text:
Q: returning back to main activity from SettingActivity I got SettingActivity from AndroidStudio Gallery, which uses ActionBar. Everything is fine when I click back button from ActionBar inside SettingsActivity. But when I want to return to main activity using this button in ActionBar nothing happens.
My SettingsActivity uses headers for preferences, so I thought I can check whether I am "inside" any of these headers, and if answer is none then I am in main setting screen and I can call main activity using startActivity(this,MainActivity.class). But problem is I cann't determine whether I am in start screen or in some header. Of course if there are more easy ways to do it I would appreciate it very much.

A: to make action bar back press return back , you have to do it in menu item selected
@Override
public boolean onOptionsItemSelected(MenuItem menuItem) {
    switch (menuItem.getItemId()) {
    case android.R.id.home:
        Intent homeIntent = new Intent(this, HomeActivity.class);
        homeIntent.addFlags(Intent.FLAG_ACTIVITY_CLEAR_TOP);
        startActivity(homeIntent);
    }
    return (super.onOptionsItemSelected(menuItem));
}

redpajama_set_name: RedPajamaStackExchange


With a monthly average of 120 million unique visitors in Q4 2013* there is no denying Yelp's popularity.
Disregarding the importance of customer reviews in today's digital world is a grave mistake. While positive reviews can help improve sales, negative reviews can just as easily make businesses profits take a nosedive so monitoring your businesses reviews is crucial.
Starting in early June, Yelp will allow users to upload videos when they review a restaurant or business. Uploaded videos are restricted to 3-12 seconds, and users have the option to add a cover photo as well as a caption. Videos will be filtered using the same system that photos are filtered with.
As more videos get added, the ones voted most helpful will sit atop of all others in the gallery. The company says they are the feature because it will help users of the service to get a better idea of what the mood and experience of a restaurant or business is really like.
The service will only be available to Yelp's "Elite users" at first but will eventually be made available to the rest of Yelp users.
*note: The statistic and picture were both taken from businessinsider.com.


Nn70.htm+ n70 70 .-Nn70.htm+ n77 77 .
↑ ୧.୦ ୧.୧ ୧.୨ ୧.୩ ୧.୪ ୧.୫ ୧.୬ ୧.୭ Mitchell, C; Prabhu, M (December 2013). "Pelvic inflammatory disease: current concepts in pathogenesis, diagnosis and treatment". Infectious disease clinics of North America. 27 (4): 793–809. PMID 24275271.
↑ ୨.୦ ୨.୧ "Pelvic Inflammatory Disease (PID) Clinical Manifestations and Sequelae". cdc.gov. October 2014. Retrieved 21 February 2015.
↑ Chang, A. H.; Parsonnet, J. (2010). "Role of Bacteria in Oncogenesis". Clinical Microbiology Reviews. 23 (4): 837–857. doi:10.1128/CMR.00012-10. ISSN 0893-8512.
↑ Chan, Philip J.; Seraj, Ibrahim M.; Kalugdan, Theresa H.; King, Alan (1996). "Prevalence of Mycoplasma Conserved DNA in Malignant Ovarian Cancer Detected Using Sensitive PCR–ELISA". Gynecologic Oncology. 63 (2): 258–260. doi:10.1006/gyno.1996.0316. ISSN 0090-8258.
↑ ୫.୦ ୫.୧ World Health Organization (2012). "Global incidence and prevalence of selected curable sexually transmitted infections - 2008" (PDF). who.int. pp. 2, 19. Retrieved 22 February 2015.
↑ "Pelvic Inflammatory Disease (PID) Patient Counseling and Education". cdc.gov. October 2014. Retrieved 21 February 2015.
↑ ୭.୦ ୭.୧ "Pelvic Inflammatory Disease (PID) Partner Management and Public Health Measures". cdc.gov. October 2014. Retrieved 21 February 2015.
↑ "2010 STD Treatment Guidelines Pelvic Inflammatory Disease". cdc.gov. August 15, 2014. Retrieved 22 February 2015.
↑ ୯.୦ ୯.୧ Eschenbach, D (2008). "Acute Pelvic Inflammatory Disease". Glob. libr. women's med. doi:10.3843/GLOWM.10029. ISSN 1756-2228.
↑ "Self-Study STD Modules for Clinicians - Pelvic Inflammatory Disease (PID) Next Centers for Disease Control and Prevention Your Online Source for Credible Health Information CDC Home Footer Separator Rectangle Epidemiology". cdc.gov. October 2014. Retrieved 21 February 2015.


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Feeling for Others (1)
"Weep with those who weep." Ro 12:15 NKJV
In 1883, poet Ella Wheeler Wilcox was traveling by train to an inaugural ball when she noticed a woman weeping across the aisle. Wilcox spent the rest of the journey comforting her, and when she reached her destination she was in no mood to celebrate. Later, remembering the woman on the train, she wrote the opening lines to her famous poem "Solitude": "Laugh, and the world laughs with you; weep, and you weep alone." Holly Vicente Robaina says: "We laugh…play…and celebrate together. Why's it so difficult to cry together?…When friends hurt, Christians say, 'I'll pray for you'…In some cases God heals and restores, but sometimes there's no miracle…only profound sadness. C. S. Lewis wrote about losing his wife: 'Where's God?…Go to him when your need is desperate and what do you find? A door slammed in your face, and a sound of bolting and double-bolting on the inside.' I don't think Lewis would have been comforted by, 'God loves you…I'll pray for you.' While it's great to exhort…we need to evaluate our words before we speak. Are we using 'encouragement' to ignore somebody's pain because we don't want to deal with it? Do we mean what we say, or are we just rattling off polite clichés? Do we expect our words to fix everything? Are we acting like we can do a better job than 'the Comforter'? When we promise to pray for somebody, do we check on them later?…Ever wonder why Jesus wept at Lazarus' tomb? He could just have [told] the mourners, 'Everything's okay folks. God loves you,' and raised Lazarus. Instead He showed His love by crying with them."
Today God is with you
Live for what matters!
You're commanded to love
"Choice morsels"
Are you successful but unfulfilled?
Dealing with fear (7)
My New Career
Fasting about 22 hours ago
Daily Fasting Video - Day 12
21 Day Fast about 22 hours ago
21 Day Fast 2 days ago
Pay off in full
Fasting 2 days ago
Lynda's Career

redpajama_set_name: RedPajamaCommonCrawl


The expansion plan of Mercadona For the Spanish territory leaves behind a lot of job offers, all of them collected in your portal. The chain advertises a total of 460 jobs throughout the national territory to cover vacancies in positions of responsibility as staff of centers throughout the country.
Among them, and as the newspaper points out ABC, the chain seeks personnel with a minimum qualification of professional training (FP) or Compulsory Secondary Education (ESO) to cover 245 jobs with an initial salary of 1,328 euros per month. These positions would be linked to a wage progression in the fourth year to 1,797 in fourteen payments. In total, up to 25,158 euros per year for base positions.
Mercadona returned in 2018 to increase its profits, and also spectacularly. If in 2017 it had reduced its profits due to the heavy investments to remodel the network of stores, last year they recovered their growth and reached a gross figure of 1,213 million euros. Juan Roig, president of the brand, has stressed that the net profit was 593 million, 84% more than in the previous year.
Roig justified the great increase in benefits in that "we have known how to treat customers well. Last year was a big change and that has been noticed. " The firm, with a staff of 85,800 employees, invoiced 24,305 million euros, 6% more. These figures confirm the good health of the Valencian company, which invested more than 1,500 million of its own resources.


Insects are responsible for the most important qualitative and quantitative losses of stored cereals. Significant attacks can cause temperature and humidity to increase, also causing the possibility of fungal attack (with mycotoxin production). Many foodstuff processors and exporters require absolutely insect-free cereals in order to be able to be put on sale or used for processing and/or seed production.
The stored foodstuffs are easy targets for tiny pests, usually Coleoptera, but also Lepidoptera and Diptera. These insects are often already present in the storage environment before the arrival of the raw material, in other cases they may come directly with the already colonised raw material or enter subsequently through the openings in the warehouse. They can often be detriticola species that can cause serious damage to grain, both quantitative and qualitative.
Through trade, the risk of spreading pests has become overt, so much so as to impose strict incoming inspections of the raw material before storage. It is also true that, currently, many pests are now ubiquitous, so a seasonal control plan is to be considered mandatory. The favourable microclimate in storage environments and the speed of insect development contribute to bringing about a rapid and widespread attack on the foodstuffs that can, in a short time, spread to products already packed and ready to be sold.
Among the harmful Coleoptera are the Palm Weevil (Sitophilus spp.), the Lesser Grain Borer (Rhyzopertha dominica), the Sawtoothed Grain Beetle (Oryzaephilus surinamensis) and the various Anobiids (bread and tobacco weevil). These insects directly attack the kernel or the packaging and can be found in warehouses, pasta factories and rice mills. With reference to the order of Lepidoptera, the flying at dusk of butterflies commonly called Moths is frequent.


