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Using Descriptor Cutoffs and Multiparameter Optimization for Preparation of CNS Targeted Libraries
Disorders of the central nervous system (CNS) have been constantly puzzling the global health research community due to their plurality, diversity, and, above all, intractability. The human brain is an extremely well-protected organ, which is undoubtedly beneficial to us; however, this complex security system turns up to be a double-edged sword. It is hard to damage the brain. It is not any easier to cure it.
The most significant factor that constrains the discovery of new CNS drugs is the limited blood-brain barrier (BBB) penetrability. More than 98 % of small-molecule drugs do not cross BBB, whereas larger molecules essentially never succeed [1]. Thus, increasing BBB-targeting efficiency is one of the key issues in the design of novel CNS-active medications. Recent advances in CNS drug research rest upon medicinal chemistry [2-4] and nanotechnology-based approaches [3] to go through the BBB.
To optimize the study of potentially CNS-active compounds, researchers attempt to define the physicochemical characteristics of the successful CNS drugs and derive the favorable selection rules. Numerous reviews and statistical studies (see, e.g., [4] and references therein) aim to systematize available BBB permeation data, extract correlations, and suggest strategies on choosing the working drug.
The main parameters that determine a drug permeability include the molecular weight (MW) of a compound, its topological polar surface area (TPSA), charge, and lipophilicity. The latter is usually characterized by the calculated octanol-water partition coefficient (ClogP), as well as by its value at physiological pH = 7.4 (ClogD). Overall, CNS-targeted drugs appear to have high lipophilicity and low flexibility, they have fewer hydrogen-bond donors (HbD < 3) and acceptors (HbAc < 7), reduced molecular weight (150 – 400 Da), fewer formal charges (particularly, negative charges) and lower polar surface area (TPSA ≤ 65 Å2). The exact cut-off values for each of these parameters make up the subject of continuous search, elaboration, and discussion in the scientific community [1,2,4-18].
In most cases, to explain and predict CNS-related pharmacokinetic properties, one needs to solve a complex multi-parameter puzzle, taking into account not only values for individual physicochemical parameters but also considering their interplay. A review of the multivariate screening methods and their application is given in [4,19]. Among the most widely employed techniques are the CNS multiparameter optimization (MPO) [17] and the "Golden Triangle" rule [18,20].
Fig. 1. Multiparameter optimization approach comprises six physicochemical parameters
Fig. 2. The "Golden Triangle" rule utilizes the correlation between MW and lipophilicity
The former method implies the simultaneous estimation of the set of six parameters, namely: MW, TPSA, ClogP, ClogD, HbD, and the acid-base dissociation constant, pKa (Fig. 1). The algorithm returns the MPO desirability score, a number from 0 to 6, which may serve as a reference point for CNS drug design ideas. As a rule, the threshold value of MPO score ≥ 4 identifies the potential CNS-active compounds [17].
The latter approach – the "Golden Triangle" rule – involves joint estimation of molecular weight and lipophilicity ClogD of potential drugs. In fact, the limit of ClogD depends on MW [18]: greater lipophilicity corresponds to lower MWs, resulting in a triangle shape of the graph (Fig. 2) for acceptable drug-like compounds [20]. Considering this correlation may provide better predictions than treating the parameters separately.
Life Chemicals follows the most up-to-date criteria to offer its collection of compounds with desired CNS properties. The Life Chemicals CNS Screening Library comprises over 9,900 small organic molecules, carefully singled out from the database using the optimal threshold values for the main physicochemical parameters. Fig. 3 illustrates the resulting distributions and the calculated MPO desirability score.
To prevent the failure in BBB transport we additionally optimize the number of S, Cl and N atoms in the CNS-targeted compounds, ensure the absence of quaternary ammonium groups and allow not more than one carboxylic acid group [1]. All the compounds are subject to PAINS and toxicophore filters.
Please visit our Website or contact us at orders@lifechemicals.com for more information.
Fig. 3. Distribution of the main physicochemical parameters and calculated MPO score
in the Life Chemicals CNS Library
[1] Pardridge W. M. Blood–brain barrier delivery. Drug Discovery Today. 2007, 12 (1/2); 54–61.
[2] Pajouhesh H., Lenz G. R. Medicinal chemical properties of successful central nervous system drugs. NeuroRx., 2005, 2; 541–553.
[3] Vlieghe P., Khrestchatisky M. Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery. Medicinal Research Reviews, 2013, 33(3):457-516.
[4] Rankovic, Z. CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure. Journal of Medicinal Chemistry, 2015, 58(6), 2584–2608.
[5] Banks, W. A., & Greig, N. H. Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide. Future Medicinal Chemistry, 2019, 11(6):489-493.
[6] Didziapetris, R.; Japertas, P.; Avdeef, A.; Petrauskas, A. Classification analysis of P-glycoprotein substrate specificity. J. Drug Targeting, 2003, 11, 391−406.
[7] Hansch C, Leo A.J. Substituent constant for correlation analysis in chemistry and biology. New York: Wiley, 1979.
[8] Desai, P. V.; Sawada, G. A.; Watson, I. A.; Raub, T. J. Integration of in silico and in vitro tools for scaffold optimization during drug discovery: predicting P-glycoprotein efflux. Mol. Pharmaceutics, 2013, 10, 1249−1261.
[9] Ghose, A. K.; Herbertz, T.; Hudkins, R. L.; Dorsey, B. D.; Mallamo, J. P. Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery. ACS Chem. Neurosci., 2012, 3, 50−68.
[10] Van de Waterbeemd, H.; Camenisch, G.; Folkers, G.; Chretien, J. R.; Raevsky, O. A. Estimation of blood−brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J. Drug Targeting. 1998, 6, 151−165.
[11] Hitchcock, S. A.; Pennington, L. D. Structure−brain exposure relationships. J. Med. Chem.. 2006, 49, 7559−7583
[12] Hitchcock, S. A. Structural modifications that alter the P-glycoprotein efflux properties of compounds. J. Med. Chem.,2012, 55, 4877−4895.
[13] Mao, F., Ni, W., Xu, X., Wang, H., Wang, J., Ji, M., & Li, J. Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs. Molecules, 2016, 21(1), 75.
[14] Ilardi, E. A., Vitaku, E., & Njardarson, J. T. Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery. Journal of Medicinal Chemistry, 2014, 57(7), 2832–2842.
[15] Smith, B. R., Eastman, C. M., & Njardarson, J. T. Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures. Journal of Medicinal Chemistry, 2014, 57(23), 9764–9773.
[16] Wager, T. T., Chandrasekaran, R. Y., Hou, X., Troutman, M. D., Verhoest, P. R., Villalobos, A., & Will, Y. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes. ACS Chemical Neuroscience, 2010, 1(6), 420–434.
[17] Wager, T. T., Hou, X., Verhoest, P. R., & Villalobos, A. Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties. ACS Chemical Neuroscience, 2010, 1(6), 435–449.
[18] Waring, M.J. Defining optimum lipophilicity and molecular weight ranges for drug candidates molecular weight dependent lower logD limits based on permeability. Bioorg. Med. Chem. Lett., 2009, 19, 2844–2851.
[19] Zerroug, A., Belaidi, S., BenBrahim, I., Sinha, L., & Chtita, S. Virtual screening in drug-likeness and structure/activity relationship of pyridazine derivatives as Anti-Alzheimer drugs. Journal of King Saud University – Science, 2019, 31, 595–601.
[20] Johnson T. W., Dress K. R., & Edwards, M. Using the Golden Triangle to optimize clearance and oral absorption. Bioorg. Med. Chem. Lett., 2009, 19, 5560-5564.
1 September 2020, 12:11 Svitlana Kondovych Computational Chemistry


