a key contributor to neuroinflammation through the release of inflammatory cytokines , and patients with PD have been shown to have high concentrations of inflammatory mediators such as IL1?, IL6 and TNF? in the brain .
What Diseases And Conditions Resemble Parkinsons Disease
PD is the most common form of parkinsonism, in which disorders of other causes produce features and symptoms that closely resemble Parkinsons disease. Many disorders can cause symptoms similar to those of PD, including:
Several diseases, including MSA, CBD, and PSP, are sometimes referred to as Parkinsons-plus diseases because they have the symptoms of PD plus additional features.
In very rare cases, parkinsonian symptoms may appear in people before the age of 20. This condition is called juvenile parkinsonism. It often begins with dystonia and bradykinesia, and the symptoms often improve with levodopa medication.
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What Is Parkinson's Disease
Parkinsons disease is movement disorder of the nervous system that worsens over time. As nerve cells in parts of the brain weaken or are damaged or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. As these symptoms become more obvious, people may have difficulty walking, talking, or completing other simple tasks. Not everyone with one or more of these symptoms has PD, as the symptoms appear in other diseases as well.
No cure for PD exists today, but research is ongoing and medications or surgery can often provide substantial improvement with motor symptoms.
Mitochondrial Dysfunction And Parkinsons Diseasenear
1Department of Physiology, National University of Singapore, Singapore, Singapore
2Division of Neurosurgery, Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
4Department of Research, National Neuroscience Institute, Singapore, Singapore
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Earlier Research On The Link Between Type 2 Diabetes And Parkinsons Disease
Some previous research has linked certain medications for type 2 diabetes to a lower risk of the development or progression of Parkinsons disease.
A found Parkinsons disease symptoms improved in participants who took exenatide, a diabetes drug in a family of medicines known as GLP1 agonists, and worsened when subjects took a placebo. Another , found that individuals with type 2 diabetes who took GLP1 agonists or another type of diabetes drugs known as DPP4 inhibitors had a lower risk of developing Parkinsons disease.
Slightly elevated blood sugar or variations in blood sugar may contribute to the risk of Parkinsons disease even in people without diabetes, according to a .
Age is the biggest risk factor for Parkinsons disease, though, and genetics also account for up to 20 percent of the risk, Foltynie says.
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Mitochondrial Fusion And Fission
The hundreds of mitochondria within a cell undergo continual cycles of fusion and fission , resulting in a wide range of mitochondrial morphologies . The adequate balance between fusion and fission is crucial for the maintenance of mitochondrial function. For instance, mitochondrial fusion is required for the proper respiratory activity of the mitochondria and has been associated with cell survival . In addition, the functionality of damaged mitochondria can be restored by exchanging mitochondrial genomes and gene products by fusion with neighboring, intact mitochondria, thereby attenuating the potential deleterious effects of misfolded proteins or mutated mtDNAs . The proper localization of mitochondria to nerve terminals also depends on the correct balance between mitochondrial fusion and fission, as fragmentation of the mitochondrial network by fission appears to facilitate the recruitment of mitochondria to nerve terminals .
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Linking Mitochondrial Dysfunction With Pd
The mitochondrial theory of PD is based on observations in which disease processes impairing oxidative phosphorylation, mitochondrial biogenesis or mitophagy manifest as phenotypes that share common Parkinsonian features. The first link between PD and mitochondrial dysfunction was conceived by Langston after observing rapidly developing Parkinsonian features in intravenous drug abusers who were exposed to 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine , a toxin whose metabolite 1-methyl-4-phenylpyridinium inhibits mitochondrial complex I . Once in the central nervous system, MPP+ is taken up by the dopamine active transporter and induces the selective degeneration of SNpc dopaminergic neurons. This phenomenon has been successfully reproduced in MPTP-treated rodents and nonhuman primates, popularizing these animal models for PD research . Complementing the findings in MPTP, rotenone, a pesticide that inhibits mitochondrial complex I, produced similar PD-like locomotor deficits in treated animals. Despite it having widespread uptake in the central nervous system, the toxic effects of rotenone are most pronounced in SNpc dopaminergic neurons, reinforcing the belief that neurons with greater susceptibility to energy perturbances would be affected the most . Further evidence is gleaned from epidemiological studies, which identified rotenone-exposed agrarian populations to be at greater risk of developing PD .
