Ella Rhodes reports from a conference at UCL.
A truly unique conference, which set out to explore alternative ways of communicating, sharing and assessing suffering, was held at University College London. Encountering Pain emerged after a three-year interdisciplinary project at UCL called 'Pain: Speaking the Threshold' which assessed the value of images and image-making processes to the management of chronic pain.
I was there for the first day of the conference, which truly put clinicians, patients and academics on the same level and opened up fascinating discussions. Pain: Speaking the Threshold drew on a previous project Face 2 Face, a collaboration between artist Deborah Padfield and facial pain consultant Professor Joanna Zakrzewska and patients and staff from University College London Hospitals (UCLH). It focused mainly on facial pain but also explored the impact of visual images on medical dialogue in more detail.
During Face 2 Face, sufferers worked with Deborah Padfield to co-create images of pain, which were subsequently piloted by other patients in NHS clinics. The conference was a chance to share the results with patients and clinicians involved in the study, to hear the testimonies firsthand of those who co-created the photo cards, based on their experience of pain, and to bring together high-profile medical professionals, psychologists, a linguist, historian and neurobiologists to speak about pain and the projects alongside poetry, dance and performances.
Professor Zakrzewska (UCLH), a doctor with a specialism in facial pain, explained that pain could often be difficult to express using language alone, and with 14 million people in the UK suffering from chronic pain it was an important area to address. The photo cards created during Face 2 Face feature visual metaphors, such as an electrical wire sparking or a leg with a heavy weight tied to it, giving patients a new way to explain their pain to medical professionals. Zakrzewska explained that the images encourage the exploration of different aspects of pain between patients and the person listening to their story.
Padfield said she was initially encouraged to use art to express her own pain by her GP and subsequently wanted to assess whether this approach could be helpful to other patients. She said, after meeting pain specialists, and in particular talking to her own pain specialist, Dr Charles Pither, then Medical Director of Input Pain Management Unit, St Thomas' Hospital, she discovered pain's incommunicability was as frustrating for clinicians as it was for patients. Its invisibility and subjectivity make it a difficult thing to capture using objective measures, she added.
In an earlier project, Perceptions of Pain, Padfield collaborated with Pither, where she co-created with patients photos that represented their unique experiences of pain. In 2004 they carried out a feasibility study to see if these images could benefit other patients, and the feedback received encouraged her to look further into the role of images in patient–clinician communication.
This developed during the subsequent collaboration with Zakrzewska, Face 2 Face, which additionally explored patient experiences of facial pain. This kind of pain presents another problem. 'Our faces', Padfield said, 'are often the canvases we use to express pain, but when the face itself is in constant pain these feelings become harder to express in a way which others can read.' One of the strands of this project involved workshops for clinicians and patients to attend together at both UCLH and the National Portrait Gallery to encourage them to share their experiences outside a clinical context.
Padfield worked with facial pain patients to co-create pain photos. A group of these were integrated with a selection of those from Perceptions of Pain, compiled into a pack of 54 laminated cards and tested out in real consultations, which were filmed. Ten different healthcare professionals from the pain management teams at UCLH offered to have their consultations filmed. The clinicians saw two patients each without images and two new patients with images, both groups under the same conditions. The filmed consultations and post-consultation questionnaires made up a unique body of material that was analysed during the recent Pain: Speaking the Threshold project by experts from different disciplines.
Professor Elena Semino, Head of Linguistics at Lancaster University, analysed these consultations and compared those in which the photos were used and those where they weren't. She assessed the kinds of language used in the consultations and whether the photos changed the amount of speech used by doctors compared to patients. She found that patients spoke much more than clinicians in consultations where the photos were used. In these consultations patients also described their pain in metaphorical terms. Patients using the photos spoke frequently about their sense of self being worn down due to pain and also disclosed emotional narratives and suicidal feelings. Semino said the photos seemed to encourage people to speak in similes, and from that point more information emerged.
Semino concluded that the use of photos allowed a patient to speak about pain differently as well as increasing references to thoughts and feelings, as well as making it more likely for patients to make personal disclosures, such as suicidal thoughts.
Clinical Health Psychologist Dr Amanda C de C Williams (UCL) steered the audience through an analysis of the non-verbal interactions in the filmed consultations. She said pain was an area of particular interest due to the subjective nature of our experience of it; people bring their own individuality and social role to pain whether as a patient or observer. She found little difference between the general ratings, by both clinicians and patients, about the quality of the consultations as whole; overall these were uniformly quite high. It did emerge, however, that the images seemed to impact on the non-verbal behaviour and in particular more on clinician than patient behaviour.
Williams took a sample of one minute out of every five minutes of each consultation, which were rated by two observers for behaviours around rapport, affiliation, dominance and submission. They saw that patients showed roughly the same level of affiliation whether using images or not, while clinicians showed more positive affiliation when using the images. It appeared patient and clinician behaviour was more attuned in the with-image condition.
After a beautiful dance performance by Anusha Subramanyam, based on the patient experiences used in the project, came a fascinating keynote by Professor Rita Charon (founder and Executive Director of the Program in Narrative Medicine at Columbia and Professor of Medicine at CUMC, New York) on narrative medicine and the talk of pain. Charon coined the term 'narrative medicine' pioneering a new field. Facial-pain sufferers Liz Aldous and Ann Eastman also shared their moving experiences of being involved with the Face 2 Face project and creating images of their own pain, which have since been used by other patients.
He said that many psychologists see the body simply as a taxi for the mind, and in trying to apply psychology to pain many see it through the lens of abnormal psychology. However, Eccleston said, this does not always 'fit' with a person's experience, as those suffering with chronic pain are usually not psychologically disordered in any way.
Eccleston described himself as a 'normal' psychologist, interested in the everyday and usual. He asked whether there was another way to look at pain aside from thinking about mental states or observed behaviour, he said potentially it sits where it can't be pinned down – between mind and action.
The second day saw talks from Professor Joanna Bourke, Dr Preeti Doshi, Professor Maria Fitzgerald, and more.
- Read more in our June 2011 special issue on pain.


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Q: LLVM alias analyzer weird results I'm implementing a pass that uses alias analyzer, specially using the AliasSetTracker. I simply want to output all alias sets in a function.
The pass code is very simple, it runs on functions and it is like this:
virtual bool runOnFunction(Function &F) {
  AliasAnalysis &AA = getAnalysis<AliasAnalysis>();

  AliasSetTracker tr(AA);
  for(Function::iterator i=F.begin();i!=F.end();++i){

    for(BasicBlock::iterator j=i->begin();j!=i->end();++j){
  if(dyn_cast<StoreInst>(j)){
            StoreInst *ai=dyn_cast<StoreInst>(j);
    //errs().write_escaped(ai->getName());
      tr.add(ai);
  }
  if(dyn_cast<LoadInst>(j)){
            LoadInst *ai=dyn_cast<LoadInst>(j);
    //errs().write_escaped(ai->getName());
      tr.add(ai);
  }
}

int counter=0;
for(AliasSetTracker::iterator it=tr.begin();it!=tr.end();++it){
  errs() << "Set " << counter++ << "\n";
  AliasSet *s=dyn_cast<AliasSet>(it);
  if(s->isMustAlias())
    errs() << " set is must alias\n";
  if(s->isMayAlias())
    errs() << " set is may alias\n";
  for(AliasSet::iterator ra=s->begin();ra!=s->end();++ra){

    errs() << ra.getPointer()->getName() << " ";
  }

}
  }
  return true;
}

I test the pass with the following test function implement in hello.cpp:
void testfuncion(int *given){
  int *o,*i;
  o=given;
  i=NULL;
}

I run the plugin using different AA passes e.g.:
clang  -emit-llvm -o hello.bc -c hello.cpp -> compile the test code
./opt -load ../lib/AliasTest.so -globalsmodref-aa -aliastoprolog < hello.bc OR
./opt -load ../lib/AliasTest.so -basicaa -aliastoprolog < hello.bc

In the test function as you can see i and o are not aliases. With globalsmodref, the pass prints may alias.
With basicaa o and i are in separate sets (correctly) but when I change the line i=NULL to i=o in the test function, basicaa still returns separate sets for o and i, globalsmodref says o and i may alias even though it should be must alias. So what am I doing wrong here?

