Seismic techniques provide the key monitoring capability for verifying site performance at the wide spatial scales required (tens of square kilometres and upwards) and will form the core of the proposal. Our industrial partners, BP and Statoil, have provided access to monitoring datasets from the three global large-scale CO2 storage operations: Sleipner, In Salah and Snøhvit. These include active (time-lapse 3D, multi-azimuth data) and passive seismics, ground displacements from satellite interferometry and reservoir pressure measurements. Monitoring results from these sites are outlined briefly below.
Sleipner has stored more than 14 million tonnes of CO2 in the Utsira Sand, a very large, shallow, saline aquifer that perhaps typifies the 'perfect' reservoir in terms of storage capacity and monitorability (Arts et al., 2008). The CO2 plume shows striking reflectivity (Figure 1a) and large time shifts. High resolution mapping of individual spreading CO2 layers has been history matched against both numerical (Chadwick and Noy, 2010), and analytical flow models (Bickle et al., 2007). More recently, statistical analysis of very small time shifts has been used to constrain pressure increase in the reservoir (Chadwick et al., 2012).
At In Salah, more than three million tonnes of CO2 have been stored in a complex fractured aquifer. Seismic time shifts are evident, aligned to likely fracturing, but diagnosis of these, in terms of fluid saturation or pressure changes, is difficult using conventional analysis. Passive seismics have shown evidence of induced micro-seismicity and satellite interferometry has revealed striking ground displacements above the injection wells (Figure 1b) that have been related to mechanical inflation and fracturing of the reservoir (e.g. Morris et al., 2011).
Snøhvit has stored 1.2 million tonnes of CO2 in a very deep (approx. 2800 m), faulted aquifer. However, during injection, downhole pressures rose significantly and injection was terminated in the preferred storage reservoir (Gilding et al., 2012). Intriguing time-lapse 3D seismic time shifts and reflectivity changes appear to show both CO2 saturation and pressure signatures in the reservoir (Figure 1c). Discriminating between these effects remains challenging.
Figure 1. (a) View of the Sleipner plume in 2006 showing the brightly reflective CO2 plume beneath the reservoir topseal (coloured surface). (b) Shaded contour map of millimetre-scale surface displacements above the In Salah injection wells. (c) Reflectivity changes at the level of the storage reservoir at Snøhvit. Strong changes (red colours) close to the injection point likely correspond to the CO2 plume; weaker, more spatially extensive changes may indicate pressure increase in the surrounding aquifer [black areas correspond to faults]. N.B. white discs correspond to CO2 injection points/wells and all views and maps show areas several kilometres across.


Pizza crostini appetizers with Parmesan cheese.
Paul Martin's on Twitter: "#HappyHour game plan: Prosciutto & Fig Crostini with herb cream cheese and shaved Parmesan... It's kind of a fig deal.
For all appetizers go HERE and for the recipe index, go HERE.
I couldn't get rid of all dairy. Top the crostini with a thin slice of parmesan and your world will be rocked.
Baked Goat Cheese & Marinara Dip with Crostini - A festive holiday appetizer !
... room with custom made labels that I found on Pinterest, purging my closet of anything I hadn't worn in over a year and losing 50 pounds in two weeks.


Bakit parang mas maganda ang Miss Earth nya?
Presenting the race organizers: no kilometer markers, no energy drinks, few hydration stations, no loot bag, expensive registration. Well done har har!
The advantages of wearing a trisuit are hard to ignore. They can make for a fast transition, the fit makes you aerodynamic, the extra cloth may prevent jelly stings, the suit is a good sponsor's advert, and as a team uniform it's a must have.
1. The look: while trisuits look good even awesome on most triathletes I just don't think that it will translate to my physique 'coz I'm so thin my daughter calls me a stickman when riding my bike.
2. I like to swim without a top. It's just me and the 3 percent who swim with our good old speedo trunks..
3. I am not vying for a podium so transition time is not that important to me.
4. I don't have a club or sponsor. Yes, the banners you see here aren't paying me. I just use them.
5. I haven't been stung by a jellyfish... yet.
My advice: buy a trisuit, it's nice to have, it's just not my thing yet.
For duathlons and short distance triathlons I eat and drink these simply because they taste good for me.
Jelly Belly Sport Beans and Bunete bread inside my bento box.
I've never seen quite like it. Is this really how registration is like nowadays? NatGeo's booth at Greenbelt 3 is what a registration site should be: simple, fast, efficient.
If you are a newbie you're more than allowed to follow in my footsteps.
Be sure to pose for the camera while your wave is being called. - Start from the back and be kicked.
Exit the water 31 minutes later. - Use tightly sealed bottled water to cleanse your feet.
Wear your socks and running shoes. - Wipe your body before wearing muscle shirt.
Wear your cycling shorts if you can fit your shoes through it. - Helmet, shades, and forget your race belt.
My friend Pot invited me on his annual 'penitence ride' a term he coined for his Holy Week long ride. As the title suggested it was supposed to be long and hard just like when a priest ordered you to complete the stations of the cross as penance for your grave sins.


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interview, Luna Blue, New Music, Rock Music
Luna Blue – "Tropical" (new single)
Photo: Brian Dukes
New Single: Tropical
Release Date: 2nd January 2019
Hailing from Brighton, Luna Blue are an indie pop-rock band who bring a breath of fresh air. After releasing their debut EP "Nightjar" in 2017 with two singles which featured on the EP, they are ready to show us what they have been working on since their last release.
The quartet have just released their new single "Tropical". The song has such an appealing funky sound even though it has a slight sentimental feel. They created their new music even more positively whilst sticking to their conventional sound. It is a perfect song for any occasion where you can move your feet.
Last week, we asked the band to talk to us while they were still buzzing right after the BBC Introducing live session. And Ryan the guitarist sat down and answered our questions. Get to know Luna Blue!
Very excited to talk to you today! First of all, could you introduce yourself and the band?
Hey! I'm Ryan and I play guitar in the band. The other members are Tom, vocals and rhythm guitar, Nick the bassist and backing vocals and Seb on drums and backing vocals.
Last time I saw you guys was… hmmm June? Time flies!
Wow, it's been a while!
How have you been since? You seem to have had a busy year with some exciting stuff!
We've been great thanks! Since June, we've covered loads of ground. We have been working really hard at our socials, planning a 2019 tour, written and recorded four new singles! The first of which being Tropical! …and playing live on our local BBC Introducing twice!
Sounds fantastic!
Hopefully we'll see you again at the Tropical Launch gig on 12th January at The Prince Albert in Brighton!
It would be great!
So, you are just about to release new single "Tropical". Well, it will be released by the time this interview is published! Could you describe the song?
Tropical is definitely our most 'commercial' track. We wanted to write something catchy, upbeat and as summery as we possibly could. The perfect setting for this song would be with a Pina Colada on the beach partying for sure, perfect to beat away those post-Christmas blues!
Nice! The song definitely gives a beach holiday feel. Does this single lead to the second EP or an album?
Although we actually have 4 new songs written, we've chosen to release them as individual singles. We worked really hard on these four tracks and we wanted to give each one an equal amount of exposure. So, we are releasing them as four singles. It means that we can really focus on doing something exciting with every release for our fans!
Super! Where can we find the song for streaming or downloading?
The song will be available on all major streaming services; Spotify, Apple music, Amazon Music, Bandcamp etc. We will always release our music on streaming services as we want everyone to be able to enjoy our music. But of course we always appreciate anyone that wants to purchase our music or merchandise!
For sure. Could you tell us how you all met up and became a band?
It all started with Tom actually coming to my dorm in our first year at university to play some music for fun. We did write a couple of tracks together and released them. We both really enjoyed playing together, but felt we needed something more to really explore our writing, which eventually lead to the four piece rock band you see today!
Fantastic! How did you decide on Luna Blue as your band name?
I was in a band at college with our drummer Seb. We were called Luna Blue back then, and we really liked the name. So it stuck! It actually came to our original guitarist in a dream! We did have some horrific names before hand. I think we were originally called Deep Wave, which makes us sound like a corny 70s Prog Rock band!
(laughs)
Haha, mind you, Deep Wave could mean something about surfing?! Who are your influences? Does everyone listen to similar music or musicians?
Luna Blue is a big melting pot of different genres. I was hugely influenced by Red Hot Chilli Peppers, Jimi Hendrix and Foals. Tom by Jeff Buckley and Ben Howard, Nick by Prog Metal bands such as Periphery, Animals as Leaders and Seb by similar bands like Tool and Karnivool. We all seem to find a middle ground with indie and it seems to work, but we all like to try to inject some of our sounds into the final product!
Oh that's quite surprising! Though you can tell from your sound that you are not influenced by just one type of music. How do you normally go about writing your songs?
One of us will have some kind of chord sequence we really like and take it to the band. Recently we have been writing everything on recording software. We've found this to be amazing because we can hear all of the different parts and how they gel together. It will usually take us about 1 month to totally finish a track after rewriting it several times. Sometimes a track can be scrapped after weeks of work, but we have an endless backlog of little riffs, licks and ideas to go back to!
Okay. Do you meet up for a band practice every week like most bands do?
We meet up once a week to focus on social media and marketing the band and once again to rehearse as a band. If we need to meet up more, then we make the time. We've recently been preparing lots for Tropical's release, so have been meeting up almost every night after work for about the last two months!!
Really?! might be better living together!
Will you have a special show for the release? Any other shows already planned?
We are playing at Prince Albert on the 12th of January for Tropical's single launch. I don't want to give too much away, but we have loads of special things in store. I hope you like palm trees and bananas… and musical surprises too! (smiles)
Wow, sounds great to me!
Could you tell gig goers what to expect from your shows?
High energy, dancing, partying, banter and an overall great night! We really like to involve the audience as much as we can and make sure everyone is having a great time at our shows. But we also hope that our music speaks for itself too!
It did for me! Is there anything else you would like to say?
We would like to take the time to say thank you for taking the time to involve us in your blog!
Also, get down to the Prince Albert in Brighton on the 12th of January. First 15 people through the door get a special party bag! Everything in the bag is going to be available at the gig only!
Exciting stuff!
You can purchase tickets through the page on our website: https://www.lunablueofficial.com/events/tropical-single-launch
Good luck with your release and thank you for your time! See you again very soon hopefully!
Teri Morris
* Content photo: Alan High Photography
Luna Blue Official Website
January 2, 2019 January 4, 2019 teriBrighton, Indie, new release, pop rock, single, tropical
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Topeka man who ran away with 14-year-old girl sentenced to prison
Feb 10, 2020 @ 5:30pm
A 48-year-old Topeka man who ran away with a 14-year-old girl who he had acted with in a play was sentenced Monday to nearly 10 years in jail for sexually assaulting her.
Michael Fitzgerald, 48, of Topeka, was sentenced to nine years and 10 months for six felonies arising from the girl's disappearance in January 2019.
Fitzgerald met the girl when she was 11, and they later performed in "Elf: The Musical" in 2018 at the Topeka Civic Theater. She was reported missing on January 22nd, 2019. They were found two days later at a hotel in Cortez, Colorado.
He pleaded guilty on December 6th to electronic solicitation of a child, indecent liberties with a child, indecent solicitation of a child, aggravated interference with parental custody, contributing to a child's misconduct, and aggravated indecent liberties with a child.
Fitzgerald will also have to register as a sex offender.
The girl's private school has expelled her but she told KSNT she hopes to start "a whole new book" in life now that Fitzgerald is behind bars.
Copyright © 2019 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed


We here to offer you a wealth of knowledge regarding all aspects of purchasing or selling a home. Whether it is helping you search for your dream home, discussing new Quincy real estate developments, or assisting with the sale of your property, we would love the opportunity to help. Please feel free to contact us with any questions!
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Canberra, open to use with thoughtshots webpage reader to more money Continues through middle school in fragment Tests in classrooms Above a grade tips Students, second, for writing: sample calendar become proficient how To Write An Argumentative Essay 4th Grade in Toward the new common strategy guide for persuasive others how To Write An Argumentative Essay 4th Grade And is links below are a students Can help your opinion persuasive writing. 4 days ago.
Perhaps the biggest mistake people make in writing an argumentative essay is to substitute their opinions for facts. Remember that each claim you make must be supported by solid evidence if your argument is to hold up to counter claims and objections.A common method for writing an argumentative essay is the five-paragraph approach. This is, however, by no means the only formula for writing such essays. If it sounds straightforward, that is because it is; in fact, the method consists of (a) an introductory paragraph (b) three evidentiary body paragraphs that may include discussion of opposing views and (c) a conclusion.
When preparing to write an argumentative essay, it's important to evaluate various sides of the issue. Research your topic by examining both primary (original documents) and secondary (references information from a primary document) sources, as well as evaluating anecdotal experiences. Once you have collected data that supports multiple perspectives on the issue, you can make an informed decision about which side has the strongest arguments or which side you support.
How to Write an Argumentative Essay by Shmoop ..
Keeping these common problems in mind while writing an argumentative essay will ensure you get the best-finished product possible. The goals of your argumentative essay is change the mind of your reader, or at least convince them enough to give their personal opinions a second thought. With credible sources and a levelheaded tone, you will surely affect your readers.
Before you begin writing an argumentative essay you should research the topic area that you will be discussing, so that you have a clear understanding of the different sides of the argument. Gaining a detailed understanding of your topic will not only help clarify the arguments that you need to make in support of your position, but will also enable you to make strong arguments refuting those of the opposition.
it is also known as theparagraph. When students are writing an argumentative essay, they need to of the opposing argument, otherwise writers sound narrow-minded and thereby less effective. So an effective refutation paragraph or the writer's credibility with his/her audience. Rather than weakening the paper, a good concession paragraph will actually strengthen the essay by showing that the writer has thoughtfully considered both sides of the argument before arriving at the final argumentative position.


Welcome Parents and Families! At San Tan Charter School we are committed to safe student information management. To assist us with this we've chosen Infinite Campus as our Campus Portal.
San Tan Charter School is offering a variety of summer camp options to support continued academic and athletic growth as well as provide summer solutions for our working families. We have 9-weeks of half day and full day camps. Choose the weeks and/or camps you want to join.
Online Registration available for most camps or download and bring forms into the front office.
Visit our Summer Camp page for Complete Details.
Login to your Campus Portal and select "Online Registration" at the bottom of the left menu.
Existing Student Registration Deadline is January 31st at 4:00 PM.
Two forms need to be updated each year, please download, complete, and return to school. Forms can be brought into the office or emailed to enrollment@santancs.com.
San Tan Montessori Private Preschool brings in programs which align with Dr. Maria Montessori's philosophy and vision. The Music Together™ program, Carter's Farm, and our Outdoor Environment experiences provide learning extensions and multi-sensorial experiences inside and outside of the classroom.
San Tan Charter School has a 10-month academic year for all classes. Full Day Kinder Tuition is based on the full year's tuition amount of $3000.00, which has been divided into 10 equal monthly payments of $300.00 for your convenience. Tuition for the first month in the amount of $300 is paid at the time of registration.
All hot lunches come with a meat, vegetarian, or salad option as well as 2% white milk or water at a cost of $3.75 per day.
We are excited to announce that at the Power Campus, we have partnered with My Hot Lunchbox, a new lunch program that you will find easy to use and a much more robust menu choice for our secondary students.
1st time user – Select "Create an Account" to be redirected to the Parent Sign Up page. You will add "San Tan Charter School Power Campus" to the account when adding your student(s). For detailed instructions on setting up your new account please download the set up guide.
A laptop is issued to each student in grades 9-12. It is provided to support the learning objectives of San Tan Charter School and is intended for educational purposes only. The laptop is the property of the San Tan Charter School. It is to be leased to the student at a cost of $250.00 per year paid at the time of registration.
Students are issued their their laptop after completing the leasing payment and signing the technology agreement form.


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Book Cheap Flight Ticket to istanbul Now!
IST Istanbul, 26th Jan 2022
Adventurers, explorers, history buffs, foodies: Istanbul can be your dream destination if you call yourself one of them. This gigantic city lies at the crossroads amid East and West, and the influences of its geographic location can be felt everywhere. From the sublime domes and towers of the Hagia Sophia to the iconic Topkapi Palace of the Ottoman Sultan and the ruins of Roman, Greek, Byzantine and Ottoman sites, see anywhere and you will find nothing but the rich past in Istanbul - it's quite fascinating. Apart from sightseeing, Istanbul proffers much more to adore. From the colour and energy of the Grand Bazaar to the exquisite fabrics at boutiques like Haremlique, Istanbul is a great place to shop.
The Istanbul's climate is generally similar to Marmara region; summer months are warm and humid with small rain sessions, especially amidst July-August, winter months can be wet and cold with some snow but not extreme as some other areas of Turkey. But, the spring and autumn are mild - this would be the best time for visitors to come and explore the city's glory.
Currency: Turkish Lira (TRY)
Local time: GMT +3
Avg. Flight Time: 3h 50m
If you want to avoid the crowds and high temperatures, try to visit outside peak summer months (July and August). Plan your long-awaited tour for April and May or the fall for good weather and get hassle-free access to all the famous and must-see attractions.
Istanbul Attractions and Activities
1. Immerse Yourself in Turkish Culture
Stroll the sights in Turkey's largest city, pamper yourself at a Turkish bath, and haggle for carpets or jewellery at the Grand Bazaar.
2. World-Class Nightlife
Istanbul's nightlife pulsates like no other. Sip cocktails and beers in clubs like Reina or Galata bars Maxigala, or listen and enjoy amazing music performances at legendary spots like Dogstarz in Beyoğlu.
3. Architecture and Art
Sacred sites like the Hagia Sophia and Blue Mosque dot across the city, similarly the Dolmabahçe and the Topkapi which are iconic palaces. The views across the Golden Horn are also breathtaking and never can be forgotten.
4. Explore the City and the Beaches
When visiting and staying in Istanbul, you are never far from the coast. Beaches like Babylon and Burc Beach are reachable by public transportation, allowing you to take a splash or swim and admire the sights on the same day.
5. Dine on Delicious Turkish Food
The aroma of food is irresistible on the streets of Istanbul. Try the most delicious kebabs you've ever tasted from restaurants like Antiochia and Çiya Kebap, simit doughnuts at Galata Simitçisi or gözleme (savoury pancakes) at Feriköy Organik Pazarı.
Airlines Operate Flight to Istanbul
London to Istanbul - 3h 50m
Manchester to Istanbul - 4h 5m
Newcastle to Istanbul - 5h 25m
Birmingham to Istanbul - 4h
Glasgow to Istanbul - 5h 50m
Edinburgh to Istanbul - 4h 15m
Belfast to Istanbul - 6h
Most travellers arrive Istanbul via Atatürk Airport which is nearly 13 miles or 21 km west of the downtown area. The most inexpensive route into town is the bus route 96T (₺5), but the Havatas bus service (₺11) is much faster. Faster still is the Metro, which costs ₺3, but it's a 10-minute walk from the airport to the station. Taxis will cost around ₺60.
Transport from Istanbul
The first thing to do in Istanbul is to purchase an Istanbulkart, which works on metros, buses, and trams. It is known for offering much lower prices on all forms of transport but they may vary depending on the distance travelled. It becomes cheaper when more journeys are taken in a time span of 24 hours. The Metro and buses shut down at night. If you are stuck and need a ride, try the "dolums", a minivan system that runs all night and costs between ₺2-8 per journey.
Visa Requirements for Istanbul
Make sure that your passport is valid for a minimum 90 days longer than the duration of the visa. So, if you will receive a 90-day visa, make sure your passport's validity is at least 180 days.
Tips for your stay in Istanbul
If planning to fly in autumn, spring or over Christmas, make sure you book your accommodation at least 3 months in advance.
For festivals and concerts, try and book the tickets at least 2 months in advance.
Make an estimate how much it would cost for museum entries and then compare the figure to the cost of a Museum Pass İstanbul – you may save money (and time) by purchasing one of these.
Even if you're only here for a few days, it's a good idea to purchase a İstanbulkart to use on public transport.
Most of the museums are closed on Monday so it's better you research on which museums are closed/open on Monday and plan accordingly.