Origins Of The Link Between Mitochondria And Pd
What is Parkinson's Disease?
First, the so-called frozen addicts suggested a contribution of mitochondrial dysfunction to the pathogenesis of PD. In these drug users, living in California in the 1980s, physicians observed that a side product of new synthetic heroin triggered a rapid onset of a distinct form of parkinsonism responsive to levodopa treatment. It turned out that the synthesis process resulted in the unwanted generation of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine , which led to inhibition of the respiratory chain . Of note, a similar observation was published already four years earlier . MPTP is not toxic itself but lipophilic and thus able to enter brain tissue by crossing the blood brain barrier. In the brain, it is processed by monoamine oxidase B to the toxic cation 1-methyl-4-phenylpyridinium . MPP+is selectively taken up by dopaminergic cells and inhibits multiple complexes of the respiratory chain . The notion that mitochondrial dysfunction plays a role in PD pathogenesis was supported shortly after the description of the frozen addicts by the observation of a restricted function of respiratory chain complexes in postmortem brain sections from PD patients . These early findings significantly stimulated PD research in the following years. For example, even today, the injection of MPTP is most commonly used to model PD in mice . However, similar to other animal models of PD, the clinical and pathological characteristics simulated by the MPTP model differ from PD in many ways .
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The Mitochondrial Oxidative Phosphorylation System
Mitochondria are usually considered the powerhouses of the cell because of the production of ATP, via the combined efforts of the tricarboxylic acid cycle and the respiratory chain/oxidative phosphorylation system. The respiratory chain, located in the IMM, consists of five multimeric protein complexes: reduced nicotinamide adenine dinucleotide dehydrogenase-ubiquinone oxidoreductase , succinate dehydrogenase-ubiquinone oxidoreductase , ubiquinone-cytochrome c oxidoreductase , cytochrome c oxidase , and ATP synthase . The respiratory chain also requires two small electron carriers, ubiquinone/coenzyme Q and cytochrome c. ATP synthesis involves two coordinated processes: electrons derived from energy substrates are transported through the different mitochondrial complexes to molecular oxygen, thereby producing water; at the same time, protons are pumped across the mitochondrial inner membrane by complexes I, III, and IV, generating an electrochemical gradient . ATP is produced by the influx of these protons back into the mitochondrial matrix through complex V . ATP is the main form of energy used by the cell and, once produced in the mitochondrion, it is exported to the cytosol by the adenine nucleotide translocator in exchange for cytosolic ADP.
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You are in : All News > Tipa targets flexible plastics disruption after scoring US$70M compostable tech funding
Tipa targets flexible plastics disruption after scoring US$70M compostable tech funding
Tipa believes its compostable technology could disrupt the US$103B flexible plastic packaging market.
06 Jan 2022 --- Israeli compostable packaging specialist Tipa has landed US$70 million in a series C round funding in what it says will bring "breakthrough technology" to the world stage.
Speaking to PackagingInsights, Julia Schifter, Tipa's vice president of strategy analysis, says the investments – which were led by Millennium Food-Tech and Meitav Dash, who invested together US$30 million – now make the company a "world leader" in compostable packaging.
"The funds will be used to expand business and operations in all the key territories that Tipa already operates in, such as Europe, North America and Australia, as well as to expand into new markets and support new product launches," she says.
"This [expansion] will encompass some of the key application segments in flexible food packaging such as snack food, confectionery, coffee, cheese and meat. Funds will also be utilized to expand on strategic partnerships with key players in our supply chain."
Julia Schifter, Tipa's VP of strategy analysis.Fighting flexible pollution
Tipa aims to tackle flexible plastic pollution around the globe – a market estimated to be worth US$103 billion – by creating materials that can match the performance of virgin plastics but biodegrade or compost naturally.
Currently, just 4% of flexible plastics are recycled each year while contributing around 70% of ocean plastic pollution globally, according to Tipa.