A: I dont think AliasSet *s=dyn_cast<AliasSet>(it); is the right way to get the AliasSets. Use getAliasSets() method instead as shown in the link below.
http://llvm.org/docs/doxygen/html/classllvm_1_1AliasSetTracker.html#a8f3b5f5d7978436b03d3e4b8597d9bc4
Does it make a difference ?

redpajama_set_name: RedPajamaStackExchange


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'Lisa Williams: Life Among the Dead' Returns to Lifetime Television
Lisa Williams: Life Among the Dead Returns to Lifetime Television
Lifetime Television's popular reality series Lisa Williams: Life Among the Dead has been renewed for a second season, it was announced by Susanne Daniels, President, Entertainment, Lifetime Entertainment Services. The show will return this summer.
Lisa Williams: Life Among the Dead explores Williams' claim of her abilities to see and speak with the dead and in some cases possibly transform the lives of the people she meets who are seeking to connect with their dearly departed. Throughout the series, Williams shares stories of people wanting to be reunited with someone from their past, while offering personal observations and insights.
"The outpouring of letters and emails we have received from fans of Lisa, and the show, has been overwhelming," said Daniels. Adding, "We are thrilled that her vibrant and fun-loving personality has connected with our viewers."
Lisa Williams' success comes as no surprise to producer Merv Griffin, whose ability to recognize star quality is legendary. "I just knew the camera would love Lisa's face and that people would be amazed and entertained by her abilities," said Griffin. Adding, "Our office, too, has received a huge number of queries asking when she would be back on the air. We couldn't be happier that the show has performed so well for Lifetime and we look forward to an even more remarkable second season."
Merv Griffin, Raymond J. Brune, Andrew Yani and Yann Debonne serve as executive producers of the series, produced by Merv Griffin Entertainment in association with Kimo Jagger Productions for Lifetime Television.
In each episode of Lisa Williams: Life Among the Dead, cameras follow a typical day in the life of the young clairvoyant. When Williams removes her hat, revealing her signature multi-colored spiky hair, it's her way of showing the spirit world that she is available for contact. Lisa gives readings in her office to scheduled clients and oftentimes to people she randomly meets while about town in Los Angeles. In these meetings, Lisa relays messages that she believes are from the dead to their relatives and friends. The series also observes Lisa at home, with her husband, Kevin, and her six-year-old son, Charlie, who already shows an interest in natural healing and talking with spirits.
Online, viewers can log onto Lifetimetv.com and see exclusive video coverage of Lisa Williams giving readings to strangers on the street and footage from the show. Site visitors will also be able to learn more about Lisa personally through exclusive interviews and family photos. During the first season of Lisa Williams: Life Among the Dead, Lifetimetv.com hosted four live chats where viewers e-mailed Lisa questions directly, which generated more than three times the amount of traffic to the site than usual.
Dont't forget to also check out: Lisa Williams: Life Among the Dead

redpajama_set_name: RedPajamaCommonCrawl


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Hurricanes' Injury Bug Deja Vu
By Mark Shiver October 10th, 2015
Carolina Hurricanes coach Bill Peters must be hearing the immortal words of the late, baseball great Yogi Berra, "It's déjà vu all over again." That's how it must feel for fans as well at the start of another NHL season that again sees a veteran player lost to injury. Defenseman James Wisniewski went down in the early part of the Canes' season opener against the Nashville Predators. It was obvious from watching the initial play where the injury had occurred.
Hurricanes GM Ron Francis announced Friday that Wisniewski will undergo surgery on his left knee after suffering a torn ACL and that the recovery time for the injury is estimated at six months.
Wisniewski was acquired in June from the Anaheim Ducks in a trade for Anton Khudobin. While never considered a high-end defenseman in the league, Wisniewski is a solid veteran player that the rebuilding Hurricanes needed, especially in the locker room. His injury puts the team in an even more serious position of need on the defensive side of the ice, especially since Andrej Sekera is gone.
Filling the Hole
I wrote on June 19 that Justin Faulk needs help. I still believe that is the case for this team. The loss of Wisniewski, who was not looking to be the nightly partner of Faulk, creates yet another hole to fill. It's early, but Peters currently has Ron Hainsey on the back end with Faulk.
Hainsey is a lot like Wisniewski in that he has been around the league a long time and is not regarded as premiere, but solid. He may be able to provide what Peters needs alongside Faulk for the time being, but if it turns out that the duo doesn't have the right kind of defensive chemistry night in and night out, Peters will have to improvise. That is, until the team is able and/or willing to go out and find a top-pair defender to match with Faulk.
Noah Hanifin shows a lot of promise and who knows what his upside is ultimately. I think the sky is the limit for the Hurricanes' first-round pick at this year's NHL Entry Draft. But, he is a rookie, and time will tell whether or not he can truly be consistently relied upon in the same way that Aaron Ekblad distinguished himself last year with the Florida Panthers.
I believe he will, but the immediate need is for a solid, stable blue line and hopefully a continuation of last year's strong Canes' penalty kill. For the moment, Francis has called upon Charlotte Checkers defenseman Danny Biega to fill the hole in the defense.
Biega played 10 games for the Hurricanes last season and had two assists. He also played in 69 games for the Checkers where he notched two goals and 12 assists. The 24-year-old will have to adjust quickly if he is going to make the case that he belongs at this level.
Peters also said that Michal Jordan will be getting lots of ice time as well. In reference to Jordan, Peters acknowledged:
"He should be in the lineup for the foreseeable future."
At 25, Jordan is another young Hurricane that played well at times last season but is likely not ready for nightly prime time. However, he may have to get ready quickly.
All in all, the injury to Wisniewski is a huge blow to a team hoping to have a better season than they have in quite a while. Jordan Staal's broken leg and Jeff Skinner's concussion both happened early last season and contributed to the 0-8 start in the month of October. The Canes and their fans are hoping that the injury bug will not bite again this season.
Justin Faulk
Ron Hainsey


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Theme Park Bits: A Web Series About Disney Superfans, DCA's Secret Bar, Universal's Holiday Parade And More
Posted on Friday, November 30th, 2018 by Josh Spiegel
In this edition of Theme Park Bits:
You can dry off from a soaking ride on Grizzly River Run at Disney California Adventure.
The biggest superfans of all Disney superfans are getting the spotlight on a new web series.
See how Shanghai Disneyland's Treasure Cove could've looked a lot different based on unearthed artwork.
Get ready for Universal Studios Hollywood's first-ever running event.
Learn about the secret bar hidden in plain sight at Disney California Adventure.
The midterm elections had an impact in Anaheim for Disneyland cast members.
The parks of the Disneyland Resort, like any self-respecting theme parks, have water rides. There's, of course, the iconic Splash Mountain, but at Disney California Adventure, if you want to really get wet, Grizzly River Run is for you. This rushing-rapids attraction is one of the park's visual centerpieces; in the past, if you didn't utilize one of the attraction's free lockers, you'd be soaked all day long. No longer! At the beginning of November, Disney introduced full-body dryers in front of the attraction so you can get back to experiencing the rest of the park in no time. These "Wilderness Warming Huts" can fit up to five people, which is fitting, since it'll cost you $5 to use. (I visited the Disneyland Resort after Thanksgiving, and did a double take when I saw people using these dryers up close. It's quite the sight.)
If you think you're a Disney superfan, you might be surprised at how intense the fandom can be. That's the focus on the new Oh My Disney show Disney People. There's one couple who lives in a house designed like the house from Up, and one man who's experienced Radiator Springs Racers at Disney California Adventure more than 10,000 times. (I will here shamelessly plug Happy Place, the book written by my podcast co-host Scott Renshaw, all about Disney fandom, including a section focusing on that RSR frequent rider.) I can consider myself a dedicated fan, but these folks put me to shame.
One of my favorite ways to dig deeper into the history of theme parks is to see the lands that never were, and the lands that nearly came true. Here's a recent example, uncovered by Disney and More, as they explore how the Shanghai Disneyland section called Treasure Cove nearly looked a lot different in its depiction of piratical culture.
It's hard to believe, but Universal Studios Hollywood has not yet followed in the footsteps of its rival Disneyland by holding events for runners. But that's all going to change on May 11, 2019, with the inaugural Running Universal event. This 5K event leads runners through the park, the backlot, and culminates at CityWalk. As a bonus, those irrepressible Minions will be on hand as well. (If you're like me, this would be an impetus for you to run as fast as you can away from the Minions. But you do you.)
There's a secret bar at Disney California Adventure, and it's just out there waiting for you to stop there for a drink or twelve. Need I say more? It's a secret bar! But you don't need to be a member like with Club 33!
Remember the midterm elections that happened just a few weeks ago? For Anaheim, the election meant a great deal for the future of Disney, too. A Disney-friendly mayor was voted in, but a measure designed to raise the minimum wage for workers in and around the parks was passed by voters. The city's Chamber of Commerce president dubbed it "tragic" to pass a measure designed to raise the livable wage for hourly employees at the Happiest Place on Earth, and…sure, "tragic" is a word you could describe for people wanting a better livable wage. I won't use that word. But you can, if you think that's how to approach this kind of thing.
Speaking of politics, if you think it's a smart idea to flash a sign supporting our current president's presumed reelection campaign while you're at Walt Disney World, think again. The, uh, very smart individual above was making sure everyone knew that he supported the president, and for doing so, he's banned from Walt Disney World. For life. He was apparently displeased with how Disney treats the president. (Maybe he's not a fan of the animatronic figure of the president in The Hall of Presidents? You know, the attraction where he's currently the central focus of a specific section? Such poor treatment.) Anyway, this kind of thing is an easy way to get booted out of the park, so maybe aggressively displaying your political preference in a theme park designed for families who arguably don't want to think about politics isn't the best idea.
It's the holiday season, so for theme parks, that means holiday parades. At Universal Studios Florida, they've got the Universal Holiday Parade featuring Macy's, and as Stefon would say, this parade has everything. (Stefon is a Saturday Night Live character, and NBC is owned by Universal. It all ties together.) Parade floats featuring Shrek and characters from Despicable Me? Check. Macy's iconic balloons? Check. More than 220 pounds of "snow machine fluid"? Check. The parade runs through January 6 of next year, so if you're in the neighborhood, find out exactly what snow-machine-fluid-created snow looks and feels like at this parade.
Disney is Killing the Fox Name, Will Use 20th Century Studios and Searchlight Pictures Instead
Disney+ is the Most Downloaded App in America
Upcoming Auction Features Rare Disney Theme Park Props, Posters, and Memorabilia – See the Coolest Ones Here
Get a First Look at Mickey and Minnie's Runaway Railway, Coming to Disney World in March 2020
Theme Parks, christmas, Disney, Disneyland, Grizzly River Run, Holiday, Parade, Trump, Universal