text:
When did Stevie Wonder perform at Madison Square Garden?
Does Stevie Wonder still perform live?
Who did Stevie Wonder open for?
What year did Stevie Wonder open up for the Rolling Stones?
What was the 1972 Rolling Stones tour called?
Does Stevie Wonder have twins?
When is Stevie Wonder's full of Toys Benefit Concert?
Is Stevie Wonder going on tour in 2022?
Stevie Wonder live at Madison Square Garden, Sep 26, 1986 at Wolfgang's.
Will Stevie Wonder tour in 2022?
Unfortunately there are no concert dates for Stevie Wonder scheduled in 2022.
Wonder continues to record and perform; though mainly occasional appearances and guest performances, he did do two tours, and released one album of new material, 2005's A Time to Love.
Who opened for the Rolling Stones in 1972?
9. The Rolling Stones/Stevie Wonder (1972)
Wonder has had a decade of prominence and a long string of hit records that closely parallel the Stones's success story. But he has not been completely satisfied with his position as curtain‐opener for the English rock group. "Sure," he says, "it's been one of the events in my life that I'll never forget.
Will Stevie Wonder ever perform again?
there are currently no upcoming events.
16 June 1972 2 shows Denver Stevie Wonder
18 June 1972 Bloomington
19 June 1972 Chicago
20 June 1972 2 shows
How many concerts did Stevie Wonder have?
Songs in the Key of Life Tour
End date November 24, 2015
Legs 3
No. of shows 44 in North America 44 in Total
Box office $41.7 million
Stevie Wonder concert chronology
The Rolling Stones American Tour 1972
The Rolling Stones American Tour 1972, also known as the "Stones Touring Party", shortened to S.T.P., was a much-publicized and much-written-about concert tour of the United States and Canada in June and July 1972 by The Rolling Stones.
Did Van Halen ever open for the Rolling Stones?
Van Halen were already kings of the hard-rock heap by the time they embarked on their Fair Warning tour in mid-1981, and they concluded the mostly sold-out trek with a two-night victory lap opening for the Rolling Stones.
No, actually it's not true." The 64-year-old, real name Stevland Morris, is already dad to eight kids ranging in age from 1 to 39, according to various reports. "The truth is we're going to have a wonderful daughter, born in December. Her name is going to be Nia, which is 'purpose," the soul star explained.
Did the Rolling Stones play at Madison Square Garden in 1972?
Revisiting The Rolling Stones' blistering performance of 'Brown Sugar' at Madison Square Garden in 1972. The Rolling Stones' U.S. tour of 1972 was a momentous moment in music history.
Read our cover story on Halsey, Trent Reznor and Atticus Ross here. Stevie Wonder will take the stage Dec. 18 at his 23rd Full Of Toys benefit concert at the Microsoft Theater in Los Angeles. The event was last held on December 9, 2018 at the Staples Center in Los Angeles.
Is Stevie Wonder's Show worth seeing?
Stevie Wonder's show is worth seeing. You will not regret it, because this talented person will make you experience unforgettable emotions, help you forget about all your problems and immerse you in the fantastic world of music for one nigh. NOT YOUR INTERESTED? WE HAVE WHAT YOU NEED!
Stevie Wonder tour 2022 announced: This article is part of Billboard's 2022 Grammy Preview issue, which features the artists, themes and trends that will define the awards season. Read our cover story on Halsey, Trent Reznor and Atticus Ross here.
How many times has Stevie Wonder won the Grammy Awards?
With 25 wins out of 74 nominations, Wonder has been in the winner's circle many times; he is one of only four artists (along with Frank Sinatra, Paul Simon and Taylor Swift) to win Album of the Year three times, and the only one to do so with three consecutive albums (Innervisions, Fulfillingness' First Finale and Songs in the Key of Life).
How much is a doxle puppy?
Is Busch Gardens Williamsburg doing Howl-O-Scream 2020?

redpajama_set_name: RedPajamaCommonCrawl


During the recent UK Parliament Week and Children in Need Day, Andrew visited Marshlands Primary School to speak to pupils.
Andrew said, "Marshlands Primary actually visited the Houses of Parliament earlier this year. I was happy to hear that they enjoyed the experience and that they decided to take part in Parliament Week. As mentioned before, the goal of this initiative is to engage young people with politics and the history of our democracy. I was very impressed with the pupils' depth of knowledge and their excellent questions.
"I really enjoyed the visit and was glad to take part in the school's Parliament Week activities.
"Thank you to Marshlands Primary for a wonderful visit."


