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Declaratory Act
Declaratory Act of 1765
The Declaratory Act was passed along with the repeal of the Stamp Act in March, 1766 to assert Parliament's authority to rule over the American colonies. Members of Parliament knew they had to repeal the Stamp Act because it had brought the British economy to a standstill after the Americans boycotted British goods.
Many members were reluctant to repeal the Stamp Act though, because they thought it would make Britain look weak and would send the message that all people had to do was protest and riot against Parliament and they would back down to their demands.
The remedy was the Declaratory Act, which stated that Parliament had "full power and authority to make laws and statutes of sufficient force and validity to bind the colonies and people of America, subjects of the crown of Great Britain, in all cases whatsoever." Learn more about the Declaratory Act below.
Background of the Declaratory Act
Colonists sacking the home of Lt. Gov. Thomas Hutchinson
The Stamp Act was passed by the British Parliament on March 22, 1765 and was set to go into effect on November 1st of that year. To the surprise of Parliament, the colonists rose up in one accord and protested against its implementation.
Stamp distributors were harassed, marched through the streets and forced to sign statements renouncing the Act. Some had their homes and personal property destroyed or damaged. Other officials and Royal Governors were threatened at gunpoint. In Massachusetts, the Lieutenant Governor had his house burned to the ground. Newspapers and prominent citizens published articles criticizing Parliament for taxing them without their consent. They challenged Parliament's right to make any laws governing them at all, since they were not represented in Parliament.
Many prominent merchants signed non-importation agreements, meaning they would not import British made goods, until the Stamp Act was repealed. This turned out to be the most impactful protest of the colonists because it brought the British economy to a standstill.
Merchants and manufacturers in Britain began to suffer immediately from the boycott. Many had ships full of cargo intended for the colonies that could not sail, waiting in British ports. Their bills began to go unpaid and tens of thousands of workers were let go in Britain's manufacturing towns, such as London, Bristol, Liverpool and Manchester.
These British merchants and workers began pressing their members of Parliament to repeal the Stamp Act so they could go back to work and pay their bills. On December 6, 1765, the Committee of Merchants in London sent a letter to the mayor of London stating that many businesses would soon be forced to shut down if the Stamp Act was not repealed. You can read this Letter from the London Merchants Urging Repeal of the Stamp Act here. Very soon, a strong coalition rose up in Parliament to see the repeal through.
Prime Minister Charles Rockingham
Prime Minister George Grenville, who had championed the Sugar Act and the Stamp Act, fell out of power and was replaced in July, 1765. Charles Watson-Wentworth, the Marquis of Rockingham, succeeded Grenville. Lord Rockingham was much more favorable to the Americans and he wanted to see the Stamp Act repealed himself. Rockingham and his assistant, Edmund Burke began to organize resistance to the Stamp Act by encouraging merchants to press their members of Parliament to repeal the law.
After the Christmas break, Parliament reconvened on January 14, 1766 and Rockingham presented his plan for repeal. Some wanted to simply amend the Stamp Act to make it more palatable to the colonists. Others wanted a complete repeal. Some wanted no repeal at all because they thought it would make Parliament look weak.
William Pitt made a famous speech defending the colonists. In it, he agreed that Parliament was "sovereign and supreme, in every circumstance of government and legislature whatsoever," but he also said it was his "opinion that this Kingdom has no right to lay a tax upon the colonies." He said that the colonies acknowledged the King's "authority in all things, with the sole exception that you shall not take their money out of their pockets without their consent."
This speech made Pitt into one of Parliament's great defenders of the colonists. You can read his speech, called In Defense of the Colonies here.
Lord Rockingham even invited Ben Franklin, who was living in London at the time, to speak to Parliament about the values and policies of the American colonies. Franklin was there representing several colonies to the Crown and was already a famous inventor and writer by this time. Many scholars believe Franklin's frank discussion with Parliament opened the eyes of many members to realize they were not going to win this fight. You can read the transcript of the Examination of Benjamin Franklin before the House of Commons here.
Parliament's ideas vs the colonists' ideas
As the debate raged on through January and February, most members began to see that the repeal of the Stamp Act was the only way to solve the present crisis and get the economy moving again. They realized the Americans would not submit to the stamp taxes and would continue their boycott, stalling the entire British economy, until the Act was repealed.
They had serious disagreements with two of the Americans' main arguments though. First, the Americans believed that Parliament had no right to tax them. The Americans, according to the testimony of Ben Franklin, made a distinction between internal taxes, which meant taxes on daily activities solely inside the colonies, and external taxes, which meant taxes on imported items from nations outside the colonies.
Franklin showed Parliament that the Americans would agree to external taxes, but not to internal taxes and the only reason they would agree to external taxes was because royal officials were necessary to monitor imports and exports and it was necessary to have funds to support them. Any other taxes though, especially those meant solely to raise revenue to fund various activities of Parliament, were viewed as evil, illegal and unconstitutional.
The second policy of the Americans that Parliament disagreed with was their assertion that Parliament had no authority whatsoever to make any law of any kind regarding the colonies! The colonists relied on the age old English tradition that it was unjust for a governing body to make laws over people that had no representation in that lawmaking body. The colonists had no representatives in Parliament and therefore, in their minds, Parliament had no legal right to make laws for them. Instead, each colony had its own elected legislature and those elected legislatures were the proper place to make laws for the colonies.
Many members of Parliament were incredulous at this idea. They viewed Parliament as the supreme authority and its laws as binding on everyone in the Empire. They believed that if the Stamp Act were to actually be repealed, it would undermine Parliament's authority. It would make Parliament look weak and would send the message that all a person had to do was protest and riot to make Parliament change its mind. It would make the people supreme, instead of Parliament!
The solution - the Declaratory Act
Many members threatened that they would not sign the Stamp Act repeal unless some statement affirming Parliament's sovereignty accompanied it. This would make it appear that Parliament merely perceived that this particular law was a bad law, but would show that they were not agreeing with the American ideas that they had no authority to tax or make laws regarding the colonies.
The Declaratory Act, also called American Colonies Act 1766, was the result of this compromise. A large group of members agreed to sign the repeal bill, if a statement affirming Parliament's authority to make laws for the colonies was passed along with it. Lord Rockingham accepted the deal in order to get the Stamp Act repealed, even though he didn't necessarily agree with the ideas in the Declaratory Act.
Stamp Act Repeal Announcement London Gazette
In the end, both houses of Parliament voted for the repeal and the Declaratory Act was simply attached by a voice vote, not even with an official count. The Stamp Act was repealed and the Declaratory Act was passed by Parliament on March 17, 1766. King George III came to Parliament the following day and signed them both into law. Since the two bills were passed together, they became known as the "Twin Brothers."
The Declaratory Act proclaimed three main things:
That the colonial assemblies did not have the sole and exclusive right of imposing duties and taxes upon their colonial subjects.
That Parliament had "full power and authority to make laws and statutes of sufficient force and validity to bind the colonies and people of America... in all cases whatsoever," just as it had in Britain.
And that any laws or resolutions made by the colonial assemblies denying Parliament's rightful authority to make laws governing them were repealed and made utterly null and void.
Results of the Declaratory Act
Obelisk erected in Boston for the Repeal of the Stamp Act celebrations
Of course, once word arrived in the colonies that the Stamp Act was repealed, the colonists rejoiced up and down the seaboard. Celebrations were held, bonfires were lit, merchants agreed to buy British goods once again. A statue of King George was even erected on the Bowling Green in New York City. In all the celebration, little notice was paid to the Declaratory Act. They had fought a good fight and felt satisfied that Britain had learned its lesson.
A few colonial leaders, however, though they were joyful at the Stamp Act's repeal, saw the Declaratory Act as the ominous sign that it was. Even though the colonists had won this battle, Parliament still was asserting its right to tax them and make binding laws upon them for any reason. It seemed that more unreasonable laws and taxes might be soon upon them.
Patriot leaders such as John Adams, Samuel Adams and Patrick Henry saw trouble coming as a result of the Declaratory Act as well. The Declaratory Act was taken nearly word-for-word from the Irish Declaratory Act of 1719, which had removed Ireland's ability to govern itself as well and put it into a position of servitude to Parliament.
Thomas Jefferson later wrote that,
"By one act they have suspended the powers of one American legislature and by another have declared they may legislate for us themselves in all cases whatsoever. These two acts alone form a basis broad enough whereon to erect a despotism of unlimited extent."
The fears of these leaders were soon to be realized when a set of acts known as the Townshend Acts were passed in 1767. This series of five acts was designed to raise revenue for the salaries of colonial officials, to enforce trade laws on the colonies and to punish the colony of New York for disobeying the Quartering Act of 1765. The colonists realized that the victory in having the Stamp Act repealed was lost and that Parliament did indeed intend to rule over them with an iron hand.
Of all the Acts of Parliament that angered the American colonists and led to the Revolutionary War, the Declaratory Act is probably the least well-known, but may be one of the most important. It stated Parliament's clear intent and belief system regarding the colonies. The colonists were subjects of the Crown who could be ruled over at Parliament's pleasure, having no say in their own internal affairs.
Clearly, this was diametrically opposed to the colonists' belief that no power across the sea, where they had no representation, had any legal or moral authority to rule over them. The clash between these two points would end in a bloody revolution that would begin in only a few short years.
Interestingly, the Declaratory Act was still on the law books of Great Britain until 1964! The law asserted that Great Britain had full authority to make laws for all its colonies in the Western Hemisphere, including in the Caribbean, South America and Canada, not just in those colonies that would become the United States.
The last of these remaining colonies were given the right to have their own constitutions with the West Indies Act of 1962, making the Declaratory Act meaningless. Even though this law had been on the books since 1766, Parliament never again tried to tax its colonies after 1778, showing that the message that "taxation without representation" was wrong, had truly gotten through.
You can read the text of the Declaratory Act here.
Learn more about the history of the Stamp Act here.
You can read the text of the Stamp Act here.
And you can read the Act repealing the Stamp Act here.


