Inflammation is considered to are likely involved in the pathogenesis of major adverse cardiovascular events (MACE). subjects SLC7A7 who had the highest hs-CRP levels (> 0.21 mg/dL) compared to subject matter who had the lowest hs-CRP levels (< 0.08 mg/dL) after adjusting for age regular physical activity current smoking and duration of diabetes. The present results show that high hs-CRP levels can act as a AMG 208 predictor for the MACE event in Korean individuals with type 2 diabetes. Keywords: C-Reactive protein Diabetes Mellitus Type 2 Cardiovascular Diseases Hazard Ratio Intro The presence of diabetes is an self-employed risk element for atherosclerosis. Endothelial dysfunction oxidative stress and low-grade swelling are major features in the pathophysiology of this disease (1). It has been demonstrated that atherosclerosis in individuals with diabetes mellitus (DM) can lead to acute coronary artery disease ischemic cerebral disease and peripheral arterial disease (2). Because atherosclerosis is an inflammatory process several plasma markers of swelling have been evaluated as potential tools for the prediction of risk for cardiovascular disease (3). For example a high serum level of high-sensitivity C-reactive protein (hs-CRP) a marker of systemic swelling and a mediator of atherosclerotic disease has been correlated with an increased risk for cardiovascular disease (4-6). Although it is generally approved that hs-CRP levels can act as a predictor for cardiovascular disease in nondiabetic individuals there is a relative lack of data concerning the usefulness of hs-CRP levels when predicting the event of cardiovascular diseases in Asian type 2 diabetic patients. Thus the objective of this study was to clarify the self-employed clinical value of hs-CRP levels AMG 208 in the event of major adverse cardiovascular event (MACE) in Korean type 2 diabetics. MATERIALS AND Strategies Participants and research style A retrospective cohort research was conducted regarding 2 452 sufferers between 30-70 yr old with type 2 diabetes who had been maintained in the Endocrinology Section of Kwandong School Myongji Medical center Goyang Korea. Between January 2004 and Dec 2007 during medical center visits before the occurrence of MACE Serum hs-CRP amounts were measured. After careful background acquiring and physical evaluation 388 subjects had been excluded for the next reasons: prior cardiovascular AMG 208 illnesses type 1 diabetes being pregnant breast feeding severe an infection or chronic inflammatory disease (higher or lower respiratory an infection urinary tract AMG 208 illness acute gastrointestinal illness inflammatory bowel disease osteoarthritis rheumatoid arthritis chronic hepatitis gout and bronchial asthma) or high baseline hs-CRP levels (> 1 mg/dL) (7). MACE event was recognized using an electronic medical record system in the remaining 2 64 subjects. All subjects were contacted by telephone to confirm the event of MACE. If the individuals were confirmed with MACE but experienced moved to another hospital the relevant hospital was contacted so that data could be collected. The event and non-occurrence of MACE were confirmed in 1 766 of the 2 2 64 subjects. The mean follow-up period was 55.5 (20-92) months. Baseline measurements and meanings Blood sampling and hemodynamic measurements were performed on all individuals. Levels of hs-CRP were measured using a high-sensitivity assay (turbidity immune assay Toshiba Tokyo) having a detection limit of 0.01 mg/dL. DM was defined as a fasting blood sugar focus of ≥ 126 mg/dL or AMG 208 as getting anti-hyperglycemic medications. Body mass index (BMI) was computed by fat in kilograms divided by square of elevation in meters. Elevation fat and plasma degrees of hs-CRP fasting blood sugar HbA1c total cholesterol triglycerides and high-density lipoprotein (HDL)-cholesterol had been measured concurrently. LDL-C was AMG 208 approximated using the formula produced by Friedewald et al. (8) Regular exercise was thought as over 150 min of workout weekly. Myocardial infarction (MI) was described based on the guidelines from the American Heart Association/American University of Cardiology and included raised cardiac enzymes and particular electrocardiogram adjustments (9). Percutaneous coronary involvement (PCI) was thought as.
The relative function of Btk-dependent B-cell receptor (BCR) signaling in the induction of antipolysaccharide (anti-PS) and antiprotein immunoglobulin (Ig) responses for an intact extracellular bacterium in vivo is unidentified. as the existence of a compensatory Toll-like-receptor-mediated signaling pathway triggered in response to intact bacterial pathogens naturally. Bruton's tyrosine kinase (Btk) performs a key function in B-cell receptor (BCR)-mediated sign transduction (3). Btk is crucial for the standard advancement of B-1 also to a lesser level B-2 B cells. Hence, CBA/N ((6, 34) and Btk?/? (15) mice also display marked flaws in Ig induction in response to soluble T-cell-independent type 2 (TI-2) antigens (e.g., polysaccharides). As opposed to soluble TI-2 antigens, the TI-1 antigens trinitrophenol (TNP)-lipopolysaccharide and TNP-elicit regular immunoglobulin M (IgM) and IgG2 although decreased IgG3 replies in mice (24, 38), probably reflecting the adjuvant aftereffect of the linked Toll-like receptor (TLR) activity intrinsic towards the TI-1 however, not TI-2 antigen. Ig replies to T-cell-dependent (TD) antigen, in accordance with those to TI-2 antigen, are and much less severely affected in or Btk variously?/? mice, with major replies more faulty than those pursuing supplementary immunization (4, 13, 15, 26, 33). Even so, Btk seems to work as a BCR sign threshold modulator instead of as an important element of the BCR signaling pathway (32). Hence, B cells can react to particulate TI-2 antigens, such as for example TNP-sephadex or TNP-polyacrylamide (23). Additionally, Troxacitabine faulty TI-2 replies in mice could be corrected by coimmunization using a TLR agonist, such as for example 8-mercaptoguanosine (1, 21). Finally, TI-2 replies in mice could be reconstituted through provision of T-cell help (7 partly, 18). Defective humoral immune system replies in or Btk?/? mice could derive from a combined mix of faulty B-cell subset advancement and lack of Btk-mediated BCR signaling in the B cells that can be found. In this respect, mice getting one allele of the murine Btk transgene powered with the Ig large string promoter and enhancer and expressing 25% of wild-type endogenous degrees of Btk restore splenic B-2 cell advancement to wild-type amounts and have a far more modest reduction in peritoneal B-1a cells than mice (31). Even so, these mice still possess faulty BCR signaling and weaker Ig replies towards the Troxacitabine soluble TI-2 antigen TNP-Ficoll than wild-type mice. Essentially equivalent observations were made out of mice formulated with a transgene encoding the antiapoptotic proteins Bcl-2 (43). Since B-1 cells usually do not take part in the TNP-Ficoll response (10), these data highly suggest a primary function for Btk-dependent BCR signaling in Ig replies to soluble TI-2 antigens. The last mentioned studies didn't evaluate Ig replies to soluble TD antigens, which are reduced also, albeit less significantly, in mice. The research talked about above reveal that Ig replies collectively, especially to isolated polysaccharide (PS) antigens in or Btk?/? mice, may differ dependant on the existence or lack of adjuvant significantly, T-cell help, and/or antigen particulation as well as the known degree of recovery of B-cell subset advancement. In this respect, unchanged bacterial pathogens coexpress proteins and PS antigens and TLR ligands within a particulate framework. Additionally, we previously confirmed that IgG anti-PS and antiprotein replies to unchanged were both influenced by Compact disc4+ T-cell help, B7-reliant costimulation, and Compact disc40-Compact disc40 ligand connections (14, 44). Hence, the relative function of Btk-dependent BCR signaling in straight regulating anti-PS versus antiprotein Ig replies to an unchanged bacterium in vivo continues to be an open up and important issue. In this research we motivated PS- and protein-specific IgM and IgG replies to both unchanged and soluble TD conjugates of pneumococcal PS and proteins antigens Cdc42 in and Btklow mice. We demonstrate that Btk-dependent signaling has a larger function in rousing anti-PS considerably, versus anti-protein, replies to unchanged also to soluble pneumococcal conjugate in vivo pursuing recovery of B-cell subset advancement. The relevance of the data in the framework of anti-PS and antiprotein replies pursuing natural pneumococcal attacks in newborns (28, 37, 40, 41) is certainly talked about below. Btklow mice are Btk?/? mice holding a wild-type Btk transgene powered with the Ig large string enhancer and promoter, as referred to previously (31), and backcrossed Troxacitabine six years onto the BALB/c history. These mice exhibit 25% of endogenous degrees of the Btk proteins in splenic B cells. BALB/c mice (Jackson Labs, Club Harbor, Me personally) were utilized as handles for Btklow mice. CBA/CaHN-Btkxid/J (and Btklow mice had been enumerated, in accordance with those in wild-type mice, by movement cytometric evaluation (six mice per group; cells from each mouse analyzed individually) (Desk ?(Desk1).1). For enumeration of marginal area B (MZB) cells and follicular B (FB) cells, spleen cells had been stained with rat IgG2b, anti-mouse Compact disc21/Compact disc35-phycoerythrin (PE) (clone 7G6) and rat IgG2a, anti-mouse Compact disc23-biotin (clone B3B4) accompanied by streptavidin-PE-Texas Crimson. FB and MZB cells had been defined as Compact disc21high Compact disc23low and Compact disc21intermediate Compact disc23high, respectively. For enumeration of splenic B-1 cells, spleen cells had been stained with rat IgG2a, anti-mouse B220-PE (clone RA3-6B2) and rat IgG2a, anti-mouse Compact disc5-biotin.
Pulmonary adverse events are normal abnormalities from the usage of dasatinib in persistent myeloid leukemia. chylothorax can be an unusual pulmonary undesirable event. CASE Demonstration A 69-year-old guy with CML for 5 years shown complaining of intensifying dyspnea for approximately 5 days. He previously been treated with imatinib and nilotinib previously. Imatinib was ceased because of treatment failing while nilotinib was discontinued because of intolerable unwanted effects despite dosage reduction. He previously been on dasatinib 100 mg once for approximately 10 weeks which he appeared to tolerate very well daily. On demonstration his vital indications were stable but he remained dyspneic worse on exertion. He had diminished breath sounds and increased egophony on his right side. A chest radiograph Rabbit Polyclonal to ARFGAP3. showed a pleural effusion more prominent on his right side. His previous chest radiographs were normal. A subsequent chest computed tomography scan showed a moderate amount of fluid in his pleural space compromising the right lung without any adenopathy or lung masses (Figure 1). Thoracentesis revealed 1 L of thick milky-appearing fluid (Figure 2). Pleural fluid analysis showed a predominance of lymphocytes (90%) and a lactate dehydrogenase level of 120 U/L glucose of 157 mg/dL protein of 4.8 g/dL amylase of 39 U/L and triglycerides of 405 mg/dL. Adenosine deaminase was 15 U/L. Fungal bacterial and AFIB cultures were reported as negative. Figure 1. Chest computed tomography scan showing a moderate amount PHT-427 of fluid in the patient's pleural space compromising the right lung without any adenopathy or lung masses. Figure 2. One liter of thick milky-appearing fluid resulting from thoracentesis. Following thoracentesis the patient's dyspnea improved. A repeat chest radiograph showed no pneumothorax with improvement in his effusion. He was under observation for 24 hours prior to discharge and was advised to continue his dasatinib. He returned to our institution a few months later with similar symptoms requiring a therapeutic thoracentesis. His dasatinib dose was gradually decreased to 50 mg orally once daily but continued to lead to symptomatic pleural effusions. He was switched to bosutinib and has been tolerating therapy well without any symptoms. He continues to follow up with our oncology and pulmonary services. DISCUSSION Here we present a rare case of dasatinib-induced chylothorax in a patient with CML. The patient's history and thorough workup including a CT scan of the chest did not suggest any other possible etiology. Chylothorax typically results from disruption of the normal lymphatic flow such as insult to the thoracic duct or its tributaries causing leakage of lymphatic fluid into the thoracic cavity. Malignancy-induced thoracic duct obstruction is the leading reason behind chylothorax with most malignancies becoming lymphomas (70% which are Hodgkin lymphomas) (2 3 Generally factors behind chylothorax could be split into distressing or nontraumatic etiologies. Distressing cases may then become additional subdivided as iatrogenic or noniatrogenic (4). Iatrogenic distressing causes consist of thoracic duct harm pursuing subclavian vein catheterization and duct blockage because of central venous catheterization-related venous thrombosis (5). Noniatrogenic distressing cases consist of thoracic duct harm pursuing fracture dislocation from the backbone childbirth and penetrating stress from blade or gunshot accidental injuries (6 PHT-427 7 Nontraumatic etiologies consist of malignancy sarcoidosis retrosternal goiter amyloidosis excellent vena cava thrombosis harmless tumors congenital duct abnormalities and illnesses from the lymph vessels such as for example yellow nail symptoms lymphangioleiomyomatosis and hemangiomatosis (4). Dasatinib-induced chylothorax is definitely a uncommon yet recognized phenomenon poorly. Evidence shows that microscopic disruptions in lymphatic stations result in chylous effusions pursuing dasatinib therapy instead of macro-level traditional thoracic duct participation. Regardless of the multiple heterogenous etiologies for PHT-427 the introduction PHT-427 of chylothorax dasatinib may be the PHT-427 just drug regarded as connected with this adverse impact. The introduction of chylothorax PHT-427 during dasatinib therapy is probably not medication related. Several metastatic prostate cancer individuals receiving dasatinib therapy developed chylothorax also. Pleural fluid evaluation proven positive cytology. The entire span of chemotherapy was completed Therefore. In these individuals a significant medical response was recorded with complete quality of chyle effusion despite no modification.
April 2, 2017 Juanita Peters	PHT-427, Rabbit Polyclonal to ARFGAP3.
Background is a leading cause of invasive illness in young children causing morbidity and mortality. fluid analysis. Serotyping and antimicrobial susceptibility screening were performed on isolates from blood. Results A total of 15 confirmed instances of IPD were recognized among 135 recruited children including pneumonia (n?=?8) bacteremia (n?=?4) sepsis (n?=?2) and meningitis (n?=?1). The annual IPD incidence rate was 50.0/100 0 (95%CI 30.5 0 Incidence was 58.3/100 0 (28.8-120.1/100 0 among children aged less than 2?years and 44.4/100 0 Ponatinib (22.9-87.5/100 0 among children aged 2-4?years. Thirteen isolates were typified. The most common serotype was 19A (23.1%) that together with serotypes 1 7 and 19F accounted for 69.2% of typified isolates. Serotypes 14 23 12 and 15C were also recognized. The 7- and 13-valent pneumococcal conjugate vaccines covered respectively 30.8% and 84.6% of typified IPD cases. One isolate (serotype 15C) was penicillin-resistant and caused meningitis. Conclusions The inclusion of the 13-valent pneumococcal conjugate vaccine in immunization programs of young children might be considered to reduce incidence and morbidity of invasive pneumococcal disease with this surveilled human population. Background (is definitely a leading cause of bacterial pneumonia sepsis and meningitis in children and is associated with high morbidity and mortality. Recent estimates of deaths caused by in children more youthful than 5?years range from 700 0 to 1 1 million every year worldwide [1-3] having a fatality rate of around 11% (excluding pneumococcal deaths in human being immunodeficiency disease positive children) . Decrease in the number of instances of invasive pneumococcal disease (IPD) has been observed among children especially in babies both in USA and European countries which launched the hepta-valent pneumococcal conjugate vaccine (PCV) in their immunization programs [5-8] with higher reduction in USA where also reduction in IPD mortality occurred . Contemporarily an increase Ponatinib in the frequency of serotypes not included in PCV7 has been observed [7 10 above all of serotype 19A [11-15]. Additionally the circulating serotypes vary across geographical areas and may dynamically evolve resulting in different vaccine protection [2 16 17 Therefore as pneumococcal vaccines provide protection in a serotype-specific manner their appliance should be based also on the knowledge of actual circulating isolates . Prospective studies would be desired to hopefully help the health Authorities in planning efficient immunization strategies and the industry to possibly set up new updated vaccines. Indeed the World Health Organization recommends currently countries to conduct appropriate surveillance of IPD to estimate the vaccine protection rate and to monitor constantly the effect of vaccination . In Italy few local prospective RAB11FIP3 studies have been conducted in children aged less than 5?years [18-21]. There is lack of longitudinal data in Lombardy a crucial region with around 9 0 0 resident people. The main objectives of this study were to estimate the current incidence of IPD in children aged less than 5?years in North-West Lombardy Italy and to describe the serotype distribution of isolates and antimicrobial susceptibility. These data will allow to guide use of different pneumococcal conjugate vaccines Ponatinib in young children in this Ponatinib region. Methods Subjects This prospective multicenter observational study was conducted throughout the first 12-month period of an ongoing active surveillance system of IPD in young children in North-West Lombardy including the city of Milan Italy and started on September 1 2008 The study involved 10 hospitals representatively distributed in the territorial area delimited by four Reference Local Health Government bodies districts serving at the beginning of the study around 3 500 0 people and comprising 130 0 children aged less than 5?years of whom 30 0 (12 0 younger than 2?years of age) linked to the participant hospitals. All children admitted at emergency room of hospitals were frequented cautiously and assessed for eligibility. Inclusion criteria were: age at recruitment less than 5?years; being residing in the monitored area; reporting suspicion of IPD namely any clinical syndrome (e.g. pneumonia bacteremia sepsis or meningitis) and/or (in children aged ≤36 months) having at Ponatinib admission a measured rectal heat or history.
History Phosphoinositide 3-kinase (PI3Kin catecholamine-induced arrhythmia is currently unknown. unknown. Here we report that PI3Kprotects against catecholamine-induced ventricular arrhythmia by linking (PI3Kvalues were calculated with the Kruskal-Wallis nonparametric test followed by the Dunn post hoc analysis. The Fisher exact test was used to evaluate arrhythmia incidence and the log-rank test was used for survival analysis. Results PI3Kon catecholamine-induced arrhythmia ECGs were recorded in PI3Kregulates both the chronotropic and arrhythmogenic effects of myocardial (PI3Kis a negative regulator of protects against catecholamine-induced ventricular arrhythmia in both normal and failing hearts. PI3KControls and decay values cAMP decay was 30% slower in PI3K(PI3Klimits controls PDE3 and PDE4 in distinct subcellular compartments. To further prove a major involvement of PI3Kscaffold function (PI3Kin terminating Activates PDE4A Apremilast PDE4B and PDE3A via PKA Different PDE3 and PDE4 isoenzymes are expressed in the myocardium.13 The specific isoforms regulated by PI3Kwere thus analyzed in adult whole hearts. The catalytic activity of PDE4A and PDE4B was 20% lower in PI3K(Figure IXA in the online-only Data Supplement). In addition to PDE3B Rabbit Polyclonal to GPR174. 21 PDE3A activity was found to be 30% lower in PI3Kregulates membrane-bound PDE4A PDE4B and PDE3A but not PDE4D. Figure 3 Phosphoinositide 3-kinase (PI3Kmight promote PDE activation through a protein-protein interaction mechanism. Consistently Apremilast PI3Kcopurified with the long 95-kDa isoform of PDE4A and with the long 92-kDa variant of PDE4B in adult hearts (Figure 3D and 3E). Two distinct PDE3A isoforms of 97 and 106 kDa also coprecipitated with PI3K(Figure 3F). In line with cAMP PDE measurements PI3Kwas not found to interact with PDE4D (Figure IXB in the online-only Data Supplement). These data indicate that PI3Kphysically associates with and modulates PDE4A PDE4B and PDE3A but not PDE4D. PI3Kto operate PKA-mediated activation of other PDEs was investigated. Of note PDE4A PDE4B and PDE3A were part of macromolecular complexes containing PI3Ktogether with the regulatory and catalytic subunits of PKA (Figure 4A-4C). In isolated cardiomyocytes the PKA inhibitor Myr-PKI (5 (PI3Kthat cannot bind PKA (PI3K(PI3Kand PKA catalytic … Figure 5 A protein kinase A (PKA)-anchoring defective phosphoinositide 3-kinase (PI3Kis a multifunctional A-kinase anchoring protein that limits on cAMP-mediated signal transduction was evaluated next. In cardiomyocytes cAMP-activated PKA modulates crucial effectors of excitation-contraction coupling such as LTCC RyR phospholamban and troponin I.4 PKA-mediated phosphorylation of the LTCC pore-forming subunit Cav1.2 was 3-fold higher in PI3Kin controlling sarcolemmal PDE4 Cav1.2 phosphorylation was significantly enhanced in PI3Kwas found to be physically associated with Cav1.2 (Figure 6B) further supporting the view that PI3Klimits (PI3Kaffects key regulators of ventricular cardiomyocyte excitability by controlling local pools of in Ca2+ homeostasis further SR Ca2+ release was analyzed in quiescent and epinephrine-treated adult cardiomyocytes (Figure 7A). Ca2+ spark frequency was not significantly different between PI3K(PI3Kprevents spontaneous Ca2+ release events after activation of (PI3Klimits in the protection against Apremilast catecholamine-induced ventricular arrhythmia. PI3Korchestrates multi-protein complexes controlling both PKA-mediated activation of PDEs (PDE3A PDE4A PDE4B) and a physiological feedback inhibition of the Cav1.2 LTCC subunit and phospholamban. The full rescue of ventricular arrhythmia with the downstream from the also influences sinoatrial node function in vivo and supports previous evidence that PI3Kincreases spontaneous pacemaker activity in isolated sinoatrial node myocytes.28 It has previously been reported that PI3Kdirectly associates with PKA and acts as an A-kinase Apremilast anchoring protein involved in the negative regulation of cardiac cAMP.19 The present study further demonstrates that PI3Korchestrates the activity of multiple PDEs including those with a major impact on cardiac function such as PDE4A PDE4B and PDE3A. This control is independent of PI3Kkinase activity and depends on protein scaffolding. Whether PI3Kregulates PDE3 or PDE4 has been a subject of debate. In whole hearts PI3Khas been shown to regulate mainly PDE3B independently of its kinase activity.21 In contrast in isolated cardiomyocytes PI3Kappears to modulate PDE4 but not PDE3 activity.18 The.
February 26, 2017 Juanita Peters	Apremilast, Rabbit Polyclonal to GPR174.


