In high torque, high-load situations, the torque converter bears the brunt of the engines force. Stock torque converter stator pitch designs slip excessively, causing the oil to foam and ever heat, and the front cover clutch surface to warp. But BDs torque converter was specifically designed to handle the kind of punishment you dish out.
Core charges will be refunded once your core is processed at BD Diesel.
Built on our premises in a state-of-the-art transmission facility, BD converters feature a heavy duty stamp forged steel cover, much thicker than stock and it is actually stronger than steel billet. We double the amount of lock up clutch material of a stock unit. We furnace braze the turbine and impeller fins to prevent internal leakage, turbine and lock up piston are balanced separately and then as a complete assembly. Turbine to impeller clearance and over all convertor height is verified. Our own cast aluminum stator design maximizes the low-speed torque characteristics of the Cummins engine and we even have high rpm stall stators for those race applications.
On the street, you'll notice that stall speed is reduced significantly, resulting in more positive engagement in drive, enhanced low-speed drivability, less engine rpm and better fuel economy. If you tow or just use a daily driver, you'll appreciate that this model convertor is designed to handle up to 1,000 lb.-ft of torque. It does not have a hard engagement; it is designed for high power towing applications.


The study combined automated listening and processing with manual analysis of social media data by qualified analysts and physicians.
Lexical entities referring to switching between oral, injectable and iv therapies for MS, identified by brand name, were captured from extracts of relevant online conversations.
1,684 data points were collected for treatment switches, which were most prevalent among patients in injectable MS therapies and least prevalent among those on iv therapies.
therapies (25%). Side-effects, lack of efficacy and physician advice were the most common reasons given for a change of medication, while around 14.5% of the MS patients switched from injectables to oral therapies due to ease of use.
The researchers concluded that social media intelligence was a powerful tool for outcomes research, providing insights into specific aspects of health-seeking behaviour that might not be available through other research channels, and in a population that appeared to be representative of patients engaged in real-world medication switching.
The study demonstrated that social media analytics, based on observations from real-world healthcare utilization and claims databases, could be used to quantify treatment-switching patterns and identify factors underlying switching behaviour in a defined patient population.
A multinational pharmaceutical company conducting ongoing analysis of patient conversations was looking for insights into how long patients went misdiagnosed before being accurately diagnosed with Crohn's disease. It then wanted to see how long patients tried different treatments before finding the right medication for their needs.
The analysis centered largely on blog and forum discussions.
This highly qualitative study started with 34,133 data points then focused on the 500+ points with enough data to construct these longitudinal journey maps.
Ultimately, the team built three comprehensive, archetypal maps, showing the five- to 15-year journeys undertaken by different types of patients who discussed their experiences online.
The maps demonstrated that expectations of how quickly patients move through the patient journey may have been understated.
Rather, it showed that patients spend much more time circling the symptoms-diagnosis-treatment paradigm before they make reasonable progress towards something the patient would consider an acceptable outcome.


A named/endowed scholarship provides a beautiful way to memorialize loved ones as it unites their names in perpetuity with Carlow University and its Mercy legacy.
As an added incentive, Barbara Capozzi Kirr '60 and her husband, David, made a generous gift to create the Capozzi Kirr Challenge that will provide a $5,000 grant to match any individual or group of individuals or organizations that would give $20,000 toward establishing a new, named endowment for $25,000.
We would be pleased to provide you with additional information and to work with you and your advisors to discuss your bequest to Carlow University.