A mock-up carriage from the new Victoria line fleet, due to be introduced from 2009 as part of Transport for London's (TfL's)Victoria Line Upgrade (VLU), is on display at Euston Square Gardens from today.
Between 21 July and 4 August the carriage will undergo market research, after which time there will be public viewing until 10 August.
The Victoria Line Upgrade will provide passengers with safer, more reliable and quicker journeys as faster new trains and an improved signalling and control system are delivered as part of Transport for London's £10bn 5 year Investment Programme.
The market research process aims to ensure that London Underground's (LU) passengers are satisfied with the design of the new fleet proposed by Metronet Rail, the company responsible for the maintenance and renewal of the Bakerloo, Central and Victoria lines.
John Doyle, General Manager of the Victoria line said: "TfL is investing £10bn over the next five years to meet London's transport needs, now and in the future.
"The Victoria Line Upgrade is a key Investment Programme project. Forty seven new, bigger and faster trains will be brought on the line between 2009 and 2013 as part of the Victoria Line Upgrade.
"The new trains will have greater capacity and will run faster. Other improvements to be delivered as part of the Victoria Line Upgrade include an improved signalling system, tracks and control system.
"These improvements aim to deliver safer, more regular and reliable customer journeys with better information provision and accessibility.
"The changes are likely to lead to a 17 per cent increase in peak frequencies and 16 per cent improvement in journey time. The Victoria Line Upgrade is due to be completed in 2013."
Lighting, heating and ventilation systems for passengers.
Metronet Chief Programmes Officer Stephen Hall said: "I believe Londoners will welcome this new breed of train.
"This mock-up will give us good quality feedback on what people think about the improvements they can expect when the new Victoria line trains enter service in 2009."
Results of the market research will be announced in October 2006.


Axar Patel did the star turn as laggards Kings XI Punjab rode on the left-arm spinner's hat-trick to upset table toppers Gujarat Lions by 23 runs in an Indian Premier League (IPL) match here today.
This was the first hat-trick of the ongoing 9th edition of the league.
Invited to bat by Gujarat Lions skipper Suresh Raina, Kings XI Punjab were all out for 154 in the stipulated 20 overs, but restricted the opposition to 131 for 9 in front of their home crowd at the Saurashtra Cricket Association Stadium.
Appointed captain midway into the cash-rich tournament in place of David Miller, Murali Vijay led from the front with a fluent knock of 55.
Patel then spun a web around the Gujarat batsmen and finished with impressive figures of 4/21 in his quota of four overs which included a split hat-trick.
With this win, Kings XI Punjab finally managed to turn things around in what has been a nightmarish campaign so far.
Kings XI Punjab now have four points with two wins and five defeats from seven matches, while the Lions, despite the reverse, stayed at the top with six victories and two losses from eight appearances.
Chasing a modest target, the Lions were off to a poor start, losing the dangerous Brendon McCullum (1) with just 13 runs on the board in the second over. Raina was the next to go, being bowled by medium pacer Mohit Sharma, who also accounted for the wicket of McCullum in a similar fashion. Raina made 18 off 15 balls, hitting a couple of boundaries and a six.
Patel then took centrestage as the 22-year-old slow grabbed the wicket of opener Dwayne Smith (15) with his third delivery.
He then snared Dinesh Karthik and Dwayne Bravo off successive balls - fifth and sixth of the seventh over. Patel returned to pick the wicket of Ravindra Jadeja with the first delivery of the 11th over to complete the split hat-trick.
After sending back Bravo, Patel celebrated by performing the West Indian's 'Champion' jig.


Large Cat House and Run. This unit is very large at 9 feet x 6 feet externally approx House and Run is 8 feet x 4 1/2 feet approx, it has a raised house for easy waist height access. Pull out cleaning trays, Vents, , Sleeping areas, Rear Door, Door on run part. Heavy duty mineral felt roof.


The Boeing 787 capacity varies depending on the model. The 787-8 has a capacity of 224 (3-class). The 787-9 has a capacity of 280 (3-class).
The 787-8 is 186 ft (56.7 m) long and has a wingspan of 170 ft 6 in (52.0 m). The wing area is 3,501 sq ft (325 m2). The wing sweepback of the 787-8 is 32.2 degrees. The airliner is 55 ft 6 in (16.9 m) tall. The fuselage is 18 ft 11 in (5.77 wide and 19 ft 7 in (5.97 m) high. The airliner has an 18 ft (5.49 m) maximum cabin width.
The cargo capacity of the 787-8 is 4,822 cu ft (137 m3) 28× LD3, 8x (96×125) pallets + 2x LD3 or 9x (88×125) pallets. The maximum takeoff weight is 502,500 lb (228,000 kg). The maximum landing weight is 380,000 lb (172,000 kg). The operating empty weight of the 787-8 is 242,000 lb (110,000 kg).
The 787-8 has a cruising speed of Mach 0.85 (567 mph, 490 knots, 913 km/h at 35,000 ft/10,700 m). The top speed is Mach 0.89 (593 mph, 515 knots, 954 km/h at 35,000 ft/10,700 m). The range when fully loaded is 7,650–8,200 nmi (14,200–15,200 km; 8,800–9,440 mi).
The Boeing 787 capacity is bigger than the 787-8. However, many of the specs are the same. The wing area, wing sweepback, height, fuselage dimensions and maximum cabin width are identical with the 787-9. The cruising and maximum speed are also the same as the 787-8.
The 787-9 is 206 ft (62.8 m) long. The wingspan is 197 ft 3 in (60.1 m). The cargo capacity is 11x (96×125) pallets, 6,086 cu ft (172 m3) 36× LD3 or 11x (88×125) pallets.
The maximum takeoff weight of the 787-9 is 545,000 lb (247,000 kg). The operating empty weight is 254,000 lb (115,000 kg). The maximum landing weight is 425,000 lb (193,000 kg). The range when fully loaded is 8,000–8,500 nmi (14,800–15,700 km; 9,210–9,780 mi).
The maximum fuel capacity is 33,428 US gal (126,540 L). The service ceiling is 43,000 ft (13,100 m). The engines are General Electric GEnx or Rolls-Royce Trent 1000.
The Boeing 787 capacity makes it a midsized jet airliner. According to the company, it is their most fuel efficient plane. The 787 is also the first airliner to rely on composite materials for the building process.


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Bank of Canada hikes interest rate to 2.5% -biggest jump since 1998 Social Sharing
Canada's central bank raised its benchmark interest rate by a full percentage point to 2.5 per cent. That's the biggest one-time increase in the bank's rate since 1998.
Report says tax on $1M+ homes could be key to making housing more affordable
An annual surtax on houses valued over $1 million could help reduce housing inequality and cool housing markets, a report says.
Toronto home sales lead to record 2021 despite weaker December
A resurgence in demand for Toronto homes contributed to record residential real estate sales and prices in 2021 despite a dip in December.
A Toronto mall around for over five decades will be completely demolished
Toronto's brick-and-mortar retail landscape has suffered immensely with the rise of online shopping and exponentially more during the pandemic, and it looks like the thirst for new housing could soon bring about the end of a shopping mall that's been a North York staple for over a half-century.
Ontario condo developer suddenly cancels years-long sales deal – unless buyers pay $100K more
The foundation has been poured for Soraya Palma's first home and she's paid most of the deposit. But the 29-year-old says she now has no choice but to walk away from the Barrie, Ont., development.
August home sales down, prices up as supply fell 43%
August home sales slowed from the frenzied pace seen earlier in the year, but market conditions have tightened as supply plummeted by 43 per cent and prices rose yet again
Liberals promise helping hand to first-time homebuyers through loans, grants
Liberal Leader Justin Trudeau says a re-elected Liberal government would help renters become homeowners through $1 billion in loans and grants.
U.S. Housing Boom Rescues More Than 1 Million 'Underwater' Homes
The pandemic housing boom has pulled more than 1 million U.S. homeowners out of a debt trap that many had been stuck in since the great financial crisis more than a decade earlier.
Canada housing market: GTA home sales fall in July but prices remain high
Fewer homes traded hands in the Greater Toronto Area (GTA) in July. But demand remains strong and prices remain out of reach for many first-time buyers.
Residential investment overtakes business in share of Canadian economy: CIBC
Canada's real estate market is such a key economic driver that residential investment recently surpassed business investment in percentage share of the economy.


