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Tag Archives: Documentary film
this day in the yesteryear: Edward White Becomes First American to Conduct a Spacewalk (1965)
Edward White Becomes First American to Conduct a Spacewalk (1965)
The first spacewalk by an American astronaut was conducted by Edward White during NASA's Gemini IV mission, which was itself the first multi-day space flight undertaken by the US. Assisted and photographed by fellow astronaut James McDivitt and tethered to the spacecraft for safety, White floated in space for 22 minutes. His spacewalk occurred just months after Russian cosmonaut Alexey Leonov executed the first ever extravehicular activity. How did White describe his reentry of the craft? More… Discuss
Posted in Educational, MEMORIES, PEOPLE AND PLACES HISTORY, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Special Interest, Uncategorized
Tagged Alexey Leonov, American astronaut, Astronaut, Charles Bolden, Documentary film, Edward Higgins White, Edward White, Extra-vehicular activity, Gemini 4, James McDivitt, NASA, spacewalk, United States
Beethoven's 5th Piano E-flat major, Op. 73 (Emperor) – Daniel Barenboim
mugge62
Beethoven's 5th Piano concert (Emperor) – Daniel Barenboim
Det kongelige kapel – Michael Schønvandt i Danmarks Radio Koncerthuset 2009 ved prisoverrækkelsen i København af Sonningprisen 2009 på 600,000 DKK ~ 125.000 US$ ~ The Sonning Prize Award is always held in Copenhagen, Denmark.
! The copyright © owner to all content in this video with The Royal Orchestra & Daniel Barenboim conducted by Michael Schønwandt, is entirely Danmarks Radio!
Also listen to Barenboims version of Noctune op. 27 no 2 by Chopin: http://www.youtube.com//watch?v=7EcER…
The Piano Concerto No. 5 in E-flat major, Op. 73, by Ludwig van Beethoven, popularly known as the Emperor Concerto, was his last piano concerto. It was written between 1809 and 1811 in Vienna, and was dedicated to Archduke Rudolf, Beethoven's patron and pupil. The first performance took place on 28 November 1811 at the Gewandhaus in Leipzig under conductor Johann Philipp Christian Schulz, the soloist being Friedrich Schneider.[1][2] On 12 February 1812, Carl Czerny, another student of Beethoven's, gave the Vienna debut of this work.The epithet of Emperor for this concerto was not Beethoven's own but was coined by Johann Baptist Cramer, the English publisher of the concerto.[3] Its duration is approximately forty minutes.
The concerto is scored for a solo piano, two flutes, two oboes, two clarinets in B-flat (clarinet I playing clarinet in A in movement 2; flute II, oboe II, clarinet II, both trumpets, and timpani are tacet during this movement), two bassoons, two horns, two trumpets, timpani in E-flat and B-flat, and strings.
The concerto is divided into three movements:
Allegro in E-flat major
Adagio un poco mosso in B major
Rondo: Allegro ma non troppo in E-flat major
As with Beethoven's other concertos from this time period, this work has a relatively long first movement. (At twenty-five minutes, the Violin Concerto has the longest; Piano Concerto Nos. 4 and 5 each have opening movements of about twenty minutes.)
In March 1927 Ignaz Friedman recorded the Emperor Concerto with the New Queen's Hall Orchestra under Henry Wood but this recording no longer exists.
Also in the 1920s, Wilhelm Backhaus recorded the 4th and 5th concertos very successfully. He would later record all five concertos with Hans Schmidt-Isserstedt and Vienna Philharmonic in stereo.
In the early 1930s Artur Schnabel recorded all five Beethoven concertos under Sir Malcolm Sargent and the London Symphony Orchestra.
Edwin Fischer recorded it with Karl Böhm in 1939 and Wilhelm Furtwängler in 1951.
Josef Hoffmann recorded it with the Chicago Symphony Orchestra, conducted by Hans Lange on May 12, 1940.
Arthur Rubinstein recorded it three times, with Josef Krips, Erich Leinsdorf, and Daniel Barenboim.
Walter Gieseking and Artur Rother made a stereophonic tape recording in 1944, apparently the earliest surviving such recording, for German radio.
Vladimir Horowitz recorded it in a 1952 live performance at Carnegie Hall with Fritz Reiner and the RCA Victor Symphony Orchestra.
Wilhelm Kempff recorded it with Paul van Kempen in 1953 and with Ferdinand Leitner in 1961.
Rudolf Serkin recorded it four times: in 1941 with Bruno Walter and the New York Philharmonic; in 1953 with Eugene Ormandy and the Philadelphia Orchestra; in 1962 with Leonard Bernstein conducting the New York Philharmonic, and in 1981 with the Boston Symphony Orchestra under Seiji Ozawa.
Bernstein recorded a live performance of the concerto in September 1989, shortly before his death, with Krystian Zimerman and the Vienna Philharmonic. The performance was filmed and released on DVD.
Leon Fleisher recorded all the Beethoven piano concertos with George Szell and the Cleveland Orchestra from 1959 until 1961.
Claudio Arrau recorded it four times: with Alceo Galliera in 1958, Bernard Haitink in 1964 and twice with Sir Colin Davis, first with the Royal Concertgebouw Orchestra and later with the Staatskapelle Dresden.
Glenn Gould recorded this concerto with Leopold Stokowski (the only recording the two ever made together) using somewhat non-traditional phrasings and tempi, as was typical of Gould's interpretations.
Maurizio Pollini recorded the five piano concertos twice for Deutsche Grammophon. First with Karl Böhm and the Vienna Philharmonic and later with Claudio Abbado and the Berlin Philharmonic.
Alfred Brendel recorded all Beethoven's piano concertos at least three times over his career.
Paul Lewis recorded all five of Beethoven's piano concertos with the BBC Symphony Orchestra with conductor Jiří Bělohlávek.
Murray Perahia recorded all five of Beethoven's piano concertos with the Royal Concertgebouw Orchestra with conductor Bernard Haitink, 1988.
this day in the yesteryear: Beethoven's Ninth Symphony Premieres in Vienna (1824)
Posted in ARTISTS AND ARTS - Music, Arts, Educational, IN THE SPOTLIGHT, MEMORIES, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, Special Interest, Uncategorized, YouTube/SoundCloud: Music, YouTube/SoundCloud: Music, Special Interest
Tagged Agra, Amateur, anton diabelli, Artistic director, Associated Press, Beethoven, Belgium, Bonn, Burial, Contemporary ballet, Copenhagen, Danish language, Danish Security and Intelligence Service, Denmark, Documentary film, Double bass, emperor concerto, Intelligence agency, Islam, Ludwig van Beethoven, Piano concerto, Police, Royal Orchestra & Daniel Barenboim, Security agency, vienna philharmonic
Documentary | The Boy With Divine Powers – History Channel – National Geographic
Full Documentary
national geographic 2014
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documentary films 2014
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national geographic,national geographic 2014,national geographic documentary,documentary,documentary 2014,documentaries,documentaries 2014,bbc documentary,discovery channel,history channel,history channel documentary,national geographic channel,documentary films,documentary films 2014,national geographic animals,documentary history channel,documentaries national geographic,documentary national geographic,discovery channel documentary,taboo,national anthem,geographic national,documentaries discovery channel,nat geo,documentary bbc,anorexia documentary,serial killer documentary,slender man documentary,lil wayne documentary,discovery channel documentary,north korea documentary,ufo documentary,bbc documentary history,pbs documentary,holocaust documentary,prison documentary,the game documentary,illuminati documentary,chernobyl documentary,ww2 documentary,lion documentary,conspiracy documentary,animal planetnational geographic documentaries,honey badger,in the womb,lockdown,gangland,discovery,border wars,lions,sharks,movies,Full Movie,national,lion,nature,animal videos
Source : http://youtu.be/CYjex1pxz_4
Posted in Educational, Facebook, FILM, Gougle+, IN THE SPOTLIGHT, News, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Social Media, SoundCloud, Special Interest, SPIRITUALITY, Twitter, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged 9/11 Truth movement, A Prairie Home Companion (film), All Good Things (film), bbc documentary, Documentary, Documentary film, documentary films, Genetically modified organism, Green, Grim Sleeper, Have Mercy on Us All (film), National Geographic, Nick Broomfield, serial killer
One Summer's Day from – Spirited Away. Spirited Away (千と千尋の神隠し) is a 2001 film by Studio Ghibli, written and directed by Hayao Miyazaki: It become the highest-grossing film in Japanese history.
久石讓 Joe hisaishi Live – One Summer's Day (from Spirited Away)
Musical World of Joe
Uploaded on Nov 16, 2007/5,450,022 views
One Summer's Day from – Spirited Away.
Spirited Away (千と千尋の神隠し) is a 2001 film by the Japanese anime studio Studio Ghibli, written and directed by famed animator Hayao Miyazaki.The film received many awards, including the second Oscar ever awarded for Best Animated Feature, the first anime film to win an Academy Award, and the only winner of that award to be traditionally animated or win among five nominees (in every other year there were three nominees).
The film also won the Golden Bear at the 2002 Berlin International Film Festival.
Spirited Away overtook Titanic to become the highest-grossing film in Japanese history.
Posted in ARTISTS AND ARTS - Music, Educational, FILM, IN THE SPOTLIGHT, MEMORIES, MY TAKE ON THINGS, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Special Interest, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged Academy Award, Documentary film, Grave of the Fireflies, Hayao Miyazaki, Japan, Joe Hisaishi, Kiki's Delivery Service, My Neighbor Totoro, Spirited Away, Studio Ghibli
Duo Kontarsky @ BIZET Jeux d'enfants Op.22 – 1982 *vinyl* , great compositions/performances
Duo Kontarsky @ BIZET Jeux d'enfants Op.22 – 1982 *vinyl*
Emilio Pessina
Georges BIZET: Jeux d'enfants Op.22, 12 pieces for piano 4 hands
0:05 / 1. L'Escarpolette (Reverie. Andantino) [2'52"]
2:57 / 2. La Toupie (Impromptu. Allegro vivo) [0'57"]
3:53 / 3. La Poupée (Berceuse. Andantino semplice) [2'49"]
6:42 / 4. Les Chevaux de Bois (Scherzo. Allegro vivo) [1'18"]
8:01 / 5. Le Volant (Fantaisie. Andantino molto) [1'14"]
9:15 / 6. Trompette et Tambour (Marche. Allegretto) [2'07"]
11:22 / 7. Les Bulles de Savon (Rondino. Allegretto) [1'22"]
12:44 / 8. Les Quatre Coins (Esquisse. Allegro vivo) [2'07"]
14:52 / 9. Colin-Maillard (Nocturno. Andante non troppo) [1'58"]
16:50 / 10. Saute-Mouton (Caprice. Allegro molto) [1'21"]
18:10 / 11. Petit Mari, petite Femme! (Duo. Andantino) [3'00"]
21:10 / 12. Le Bal (Galop. Presto) [1'39"]
Alfons & Aloys Kontarsky, piano (rec. 1982 – vinyl (p)1983 DGG)
Alfons & Aloys KONTARSKY – piano duet *vinyl*
http://www.youtube.com/playlist?list=…
(c) COPYRIGHT Disclaimer, Under Section 107 of the Copyright Act 1976. Allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
Posted in ARTISTS AND ARTS - Music, Educational, IN THE SPOTLIGHT, MEMORIES, MY TAKE ON THINGS, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Special Interest, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged #euzicasas, Archivist, Best practice, Copyright, Copyright Act of 1976, Copyright infringement, Copyright registration, Copyright Vs Trademark, Documentary film, Duo Kontarsky @ BIZET Jeux d'enfants Op.22 - 1982 *vinyl*, Education, Fair use, Great Compositions/Performances
People and Places: Tsukiji Fish Market
The Tokyo Metropolitan Central Wholesale Market, or Tsukiji fish market, is the biggest wholesale fish and seafood market in the world. Located in Tokyo, Japan, the market offers more than 400 types of seafood and is a major attraction for foreign visitors. It typically opens at 3 AM, with auctions beginning around 5 AM. Bidding can only be done by licensed participants, but visitors can watch. What were the "Rice Riots," and how did they lead to the creation of the Tsukiji fish market? More… Discuss
Posted in Educational, IN THE SPOTLIGHT, MY TAKE ON THINGS, News, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Special Interest, Uncategorized
Tagged American Airlines, BC Astana, Consumption (economics), Dallas, Documentary film, Economy of Japan, Embedded system, Emergency landing, Japan, Rice Riots, Tokyo, Tokyo Metropolitan Central Wholesale Market, Tsukiji fish market
Georges Brassens – Il n'y a pas d'amour heureux (live) 1965: "…Le temps d'apprendre à vivre il est déjà trop tard Que pleurent dans la nuit nos cœurs à l'unisson…"
Georges Brassens – Il n'y a pas d'amour heureux (live) 1965
amicafragile1
Georges Brassens – Il n'y a pas d'Amour Heureux, 1965
(music de Georges Brassens – poeme de Louis Aragon)
Rien n'est jamais acquis à l'homme. Ni sa force
Ni sa faiblesse ni son cœur. Et quand il croit
Ouvrir ses bras son ombre est celle d'une croix
Et quand il croit serrer son bonheur il le broie
Sa vie est un étrange et douloureux divorce
Il n'y a pas d'amour heureux
Sa vie elle ressemble à ces soldats sans armes
Qu'on avait habillés pour un autre destin
A quoi peut leur servir de ce lever matin
Eux qu'on retrouve au soir désarmés incertains
Dites ces mots ma vie et retenez vos larmes
Mon bel amour mon cher amour ma déchirure
Je te porte dans moi comme un oiseau blessé
Et ceux-là sans savoir nous regardent passer
Répétant après moi les mots que j'ai tressés
Et qui pour tes grands yeux tout aussitôt moururent
Le temps d'apprendre à vivre il est déjà trop tard
Que pleurent dans la nuit nos cœurs à l'unisson
Ce qu'il faut de malheur pour la moindre chanson
Ce qu'il faut de regrets pour payer un frisson
Ce qu'il faut de sanglots pour un air de guitare
Il n'y a pas d'amour qui ne soit à douleur
Il n'y a pas d'amour dont on ne soit meurtri
Il n'y a pas d'amour dont on ne soit flétri
Et pas plus que de toi l'amour de la patrie
Il n'y a pas d'amour qui ne vive de pleurs
Posted in ARTISTS AND ARTS - Music, Educational, IN THE SPOTLIGHT, MEMORIES, MY TAKE ON THINGS, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, QUOTATION, Special Interest, SPIRITUALITY, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged Clamato, Colette, Critical point (thermodynamics), Dames, Documentary film, Film director, Georges Brassens, Linkback, louis aragon, Mustard (condiment)
Koch Brothers Exposed: The Chilling New Documentary Republicans Don't Want You to See
[youtube.com/watch?v=7YhEgLhV6ro]
http://www.democracynow.org – There is a chilling new documentary about the billionaire brothers, David and Charles Koch, that some Republicans do not want you to see. On Monday, Republican Rep. Candice Miller of Michigan tried to block an event at the Capitol unveiling the film, "Koch Brothers Exposed: 2014 Edition." Miller claimed the documentary could violate House rules and "cross the line into partisan politics." She unsuccessfully argued that showing the documentary was an inappropriate use of taxpayer-funded facilities. On Tuesday evening, the film event proceeded as planned. The updated documentary shows how the Koch brothers have used their vast fortunes to oppose government programs such as Medicaid, Medicare and Social Security as well as obstruct efforts to raise the minimum wage, tackle climate change and expand voting rights. We are joined by the film's director, Robert Greenwald, founder and president of Brave New Films.
Click here to see all Democracy Now! coverage of the influence of the Koch Brothers:
http://www.democracynow.org/topics/ko…
Democracy Now!, is an independent global news hour that airs weekdays on 1,200+ TV and radio stations Monday through Friday. Watch our livestream 8-9am ET at http://www.democracynow.org.
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New documentary film exposing the Koch brothers debuts tonight on the internet and it's free
Reid Defends Using Taxpayer Funds To Screen Anti-Koch Brothers Film In Capitol, Blames Criticism On . . . The Koch Brothers…
11 things the Koch brothers don't want you to know
Watch 'Koch Brothers Exposed' Tonight – For Free!
Koch Bros Set to Spend LESS THAN HALF the Amount of Democrat Tom Steger on 2014 Elections
11 Things The Koch Brothers Don't Want You To Know, From Robert Greenwald's Newly Updated Documentary
Reid defends screening of Koch film
Posted in Educational, IN THE SPOTLIGHT, MEMORIES, MY TAKE ON THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged Brave New Films, Candice Miller, Charles G. Koch, David and Charles Koch, Documentary film, Koch, koch brothers, Koch Brothers Exposed, Michigan, Robert Greenwald, YouTube
The Vikings : Documentary on the Life, Culture, and Legacy of Vikings (Full Documentary)
This documentary and the rest of the documentaries presented relate to important times and figures in history, historic places and sites, archaeology, science, conspiracy theories, and education.
The Topics of these video documentaries are varied and cover ancient history, Rome, Greece, Egypt, science, technology, nature, planet earth, the solar system, the universe, World wars, Battles, education, Biographies, television, archaeology, Illuminati, Area 51, serial killers, paranormal, supernatural, cults, government cover-ups, corruption, martial arts, space, aliens, ufos, conspiracy theories, Annunaki, Nibiru, Nephilim, satanic rituals, religion, strange phenomenon, origins of Mankind
Posted in Educational, FILM, IN THE SPOTLIGHT, MEMORIES, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized
Tagged Anunnaki, Area 51, conspiracy theories, documentaries, Documentary, Documentary film, Egypt, Greece, Illuminati, Legacy of Vikings, Nephilim, Rome, Vikings
SoudCloud My Poetic thoughts Recitation Here 0
Plinky 0
Miss Fisher's Murder Mysteries 0


