text:
hits 1 - 10 | 124 hits
BREAST-CANCER (3)
Protein Binding (3)
*Evolution, Molecular (2)
Alleles (2)
DNA-Binding Proteins/genetics/*metabolism (2)
DOWN-REGULATION (2)
Embryonic Stem Cells (2)
GENE-EXPRESSION (2)
IN-VITRO (2)
Oxidation-Reduction (2)
American Chemical Society (4)
International Union of Crystallography (IUCr) (3)
Cold Spring Harbor Laboratory Press (2)
BMJ Publishing (1)
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Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models (2018)
Ai, J., Chen, Y., Peng, X., Ji, Y., Xi, Y., Shen, Y., Yang, X., Su, Y., Sun, Y., Gao, Y., Ma, Y., Xiong, B., Shen, J., Ding, J., Geng, M.
The American Association for Cancer Research (AACR)
In: Molecular Cancer Therapeutics
Description: Because the receptor tyrosine kinase c-Met plays a critical role in tumor growth, metastasis, tumor angiogenesis, and drug resistance, the c-Met axis represents an attractive therapeutic target. Herein, we report the first preclinical characterization of SCC244, a novel, potent, and highly selective inhibitor of c-Met kinase. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date. Moreover, this inhibitor profoundly and specifically inhibits c-Met signal transduction and thereby suppresses the c-Met–dependent neoplastic phenotype of tumor and endothelial cells. In xenografts of human tumor cell lines or non–small cell lung cancer and hepatocellular carcinoma patient-derived tumor tissue driven by MET aberration, SCC244 administration exhibits robust antitumor activity at the well-tolerated doses. In addition, the in vivo antitumor activity of SCC244 involves the inhibition of c-Met downstream signaling via a mechanism of combined antiproliferation and antiangiogenic effects. The results of the current study provide a strong foundation for the clinical investigation of SCC244 in patients with tumors harboring c-Met pathway alterations. Mol Cancer Ther; 17(4); 751–62. ©2017 AACR .
Published by The American Association for Cancer Research (AACR)
Cell Death Mechanisms and the Immune System (1991)
Golstein, Pierre ; Ojcius, David M. ; Young, J. Ding-E
Oxford, UK : Blackwell Publishing Ltd
Immunological reviews 121 (1991), S. 0
Source: Blackwell Publishing Journal Backfiles 1879-2005
URL: http://dx.doi.org/10.1111/j.1600-065X.1991.tb00822.x
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis (2013)
K. Xu ; M. Zhang ; Q. Zhao ; [et al.] F. Yu ; H. Guo ; C. Wang ; F. He ; J. Ding ; P. Zhang
In: Nature. 497(7448): 268-71. doi: 10.1038/nature12046.
Description: ATP-binding cassette (ABC) transporters, composed of importers and exporters, form one of the biggest protein superfamilies that transport a variety of substrates across the membrane, powered by ATP hydrolysis. Most ABC transporters are composed of two transmembrane domains and two cytoplasmic nucleotide-binding domains. Also, importers from prokaryotes usually have extra solute-binding proteins in the periplasm that are responsible for the binding of substrates. Structures of importers have been reported that suggested a two-state model for the transport mechanism. Energy-coupling factor (ECF) transporters belong to a new class of ATP-binding cassette importers. Each ECF transporter comprises an energy-coupling module consisting of a transmembrane T protein (EcfT), two nucleotide-binding proteins (EcfA and EcfA'), and another transmembrane substrate-specific binding S protein (EcfS). Despite the similarities with ABC transporters, ECF transporters have different organizational and functional properties. The lack of solute-binding proteins in ECF transporters differentiates them clearly from the canonical ABC importers. Previously reported structures of the EcfS proteins RibU and ThiT clearly demonstrated the binding site of substrate riboflavin and thiamine, respectively. However, the organization of the four different components and the transport mechanism of ECF transporters remain unknown. Here we present the structure of an intact folate ECF transporter from Lactobacillus brevis at a resolution of 3 A. This structure was captured in an inward-facing, nucleotide-free conformation with no bound substrate. The folate-binding protein FolT is nearly parallel to the membrane and is bound almost entirely by EcfT, which adopts an L shape and connects to EcfA and EcfA' through two coupling helices. Two conserved XRX motifs from the coupling helices of EcfT have a vital role in energy coupling by docking into EcfA-EcfA'. We propose a transport model that involves a substantial conformational change of FolT.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Ke -- Zhang, Minhua -- Zhao, Qin -- Yu, Fang -- Guo, Hui -- Wang, Chengyuan -- He, Fangyuan -- Ding, Jianping -- Zhang, Peng -- England -- Nature. 2013 May 9;497(7448):268-71. doi: 10.1038/nature12046. Epub 2013 Apr 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Key Laboratory of Plant Molecular Genetics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23584589" target="_blank"〉PubMed〈/a〉
Keywords: ATP-Binding Cassette Transporters/chemistry ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Bacterial Proteins/*chemistry/metabolism ; Conserved Sequence ; Crystallography, X-Ray ; Folic Acid Transporters/*chemistry/metabolism ; Lactobacillus brevis/*chemistry ; Models, Molecular ; Protein Conformation ; Protein Subunits/chemistry/metabolism ; Proteolipids/metabolism
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity (2014)
R. Noubade ; K. Wong ; N. Ota ; [et al.] S. Rutz ; C. Eidenschenk ; P. A. Valdez ; J. Ding ; I. Peng ; A. Sebrell ; P. Caplazi ; J. DeVoss ; R. H. Soriano ; T. Sai ; R. Lu ; Z. Modrusan ; J. Hackney ; ... and further 1
Description: Reactive oxygen species (ROS) produced by phagocytes are essential for host defence against bacterial and fungal infections. Individuals with defective ROS production machinery develop chronic granulomatous disease. Conversely, excessive ROS can cause collateral tissue damage during inflammatory processes and therefore needs to be tightly regulated. Here we describe a protein, we termed negative regulator of ROS (NRROS), which limits ROS generation by phagocytes during inflammatory responses. NRROS expression in phagocytes can be repressed by inflammatory signals. NRROS-deficient phagocytes produce increased ROS upon inflammatory challenges, and mice lacking NRROS in their phagocytes show enhanced bactericidal activity against Escherichia coli and Listeria monocytogenes. Conversely, these mice develop severe experimental autoimmune encephalomyelitis owing to oxidative tissue damage in the central nervous system. Mechanistically, NRROS is localized to the endoplasmic reticulum, where it directly interacts with nascent NOX2 (also known as gp91(phox) and encoded by Cybb) monomer, one of the membrane-bound subunits of the NADPH oxidase complex, and facilitates the degradation of NOX2 through the endoplasmic-reticulum-associated degradation pathway. Thus, NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noubade, Rajkumar -- Wong, Kit -- Ota, Naruhisa -- Rutz, Sascha -- Eidenschenk, Celine -- Valdez, Patricia A -- Ding, Jiabing -- Peng, Ivan -- Sebrell, Andrew -- Caplazi, Patrick -- DeVoss, Jason -- Soriano, Robert H -- Sai, Tao -- Lu, Rongze -- Modrusan, Zora -- Hackney, Jason -- Ouyang, Wenjun -- England -- Nature. 2014 May 8;509(7499):235-9. doi: 10.1038/nature13152. Epub 2014 Apr 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA [2] Flexus Biosciences, 75 Shoreway Road, Suite D, San Carlos, California 94070, USA (R.N.); American Society for Biochemistry and Molecular Biology, 11200 Rockville Pike, Suite 302, Rockville, Maryland 20852, USA (P.A.V.). ; Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. ; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. ; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. ; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. ; Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24739962" target="_blank"〉PubMed〈/a〉
Keywords: Animals ; Autoimmunity/genetics ; Bone Marrow Cells/cytology ; Central Nervous System/metabolism/pathology ; Encephalomyelitis, Autoimmune, Experimental/*immunology/*metabolism/pathology ; Endoplasmic Reticulum/enzymology/metabolism ; Escherichia coli/*immunology ; Female ; Inflammation/immunology/metabolism/pathology ; Listeria monocytogenes/*immunology ; Macrophages/cytology/enzymology/immunology/metabolism ; Male ; Mice ; NADPH Oxidase/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Phagocytes/cytology/immunology/metabolism ; Proteins/genetics/*metabolism ; Reactive Oxygen Species/*antagonists & inhibitors/metabolism
The long-term maintenance of a resistance polymorphism through diffuse interactions (2014)
T. L. Karasov ; J. M. Kniskern ; L. Gao ; [et al.] B. J. DeYoung ; J. Ding ; U. Dubiella ; R. O. Lastra ; S. Nallu ; F. Roux ; R. W. Innes ; L. G. Barrett ; R. R. Hudson ; J. Bergelson
Description: Plant resistance (R) genes are a crucial component in plant defence against pathogens. Although R genes often fail to provide durable resistance in an agricultural context, they frequently persist as long-lived balanced polymorphisms in nature. Standard theory explains the maintenance of such polymorphisms through a balance of the costs and benefits of resistance and virulence in a tightly coevolving host-pathogen pair. However, many plant-pathogen interactions lack such specificity. Whether, and how, balanced polymorphisms are maintained in diffusely interacting species is unknown. Here we identify a naturally interacting R gene and effector pair in Arabidopsis thaliana and its facultative plant pathogen, Pseudomonas syringae. The protein encoded by the R gene RPS5 recognizes an AvrPphB homologue (AvrPphB2) and exhibits a balanced polymorphism that has been maintained for over 2 million years (ref. 3). Consistent with the presence of an ancient balanced polymorphism, the R gene confers a benefit when plants are infected with P. syringae carrying avrPphB2 but also incurs a large cost in the absence of infection. RPS5 alleles are maintained at intermediate frequencies in populations globally, suggesting ubiquitous selection for resistance. However, the presence of P. syringae carrying avrPphB is probably insufficient to explain the RPS5 polymorphism. First, avrPphB homologues occur at very low frequencies in P. syringae populations on A. thaliana. Second, AvrPphB only rarely confers a virulence benefit to P. syringae on A. thaliana. Instead, we find evidence that selection for RPS5 involves multiple non-homologous effectors and multiple pathogen species. These results and an associated model suggest that the R gene polymorphism in A. thaliana may not be maintained through a tightly coupled interaction involving a single coevolved R gene and effector pair. More likely, the stable polymorphism is maintained through complex and diffuse community-wide interactions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696508/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696508/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karasov, Talia L -- Kniskern, Joel M -- Gao, Liping -- DeYoung, Brody J -- Ding, Jing -- Dubiella, Ullrich -- Lastra, Ruben O -- Nallu, Sumitha -- Roux, Fabrice -- Innes, Roger W -- Barrett, Luke G -- Hudson, Richard R -- Bergelson, Joy -- R01 GM046451/GM/NIGMS NIH HHS/ -- R01 GM057994/GM/NIGMS NIH HHS/ -- R01 GM062504/GM/NIGMS NIH HHS/ -- R01 GM083068/GM/NIGMS NIH HHS/ -- R01GM046451/GM/NIGMS NIH HHS/ -- T32 GM007197/GM/NIGMS NIH HHS/ -- England -- Nature. 2014 Aug 28;512(7515):436-40. doi: 10.1038/nature13439. Epub 2014 Jul 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA [2] Committee on Genetics Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA [3]. ; 1] Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA [2] Monsanto Vegetable Seeds, 37437 State Highway 16, Woodland, California 95695, USA (J.M.K.); State Key Laboratory of Plant Genetics and Germplasm Enhancement and College of Horticulture, Nanjing Agricultural University, Nanjing, China (J.D.); CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia (L.G.B.). [3]. ; Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA. ; Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. ; 1] Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA [2] Monsanto Vegetable Seeds, 37437 State Highway 16, Woodland, California 95695, USA (J.M.K.); State Key Laboratory of Plant Genetics and Germplasm Enhancement and College of Horticulture, Nanjing Agricultural University, Nanjing, China (J.D.); CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia (L.G.B.). ; 1] INRA, Laboratoire des Interactions Plantes-Microorganismes (LIPM), UMR441, F-31326 Castanet-Tolosan, France [2] CNRS, Laboratoire des Interactions Plantes-Microorganismes (LIPM), UMR2594, F-31326 Castanet-Tolosan, France [3] Laboratoire Genetique et Evolution des Populations Vegetales, UMR CNRS 8198, Universite des Sciences et Technologies de Lille - Lille 1, F-59655 Villeneuve d'Ascq Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25043057" target="_blank"〉PubMed〈/a〉
Keywords: Alleles ; Arabidopsis/*genetics/*microbiology ; Arabidopsis Proteins/*genetics/metabolism ; Bacterial Proteins/genetics/metabolism ; *Evolution, Molecular ; Genes, Plant/genetics ; Host-Pathogen Interactions/*genetics ; Models, Genetic ; Plant Immunity/genetics ; *Polymorphism, Genetic ; Pseudomonas syringae/*genetics/pathogenicity ; Selection, Genetic/*genetics ; Virulence/genetics
Lagging-strand replication shapes the mutational landscape of the genome (2015)
M. A. Reijns ; H. Kemp ; J. Ding ; [et al.] S. M. de Proce ; A. P. Jackson ; M. S. Taylor
Description: The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a replicative origin for such mutations. Using a novel method, emRiboSeq, we map the genome-wide contribution of polymerases, and show that despite Okazaki fragment processing, DNA synthesized by error-prone polymerase-alpha (Pol-alpha) is retained in vivo, comprising approximately 1.5% of the mature genome. We propose that DNA-binding proteins that rapidly re-associate post-replication act as partial barriers to Pol-delta-mediated displacement of Pol-alpha-synthesized DNA, resulting in incorporation of such Pol-alpha tracts and increased mutation rates at specific sites. We observe a mutational cost to chromatin and regulatory protein binding, resulting in mutation hotspots at regulatory elements, with signatures of this process detectable in both yeast and humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reijns, Martin A M -- Kemp, Harriet -- Ding, James -- de Proce, Sophie Marion -- Jackson, Andrew P -- Taylor, Martin S -- MC_PC_U127580972/Medical Research Council/United Kingdom -- MC_PC_U127597124/Medical Research Council/United Kingdom -- MC_U127597124/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- England -- Nature. 2015 Feb 26;518(7540):502-6. doi: 10.1038/nature14183. Epub 2015 Jan 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical and Developmental Genetics, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. ; Biomedical Systems Analysis, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25624100" target="_blank"〉PubMed〈/a〉
Keywords: Binding Sites ; Chromatin/chemistry/metabolism ; Conserved Sequence/genetics ; DNA/*biosynthesis/*genetics ; DNA Polymerase I/metabolism ; DNA Polymerase III/metabolism ; DNA Replication/*genetics ; DNA-Binding Proteins/metabolism ; Evolution, Molecular ; Genome, Human/*genetics ; Humans ; Models, Biological ; Mutagenesis/genetics ; Mutation/*genetics ; Protein Binding ; Saccharomyces cerevisiae/genetics ; Transcription Factors/metabolism
Genome-wide association study identifies 74 loci associated with educational attainment (2016)
A. Okbay ; J. P. Beauchamp ; M. A. Fontana ; [et al.] J. J. Lee ; T. H. Pers ; C. A. Rietveld ; P. Turley ; G. B. Chen ; V. Emilsson ; S. F. Meddens ; S. Oskarsson ; J. K. Pickrell ; K. Thom ; P. Timshel ; R. de Vlaming ; A. Abdellaoui ; ... and further 238
Description: Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okbay, Aysu -- Beauchamp, Jonathan P -- Fontana, Mark Alan -- Lee, James J -- Pers, Tune H -- Rietveld, Cornelius A -- Turley, Patrick -- Chen, Guo-Bo -- Emilsson, Valur -- Meddens, S Fleur W -- Oskarsson, Sven -- Pickrell, Joseph K -- Thom, Kevin -- Timshel, Pascal -- de Vlaming, Ronald -- Abdellaoui, Abdel -- Ahluwalia, Tarunveer S -- Bacelis, Jonas -- Baumbach, Clemens -- Bjornsdottir, Gyda -- Brandsma, Johannes H -- Pina Concas, Maria -- Derringer, Jaime -- Furlotte, Nicholas A -- Galesloot, Tessel E -- Girotto, Giorgia -- Gupta, Richa -- Hall, Leanne M -- Harris, Sarah E -- Hofer, Edith -- Horikoshi, Momoko -- Huffman, Jennifer E -- Kaasik, Kadri -- Kalafati, Ioanna P -- Karlsson, Robert -- Kong, Augustine -- Lahti, Jari -- van der Lee, Sven J -- deLeeuw, Christiaan -- Lind, Penelope A -- Lindgren, Karl-Oskar -- Liu, Tian -- Mangino, Massimo -- Marten, Jonathan -- Mihailov, Evelin -- Miller, Michael B -- van der Most, Peter J -- Oldmeadow, Christopher -- Payton, Antony -- Pervjakova, Natalia -- Peyrot, Wouter J -- Qian, Yong -- Raitakari, Olli -- Rueedi, Rico -- Salvi, Erika -- Schmidt, Borge -- Schraut, Katharina E -- Shi, Jianxin -- Smith, Albert V -- Poot, Raymond A -- St Pourcain, Beate -- Teumer, Alexander -- Thorleifsson, Gudmar -- Verweij, Niek -- Vuckovic, Dragana -- Wellmann, Juergen -- Westra, Harm-Jan -- Yang, Jingyun -- Zhao, Wei -- Zhu, Zhihong -- Alizadeh, Behrooz Z -- Amin, Najaf -- Bakshi, Andrew -- Baumeister, Sebastian E -- Biino, Ginevra -- Bonnelykke, Klaus -- Boyle, Patricia A -- Campbell, Harry -- Cappuccio, Francesco P -- Davies, Gail -- De Neve, Jan-Emmanuel -- Deloukas, Panos -- Demuth, Ilja -- Ding, Jun -- Eibich, Peter -- Eisele, Lewin -- Eklund, Niina -- Evans, David M -- Faul, Jessica D -- Feitosa, Mary F -- Forstner, Andreas J -- Gandin, Ilaria -- Gunnarsson, Bjarni -- Halldorsson, Bjarni V -- Harris, Tamara B -- Heath, Andrew C -- Hocking, Lynne J -- Holliday, Elizabeth G -- Homuth, Georg -- Horan, Michael A -- Hottenga, Jouke-Jan -- de Jager, Philip L -- Joshi, Peter K -- Jugessur, Astanand -- Kaakinen, Marika A -- Kahonen, Mika -- Kanoni, Stavroula -- Keltigangas-Jarvinen, Liisa -- Kiemeney, Lambertus A L M -- Kolcic, Ivana -- Koskinen, Seppo -- Kraja, Aldi T -- Kroh, Martin -- Kutalik, Zoltan -- Latvala, Antti -- Launer, Lenore J -- Lebreton, Mael P -- Levinson, Douglas F -- Lichtenstein, Paul -- Lichtner, Peter -- Liewald, David C M -- LifeLines Cohort Study -- Loukola, Anu -- Madden, Pamela A -- Magi, Reedik -- Maki-Opas, Tomi -- Marioni, Riccardo E -- Marques-Vidal, Pedro -- Meddens, Gerardus A -- McMahon, George -- Meisinger, Christa -- Meitinger, Thomas -- Milaneschi, Yusplitri -- Milani, Lili -- Montgomery, Grant W -- Myhre, Ronny -- Nelson, Christopher P -- Nyholt, Dale R -- Ollier, William E R -- Palotie, Aarno -- Paternoster, Lavinia -- Pedersen, Nancy L -- Petrovic, Katja E -- Porteous, David J -- Raikkonen, Katri -- Ring, Susan M -- Robino, Antonietta -- Rostapshova, Olga -- Rudan, Igor -- Rustichini, Aldo -- Salomaa, Veikko -- Sanders, Alan R -- Sarin, Antti-Pekka -- Schmidt, Helena -- Scott, Rodney J -- Smith, Blair H -- Smith, Jennifer A -- Staessen, Jan A -- Steinhagen-Thiessen, Elisabeth -- Strauch, Konstantin -- Terracciano, Antonio -- Tobin, Martin D -- Ulivi, Sheila -- Vaccargiu, Simona -- Quaye, Lydia -- van Rooij, Frank J A -- Venturini, Cristina -- Vinkhuyzen, Anna A E -- Volker, Uwe -- Volzke, Henry -- Vonk, Judith M -- Vozzi, Diego -- Waage, Johannes -- Ware, Erin B -- Willemsen, Gonneke -- Attia, John R -- Bennett, David A -- Berger, Klaus -- Bertram, Lars -- Bisgaard, Hans -- Boomsma, Dorret I -- Borecki, Ingrid B -- Bultmann, Ute -- Chabris, Christopher F -- Cucca, Francesco -- Cusi, Daniele -- Deary, Ian J -- Dedoussis, George V -- van Duijn, Cornelia M -- Eriksson, Johan G -- Franke, Barbara -- Franke, Lude -- Gasparini, Paolo -- Gejman, Pablo V -- Gieger, Christian -- Grabe, Hans-Jorgen -- Gratten, Jacob -- Groenen, Patrick J F -- Gudnason, Vilmundur -- van der Harst, Pim -- Hayward, Caroline -- Hinds, David A -- Hoffmann, Wolfgang -- Hypponen, Elina -- Iacono, William G -- Jacobsson, Bo -- Jarvelin, Marjo-Riitta -- Jockel, Karl-Heinz -- Kaprio, Jaakko -- Kardia, Sharon L R -- Lehtimaki, Terho -- Lehrer, Steven F -- Magnusson, Patrik K E -- Martin, Nicholas G -- McGue, Matt -- Metspalu, Andres -- Pendleton, Neil -- Penninx, Brenda W J H -- Perola, Markus -- Pirastu, Nicola -- Pirastu, Mario -- Polasek, Ozren -- Posthuma, Danielle -- Power, Christine -- Province, Michael A -- Samani, Nilesh J -- Schlessinger, David -- Schmidt, Reinhold -- Sorensen, Thorkild I A -- Spector, Tim D -- Stefansson, Kari -- Thorsteinsdottir, Unnur -- Thurik, A Roy -- Timpson, Nicholas J -- Tiemeier, Henning -- Tung, Joyce Y -- Uitterlinden, Andre G -- Vitart, Veronique -- Vollenweider, Peter -- Weir, David R -- Wilson, James F -- Wright, Alan F -- Conley, Dalton C -- Krueger, Robert F -- Davey Smith, George -- Hofman, Albert -- Laibson, David I -- Medland, Sarah E -- Meyer, Michelle N -- Yang, Jian -- Johannesson, Magnus -- Visscher, Peter M -- Esko, Tonu -- Koellinger, Philipp D -- Cesarini, David -- Benjamin, Daniel J -- P01-AG005842/AG/NIA NIH HHS/ -- P01-AG005842-20S2/AG/NIA NIH HHS/ -- P30-AG012810/AG/NIA NIH HHS/ -- R01-AG042568/AG/NIA NIH HHS/ -- T32-AG000186-23/AG/NIA NIH HHS/ -- England -- Nature. 2016 May 11;533(7604):539-42. doi: 10.1038/nature17671.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands. ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands. ; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands. ; Department of Economics, Harvard University, Cambridge, Massachusetts 02138, USA. ; Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA. ; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA. ; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 2116, USA. ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA. ; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen 2100, Denmark. ; Statens Serum Institut, Department of Epidemiology Research, Copenhagen 2300, Denmark. ; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. ; Icelandic Heart Association, Kopavogur 201, Iceland. ; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik 107, Iceland. ; Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands. ; Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands. ; Department of Government, Uppsala University, Uppsala 751 20, Sweden. ; New York Genome Center, New York, New York 10013, USA. ; Department of Economics, New York University, New York, New York 10012, USA. ; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark Lyngby 2800, Denmark. ; Department of Biological Psychology, VU University Amsterdam, Amsterdam, 1081 BT, The Netherlands. ; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark. ; Steno Diabetes Center, Gentofte 2820, Denmark. ; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg 416 85, Sweden. ; Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. ; Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. ; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland. ; Department of Cell Biology, Erasmus Medical Center Rotterdam, 3015 CN, The Netherlands. ; Istituto di Ricerca Genetica e Biomedica U.O.S. di Sassari, National Research Council of Italy, Sassari 07100, Italy. ; Psychology, University of Illinois, Champaign, Illinois 61820, USA. ; 23andMe, Inc., Mountain View, California 94041, USA. ; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands. ; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy. ; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. ; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK. ; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK. ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. ; Department of Neurology, General Hospital and Medical University Graz, Graz 8036, Austria. ; Institute for Medical Informatics, Statistics and Documentation, General Hospital and Medical University Graz, Graz 8036, Austria. ; Oxford Centre for Diabetes, Endocrinology &Metabolism, University of Oxford, Oxford OX3 7LE, UK. ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. ; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. ; Institute of Behavioural Sciences, University of Helsinki, 00014 Helsinki, Finland. ; Nutrition and Dietetics, Health Science and Education, Harokopio University, Athens 17671, Greece. ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden. ; Folkhalsan Research Centre, 00014 Helsingfors, Finland. ; Institute for Computing and Information Sciences, Radboud University Nijmegen, Nijmegen, 6525 EC, The Netherlands. ; Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. ; Lifespan Psychology, Max Planck Institute for Human Development, Berlin 14195, Germany. ; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK. ; NIHR Biomedical Research Centre, Guy's and St. Thomas' Foundation Trust, London SE1 7EH, UK. ; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands. ; Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia. ; Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300, Australia. ; Centre for Integrated Genomic Medical Research, Institute of Population Health, The University of Manchester, Manchester M13 9PT, UK. ; Human Communication and Deafness, School of Psychological Sciences, The University of Manchester, Manchester M13 9PL, UK. ; Department of Health, THL-National Institute for Health and Welfare, 00271 Helsinki, Finland. ; Psychiatry, VU University Medical Center &GGZ inGeest, Amsterdam, 1081 HL, The Netherlands. ; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA. ; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20521 Turku, Finland. ; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland. ; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland. ; Department Of Health Sciences, University of Milan, Milano 20142, Italy. ; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen 45147, Germany. ; Centre for Global Health Research, The Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9780, USA. ; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland. ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. ; School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK. ; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany. ; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands. ; Institute of Epidemiology and Social Medicine, University of Munster, Munster 48149, Germany. ; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02115, USA. ; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA. ; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. ; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA. ; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands. ; Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg D-93053, Germany. ; Institute of Molecular Genetics, National Research Council of Italy, Pavia 27100, Italy. ; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. ; Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. ; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK. ; Said Business School, University of Oxford, Oxford OX1 1HP, UK. ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. ; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia. ; The Berlin Aging Study II; Research Group on Geriatrics, Charite - Universitatsmedizin Berlin, Germany, Berlin 13347, Germany. ; Institute of Medical and Human Genetics, Charite-Universitatsmedizin, Berlin, Berlin 13353, Germany. ; German Socio- Economic Panel Study, DIW Berlin, Berlin 10117, Germany. ; Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. ; The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, QLD 4102, Australia. ; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48109, USA. ; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri 63018, USA. ; Institute of Human Genetics, University of Bonn, Bonn 53127, Germany. ; Department of Genomics, Life and Brain Center, University of Bonn, Bonn 53127, Germany. ; Institute of Biomedical and Neural Engineering, School of Science and Engineering, Reykjavik University, Reykjavik 101, Iceland. ; Laboratory of Epidemiology, Demography, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892-9205, USA. ; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. ; Division of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK. ; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany. ; Manchester Medical School, The University of Manchester, Manchester M13 9PT, UK. ; Program in Translational NeuroPsychiatric Genomics, Departments of Neurology &Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ; Harvard Medical School, Boston, Massachusetts 02115, USA. ; Department of Genes and Environment, Norwegian Institute of Public Health, N-0403 Oslo, Norway. ; Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK. ; Department of Clinical Physiology, Tampere University Hospital, 33521 Tampere, Finland. ; Department of Clinical Physiology, University of Tampere, School of Medicine, 33014 Tampere, Finland. ; Public Health, Medical School, University of Split, 21000 Split, Croatia. ; Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne 1010, Switzerland. ; Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892-9205, USA. ; Amsterdam Brain and Cognition Center, University of Amsterdam, Amsterdam, 1018 XA, The Netherlands. ; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305-5797, USA. ; Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. ; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. ; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne 1011, Switzerland. ; Tema BV, Hoofddorp, 2131 HE, The Netherlands. ; Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. ; Institute of Health and Biomedical Innovation, Queensland Institute of Technology, Brisbane, QLD 4059, Australia. ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. ; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA. ; Psychiatric &Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. ; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. ; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. ; Medical Genetics, Institute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste 34100, Italy. ; Social Impact, Arlington, Virginia 22201, USA. ; Department of Economics, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA. ; Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois 60201-3137, USA. ; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA. ; Public Health Genomics Unit, National Institute for Health and Welfare, 00300 Helsinki, Finland. ; Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, General Hospital and Medical University, Graz, Graz 8010, Austria. ; Information Based Medicine Stream, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia. ; Medical Research Institute, University of Dundee, Dundee DD1 9SY, UK. ; Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Science, University of Leuven, Leuven 3000, Belgium. ; R&D VitaK Group, Maastricht University, Maastricht, 6229 EV, The Netherlands. ; Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. ; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig Maximilians-Universitat, Munich 81377, Germany. ; Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida 32306, USA. ; Department of Health Sciences and Genetics, University of Leicester, Leicester LE1 7RH, UK. ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands. ; Research Center for Group Dynamics, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA. ; Platform for Genome Analytics, Institutes of Neurogenetics &Integrative and Experimental Genomics, University of Lubeck, Lubeck 23562, Germany. ; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK. ; Department of Health Sciences, Community &Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9713 AV, The Netherlands. ; Department of Psychology, Union College, Schenectady, New York 12308, USA. ; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 9042, Italy. ; Institute of Biomedical Technologies, Italian National Research Council, Segrate (Milano) 20090, Italy. ; Department of General Practice and Primary Health Care, University of Helsinki, 00014 Helsinki, Finland. ; Departments of Human Genetics and Psychiatry, Donders Centre for Neuroscience, Nijmegen, 6500 HB, The Netherlands. ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands. ; Sidra, Experimental Genetics Division, Sidra, Doha 26999, Qatar. ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald 17475, Germany. ; Department of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, Stralsund 18437, Germany. ; Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands. ; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, 1105 AZ, The Netherlands. ; Generation Scotland, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. ; Centre for Population Health Research, School of Health Sciences and Sansom Institute, University of South Australia, Adelaide, SA 5000, Australia. ; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia. ; Population, Policy and Practice, UCL Institute of Child Health, London WC1N 1EH, UK. ; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment &Health, School of Public Health, Imperial College London, London W2 1PG, UK. ; Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland. ; Unit of Primary Care, Oulu University Hospital, 90029 Oulu, Finland. ; Biocenter Oulu, University of Oulu, 90014 Oulu, Finland. ; Fimlab Laboratories, 33520 Tampere, Finland. ; Department of Clinical Chemistry, University of Tampere, School of Medicine, 33014 Tampere, Finland. ; Economics, NYU Shanghai, 200122 Pudong, China. ; Policy Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada. ; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. ; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia. ; Centre for Clinical and Cognitive Neuroscience, Institute Brain Behaviour and Mental Health, Salford Royal Hospital, Manchester M6 8HD, UK. ; Manchester Institute for Collaborative Research in Ageing, University of Manchester, Manchester M13 9PL, UK. ; Faculty of Medicine, University of Split, Split 21000, Croatia. ; Department of Clinical Genetics, VU Medical Centre, Amsterdam, 1081 HV, The Netherlands. ; Institute of Preventive Medicine. Bispebjerg and Frederiksberg Hospitals, The Capital Region, Frederiksberg 2000, Denmark. ; Montpellier Business School, Montpellier 34080, France. ; Panteia, Zoetermeer, 2715 CA, The Netherlands. ; Department of Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands. ; Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands. ; Department of Sociology, New York University, New York, New York 10012, USA. ; School of Medicine, New York University, New York, New York 10016, USA. ; Bioethics Program, Union Graduate College - Icahn School of Medicine at Mount Sinai, Schenectady, New York 12308, USA. ; Department of Economics, Stockholm School of Economics, Stockholm 113 83, Sweden. ; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Research Institute for Industrial Economics, Stockholm 10215, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27225129" target="_blank"〉PubMed〈/a〉
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA (2011)
Y. F. He ; B. Z. Li ; Z. Li ; [et al.] P. Liu ; Y. Wang ; Q. Tang ; J. Ding ; Y. Jia ; Z. Chen ; L. Li ; Y. Sun ; X. Li ; Q. Dai ; C. X. Song ; K. Zhang ; C. He ; ... and further 1
In: Science. 333(6047): 1303-7. doi: 10.1126/science.1210944.
Description: The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) family of dioxygenases. Despite their importance in epigenetic regulation, it is unclear how these cytosine modifications are reversed. Here, we demonstrate that 5mC and 5hmC in DNA are oxidized to 5-carboxylcytosine (5caC) by Tet dioxygenases in vitro and in cultured cells. 5caC is specifically recognized and excised by thymine-DNA glycosylase (TDG). Depletion of TDG in mouse embyronic stem cells leads to accumulation of 5caC to a readily detectable level. These data suggest that oxidation of 5mC by Tet proteins followed by TDG-mediated base excision of 5caC constitutes a pathway for active DNA demethylation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462231/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462231/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Yu-Fei -- Li, Bin-Zhong -- Li, Zheng -- Liu, Peng -- Wang, Yang -- Tang, Qingyu -- Ding, Jianping -- Jia, Yingying -- Chen, Zhangcheng -- Li, Lin -- Sun, Yan -- Li, Xiuxue -- Dai, Qing -- Song, Chun-Xiao -- Zhang, Kangling -- He, Chuan -- Xu, Guo-Liang -- 1S10RR027643-01/RR/NCRR NIH HHS/ -- GM071440/GM/NIGMS NIH HHS/ -- R01 GM071440/GM/NIGMS NIH HHS/ -- S10 RR027643/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1303-7. doi: 10.1126/science.1210944. Epub 2011 Aug 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Group of DNA Metabolism, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817016" target="_blank"〉PubMed〈/a〉
Keywords: 5-Methylcytosine/metabolism ; Animals ; Cell Line ; Cytosine/*analogs & derivatives/metabolism ; DNA/*metabolism ; DNA Methylation ; DNA-Binding Proteins/genetics/*metabolism ; Embryonic Stem Cells ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mice ; Oxidation-Reduction ; Proto-Oncogene Proteins/genetics/*metabolism ; RNA, Small Interfering ; Thymine DNA Glycosylase/genetics/*metabolism ; Transfection
Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
Ultralarge elastic deformation of nanoscale diamond (2018)
Banerjee, A., Bernoulli, D., Zhang, H., Yuen, M.-F., Liu, J., Dong, J., Ding, F., Lu, J., Dao, M., Zhang, W., Lu, Y., Suresh, S.
In: Science
Description: Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully reversible elastic deformation of nanoscale (~300 nanometers) single-crystalline and polycrystalline diamond needles. For single-crystalline diamond, the maximum tensile strains (up to 9%) approached the theoretical elastic limit, and the corresponding maximum tensile stress reached ~89 to 98 gigapascals. After combining systematic computational simulations and characterization of pre- and postdeformation structural features, we ascribe the concurrent high strength and large elastic strain to the paucity of defects in the small-volume diamond nanoneedles and to the relatively smooth surfaces compared with those of microscale and larger specimens. The discovery offers the potential for new applications through optimized design of diamond nanostructure, geometry, elastic strains, and physical properties.
Keywords: Engineering, Materials Science
Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
Prognostic value of ki67 in BCG-treated non-muscle invasive bladder cancer: a meta-analysis and systematic review (2018)
He, Y., Wang, N., Zhou, X., Wang, J., Ding, Z., Chen, X., Deng, Y.
BMJ Publishing
In: BMJ Open
Description: Objectives The aim of this study was to explore the prognostic value of ki67 as a marker in patients with non-muscle invasive bladder cancer (NMIBC) treated with BCG. Methods Studies were systematically retrieved from the relevant databases (Web of Science, PubMed, Cochrane Library and Embase), and the expiry date was May 2017. The research steps referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Results A total of 11 studies that complied with the inclusion criteria were included. The expression of ki67 was not statistically significantly associated with recurrence-free survival (RFS) (HR 1.331; 95% CI 0.980 to 1.809). No significant heterogeneity was found among all included studies ( I 2 =36.7%, p=0.148). The expression of ki67 was statistically significantly associated with progression-free survival (PFS) (HR 2.567; 95% CI 1.562 to 4.219), and the overexpression of ki67 was the risk factor for PFS. Significant heterogeneity was noted among all the included studies ( I 2 =55.6%, p=0.021). The studies that might cause heterogeneity were excluded using the Galbraith plot, and then the meta-analysis was performed again. The results showed that the expression of ki67 was still associated with PFS (HR 2.922; 95% CI 2.002 to 4.266). Conclusions The overexpression of ki67 was the risk factor for PFS, and the relationship between the expression of ki67 and RFS was not statistically significant in patients with NMIBC treated with BCG intravesical immunotherapy. Well-designed, prospective, with a large sample size are still needed to validate the findings.
Keywords: Open access, Urology
Published by BMJ Publishing