Gilblin Stalker is a common neutral minion card, from the Goblins vs Gnomes set.
Gilblin Stalker can be obtained through Goblins vs Gnomes card packs purchased online from the Battle.net shop, or through crafting.
Since it has 3 health the Gilblin Stalker can survive most AoE effects and act on your next turn. This makes it useful if you want to cast buff spells, especially on round 3 or 4.
The threat of a Stealthed 2/3 minion on the table can deter your opponent from playing high value minions like Knife Juggler or Whirling Zap-o-matic.
The gilgoblins, sometimes called gilblins, gill goblins, or water-goblins, are a species of aquatic goblin created by Hobart Grapplehammer. They were first introduced into the game with the World of Warcraft: Cataclysm expansion.
The adaptations that allow gilgoblins to survive the aquatic life has apparently drained some of their higher brain functions and their actions are guided almost entirely by greed. They are most often seen stealing things.
Gilgoblin's live in big clams, which they decorate with their new-found treasure, including cannons, cannonballs and other things.
Gilblin Stalkers are gilblins found on the shoreline of the Swamp of Sorrows in the Eastern Kingdoms. However, the art for this card appears to depict Vashj'ir.
The artwork for this card comes from the World of Warcraft Trading Card Game "Throne of the Tides" series, for the card Gilblin Trickster.
This page was last edited on 17 June 2018, at 01:33.