Tomorrow, Friday 31 August 2018, the Democratic Alliance Youth Leader, Luyolo Mphithi, accompanied by DA KZN Youth Chairperson, Fikani Khubisa, DA Youth Deputy Chairperson, Henning De Wet, uThungulu DA Constituency Chairperson, Sazi Msane, and members of the Provincial Youth Executive will lead young people to register to vote at a local Independent Electoral Commission (IEC) Office at the City of uMhlathuze's Civic Centre.
According to the IEC, KwaZulu-Natal not only has the highest number of incomplete addresses on the Electoral Commission of South Africa voters' roll, but there is also a significant number of potential and new voters who remain completely unregistered. There are over 1 million incomplete addresses for the 5.3 million registered voters in the province.
DA Youth Leader Mphithi will encourage young people to have a voice in this democracy and the upcoming elections. It is only through voting that residents will have a say and choose a government that will put the poor and unemployed youth first.
It's of tantamount importance for us to encourage all South Africans to take full advantage of making use of this life-changing opportunity. The 2019 General Elections is an important one, as it will allow residents to vote for change, change that creates access to real and long-lasting jobs. Change that the DA will build one South Africa for all.


2. Editing your calendar is painful, and feels personal. In the writing world, there's an old maxim for producing great work: "Murder your darlings." It means you have to cut lines or phrases or paragraphs or even chapters that you love, for the sake of the whole. Self-editing feels like you're killing a loved one. But we have to do it anyway—ouch. But otherwise, there's too much bulk and not enough bite in our schedule. If you're going to add something, you have to be willing to subtract something, or else you'll lose everyone.
3. Relationships grow when we give space for them to grow. Youth ministry at its core is all about relationships—an all-in Jesus, working through all-in adults, who love teenagers into an all-in faith. And that progression can't happen if your core team's relationships are strained because the calendar demands are too great.
Block off Sabbath and family: Make sure your calendar reflects at least one day off each week for you and your team members. Also note any known family things such as birthdays, vacations, and extracurricular events. Add at least one flexible day a month—a time where you each go away from the office to be creative, grow in your relationship with Jesus, or whatever is is life-giving to you.
Write down the bare bones black-and-white stuff: List weekly gatherings and other events you were specifically hired or asked to do/oversee. Next to each one, write who will be the point person for that activity or program. Create a rhythm to cycle through key leaders—such as "Six On, One Off" or bi-weekly.
Revisit your values: The mission of God never changes, but certain values emerge more than others each year. For example, you may need to focus on creating a small group of student leaders who will be launching a new outreach at local schools. As a team, clarify any emerging values that will define the upcoming year.
Add events sparingly: Aim for one big event a quarter. Write them down, stare at them, and then discern if you could/should add another event in that same season. As part of that process, look for overlap on everything else you already have on the calendar so you don't overburden everyone.
Prune, and prune again: Make sure every idea makes sense in your overall ministry vision. Shorten meetings if you can. Once a month, skip what you do weekly just so everyone has that extra time to invest into others.


Walleye warriors are continually in search of the next hot bite. Each of us defines the parameters of our own personal paradise. Some seek untapped legions of sag-bellied giants topping 10 pounds. Others envision oodles of eaters eager to inhale whatever we cast their way. The good news is many North American fisheries are flush with booming year-classes, offering something for everyone in settings ranging from the Great Lakes to high desert impoundments. To help you ride this rising tide in 2015, we offer seasonal perspectives on some of the planet's hottest bites.
Canada has long offered standout walleye options. In-Fisherman Contributor and Guide Jeff "Gussy" Gustafson, of Kenora, Ontario, says the north end of Lake of the Woods is as good as it gets right now for trophy fish. "There's probably no better water for taking big walleyes on artificials — think swimbaits and jerkbaits," he says. "Walleyes roam shallow vegetation all summer and are plentiful on main-lake humps as well."
For fly-in fans, he recommends Northwest Ontario's Maynard Lake. "It's a super-productive water on the English River system," he says. "If you want to catch hundreds of walleyes a day, of all sizes, this is the place to go."
Canadian walleye ace Jeff Gustafson says the northern '¨reaches of Lake of the Woods are as good as it gets.
Decorated tournament competitor Keith Kavajecz reminds us that the Bay of Quinte, just off Lake Ontario in eastern Ontario, is no slouch, either, particularly for giants. "September through ice-up is the time to troll big crankbaits for fish suspended over deeper water," he says. "You might only get a dozen bites a day, but they could all be over 10 pounds."
In-Fisherman Editor In Chief Doug Stange says Saskatchewan standouts such as Last Mountain Lake also merit mention when planning Canadian getaways. Others point to mighty Tobin Lake, Lac La Ronge, Diefenbaker, Jan, and countless other hot spots.
For winter-weary walleye fans across the Ice Belt, a number of southern and Midsouth fisheries hold promise for road trips. From select lakes in northern Georgia into North Carolina west to Arkansas, Oklahoma, and Missouri, opportunities for both numbers and sizes of walleyes exist in waters that receive a fraction of the pressure endured by their northern counterparts.
Case in point: In Georgia, state-run walleye stocking to control blueback herring has yielded thriving populations in Savannah River drainage lakes such as Burton, Seed, and Rabun, along with Lake Lanier and Carters Lake. Self-sustaining fisheries also exist in north-Georgia fisheries including Blue Ridge and Hartwell.
In general, action focuses on major spawning areas from February into April. On the Savannah River lakes and Lanier, for example, prime lies are in shallow, rocky, headwater areas. Males weighing 2 to 4 pounds are common throughout this period, whether staging deep, cruising the shallows, or lingering nearby in the early postspawn. Females topping 12 pounds are possible, though they spend less time dallying around the spawning grounds than their suitors.
Tournament organizer and veteran guide Dan Palmer tracks hot bites from Missouri to the Great Lakes.
As is the case elsewhere in the walleye world, top tactics include jigs tipped with livebait or softbait trailers, along with shallow-running crankbaits, swimbaits, and similar 'eye candy. Postspawn fish drift into deeper water, moving into depths of 15 to more than 50 feet, seeking water temperatures of 62°F to 65°F. In some lakes, such as Lanier, the fish scatter widely, making fishing challenging. Other lakes, like Tugalo and Yonah, yield good fishing year-round.
Farther west in Missouri, March is a top time to target spawn-minded walleyes in reservoirs like 24,900-acre Stockton Lake. This impoundment offers distinct lake- and tributary-spawning populations, spreading opportunities from the rock-lined face of the dam to rivers such as the Big Sac and Turnback Creek, which traditionally receive major pulses of spawning fish. Wet springs are a wild card, spreading walleyes across numerous inflows.
As a testament to the fishery, the Cabela's Masters Walleye Circuit has broken from longstanding tradition dating nearly 30 years to kick off its 2015 tournament season on Stockton. "We'll be there the first week in March and we're expecting teams to bring in plenty of limits, including fish into the teens," says tournament director Dan Palmer.
Traditionally, the circuit opener is held on the Illinois River at Spring Valley, Illinois. "The Illinois is still a world-class sauger fishery," Palmer says. "And we're going back there, too. I've long maintained we'll see the next Illinois state record sauger from this stretch. I've seen fish weighing up to 5 pounds 9 ounces in tournaments, very close to the record of 5-12½." He says the second two weeks of March are stellar on the Illinois, although, "Anytime the weather breaks in March is a great time to be on the river."
Long a "spring break" destination for sauger junkies, the Illinois kicks out fish on a variety of patterns. Jigging channel edges and other structural sweet spots with leadheads and minnows is popular, but other tactics work. "In 2014, we held an artificial-only Berkley Challenge event," Palmer says. "Tournament winners Scott Rhodes and Jeff Koester racked up a 10-fish limit weighing 26 pounds 4 ounces — trumping the total from the 2013 event, in which livebait was allowed, by nearly 8 pounds. Their tactics hinged on hand-lining crankbaits laced with walleye-formula Berkley PowerBait Attractant."
Palmer, who travels A-list fisheries each season working Cabela's MWC and National Walleye Tour events, ranks the Detroit River in April among his all-time hot spots. "The first two weeks of April are phenomenal," he says. "Waves of spawning walleyes flood the river from Lake Erie, creating one of the world's best chances at breaking the 10-pound barrier, with fish topping 15 pounds possible."
For perspective, at the MWC's annual Detroit River April tournament, it took two-day 10-fish totals of 87 pounds 3 ounces to win in 2014, and 86 pounds 2 ounces in 2013. In 2014, the big fish topped 13 pounds and big basket weighed over 50 — not bad for five walleyes in roughly eight hours of fishing.
"It's a jig fisherman's paradise," says Palmer. Dan Zwick, who won the 2014 MWC event with partner Tony Kobriger, concurs. "The Detroit River is incredible," he says. "These are the biggest walleyes I've ever caught jigging. There's nothing like getting bit by fish so huge they don't even budge when you set the hook." He and Kobriger concentrated on a rocky point in 14 to 17 feet of water, fishing 1/2-ounce jigs tipped with 3-inch Berkley Gulp! Alive! Ripple Shads.
Another mecca for trophy hunters is the mighty Columbia River. "It's always on my radar," says Stange. "The bite can already be happening by early February and into March, but primetime is late March until about April 15 or so, with the last week of March and the first week of April typically being prime."
'Eyes topping 20 are possible on the Columbia River.
The Columbia's reputation for producing giants in the 15- to 18-pound class is longstanding, and Washington's District 4 fishery biologist Paul Hoffarth says the river is currently on a roll. "Our walleye population has been growing for the past 15 years," he says. He credits top-shelf habitat, along with an abundance of juvenile shad and salmon, plus perch, peamouth, whitefish, and other forage, for fueling the production of super-size 'eyes.
On February 28, 2014, veteran river rat John Grubenhoff landed an enormous Columbia walleye that topped the 20-pound mark and demolished the Washington state record. He was fishing a 5¼-inch, silver-and-black J13 Jointed Rapala in the McNary Pool section of Lake Wallula, which is located between the McNary and Priest Rapids dams at the confluence of the Snake River. "It's a transition area where the free-flowing Columbia meets Wallula," he says.
Knowing the fish stage adjacent to spawning areas, he targeted a breakline and current edge a short cast from a rocky, windswept shoreline. His lure trailed 6 feet behind a 2-ounce bottom-walking sinker in 22 feet of water, as he trolled upstream along the break at .8 mph. Grubenhoff's monster weighed 20.32 pounds on a certified scale. The previous record was 19.3 pounds. Also a Columbia River fish, it was caught February 5, 2007 by Mike Hepper. Grubenhoff believes the Columbia holds even bigger walleyes.
Fall is another top time to tap the Columbia, Hoffarth says. "The night bite below McNary Dam is as good as it gets." Trolling deep-runners like the Luhr-Jensen Hot Lips Troller over humps in 18 to 24 feet is a prime program. For his part, Grubenhoff also recommends vertically jigging a 1/2-ounce bladebait such as a Heddon Sonar.
April ushers in world-class action on the Missouri River system. "The Missouri at Bismarck, North Dakota, is great for eater fish and chances at trophies, too," says veteran guide Jon Thelen, who crisscrosses the Midwest each season filming online and televised versions of Lindy Fishing Tackle's Fish Ed programming. "I don't think there's another bite that good in April."
Kavajecz agrees with Thelen's assessment of the Missouri, though from mid-April into May he sets his sights closer to Chamberlain, South Dakota. "Lake Francis Case can be fast and furious for fish from 16 to 20 inches, with 24s and 25s in the mix," he says. His pet presentation is a 3-inch Gulp! Minnow on a leadhead, fished on 5- to 10-foot feeding shelves.
Stange and Thelen sing the praises of North Dakota's Devils Lake. "You can't miss on a trip to pitch plugs for walleyes in late May on Devils Lake," says Stange. "Early to mid-May offers the best big-fish opportunities of the year on Devils," Thelen adds. "I focus on dead cattails, pitching jigs tipped with plastics or minnows, and snapping crankbaits."
From mid-summer into late October, Kavajecz hits northeast South Dakota's walleye wonderland, fishing lakes like Bitter and Waubay. "Glacial lakes in this area are phenomenal for numbers of 20- to 25-inch fish," he says. "Slow Death rigging is a killer there. Not so much on deeper breaks, but in 10 to 12 feet of water on the first drop off the weedline."
Another perennial producer virtually year-round, Lake Michigan gives up its big-water bounty as soon as the ice clears from hot spots like Sturgeon Bay. "I've been fishing with Guide Bret Alexander at the open mouths of port areas on Lake Michigan in Door County, particularly Sturgeon Bay, just after ice out in early May," says Stange. Palmer also notes the early bite on Sturgeon Bay: "Bass anglers targeting early smallmouths in tournaments haul in giant walleyes."
Veteran walleye pro Keith Kavajecz trolls and casts Green Bay all season, but favors May into June.
Kavajecz taps Green Bay all season, with late May into June his favorite time. "You can troll, but I like casting to 15 to 30 feet of water along the edges of reefs, shoreline points, and other breaklines with 3/8-ounce jigs tipped with 4-inch Gulp! Minnows in shades of chartreuse and pink," he says. "You can also cast glidebaits like Moonshine Tackle's Shiver Minnow in the same areas."
Thelen hits the Bay in July. "There's a great midsummer bite for fish of all sizes, including a pile in the 9- to 12-pound range," he says. "I pull Lindy crawler harnesses and crankbaits for suspended fish, from down in the bay up to the main lake."
Once August arrives, Thelen pulls up stakes for Minnesota's share of Lake of the Woods. "There's no better place for huge numbers of walleyes, with big-fish potential as well," he says. "You can anchor and jig or pull spinners, but for both eaters and trophies, plus bonus saugers, you can't beat trolling crankbaits like #3 Lindy River Rockers in the main basin in depths of 30 to 35 feet."
Palmer, also a veteran guide out of Wisconsin's iconic Hayward area, adds the Chippewa Flowage to his short list of must-fish waters, particularly in May. "The first two weeks after the early May opener are a riot," he says. Casting Berkley Flicker Shads in shallow areas around the mouths of rivers and spawning bays produces scads of 16- to 17-inch fish, with chances at bigger ones.
Palmer also likes the slice of legendary Lake Erie out of Huron, Ohio, in May. "Trolling Reef Runners to tap the postspawn run east for big, hungry females following smelt and shad is probably your best bet at a 10-plus anywhere in May," he explains. "At the MWC's May tournament there in 2013, big basket went 52-11 for five fish, which gives you an idea of what's out there."
Tournament pro and well traveled walleye angler Scott Glorvigen offers north-central Minnesota's Bowstring Lake as his pick for fast action from mid-May into June. "Fish Northland Fire-Ball jigs tipped with shiners in 4 to 6 feet along windswept weedlines," he says. "This isn't a trophy bite, but a wear-your-arm-out numbers game. Expect mostly eaters, with some fish up to 23 inches."
Thelen throws out his home waters of Minnesota's Mille Lacs Lake as a wild card for June. "The lake has had its troubles, but people who think we're down to the last spawning pair are way out of touch," he says. "The fish we're catching are healthier and fatter than ever, and June is the time to catch 14- to 29-inchers." With everything from shallow rocks and weedbeds to deep gravel and mud in play, anglers can play to their strong suits.
*Dan Johnson of Harris, Minnesota, is a frequent contributor to In-Fisherman publications and director of All Creation Outdoor Media. Guide contacts: Jeff Gustafson, gussyoutdoors.com; Dan Palmer, Grand Pines Guide Team, 715/462-4006; Jon Thelen, 612/720-3837.