Has numerous small yellow flowers in the summer, which really attract the bumblebees. Will tolerate varied conditions, from sun to semi – shade and dry soil to wet sunny areas. This shrub keeps a uniform look without any pruning. Will spread by underground roots.


text:
Thermo Fisher Scientific Announces $1.5 Billion Offering of Common Stock
WALTHAM, Mass., Aug. 7, 2017 /PRNewswire/ -- Thermo Fisher Scientific Inc. (NYSE: TMO) announced that it has commenced an underwritten public offering of $1.5 billion of its common stock. Thermo Fisher also intends to grant the underwriters an option for a period of 30 days to purchase up to $225.0 million of additional shares of its common stock. All of the shares in the offering are to be sold by Thermo Fisher.
Thermo Fisher intends to use all of the net proceeds of the offering to fund a portion of the consideration payable for its acquisition of Patheon N.V. (NYSE: PTHN), including the repayment of indebtedness of Patheon N.V. to be assumed by Thermo Fisher. As announced in a separate press release issued today, Thermo Fisher now expects to complete the transaction around the end of the third quarter of 2017, subject to the satisfaction of customary closing conditions, including the receipt of applicable regulatory approvals and completion of Thermo Fisher's tender offer to acquire all of the issued and outstanding shares of Patheon N.V. The offering is not conditioned upon the completion of the acquisition of Patheon N.V.
Goldman Sachs & Co. LLC is acting as lead book-running manager for the offering. BofA Merrill Lynch and Citigroup are acting as joint book-running managers.
The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed or as to the actual size or terms of the offering.
The offering is being made pursuant to an effective registration statement on Form S-3, as amended by the post-effective amendment thereto (including a prospectus), filed with the U.S. Securities and Exchange Commission (the "SEC"). Prospective investors should read the prospectus forming a part of that registration statement and the preliminary prospectus supplement related to the offering and the other documents that Thermo Fisher has filed with the SEC for more complete information about Thermo Fisher and this offering. These documents are available at no charge by visiting EDGAR on the SEC website at www.sec.gov. Alternatively, Thermo Fisher, the underwriters or any dealer participating in this offering will arrange to send you the prospectus if you request it by calling Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at 1-866-471-2526 or by email at prospectus-ny@ny.email.gs.com; BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd floor, Charlotte, NC 28255-0001, Attention: Prospectus Department, or by e-mail at dg.prospectus_requests@baml.com; or Citigroup, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or telephone at 1-800-831-9146.
This press release shall not constitute an offer to sell or the solicitation of an offer to buy the shares of common stock, nor shall there be any offer, solicitation or sale of the shares of common stock in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements about the company's intended use of proceeds and the expected closing of the acquisition of Patheon N.V. These statements involve a number of risks and uncertainties that could cause actual results to differ materially from currently anticipated results, including risks and uncertainties relating to capital markets conditions and completion of the offering. Additional important factors and information regarding Thermo Fisher's business that could cause actual results to differ materially from those indicated by such forward-looking statements are set forth in the prospectus, which is on file with the SEC and available in the "Investors" section of our website under the heading "SEC Filings," and the documents incorporated by reference into the prospectus and prospectus supplement. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if circumstances change and, therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.
Karen Kirkwood
Investor Contact Information:
Ken Apicerno
E-mail: karen.kirkwood@thermofisher.com
E-mail: ken.apicerno@thermofisher.com