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ARCELORMITTAL INVESTS UAH 320 MLN IN UKRAINE IN 2018-2019 TO RESTORE LOCOMOTIVES
PJSC ArcelorMittal Kryvyi Rih (Dnipropetrovsk region) in 2018-2019 spent about UAH 320 million on the program to restore 27 locomotives.
According to a company press release, domestic and foreign analogues were used instead of Russian components during the overhaul of locomotives, thereby neutralizing Russian sanctions regarding the ban on the supply of spare parts and engines for diesel locomotives to Ukraine.
According to the press service, the plant has one of the largest railway fleets in the metallurgical complex: 172 locomotives (126 for servicing metallurgical production, 46 for mining). A few years ago, the company adopted an import substitution program. One of the main partners was Mykolaiv Diesel Locomotive Repair Plant, which established production cooperation with a number of Ukrainian and foreign manufacturers of various railways equipment.
Thanks to joint developments, Mykolaiv plant started installing diesel engines of well-known world companies, namely U.S.-based Cummins, UK-Belgian ABC Corporation, and others, on locomotives. In addition, the latest Heinzmann engine control systems (Germany), a rotary vane compressor jointly with the Italian company Mattei, a modern traction unit of alternating current (Electrotyazhmash), a microprocessor-based locomotive control system, etc. were installed on the machines.
Thanks to the measures taken, the plant in 2018–2019 got the opportunity to restore 11 diesel locomotives, in particular with the replacement of engines and deep modernization. In addition, 16 more cars were repaired on the basis of its two diesel locomotive repair depots.
ARCELORMITTAL, INVESTS, LOCOMOTIVES
ARCELORMITTAL KRYVYI RIH BUYS FOUR CZECH DIESEL LOCOMOTIVES
The Mining and Metallurgical Combine PJSC ArcelorMittal Kryvyi Rih has signed a contract with OTP Leasing financial support for purchase of four locomotives of CZ Loko based in Czech Republic. According to a press release from ArcelorMittal, the enterprise will receive diesel locomotives of an EffiShunter 1600 worth EUR 9 million in 2020.
OTP Leasing Director Andriy Pavlushyn said that the company had thoroughly prepared the given project with ArcelorMittal team and Czeck colleagues from CZ Loko.
"We are glad that the bargain was successful. For us this is a first step towards this direction: in financing operations with the locomotives, which together with our mobile and farm machineries, trucks and vans will enrich a portfolio of the main products of the company," a press service quotes Pavlushyn as saying.
For his part, ArcelorMittal Transport Department Director Oleksiy Rybalkin said that the combine would be the first enterprise in Ukraine that will use Czech locomotives of the new generation.
Diesel locomotive EffiShunter 1600 is intended for shunting and line service. The locomotive is equipped with alternating/direct current power transmission (AC/DC) from the diesel engine to six powered wheelsets. Parameters of the vehicle are optimized for station shunting and for heavy operation on industrial sidings, e.g. in metallurgical, mining and petrochemical sectors, and for the line service.
CZ Loko is one of the largest Czech manufacturers of diesel-electric locomotives and special railway vehicles.
ARCELORMITTAL, CZECH DIESEL, KRYVYI RIH, LOCOMOTIVES
UKRAINIAN STATE-RUN RAILWAY COMPANY IN TALKS WITH CANADA'S BOMBARDIER ABOUT SUPPLY OF LOCOMOTIVES
Ukrzaliznytsia, in addition to France's Alstom and China's CRRC, is negotiating the supply of electric locomotives with Canada's Bombardier, Anton Sabolevsky, the director for strategic development and investment policy of the company, has said in an interview with the Magistral industry portal. "Now Ukrzaliznytsia is actively negotiating with potential partners. The main contenders are Alstom, CRRC, and Bombardier. The main advantage of these manufacturers is that they have ready-made models of locomotives for the 1,520 mm gauge, the rest require quite a long time for such models to be developed," he said.
According to the expert, ultimately, the main selection criterion will be the total cost of an electric locomotive, taking into account its operation life, which includes the initial price of the locomotive, the cost of its maintenance, and the conditions of financing the project, as well as the volume of production localization in Ukraine.
He also said that Ukrzaliznytsia could purchase shunting locomotives from the Japanese company Toshiba.
BOMBARDIER, CRRC, LOCOMOTIVES, RAILWAY COMPANY
UKRZALIZNYTSIA TO BUY SPARE PARTS FOR GENERAL ELECTRIC LOCOMOTIVES
The regional branch Prydniprovska Railways of JSC Ukrzaliznytsia has selected Transportation Ukraine LLC to procure spare parts to U.S. General Electric locomotives for the total amount of UAH 3.12 million.
According to a report in the ProZorro e-procurement system, the deal was signed using negotiations due to the absence of competition among suppliers.
The subject of the deal is eight types of spare parts to General Electric TE33AS locomotives in the amount of 864 units. The term of the delivery is before December 31, 2019.
Transportation Ukraine LLC with a charter capital of UAH 28.1 million was registered in July 2018 in Kyiv. The founder is Transportation Systems Holdings Inc. (the United States). Gokhan Bayhan, GE Transportation's General Manager for Russia/CIS, Europe, Middle East & North Africa, is the head of the company.
As reported, Ukrzaliznytsia has completed the first stage of the strategic cooperation with General Electric on supplies of locomotives.
GENERAL ELECTRIC, LOCOMOTIVES, SPARE PARTS, UKRZALIZNYTSIA
UKRZALIZNYTSIA RECEIVES 30 LOCOMOTIVES FROM GENERAL ELECTRIC UNDER CONTRACT
JSC Ukrzaliznytsia has received the last five locomotive made by General Electric Transportation (the United States), Ukrzaliznytsia Board Chairman Yevhen Kravtsov has said on its Facebook page.
Ukrzaliznytsia received all 30 contracted locomotives GE. The last five met in Chornomorsk on Friday [February 1]," he said.
The received locomotives will be sent to Kriukov Car Building Works (KCBW, Poltava region) for retrofitting, where 10 more U.S. locomotives are already in work.
According to Kravtsov, GE locomotives show themselves to be extremely effective.
"As an example, we save fuel by 30% in the Zaporizhia-Kamysh-Zoria-Volnovakha section. In addition, the locomotives of the old fleet run an average of 360 km per day, and GE diesel locomotives – 540 km," he said.
According to the head of Ukrzaliznytsia, 15 new locomotives now ensure a quarter of diesel locomotive traction in the three regional branches where they operate: Prydniprovska, Donetsk and Odesa.
CONTRACT, GENERAL ELECTRIC, LOCOMOTIVES, UKRZALIZNYTSIA
UKRAINIAN GRAIN FARMERS CANNOT TIMELY EXECUTE CONTRACTS FOR EXPORTS DUE TO LACK OF UKRZALIZNYTSIA'S LOCOMOTIVES
Ukrainian grain farmers cannot timely execute contracts for exports of products due to a shortage of locomotives at Ukrzaliznytsia, the Ukrainian Agribusiness Club has reported. "The main problem of PJSC Ukrzaliznytsia, which impedes the efficient transportation of grain, is a shortage of locomotives. Due to a lack of traction, wagons stand idle at stations and elevators, while the turnover of cars of Ukrzaliznytsia's Transport Logistics Center has increased from five to 11 days over the last two years, private to 13 days," the report says.
According to the association, delays in the transportation of grain crops lead to a breach of export contracts, while transportation rates are declining, and gross production is rising. According to the union, only 500 out of 2,500 Ukrzaliznytsia locomotives work, while the overhauls of many of them were carried out in the 1990s.
At the same time, the association noted an increase in the number of grain wagons in the country: about 11,500 cars are owned by Ukrzaliznytsia, about 10,000 are private.
According to the Ukrainian Agribusiness Club, it's not worth expecting a speedy improvement in the situation with rail transportation because of a lack of funds at Ukrzaliznytsia for the purchase of locomotives in the near future.
CONTRACTS, EXPORTS, GRAIN FARMERS, LOCOMOTIVES, UKRZALIZNYTSIA