The Volkswagen I.D. Vizzion concept went live a day before the Geneva auto show, following its cousins the I.D. Buzz and I.D. Crozz in a parade of new electric models that get us closer and closer to autonomous driving. The Vizzion promises Level 5 autonomy, which means it can operate solely on voice and gesture control, according to VW. It's a vision (get it?!) of what may be possible by the year 2030.
The Vizzion will have a complicated artificial intelligence system that learns about new situations on the fly. VW explains that a lane keeping system works with mathematical parameters and the visual information from the cameras. This would work in the same manner -- but in a way more complicated format. VW is using machine learning as we speak to train these systems, plugging in thousands of images of cars, trucks, bicycles and pedestrians so the camera can learn the difference between them. Eventually, it will be able to form its own conclusions AUTOMATICALLY. Yikes.
The Level 5 concept would conceivably use, according to VW, "inter-connected laser scanners, ultrasonic sensors, radar sensors for objects in the near-zone and radar sensors for long distances, front and rear cameras and side area view cameras." Future vehicles will also be connected to each other, and that data can be used as well.
The concept rides on VW's MEB architecture with two motors, two transmissions and electronics that link them, while a 111-kWh lithium-ion battery rides under the floor. A 101-hp motor sits in front with a 201-hp motor in back. VW says it will have a range of 413 miles on the European cycle.
The concept car is 203.3 inches long, 76.7 inches wide and 59.3 inches tall, but with a 122-inch roof. That will create more space for passengers, VW says. It looks a lot like a Tesla Model 3 to us in shape, but the VW is a good 19 inches longer.
There are also a couple rotary controls for you Luddites who might happen upon an I.D. Vizzion in the wild 12 years from now.
The Vizzion is clearly a very futuristic concept in that VW is aiming for the 2030 model year. As wild as most of this stuff is, think about where we were in 2008 -- very few autonomous features --with where we are today and where we'll be in 2028. Seems a bit less far-fetched, no?
We'll get a live look at the Geneva motor show this week.


Preceded in death by parents, Edward and Helen Costello; brothers, Ed and Bill Costello. Survived by sister, Rosemary Eastman (Jack); brothers, Jim Costello and Steve Costello (Mariellen); 25 nieces and nephews; numerous grandnieces and grandnephews.
The family will receive friends on Sunday, August 5th from 2pm to 4pm at Holy Cross Catholic Church, 480 Woolworth Ave., followed by VIGIL SERVICE at 4pm. MASS OF CHRISTIAN BURIAL: Monday, August 6th at 10:30am at Holy Cross Catholic Church. Interment: Calvary Cemetery.
Memorials are suggested to Holy Cross Catholic Church.