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Short-Track Roundup: USAC National Sprint Car Series prize fund to top $1 million
By Mike Kerchner
The USAC National Sprint Car Series has increased financial rewards to its competitors for the 2012 campaign.
All USAC National Sprint Car Series events, with 47 on the calendar, will pay a minimum of $5,000 to win and $500 to start. The Eastern Swing will offer $6,000 to win and $600 to start.
Six events will pay $10,000 or more to win, making 2012 one of the richest seasons in history, with more than $1 million in purses for the series. USAC will also reward the top 10 in owner points entering each racing event with an additional incentive worth approximately $200 per night.
King and his court
Their legendary father, Brent Kaeding, might be known in racing as the king of California, but Tim and Bud Kaeding were the kings of Las Vegas on March 8.
Older brother Bud Kaeding won the USAC West Coast 360 Sprint Car Series feature at the DirtTrack at Las Vegas Motor Speedway, while younger brother Tim Kaeding followed him up by scoring his seventh career World of Outlaws Sprint Car Series victory in the nightcap at the half-mile dirt track.
The World of Outlaws moved on to California, where Joey Saldana became the fifth different winner in five features this season on Saturday night.
Bloomington Speedway changes hands
Bloomington (Ind.) Speedway owners Mike and Judy Miles have turned over the reins of the quarter-mile dirt track to Bloomington Speedway Partners, LLC.
The new ownership group includes local Bloomington businessman Jack Craig, veteran sprint-car racing family Dan and Brenda Roberts, Bruce Leer (owner of Leer Motorsports) and Dale Dillon, principal of Dillon Racing.
Back in the win column
Preston Peltier, who won the 2010 Pro All-Star Series national Late Model championship but went winless in 2011, got back to victory lane in Saturday night's opener for the PASS South division at South Carolina's Dillon Motor Speedway.
C. E. Falk earned $10,500 for winning the Late Model season opener at Virginia's South Boston Speedway. . . . Danny Wood and Dustin Morgan claimed Lucas ASCS Sprint Car Series triumphs at Arizona's Cocopah Speedway. . . . Don Shaw (Late Model) and Randy Brown (modified) were dirt winners at Las Vegas Motor Speedway. . . . Colby Wiesz and Brett Rollag claimed sprint-car victories during the Silver Cup at California's Silver Dollar Speedway. . . . Stewart Friesen was a winner in three-quarter midgets inside the Dunkin Donuts center in Providence, R.I.
The World of Outlaws Late Model Series added to its schedule with races at I-77 Raceway Park in Ripley, W.Va., on May 27; North Central Speedway in Brainerd, Minn., on July 14; and Iowa's Independence Motor Speedway on Aug. 6. . . . The USAC National Sprint Car Series has added a Sept. 7 event at I-30 Speedway in Arkansas. . . . The Must See Xtreme Sprint Series is expanding to include a supermodified series for the first time this season.
More From More Racing
How Meyer Shank, HPD Pulled off Rolex 24 Repeat
Rolex 24 at Daytona Was IMSA's Giant Leap Forward
Rolex 24 at Daytona Results: Meyer Shank Repeats
Wehrlein Scores Formula E Sweep in Saudi Arabia
Why Sports Car Driver Ratings are a Murky Business
Corvette Z06 GT3.R Breaks Cover at Rolex 24
Readers React to Week's Biggest Racing News


Africa is the world's second largest and second most-populous continent (the first being Asia in both categories). At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 6% of Earth's total surface area and 20.4% of its total land area. With 1.2 billion people as of 2016, it accounts for about 16% of the world's human population. The continent is surrounded by the Mediterranean Sea to the north, both the Suez Canal and the Red Sea along the Sinai Peninsula to the northeast, the Indian Ocean to the southeast and the Atlantic Ocean to the west. The continent includes Madagascar and various archipelagos. It contains 54 fully recognised sovereign states (countries), nine territories and two de facto independent states with limited or no recognition. Africa's average population is the youngest amongst all the continents; the median age in 2012 was 19.7, when the worldwide median age was 30.4. Algeria is Africa's largest country by area, and Nigeria is its largest by population. Africa, particularly central Eastern Africa, is widely accepted as the place of origin of humans and the Hominidae clade (great apes), as evidenced by the discovery of the earliest hominids and their ancestors, as well as later ones that have been dated to around seven million years ago, including Sahelanthropus tchadensis, Australopithecus africanus, A. afarensis, Homo erectus, H. habilis and H. ergaster—with the earliest Homo sapiens (modern human) found in Ethiopia being dated to circa 200,000 years ago. Africa straddles the equator and encompasses numerous climate areas; it is the only continent to stretch from the northern temperate to southern temperate zones. Africa hosts a large diversity of ethnicities, cultures and languages. In the late 19th century European countries colonised almost all of Africa. Africa also varies greatly with regard to environments, economics, historical ties and government systems. However, most present states in Africa originate from a process of decolonisation in the 20th century. African nations have attempted to cooperate through the establishment of the African Union, which is headquartered in Addis Ababa.
Aggregate Industries, a member of LafargeHolcim, is a company based in the United Kingdom with headquarters at Bardon Hill, Coalville, Leicestershire. Aggregate Industries manufactures and supplies a range of heavy building materials, primarily aggregates such as stone, asphalt and concrete, to the construction industry and other business sectors. Aggregate Industries also manufactures and imports cement, and provides a range of aggregate-associated goods and services, these include the manufacture of masonry and reconstructed stone items for construction industry and domestic applications, the manufacture of pre-cast concrete items, the supply of ready mixed concrete, design and project management consulting, and resurfacing contracting services. Aggregate Industries operates more than 60 quarries in the UK and has several bases throughout mainland Europe and Scandinavia. Its clients operate in a range of services including construction, aviation, education, horticulture, road building, housing, power and energy and rail.