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Border Crossings Are at an All-Time High. The Homeland Security Department Is Prioritizing 'Diversity, Equity, and Inclusion.'
Joseph Simonson November 22, 2021 Leave a Comment on Border Crossings Are at an All-Time High. The Homeland Security Department Is Prioritizing 'Diversity, Equity, and Inclusion.' Posted in Conservative News Daily - Breaking News 0 Likes 219 Views
DHS puts DEI ahead of 'customer experience' and 'cybersecurity'
WASHINGTON, DC – SEPTEMBER 24: U.S. Homeland Security Secretary Alejandro Mayorkas speaks at a press briefing at the White House on September 24, 2021 in Washington, DC. Mayorkas announced that the influx of Haitian immigrants camped under the bridge in Del Rio, Texas had been cleared. (Photo by Anna Moneymaker/Getty Images)
Joseph Simonson • November 22, 2021 5:00 am
As patrol agents are overwhelmed with an all-time high number of crossings at the southern border, the Department of Homeland Security is prioritizing "diversity, equity, and inclusion" (DEI) in the 2022 fiscal year, according to documents reviewed by the Washington Free Beacon.
In a November report that outlined initiatives for agencies such as Customs and Border Protection, DHS listed compliance with federal regulations as first among six "priorities." The second was "diversity, equity, and inclusion"—above "customer experience" and "cybersecurity." The department sent the report to staff members following a town hall-like meeting, during which agency heads emphasized to staff the importance of DEI efforts.
That ranking concerned at least one senior DHS official, who criticized leadership for focusing on left-wing political initiatives while the southern border "remains a shit show."
"DEI is the new buzzword at DHS, and it's a top focus at all component agencies," the official said. "Too many officials are spending resources to impress Biden administration officials and political appointees with new initiatives and programs."
As DHS rolls out these priorities, Border Patrol agents are processing an all-time high number of migrants attempting to enter the country. Fentanyl seizures by immigration authorities have also spiked over the last year, contributing to the more than 100,000 American deaths due to opioid overdoses in the last year. On top of that, DHS is facing a potential staffing crisis amid vaccine mandates for federal employees.
Despite those crises, President Joe Biden has advanced DEI programming. In June, he signed an executive order establishing "a government-wide initiative to advance diversity, equity, inclusion, and accessibility in all parts of the federal workforce" that "expands [DEI] training throughout" the government.
A recording of a private question-and-answer session with DHS leadership this month, which was obtained by the Free Beacon, highlights how DEI initiatives are central to day-to-day work by the agency. When asked by an anonymous staff member about supply chain issues, for example, DHS chief information officer Eric Hysen—who worked as the director of the Justice and Opportunity Initiative at the Chan Zuckerberg Initiative and on the Biden transition team—spoke about his concern for "minority businesses" when working with tech contractors.
"One of the things that has been critical for me and [our chief procurement officer] as we think about these elements," Hysen said, "is that we don't want to impose supply chain requirements that limit our ability to move quickly, to move at the speed of mission, but also that don't impact our ability to access and work with small and minority owned businesses, which are a critical part of our vendor base."
DHS did not respond to a request for comment.
Much of the changing culture at DHS can be traced to an agency report entitled "DHS Inclusive Diversity Strategic Plan for Fiscal Years 2021-2024," which was released on Dec. 31, 2020. According to the document, the initiative seeks to "demonstrate our commitment to inclusive diversity as a top priority."
"In 2020, we find ourselves at the brink of change that is not only expected, but required—of the times we are in, and by the future that we are beholden to," Sharon Wong, DHS executive director of Strategic Recruitment, Diversity, & Inclusion, writes in the report (emphasis in original). "As we prepare to welcome Generation Z into the workforce, we must begin to think of harnessing our mission and values to create a workforce for whom belonging is our priority; so that we may benefit from their talent and tenacity, and be elevated by their high expectations of the American government, and uncompromising standards that will stretch us to the fullest expression of public service."
The report notes that reorienting the agency around DEI initiatives began at the end of the Trump administration. The proliferation of DEI programming has only accelerated since Biden entered office, according to the senior DHS official.
The focus on issues related to diversity, equity, and inclusion, the official said, has demoralized many within the agency. When senior DHS officials held town hall meetings with staff in September, for example, they declined answering questions related to the treatment of Border Patrol agents erroneously accused of "whipping" Haitian migrants.
Biden's vaccine mandate for federal employees, as well as looming budget cuts for border security, has many within DHS and CBP considering retirement or changing jobs altogether. The obsession with DEI, some say, feels like an insult.
"It's like this all over the administration," the senior DHS official said with regards to DEI programming. "Why are they thanking us for our service when they want to give us less money and promote debunked stories about how Border Patrol agents abuse migrants?"
First seen at The Free Beacon, Border Crossings Are at an All-Time High. The Homeland Security Department Is Prioritizing 'Diversity, Equity, and Inclusion.'
Author: Joseph Simonson
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Surprise guilty plea in horrific murder case - InfoNews
for Kelowna and Area
Infotel News Kelowna
Surprise guilty plea in horrific murder case
Marshall Jones
Kelowna Law Courts
(MARSHALL JONES / iNFOnews.ca)
A man once convicted by a jury of the first-degree murder of an 85-year-old woman in Penticton, only to be awarded a new trial, has now pleaded guilty to a lesser charge of second-degree murder.
Corey Wolf Swite, 26, ended his re-trial Monday after almost three months of evidence when B.C. Supreme Court Justice Ian Josephson found him not guilty of first-degree murder and accepted a guilty plea to the lesser charge. The Crown had nearly finished its case and it appeared likely that the first-degree murder charge wouldn't stand, which led to the change in plea. Swite was originally convicted by a jury but won a new trial because of procedural problems in his original trial.
Swite told undercover RCMP investigators and later confirmed that he broke into Olive Hill's Bel-Air apartment late one night in August, 2006 to steal some smokes and booze when he accidentally woke Hill up. He told them he smothered her and killed her. He said while he was rifling through her home, he found a condom which gave him the idea of having sex with the lifeless body. Had he raped her before killing her, it would have been a clear case of first-degree murder.
Both first- and second-degree murder charges have a mandatory minimum sentence of life imprisonment. The difference is parole eligibility. Had Swite been convicted of murder in the first degree, he'd have had no chance of release for 25 years.
Now, under the new indictment, Justice Josephson must decide when he is eligible for parole.
Crown prosecutor Rob Bruneau is arguing for 15 years. Defence counsel Kevin McCullough says 10 years is the appropriate sentence, arguing that the court must also take note of Swite's First Nations status.
The sides will complete their arguments tomorrow with a decision expected at a later date.
mjones@infotelnews.ca
Popular kelowna News


text:
Ёнэяма — японское имя собственное; распространено в виде фамилий.
 Ёнэяма, Ацуси (род. 1976) — японский футболист.
 Ёнэяма, Хироси (1909—1988) — японский пловец, призёр Олимпийских игр.

redpajama_set_name: RedPajamaWikipedia


I started New Horizons over 25 years ago after working in the recruitment industry. I had seen that redundancy or sudden career change could often be traumatic and challenging and realised that there was a big need to provide personal, bespoke support rather than what I saw being offered elsewhere where the focus was more on desks and facilities.
My vision was to offer support that was tailored to recognise each person's individual circumstances, needs and priorities. And this vision is still at the heart of what we do today. We call it our 'New Horizons Experience' and not the 'one-size fits all approach' with standard processes and programmes offered by others.
This is our difference and what makes us believe that New Horizons is the best at what we do. Our team of coaches are passionate about helping people realise their talents. Our ethos and guarantee is that every person's programme will be built around their individual needs.
We take a holistic approach with each client. We look at the whole person – their values, needs, hopes and aspirations – rather than just their current job and skillset. Our mantra is about getting the right job, not just the first one that comes along to create long term fulfilment and of course income.
All of our consultants have personal experience of career transition and change whether through redundancy or choice so that they truly understand the range of feelings – loss, fear, anger, confusion – that people may be experiencing.
When recruiting and selecting our coaching consultants, we look for people who will go the extra mile and show real care for the people they support.
I personally meet or speak to everyone who comes to us for help and spend time matching them with the right coach making sure we get the professional and personal chemistry right. I then remain involved to ensure that they get the best possible experience.
Where ever possible, our focus is ensuring long term happiness and fulfilment rather than just providing an immediate short term solution. No basic quick fixes but real solutions. For people on our executive programmes we will support them until they find their next role.
Our track record means that we can assure each person that they have a very high chance of landing a great next role or making the career transition they really want.
We also offer specialist coaching support. Our team can work with you and your people on leadership development and career progression through to building high performing individuals and teams.
Our prices are clear and simple with no hidden extras – I'm very happy to have an initial discussion at any time so please do get in touch on 0044 (0)207 831 9843 or send us a message now.
Isobel Bruce and her team at New Horizons are always calm and efficient, never hurried, always patient and in control. They instilled confidence even in our darkest moments. It feels like they really care about you – and your future. Isobel believed the best and encouraged us to dream while keeping two feet firmly on the ground.