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Stress can wreak serious havoc on our bodies, but we actually need stress to a certain extent. For example, if we were running from a bear, we would need our stress response to kick in full force. We would start breathing faster, sending more oxygen to muscles to fuel movement, then our bodies would release stress hormones from our adrenal glands (cortisol) to heighten our focus by tapping into energy reserves for fuel so we could flee the danger. Cortisol isn't always the bad guy, but when this response is high and chronic it tells your body to eat more than it "needs" because it's thinking much more about survival, not stress over a work deadline or relationship woe. Cortisol is needed, but high levels of cortisol over time will contribute to those mentioned health impacts, especially abdominal weight gain! The problem is when we're actually not in danger and our bodies are living in this state chronically. THIS is the magic piece of the puzzle – learning how we can turn off that heightened stress response when it's not needed.
No matter how busy you are, eat lunch before 3 p.m., a Spanish study suggests. Researchers placed a group of women on a diet for 20 weeks; half ate lunch before 3 and half consumed their midday meal after 3. Although both groups' daily caloric intake, time spent exercising and sleeping, and appetite hormone levels were the same, those who lunched late lost about 25 percent less weight than earlier eaters. Being European, lunch was the biggest meal of the day for these women, constituting 40 percent of their calories for the day, so consider slimming down dinner in addition to watching the clock.
Calcium: For adult women aged 19-50, the USDA recommended daily allowance is 1,000 mg/day. For women over 50, the recommended daily allowance is 1,200 mg/day. Good sources of calcium include dairy products, leafy green vegetables, certain fish, grains, tofu, cabbage, and summer squash. Your body cannot take in more than 500 mg at any one time and there's no benefit to exceeding the recommended daily amount.
"The reason most people don't see changes isn't because they don't work hard—it's because they don't make their workouts harder," says Adam Bornstein, founder of Born Fitness. His suggestion: Create a challenge every time you exercise. "Use a little more weight, rest five to 10 seconds less between sets, add a few more reps, or do another set. Incorporating these small variations into your routine is a recipe for change," he says.
Women who are socially marginalized are more likely to die at younger ages than women who are not.[21] Women who have substance abuse disorders, who are homeless, who are sex workers, and/or who are imprisoned have significantly shorter lives than other women.[21] At any given age, women in these overlapping, stigmatized groups are approximately 10 to 13 times more likely to die than typical women of the same age.[21]
Women who seek out a women's only club are usually looking for something different. They want the privacy of an all-women environment. They also want the attention they get from women who understand the unique fitness needs of other women and are especially patient and understanding with those who haven't had much experience with fitness in their lives.
Our women's fitness programs are designed for women from the ground up. We teach from the female anatomy and physiology, the feminine psyche and include all the subtle bodies – the emotional, mental and spiritual that have an impact on the physical. We understand the different needs of the woman as she exercises through pregnancy, postnatal, menopause and the later years of her life and how these changes affect her women's fitness needs and goals.
We cater to every fitness need — and you'll find everything from cardio equipment and strength training — to small group training classes like Tribe and youth fitness programs. Burn calories with high intensity group exercise, cycling or circuit training workouts, or enjoy the low impact mindfulness of our many yoga classes, hot yoga and Pilates. Amenities also include private locker room facilities with dry saunas and onsite childcare.
Getting enough water also is important. Many experts recommend at least eight 8-ounce glasses of water daily—more if you exercise frequently or are exposed to extremes of heat and cold. The 2010 Dietary Guidelines for Americans emphasize drinking more water and other calorie-free beverages, along with fat-free or low-fat milk and 100 percent fruit juices, instead of calorie-packed regular sodas.
The Center for Young Women's Health (CYWH) is a collaboration between the Division of Adolescent and Young Adult Medicine and the Division of Gynecology at Boston Children's Hospital. The Center is an educational entity that exists to provide teen girls and young women with carefully researched health information, health education programs, and conferences.
Rocking out to your fave playlist helps you power through a grueling workout, and now research shows singing, humming, or whistling may be just as beneficial. [Tweet this tip!] A German and Belgian study found that making music—and not just listening to it—could impact exercise performance. People who worked out on machines designed to create music based on their efforts exerted more energy (and didn't even know it) compared to others who used traditional equipment. Sweating to your own tune may help make physical activities less exhausting, researchers say.
At Women's Fitness Company, we strive everyday to support and empower women to change their lives through fitness and education. We do this by focusing on relationships with you, our member and by providing the highest quality of service and the most knowledgeable staff in the valley. You do not have to feel alone in reaching your fitness goals because everything we do starts and ends with you!
Third, of the interventions that were evaluated, many interventions targeted women who were pregnant, lactating, or with young children <5 y of age. We do not refute the important focus on mothers and their children as a group deserving of special attention, given women's increased nutrient needs during pregnancy and lactation and the intergenerational consequences during this period. However, even the interventions that focused on maternal nutrition often only reported on birth and nutrition outcomes of the child, and not those of the mother. In addition, although there were interventions that targeted adolescent girls and women of reproductive age, they were fewer and less well evaluated than interventions that targeted women as mothers. This aligns with findings from other research which illustrated a higher proportion of programs targeting pregnant and lactating women and women with young children (209). We also found major gaps in the targeting of interventions for older women. With growing rates of overweight, obesity, and noncommunicable diseases, in addition to undernutrition and micronutrient deficiencies, it is essential to think outside of the maternal-focused paradigm to reach women at all life stages.
Calories. Most times, women need fewer calories. That's because women naturally have less muscle, more body fat, and are usually smaller. On average, adult women need between 1,600 and 2,400 calories a day. Women who are more physically active may need more calories. Find out how many calories you need each day, based on your age, height, weight, and activity level.
Three related targets of MDG5 were adolescent birth rate, contraceptive prevalence and unmet need for family planning (where prevalence+unmet need = total need), which were monitored by the Population Division of the UN Department of Economic and Social Affairs.[64] Contraceptive use was part of Goal 5B (universal access to reproductive health), as Indicator 5.3.[65] The evaluation of MDG5 in 2015 showed that amongst couples usage had increased worldwide from 55% to 64%. with one of the largest increases in Subsaharan Africa (13 to 28%). The corollary, unmet need, declined slightly worldwide (15 to 12%).[37] In 2015 these targets became part of SDG5 (gender equality and empowerment) under Target 5.6: Ensure universal access to sexual and reproductive health and reproductive rights, where Indicator 5.6.1 is the proportion of women aged 15–49 years who make their own informed decisions regarding sexual relations, contraceptive use and reproductive health care (p. 31).[66]
WASH interventions, such as toilet facilities, access to improved and safe water supply, and hand washing are associated with improved nutrition and health of entire communities (13, 14, 125–128). For women and adolescent girls, WASH interventions were associated with improved menstrual hygiene (126), reduced diarrhea and intestinal worm infections (128–131), and reduced maternal mortality (132). Women and young girls are also more affected by the physical and time burdens of collecting water (126), and harassment and violence associated with inadequate and unsafe toilet facilities (133, 134). Closer water points and sanitation facilities eased these gendered burdens (126, 135). WASH interventions and perceived water availability were associated with less time spent on water-related chores, and improved school attendance, women's empowerment, and self-esteem (126, 135, 136).
It has affected more than 200 million women and girls who are alive today. The practice is concentrated in some 30 countries in Africa, the Middle East and Asia.[77] FGC affects many religious faiths, nationalities, and socioeconomic classes and is highly controversial. The main arguments advanced to justify FGC are hygiene, fertility, the preservation of chastity, an important rite of passage, marriageability and enhanced sexual pleasure of male partners.[11] The amount of tissue removed varies considerably, leading the WHO and other bodies to classify FGC into four types. These range from the partial or total removal of the clitoris with or without the prepuce (clitoridectomy) in Type I, to the additional removal of the labia minora, with or without excision of the labia majora (Type II) to narrowing of the vaginal orifice (introitus) with the creation of a covering seal by suturing the remaining labial tissue over the urethra and introitus, with or without excision of the clitoris (infibulation). In this type a small opening is created to allow urine and menstrual blood to be discharged. Type 4 involves all other procedures, usually relatively minor alterations such as piercing.[78]
To help you learn how to eat healthfully, start with the U.S. Department of Agriculture's (USDA) dietary guidelines system, which you can find at http://www.mypyramid.gov. The MyPyramid system, which looks somewhat like the familiar food pyramid of old, offers guidance based on individual needs and replaces "serving" recommendations with actual amounts of food. It also emphasizes the importance of balancing nutritious (and tasty!) food choices from all food groups every day with daily physical activity.
Internationally, many United Nations agencies such as the World Health Organization (WHO), United Nations Population Fund (UNFPA)[171] and UNICEF[172] maintain specific programs on women's health, or maternal, sexual and reproductive health.[1][173] In addition the United Nations global goals address many issues related to women's health, both directly and indirectly. These include the 2000 Millennium Development Goals (MDG)[142][43] and their successor, the Sustainable Development Goals adopted in September 2015,[47] following the report on progress towards the MDGs (The Millennium Development Goals Report 2015).[174][37] For instance the eight MDG goals, eradicating extreme poverty and hunger, achieving universal primary education, promoting gender equality and empowering women, reducing child mortality rates, improving maternal health, combating HIV/AIDS malaria and other diseases, ensuring environmental sustainability, and developing a global partnership for development, all impact on women's health,[43][11] as do all seventeen SDG goals,[47] in addition to the specific SDG5: Achieve gender equality and empower all women and girls.[109][175]
Trimming some fat may eliminate some guilt, but be warned: Buying foods labeled "low-fat," "non-fat," or "fat-free" may encourage you to eat up to 50 percent more calories, according to three studies by Cornell University's Food and Brand Lab. Fat's not the issue when it comes your weight since most of these foods only have about 15 percent fewer calories than their regular counterparts. Go for the full-fat version and eat less—you probably will naturally since they taste better.
Most experts recommend 1,300 mg of calcium a day for girls aged 9 through 19. Natural sources of calcium, such as low-fat dairy products, are the smartest choice, because they also contain vitamin D and protein, both required for calcium absorption. Milk, yogurt, and cheese contribute most of the calcium in our diets. Some vegetables are also good sources, including broccoli, kale, and Chinese cabbage. Many foods are supplemented with calcium, including some brands of orange juice and tofu. The daily intake for Vitamin D is 600 IU per day for most children and healthy adults.
It's a cliché, to be sure, but a balanced diet is the key to good nutrition and good health. Following that diet, however, isn't always that easy. One challenge is that women often feel too busy to eat healthfully, and it's often easier to pick up fast food than to prepare a healthy meal at home. But fast food is usually high in fat and calories and low in other nutrients, which can seriously affect your health. At the other extreme, a multimillion dollar industry is focused on telling women that being fit means being thin and that dieting is part of good nutrition.
Having the proper footwear is essential for any workout, and for winter runs, that means sneaks with EVA (ethylene vinyl acetate), says Polly de Mille, an exercise physiologist who oversees New York Road Runner's Learning Series for first-time New York City Marathon runners. "Polyurethane tends to get really stiff and cold in the winter, which could increase your risk of injury." Another important feature is a waterproof and windproof upper: Look for shoes made with Gortex, or wrap your mesh uppers in duct tape to keep feet dry and warm.
Part of the reason why so many women fail to get the amount of iron they need is because one of the best sources of iron is red meat (especially liver) which also contains high levels of saturated fat. While leafy green vegetables and beans are also good sources of iron—and don't contain high levels saturated fat—the iron from plant foods is different to the iron from animal sources, and not absorbed as well by the body. Other foods rich in iron include poultry, seafood, dried fruit such as raisins and apricots, and iron-fortified cereals, breads, and pastas.
Nutritionists recommend choosing a rainbow of fruits and vegetables because each one provides a unique blend of nutrients. Within the color spectrum, yellow or orange veggies are great sources of vitamin A for skin and eye health and better immunity against infection. At the top of the list are carrots, sweet potatoes, pumpkin, and the many types of squash. While it takes just one whole carrot or six baby carrots to make one serving (one-half cup), you'll need only half a starchy sweet potato.
I subscribed to this in MY early 20's way back in the magazines infancy. Back when the cover photo's were black and white and most of the cover "models" were female athletes. It's changed since then, catering a little more to the "Cosmo" crowd. Which is fine, just not for me. It just doesn't feel like it applies as much to someone in their thirties married with kids as someone in their twenties who apparently has the money and lack of self-control to spend $90 on a designer t-shirt (really).
WASH interventions were typically community-based. WASH interventions were delivered to households and communities through community mobilization, mass media, home visits, and infrastructural development (126, 130, 136–138). There were some examples of facility-based delivery of WASH interventions, such as in health clinics and schools (139, 140); however, this was not representative of the majority of delivery platform coverage. Health clinic delivery platforms had limited reach, often targeting pregnant women and women with young children. In an evaluation of WASH interventions delivered in India (141), more demanding behavioral practices, such as handwashing and consistent use of latrines, required more intense contact (e.g., multiple home visits) than less intense interventions, such as sweeping of courtyards, that could be effectively delivered in small group meetings such as those in health clinics and community centers. More research is needed to evaluate the benefits and barriers of different delivery platforms for women across the life course.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
If you usually head to the gym after work, take heed: Mental exhaustion can make you feel physically exhausted, even when you have plenty of energy, reports a Medicine & Science in Sports & Exercise study. When people played a brain-draining computer game before exercising, they reported a subsequent workout as being harder, yet their muscles showed the same activity as they did doing the same workout after an easy mental game. So if you think you can't eke out those last 10 minutes on the rowing machine, remember: You can! [Tweet this motivation!]
Family planning and birth spacing can influence the nutrition of adolescent girls, women of reproductive age, and women with young children by reducing the number of adverse outcomes associated with pregnancy and abortion. For adolescent girls, in particular, pregnancy is associated with increased risk of birth complications, anemia, hindered linear growth, and loss of educational attainment (8, 107). Delaying early child marriages and providing access to family planning, particularly for young wives, allow girls to achieve their maximum growth potential (8, 142). However, for women with young children, there was scarce evidence from observational studies to suggest that greater birth spacing had any impact on anthropometric status (BMI, weight), micronutrient status (anemia, as well as serum zinc, copper, magnesium, and folate), and maternal mortality outcomes (13, 107, 143–147). Findings were mixed, which was attributed to sample size and other confounding factors such as maternal age, breastfeeding status, and supplementation status (146, 147). The strongest evidence of the impact of birth spacing on women's nutrition was related to increased risk of preterm delivery and maternal anemia in interpregnancy intervals <6 mo (14, 146, 147) and increased risk of pre-eclampsia in intervals >5 y (107).
Women, as we age, are also more susceptible to the breakdown of our bones, which may result in osteoporosis over time. Genetically, women have a particularly high risk of osteoporosis compared to men, so it's recommended that women monitor their calcium intake to be sure they're getting enough. Weight training is another great way (and my favorite!) to build bone density, which is another great reason you should hit the weights!
There are many well-documented challenges in disentangling empowerment interventions from other interventions with which they are delivered. Empowerment interventions are often integrated into income-generating activities and agricultural extension, and many empowerment approaches are retroactively classified as "nutrition-sensitive" despite a lack of nutrition components in the original intervention designs (5). In addition, many studies are limited in scope and their evaluation of nutrition outcomes (159), and it is difficult to evaluate which dimensions of women's empowerment matter most for nutrition (162). Notably, indicators to quantify women's empowerment are also not used consistently and vary widely between individual studies (158).
In 2013 about 289,000 women (800 per day) in the world died due to pregnancy-related causes, with large differences between developed and developing countries.[11][37] Maternal mortality in western nations had been steadily falling, and forms the subject of annual reports and reviews.[38] Yet, between 1987 and 2011, maternal mortality in the United States rose from 7.2 to 17.8 deaths per 100,000 live births, this is reflected in the Maternal Mortality Ratio (MMR).[38] By contrast rates as high as 1,000 per birth are reported in the rest of the world,[11] with the highest rates in Sub-Saharan Africa and South Asia, which account for 86% of such deaths.[39][37] These deaths are rarely investigated, yet the World Health Organization considers that 99% of these deaths, the majority of which occur within 24 hours of childbirth, are preventable if the appropriate infrastructure, training, and facilities were in place.[40][37] In these resource-poor countries, maternal health is further eroded by poverty and adverse economic factors which impact the roads, health care facilities, equipment and supplies in addition to limited skilled personnel. Other problems include cultural attitudes towards sexuality, contraception, child marriage, home birth and the ability to recognise medical emergencies. The direct causes of these maternal deaths are hemorrhage, eclampsia, obstructed labor, sepsis and unskilled abortion. In addition malaria and AIDS complicate pregnancy. In the period 2003–2009 hemorrhage was the leading cause of death, accounting for 27% of deaths in developing countries and 16% in developed countries.[41][42]
Even if you are the most independent exerciser around, give a group fitness class a shot at least once a week—you may find that you enjoy it more than sweating solo. "Happiness and health are shared through social connectedness and closeness," says Greg Chertok, director of sport psychology at the Physical Medicine and Rehabilitation Center in New Jersey. "Geography and proximity are predictors of how contagious emotions can be, and this may translate into an athletic environment too." Sign up for Bikram, CrossFit, spin, or Zumba, and you could find yourself—gasp!—smiling at the gym thanks to your classmates.