Quickly finds local maxima (peaks) or minima (valleys) in a noisy signal.
This function quickly finds local peaks or valleys (local extrema) in a noisy vector using a user defined magnitude threshold to determine if each peak is significantly larger (or smaller) than the data around it. The problem with the strictly derivative based peak finding algorithms is that if the signal is noisy many spurious peaks are found. However, more complex methods often take much longer for large data sets, require a large amount of user interaction, and still give highly variable results.
This function attempts to use the alternating nature of the derivatives along with the user defined threshold to identify local maxima or minima in a vector quickly and robustly. The function is able to correctly identify the major peaks on a 1.5 million data point noisy sum of sinusoids in under a second as is shown in the example in the code comments.
Please don't hesitate to comment or contact me if you have suggestions about improvements that could be made to this function.
Is there a way to find minima even if they are higher than 0 ???
This worked great and it was super easy to use. Thanks!!!
The function works perfect. But why sel is set default as (max - min)/4? Any reference here? Appreciated.
Thank you. It work very well on my project. I appreciate your work.
Great tool! My only request would be to add an optional output argument that provides error bars for interpolated results.
Does this work for 3D plots?
Thanks! This code was very useful for my purposes. I implemented a C++ version that you can find here: https://github.com/claydergc/find-peaks. Hope it helps!
great code. I needed to include endpoints and exclude them if they appear in the answer, otherwise in some case I get an error: index exceeds matrix dimension.
Otherwise, good code and very useful.
Much less arguments than matlab findpeaks and, nonetheless, much more effective!
Super code. User friendly, works very well.
Great function, thanks! very user friendly and works perfectly.
Great code. Could you please be more specific as to the meaning of input variable 'sel'?
It works very nicely for my problem! Thank you!
@Ezor: 'sel' is a relative value from my understanding.
I'm able to find Maxima, but please let me know how to find Minima?
That's great ! It could have been even better if the variable 'sel' had refered to a relative value between two points instead of an absolute one.
I've been getting this warning about Nargchk for a while now, maybe you can exchange it.
OK, what just happened? Matlab 2015a, and the function "boolean" doesn't exist. You should remove it in favor of the actual boolean operators, or indicate that Simulink is required.
Do you have a PDF with the used equations and citations ?
I need to cite your work correctly.
Hi, Nathanael. Thanks for the code. It's very fast and easy to use. Great code !
Thank you for sharing this function, Is there reference for this method ?
I am new in the MATLAB. How to implement the peakfinder code?
I'm trying the following and is not working. Could you help me on this?
in this case the vector of peaks found for each w has a different size.
Hi, I'm really new to MATLAB. I would like to use your peakfinder routine, which I think is going to do exactly what I want.
I am trying to define an approach for quantifying noise in some spectral data I've taken where contaminants are present. I'd like to use a S/N threshold to define above how many standard deviations my data is contaminant vs. real. I suspect real peaks in my spectral data will be hundreds of standard deviations above the threshold (compared to a standard) and contaminants will be maybe 10s of times above it (compared to a standard).
I downloaded your routine but I'm not sure how to modify it to read in a specific spectral data file, then find the peaks in a noisy region in that spectrum, then calculate the average and standard deviation of those peaks.
Hi Nathanael! This is very useful function. Thanks for posting it. I noticed a couple of bugs in the code. They are quick fixes.
1) Looks like a typo on line 139, instead of nargin < 6 you have it as 5.
2) In the while loop on line 205, there are conditions where the variable 'tempLoc' and 'tempMag' are not declared (E.g. line 256).
Although I am new in matlab but using this peakfinder code. This is fantastic code. But I need this code in C language for that I tried to convert but not able to convert.
so please if any of you have this code in C, may I get it.
This code saved me hours. I had a peak-finding problem that the newest version of findpeaks took care of nicely with the MinPeakProminence parameter. Unfortunately, my colleagues at another university only had access to a previous version of the function. After tweaking some of the parameter values in the function call, all went nicely.
This function works well most of the time. However, in the case when the data only has one or two extrema, the code assume the function is monotonic and assumes the points are the end points and then excludes them if 'includeEndpoints' is false, when it should be returning the peak. A good test case is a quadratic.
Just adding a comment after using this function for a few months (thanks again!!!) - it would be useful to add a test at the beginning checking whether there are NaN's in x0, which causes the function to fail (without an error, ie. peaks are returned, but they don't work). Now that I know I simply remove them before running the function and add them again, but it took me a little while to notice that something was wrong and understand why.
Good one. Nice work. Thanks.
Excellent. Worked well for my application.
@Nathanael Yoder: With the new version from 13.8.2014 all peaks in my data are found. Thanks again.
@Frank I believe the function works as intended with the current indexing methodology. By using the same index (ii) for traversing both the valleys and the peaks, the function has to come down at least sel between each peak and two peaks can't be right next to each other. That said, please email me if you have an example of where you feel it does not work and I'd be happy to take a look.
Great. It works fine for ecg peak detection.
Very useful, thanks! For my application I was trying to find the average of peaks from some experimental data that had some outliers, so I used trimmean() on the output of this function.
is there a way to have peakfinder return only ONE peak -- the highest -- from x0?
Is there any code to find minimums (instead of peaks)?
Exactly what I needed. Works well with mid-infrared spectra. Thanks!
@Jakob Are you sure you are calling this function? Line 98 in this peakfinder is: dx0 = diff(x0); % Find derivative.
Hello, does anybody know how to replicate these peaks into a grayscale image.
I've tried several approaches to detecting peaks in noisy data; this one worked best, and is exceptionally fast. Very nice work!
How should I cite this code?
I am very new at this. How do I make this code find multiple peaks?
I am a matlab newbie,I have x and y as vectors, I plotted them in MATLAB and now I need to detect the peaks and also find the corresponding peak locations. How can I use this code in my case?
Hello,i also have a problem with this code when i input the data under 1200 sampling frequency it doing well can detect all the peak points,but when i tried with other data under different sampling frequency sometimes it only can give me like half points some are missing,i don't know how to attach the image file,but can give me any help?
Hello all, I have a problem with this code when my SNR is less 1.9 dB I CANT DETECT MY PEAKS OF INTEREST. What i want to know is it not possible to detect peaks at such noisy conditions ???
Joanne: That kind of error-message typically arises when Matlab does not know where the command resides (or when you misspelled it). Make sure that any m-file you wish to run are either in the current directory, and/or in your Matlab-path. If you have a separate folder for non-builtin m-files (such as peakfinder) that you wish to use, you can add that folder to the Matlab-path with the 'addpath' command, and put those m-files there.
very quick and supportive response from the author. The output issue as listed above is due to my misunderstanding of the varargout. The other issue may also results from the Matlab setting rather than the code. Thank you, Nate.
Hi, I find this routine very good and useful. However, for my problem I would need the start-end information about each peak so I could select just the peaks and work with them, How can I get this information?
Hi. I need to find peaks in a waveform and calculate the inter-pulse interval and the pulse rate from the position of the peaks. My data are sounds recorded at 24000Hz and saved in .wav files. This code seems to be doing exactly what I want but since I'm a matlab newbie I'm not quite sure how to input my data. Do you have any suggestions?
I hope this is the right place to post this message, otherwise I apologise.
Thanks for catching that Tim. You were exactly right, the redundancy is an artifact from when I preallocated the matrix for speed. However, I essentially replaced this statement with the leftMin variable which is why you got the same results. The end effect is that the second part of that conditional can simply be eliminated.
Thanks again for your help and an updated version with the addition of a user defined threshold should be available shortly.
The second part, x(ii) > peakMag(end), is rather strange, since peakMag(end) will ALWAYS be equal to zero, since peakMag was preallocated with zeros. I guess this is a remainder from the time before you preallocated peakMag for speed.
The strange thing is that the results luckily stay exactly the same, which is good but strange at the same time. There is probably some redundancy in the code.
In any case, your method was more or less what I was looking for. Just need to make some small adaptations to it for my purpose, of course leaving all credits to you. Thanks!
fantastic code, very effective even with highly noise data.
notably, it might be worth including an histogram based thresholding for a more optimal threshold selection.
Does anyone know of a comparable code that finds extrema in 2D or 3D data?
The bugs were fixed quickly. Thanks Nate!
I was happily using peakfinder until I had severe trouble with a dataset beginning with repeated values.
1) The first call returns a wrong result (Loc1 = 2, Peak1 = 49).
2) The second call returns all three peaks, but the last one appears twice (Loc2 = [2 5 8 8].', Peak2 = [54 46 39 39].').
I hope these issues can be fixed as peakfinder works promisingly fast.
A minor suggestion: if the input is a row vector the output should be a row vector, too.
Added ability to quickly estimate the location and magnitude of the extrema between data points for regularly spaced data using quadratic interpolation. The function continues to work for irregularly spaced data. Default is no interpolation.
Fix bug related to a missing equality comparison (thanks Nina Merkle!) and fix inconsistency when the endpoints are not treated as extrema (thanks Solomon Grant!).
Added an optional boolean to exclude the endpoints since, as pointed out by Peter Cavanagh, most definitions of local extrema do not include them. By default the endpoints are included to maintain backward compatibility.
Removed redundancy (thanks Tim) and added thresholding option (thanks Femi).
Updated the error checking on the threshold level.
Added support for monotone increase/decreasing functions and empty inputs. Thanks again to Andres for the debugging help.
Fixed problems with repeated initial values, repeated final values, and other directional issues. Thanks to Andres for his help finding and debugging these problems.
Fixed example and error checking code. Thanks to Jiro Doke for catching my mistakes.
Updated algorithm to make it slightly faster.
Updated code to make it slightly faster.