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They might be words I wrote myself. And if they aren't they certainly convey a message that I have been promoting for quite a while now.
But whether I have written them or not doesn't really matter. The message still had enough power to stop even me in my tracks! And they will surely resonate with any business leader today.
So what were they? And who wrote them?
Now there is nothing new in the statement. After all we all know that change is ubiquitous. Even governments today are facing the need to change. What is striking is the claim that the 'ability to change' is the ultimate competitive advantage.
Yet it is not the statement itself that is so striking, but its implications. You see we are all dealing with change on a daily basis. And it's not just our experience; we read and hear so much about it that we have come to recognise change management as an essential competency. So of course you know that it is vital for survival. Therefore, even if you haven't spelled it out in so many words, you know that it has to be something that gives you a competitive advantage.
What is the difference? It is a small, subtle, but very significant difference. As the term implies, change management is the ability to deal with change. Change ability on the other hand is the ability to adapt to change. And that is where this book really comes into its own.
It makes the point that you traditionally build organisations to be stable. Organisational design and management theory and practice all aim to maintain control, consistency and order through best practice. As a result they are inherently change resistant. Thus change management, in the author's words, is about "unfreezing, moving and refreezing." This is clearly counter-productive in a world of constant change.
Yet we continue to work against ourselves. For example we increasingly recognise the importance of people and value for them for their ability to think, analyze and problem solve. Yet despite this, we continue to constrain them by imposing rigid job descriptions, rigid hours, and rigid rules and systems upon them. Thus you perpetuate the paradox: you want them to be more adaptable but create a culture that precludes this.
Clearly to create the competitive advantage to survive and thrive, you have to create a culture of change ability. And to do that, you have to have people who are totally aligned with the organisational objectives. So your challenge is to find a way to create that organisational alignment.
I cannot think of a better way to lay the foundation for change ability than by making the employees co-owners of the business. Can you? So what are you waiting for?
How HR can fill the gaps!
"Talent troubles – can HR fill the gaps?" That was the headline for the CIPD's "star article" in the February edition of "In a nutshell"; their pick of the best HR thinking for their members. The piece covers the findings of the 15th Annual Global CEO Survey conducted by PricewaterhouseCoopers, which – as the headline suggests – shows that there is no sign of the talent war abating.
Two fifth (40%) of IT companies have missed a market opportunity because they did not have a suitably skilled workforce.
One in three CEOs claim the skills shortage is helping their ability to innovate.
53% of CEOs see talent shortages as a top threat to business expansion.
So what is the CIPD take on this? "The opportunity this presents for the HR profession to finally get its due seems more promising than ever." (My emphasis.) It seems that the profession cannot stop seeing itself as hard done by. Is it possible that you earn "due"? And, if so, that perhaps this lack of "due" is an indictment of historic performance? If that is the case, then these findings damn the profession even more. Particularly when only a small minority of CEOs say their HR metrics provide enough information about their workforce for important strategic decisions.
Of course you cannot blame the CIPD for putting a positive spin on the findings. And they are right; they do present a wonderful opportunity. And you can certainly not blame them for not emphasising past shortcomings, even though this might have added a greater sense of need to take action – and even urgency. But it might have carried greater weight if they had simply said, "What a wonderful opportunity this presents to the HR profession." The implicit victimisation does the profession no favours.
Skills gaps and how to identify where to invest in employee development.
If you think about it, none of these are new requirements. Clearly, however, they are becoming more critical. And the HR profession is under the spotlight to see if it can deliver. In fact it is possibly Last Chance Saloon for the profession, because it will never "get its due" if it fails.
Fortunately you have a solution at your disposal right now. The Zealise proposition to value your people as human assets gives you the foundation to meet all those needs and close the gap completely. Let's take a closer look at the reasons for this claim.
It provides the catalyst to improve staff productivity by creating a framework for a partnership between employee and manager to optimise human asset value, which in turn will be maximised by performance. This is cemented by the unique employee ownership model it offers.
It simultaneously provides a framework for identifying employees needs because the need to optimise his/her asset value will impel the employee to voice their needs.
The inclusion of employees as human assets provides the means to consistently determine the ROI on human capital, as well as a benchmark for internal and external comparison.
The variation in human assets from one period to the next, combined with the above ROI capability, will provide an effective means to consistently assess the effect of employee turnover.
The assessment of staff productivity will simultaneously help to identify skills gaps and training needs.
It may not be a complete solution, but it is likely to be as effective as any tools you use currently. In addition, it will also provide you with a capability for conducting proper cost-benefit analysis on training, and will also create the capability to measure the ROI on training and development.
There you have it. If you are looking to close the gaps that your CEO is finding a challenge, you have the solution you need right here. So what are you waiting for?
It is hard enough to find a universal definition of employee engagement. Now new research identifies that there are 4 types of employee engagement.
Of course any research that throws new light onto the subject has to be welcome. The problem is that all this combines to make employee engagement so much more daunting. And goodness knows it can be daunting enough. You need to make the subject simpler, not more complex.
In an organisation that can make a difference.
I think we all know and understand that. So for me this research does not add anything new. It simply puts these basic elements into "management speak." It possibly provides a new credibility and gravitas to the subject, but that is about all.
Give them an ownership stake in the organisation.
Introduce an employee ownership scheme that cements their contribution to the organisation.
It really is not rocket science.
I know it dates me, but one of my abiding memories from school is haircut inspections, when prefects – those privileged elite empowered to enforce the rules - checked our hair. No, not for lice! They were checking to ensure that it wasn't too long!
So you can imagine how funny I found it when I learned a few years ago that prefects are still conducting hair inspections. Only now they are checking that hair is not too short! (Don't ask; I have no idea how they are expected to enforce that! In my day they could insist you had a hair-cut; but what do they do now – insist that you wear hair-extensions?) Well, traditions have been maintained! But if anything ever proved the inanity of rules for rules' sake this has to be it!
One has to laugh. Yet I remember this whenever I think of HR and the administration of work-force attendance. Ever since I can remember they have been focusing on efforts to reduce absenteeism and the lost productivity it causes. And here you cannot say the pendulum has swung, because they are still grappling with this problem. However, industry is also struggling to manage the opposite problem – presenteeism: people coming to work when they really are not well enough to do so, and thus presenting a health hazard to themselves and their fellow-workers.
So how do you manage two diametrically opposite actions? I know that if I were an HR Manager, I would throw my hands up in horror at being expected to do the seemingly impossible. But it is not only an HR problem; it affects all managers and leaders. So what are you doing about it?
Hopefully you are doing what most sensible people do when confronted with a challenge; looking behind the problem. Amusing though my analogy may be it highlights how easy it is to get caught up with the superficial. The fact is that it doesn't matter whether you are dealing with something as inane as the length of hair or something far more important, you are ultimately dealing with behaviour. Consequently you need to look at what you can do to remodel behaviour, not to reinforce rules.
And shaping behaviour is about leadership. That is why I found my friend Steve Roesler's blog "Leadership: It's about you" so interesting. I particularly enjoyed his Peter Drucker quote, "Look over your shoulder. If you don't see anyone you're not leading." If you put that in context, if people are not behaving in the way that you want them to, it is because you haven't convinced them of the need.
Take the absenteeism/presenteeism issue. For starters, do you really have the ability to (always) tell whether an employee's absence is justified or not? So why get into that territory? If you have people who don't care enough about their work to pitch up when they need to or who are so afraid of the consequences if they fail to pitch up when they know they really shouldn't, you don't have a rule-enforcement problem. You have an employee engagement problem.
And that being the case, what you need to do is create an environment where the individual has enough integrity to make that call for themselves and you and his colleagues have enough trust to respect their decision. That is about creating shared values and not rules. And that is the ultimate in leadership.
Of course, if you are looking for an ideal mechanism to prove your leadership and create those shared values, you don't need to look any further than an effective, equitable employee-ownership scheme. If the employee has a stake in the business and how it performs, they will be far more likely to make the decision that is best for both them and the business, because the two are aligned.
So this might just help you do the impossible! It is only a catalyst, but it will embed the ethics you want and engender the employee engagement that will ensure you get better results, whilst also taking away so much of the pain, frustration and wasted effort you currently put into trying to manage your people. It offers a win-win for everyone.


