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Rampage forward Craig Munro circles the Terrace net during Saturday night's 6-3 loss to the River Kings at Frank Pyde Memorial Arena.
VIDEO AND STORY: Rampage fall to Terrace in rough affair
Despite a third period comeback, the Rupert Rampage lost its first game of the season 6-3 to the Terrace River Kings in Prince Rupert.
Bevan Hamilton
Despite a third period comeback, the Rupert Rampage lost its first game of the season last Saturday night, 6-3 to the Terrace River Kings at Frank Pyde Memorial Arena.
The two rivals took things to another level, racking up 25 penalties and 110 penalty minutes in a rough game that left players and coaches frustrated after the final buzzer sounded.
"I thought the refereeing tonight was awful. It was horrendous, especially towards the end," said Rampage general manager and CIHL president Ron German, who specified it was awful for both teams.
As the game reached its climax in the last couple of minutes, things intensified and referees handed out seven penalties in the final 50 seconds alone.
Despite that, it's not the only reason the Rampage lost. There wasn't a lot that went right for the team.
"I'm not going to say we did much well. We were struggling in a lot of different things today," German said.
These two teams have now played each other three times in the past four games and it shows as the intensity of each game only increased. But German loves the rivalry.
"It's going to be a pretty exciting season, the battle between Rupert and Terrace all year. The rivalry is going to be huge," he said.
The Rampage are now 2-1 and sit behind only Williams Lake (3-0) in the standings, but it's a long season.
"I want them to work hard and bounce back. We've got a great crew this year and I just want to see us keep working hard and not implode and start taking stupid penalties," said German.
The Rampage (11) did take less penalties than Terrace (14) in the game, which hasn't been the norm, but the Rupert team is far and away from the rest of the league in penalty minutes. The Rampage have 116, while the River Kings are second with only 87. It's not a new problem this year, but it's something German repeatedly states he wants the team to improve on.
The rhinos struck first on a goal by Craig Munro in the first few minutes to the delight of a crowd of more than 750 people.
Just past the halfway mark of the period, River Kings rookie Robert Orrey tied it up on a breakaway. Rupert goalie Devin Gerrits made the initial save, but Orrey put in the rebound for his first CIHL goal.
But the close game was broken open in the second. Ben Reinbolt and Brett Downie scored less than two minutes apart early in the period to give Terrace a 3-1 lead. That shifted the momentum for the River Kings for much of the frame, as they dominated puck possession and were constantly challenging Gerrits, who made 24 saves on 29 shots in the game.
The Rampage thought they scored halfway through the period, but it was waved off, much to the dismay of a booing crowd. German said the team was all pretty positive the puck was in, but there was nothing they could do about it.
The game was highly physical from start to finish, with several players slow to get up at different times. In the third period, Rupert captain Jared Meers was checked and was slow to get back up and the River Kings scored on the same play. Kory Movold responded to the hit and ensuing goal by fighting Luke Gordon. Both players were ejected from the game and the referees spent a few minutes before confirming that the goal counted.
Now down 4-1, the Rampage kicked up the pressure. It finally paid off on a goal by Josh Cook, who fired one in the top right corner past Terrace goalie Darren Beaulieau, who made 33 saves.
Five minutes later, while on the powerplay, Jacob Santurbano hammered a slapshot into the net to bring the Rampage within one goal.
The "Let's Go Rampage" chants from the crowd were cut short when the River Kings scored with less than two minutes to play to take a 5-3 lead. Terrace also added an empty-net goal.
There were quite a few skirmishes and fights in the final minute that led to several players being thrown out. Jean-Luc Fournier and Luke Walker were given the boot for fighting, and several other players were also handed penalties.
The Rampage have the weekend off and will play the Steelheads in Smithers on Oct. 29.
VIDEO and Story: Basketball a way for Kevin Sawka to give back


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Our Ukraine Calls For Cross-Party Talks
Roman Bezsmertny, a key Our Ukraine figure in talks about the formation of a new government (file photo) (epa) June 13, 2006 -- President Viktor Yushchenko's Our Ukraine bloc has called for talks between all parliamentary parties after blocs formerly allied in the Orange Revolution failed to achieve a breakthrough in talks to form a governing coalition.
In a statement today, Our Ukraine said all political blocs that won seats in parliament elections in March should take "responsibility for the work of the legislative and executive branches."
Talks between Our Ukraine, the bloc of former Prime Minister Yuliya Tymoshenko, and the Socialist Party broke off on June 10 amid disagreements over the distribution of key posts.
Earlier on June 13, a senior Our Ukraine official, Roman Zvarych, said that "a coalition must be formed in any case" and that the party is free to look for other partners.
The pro-Russian Party of the Regions won the largest number of votes in the election.
(Interfax-Ukraine, UNIAN, "Ukrayinska pravda")
The Key Players
BEHIND THE IMAGES: Click on the links below to read RFE/RL's profiles of some of the key players in Ukraine's March 26 legislative elections:
Viktor Yanukovych Yuriy Yekhanurov Yuliya Tymoshenko Oleksandr Moroz Rynat Akhmetov Volodymyr Lytvyn
Click on the image for background and archived articles about Ukraine's March 26 elections.
Click on the image to see RFE/RL's coverage of the Ukrainian elections in Ukrainian.
Click on the image to view a photo gallery of some of the key players in the Ukrainian elections.
Our Ukraine Says Coalition Talks At Dead End
Building Coalitions -- And Nations -- In Ukraine
Pushkin's Anniversary Takes On Political Edge
New Parliament Sets Deadline For Coalition

redpajama_set_name: RedPajamaCommonCrawl


This gorgeous and handy Little Kid Backpack in the Green Robot design is made with a water-resistant and easy clean coated linen exterior. These Little Kid Backpacks come in cool designs and will be just right for your growing child.
The Green Robot backpack is a great bag for your child to take to day care, to carry snacks to the park, a sleep-over bag or even a great nappy bag.


text:
require "spec_helper"

describe Ohai::System, "plugin nodejs" do

  let(:plugin) { get_plugin("nodejs") }

  before do
    plugin[:languages] = Mash.new
    @stdout = "v0.8.11\n"
    allow(plugin).to receive(:shell_out).with("node -v").and_return(mock_shell_out(0, @stdout, ""))
  end

  it "gets the nodejs version from running node -v" do
    expect(plugin).to receive(:shell_out).with("node -v")
    plugin.run
  end

  it "sets languages[:nodejs][:version]" do
    plugin.run
    expect(plugin.languages[:nodejs][:version]).to eql("0.8.11")
  end

  it "does not set the languages[:nodejs] tree up if node command fails" do
    allow(plugin).to receive(:shell_out).with("node -v").and_return(mock_shell_out(1, "", ""))
    plugin.run
    expect(plugin.languages).not_to have_key(:nodejs)
  end

  it "does not set languages[:nodejs] if node command doesn't exist" do
    allow(plugin).to receive(:shell_out).and_raise(Ohai::Exceptions::Exec)
    plugin.run
    expect(plugin.languages).not_to have_key(:nodejs)
  end

end

redpajama_set_name: RedPajamaGithub


This is the first article of the two-part series: "How the Mobile Phone Revolutionized Africa". This first part focuses on Banking and Education, and the upcoming second part will focus on Disaster Management, Agriculture, and Health.
In a few years, the increase of mobile phone usage has transformed how people communicate and live in Africa.


No matter how many times I daydream about warm climates or sunny locales, I'm faced with the same reality when exiting my house: it's cold outside. In an effort to warm my body after venturing outside, I've expanded my repertoire of hot soups with this wonderful chicken corn chowder recipe.
There's something timeless about the preparing of soups. While we now have modern conveniences like slow cookers, I've always been enamored with photos and illustrations of the cast iron pot, over a crackling fire; each element of the soup or stew adding to what becomes a tasty, family feast. Those soup recipes have been handed down through generations for a reason: they result in some of the best products coming out of the family kitchen. No matter the culture or family dynamic, it seems everyone has a favorite soup recipe in their list of go-to meals.
Finding happiness in winter can be as simple as grabbing your favorite warm blanket and preparing that hot bowl of hearty, seasonal soup, which makes the frigid temps feel like nothing more than a nuisance. This recipe is easy enough to prepare when you're in a hurry, and it's likely you have most of the ingredients sitting in your kitchen. After all, a winning soup recipe should always be economical.
This recipe may seem like it would be overly heavy, but it's surprisingly lighter and so tasty. It could be a new favorite in the house!
Place oil, chicken, and onion into a dutch oven or similar stockpot.
Heat on medium heat until chicken is browned.
Stir in squash, barley, taco seasoning, and broth.
Heat on medium-high until boiling.
Reduce heat and cover, continuing to boil for 10 minutes.
Stir in black beans, corn, half & half, and salsa, Continue to heat until hot.
Serve topped with fresh cilantro.
For the holiday season, adding some seasonal flavor is always a great option, whether it's with the introduction of a favorite spice, vegetable, or garnish. For this chicken corn chowder recipe, we've added some butternut squash, which gives the dish some seasonal taste. For the vegetarians in your family, substituting the chicken with tofu pieces, and using vegetable broth in place of chicken broth, results in a dish you'll find just as tasty. Also, for those with the dreaded adverse reaction to cilantro, feel free to leave it out entirely; or try fresh parsley.
If you're looking for other chowder recipe ideas, this southwest chicken and lentil chowder is made in the slow cooker.
Share this recipe with someone who needs a warm belly!
I am always looking for new soup recipes to try, thank you! This Southwest Chicken Corn Chowder looks incredible and I can't wait to make it!
Sounds good and fast! And your photos are, as always, so enticing. I don't even like squash, but I'm going to give this one a try. Thanks for sharing!
This looks delicious! It looks like an easy recipe, too!