text:
package com.catherine.visitor;

public class ProtectedLevel implements AccessLevel {
	private AccessLevel privateLevel;

	public ProtectedLevel() {
		privateLevel = new PrivateLevel();
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	@Override
	public void showInfo(MethodHandler retrieveMethod) {
		privateLevel.showInfo(retrieveMethod);
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}

redpajama_set_name: RedPajamaGithub


Dr. Miles received her Bachelor of Science and completed medical school at Indiana University, where she received High Honors for academic achievement. Dr. Miles completed her residency in Diagnostic Radiology at Baylor University Medical Center in Dallas and in 1998, was a fellow at Susan G. Komen Breast Center at Baylor University Medical Center in Dallas. Dr. Miles is a member of Rose Imaging Specialists.


'Review' is a half-hour comedy starring Andy Daly as critic Forrest MacNeil, who does not review boring things like films, food or art. Instead, Forrest reviews the most intense experiences of life itself -- by living them. From the dangers of drug addiction to the joys of sleeping with a celebrity, Forrest reviews anything his TV audience throws at him. He fully commits to showing us what life experiences feel like, sometimes at the expense of his family and humanity in general.


text:
Working together is the key to helping Nottingham prosper, says council leader
David Mellen says the council should work with Derby City Council and our universities
Richard Tresidder
David Mellen, the leader of Nottingham City Council (Image: Nottingham Post)
In the second part of an in-depth interview with Nottingham City Council leader David Mellen, the former school teacher tells RICHARD TRESIDDER how he is having to learn on the job, and how Nottingham can start punching its weight on a national scale.
David Mellen confesses he is something of a novice when it comes to business, regeneration and economics - "an area I am really learning" - and he says working with the two universities is crucial.
"There is a huge strength and resource there we need to harness and work with in partnership because they can get to some places we can't necessarily," he said. "And we can be supportive."
The Nottingham Growth Plan of 2012 set the footpath for the city's future economic expansion. While there have been successes, Nottingham's overall economic performance has been poor and Mr Mellen says the plan must be updated.
Expansion of the tram network remains on the agenda with an extension to Clifton Pastures to serve new housing and the possibility of a route to Gedling and towards IKEA in Broxtowe borough.
More homes needed in Nottingham to stop workers moving to the suburbs, says city council leader
Issues include how Nottingham sells itself and the next step for the Creative Quarter project which has seen the beginnings of a renaissance for Sneinton Wholesale Market. He believes the CQ project could extend its influence over the whole city.
The reopening of Nottingham Castle in 2021 should be a springboard for retaining tourists in Notts for more than a day visiting Byron's house at Newstead Abbey and Southwell among other places. "Robin Hood is very important but it is not the only story," Mr Mellen adds.
East Midlands Development Agency and the Government Office for the East Midlands were scrapped by the coalition Government in 2010 - diminishing the region's identity - with the result that Nottingham has to work harder to raise its profile working with replacement bodies such as D2N2 Local Enterprise Partnership, says Mr Mellen.
The new visitor centre at Nottingham Castle
He continues: "Although local government has been starved of resources, there is money out there through other channels if we are in the right place.
"Some areas have combined authorities or a regional mayor and might be higher up the queue than we are. Without going down those routes, we need to make are ourselves more noticeable. We shouldn't be punished because we don't have a mayor."
The city, he says, must learn to bang on the doors of Whitehall in a way different from mayors and combined authorities.
"We need to become more cohesive. We have the fifth biggest LEP (Local Enterprise Partnership) in the country and we should be punching our weight. We need to get there."
Firm behind redevelopment of Nottingham Forest stadium is confident of further expansion
Mr Mellen says HS2 to Toton is vital. "We need to make sure Prime Minister Boris Johnson and co deliver in full. It would be tempting to cut cost, to take HS2 just to Birmingham and Manchester leaving out the eastern route to Leeds. We would suffer terribly for that as would Sheffield and Leeds."
The Toton hub should not be surrounded by a huge number of houses alone, warns Mr Mellen.
"Some are fine but it must have exciting work opportunities and businesses so that people will want to come there and not just because they live nearby.
"While what goes there is important. Toton has been chosen because it is between Nottingham and Derby. We need to make sure the connectivity to the city centres is right. I don't believe our tram network is the answer to Toton but it might be to other links."
A CGI of the Toton HS2 hub (Image: East Midlands Councils)
Huge developments are taking placing within the boundaries of the proposed East Midlands Development Corporation embracing the airport, Toton and Ratcliffe-on-Soar power station.
Massive warehouses are opening at Segro's East Midlands Gateway where Amazon is creating 500 jobs in a one million square foot warehouse. Workers will be recruited from the Nottingham, Derby, Leicester triangle. The city council is still examining the impact on the city, says Mr Mellen.
In the week of this interview, Mr Mellen had met the leader of Derby City Council, Chris Poulter, twice. "We recognise the cities working together is really important. If we get it right, Toton, bang in the middle, should really help the region to develop."
Few will disagree. Mr Mellen has exciting days ahead.
Staff at Nottingham hospitals taking two weeks of sick days on average every year
Government 'considering the next steps' after Islamic school told it is still not reaching standards
Sneinton
High Speed 2

redpajama_set_name: RedPajamaCommonCrawl


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module.exports = Stat;


IN a dramatic scene a man was crash-tackled to the ground and arrested by Coffs Harbour police near the CBD this afternoon.
Traffic banked up on Moonee St just after 1pm after the man was involved in a car crash.
The 32-year-old man was seen "yelling loudly" as he was restrained and arrested by police.
Police took the man into custody for a breath analysis and he is assisting police with inquiries.