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Arbor Green on "Margaret," Musical Parents, and the Last Gig of 2020
by Jordan Drazen January 21, 2021
The brainchild of Ali Begg, Arbor Green was formed with the intention of creating songs whose sound is reminiscent of alternative indie and folk bands from North America. Of course, the band's sound also invokes images of their native lands of Edinburgh and Glasgow. Their new single, "Margaret," is no exception. As soon as the track begins, the image of the countryside settles into your head. A soft whirr of ethereal sounds drones in the background as a relaxed electric guitar accompanies Begg's strong vocals. The song takes the listener on a ride, recounting stories of a relationship from the past. As time goes on, the instruments continue to build, filling out the sound of the song. While everything keeps a steady pace, there is a break for an instrumental interlude, which allows the song to breathe even further. Within just five minutes, the song seems to accomplish everything that it set out to. A beautiful blend of indie and folk artists, Arbor Green's "Margaret" is worth a listen.
What was the inspiration behind your name, Arbor Green?
A few years back I used to play under the name Ali Begg & the Evergreen, but that "Something and the Somethings" format was already pretty tired when I started using it. I never ended up releasing anything under that name, but I liked what it evoked for me. I often think I'm at my happiest among trees. Back in 2019 I was listening to an obscure Okkervil River track called "The Surgeon Above the Arbor," and I was playing with the sound of the last word. I recalled that it was also the Latin word for 'tree', and I tacked the word Green onto it to echo the old band name. It doesn't really "mean" anything but I love forest green colours and wear them often, so I guess if nothing else the name translates as 'Tree Green" which is more or less the name of my favourite colour. People seem to confuse it for my given name sometimes, which I enjoy.
How has your upbringing/location inspired your sound?
I was brought up in the Scottish West Highlands by parents who were both musical and had really diverse taste. The earliest gigs I went to were some of the finest traditional musicians in the country, most of whom were local to the area and playing right down the road. As a kid I'd sit in the corner of the village pub drinking pineapple juice while trad sessions went on around me. I sang Gaelic songs in competitions all the way through school. My love for that music has always stayed with me. There's a very real honesty in Scottish traditional music that I aspire to emulate.
I picked up the guitar at age 7. My teacher, a wonderful songwriter called Jim Hunter, quickly got me hooked on the lyrics of the likes of Joni Mitchell, Simon and Garfunkel and James Taylor. My parents' record collection meant that I had already been thoroughly indoctrinated into the music of the Grateful Dead & The Allman Brothers, and my appetite for great songwriting and trippy alt-country sounds grew from there. I still count Mitchell and Robert Hunter among my favourite lyricists. I think if I can point towards the roots of the music I write now, it's probably somewhere in that mixture: traditional fiddle tunes, Gaelic songs and the Grateful Dead!
Which musical artists do you listen to the most?
These days my taste in music is really broad but if I keep this answer to stuff vaguely adjacent to my own music then I always come back to Okkervil River, Bright Eyes, Big Thief and The National. I'm an enormous fan of Lucy Dacus — I think she's phenomenal. Phoebe Bridgers too. And I also think anything Justin Vernon touches turns to gold (though that's not exactly a hot take). In the UK, I've recently really enjoyed work from Alabaster DePlume, Yard Act, Lizzy Reid, Andrew Wasylyk, Scarlett Randle, Mellah, Lemon Drink, MEMES, Casual Drag…heaps of stuff!
Why, in your opinion, was "Margaret" chosen as the first single off your upcoming album?
"Margaret" really isn't a traditional first single. It's nearly six minutes long and it takes two of those minutes before it reaches a chorus. But it's one of the earliest songs I wrote for the record, and it sort of straddles the tones and moods of the rest of the album (it's also the album opener). It's mellow but it has fierce moments. It's got these glassy indie electric guitars but this folk country warmth thing going on too. I wrote it for my grandmother, who passed away when I was maybe 19, so in terms of the grief I'm processing in that song it's the earliest grief addressed on the record. All of this made it feel right for the first release. The album goes to a lot of places, musically and thematically, and this song is probably the closest thing to a roadmap for what's to come.
I saw that you played one gig before the lockdown towards the beginning of 2020, how was it and did you have any idea it'd be your last for a while? Where would you like to play your first gig post-lockdown?
Yeah, our one gig of 2020! It was at a great wee night in Glasgow called Dukebox run by our friend Robbie, who has an amazing band called Ginger (everyone should check out their debut, Gardens). It was maybe a week before things started getting really serious with the pandemic in the UK and I think there was definitely a bit of a feeling that it was going to be the last hurrah for a while. We were sitting around catching up with friends who'd just had all their freelance work cancelled for the next six months or whatever, and I was keenly aware that I might not see most of those people again for a long time. It was a fun night if a bit bittersweet in hindsight. I'd been waiting a long time to play these songs live and it was meant to be the first of many! I don't think there's anything I've missed more than live music since COVID-19 descended on us.
What do you hope to get out of 2021, as far as your music/band goes?
2021 didn't get off to a smooth start for the planet so I'm not counting on anything but I think we're daring to be hopeful. We have a busy release schedule of singles leading up to the album coming out in the summer, and there's lots of work happening around all of that. If fates and vaccines align we'd love to support it with some gigs, but honestly I just want to get that record out there. I've been bowled over by the lovely and positive response to "Margaret" and I'm really excited to have more coming soon. I've also got reams of new material to start properly sorting through, but I think any serious recording will have to wait until the autumn. Life feels very busy, in a good way, and for that I am thankful.
Jordan Drazen
Jordan is a writer obsessed with all things pop culture. From music to movies, he spends most of his time consuming and analyzing others' writing. There isn't a medium which he doesn't enjoy writing for.
SubmitHub Review: Is It Worth It?
Carly Opacic's "Luna": Shimmering Art Pop