Borealis and Borouge, leading providers of innovative, value-creating plastics solutions, announce the launch of several new polypropylene (PP) compounds in the Daplen™ family of PP thermoplastic olefin (TPO) compounds, and the Fibremod™ range of PP fibre reinforced compounds. These innovative new additions to Borealis' proven range of lightweighting solutions for interior, exterior, and under-the-bonnet (UTB) automotive parts offer even more lightweighting potential.
Importantly, these solutions also allow for design freedom and flexibility for vehicles with hybrid or electric powertrains. While the automotive industry strives to improve the environmental performance of internal combustion engine (ICE) technology, alternative powertrains are gaining in importance. Borealis and Borouge are leveraging their polyolefins expertise to develop value-creating and innovative solutions that offer more design freedom and enable vehicular weight savings, whilst requiring no compromises when it comes to mechanical properties.
Lightweight design, including the use of robust yet lightweight materials, has become an industry imperative. Lightweighting helps reduce vehicular CO2 emissions and thus plays a crucial role in enabling manufacturers to adhere to regulatory standards. Yet some experts predict that alternative powertrains, like those for electric vehicles, will gain significant market share by 2030. At the same time, an exciting new gamut of design possibilities can be realised with electric and autonomous vehicles.
For example, components in battery electric and fuel cell electric vehicles can be fundamentally redesigned for low-density PP compounds due to lower operating temperatures versus ICE powertrains. Components such as tailgates and front end modules can be executed in monomaterial PP solutions that are not only lighter weight, but are more easily recycled. And where metal and higher-cost engineering plastics were once the material of choice for structural elements, PP-based compounds can now be considered for such applications.
Several new grades from the Daplen PP TPO and Fibremod PP fibre reinforced compound families that unite robust performance properties with easy processing will be launched at the International Plastics in Automotive Engineering conference, held by VDI in Mannheim, at the end of March this year.
The proprietary Fibremod long glass fibre reinforced polypropylene (PP-LGF) technology is known for its excellent fibre impregnation and flexibility in allowing for use of various polypropylene matrices, and the production of grades in customised colours. With the commercial launch of LGF Fibremod™ GB416LF with 40% filler content, Borealis is further differentiating its product offer by offering a new, lighter weight solution for a full polyolefin tailgate module as a lower-density replacement solution for conventional metal or engineering polymers. As a high-flow material, Fibremod GB416LF fulfils both emission requirements and mechanical performance criteria. With excellent surface aesthetics, the grade can be used for visible parts. Its sustainability is enhanced not only by its lighter weight, but by eliminating the need for one or more paint layers, or additional aesthetic parts.
Fibremod™ GD577SF, a new short glass fibre (SGF) grade with 50% filler, is another important extension of the Fibremod portfolio. In addition to its outstanding mechanical performance – even at higher temperatures – the grade also offers pleasing surface qualities for visible structural parts. As a potential replacement solution for demanding metal and polyamide (PA) applications, GD577SF is suited for a diverse range of exterior, interior and UTB applications, including full plastic front end modules, clutch and gas pedals, external mirror structures, and more.
As a new material generation designed to serve as a "drop-in" solution, the highly pure Daplen™ EE001AI boasts excellent mechanical properties and minimal filler content. With the similar shrinkage characteristics typical of grades with higher filler content (such as PP-T15), the new Daplen EE001AI can be used in existing tool geometries. It maintains the proven Daplen characteristics of processability and robustness in large-scale series production. While it is a lightweight grade, it certainly pulls its weight when it comes to surface aesthetics, and can be used to achieve class-A surfaces free of tiger stripes and any other visible flaws typically affecting injection-moulded parts. It is highly suitable for a wide range of injection configurations and tool layouts.
Visit us at VDI Mannheim in Mannheim, Germany, from 29-30 March 2017 at Stand 54 to learn more about how Borealis and Borouge are further developing the innovative Fibremod, Fibremod Carbon, and Daplen portfolios.
For over 50 years, Borealis has been a leading supplier of innovative polyolefin plastic materials for engineering applications in the automotive industry. Using its unique and proprietary Borstar® technology and its Fibremod™ post-reactor technology for fibre reinforced polypropylene (PP) compounds, Borealis delivers ideal replacement solutions for conventional materials such as metal, rubber and engineering polymers. Borealis continues to discover new material solutions which help facilitate lightweight construction and thus play an important role in enhancing energy efficiency. In automotive vehicles, Borealis' leading-edge polyolefin plastic materials are used in a wide range of exterior, interior, and under-the-bonnet applications, including bumpers, body panels, trims, dashboards, door claddings, climate control and cooling systems, air intake manifolds and battery cases.
Daplen, Fibremod and Water for the World are trademarks of the Borealis Group.