text:
Texas Executive Education
McCombs School of Business
competency-map
University Credit
Why Choose TEE
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Doug Dierking
Distinguished Senior Lecturer, Department of Management
Assistant Department Chair, Department of Management
Ph.D, The University of Texas at Austin
MEd, University of Missouri
BS, Central Missouri State University
Dr. Dierking is a Distinguished Senior Lecturer and the Assistant Department Chair in the Management Department at the McCombs School of Business, The University of Texas at Austin. He teaches graduate courses in sustainable leadership, leading people and organizations, creating and managing human capital and the art and science of negotiation. At the undergraduate level, he teaches courses in the art and science of negotiation, consulting, and change management and organizational behavior. He has been teaching at the university for over fifteen years. Dr. Dierking's research interests include organizational culture, effective employee on-boarding and retention practices, leadership development and succession planning.
Professor Dierking's excellence in teaching has been recognized numerous times, most recently with the Fawn and Vijay Mahajan Teaching Excellence Award for Executive Education, 2014 and on the McCombs School of Business Graduate Business Council Faculty Honor Roll, 2014, 2013, 2012, 2011, 2010, 2009, 2008, and 2007; Texas Evening MBA Outstanding Professor Award, 2010 and Texas Evening MBA Faculty Honor Roll 2014, 2013, 2012, 2011, 2010, 2007 & 2005; BBA Faculty Honor Roll 2013, 2012; Texas Exes Teaching Award - 2005; Lockheed Martin Excellence in Teaching Award – 2005; and Hank and Mary Harkins Foundation Award for Effective Teaching – 2005.
In addition to teaching at the University of Texas, Dr. Dierking is very active in the corporate and public sectors. He has worked extensively with Royal Dutch Shell internationally to develop and deliver training in leading project teams, particularly geographically dispersed or virtual teams for project engineers. He has provided training and consulting in the areas of negotiation, leadership, recruiting, on-boarding and retaining high performance talent, executive coaching and change management to a wide variety of companies such as Ecopetrol, Sinopec, Petrobras, Polycom, BBVA, Gulf States Toyota, Texas Instruments, Dell, Motorola and Emerson Electric (Fisher-Rosemount), as well as numerous smaller organizations.
Dr. Dierking currently serves on the Advisory Board of Directors of a large non-profit organization (Past-President) and has served on several community boards.
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With the development of 3D laser scanning technology, it is more and more popular to protect the buildings and promote reverse engineering with 3D laser scanning technology together with computer. However, due to the diversity and complexity of the building, the large amount of data generated in digitalization of buildings cannot guarantee an accurate expression of building model. In view of this problem, this paper presents a 3D reconstruction algorithm of historical and cultural buildings based on S-ICP algorithm, achieving the optimal transform by the least square method and meeting the convergence through "looking for corresponding point sets and calculating optimal transform". The simulation results show that the S-ICP algorithm model in this paper is superior to traditional algorithms not only in the time, but also in the registration precision. It effectively shortens registration time in the process of registration.
ICP algorithm, S-ICP algorithm, historic cultural buildings, 3D reconstruction.


text:
Quantum dots visualize tiny vibrational resonances
by American Institute of Physics
Background: Image of a Chladni plate's mode of vibration visualized by grains of sand collected at the nodes. Left-top: Cross-sectional scanning tunneling microscopy image of an indium arsenide quantum dot. Left-bottom: Variation of quantum dot emission line frequencies as a function of time due to vibrations of the photonic crystal membrane. Right: Scanning electron micrograph of a photonic crystal membrane, displaced according to one of the vibrational modes, with red and blue representing positive and negative displacement, respectively. Credit: Sam Carter and co-authors
In the late 18th century, Ernst Chladni, a scientist and musician, discovered that the vibrations of a rigid plate could be visualized by covering it with a thin layer of sand and drawing a bow across its edge. With the bow movement, the sand bounces and shifts, collecting along the nodal lines of the vibration. Chladni's discovery of these patterns earned him the nickname, "father of acoustics." His discovery is still used in the design and construction of acoustic instruments, such as guitars and violins.
Recently, investigators have discovered a similar effect with much smaller vibrating objects excited by light waves. When laser light is used to drive the motion of a thin, rigid membrane, it plays the role of the bow in Chladni's original experiment and the membrane vibrates in resonance with the light. The resulting patterns can be visualized through an array of quantum dots (QDs), where these tiny structures emit light at a frequency that responds to movement. The advance is reported this week in a cover article of Applied Physics Letters.
In addition to being a modern take on an old phenomenon, the new discovery could lead to the development of sensing devices as well as methods for controlling the emission characteristics of QDs. Since the light frequency emitted by the QDs is correlated with the movement of the underlying membrane, new devices for sensing motion, such as accelerometers, can be envisioned. A reverse application is also possible since the motion of the underlying membrane can be used to control the frequency of light emitted by the QDs.
The tiny devices in the work reported here consist of a 180-nanometer thick slice of semiconductor, suspended like a trampoline above a solid substrate. An array of QDs, analogous to the sand in the acoustic example, are embedded in the slice, whose thickness is less than one-tenth of one percent that of a human hair.
A second probe laser is used to visualize the resulting resonances. The QDs absorb the probe light and emit a second light pulse in response, which is picked up by a detector and routed to a display. The resulting patterns are remarkably like those visualized in Chladni's original acoustic experiment, even though the new device is driven entirely by light.
One possible application of this discovery, according to Sam Carter of the Naval Research Lab who is one of the paper's authors, is to sense subtle forces produced by nearby dense objects. "Concealed nuclear materials could be detectable," he said, "since dense materials like lead are used to shield the devices."
The highly dense shielding needed for nuclear materials causes small gravitational anomalies and tiny movements that might be detectable by a device based on the principle discovered here. The investigators plan to continue their work by looking at electronic spin. It is hoped that techniques to measure the effect on spin will increase the sensitivity of the devices.
Breakthrough in moving small objects using acoustics
More information: "Sensing flexural motion of a photonic crystal membrane with InGaAs quantum dots," Applied Physics Letters (2017). DOI: 10.1063/1.4995069
Journal information: Applied Physics Letters
Provided by American Institute of Physics
Citation: Quantum dots visualize tiny vibrational resonances (2017, October 30) retrieved 19 July 2019 from https://phys.org/news/2017-10-quantum-dots-visualize-tiny-vibrational.html
Researchers investigate Chladni patterns in a liquid at microscale
Vibrating nanoparticles interact: Placing nanodisks in groups can change their vibrational frequencies
Device for detecting subatomic-scale motion
New technique promises tunable laser devices
Device designed to exploit scattering of light by mechanical vibrations
Ultrasound-assisted optical imaging to replace endoscopy in breakthrough discovery
Quantum photonics by serendipity
Coupled exploration of light and matter
SLAC makes 'electron camera,' a world-class tool for ultrafast science, available to scientists worldwide
MEMS-in-the-lens architecture for laser scanning microscopy


The "Walpole Community Christmas Fund" — 3 to 4 Walpole churches fundraise annually (usually taking a collection at the ecumenical service on Thanksgiving) and also place "giving trees" throughout the community to support those in need with Christmas presents for the whole family, as well as financial support for food, clothing, rent deposits, heating fuel, and auto gas. The fund was managed and facilitated by the Unitarian Church for many years, but now I believe the Episcopal church has taken the lead. Our ecumenical youth group and Girl Scouts have done the legwork on and off, but I'm not sure who is currently spearheading the actual legwork.
Another thought was all the volunteers who bring meals to Walpole residents from the Alstead Fall Mtn. kitchen and also the Meals on Wheels up in BF.
And who coordinates the Walpole Memorial Day Parade and the 4th of July parade?
Thank you for the additional group ideas Virginia. Your suggestions were presented to the Selectboard at last night's (2/1/18) meeting. They agreed that the Old Home Day Committee should be added to the listing. I will contact them for follow-up.
Those organizations and Town committees/boards to be included on the inside front cover page of the Town Report do not receive financial support or payments from the Town. The list will be slightly edited to meet this requirement.
The Board felt that only civic organizations should be included although it was acknowledged that our religious communities are involved in outreach projects such as meals to the Warming Shelter, donations to the Fall Mt. Food Shelf, etc. If there are any questions regarding the Giving Tree Project and the Walpole Community Fund, please contact Rev. Susan Kershaw of St. John's Episcopal Church for more information.
The Fall Mt. Food Shelf and Friendly Meals does receive funding from the Town. There is a report from this organization, along with the Bellows Fall Senior Center in the Town Report.
The Memorial Day Parade is organized by the American Legion. They are included in the listing and have been contacted for a photo.
There are many that donate time, effort and materials beyond any stipend, donation or payment they receive from the Town, Their efforts are also greatly appreciated. However, we only have one page for dedications and there is criteria for inclusion for this year's grouping.
Additional feedback will be considered although our deadline is approaching quickly.