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Support Professor TG Teoh
Prematurity is the leading cause of death for the under-fives, with one million children dying every year from preterm birth complications. Preterm birth is a major health challenge globally, yet its causes are complex and not fully understood. Why do some mothers go into labour early? Why are more babies being born preterm? How can we reduce the number of premature births in the UK and worldwide?
Imperial has been at the forefront of pregnancy research for over 30 years. Led by Professors Phil Bennett and TG Teoh, the Preterm Birth Research Group directly involves over 30 clinical doctors and scientists at all levels, from PhD student to senior clinical academics, working closely together to solve this critical problem.
The group is researching the processes at work in the onset of labour, in order to pinpoint the factors that increase the risk of premature birth and to develop new tools that doctors can use to identify women who are more likely to enter labour prematurely. In doing so, they are working to bring better health to infants all around the world, and give them and their families the best chance for long and happy lives together.
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Published online January 1, 2008.
Dr. Seppo Ylä-Herttuala, Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.
Objectives The purpose of this study was to test the feasibility of contrast pulse sequence (CPS) ultrasound imaging for high-resolution perfusion imaging after gene transfer (GT) for therapeutic angiogenesis.
Background Imaging modalities capable of accurate and feasible perfusion measurement are essential for the preclinical and clinical development of therapeutic angiogenesis. However, current methods suffer from compromises between spatial and temporal resolution and sensitivity. Contrast pulse sequence ultrasound is a recently developed real-time perfusion imaging method that generates high-contrast agent-to-tissue specificity and spatial resolution.
Methods Contrast pulse sequence ultrasound was used to noninvasively assess parameters of blood flow 6 days after adenoviral vascular endothelial growth factor (AdVEGF) GT in rabbit and mouse hind limbs with bolus intravenous injection of a microbubble contrast medium. Blood volume, mean transit time, perfusion, and time to the arrival of the contrast bolus were calculated with the gamma variate function. Contrast-enhanced power Doppler ultrasound (CEU), dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and histological capillary measurements were used as reference methods.
Results Blood volume and perfusion increased over 40- and 20-fold, respectively, 6 days after AdVEGF GT in rabbit skeletal muscles. Perfusion values measured with CPS correlated well with those obtained with CEU (r = 0.975) and DCE-MRI (r = 0.854). However, CPS provided superior spatial and temporal resolution showing blood flow in vessels of only 10 to 20 μm in diameter. Contrast pulse sequence ultrasound was also feasible for imaging of therapeutic angiogenesis in mouse hind limbs both at the arterial and capillary levels. The CPS ultrasound revealed that AdVEGF mainly induces angiogenesis in adipose tissue rather than in the skeletal muscle of mouse hind limbs.
Conclusions Contrast pulse sequence ultrasound is an efficient and accurate noninvasive real-time perfusion imaging modality in small laboratory animals and also offers a means for the assessment of muscle perfusion in future clinical trials of therapeutic angiogenesis.
Angiogenesis remains an unfulfilled promise in coronary artery disease. Lack of an easy method to measure perfusion changes after angiogenic therapy has also been a major impediment. Contrast pulse sequence (CPS) is an ultrasound technique that processes non-linear signals in the fundamental frequency. CPS is more sensitive and specific for contrast agents than 2nd/3rd harmonic imaging, and has greater spatial resolution and better tissue subtraction than most ultrasound techniques. The authors evaluated CPS perfusion imaging after adenoviral vascular endothelial growth factor gene transfer and found that it provided superior spatial and temporal resolution (showing flow in 10-20μm vessels) in rabbit and mouse hind limbs. Real time perfusion with CPS correlated well with contrast enhanced power Doppler and dynamic contrast enhanced magnetic resonance imaging. Histology provided corroboration for the results with CPS. Further work will clarify the role of CPS in assessing tissue perfusion in future clinical trials that utilize angiogenic therapies.
Gene therapy for therapeutic angiogenesis is a potential new approach to alleviate tissue ischemia, but so far, promising animal experiments have not resulted in clinical success (1,2). Novel imaging methods capable of measuring blood flow noninvasively and reliably at the capillary level are clearly needed for the development of better angiogenic gene therapy approaches. The current imaging techniques, such as contrast-enhanced power Doppler ultrasound (CEU) and harmonic ultrasound imaging, laser Doppler and optical imaging methods, magnetic resonance imaging (MRI), computed tomography (CT), single-photon emission computed tomography (SPECT), and positron emission tomography (PET), are hampered by compromises between the spatial and temporal resolution, penetration, and sensitivity; might be unsuitable for small animals; or might not be used for imaging of angiogenic and leaky vessels, owing to small-sized contrast media particles (3). Moreover, MRI and PET in particular are less available and require a high level of expertise.
Contrast pulse sequencing (CPS) is a recently introduced contrast-enhanced ultrasound imaging technology that uses nonlinear fundamental frequencies, resulting in improved spatial resolution and higher sensitivity to microbubble contrast media (4). Furthermore, CPS provides better tissue penetration, less attenuation, and more improved tissue subtraction than previous ultrasound perfusion imaging techniques (4). In this study, we used CPS imaging to assess angiogenesis and subsequent perfusion increases in rabbit and mouse skeletal muscle after adenoviral (Ad) gene transfer (GT) of vascular endothelial growth factor (VEGF). Our findings show that CPS is feasible and accurate in small laboratory animals, reaching the level of microcirculation, and is attractive also for clinical studies of therapeutic angiogenesis.
Adenoviral VEGF165 (AdVEGF-A, n = 9) or adenoviral beta-galactosidase (AdLacZ, n = 10) intramuscular GT was performed in the right semimembranosus muscle of New Zealand white rabbit hind limbs (5 × 0.1 ml, titer 1011 viral particles [vp]/ml) as previously described (5,6). In C57Bl/6Ja mice, AdVEGF (n = 6) or AdLacZ (n = 6) GT was done in the adductor compartment of the thigh and in the posterior calf (both 50 μl, titer 1011 vp/ml). All animal experiments were approved by the Experimental Animal Committee, University of Kuopio.
The Acuson Sequoia 512 system and 15L8 transducer (Siemens, Malvern, Pennsylvania) were used for ultrasound imaging. Power Doppler CEU with the bolus injection technique has been previously validated in skeletal muscle perfusion measurement both in animals and humans (6–8). First, CEU (power Doppler mode at 8.5 MHz, mechanical index = 0.60, dynamic range = 10 dB, power = −18 dB, Doppler gain = 40) was performed in rabbits with a 0.3-ml bolus administration of SonoVue (Bracco, Milan, Italy) via the ear vein as previously described in detail (6). There was no blooming of contrast medium with the mechanical index used. In mice, power Doppler imaging was performed without contrast administration (power Doppler at 14 MHz, dynamic range = 20 dB, power = −5 dB, Doppler gain = 50). Cadence CPS imaging was performed in rabbits after an intravenous (IV) bolus injection of 0.5 ml SonoVue at 8.0 MHz (dynamic range = 75 dB, power = −16 dB, CPS gain = −10, T1/0/1/4, Δ4, mechanical index = 0.31). In mice, 50 μl of SonoVue was injected as an IV bolus via a cannula placed in the external jugular vein, and CPS was performed at 14 MHz (dynamic range = 80 dB, power = −8 dB, CPS gain = −15, S1/0/2/4, Δ4, mechanical index = 0.25). The contralateral intact limb was used as an internal control to exclude the effect of cardiac output.
The power Doppler and CPS signal intensities (dB) of video clips were quantified with Datapro (version 2.13, Noesis, Courtaboeuf, France), and signal intensity–time curves were generated. After a bolus injection of a contrast medium, the gamma-variate function (Fig. 1) models the first-pass kinetics of the contrast medium in the region of interest (ROI), which allows the calculation of blood flow (and perfusion) via the determination of blood volume (area under the curve) and the mean transit time (MTT) (8–10). The peak signal intensity of the curve is the maximal contrast enhancement in the ROI representing a simpler estimate of blood flow/perfusion (6,11,12). The time from bolus injection to the arrival of contrast agent in ROI can also be determined, which reflects peripheral resistance (6). PowerShowCase (version 4.95, Trillium Technology, Ann Arbor, Michigan), Camtasia Studio (version 2.0, TechSmith, Okemos, Michigan), and WinAVI Video Converter (version 7.7, ZJMedia Digital Technology) (13) were used for the processing of ultrasound video files for publication in the Windows Media Video 9 format (Microsoft, Redmond, Washington).
The gamma variate function was used to model the first-pass kinetics of the contrast agent and to calculate blood flow ratios (i.e., perfusion ratios if tissue volume is equal) between transduced and contralateral intact limbs. The area under the curve represents blood volume in the region of interest. Blood flow is blood volume divided by the mean transit time (MTT) of the contrast agent. Alternatively, we found that a very good estimate of blood flow (perfusion) can be achieved with the ratio of peak signal intensities between the hind limbs (see Fig. 4). Times to arrival as well as MTT give important information on the structure of the vasculature (see Fig. 4). Ad = adenovirus; AdLacZ = adenoviral beta-galactosidase; CPS = contrast pulse sequence; VEGF = vascular endothelial growth factor.
Perfusion and blood volume measurement with MRI.
The MRI of rabbit thighs was carried out in a 4.7-T magnet (Magnex, Abington, United Kingdom) interfaced to a Varian UNITYINOVA (Varian, Palo Alto, California) console with actively shielded gradients and with an in-house-built surface coil (diameter 38 mm) as previously described (6). Briefly, dynamic contrast-enhanced (DCE)-MRI of perfusion with a FLASH pulse sequence (repetition time = 9 ms, echo time = 5 ms, field of view = 6 × 6 cm2, resolution = 64 × 64, slice thickness = 5 mm, number of averages = 1, acquisition time 0.58 s/image) was done after an IV 0.7-ml bolus injection of superparamagnetic iron oxide particles (Resovist, Schering, Berlin, Germany; mean size 62 nm). The signal intensity–time curves were derived from the DCE-MRI data, and perfusion ratios were calculated as previously reported (6). To obtain high-quality images of blood volume, T2*-weighted gradient echo images (repetition time = 2 s, echo time = 18 ms, field of view = 6 × 6 cm2, resolution = 256 × 128, slice thickness = 2.5 mm, and number of averages = 2) were acquired before and 6 min after the bolus contrast agent injection to determine the steady-state distribution of the IV contrast agent. Blood volume-MRI maps (ΔR2*) were reconstructed as described (6).
After MRI, the rabbits were euthanized, perfusion-fixed, and the muscle samples were processed as previously described (5,6). Endothelium was immunostained with a monoclonal antibody against CD31 (dilution 1:50, DAKO, Glostrup, Denmark) in rabbits and with biotinylated Griffonia Simplicifolia lectin I (1:100, Vector, Burlingame, California) in mice with the avidin-biotin-HRP system (Vector) and 3′-5′-diaminobenzidine (DAB, Zymed, San Francisco, California) color substrate on 7-μm-thick paraffin-embedded sections (5,6). Photographs and measurements of histological sections were taken with an Olympus AX70 microscope (Olympus Optical, Tokyo, Japan) with analySIS imaging software (Soft Imaging System, Muenster, Germany) and were further processed for publication with Adobe Photoshop CS (Adobe, San Jose, California). The capillary mean area (μm2, measured along the outer surface) and total capillary vessel area of muscle area (i.e., fractional capillary area, %) were measured from 10 fields of CD31 immunostained sections of rabbit semimembranosus muscles at 200× magnification. All measurements were performed in a blinded manner.
Results are expressed as means ± SEM. Statistical significance was evaluated with analysis of variance followed by independent samples t test or the Kruskal-Wallis test, followed by Mann-Whitney U test where appropriate. Correlation analyses were performed by the Pearson and Spearman rho tests. A p value <0.05 was considered statistically significant.
CPS perfusion ultrasound imaging provides high spatial and temporal resolution.
The vascular effects of AdVEGF GT in rabbit semimembranosus muscles are shown by 3 independent imaging methods: blood volume-MRI, CEU, and CPS ultrasound (Fig. 2). Blood volume-MRI maps (ΔR2*) of AdVEGF and control AdLacZ-injected muscles show strongly increased blood volume in the AdVEGF transduced muscle and effusate surrounding the muscle owing to increased vascular permeability (Figs. 2A and 2B). The CEU imaging is capable of detecting only the large (>100 μm) vessels, whereas microcirculation is invisible (Figs. 2C and 2D). On the contrary, CPS ultrasound with IV-injected contrast microbubbles has a high spatial resolution allowing the detection of perfusion throughout the AdVEGF transduced muscle (Figs. 2E and 2F). Importantly, CPS efficiently subtracts echoes from the tissue and has a high frame rate (Figs. 2E and 2F, Online Video 1). In the CPS "mix" mode, blood flow and tissue can be imaged simultaneously, but then the quantification of the microbubble signal is more difficult (Online Video 2). Comparison of CPS imaging with histological capillary staining of the same muscle revealed that CPS is able to detect moving microbubbles in enlarged capillaries that are only 10 to 20 μm in diameter (Fig. 3, Online Video 3).
(A and B) Relative blood volume–magnetic resonance imaging (BV-MRI) performed with transversal plane contrast-enhanced T2*-weighted MRI with intravenous superparamagnetic iron oxide particles (Resovist) 6 days after AdLacZ or AdVEGF gene transfer. Shown are ΔR2* maps that demonstrate highly increased blood volume in the AdVEGF-injected semimembranosus muscle (brackets). (C and D) Contrast-enhanced power Doppler ultrasound (CEU) can detect blood flow only in large vessels, whereas in panels E and F, CPS ultrasound imaging at 8.0 MHz shows blood flow with a very high spatial resolution and effective tissue subtraction. Arrowheads indicate the profound femoral artery, and asterisks denote free fluid between muscles owing to AdVEGF-induced vascular permeability. See Online Videos 1 and 2. Abbreviations as in Figure 1.
