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Location: Orlando, FL
Originally Posted by Looney
I recommend stopping Season 5 after OBJECTS AT REST, 5.21. Save 5.22 SLEEPING IN LIGHT until you have watched everything else, all movies CRUSADE, LEGEND OF THE RANGERS, and THE LOST TALES. TRUST ME. You will thank me. It will be VERY difficult. You will want to watch it so bad after you see OBJECTS AT REST, 5.21, but don't give in.
On a first viewing??? Looney, what's the matter with you telling somebody to break up the emotional impact of the final three episodes???? NO NO NO NO!!! I forbid it! On subsequent viewings they can go to the trouble (I'm not really sure why) of doing the chronology route but certainly not the first! Sheesh!!
"You know, I used to think that life was terribly unfair. Then I thought, wouldn't it be much worse if life were fair? If all the terrible things that happen to us come because we actually deserve them? So now I take great comfort in the general hostility and unfairness of the universe." ~~Marcus Cole
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Originally Posted by Jan
On a first viewing??? Looney, what's the matter with you telling somebody to break up the emotional impact of the final three episodes????
I guess if I were going to pinpoint what is the matter with me under these circumstances I would say it is that I am a GENIUS.
(Axionz don't read this spoiler. It is really only meant for Jan.)
Spoiler for spoiler:
Yes there is emotional impact of the end of the series, but then there is emotional impact of the end of the SAGA. I can't think of any SAGA that comes to a better ending than SLEEPING IN LIGHT. And SLEEPING IN LIGHT is soooooooooooo far superior to everything that followed it is the best way to close the novel on a satisfying note.
OOOOOOO now Axionz is going to have to make a decision. Either way is win / win so it isn't much of a choice. The ONLY reason one might slightly lean Jan's direction is that it could take awhile to get access to and watch all the movies, CRUSADE, LEGEND OF THE RANGERS, and THE LOST TALES.
And OBTW Axionz, good luck choosing a viewing order for CRUSADE.
Yes this will now be a tough decision, my original plan was to watch through all of season 5 then check out the movies but now I'm stuck haha!
Btw I just noticed Crusade is an actual spin off series from Babylon 5!? from what I can see a completely different cast, I wonder why it only ran 1 season? Reviews for it are showing as very good as well.
I just watched Season 5 episode 4 A View From The Gallery, the point of view from 2 technicians that dart about the Babylon 5 station doing their job fixing stuff haha, that was actually a fantastic episode!
HA!!!!! SEE TOLDJA EVERYBODY!!!!!
A VIEW FROM THE GALLERY is a very .... ummmm how should I say this.... debated episode. I personally think it is a BRILLIANT concept that has some weakness in the execution. (And truth be told I think all of them are brilliant concepts. ) You will find others out there with a large dislike for A VIEW FROM THE GALLERY. Actually not many I can think of prowling around here, but those other internet places you might get some debate. My "TOLDJA" comment was more directed at the Universe than anyone in particular.
Trust me on this one. You'll be watching the show numerous times after this (well, most people do) and you can play with all sorts of orders then. But for this first time, go with the order it was shown in the first time. Because that's the order that JMS knew we'd see it in and so that's how he was writing for the effect he wanted us to have.
The short version is that TNT resucued the Babylon 5 show when it was cancelled after the network carrying it collapsed. That was an existing show so they left JMS alone to do as he pleased. So Season 5 ran and the reruns were running and, like any TV network, they kept an eye on viewership. Turns out that they found that the core TNT audience would click off when B5 came on and the B5 audience would click off when B5 went off. So no increase in viewership. BUT they'd already contracted for Crusade. After getting those results, they decided to get out of the contract 'by any means necessary' and gave JMS egregious notes for what they wanted him to do with the show (more later after you've seen it). Eventually JMS said NO and so the show was killed halfway into filming the first season, months before it ever aired.
I enjoyed that one a lot. But I usually like the off-format episodes a lot. As Looney says, opinions on this one are split very often. I loved the chemistry between Mac and Bo.
February 10th 21, 08:58 #26
Yeah. I loved A View From The Gallery for the same reasons that I thought And Now For A Word or Intersections In Real Time were brilliant too.
The whole premise of B5 (a single, ongoing story told over the course of 5 years) was something completely new in its day. But the crew weren't going to stop there, "Let's do something different" was the way they approached a lot of things.
Actually I need some clarification here because I'm not sure how those three episodes relate to each other, so I'm not sure why you love them for similar reasons? Is it because you are getting an outsiders view? Just a bit confused on the reasoning here. Also I would throw THE ILLUSION OF TRUTH 4.8 into any conversation where AND NOW FOR A WORD 2.15 gets mentioned, but that is just a personal preference.
Not that anyone does ask me, but if anyone did, I'd recommend And Now For A Word as a good introduction to the series, it gives the viewer a good overview of all the characters, the station, and the circumstances.
It may be sacrilege to say this, but I find Intersections in Real Time a bit dull. I rarely re-watch it.
The Illusion of Truth feels a bit forced to me. Stuff like "Nothing in the Universe can stop us" felt completely unnatural things to say. Though I did appreciate the concept of showing how things can be taken out of context. Nowadays they'd just deep-fake it.
A View From the Gallery... yeah, not my cup of tea, but I understand why people like it.
The other off-format episode I can think of is The Very Long Night of Londo Mollari, which I think is very underrated, but it's one of the best episodes of season 5.
By the way, just want to say how much I'm enjoying reading Axionz thoughts about viewing the show for the first time. There's also been a lot of first-timers posting on Twitter after watching on HBOMax, and it's a joy to read.
Those are episodes that did something different. Either we see things from the point of view of two minor characters, or as a news report rather than as an episode. Or as a single room drama.
Babylon 5 did a lot of things differently from other shows. They liked to play with the idea of what their show even is. Deconstruction of Falling Stars is again another example of something I don't think I've ever seen in any other show (Except for the totally ham-fisted way that Star Trek Enterprise handled it in their final episode).
I totally agree with Jan here. Watch S5 in the intended (airing) order. Don't worry about the films, spins offs, etc for now.
IMHO most of the TV Movies are pretty bad and only In the Beginning really stands up as excellent. They're like a fun little bonus if you find yourself craving more (and you will!)
Crusade is a bit of a curiosity. I've seen it from start to finish three times, and on my third viewing, I came down very heavily on the side that it shouldn't have been made. It just felt cheap and derivative to me, with rare moments of quality. BUT, that's just me. Check it out once you are done with B5 proper. Everything after the original show is diminishing returns, but it's cool there are extra things here and there to watch.
Enjoy the final stretch! Whilst S5 is a bit up and down in terms of quality, it has some superb moments and B5 has one of the best finales.