Among the many small improvements in Windows 8.1 Update 1 is a set of new settings in PC Settings that help you manage your PC. And key among these is the new Disk Space settings, which lets you check and manage how your PC's or device's storage is being used.
To find Disk Space settings, navigate to PC Settings, PC and Devices, Disk Space.
Here, you can see a rundown of how much storage is used overall on your PC, as well as how much is used by apps, pictures, videos, music, documents, and downloads. There's even a Modern interface to the Recycle Bin.
See which apps are taking up the most space. Tap on the "See my app sizes" link to view the App Sizes settings (which can be reached independently via PC Settings, Search and Apps, App Sizes). This interface lists your apps in order of size, with the largest first. To uninstall an app, select it and then tap the Uninstall button that appears.
(Manually) manage your documents media files. There's no interface here for managing your documents or media files per se, but if you see that one of these is taking up too much space, you could consider moving that content to a second hard disk (on a traditional PC) or a micro-SD card (on a tablet or 2-in-1). Windows does have an interface for automatically saving files to a secondary storage device: PC Settings, Navigate to PC and Devices, Devices and scroll down to Default Save Locations.
Empty the Recycle Bin. Yep, you can do that from here too.
Need more information about managing Windows 8.1? Please consider purchasing my Windows 8.1 Field Guide, a comprehensive guide to the new features in Windows 8.1 that costs just $2 for the e-book (PDF, EPUB, MOBI) version. You can find out more at the Windows 8.1 Field Guide web site.


Alberta Eaker Wortman, 94 of Casar Road, passed away, Thursday, February 7, 2019 at Testa Family Hospice House surrounded by her family that loved her and those she loved dearly.
A native of Cleveland County, she was the daughter of the late William George Eaker and Vernie Hoyle Eaker. After graduating high school, she and her husband ran Wortman's Grocery and retired after 47 years. She was a lifelong member of Corinth Baptist Church. Mrs. Wortman was a loving wife, mother, grandmother and great grandmother spending countless hours with her grandchildren. She was affectionately known as Granny to them. She loved her church family and community and was always caring and assisting those in need.
She was preceded in death by her husband, Joe Self Wortman; a son, Dempsey Wortman; two brothers and a sister.
Survivors include two sons, Dennis Wortman and wife, Rita of Casar and Devon Wortman of Mineral Springs; daughter-in-law, Lenore Wortman of Casar; grandchildren, Rebecca W. and Donald Peeler, Rachel W. James, Jennifer W. and Jimmy Summerlin, Judson and Amanda Wortman, W. Joe Wortman, John Wortman, Chelsey W. and David Felts, Todd Wortman and Darby Wortman; great-grandchildren, Andrew and Greyson Peeler, Madison and Dalton James, Daniel Felts, Hannah, Elijah and SiLi Summerlin, Baxter, Emma Grace and Elena Jo Wortman and two sisters, Pauline Downs of Casar and Billie Catherine Newton of Atlanta, Georgia.
The family would like to express deepest gratitude to Dr. Calvin Caunt and nurse Kim, Hospice of Cleveland County and to Shelby Manor for their love and kindness. She made many endearing friends while living there over the last three years.
A funeral service will be at 3:00 PM, Sunday at Corinth Baptist Church with Rev. Robert Goins and Rev. Norris Willis officiating.
Memorials may be made to Corinth Baptist Church, 323 Corinth Church Road, Casar, NC 28020 or to Hospice Cleveland County, 951 Wendover Heights Drive, Shelby, NC 28150.
To send flowers or a remembrance gift to the family of Alberta Eaker Wortman, please visit our Tribute Store.
"Email Address" would like to share the life celebration of Alberta Eaker Wortman. Click on the "link" to go to share a favorite memory or leave a condolence message for the family.


Mr. Gharaibeh possesses over 20 years of experience in auditing cities, counties and special districts, school districts and community colleges. He earned a master's degree in accounting and is a licensed California CPA. He is currently the managing partner of the Palo Alto office of Vavrinek Trine & Day and leads the firm's governmental audit group in northern California.


text:
ONTDEKKENBIBLIOTHEEK
Outdoor Photographer August 2020
Outdoor Photographer's blend of big, beautiful portfolios, in-depth how-to features, buyer's guides and product reviews combine to make it the premier magazine about nature photography. Our expert staff of editors and columnists is committed to giving you the tools, techniques and inspiration to capture your favorite subjects in a whole new light. Whatever your interest, Outdoor Photographer will inspire and inform you. Special Introductory Offer
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5 National Parks For Summer They're not too hot, not too crowded and they offer tons of summer-specific photographic opportunities. Photography by QT Luong Assignments Share your best shots in our weekly "Assignments" photo challenges. Submit your images that fit the week's theme—you may be our next Assignment winner. Tip Of The Week Available on our website—or delivered directly to your inbox—our "Tip of the Week" provides shooting and processing techniques to sharpen your photography skills. Sign up today. On Landscape William Neill's column on the fine art of landscape photography explores thoughtful approaches to composition and creativity. Connect With Us Get the latest news and be inspired by great photos from the Outdoor Photographer community. Newsletter Subscribe today for updates on the latest features, how-to articles and photography news. http://outdoorphotographer.com/newsletter/…
cover shot
Photographer: Zak Noyle Location: Honolulu, Oahu, Hawaii Equipment: Canon EOS-1D X Mark II, Canon EF 70-200mm f/4L IS USM Situation: Waikiki, the birthplace of surfing. The waters seen in this image are where it all began for the now-global sport. When flying into Oahu, planes take a path right over the waters of Waikiki, giving a glimpse of the surf below. These reefs have played the part of learning grounds for many surfers, including Duke Kahanamoku, an internationally known waterman who won five Olympic medals for swimming, including three gold medals, and played a major role in the popularization of surfing in the early 1900s. Growing up in Hawaii, my entire childhood revolved around the water, and the ocean has been a constant backdrop for my happiest memories. These days, I get to travel…
You never realize how the pieces of your life are fitting together as it's happening," Zak Noyle observes in the introduction to "The Surfing Life" in this issue. "Then one day, you find yourself swimming through a world-class wave making photos of the world's best surfers, and you take stock of how you got there." For pros—and especially those who photograph sports like surfing—a passion for the subject is the foundation of success. Just as wildlife photographers who study animal behavior have an advantage, sports photographers with a personal connection to their subjects are able to anticipate the action and distinguish an exceptional moment from the mundane, and the resulting images display that knowledge. Immersed in the lifestyle of the sport, photographers like Noyle make images that the passerby would…
After graduating from college, Tim Kemple moved into an old RV and wandered the world climbing rocks. Somewhere along the way, he picked up a camera, and years later, he can still climb 5.14 but is far more well-known for his iconic images of world-class athletes in wild places for clients such as Ram, Mitsubishi, Amtrak, Johnnie Walker and Wolverine. He also thrives helming light and fast film crews, informing an epic yet intimate, authentic style apparent in recent digital campaigns for Jaybird Sport, Merrell, The North Face and Apple. See more of Kemple's work at kemplemedia.com. Klemen Premrl ice climbing inside the Skaftafell Glacier, southern Iceland. "Over the past five years, I've traveled to Iceland several times to document outdoor athletes pushing the limits of their sport in the otherworldly…
get in the action
As impressive as today's interchangeable-lens cameras are, there are still some things they can't do on their own, like soar through the sky, dive underwater, clip inconspicuously to your backpack or take a serious tumble. For a unique point of view on adventure sports, these specialty cameras make it easy to capture images that would be nerve-wracking or even impossible with a traditional camera. THE "GO ANYWHERE" CAMERA Underwater, attached to your handlebars or tethered to your life jacket, the Sony RX0 II is a 15-megapixel ultra-compact camera that can go pretty much anywhere you can. Though it's incredibly small at 2.5x1.8x1.5 inches, it packs a 1-inch sensor that can capture stills—and 4K video with image stabilization—to microSD-format memory cards. The RX0 II is built to withstand the bumps and splashes of adventure…
pigeon spire
Location Bugaboo Provincial Park is located in the Purcell Mountains of British Columbia, Canada. The park contains isolated 10,000-foot granite spires soaring above ice fields and glaciers with stunning views in all directions. Access to the Bugaboos begins in the small town of Brisco on British Columbia Highway 95. Turn west onto Bugaboo Creek Road and navigate the maze of logging roads for 28.5 miles to the trailhead parking lot. The park provides chicken wire and wood posts to build a fence around the lower half of your vehicle, which prevents the porcupines from chewing the rubber parts off your car! The approach trail is steep, consisting of 2.8 miles and 2,360 feet elevation gain to the Alpine Club of Canada's Conrad Kain Hut, and another 0.6 miles and 820 feet elevation…
Guide to Mylio 2015
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Crusher manufacturers & suppliers. . Stone Rock Jaw Crusher of Mining Machine BRIEF INTRODUCTION The Jaw crusher is used for the . Stone crusher Manufacturers & Suppliers, China … stone crusher manufacturer/supplier, China stone crusher manufacturer & factory list, find qualified Chinese stone crusher manufacturers, suppliers, factories .


Fun, fresh air and frolics are promised for the sixth annual Dublin Kite Festival taking place on Sunday 10th June at North Bull Island, Clontarf. With free entertainment all day long, it's the perfect way to spend a summer Sunday with family and friends.
Don't worry if you've never flown a kite – or if you can't remember the last time you did – because there will be plenty of kiting experts on hand to get you off the ground! With lively music, exciting games, kite making workshops, a kite flying competition and buckets of enthusiasm you're sure to have a great day at Dublin Kite Festival 2018. Let's go fly a kite!
Brought to you by Dublin City Council and supported by 98FM.