Coyote sighted:Please be aware that recently coyote(s) have been spotted in Adams Farm. This is particularly worrisome due to the number of residents and animals leashed and those that use invisible fencing. If you see a coyote during the day please call animal control at 336-641-5990. If you see a coyote during the night please contact the police.
Residents are encouraged to wrap wire mesh at the base of any tree on their property which might be affected by Beaver activity. The HOA will wire mesh those trees on common area that might be affected as well.
No dumping, of any kind, in the common areas.
No Solicitation within the Adams Farm Community: Adams Farm has a policy to NOT permit solicitation anywhere on the property. Signs indicating the same are posted at all entrances.


Well that's the holiday spam over with... time to show off the new tan! I'm a sucker for a midi dress these days and this Femme Luxe Finery black ribbed mini dress just hugs all the right places...! I'm thinking I need this in another colour now too!
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Loving this off the shoulder sweater from @femmeluxefinery thank you so much.
Love this jumper from Femme Luxe Finery. I never thought red would be my colour but I think this suits me quite well.
Husband says he likes my Bruce Lee inspired outfit. I like it too cuz it's so comfy!


Previously known as Buckeye Sports, Buckeye Surf and Snow has been a front runner in the surf apparel and water sports industry since 1949. Taking its name "Buckeye" after its multitude of Ohio (the Buckeye State) visitors, the store remains a popular tourist destination. In-store, you will find a variety of brand name apparel and water/snow equipment such as wakeboards and skis. Rentals are available for jet skis, pontoon boats, fishing boats, paddleboards, kayaks, canoes, and various towables.


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text:
Warner Bros 2014 Toy Fair Licensing Summary
Warner Bros. Consumer Products Shakes Up Toy Fair Season With Humongous Licensing Programs, Including This Summer's Much-Anticipated Film Godzilla From Legendary Pictures
UNRIVALED PORTFOLIO OF NEW AND CLASSIC ENTERTAINMENT PROPERTIES TO BE SHOWCASED
American International Toy Fair
Warner Bros 2013 Licensing Summary
Warner Bros. Consumer Products Stomps onto the Show Floor at Licensing Expo 2013 in Las Vegas
Legendary Pictures' Godzilla Leads Strong Portfolio of Entertainment Properties to Be Showcased Including Films, Television, TV Classics, Animation and Super Hero Fare
Licensing Expo
Licensing Show 2013
Warner Bros. Toy Fair Licensing Summary
Warner Bros. Consumer Products Zooms into Toy Fair Season with the Debut of its Worldwide Toy Program Supporting this Summer's Highly Anticipated Film Man Of Steel
Vast Portfolio of Theatrical, Television, Animation and Super Hero Fare to be Showcased
Burbank, Calif. – January 30, 2013 – Warner Bros. Consumer Products (WBCP) zooms into this year's exciting Toy Fair season with a roster of global licensees ready to support the Studio's portfolio, led by this summer's tentpole film release Man of Steel, which will be supported by DC Comics master toy licensee Mattel, as well as many other toy partners. With an impressive lineup driven by powerhouse properties that stretch from DC Comics Super Heroes and The Hobbit Trilogy to The Big Bang Theory and Looney Tunes, WBCP and its renowned licensees are rolling out new toys and collectibles that will reach fans of all ages.
DC Super Friends
Warner Bros. Licensing Show Summary
Warner Bros. Consumer Products Lights Up Licensing International Expo 2012 With Major Content Support For Entertainment Licensing Portfolio
Man of Steel and the Two Films Based on The Hobbit Ignite Film Merchandising Opportunities
BURBANK, Calif., June 12, 2012 -- With an impressive marquee line-up - anchored by three tent-pole films, and highlighted by pop-classic favorites, diverse animated fare and the global expansion of its themed entertainment business - Warner Bros. Consumer Products (WBCP) brings unmatched content support to this year's Licensing International Expo, offering a rich portfolio of entertainment properties for fans around the world. A powerhouse roster of partners and a myriad of programs will help drive the company's licensing, merchandising and retail business in 2012 and beyond.
Looney Tunes at Licensing Show 2012
Licensing Show Set to Light Up with Looney Tunes
BURBANK, Calif., June 7, 2012 -- If you "tawt you taw a puddy tat" or you've been asking yourself "What's up, Doc!?," it might just be because the beloved characters that have made such sights and sayings part of the universal lexicon are hotter than ever. Warner Bros. Consumer Products (WBCP) is looking to turn up the heat next week in Las Vegas as it showcases a robust Looney Tunes licensing program for retailers and licensees from around the world at Licensing Show 2012.
"The Looney Tunes are everywhere right now - animation, theatrical shorts, online, video games, home video and, of course, merchandise. All of this activity and success is driving our opportunities to develop a refreshed and ever-expanding product line for fans of all ages," said Brad Globe, President of Warner Bros. Consumer Products.
Bridge Direct


Leaving the hut in darkness with only my Petzl headlamp as company to light the wasy, I trudged along the track breaking the thin crust of ice atop the snow with every footfall. It was bitterly cold as I meandered down the gentle incline towards the unseen but noisy river. My journey now aquainting me with my voiciferous neighbour, although we had different destinations and agendas. The way ahead for me was witchbum black and inspite of the channel of directed white light, I still would trip and stumble and bark my shins against unseen rocks and stumps.
As time progressed however the inky blackness of night was slowly replaced by the shadows and half light. So it was, when my watch registered a half hour of travel, the light had strengthned to the point where Mr. Petzl was thanked for his services and retired to the depths of my day pack. This coincided nicely with the end of my bush journey. There I squatted down and surveyed the options ahead. The tussock and scrub sided river stretched out a hundred or so yards ahead before taking a steep left hander out of sight, Large slips and screes savaged the upper bush on both sides rising up to steep rock formations. Immediately to my right spilled a sizeable creek which had a 30ft waterfall just visible from my position. It was this creek I decided to explore this day. Crossing the creek to the true right I battled the snow conditions to the bottom and to one side of the cascading water. The scrub and tight bush imposed it's presence, leaving only a narrow soggy at first open climb, it quickly became more rocky and icy eventually leading me to sling my rifle on my back to leave my hands free.
I stood above the waterfall, somewhat shakily and a good deal warmer. I glanced ever upwards at the increasing steep sides of the creek towering above me. I was now roughly inline with the bush edge on both sides. The open country stretched before me, dressed in tan coloured tussock , hebes and assorted alpine plants that reached far up the slopes and ended in drab grey and black precipitous rock formations. Everything generously decorated with white snow and ice.
I left the confines of the creek, and contoured away to my left skirting the bush edge. I started to flounder in drifts. When not finding those, branches that I would brush again would reward me with a neck full of snow., Looking on the bright side though , I was generally feeling grateful of my knee length gaiters, I just wish I had a pair for my neck as well !!.
A chamois buck materialised trekking out of a depression high above. He was moving in a purposeful way conveying haste to me. The way ahead for him had perhaps fifty yards of open ground leading to a prominent ridge, once over that who knows. I threw my body to the ground and quickly sought his form in the glass ware. The animal continued to pick at this and that , whilst still on the move. I was in a position that could hardly be described as benchrest , being draped over one hebe and angling by body around another. The buck was within a few strides of the ridge, he then paused and looked straight down to me. The sights quartered his shoulders and I squeezed the light trigger....thud/kabalm...the animal looked as if he was picked up by some invisible force and slammed against the hill. A few minutes later his leg was seen to twitch twice.
The long climb up to the chamois was a mixture of exhaustion and anticipation. His coat turned out to be a first class winter one, but when I turned him over, I was to find horn rot on his other side. I reached for my buck folder and proceeded to relieve him of his pelage. Too bad about the hooks, but skin and meat was still a good deal for me.