SOULSPARK – The Book that will empower you to make a positive transformation within yourself. Though spiritual awareness techniques, you will find YOUR Deep Truth, learn to love and accept the present, and transform YOUR dreams into reality. The Book will teach you The Big 8 Sacred Laws that will transform you from the inside out so that genuine love and happiness can settle in, the way it was always meant to be! Discover your inner Power!


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The Echelon. . HD Wallpaper and background images in the 30 seconds to mars club tagged: 30 seconds to mars 30stm jared leto echelon.
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Valeant pitches deadline delays to creditors in debt rescue plan
Mar 30, 2016 9:45am
Valeant has already said its tardy filings with the Securities & Exchange Commission could put it in jeopardy of defaulting on its debt. Now, it's asking its creditors for more time--and more leeway.
Wednesday, the Canadian drugmaker said it proposes to push its 10-K filing deadline to May 31 and its first-quarter 10-Q deadline to July 31. While it's still working to finish up the 10-K by April 29, the extensions would keep it out of trouble with creditors if it misses that date. Likewise on its June 14 target for the 10-Q.
Valeant's ($VRX) proposal would also get it off the hook for missing an earlier, March due date for the 10-K, it said.
But time isn't all the Quebec-based pharma needs. It's also asking its lenders for amendments and waivers to give it wiggle room. For instance, Valeant wants to ease the interest on its loans, which would "provide additional cushion" for its finances.
In return, Valeant would ratchet back acquisitions and dividend payments until all its filings are in place and the company hits its target leverage ratio. In the meantime, it would put "substantially all net asset sale proceeds" toward paying its loans.
Valeant first acknowledged that it was running into filing trouble earlier this month on a conference call with investors, who didn't take kindly to the news. A $58 million set of accounting missteps related to a now-nixed specialty pharmacy relationship--which a short seller in October accused Valeant of using to inflate its top line--are behind the hold-up.
Since then, outgoing CEO J. Michael Pearson has pledged to meet with creditors to work something out. But rumors have also circulated that some of those creditors would put Valeant's back to the wall, leveraging their position to raise the cost of the embattled pharma's debt.
For its latest proposal to succeed, the company will need a stamp of approval from lenders holding more than 50% of the principal on its loans. In the meantime, it's struggling on several other fronts; most recently, Pearson received a subpoena from Congress to answer for the company's hefty price increases on a pair of heart meds it purchased from Marathon last summer.
- read Valeant's release

redpajama_set_name: RedPajamaCommonCrawl


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Most Techies Work For Foreigners, Which Needs To Change, Says Alphons Joseph Kannanthanam, MoS
The greatest technological revolution are - schemes like Aadhaar, at least 70 per cent of population having access to toilets, and electricity supply to the last village and household in India
1526629674_wl7r87_Second-Story-Picture-470.jpg
by Manali
Our state of mind needs to be changed to see our country changing. People need to realise that India is their own country and a behavioural change has to come about to see our people and country at par with the developed world. Whenever I travel to countries like China, I find that DNA infused in people to keep their surrounding clean and feel a sense of belonging to their country," said Alphons at BW Businessworld's 4th Digital India Summit & Awards today in New Delhi today.
"We not only need to change our mindset but inculcate a sense of intent and belonging to our country in our DNA to bring out a change." Said Alphons Joseph Kannanthanam, Minister of State for Tourism, Government of India at BW Businessworld 4th Digital India Summit & Awards today in New Delhi today.
Addressing the audience at the event, Alphons said that the biggest technological revolution in the world has been undertaken the able guidance of Prime Minister Narendra Modi is providing the unique identification number Aadhaar to 1.24 billion people of India, which has not ever happened before.
"For me, the greatest technological revolution are - schemes like Aadhaar, at least 70 per cent of the population having access to toilets, and electricity supply to the last village and household in India," he added.
He also affirmed that the government needs to collaborate with private sectors to make sure that our intellectual property is not sold to foreign companies. Indigenous solutions and companies need to be prioritised especially in the field of technology. "98 per cent of IT/ITES services are provided by foreign companies, most of the techies are working for foreigners, which needs to change." he cited.
Alphons Joseph Kannanthanam tourism digital india summit 2018


SEOUL, Feb. 11 (Yonhap) -- President Moon Jae-in's approval rating rose above 50 percent for the first time in nearly three months last week, a poll showed Monday, amid optimism about rapprochement on the Korean Peninsula.
Moon's support came to 50.4 percent last week, up 1.6 percentage points from the previous week, according to a poll by Realmeter on 1,507 people across the country. The survey was conducted on Thursday and Friday.
The approval rating rose to the 50 percent level for the first time since the third week of November when it hit 52 percent.
The rebound appears to be affected by the government's efforts to revive the economy and news on a second summit between the United States and North Korea slated for later this month in Hanoi, the pollster said.
The support rating for the ruling Democratic Party rose 0.7 percentage point on-week to 38.9 percent last week. It ended a three straight weekly decline.
The reading for the main opposition Liberty Korea Party rose for the fourth straight week as competition for the party's leadership election heats up.