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Archive 2012 >
UC project on fielding in one day cricket matches
A University of Canterbury research project will later this year study the benefits of fielding in one day international cricket (ODI) matches.
UC, two years on since the first big earthquake
Two years on since the first big Christchurch earthquake of September 4 2010, the University of Canterbury has demonstrated that it has made great strides.
UC research to look into ChCh cathedral row
Christchurch Cathedral is so pivotal and important to the city that a University of Canterbury academic has launched a research project into the significance of the church.
UC re-launching its journalism course in 2013
The University of Canterbury is re-launching its journalism course, which was not offered in 2012 in the wake of the Canterbury earthquakes.
PhD students' game to feature in US showcase
Two UC PhD students are fine turning their world-first geothermal computer game for the international serious games showcase and challenge in the US in December.
UC student wins Dragon's Den style competition
A University of Canterbury student is the New Zealand winner of Australasian competition Big Break Project, a difficult Dragon's Den style tertiary business competition.
Testing pipes at three times the speed of sound
Ground-breaking University of Canterbury research could soon be a life saver in testing damaged pipelines, around New Zealand and overseas, at three times the speed of sound.
Speed cameras will help but not a silver bullet
More speed cameras will cut down speeds but they are not the silver bullet for safety on New Zealand's roads, says a University of Canterbury researcher.
UC approves 190 summer research scholarships
A total of 190 projects have been awarded University of Canterbury (UC) summer research scholarships, each valued at $5000.
UC-born robot company wins major NZ business award
University of Canterbury-born company Invert Robotics has won the annual ANZ Flying Start Business Plan's supreme award and $56,000 in prizes.
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redpajama_set_name: RedPajamaCommonCrawl