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High Cholesterol Good for Hepatitis C Treatment?
Having higher levels of "bad" low-density lipoprotein (LDL) cholesterol is associated with a better response to hepatitis C (HCV) treatment in people infected with both HIV and HCV, say the authors of a study published in the May 11 issue of AIDS. This raises the question of whether a problematic side effect of many antiretroviral (ARV) drugs—increases in LDL—may actually be advantageous for people living with HIV undergoing treatment for HCV.
In people infected with HCV, but not HIV, studies have found that having a higher total cholesterol level and higher levels of LDL cholesterol is associated with having a sustained virologic response (SVR) to HCV treatment. An SVR is defined as an undetectable HCV viral load six months after completing HCV treatment. José del Valle, MD, from the Hospital Universitario de Valme in Sevilla, Spain, and his colleagues set out to determine whether the same thing would be true in people coinfected with HIV and HCV. From a cohort of 3,564 coinfected patients, del Valle's team analyzed data from 339 who had received HCV treatment.
In all, 39 percent of the patients who were treated achieved an SVR. People with a higher LDL cholesterol level (above 100 mg/dL) were more likely to have an SVR. This result was statistically significant, meaning that the difference was too great to have occurred by chance. Total cholesterol, however, did not influence whether people had an SVR. Given the beneficial impact of higher LDL on HCV treatment, del Valle's team concludes that further analysis of the use of various ARV drugs most likely to elevate LDL levels should be conducted.
#cholesterol
#LDL


is the Malaysian low-cost airline headquartered near Kuala Lumpur, Malaysia.
It is the largest airline in Malaysia by fleet size and destinations, and Asia's largest low-cost airline by passengers carried and jet fleet. AirAsia Group operates scheduled domestic and international flights to more than 165 destinations spanning 25 countries. Its main hub is klia2, the low-cost carrier terminal at Kuala Lumpur International Airport (KLIA) in Sepang, Selangor, Malaysia.
Its affiliate airlines Thai AirAsia, Indonesia AirAsia, Philippines AirAsia, and AirAsia India have hubs in Don Mueang International Airport, Soekarno–Hatta International Airport, Ninoy Aquino International Airport, and Kempegowda International Airport respectively, while its sister airline, AirAsia X, focuses on long-haul routes. AirAsia's registered office is in Petaling Jaya, Selangor while its head office is at Kuala Lumpur International Airport.
In October 2012, Air Asia's management said that they were keen to have more presence in India if the aviation environment and tax structure were conducive and friendly for low-cost airline operations. With the new Indian Government allowing a foreign direct investment of up to 49% in aviation sector, the airline CEO Tony Fernandes tweeted "Fantastic news that India has opened up investments to foreign airlines." He said that it was now easier for him to set up an airline in India. Tony Fernandes called the joint venture with Tata Sons a marriage made in heaven. He said that the Tatas know India very well and have a good reputation. A tie-up with the company would help AirAsia operate efficiently. Fernandes said that he would concentrate mainly on the one million south Indians who travel by rail. AirAsia announced its Indian low-cost affiliate airline on 19 February 2013. The airline would be operated as a joint venture, with AirAsia holding 49% of the airline. Arun Bhatia took up 21% and Tata Sons the remaining 30% stake in the airline. The joint venture would also mark Tata Sons' return to aviation industry after 60 years. AirAsia is the first foreign airline to set up an affiliate airline in India. The airlines is headquartered in Chennai and planned to make Chennai International Airport as its hub. Later, the primary hub of the airlines was shifted to Kempegowda International Airport, Bangalore. The maiden flight of AirAsia's India venture on Bangalore-Goa route took off on 12 June 2014. The airline announced that Indira Gandhi International Airport, Delhi will be its hub for North Indian operations.
AirAsia and Japanese network airline All Nippon Airways announced their joint venture at a press conference in Tokyo on 21 July 2011. Following its establishment in August 2011, AirAsia Japan flew its first flight in August 2012. AirAsia Japan was the first low-cost airline to be based at Narita International Airport. Its formation was announced only months after ANA had announced the formation of Peach, a low-cost airline based at Kansai International Airport in Osaka, and alongside a concurrent effort by Japan Airlines to set up a low-cost affiliate. ANA elected to partner with an existing low-cost airline for efficiency and strategic advantage. It was the fifth affiliate airline for AirAsia and the ninth for ANA. The airline was headquartered alongside ANA in Tokyo, with its main operating base at Narita, and served domestic destinations, utilising the brand and service model of AirAsia. Future planned international destinations included the Philippines, South Korea, and Taiwan.
In a press release on 1 July 2014 AirAsia announced a relaunch of the AirAsia Japan brand. The first flight is scheduled to depart in the summer of 2015.
AirAsia X is the long-haul operation of AirAsia. The franchise is able to keep costs down by using a common ticketing system, aircraft livery, employee uniforms, and management style. AirAsia X is also affiliated with Virgin Group and Air Canada. On 17 May 2007, Tony Fernandes announced plans to commence flights from Malaysia to Australia. Fernandes said he would be avoiding Sydney Airport due to its high fees. Instead, the airline would concentrate on cheaper alternatives such as Melbourne's Avalon Airport, Williamtown Airport in Newcastle, and Adelaide Airport. Sustained fares were predicted to be around MYR 800 (A$285) for a return fare, plus taxes. Interest was also expressed in using Gold Coast Airport as another Australian destination. On 14 May 2007, AirAsia confirmed that it had ordered 15 Airbus A330-300 aircraft, 5 more than originally announced. The aircraft were scheduled for delivery from the fourth quarter of 2008. On 27 March 2008, AirAsia signed a firm contract for another 10 Airbus A330-300s bringing the airline's total order to 25. AirAsia X received its first A330 on 31 October 2008 in Toulouse, France. As of 14 February 2008, 48% of AirAsia X is owned by Aero Ventures; a venture of Tony Fernandes, other prominent Malaysians, and Air Canada's Robert Milton. Virgin Group own 16% and a further 16% is owned by AirAsia. Bahrain-based Manara Consortium, and Japan-based Orix Corp have taken a 20% stake in AirAsia X for RM250 million.
At 1 March 2016, the fleet consists of 20 Airbus A330-300 aircraft. The airline also has 2 Airbus A330-300, 66 Airbus A330-900 and 10 Airbus A350-900s on order.
Indonesia AirAsia operates scheduled domestic, international services and is an Indonesian associate carrier of Malaysian low-fare airline AirAsia. Its main base is Soekarno-Hatta International Airport, Jakarta.Until July 2010, Indonesia Air Asia, along with many Indonesian airlines, was banned from flying to the EU due to safety concerns. However, the ban was lifted on July 2010. The airline was established as Awair in 1999 by Abdurrahman Wahid, former chairman of the Nahdlatul Ulama Muslim organisation. He had a 40% stake in the airline which he relinquished after being elected president of Indonesia in October 1999. On 1 December 2005, Awair changed its name to Indonesia AirAsia in line with the other AirAsia branded airlines in the region. AirAsia Berhad has a 49% share in the airline with Fersindo Nusaperkasa owning 51%. Indonesia's laws disallow majority foreign ownership on domestic civil aviation operations.
Indonesia AirAsia X is a joint venture of AirAsia X. It serves Indonesia AirAsia's regularly scheduled long haul international flights from Bali's Ngurah Rai International Airport. Indonesia AirAsia X launched its first flight to Taipei on 29 January 2015.
Philippines AirAsia is a joint venture between Filipino investors and AirAsia. The Filipino group include Antonio Cojuangco, Jr., former owner of Associated Broadcasting Company with flagship television station TV5, Micheal Romero, a real estate developer and port operator, and Marianne Hontiveros. The joint venture was approved on 7 December 2010 by the Board of Investments, an agency in the Philippines in charge of big ticket investments. AirAsia Zest Airways, Inc., operating as AirAsia Zest (formerly Asian Spirit, and Zest Air), is a joint venture between AirAsia & AMY Holdings Inc., the company who owns Zest-O corporation in the Philippines. It operates scheduled domestic and international tourist services, mainly feeder services linking Manila and Cebu with 24 domestic destinations in support of the trunk route operations of other airlines. In 2013, the airline became a sister airline of AirAsia Philippines operating their brand separately. Its main base is in Ninoy Aquino International Airport, Manila, and with a hub at Mactan-Cebu International Airport, Cebu. The airline was founded as Asian Spirit, the first airline in the Philippines to be run as a cooperative. It was rebranded to Zest Air on March 2008. On 16 August 2013, the Civil Aviation Authority of the Philippines (CAAP), the regulating body of the Government of the Republic of the Philippines for civil aviation, suspended Zest Air flights until further notice due to safety issues. Less than a year after AirAsia and Zest Air's strategic alliance, the two companies rebranded as AirAsia Zest on 18 September 2013.
Philippines AirAsia is one of the Philippine air carriers banned in the European Union. On 15 August 2011, Philippines AirAsia took delivery of its first brand-new aircraft, an Airbus A320 which arrived at Clark International Airport in Clark, Angeles City, Pampanga. On 8 November 2011, Philippines AirAsia took delivery of its second A320. On 7 February 2012, the airline received its Air Operator Certificate from the Civil Aviation Authority of the Philippines which gives the airline permission to fly in Philippine airspace.
Thai AirAsia is a joint venture between AirAsia and Thailand's Asia Aviation. Thai AirAsia launched domestic operations on February 2004. It serves AirAsia's regularly scheduled domestic and international flights from Bangkok and other cities in Thailand. Thai AirAsia was the only low-cost airline operating both domestic and international flights from the Suvarnabhumi Airport. The airline shifted all operations from Suvarnabhumi Airport to Don Mueang International Airport effective 1 October 2012. Thai AirAsia is 55% owned by Asia Aviation, 45% owned by AirAsia International. The airline sponsors the Thai football teams Buriram United, SCG Muangthong United, Chonburi, Osotspa Saraburi, BEC Tero Sasana, Chiangrai UTD, Esan United, Chainat, Samut Prakan CUTD, Bangkok United, FC Phuket, Krabi, Air Force United, Nakhon Phanom, Loei City, Trang and the referee of Football Association of Thailand.
Thai AirAsia X is Thailand's first long-haul low-cost airline. It was scheduled to begin operations in June 2014. After putting off the launch that had been planned for the first quarter, Thai AirAsia X was to launch its maiden service from Bangkok to Incheon, South Korea on 17 June and then begin regular flights to Japan's Narita Airport in Tokyo and Osaka around July.