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All news Government and society Oil and gas
Pipeline delays stymie new growth in Canada's oil sands
March 13/ 09:07
Canada. Oil sands producers including MEG Energy Corp. and Imperial Oil Ltd. are reconsidering oil sands expansions as new export pipelines are delayed and the provincial government limits production.
MEG had planned to ramp up output at an expansion of its Christina Lake oil sands project in the second half of the year. Now, the "probability of that going ahead this year has decreased" after Enbridge Inc. announced a year delay on its Line 3 expansion, Derek Evans, MEG's chief executive officer, said March 8. In November, Imperial Oil Ltd said it would push ahead with the 75,000 barrel-a-day Aspen project. Last month, CEO Rich Kruger said the company is reevaluating its assumptions about Aspen after Alberta's oil curtailment "introduced new risk."
Nearly five years after oil prices collapsed and companies slashed spending, some oil sands producers had been looking to grow again. But pipeline shortages that sent Canadian heavy crude to $50 a barrel below West Texas Intermediate futures late last year and the government-mandated output cuts that followed have tempered the newfound optimism.
"We don't want to be building capacity into a system where we don't have the ability to move it," MEG's Evans said in a conference call last week.
Cenovus Energy Inc.'s Christina Lake phase G expansion is scheduled to be ready for production in the second quarter but the timing of the start-up will depend on "sustained improvements in market access and heavy oil pricing," Sonja Franklin, a company spokeswoman, said in an email.
Canadian Natural Resources Ltd. could defer the start up of the Kirby North project and has flexibility with its Primrose site if Canadian prices collapse again or there "is going to be a problem," Tim McKay, chief executive officer, said in a conference call March 7.
"It's just too early to say whether we'd start those projects up" or delay them, he said. "We have that optionality."
Canada's oil producers have struggled to export crude to the U.S. and other international markets after projects to expand pipelines were delayed and existing pipelines filled up. The Alberta government ordered producers to curtail supply in order to ease the glut and boost prices.
Pipeline Delays
Enbridge announced that its expanded Line 3 from Alberta to Wisconsin would start operation at the end of 2020, a year later than planned, because the permitting process won't be finished before November, told Bloomberg.
The Trans Mountain pipeline to Vancouver was delayed by at least a year after a court decision last summer forced a new regulatory review. Prior to the decision, the pipeline was purchased by Canada's federal government after Kinder Morgan Inc., the previous owner, threatened to cancel it amid environmental opposition.
A third pipeline project, TransCanada Corp.'s Keystone XL pipeline to the U.S. has yet to receive a final go-ahead from the company amid similar hurdles.


This tourist guide was created after gathering information from many different sources, like already existing printed material, but also from the personal knowledge of the writer, James G. Greenwood [26610 35636].
The photographs have also been gathered from several people, as well as from the writer's personal collection.
The writer, after agreement with the President of the community of Othoni, gives this guide only to the Division of Tourism Development of the Prefecture of Corfu, Committee for tourist promotion, for the creation of a website, as well as for any other legal use.


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John Grodzicki (February 26, 1917 – May 2, 1998) was an American Major League Baseball pitcher. A native of Nanticoke, Pennsylvania, he pitched for the St. Louis Cardinals in 1941, 1946 and 1947. The right-hander stood  and weighed .

A top pitching prospect before the outbreak of World War II, Grodzicki would pitch in 24 games (23 in a relief role) for the Cardinals, winning 2 and losing 2, with an earned run average of 4.43. He allowed 31 hits and 34 bases on balls in 40 MLB innings pitched, with 20 strikeouts.

Grodzicki's baseball career was interrupted by four years of military service. He served in the United States Army's 17th Airborne Division and became a paratrooper. In combat in Germany on March 29, 1945, Grodzicki sustained shrapnel wounds to both legs. He was awarded a Purple Heart, and required surgery and extensive rehabilitation to resume his baseball career after the war's end.

Grodzicki's professional playing career — spent entirely in the Cardinal organization — stretched from 1936 through 1952, including 11 years in minor league baseball. He later managed in the Redbird farm system, scouted for the Cardinals, then became a minor league instructor for the Detroit Tigers for over a dozen years. He then spent a season (1979) as the Tigers' MLB pitching coach. He died at age 81 in Daytona Beach, Florida.

References

External links

1917 births
1998 deaths
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redpajama_set_name: RedPajamaWikipedia


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Production starts at Giti U.S. plant
Bruce Davis
Tire Business photo by Bruce Davis
Giti Tire Group Chairman Enki Tan (center) points out features of his company's new tire plant in Richburg, S.C., to Greg Foran (right), CEO and president of Wal-Mart Stores Inc. and Dan Bartlett, executive VP, also of Wal-Mart.
RICHBURG, S.C. — Giti Tire Group has initiated production at its $560 million Richburg tire plant, making Singapore-headquartered Giti the 16th global tire maker with U.S.-based manufacturing capacity.
The plant's initial production is focused on Dextero-brand car tires for Wal-Mart Stores Inc., but the company is preparing to add GT Radial-brand production yet this year and launch a range of Giti-branded tires starting in 2018, Giti Tire (USA) Ltd. executives said during ceremonies held Oct. 4 to mark the start of production at the 1.7 million-sq.-ft. plant and distribution center.
South Carolina Gov. Henry McMaster and Wal-Mart Stores President and CEO Greg Foran were on hand along with other state, regional and local officials and plant supplier representatives to help mark the milestone.
An official plant opening ceremony is planned for next year, when OEM and dealer customers will have a chance to tour the facility.
Giti Tire Group marked the start of production at the firm's $560 million, 1.7 million-sq.-ft. Richburg tire plant and distribution center.
The factory, plans for which were announced in mid-2014, is scheduled to produce up to 200,000 Dextero-branded passenger tires for Wal-Mart this year, company officials said.
Production should ramp up to several million passenger and light truck tires in 2018, then to the plant's first-phase nameplate capacity of 5 million tires.
The factory's physical layout can accommodate a doubling of that capacity to 10 million tires "as demand warrants," according to Hank Eisenga, vice president, manufacturing and plant manager.
In his prepared remarks for the event, Giti Tire Group Chairman Enki Tan said his firm's investment in the plant "demonstrates our firm commitment to North American customers."
He lauded the "extensive infrastructure network" in Chester County, S.C., and a commitment to a highly skilled workforce for help to create a world-scale plant in rural South Carolina.
'America at Work'
Mr. Foran and a team of Wal-Mart executives headlined the event, which in part commemorated the retailing giant's "America at Work" initiative to solidify its relationship with U.S. suppliers and supply of U.S.-sourced goods.
In his remarks at the event, Mr. McMaster called the ingenuity, innovation, strength and determination exemplified by the Giti-Wal-Mart collaboration "off the scale."
Dr. Tan noted that Giti is the largest Wal-Mart supplier to date to have partnered with the Arkansas retailer in its America at Work initiative. He said his company's project in South Carolina thus far has involved more than 5,000 workers and will generate an estimated $1.2 billion in economic impact in the state.
State, regional and local governments committed more than $40 million in economic incentives toward the project in Chester County, about 40 miles south of Charlotte, N.C.
Wal-Mart has sold Dextero-brand tires at its Walmart auto care centers in the U.S. since 2012. Giti plans to shift that supply steadily to the Richburg plant from the Indonesian plant of its P.T. Gajah Tunggal affiliate, starting with the DHT2 and Touring DRT1 passenger lines.
"By investing in products that support American jobs, we were able to bring products to our shelves that our customers want and new jobs to the communities we serve," Mr. Foran said. A Boston Consulting survey estimated the Wal-Mart initiative will create 1 million new jobs in the U.S.
The plant is scheduled to make Dextero-, GT Radial- and Giti-brand tires, the latter of which is a new brand to be launched in 2018.
The South Carolina company, Giti Manufacturing (USA) Ltd., has about 200 employees working now and plans to have 400 by year-end, 1,000 by year-end 2018 and 1,700 at full capacity.
Giti also supplies Wal-Mart with tires for store operations in Brazil and China and is evaluating the feasibility of extending that relationship to other markets, Wal-Mart executives said.
Mr. Foran noted that Wal-Mart's association started several years ago when his company approached Giti about supplying up to 500,000 "opening price-point" tires to Walmart stores in the U.S.
Unlike other companies that often need weeks to respond, "Giti literally came back to us in less than four hours and said they could do it… . It was settled with a handshake."
Julianto Djajadi, executive vice president of business operations for Rancho Cucamonga, Calif.-based Giti Tire (USA), stressed that a fundamental reason for building in the U.S. is speed to market, noting that it can take 70 to 90 days now to fulfill orders from the company's Indonesian or China plants.
The manufacturing company said it works closely with York Technical College in Rock Hill, S.C., to recruit and train workers for the factory and has initiated a Math & Science Award with the Chester County School District to foster interest in the school system's STEM (science, technology, engineering and math) programs.
Mr. Eisenga — who joined Giti in 2015 after five years with Goodyear and a dozen with Continental Tire the Americas — said the Richburg plant is the most advanced technologically of Giti's eight factories worldwide, but stopped short of calling it fully automated.
"We're striving for a balance between technology and the human element," Mr. Eisenga said, noting that the key difference is striving for an optimum workflow.
Hamad Aboutorabi, director of Giti's Research & Development Center in Uniontown, Ohio, likened it to a symphony orchestra, saying the instruments — or in the case of a factory, the equipment — can't play themselves. They need skilled players and a talented director.
Giti Manufacturing , plans to have 1,700 employees when the plant is operating at full capacity.
The plant uses an array of state-of-the art processing equipment, including a half-dozen VMI Exxium single-stage tire building machines and 48 curing presses from Taiwan's Seyen Machinery Co. Ltd., with a dozen more being prepped for installation.
VMI Holland B.V. states the Exxium building machines are capable of handling rim diameters up to 24 inches with a building cycle of 40 seconds for a typical passenger tires, yielding a daily output of up to 1,600 tires.
The plant has its own rubber compounding capacity on site.
In his remarks at the event, Dr. Tan noted that Giti Tire is involved in an initiative with Conservation International to ensure that the company's carbon emissions are offset through the planting of nearly half a million trees and other measures, along with electricity and water-conservation efforts.
VW fitment
Giti Tire (USA) recently disclosed it had earned an original equipment fitment with Volkswagen of America for tires that will be manufactured at the new plant.
VW will fit its 2019 Passat being assembled in Chattanooga, Tenn., with the premium all-season Giti ComfortA1 in sizes 235/45R18 95H and 235/40R19 92H.
Singapore-headquartered Giti Tire Group is the world's 11th largest tire maker, based on 2016 sales of $3.03 billion, according to Tire Business' annual global tire rankings.
Giti officials declined to share specifics as to how the new Giti brand will be positioned vis-à-vis the GT Radial brand, but noted it will be the company's OE brand and stressed that up to now the company hasn't sold a corporate "namesake" brand in North America. The Giti brand is sold in other markets internationally, however, such as Brazil and China.
Giti Tire USA also is formulating a new brand image campaign and independent affiliated dealer sales/marketing program, according to Kenny Lee, senior director of marketing, North America, but the company's executive team declined to share specifics of either for now.
In the words of Armand Allaire, executive vice president of sales, "Stay tuned."