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Can a promising drug combination address one of the defining biological characteristics of ALS?
In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help prevent protein misfolding. This mechanism can become impaired when healthy motor neurons are compromised by disease processes. For years, Dr. Durham has been studying drugs that might enhance heat shock protein response in motor neurons. Recently, she has found a particular drug combination that can greatly increase the production of heat shock proteins in motor neurons.
This project sets the stage for researching a promising drug combination that may one day become an important therapy for people with ALS. Dr. Durham and collaborating researchers Dr. Josephine Nalbantoglu, Dr. Richard Robitaille, and Dr. Chantelle Sephton will seek to find the optimal combination of heat shock drugs together with a histone deacetylase drug and then examine the protective capabilities of the best combination in ALS mice. They will also investigate how the drugs work, which could lead to the development of potential biomarkers for human clinical trials in the future. The team will collaborate with multiple biotech and pharmaceutical companies that own the unique heat shock and histone deacetylase drugs. If this project is successful, the next step would be for drug companies to conduct toxicity testing and ultimately clinical trials with human volunteers.
What can we learn from mice that are able to walk almost normally despite significant loss of motor neuron function?
To study ALS in the lab, many researchers create mice with the disease. In recent experiments, they have discovered that the mice can walk almost normally despite significant loss of motor neuron function. One theory about why this is possible is that C-boutons, specialized synapses that provide chemical inputs to motor neurons, may increase in size and number to compensate for the loss of motor neuron function. In this project, Dr. Akay will examine how C-boutons change the chemical input to motor neuron cells to allow ALS mice with severe motor neuron loss to move quite well and whether that effect slows or accelerates ALS progression. He will also test drugs known to change C-bouton signalling to see if motor function can be preserved in ALS mice. If targeting C-bouton function can successfully slow disease progression in mice, it may prove to be a target worth pursuing in human studies in the future to find new ways to improve mobility and possibly slow disease progression.
Could touchscreen technology help to improve testing for the cognitive impairment that occurs in some cases of ALS?
A significant number of people with ALS also develop cognitive impairment that may include problems with language, thought processing and behavioural changes. A prominent protein called TDP-43 is associated with ALS and is also related to cognitive impairments in frontotemporal dementia. Over 95% of people with ALS have abnormal TDP-43 protein function. To date, researchers have not been able to effectively investigate cognitive impairment in ALS mice models with TDP-43 protein abnormalities as currently available tests for studying symptoms in ALS laboratory mice are not very sensitive and are prone to human error in measurement. Dr. Beraldo and colleagues are using a touchscreen system that resembles a box that uses iPads as the walls. By using food as a reward, they have trained mice to recognize images and touch the walls with their noses. In this project, the researchers will measure how well ALS mice complete the same tasks and hope to identify subtle levels of cognitive impairment compared to mice without ALS. The touchscreen system will allow the investigators to measure changes in cognitive impairment as motor neurons degenerate in ALS mice. If successful, this new technology could be used as a tool for measuring cognitive impairment in several other ALS mouse models or for screening drugs to find new treatments in the future.
Could targeting the activity of motor neurons in the spinal cord be a new way to diagnose and treat ALS?
Researchers have found that before the onset of ALS there is an increase in the activity of motor neurons in the spinal cord. One theory about why this happens is that there is a decrease in KCC2, a protein that's responsible for keeping hyperactivity in check by maintaining the right amount of chloride, a chemical that plays a role in activating neurons. Researchers have identified that people with the sporadic form of ALS have lower amounts of KCC2. Dr. De Koninck has developed two promising drugs that can increase KCC2 production. In this project, he will use ALS laboratory mice to test whether restoring KCC2 levels with these drugs – whether in upper motor neurons that originate in the brain, lower motor neurons that originate in the spinal cord, or both – can prevent neurodegeneration and motor deficits. Dr. De Koninck will also investigate whether measuring KCC2 in spinal fluid can be used as a biomarker to diagnose ALS before symptom onset. Altogether, this project has the potential to help us better understand, diagnose and treat ALS.
Can microscopic bubbles in our bodies be used to deliver ALS treatments through the bloodstream?
Gene mutations leading to disease often produce toxic proteins that, in the case of the inherited form of ALS, cause motor neurons to die. One of the most significant advancements in therapy over the past several years is the ability to use technology to target genetic diseases. Scientists have developed many treatments that can reduce the amount of these toxic proteins, but one of the major challenges has been delivering treatments to central nervous system. Our bodies have a specialized barrier called the blood-brain barrier that makes it very difficult to introduce drugs into the brain or nervous system.
Exosomes are microscopic bubbles that our body uses to transport substances from cell to cell. For years, researchers have tried to use exosomes in lab experiments to deliver therapies through the bloodstream, but the amount of treatment that can fit into each exosome has been a major limitation. Dr. Gibbings and colleagues have recently discovered a system to squeeze 1,000 times more treatment into each exosome. In this study, they will first test the ability of their system to deliver treatment to the brain after injection into the bloodstream, measure how many exosomes reach the destination and determine the cellular processes that allow the therapies to cross the blood-brain barrier. Second, they will use a well-studied ALS mouse model with mutations in a gene called SOD1 to see if exosomes loaded with a SOD1-targeted treatment can effectively reduce the levels of toxic, mutant SOD1 proteins. Throughout the project, they will continue working on modifying the exosomes to further enhance their ability to move treatments across the blood-brain barrier. If successful, this initial set of tests may provide the evidence needed to advance to testing exosome-delivered treatments in human clinical trials in the future.
Can adjusting the levels of a "guardian" protein protect a protein that becomes toxic in most cases of ALS?
Increased levels and clumping of the protein TDP-43 occur in more than 95% of ALS cases, making it an attractive target for understanding what causes the disease and finding new ways to treat it. In normal cells, a set of proteins called heat shock proteins may act as guardians to defend against TDP-43 toxicity. Dr. Prado and colleagues have demonstrated that the amount of a heat shock protein called STI1 is lower in ALS motor neurons compared to healthy motor neurons and that these lower levels directly affect the toxicity of abnormal TDP-43. In this project, they will study mice with abnormal TDP-43 and determine whether increasing or decreasing STI1 levels can preserve motor neuron health. Understanding this mechanism of action may shed light on future potential avenues for treatment. This project could also provide the first evidence that STI1 itself might be a valuable target to test in human clinical trials.
Why are eye muscles often more resistant to ALS, and what can we learn about this that could help to preserve the function of other muscles?
Many researchers believe that one of the earliest events in ALS is the detachment of motor neurons from muscles at a site called the neuromuscular junction (NMJ) and have discovered that some NMJs are more vulnerable than others. In both humans and ALS laboratory mice, the eye muscles preserve the connections longer, which is why many assistive technology devices for ALS use eye movements for control. Previous work by Dr. Robitaille has revealed that specialized supporting cells called Perisynaptic Schwann Cells (PSCs) are critical for maintaining the NMJ connection and that PSC function is impaired in ALS mice. In this project, Dr. Robitaille will examine PSC function in ALS mice before and after they develop disease symptoms and compare the results to normal mice. He will also compare PSC function in eye NMJs with PSC function in leg NMJs, which are known to show early impairment. Also, Dr. Robitaille will analyze the entire set of proteins in both the resistant and susceptible NMJs and compare the results to look for specific markers that might explain the preserved function in eye muscles. If successful, this project could discover new targets for treatments that might preserve NMJs all over the body by enhancing PSC function.
Could the change in communication processes between motor neurons and the immune cells of the nervous system after an ALS diagnosis help to identify new treatment targets?
Increasing evidence shows that the communication between motor neuron cells and other cell types plays a role in disease progression. Microglia, the immune cells of the nervous system, play a role in protecting motor neurons in healthy people but during disease processes like with ALS, they can become inflammatory and contribute to motor neuron death. These communication processes are challenging to study in human volunteers. In this project, Dr. Stifani will grow human microglia and motor neurons in the laboratory from the blood cells of people with ALS and examine how the cells communicate. He will compare the communication processes with ALS cells with those from cells that do not have ALS mutations. Overall, this project may provide a new understanding of how microglia play a role in human ALS and reveal new treatment targets. Dr. Stifani is already pursuing a similar study with another glial cell type called astrocytes as part of a research project led by Dr. Guy Rouleau that was funded by ALS Canada and Brain Canada in 2016, making this latest grant an important addition to an ongoing project expected to have a significant impact on ALS research.
Can image-guided focused ultrasound technology be used safely in people living with ALS as a means of delivering future treatment?
Delivering promising treatments to the nervous system is challenging because our bodies have a specialized barrier called the blood-brain barrier that makes it difficult to introduce drugs into the brain or nervous system. Researchers at the Sunnybrook Health Sciences Centre and the University of Toronto have developed a new technology to deliver treatments through the blood-brain barrier using image-guided focused ultrasound that can open small spaces in the barrier to let the treatments cross into the brain. They have demonstrated the safety of this technique in people with essential tremor and are currently studying the approach in patients with Alzheimer's disease in a clinical trial. In this project, Dr. Zinman and colleagues will test the safety of image-guided focused ultrasound in eight people living with ALS. If successful, the team hopes to use the technology to deliver promising treatments that target upper motor neurons to enhance treatments that are currently directed at lower motor neurons and are already being tested in clinical trials.
Could whole genome sequencing reveal new areas of genetic mutations that make some people more likely to develop ALS?
DNA is a complex molecule containing a sequence of genes that act as the master code for building and maintaining living things. Changes in the sequence are not necessarily harmful, but a small percentage of gene mutations can result in diseases like cystic fibrosis, Huntington's disease and ALS. Using a technology called exome sequencing that uses human blood samples to examine specific sections of DNA, scientists have discovered several genes and genetic mutations related to ALS. Newer technology, called whole genome sequencing, has provided scientists with the ability to examine the complete set of DNA, known as the genome, instead of just the sections that carry protein instructions. ALS Canada is leading Canada's participation in Project MinE, a multinational initiative to create an open-access database of the full DNA profiles of people living with ALS that researchers around the world can use to look for insights. In this project, Jay Ross, a PhD student in Dr. Guy Rouleau's lab at McGill University, will analyze whole genome sequencing data from the Project MinE database for a group of French Canadians living with ALS to look for new areas of genetic mutations that make some people more susceptible to developing the disease. Additionally, he will investigate how the mutations influence disease processes at the cellular level, which may lead to the identification of new targets for potential drug treatments.
How might misfolded proteins that occur in ALS cause cells to die?
Proteins are the substances responsible for almost all cellular functions and are often called the workhorses of the cell. To perform their tasks in the body correctly, proteins must first fold into the right 3D shape. Misfolded proteins, those that do not adopt the correct shape, can be harmful to cells. The body uses a variety of "quality control" mechanisms to help misfolded proteins refold into the right shape or destroy them before they can pose a threat. In some cases, however, these quality control mechanisms fail to prevent misfolded proteins from accumulating, which can cause cells to die. Protein-misfolding processes have been associated with a variety of different neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and ALS.
Sonja Di Gregorio, a PhD student in Dr. Martin Duennwald's lab at Western University, is studying how the misfolding of three ALS-associated proteins —TDP-43, FUS/TLS and RGNEF — affects the quality control mechanisms of cells, and why protective processes fail in ALS. Using yeast cells that have been altered with genetic mutations linked to ALS, she will investigate how accumulated misfolded proteins lead to cell death. She will also study the biological properties of RGNEF, a protein only recently linked to ALS, to identify how mutations in this protein may lead to the development of ALS. For this part of the project, Di Gregorio will use yeast models, animal cell models and post-mortem human tissue samples. Findings from this project may provide a new target for the development of ALS treatments.
Will probiotics that improve ALS symptoms in worms also work in mice?
Trillions of microbes including bacteria, fungi and viruses live on and in the human body in a community called the microbiota. Many of the microbes are friendly and contribute to normal, healthy functions – but others are associated with diseases. For example, changes in the collection of microbes in the respiratory tract have been linked to asthma. Recent scientific evidence has found a link between changes in the microbiota and neurodegenerative diseases like Parkinson's disease.
To investigate whether the microbiota plays a role in ALS, Audrey Labarre, a PhD student in Dr. Alex Parker's lab at the Université de Montréal, has been studying ALS worms. Worms are useful models for studying the biology of ALS because they have a short life span, allowing scientists to see quickly how new experimental treatments affect mobility and disease progression. When scientists alter worms by creating a genetic mutation that causes ALS, the worms develop motor neuron degeneration and paralysis. Labarre's work to date has involved treating ALS worms with probiotics – friendly, live bacteria that are known to be beneficial to the digestive tract. She has found that certain strains of probiotics have resulted in reduced death of motor neurons as well as increased mobility in the worms. In this project, Labarre will treat ALS mice with the same probiotic strains to see if she can find similar results. This research may confirm a link between the microbiota and ALS, paving the way for future therapies that could target the bacterial population in the digestive systems of people living with ALS.