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Tickets from Aguilares to San Salvador de Jujuy
Buy tickets from Aguilares to San Salvador de Jujuy for Thursday 07/18/2019
From Aguilares
To San Salvador de Jujuy
Aguilares to San Salvador de Jujuy
Bus tickets from Aguilares to San Salvador de Jujuy are being sold from Tramat, Andesmar, El Rápido Internacional.
The bus travel from Aguilares and San Salvador de Jujuy takes approximately about 7 hours.
The distance between Aguilares to San Salvador de Jujuy is 524 kms and you can choose between the services Semi Cama, Salón Cama; dependent on the bus company you travel with (Tramat, Andesmar, El Rápido Internacional).
Information about the city Aguilares
Aguilares is a small city of Argentina. We still could not collect a lot of information about Aguilares in this language but we are working on that. If you are searching more information or bus tickets for Aguilares, we recommend you to change the language in the upper menu or perform a search for a city close by.
Information about the city San Salvador de Jujuy
San Salvador de Jujuy is a small city of Argentina. We still could not collect a lot of information about San Salvador de Jujuy in this language but we are working on that. If you are searching more information or bus tickets for San Salvador de Jujuy, we recommend you to change the language in the upper menu or perform a search for a city close by.
Images of San Salvador de Jujuy
Vídeo de San Salvador de Jujuy
San Salvador de Jujuy - 1 - https://upload.wikimedia.org/wikipedia/commons/thumb/1/14/PlazaBelgrano.JPG/1920px-PlazaBelgrano.JPG
San Salvador de Jujuy - 2 - https://upload.wikimedia.org/wikipedia/commons/a/aa/Basilica_de_San_Francisco_Jujuy.jpg


Mr. Johnson's Chinchilla & Degu Pellet Food is a natural and wholesome food which is high in fibre and helps to maintain normal digestive function and maintain dental wear. This food is a complementary diet which should be fed alongside fresh hay, greens, vegetables and fresh water.
Wheatfeed, oatfeed, grassmeal, extracted sunflower, barley, soya, vegetable fat, limestone, salt, dicalcium phosphate, verm-x herb blend.
The following guide shows the daily feed recommendations. A chinchillas & degus diet should be made up of a high proportion of fresh clean hay an essential fibre source. This should be fed along with Supreme Chinchilla & Degu food to ensure they receive a balanced diet that meets their dietary needs.
There are currently no questions for Mr. Johnson's Chinchilla & Degu Pellet Food - be the first to ask one!


text:
english по-русски lietuviškai
Home Register Log In Search Browse Top 100 Now Online Places Help
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religion: Spiritual but not religious
drinking: Light/social drinker
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education: Some College
languages: English (Native)
interests: Alternative Music, Country Music, Football, Literature, Movies, Rap Music, Travelling
I believe in in the existence of a supreme being, I love life, I believe its very simple. I'm generally a fun loving, generous fellow, I love to read and I believe in treating people fairly. That's all I can say for now... Feel free to talk to me
I am good-looking... This I know and I'm no way modest about it, the gym is my second home, I'm athletic, maybe hot too, I don know, you tell me, lol
I am looking for a honest and real woman here, no fakes, cause you'll be wasting your time, I can smell you from your your first message
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text:
The 2012 NCAA Division I Field Hockey Championship was the thirty-second women's collegiate field hockey tournament organized by the National Collegiate Athletic Association, to determine the top college field hockey team from Division I in the United States. The Princeton Tigers won their first championship, defeating the North Carolina Tar Heels in the final. The championship was played at the L.R. Hill Sports Complex on the home field of the host Old Dominion Lady Monarchs in Norfolk, Virginia.

Bracket

References

2012
Field Hockey
2012 in women's field hockey
2012 in sports in Virginia

redpajama_set_name: RedPajamaWikipedia


Leopold I (Léopold Georges Chrétien Frédéric; German: Leopold Georg Christian Friedrich; 16 December 1790 - 10 December 1865) was from 21 July 1831 the first King of the Belgians, following Belgium's independence from the Netherlands. He was the founder of the Belgian line of the House of Saxe-Coburg-Gotha. His children included Leopold II of Belgium and Empress Carlota of Mexico. He was a maternal uncle and adviser of Queen Victoria of the United Kingdom.
He was born in Coburg and died in Laeken. By birth, he was a Prince of Saxe-Coburg-Saalfeld, later a Prince of Saxe-Coburg and Gotha and Duke of Saxony.
Leopold was the youngest son of Francis, Duke of Saxe-Coburg-Saalfeld, and Countess Augusta Reuss-Ebersdorf, and later became a prince of Saxe-Coburg and Gotha after Saxe-Coburg acquired Gotha from Saxe-Gotha-Altenburg in 1826 and yielded Saalfeld to Saxe-Meiningen.
In 1795, as a mere child, Leopold was appointed colonel of the Izmaylovsky Guards Regiment in Russia. Seven years later, he became a major general. When Napoleonic troops occupied the Duchy of Saxe-Coburg in 1806 Leopold went to Paris. Emperor Napoleon I offered him the position of adjutant, but he refused. Instead, he took up a military career in the Imperial Russian Cavalry. He campaigned against Napoleon and distinguished himself at the Battle of Kulm at the head of his cuirassier division. In 1815, at the age of 25, Leopold reached the rank of lieutenant general in the Imperial Russian Army.
In Carlton House on 2 May 1816, he married Princess Charlotte of Wales, the only legitimate child of the British Prince Regent (later King George IV) and therefore second in line to the British throne, and was created a British field-marshal and Knight of the Garter. On 5 November 1817, Princess Charlotte delivered a stillborn son; she herself died the following day. Had she lived, she would have become Queen of the United Kingdom on the death of her father, and Leopold presumably would have assumed the role later taken by his nephew, Prince Albert of Saxe-Coburg and Gotha, as Prince Consort of the United Kingdom, and never been chosen to reign as King of the Belgians. Despite Charlotte's death, the Prince Regent granted Prince Leopold the British style of Royal Highness by Order in Council on 6 April 1818.
From 1828 to 1829, Leopold was involved romantically during several months with the actress Caroline Bauer, who enjoyed a striking resemblance to Charlotte. Caroline was a cousin of his advisor Christian Friedrich Freiherr von Stockmar. She came to England with her mother and took up residence at Longwood House, a few miles from Claremont House. But, by mid-1829, the liaison was over, and the actress and her mother returned to Berlin. Many years later, in memoirs published after her death, she declared that she and Leopold had engaged into a morganatic marriage and that he had bestowed upon her the title of Countess Montgomery. He would have broken this marriage when the possibility arose that he could become King of Greece. The son of Freiherr von Stockmar denied that these events ever happened, and indeed no records have been found of a civil or religious marriage or of an ennobling of the actress.
Leopold turned down the throne of Greece. After Belgium asserted its independence from the Netherlands on 4 October 1830, the Belgian National Congress considered several candidates and eventually asked Leopold to become King of the newly formed country. He was elected on 4 June, accepted, and became "King of the Belgians" on 26 June 1831. He swore allegiance to the constitution in front of the Church of Saint Jacques-sur-Coudenberg at Coudenbergh Place in Brussels on 21 July 1831. This day became the Belgian national holiday. Jules Van Praet would become his personal secretary.
Less than two weeks later, on 2 August, the Netherlands invaded Belgium. Skirmishes continued for eight years, but in 1839, the two countries signed the Treaty of London establishing Belgium's independence.
With the opening of the railway line between Brussels and Mechelen on 5 May 1835, one of King Leopold's fondest hopes - to build the first railway in continental Europe - became a reality.
In 1840, Leopold arranged the marriage of his niece, Queen Victoria, the daughter of his sister, Princess Victoria of Saxe-Coburg-Saalfeld, to his nephew, Prince Albert of Saxe-Coburg and Gotha, son of his brother, Ernest I, Duke of Saxe-Coburg and Gotha. Even before she succeeded to the throne, Leopold had been advising the then-Princess Victoria by letter, and after her accession, he was one of the great influences on her in the early days of her monarchy, although she did begin to assert her independence very early on in her reign.
In 1842, Leopold tried unsuccessfully to pass laws to regulate female and child labor. A wave of revolutions passed over Europe after the deposition of his father-in-law, King Louis-Philippe, from the French throne in 1848. Belgium remained neutral, mainly because of Leopold's diplomatic efforts.
He was the 649th Knight of the Order of the Garter in 1816, the 947th Knight of the Order of the Golden Fleece in Spain in 1835 and the 35th Grand Cross of the Order of the Tower and Sword.
On 11 October 1850, Leopold again lost a young wife, as Queen Louise-Marie died of tuberculosis at age 38.
Leopold also had two sons, George and Arthur, by a mistress, Arcadie Meyer (née Claret). George was born in 1849, and Arthur was born in 1852. At Leopold's request, in 1862 the two sons were created Freiherr von Eppinghoven by his nephew, Ernest II, Duke of Saxe-Coburg and Gotha; in 1863 Arcadie was also created Baronin von Eppinghoven.
On 10 December 1865, the King died in Laeken at the age of 74. He lies buried in the Royal Vault at the Church of Our Lady of Laeken.


HOME › Forums › Input/Output › EZIOxx › How do I set EXIO6I Analog Inputs to 0?
If I don't want to use the analog inputs, shorting them to ground will keep them at 1 but how can I set them to 0? If it is using a resistor to reduce the 12 vdc to 5 vdc what value resistor do I need?
Can you elaborate a little. Keep input 5 & 6 in digital mode (do not set Enable Analog Inputs in configuration register) in combination with setting them to GND should keep the inputs Off.
When using the EXIO6I with Indigo if the Analog inputs are unused and left floating they fill up the log with status change notices as they fluctuate between 0 & 1 even if the analog inputs are not selected. The indigo forms recommend shorting the inputs to ground but that gives a permanent 1 indication. How can I get a 0 indication?
Can it be a problem in the EZIO6I?
Every time I have seen this using Indigo the Enable Analog Inputs option is set in the Configuration Register and the Analog Trip Points have not been set. The Analog Trip Points default to 000 for Off to On and 000 for On to Off. This results in Inputs 5 & 6 cycling between Off and On as the same analog value triggers both the On and Off indications. If the Inputs were in Digital mode the Inputs would not be cycling when connected to GND.
If you have access to a PC with a PLM or PLC such that you can run the free SimpleHomeNet Utility Suite it will display the Configuration Register settings and will also allow you to set the Analog Trip point values.
The topic below yours is related to using Indigo and that user was able to set the Analog Trip Point values using Indigo. I would suggest setting the Analog Trip points for both Input 5 & 6 as I believe they are still in Analog mode.
EDIT: forgot to answer your last question; this is not a problem with the EZIO6I.
I'll switch my EZIO6I to this configuration. It is currently set up for the last user who was using an EZEye connected to the EZIO6I and Indigo. This will take a few minutes to get the test bed setup again. Would you know what revision level the firmware is at in the EZIO6I. I have a couple of 6Is and will use the one matches or is closest to the users level.
Thanks. Based on a log snippet Bob posted on our forum, it has firmware version 25.
Do you have a Mac + Indigo to try it with? If not, just try setting the configuration register to hex 0x40. He is also setting the analog trip points to 0, 0. I agree those aren't helpful / good values, but since the configuration register is 0x40 it shouldn't be doing anything with the trip points.
Using V28 revision EZIO6I with Input 5 & 6 connected to GND with both sets of Analog Trip Points set to 0, I have no Broadcast messages when Enable Analog Inputs is Off (configuration register set to 40). When I turn on Enable Analog Inputs (configuration register set to 41) I have continuous Broadcast messages because both Analog Trip points are 0. The Broadcast messages continue until I write a 40 back into the configuration register. The following is the raw PLM messages generated during the test.
Same results seen with a revision V23 EZIO6I. No Broadcast messages until Enable Analog Inputs is turned On (configuration register set to 41) and Broadcast messages stop when Enable Analog Inputs is turned Off (configuration register set to 40). The Analog Trips Points set to 0.
I do not have Indigo and I do not have a V25 EZIO6I.