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Q: The system cannot find the file specified Till yesterday my webservice was running fine in my local system today when i run the Webservcie or any webproject from VS2005 i get the below error
Server Error in '/MyWebService' Application.
The system cannot find the file specified. (Exception from HRESULT: 0x80070002)
Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.
Exception Details: System.IO.FileNotFoundException: The system cannot find the file specified. (Exception from HRESULT: 0x80070002)
Please help me

redpajama_set_name: RedPajamaStackExchange


January 15, 2019 InderjeetLeave a Comment on Hum Chaar Trailer Reaction: It reminds you of your college time!
Rajshri Productions' upcoming film 'Hum Chaar' trailer is out and 'Hum Chaar' seems all about friendship. As it's tagline says 'Friends Bhi Family Hain'. Hum Chaar Trailer starts with a famous song 'Meri Dosti Mera Pyaar' from 1964 super hit film 'Dosti'. Trailer shows the post college time which often turns into misunderstandings and friends start losing each other. This trailer will surely remind you of your friend circle and college time.
Anshuman Malhotra, Prit Kamani, Tushar Pandey and Simran Sharma are the four musketeers of 'Hum Chaar'. We have seen Anshuman Malhotra as Young Haider in Shahid Kapoor starrer Haider. Tushar Panday has done movies like Phantom and Pink. Simran Sharma and Prit Kamani are debutants.
Here is the trailer of Hum Chaar, have a look!
'Hum Chaar' is written and directed by debutant director Abhishek Dixit while produced by Rajshri Productions.
Hum Chaar is releasing on 15th Feb in front of Ranveer Singh and Alia Bhatt 'Gully Boy' which is releasing one day before i.e. 14th Feb. This will be tough for 'Hum Chaar' to gain that much of audience before Gully Boy. But now era has changed and if content is there then audience won't let it go.
Stay tuned for further updates regarding Hum Chaar!


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Couple to bring Biggby Coffee to Reed City
Owners hope to open in May, June 2022
Bradley Massman, Editor
(From left) Sonya Bielecki and Kelly Prielipp recently announced they are in the process of opening a Biggby Coffee franchise in Reed City.
Photo courtesy of Sonya Bielecki
REED CITY — Coffee-lovers, rejoice. A Biggby Coffee franchise is on its way to Reed City, and the owners couldn't be more excited to share their excitement with the community.
Kelly Prielipp and Sonya Bielecki first met through a mutual employment in 2010. The pair of avid coffee drinkers fell in love and got married shortly thereafter. For years, the couple has enjoyed sipping on a hot cup of joe from Biggby Coffee.
For Bielecki, there's nothing better than a warm cup of Biggby's caramel mellow to start her day, and when it's in season, Prielipp can be found enjoying a spice pumpkin latte.
In 2011, Prielipp and Bielecki attended a Biggby Discovery Days event, which is where potential future owners can learn about the franchise and the requirements of owning one.
"(Opening a location) has always been in the back of our minds a little bit," Prielipp, a 1987 Reed City High graduate, said.
It was time to put the plan into action.
"I told Sonya, 'Reed City is such a cute town — how can we help?'" Prielipp recalled.
"I think we both want to be a part of the revitalization in Reed City, and there's no better way of doing that than through a Biggby Coffee," Bielecki said.
Prielipp and Bielecki began preparations to bring the franchise to Reed City. The couple recently gained a lot of popularity from the Reed City community after going public with their announcement on social media. Bielecki shared the news in a Facebook group called, "Let's talk about Reed City" and the post went viral, collecting over 500 reactions, nearly 300 positive comments, and 200-plus shares.
"I think there's no better job in the world than to make people smile with their favorite cup of joe," Bielecki said.
When it comes to a location for their new shop, Prielipp and Bielecki have an eye on a specific spot. However, there is a plan for a potential backup in the event their first choice doesn't work out.
"It's all dependent on Biggby," Prielipp said of the location selection. "You have to get the site approved through Biggby."
"There's a lot of red tape to go through," Bielecki added.
The couple is waiting for a final approval before announcing where in Reed City the new Biggby Coffee location will sit. But, Bielecki and Prielipp said they plan on keeping the community updated on their progress each step of the way — including live video updates on social media.
"We know the community wants it so we're acting as fast as we can," Bielecki said.
Prielipp said Biggby Coffee gives potential franchise owners one year to get a location approved by the company and then one year to get the store open and operating.
With a new establishment comes new jobs. Bielecki will be managing the store and Prielipp will be working behind the scenes, and they will be looking for employees to help staff the new coffee shop.
Bielecki and Prielipp said they would love to be open by May or June 2022, but noted a realistic opening date would be sometime in the fall.
"We had a feeling people wanted a Biggby, but didn't know to what extent," Bielecki said. "I think it's been amazing. The community is ready for this type of business to be local."
"We want to open a Biggby Coffee to help build the community," she added. "It's all about loving the people, and they will come."
Bradley Massman