This is a cute song to help you teach the concept of "How"
It includes the meaning and examples of its use so your kiddos can practice asking and answering How questions. Video includes words at times for better understanding and visual cues.
You can even divide the kids into 2 groups, one asking the question and one answering.
It includes a full video file. You can choose to play it in the speech-language therapy room if you want, or just watch it during sessions!
Prime your students by learning it, and reward them with watching it.
Use it as a music cue when you need to work on "How" questions in language therapy.
Fun for all ages and skill levels.


text:
Forgotten Radicals in Biology
Rochette Luc 1, 2, 3 Catherine Vergely 1, 3, 2
Rochette Luc 1, 2, 3 AuthorId : 12489124
Catherine Vergely 1, 3, 2 AuthorId : 1465335
Abstract : redox reactions play key roles in intra-and inter-cellular signaling, and in adaptative processes of tissues towards stress. Among the major free radicals with essential functions in cells are reactive oxygen species (rOs) including superoxide anion (O 2 •-), hydroxyl radical (• OH) and reactive nitrogen species (rNs) such as nitric oxide (• NO). In this article, we review the forgotten and new radicals with potential relevance to cardiovascular pathophysiology. Approximately 0.3% of O 2 •present in cytosol exists in its protonated form: hydroperoxyl radical (HO 2 •). Water (H 2 O) can be split into two free radicals: • OH and hydrogen radical (H •). several free radicals, including thiyl radicals (rs •) and nitrogen dioxide (NO 2 •) are known to isomerize double bonds. In the omega-6 series of poly-unsaturated fatty acids (PUFAs), cis-trans isomerization of γ-linolenate and arachidonate catalyzed by rs • has been investigated. Evidence is emerging that hydrogen disulphide (H 2 s) is a signaling molecule in vivo which can be a source of free radicals. the cu-Zn superoxide dismutase (sOD) enzyme can oxidize the ionized form of H 2 s to hydro-sulphide radical: Hs •. recent studies suggest that H 2 s plays an important function in cardiovascular functions. carbonate radical, which can be formed when • OH reacts with carbonate or bicarbonate ions, is also involved in the activity of cu-Zn-sOD. recently, it has been reported that carbonate anion were potentially relevant oxidants of nucleic acids in physiological environments. In conclusion, there is solid evidence supporting the formation of many free radicals by cells leading which may play an important role in their homeostasis.
Keywords : free radicals reactive oxygen nitrogen species cardiovascular physiopathology hydrogen disulphide
Rochette Luc, Catherine Vergely. Forgotten Radicals in Biology. International Journal of Biomedical Sciences, World Academy of Science, Engineering and Technology, 2008. ⟨hal-03437209⟩

redpajama_set_name: RedPajamaCommonCrawl


Felony Lawyers in Robertsdale, Alabama are legal professionals who have the skills to represent their clients who have been charged with a felony. A felony charge is serious business because it carries a possible sentence of at least 1 year minimum prison time.
You should seek the advice of a knowledgeable felony lawyer in Robertsdale, Alabama.
Felony charges affect your life in many ways including your employment options as well as your right to vote. It's best to hire a reputable felony attorney who will work to find the best path for you, be it plea bargaining or fighting the case, so that you can proactively resolve all legal issues. It is strongly recommended that you don't go this alone; you should seek counsel from a skilled felony lawyer in Robertsdale, Alabama.
Each court has its own rules, and knowing how to navigate them will be key to a successful defense of your charges. You have the best chance of a positive outcome by consulting with a lawyer as soon as possible. Locate an efficient felony attorney in Robertsdale, Alabama as soon as possible to make sure you mount the best defense for your case.


text:
Q: Tab bar doesn't show up iOS Added Tab bar view controller to my project and it doesn't show up in the app, it shows up in interface builder, but not in the app. And when I go to the Cards view controller it shows a black line above toolbar (second pic). What could be the problem here?

    class CardsTableViewController: UITableViewController {

        var cards: Results<Card>?
        let realm = try! Realm()
        var cardFromResult: Card?
        var alreadyHighLighted: Bool = false
        var cellIndexPath: IndexPath? {
            didSet {
                if !alreadyHighLighted {
                    DispatchQueue.main.async {
                        self.tableView.scrollToRow(at: self.cellIndexPath!, at: .middle, animated: true)
                        self.tableView.selectRow(at: self.cellIndexPath!, animated: true, scrollPosition: .middle)
                    }
                    DispatchQueue.main.asyncAfter(deadline: .now() + 0.7) {
                        self.tableView.deselectRow(at: self.cellIndexPath!, animated: true)
                        self.alreadyHighLighted = true
                    }
                }
            }
        }
        var selectedDeck: Deck? {
            didSet {
                loadCards()
            }
        }