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We hope you have a fine start to summer and find time to enjoy our 50th offering.
Benjamin Evans
Executive Editor, Fogged Clarity
Benjamin RoeschBenjamin Roesch is an author living and teaching in Burlington, Vermont. His short fiction has appeared in Word Riot, Brilliant Corners, Monkey Bicycle and Seven Days. He was selected as a Fiction Contributor for the 2011 Bread Loaf Writers' Conference.Who Has Time for Stars?
Yvonne ZipterYvonne Zipter is the author of two full-length collections of poetry: As If the Night Could Heal Itself and The Patience of Metal. Her 2006 chapbook, Like Some Bookie God was nominated for a Dog Writer's Association of America award. Her poems have appeared in Poetry, Spoon River Poetry Review, Calyx, Crab Orchard Review and Bellingham Review, among many other publications. She is a recipient of the Sprague-Todes Literary Award and an Illinois Arts Council Finalist Award for nonfiction.Kissing, Fire
Hilary SiderisHilary Sideris holds an MFA from The Writers' Workshop at The University of Iowa. Her poems have appeared in Arts & Letters, Barrow Street, The Cortland Review, Mid-American Review, The Southern Poetry Review and Swink, among other publications. She is the author of the chapbooks The Orange Juice is Over, Gold & Other Fish, Sweet Flag, Baby and A House Not Made with Hands. She currently lives and works in Brooklyn.Boss
Simon PerchikSimon Perchik is an attorney whose poems have appeared in Partisan Review, The Nation, The New Yorker, and elsewhere. For more information, including free e-books, his essay titled "Magic, Illusion and Other Realities" and a complete bibliography, please visit his website at www.simonperchik.com.Untitled Sequence
klipschutzklipschutz (pen name of Kurt Lipschutz) is a poet, songwriter and occasional freelance journalist, based in San Francisco. His new book of poems, This Drawn & Quartered Moon, was released by Anvil Press in April 2013.South-Facing Window, Four A.M.
Mountain SoundsMountain Sounds is Oregon musician Tim Hoyt and Guatemalan musician Franc Castillejos.Mountain Sounds
The Fogged Clarity Session
Scott HightowerScott Hightower is an award winning poet, translator, and the author of four books. This fall, Hontanares/Fountains, a bi-lingual book, is forthcoming from Devenir, Madrid. Hightower teaches as adjunct faculty at NYU. A native of central Texas, he lives in Manhattan and sojourns in Spain.Sean Nevin's "Oblivio Gate"
California Line