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womens.caucus@house.state.md.us
Women's Legislative Caucus of Maryland
Supported Bills
Supported Bills: About
Women's Legislative Caucus
Legislative Review - Supported Bills
Click on the title to stay updated and learn more!
HB89 / SB480
Child Care Stabilization Grant Program and Child Care Expansion Grant Program - Established
Establishing the Child Care Stabilization Grant Program and the Child Care Expansion Grant Program in the State Department of Education; and establishing that the purpose of the Program is to provide financial support to licensed child care providers in the State that are in danger of closing in the next 12 months due to financial hardship.
HB104 / SB41
Family Law - Child Custody and Visitation
Requiring a court, in a custody or visitation proceeding, to deny custody or visitation rights to a party if the court finds by a preponderance of the evidence that a child has been abused or neglected by the party, unless the court specifically finds that there is no likelihood of further child abuse or neglect by the party and states the reasons for the finding; authorizing the court to approve a supervised visitation arrangement under certain circumstances; etc.
Institutions of Higher Education - Pregnant Students - Policy
Prohibiting an institution of higher education from requiring pregnant students to take a leave of absence, withdraw, or limit studies; requiring an institution of higher education to allow pregnant students, students who have recently given birth, and students who are the nonbirth parents of a recently born child to take a leave of absence and return to the institution in good academic standing, subject to a certain condition; requiring an institution to adopt and implement a written policy on pregnancy discrimination awareness; etc.
HB282 / SB316
Sales and Use Tax - Diapers - Exemption
Exempting the sale of diapers from the sales and use tax.
Interim and Temporary Protective Orders - Electronic Filing and Video Conferencing Hearings
Authorizing a petitioner receiving medical treatment at a hospital or an urgent care center to electronically file a petition for an interim or temporary protective order while at the hospital or urgent care center; requiring the court or District Court Commissioner to hold a hearing for an interim or temporary protective order through video conferencing under certain circumstances; and authorizing a hospital or urgent care center to allow an individual in their care to make an electronic filing or to attend a certain video conference.
Maryland Medical Assistance Program - Doula Program
Establishing the Maryland Medical Assistance Program Doula Program to provide doula services to program recipients who are pregnant or postpartum; requiring the Maryland Department of Health to administer the Doula Program; requiring a provider to meet certain requirements in order to participate in the Doula Program; and requiring the Maryland Medical Assistance Program to cover certain doula services, with certain limitations.
Civil Actions - Damages - Use of Race, Ethnicity, and Gender Data
Prohibiting a calculation of damages for loss of earnings resulting from personal injury or wrongful death from being reduced based on race, ethnicity, or gender; and applying the Act prospectively.
Maryland Medical Assistance Program – Doula Services – Coverage
Requiring a provider to meet certain requirements in order to provide doula services in the Maryland Medical Assistance Program and requiring the Maryland Medical Assistance Program to cover certain doula services.
Child Custody - Cases Involving Child Abuse or Domestic Violence - Training for Judges
Requiring the Maryland Judiciary, in consultation with domestic violence and child abuse organizations, to develop a training program for judges presiding over child custody cases involving child abuse or domestic violence and to review and update the training program at least once every 2 years; requiring the training program to include certain information; and requiring a judge who hears child custody cases involving child abuse or domestic violence to receive certain child custody training or continued training.
Maryland Medical Assistance Program - Personal Care Aides - Reimbursement and Required Wage
Requiring the Maryland Medical Assistance Program to increase the reimbursement rate for Program long-term services and supports by 15% on or before July 1, 2023; requiring a provider agency to pay to certain personal care aides a wage rate of at least $16 per hour on or before July 1, 2023; requiring a provider agency to submit certain cost reports to the Maryland Department of Health; authorizing the Department to take certain enforcement actions; etc.
Election Law – Candidate Expenditures – Caregiving Services
Altering the definition of "expenditure" to include reasonable expenses for certain caregiving services that a candidate incurs.
Education - Sexual Abuse and Assault Awareness and Prevention Program - Human and Sex Trafficking
Requiring the State Board of Education and nonpublic schools that hold a certificate of approval from the State Board and participate in the Nonpublic Schools Textbook and Technology Grants Program to develop and implement a program of age-appropriate education on the awareness and prevention of sexual abuse and assault that includes, for students in grades 6 through 8, material promoting the awareness and prevention of human and sex trafficking.
Domestic Violence - Protective Orders - Status Hearings
Authorizing a person eligible for relief under a final protective order to file a motion for a status review hearing to review the order and determine if further intervention by the court is necessary to protect the person eligible for relief; and requiring a court to promptly schedule a status review hearing after providing notice to the respondent.
Department of Human Services - Family Investment Program - Contract and Program Review
Requiring certain contractors with the Family Investment Program to provide services in a manner that complies with federal law; requiring certain Family Investment Program contracts with nongovernmental entities to be performance-based and with certain incentives; requiring the Department of Human Services annually to review certain contracts; and requiring the Department to hire a consultant to conduct a certain review of the Family Investment Program.
Supported Bills: Activities
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HOW DO I GET IN THE SMART-GUY CLUB?
July 5, 2012 -- I like to think I'm a reasonably smart guy, but the only time I can be sure of that supposition is when I'm ensconced in an airport club.
My theory is that avoiding the madding crowds at airports by having a club to duck into is the smartest thing I can do. I mean, what's the downside? I'm relaxed, comfortable and productive before or between flights or during a trip disruption while the rest of the flyers are in varying states of chaos. Anywhere in the world, at airports great and small, the scorecard always reads something like Me: Smart. Everyone Else: Not so much.
So you can imagine my delight when Chase Bank and Visa last week announced the VIP Lounge in the heart of London during the upcoming Summer Olympics. Located at 116 Pall Mall, the lounge will be open from July 26 through August 12 from 10 a.m. to midnight. All you have to do to gain entry is flash a Chase Visa card. And when you consider that Chase issues Visa cards tied to a clutch of hotels and airlines--including United, Marriott, Hyatt, InterContinental, Southwest and British Airways--the VIP Lounge will surely be the smarter-than-the-madding-crowd hangout for frequent travelers.
"It's going to be even better than an airline club," says David Gold, general manager of Chase Card Services. "How many airline clubs have food by Morimoto, visiting Olympic athletes and all sorts of by-reservation-only special experiences? The food selection and the ambiance really will make it feel more like a private club."
Gold knows airport clubs, by the way. When he's not riding herd on brilliant ideas like this pop-up city club, he rides herd on Chase's massively profitable United Airlines credit card portfolio. He's on the road all of the time. In fact, I had to catch up with him via telephone in Bordeaux, France, to get some of the juiciest details on the VIP Lounge.
The club will offer all Chase cardholders complimentary continental breakfast and lunch, tea, snacks and beverages throughout the day. Located on the lower level of the Institute of Directors building, the lounge will have a sophisticated bar area. There'll be plenty of televisions around--all tuned to Olympic coverage, I presume. There'll also be computer access and free WiFi, no inconsiderable perk when you consider the insanely high price of Internet access at London hotels.
"I have no idea" how many Chase cardholders will visit during the Games, Gold admits, "but our goal is to have people there." He's also quite confident that the VIP Lounge will be hopping because of the popularity of the pop-up lounges that Chase has operated during the Christmas holidays at the Short Hills Mall in New Jersey and the Galleria Mall in Houston.
And he says "several thousand customers" have already confirmed their attendance at the "culinary experience" that Chef Morimoto himself will host each evening during the lounge's run. "You'll get everything you'd get at one of his restaurants," Gold says proudly.
Of course, members-only clubs and lounges were a staple of London life when the British capital was the seat of the British Empire. Some are still around. But club life isn't what it was--in London or in any major city--and business travelers are often in need of a cool place to hang during the work day.
Regus, the short-term office-rental chain, claims to have Business Lounges in hundreds of cities around the world. But I've never thought Regus was serious when it came to courting business travelers. The payment plans, terminology, perks, prices and membership levels and schemes change so frequently that most road warriors I know gave up on Regus years ago.
A start-up firm called Dayuse Hotels has forged agreements with hundreds of properties in Europe to rent lodgings for business-day use. It recently premiered in New York, offering day-use prices at more than a dozen Manhattan properties. But rates are way too high and the company now sells itself more to "romantic lovers" than business travelers. We road warriors are big spenders, but folks looking for discreet nooners probably are a more profitable market.
So even if it's just for 18 days during a worldwide sporting event, I think Gold, Chase and Visa are on to something here. They may not have plans to roll out in-city lounges on a permanent basis, but they should think about it.
After all, Gold says the goal of the VIP Lounge in London is about "want[ing] people to know that Chase cards are about more than spending and earning points."
I know I'd take any credit card that came with access to a network of in-city clubs that offered a place to perch for a few minutes or a few hours and check E-mail, catch up on work between meetings and have a beverage in a relaxing atmosphere.