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Cancer Institute Member Spotlight
Donghoon Yoon, Ph.D.
Assistant Professor Department of Internal Medicine UAMS College of Medicine Faculty, Graduate Program in Interdisciplinary Biomedical Sciences Research Interest Statement My research is investigating the pathophysiology of multiple myeloma (MM), a B-cell cancer characterized by proliferation of malignant plasma cells in the bone marrow, presence of monoclonal serum immunoglobulin and osteolytic lesions. MM studies demonstrate…
Charles O'Brien, Ph.D.
Professor Department of Internal Medicine Division of Endocrinology and Metabolism UAMS College of Medicine VA Research Scientist Research Interest Statement The focus of my research is to understand the cellular and molecular mechanisms that control bone remodeling. Alterations in bone remodeling underlie changes in the skeleton that lead to osteoporosis. As part of this effort,…
Merideth Addicott, Ph.D.
Assistant Professor Center for Addiction Research Department of Psychiatry UAMS College of Medicine Research Interest Statement My current tobacco research agenda extends in three directions. The primary direction is on the stress-smoking relationship. Tobacco addiction disproportionately affects individuals with mood disorders, and smokers may use tobacco to temporarily reduce stress, anxiety and depressed mood; albeit,…
Rupak Pathak, Ph.D.
Assistant Professor Division of Radiation Health Department of Pharmaceutical Sciences UAMS College of Pharmacy Research Interest Statement Dr. Pathak's research focuses on understanding the role of stromal cells in intestinal repair following injury, specifically after radiation injury. In addition, he is interested to dissect the underlying mechanisms of immune-epithelial crosstalk in intestinal restoration following localized…
Mayumi Nakagawa, M.D., Ph.D.
Professor of Pathology, College of Medicine Co-leader, Cancer Prevention and Population Sciences Program, Winthrop P. Rockefeller Cancer Institute Drs. Mae and Anderson Nettleship Endowed Chair in Oncologic Pathology Research Interest Statement The main focus of our research is to develop a human papillomavirus (HPV) therapeutic vaccine for preventing and treating HPV-associated cancers. It is called…
Donald J. Johann Jr., M.Sc., M.D., FACP
Associate Professor Department of Biomedical Informatics UAMS College of Medicine Scientific Director, UAMS Genomics Facility Research Interest Statement As a medical oncologist, I focus on the application of advanced molecular profiling and high-throughput technologies for the characterization of genetic-based alterations in cancer cells. Areas of emphasis include: cancer biology and bioinformatics; Next-Gen Sequencing (NGS), high-resolution…
Marjan Boerma, Ph.D.
Associate Professor of Pharmaceutical Sciences UAMS College of Pharmacy Research Interest Statement The overall objective of my research is to elucidate biological mechanisms by which ionizing radiation causes injury in normal (non-cancerous) tissues and to identify countermeasures to intervene in these injuries. Our laboratory has a particular focus on radiation injury in the cardiovascular system….
Benjamin Teeter, Ph.D.
Assistant Professor Center for Implementation Research Department of Pharmacy Practice UAMS College of Pharmacy Research Interest Statement My research program focuses on the improvement of patient care and public health through the application of implementation science. By studying how best to implement evidence-based interventions in community pharmacies, I hope to translate my research findings into…
Darin Jones, Ph.D.
Associate Professor of Pharmaceutical Sciences UAMS College of Pharmacy Research Interest Statement My research interests are broadly in the area of medicinal chemistry and chemical biology. Specifically we study essential proteins involved in DNA damage response and repair processes (DDR). Using fragment-based screening and computer-aided drug design techniques, we develop small molecule inhibitors and chemical…
Jeannette Y. Lee, Ph.D.
Professor Department of Biostatistics UAMS College of Medicine Research Interest Statement Dr. Lee is a biostatistician whose primary cancer research focus is in clinical trials for the prevention and treatment of malignancies in persons living with HIV/AIDS. She has been involved in the statistical design and analysis of phase I-III therapeutic trials and studies aimed…


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ASTANA. KAZINFORM - The Ministry for Investment and Development of the Republic of Kazakhstan has shared with Kazinform the full list of countries citizens of which will enjoy visa-free travel with Kazakhstan.
To date, Kazakhstan signed bilateral agreements on visa-free regime with 19 countries, including Azerbaijan (up to 30 days), Armenia (up to 90 days), Belarus (up to 90 days), Georgia (up to 90 days), Kyrgyzstan (up to 90 days),Moldova (up to 90 days), Russia (up to 90 days), Tajikistan (up to 30 days), Uzbekistan (up to 30 days), Ukraine (up to 90 days), Serbia (up to 30 days), Turkey (up to 30 days), Argentine (up to 30 days), Brazil (up to 30 days during a year), Cuba (has not yet become effective), Ecuador (up to 30 days during 180 days), Hong Kong SAR (up to 14 days), Mongolia (up to 90 days) and South Korea (up to 30 days).
Additionally, governments of Indonesia, Macedonia, Malaysia, Namibia, the Republic of Seychelles, Montenegro, Ecuador, the Philippines and Barbados, on a unilateral basis, granted visa-free travel for Kazakhstani citizens.
Nationals of Australia, Hungary, Italy, Monaco, Belgium, Spain, the Netherlands, Norway, Sweden, Malaysia, the United Arab Emirates, Singapore, Great Britain, the U.S., Germany, Finland, France, Switzerland and Japan can stay in Kazakhstan for up to 15 days without a visa in accordance with the decree of the Government of Kazakhstan as of June 26, 2015.
In order to enhance its investment and tourist attractiveness, Kazakhstan mulls introducing visa free regime for citizens of the United Arab Emirates, Malaysia, Singapore and Monaco as well as 35 OECD member states (the U.S., Australia, Austria, Belgium, Germany, Greece, Denmark, New Zealand, Japan, Israel, Ireland, Iceland, Spain, Italy, Canada, South Korea, Latvia, Luxembourg, Hungary, Mexico, the Netherlands, Norway, Poland, Portugal, Slovakia, Slovenia, Turkey, Great Britain, Finland, France, the Czech Republic, Chile, Switzerland, Sweden, Estonia) since January 1, 2017.
Bulgaria, Cyprus, Lithuania, Malta and Romania are likely to be included into the list in the nearest future.


Rio Ferdinand has been widely criticised for defending Newcastle United owner Mike Ashley's running of the club.
The retired defender was working for BT Sport as a pundit ahead of the Magpies' game at Chelsea on Saturday when presenter Jake Humphrey asked him for his opinion.
"It's got nothing to do with business dealings I've got with his company," said Ferdinand, whose Five brand is available to buy at Sports Direct, a sports-goods retailer founded by Ashley.
"I just think that when they went down, he spent £50-odd million to get them back up, of his own money. 'Thank you', that should be."
Humphrey questioned Ferdinand's comments, asking: "Wasn't it Newcastle's money that they generated in their time in the Premier League?" to which Ferdinand replied: "Well, he's the owner."
The 40-year-old went on to say Newcastle fans should be grateful Ashley appointed Rafael Benitez as manager, also describing the north-east side as "a yo-yo club" and adding: "He wants to sell the club, why should he go and spend millions of pounds?"
The video received thousands of replies from angry fans of Newcastle as well as supporters of other teams.
As an @Everton fan, with no axe to grind in this argument, I can say that @rioferdy5 is completely wrong. Newcastle fans deserve an owner who at least cares about the club and the likes of Brighton should not be outspending them, absolute joke.
Newcastle had the lowest net spend in the Premier League during pre-season, and currently find themselves in the relegation zone after a 2-1 defeat at Stamford Bridge.
The club also reportedly turned a profit last summer thanks to player sales.
Someone want to tell Rio about money coming in from player sales and the fans selling out every week?
Ferdinand appeared to double down on his comments on Sunday however, tweeting: "@NUFC fans good morning to you all!! Ya clubs turning a profit, no debt, oh and playing in the PL! Terrible!"
@NUFC fans good morning to you all!! Ya clubs turning a profit, no debt, oh & playing in the PL! Terrible!
Ashley has been in control of Newcastle United for more than a decade, and has so far failed in his attempts to sell the club.