        @IBOutlet var reviewButton: UIBarButtonItem!

        override func viewDidLoad() {
            super.viewDidLoad()
            navigationItem.title = selectedDeck?.name
            tableView.tableFooterView = UIView()
        }

        override func viewWillAppear(_ animated: Bool) {
            super.viewWillAppear(animated)
            tableView.reloadData()
            if cards?.count == 0 {
                navigationController?.setToolbarHidden(true, animated: false)
            } else {
                navigationController?.setToolbarHidden(false, animated: false)
            }
        }

        override func viewWillDisappear(_ animated: Bool) {
            super.viewDidDisappear(animated)
            navigationController?.setToolbarHidden(true, animated: false)
        }
}

redpajama_set_name: RedPajamaStackExchange


DVT50: The effect of a surfactant as an emulsifier is based on the fact that it reduces the interfacial tension between phases which do not easily mix. As surfactants need a certain time to do this, the effect of an emulsifier depends on the mixing dynamics. With DVT50, you can measure the speed with which emulsifiers produce their effect and reduce the interfacial tension.
Whether pumping, stirring or flooding: oil-water interfaces are always in motion. The drop volume technique of the DVT50 from KRÜSS records the interfacial tension under dynamic conditions – in an interface age range from fractions of a second up to several minutes.


text:
The 2005–06 Northwestern State Demons basketball team represented Northwestern State University during the 2005–06 NCAA Division I men's basketball season. The Demons, led by 7th year head coach Mike McConathy, played their home games at Prather Coliseum and were members of the Southland Conference. They finished the season 26–8, 15–1 in Southland play to win the regular season title. They were champions of the Southland Conference tournament, winning the championship game over Stephen F. Austin, to earn an automatic bid to the 2006 NCAA tournament. As No. 14 seed in the Atlanta region, Northwestern State knocked off No. 3 seed Iowa by draining a corner three with time running out. The Demons were then beaten by No. 6 seed West Virginia in the second round.

Roster

Schedule and results

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!colspan=9 style=| Non-conference Regular season

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!colspan=9 style=| Southland Regular season

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!colspan=9 style=| 2006 Southland Conference tournament

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!colspan=9 style=|2006 NCAA tournament

References

Northwestern State
Northwestern State
Northwestern State Demons basketball seasons
2005 in sports in Louisiana
2006 in sports in Louisiana

redpajama_set_name: RedPajamaWikipedia


TWO URBAN LICKS' INCREDIBLE WOOD-FIRED CUISINE, LIVE ROTATING ROTISSERIES, UNIQUE 26 FOOT WINE ON TAP BARREL WALL (THE FIRST IN THE COUNTRY!), FUNKY LIVE BLUES, BREATHTAKING DOWNTOWN SKYLINE VIEWS AND THE "WOW" DESIGN CENTERED AROUND THE FLOOR TO CEILING TODD MURPHY PAINTING LIT BY A GAS LAMP WALL MAKES TWO TRULY ONE OF A KIND. THE INNOVATIVE, DOMESTIC AND INTERNATIONAL, WINE PROGRAM CONSISTS SOLELY OF STAINLESS STEEL BARRELS OF WINE DISPLAYED IN A 26 FOOT, GLASS AND STEEL, TEMPERATURE CONTROLLED TOWER SITUATED PROMINENTLY IN THE RESTAURANT. WINES ARE DRAWN BY GRAVITY AND SERVED AS A HALF GLASS, GLASS, MINI THIEF (10 OUNCES), HALF THIEF (20 OUNCES), AND FULL THIEF (42 OUNCES). THE TOWER, WHICH CAN HOLD 6 BARRELS ACROSS, FEATURES A GRAVITY FLOWED SYSTEM FOR POURING AND A SCISSOR LIFT THAT RISES TO THE TOP ALLOWING FOR MAINTENANCE AND REPLACING OF THE BARRELS. THE BAR ALSO BOASTS 4 IN HOUSE DRAFT COCKTAILS, INFUSIONS AND A STATE OF THE ART BEER PROGRAM. TWO HAS GARNERED AN ABUNDANCE OF LOCAL AND NATIONAL ACCOLADES INCLUDING CONDE NAST TRAVELER'S "HOT LIST", BON APPETIT'S "HOT 50 TABLES" AND ONE OF RACHAEL RAY'S "FAVORITE RESTAURANTS" IN THE COUNTRY AS TOLD TO INSTYLE MAGAZINE. NOMINATED LOCALLY YEAR AFTER YEAR AS "BEST RESTAURANT SCENE" AND "BEST PLACE TO TAKE AN OUT OF TOWNER", IT IS NO WONDER THAT GUESTS KEEP COMING BACK FOR DINNER SEVEN NIGHTS PER WEEK AND BRUNCH ON SATURDAY AND SUNDAY. TWO ALSO FEATURES LIVE BLUES WEDNESDAY THROUGH SATURDAY. TWO IS LOCATED DIRECTLY ON THE BELTLINE AND OFFERS AL FRESCO DINING WHICH SECURED TWO'S TITLE OF ONE OF "AMERICA'S BEST OUTDOOR RESTAURANTS" COURTESY OF TRAVEL + LEISURE.
Florida native Michael Bertozzi has been working in restaurants since he was 15 years old. Born and raised in Jacksonville, Bertozzi credits his passion for Southern cuisine to his mother and grandmother, both native Texans. His father, a native of Peru, provided international influence in regards to exploring exotic flavors. However, it took a bit of soul searching to take this influence and find his true calling in the kitchen.
As TWO urban licks' executive chef, he will continue to showcase wood-roasted meats and fishes with the touch of heat that Atlantans have come to know and love.


We are students of Izmir University of Economics, Faculty of Communication. We study in Public Relations and Advertising, Media and Communication, Cinema and Digital Media, Visual Communication Design. Each of us gathered from different classes, from different fields. Because our goal is the same: Look at Like a Children!
WHAT IS THE ''LOOK AT LIKE A CHILDREN''?
Refugee children migrated to other countries due to the civil war in their country. Some of trying to hold on to life with their parents and some of them trying to hold on to life separate from their parents. Before the war in their country, like any child, all they had to do was go to school or play games with friends. Suddenly, their lives became completely different. They had to take great responsibilities to help their families and to live their lives. These children, who are trying to exist in different lands apart from their countries, the fact that they are children is ignored by people and they are exposed to hate speech. ''Look at Like a Children'' is a project developed against these hate speeches.
'' Look at Like a Children '' has two different meanings. One is to look at the world through the eyes of children and the other, like all children, it reminds refugees of children approach with the same kindness and affection. It aims to increase awareness and empathy by using different media, especially social media. In addition, the '' Look at Like a Children '' team tries to make them happy by meeting with the refugee children themselves.


Thanks to the generous donation of $10,000 blackberry bushes will be removed from the downtown Medford section of the Greenway. This effort helps support other efforts to clear the bushes from McAndrews to Barnett.
ThoVKy My brother recommended I might like this blog. He was entirely right. This post actually made my day. You can not imagine just how much time I had spent for this information! Thanks!


FDAP reserves the right to interview any applicant if it is judged that an interview is required to complete the accreditation process.
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FDAP does not return applications so please save a copy for yourself prior to sending the application.
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text:
Coming Home – Rest Stops On The Road in Tennessee and Virginia.
Blog, Touring
9 to 5, Coming Home, On The Road, Rest Stops, RKVC, Romantic pop rock, Tennessee, tour vehicle, traveling, Virginia
Coming Home – Rest Stops On The Road in Tennessee and Virginia. The Rod Kim & Vince Cirino Self Deprecating RKVC Pop Rock Pop Up Videos.
The song "Coming Home" performed on the road at rest stops in Viriginia and Tennessee with the sun rising. Taking a break from the tour vehicle, RKVC performs their song "Coming Home" about working a 9 to 5 and coming home to the love of their life. Coming Home is an older tune from Rod Kim's first solo record that has been requested more often the last few months. Traveling has been a real adventure, but coming home to loved ones make being away worth it. This video for "Coming Home" was filmed by splicing together various performances for rest stops in Tennessee and Virginia while on the road. The romantic pop rock duo, though tired and slightly ill (and not the cool kind) deliver a passionate performance of one of their more raw and honest songs.
Rod Kim & Vince Cirino: Mixing the feel & soul of the singer/songwriter genre with a noncommittal love for modern electronic pop. Though this song doesn't showcase an electronic vibe, the heart and love are definitely there. Though a 9 to 5 can steal someone's soul, the idea of coming home to someone that loves you and has been waiting for you makes the 9 to 5 worth coming home. It's like a modern day fairytale, a knight in shining armor slays the dragon of the work day to eventually make their way to their love. Coming Home is a favorite song amongst the extremely loyal fans and will probably continue to gain traction through the coming years and tour. This performance on the road showcases RKVC's a consistency and passion in a heartfelt and well written love song.
The Self-Deprecating Romantic Pop Rock Duo of RKVC bridges the gap between songs of heartbreak and love without making you want to jump off that bridge. Rod Kim & Vince Cirino: Mixing the feel & soul of the singer/songwriter genre with a noncommittal love for modern electronic pop.
Wooden Airplane – Self Deprecating Humor with Toy Planes and Dance Off
All About You – Invading United Record Pressing How Vinyl is Made.