Possessing a strong desire to reinvent education for the 21st century, Jade Moffat has been described as someone who "never sets limits on herself or others" and "is living proof of the power of thinking outside the box to realise powerful outcomes for young people".
She was recently recognized by The Educator magazine as one of Australia's most outstanding educators.
Starting as a high-school teacher, Jade is currently leading IBM's adoption of the P-TECH education model in Australia and is a major advocate of new collar jobs. Prior to this, Jade led National Australia Bank's education programs. Jade works across both the education sector and the corporate sector which makes her wealth of knowledge across the two industries very solid.
KidSmart early learning program is designed to teach technology to underprivileged preschoolers who might not have the resources to access technology at home. Preschoolers often become confident in technology by the time they reach school age. An independent evaluation of the KidSmart Program in Australia has shown that children participating in the program have improved their sharing, listening and cognitive skills.
Each Kidsmart centre also receives quality training from teacher programs run by IBM's partners. The workshop introduces teachers to the adequate technology requirements needed to facilitate the learning process. Teachers are encouraged to network with their peers to share ideas and build confidence in their skills. Networks available to KidSmart teachers and early childhood educators extend into Asia Pacific, Australia and New Zealand.They then go on to impart their knowledge on teachers from countries like China and India.
Over 1,279 centres have KidSmart programs set up around Asia Pacific. KidSmart has also been very successfully integrated into indigenous education programs in NSW, WA, SA and NT.
IBM also partner with The Smith Family to facilitate a mentoring program called i-Track for school aged children. i-Track supports high school children from financially disadvantaged backgrounds. It helps the children transition from school to work, by pairing them with IBM mentors who offer experience, encouragement and advice.
IBM volunteers also mentor tertiary students through their IBM-Victoria University partnership. It is a final year mentor program that offers IT students guidance on post university plans.
These are some of the programs that Jade Moffat runs to really integrate children and students from underprivileged backgrounds to receive the training and soft skills that they need to progress into an ever changing workforce.


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Police Impersonator Pulls Woman Over
By Nancy Arsenault
Stow and Maynard police are issuing a warning to local motorists to be on the lookout for a "police impersonator". A young woman from Stow reported to police on August 22 that a car was following closely behind her as she traveled through the eastern towns on Rt. 117, heading to Stow after work, around 12:45am. Near Erikson's Ice Cream, the car activated a blue flashing light, and thinking it was the police, the woman pulled over.
A man left the vehicle and approached her car. The woman noticed he was not in uniform, nor did he display any kind of badge. "She was immediately suspicious," said Stow Police Detective Mike Sallese. The man ordered the woman out of the car, and when she asked his reason for the request, he again ordered her out of the car. She did not comply, rolled up her window and quickly drove away. "She did do the right thing," added Sallese, who said most law enforcement vehicles in Stow and nearby towns are easily identifiable as a police vehicle. The officer would be in uniform and should also display identifying information, visible to the driver. Sallese said it is protocol that any officer identify themselves and their affiliation to someone they pull over in a motor vehicle stop.
In this case, the woman called police as soon as she arrived home and though several police cars from both Maynard and Stow searched the area, the vehicle and its driver, were not located. The vehicle was described as a dark colored sedan, similar to a police cruiser, with a single blue strobe light on the dash board. The suspect is described as a white male in his 40s, with short brown hair, facial acne scaring, a feminine voice, standing over 6ft tall and weighing about 225 lbs.
If anyone has any information about this or similar incidents in this area, please contact Detective Seeley at the Maynard Police Department at (978) 897-1011.


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Iced pour-over is a simple and approachable way to make rich, full-flavoured iced coffee one pitcher at a time.
For pour-over, use coffee ground for a paper cone. It's a relatively fine grind that looks like granulated sugar.
Iced pour-over is brewed at double strength and diluted with ice, so measure 4 tablespoons of coffee for every 6 ounces of hot water.
Use hot water that's just off the boil and fill the cone halfway to saturate the grounds. Pause for 10 seconds and let the coffee bloom. This lets it hydrate evenly and begin to develop flavour.
Slowly add the rest of the water, pouring in small, steady circles to cover all the grounds.
Pour your brewed coffee over fresh ice to chill, and serve immediately.
TIP: African coffees are popular for iced pour-over because of their superb juicy body, and tangy, sparkling citrus notes.


O God, our joy and our comfort, we gather in your name to give thanks for all the gifts of this day. Our spirits abound with your gift of joy. Comfort us with your presence that we may be strengthened to continue to proclaim your goodness in all the earth; through Jesus Christ our Savior. Amen.
O God of power and paradox, we confess our preference for life that is predictable. For goodness and love, honesty and fairness which have certain reward. But our experience also shows us the fallacy of such expectation. Good people do suffer while evil seems to go unpunished. We confess the difficulty in trusting you when trials and troubles, sickness and sorrow come upon us. Forgive us when we succumb to fear, hesitating to live fully because of the unknowns we face. Strengthen us to quietly and faithfully remain steadfast.
Go on up to a high mountain, O Zion, herald of good news; lift up your voice with strength, O Jerusalem, herald of good news; lift it up, fear not; say to the cities of Judah, "Behold your God!" Behold, the Lord God comes with might, and his arm rules for him; behold, his reward is with him, and his recompense before him. He will tend his flock like a shepherd; he will gather the lambs in his arms; he will carry them in his bosom, and gently lead those that are with young.
So again Jesus said to them, "Very truly, I tell you, I am the gate for the sheep. All who came before me are thieves and bandits; but the sheep did not listen to them. I am the gate. Whoever enters by me will be saved, and will come in and go out and find pasture. The thief comes only to steal and kill and destroy. I came that they may have life, and have it abundantly. "I am the good shepherd. The good shepherd lays down his life for the sheep.


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Businessman builds new dorm, pays room & board for poor students
Cỏ May Dormitary is located inside HCM City University of Agriculture and Forestry. VNS Photo/Ngọc Hải.
When the Cỏ May Dormitory opens in early September, at least 400 poor, talented students from HCM City and neighbouring provinces will have a free place to stay, thanks to the generosity of late businessman Phạm Văn Bên.
Located at the HCM City University of Agriculture and Forestry, the four-story, 54-room building was funded by Bên, former head of the Đồng Tháp Province-based private enterprise Cỏ May Ltd.
Besides the investment VNĐ37 million (US$1.7 million), Bên also asked his family to provide annual financial support of VNĐ15 billion to pay for school fees, meals and other expenses for students at the dormitory, according to his son, Phạm Minh Thiện.
"Our family will realise my father's wish," Thiện says.
Nguyễn Thị Bao, head of the Cỏ May Dormitory management board, says the applicants for the dormitory are students from poor families who have good academic records and have passed entrance exams for public universities.
"Mr Bên is a kind-hearted person," Bao says. "I recognised his kindness when I met him 27 years ago. VNS
Lê Hùng Vọng