"Our encounter with plastic packaging waste in our everyday lives has become a constant alarming reminder of the crisis we face as humanity. New solutions that move beyond plastic and beyond the failure of the recycling industry are required to solve this crisis," says Daphna Nissenbaum, Tipa's CEO.
"In recent years, we have witnessed a sharp increase in the demand for [environmentally] sustainable packaging solutions from consumers, while compostable packaging solutions repeatedly are ranked as the first choice of consumers around the globe."
Moreover, A Tipa-commissioned review from 2021 found "landslide expert support" for compostable packaging across the EU to reduce plastic contamination in organic waste streams and increase the amount of food waste captured for recycling.
Next-generation of compostables
An example of compostable Tipa packaging used for cereal.Schifter says Tipa's products' key environmental sustainability feature is their ability to integrate with the collection and treatment of food waste and, once composted, return to nature as a soil nutrient.
"One of the main developments in our upcoming new generation of products is a full range of packaging solutions suitable for either home, community, or industrial composting so our customers have multiple options for what to do with our packages post-usage."
"Renewable content in our new line of products will also increase to over 60%," she adds.
These developments are being recognized by industry. Foreseeing a "massive growth in the market demand for compostable packaging to replace hard-to-recycle plastics," multiple brands and retailers in the food and fashion industries have already adopted Tipa's solutions.
This includes Waitrose, Woolworth, Riverford Organic Farmers, Pangaia, and Scotch & Soda.
TIPA also recently signed a partnership agreement with Amcor, reportedly the world's largest plastic packaging manufacturer. The partnership aims to provide compostable packaging solutions to the Australian and New Zealand markets.
Flexing plastic policy
Despite compostable innovation and investments, companies like Tipa face regulatory hurdles in bringing products to market.
Last year, a UK consultation warned of miscommunication over packaging purporting to be compostable and the dangers of increased pollution resulting from consumer confusion.
Biodegradability depends on environmental conditions such as temperature, humidity, microorganisms present, and oxygen. According to the consultation, these materials have a "limited but valid role" in applications where conventional plastic is typically too contaminated to be reused or recycled.
However, Schifter says growing awareness of the benefits of compostable packaging is encouraging lawmakers to tighten accurate communication and help expand the market.
"Compostable packaging is new to legislators around the world. Yet, in multiple countries, including China, Chile, France, Italy and India, legislators are already either proactively supporting compostable packaging or are looking at supportive tools that will allow this new industry to flourish and offer a viable solution to some of the key hard-to-recycle plastics," she says.
"We expect to see more legislators around the world support compostable packaging in their fight against the plastic pollution crisis."
By Louis Gore-Langton
Tipa Millennium Food-Tech Meitav Dash Waitrose Woolworth Riverford Organic Farmers Pangaia Scotch & Soda Amcor TIPA Sustainable Packaging
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06 Jan 2022 --- Israeli compostable packaging specialist Tipa has landed US$70 million in a series C round funding in what it says will bring "breakthrough technology" to the world stage. Speaking to PackagingInsights, Julia Schifter, Tipa's vice president of strategy analysis, says the investments – which were led by Millennium Food-Tech and Meitav Dash, who invested together US$30 million – now make the company a "world leader" in compostable packaging.


I am an Australian ex-pat living in Singapore. I was encouraged by a relative to try WS after exhausting Bryce Courtenay's offerings in my homeland. For those who have read both, I'm sure you'll agree the similarities are often uncanny. I am not, for a moment, suggesting plagiarism; I appreciate both draw deeply on their African childhood and the wonderful, unique characteristics of the African people and landscape. I'm convinced Mr Courtenay (one of the less subtle similarities!) has been influenced/inspired by Mr Smith ... perhaps vice versa? Maybe I'm missing something more obvious? Do please let me know if I have stumbled into an area which has been discussed at length before.
I had the good fortune to be sent to Durban and Johannesburg for work a couple of years ago. I am sure this now adds significantly to the picture in my mind while reading WS. Similarly, I read Shantaram before this and felt myself transported to the (semi-familiar) streets of Bombay and loved the journey! I often wonder: does having seen a city or landscape where a book is set help to appreciate it?