redpajama_set_name: RedPajamaCommonCrawl


text:
Adrian Grenier, Jerry Ferrara, Kevin Connolly, Jeremy Piven and Kevin Dillon in a scene from the movie Entourage. Claudette Barius
Entourage cast and creatives keen to make another movie
by scronin
12th Jun 2015 7:00 AM
ENTOURAGE has topped the Australian box office, knocking disaster movie San Andreas off its perch.
The film earned $3.4 million in its opening weekend. It is based on the hit, eight-season HBO series of the same name, which is loosely based on producer Mark Wahlberg's experiences coming up in Hollywood.
Another film could be in the works, actor Kevin Dillon told APN.
"What could be next for us, if people go see the movie, is there could be another Entourage movie," he said.
"We've all talked about it; I know the guys will do it. Doug Ellin (the writer and director) will write, it, so there's a good chance."
The film follows movie star Vincent Chase (Adrian Grenier) as he attempts to direct his first film after securing money from his agent, and now studio executive, Ari Gold (Jeremy Piven).
Vincent casts his older half-brother Johnny Drama (Dillon), who finally has a shot at receiving recognition for his acting talents when he is nominated for a Golden Globe.
Entourage stars play 'Never have I ever' with Ellen
Entourage: The boys are back ... and as sexist as ever
'Entourage' cameo for Pattinson
Minions movie: evolution that's full of beans
entourage mark wahlberg
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text:
Pierre Alain Guertin est un neuroscientifique canadien né le  à Montréal au Québec. Il est professeur titulaire retraité au département de psychiatrie et neurosciences à l'Université Laval, directeur de recherche au CHU de Québec (2001-2020) et dirigeant de sociétés dans le secteur pharmaceutique.

Résumé biographique
Étudiant à l'Université de Montréal en kinésiologie, il obtient ensuite une bourse à l'Université du Québec à Montréal afin de poursuivre son apprentissage à la maîtrise en physiologie du contrôle moteur, à Montréal au Québec. Il y est initié à la neurophysiologie et à l'importance des réseaux de neurones de la moelle épinière par le Dr. Réjean Dubuc.
Mais c'est à l'Université du Manitoba dans l'ouest canadien qu'il obtient son doctorat en physiologie-neurophysiologie avant de suivre des formations spécialisées de chercheur postdoctoral à Copenhague, à Oxford, et à Marseille.

En 2001, il entreprendra sa carrière de directeur de recherche à l'Université Laval, à Québec. Quatre ans plus tard, en 2005, il découvre et fait breveter Spinalon (buspirone/l-dopa/carbidopa) alors qu'il fonde sa première société dérivée, Neurospina Thérapeutiques, afin d'en assurer le développement préclinique et clinique .

Il reçoit plusieurs prix, honneurs et distinctions pour la découverte de Spinalon dont le Seau d'Excellence de la Commission Européenne en 2020 et le prix Bio-Innovation du CQVB remis en 2006 par Raymond Bachand, ministre du Développement économique, de l'Innovation et de l'Exportation du Québec à l'époque. Une autre de ses découvertes, nommée Micselon, fut classée au premier rang en 2012 par les Instituts de Recherche en Santé du Canada (CIHR-IRSC) dans le cadre du concours national sur le transfert technologique en santé .

Travaux
Le Dr. Guertin travaille principalement sur les problèmes chroniques de santé secondaires liés à une lésion de la moelle épinière. Grâce à une approche comparable au criblage à haut débit (high-throughput screening en anglais) utilisée généralement par l'industrie pharmaceutique, il développe une nouvelle version pour des analyses comportementales quantitatives et parvient à identifier des substances chimiques capables d'activer in vivo certains neurones de la moelle épinière lombaire chez des sujets (animaux ou humains) atteints de paraplégie . Il réussit notamment, quelques minutes après l'administration de sa première découverte, Spinalon, à rétablir chez ces sujets une activité locomotrice de base. Administré plusieurs fois par semaine, il démontre aussi que ce traitement permet de prévenir le développement de problèmes chroniques de santé telles que la sarcopénie, l'anémie, et la décalcification osseuse.

Il s'intéresse aussi à d'autres problèmes de santé chroniques liés au vieillissement, à des problèmes du métabolisme et d'ordre vasculaire, ou à l'immobilité chronique de même qu'aux problèmes de cardiotoxicité induits par la chimiothérapie répétée chez des patients souffrant de cancer.

Il étudie certains problèmes liés à la psychologie et à la psychiatrie grâce à ses travaux sur les fondements neurobiologiques de comportements réflexes ou involontaires et sur la sentience et les comportements considérés comme étant issus de la conscience.

Œuvres et publications

  «The spinal cord: functional organization, diseases, and dysfunctions», in: Animal Models of Spinal Cord Repair, Humana Press, Springer Protocols, vol 76, (2013): 1-123.
  Steuer I., Guertin, P.A. 2019. «Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences». Reviews in Neurosciences; 30(2): 107-164.
  Guertin, P.A. 2009. «The mammalian central pattern generator for locomotion». Brain Research Reviews 62: 45-56.
  Guertin, P.A., Ung, R.V., and Rouleau, P. 2010. «Oral administration of a novel tri-therapy for central pattern generator activation in paraplegic mice: Proof-of-concept of efficacy». Biotechnology Journal 5: 421-6.
  Guertin, P.A., Ung, R.V., Rouleau, P., and  Steuer, I. 2011. «Effects on locomotion, muscle, bone and blood induced by a combination therapy eliciting weight-bearing stepping in non-assisted spinal cord-transected mice». Neurorehabilitation and Neural Repair 25: 234-42.
  Guertin, P.A. 2005. «Composition and method of a treatment for inducting body locomotor movements», international PCT patent application, PCT/CA2005/001337.
  Guertin, P.A. 2015. «Methods and uses for inducing or facilitating micturition in a patient in need thereof», US provisional patent application, US61/946,097.
 .
  Guertin, P.A. 2019. «Medicines to enhance self-consciousness, mindfulness and healthy ageing?» Gerontology & Geriatrics Studies 4(3): 1-3.
  Guertin, P.A. 2017. «Cancer therapy-induced cardiotoxicity: Were are we now.» Cardiology and Cardiovascular Medicine 1(2): 102-109.

Honneurs et hommages
 1994 - Bourse d'excellence, Rick Hansen Foundation
 1995 - Bourse d'excellence, Rick Hansen Foundation
 1996 - Bourse d'excellence, Rick Hansen Foundation
 1997 - Bourse d'excellence, Rick Hansen Foundation
 1998 - Bourse d'excellence, Rick Hansen Foundation
 2000 - Bourse d'excellence, Human Frontier Science Program
 2004 - Bourse Chercheur Junior I Centre, Fond de la Recherche en Santé du Québec
 2005 - Bourse Chercheur Junior II, Fond de la Recherche en Santé du Québec
 2006 - Prix Bio-Innovation, Centre Québécois de Valorisation des Biotechnologies
 2008 - Bourse Chercheur Senior, Fond de la Recherche en Santé du Québec
 2013 - Prix du Lauréat de Québec, Le Soleil-Radio-Canada
 2014 - Prix du Lauréat Hommage aux chercheurs-inventeurs, Université Laval
 2016 - Prix du Lauréat Hommage aux chercheurs-inventeurs, Université Laval

Notes et références

Voir aussi

Articles connexes

 Minassian K, Hofstoetter US, Dzeladini F, Guertin PA, Ijspeert A. T. The Human Central Pattern Generator for Locomotion: Does It Exist and Contribute to Walking?
 Hofstoetter US, Knikou M, Guertin, PA, Minassian K. Probing the Human Spinal Locomotor Circuits by Phasic Step-Induced Feedback and by Tonic Electrical and Pharmacological Neuromodulation
 Braumann S, Baldus S, Pfister R. Molecular mechanisms underlying cardiotoxicity of novel cancer therapeutics.
 Frith CD. The neural basis of consciousness

Liens externes

 Linkedin
 CHUQ
 Université Laval
 Radio-Canada
 CBC breakaway
 Spinal cord research advocacy
 Pharmabio
 Worldwidescience
 Médecine Sciences
 Clinicaltrials
 Groupe de Neurophysiologie
 Dimensions

Professeur québécois

Professeur à l'Université Laval

redpajama_set_name: RedPajamaWikipedia


Brian T. Lenell is licensed to sell securities in Wyoming, Colorado, Kansas, Nebraska, Utah and Illinois, and licensed to sell life and health insurance in Wyoming, Colorado and Illinois. Investment advisory services offered through O.N. Investment Management Company. Securities offered through The O.N. Equity Sales Company, Member FINRA/SIPC, One Financial Way, Cincinnati, Ohio 45242 (513) 794-6794.