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(Getty/RichLegg)
My father, his honor: Losing his prestigious job likely saved his life
Watching my father survive a public professional humiliation taught me far more than any of his successes
Check out this article! https://www.salon.com/2019/06/15/my-father-his-honor-losing-his-prestigious-job-likely-saved-his-life/
Susan Jane Gilman
Recently, an officer ushered me into the Bronx County Family Court. Around me were families steeped in tension and misery, locked in custody battles, divorcing, seeking restraining orders. I shared their anxiety — though for different reasons. I was coming to court to see my father.
The judge.
The last time I'd seen him on the bench — some 35 years ago — it hadn't gone at all well. It had ended for him, in fact, with a very public humiliation.
My father had first been named to the New York Family Court in 1983 by Mayor Koch. It was an unusual appointment: my dad was a social welfare lawyer, not a political animal. That he was an attorney at all was surprising. As a child, he'd been a stutterer, and in college, he'd had such trouble pronouncing words, he failed French four times. Whenever he got nervous, his tongue seemed to trip over itself. His malapropisms were legend. (For example, he often said "Oback Barama.")
Stunningly, he chose a profession that required him to speak publicly on a regular basis. Being a judge, though, was never his ambition. Rather, it was the dream of his father. My grandfather was a working class man from the Bronx whose own dyslexia was so profound, he bordered on illiterate. He longed to see his firstborn son defy all limitations and land a judiciary position. When my father received his judgeship, my grandfather was ecstatic. Yet just three weeks later, he suffered a massive stroke. He never lived to see my father's swearing in.
When my dad took the bench, he was just 44 years old — and grieving.
At home, he had liked to dance to Otis Redding. He was quick with a bear-hug, a joke, a wink. But when I first visited his courtroom, I saw a stranger. In his black robes, he was short-tempered, imperious. He banged his gavel a lot and ordered people around dismissively. His arrogance took me aback. Was this my dad?
Nearly overnight, his thick dark hair turned gray. He came home from work mute and drawn. "What happened in court today?" we'd ask.
"I can't discuss it," he'd mumble. "Child abuse cases."
My father was at the pinnacle of his profession, yet he seemed to disappear. He grew absent from our dinner conversations — and from the political networks that had endorsed him.
Three years later, when his judgeship was up for review, he was not reappointed. In a single afternoon, he went from being "Your Honor" to being unemployed. His disgrace was swift, personal, and very, very public.
What's more, he was our family's primary breadwinner. He'd lost everything: how would we pay the rent?
Within days of his firing, he re-started his career at square-one — taking assignments as a $35-hour court-appointed lawyer, appearing before the very same judges with whom he'd shared chambers just the week before. If this humiliated him, he didn't mention it. Client by client, he built his own modest, family law practice. The twinkle returned to his eyes. He grew confident, good-humored again. After weathering a public, political trouncing, he emerged a better man doing far better work.
Losing his judgeship likely saved his life.
And it profoundly shaped mine, too.
Parents often say they want to be successful in order to be role models for their children. But watching him survive a huge professional, public, and very personal humiliation taught me far more than any of his successes.
Being a writer requires enormously thick skin. You're never sure if you'll ever get published, paid, or read — and if you are, there's a high likelihood that your work will be pilloried. Watching my father endure disgrace with dignity — and revive his career without missing a day's work — gave me the fortitude to follow my own star, to surmount the self-doubt and criticism that come with being a writer. Any time negative reviews get posted about my books on Amazon — or haters target me on social media— or nasty comments have appeared below my commentaries for NPR — I'd thought of my father. His greatest professional failure equipped both of us with the tools to succeed. It modeled for me how to bounce back.
And his professional story has a happy ending after all. Just as he was about to retire as a lawyer, he was asked to resume the bench as a Judicial Hearing Officer — a part-time judge endowed with full authority in court.
At first, I couldn't understand why, in the twilight of his life, he wanted to subject himself to such punishment again. "When I first became a judge, I was too young. I wasn't sensitive to the political realities of the job. In my insecurity, I became disdainful. But now that I'm older, I think I really could be a good judge," he said wistfully. "I still want to contribute."
Me, I worried. My father had grown slower over time. He'd developed a habit of speaking very deliberately— his voice rising and falling in steady, pedantic waves. Smart-alecks that we were, my brother and I loved to mimic him. "Well . . . you . . . know," we'd say, exaggerating our father's labored pauses, "I really like Oback Barama."
Entering the court system again seemed misguided to me, a vestigial hubris. But my father was insistent. He became a JHO and urged me to visit him.
At first, I resisted. But then it occurred to me: my dad was now the age that his own father had been when he died. I was not going to miss out on seeing him on the bench. "OK, I'll come," I said reluctantly. "Just for one morning."
And so, finally, some 35 years later, I found myself stepping back into his courtroom.
Family Court is King Solomon territory: Who gets the baby? Who legally counts most as family? Who requires protection?
As soon as the session begin, my father was presented with one heartbreaking story after another. A 20-year-old college student, desperate to raise his baby daughter single-handedly. Two poor, immigrant newlyweds demanding restraining orders against one another. A teenaged girl abused by a crack-dealer, now fighting for custody of their three-year-old twins.
Who gets the children? Who requires protection? It fell to my father to decide.
Yet when he addressed the litigants now, he never banged his gavel. Instead, he spoke in the same slow, drawn-out tone my brother and I often mocked. In the courtroom, this voice had a wholly different effect. It lowered the temperature; hot-headed litigants instantly calmed down. And since many of them did not speak English as their first language, they understood my father perfectly. My father's speaking voice had not been shaped by his apraxia, I realized, but from years of negotiating volatile courtroom situations as a lawyer. He had turned his own shortcomings into an instrument of diplomacy and power.
He presided over his courtroom with solemnity, reasonableness, and compassion. Other judges routinely stopped by to observe him. "You father is one of the best judges in the city," one of them whispered.
He was finally the revered, respectable judge that my grandfather had once dreamed he could be — but on his own terms, on his own merits, and in his own time. In his 70s, my father was still determined to "do good." And I still had so much to learn from him. I canceled my other plans. For the rest of the day, I sat in his courtroom, teary-eyed, proud, watching him, mesmerized by how far he'd come and by the wisdom and cadence of his voice.
Susan Jane Gilman is the author of "Donna Has Left The Building," on sale now from Grand Central Publishing. She is the New York Times bestselling author of "Hypocrite in a Pouffy White Dress," "Kiss My Tiara," "Undress Me in the Temple of Heaven," and the novel "The Ice Cream Queen of Orchard Street." She has provided commentary for NPR and written for the New York Times, Los Angeles Times, and Ms. Magazine, among others.
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15 April, 2015 - 01:19 lizleafloor
New Study says early humans migrated into Europe due to warming climate
Rising temperatures approximately 1.4 million years ago might have assisted the migration of hominins out of Africa and into Europe, a new study suggests.
Dr. Jordi Agustí and colleagues have published a study in the Journal of Human Evolution that argues that prehistoric climate change affected the location and amount of resources available to our early ancestors. These early humans are thought to have benefited from shifting climate patterns, as the warming environment facilitated migration and access to food.
Model of adult female Homo erectus, one of the first truly human ancestors of modern man. Wikimedia Commons
Agustí, research professor of the Catalan Institution for Research and Advanced Studies (ICREA), finds that the spread of hominins was halted by colder temperatures and glacial cycles during the early Pleistocene era. There is a lack of evidence of human presence in Europe during this epoch.
However, archaeological finds from Spain suggest that once the climate conditions became favorable, early humanity was able to migrate.
Tracking Human Migrations through … snails
Ancient artifacts and human remains surface as glaciers melt
How Aboriginal Australians Survived the Last Ice Age
Evidence for the oldest hominin found in Western Europe is a tooth and stone tools. The tools were excavated in 1993 at the Barranco León site in the Guadix-Baza Basin of southeastern Spain. The Oldowan-styled stone tools date back to 1.4 million years ago, reports Popular Archaeology .
The stone tools are thought to have been used on herbivore mammals, as well as bodies scavenged after carnivore predators were finished with them. These traces of early human hunting and habitation indicate a migration of hominins out of Africa and into a vastly different landscape.
Through analysis of microvertebrate in deposits at the Barranco León site, researchers were able to determine the mean annual temperature of the nearby ancient lake. They found the period was characterized by warm temperatures and high humidity. This climate record corresponds to the stone tool and artifact timeline .
Researchers excavate the site at Barranco León. Screenshot via Excavación en Barranco Leon en Orce
ZeeNews reports, "The researchers said the early Pleistocene era (the era lasted from 2.59 million to 11,700 years ago) was characterised by colder and drier weather. 'This possibly impeded the settlement of this region by the early hominin population from the southern Caucasus'. […]But shortly afterwards, 'when the climatic conditions were again favourable, a hominin presence is suddenly evidenced."
Ultimately, the researchers conclude in the study that the data "clearly support the idea that the early hominin occupation of Europe was strongly constrained by climatic and environmental conditions, rather than by physiography or cultural factors."
Prehistoric Skull and Jaw Found in Laos Rewrite Timelines and Reveal Diversity of Early Humans
The Chickasaw Migration Story: Journey from the Place of the Setting Sun
White Skin Developed in Europe Only As Recently as 8,000 Years Ago Say Anthropologists
According to the findings of Dr. Agustí, the climate of millions of years ago created a vital transitional period for humanity's ancestors. Climate seems to remain a transitional force to this day. As the climate continues to change, ancient artifacts and significant human remains resurface , bringing us more information on the prehistoric past, enabling us to understand the overarching story of humanity and our place on this planet.
Featured Image: Pleistocene of Northern Spain showing woolly mammoth, cave lions eating a reindeer, tarpans, and woolly rhinoceros. Wikimedia Commons
By Liz Leafloor
hominins
early human
Liz Leafloor is Editor, Writer and Graphic Designer for Ancient Origins.
Having worked in news and online media for years, Liz covers exciting and interesting topics like ancient myth, history, technology, archaeological discoveries, life and death, and the unexplained.
Liz has been... Read More
Viking Runestone Uncovers Climate Fears That Fed Ragnarök Myth
Much of the modern world is very worried about climate change and it appears that Vikings were also very concerned about changes to the climate. Researchers now argue that one of the world's most...
Read more about Viking Runestone Uncovers Climate Fears That Fed Ragnarök Myth
21 December, 2019 - 19:00 Ed Whelan
Neolithic Wall is the World's Oldest Sea Defense System
In Israel, archaeologists have found evidence of what could be the oldest sea defense wall. The Neolithic wall is up to 7000 years old and was built by a community as they battled against rising sea...
Read more about Neolithic Wall is the World's Oldest Sea Defense System
17 December, 2019 - 19:19 ashley cowie
3500-Year-Old Minoan Cup Proves Ancients Weren't Green Either
A disposable Minoan cup forged by the early Mediterranean civilization will be displayed in a "stunning showcase," which evaporates the cultural myth that 'single-use' crockery is a modern creation...
Read more about 3500-Year-Old Minoan Cup Proves Ancients Weren't Green Either
4 December, 2019 - 23:04 Dr Pat Hanratty
Cataclysm, Mass Extinctions, and the Consequent Myths
According to geologists, in the interval from 10,000 to 8,000 BC, some 35 to 45 species of large mammals became extinct. This is called a mass extinction . Mass extinctions can be defined as species...
Read more about Cataclysm, Mass Extinctions, and the Consequent Myths
25 October, 2019 - 01:47 ancient-origins
A Dusty Demise for the Akkadian Empire (New Study)
The Akkadian Empire was the first empire in Mesopotamia and arguably the first true empire that existed, being around during the third millennium BC. As has been a recurring empirical theme ever...
Read more about A Dusty Demise for the Akkadian Empire (New Study)
10 September, 2019 - 18:51 ashley cowie
Ancient Cave Crystals Reveal Sea Levels Were 50 Feet Higher in Warmer Climate
Scientist studying ancient crystals in a Spanish cave have discovered disconcerting evidence that shows just how high sea levels can rise in a warmer climate. 4.4 million years ago, one of your...
Read more about Ancient Cave Crystals Reveal Sea Levels Were 50 Feet Higher in Warmer Climate