Upon browsing this forum for just a few minutes, it would seem one of the most-discussed topics is the order one should tackle Mr Smith's work. I began with The Burning Shore. Eight books later I'm almost finished A Sparrow Falls. I'm quite sure this is not the best approach ... but having read The Burning Shore through to Golden Fox certainly hasn't tarnished my ability to enjoy When the Lion Feeds and beyond.
Having said that, I wouldn't say they're perfect, either. I occasionally find myself shaking my head in disbelief that one of those canny Courtney lads has, yet again, bumped into just the right person at just the right time ... you know: of-all-the-semi-arid-Kalahari-gin-joints kind of thing. But I console myself with the concept that these are not real-life tales of hardship to which I am supposed to relate to every last detail. The're about heroes and co-incidences and, as I said at the outset, magic.
I've bored you long enough. It's great to be 'in the house'/room. Now, if you don't mind, I'm returning to Lion Kop, where Mark Anders has just had a roll in the hay with Storm Courtney. Outrageous!
I'm glad you've ventured into the wide and wonderful world of forums, gothecon This isn't a chat room, as a chat would be a place online where you could have a real time conversation with more than one person. If you've ever used MSN messenger and the like, those are 'chats'. This is more of a bulletin board, albeit on-line. There are amazing boards (or forums) about every topic imaginable!
I'm convinced Mr Courtenay (one of the less subtle similarities!) has been influenced/inspired by Mr Smith ... perhaps vice versa? Maybe I'm missing something more obvious? Do please let me know if I have stumbled into an area which has been discussed at length before.
I don't we've ever discussed the similarities between the 2 authors. I've never read B. Courtenay, I tried once at the bookstore - couldn't quite get into him. Maybe I should try again!
Certainly doesn't hurt! I grew up in the southern African region and reading WS helps enhance my recall of the history of the different countries when I went to school there. Also helps me see places of my childhood with new eyes when I read his work A friend got me into "A Time to Die" when I was in high school in Botswana and I've been hooked ever since.


This listing is for a generous 11 ounces of emulsifying sugar scrub, blended by hand in small batches with no SLS/SLES, parabens, propylene glycol, -cones, animal products, coconut oil or shea butter (for my sensitive customers). Most of my fragrances are phthalate-free, too! I don't whip my scrubs, so you get a jar packed with product, not air.


Beginning in Fall 2019, Augsburg University will offer two annual, renewable scholarships that cover a minimum of 50 percent tuition to selected international undergraduate students dedicated to advancing intercultural learning and understanding.
First-year international applicants of any major to Augsburg University. International applicants are individuals who hold citizenship in a country outside the U.S. and who don't also possess U.S. citizenship or permanent residency.
Completion of a scholarship application and a 500-1000 word essay or a two-to-five minute video describing their aspirations to conduct projects, research, employment or other experiences that will advance intercultural learning.
How can I apply for this scholarship at Augsburg University?
1) Apply for admission to Augsburg University via the Common Application and submit all required application materials.
2) Complete a scholarship application, including a 500-1,000 word essay or a 2-5 minute video describing your aspirations to conduct projects, research, employment or other experiences that will advance intercultural learning.
All application materials must be submitted by December 15, 2018. You must be officially enrolled at Augsburg University and submit your enrollment deposit by May 1, 2019.


Best Training Practices: Where Are Your Training Monuments?
Where Are Your Training Monuments?
what are the highlights of your training work?
I recently joined members of the family in Washington, DC, for a week of monument-viewing and museum-prowling.
And they certainly have monuments there, huge, magnificent, awe-inspiring structures. Of course, the physical structures are there to remind us of the actions of the people they commemorate. For sure, many of these monuments are inherently impressive, but the ideas and actions behind them are the real story.
Now, if you were to send a visitor on a tour of the "monuments" to your training work for your company, what would be on the tour?
There might be some physical, or at least virtual, stops along the way. Perhaps you have a learning lab for certain things, or a state-of-the-art seminar room, or other tools of the trade that were the products of hard fought budget battles.