text:
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Career Discovery Expo for Girls in Grades 7-12
Free events for female students to attend with their parents/guardians, which highlight a variety of career pathways for young women. Events in Chatham and Sarnia. For more information, see the images below. To register, click on one of the images.
Strike Averted: All Elementary and Secondary Schools OPEN – Monday, November 21, 2022
St. Clair Catholic has received word that a tentative agreement has been reached between the Canadian Union of Public Employees (CUPE) and the Ontario government. Although the agreement is still subject to ratification, the tentative deal means the full withdrawal
Important Information from the Chief Medical Officer of Health
November 17, 2022 Dear Ontario Parents and Caregivers, I am reaching out to you to share some important information and reminders to help protect ourselves, our families, and our children against the spread of respiratory infections. This fall, we are
CUPE in a Legal Strike Position Effective Monday, November 21, 2022 – Schools May Close to Students
Dear Parents/Guardians, The Canadian Union of Public Employees (CUPE) has notified the province and all Ontario school boards that its members will engage in a legal strike with a full withdrawal of services, beginning Monday, November 21, 2022 unless there
John Van Heck Acclaimed Chair of the Board for 2023; Trustee David Argenti Acclaimed Vice Chair
John Van Heck returns as Chair of the St. Clair Catholic District School Board for 2023, a position he has held since 2016. He was acclaimed to the position at the Inaugural Meeting of the Board for the 2022-2026 term.
UPDATE: Power Restored at Good Shepherd
UPDATE: November 15, 2022 at 10:55 a.m. Power has been restored at Good Shepherd Catholic School in Thamesville. 7:55 a.m. Good morning, Please be advised that the power is currently out at Good Shepherd Catholic School in Thamesville. The power
Board & School Programs
UPDATE – SATURDAY, NOVEMBER 12: Wallaceburg Boil Water Advisory Lifted
Chatham-Kent Public Health has rescinded a boil water advisory, which was issued for users of the Wallaceburg Water Distribution System on November 9, 2022. This means the boil water advisory for Holy Family, Christ The King and St. Elizabeth Catholic
Flags at the Catholic Education Centre and All Schools Lowered for Remembrance Day
Flags at the Catholic Education Centre and at all St. Clair Catholic schools will be lowered to half mast in honour of Remembrance Day, on Friday, November 11, 2022. "Each year in our school communities and at the CEC, we
Board & School Programs,Community Updates
Update: Boil Water Advisory Issued for Wallaceburg – November 9, 2022
UPDATED: November 9, 2022 at 1:15 PM Dear Parents/Guardians, Water services have been restored to all St. Clair Catholic schools in Wallaceburg; however, Chatham-Kent Public Health advises a boil water advisory has been issued until further notice. Holy Family, Christ
Wallaceburg Water Update
Due to a water outage in Wallaceburg, parents/guardians at Holy Family, Christ The King and St. Elizabeth Catholic schools are encouraged to pick up children at the earliest opportunity. Students who remain at school will be dismissed at the usual
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text:
Dąbrowa – przysiółek wsi Pilczyca w Polsce położony w województwie świętokrzyskim, w powiecie włoszczowskim, w gminie Kluczewsko.

W latach 1975–1998 miejscowość administracyjnie należała do województwa piotrkowskiego.

Przypisy

Pilczyca (powiat włoszczowski)


text:
'use strict';

/**
 * @fileoverview Adds export button, print, and other dynamic functionality to
 * the report.
 */

/* globals self URL Blob CustomEvent getFilenamePrefix window */

class ReportUIFeatures {
  /**
   * @param {!DOM} dom
   */
  constructor(dom) {
    /** @type {!ReportRenderer.ReportJSON} */
    this.json; // eslint-disable-line no-unused-expressions
    /** @protected {!DOM} */
    this._dom = dom;
    /** @protected {!Document} */
    this._document = this._dom.document();
    /** @private {boolean} */
    this._copyAttempt = false;
    /** @type {!Element} **/
    this.exportButton; // eslint-disable-line no-unused-expressions

    this.onMediaQueryChange = this.onMediaQueryChange.bind(this);
    this.onCopy = this.onCopy.bind(this);
    this.onExportButtonClick = this.onExportButtonClick.bind(this);
    this.onExport = this.onExport.bind(this);
    this.onKeyDown = this.onKeyDown.bind(this);
    this.printShortCutDetect = this.printShortCutDetect.bind(this);
  }

  /**
   * Adds export button, print, and other functionality to the report. The method
   * should be called whenever the report needs to be re-rendered.
   * @param {!ReportRenderer.ReportJSON} report
   */
  initFeatures(report) {
    this.json = report;
    this._setupMediaQueryListeners();
    this._setupExportButton();
    this._setUpCollapseDetailsAfterPrinting();
    this._resetUIState();
    this._document.addEventListener('keydown', this.printShortCutDetect);
    this._document.addEventListener('copy', this.onCopy);
  }

  /**
   * Fires a custom DOM event on target.
   * @param {string} name Name of the event.
   * @param {!Node=} target DOM node to fire the event on.
   * @param {*=} detail Custom data to include.
   */
  _fireEventOn(name, target = this._document, detail) {
    const event = new CustomEvent(name, detail ? {detail} : null);
    target.dispatchEvent(event);
  }

  _setupMediaQueryListeners() {
    const mediaQuery = self.matchMedia('(max-width: 600px)');
    mediaQuery.addListener(this.onMediaQueryChange);
    // Ensure the handler is called on init
    this.onMediaQueryChange(mediaQuery);
  }

  /**
   * Handle media query change events.
   * @param {!MediaQueryList} mql
   */
  onMediaQueryChange(mql) {
    const root = this._dom.find('.lh-root', this._document);
    root.classList.toggle('lh-narrow', mql.matches);
  }

  _setupExportButton() {
    this.exportButton = this._dom.find('.lh-export__button', this._document);
    this.exportButton.addEventListener('click', this.onExportButtonClick);

    const dropdown = this._dom.find('.lh-export__dropdown', this._document);
    dropdown.addEventListener('click', this.onExport);
  }

  /**
   * Handle copy events.
   * @param {!Event} e
   */
  onCopy(e) {
    // Only handle copy button presses (e.g. ignore the user copying page text).
    if (this._copyAttempt) {
      // We want to write our own data to the clipboard, not the user's text selection.
      e.preventDefault();
      e.clipboardData.setData('text/plain', JSON.stringify(this.json, null, 2));

      this._fireEventOn('lh-log', this._document, {
        cmd: 'log', msg: 'Report JSON copied to clipboard',
      });
    }

    this._copyAttempt = false;
  }

  /**
   * Copies the report JSON to the clipboard (if supported by the browser).
   * @suppress {reportUnknownTypes}
   */
  onCopyButtonClick() {
    this._fireEventOn('lh-analytics', this._document, {
      cmd: 'send',
      fields: {hitType: 'event', eventCategory: 'report', eventAction: 'copy'},
    });

    try {
      if (this._document.queryCommandSupported('copy')) {
        this._copyAttempt = true;

        // Note: In Safari 10.0.1, execCommand('copy') returns true if there's
        // a valid text selection on the page. See http://caniuse.com/#feat=clipboard.
        if (!this._document.execCommand('copy')) {
          this._copyAttempt = false; // Prevent event handler from seeing this as a copy attempt.

          this._fireEventOn('lh-log', this._document, {
            cmd: 'warn', msg: 'Your browser does not support copy to clipboard.',
          });
        }
      }
    } catch (/** @type {!Error} */ e) {
      this._copyAttempt = false;
      this._fireEventOn('lh-log', this._document, {cmd: 'log', msg: e.message});
    }
  }

  closeExportDropdown() {
    this.exportButton.classList.remove('active');
  }

  /**
   * Click handler for export button.
   * @param {!Event} e
   */
  onExportButtonClick(e) {
    e.preventDefault();
    const el = /** @type {!Element} */ (e.target);
    el.classList.toggle('active');
    this._document.addEventListener('keydown', this.onKeyDown);
  }

  /**
   * Resets the state of page before capturing the page for export.
   * When the user opens the exported HTML page, certain UI elements should
   * be in their closed state (not opened) and the templates should be unstamped.
   */
  _resetUIState() {
    this.closeExportDropdown();
    this._dom.resetTemplates();
  }