| ORGANIZE MY DRAWER | Pantry & Kitchen Project — Minne Pristine & Co.
I have had the pleasure of collaborating with Organize My Drawer for the month of August, using their custom drawer inserts!
As a Professional Organizer, I come across many different sized drawers, so I love how I'm able to custom make each insert to fit the drawer space for my client's items. I can choose to use one of their many template offerings, or create a custom design from scratch. Another favorite feature of the design process of mine is making selections from the variety liners offered.
Take an inside look at how I used their product in a two recent projects, a butler's pantry and a kitchen makeover!
My client recently completed a home renovation and I had the pleasure to organize and style their beautifully renovated Butler's Pantry. Nothing like starting with a clean slate!
My client loves to have family and friends over for get togethers, so it was very important to make this space fit their hosting lifestyle. During my consultation, we walked through their day to day use of this space and the direction they wanted their pantry items to flow.
After planning where all the pantry items went, the next step was organizing each drawer and maximizing the space to it's full potential. I was able to do just that by creating the perfect fit organizers using Organize My Drawer.
I took the drawer measurements near the coffee/tea station and created the drawer inserts using their user friendly website. The clear arcylic organizers give the drawers a nice clean look, as well as a reliable material to hold all the drawer items.
I created sections in the top drawer for all the morning go-to's! A few rows designated for the Keurig cups and rows for the variety of tea. The second drawer was designated for additional storage, including all the back stock of coffee/tea and storage for the larger tins.
The second project completed with the Organize My Drawer inserts was in my client's beautiful kitchen! The Organize My Drawer organizers were a great solution to maximize the drawer space in this apartment kitchen.
For this project, I used the clear arcylic organizer for the silverware/bar utensil drawer. I love how the clear inserts give such a crisp look. The second drawer organizer was created to hold all the larger kitchen utensils, measuring cups and other miscellaneous items. I selected the Charcoal Foam Liner for the second drawer, making it easy to spot where all the utensils are.
The final step was placing everything in their new homes. The organizers not only give a Pristine look to my client's kitchen, but more importantly help streamline their daily routines in this space.
I hope you enjoyed the tour of my recent client organization projects! I highly recommend Organize My Drawer for your organizational needs. You can be sure see more of this product in other projects of mine!