(A) Transversal CPS imaging at 8.0 MHz in AdVEGF-injected semimembranosus muscle 6 days after gene transfer. Note the dark area inside the muscle showing little CPS signal, owing to low basal perfusion typical for intact skeletal muscle (surrounded by a green line). (B) A histological section of the same location as in panel A, covering the whole muscle and immunostained with the CD31 endothelial marker. Normal-sized capillaries colocalize with very low CPS signal inside of the area marked by a green line, whereas enlarged capillaries outside of the area colocalize with a good signal in CPS. (C and D) Higher magnifications of the regions marked with black boxes in panel B demonstrate a clear demarcation between the areas with normal (black arrows) versus enlarged (diameter 10 to 20 μm, red arrows) capillaries. Asterisks denote enlarged veins, and arrowheads indicate the profound femoral artery in panels A to C. Scale bar = 200 μm. See Online Video 3. Abbreviations as in Figure 1.
AdVEGF increases blood volume over 40-fold and perfusion over 20-fold in rabbit skeletal muscle.
Blood volume was increased as high as 41- and 51-fold as measured with blood volume-MRI and -CPS methods, respectively, 6 days after AdVEGF GT (Fig. 4A). The perfusion ratio between the transduced and contralateral intact limbs was also found to be very similar, elevated 20- to 24-fold, regardless of the method used (Fig. 4B). The correlations between the different methods were very high (Table 1,Fig. 4B). The shapes of the curves reflect different vessel types in the vascular bed (14): the presence of large arteries and enlarged capillaries without a normal capillary bed produces a steep curve with a high peak intensity (AdVEGF), whereas a normal vascular network with normal-sized capillaries yields a flat curve (AdLacZ) (6).
(A) Blood volume in the muscle is increased 41- to 51-fold after AdVEGF (n = 9) gene transfer (GT) as measured by BV-MRI and CPS ultrasound, respectively. (B) Perfusion is increased 20- to 24-fold after AdVEGF treatment, depending on the method used. (C) Arrival time is shortened in AdVEGF-injected muscles, reflecting a decrease in peripheral resistance owing to vessel enlargement. In contrast, MTT is increased after AdVEGF GT. (D) Capillary mean size is 29-fold larger in AdVEGF-treated muscles than in AdLacZ (n = 10) muscles. (E) Capillary density does not change after AdVEGF GT in 6 days. (F) Of AdVEGF-treated muscles, 9.2% are covered by capillary lumens, whereas normal capillary total area in AdLacZ muscles is 0.3%. *p < 0.05, **p < 0.01, and ***p < 0.001 versus AdLacZ. Analyzed by the Kruskal-Wallis test, followed by Mann-Whitney U test. Abbreviations as in Figures 1 and 2.
Microvessel enlargement in AdVEGF-treated muscles decreased peripheral resistance (time to arrival) significantly as compared with AdLacZ control muscles (Fig. 4C). In contrast, MTT was longer in AdVEGF-treated muscles (Fig. 4C). Figures 4D to 4F show histological parameters of capillaries in transduced muscles. As observed previously (6), AdVEGF strongly increases capillary mean size, although capillary density is not changed 6 days after GT (Figs. 4D and 4E). The capillary enlargement results in a 9.2% total capillary area of muscle area in AdVEGF transduced muscles (0.3% in AdLacZ muscles) (Fig. 4F). As expected, the perfusion increase and blood volume had a positive correlation with mean capillary size and total capillary area (Pearson test), whereas the arrival time had an inverse correlation with capillary size. Capillary density did not correlate with any of the parameters (Online Table 1).
CPS perfusion imaging in mouse hind limbs after angiogenic gene therapy.
We also tested the feasibility of CPS ultrasound imaging in the assessment of perfusion in mice hind limbs, because there is a shortage of methods capable of measuring real-time perfusion at the capillary level in mice. It was found that CPS has an excellent resolution also in mouse hind limbs (Figs. 5A to 5D, Online Video 4). In fact, because a higher frequency (14 MHz) can be used in mice than in rabbits (8.5 MHz), owing to a smaller ROI and a higher amount of contrast agent used in proportion to the body size, the spatial resolution is even better than in rabbits. Interestingly, CPS in mouse hind limbs revealed that intramuscularly injected AdVEGF induces angiogenesis mainly in the surrounding adipose tissue rather than in the targeted skeletal muscle itself (Figs. 5B, 5D, and 6,⇓ Online Video 4). This finding was confirmed by histological staining of capillaries (Figs. 5E to 5H).
(A to D) Normal power Doppler without contrast enhancement (left) and 14 MHz CPS imaging (right) 6 days after AdLacZ or AdVEGF gene transfer in mouse hind limbs. (A and B) AdVEGF induces angiogenesis and perfusion increases almost exclusively in the subcutis (brackets), probably owing to the low tropism of adenovirus in mouse skeletal muscle. The femoral artery is indicated by arrowheads. (C and D) Also in the calf, angiogenesis mostly occurs in the adipose tissue (brackets). Here, arrowheads denote the popliteal artery. Lectin capillary stainings of skeletal muscle (E and F) and subcutis (G and H) nearby. Although there are a few slightly enlarged capillaries in skeletal muscle (F, arrows), angiogenesis mostly takes place in the adipose tissue. Note red blood cells inside enlarged blood vessels (asterisks), indicating that the vessels are perfused. Scale bar = 100 μm. See also Online Video 4. Abbreviations as in Figures 1 and 2.
The AdVEGF (n = 6) increases perfusion by 2.7- and 2.5-fold in the thigh and calf muscles, respectively, 6 days after gene transfer. *p < 0.05 and **p < 0.01 versus AdLacZ (n = 6). Analyzed by analysis of variance followed by independent samples t test. Q1 = 25th percentile; Q2 = 50th percentile (median); Q3 = 75th percentile; other abbreviations as in Figure 1.
Imaging of growing vasculature and quantitative measurement of perfusion are very important in the assessment of clinical efficacy of angiogenic therapies. Strong vascular growth during therapeutic angiogenesis by overexpression of VEGF family members involving abundant capillary enlargement leading to capillary arterialization (6) and increased vascular permeability interferes with many current vascular imaging and perfusion measurement techniques. We found in this study that real-time CPS ultrasound imaging is a feasible and accurate perfusion measurement method after GT for therapeutic vascular growth in peripheral muscles of small and large experimental animals.
None of the current noninvasive perfusion measurement techniques, such as DCE-MRI, CT, SPECT, PET, laser Doppler, optical imaging methods, and previous ultrasound techniques, can provide simultaneous capillary level imaging at a high frame-rate, good penetration, efficient contrast agent separation from background tissue, and a contrast agent that is retained in leaky vessels. Contrast-enhanced steady-state MRI offers relatively good sensitivity and spatial resolution in vascular imaging, the possibility to perform whole organ scans, as well as functional imaging (3,6). However, in DCE-MRI, much of the spatial resolution must be sacrificed to get a sufficient frame rate for bolus tracking (6). Although highly sensitive, SPECT and PET both suffer from poor spatial resolution (3). Micro-CT is suitable for very accurate (up to 16 μm) postmortem anatomical vascular imaging, but the protocols for dynamic studies in vivo are less well established, in addition to well-known drawbacks of ionizing radiation and the low sensitivity of CT to contrast agents. Moreover, MRI and PET devices are not widely accessible to experimental researchers. Laser Doppler and optical imaging methods suffer from low resolution and poor tissue penetration (3).
In this study, we found that CPS perfusion measurement correlates well with that of DCE-MRI in rabbit skeletal muscle after angiogenic therapy. It was also feasible in mouse hind limbs where perfusion has been generally assessed by laser Doppler, which, however, penetrates only <1 mm in the skin. Importantly, CPS is technically less demanding, and the imaging protocol is much quicker than, for example, that of DCE-MRI. Of utmost importance is that large (>1 μm) microbubbles remain in circulation despite vessel leakiness (3,5,6). Here we used CPS at 8 and 14 MHz in rabbits and mice, respectively. A lower frequency in rabbits allows a better tissue penetration and a lower amount of contrast agent, owing to improved sensitivity, whereas in mice a higher frequency enables the visibility of the smallest vessels.
We found that the perfusion value calculated with the peak signal intensity after a bolus administration of the contrast agent correlated well with the perfusion value obtained by the gamma-variate function, which represents the standard analysis method after a bolus injection (10). Our data are supported by previous reports using both ultrasound and DCE-MRI showing a correlation between the peak enhancement and mathematical models (11,12). This finding is important, because the simple determination of the peak signal intensity from the data allows much quicker data analysis. The use of a continuous infusion of the contrast agent with the destruction-replenishment technique is widely used, especially in the myocardium, and has also been used in rat hind limbs (15). However, it is less practical in the skeletal muscle of big mammals, because of the low basal blood flow that would require very high amounts of infused contrast medium.
The findings herein show that AdVEGF elevates skeletal muscle perfusion as much as 20- to 24-fold 6 days after GT. It is obvious that this kind of acute and transient (<14 days) supraphysiological perfusion increase might not be therapeutically optimal, but instead, vectors like adeno-associated viruses are needed to promote more persistent angiogenesis without significant tissue edema as a side effect (1). In mice, the perfusion increase was much more modest as compared with rabbits, which is explained by the fact that angiogenesis occurred mainly in the adipose tissue and not in the injected skeletal muscle itself. The reason for this seems to be the poor transduction efficiency of mouse skeletal myocytes by adenovirus (16). The short arrival times (i.e., decreased peripheral resistance) and the steep shape of CPS signal intensity–time curve indicate the presence of large arteries and enlarged capillaries and the lack of a normal small-sized capillary bed after AdVEGF treatment (6,14). The delay in MTT in AdVEGF limbs is likely due to the recruitment of resting capillaries and strong capillary enlargement leading to increased blood volume in AdVEGF-treated limbs (17). It is noteworthy that capillary density did not change by VEGF overexpression over 6 days, nor did it correlate with any of the blood flow parameters.
Contrast-enhanced power Doppler ultrasound imaging has already been established in the assessment of skeletal muscle perfusion both in healthy volunteers and patients with peripheral arterial disease (18). We conclude that CPS ultrasound seems to be the next advance in the field of angiogenesis imaging and one of the most promising means for noninvasive follow-up of patients with peripheral arterial disease in clinical trials of therapeutic vascular growth.
In the past, there has been less experience on the analysis of blood flow with the bolus injection technique, whereas the corresponding algorithms are already well established in the method with a continuous contrast agent infusion and the analysis of destruction-replenishment kinetics. Thus, it is necessary to compare these 2 methods in the same experimental setting in the future. The usefulness of the CPS imaging settings used in this study could be limited in clinical use, because high frequencies feasible in smaller animals compromise the penetration of the beam in human skeletal muscle.
Technicians in the group of Molecular Medicine and at the National Experimental Animal Center at Kuopio University are acknowledged for their expert technical help.
For accompanying videos to Figures 2, 3, and 5, and a table depicting the correlation of parameters of blood flow versus histological analyses of vasculature, please see the online version of this article.
This study was supported by grants from the Academy of Finland, Finnish Foundation for Cardiovascular Research, Sigrid Juselius Foundation, EU Vascular Genomics Network, European Vascular Genomics Network (LSHM-CT-2003-503254), and EU CliniGene network (LSH-CT-2004-018933). Drs. Rissanen and Korpisalo contributed equally to this article.
Revision received October 12, 2007.
(2007) Current status of cardiovascular gene therapy. Mol Ther 15:1233–1247.
(2007) Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol 49:1015–1026.
(2005) Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst 97:172–187.
(2004) Contrast-agent detection and quantification. Eur Radiol, 14, Suppl 8:4–10.
(2003) VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adeno-viruses. Circ Res 92:1098–1106.
(2005) Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis. Circulation 112:3937–3946.
(2005) Assessment of skeletal muscle perfusion using contrast-enhanced ultrasonography. J Ultrasound Med 24:431–441.
(2007) Quantitative evaluation of muscle perfusion with CEUS and with MR. Eur Radiol 17:2663–2674.
(2001) Quantification of blood flow. Eur Radiol 11:1338–1344.
(2005) Modeling ultrasound contrast measurement of blood flow and perfusion in biological tissue. Ultrasound Med Biol 31:279–285.
(2002) Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis. NMR Biomed 15:132–142.
(2003) Comparison of intermittent-bolus contrast imaging with conventional power Doppler sonography: quantification of tumour perfusion in small animals. Ultrasound Med Biol 29:1093–1103.
ZJMedia Digital Technology. WinAVI Video Converter. Available at: http://www.winavi.com. Accessed November 29, 2007.
(2004) Analysis of refill curve shape in ultrasound contrast agent studies. Med Phys 31:623–632.
(2007) Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res 101:295–303.
(2006) Adenovirus vectors based on human adenovirus type 19a have high potential for human muscle-directed gene therapy. Hum Gene Ther 17:193–205.
(1995) Myocardial contrast echo effect: the dilemma of coronary blood flow and volume. J Am Coll Cardiol 26:12–17.
(2006) Contrast ultrasound perfusion imaging of lower extremities in peripheral arterial disease: a novel diagnostic method. Eur Heart J 27:310–315.