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Gujarat Elections
Rajkot News
Tug drowns after explosion in engine, three missing
TNN | Dec 22, 2018, 8:53 IST
The tug was carrying local customs department officials and employees of a shipping agency.
RAJKOT: Four crew members were seriously injured while three others are missing after a massive mid-sea explosion in the engine of tug named 'Varun' near Gogha on Friday.
The accident happened 10 nautical miles off Ghogha coast near Piram Island. T he tug was carrying local customs department officials and employees of a shipping agency who had gone to inspect a vessel named MV Paul which had come for breaking at Alang shipyard.
Minutes after the officials boarded MV Paul, there was an explosion in the tug, which drowned in less than two minutes.
Bhavnagar superintendent of police Pravin Mal told TOI: "As per available information, there was a leakage in the diesel pipe of the tug, which could have led to the fire.. Four persons were rescued and they are under treatment and out of danger. Search is on for three other crew members."
Of the four rescued, one was pulled out from the rug by throwing a tyre while a boat of Ghogha Marine police station, which was in patrolling near-by, immediately reached there and rescued three others, said Mal.
The boats of Gujarat Maritime Board (GMB) and Ghogha Marine police station were immediately dispatched for rescue operation. The operation is being aided by the Indian Coast Guard and special operations group (SOG) too.
One of the injured was identified as 32-year-old Abu Jar Mandal. The names of the missing persons and other three injured were not known till the time of going to press as the entire staff was busy in rescue operations. The injured are under treatment at Sir T Hospital in Bhavnagar.
Primary application registered with Ghogha Marine police station stated that the incident took place when the tug reached near Piram Island and the boat's engine exploded. She drowned in just about one-and-a-half minute.
According to source, fire had broke out in the same tug in March too.


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The Lavon Affair: How a false-flag operation led to war and the Israeli bomb
By Leonard Weiss | July 1, 2013
The Lavon Affair, a failed Israeli covert operation directed against Egypt in 1954, triggered a chain of events that have had profound consequences for power relationships in the Middle East; the affair's effects still reverberate today. Those events included a public trial and conviction of eight Egyptian Jews who carried out the covert operation, two of whom were subsequently executed; a retaliatory military incursion by Israel into Gaza that killed 39 Egyptians; a subsequent Egyptian–Soviet arms deal that angered American and British leaders, who then withdrew previously pledged support for the building of the Aswan Dam; the announced nationalization of the Suez Canal by Nasser in retaliation for the withdrawn support; and the subsequent failed invasion of Egypt by Israel, France, and Britain in an attempt to topple Nasser. In the wake of that failed invasion, France expanded and accelerated its ongoing nuclear cooperation with Israel, which eventually enabled the Jewish state to build nuclear weapons.
Issue: Bulletin of the Atomic Scientists – Volume 69 Issue 4
Keywords: Egypt, France, Israel, Lavon Affair, Suez crisis, nuclear, sabotage
Leonard Weiss
Leonard Weiss is a visiting scholar at Stanford University's Center for International Security and Cooperation and a member of the National... Read More
James Hansen: Taking heat for decades
By Bulletin Staff
The dimensions of contemporary war and violence: How to reclaim humanity from a continuing revolution in the technology of killing
By Robert Jay Lifton
Elephant in the room: How OPEC sets oil prices and limits carbon emissions
By Alfred Cavallo
Meeting the world's energy needs entirely with wind, water, and solar power
By Mark A. Delucchi, Mark Z. Jacobson
Dragons, mules, and honeybees: Barriers, carriers, and unwitting enablers of climate change action
By Robert Gifford
Getting serious about the new realities of global climate change
By Jennifer A. Burney, Charles F. Kennel, David G. Victor


This performance was realised with Andrzej Dłużniewski's supervision on his intermedia class in 2008. In this work I show my memories from childhood and also ask the question how metamorphosis evokes metaphor. Documentation: Magdalena Kowalczyk.


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Rabindranath Tagore Nagar or simply R. T. Nagar is an area in Bangalore, India. It is situated in the northern part of the city. It is named after Rabindranath Tagore. It is part of the Bangalore North Lok Sabha Constituency and the Hebbal Assembly Constituency. R.T Nagar has two blocks, Block I and Block II. It became popular after the construction of the new airport at Devanahalli (Kempegowda International Airport)

Originally a tiny layout built by Bangalore Development Authority (BDA) in the 1970s and was surrounded by villages like Gangenhalli on the west, the military campus on the east, Matadahalli by south and parts of Hebbal village by north. But close proximity to other high-profile areas like Sadashivnagar and Dollar's colony (SanjayNagar) led to rapid development of RT Nagar. Also setting up of a Head post office on RT Nagar main road provided further impetus to the growth of RT Nagar. It is one of the posh areas in Bangalore.

Over the last few years RT Nagar has come to commonly represent many areas like MLA Layout, Gangenhalli (Ganganagar), Dinnur, SultanPalya, Kanakanagar, Manoranpalya and even Kavalabyrasandra simply because these areas fall under the RT Nagar head post office ( with Pin code 560032) jurisdiction. Even today many businesses in these areas actually show "RT Nagar post" as an address line item.

Notable natives and residents
S. R. Bommai  – Chief Minister, Karnataka, August 1988 – April 1989
Late R. Gundu Rao – Chief Minister, Karnataka, 1980 to 1983. His Son Dinesh Gundu Rao is a sitting MLA
Late Dharam Singh – Chief Minister, Karnataka, 2003 to 2006.
Veerappa Moily – Chief Minister, Karnataka, 1992–1994, former union law and petroleum and natural gas department minister
D.B. Chandre Gowda – Member of Parliament, Bangalore North Constituency

Commercial hubs

Major commercials hubs for businesses in RT Nagar are the RT Nagar Main Road (80 Ft road), Dinnur Main Road, Sultan Palya Main Road and Ganganagar 5th Main (with a sizable number of Marwari shops). Most of the commercial activities of the area are centered on the 80 Ft Main road. There are many more commercial shops in the RT Nagar Main road which includes many food buildings and shopping buildings.

Educational institutions

R.T.Nagar has many schools and pre-university Colleges, affiliated to CBSE/ISCE and the Karnataka State Board. Educational institutions include:
 Shaheen's Falcon PU College
 Williams International College
 Trillium Public School
 Modern Public English School
 Indian Public School
 Sri Rajiv Gandhi College of Dental Sciences and Hospital
 Rajiv Gandhi Institute of Technology
 Kamala College of Nursing
 Sanjay Gandhi College of Education
 Florence Public School
 Mac Nay Doon's English School
 Adarsha Vidyalaya School
 Presidency School
 Navodaya Vidyaniketana
 St. Michael's School
 Vijaya Bharati Public School
 St. George's School
 Mamatha School
 Sri Vani School
 Newton Public School
 Adarsha Polytechnic
 R.T. Nagar Public School
 Mona Education Society
 Sidhartha School and College
 Everest Public school
 Kuppuaraju English school
 Sumangali Seva Ashram
 Hebbal Government School
 R.T Nagar Government High School
 Bright Kid Montessorie
 Kamala Girls High School
 Presidential School
 Narayana e-Techno School
 Matha school

Reference List

Geography of Bangalore
Memorials to Rabindranath Tagore
Neighbourhoods in Bangalore