text:
Conservatives strike deal with the DUP: experts react
School of Politics and International Studies news Tuesday 27 June 2017
Dr Stuart McAnulla, Associate Professor in Politics has spoken to The Conversation about the Conservative/DUP deal.
Dr McAnulla suggests the money involved in this deal is less likely to worry the Conservatives than the political cost of having to make a deal to reach a slim majority.
Commenting on the financial implications of a £1 billion deal, Stuart believes that "having attacked Labour for offering endless funds from a "magic money tree", the Conservatives will now be asked why money can seemingly be quickly found when it is politically expedient for them."
He highlighted too, that not all Conservatives were on board with this deal with "former Prime Minister John Major warning it could destabilise the Northern Ireland peace process, whilst others argued the Conservatives could have governed as a minority without a formal deal, as the DUP would have been unlikely to vote against them".
Stuart then discussed how the deal has clear benefits for the Conservatives, in particular with DUP backing guaranteed on Brexit and security issues which offers May the possibility of leading Britain through Brexit. However he reminded the reader that in the short-to-medium term this arrangement will also give ammunition to Theresa May's opponents inside and outside the Conservative party.


This initiative is part of the strategy of City of Copenhagen for urban renewal of the neighborhood of St. Kjelds district, covering physical, social and cultural upgrading to address challenges of social housing, unemployment and low living standards. The cloudburst in Copenhagen in 2011 drew the attention of the city to the climate change risks. The Copenhagen Adaptation Plan was prepared and St. Kjelds was selected as the pilot area to build neighborhood resilience and improve urban life for 24,000 residents. The interventions include sustainable storm water management through green solutions on the surface to prevent flooding in the neighborhood; creating greener urban spaces through enhanced bio-diversity and branding of the neighborhood.
The Technical Committee selected the Copenhagen initiative because of the innovation in future-proofing the city with green climate change adaptation solutions at the street level, solutions which are scale-able to city-level and the prospective learning for other cities.


As RE/MAX real estate sales associates, Doug & Marcia can assist you through the entire process of buying a Lake Gaston home or property, starting with the mortgage and continuing right through closing – and beyond. We can help you shop for the best interest rate and terms and, if you wish, suggest mortgage lenders.
Start by obtaining a copy of your credit report and your FICO score and, if necessary, do what you need to do to improve it. The higher your FICO score, the better interest rate you can get from your mortgage lender. You can get this information on-line, or Doug & Marcia can also help you. Contact several lenders and determine which one will give you the best deal.
Once you find an ideal property for sale on Lake Gaston, please feel free to use the Mortgage Calculator below to determine what your payments would be for your loan. This will give you an idea as to how much mortgage you can afford and what your payments will be based on the interest rate and amount of payments calculated.
You must have Java enabled within your browser in order to utilize these calculators. In addition you must have pop-up blockers disabled in order to view the Amortization results - or simply click on the CTRL key while clicking on AMORTIZE.
The calculation above does not take into account any monies that may be required to be kept in escrow for things such as home owners insurance and real estate tax which may be required by some lenders. AMORTIZE will provide a table with principal and interest payments based on the data entered in the table fields.