Time to disengage? Two interviews.
The relationship between internal communication and employee engagement was the subject of two discussions published this week – a half-hour podcast with the UK's "Engage For Success" movement, and the latest Chuck Chat, an interview written in real time with Chuck Gose, who makes a massive contribution to the #internalcomms tribe with his podcasts, postings and interviews..
The podcast can be found at BlogTalkRadio, and the interview can be found on the blog site of Chuck's sponsor, Bananatag.
For me, it's heartening to continue to get air time for the idea that internal communication and employee engagement have become too close. As I see it, internal communication is strategically handcuffed by the need to align with employee engagement's focus on shaping and measuring the attitudes of all employees. In turn, the internal comms-driven drumbeat for ever-higher engagement survey scores and participation stifles the development more tailored and individually "engaging" programming from the employee engagement community.
Whether this conversation will catch on is anyone's guess.
Not so long ago, such thoughts could easily have been classified as heresy akin to "employee engagement denial." Now, thanks to Chuck Gose and Exchange For Success, there's a willingness to sponsor and start the discussion, an absolutely critical and welcome step. Please feel free to join in.
Next postWhat can M&A communication learn from a wedding in Iceland?


Epicor Software Corp. has introduced a new workflow product, Epicor Smart Inspection 2.0, designed to help shops more quickly diagnose, document and estimate repairs.
Users of the device, which is optimized for use on mobile devices, begin an inspection by scanning a VIN or manually entering make, model and year information. This data triggers associated specifications and part and labor lookups via the Epicor PartExpert eCatalog. Optional integration with select vehicle diagnostic tools also is available.
The service writer or technician uses the inspection results and associated parts and labor lookups to assemble and email (or print) a comprehensive estimate, including photos, for customer approval. The product also allows users to view pricing and availability of parts and related supplies via connected local suppliers, and to order these items with a click.


text:
Uta Schmidt (* 1965 in Marburg) ist eine deutsche Filmeditorin.

Leben und Werk
Uta Schmidt begann ihre Karriere 1987 als Schnittassistentin bei diversen Kinospielfilmen, unter anderem Homo Faber (1991, Regie: Volker Schlöndorff), und  Justiz (1993, Regie: Hans W. Geißendörfer). Seit 1994 arbeitet sie als freie Editorin, sowohl im Kino- als auch im Fernsehbereich.

Für ihre Montage-Leistung bei dem Spielfilm Vier Minuten des Regisseurs Chris Kraus, wurde Uta Schmidt 2007 mit dem Deutschen Kamerapreis geehrt (Kategorie: Bester Schnitt Kinospielfilm), und war für den Deutschen Filmpreis nominiert. 2008 gewann sie für den TV-Krimi Bella Block: Reise nach China den Deutschen Kamerapreis in der Kategorie Bester Schnitt Fernsehfilm.

Neben ihrer Tätigkeit als Editorin unterrichtet Uta Schmidt an der Deutschen Film- und Fernsehakademie Berlin (dffb). Sie ist Mitglied im Bundesverband Filmschnitt Editor e.V. (BFS), und in der Deutschen Filmakademie, wo sie von 2009 bis 2013 als Repräsentantin der Sektion Musik/Schnitt/Tongestaltung im Vorstand aktiv war.

Filmografie (Auswahl)
 1997: Zuckerstücke – Regie: Arielle Artsztein
 1998: Der Strand von Trouville – Regie: Michael Hofmann
 1999: Fremde Freundin – Regie: Anne Høegh Krohn
 2001: Mutanten – Regie: Katalin Gödrös
 2002: Geld Macht Sexy (TV-Spielfilm) – Regie: Anne Høegh Krohn
 2003: Ich liebe das Leben (TV-Spielfilm) – Regie: Anna Justice
 2004: Jargo – Regie: María Sólrún Sigurðardóttir
 2005: Almost Heaven – Regie: Ed Herzog
 2005: Noch einmal lieben (TV-Spielfilm) – Regie: Anna Justice
 2006: Vier Minuten – Regie: Chris Kraus
 2006: Schwesterherz – Regie: Ed Herzog
 2007: Max Minsky und ich – Regie: Anna Justice
 2008: Bella Block: Reise nach China (TV-Reihe) – Regie: Chris Kraus
 2009: Ein Mann, ein Fjord! (TV-Spielfilm) – Regie: Angelo Colagrossi
 2010: Poll – Regie: Chris Kraus
 2011: Die verlorene Zeit – Regie: Anna Justice
 2012: Schatzritter und das Geheimnis von Melusina – Regie: Laura Schroeder
 2013: Willkommen bei Habib – Regie: Michael Baumann
 2014: Göttliche Funken (TV-Spielfilm) – Regie: Maria von Heland
 2014: Kein Entkommen (TV-Spielfilm) – Regie: Andreas Senn
 2015: Verfehlung – Regie: Gerd Schneider
 2015: Im Namen meines Sohnes (TV-Spielfilm) – Regie: Damir Lukačević
 2015: Besuch für Emma (TV-Spielfilm) – Regie: Ingo Rasper
 2016: Aufbruch (TV-Spielfilm) – Regie: Hermine Huntgeburth
 2017: Happy Burnout – Regie: André Erkau
 2018: Tatort: Der kalte Fritte (TV-Reihe) – Regie: Titus Selge
 2019: Polizeiruf 110: Dunkler Zwilling (TV-Reihe) – Regie: Damir Lukačević
 2021: Nord bei Nordwest – Ho Ho Ho!