Dr. Hugh Lovejoy is an otolaryngologist who specializes in comprehensive adult & pediatric ENT care, balloon sinuplasty, and thyroid surgery in the Charlotte area at our University office. He graduated from the College of Charleston and received his medical degree from the Medical University of South Carolina. His internship was at the North Carolina Baptist Hospital, Bowman Gray School of Medicine. His residency was at the Bowman Gray School of Medicine. He is board-certified by the American Board of Otolaryngology – Head and Neck Surgery. He is a member of the Mecklenburg Medical Society and Alpha Omega Alpha, the medical school honor society.
Dr. Lovejoy practices in our University (2325 West Arbors Drive, Suite 201, Charlotte, NC) office. To make an appointment with him, call 704-295-3000. You can also request an appointment online or through myCEENTAchart.


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Bacillus subtilis è un batterio Gram-positivo, conosciuto anche come bacillo del fieno o dei pascoli, comunemente presente nel suolo.

Descrizione
B. subtilis è a forma di bastoncello, in alcune fasi vitali fortemente flagellato, ed ha la capacità di formare un corpo di protezione duro, una endospora di protezione, permettendo all'organismo di tollerare condizioni ambientali estreme.
A differenza di numerose altre specie note, B. subtilis  è classificato come aerobico obbligato.

Attività e patogenesi
B. subtilis non è un patogeno umano. Esso comunque può degradare o può contaminare gli alimenti, e modificarli, ma raramente causa intossicazione alimentare.

Il Bacillus subtilis produce l'enzima proteolitico subtilisina.
Si ritiene che, per questo, invece collabori alla elaborazione delle fermentazioni tradizionali dei cibi a base di cereali, mais e fagioli, in America, (Pozol ed altre); miglio e sorgo in Africa, riso, fagioli e pesce in Asia.
Tali cibi sono modificati dalla fermentazione, sia nella consistenza che nelle caratteristiche organolettiche, sia anche nel contenuto (proteine pregiate); tali caratteristiche permettono un miglioramento ed un arricchimento sostanziale dei cibi.

Riproduzione
Il B. subtilis si può dividere simmetricamente e generare due cellule figlie (scissione binaria), oppure, in modo asimmetrico produrre una singola endospora che è resistente a fattori ambientali come il caldo, l'arido, l'acido ed il sale.

In tal modo le spore possono persistere nell'ambiente per lunghi periodi di tempo.
Le endospore si formano in condizioni di stress ambientale o nutrizionale, la lunga durata è giustificata dal fatto, possibile, di dover superare il periodo sfavorevole ed il ritorno di condizioni favorevoli.