We're growing rapidly.. and as such our Engineering team is growing too! The team's focus is to provide frameworks, applications and practices to allow agile teams to move faster, detect failures, and to provide key quality metrics to teams and the entire organization.
Champion productivity across the organization by enabling testing and quality capabilities in every team.
Work with cutting edge technologies in AWS, be part of the migration.
Develop and enhance test frameworks in Java, Node, and Python.
Develop + maintain internal applications developed with Java Spring Boot.
Keep up with the newest industry trends and bring recommendations and knowledge of such to the team.
Need to engage with customers, addressing their wants and their needs.
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Cloudformation, lambda, ECS, and code pipeline.
Experience creating tests with Junit, Jasmine, Jest and/or Protractor.
Work within a cutting edge Engineering department that is migrating infrastructure to AWS.
Constant training from top-notch engineers that share knowledge through internal conferences and tech talks.
Ability to attend top technical conferences.
Work on a team that helps a billion dollar company be successful.
Endurance International Group (NASDAQ: EIGI) helps millions of small businesses realize their dreams. We equip small businesses worldwide with products and technology to power their online web presence, email marketing, mobile business solutions, and more.
Endurance's best in class family of brands includes Constant Contact, Bluehost, HostGator, iPage, Domain.com, BigRock, and SiteBuilder, among others. Headquartered in Burlington, Massachusetts, Endurance employs more than 3,800 people across the United States, Brazil, India, and the United Kingdom.


text:
Colo. firm bids big on Barnes & Noble
RACHEL METZ | THE ASSOCIATED PRESS
SAN FRANCISCO — Barnes & Noble Inc., the nation's largest traditional bookseller, said Denver-based Liberty Media Corp. has offered to buy it under a deal valued at about $1 billion.
The bid of $17 a share in cash from the conglomerate chaired by billionaire media mogul John Malone sent Barnes & Noble's stock surging Friday.
The offer values Barnes & Noble shares 21 percent higher than their Thursday closing price of $14.11.
The companies haven't yet signed an agreement, and the deal still is subject to closing conditions, including one that founding chairman Leonard Riggio keep a stake in the company and remain in a management position, Barnes & Noble said. The company said a committee of its board will evaluate the offer.
Liberty Media operates three publicly traded companies — Liberty Interactive Inc., Liberty Starz Group and Liberty Capital Group — through which it runs home-shopping network QVC, movie channel operator Starz LLC and holds stakes in numerous other online, media and communications companies.
Barnes & Noble, which is based in New York, has 705 stores nationwide and 636 book stores run by its Barnes & Noble College Booksellers LLC subsidiary.
The book chain investors know today has its roots in a single New York book store, the Student Book Exchange, which Riggio opened in 1965. By the 1970s, his business had grown to include seven college bookstores, and he bought the then-failing Barnes & Noble bookselling brand and its existing Barnes & Noble book store on Fifth Avenue.
The company put itself up for sale in August in response to pressure from billionaire activist shareholder Ron Burkle. That move came during a proxy battle Burkle waged against the company in opposition to a poison pill plan that limited any single investor to a 20 percent stake. The plan was ratified by shareholders in late 2010.
Traditional book sellers have been facing increasing competition from online retailers and discounters such as Amazon.com Inc. as consumers get increasingly comfortable shopping online and turn to the Web to find lower prices on books and, increasingly, to buy e-books they can read on an e-reader, smartphone or iPad.
The changing climate has already rocked much smaller Borders Group: The nation's second-largest book store chain, which is based in Ann Arbor, Mich., filed for bankruptcy court protection in February. It has since been carrying out plans to close more than a third of its 642 stores, and is reportedly in talks to sell more than half of the remaining stores. Barnes & Noble CEO William Lynch said in February that his company might be interested in purchasing a ''minority'' of those stores.
While Barnes & Noble has had better luck than Borders, its quarterly results have been weighed down recently by large investments in its online and e-reader businesses — markets both companies have turned to as ways to stem the steady decline in book sales in recent years. Barnes & Noble reported growth in its online store in the most recent quarter, and said both this and its bricks-and-mortar stores were helped by sales of its Nook e-reader. The Nook has gained fans but has not managed to match the buzz generated by Amazon's Kindle e-reader.


text:
PetaSuite & PetaSuite Cloud Edition
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PetaGene BioData 2020 keynote on-demand
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Allowing researchers to do the most important
work of analyzing genomic data to improve
health and medicine to everyone
PetaGene started as a small hint of an idea: that a team of Cambridge University PhDs could together devise a novel approach to the problem of genomic data storage. Through "Project PetaGene," a collaboration with the Stegle Group at EMBL-EBI, we researched how to compress huge amounts of genomic data—without compromising data quality.
Three years later, PetaGene is much more than a research project. We took our idea to London's Entrepreneur First incubator and graduated with the program's sixth cohort in 2016. That same year, we won Best of Show for our PetaSuite compression tools at Bio-IT World's annual conference in Boston, beating out 46 competitors from 190 total exhibiting companies. Now, we're a full-fledged company with a suite of products that do what we hoped they would when we began our research at the University of Cambridge: compress genomic data up to 6x, without affecting the quality of the data. Beyond the awards and accolades, we're deeply committed to the motive that inspires PetaGene daily: reducing the size and associated storage cost of genomic data, so it can be more readily accessed and analyzed.
Why is accessing genomic data important? Genome sequencing promises abundant medical benefits. It can offer researchers insights on the genetic origins of certain diseases and enable them to potentially uncover new treatments; can allow patients to practice "precision medicine," in which understanding their specific genetic composition enables them to make better, more precise decisions about their health; and can be stored and analyzed as it accrues, offering long-term research opportunities and solutions to health concerns.
Despite these myriad benefits, the storage cost associated with genome sequencing—which produces a huge volume of data—can be prohibitive. While DNA sequencing has itself become more affordable (less than $1,000 today vs. $300M when it was first introduced in 2001), storage costs have risen. One thousand petabytes of genomic data are already being stored worldwide, and the aggregate cost of genomic storage is expected to grow from $0.5B today to $5B by 2021.
That's where PetaGene comes in. Our products reduce the footprint of genomic datasets in FASTQ and BAM by up to 6x while preserving genotyping accuracy and reducing hardware storage costs. We've worked hard to make integration seamless, with no need for a separate mount or volume. Our fast transfer speeds and open access allow researchers to collaborate easily, sharing PetaGene-compressed files quickly and efficiently.
We've created these products so researchers can do the most important work of analyzing genomic data to improve health and medicine for everyone. That's why we're committed to doing what we do—and we'll keep working to make accessing genomic data faster, more efficient, and more cost-effective.
Dan Greenfield, Co-Founder and CEO
A Cambridge University PhD with a Masters in Bioinformatics, Dan has experience leading teams in Silicon Valley to build groundbreaking new products. His PhD was awarded a prize for the top dissertation in the UK by the British Computer Society.
Vaughan Wittorff, Co-Founder and Chief Commercial Officer
A Cambridge University PhD, Vaughan has significant experience in inventing technology and commercializing it in the private sector. He was formerly a Senior Lecturer in Electrical Engineering at Curtin University of Technology, and long-term Visiting Fellow at Cambridge University in Computer Science and Technology.
PetaGene
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TKXS corporate controller Lindsay Huebler joined the company in 2018.
As corporate controller, I am the gatekeeper for all things financial here at TKXS, including financial statements, reporting, the budget process, payroll and benefits.
2. What drew you to this business?
Being a corporate controller was always my career goal. But when I had the role at another company, what I really wanted was a mentor who could help me visualize what the next level looked like and help guide me there. A mutual contact set up an interview for me with Thad Armbruster (TKXS' president & COO) a little over a year ago, and I walked away from the interview knowing I really wanted to be a part of this company. I like Thad's vision. All the owners are passionate about the company and where it is going. I had never worked for a company so focused on its mission and values. You could just sit in the lobby and witness all five values in action. I wanted to work for a company like this–a company I could believe in.
3. What advice do you wish you'd been given early in your career?
4. What do you want people to know about TKXS?
This is an incredible place to work. I've had the privilege of hiring people from other companies – and they all agree that TKXS is 180 degrees away from any other place they've worked – an incredibly caring environment that is also very successful from a business standpoint. I've never seen anything like it.
5. If we had a billboard outside our offices, what would it say?
We lead by example. We live our values here, every day.