Auszeichnungen

Preise
 2007: Deutscher Kamerapreis in der Kategorie Bester Schnitt Kinospielfilm für Vier Minuten
 2008: Deutscher Kamerapreis in der Kategorie Bester Schnitt Fernsehfilm für Bella Block – Reise nach China

Nominierungen
 2007: Deutscher Filmpreis in der Kategorie Schnitt für Vier Minuten
 2007: Filmplus Schnitt Preis in der Kategorie Spielfilm für Vier Minuten
 2011: Filmplus Schnitt Preis in der Kategorie Spielfilm für Poll
 2011: Preis der Deutschen Filmkritik in der Kategorie Schnitt für Poll
 2015: Filmplus Schnitt Preis in der Kategorie Spielfilm für Verfehlung

Literatur
 Béatrice Ottersbach; Thomas Schadt (Hrsg.): Filmschnitt-Bekenntnisse. UVK-Verl.-Ges., Konstanz 2009, ISBN 978-3-86764-138-8.

Weblinks

 Uta Schmidt beim Bundesverband Filmschnitt Editor e.V. (BFS)
 Kurzportrait von Uta Schmidt 2010 auf Deutsche Welle–TV
 Interview mit Uta Schmidt beim Filmportal 24 der Deutschen Filmakademie

Einzelnachweise

Filmeditor
Mitglied im Bundesverband Filmschnitt Editor
Mitglied der Deutschen Filmakademie
Deutscher
Geboren 1965
Frau

redpajama_set_name: RedPajamaWikipedia


text:
MediaDefender DoS attack on Revision3: Stop screwing with new media
Earlier today, I saw Jim Louderback, CEO at Revision3, tweeting that there had been an outage at Rev3 this weekend and he could now shed light on the issue. Honestly, I hadn't noticed the downtime. I've got Diggnation, The Totally Rad Show and Web Drifter being drip-fed into my iPhone (via iTunes sync) and watch the shows when I'm on the train/tube looking for something to do. I've also got a total school-girl crush on Alex Albrecht, which makes the show all too easy to watch, but I digress…
I expected the downtime to be Twitteresque in its incapacity to deal with our adulation and traffic. However, Jim's story shows the issue they faced this weekend was a whole more serious.
In a nutshell, Revision3 exploits the fantastic peer-to-peer system that is BitTorrent to distribute its shows. Rev3 hosts the tracker, but doesn't have to take the weight of every single download. It makes technical sense – the Rev3 crowd are technologically up to date and love BitTorrent. It makes business sense – Jim doesn't have to put quite so much of his revenue towards more servers just to cope with the peaks of traffic, he can count on the distributed network. And it fits right in with the attitude of the Rev3 shows, irreverently addicted and up to date to the latest technology.
Jim writes… "But someone, or some company, apparently took offense to Revision3 using Bittorrent to distribute its own slate of shows. Who could that be?
Along with where it's bound, every internet packet has a return address. Often, particularly in cases like this, it's forged – or spoofed. But interestingly enough, whoever was sending these SYN packets wasn't shy. Far from it: it's as if they wanted us to know who they were.
A bit of address translation, and we'd discovered our nemesis. But instead of some shadowy underground criminal syndicate, the packets were coming from right in our home state of California. In fact, we traced the vast majority of those packets to a public company called Artistdirect (ARTD.OB). Once we were able to get their internet provider on the line, they verified that yes, indeed, that internet address belonged to a subsidiary of Artist Direct, called MediaDefender."
MediaDefender was the one hitting Revision3 servers with a Denial of Service attack. (Read Jim's post for details on who MediaDefender is and what denial of service attacks are. I'll skim over that bit.)
According to my eye witnesses, MediaDefender received a less-than-warm reception at South by SouthWest when Randy Saaf, CEO at MD, took part in a panel on "How Piracy Will Safe the Music Industry", where the legitimacy of such a service was questioned by the audience and fellow panelists.
Revision3 is out there, showing off BitTorrent in a good light, using it for legal and completely legitimate purposes, and in comes MediaDefender, like a bull in a china shop, crushing their servers. It's naive on Revision3's part to fail to keep a closer eye on their trackers and letting MediaDefender inject their torrents unauthorised for such a long time, but it doesn't justify MD's backhanded and disgusting behaviour.
Jim chose his words carefully and expressed the issue very clearly – For this, I'm very grateful, as it exposes MD as a total fraud blindly attacking legal and illegal services.
It's hard enough being at the cutting edge of any technology without needing twisted organisations like the RIAA, MPAA and Sony hiring online hitmen to destroy perfectly legitimate of technology! I'm not personally a very active BitTorrent user these days, but I'm livid about this.
I hope that Jim, the Revision3 crew and all other technophiles making legitimate use of geekery like BitTorrent see this as a rallying call and an opportunity to educate people. There's too much good technology out there to let old technophobes in their ivory towers dictate where we can go with it.
Web & TechnologyVerobittorrent, business, diggnation, file-sharing, legal, revision33 comments
I'm a SOB apparently
The Letter in the Pond
3 thoughts on "MediaDefender DoS attack on Revision3: Stop screwing with new media"
Jaimesh Mistry
That article by Jim Louderback was incredile, I never knew he could write like that.
JAB_au
It's pretty amazing what big faceless companies think they can get away with, yes it's you I'm talking about you MediaDefender. Unlike an individual they will never face the music for their crime, it's left to Revision3 to sue them. Even though what they have done is a criminal activity, dare I say Terrorist attack, they wont be prosecuted criminally.
"How Piracy Will Safe the Music Industry"
*Save


I'm working on another spreadsheet showing the 4th quarter fundraising summaries for Statewide races. The totals for Governor are in there now and I'll add others as I have time this afternoon.
Cagle has $750,000 on hand for the LG race.
You should add a column for the fluff (loans).
A very good idea. It does make a big difference in determining who has support and who has personal funds.
Has anybody heard why McBerry has not filed?
This is still up in the air. One camp says President of Georgia, the other says Grand Dragon.
Seriously, though, last night I heard a rumor that he has cancelled some campaign events for some kind of big announcement. My first thought that was maybe he was going to announce that he was going to run as an independent to attempt to tap into "tea party" voters.
Ligon is not running for AG. The numbers you provided are his numbers for State Senate.
His AG report even says "Final Report and Termination Statement".
What in the world? A negative mark for reporting correct info? LOL.
Sorry, thought I posted here to thank Ic for the good format and information.


text:
Q: catch ids with 'for' in js help pls I want to catch 10 inputs with JS, and put all them in a array[10], but I dont know any method to do this yet, I tried searching and all i could find was this, but doesnt seem to work.

var i = 0;
var menor, maior;
function fibonacci() {

}
function calcularMenor() {

}
function calcularMaior() {
    var n = new Array();
    for(i = 0; i < 10; i++) {
        var input = "input";
        var inputNumber = "" + i.toString();
        var inputId = input.concat(inputNumber);
        n[i] = document.getElementById(inputId).innerHTML;
    }
    document.getElementById("result").innerHTML = n[1];
}
<!DOCTYPE html>

 <title>Exercicio com Arrays</title>
 <meta charset="utf-8">

 <link rel="stylesheet" type="text/css" href="style.css">
 <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.1/css/bootstrap.min.css" integrity="sha384-WskhaSGFgHYWDcbwN70/dfYBj47jz9qbsMId/iRN3ewGhXQFZCSftd1LZCfmhktB" crossorigin="anonymous">

    <fieldset>
     <legend>Sequência de Fibonacci:</legend>
     Limite Fibonacci: <input type="number" id="numFibonacci" min="1" value="1">

     <button>Exibir elemento na posição</button>
    </fieldset>

    <fieldset>
     <legend>Vetor</legend>
     <input type="text" name="inputVetor" id="input0">
     <input type="text" name="inputVetor" id="input1">
     <input type="text" name="inputVetor" id="input2">
     <input type="text" name="inputVetor" id="input3">
     <input type="text" name="inputVetor" id="input4">
     <input type="text" name="inputVetor" id="input5">
     <input type="text" name="inputVetor" id="input6">
     <input type="text" name="inputVetor" id="input7">
     <input type="text" name="inputVetor" id="input8">
     <input type="text" name="inputVetor" id="input9">
    </fieldset>
    <button name="exibir" onClick="()">Exibir MAIOR elemento</button>
    <button name="exibir" onClick+"()">Exibir MENOR elemento</button>

At the moment I want to work only on the 'vetor' div, the fibonacci code i'll do it later

A: hay paulo, you can get values and put that value into array like:
let dataArray = []
for(i = 0; i < 10; i++) {
    dataArray.push(document.getElementById(`input${i}`).value);
}
alert(dataArray);
document.getElementById('numFibonacci').value = dataArray

initialise an array and put values one-by-one in that array.
Here is your full code.
<!DOCTYPE html>

    <title>Exercicio com Arrays</title>
    <meta charset="utf-8">

    <link rel="stylesheet" type="text/css" href="style.css">
    <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.1/css/bootstrap.min.css" integrity="sha384-WskhaSGFgHYWDcbwN70/dfYBj47jz9qbsMId/iRN3ewGhXQFZCSftd1LZCfmhktB" crossorigin="anonymous">

                <fieldset>
                    <legend>Sequência de Fibonacci:</legend>
                    Limite Fibonacci: <input type="number" id="numFibonacci" min="1" value="1">