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Leadership Essay
Submitted By adams1992
"The concept of collaborative leadership challenges conventional thinking and popular leadership theories by elevating the importance of interpersonal dynamics between people engaged in collective action in change-oriented environments," (Cox, 2009, p. 1). In today's organizations leadership is no longer viewed as a top-down practice. While the dominant models of leadership portray a style of hierarchical systems of power, the collaborative approach inspires a shared vision amongst all members. "The Leadership Challenge," discussed in class, will be used throughout this paper to connect the collaborative leadership style back to the five practices of exemplary leadership outlined in chapter 1: "model the way, inspire a shared vision, challenge the process, enable others to act, and encourage the heart," (Kouzes & Posner, 2012, p. 15). In most hierarchically organized companies, employees keep their opinions to themselves, do their job, and offer no feedback, (Standfield, 2003). It is imperative that organizations adjust their internal leadership styles to the changing political, economic, legal, and social factors to allow for all employees to voice their opinions on how the organization can operate more effectively. When participation is practiced with involvement of employees at all levels, mutual respect, and high creativity being rewarded, a new collaborative style is realized (Stanfield, 2003). Where power and control games ruled, organizations are now in favour of a more creative process and partnership. The old style of leadership stressed that decisions ought to be made by top executives and management. But utilizing a collaborative leadership system, organizations now stress representative or direct participation in making decisions. This approach allows for employees at all levels to offer insight on the effectiveness of the company.
Kouzes, J. M., & Posner, B. Z. (2012). The leadership challenge (5th ed.). San Francisco, CA: Jossey-Bass.
Cox, J. D. (2009). Leadership without a leader: An exploratory study of collaborative leadership. (Order No. 3359818, Capella University). ProQuest Dissertations and Theses, 260-n/a. Retrieved from http://search.proquest.com/docview/305159331?accountid=9744. (305159331).
-	Collaboration requires a mindset that reaches beyond a systems-based thinking; rather, it requires people to understand and reflect the complex and process nature of human interaction. This mindset challenges the dominant discourse in a radical way, offering in its place assumptions of seeing individual and organization simultaneously as part of the same social construct.
-	Transformational leadership theory. "Transformational leaders inspire followers to achieve extraordinary outcomes by providing both meaning and understanding" (Boerner et al., 2007, p. 16). Humphreys (2001) said this inspiration is accomplished based on a value system where the leader demonstrates charisma, motivates followers through inspiration, stimulates the intellectual capabilities of followers, and is attuned to the individuality of 31followers. Focus is placed on cultivating dedication on the part of followers, not because of any self-interest exchange but rather on the belief that what is being done is for the good of the whole. Under this leadership approach, "leaders and followers share mutual interests and a sense of shared fates and interdependence" (Bass & Avolio, 1993, p. 116). Transformational leaders are considered to be visionary change agents and have the ability to use instability and uncertainty to institute change in an organization. Transformational leaders guide people as they develop shared meanings about organizational topics such as values, issues, and operations (Kent, Crotts, & Azziz, 2001). To accomplish this concept of sharing, Yukl (2002) said that leaders "Articulate a clear and appealing vision. Explain how the vision can be attained. Act confidently and
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use Nette;

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redpajama_set_name: RedPajamaGithub


Rawson's Retreat is a classic federation style home situated in one of the best locations in leafy East Tamworth. Perfect for one, two, or three couples, or families looking for a holiday escape with style. Also suitable for business executives looking for comfort, privacy and facilities for a short or extended stay.
Rawson's Retreat also has boardroom facilities with seating for 18. Separate access to the boardroom from the front of the building, ensures privacy for both those staying at the cottage as well as visitors arriving for meetings. Catering for meetings and conferences is also available on request.


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If the start-up isn't a tech company, it may have a hard time finding investors. In fact, unless a consumer products company has surpassed $10 million in sales, it doesn't even begin to attract private equity investors. As a result, these food, agriculture, retail and other consumer oriented businesses have a difficult time breaking into the market.
However, the Securities and Exchange Commission has been leery about fully endorsing crowdfunding. Crowdfunding was a part of the Jump-Start Our Business Start-Ups Act which President Barack Obama signed last April. Without the help of crowdfunding, many smaller entrepreneurs are forced to max out their credit cards in hopes of getting their company off the ground.
A company called CircleUp was launched, aiming to connect up-and-coming consumer products companies with investors. CircleUp takes applications from companies with $1 million to $10 million in revenue. "Companies whose applications are accepted make their pitches to investors behind a firewall on the CircleUp Web site, offering equity stakes in return for capital" (Cortese, Amy." The Crowdfunding Crowd is Anxious." New York Times January 2013). CircleUp does take a small cut of the money.
Despite certain reservations that seem to be arising, it is important to keep in mind that consumer goods businesses make-up a large part of America's businesses. It is worth creating new methods and structures like crowdfunding to ensure these start-ups get the funding they need to keep America's economy going strong.
CircleUp gives entrepreneurs a way to raise money while providing investors with opportunities they may not otherwise hear about. In seven weeks, one of the seven companies CircleUp has assisted called Little Duck Organics raised nearly $900,000 from about a dozen investors on the site.