Dilip Kumar, its Chief Projects Officer, announced the companys entry into the nations power sector in a statement made available to the News Agency of Nigeria (NAN) in Port Harcourt on Sunday.
He said that FEDCO had partnered the Port Harcourt Electricity Distribution Company (PHED) with focus to tackling operational requirements in the nations electricity distribution sector.
FEDCO has prioritised adoption of information technology solutions to modernise, integrate and secure its systems with a view to serving customers cheaper, continuous and reliable power.
The company achieved this through the successful launch of its indigenously developer IT solutions in the form of DL Enhance.
Kumar said the DL Enhance system offered solutions such as customer oriented modules and suit of feature rich (sic) solutions all designed to assist PHED in its operations.
The DL Enhanced Series is a comprehensive state-of-the-art integrated solution developed by and for domain experts in the business of electricity distribution.
It is designed for the three processes of revenue management including Meter Reading, Bill Distribution and Collections with completely integrated fast and robust prepaid recharge system.
In addition, the system is designed to meet the local requirements, standard operating procedures and all regulatory requirements of the Nigerian Energy Regulatory Commission (NERC), he said.


text:
Theme Issue 2022: Health Natural Language Processing and Applications (CHIP) (26) Electronic Health Records (747) Clinical Information and Decision Making (855) Natural Language Processing (470) Clinical Informatics (514) Decision Support for Health Professionals (697) Viewpoints and Perspectives (364)
Published on 3.1.2023 in Vol 11 (2023)
Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/37805, first published March 08, 2022 .
Practical Considerations for Developing Clinical Natural Language Processing Systems for Population Health Management and Measurement
Suzanne Tamang 1, 2 ; Marie Humbert-Droz 1 ; Milena Gianfrancesco 3 ; Zara Izadi 3 ; Gabriela Schmajuk 3 ; Jinoos Yazdany 3
Article Authors Cited by Tweetations (18) Metrics
Suzanne Tamang1,2, PhD ;
Marie Humbert-Droz1, PhD ;
Milena Gianfrancesco3, PhD ;
Zara Izadi3, PhD ;
Gabriela Schmajuk3, MD ;
Jinoos Yazdany3, PhD
1Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, United States
2Department of Veterans Affairs, Office of Mental Health and Suicide Prevention, Program Evaluation Resource Center, Palo Alto, CA, United States
3Division of Rheumatology, University of California, San Francisco, San Francisco, CA, United States
Jinoos Yazdany, PhD
10 Koret Way, Room K-219
Email: jinoos.yazdany@ucsf.edu
Experts have noted a concerning gap between clinical natural language processing (NLP) research and real-world applications, such as clinical decision support. To help address this gap, in this viewpoint, we enumerate a set of practical considerations for developing an NLP system to support real-world clinical needs and improve health outcomes. They include determining (1) the readiness of the data and compute resources for NLP, (2) the organizational incentives to use and maintain the NLP systems, and (3) the feasibility of implementation and continued monitoring. These considerations are intended to benefit the design of future clinical NLP projects and can be applied across a variety of settings, including large health systems or smaller clinical practices that have adopted electronic medical records in the United States and globally.
JMIR Med Inform 2023;11():e37805
clinical natural language processing; electronic health records; population health science; clinical decision support; information extraction
Natural Language Processing (NLP) has the potential to improve the delivery, quality, and safety of health care [1-7]. There have been numerous research applications, including the extraction of disorders, drugs, and procedures. Moreover, NLP methods have automated the extraction of information that is likely to be undercoded or not coded in a patient's record, such as the severity of a disorder, their functional status, or social determinants of health [4,6-8]. However, examples of health systems operationalizing clinical NLP tools for real-world clinical decision-making, as well as population health management and quality measurement, are limited. This is a missed opportunity to turn rich, unstructured data into structured information that can be used for quality and performance initiatives within a health system or a professional field, or to make national-level comparisons [2,9-12].
To address the challenges translating research tools to clinical practice, we present practical considerations for NLP system stakeholders that can be used to position an early-stage research project for use in real-world decision-making and to eventually demonstrate institutional value. Our practical considerations are informed by prior literature and reports that describe a chiasm rather than a synergy between clinical NLP research and clinical practice. For example, Wen et al [13] share the Mayo Clinic's Desiderata for the implementation of an NLP development delivery platform derived from 2 decades of implementing clinical NLP in their health system. Lederman et al [14] describe how existing clinical NLP systems "have delivered marginal practical utility and are rarely deployed into health care settings" and call for a new paradigm of clinical NLP research for real-world decision support. Similarly, Newman-Griffis et al [15] call for a new paradigm and general principles for clinical NLP research that are focused on challenges posed by application needs and describe how these challenges can drive innovation in basic science and technology design. Referring to artificial intelligence systems in medicine more broadly, Topol et al [16] have also observed that "deployment of medical AI systems in routine clinical care provides an important yet largely unfulfilled opportunity". We also draw from our own collective experience developing clinical NLP systems for research studies and in an operational capacity.
Our practical considerations can be used to support the development of applications that can push forward advances in clinical medicine right now. We also assess the current landscape of Clinical NLP tools and techniques on our adjoining public GitHub site, which can be updated by the research community as clinical NLP technologies evolve [17].
Practical Consideration #1: Are Data and Compute Infrastructure Ready for NLP?
"Garbage in, garbage out" refers to low-quality data, or "garbage," that can result in misinformation. It was first used by US Army scientists to provide the intuition that computers cannot think for themselves, and that "sloppily programmed" inputs inevitably lead to incorrect outputs. Although this saying is over a half century old, it applies even more today, when powerful computers can record large amounts of data that are not fit for the intended use in a short amount of time.
Key questions that will help to determine NLP readiness of a new clinical corpus includes the following: (1) Are notes and note metadata reported in a timely way and with reasonable quality? (2) Is the unstructured free-text data ready for NLP techniques (eg, can the data be used to extract clinical concepts with an accuracy that is fit for the indented use)? And (3) Are the NLP algorithms feasible to execute in the production environment?
Assessing the quality of textual data—or "Data Readiness"—confronts on the problem of data quality by providing empirical findings about syntactic and semantic aspects of a clinical corpus as well as the associated note metadata such as patient identifiers, the date and time of the note, and the type of note. We define "quality" within the context defined by Kahn et al [18] where three dimensions are considered, including plausibility, conformance, and completeness. The results of a Data Readiness assessment help to predict the difficulty of building an NLP system for those data. The quality of free-text data can vary significantly between different note types within the same or across different electronic medical record (EMR) systems. For example, discharge summaries typically contain complete sentences and clearly demarcated sections. By contrast, intensive care unit (ICU) progress notes typically contain large quantities of digits that are not explicitly labelled as to whether they are vital signs, ventilator settings, or any of the many other quantitative measures that are monitored in critically ill patients. ICU progress notes also frequently contain large amounts of information in just one or two grammatically unstructured sentences. Ambulatory progress reports can range from a few sentences to longer documents with standardized formats.
In some cases, data sets that do not initially appear to be ready for NLP on an intended task can be further processed or sampled so that the data are more amenable to their intended use. For example, a data source can be preprocessed to remove notes that do not fit predetermined plausibility criteria, such as the known range of system availability to identify notes that have a plausible date, or notes that do not have an indicated date. However, this may not always result in data that are ready for NLP; in these cases, investigators should work with an organization leadership to improve data collection before undertaking an NLP project.
The institutional nuances of EMR clinical documentation processes require clinical NLP systems developed at other institutions to be customized to a new local data set. This uses specific preprocessing steps related to the provenance and structure of the source data. In prior work funded by the Agency for Healthcare Research and Quality that was based on the Rheumatology Informatics System for Effectiveness (RISE) registry, we found that simple summary statistics on note length in characters and words ("tokens") were helpful to assess the quality of clinical notes from rheumatology practices across the United States [12]. The RISE registry began operation in 2014, and the free-text extraction covered the period between 2014 and 2018. It combines data from over 260 ambulatory outpatient rheumatology practices that collectively use more than 20 different EMR products. To assess the data readiness of RISE for health services research and to better understand the epidemiology of chronic rheumatic diseases, we first used note metadata. For example, we calculated the number of unique clinical notes recorded by year, as indicated by the time stamp of the patient note. Unique notes were determined by each entry of a textual document within the RISE database. We found that many notes had an invalid timestamp, with dates as early as 1800 and as far out as 8018. This suggested an opportunity to improve the quality of these data. We also found that simple summary statistics describing the textual data helped determine the potential informativeness of RISE for scientific and practical applications. Table 1 suggests that RISE contains many relatively short patient notes (mean of 34.57 tokens in 2018) as well as some longer, more traditional patient notes and letters (SD 203.01 tokens). These types of summary statistics are an important first step in NLP data readiness assessments.
Table 1. Mean, SD, minimum, mode, and maximum note lengtha and word countb for free-text patient Rheumatology Notes submitted to the American College of Rheumatology's data registry, by year.
Year Note count Length of note Word count
Mean (SD) Minc Mode Maxd Mean (SD) Min Mode Max
2010 891,837 96 (353) 1 17 18,774 16 (54) —e 2 2549
2011 1,238,711 128 (554) 4 17 40,295 20 (80) 1 2 5713
2014 5,394,083 209 (1069) 1 19 614,356 31 (160) — 2 107,498
2015 7,715,894 211 (1547) 1 19 2,179,227 31 (224) — 2 375,620
2016 9,812,735 233 (1356) 1 19 425,503 34 (186) — 2 75,844
2017 11,685,000 242 (1468) 1 19 570,721 35 (204) — 2 100,311
Total 50,222,840 205 (1271) 1 19 2,179,227 30 (180) — 2 375,620
aPlease note that 2018 is a partial year. Note length is indicated by non–whitespace characters and symbols.
bWord count was estimated after deidentification of the Rheumatology Informatics System for Effectiveness corpus.
cMin: minimum.
dMax: maximum.
eNot available.
To assess the readiness of data for specific linguistic analysis tasks, such as part-of-speech tagging or named-entity recognition, there are a variety of other descriptive statistics based on corpus linguistics that can be used to assess the quality of textual data. Some of these focus on gross characteristics of the data, such as the extent to which documents have clearly identifiable sections and the nature of the data in those sections. For example, lists such as diagnoses and medications usually have relatively clear boundaries, while family and individual medical histories may not. The presence or absence of sentence boundaries, as well as the length of sentences, are also important predictors of the effort required to build high-performing language processing tools. Other descriptive statistics assess textual data on the level of individual words. For example, textual genres with high levels of repeated word use (eg, fever and pain) can be easier to process than textual genres with high levels of words that only appear once (eg, misspellings and typographic errors).
In addition to data that are ready for NLP, automated information extraction algorithms require infrastructure that will allow for the efficient processing of large volumes of new patient notes. There must be discussions at the design phase of the project to ensure that any research products can be operationally tested, and if warranted, translated to operational infrastructure. It is also important for the product to be updated and maintained if being used longitudinally with routine updates of notes.
If a project has no feasible pathway to operationalize the NLP system for real-world decision support, it might be possible that new resources, including institutional computing infrastructure, could be recommended and acquired.
Practical Consideration #2: What are the Incentives for Adopting the NLP System?