                    <button>Exibir elemento na posição</button>
                </fieldset>

                <fieldset>
                    <legend>Vetor</legend>
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6-foot spreader for implement mounting. 9 cu. ft. hopper with approximately 600 pounds of capacity (1.5 cu. ft. capacity per foot). Includes hydraulic shut-off, weather-tight removable and reversible covers with spill guards and dual lock-down latches. Diamond-shaped openings spaced 4-inches apart for a total of 18 openings. Note: 1/4" hydraulic hoses and 1/4" NPT pipe thread fitting for hydraulic shutoff supplied by user.
8-foot spreader for implement mounting. 12 cu. ft. hopper ;with approximately 800 pounds of capacity (1.5 cu. ft. capacity per foot). Includes hydraulic shut-off, weather-tight removable and reversible covers with spill guards and dual lock-down latches. Diamond-shaped openings spaced 4-inches apart for a total of 24 openings. Note: 1/4" hydraulic hoses and 1/4" NPT pipe thread fitting for hydraulic shutoff supplied by user.
10-foot spreader for implement mounting. 15 cu. ft. hopper with approximately 1,000 pounds of capacity (1.5 cu. ft. capacity per foot). Includes hydraulic shut-off, weather-tight removable and reversible covers with spill guards and dual lock-down latches. Diamond-shaped openings spaced 4-inches apart for a total of 30 openings. Note: 1/4" hydraulic hoses and 1/4" NPT pipe thread fitting for hydraulic shutoff supplied by user.
12-foot spreader for implement mounting. 18 cu. ft. hopper with approximately 1,200 pounds of capacity (1.5 cu. ft. capacity per foot). Includes hydraulic shut-off, weather-tight removable and reversible covers with spill guards and dual lock-down latches. Diamond-shaped openings spaced 4-inches apart for a total of 36 openings. Note: 1/4" hydraulic hoses and 1/4" NPT pipe thread fittings for hydraulic shutoff supplied by user. Electric or hydraulic drive ordered separately; if hydraulic drive is selected, user supplies 1/2" hydraulic hoses from tractor to drive and 1/2" NPT fittings.


Every tech professional has a story, a moment when interest in a certain piece of hardware or software sparks a lifelong love of working in technology. In that moment, the individual knows what they're meant to do. For SQL expert Jim Horn, that moment hit him twice in his life. First at 13 years old while working on Atari 400 and Commodore 64 computers, learning basic programming for both classroom assignments and as a personal hobby. And second, after a few years spent working as an accountant. He realized he had it right at 13 and proceeded to make a career change.
"[I] began a five-year, two-job transition back to computer science as a Microsoft Access database developer, which eventually led to SQL Server and Visual Basic, which became SQL Server only since 2006," Horn said.
We wanted to know more about his pursuit of a career in SQL, as well as his involvement in SQLSaturday, a free training event held every year in Minnesota. Read on for the rest of the interview.
Experts Exchange: What piqued your interested in learning SQL?
Jim Horn: When I transitioned my career from being an Accountant to an IT person, Microsoft Access was a very convenient database application with a low barrier to entry where I could be productive very quickly. So I learned Access on my own and through various local training centers, and eventually became good enough at it to be a full-time Access developer.
From there I eventually worked on larger databases, so I picked up SQL Server, and eventually did that full time.
EE: How do you use SQL in your day-to-day job? And what part of SQL work do you most enjoy?
JH: As the Data Architect for an entire company I spend my entire day in SQL: writing it for data warehouses, applications, and reports, reviewing the work of other developers, troubleshooting, setting up various maintenance jobs, modeling, performance tuning, and deploying it via Team Foundation Server. I also perform a lot of business unit liaison duties for database projects.
My favorite would probably be the modeling databases and performance tuning, something I don't do enough as I get bombarded with lots of other requests. Like a lot of people, no matter what your specialty is, you spend a certain amount of your time answering emails in Outlook and sitting in meetings.
EE: What do you see happening in the future of SQL as server technologies/relational databases change?
JH: Microsoft SQL Server will probably follow market trends like in recent years past, with easier to use cloud options, BI tools, data warehousing, and integration with other data sources.
I'd love for Microsoft to invest more in the SQL Server Integration Services (SSIS), but that hasn't happened since 2012. In 2012, I asked a Microsoft engineer [about that] and the joking answer was because Xbox made too much money, Microsoft decided to throw a lot of their development effort there. That's the unofficial answer of course.
My guess is the actual is answer is, you know, like anything else, Microsoft has to determine market share and revenue opportunities and right now they have SSIS bundled into the Visual Studio Suite, not as a standalone, so what ends up happening is a lot of companies with enterprise licensing will get SSIS too, there's not add-on revenue.
There are many competitors.... and I don't know if Microsoft has figured out how to capitalize on their ETL tool and make it more profitable. From where I sit, though, SSIS is a pretty big learning curve. It's not SQL server specific. You've got a query language and data sites that have to be able to handle pretty much anything under the sun, so the Microsoft SQL server data types will not automatically directly translate into SSIS data types. The [user interface]....well, 2012 was when they made some big improvements, but still, Microsoft has not put a lot of development into SSIS.
EE: You've completed the following Microsoft exams: 70-461 Querying Microsoft SQL Server 2012 (2013), 70-069 Microsoft Access for Windows 95 (2000, MCP status), and 70-051 Microsoft Access Application Development (1998). Which was most difficult to pass?
JH: Probably the two Access exams, as before 2012, Microsoft certification exams required deep and varying knowledge, and the questions resembled a Trivial Pursuit game. Since 2012, Microsoft has changed their lower-level professional exams to be more of how they are used and less trivia.
EE: What helped you prepare for these exams?
JH: Experience, as test exams and books only help you refine the skillsets you already have, and without the experience I can't see how anyone would pass the exam. I recommend buying the MSPress book used from eBay, which will be pre-marked and often have tips for passing the exam from the previous owner. Then when you're done, you can sell the book back.
EE: You participated in SQLSaturday in Minnesota this past weekend (October 7th). Please tell us a little background about your participation in this event.
JH: I've been involved with SQL Saturday for the last five years. The last two years I was one of the organizers, and last year I was the head organizer for the event.
For the first three years as an attendee you get to choose from five time periods, any of seven classes, all taught by established experts. Some gifts such as a T-shirts are provided by the event and vendors. This event is truly the best free training day around.
As an organizer, we have to handle lots of different areas, such as soliciting presentations, choosing which presentation to accept, marketing, working with the parent PASS organization, finding a facility to host the event, provide WiFi and food service [options], and finding sponsors to pay for the event and host a table. Experts-Exchange was a sponsor in both 2013 and 2016.
I was one of the presenters in 2013, 2015, and 2017, all based on content I had written for an article on Experts Exchange. Presenting technical content puts you in a higher class of technical person, as when interviews come and hiring managers ask, "Do you know X?", not only can you say yes, but also that you've taught classes in X, and—in my case—written articles in X.
This can be invaluable in getting jobs and contracts, as many people in IT will often embellish or lie on their resumes in order to get work, and then attempt to learn the skills on the employer's nickel.
EE: In what ways do you believe continuing education opportunities like this help technology professionals grow their skill set?
JH: Many technology professionals become the sum of what their employers ask them to do and pay for, and with whatever version of SQL Server the employer runs, and the tools they own. So continuing education helps experts break out of a current employment situation with more skills and helps them do better jobs.
There's also a lot of competition with people coming to the U.S. for programming jobs, combined with the propagation of worldwide outsourcing and work-from-home for many technologies, and this increase in supply puts downward pressure on salaries. So anything you can do to be perceived as a higher expert helps.
I'm genuinely surprised more people to do not take advantage of free training opportunities.
EE: We know Database Administrators and Developers should know SQL, but what are some other career paths that would benefit from knowing SQL?
JH: This is hard to answer as there are many user-friendly query builders that non-programmers can use to query databases and return meaningful information. And with the use of SSAS and the Power BI suite, Microsoft enables developers to frame up data sets for non-technical people to use in a way that does not require writing any SQL.
EE: What types of courses or certifications do you recommend for individuals wanting to learn SQL?
JH: The only certification path I am aware of for Microsoft SQL Server is their own. Get the experience, then buy some MSPress books to review your skillsets to make sure you have everything you need to take the exam, then take it.
EE: Database software like Microsoft, Oracle, IBM, Sybase can have variations in SQL syntax. How can individuals best adjust SQL knowledge from one database software to another?
JH: Most database languages I've seen are at least 70% similar, so it is not hard to write in another language. There are many other facets of database work that have very unique languages that have a steep learning curve, such as VB.NET and C#.NET scripting for SSIS, MDX and DAX for data analysis, and R for statistical analysis.
EE: What are some of the tools/clients you use to connect to a database?
JH: Mostly applications written by in-house developers using ASP.NET or Java. Some SSIS and SSRS.
How are you working to learn SQL? Tell us in the comments below.


My mother also got the gene, but not me. I burn pretty much everything I touch. However, my husband is an incredible cook, giving me even more reason to stay away. Ever since I became pregnant with my second, I've had this urge to start baking. I've found it's not only satisfying, but it's such a nice activity to do with my mom. I'm juggling a full time job, while pregnant with a one year old, as you can imagine that quality time is shrinking. So, no matter your age or level of expertise, grab a family member and bake. There's just something about it that I can't explain, especially over the holidays. I guess it brings me back to childhood watching my grandmother Minnie dominate the kitchen.
The only thing I was solely in charge of was baking the pie that ended up being a bit burnt. I guess you can't change those genes after all.
We used a great food52 recipe you can find HERE. The only change we made was we halved the pastry recipe to make one double pie crust. The filling is for one pie as is.
HERE is a link to the perfect pie tips! I Wish I read this before I burnt this masterpiece. Hint: Put foil around the edges to prevent burning. To those of you who reached out with that advice, thank you!