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Q: IIS 7.5 Reverse Proxy Implementation I am curious to understand how IIS 7.5 Reverse Proxy is implemented in Rewrite Module (v2).
I am planning to setup a website that will handle proxing between requests coming from users (internet) and my HTTP services that are deployed on the same server. I have setup a website within IIS and configured the reverse proxy logic. I've then setup another website on the same server and deployed all my WCF REST services there. I am planning to implement IIS offloading, common tasks (such as authentication, etc) on the reverse proxy website before the request gets to the actual services (like WCF routing service for SOAP). Configuration is working perfectly fine.
However I am trying to understand the implications of this setup. When IIS does reverse proxing, does it create a new HTTP request (and a new TCP port) between those two websites? And even if both sites are on the same server? Should I expect number of TCP connections opened on this server to get doubled when reverse proxy is used?
Furthermore, has anyone experienced any performance/resource issues with a similar setup?
Cheers,
OS


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Cinema of the World A comprehensive library of Arthouse..Cult,Classic,Experimental and rare movies from all over the world.
Jean Renoir – French Cancan (1954)
in 1951-1960, Comedy, France, Jean Renoir July 30, 2018	0 1,420 Views
Henri Danglard, proprietor of the fashionable (but bankrupt) cafe 'Le Paravent Chinois' featuring his mistress, belly dancer Lola, goes slumming in Montmarte (circa 1890) where the then-old-fashioned cancan is still danced. There, he conceives the idea of reviving the cancan as the feature of a new, more popular establishment…and meets Nini, a laundress and natural dancer, whom he hopes to star in his new show. But a tangled maze of jealousies intervenes…
French Cancan
by Andrew Sarris
French Cancan, produced at the Francoeur Studios in Saint–Maurice, had its Paris premiere in May 1955 and was mostly successful as a fun musical with both the critics and the public. In later decades, the critics around the world hailed the magnitude of Jean Renoir's achievement in employing and exalting the cancan as a metaphor for all artistic endeavors. Ultimately, French Cancan has turned out to be the happiest and most exuberant ripple in Renoir's career as a river of personal expression.
In the Paris of the 1880s, the impresario Danglard (Jean Gabin) decides to revive an old working-class dance, which he christens "French cancan" to make it sound vaguely "foreign" and "naughty," and to entice British and American tourists. He has troubles with his backers and their mistresses, culminating in a catastrophic catfight between an Egyptian belly dancer named La Belle Abbesse (Maria Félix) and a poor working girl-turned-cancan star Nini (Françoise Arnoul). Eventually, all the problems are solved, and French cancan is triumphantly launched at the newly unveiled Moulin Rouge.
Renoir wrote the screenplay, based on an idea of André-Paul Antoine, and there is a pervasive feeling of improvisation in most of the scenes. Renoir once remarked that he had spoken the screenplay more than he had written it. The film is one of the screen's most extraordinary beautiful displays of late cinematic maturity. Renoir's impressive personal testament on the collaborative arts is couched in a way to reflect the softening contours of his sensuous world, and the result is aesthetically parallel to such latter-day works as John Ford's The Searchers (1956) and Luis Buñuel's The Discreet Charm of the Bourgeoisie (1972). French Cancan is an artist's tribute to art, with Gabin's dedicated impresario serving as an alter ego for Renoir. Against the pastel-colored backgrounds of Auguste Renoir's Paris, all the characters in the movie attempt to find some modus vivendi between art and life, but only the impresario knows that ultimately his creation (the cancan and its dancers) will engulf the audience, just as art engulfs life and then becomes part of living. Renoir hurls his Cancan at the viewer, tempting us with the consuming spectacle, which is not only a more stirring conception than John Huston's art-gallery staging of the dance in Moulin Rouge (1952), but one more inherently kinetic and ineffably voluptuous.
Gabin the actor was a kind of alter ego for Renoir as well. "I like French Cancan," Renoir wrote in My Life and My Films, "because it gave me another chance to work with Jean Gabin. It was a return to the past, to my companion in The Lower Depths (1936), Grand Illusion (1937), and La Bête humaine (1938), and I am grateful to the cinema for having given me this comradeship. I love Gabin and he loves me. But we do not know one another. He knows nothing of my private life and I know nothing of his. Our relationship is entirely professional, but I have a feeling that his tastes are pretty much the same as mine."
As François Truffaut once noted, Renoir repeatedly avoided the banality of a romantic triangle by having three lovers competing for the hand of the beloved. In French Cancan, Françoise Arnoul's Nini is involved with Jean Gabin's Danglard, Giani Esposito's Prince Alexandre, and Franco Pastorino's Paulo, the baker and Nini's first love. The three suitors represent three perplexing choices. Renoir's European sensibility does not allow him to indulge in John Huston's puritanical pessimism in Moulin Rouge about artists and models facing nothing but old age and death. Life and art are more complicated than that in French Cancan. "Everyone has his reasons," complains Jean Renoir's Octave in The Rules of the Game (1939), and everyone has his reasons in French Cancan. Danglard lives from one show to the next, and from one woman to the next. Nini finds that she cannot find fame and fidelity at the same time and in the same place and in the same person. Yet though the show must go on, life must go on, too, and the process of choice is not without pain and cruelty.
Although Renoir was a man of the left for most of his adult life, he never sacrificed ambiguity to ideology. He can caricature high society and the aristocracy, but with remarkably little malice. By the same token, he does not sentimentalize the poor. He remains a compassionate observer of the sheer strangeness and variety of existence. It would be an oversimplification to describe him as a humanist, and it would be a mistake to confuse his pantheistic fatalism with aimlessness and artlessness. Only repeated viewings of Renoir's films uncover the inexorable logic and lucidity of his style. Still, of all his films, French Cancan is the one that bursts out again and again with lyrical explosions of color, vitality, and sensuality. There is unmistakably more to Renoir than meets the eye, but what an eye he has.
Andrew Sarris is a film critic for The New York Observer, and a professor of film at the School of the Arts at Columbia University. His most recent book is You Ain't Heard Nothin' Yet: The American Talking Film: History& Memory, 1929–1949.
http://nitroflare.com/view/D1FD3F81D331C39/French.Cancan.1954.DVDRip.XViD.AC3.TINSeL.avi
http://www.nitroflare.com/view/D06D4625C59CF6E/French.Cancan.1954.DVDRip.XViD.AC3.TINSeL.idx
http://www.nitroflare.com/view/B69B8332A0DC8BF/French.Cancan.1954.DVDRip.XViD.AC3.TINSeL.rar
Language(s):French
Subtitles:English (idx / sub)
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Tian Ruining is een Chinees schaatsster.
Ze begon op tienjarig leeftijd met de schaatssport.

In 2018 nam ze deel aan de Olympische Winterspelen 2018 waar ze onder andere uitkwam op 1000 en 1500 meter. Hier behaalde ze respectievelijk de 21ste (1:16,69) en een 23ste (met 2:00,29) plaats.

Records

Persoonlijke records

Resultaten

(#, #, #, #) = afstandspositie op sprinttoernooi (500m, 1000m, 500m, 1000m) of op juniorentoernooi (500m, 1500m, 1000m, 3000m).

Chinees schaatser
Chinees olympisch deelnemer

redpajama_set_name: RedPajamaWikipedia


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Chinese club Guangzhou Evergrande announced the loan of their former player and Brazilian international Paulinho (29).
Paulinho spent one year Barcelona where he won domestic double while featuring in 49 matches in Blaugrana shirt and marking 9 goals and 3 assists.
Financial details of the loan/transfer to follow.
Won't pretend I knew much about him when we decided to pay his release clause, but I've grown fond of him. Such a likable character. Managed to surprise a few, won the double, was extremely useful, earned his place in Brazil's 11 - now decided to go back to China.
Guess we'll have hard time finding his replacement.
No rest this summer too. Would be playing the game for 2 years without holidays now. Will be tough. But he seems determined and really loves Chinese league.
They are offering 50m for him a year on and he is not a nailed starter.
He did well enough and better than a lot expected but 50m for Paulinho at 30? Cant turn that down.
We wanted to spend 100m on Griezmann which we didn't end up doing. Will receive 50m for Paulinho. Hopefully 30m for Gomes from either Arsenal or Tottenham.
Can we a little more ambitious and make a proper power move that can help take us over the line in the CL?
^We have got plenty of money. Who do you think we should spend what we have got on?
I believe there are two positions that we need to reinforce and they are CM and LW. The issue is that there are not any good CMs and LWs that worth spending on. Maybe Eriksen?
There is also Dybala, but he does not fit our team nor M Savic.
Hopefully 30m for Gomes from either Arsenal or Tottenham.
Are they actually after him? Seems completely unfit for purpose. He belongs somewhere like Monaco, Seville or Napoli.
We lost one of the few remaining players with some balls and muscle. Don't know what's the plan now but we better get some steel in.
How are we going to get 50m if it is a loan?


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Albert Sterling
December 27th, 1921 to February 8th, 2006
Albert J. Sterling, Sr., 84, died Wednesday, February 8, 2006 in his home after a battle with cancer. He was born December 27, 1921 in St. Clair. He married Margaret Eckert on November 8, 1941 in St. Clair. Albert attended St. Mary's Elementary in St. Clair. He was the designer and fabricator for the first patented U.L. approved gas fireplace for the mobile home industry. Albert was the owner of Sterling Fireplace Shop in Marysville. He was an avid hunter and fisherman. He is survived by his wife Margaret E. Sterling of Marysville; son, A. James (Lu) Sterling, Jr. Of Algonac; daughters, Martha (Dick) Sopha of St. Clair and Jan Sterling of Marysville; son, Bob (Cheryl) Sterling of Chesterfield Twp; daughter, Margaret A. Sterling of Marysville; son John Sterling of Ft. Gratiot; grandchildren, Jim (Emily) Sopha, Julia (Timm) Balunis, David Sopha, Jennifer (Mark) McDonald , Amanda Shurkey, John, Emily and Abby Sterling; great-grandchildren, Nathan, Josiah, Jacob, Jonas and Alexzander; brother, Lambert Sterling of Florida. He is preceded in death by his parents, Harvey and Emily; brothers, Harvey and Bud; sisters, Mary and Betty; granddaughter, Kimberly and sister-in-law, Peggy. Funeral Mass will be 10 a.m. Monday in St. Christopher Church. The Rev. Arthur R. Baranowski will officiate. Burial will be in Riverlawn Cemetery. Visiting hour are 2-4 & 6-8 p.m. Sunday at Karrer-Simpson Funeral Home and from 9 a.m. until the service time Monday at church. A rosary will be recited 3:30 p.m. Sunday.