Key questions that will help determine if the proper incentives are in place to support a Clinical NLP system are as follows: (1) will the NLP help to address an existing clinical need? (2) is there support from clinical leadership for the ongoing use of the NLP system? and (3) is there a financial incentive to adopting the NLP system?
Reporting from structured data has been the mainstay in health care practice for decades. The Sentinel active surveillance system for medical products and Observational Medical Outcomes Partnership (OMOP) initiatives helped to pioneer the use of common data models to support regulatory initiatives [19,20]. Building on OMOP's common data models, the Observation Health Data Science Initiative's extension has extended the OMOP schema to incorporate unstructured data with the "NOTE" and "NOTE_NLP" tables. It is likely that EMR databases will become even more powerful for regulatory initiatives when they can jointly leverage various data modalities such as patient notes or images for the purpose of improved patient care. However, in the absence of a specific clinical need that a system is designed to address, and without the proper incentives to use the system, it is unlikely that a system will be adopted for clinical uses such as decision support, regardless of performance on a research task. A successful system for population and precision health must be innovative, pragmatic enough to be deployed in a production environment and directly aligned with organizational incentives and clinical leadership's priorities. It should support interoperability but also allow for customization to the nuances of different health systems. We discuss some of these challenges in the next section.
In cases where there is little or no organizational incentive to adopt a clinical NLP system, it is unlikely to succeed past the research phase. Therefore, working with leadership to identify the potential value to a health system and finding possible incentives to adopt such a system are important first steps.
Practical Consideration #3: Feasibility of Implementation and Evaluation
Key questions that will help to determine the feasibility of implementing and evaluating a clinical NLP system include the following: (1) What is the task (ie, clinical need) that this system seeks to address? (2) Are the clinical concepts of interest captured in structured data? If so, are there limitations to what can be extracted? (3) If NLP is justified, are simple NLP techniques enough or are more complex algorithms warranted? (4) Can the Clinical NLP tool be developed and implemented in a reasonable timeline to fulfill stakeholder needs? (5) What are potential sources of bias, considering factors such as the NLP approach, the data used to train the NLP tool, and the population to which it is applied?
An important early consideration is regarding the target population. In cross-validation over random folds, models are trained and tested over the same population. However, in practice, models are often developed in a training data set but applied to novel data that may originate from a different underlying population of patients or clinicians. Differences in clinical practice and workflow patterns, as well as lack of homogeneity in clinical language (as described above), can have large impacts on the transportability of models from where they were developed to a given target population. This is important to factor into the training assessment (eg, being aware of overfitting) and possibly also into model development. If an available external test set exists that represents the target population, it should be tested as part of the model development process to ensure that the NLP tool is portable and externally valid. Ideally, performance metric reporting should be required for all tools meant to be transportable outside of their training corpus.
There are multiple strategies for mitigating bias and improving portability of NLP tools. One source of bias may arise from the specific type of note used to develop a model; for example, an NLP tool developed only on ICU notes, pathology reports, or notes within a certain specialty may not generalize to other note types or clinical settings. Therefore, different note types should be incorporated into the training corpus, if in fact, the target corpus is intended to involve multiple types. Additionally, as previously described, incorporating a secondary data set that represents the target population for testing, apart from the primary data set used for training, can help ensure that the model is transportable and performs well across health care settings, EMRs, and patient populations.
To evaluate model performance, one must decide at which level the assessment should occur, that is, at the mention, document, or patient level. NLP models can be evaluated by their precision (positive predictive value), recall (sensitivity), specificity, F1-score (harmonic mean of precision and recall) and overall accuracy compared to a "gold-standard" test set of reviewed text [5,9]. However, the text-specific evaluation may not be as important as the document or even patient-level performance, especially if multiple mentions per patient occur, or structured data fields are being incorporated into the evaluation in conjunction with NLP annotations. Therefore, although at the mention level, the NLP model may correctly identify a patient as positive, it may be that it is only when combined with the additional information (other mentions, lab results, etc) that the output and model performance are clinically important.
As important as model performance at the time of development is, more crucial may be the model performance over time. Validation of NLP models is key both retrospectively and prospectively, as data change longitudinally. It is important for models to be evaluated continually to determine whether they should be fine-tuned and updated, and whether any biases exist. For example, this may involve updating rule-based code to reflect changes in language representation or reevaluating or redeveloping deep learning–based NLP models.
If a clinical NLP system does not address a known and ideally high-priority clinical need, it is less likely to be adopted into practice. However, it may be possible to adapt the system to address a need identified by organizational leadership. If it does not initially show good performance, continued development may help to improve the clinical systems accuracy, especially if linguistic annotation data can be generated and made available for training a better model. Lastly, in some cases where additional expertise can be used for a project, it may be possible to meet a project deadline that would otherwise not be possible. Importantly, having a strategy, including a business plan, for maintaining deployed models is important to ensuring that their clinical application is sustained.
The Potential Role of NLP in Real-World Decision Support
NLP has the potential to improve population health outcomes in the United States. For example, in the inpatient care setting, NLP systems could reliably identify individuals with symptoms of diarrhea reported in progress notes and feed these data into algorithms for Clostridioides difficile testing. Inpatients with falls documented in clinical notes could trigger alerts to discontinue sedatives or narcotics. In the outpatient setting, NLP can be used to assess the severity of a disease or a postoperative complication. The NLP of free-text patient notes also creates opportunities for national, routine quality and performance measurement, which can support improvement in the value of health care delivered to patients at highest risk for poor outcomes [9-12,21-23]. As health systems across the United States move toward whole-person care paradigms, NLP systems can also be used to identify important clinical decision support factors that are undercoded or altogether absent from structured data sources in patient records, such as the presence of behavioral, psychosocial, and economic risk factors.
Predictive analytics is another area where incorporating clinical text has the potential to improve population health [5-7,24]. Most models for population-level risk stratification that use health care data have exclusively relied on structured data, but several groups have demonstrated that in certain domains, adding information from clinical text can improve performance. Studies in this area reflect a wide range of tasks from predicting hospital readmissions to identifying patients at risk for suicide [2-13,17,21,22,24,25]. Such models can be used operationally to more accurately target a subset of a population for specific interventions designed to address modifiable risk factors.
Applications of NLP to streamline and facilitate quality and safety reporting are also emerging [9-12]. Federal reporting of quality and safety measures often places considerable burden on clinicians, sometimes requiring duplicate entry of similar concepts in the text of clinical notes as well as in structured fields that can be queried to calculate performance. Reliable extraction of relevant information from clinical notes would not only alleviate burdensome data entry but also greatly expand the types of concepts included in reporting programs. For example, guidelines in rheumatology support the routine collection of disease activity scores for patients with rheumatoid arthritis, but not all EMRs have structured fields to input these scores. Electronic quality measures that extract this information automatically from structured fields might miss scores that are documented only in clinical notes. NLP could be used to extract these scores and improve the validity and reliability of such quality measures[9-12].
While these and other applications of NLP have the potential to improve health care and population health, the successful deployment and dissemination of these applications has been limited. Given these barriers, how should the field move forward? In addition to our three considerations, we think it is critical that multiple stakeholders provide input from the start of NLP projects. Practicing clinicians can ensure the focus of the work is clinically relevant, fulfills an unmet need, and is aligned with current clinical workflows; clinical informaticians can provide insight into whether data systems are available to scale valid NLP algorithms, and health care administrators can lend insight into IT resources required and the feasibility of scaling and sustaining systems. Until there is stakeholder alignment and investment in a project, impact and scalability are likely to be limited. Similar to many new technologies in medicine, alignment often requires the development of the NLP program as a value proposition that either clearly impacts operational efficiency, revenue, quality and safety, or patient outcomes. Moreover, stakeholders need to be integrated into the software development life cycle to ensure the product's ongoing implementation is successful.
The analysis of unstructured free-text patient data enables new ways in which scientific questions can be studied and health care can be delivered. Although such uses are promising, leveraging the clinical text data collected in the EMR and using these data in health care operations are not without substantial caveats. Opportunities to better align state-of-the-art systems developed by researchers to support the measurement of patient-reported outcomes and to support high-quality health care delivery can likely lead to improved outcomes. With a focus on designing practical applications that are aligned with clinical requirements and organizational incentives, the considerations listed here can be used to design a project-specific checklist for a variety of stakeholders. We also summarized the procedures for considering appropriate use of NLP in health and survey the current landscape of Clinical NLP tools. To support future work in this area, we have provided software and data set summaries, license, and other access requirements on our adjoining GitHub site, which we hope will serve as a continuously updated resource for the research community as technologies evolve.
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Humbert-Droz M, Izadi Z, Schmajuk G, Gianfrancesco M, Baker MC, Yazdany J, et al. Development of a Natural Language Processing System for Extracting Rheumatoid Arthritis Outcomes From Clinical Notes Using the National Rheumatology Informatics System for Effectiveness Registry. Arthritis Care Res (Hoboken). Preprint posted online March 14, 2022. [CrossRef] [Medline]
Wen A, Fu S, Moon S, El Wazir M, Rosenbaum A, Kaggal VC, et al. Desiderata for delivering NLP to accelerate healthcare AI advancement and a Mayo Clinic NLP-as-a-service implementation. NPJ Digit Med 2019;2:130 [FREE Full text] [CrossRef] [Medline]
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Kahn MG, Callahan TJ, Barnard J, Bauck AE, Brown J, Davidson BN, et al. A Harmonized Data Quality Assessment Terminology and Framework for the Secondary Use of Electronic Health Record Data. EGEMS (Wash DC) 2016;4(1):1244 [FREE Full text] [CrossRef] [Medline]
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Capurro D, Yetisgen M, van Eaton E, Black R, Tarczy-Hornoch P. Availability of structured and unstructured clinical data for comparative effectiveness research and quality improvement: a multisite assessment. EGEMS (Wash DC) 2014 Jul 11;2(1):1079 [FREE Full text] [CrossRef] [Medline]
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EMR: electronic medical record
ICU: intensive care unit
NLP: natural language processing
OMOP: Observational Medical Outcomes Partnership
RISE: Rheumatology Informatics System for Effectiveness
Edited by T Hao; submitted 08.03.22; peer-reviewed by H Mehdizadeh, JD Posada Aguilar; comments to author 08.07.22; revised version received 02.09.22; accepted 09.11.22; published 03.01.23
©Suzanne Tamang, Marie Humbert-Droz, Milena Gianfrancesco, Zara Izadi, Gabriela Schmajuk, Jinoos Yazdany. Originally published in JMIR Medical Informatics (https://medinform.jmir.org), 03.01.2023.
Tamang S, Humbert-Droz M, Gianfrancesco M, Izadi Z, Schmajuk G, Yazdany J
JMIR Med Inform 2023;11:e37805