But the real "monuments" to your contribution to your organization are harder to see. If your sales figures are better than they were before you developed your sales training program, put those on the tour. If the safety record is better, or customer satisfaction is higher, if meetings are more efficient or turnover is lower, and training has contributed to that change, put that on the tour.
In short, the monuments to your training work are the enhanced results your internal clients have enjoyed as a result of the training you have created and delivered.
And I suggest you make this more than just a thought experiment. I suggest you create a list of monuments, that you take that "tourist's map of training monuments" seriously.
First of all, if you can't come up with any monuments to put on the map, what does that say about your training function? It could mean that you are delivering a lot of training, but not producing measurable results. Or you could be making a significant contribution, but one that you, and all your clients, are taking for granted.
Second, the monument tour is a great opportunity to have a chat with your clients, to make sure you both see the same monuments. On the one hand, it is easy to get used to good safety records or high productivity or low rates of ethical problems in the workplace, so that everyone forgets how vital ongoing training is to maintaining that contribution.
On the other, sometimes your clients have insights into your contributions that you might have overlooked. They see benefits to your training that go beyond, that add value to, the core training objectives, and given that they are on the front lines, their insights are particularly valuable.
Finally, engaging all of your staff in creating the tourist's map helps focus their attention on the clients, the company, and the real purpose of training. It helps them connect their activities to the real world of the business they are helping to succeed.
Monuments, I was reminded, can be inspirational. Make sure you, and your training staff, know where to find your own inspirational monuments to your training work.


After blogging yesterday morning, I finished the second sleeve for the sweater I was making for Mason. It was at that point that I realized that I was going to run out of yarn before finishing the shawl collar on that sweater. This is something I had feared for the last couple of days, and my fears were apparently well founded.
Mason seems to like his new sweater very much.
So after church, I came home and ripped out thefront of the sweater, then reknitted it as a crewneck sweater, which would require less yarn. I really didn't want to frog the whole thing, and I couldn't find the right dark blue to go with it to make it a two-tone sweater. The crew neck looks just fine, and Mason looks rather collegiate in it. I'm satisfied with the result.
This morning, I picked up a sideways-knit sweater that I started a few weeks ago to replace the sweater I put on the doll I gave Angela for her granddaughter. I don't know what I did to this new one, which was about 1/3 finished — and I did study it to try to figure it out— but I managed to drop or decrease several stitches from the front to the back, probably as I was knitting the sleeve. The back was about 5 stitches shorter than the front. In this case, the only solution was to frog back to the front and reknit the left sleeve. I have about half of the new sleeve knitted now. The sweater will look a lot better.
This Just Like You AG doll is getting ready for her trip to the Butterfly Ministry for Girls, where she will find a new home.
I've decided to give this sweater to the doll I will be sending to the Butterfly Ministry for Girls. It's very colorful and will look terrific with her tan skin. I bought a whole 1 lb. bag of this yarn last year to make doll clothes, and one sweater barely uses up any of it, so I will have plenty more to make my dolls another one. But I want to get this little sweetie on her way.
Toward that end, I took her apart today and tightened the elastic strings on her legs. She can stand on her own again, and she should be much happier. I'm sure the girl who receives her will enjoy her more with legs that don't wobble.
On Saturday, one of the girls who came to talk to me in Bridgewater told me how one of her grandmothers had made her American Girl doll a doll blanket, and that conversation has really spurred me to quickly get this little doll ready for the Butterfly Ministry. When I saw the joy in that girl's face as she talked about the dolls, I just wanted to make some other girl that happy. It might seem silly, but I am really excited about sending this doll down to the Butterfly Ministry organization as soon as I can, especially now that her legs are tight.
Gotta run. It's my last day off before I go back to work tomorrow.
Posted in Uncategorized on March 23, 2015 by Pam MacKenzie.


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Briefcase: Sept. 8
Briefcase is a roundup of new hires, achievements, awards and promotions in the business community.