text:
Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy
Stephanie Shiau, Renate Strehlau, Jing Shen, Avy Violari, Faeezah Patel, Afaaf Liberty, Marc Foca, Shuang Wang, Mary Beth Terry, Michael T. Yin, Ashraf Coovadia, Elaine J. Abrams, Stephen M. Arpadi, Louise Kuhn
Background: Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. Setting: Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa. The mean age of children was 6.4 years at the time of measurement. HIV-infected children initiated ritonavir-boosted lopinavir-based antiretroviral therapy before 2 years of age and had been on continuous antiretroviral therapy until biomarker measurement. Methods: Telomere length was determined using multiplex quantitative polymerase chain reaction. DNAm was measured using the Illumina 450K array and DNAm age was calculated as the acceleration residual from regressing DNAm age on chronological age. Results: Telomere length (ln[Kb/genome]) was shorter in HIV-infected children compared with HUU children (4.14 ± 0.85 vs. 4.53 ± 0.79, P = 0.038) and in HEU children compared with HUU children (4.05 ± 0.74 vs. 4.53 ± 0.79, P = 0.023). Age acceleration residual based on DNAm levels was not different between HIV-infected (-0.003 ± 2.95), HEU (0.038 ± 2.39), and HUU (0.18 ± 2.49) children in unadjusted analysis and after adjustment for cell type proportions. Conclusions: Unlike reports of accelerated DNAm age in HIV-infected adults, there was no evidence of accelerated biological aging by DNAm levels in this cohort of early-treated HIV-infected children. By contrast, absolute telomere length was shorter in HIV-infected and HEU children compared with HUU children, but did not differ between HIV-infected and HEU children.
Journal of Acquired Immune Deficiency Syndromes
https://doi.org/10.1097/QAI.0000000000001714
Published - Aug 15 2018
age acceleration
biomarkers of aging
telomere length
10.1097/QAI.0000000000001714
Dive into the research topics of 'Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy'. Together they form a unique fingerprint.
HIV Medicine & Life Sciences 100%
DNA Methylation Medicine & Life Sciences 45%
Telomere Medicine & Life Sciences 29%
Acceleration Medicine & Life Sciences 12%
Lopinavir Medicine & Life Sciences 9%
Shiau, S., Strehlau, R., Shen, J., Violari, A., Patel, F., Liberty, A., Foca, M., Wang, S., Terry, M. B., Yin, M. T., Coovadia, A., Abrams, E. J., Arpadi, S. M., & Kuhn, L. (2018). Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 78(5), 549-556. https://doi.org/10.1097/QAI.0000000000001714
Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy. / Shiau, Stephanie; Strehlau, Renate; Shen, Jing et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 78, No. 5, 15.08.2018, p. 549-556.
Shiau, S, Strehlau, R, Shen, J, Violari, A, Patel, F, Liberty, A, Foca, M, Wang, S, Terry, MB, Yin, MT, Coovadia, A, Abrams, EJ, Arpadi, SM & Kuhn, L 2018, 'Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy', Journal of Acquired Immune Deficiency Syndromes, vol. 78, no. 5, pp. 549-556. https://doi.org/10.1097/QAI.0000000000001714
Shiau S, Strehlau R, Shen J, Violari A, Patel F, Liberty A et al. Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes. 2018 Aug 15;78(5):549-556. doi: 10.1097/QAI.0000000000001714
Shiau, Stephanie ; Strehlau, Renate ; Shen, Jing et al. / Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy. In: Journal of Acquired Immune Deficiency Syndromes. 2018 ; Vol. 78, No. 5. pp. 549-556.
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title = "Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy",
abstract = "Background: Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. Setting: Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa. The mean age of children was 6.4 years at the time of measurement. HIV-infected children initiated ritonavir-boosted lopinavir-based antiretroviral therapy before 2 years of age and had been on continuous antiretroviral therapy until biomarker measurement. Methods: Telomere length was determined using multiplex quantitative polymerase chain reaction. DNAm was measured using the Illumina 450K array and DNAm age was calculated as the acceleration residual from regressing DNAm age on chronological age. Results: Telomere length (ln[Kb/genome]) was shorter in HIV-infected children compared with HUU children (4.14 ± 0.85 vs. 4.53 ± 0.79, P = 0.038) and in HEU children compared with HUU children (4.05 ± 0.74 vs. 4.53 ± 0.79, P = 0.023). Age acceleration residual based on DNAm levels was not different between HIV-infected (-0.003 ± 2.95), HEU (0.038 ± 2.39), and HUU (0.18 ± 2.49) children in unadjusted analysis and after adjustment for cell type proportions. Conclusions: Unlike reports of accelerated DNAm age in HIV-infected adults, there was no evidence of accelerated biological aging by DNAm levels in this cohort of early-treated HIV-infected children. By contrast, absolute telomere length was shorter in HIV-infected and HEU children compared with HUU children, but did not differ between HIV-infected and HEU children.",
keywords = "DNA methylation, age acceleration, aging, biomarkers of aging, telomere length",
author = "Stephanie Shiau and Renate Strehlau and Jing Shen and Avy Violari and Faeezah Patel and Afaaf Liberty and Marc Foca and Shuang Wang and Terry, {Mary Beth} and Yin, {Michael T.} and Ashraf Coovadia and Abrams, {Elaine J.} and Arpadi, {Stephen M.} and Louise Kuhn",
note = "Funding Information: Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 073977, HD 073952). Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
doi = "10.1097/QAI.0000000000001714",
journal = "Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology",
T1 - Biomarkers of aging in HIV-infected children on suppressive antiretroviral therapy
AU - Shiau, Stephanie
AU - Strehlau, Renate
AU - Shen, Jing
AU - Violari, Avy
AU - Patel, Faeezah
AU - Liberty, Afaaf
AU - Foca, Marc
AU - Wang, Shuang
AU - Terry, Mary Beth
AU - Yin, Michael T.
AU - Coovadia, Ashraf
AU - Abrams, Elaine J.
AU - Arpadi, Stephen M.
AU - Kuhn, Louise
N1 - Funding Information: Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 073977, HD 073952). Publisher Copyright: © 2018 Wolters Kluwer Health, Inc. All rights reserved.
N2 - Background: Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. Setting: Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa. The mean age of children was 6.4 years at the time of measurement. HIV-infected children initiated ritonavir-boosted lopinavir-based antiretroviral therapy before 2 years of age and had been on continuous antiretroviral therapy until biomarker measurement. Methods: Telomere length was determined using multiplex quantitative polymerase chain reaction. DNAm was measured using the Illumina 450K array and DNAm age was calculated as the acceleration residual from regressing DNAm age on chronological age. Results: Telomere length (ln[Kb/genome]) was shorter in HIV-infected children compared with HUU children (4.14 ± 0.85 vs. 4.53 ± 0.79, P = 0.038) and in HEU children compared with HUU children (4.05 ± 0.74 vs. 4.53 ± 0.79, P = 0.023). Age acceleration residual based on DNAm levels was not different between HIV-infected (-0.003 ± 2.95), HEU (0.038 ± 2.39), and HUU (0.18 ± 2.49) children in unadjusted analysis and after adjustment for cell type proportions. Conclusions: Unlike reports of accelerated DNAm age in HIV-infected adults, there was no evidence of accelerated biological aging by DNAm levels in this cohort of early-treated HIV-infected children. By contrast, absolute telomere length was shorter in HIV-infected and HEU children compared with HUU children, but did not differ between HIV-infected and HEU children.
AB - Background: Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. Setting: Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa. The mean age of children was 6.4 years at the time of measurement. HIV-infected children initiated ritonavir-boosted lopinavir-based antiretroviral therapy before 2 years of age and had been on continuous antiretroviral therapy until biomarker measurement. Methods: Telomere length was determined using multiplex quantitative polymerase chain reaction. DNAm was measured using the Illumina 450K array and DNAm age was calculated as the acceleration residual from regressing DNAm age on chronological age. Results: Telomere length (ln[Kb/genome]) was shorter in HIV-infected children compared with HUU children (4.14 ± 0.85 vs. 4.53 ± 0.79, P = 0.038) and in HEU children compared with HUU children (4.05 ± 0.74 vs. 4.53 ± 0.79, P = 0.023). Age acceleration residual based on DNAm levels was not different between HIV-infected (-0.003 ± 2.95), HEU (0.038 ± 2.39), and HUU (0.18 ± 2.49) children in unadjusted analysis and after adjustment for cell type proportions. Conclusions: Unlike reports of accelerated DNAm age in HIV-infected adults, there was no evidence of accelerated biological aging by DNAm levels in this cohort of early-treated HIV-infected children. By contrast, absolute telomere length was shorter in HIV-infected and HEU children compared with HUU children, but did not differ between HIV-infected and HEU children.
KW - age acceleration
KW - biomarkers of aging
KW - telomere length
U2 - 10.1097/QAI.0000000000001714
DO - 10.1097/QAI.0000000000001714
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology


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