Today I'm going to show you how you can run a DNX application in a Windows service because we recently needed to do this, and while there are many posts out there asking how to do it, the answers would lead you to believe it's impossible. For this example we're going to be using the beta6 version of ASP.NET 5. If you don't yet have DNX, you should go here to get started.
First, remove the DNX Core reference, this is a windows service after all, so no point in trying to be cross platform today.
Under frameworks:dnx451, add a frameworkAssemblies reference to "System.ServiceProcess": "4.0.0.0"
Change your command key to something simple like "run" or "runservice". You don't have to do this, but it makes it more clear later what we're doing.
sc.exe create <service-name> binPath= "\"<dnx-exe-path>\" \"<project-path>\" run"
sc.exe create <service-name> binPath= "\"<dnx-exe-path>\" -p \"<project-path>\" run"
sc.exe is a built-in tool that lets us perform a number of operations on a Windows service. Here we're using it to create a new service. The very first argument that the create operation needs is the service name. This is the name that will show up in the services snap in. You can set this to any value, but since our example application is called MyDnxService we put our adventurous nature aside and simply used that.
Since dnx.exe is the application that runs a DNX application, we're going to need to point to it via its full path. If you install DNX via DNVM the default install directory (at least on our machines) is c:\users\\.dnx\runtimes\\bin\dnx.exe but if you aren't sure where on your machine it is just open a command prompt and run where.exe dnx.exe and it should tell you where to find it. Since the path to DNX could have spaces, we're wrapping that parameter in quotes too, but since these quotes are inside the quotes we specified for the binPath= parameter to sc.exe, we need to escape them.
Next we need to tell DNX where to find our application. If you use dnu publish to publish your application it will generate a .cmd file for you that you normally would use to launch your application. You cannot use that .cmd file when running your application in a Windows service but if you open that .cmd file you'll see a path for --appbase and that's the one we want. Again, escape the quotes around this path for safety.
Finally we tell DNX what command within our application to run. Remember above in the project.json file we named our command key "run"? that's what this value specifies. So if you named your command key something else, just replace the "run" parameter to DNX with whatever command key name you chose in your project.json.
sc.exe create MyDnxService binpath= "\"C:\Users\dave\.dnx\runtimes\dnx-clr-win-x86.1.0.0-beta6\bin\dnx.exe\" \"C:\Users\dave\Desktop\DnxWindowsService\src\MyDnxService\" run"
sc.exe create MyDnxService binpath= "\"C:\Users\dave\.dnx\runtimes\dnx-clr-win-x86.1.0.0-beta8\bin\dnx.exe\" -p \"C:\Users\dave\Desktop\DnxWindowsService\src\MyDnxService\" run"
Now that our application has been installed as a service, it's time to revel in the fruits of our labor. To run the service, open the Services MMC Snap-in, find the service we installed by its name and start it. Open Event Viewer, go to the Application log and you should see the text that we output from our OnStart() override in our application. Stopping the service and refreshing the event log will show the stop message. As I said earlier, this is a super basic demonstration of functionality, but it's the basis for running any DNX application in the context of a Windows service.
Taskmatics Scheduler currently hosts the administration website from inside one of the Windows services that are installed. In its current implementation we couldn't support ASP.NET applications because only IIS would provide the environment necessary to properly run each request through the pipeline. With ASP.NET 5, the game changes, and you can host ASP.NET applications from a console application without being dependent on IIS. After some headbanging we are successfully running our MVC 6 web application inside of a Windows service, which you can now read about here.
Check out Erez's follow up post showing you how to host a fully functional ASP.NET site from a Windows service, which has just been posted!
Hi Dave, thanks for the article…very helpful. An issue I ran into was that after deploying I'm having a hard time accessing configuration values from my Config.json. While in Dev, I can access them easily using Environment.CurrentDirectory. But after installing as a service, Environment.CurrentDirectory resolves to C:\Windows\System32…trying to get the appdomain base directory goes to location of the dnx.exe. Is there an easy way you discovered to determine/access the appbase from code?
Thanks Dave, for some reason I thought that was only applicable to web projects…worked like a charm.
the DNX path is correct (available from a command window), I am pointing to the folder inside the SRC folder (when publishing the windows service) and the name of the command is correct…Any ideas of what may be going on?
sc.exe create binPath= "\"<dnx-exe-path>\" -p \"<project-path>\" run"
Thank you so much!! All sorted now. Now I just have to code the current service I need!
Is it possible to publish the service as a standalone application/executable which is then registered by sc.exe? or does it always have to be run via dnx? This means I need to have DNX installed on the target machine.
The hosting model is in the process of being changed. DNX is actually going away. Applications will compiled using a new CLI called 'dotnet'. Parts of DNX will be embedded in an application's compile output. You will be able to launch your app directly using this new approach. With that, you can have SC point directly to that.
I will be posting a follow up to this article on how to do this when the RC2 bits are released in late February 2016.


text:
Q: Naming batch file Gradle's application plugin I would like to give a custom file name to my batch file inside the archive/distribution when using Gradle's application plugin.
Following is the build.gradle file.
apply plugin: 'application'
mainClassName = 'com.org.test.TestMain';

dependencies {
 compile group: 'com.oracle', name: 'ojdbc7', version: '+'
}

I would like to rename test.bat to abc_xyz.bat. in the distribution.
Can anyone suggest how this can be possible?
Thank you.

A: Try:
createStartScripts {
    applicationName = 'abc_xyz'
}

Not tested it though...

A: If you're using the Kotlin DSL
tasks.withType<CreateStartScripts> {
    applicationName = "blah"
}

would create blah and blah.bat. Verified with Gradle 6.6.1.

redpajama_set_name: RedPajamaStackExchange


text:
Tyson's 3 lifts No. 19 Clemson to 51-50 victory over Hokies
by: By PETE IACOBELLI
CLEMSON, S.C. (AP)Hunter Tyson had the option to pass, drive or shoot on Clemson's final play. Tyson chose to follow coach Brad Brownell's main instruction in the time out with the Tigers down by two: "If you're open, shoot it."
Tyson did, making a 3-pointer with 12 seconds to go to lift the 19th-ranked Tigers to a dramatic, 51-50 victory over Virginia Tech on Saturday.
Tyson had missed five of his previous six from behind the arc. Yet, Brownell called his number.
"They stayed confident, drew up a play for me and I shot it pretty well," Tyson said.
Did you have any doubts it wouldn't go in?
"No," Tyson said with a smile.
PJ Hall had 20 points and eight rebounds while Tyson finished with 12 points and nine boards as Clemson (16-4, 8-1 ACC) continued its surprise run atop the Atlantic Coast Conference.
"I just felt like he was going to make a play today," Brownell said of Tyson, who had five straight double-doubles in ACC play earlier this season.
Tyson's play helped the Tigers bounce back from their first league loss after returning to the Top 25, at Wake Forest 87-77, on Tuesday.
Brownell acknowledged it was not an "aesthetically pleasing" game – both teams shot under 39% and combined to go 9 of 40 on 3s – but his players kept up their rugged defense to keep within reach after the Hokies rallied from five down to lead in the final three minutes.
Virginia Tech was still up 50-48 on Grant Basile's foul shot before Tyson's big moment.
The Hokies had a final chance, but Hunter Cattoor's 3 was off the mark and Tyson came up with the ball, holding it high as time ran out.
The sold-out crowd erupted as it had moments before as Tyson's shot went through.
Brownell said the game was important to show Clemson, which came in averaging nearly 76 points a game, can win in different styles. "This is when you have a good team," he said.
Clemson, which trailed 33-26 early in the second half, had regained momentum after Hall's three-point play built a 44-39 lead with less than eight minutes left over the cold-shooting Hokies, who were in the midst of a 1-for-16 run from the field. But Michael Collins Jr.'s 3 and Basile's inside shot tied things at 44 to set up the final stretch.
Basile, who led the Hokies with 13 points, missed the second of two foul shots with 21.5 seconds to hold a 50-48 edge.
For Virginia Tech, coach Mike Young said there's plenty of time to regain its footing.
"You turn the page and move on with the hand we've been dealt," he said.
Virginia Tech: The Hokies were way off target throughout the second half, finishing the period with only six field goals on 25% shooting. From long range, they were worse as they went just 2 of 11 behind the arc.
Clemson: The Tigers need injured junior point guard Chase Hunter back in a hurry. Without him there this week, Clemson fell at Wake Forest and was in a tight one throughout with the Hokies.
CLEMSON INJURIES
Brownell was unsure when his two injured players, Alex Hemenway and Hunter, might return. Hemenway, a senior who's perhaps the team's most reliable 3-point shooter, has missed the past eight game. Hunter has missed the last two. Brownell said both are expected back at some point this season, although he couldn't pinpoint when.
Virginia Tech returns home to play Duke on Monday night.
Clemson hosts Georgia Tech on Tuesday night.
Two SFA student athletes dead after Corrigan crash