Briefcase: Sept. 8 Briefcase is a roundup of new hires, achievements, awards and promotions in the business community. Check out this story on tallahassee.com: https://www.tallahassee.com/story/money/2019/09/07/briefcase-sept-8/2235144001/
Tallahassee Democrat Published 4:15 p.m. ET Sept. 7, 2019
Abby Dupree is one of thte 25 Women You Need to Know for 2018. (Photo: Special to the Democrat)
Carroll and Company, CPAs would like to congratulate Abby Dupree, CPA, CGMA on becoming the 2019 - 2020 Chair of the Board of Directors for the Florida Institute of CPAs. Dupree has served the FICPA in various roles at the local and state levels since 2004. She also serves as a Council Member for the American Institute of Certified Public Accountants (AICPA) and a member of the AICPA's Federal Tax Section. Dupree is the Managing Partner of Carroll and Company, CPAs. She has over 20 years of experience in individual, corporate, estate, trust and non-profit tax planning and preparation.
Varner (Photo: Chelsey Allder)
J. Morgan Varner has been hired as the Director of Fire Research at Tall Timbers. Tall Timbers has made significant investments in fire research, training, and outreach as a result of the institution's strategic plan goal to expand, improve and protect the use of prescribed fire. In this new position, Varner will coordinate Tall Timbers' local to international collaborations aimed at improving our understanding of fire behavior and predictions of fire effects on plants and animals. Varner has the background, knowledge, and expertise for the position. He has a Ph.D. in Interdisciplinary Ecology from the University of Florida School of Natural Resources & Environment.
Hunter (Photo: Submitted)
Olsen (Photo: Submitted)
Wells Fargo Advisors is pleased to announce that Jason Roper has joined Wells Fargo Advisors as a Financial Advisor. Jason will be joining family members Michael Josh Jordan, Managing Director-Investments and Kyle Crilow, Financial Advisor, both of Tallahassee.
Hopping Green & Sams congratulates Gary Hunter and Eric Olsen for their recent recognition in Best Lawyers 2020. Gary Hunter was named the Best Lawyers 2020 Litigation - Land Use and Zoning "Lawyer of the Year" in Tallahassee. Eric Olsen received the Best Lawyers 2020 Litigation - Environmental "Lawyer of the Year" in Tallahassee. Ten lawyers from Hopping Green & Sams were included in the The Best Lawyers in America 2020.
Alderman (Photo: Gittings Photography)
Giddings (Photo: Gittings Photography)
Buesing (Photo: Gittings Photography)
Platt (Photo: Gittings Photography)
Akerman LLP, a top 100 U.S. law firm serving clients across the Americas, announced that Florida Trend has named 25 of the firm's lawyers to its 2019 Legal Elite list. Akerman had the highest total number of lawyers listed, as well as the most women honorees. The firm's Legal Elite honorees include lawyers from offices across Florida, including Fort Lauderdale, Jacksonville, Miami, Orlando, Tallahassee, Tampa, and West Palm Beach. Partners David Ackerman, Silvia Alderman, Karen Buesing, Joni Armstrong Coffey, and Katherine Giddings were once again recognized among a distinguished group of practitioners in the publication's Hall of Fame. Florida Trend also identified five Akerman lawyers under the age of 40 who were named Up & Comers for their record of excellence in the legal community and represent the future of law.
Linn (Photo: Submitted)
Lewis, Longman & Walker Shareholder James W. Linn has been named Lawyer of the Year in Employment Law – Management in Tallahassee by U.S. News Media Group and Best Lawyers in addition to being named a Best Lawyer in Employee Benefits Law. An AV-rated attorney, Linn advises public employers and pension boards on federal and state laws pertaining to governmental retirement plans.
Johnson (Photo: Submitted)
Dobson (Photo: Arnold Abeller)
DeMeo (Photo: Arnold Abellera)
The following three attorneys in Baker Donelson's Tallahassee office have been named to the 2020 edition of Best Lawyers in America. Ralph A. DeMeo: Environmental Law, Litigation – Environmental; Stephen S. Dobson III: Criminal Defense: General Practice, Criminal Defense: White-Collar; Kelly Overstreet Johnson: Employment Law – Management.
Send your news to TLH-Briefcase_ Milestones@tallahassee.com.
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