  /**
   * Handler for "export as" button.
   * @param {!Event} e
   */
  onExport(e) {
    e.preventDefault();

    const el = /** @type {!Element} */ (e.target);

    if (!el.hasAttribute('data-action')) {
      return;
    }

    switch (el.getAttribute('data-action')) {
      case 'copy':
        this.onCopyButtonClick();
        break;
      case 'print-summary':
        this.collapseAllDetails();
        this.closeExportDropdown();
        self.print();
        break;
      case 'print-expanded':
        this.expandAllDetails();
        this.closeExportDropdown();
        self.print();
        break;
      case 'save-json': {
        const jsonStr = JSON.stringify(this.json, null, 2);
        this._saveFile(new Blob([jsonStr], {type: 'application/json'}));
        break;
      }
      case 'save-html': {
        const htmlStr = this.getReportHtml();
        try {
          this._saveFile(new Blob([htmlStr], {type: 'text/html'}));
        } catch (/** @type {!Error} */ e) {
          this._fireEventOn('lh-log', this._document, {
            cmd: 'error', msg: 'Could not export as HTML. ' + e.message,
          });
        }
        break;
      }
      case 'open-viewer': {
        this.sendJsonReport();
        break;
      }
      case 'save-gist': {
        this.saveAsGist();
        break;
      }
    }

    this.closeExportDropdown();
    this._document.removeEventListener('keydown', this.onKeyDown);
  }

  /**
   * Keydown handler for the document.
   * @param {!Event} e
   */
  onKeyDown(e) {
    if (e.keyCode === 27) { // ESC
      this.closeExportDropdown();
    }
  }

  /**
   * Opens a new tab to the online viewer and sends the local page's JSON results
   * to the online viewer using postMessage.
   * @protected
   */
  sendJsonReport() {
    const VIEWER_ORIGIN = 'https://googlechrome.github.io';
    const VIEWER_URL = `${VIEWER_ORIGIN}/lighthouse/viewer/`;

    // Chrome doesn't allow us to immediately postMessage to a popup right
    // after it's created. Normally, we could also listen for the popup window's
    // load event, however it is cross-domain and won't fire. Instead, listen
    // for a message from the target app saying "I'm open".
    const json = this.json;
    window.addEventListener('message', function msgHandler(/** @type {!Event} */ e) {
      const messageEvent = /** @type {!MessageEvent<{opened: boolean}>} */ (e);
      if (messageEvent.origin !== VIEWER_ORIGIN) {
        return;
      }

      if (messageEvent.data.opened) {
        popup.postMessage({lhresults: json}, VIEWER_ORIGIN);
        window.removeEventListener('message', msgHandler);
      }
    });

    const popup = /** @type {!Window} */ (window.open(VIEWER_URL, '_blank'));
  }

  /**
   * Expands audit details when user prints via keyboard shortcut.
   * @param {!Event} e
   */
  printShortCutDetect(e) {
    if ((e.ctrlKey || e.metaKey) && e.keyCode === 80) { // Ctrl+P
      this.closeExportDropdown();
    }
  }

  /**
   * Expands all audit `<details>`.
   * Ideally, a print stylesheet could take care of this, but CSS has no way to
   * open a `<details>` element.
   */
  expandAllDetails() {
    const details = this._dom.findAll('.lh-categories details', this._document);
    details.map(detail => detail.open = true);
  }

  /**
   * Collapses all audit `<details>`.
   * open a `<details>` element.
   */
  collapseAllDetails() {
    const details = this._dom.findAll('.lh-categories details', this._document);
    details.map(detail => detail.open = false);
  }

  /**
   * Sets up listeners to collapse audit `<details>` when the user closes the
   * print dialog, all `<details>` are collapsed.
   */
  _setUpCollapseDetailsAfterPrinting() {
    // FF and IE implement these old events.
    if ('onbeforeprint' in self) {
      self.addEventListener('afterprint', this.collapseAllDetails);
    } else {
      // Note: FF implements both window.onbeforeprint and media listeners. However,
      // it doesn't matchMedia doesn't fire when matching 'print'.
      self.matchMedia('print').addListener(mql => {
        if (mql.matches) {
          this.expandAllDetails();
        } else {
          this.collapseAllDetails();
        }
      });
    }
  }

  /**
   * Returns the html that recreates this report.
   * @return {string}
   * @protected
   */
  getReportHtml() {
    this._resetUIState();
    return this._document.documentElement.outerHTML;
  }

  /**
   * Save json as a gist. Unimplemented in base UI features.
   * @protected
   */
  saveAsGist() {
    throw new Error('Cannot save as gist from base report');
  }

  /**
   * Downloads a file (blob) using a[download].
   * @param {!Blob|!File} blob The file to save.
   * @private
   */
  _saveFile(blob) {
    const filename = getFilenamePrefix({
      url: this.json.url,
      generatedTime: this.json.generatedTime,
    });

    const ext = blob.type.match('json') ? '.json' : '.html';
    const href = URL.createObjectURL(blob);

    const a = /** @type {!HTMLAnchorElement} */ (this._dom.createElement('a'));
    a.download = `${filename}${ext}`;
    a.href = href;
    this._document.body.appendChild(a); // Firefox requires anchor to be in the DOM.
    a.click();

    // cleanup.
    this._document.body.removeChild(a);
    setTimeout(_ => URL.revokeObjectURL(href), 500);
  }
}

if (typeof module !== 'undefined' && module.exports) {
  module.exports = ReportUIFeatures;
} else {
  self.ReportUIFeatures = ReportUIFeatures;
}


All such processes involve close orchestration among different systems, namely the immune system, hormonal system, and local mediators.
The role of the connective tissue as a body-wide signaling network has been recognized by the ancient cultures and has been recently revisited by authors such as Dr. Langevin.
Dr Langevin also makes the connection between the connective tissue planes and the meridians, thereby offering an explanation of the phenomena observed in daily practice when working with acupuncture points.
The role of mechanical forces on the ECM is also becoming clearer, although the exact mechanism of action is still not completely known. In the past two decades, research has determined that many cells are sensitive to mechanical forces and can change their phenotype as well as the structure of the surrounding connective tissue.
Electrical signals Szent-Györgyi used the term "bio-energetics" to refer to energy not confined in bio-molecules but emitted or absorbed directly by tissue.
In these cases, therefore, movement is encouraged to support better healing, and ultrasound or other devices may be used to simulate the piezoelectric signal.
Transmission of this piezoelectric signal is also impaired following joint injury and trauma or in diseases such as osteoarthritis.
Sports medicine has documented the effect of stretching on healing tendons and other structures.
Recent evidence suggests that stretching may even attenuate inflammatory signals in osteoarthritis joints and suggest that constant application of cyclic tensile strain (CTS) blocks IL-1 β-induced pro-inflammatory genes at the transcriptional level.
Further more, the sustained effects of mechanical signals are also reflected in their ability to induce aggrecan synthesis.
Plasticity signals..Structural change of an organism is closely related to the cell's ability to modulate its peri-cellular environment, whether in the normal process of growth, in maintaining homeostasis, or as part of a disease process.
Proteolytienzymes stimulated by tissue damage or inflammatory mediators are counteracted by anti-proteases activated by substances such as TGF-β.
Oschman also ex-amines this phenomenon in an article reviewing the role of free electrons and their antioxidant activity.
We would do well to include stretching or even aerobic exercise as part of our patients' treatment.
The need is especially great in cases of tissue damage that require remodeling, as in fractures, osteoporosis, and even tendon injury.
normal cortisol diurnal rhythm, and normal angiogenic balance.
The example of the zebra fish tail, which regenerates completely after being severed, shows that adult zebra fish have the capacity to regenerate the caudal fin, a process that is inhibited by exposure to the ubiquitous environmental contaminant 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD).
Fin re-generation is a complex process requiring precise regulation of several processes including wound healing, ECM production, revascularization, innervation, and bone formation.
TCDD, a persistent organic pesticide, directly inhibits this process.
Pulsatilla compositum are especially suitable for supporting the matrix biorhythm.
Microscopic view of the extracellular matrix of TGF-β (part of the working mechanism of Traumeel) is also of benefit.
Together with adequate movement and nutrition and restoration of sleep/wake cycles, they may ensure normal matrix plasticity and restore anabolic/catabolic cycles.
Abraham LC, Dice JF, Lee K, Kaplan DL.
Gierse H, Breul R, Faensen M, Markoll R.
broblasts form a body-wide cellular network.
Timmons JA, Jansson E, Fischer H, et al.
tion to aerobic exercise training in humans.
Carmeli E, Moas M, Lennon S, Powers SK.