text:
Unravelling the Complicated Networks of Integrin αIIbβ3 Signalling in Platelets
Author(s): Karen S. Harris, Denise E. Jackson	NHMRC Senior Research Fellow, Immunoreceptor Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg. Victoria 3084, Australia., Australia
Journal Name: Current Signal Transduction Therapy
DOI : 10.2174/157436208785699749
Maintenance of hemostasis and pathological thrombus formation are physiological processes inextricably reliant upon intracellular signalling in platelets. The initial tethering of platelets to pro-thrombotic agents exposed at the site of injury triggers molecular events that culminate in activation of the major platelet integrin, αIIbβ3 ("inside-out" signalling). The ensuing conformational change and integrin clustering modulates the affinity of this receptor for its ligands, facilitating stable platelet adhesion and aggregation and triggering integrin αIIbβ3-dependent signalling pathways that control thrombus stability ("outside-in" signalling). Many of the signalling molecules regulating these processes have been elucidated by use of specific inhibitors and knock-out mouse models. However, dissection of this dynamic network is confounded by factors such as the emphasis on different pathways under different conditions and functional redundancies. Furthermore, physiologically, multiple receptors may be simultaneously stimulated and act synergistically to regulate thrombus formation. This review will discuss current concepts in αIIbβ3-mediated signalling in platelets, with a particular focus on the "outside-in" pathways triggered upon αIIbβ3 ligand engagement. Understanding the molecular networks controlling hemostasis and pathological thrombus formation will be important for the development of highly specific therapeutics that can avert disease states without resulting in bleeding diathesis.
Keywords: Integrin αIIbβ3, outside-in signalling, inside-out signaling, platelet thrombus formation
Current Signal Transduction Therapy
Title: Unravelling the Complicated Networks of Integrin αIIbβ3 Signalling in Platelets
Author(s):Karen S. Harris and Denise E. Jackson
Affiliation:NHMRC Senior Research Fellow, Immunoreceptor Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg. Victoria 3084, Australia.
Keywords:Integrin αIIbβ3, outside-in signalling, inside-out signaling, platelet thrombus formation
Abstract: Maintenance of hemostasis and pathological thrombus formation are physiological processes inextricably reliant upon intracellular signalling in platelets. The initial tethering of platelets to pro-thrombotic agents exposed at the site of injury triggers molecular events that culminate in activation of the major platelet integrin, αIIbβ3 ("inside-out" signalling). The ensuing conformational change and integrin clustering modulates the affinity of this receptor for its ligands, facilitating stable platelet adhesion and aggregation and triggering integrin αIIbβ3-dependent signalling pathways that control thrombus stability ("outside-in" signalling). Many of the signalling molecules regulating these processes have been elucidated by use of specific inhibitors and knock-out mouse models. However, dissection of this dynamic network is confounded by factors such as the emphasis on different pathways under different conditions and functional redundancies. Furthermore, physiologically, multiple receptors may be simultaneously stimulated and act synergistically to regulate thrombus formation. This review will discuss current concepts in αIIbβ3-mediated signalling in platelets, with a particular focus on the "outside-in" pathways triggered upon αIIbβ3 ligand engagement. Understanding the molecular networks controlling hemostasis and pathological thrombus formation will be important for the development of highly specific therapeutics that can avert disease states without resulting in bleeding diathesis.
Karen S. Harris and Denise E. Jackson, " Unravelling the Complicated Networks of Integrin αIIbβ3 Signalling in Platelets", Current Signal Transduction Therapy (2008) 3: 158. https://doi.org/10.2174/157436208785699749
https://doi.org/10.2174/157436208785699749 Print ISSN
DOI: 10.2174/157436208785699749
Editorial (Thematic Issue: Medicinal Chemistry Studies of Neglected Diseases)
Mini-Reviews in Medicinal Chemistry
EDITORIAL: Vaccinology in the 21st century
Nanoparticles via Nanoprecipitation Process
Recent Patents on Drug Delivery & Formulation
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors
Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Targeting Cancer and Neuropathy with Histone Deacetylase Inhibitors:Two Birds with One Stone?
Asymmetric 1,3-Dipolar Cycloaddition of Chiral α, β-Unsaturated-γ-Sultams with Nitrile Oxides and Nitrones
Letters in Organic Chemistry
One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke
Vasopressin Antagonists as Anxiolytics and Antidepressants: Recent Developments
Recent Patents on CNS Drug Discovery (Discontinued)
Computational Models for Predicting Interactions with Cytochrome p450 Enzyme
Overview of Mechanisms of Cancer Stem Cell Drug Resistance
Astrocytic Signaling in Persistent Pain
Hematopoietic Progenitor and Stem Cells Circulate by Surfing on Intracellular Ca2+ Waves: A Novel Target for Cell-based Therapy and Anti-cancer Treatment?
The Senescent Mesenchymal Stem Cells in Systemic Lupus Erythematosus
Bladder Cancer and Stem Cells
Harmine Induces Gastric Cancer Cell Apoptosis through the ROSmediated PI3K/AKT Signaling Pathway
Renal Cell Carcinoma Cancer Stem Cells as Therapeutic Targets
The Effects of 5-Aza-2`-Deoxycytidine on DLC-1 Gene Expression, Methylation Level and Expression of Downstream Signaling Molecules Cdc42 in Multiple Myeloma
The Heterogeneity of Glioma Stem Cells
Optimization of the Enzymolysis Conditions for Scorpion Peptides and Evaluation of its Antitumor Activity


Wave Digital developed the Arro Home ecommerce store for Arro Home – a new homewares and lifestyle label. We proposed building the site in Magento and hosting the site on Amazon Web Services, which would allow the company and product offering to scale as they grew. Given the client's proven track record in developing consumer facing products of a similar nature, we felt that scalable cloud infrastructure supporting an extendable Magento system would deliver the best outcome. As a result, Arro were able to run promotional offers through the site and drive traffic to the site, safe in the knowledge that the scalable architecture would be able to cope with the resulting spikes in traffic.


I had the great pleasure of going to visit SpecialEffect at its headquarters in Oxford on Wednesday. The charity held a get together to thank supporters for their work during the Art Charity Auction back in December.
As I arrived at the building I was struck by how incredible it looked. I drove up a long road, flanked by trees all the way up to a Manor building where SpecialEffect is housed. I parked around the back and entered the easily accessible building where I was met by Hannah Whittaker, who works at SpeciaEffect.
As I entered the office I was greeted by Gavin Tan, who is a developer for the charity. I chatted with Gavin for a bit about games, that is the reason we are in this industry, and he then showed me some of the controllers they use to help disabled people to be able to play games.
The first controller I tried was the "EyeGaze". This is a device which tracks your eye movements and lets you do all the things you want on a computer using nothing but your eye movement. Following a quick calibration I got to play racing game, Dirt. To control the vehicle you moved your eyes to the top of the screen to go faster, to the bottom of the screen to brake and reverse and direct your eyes left or right to turn. I am normally terrible at racing games but using the EyeGaze I managed an average time which pleased me!
Following on from the EyeGaze I got to experience voice activated controls in Street Fighter. A control was set up which is used for movement and can be controlled by your chin with a sensitive microphone for the voice commands. The commands were simple like "Punch" for an uppercut, "Kick" for a spinning kick and "Move" to do a Hadouken.
Seeing and experiencing these controllers for myself really showed me how helpful these can be for people trying to get back in to gaming and back playing games on a level playing field. It truly is an amazing thing that the people at SpecialEffect do.
Over the next half an hour several games industry people turned up to the office for the event. There were people there from Sega, Warner Bros, and Take-two. Once everyone had arrived it was time for the main event.
Everyone was welcomed to the event by Kirsty Payne, a Vice President of SpecialEffect, who can be seen in the picture above. She gave a quick run down of the event in December. The art auction featured games art from across the industry and was held at the London City Hall and was visited by the Mayor of London, Boris Johnson. The auction managed to raise over £30,000!
The floor was then given over to Dr Mick Donegan, founder of SpecialEffect, who showed where the money will be going and who is being helped.
After the presentation SpecialEffect offered us drink and food. It was lovely just being able to talk with some of the games industry people who do so much for our industry and hearing their opinions on the games industry at the moment.
It was an incredible day and I will continue to do what I can for this amazing Charity! I will leave you with this amazing video of a young man called Alex who has been able to play games again and has used Special Effects help to be able to become a Train2Game student!
Posted in 2, Developer, game, games, Parent, Student, train, train 2 game, Train2Game	| Tagged 2, Art Auction, Boris Johnson, Dirt, Disabled Gamers, disabled gaming, Dr Mick Donegan, EyeGaze, game, Game Charity, games industry, Hannah Whittaker, Kirsty Payne, London city hall, London Mayor, PC gaming, SEGA, SpecialEffect, Street Fighter, Take-Two, train, Train2Game, Train2Game student, UK Games Industry, Video Games, Voice Commands, Warner Bros.
Take-Two boss, Strauss Zelnick, believes that developing for the next generation of consoles could be cheaper.
Despite the jump forward in technological prowess expected for Sony and Microsoft's next-gen consoles, Zelnick suggests that development costs may actually be lower than the present.
Sony and Microsoft are believed to start releasing news on the new consoles next year, hopefully followed by the release of one of them by the end of 2014.
There is still a long road ahead before the next generation so many things may change but as it stands at the moment the future looks bright.
There's no need to panic if no new console systems are shown off at E3 next week. In fact, an extended life cycle for the PlayStation 3 and Xbox 360 is good for game developers and publishers.
That's the view of Take-Two CEO Strauss Zelnick in an interview with MCV.
"There is still ample opportunity in the market with the current generation, provided that you deliver the highest quality entertainment experiences – which we always aim to do," he said.
Games coming from Take-Two in the near future include Borderlands 2, XCOM: Enemy Unknown, BioShock Infinite and Grand Theft Auto V, the latter of which doesn't have a release date as of yet.
"Hardware transitions historically have created both challenges and opportunities for third-party publishers. In order to succeed, it seems to me that any company needs: talent, tech, IP, and a strong balance sheet." Zelnick continued.
"Take-Two has all four. As always, we'll need to make triple-A titles that delight consumers. Frankly, our creative folks will be thrilled to have an opportunity to do just that." he added.
Keep reading The Train2Game Blog for the latest news on next gen consoles.
What are your thoughts on the possibility of next-gen consoles not turning up at E3? Do you think their needed yet? Or are developers doing just fine with the current crop?