For more than a century, professional wrestling has had men of all shapes and sizes compete in that squared circle. Fat men, thin men. Muscular men, out of shape men. Little men, big men. Perhaps two of the best big men of all time are "King Kong" Bruiser Brody and the Undertaker.
Unfortunately they were a generation or more a part in terms their time in the ring. Undertaker was just starting out around the time of Brody's death. But these two did actually meet in the ring when they both worked for World Class Championship Wrestling. The Undertaker donned a mask and wrestled as "Texas Red."
It was a sloppy encounter, and one of Taker's first matches. I dispute the date on this YouTube video though. The Internet is a great resource for information, but there are conflicting reports on the Undertaker's actual debut. At the end of this match they flash a graphic for Eric Embry appearing on the show, as well as Steve Simpson. If my memory is correct, neither man was a part of WCCW in 1984.
Brody obviously went over in this confrontation. As most of you probably remember, the Undertaker was basically a big man jobber until he hit it big in the WWF in 1990. Although as the Punisher in WCCW he had some success. His stint in WCW was less than memorable.
By the time the Undertaker had debuted in the WWF, Brody had been dead for more than two years, the victim of a locker room stabbing. Brody was also about 20 years Undertaker's elder, so if the two had ever met again, Brody would have been on his way down the ladder, with Taker just starting his climb to the top.
Even though Brody never wore the NWA, AWA, or WWF world heavyweight titles, the big man did pick up gold in other territories and around the world. Clearly he was an international star and wrestled big names like Ric Flair, Harley Race, and Verne Gagne back in the day. He reminded me a lot of Andre the Giant, in that he did not need a belt to prove his worth in the ring. I recently wrote a post about Brody on the anniversary of his untimely death.
Undertaker in the last 20 years has proven he may very well be the best of the big men to even step into the ring. Even with his body breaking down before our very eyes, he's able to put on an exciting match (albeit somewhat predictable) Imagine mid 80's Brody facing mid 90's Undertaker. As Gorilla Monsoon would say, "this match would be the main event in any arena."
While I think Brody was always an incredible worker, I'd give the slight edge in this battle to the Undertaker. Although more likely if this match were to happen, it would go to a double disqualification, but in the world of Fantasy Friday, we have to pick a winner. So, I'm going to give the Undertaker the win, but this is by far the closest Fantasy Friday match I've booked.
What are your thoughts? Who would win this epic fantasy battle? I'm curious to hear. Post your ideas here or on Facebook, Twitter, or YouTube.