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The Zanzibar Collection is comprised of four, award-winning hotels and resorts that are family owned and operated. They are the pioneers of luxury travel on the South Eastern coast of Zanzibar and The Zanzibar Collection was the first hospitality company to establish itself on this part of the island over 20 years' ago. Since The Zanzibar Collection was founded, its owners have dedicated themselves to improving the lives and the environment that surround its properties, based on the three pillars of sustainable tourism: economic, social and environmental responsibility.
THE ZANZIBAR COLLECTION'S COMMITMENT to SOCIAL RESPONSIBILITY
As a family-founded and run business we are committed to exceeding rather than meeting our social responsibility. Thus, we employ local people wherever possible and we invest generously in skills-set provision and community welfare. We're proud to divulge the fact that most of our managers have worked their way up through the ranks. Moreover, we've supported them via an innovative training programme that has ensured them a life-long career in the tourism industry. We're also devoted to the substantial support of our local community in terms of health, sanitation and educational infrastructure. Similarly, we purchase fresh produce from the local farmers and fishermen wherever possible.
We support local craftsmen and artisans in our interior design and refurbishment as well as marketing our own range of Palacina Interior Design, much of which is produced in Zanzibar. Our unwavering commitment to the use of solar power, energy-saving, minimal plastics use, organic gardening, general waste and water recycling and marine environmental protection has also ensured that our green-planet credentials are first class. Finally, as the first tourism operatives to install electricity in this area we have made a substantial contribution to its development in terms of transport, employment, income and overall infrastructure.
WELFARE AND CSR RESPONSIBILITY
Breezes Beach Club and Spa was the first hotel in The Zanzibar Collection to be built. From the outset, the Zanzibar Collection decided to employ local people to work in the hotel and to date, 90% of the workforce throughout the entire Zanzibar Collection of hotels come from the local villages – from Zanzibar and Tanzania. Employment opportunities are always offered first to those living in the area.
The Zanzibar Collection has invested heavily in skills development and career management for their staff, through mentoring and training. Many middle and senior managers started their careers in entry-level positions and have been given ample assistance to develop their potential and achieve their goals. The Manager at The Palms started off as a waiter at Breezes Beach Club, Resort & Spa!
The Zanzibar Collection is heavily involved with the local community and its support has led to the building of a Maternity and Neo Natal Clinic in the local village and it also provides much needed medical supplies. The Zanzibar Collection actively encourages its guests to visit the local village of Bwejuu and discover how it supports the community through education, healthcare and clean water.
ENERGY EFFICIENCY AND REDUCTION
The Zanzibar Collection was the first to bring electricity to this area of the island. Through their persistence, the introduction of electricity changed this area enormously as it allowed the developments of roads and overall infrastructure, which lead to consistent employment and income.
Baraza Resort and Spa and Breezes Beach Club and spa use solar water heating systems. This minimises the carbon footprint of The Zanzibar Collection.
The Zanzibar Collection encourages its guest to turn off the air-conditioning when not in the bedrooms, to reduce the amount of energy usage.
The Zanzibar Collection features a state of the art sewage treatment plant, where black and grey waters are recycled and used for irrigation. All the massive gardens of Zawadi were planted using a natural product which absorbs humidity during the day and releases it into the roots at night, this allowed Zawadi to save 50% of all water needs for irrigation. In addition, to reduce the amount of water used, The Zanzibar Collection has implemented water saving initiatives, which include the reuse of linen and towels as well as the installation of low-flow faucets and showerheads.
TARGET – ZERO PLASTIC USE
As a group, we believe in the eradication of single-use plastic wherever possible and have replaced it with recyclable cardboard and paper for all our catering needs. We're also committed to the use of glass bottles rather than plastic; whilst providing drinking-water for re-usable containers in all our units. You may also like to know that any single-use plastic containers that are still in use are immediately recycled either into plant pots or into construction materials.
LOCALLY SOURCED DÉCOR AND INTERIORS
Many of the artefacts and beautiful furniture that is seen in the hotels across The Zanzibar Collection are handcrafted by local craftsmen and women celebrating traditions and skills that have been passed from generation to generation. Sourcing items locally rather than from abroad, provides much-needed income to the local community. Many items are reclaimed, adhering to the policies of reduce, reuse, recycle rather than purchasing new.
SUSTAINABLE FOOD OPTIONS
Where ever possible The Zanzibar Collection sources its menu items direct from local suppliers; this aids the local economy. The organic garden at Zawadi Hotel provides this property with a range of fresh fruits and vegetables and the fish served is always purchased from local fishermen.
By eating locally and seasonally, the fruits and vegetables served in the hotels are diverse. This also reduces air miles on some items. By using local produce, this has led to a to more sustainable and healthier offering to its guests and creates opportunities for them to experience a greater connection to the area through the provision of local dishes.
In addition, the use of locally sourced produce means it is often organic and hasn't been treated with pesticides or hormones, which provides guests of the Zanzibar Collection with healthier food selections.
SUSTAINABLE SANITATION
We have invested in our own state-of-the-art sewage-treatment plant, which turns both black and grey water into irrigation water.
We plant only indigenous species in our grounds, and they are chosen for their ability to absorb humidity during the day and release it into the roots at night – thus delivering a 50% reduction in uptake of precious water. We also adhere to a stringent policy of laundry/bathroom water-use minimization.
ACTIVITIES WITH A CONSCIENCE
Guests are encouraged to take part in educational tours to discover the coral reefs in the area and see first-hand the diverse ecosystems that exist.
The local culture is important and provides guests with an understanding of the area. The Zanzibar Collection encourages guests to experience the diverse past of Zanzibar and can arrange tours to the UNESCO World Heritage Site of Stone Town, as well as on-site Swahili cookery classes and the art of palm weaving. Tours to the Jozani Forest, home of the rare red colobus monkey can be organised, in small intimate groups. All of these activities contribute to the local economy and provide much-needed funds to preserve and protect these areas whilst educating guests at the same time. The Children's Program includes Swahili classes and reef walks and talks with our Marine Biologist.
MARINE CONSERVATION PROGRAM
The Zanzibar Collection employs a marine biologist specialised in conservation and tidal ecosystem, there is an educational program for all the staff members, in order to sensitize them to the importance of the ocean as a resource and how to manage it. The guests as well are welcome to join the program, they go on reef walks and are taught about the delicate balance of the tidal lagoon ecosystem.
Snorkelling the nearby reefs provide guests with invaluable insight and education into the diverse array of marine life that can be seen. By taking guests on snorkelling safaris, they can see first-hand, the assortment of aquatic life and the need to protect and preserve the oceans.
FRANGIPANI SPAS
Both Frangipani Spas at Breezes Beach Club and Spa and Baraza Resort & Spa use products that are native to the area, rather than commercially produced. This not only provides guests with a greater connection to Zanzibar itself, but also guests benefit from products that are hand-made and free of parabens, which are overall kinder to the environment and the skin.
COMMITMENT GOING FORWARDS
The Zanzibar Collection has successfully built a family owned and operated organisation which is founded on the basis of providing a conscious commitment to social, economic and environmental responsibility. It has proven that luxury, executed with a conscience, can have an immensely positive impact and will continue to develop its policies to ensure the protection and preservation of our planet.
GREEN, THE COLOUR OF OUR INTERIOR DESIGN
The distinctive art and furniture that so define our style are hand-made by local artisans. In this way we both celebrate and preserve the nation's heritage for future generations whilst providing an invaluable income for our local community. We also excel in creating our distinctive 'look' whilst also using upcycled locally sourced/reclaimed materials.
Our chefs and managers purchase locally wherever feasible. In this way they support a wide range of local farmers, fishermen and artisans. Similarly, they insist on buying only seasonally and organically grown produce. Wherever possible, our menus reflect the authentic heritage of the region while our methods preserve local skills and customs. All our menus are planned with the reduction of airmiles in mind; and according to the most stringent nutritional standards.
ECO-CLEVER LEISURE ACTIVITIES
When it comes to leisure activities, we ensure that they accord with the principals of social responsibility and environmental protection. We are also dedicated to the preservation of the ancient heritage of the island by means of our classes in cookery, palm-weaving, Swahili and Bao. Our guest library also celebrates the rich cultural heritage of the archipelago while our policy of support to local villages promotes their development.
CARING MARINE CONSIDERATION
Our dedicated marine biologist ensures the well-being of our tidal ecosystem. We also provide educational workshops for all our staff (which our guests are welcome to join). Similarly, we promote such ecologically-sound pursuits as reef walks, diving and snorkeling.
FAMILY HOLIDAYS AND HAPPY CHILDREN
We are delighted to present a family-friendly environment as well as a wide range of 'edutainment'. We can offer baby cots/chairs, additional beds for children, children's mealtimes and leisure options to include: guided reef walks, children's watersports, beach volleyball, sandcastle-building, Swahili lessons, cookery workshops, palm-weaving and palm-tree climbing for kids plus tours of the Jozani Forest, Stone Town and the Spice Plantations. We also invite our families to learn to kite surf, kayak, windsurf and dive… or simply go for a bike ride. We also provide family-oriented visits to the local village and school.
Our Frangipani Spas are run to the same ecologically impeccable lines as are every other aspect of our hotels. Our scrubs and body treatments are hand-made and use locally produced coconuts, fruits spices and fragrances. All our treatments are free of harmful chemicals.
A FUTURE THAT CARES FOR THE PLANET
We have built a thriving business on the basis of a deeply held commitment to the tenets of social, economic and environmental responsibility. We believe that 'luxury with a conscience' works. It also promotes the longevity of our planet and the well-being of our people alike. Meanwhile, throughout our future, we will remain dedicated to the adoption of only environmentally- and community-supportive polices and implementations.
Email: info@thezanzibarcollection.com
www.thezanzibarcollection.com
11 + 1?


#kings_greece #spring #kayla_itsines #travelawesome . . . 📍Hermoupolis, Syros island, Cyclades, Greece.
@stellakvr Να εισαι καλα Στέλλα!!!
Εξαιρετική λήψη ! 🔝😍👏 Καλό βράδυ Κώστα !
@fouladesigns Thank you so much dear friend!
@nektarianiniraki_ Να είσαι καλά Νεκταρία! Καλό βράδυ!
@micheleiannoni Thank you kindly dear friend! Much appreciated!


Find Social Work training courses convenient to your schedule and products to help you stay current and compliant.
Ongoing training is essential for social workers and the mental health and counseling facilities that employ them. Lorman Education Services provides a wide range of social work training opportunities that can lead to the CE credits you need to meet your state's requirement for maintaining professional certification.
We focus our Social Work training courses and products on the most recent trends, laws and regulations. Out main goal of our social worker continuing education courses are to keep you and your business or facility compliant and more importantly moving in the right direction.
Social work continuing education programs often involve attending in-person social work training seminars that require you to travel to a distant location. Instead, you can use the power of the Internet to complete our courses in your office or wherever you have Web access. This makes training more convenient, and you won't waste precious time that could otherwise be devoted to helping your clients.
Lorman offers more than 70 live online training programs per month on average, which can include topics pertaining to social work training. As with social work seminars, these programs give you real-time access to the latest, most up-to-date information concerning the topics that are most relevant to your daily job function. Our social work training courses are presented by experienced Lorman faculty members who are subject-matter experts and are among the most knowledgeable professionals in the industry.
If you're unable to attend a live training event at the appointed time, it doesn't mean you can't still access our training materials online. Many of these programs are recorded and made available on demand — just log in and view the presentation whenever your schedule permits. You can also access other training resources and materials on an around-the-clock basis, including MP3 recordings, whitepapers, articles, reports and more. With such a huge amount information always available at your fingertips, you may never need to attend social work continuing education seminars in person again!
Tailor any Lorman social work course into a convenient, in-house training program. Fulfill your organization's educational needs by bringing your social work training onsite. Taking advantage of an in-house training program allows you the flexibility to decide what and when you want to learn.
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Browse our current social work training course menu and feel free to contact us if you have questions or need more information.