Colin Meloy of the Decemberists had a special wish for all fans attending his band's sold-out show at the Fox Theater on Valentine's Day.
Hey, it could happen. Some people find romance by listening to bedroom jams spun by Barry White and R. Kelly. Others might find it in bookish lyrics about giant whales, sad orphans and military wives, always rhymed with perfect diction.
It's a safe bet that no one among the 2,800 fans in attendance at the Decemberists' sold-out show at the Fox Theatre in Oakland ever considered skipping the concert in favor of staying home to watch the "American Idol" finale.
Just got back from a long round trip up to see Britney Spears in Sacramento. Ever wonder what a music critic listens to on a roundtrip? No? Well, no matter, I'll tell you: On the way up I listened to the new live Dead set from '77 Hartford (especially killer "Sugaree") and on the way back down I listend to sports talk radio, then the Decemberists' "Hazards of Love" (by far, the best album of the year thus far). Oh, and how about those Chicago Blackhawks!
I'll spend some of my Easter morning writing up my thoughts on the Britney show. So look for that – or wait for Shay Quillen's far more eloquent write-up of Brit's show Sunday in San Jose.
Local date: May 20 at the Fox Theater in Oakland. Tickets are $35. Call 510-835-0887 or visit www.thefoxoakland.com.
The skinny: The Decemberists came to Austin as this year's model of "The Band Most Likely to Break Big." These Oregonians are already huge in the indie-pop world, but many believe their forthcoming album, "The Hazards of Love" (due in stores Tuesday), could launch the group into the mainstream. Vocalist Colin Meloy and his troupe performed "Hazards" from start to finish during its SXSW opening night showcase, and the reaction from the crowd was modest at best. The new songs were quirky, bookish and full of antiquated vernacular – all Decemberists trademarks – but the added twist, a high-concept classic-rock sound, made for a concert that was a bit less engaging than past Decembrists' gigs. It's hard to imagine many of these songs being played on the radio, which means the group probably won't become the next Death Cab for Cutie – and, just to be clear, that's not a bad thing.
Although it once served a purpose, the term "alternative rock" is nearly meaningless in 2008. It's close to being a catch-all title, one that is used to describe every new rock act from Arcade Fire to TV on the Radio.
Yet, the term _ especially its first half _ is one that could be justifiably used in the case of the Decemberists, the Portland, Ore.-reared band that thrilled a capacity crowd at the Warfield in San Francisco on Tuesday night.
The Decemberists qualify as alternative rock, in the sense that no other act comes close to sounding like they do. The same certainly can't be said about the Killers, Stone Temple Pilots, Franz Ferdinand or, basically, whatever band is currently playing on Live 105.


text:
What countries does the Nile River start?
Esther Fleming August 14, 2020
What 11 countries does the River Nile flow through?
How many countries does River Nile pass through?
Where does the Nile River start and end?
Are there any other names for the Nile River?
Where does the White Nile and the Blue Nile start?
Which is the most important city on the Nile River?
The Blue Nile begins at Lake Tana in Ethiopia and flows into Sudan from the southeast. The two rivers meet just north of the Sudanese capital of Khartoum….
The river in Uganda
Countries Egypt, Sudan, South Sudan, Ethiopia, Uganda, Congo, Kenya, Tanzania, Rwanda, Burundi
We believe in the free flow of information The Nile river basin contains over 10% of Africa's landmass, in 11 countries: Ethiopia, Sudan, South Sudan, Egypt, Rwanda, Tanzania, Uganda, Burundi, the Democratic Republic of Congo, Eritrea and Kenya.
eleven countries
pdf Major Subbasins Popular. The Nile River flows through eleven countries (Burundi, DRCongo, Egypt, Ethiopia, Eritrea, Kenya, Rwanda, South Sudan,Sudan, Tanzania, and Uganda).
Vocabulary The Nile River flows from south to north through eastern Africa. It begins in the rivers that flow into Lake Victoria (located in modern-day Uganda, Tanzania, and Kenya), and empties into the Mediterranean Sea more than 6,600 kilometers (4,100 miles) to the north, making it one of the longest river in the world.
Other names include Aur, Atbara, The White Nile, Yellow Nile, and the Blue Nile. The river may only be a natural water source; however, no river in history has caused so many political wrangles.
Which country does the Nile River start? The White Nile, which is the longer of the two, begins at Lake Victoria in Tanzania and flows north until it reaches Khartoum, Sudan, where it converges with the Blue Nile. The Blue Nile begins near Lake Tana in Ethiopia. The Nile River empties into the Mediterranean Sea in northern Egypt.
Currently, major towns in Egypt are located along its bank. The most important being Cairo, the Capital City. The Nile Bridge is the most famous attraction on the river. The Nile is governed by a pre-colonial Agreement.
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Founded in 1990, Building Research Establishment's Environmental Assessment Method (BREEAM) was the world's first process to assess building sustainability. BREEAM addresses and assesses multiple lifecycle stages, including new construction, refurbishment and in-use structures. BREEAM is the world's leading sustainability assessment standard for buildings, master-planned projects and infrastructure.


How can we believe in a country where liberal Zionism is dead?
At the very end of this Parliament, Conservative MP Charles Walker – chairman of the Commons procedure committee – railed against a bid by his own party's front bench to introduce secret ballots to elect Mr Speaker.
Everyone knew this was a "grubby" and vindictive attempt to get at John Bercow, who was hated by the government because he was effective in giving backbenchers a voice.
I think we in the progressive/liberal wings of British – and probably world – Jewry have been played for fools.
We always come running when there's a crisis involving Israel – and when, how convenient, isn't there? And so it was when Yachad, the New Israel Fund, the Reform and Liberal movements as well as their and other progressive youth movements attended We Believe In Israel.
How can we believe in a country where not only are our rabbis not allowed to conduct life-cycle ceremonies such as marriages or britot, but if they do conduct weddings, they and the happy couple could face criminal prosecution?
Imagine the gnashing of teeth if Britain or France or Germany decided that rabbis couldn't conduct Jewish wedding ceremonies. We'd all be up in arms. Justifiably. But when it comes to Israel? Nada. Our Judaism isn't even considered Jewish enough for our rabbis to conduct conversions. That's in the national homeland of the Jewish people – which apparently doesn't accept the Judaism of the majority of world Jewry.
Even at Judaism's most holy prayer site, the Western Wall, we are basically relegated to out of sight and out of mind with a little bit of the Kotel at our disposal.
Heaven forfend the main plaza would be split three ways. That, apparently would offend the sensibilities of the Orthodox. Progressives, it seems, have no sensibilities worth offending.
How can we believe in a country where the prime minister, in a desperate bid to cling on to power, urges his supporters to vote because "the Arabs are voting in droves and the rule of the right is in danger"?
What do you think the communal reaction here would be if David Cameron, come 7 May, urged his supporters out to vote because "the Jews are voting in droves in Golders Green and Hendon and my government is in danger".
Anti-Semitism, innit? You betcha, it is.
Even before We Believe In Israel, there have been instances which must have given every liberal or progressive Jew pause.
Take Israel's offensive in Gaza in November 2012. Communal organisations, including MRJ, of which I am a member, and even the Liberal Movement, wrote a letter in support of the Israeli government.
Not in support of the Israeli people in their time of need, mind you. That would be understandable, but in support of – and expressing pride in – the Israeli military and political leadership. What was that all about?
I can understand the right of the community accepting blindly and parroting the Israeli line.
They believe that only the Jews have national rights to Israel (and the Occupied Palestinian Territories). They also believe that documents framed by diplomats in the dying days of European empire and colonialism have any relevance today. After all, Balfour, Sykes-Picot and San Remo were bids to carve up the Middle East for France and Britain – not for the indigenous populations.
But liberals and progressives who believe in inclusion and not exceptionalism? For me, this does not compute.
And there's the rub. The progressives appear to me to be scared. Not of anti-Semitism, but of what the "hush… schtill… don't rock the boat" organisations might say and do.
Some in our community always want to see Israel as the "scapegoat" being victimised by the British media, too, because it means that they don't have to think too hard about why Israel is criticised.
It's always someone else's fault (and in that they are no different from those who uncritically support the Palestinians).
Unfortunately, and I write this with great sadness, this uncritical attitude has trickled down to the supposedly more progressive elements in the community.
It means that Israel is being indulged both publicly and privately – and no one appears to have the courage to speak truth to power.


text:
package com.defensio.requests;

import java.util.List;

public class ReportFalseNegativesRequest extends DefensioRequest {

	private String _ownerUrl = null;
	private List _signatures = null;

	public ReportFalseNegativesRequest() {
		setAction("report-false-negatives");
	}

	public String getOwnerUrl() {
		return _ownerUrl;
	}
	public void setOwnerUrl(String ownerUrl) {
		_ownerUrl = ownerUrl;
	}
	public List getSignatures() {
		return _signatures;
	}
	public void setSignatures(List signatures) {
		_signatures = signatures;
	}
}


We have the perfect gift for Mother's Day or just for yourself!
Come out for a night of fun with local flower farmers, Field + Forage, and learn how to make a beautiful macrame plant hanger. Field + Forage will supply everything, even a cute little plant, and give hands on help and teaching so you leave with an adorable hanger ready to adorn your home. Field + Forage looks forward to teaching several macrame knotting techniques, so you can make future beautiful creations for your home and gifts!


Objective: To determine the feasibility and safety of aripiprazole augmentation for incomplete response to sequential selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) pharmacotherapy in late-life depression.
Method: This study was a 12-week, open-label pilot study of 24 patients (recruited from June 1, 2006, to June 1, 2007) aged 65 years and above (mean, 73.9 years) diagnosed with major depressive disorder (MDD) (according to DSM-IV) who responded partially (17-item Hamilton Rating Scale for Depression [HAM-D-17] score of 11 to 15) or not at all (HAM-D score >15) to a 16-week trial of escitalopram (up to 20 mg/day), followed by either duloxetine (up to 120 mg/day) or venlafaxine (up to 225 mg/day) for 12 weeks. Subjects received 2.5 to 15 mg per day of adjunctive aripiprazole (mean dose, 9.0 mg/day) for 12 weeks. The criterion for remission during treatment with aripiprazole was a HAM-D score 10 for 2 consecutive weeks.
Conclusion: In older adults with MDD with incomplete response to SSRI and SNRI pharmacotherapy, aripiprazole was well tolerated, and symptoms of depression improved significantly during treatment with aripiprazole. A randomized, double-blind, placebo-controlled trial of adjunctive aripiprazole for incomplete response in late-life depression is warranted to further evaluate benefit and risk.