Nella fase normale vitale favorevole il batterio è di norma lungamente flagellato, cosa che gli permette una ampia mobilità, ma su dimensioni comparabili alla propria dimensione, in fase di "sopravvivenza latente" di spora è completamente immobile, ma è spesso trascinato e diffuso dagli eventi meteorologici (pioggia, vento).
Quindi il batterio alterna le due forme riproduttive in funzione dell'ambiente.

B. subtilis è un organismo modello per studiare la replicazione dei cromosomi batterici.
La replica ha inizio (su un cromosoma circolare) in un singolo locus, detto appunto "origine".
La replica è bidirezionale, in senso orario ed antiorario e si completa al locus finale, opposto all'origine: La regione finale contiene diverse brevi sequenze di DNA (siti Ter) che codificano per l'arresto della replica.

Tutti i passaggi della replicazione sono mediati da proteine specifiche.

Può essere interessante il confronto dell Bacillus subtilis (Gram Positivo) ed il batterio Escherichia coli (Gram negativo).
Le fasi di promozione, inizio e terminazione sono simili, ma le proteine che per alcune fasi sono simili o uguali, in altre sono diverse, pur svolgendo sostanzialmente compiti analoghi.

Questo permette di fare interessanti paragoni sulle strategie evolutive di organismi simili che hanno elaborato complessi proteici diversi, ma pur sempre perfettamente attivi, ed adatti, per la replicazione corretta dei propri genomi.

Utilizzo come organismo modello
B. subtilis è dimostrato notevolmente suscettibile di manipolazione genetica, questo unito al fatto della sua sostanziale non pericolosità, è stato ampiamente adottato come organismo modello per studi di laboratorio, in particolare sui comportamenti di sporulazione, che è una via semplificata per seguire la differenziazione cellulare.

In termine di "popolarità" come organismo modello di laboratorio, B. subtilis è spesso utilizzato come l'equivalente Gram-positivo dellEscherichia coli, un batterio ampiamente studiato Gram-negativo.B. subtilis è inoltre utilizzato in meccanica dei fluidi negli studi di microfluidità: assieme all'''Escherichia coli  è il principale esempio di nuotatore "pusher", ossia quel tipo di microorganismi che, per nuotare, esercitano una spinta sul fluido.

 Usi
B. subtilis è utilizzato come inoculante nel suolo in orticoltura e agricoltura.
B. globigii, una specie simile, ma filogeneticamente distinta, è stato usato come un simulatore di diffusione batterica tracciabile (innocua) in una simulazione di guerra biologica durante il progetto SHAD (detto Progetto 112).

Enzimi prodotti da B. subtilis e B. licheniformis sono ampiamente utilizzati come additivi ad attività biologica pulente in ammollo nei detersivi per bucato.

Altri usi includono:
Un ceppo di B. subtilis in precedenza noto come il Bacillus natto' è utilizzato nella produzione commerciale del nattō, un cibo giapponese, così come lo cheonggukjang, analogo cibo coreano.

Una notevole gamma di cibi fermentati si ritengono ottenuti anche per l'attività proteolitica ed enzimatica del Bacillus subtilis.B. subtilis ceppo QST 713 (commercializzato come QST 713 o Serenade) ha un'attività fungicida naturale, ed è impiegato come agente di controllo biologico.

È stato popolare in tutto il mondo prima dell'introduzione degli antibiotici come vaccino subtilico ovvero come agente immunostimolante per aiutare il trattamento delle malattie del tratto gastrointestinale e urinario. È ancora ampiamente utilizzato in Europa occidentale ed in Medio Oriente come una medicina alternativa.

Può convertire (decomporre) alcuni esplosivi in composti innocui di azoto, anidride carbonica e acqua.

Le sue proprietà di superficie vincolante ed avvolgente sono state proposte per svolgere un ruolo nel contenimento di rifiuti contenenti radionuclidi (torio, plutonio), migliorandone le possibilità di cattura e smaltimento.

Ceppi ricombinanti pBE2C1 pBE2C1AB sono stati utilizzati nella produzione di poliidrossialcanoati (PHA), in tal modo rifiuti di malto possono essere utilizzati come fonte di carbonio per la produzione a basso costo PHA.