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Claude Earl Griffith
Claude Earl Griffith was born on August 24, 1950, to Lester Griffith and Susie Cottrell in Junction City, AR. He passed January 1, 2022, at the age of 71 in El Dorado, AR. He was preceded in death by his wife of over 20 years, Mary Gail Marks; and his parents.
Claude was a member of Three Creeks Baptist Church. He enjoyed hunting, fishing, mowing grass and working in his garden.
Survivors include his children, Patrick (Monica), of Junction City, AR and Brandy Motes of Mountainview, AR; one brother and four sisters, Junette Martindale of El Dorado, AR, Lillian Adkins of Hope, AR, Robert Griffith (Debbie) of Junction City, AR, LaVon Kendrick (Robert) of Serepta, LA and Sue Christien (Larry) of Camden, AR; one grandchild, Samantha Richardson (Ryan) of Mountainview, AR; one great grandchild, Charles Richardson. Many nieces, nephews, relatives and friends.
The family will welcome friends for visitation on Tuesday January 4, 2022 from 5-7 pm at Young's Funeral Home. Graveside services will be held Wednesday, January 5, 2022 at 3 pm at Scotland Cemetery, with Adair Ellen officiating.
Serving as Pallbearers will be Jake Caldwell, Larry Wood, Troy "Peanut" Thurman, Curtis Caldwell, Andy Brown and Sonny Caldwell.
Condolences may be shared at www.youngsfuneralhome.com for the Griffith family.


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Liverpool Lining up Bundesliga Striker
Timo Werner becomes the second RB Leipzig player to draw the Reds' attention this season.
By Audun Manum Mar 15, 2017, 9:23pm GMT
Share All sharing options for: Liverpool Lining up Bundesliga Striker
As news of Bayern Munich's approach for favoured Jürgen Klopp target Julian Brandt began to spread on Wednesday, it was only a matter of time before a new Bundesliga attacker would be linked with Liverpool. As it turns out, that time was roughly five hours, and the rumoured target is... actually a pretty reasonable one, and one who would be a good fit for the Reds.
RB Leipzig's Timo Werner has been a BuLi regular since he was 17, racking up over 100 first team appearances for childhood club Stuttgart by the time he turned 20. He began his career as a speedy winger for Die Schwaben, but has gradually drifted centrally, culminating in his ongoing explosive season for surprise package Leipzig, where he has notched 14 goals an 4 assists in 1800 minutes, averaging a goal involvement every 100 minutes he's on the pitch, while converting at a superstar 23.6%.
This increase from his previous average of a goal involvement every 244 minutes and conversion rate of 10% mainly comes down the fact that he has been made a full-time striker in Leipzig's counter-attacking 4-4-2 system, providing him with a higher volume of quality chances, and relying less on strikes from outside the box. As such, a complete reversion to the mean seems unlikely, assuming Werner continues in a central role, and his current production might be a good indication of his long-term projection.
The German international — who has notched 3 goals in his 7 caps for Die Mannschaft — stands six feet tall, possesses excellent straight-line speed, and is genuinely two-footed, both when dribbling and lining up a shot. His past out wide makes him a versatile option, and his experience in a counter-attacking system — paired with his youthful vigour and athleticism — means he can likely slip into Klopp's favoured gegenpressing style effortlessly.
With the potential signing makes all these kinds of sense, it is only natural that there are obstacles to be found, and as with Naby Keïta, Leipzig's solid financial and competitive position are the main ones. The Red Bull-backed up-and-comers sit second in the Bundesliga, with Champions League football next season as good as guaranteed, and Werner's contract runs until 2020, putting the club under no pressure to sell. If the Reds can muster up a triple temptation of Jürgen Klopp, big bucks and a Champions League run, however, turning the player's head could be enough to push a deal through.
If Julian Brandt were to slip away, Werner would be a terrific consolation price. A twofer wouldn't go unappreciated either.


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You've heard of Confucius—but what about the minds shaping China's future?
How can so large a country be made coherent? What is its story? And how can it balance individual opportunity with collective harmony? Meet the minds who made, and are making, China
by Rana Mitter	/ May 14, 2018 / Leave a comment
The thinkers who shaped China's past—and those who will shape its future. Illustration: Nick Taylor
The minds who shaped the past Confucius Philosopher (551-479BC)
The most influential Chinese person of all time, Confucius was the moral philosopher who gave China some of its most enduring markers of identity. Confucius lived at a time when the rulers of China's small kingdoms were at constant war with one another. He advocated an alternative to force: rituals and ethical behaviour. There had to be order in society, which, for him, meant control by rulers over subjects and men over women; but he also argued that the strong also owed a duty of care to the weak. Not particularly influential in his own lifetime, Confucius gained huge status in the Han dynasty (206BC to 220AD). The Chinese state continued to draw on Confucian norms into the early 20th century, but he was sidelined and often attacked by a succession of leaders, until Hu Jintao revived his ideas at the start of the 21st century. The sage's books—often reworked as "self-help" manuals—still stack up in bookshops across the country.
Sima Qian Historian (145-86BC)
Some countries don't care that much for their history. China really does; historical analogies shape everyday conversations in boardrooms, schools and ministries. Sima Qian was not China's first historian, but he may have been its first modern one even though he lived in the first century BC. He was a court historian who wrote at the height of China's first great dynasty, the Han. He played different sources off against one another, collected oral evidence from participants in major events, and even used fiction as a source (anticipating post-modern ideas that all history is fiction, sort of). His work could get him into trouble; speaking an unwelcome truth to his emperor led to Sima Qian being castrated. But to this day, his Shi Ji (Records of the Grand Historian) stands as China's answer to Livy and Herodotus.
Li Qingzhao Poet (1084-1155)
Even today, Li Qingzhao is known as one of China's greatest poets. She lived during one of the most turbulent chapter in Chinese history—the Song dynasty of the 12th century. This gave her a life of two distinct halves. She grew up as part of China's culture of highly-regulated court bureaucracy, with a husband who was a senior official, and…
4707975835d2d55b45352b1.35010259
Rana Mitter
Rana Mitter teaches Chinese history at Oxford. His series "Chinese Characters: Chinese History in 20 Remarkable Lives" runs on Radio 4 until mid-May and remains available on iPlayer


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<?php
/*
 * This file is part of the Gisoft package.
 *
 * (c) Damian Ostraszewski
 *
 */
namespace App\CounterBundle\Repository;

use Doctrine\ORM\EntityRepository;
use App\CoreBundle\Libraries\gsEntityRepository;

/**
 * Ip2CountryRepository
 *
 * This class was generated by the Doctrine ORM. Add your own custom
 * repository methods below.
 */
class Ip2CountryRepository extends gsEntityRepository {

}

redpajama_set_name: RedPajamaGithub


text:
Q: install apc on php 5.5 I have been able to install apc on php 5.3 but recently I upgraded to
php 5.5 fpm and I cant seem to install it:
Error: Package: php-pecl-apc-3.1.9-2.el6.x86_64 (base)
           Requires: php(api) = 20090626
           Installed: php-common-5.5.27-1.el6.remi.x86_64 (@remi-php55)
               php(api) = 20121113-64
.....
.....
You could try using --skip-broken to work around the problem
 You could try running: rpm -Va --nofiles --nodigest

This is what I see. Isn't there an apc version for php 5.5 or

Thank you!

A: APC is dead and unmaintained.
No stable version exists for PHP 5.4 or greater.
As said by mark, you can use:

*

*php-opcache, for opcode cache, which is the official cache, maintained inside PHP

*php-pecl-apcu, for user data cache, which is a dropin replacement (same API) of APC.

redpajama_set_name: RedPajamaStackExchange


Abstract. Diatoms account for a large proportion of primary productivity in Antarctic coastal and continental shelf zones. Diatoms, which have been used for a long time to infer past sea surface conditions in the Southern Ocean, have recently been associated with diatom-specific biomarkers (highly branched isoprenoids, HBI). Our study is one of the few sedimentary research projects on diatom ecology and associated biomarkers in the Antarctic seasonal sea ice zone. To date, the Adélie Land region has received little attention, despite evidence for the presence of high accumulation of laminated sediment, allowing for finer climate reconstructions and sedimentary process studies. Here we provide a sequence of seasonally to annually laminated diatomaceous sediment from a 72.5cm interface core retrieved on the continental shelf off Adélie Land, covering the 1970–2010CE period. Investigations through statistical analyses of diatom communities, diatom-specific biomarkers and major element abundances document the relationships between these proxies at an unprecedented resolution. Additionally, comparison of sedimentary records to meteorological data monitored by automatic weather station and satellite derived sea ice concentrations help to refine the relationships between our proxies and environmental conditions over the last decades. Our results suggest a coupled interaction of the atmospheric and sea surface variability on sea ice seasonality, which acts as the proximal forcing of siliceous productivity at that scale.
How to cite: Campagne, P., Crosta, X., Schmidt, S., Noëlle Houssais, M., Ther, O., and Massé, G.: Sedimentary response to sea ice and atmospheric variability over the instrumental period off Adélie Land, East Antarctica, Biogeosciences, 13, 4205-4218, https://doi.org/10.5194/bg-13-4205-2016, 2016.
Diatoms and biomarkers have been recently used for palaeoclimate reconstructions in the Southern Ocean. Few sediment-based ecological studies have investigated their relationships with environmental conditions. Here, we compare high-resolution sedimentary records with meteorological data to study relationships between our proxies and recent atmospheric and sea surface changes. Our results indicate that coupled wind pattern and sea surface variability act as the proximal forcing at that scale.