text:
Ed Morrissey Show
Study: Over 20 debates, Paul attacked Romney's rivals 39 times -- but never once attacked Romney
Allahpundit Feb 27, 2012 3:40 PM ET
Caveat: The study comes from Think Progress. But in case you're inclined to doubt it because of its provenance, note that The Corner's Patrick Brennan also reviewed transcripts from the last seven debates dating back to January 7 and found just one instance of Paul criticizing Romney — and that criticism was brief and mild.
Out: Conspiracy theories advanced by Ron Paul. In: Conspiracy theories involving Ron Paul.
While Paul has freely attacked Romney's top rivals, he has never once attacked Romney…
Paul has gone beyond merely refraining from attacks. He has actively defended Romney on some of his biggest vulnerabilities…
Paul has also run advertisements attacking Romney's key rivals at critical times. He ran hundreds of thousands of dollars in brutally negative ads attacking Gingrich in Iowa. Paul now is using his scarce funds on a television ad attacking Rick Santorum in Michigan, a key state where Paul is a non-factor.
TP's tally of attacks by RP at the debates: 22 on Santorum, eight on Gingrich, four on Perry, four on Cain, one on Bachmann, and a big fat doughnut on Mitt. I can understand why he'd be drawn into slugfests with Santorum, who, as an extremely hawkish social con, is furthest away from Paul on the ideological spectrum within field. But Romney's a natural Paul enemy too: He's an establishment favorite, he paved the way for universal health care with his Massachusetts program, he's considerably more hawkish than Paul, he has pro-choice roots, etc etc etc. Plus, insofar as he's the consummate flip-flopper, he's the anti-Paul; RP could have run a withering campaign against him emphasizing how likely Romney will be as president to shift with the political winds, especially vis-a-vis Paul himself. In fact, if you'd asked me before the debates began whom Paul would spend most of his time attacking, I would have guessed Mitt. What better way for a principled insurgent candidate to gain traction with the conservative base than by beating up repeatedly on a widely distrusted centrist for his betrayals of the cause? And yet … nothing.
I don't think they're coordinating, though — or at least, not formally. Paul's advisors have been candid in interviews in explaining that his goal in running this time is to pile up delegates and gain some influence at the convention, either in terms of input into the party's official 2012 platform or a primetime speaking gig or both. That being so, it's only logical that they'd go easy on Romney. He was and is the likely nominee; the more helpful they are to him, the less resistance there'll be to a convention role for the Paul family, especially since Romney will be nervous about alienated libertarians staying home if he freezes Paul out. RP tried running against the rest of the field in 2008 and got nothing from the establishment as thanks. This time, he's taking a different tack. It's working.
Tags: RON PAUL MITT ROMNEY DEBATE RICK SANTORUM THINK PROGRESS
Uh oh. Ghislaine Maxwell "will no longer fight to keep names of John Does secret"
Boston students freezing in classrooms due to COVID requirements
Americans to Biden: You're focusing on the wrong things, damn it
Rabbi of Congregation Beth-Israel: "Grateful to be alive"
Sinema's courage, Washington hypocrisy, and the politics of rage
China and Iran officially partner up
Texas Dems work around election integrity law as they mail out "hundreds of thousands" of mail-in ballots
If the US-Russian talks aren't dead they're on life support
Jazz Shaw Jan 16, 2022 5:01 PM ET
A poignant reminder: Social media isn't bad – unless we make it so
Dustin Siggins Jan 16, 2022 2:01 PM ET
MLK III family rally in Arizona targeted Sinema over her position on the filibuster
Karen Townsend Jan 16, 2022 12:31 PM ET
Late for your own wedding: Sunday reflection
Ed Morrissey Jan 16, 2022 11:46 AM ET
Kinder, gentler Taliban: All girls, women back to school "soon"
Jazz Shaw Jan 16, 2022 9:31 AM ET
Sunday morning talking heads
Allahpundit Jan 16, 2022 8:01 AM ET
Copyright ©2022 HotAir.com/Salem Media. All Rights Reserved.


text:
NGC 3544 = NGC 3571 ist eine Balken-Spiralgalaxie vom Hubble-Typ SBa im Sternbild Becher südlich des Himmelsäquators.  Sie ist schätzungsweise 159 Millionen Lichtjahre von der Milchstraße entfernt.

Das Objekt wurde am 8. März 1790 von dem deutsch-britischen Astronomen Wilhelm Herschel entdeckt.

Weblinks
 SIMBAD Astronomical Database

Einzelnachweise

Balkenspiralgalaxie

redpajama_set_name: RedPajamaWikipedia


text:
Maksim Vladimirovitch Mamine - en russe :  et en anglais :  - (né le  à Moscou en Russie) est un joueur professionnel russe de hockey sur glace. Il évolue au poste d'attaquant.

Biographie

Carrière en club
Formé au HK CSKA Moscou, il débute en junior avec la Krasnaïa Armia dans la MHL lors de la saison 2011-2012. Il commence sa carrière en senior avec le CSKA Moscou dans la KHL en 2014-2015. Lors du repêchage d'entrée dans la LNH 2016, il est choisi au sixième tour, à la cent-soixante-quinzième position au total par les Panthers de la Floride. En 2017, il part en Amérique du Nord et est assigné aux Thunderbirds de Springfield dans la Ligue américaine de hockey. Le , il joue son premier match dans la Ligue nationale de hockey avec les Panthers chez les Blue Jackets de Columbus. Il marque son premier but le 22 février 2018 face aux Capitals de Washington. Durant la saison 2018-2019, il ne parvient pas à s'imposer comme titulaire et retourne au CSKA Moscou. Mamine marque le but décisif lorsque l'équipe remporte la Coupe Gagarine 2019.

Carrière internationale
Il représente la Russie au niveau international. Il prend part aux sélections jeunes.

Trophées et honneurs personnels

Ligue continentale de hockey
 2014-2015 : remporte le trophée Alekseï Tcherepanov de la meilleure recrue.