È utilizzato per produrre amilasi.
È utilizzato per la produzione di acido ialuronico. utile al settore farmacologico, connesso al sanitario.

GenomaB. subtilis ha circa 4.100 geni. Di questi, solo 192 hanno dimostrato di essere indispensabili, altri 79 sono stati considerati come essenziali, o fortemente determinanti.
La stragrande maggioranza dei geni essenziali sono stati classificati in relativamente pochi domini del metabolismo cellulare, circa la metà sarebbero coinvolti nella elaborazione delle informazioni, un quinto coinvolto nella sintesi dell'involucro cellulare e la determinazione della forma e divisione cellulare, e un decimo collegato alla energetica cellulare.

Sono stati caratterizzati diversi RNA di codificazione sconosciuta o incerta.

Utilizzi medici

Nel 1835, il batterio è stato originariamente chiamato Vibrio subtilis da Christian Gottfried Ehrenberg, e ribattezzato da Ferdinando Cohn Bacillus subtilis nel 1872.

Colture di B. subtilis'' sono state utilizzate fino a tutto il 1950 come una medicina alternativa a causa degli effetti immunostimolanti della sua parete cellulare, funzione preziosa in assenza di antibiotici.
Si è notato infatti che la reazione immunitaria di digestione di frammenti della sua parete cellulare produceva un significativo aumento di attività immunitaria ad ampio spettro, compresa l'attivazione di specifici anticorpi IgM, IgG e IgA, ed il rilascio di dinucleotidi CpG.
È inoltre importante la sua capacità di indurre attività di produzione di leucociti e citochine, importanti per lo sviluppo di citotossicità verso le cellule tumorali.

È stato commercializzato in tutta l'America e l'Europa dal 1946 come aiuto immunostimolante nel trattamento delle malattie dell'intestino e del tratto urinario, quali Rotavirus e Shigella, ma ha visto una drastica riduzione di popolarità dopo l'introduzione del antibiotici a basso prezzo, nonostante producano un basso livello di reazione allergica, e con livelli di tossicità significativamente inferiori agli antibiotici per la flora intestinale normale.

Note

Altri progetti

Collegamenti esterni

Bacillus
Organismi modello

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Body Weight & Performance: What if before class your coach randomly distributed 25# weight vests to 1/3 of the class? Would it be unfair to those who received a vest? The answer is a huge yes. How much excess weight are you lugging around in your workout and everyday life. It would be my guess that our average member is holding 20-25 pounds of extra weight. Whether you are over or under that number every pound of extra weight your body holds puts you at a disadvantage. Eat meat and veggies, nuts and seeds, and some fruit. Avoid sugar and starchy foods at all costs. Your joints and workout times will thank you!