And where is that barrier?
The Best Way To see What I've been Doing Recently Is To Click Here!
That barrier could have something to do with the heavy traffic that can be seen on streetview. That way the small roundabout can't gridlock.
Glad to see more parts of Ireland in the works! Hopefully more to come!
Finally! Some work on Ireland! Been waiting (im)patiently for this. And what makes me more happier is how familiar it all is! I've been through New Ross several times on the way to England, so the route to Wales is very familiar also.
There isn't usually any traffic there, though I haven't passed New Ross since July of last year.
wonderful job bricksathome that looks good and hopefully you would get cork soon i would love cork and shannon in ireland.
Ireland just keeps getting better and better! Thank you for your great ideas and future plans, and keep up the BRILLIANT work!


text:
The Cable: In New Year's message, Obama reaches out to Iran In New Year's message, Obama reache...
In New Year's message, Obama reaches out to Iran
As American audiences tuned into his appearance on the "Tonight Show with Jay Leno," President Obama tonight issued a notable video message aimed at the Iranian people and their leaders on the occasion of Nowruz, the traditional New Year's celebration in Iran and across much of Central Asia. "In this season of new beginnings I ...
By Laura Rozen
As American audiences tuned into his appearance on the "Tonight Show with Jay Leno," President Obama tonight issued a notable video message aimed at the Iranian people and their leaders on the occasion of Nowruz, the traditional New Year's celebration in Iran and across much of Central Asia.
"In this season of new beginnings I would like to speak clearly to Iran's leaders," Obama says in the English-language recording, which is subtitled in Farsi. "We have serious differences that have grown over time. My administration is now committed to diplomacy that addresses the full range of issues before us, and to pursuing constructive ties among the United States, Iran and the international community."
"This process will not be advanced by threats," Obama continues. "We seek instead engagement that is honest and grounded in mutual respect."
"This is huge," said Trita Parsi, president of the National Iranian American Council, a group that supports U.S. engagement with Tehran. "First of all, he is addressing the people and the government, which has not been done before. At one point he talks about the Islamic Republic. He's signaling he's not looking for regime change; he's recognizing Iran's system.
"You always heard Rice and Bush say 'Iranian regime,'" Parsi noted. "It's a big difference." That doesn't mean Obama doesn't support Iranian democratization, Parsi said. "But he recognizes the government that exists in Iran right now."
Parsi also found remarkable Obama's comments that he recognized Iran has a "rightful role among nations."
"When he is saying the U.S. seeks constructive ties between the U.S., Iran, and international community," Parsi added, "that is signaling strategic intent. He is making it clear is that where he wants to end up through diplomacy which he supports is a constructive, positive relationship with Iran, to put aside our enmity. That is huge."
Asked if Obama's message to Iran signals a concerted public diplomacy effort related to the Iran policy review underway, the White House official responded: "He's making clear to the Iranian people and government the future that he sees for the two countries and that we're prepared to engage in direct diplomacy."
Full text below:
Today I want to extend my very best wishes to all who are celebrating Nowruz around the world.
This holiday is both an ancient ritual and a moment of renewal, and I hope that you enjoy this special time of year with friends and family.
In particular, I would like to speak directly to the people and leaders of the Islamic Republic of Iran. Nowruz is just one part of your great and celebrated culture. Over many centuries your art, your music, literature and innovation have made the world a better and more beautiful place.
Here in the United States our own communities have been enhanced by the contributions of Iranian Americans. We know that you are a great civilization, and your accomplishments have earned the respect of the United States and the world.
For nearly three decades relations between our nations have been strained. But at this holiday we are reminded of the common humanity that binds us together. Indeed, you will be celebrating your New Year in much the same way that we Americans mark our holidays — by gathering with friends and family, exchanging gifts and stories, and looking to the future with a renewed sense of hope.
Within these celebrations lies the promise of a new day, the promise of opportunity for our children, security for our families, progress for our communities, and peace between nations. Those are shared hopes, those are common dreams.
So in this season of new beginnings I would like to speak clearly to Iran's leaders. We have serious differences that have grown over time. My administration is now committed to diplomacy that addresses the full range of issues before us, and to pursuing constructive ties among the United States, Iran and the international community. This process will not be advanced by threats. We seek instead engagement that is honest and grounded in mutual respect.
You, too, have a choice. The United States wants the Islamic Republic of Iran to take its rightful place in the community of nations. You have that right — but it comes with real responsibilities, and that place cannot be reached through terror or arms, but rather through peaceful actions that demonstrate the true greatness of the Iranian people and civilization. And the measure of that greatness is not the capacity to destroy, it is your demonstrated ability to build and create.
So on the occasion of your New Year, I want you, the people and leaders of Iran, to understand the future that we seek. It's a future with renewed exchanges among our people, and greater opportunities for partnership and commerce. It's a future where the old divisions are overcome, where you and all of your neighbors and the wider world can live in greater security and greater peace.
I know that this won't be reached easily. There are those who insist that we be defined by our differences. But let us remember the words that were written by the poet Saadi, so many years ago: "The children of Adam are limbs to each other, having been created of one essence."
With the coming of a new season, we're reminded of this precious humanity that we all share. And we can once again call upon this spirit as we seek the promise of a new beginning.
Thank you, and Eid-eh Shoma Mobarak.
UPDATE: More reaction and analysis from University of Hawaii Iran expert Farideh Farhi and the Carnegie Endowment's Karim Sadjadpour: "With Obama having clearly expressed his support for reconciliation with Iran, this becomes an internal Iranian battle, and unfortunately, it won't be resolved anytime soon. But Obama shows in this video that instead of tipping the scales in favor of the radicals, as the Bush administration did, he will pursue diplomacy to undermine their narrative that a hostile U.S. government is bent on oppressing Iran."
Farhi analyzes Khamenei's response: "The bottom line is: 'Our nation dislikes it when you again proclaim 'talks with pressure'; we talk to Iran while we pressure them as well – threat and inducement. You cannot talk to our nation this way.'"
Tags: Iran, Obama Administration


The Timex 1000 is the US equivalent to the ZX81. I was given it when in Canada last week and it looks like it's in pretty good shape actually. I'm going to be very careful about firing it up though as I don't want to get the power supply wrong in any way. When it's all up and running I'll post some stuff about what I'm doing with it.


Published in Chinese, this book offers a perspective on the development of the automotive industry in China and its implications for the global automotive industry of the 21st Century.
Bill Russo (罗威)is one of the principal authors, along with other members of the Booz & Company global automotive practice.
Harvard Business Review Online China site recommendation links.
Zhejiang Geely Group is betting its newly acquired, Sweden-based Volvo Car unit can remain foreign enough to win over well-heeled mainland consumers but become Chinese enough to cultivate government support and be attuned to rapidly shifting trends in the booming mainland car market.
"We are a different company now," Volvo Car China chairman Freeman Shen said. "We are still a premium European car brand, but we want to become a company that knows China very well and to make it our second home market."
Perhaps best known for producing safe and straightforward sedans, Volvo hinted at a racier line-up last week with the debut of Universe concept car at the Shanghai car show.
The Universe is larger and more luxurious than anything in the current line-up.
"There are a lot of new elements to that car," says Shen. "So far, the feedback has been very positive."
Volvo, which the privately held Zhejiang Geely bought from Ford for US$1.5 billion last August, this year unveiled plans to sell 200,000 cars on the mainland annually by 2015, up from about 30,000 cars last year.
The company plans to break ground for its first wholly owned mainland car plant in Chengdu in the third quarter and start production in 2013, Shen said in an interview last week on the sidelines of the Shanghai car show.
"We have a very ambitious plan," Shen said. "We have a strong management team ... and we have a lot of support from the government, we have to admit that. And a lot of Chinese consumers are very supportive because, simply, this is one of the first Chinese-owned premium brands in any industry."
In addition to the planned Chengdu facility, which will have an initial output capacity of 100,000 cars per year, Volvo is also mulling a second mainland plant in the northeastern city of Daqing, best known for its oilfields. The Goteborg, Sweden-based firm also plans a research and development centre in Shanghai's Jiading district, where it recently set up its new mainland headquarters.
State firms owned by the governments of Daqing and Jiading helped bankroll Zhejiang Geely's purchase of Volvo, contributing a combined four billion yuan (HK$4.7 billion) in financing or roughly a third of the purchase price, according to Ford's filings to the US Securities and Exchange Commission.
Shen said that being owned by Zhejiang Geely, parent of Hong Kong-listed Geely Automobile, gives Volvo a leg-up over other foreign car brands in the mainland, which, according to Beijing's policies, must manufacture locally through joint ventures with (mainly state-backed) local firms, where their ownership level is capped at 50 per cent.
"Of course, they always say the joint ventures' interests are the priority, but the foreign and the Chinese partners' interests in most cases are not aligned, and that creates a lot of inefficiencies," Shen said.
Analysts said Volvo had a rare opening to the mainland market.
"Having your parent be a Chinese company but your brand still regarded as European is the magic of this relationship, because all of the foreign carmakers that come to the market have to follow a lot of guidelines and policies and if you are the home team, they are going to cut you a bit more of a break," said Bill Russo, president of Beijing-based consultancy Synergistics and a former top Asia executive at Chrysler.
But Russo said Volvo may have to follow the lead of brands like Audi, which tailored its mainland line-up to offer stretched versions of its cars with more luxurious rear seating for the wealthy customers who tend to be chauffeured.
"Volvo will have to be more Chinese if they are going to be successful in China."
At the Auto Shanghai motor show, local Chinese car makers are taking the opportunity to show off their latest models which are now competing with the western and Japanese auto giants.
However, it is in the niche sector of electric vehicles where Beijing sees its best chance to dominate the future market.
Auto industry watchers have been out in force at this year's Auto Shanghai show eager to catch a glimpse of the latest Chinese-made cars.
And the future of the Chinese car industry could be this exotic concept vehicle from local Chang'an Motors.
Chinese car makers in recent years have launched ambitious plans to mass produce cars while competing internationally with established western and Japanese brands.
As the trend for luxurious and spacious cars, much like Geely's Engrand, still dominates the Chinese market, a shift towards greener engines has been a highlight of the show.
Beijing sees electric vehicles (EVs) as a field where it can take a global lead, helping to transform China into a creator of technology.
On the Chang'an Motors stand EVs take centre stage.
Here sporty concept cars, complete with a demo electric charging station, show the country's ambitions to dominate the electric vehicle sector.
One mid-sized car expected to be released in July is the Clover.
Yu Chenglong, vice director of marketing for Chang'an Motors says: "The car we are looking at now integrates energy conservation, zero carbon, and so is green. It is an electric car, zero emissions. It also has our "in drive" technology with our intelligent drive system."
Electric cars are the latest industry in which Beijing hopes to use China's fast-growing market as leverage to develop its own technology and global brands.
It 2009 China surpassed the US in the number of vehicles sold annually and foreign producers are looking to China to drive sales, putting them under pressure to cooperate.
Yu Chenglong said: "This time we have 15 finished automobiles, two engines, and three transmissions, showing our technical research and development strength, we are trying to develop our range, called "ultimate, future life", for our Chinese consumers."
Electric cars also are a key part of China's efforts to curb its voracious appetite for imported oil and gas, which Chinese leaders see as a strategic weakness.
Beijing is trying to generate demand by promising subsidies of $9,200 per electric vehicle. Cities are being given grants to buy electric buses and taxis.
Bill Russo, a former Chrysler executive and analyst, said: "What China is trying to do is mass-market EVs, that's very tough, when you have a product that is inherently more expensive than the alternative which is a vehicle powered by an internal combustion engine."
However electric cars offer China a fresh start in a field with no entrenched leaders.
The burgeoning Chinese electric brands of today could be the industry giants in the future.