TRX is a body weight suspension training system that was created and designed by a former Navy Seal. Suspension training uses a TRX strap suspended from the ceiling to allow the student to work against their own body weight. This method allows you to build strength, balance, flexibility, and joint stability quickly and easily. Because of its demands on the core, TRX Suspension Training essentially turns every movement into a total-body exercise, reducing the chance of injury, and increasing metabolic rates dramatically.
For Group Classes at Total Fitness, you have a few options based on your usage. Bronze Level is $50/month and gives you up to 12 classes. Silver Level is $75/month and gives you up to 20 classes. Gold Level is $100/month and gives you unlimited classes. We have 25-30 classes/weekly to choose from, including: TRX, Contact Kickboxing, Yoga, Fitness, Strength, Spinning, and more! You also have the option to drop-in to a class for $10 or purchase a 5 or 10-class package for your classes.
At Total Fitness, we have a shock absorbing floor in our TRX training room. So not only are you able to strengthen your entire body, but you can do so without risk of injury to your joints.
Contact kickboxing is a fun and amazing partner workout that focuses on cardio, strength, and core. Using gloves and pads, you will punch, kick, hook, and uppercut, all while the instructor teaches you the proper techniques. The high intensity intervals of Contact Kickboxing keep you burning fat and calories the whole time. And the physical contact means you will get more out of your workout. This partner workout is guaranteed to include hard work, sweat, laughter, and fun.
At Total Fitness, we have a shock absorbing floor in our TRX training room so not only are you able to strengthen your entire body, but you can do so without risk of injury to your knees and hips.
With TRX you can minimize your training time by working your entire body, and switching from one exercise to the next in just seconds. TRX exercises are designed to engage your core, which means involving the pelvis, abs, back and chest muscles. It is our core that gives the body stability, balance and flexibility. An additional benefit of using gravity and your body weight is that you are able to modify your own personal fitness difficulty just by walking yourself closer or further away from the anchor point of the TRX system.
Contact kickboxing also works your entire body with a strong emphasis on cardiovascular, endurance, core strength, and hand-eye coordination.
An ultimate body weight workout that increases strength, flexibility, and athletic performance.
All levels of fitness benefit from TRX and contact kickboxing.
A Total Body workout including speed, agility, stability, balance, core, strength, and flexibility.
Recover from injuries including shoulder and lower back problems.
Fast, effective, powerful, and fun workout.
Contact us today to get started with TRX suspension training and contact kickboxing. You can strengthen your body and stabilize your core. And you can do it on a shock absorbing floor with a community of other people who simply want to get healthier and improve themselves.
Total Fitness is located in Cambridge, MN and has many TRX training participants from around the area, including Isanti, Braham, Bethel, East Bethel, and Ham Lake.