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text:
Pharma Strategy Blog
Commentary on Pharma & Biotech Oncology / Hematology New Product Development
KOL Interviews
Science Fridays
Biotech Strategy Blog
Novel Targets
Sometimes in cancer research there really is hope
By MaverickNY on November 16, 2010
It's easy to forget that oncologists (whether medical, radiation or surgical) and hematologists deal with death and dying every single day, it's sadly an integral part of the daily job. Sometimes though, something comes along that offers hope or perhaps a glimmer of possibilities that life might be significantly extended beyond what is considered usual.
As a marketeer, I was also lucky enough to be a small part of one of those moments in the brief history of time.
Much of the data we see in oncology is about small incremental improvements – a few weeks here, a few months there. We rarely hear about the stunning improvements of a several years though, because they mostly belong to rarer diseases, but occasionally something bigger than the sum of the parts comes along.
Way back in 1999 when I arrived in the US, I found myself in an empty office with a huge book (De Vita's Principles and Practice of Oncology) on the desk and a list of about a dozen compounds and people associated with each project team. One of those was an early phase I compound called STI571, which later became known as imatinib (Gleevec), a breakthrough treatment for chronic myeloid leukemia (CML).
People often ask what it's like to be involved with new product development. The short answer is it's a bit like a roller coaster – you have to learn to terminate the also-rans early and reinvest resources in more promising projects and of course, picking the winners from the losers is never as easy as it looks, as well as drive and motivate a diverse bunch of people so that great teams are formed. It's about quiet leadership, inspiring others to go above and beyond rather than rah rah management, which tends to be more about politics and self interest than anything else. Basically, it means getting everyone on board, move the project forward expeditiously and navigate the challenges along the way and have some fun together as well, because:
you spend 12 hours a day in their company
you really want this to end well for patients
be a meaningful experience for all involved.
On bad days, fire drills for someone else's urgent licensing project/evaluation may well derail you from your focused efforts.
On good days, you get to meet the physicians involved in the clinical trials, hear their stories, you meet real patients in the clinics and hear their stories too… about hope, endurance, fear, the funerals they planned and the genuine wide eyed wonder of various test results that show the drug is working and they're actually on the long road to recovery and getting their life back. At that point, everyone cries, even the cynical curmudgeonly ones.
This is ultimately what many of us really live for in the Pharma industry – an opportunity to make a real difference to people's lives and help them beat the odds.
With that background, you may all be wondering where I'm going with this post. The answer is simple. Last night I was checking out the latest Blood Journal online and spotted a paper from Tim Hughes and the International Randomized Study of Interferon and STI571 (IRIS) investigators. It describes the latest update from the trial, which opened to accrual in early 2000, ten years ago. I had goosebumps waiting for the article (see reference below) to load – an update a decade on from initiation of a cancer trial? How many times do you hear about that in the news? You don't, typically.
What was the article about?
"This study examines the prognostic significance of early molecular response using an expanded dataset in chronic myeloid leukemia patients"
One of the most important measurements in CML is Major Molecular Response or MMR, which refers to the level of transcripts in the blood ie BCR-ABL is less than 0.1%. The lower the levels the better, due to a lowered leukemic burden and risk of relapse.
What does the data now tell us?
"Serial molecular studies demonstrate decreases in BCR-ABL transcripts over time."
"Patients with BCR-ABL transcripts >10% at 6 months and >1% at 12 months had inferior EFS and higher rate of progression to AP/BC compared with all other molecular response groups. Conversely, patients who achieved major molecular response by 18 months enjoyed remarkably durable responses, with no progression to AP/BC and 95% EFS at 7 years."
Broader impact of this data:
Prior to the approval of Gleevec, people newly diagnosed with CML had maybe a typical lifespan of 3-4 years with interferon, longer with stem cell transplants, but with a high cost in terms of long term side effect management and maybe a year or less if unfortunately diagnosed with accelerated or blast crisis CML. These days, the outlook is much better. According to some of the investigators I've spoken to recently, a few of the original patients who entered the accelerated phase trials in 1998/1999 are still alive, which is amazing when you consider it's over 10 years on. They've not only beaten the odds but for many, they were able to live a fairly normal life, something none of us imagined in those days. For newly diagnosed patients, the TKIs now means that 10 years (not weeks or months) extra life is a reasonable and realistic goal to aspire to. For most people, there are also 3 excellent choices whereas before the choice of interferon or stem cell transplant was much starker.
This is the first time I've really been convinced by the data that there is compelling evidence for a strong association between the degree to which BCR-ABL transcript numbers are reduced by kinase therapy and long-term clinical outcome. This is something Tim Hughes has been raising for several years, with the idea that people who achieve a deep molecular response are more likely to sustain better long term outcomes. Before, it very much a theory or even a hope, now it's reality.
This data also has a major impact on the second generation TKI's, because both nilotinib (Tasigna) and dasatinib (Sprycel) have both been shown to be superior to imatinib in frontline (newly diagnosed) CML in terms of earlier and deeper responses. Now, we don't have any long term survival data beyond 18 months to two years for either of the 2nd generation TKIs compared to 7 or 8 years survival data for Gleevec, but this new evidence suggests that attaining a sustained MMR is ultimately best for the long term health of people with CML.
In general efficacy terms, it's like going from a drug that offers 90% response rates to ones that incrementally improve it to say, 93 or 94%, but the real impact is at the molecular level because if you can achieve an MMR, ie reach what Tim Hughes called the 'safe haven' at ASCO, you are less likely to relapse. For the first time I can see that being a real advantage for the 2nd generation TKI's over Gleevec, since the MMR data with the second generation TKI's is superior to Gleevec. That said, for people who are doing well on Gleevec and have attained a good molecular response, there is no reason to change.
There are also several other TKIs in development, including bosutinib (Pfizer) and ponatinib (Ariad). Ponatinib is particularly exciting because it inhibits the rare T315I mutation, which none of the others do and is currently in phase II clinical trials. This is one to watch out for in the future.
Either way, they're all good drugs and I'm personally delighted to have been a smart part in the early development of one of them; it's a privilege to have worked with some great investigators and as well as learning from many wonderful people dealing with cancer.
With this new data and scientific evidence, I can see the mantle is finally passing on to a new generation of therapies. To have one great drug approved for CML that made a genuine difference is truly amazing, to have 3 approved is incredible and there a few more still in development. For people living with CML, there is indeed Hope.
Hughes, T., Hochhaus, A., Branford, S., Muller, M., Kaeda, J., Foroni, L., Druker, B., Guilhot, F., Larson, R., O'Brien, S., Rudoltz, M., Mone, M., Wehrle, E., Modur, V., Goldman, J., Radich, J., & , . (2010). Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS) Blood, 116 (19), 3758-3765 DOI: 10.1182/blood-2010-03-273979
I'm a former employee of Novartis and worked on the early development and original launch of Gleevec in CML and GIST. My opinions are my own, but I'm clearly biased by the incredible experience 🙂 Novartis has also been a client, but was not involved in any way with this post.
Author owns no shares in any of the companies mentioned.
2 Responses to "Sometimes in cancer research there really is hope"
Mark Fortner November 16, 2010
My cousin Leigh has CML and I can tell you that the work that you and others did at Novartis has made all the difference in her life. CML has gone from being a death sentence for her, to a chronic condition that she can cope with.
Thank you for all the work that you and your colleagues have done.
maverickny November 16, 2010
Sorry to hear that your cousin has CML, Mark, but I'm really pleased to hear that she's doing well. The personal stories I heard from people were truly amazing. The patients are the real stars of the show.
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text:
Q: 500 errors when trying to refresh Spotify token C# I keep getting 500 errors when trying to refresh my Spotify token.
error: {"error":"server_error"}
request:
POST https://accounts.spotify.com/api/token HTTP/1.1
Authorization: Basic ZWM.....WI=
Host: accounts.spotify.com
Content-Length: 170
Expect: 100-continue
Connection: Keep-Alive
grant_type=refresh_token&refresh_token=AQA9.....p5qc
code:
string request = "https://accounts.spotify.com/api/token";
        StringBuilder sbOutput = new StringBuilder();
        StringBuilder sbBody = new StringBuilder();
        sbBody.Append("grant_type=refresh_token");
        sbBody.Append("&refresh_token=" + spotifyToken.RefreshToken);
        //sbBody.Append("&client_id=" + "ec41.....19");
        //sbBody.Append("&client_secret=" + "9b...5b");

        string clientIdAndSecret = "ec....19:9ba.....e5b";

        var plainTextBytes = System.Text.Encoding.UTF8.GetBytes(clientIdAndSecret);
        string clientIdAndSecretBase64 = System.Convert.ToBase64String(plainTextBytes);

        Dictionary<string, string> headers = new Dictionary<string, string>();
        headers["Authorization"] = "Basic " + clientIdAndSecretBase64;

        response = SendRequest("POST", request, sbBody.ToString(), headers, ref sbOutput);

SendRequest method:
if (!string.IsNullOrEmpty(url))
        {
            using (var client = new HttpClient())
            {
                //Create request URI
                Uri requestURI = new Uri(url);

                //Create Stream from the content
                Stream bodyStream = new MemoryStream(Encoding.UTF8.GetBytes(body ?? ""));
                HttpContent requestContent = new StreamContent(bodyStream);

                //Headers
                foreach (KeyValuePair<string, string> pair in headers)
                {
                    client.DefaultRequestHeaders.Add(pair.Key, pair.Value);
                }

                Task<HttpResponseMessage> responseTask;

                switch (httpWebRequestMethod.ToUpper())
                {
                    case "POST":
                        responseTask = client.PostAsync(requestURI, requestContent);
                        break;
                    case "GET":
                        responseTask = client.GetAsync(requestURI);
                        break;
                    case "DELETE":
                        responseTask = client.DeleteAsync(requestURI);
                        break;
                    case "PUT":
                        responseTask = client.PutAsync(requestURI, requestContent);
                        break;
                    default:
                        return HttpStatusCode.Unused;
                }

                //Lets wait
                responseTask.Wait();

                if (responseTask.IsCompleted)
                {
                    HttpResponseMessage response = responseTask.Result;

                    string resultBody = response.Content.ReadAsStringAsync().Result;

                    sbOutput.Append(resultBody);

                    return response.StatusCode;
                }
            }
        }

        return HttpStatusCode.Unused;
    }

any help would be much appreciated as I am ready to bash my head into a wall!
Thanks :)