St. Theophan Academy: Happy St. Brigid Day!
Your new stand looks just lovely and cleaning out your pantry sounds like a great idea...we always just walk down the road to visit the sheep. We keep saying we are going to make butter but when we start whipping the cream we never get past the whipped stage..it looks to tasty at that point! A very happy day to you!
your pantry is lovely! :) blessed day and week to you!!
I'm admiring your pantry and your seasonal corner. I can't help wondering if those are trees from Europe (Ostheimer?) or if you have a clever someone who made them with the directions from Wee Folk Art. I would love to do that!
Maria - those trees were a very gracious gift from a sweet blogger who made the most amazing peg people saints. She closed down her blog and I have been out of contact with her for quite a while (she went by Leah online). She did use the patterns from Wee Folk Art. I have made a few of the trees using their patterns, sadly they are waiting to be painted - another project I hope to get to sometime.


What should I include in an Amazon Machine Image (AMI)?
Amazon Web Services (AWS) offers its customers several methods that make it easier to provision Amazon Elastic Compute Cloud (Amazon EC2) instances and store instance configurations across a variety of different server and application deployment models. The most common unit of management is the Amazon Machine Image (AMI), which provides the information required to launch an EC2 instance. AWS customers specify an AMI when launching an instance and can use a single AMI to launch multiple EC2 instances. This webpage provides AWS customers with strategic guidance and common methods for determining what software to include in the image when building custom AMIs.
The following sections assume basic knowledge of Amazon EC2 and supported operating systems, image-based OS deployment, and configuration management systems.
Avoid embedding passwords, private keys, or other sensitive information in AMIs.
Leverage AWS CloudFormation or a third-party configuration management tool to document and automate AMI creation and updating.
Create a library of reusable, modular templates that can be programmatically assembled to create different types of AMIs.
Instrument AMIs with a standard bootstrapping capability that allows the instance to reference runtime information at launch.
Develop a consistent strategy for tagging AMIs to allow for the easy organization and identification of images and their contents.
AMI design options fall along a spectrum of deployment simplicity in relation to deployment flexibility. The simplest AMIs are fully baked and purpose-built to deploy a complete running instance, including the installation and configuration of all required software. However, this approach limits flexibility, as a fully baked AMI can only be used to deploy a single instance or a farm of identical instances. The most flexible AMIs include only minimal configurations and software before then dynamically installing the required packages on first boot. This approach trades simplicity for flexibility as each instance must be properly bootstrapped before it can function as intended.
How quickly do you need to be able to recover a failing instance or add additional compute capacity?
Does the workload's baseline stay static for a relatively long period?
Does your server configuration require manual provisioning or configuration?
Do you need to minimize the complexity of deploying resources to both AWS and on-premises environments?
Are there existing server provisioning tools or processes that you are trying to align with AWS?
On one end of the spectrum is the most common method for AMI design that provisions a fully functional instance, including all necessary software for a specific role or even a single instance. Organizations often create a baseline AMI that conforms to minimal security and configuration requirements, and then build on this baseline to create fully baked AMIs that are specific to applications or infrastructures for actual instance deployment.
Fully baked AMIs are the simplest to deploy and provide the fastest launch times. For this reason, fully baked AMIs are useful to quickly deploy replacement instances or add additional capacity. Fully baked AMIs also require minimal changes when launched and can be used to capture manual installation and configuration steps that cannot be automated. The process of using fully baked AMIs is similar to how many organizations deploy virtual servers in their existing data centers, which makes this simple approach applicable to customers who are new to the AWS platform and are accustomed to image-based server deployments.
At scale, it can be expensive and cumbersome to maintain unique AMIs for every instance or group of instances. This approach is therefore more suitable for smaller AWS deployments or when combined with an automated AMI build and management system. Even though this approach deploys a fully functional system, AWS highly recommends including a mechanism to read and process EC2-instance user data at launch. It is often advantageous to be able to pass launch instructions for minor configuration changes to your OS or application, such as those specific to a region, availability zone, or lifecycle environment.
At the other end of the spectrum is the just enough operating system (JeOS) approach. This approach creates an AMI that combines a minimal operating system with a configuration management agent that builds a fully functional system at instance launch. On first boot, the configuration agent downloads, installs, configures, and integrates all required software.
JeOS AMIs offer the most flexibility during deployment and the highest levels of portability because they leverage minimal server images. Customers who prefer this approach typically have experience with AWS and configuration automation tools. They want deployment flexibility to be able to pull the latest software builds and updates at launch, or they might require minimal complexity in order to deploy resources to both AWS and on-premises environments.
Downloading, installing, and configuring all required software on first boot can significantly increase instance launch times, making this approach less suitable for quickly replacing a failed instance or adding capacity. Also, JeOS AMIs require tight coupling with a configuration management system and can be more difficult to use with legacy software that typically has limited automation capabilities.
Hybrid AMIs provide a subset of the software needed to produce a fully functional instance, falling in between the fully baked and JeOS options on the AMI design spectrum. This approach creates a partially baked, generic infrastructure AMI that is further configured on first boot based on specific application requirements. The decision about what to bake into the AMI and what to install and configure at launch is typically based on how reusable the underlying software package is across all instances and how long it takes to download, install, and configure the software component. For example, to reduce instance launch times, include server management agents and baseline security configurations into an AMI. To further reduce instance launch times, include the necessary software to create role-specific AMIs (e.g., web servers, application servers, database servers).
Hybrid AMIs combine the flexibility of post-launch changes with the speed of preinstalled and preconfigured infrastructure components. This can be especially useful for merging frequently changing software (such as application code or security updates) with infrequently changing software (such as management agents and security baselines). Customers who use this approach typically have a moderate amount of experience with AWS and configuration automation tools, and want to combine the deployment simplicity of a baked image with the deployment flexibility that pulls the latest software builds and updates at launch.
Be aware that each change to software that is tightly coupled with the AMI requires a new AMI to be built. Although this approach requires fewer AMIs to maintain than the fully baked AMI approach, it will still result in more AMIs to maintain than the JeOS approach. We therefore recommend that customers who take this approach combine it with an automated AMI build-management system and a configuration management tool.


I got my BSG starter today...why didn't my set include the Cylon decoder?
Nah, it's actually a Martian signal. They are wondering why the invasion hasn't kicked off!
. . . they want to know where the heck their T & T KICKSTARTER invaision fleet is as well . . .
National POLO SHIRT ORDER FORMS.


Summons a Windfury Totem with 5 health at the target destination for 60 sec. If the totem is destroyed, Windfury Totem incurs a 30 sec cooldown.
Windfury Totem enchants all allies' weapons within 10 yards with wind causing attacks to have a 40% chance to generate an additional 3 extra attacks, dealing (100% of weapon damage) Physical damage.


I had reason, recently, to think back on Alfred Hitchcock's Strangers on a Train, particularly about the final scene on the merry-go-round or, more formally, the carousel.
That reminded me of the old carousel that used to sit diagonally across Surf Avenue from the Cyclone roller-coaster. It is gone now, but I loved it as long as I could, finding any excuse for taking a child upon it, reaching out for the brass rings and listening to the calliope as we spun around it.
He turned away and collected the next fare.


text:
BOU AVENUE
Keremeos Columns (3 April 2001)
Horsing Around In Summerland (4 April 2001)
Carbon Glacier (9 April 2001)
Harrison Lake (11 April 2001)
Skaha Bluffs (13 April 2001)
Cox Hill (12 May 2001)
Three Sisters Pass (26 May 2001)
Tent Ridge Horseshoe (23 June 2001)
Turtle Mountain (2 July 2001)
Mount Nestor (7 July 2001)
Mount Arethusa (14 July 2001)
Top Of The World Provincial Park (19-22 July 2001)
Crowsnest Mountain (4 August 2001)
Mounts Niblock And Whyte (11 August 2001)
Caldron Lake (26 August 2001)
Mount Inglismaldie (15 September 2001)
Mount Tecumseh (22 September 2001)
Unnamed Peaks At GR322455 (30 September 2001)
Kirkland, Washington (5-9 April 2001)
Mount St. Helens (7 April 2001)
Bloedel Conservatory (10 April 2001)
Grand Beach (26-29 July 2001)
Mom's Birthday (10 August 2001)
Dan Millar's Birthday (16 September 2001)
Marcela Deuma's Wedding (29 September 2001)
Dinner Party (15 December 2001)


The church, which was built in the 17th century, is located within the Hamlets of Antera and that of Madonna delle Grazie. It has, over the centuries, been subjected to various restorations and today appears in its 19th century appearance.
It was donated in perpetuity to the SS. Rosario Confraternity on January 17, 1760 - according to an act by the notary T. Melchiorre - which was then recalled several times because the confratenity didn't have a headquarters where they could keep the "bags" and the vestments.
On the outside of the church there is a crowned, straight facade overwhich is a semi-circular painting showing the figures of the Virgin with child, St. Dominic and St. Catherine.
Inside the rectangular room, which at one time was covered with a barrel vault and has now been replaced by an anonymous flat ceiling, there is a wooden sculptural group of the Madonna of the Rosary and child which, together with St. Dominic and St. Catherine, is carried on the shoulders by the lay brothers of the Rosary during the procession through the main streets of the town on the first Sunday of October. It should also be noted that there is a painting of the Virgin of the Rosary with the fifteen mysteries.


Fine dining year-round and elegant catering (plan your next function now!) Winter hours Tuesday - Saturday 5pm, bar 4pm. Champagne Sunday Brunch, 9:30-12:30. Serving Mother's Day Brunch 10am-3pm. Summer hours - open nightly.
Serving Dinner Tuesday-Saturday 5pm, Bar 4pm. Champagne Sunday Brunch 9:30-12:30.


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