text:
Dianna's Way is a true story about a remarkable woman's irrepressible love of life, of a man and a woman's enduring love for each other and their spiritual journey.
The story begins at a party when John, a man in his late 40's, sees Dianna, a young woman in her late 20's. He is enthralled by her beauty, radiance, and ineffable sense of mystery. Dianna "is in Technicolor and everyone else is in black and white." They fall in love and marry.
Not long into their marriage, they discover she has an aggressive form of breast cancer, beginning a seventeen year odyssey into the unknown. Expecting to be the teacher, not the student, John is humbled by the gradual discovery the opposite is true, in their marriage and in life. The author accompanies her each step of the way, profoundly awed by Dianna's courage, determination, and lightness of being, increasingly amazed by the undeniable healing affect she has on others. Along the way, she fulfills her life purpose and, in the process, helps John to discover then fulfill his own.
Theirs is a story of courage and determination laced with humor as they descend into the deepest valleys of disappointment, pain and despair only to rise again to ever higher peaks of appreciation, gratitude and love, an exploration into the nature of love, healing and transformation. Even after her passing, their relationship pierces the illusion veiling this reality.
Dianna's Way challenges us to consider a model for living beyond the usual drama manufactured by shame, guilt, regret and fear of survival.
What does it mean to be human? What daily practices create a life that works? If we knew our significant relationships were designed in spirit, how might we live them more fully? How can we meet the challenges of disappointment, illness, loss, yet still rise to our own highest potential?
Dianna's Way, a story sprinkled with laughter and marinated in the gentleness of Dianna's spirit, explores these questions.
It is a story about an ordinary human being who chose to live an extraordinary life.
Copyright © 2016 · All Rights Reserved · John Catenacci


In 2018, California passed a portentous milestone: It had been 100 years since the last major earthquake struck one of the state's three most notorious faults. Now a new study analyzing paleoseismic records along the San Andreas, San Jacinto, and Hayward Faults has shown that the 100-year earthquake-free hiatus is unprecedented in the past 10 centuries.
In 2014, University of California, Los Angeles geophysicist David Jackson presented a talk at a Seismological Society of America conference cleverly titled "Did Somebody Forget to Pay the Earthquake Bill?," which called attention to the lack of major seismic activity at paleoseismic sites around California. At the time, Jackson suggested that the gap could be a normal statistical occurrence if paleoseismologists had systematically overestimated the number of past earthquakes.
Paleoseismic records are gleaned by digging shallow trenches that expose scars from past earthquakes that have ruptured from the depths of a fault to the surface. To determine the likelihood of a 100-year hiatus, Glenn Biasi and Katherine Scharer, both at the U.S. Geological Survey (USGS) in Pasadena, Calif., analyzed previously published paleoseismic records from 12 locations along the San Andreas, San Jacinto, and Hayward Faults.
Biasi and Scharer found that the hiatus is highly unlikely, with a 0.3% chance of being a statistical fluke.
The new study, published in Seismological Research Letters, does not attempt to explain the hiatus.
Biasi says one possible explanation is that the eight major earthquakes that occurred between 1800 and 1918 may have relieved all the accumulated strain and set the faults up for a quiet century.
Another possible explanation is that faults throughout the state may be more interconnected than we realize. "Last century, all these faults ruptured together, and now they're all being quiet together," Biasi says.
It's unlikely that the new study will affect current earthquake forecasts for the next century, says Ned Field, a geophysicist at the USGS Geologic Hazards Science Center in Golden, Colo., who was not involved in the study.
"I don't think anybody would say this overturns the practical implications of our latest model, but it does point out there might be something missing in our understanding of this system as a whole," Field says.
One possible impact could influence the Uniform California Earthquake Rupture Forecast, Version 3, developed by Field and used by the USGS to model hazard estimates for the state. The forecast does not take into account the relationships between parallel, adjacent faults, like the San Andreas and Hayward.
"If you have a big earthquake on the San Andreas, another fault that parallels it could be shut down in a way that the model doesn't presently acknowledge," Field says.
"Given what we know of the last 1,000 years of activity along these faults, it's likely that the next century is going to busier than this last century," Biasi says.
The long-term averages suggest that around three to four major ground-rupturing events should occur throughout the state each century. "These averages mean that the system has some catching up to do, but we don't know where or when that will happen," Biasi says.
Citation: Morton, M. C. (2019), Reassessing California's overdue earthquake tab, Eos, 100, https://doi.org/10.1029/2019EO120767. Published on 12 April 2019.