A current study by a major New York-based on the web evaluation organization on house safety, sought to seek out the part and location of monitored alarm technique in contemporary home safety. And, in that regard, taking into consideration the very Leading PRIORITY that Americans spot in dwelling safety plus the safety of their properties, a lot more specifically in today's desperate economy, the pretty Key question that the reviewers 1st sought to find out, was basically this: is really a good and reliable burglary alarm technique (just assuming a customer can locate one particular) an effective tool that could deter and stop house break-ins or burglaries?
Feeling protected inside your property is amongst the most significant points for any residence owner. Using a Monitronics Alarm Method you may rest assured that the fire and police departments or an ambulance is obtainable to you after you need it. Mastering your Monitronics alarm method by following these couple of and very simple measures. Before you realize it, you will be 1 step closer to getting the safest atmosphere possible.
Due to it really is tremendous deterrent effect power or factor. Says Chris E. McGoey, an internationally acclaimed expert and in all probability on the list of foremost authorities on property safety management in America who generally operates with the media on residence violence, crime and burglary prevention and is a frequent specialist witness in court situations on such matters all through America, who was consulted by study's reviewers, among other sources, alarm systems deter burglaries simply because they increase the possible and [provoke inside the possible burglar the] fear of becoming caught and arrested by the police. The deterrent worth comes from the alarm enterprise lawn signs which might be placed in the protected premises, and in the alarm decals around the windows. House and apartment burglars will usually bypass a home with visible alarm indicators and can visit yet another house that doesn't have such a sign.
Alarm systems can be an awesome addition to any property or company, and bring peace of mind to individuals who reside, function, and own the building. Being aware of your alarm program will make it that a lot extra productive of a deterrent to burglary, nevertheless, when the burglar knows far more about your system than you do, they could take advantage of little flaws that could finish up costing a huge number of dollars of damage and theft, or worse. It turned out, nonetheless, in the researchers' findings, that the answer to that critical question is YES, it is, and within a Massive Way... BOTTOM LINE:Overwhelmingly, by the overwhelming volume of information accumulated by the specialist researchers of this New York investigative workplace, the almost conclusive obtaining in the researchers is the fact that the mere reality of just possessing a superb, professionally installed and monitored ELECTRONIC Household Security Method ALONE, DRASTICALLY REDUCES the possibility of having a BURGLARY within a dwelling, and hugely DETERS BURGLARS from hitting a home. (Just because it does, at the same time, in respect to other significant danger and emergency conditions).
Get your alarm program. You'll wish to initially get a Monitronics alarm system, which might be completed by going to their internet site and filling out a kind or calling to have a representative come out and demonstrate their program. Following functioning at the biggest alarm corporation in the nation, I saw that people who ended up unsatisfied with their protection, or ended up getting to recover from a significant loss as a consequence of break in, produced a few of these very easy, easy to miss blunders.
- A current 2009 Rutgers University study by its School of Criminal Justice, working with 5 years of data, essentially the most comprehensive of its kind ever carried out, scientifically proved that burglars, by a margin of as considerably as 30 to 40 percent, usually keep away from houses with burglar alarm systems, because the study further identified that an installed burglar alarm makes a dwelling much less attractive towards the would-be and active intruders and protects the residence without having displacing burglars to nearby houses. Activate your method. After you have an Monitronics alarm system, you'll have to activate it. You could do in two ways. Initial, in case you had an installer set up the technique for you, he will activate your method at that time.
- That, in deed, in an earlier study in 1994 that was primarily based on interviews with burglars, Burglars on the Job, which had been published by Northeastern University Press, researchers had made a equivalent locating, and had concluded that, Most offenders, although, wanted to prevent alarms altogether and, upon encountering such devices abandoned all thought of attacking the dwelling. Virtually each alarm technique owner is aware that their technique runs off with the electricity on the property, it truly is either plugged into a wall or it can be hard-wired in to the developing. There is certainly a problem with that having said that: If the electricity goes out, a breaker flips, or the plug comes loose, the alarm method loses its primary supply of power!
- That, in line with a Temple University study headed by Professor Simon Hakim, Director with the university's Center for Competitive Government, a monitored alarm system makes a property 3 occasions significantly less most likely to be burglarized versus a household with out an alarm. Businesses with no alarm systems are 4.five times far more most likely to become burglarized than the ones with electronic security system. And, lastly, losses resulting from burglary average 400 significantly less in residences with no alarm security systems. Arm your method, be certain all doors and windows are closed. Press the Doors and Windows button. When arming the technique at night, press the button twice. A remote control may be utilised to arm and disarm your Monitronics alarm as well. The controller is accessible in the time of purchase.
- That, as outlined by confession made by the burglars, 9 out of 10 convicted burglars admitted that they would stay clear of generating a burglary try altogether on a residence that is protected by an alarm program. (U.S. Division of Justice study, 1999). One OTHER Essential Getting Of these RESEARCHERS, Though IS THIS: That, what's possibly of the most essential significance of all, on the other hand, is the fact that you decide on an electronic technique that is of your Suitable brand from a excellent business. Like any other market, you will find good brands and firms, and you can find undesirable brands and companies. Backup batteries are what your alarm technique definitely will depend on throughout a energy outage. These are ordinarily located within the panel or, in the case of enclosed systems, in the keypad itself. What most owners are certainly not conscious of, is that these batteries do not have a extremely extended life, and they must be maintained periodically to work at all. An old, worn out battery, or one that just will not be hooked up ideal, will not power the program.
In deed, in accordance with this discovering, as a homeowner or consumer when you select the improper or incorrect property security method, or, even worse than that, the wrong or unreliable company which provides or installs the system for you, you stand a significant opportunity of sustaining serious break ins, and even danger to life, that is just primarily attributable to that certain element alone! And, additional a lot more, that you may well, in stead, possibly uncover your self in even worse shape than you have been ahead of you initially went for the house safety system.
- That, an efficient residence safety system (but 1 from a trustworthy residence safety organization) tends to make a residence three times Significantly less Likely to become burglarized, in accordance with a National Burglar and Fire Association study (2004). In addition, having said that, the 2009 study by Rutgers University, initially cited above, identified that although possessing a residential burglary alarm method within a house does, in deed, decrease crime by as a great deal as 30-40 percent, it does so, although, not just around the property only which has the alarm system, but in the Complete surrounding region. Select and use a pin number. To disarm your method, enter the four-digit PIN quantity that you simply chose at the time of activation. Press gradually and firmly to be confident the number is entered properly.
Activate the emergency buttons on your Monitronics alarm by pressing the suitable button twice. This measure is put in place to ensure you might be genuinely in an emergency circumstance. Monitronics also includes a silent alarm function in case of residence invasion. For safety motives, you may make contact with the firm to discover extra regarding the function. After your alarm goes off, Monitronics will speak to you by means of the method to ensure that every little thing is okay.
- That installation of electronic safety solutions by Americans, and use of expert services (and also the spending) on them, has been expanding at an estimated four.three percent per year (STAT Sources, Inc., a Newton, Mass, complete service market place study organization specialized in such matters).
Years ago, bells have been used in shops and also other public places. This was to announce a client or other particular person coming in if the shopkeeper was in the back of the retailer. They are nonetheless applied for small retailers and in some people's residences. These could be holiday bells as element of a decoration, a single cow bell, or any quantity of other types. These bells come in all number of sounds and appearance. Most of them are very sensitive to motion. They may notify you in the event the front door, or any door is opened as they sound at the slightest movement if hung appropriately.
- That 94 percent of property alarm owners are happy with their alarm systems (Prof. Simon Hakim's study of Temple University). That 90 % of the Police think that alarms deter burglary attempts. (STAT Resources study). That is one particular practically absolutely everyone knows about, irrespective of whether they've an alarm system or not. We've got all observed the movies where the burglar sneaks around outside the home till he comes across the phone line entering the property. He pulls out his snippers, and cuts the line. Then, when he busts open the window or front door, the alarm goes off, but no one can get the signal.
- In line with a Board Resolution passed by the International Association of Chiefs of Police in 1994, alarm systems, providing, even though, they're professionally installed and monitored, are valuable instruments to deter crime and offer reassurance for both residential customers and business enterprise owners.
In point of reality, having a fantastic monitored burglary alarm method isn't only crucial and successful as a burglary deterring tool. But, according to safety specialists, pound-for-pound, having a monitored residence alarm security method, which they strongly emphasize Has to be a fantastic and trustworthy brand, is maybe the top and SINGLE MOST Successful Resolution that 1 could institute in obtaining a home that scares away possible burglars and keeps them away from your household, and your family members security. As opposed to most items inside the motion pictures, that is one that Hollywood got appropriate. Standard alarm systems make use of the phone line to send out any signals at all, such as fire, burglary, and carbon monoxide signals. With no the telephone line, nothing at all is received by the alarm corporation, and no call goes out to the authorities. Even several phone line systems are pretty effortless to disable from the outside of your constructing.


Created in about two months, the Portal Gun is a copy of the main implement used in VALVe Studio's 2007 release, Portal. As one of my first major projects, it helped spark my appreciation for props and replica design.
This project was revisited twice more before the final version was completed in April of 2011. The first remake, V2, was auctioned at the Child's Play Charity dinner in 2010 as a featured item and the finale of the show. Its sister gun currently resides in VALVe's Seattle offices.
Click here for the Portal Gun V1 design and build log.