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Personal statement: I am self-employed so have the flexibility of time to be able to juggle work with governor business and meetings. I offer commitment and am 100% behind the ethos of the school. I have always wanted to help, in any way possible, the schools my children have attended. I want every child to be able to have a good education.
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Palmdale, CA (93550)
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California Republican Rep. Duncan Hunter, (center) walks towards federal court Tuesday, in San Diego. Hunter said in a TV interview that aired Monday he plans to plead guilty to the misuse of campaign funds at a federal court hearing Tuesday in San Diego.
Former prosecutor says Hunter got 'great' deal
By JULIE WATSON Associated Press
SAN DIEGO — California Rep. Duncan Hunter pleaded guilty Tuesday to a single charge of conspiring with his wife to use at least $150,000 in campaign funds for personal expenses under a plea deal that a former federal prosecutor called "great" for the congressman who had faced 60 counts.
The six-term Republican showed no emotion in the courtroom when he changed his plea to guilty and admitted he and his wife Margaret misused at least $25,000 in campaign money every year from 2010 to 2016. The charge carries up to a five-year sentence, but the deal calls for prosecutors to recommend much less when a judge sentences him in March.
Former prosecutor Jason Forge said under the terms of the deal it's likely Hunter will serve about a year in prison and perhaps less.
"I think if you decide to do a high-profile public corruption case, you have to set up an impervious example and they fell far short of this with this plea agreement," said Forge, who in 2005 prosecuted another San Diego-area congressman, Randy "Duke" Cunningham, in one of the biggest bribery scandals in congressional history.
"Ï would rather go down fighting than agree to this," he added. "He got a great deal."
Prosecutor Phillip Halpern defended the agreement, saying it held Hunter accountable.
"Appropriately today's plea is to the major count of the indictment and effectively puts an end to his political career"," he said. "Mr. Hunter now faces resignation, disgrace and imprisonment."
Hunter said he and his wife dipped into the election funds between 2010 and 2016 more than 30 times and falsely reported the expenses as campaign related from their daughter's birthday party at the posh Hotel Del Coronado to an outing with friends at a French bistro.
"I failed to monitor and account for my campaign spending," Hunter, 42, said outside the courthouse.
He promised to discuss his future later and refused to answer questions about when he would leave the congressional seat he has held for more than a decade.
An early supporter of President Donald Trump's 2016 election bid, Hunter is the second Republican congressman to plead guilty to federal charges this year.
Accompanied by his father, the former combat Marine who served in Iraq and Afghanistan left the courthouse to jeers of "Lock him up!"
Hunter's pending departure will mark the end of a political dynasty in Southern California's most Republican district. His father represented the district for 28 years before Hunter's 2008 election.
For more than a year, Hunter had insisted that criminal charges against him and his wife were the result of a conspiracy of the "deep state" meant to drive him from office in Democrat-dominated California.
Halpern noted Hunter's honorable military service and his family's place in the 50th congressional district. But he had a sharp rebuke for the congressman's claim that he was targeted because of politics.
"No figure, regardless of what office they occupy, should be allowed in this country to cry witch hunt or fake news and attempt to deflect their criminal wrongdoings," Halpern said.
Halpern said he would seek a minimum of one year in jail for Hunter.
Prosecutors agreed to recommend a sentence of eight to 14 months, taking off time because of his military service in war zones and unspecified medical conditions. A judge will ultimately determine his sentence and could impose the maximum of five years.
Hunter and his wife were initially charged with 60 criminal counts and prosecutors accused them of spending about $250,000 in campaign funds including for family vacations to Italy and Hawaii, private school tuition for their children, airline tickets for their family's pet rabbit.
They said the couple was broke and bankrolled their lives with the campaign money.
Prosecutors also revealed Hunter spent some of the money on romantic relationships with lobbyists and congressional aides.
His wife accepted a plea deal in June. In that deal, prosecutors indicated they would not seek a sentence longer than eight months, though Halpern said Tuesday her cooperation helped the prosecution and they had not determined if they will seek any jail time. She also faces a maximum of five years.
Hunter told San Diego TV station KUSI in an interview that aired Monday that a trial would be tough on his three children. He said he hopes his wife is spared jail time.
In October, former four-term Republican Rep. Chris Collins of New York pleaded guilty in an insider trading case, a day after he resigned from Congress.
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Lancaster, Palmdale values are high (6)
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Bill could help commuters, traffic (1)
Head-on collision leaves one dead (1)
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Хадыяха:
 Хадыяха (приток Надыма) — река в Надымском районе Ямало-Ненецкого АО.
 Хадыяха (приток Полуя) — река в Приуральском районе Ямало-Ненецкого АО.
 Хадыяха (приток Саваяхи) — река в Надымском районе Ямало-Ненецкого АО.
 Хадыяха (приток Янгиёгана) — река в Приуральском районе Ямало-Ненецкого АО.

См. также
 Левая Хадыяха — река в Надымском районе Ямало-Ненецкого АО.
 Правая Хадыяха — река в Надымском районе Ямало-Ненецкого АО.