text:
Home Dining Primebar Calls It Quits
Primebar Calls It Quits
by George Mahe
Two guys walk into a bar on Sunday night and order a couple of beers. The bartender serves them, excuses himself, and returns "with much different body language," and tells the guys they might want to finish them up as the bar is "closing early.tonight." Little did they know the bar would be closing for good. Right after they left.
The bar is Primebar in Des Peres and the guys were two cooks from McCormick & Schmick's enjoying a cold one after work. Apparently, the bartender had just been informed by the just-arrived VP of Operations that Primebar was calling it quits. Right then. PrimeBar is owned by Restaurants-America (the company that originally launched Bar Louie), and, according to their website, has 5 other units in 4 other states. .
I remember when I first discovered Primebar was coming to West County Center. News was sketchy, even after the lease was signed. No one was talking, no phone calls were returned. I finally received a return call from their corporate marketing department a week after I posted this. That's a problem. Then the opening was delayed--for six weeks--and when it finally debuted on February 1, almost no one knew about it--It was the softest of soft openings. And no one ever really discovered it, in my opinion, despite a huge selection of beers and cheap (and decent) happy hour food. That's poor marketing folks. Poor planning. And when you're next door to chain behemoths like McCormick & Schmick's Seafood Restaurant and BRAVO! Cucina Italiana, you better be ready to slug it out with the big boys.
And here, I'll echo a sentiment that Joe Bonwich mentioned in this morning's announcement of the opening of another West County restaurant. Having a working, informative website up and running prior to opening day is an essential (and almost universally overlooked) aspect of operating a restaurant. A website is now THE principal source of information for today's diner, and if you're serious about opening a restaurant, get serious about its website. Early. And activate the restaurant's phone number while you're at it (even if only has a recorded message), then get a live human on the receiving end as soon as possible. Make some early friends. Create some buzz. Generate and maintain the public's interest, restaurateurs, and scribes like us will be more than happy to push the news along. Hire someone to do this. It's part of the dance. Or, you could end up like PrimeBar, never achieving critical mass. And now back to our regularly scheduled blogpost...
With four big, new restaurants opening in West County Center within 12 months of one another, it was only a matter of time before there would be some attrition. Hanley's Grille & Tap, off by itself at the less-traveled end of the complex, closed in June. And Primebar served its last beers last night.
Relish September 2010
George Mahe
Mahe is St. Louis Magazine's dining editor. Originally a finicky eater, he has owned or operated restaurants most of his life. He began reviewing them for SLM in 1991.
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The Picture here is of steering wheel of a Sauber C33. So, let's take a deeper look into this great piece of engineering.
The screen, which you seen in the picture is a PCU-8D LCD Screen, which has been made by the McLaren Electronics. The screen is 4.3 inches wide with a resolution of 480 x 272 pixels. It can display numerous pages of information such as lap count, lap times, split times, gear indicator and much other information.
This displays the engine lights and allows for optimal gear shifting as the lights give the driver indication when to shift to a higher gear. This also displays engine warnings.
The neutral button is yellow coloured (in here) and its function is to put the car into neutral from 1stgear. So, when the driver wants to engage neutral he has to keep the N button pressed and has to downshift beyond first gear to get into neural. If the N button is not pressed the gearbox won't downshift beyond 1st gear so it's a fail-safe mechanism to prevent engaging neutral during a race.
On reaching the DRS Zone if the driver is within limits to engage the DRS he gets a beep in his ear which confirms that he is within a second of the car ahead and can make use of the drag reduction system button to get closer to car ahead and maybe even overtake.
The box button, which is below the neutral, when pressed, informs the pit wall that the driver is going to come into the pits.
This adjusts the front and the rear brake balance.
These change the brake balance between a programmed position and the current BRKBAL rotary position.
This allows the driver to change the differential settings as he goes through different corners. Differential mainly helps adjust the speed at which different wheels rotate, like the speed of the left and the right wheel can be adjusted differently. The settings usually change from corner to corner but it also depends on how the driver likes the car to behave into the corner.
This is used to control the engine torque settings. Basically, controls the torque or the power being delivered by the engine. So, when the track conditions are poor such as during rain or when the track is new and greasy the driver can set the engine torque to a lower value which will allow for smoother drive. On the other hand if the track is offering good grip, the torque settings can be maximised to get the optimal performance.
The oil Button is used by the driver to activate the auxiliary oil tank for the engine. This is done when there is a failure of main oil pump.
This button is used to activate the clutch bite point find procedure. Finding the bite point is of utmost importance in making good starts of the line so finding the optimal bite point is very important and it differs from the circuit to circuit. The drivers usually find the clutch bite point during the three free practice sessions.
This is used to select the circumference of the tyre, and to adjust the electronics according to the different circumferences. So, there are different settings for each type of tyre. In the picture, you can also see the three colour coding red, yellow and green, these are used by the driver to indicate the degradation so that the pit crew can plan the strategy accordingly.
This is used to change the engine fuel mixture i.e more the fuel going into the engine more will be the power delivery. Therefore, this rotary dial is used to control the fuel consumption and so is of great importance strategy wise.
DIAG: Controls the default system.
PERF: Controls the engine modes.
ENG: Controls the Rev limiter.
CC: Cruise control; deactivated for qualifying and race.
SHIFT: Controls the shift type.
CLU: Controls clutch bite point offset.
VISCO: Differential corner exit setting.
BRK: Controls MGU-K(Motor Generator Unit) recovery limits.
BOOST: Controls MGU-K boost limits.
Pressing this button activates different settings, which give optimal performance required by the driver in case he needs to overtake the car in front.
This is used to change the pedal maps i.e when the driver presses on the accelerator pedal how much acceleration has to be offered or how much braking has to be applied when he presses on the brakes. Also, how much the driver has to press to get certain amount of acceleration and braking can also be set using this switch.
Controls the energy harvest system i.e the ERS. This switch is used to either generate or consume energy during a lap.
This button when pressed prevents the car from going above the pitlane speed limit.
This is used to put the car into the reverse gear. But the way in which this button works is similar to the working of the neutral button. So, when the driver want to engage the reverse gear he presses the R button and then downshifts using the downshift lever to the reverse gear. However, if the R button is not kept pressed the car won't downshift beyond first gear so it's a fail-safe system to prevent engagement of reverse gear during normal race proceedings.


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As we know that the colour of indian sideboard furniture really affect the whole style including the wall, decor style and furniture sets, so prepare your strategic plan about it. You can use the many colors choosing which provide the brighter colour schemes like off-white and beige colours. Combine the bright colour of the wall with the colorful furniture for gaining the harmony in your room. You can use the certain color choosing for giving the design ideas of each room in your home. A variety of color schemes will give the separating area of your house. The combination of various patterns and paint make the sideboard look very different. Try to combine with a very attractive so it can provide enormous appeal.
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Related Post "Indian Sideboard Furniture"


text:
LGCT
Italy's historic city of Rome hosts the sixteenth leg of the tour against a beautiful inspirational backdrop, which has been attracting visitors from all over the world for over two millennia.
City GuideCity Guide
WELCOME TO ROME
Beautiful, inspirational Rome has been attracting visitors for over two millennia and continues to be one of the most exhilarating destinations in the world, with the unique Stadio dei Marmi an exceptional setting for top show jumping.
Rome is the capital and largest city in Italy, located in the Lazio region. There has been a human settlement on the site for over two millennia, and Rome is one of the oldest continuously occupied cities in Europe. It was the leading city during the Roman Empire, and there are many amazing places to see - all beautifully preserved - from the Colosseum to the Pantheon. Built along the shores of the Tiber river and home to the smallest country in the world, The Vatican City, it is a place of pilgrimage for people from all over the world.
Rome is also famous for playing a leading role in many key artistic movements such as the Renaissance, Baroque and Neoclassical, many artists made Rome the centre of their activity leaving behind a rich legacy for today's visitors to explore.
This crucial leg of the Longines Global Champions Tour and GCL, is hosted in the unique Stadio dei Marmi, surrounded by 59 classical marble statues depicting different sports. The stadium is one of the arenas in the Foro Italico sports area, home to the Italian Olympic Committee. Every year spectators fill every space available to catch a glimpse of the best in show jumping in action.
Population of Rome
Tourists per year
15 - 27 C
Average temperature during LGCT
GPS Coordinates : 41°56′01.32″N 12°27′28.35″E
Airport Location
FCO Leonardo Da Vinci Airport: 41°48′01″N 12°14′20″E
CIA G.B. Pastine Airport : 41°47′58″N 12°35′50″E
There are several transfer options from the airport including taxi, bus and train.
Getting around in Rome
Many of Rome's key attractions, piazzas and restaurants can be accessed on foot. There is also a Metro, though this is quite limited, as well as buses, taxis, and a tram. For more information visit this link: https://www.rome.net/transportation
There are a huge number of famous and popular tourist attractions in Rome. Here is a selection of a few of the most iconic:
Museo de Roma
Palazzo Braschi
Galleria Borghese and Villa Borghese
See all the action live on GCTV
Make the most of each event with a hospitality package
Explore the world of Global Champions events
Sign up for exclusive news and content
My vision is clear. Only the best for the best.
Jan Tops - Founder & President
Visit LGCT Facebook pageVisit LGCT Twitter pageVisit LGCT Instagram pageVisit LGCT Youtube page
Visit GCL Facebook pageVisit GCL Twitter pageVisit GCL Instagram pageVisit GCL Youtube page
© Global Champions GCL BV 2021


WORCESTER -- Senior Blake Rice (North Branford, CT) accumulated 233 yards and four touchdowns, including two by sophomore Nic Rossi (Freehold, NJ), in a 41-7 WPI win over visiting U.S. Merchant Marine Academy in a NEWMAC Football game Saturday at Alumni Stadium.
The Engineers are now 5-2 on the year and 3-1 in NEWMAC play while the Mariners are 3-4 and 2-3.
Rice connected with Rossi for a 40-yard touchdown midway through the first quarter. Just over two minutes later, Rice connected with junior Erik Fyrer (Ipswich, MA) with an 83-yard reception. Junior Spencer Herrington (Clearfield, PA) converted both PATs and added a field goal four seconds into the second.
Merchant Marine broke up the shutout with a 59-yard pass from senior Brice Moore (Pace, FL) to sophomore Joe Vitelli (Warrington, PA) with 11:08 on the scoreboard. WPI sophomore Stephen Lauro (Suffern, NY) returned the ensuing kickoff 79 yards. Herrington's third extra point of the day made it a 24-7 game heading into the break.
On a Mariner drive late in the second, WPI senior Dereck Pacheco (Barnstable, MA) made three consecutive stops, capped by a seven-yard sack to force a punt.
The guests ran 11 plays for 51 yards; however, junior Luca Cerasani (Abington, MA) recovered a fumble at the 30 yard line in the latter portion of the third. Ten plays and 70 yards later, WPI cashed in on the turnover courtesy of a Rice to senior Corey Coogan (North Kingstown, RI) 34-yard touchdown catch.
After the Engineers punted the ball away, sophomore Nick Ostrowski (Charlton, MA) intercepted the ball on the first play of the USMMA drive. Rossi then added a second score as he hauled in a 22-yard TD score on the initial play of the next series early in the fourth. With less than a minute to play Herrington split the uprights with a 36-yarder for the 41-7 final.
Rice was 12-of-23 passing as senior Eric Cosmopulos (Seekonk, MA) was 3-of-5 late in the game. Field achieved his second 100-plus yard game in three outings with 108. Sophomore Sean McAllen (Prospect, CT) chipped in with rushing yards. Fyrer led the receivers with 89 yards and a score, as well as five kickoffs with an average of 58.8 yards, to go along with Rossi's 65 yards and two TDs.
Ostrowski made a game-high nine stops and nabbed an interception. Junior Sam Malafronte (Abington, MA) tallied eight solo tackles and a sack while Pacheco finished with eight tackles (seven solo) and four for-loss, including a sack. Senior Nabeel Tokatli (Worcester, MA) added a sack, a pass breakup and a quarterback hurry. Senior Aaron Hartford (Norwell, MA) also recorded a tackle for-loss.
Moore completed eight passes for 150 yards and a touchdown, as well as 64 yard on 27 carries to pace the rushers. Vitelli totaled 104 yards on four catches and a score.
Freshman Noah Newburgh (Gilbert, AZ) and junior Trever Huss (Orange City, IA) each made eight tackles for the Mariners. Junior Jake Wallace (Pittsburgh, PA) totaled 2.5 for-loss and a sack. Juniors Brian Harris (Yonkers, NY) and Jacob Davis (East Chatham, NY) each collected a tackle for-loss.
The Engineers led in total offense (420-273), both rushing (162-123) and receiving (258-150) yards, and time of possession (34:48-25:12).
WPI is at MIT Saturday at noon and Merchant Marine is at Catholic in two weeks, also a noon start.