wall art print.22 Buy it now Free P P All printers and monitors reproduce colors differently. H.88. The canvas is ready. Try finding the one that is right for you by choosing the price range, brand, or specifications that meet your needs. It was a sought after dress at the time and the only. International Fine Arts Consortium - ifac Arts Kate Moss Terry O'Neill Silver Gelatin Print Kate Moss, 1993 silver gelatin print 24 x 20 inches edition of 50 signed and numbered English supermodel Kate Moss, March 1993. Kate Moss Style Leopard Print Warehouse Size.99 0 bids.45 P P Silk Leopard Print Mini Dress from Warehouse. Flower Seller, Maroc, Silver Gelatin Print, 1989. International Fine Arts Consortium - ifac Arts Terry O'Neill Offered By International Fine Arts Consortium - ifac Arts Kate Moss Terry O'Neill C Print Kate Moss, 1995 C print 24 x 24 inches Signed and numbered edition of 50 Terry O'Neill (born ). Though a drug abuse scandal had dimmed her career for a short period she is still in the top 10 models of the fashion world and you will understand this very clearly when you go through her posters shown here.
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text:
Andrew Culverwell, född 19 december 1944 i Somerset i England, Storbritannien är en engelsk gospelmusiker, som spelade in skivor under 1970- och 80-talen. Han har bland annat skrivit julsången "Come on Ring Those Bells". Han flyttade sedan till Pompano Beach i Florida, och uppträder fortfarande i Fort Lauderdale i Florida.

Diskografi
Where is the Love? (1971) Polydor Records
Andrew (1973) Manna Records
Born Again (1975) Manna Records
This is the Song (1976)
Take Another Look (1978)-
Everyday (1980)
Alive Again (1982)
He Will Be There (1991)

Källor

Fotnoter

Gospelmusiker
Engelska låtskrivare
Engelska sångare
Brittiska musiker under 1900-talet
Personer från Somerset
Födda 1944
Levande personer
Män


Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Global Initiative for Chronic Obstructive Lung Disease. http://www.goldcopd.org/. 2010. Accessed 09 Sep 2011.
Ministry of Health Singapore. Clinical Practice Guidelines: use of antibiotics in adults. MOH (Singapore). http://www.moh.gov.sg/. Jan 2002.
Scottish Intercollegiate Guidelines Network. Community management of lower respiratory tract infections in adults: a national clinical guideline. SIGN. http://www.sign.ac.uk. 2002.


text:
Campionatul European de Scrimă pentru cadeți (U17) din 2015 s-a desfășurat în perioada 24-28 februarie la Maribor, Slovenia. A fost urmat de Campionatul European de Scrimă pentru juniori din 2015.

Rezultate

Masculin

Feminin

Clasament pe medalii
Legendă
 România

Legături externe
  Maribor: European Cadet Championships  la Confederația Europeană de Scrimă

2015
2015 în scrimă


Holiday home Insieme is located in the country in a hilly region near the town of San Valentino among olive trees and forests. The house is surrounded by the wonderful green of the garden and the oak trees, and offers the option to enjoy and relax in the garden or at the edge of the beautiful swimming pool. The house is tastefully furnished with a great deal of charm, with much light and warm colours. You step directly into the garden from every bedroom. It is a region with a rich historical, cultural and gastronomic tradition, and the area is known as the green heart of Europe. You have a view of the Majella mountain range and the Gran Sasso, beautiful nature parks which are definitely worth a visit.
The owner of the vacation home has three beautiful horses. It is possible to bring your own horse as there is a stable. From the holiday house you can make beautiful walks in the park Majella, also suitable for trips with a horse.


text:
1993 WTC Bombing Remembered Through a Glass Fragment
Window glass fragment recovered after the Feb. 26, 1993, World Trade Center bombing by FEMA responder Harold Edward Spedding, Gift of Daniel Sassa in remembrance of those lost in the 1993 and 2001 attacks on the World Trade Center. Photo by 9/11 Museum Collections staff.
Last year, the 9/11 Memorial Museum accepted a small fragment of green-tinted window glass into its collection. But this seemingly quotidian artifact had a more than 20-year journey to the 9/11 Memorial Museum and tells a critical story of the 1993 World Trade Center bombing.
The glass fragment originally belonged to Federal Emergency Management Agency responder and disaster specialist Harold Edward Spedding.
Spedding, who served a lengthy career in law enforcement with the New Jersey State Police before assuming a position with FEMA, responded to the World Trade Center shortly after the bombing on Feb. 26, 1993. Sifting through the debris, he recovered this piece of window glass and hand-etched its origin: "A remnant of #1 World Trade Center | February 26, 1993 | Was a piece of exterior window."
Following Spedding's passing in June 2016, Daniel Sassa, a volunteer firefighter and filmmaker, acquired the the glass fragment – along with a construction sign from the recovery and reconstruction effort and eight photos documenting the destruction of the 1993 bombing – from Spedding's son at an estate sale in southern New Jersey. When asked about the items, Sassa replied, "I knew they belonged in the museum's collection." The items were accepted in 2017.
Sassa is the nephew of Michael E. Roberts, a 31-year-old firefighter who was killed when responding to the World Trade Center with FDNY Engine Company 214 on Sept. 11. He has devoted himself to researching the construction and daily life of the original World Trade Center and has amassed a rich collection of artifacts and documents that trace this early history. Sassa's research has culminated in a book, "The World Trade Center: Construction of An American Icon," which was published in January 2018 and contains nearly 300 color photographs which depict the construction of the Twin Towers.
Sassa has previously made two other donations to the permanent collection, including a notebook binder titled "The Port of New York Authority: World Trade Center Study: Preliminary Engineering Report" from June 1960, an FBI "Wanted" poster for 1993 bombing conspirator, Ramzi Yousef, and a 7 World Trade Center baseball cap commemorating its opening day in 1987.
By Christine Murphy, External Affairs Project Coordinator and Executive Assistant, 9/11 Memorial & Museum
Remembering 1993 Victim William Macko
William Macko lived in Bayonne, N.J. He and his wife, Carol, had four children. William was a former U.S. Marine and enjoyed fishing and cooking. He worked for the Port Authority as an assistant chief mechanical supervisor for the World Trade Center.
Remembering 1993 Victim Wilfredo Mercado
Born in Lima, Peru, Wilfredo Mercado lived in East New York, Brooklyn, with his wife, Olga, and their two daughters. Wilfredo worked two jobs at the World Trade Center: weekdays as Windows on the World's purchasing agent and weekends as a security guard.