The number of people suffering from some form of inflammatory disease in the UK is currently unnervingly high. Recent statistics show that in the UK alone 150,000 people suffer from Chronic Fatigue Syndrome, 1 in 1,500 suffer from Crohn's disease, 2.5 million have some form of cardiovascular disease, and 9 million are affected by arthritis – and these are just to name a few. Experts have linked the high numbers of inflammatory conditions such as arthritis, asthma and irritable bowel disease to certain factors of Western diet and lifestyle.
Current medical interest in omega-3 fatty acids also stems from observations of the different prevalence of some chronic diseases in the Greenland (Eskimo) population in which inflammatory diseases are significantly less common, relative to Western populations. In comparison, increased nutritional intake of marine fish, providing increased supply of omega-3 fatty acids, was highlighted as the main factor responsible for such differences here. Fish oils are the most abundant source of long-chain omega-3 PUFAs (polyunsaturated fats) such as eicosapentaenoic acid (EPA).
Changes in food processing methods, diet and lifestyle over the past century have dramatically decreased our intake of omega-3, and increased our intake of short-chain omega-6 (mainly in the form of vegetable oils, which should be replaced with olive oil). According to scientists it is absolutely vital to have the correct balance; a significant excess of one type over the other can have a detrimental impact upon health. The ideal ratio of omega-6 to omega-3 being in the region of 2:1, the average diet is now quite significantly out of balance at an average of approximately 25:1. Indeed leading medical researcher and fatty acid specialist, Professor Puri of Hammersmith Hospital, London, suggests that deficiencies in omega-3 fatty acids may be responsible for increases in the rates of inflammatory disorders.
The means by which omega-3s exert their anti-inflammatory actions is somewhat complex, but nevertheless extremely effective. After consumption, omega-3 PUFAs can be incorporated into cell membranes and reduce the amount of arachidonic acid (omega-6) available for the synthesis of proinflammatory eicosanoids such as prostaglandins and leukotrienes, thereby providing an obstacle to the production of inflammatory agents. The potent anti-inflammatory EPA (eicosapentaenoic acid) specifically encourages the omega-6 pathway to produce anti-inflammatory prostaglandins, making purified supplements such as Vegepa and OmegaForce suitable for people trying to combat inflammatory problems.
A recent review of the research relating to the therapeutic benefits of omega-3s reports considerable research into numerous conditions, including arthritis, coronary artery disease, inflammatory bowel disease, asthma and sepsis, all of which have inflammation as a key component of their pathology. Many of these placebo-controlled clinical trials of fish oil in chronic inflammatory diseases reveal significant benefits, including decreased disease activity and a lowered use of NSAIDs (non-steroidal anti-inflammatory drugs), which although give short-term relief to sufferers, come with a host of serious side effects long-term, including gastrointestinal and cardiovascular complications.


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Home > North Korea > article
Confusion over reported trip by top N. Korean official in China: Yonhap
Lim Chang-won Reporter(cwlim34@ajunews.com) | Posted : March 27, 2018, 18:25 | Updated : March 27, 2018, 18:25
웨이보
[Yonhap News Photo]
SEOUL -- The South Korean government has been striving Tuesday to verify news reports that a high-ranking North Korean official, possibly leader Kim Jong-un, is visiting China.
The arrival of a special North Korean train in Beijing was reported on Monday. "Our government is trying to thoroughly grasp the related situation, including whether the reports are true," a foreign ministry official said. "(But) whether Workers' Party of Korea Chairman Kim Jong-un is visiting China has not been verified."
Another ministry official also said details of the train's arrival were not known. "The Chinese side does not appear to have provided related details."
One government source suggested that it might not be the chairman who is visiting China, saying, "There is not enough circumstantial evidence to indicate that Kim Jong-un is visiting China ... although the possibility cannot be ruled out."
Other officials added that regardless of whether Kim is indeed in China, it is a good sign that could add to the growing reconciliatory mood with North Korea. "North Korea could reach out to China and Russia in addition to South Korea and the United States from the perspective of foreign relations," one of them said.'
North Korea's state media, including the Rodong Sinmun newspaper and the Korean Central News Agency, have not published any reports on the move so far. North Korean news media has a history of publishing its former leader's China visits but only after he nearly finished his trips, probably because of security reasons.
When the late North Korean leader, Kim Jong-il, paid an informal visit to China in 2011, his travel was published by North Korean news outlets while he was on his way back to North Korea after finishing the seven-day trip.
China's foreign ministry also declined to confirm the trip. Asked by Yonhap News to confirm whether Kim or other high-ranking North Korean officials, such as the leader's sister Yo-jong or nominal state head Kim Yong-nam, who represents the assembly, are visiting the country, the Chinese ministry said, "There is nothing we are aware of."
Foreign Ministry spokesman Noh Kyu-duk in Seoul also declined to verify the move, saying only that, "Seen from the past record, the Chinese government has a precedent of officially announcing human exchanges like this at a (later) time when it is deemed appropriate."
(Yonhap)
Lim Chang-won Reporter
email : cwlim34@ajunews.com
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