text:
ldrahnik/regexp
======

[![Build Status](https://travis-ci.org/ldrahnik/regexp.svg)](https://travis-ci.org/ldrahnik/regexp)
[![Latest stable](https://img.shields.io/packagist/v/ldrahnik/regexp.svg)](https://packagist.org/packages/ldrahnik/regext)
[![Downloads total](https://img.shields.io/packagist/dt/ldrahnik/regexp.svg?style=flat-square)](https://packagist.org/packages/ldrahnik/regexp)

Set of regular expressions.

Requirements
------------

ldrahnik/regexp requires PHP 5.4 or higher.

- [Nette Framework](https://github.com/nette/nette)

Installation
------------

Install regexp to your project using  [Composer](http://getcomposer.org/):

```sh
$ composer require ldrahnik/regexp
```

Usage
-----

Register extension in config file

```sh
extensions:
	regexp: regexp\DI\RegexpHelperExtension

regexp:
	myRegularName: ^[0-9]{1,10}$
	twitterUsername: foo
```

Now you can use all regulars through services

```php
	/** @var \regexp\Regexp @inject */
	private $regexp;

    public function __construct(regexp\Regexp $regexp)
    {
    	$this->regexp = $regexp;
    }

    public function createComponentForm()
    {
        $form = new Nette\Application\UI\Form();
        $form->addText('twitter', 'Twitter username')
            ->setDefaultValue('@')
            ->addCondition(Form::FILLED)
        	    ->addRule(Form::PATTERN, 'Please enter twitter username, for example: @username',
        	    $this->regexp->getTwitterUsername());
        ...

        //  $this->regexp->getRegularExpression('twitterUsername'));
        //  equivalent of that expression is
        //  $this->regexp->getTwitterUsername();
    }

    ....
```

You are able to use or override already existing embedded regular expressions

```sh
'username' => '^[a-z0-9_-]{3,16}$',
'twitterUsername' =>  '^(\@)?[A-Za-z0-9_]+$',
'password' => '^[a-z0-9_-]{6,18}$',
'facebook' => '^(https?:\/\/)?(www\.)?facebook.com\/[a-zA-Z0-9(\.\?)?]',
'google' => '((http|https):\/\/)?(www[.])?plus\.google\.com\/.?\/?.?\/?([0-9]*)'
```

redpajama_set_name: RedPajamaGithub


China's ''hostile'' environment has created a dispute with the foreign companies that are planning to invest and expand their operations in the nation.
The pessimism on China's failure to open access to foreign investments is a matter in need of careful and urgent ''treatment'' anytime soon.
Based on the chamber's survey report, the challenge that both the European and Chinese companies are currently facing, due to China's slowdown, leads to an intensified pessimistic environment for European business.
Beijing's attempts toward moving in the opposite direction, such as negatively interfering with the internet access, or having further security laws, harms China's international and domestic business activity.
According to a survey, around 47% of the European companies are planning to expand in China, recording a 9% decrease compared to 2015.


text:
Q: localised reviews on the App Store How can i check that the following code opens the chinese version of the App Store?
Is there a localised version of this code, that will drive the user directly to the correct language version of the review page for my app?
[[UIApplication sharedApplication] openURL:[NSURL URLWithString:@"itms-apps://itunes.apple.com/app/id12345678"]];

A: if you add "it" (italy) or "fr" (france) or else in the url address it should work:
https://itunes.apple.com/it/app/id12345678

redpajama_set_name: RedPajamaStackExchange


DPA is a home-grown architectural practice evolving in tandem with the building of nationhood since the independence of Singapore. Founded in 1967 with a deep concern for the built environment and the need to create architecture of excellence, it aims to enrich the human experience and spirit through its planning and architectural works.
Growing from a single office of a dozen to 1,200 strong in fifteen offices worldwide, we have generated many significant projects over more than 40 years of continued operation; yet the process of critical self-renewal remains in our culture as we seek to stay meaningfully relevant to the society we serve. Through a strong commitment to design excellence, we aspire to make our mark on the global stage by making significant contributions to the field of architecture and to the design environment, with the aim to improve the quality of life of the people who enjoy our work.
Conversant with local codes and regulations.
Completed BCA Academy's BIM Modeling and BIM Management would be an added advantage.


The new website launched by the Web Development Group, houses a search-able database of resources, including guides and tools, available to provide assistance to AMECO's audiences as well as a secure "members online" section which is fully integrated with the website.
"We are thrilled to have the opportunity to work with the Association of Missing and Exploited Children's Organization and we ardently support their mission. We look forward to a long and prosperous relationship with them and will continue to provide their staff with consultation on social media techniques, as well as offer new creative ideas to further enhance their site," said Ab Emam, the founder of the Web Development Group.
Give us a ring today to get started on a project.


Last weekend was my first time at Fro Fashion Week, and I am so glad I went. My friend and fellow blogger Ebony from Make Me Over Eb spoke at this event last year. She told me it was a really great event that I should try to go to and see what it is about. Since I've decided to go natural again, and the event was just three hours away I said, "why not?" Well… so far, so good.
All of the women here at Fro Fashion Week Spring 2013 have been so inspirational. We shared our hair journeys, and special hair tips. It was like we were sharing some kind of special hair bonding experience. We laughed and joked and had us a good ole time! I bought a VIP pass, so I received a box full of natural hair goodies that should help me transition from chemically relaxed hair to fluffy and full natural hair. I miss my old hair texture, my natural hair texture, and seeing all of these women with beautiful natural styles is making me impatient for hair growth, but excited for change.
I met a lot of brands that have some very interesting natural hair products. I really can't wait to meet them. I met the brother/sister duo of OBIA Natural Haircare, I met the creative director for Shea Moisture, and I met Youtube guru BlackOnyx77. She is the cofounder of Alikay Naturals hair products, and was a delight to meet. When I met Minista Jazz at the Hair Tease booth, she gave me her daily affirmation. I will be saying, "I am beautiful when I think beautiful thoughts." everyday now. I also met the following brands: Purgasm Shop, Brijor Boutique, Uneshia Salters from The Textured Hair Institute, Mainelement:Love, Curl Collection, and Naptural Passions. I can't wait to try their products. Oh and speaking of Hair Tease and Mainelement:Love again, I had never heard of hair teas before. Both companies sell hair teas though. Apparently you brew them and then wash and condition your hair with them. Who freaking knew?!
I also went to a ton of informational workshops that taught me how to transition to natural with stylist Deshonica Kerrie. I learned about natural hair in the workplace with Jasmine Johnson. I also learned some twisting techniques from BlackOnyx77. The best part was when I went to the Curls Unleashed workshop and was taught how to walk the runway by model Kenya Thomas and met natural hair stylist Key from Key Essentials Hair.
Saturday night was Fro Fashion Week Spring 2013 runway night. I saw a ton of designers and lots of cute hair and makeup looks. Check the gallery to see my picks for the best looks of the night. Watching plus size model, and Fro Fashion Week Spring 2013 cover model, Chisandra Wells walk the runway was a treat and definitely fun! On Sunday, I woke up early and went to Bloggers, Brands, and Brunch. I was so great to meet fellow bloggers and brands and listen to their stories. Youtube guru CharyJay spoke about vlogging. She talked to us about working with brands and what products you should use to make a great eye catching video. She definitely validated a lot of things for me.
Fro Fashion Week Spring 2013 was a lot of fun. I can't believe I missed the other four seasons of the fashion week for natural hair divas. Next season will be the first season outside of Atlanta. I can't wait to see what Tarin Boone, 25 year old founder of NaturallyMe! Media, is bringing in the months to come!
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