^^Blake sent me these beautiful orchids when I finished my Tufts nutrition science certification (and maybe also because our work-life balance had been a little wacky).
^^speaking of... this is where you'll find us most weekend evenings.
^^Gusington Churchill, making family photos fabulous since 2012.
^^my amazing girlfriends sent this arrangement to my office on my birthday, and Blake sent more of those lovely orchids. it was a good day.
^^my sister and her husband have been making tons of progress on the house they bought last summer.
^^I stayed up late reconnecting with a friend and her baby girl, who is the sweetest, most talkative thing.


Image Title: Oil Rubbed Bronze Cup Pull 64mm 3 Regarding Cabinet Pulls Design 12. Filename: oil-rubbed-bronze-cup-pull-64mm-3-regarding-cabinet-pulls-design-12.gif. Image Dimension: 679 x 1019 pixels. Images Format: jpg/jpeg. Publisher/Author: Garrick Grimes. Uploaded Date: Wednesday - April 25th. 2018 22:46:20 PM. Category: Architecture. Image Source: dornob.com.
Tap The Thumbnail Bellow to See Related Gallery of "Oil Rubbed Bronze Cup Pull 64mm 3 Regarding Cabinet Pulls Design 12"


text:
Lara is finalist at the National Centre for Diversity Arts Competition
Written by D Simpson| December 1, 2016| News
The National Centre for Diversity Arts Competition is a competition which encourages students to create artwork representing themes relating to diversity.
Lara decided to enter a photograph that she took and edited as part of her final GCSE project. Her entry was shortlisted as one of the final fifteen entries within the United Kingdom. Lara was invited to attend the awards ceremony at the MacDonald Burlington Hotel in Birmingham where the artwork would be exhibited and the winner would be announced. She has represented Wallace High School superbly by achieving finalist status in this Art competition.
Lara commented, "The awards ceremony was a really exciting experience. I particularly enjoyed hearing from a range of interesting people speak passionately about equality and diversity in the UK and see the other inspiring artwork that was shortlisted in the competition."
Art and Design end of year gallery 2022
Adventures in Art


text:
Q: bibliography with all authors I wish to make a bibliography where each publication lists all the author names, without the use of "et al.".
I have searched stack exchange and tried many different approaches. Most posts recommend biblatex and setting maxnames and minnames but I have found that this doesn't work. The following code below:
\documentclass[12pt,a4paper,english]{scrartcl}

\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
\usepackage[english]{babel}

\usepackage{geometry}
\geometry{a4paper,tmargin=25mm,bmargin=25mm,lmargin=30mm,rmargin=30mm}

\usepackage{txfonts} %Schriftart Times New Roman

\usepackage[
  bibstyle=authortitle,
  citestyle=authoryear,
  maxnames=1000,
  minnames=100,
  backend=biber
  ]{biblatex}

\addbibresource{refs.bib}

\begin{document}

\nocite{*}

\printbibliography

\end{document}

Gives output that compiles to this:

Banos, Daniel Trejo, Daniel L McCartney, Tom Battram, Gibran Hemani, Rosie M Walker,Stewart W Morris, Qian Zhang, David J Porteous, Allan F McRae, Naomi R Wray, et al. "Bayesian reassessment of the epigenetic architecture of complex traits". In:bioRxiv(2018), p. 450288.

So still has an "et al." I suppose I have to modify a style file somehow but I cannot work this out either and would appreciate a pointer in the right direction. Many thanks in advance.

A: Using bibtex and \bibliographystyle{plain} you can list all the author names in the references. Here is your code which is modified
\documentclass[12pt,a4paper,english]{scrartcl}

\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
\usepackage[english]{babel}

\usepackage{geometry}
\geometry{a4paper,tmargin=25mm,bmargin=25mm,lmargin=30mm,rmargin=30mm}

\usepackage{txfonts} %Schriftart Times New Roman

% \usepackage[
%   bibstyle=authortitle,
%   citestyle=authoryear,
%   maxnames=1000,
%   minnames=100,
%   backend=biber
%   ]{biblatex}

% \addbibresource{sample.bib}

\begin{document}

\nocite{*}

%---------added---------------
\bibliographystyle{plain}
\bibliography{bayesian}

% \printbibliography

\end{document}

Below is the contents of bibliography file bayesian.bib
@article {Banos450288,
    author = {Banos, Daniel Trejo and McCartney, Daniel L. and Battram, Tom and Hemani, Gibran and Walker, Rosie M. and Morris, Stewart W. and Zhang, Qian and Porteous, David J. and McRae, Allan F. and Wray, Naomi R. and Visscher, Peter M. and Haley, Chris S. and Evans, Kathryn L. and Deary, Ian J. and McIntosh, Andrew M. and Marioni, Riccardo E. and Robinson, Matthew R.},
    title = {Bayesian reassessment of the epigenetic architecture of complex traits},
    elocation-id = {450288},
    year = {2018},
    doi = {10.1101/450288},
    publisher = {Cold Spring Harbor Laboratory},
    URL = {https://www.biorxiv.org/content/early/2018/10/22/450288},
    eprint = {https://www.biorxiv.org/content/early/2018/10/22/450288.full.pdf},
    journal = {bioRxiv}
}

Compile the file using LaTeX + BibTex (x2) + LaTeX. Output of the code is shown below

A: (too long for a comment, hence posted as an answer)
I cannot replicate the issue you say you're experiencing if I employ the bib entry provided by the publisher (https://www.biorxiv.org/content/10.1101/450288v1):

The bib entry that may be obtained from the link given above actually isn't quite  right: It uses the entry type @article even though cited piece is more a preprint than a journal article. (It got published in Nature Communications earlier this year.) I therefore changed the entry type from @article to @misc, deleted the journal field, and changed the name of the publisher field to organization.
\documentclass[12pt,a4paper,english]{scrartcl}
\begin{filecontents}[overwrite]{refs.bib}
@misc{Banos450288,
    author = {Banos, Daniel Trejo and McCartney, Daniel L. and Battram, Tom and Hemani, Gibran and Walker, Rosie M. and Morris, Stewart W. and Zhang, Qian and Porteous, David J. and McRae, Allan F. and Wray, Naomi R. and Visscher, Peter M. and Haley, Chris S. and Evans, Kathryn L. and Deary, Ian J. and McIntosh, Andrew M. and Marioni, Riccardo E. and Robinson, Matthew R.},
    title = {Bayesian reassessment of the epigenetic architecture of complex traits},
    elocation-id = {450288},
    year = {2018},
    organization = {Cold Spring Harbor Laboratory},
    URL = {https://www.biorxiv.org/content/early/2018/10/22/450288},
}
\end{filecontents}
\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
\usepackage[english]{babel}
\usepackage{xurl}
\usepackage{geometry}
\geometry{a4paper,vmargin=25mm,hmargin=30mm}

\usepackage{newtxtext,newtxmath} % 'txfonts' is obsolete

\usepackage[
          bibstyle=authortitle,
          citestyle=authoryear,
          maxnames=1000,
          backend=biber
          ]{biblatex}
\addbibresource{refs.bib}

\begin{document}
\noindent
\cite{Banos450288}
\printbibliography
\end{document}