Why Convert A Gas Car To Electric ?
The first thing I had to decide was whether my miles driven was with-in the current technology limits of the electric vehicle. Would I have problems on a regular basis with a limit of 50-75 miles? The answer was NO.
My drive to work was 7 miles one way, my friends all live with-in 30 miles of my home, and my long trips were limited to 3-4 times per year. These long trips could easily be covered by a rental car and save me money in extra insurance costs and payments on a second car.
The second thing I had to consider was what kind of car to convert. Did I need a practical vehicle like a four door Rabbit that could haul people and groceries with equal ease, a pick-up truck, or something fun that I would enjoy driving for a long time.
I opted for something fun to drive and decided on the Porsche 914. The Porsche 914 has been successfully converted by a few other people and I liked the looks of it. It is also a car that there are quite a few of, so finding upgrade parts for the car itself should not be a problem. The car I bought had a blown engine, so I got it for a reasonable price and the body was in very good shape with no dents or rust problems that could cause structural integrity concerns. This is an issue that is very important due to the added weight of the batteries.
In a related direction came an important decision on how I wanted to use the car. Was I more concerned with speed or distance driving? This is important because it would determine how I would configure the vehicle and what kind of components and batteries I would use.
Speed won. After all the 914 is a sports car and I wanted to be able to show off what an EV can do and prove that they are NOT golf carts. I wanted to have no trouble with keeping up with traffic on the freeway and the distances I travel around town would not be affected as 90% of my driving is less than 35 miles a day. I also wanted to use readily available, off-the-shelf components and batteries to show the public that EVs are here now and that THEY can own one.
What did this mean? It meant that I would want to use 120volts or more for speed (I decided on 144volts) and that I would have to use something other than 6 volt batteries due to weight concerns. I could squeak by with 120volts and 6volt batteries, but the car would be at or over the designed gross vehicle weight, but at 144volts I could not do this. There is also a space constraint on where you can mount alot of batteries.
After alot of consideration I decided to use a new 8 volt battery that Trojan had just come out with. This battery is a comprimise between the 6 volt and 12 volt batteries. I'm hoping it works for my purposes. The weight will be a little more than using 12 volt batteries and the range would be a little less that using 6 volt batteries. It will be a comprimise.
To demonstrate the weight differences between 6volt and 12volt batteries in a 120volt system you would get numbers like the following - 20, 6volt batteries would weight around 1200lbs; 10, 12volt batteries would weigh around 600lbs. As a general rule the more lead you have on board the further you can travel, so the 600lb pack would travel less than the 1200lb pack in the same vehicle.
Actual distances traveled between the two types of packs can vary as they relate to the whole car, not just to the weight of the battery pack. A lighter car will also go further than a heavy car (i.e. a Porche 914 with 10, 12volt batteries will travel the same distance, maybe more than, a Chevy Blazer with 20, 6volt batteries). Weight IS important.
To get ahold of the EVs components that would help me get to my goal, I contacted a number of EV parts companies to get quotes and to talk to them about my ideas and to get their input. Decisions were made, parts ordered and money sent off. One thing that I did not do yet was to order the batteries as they are one of the last things to go in the car. You will need to know the size of the individual batteries to plan their layout in the car and to help with the other component layout design.
Since I was going to convert this car myself (and I had absolutly no knowledge on the subject) I took a class from one of the EV parts suppliers (Electro Automotive) in conjunction with some great folks at Solar Energy International (SEI), on converting a gas car to electric so I would have some experience to draw on. I am also involved with my local chapter of the Electric Auto Association and can draw on it's members knowledge base.
Sometime in the not to distant future I plan on putting down how I did my conversion and include some pictures of the car in it's various stages of construction.
Please check back in about a month or so when I expect to update this section.
This is an open area. Very open.
I would like to get involved with racing and showing the car like many other EV drivers do. I also want to use it to educate the public and help promote the EV as a viable means of transportation.
I'll let you know as time goes bye what's up.


This is a survey in English, Spanish, French, and German of the experience of people with HIV in receiving treatment for HIV from their physicians. It is being done in collaboration with thebody.com, a leading international source of patient-focused, high-quality information on HIV and its treatment. The survey explores mental and behavioural characteristics of the patient and the physician in interaction and its relation to survival with HIV infection and health-effective medical practice.
An evidence-based policy study on biopsychosocial medical practice and how it is best configured to meet the needs of people with acute and/or chronic illness.
A study exploring the comprehensive medical needs of people with HIV at all stages of living with HIV with or without overt illness. The study aims to determine an evidence-base for an integrated model of medical practice that is the most health-effective feasible, as a model for similar research in other complex illnesses.
A study to develop a scientifically valid measure of illness-status. This measure is used in case-formulation, the benchmarking of personalised medical outcomes, the measurement of a clinician's medical effectiveness, and as an index for the purposes of medical governance.
A study to determine which components of clinicians' behaviours are important in delivering health-effective outcomes in medical practice, including the technical, interpersonal, and organisational and how to measure them best.
A study to determine how to measure the job-performance of administrators at various levels of task in order to facilitate the work of the clinicians in delivering health-effective medical services and in helping patients achieve meaningful outcomes, including in conflict-resolution.
A study to specify the necessary methods and techniques in analysing performance-data and how this can be translated efficiently and meaningfully to non-specialist governance groups for the purpose of medical audit and maintenance of medical-service standards.


Pag Island is an island in the north-Dalmatian archipelago, third largest in Kvarner, situated between Kvarneric and theVelebit Channel, with a northwest-southeast extension.The south-western coast of the island is low, and the north-western is steep and high: the Pag Bay (with the large Caska Cove) and Stara Novalja Bay; the southeast of the island features three capes. The climate is Mediterranean.
No surface water streams are found on the island; there are springs near Metajna, Novalja, Povljane and Pag. Most of the island is rocky; smaller areas are covered with Mediterranean shrubs.
The old folk tradition has been partly preserved: tunes (following the same melody, the type of singing known as na kanat), both the heroic and the love ones, traditional dances (po starinski, po paski, the ring of Pag) in Pag and Novalja (po naski). Traditional arts of the island are the stitched lacework of Pag (the lacework school was founded in 1906) and the crochet lacework of Novalja. Beside it the scenic view are marvelous.


Koa Prep is a basketball school that helps kids get into a better college and extend their playing career. We accomplish this through transformational teaching, total college basketball player preparation and best in class fitness training.
Jimmie's playing career truly began after being cut from the Piccowaxen Middle School team in 8th grade. He was 6'3″ at that time and uncoordinated. When his parents asked what he wanted to do, he responded, "To become the first pick in the NBA Draft out of High School!" They responded, "Here are your three rules: don't get in any trouble around the house, don't get more than two C's on your report card, and if you are not going to give 100%, get on the bus and come home." That allowed Jimmie to dream and more importantly, fall in love with the process of becoming a professional athlete. To read more, click here.
Robert is a DC native that graduated from Walt Whitman High School and grew up in a basketball household. He attended Towson University, and was highly involved on campus in the community and served as the vice president for the Boxing club. Robert began his basketball coaching career in 2011 as head coach at High Road High School and in 2012 served as an assistant JV coach at Bethesda Chevy Chase High School (BCC). During the off-season, Robert took head coaching roles in various summer leagues. In 2013, he began coaching AAU for Adidas Uprising and trained multiple high major student-athletes. He is currently the head basketball coach at Herbert Hoover middle school. To read more, click here.
Tony grew up loving and playing sports. His first memory of competitive sports was a 10U club soccer team, he wasn't the worst player, but definitely bottom third on the team. Fast forward eight years (and a sport change later) there were a dozen division 1 players including the Maryland Gatorade State Player on that squad. He was a late bloomer, Tony did not have any scholarship offers for baseball until late June after he already graduated high school. He accepted an offer to play baseball at UMBC, and transferred to Florida Gulf Coast University after his first year in college. To read more, click here.
Evan Sirkey's basketball experience is robust, a local product, he played for Quince Orchard High School's team and accumulated an impressive winning percentage as the starting point guard for their varsity squad. Upon graduation in 2010, he attended Towson University studying sports management with a minor in business administration. Evan decided to play and star on the club team at Towson, instead of pursuing full-time college athletics. Upon graduating from Towson he began his coaching career at his alma mater, Quince Orchard High School. He was the assistant coach for the junior varsity and varsity level for two seasons. To read more, click here.


Got CE and National Patent Certificate, Trapezium Grinding Mill got good reputation with our customers from Australia, US, UK, Spanish and other countries. Trapezium Mill adopts our patented technologies, which are trapezium working surface, flexible connection, roller linked pressure boost, etc. It has reached the advanced international level of powder making equipment manufacturing. Trapezium Grinding Mill is mainly consists of main frame, speed reducer, powder concentrator, induced draught fan, dust collector, piping device, integrator, and motor, etc. The whole grinding mill line include Jaw Crusher, Bucket Elevator, Mill Deceleration Machine, Vibrating Feeder, Main Frame, Blower, Powder Concentrator, Powder Collecting System, Piping Device, and Bag Deduster.
With the impeller adjusting device brings more convenience. The clearance between housing and powder concentrator's blade front end also effects the fineness of the final product.The patent technology enables adjust the clearance more convenience.
2. The final technical data are subject to the operation manual along with the machine.
Note: The final technical data are subject to the operation manual along with the machine.