Statistiques
Pour les significations des abréviations, voir statistiques du hockey sur glace.

En club

| 2011-2012 || Krasnaïa Armia || MHL || 38|| 1|| 4|| 5|| 12|| 5|| 1|| 0|| 1|| 4
|-
| 2012-2013 || Krasnaïa Armia || MHL || 61|| 14|| 15|| 29|| 45|| -|| -|| -|| -|| -
|-
| 2013-2014 || Krasnaïa Armia || MHL || 49|| 11|| 24|| 35|| 14|| 20|| 5|| 16|| 21|| 0
|-
| 2014-2015 || Krasnaïa Armia || MHL || 4|| 1|| 4|| 5|| 2|| 4|| 3|| 4|| 7|| 8
|-
|2014-2015|| HK CSKA Moscou || KHL || 39|| 5|| 5|| 10|| 10|| 14|| 0|| 0|| 0|| 27
|-
|2015-2016|| HK CSKA Moscou || KHL || 48|| 4|| 3|| 7|| 57|| 19|| 1|| 1|| 2|| 14
|-
|2015-2016 || Zvezda Tchekhov || VHL || 5|| 0|| 1|| 1|| 2|| -|| -|| -|| -|| -
|-
|2016-2017|| HK CSKA Moscou || KHL || 42|| 12|| 13|| 25|| 15|| 9|| 2|| 1|| 3|| 2
|-
|2016-2017 || Zvezda Tchekhov || VHL || 4|| 2|| 3|| 5|| 0|| -|| -|| -|| -|| -
|-
| 2017-2018 || Thunderbirds de Springfield || LAH || 32|| 9|| 16|| 25|| 25|| -|| -|| -|| -|| -
|-
| 2017-2018 || Panthers de la Floride || LNH || 26|| 3|| 1|| 4|| 7|| -|| -|| -|| -|| -
|-
| 2018-2019 || Panthers de la Floride || LNH || 7 || 0 || 0 || 0 || 5|| -|| -|| -|| -|| -
|-
|2018-2019|| HK CSKA Moscou || KHL || 25|| 1|| 2|| 3|| 33|| 10|| 2|| 3|| 5|| 4
|-
|2018-2019 || Zvezda Moscou || VHL || -|| -|| -|| -|| -|| 2|| 1|| 1|| 2|| 0
|-
| 2019-2020 || HK CSKA Moscou || KHL || 51|| 10|| 18|| 28|| 31|| 4|| 1|| 2|| 3|| 2
|-
| 2020-2021 || HK CSKA Moscou || KHL || 55 || 15 || 20 || 35 || 27 || 22 || 6 || 6 || 12 || 2
|-
| 2021-2022 || Panthers de la Floride  || LNH || 40 || 7 || 7 || 14 || 13|| 4|| 0|| 0|| 0|| 0
|-
| 2021-2022 || Checkers de Charlotte || LAH || 7 || 2 || 3 || 5 || 2|| -|| -|| -|| -|| -

Au niveau international

| 2015 || align="left"|Championnat du monde junior || 7|| 2|| 3|| 5|| 14|| +3|| align="left"|  Médaille d'argent
|-
| 2018 || align="left"|Championnat du monde || 6|| 3|| 0|| 3|| 2|| +2|| align="left"| Sixième place

Notes et références

Naissance à Moscou
Attaquant de hockey sur glace
Naissance en janvier 1995
Joueur international russe de hockey sur glace
Choix de repêchage du CSKA Moscou
Choix de repêchage des Panthers de la Floride
Joueur du HK CSKA Moscou
Joueur des Thunderbirds de Springfield
Joueur des Panthers de la Floride
Champion de la Coupe Gagarine
Joueur des Checkers de Charlotte (LAH)


text:
package com.sdw.soft.extension.oauth2.server.entity;

import javax.persistence.Column;
import javax.persistence.Entity;
import javax.persistence.GeneratedValue;
import javax.persistence.Id;
import javax.persistence.Table;

import org.hibernate.annotations.Cache;
import org.hibernate.annotations.CacheConcurrencyStrategy;
import org.hibernate.annotations.GenericGenerator;
import org.hibernate.annotations.Index;

import com.sdw.soft.core.annotation.MetaData;

/**
 *
 * @author syd
 */
@Entity
@Table(name="oauth2_client")
@Cache(usage=CacheConcurrencyStrategy.READ_WRITE)
@MetaData(title="oauth2client")
public class Client {

	private String id;

	private String clientName;

	private String clientId;

	private String clientSecret;

	@Id
	@Column(length=40)
	@GeneratedValue(generator="hibernate-uuid")
	@GenericGenerator(name="hibernate-uuid",strategy="uuid")
	public String getId() {
		return id;
	}

	public void setId(String id) {
		this.id = id;
	}

	@Column(length=100 ,nullable=false)
	public String getClientName() {
		return clientName;
	}

	public void setClientName(String clientName) {
		this.clientName = clientName;
	}

	@Column(length=100,nullable=false)
	@Index(name="idx_oauth2_client_client_id")
	public String getClientId() {
		return clientId;
	}

	public void setClientId(String clientId) {
		this.clientId = clientId;
	}

	@Column(length=100,nullable=false)
	public String getClientSecret() {
		return clientSecret;
	}

	public void setClientSecret(String clientSecret) {
		this.clientSecret = clientSecret;
	}

}

redpajama_set_name: RedPajamaGithub


Games freeze as soon as they start. They show one frame and then stop completely.
PCSX2 itself doesn't stop responding or crash.
I installed PCSX2 just through the normal Linux Mint / Ubuntu package repositories with apt-get, no PPA. It says it is version 1.4.0-0.
I've tested Super Monkey Ball Adventure and SpongeBob SquarePants: Battle for Bikini Bottom (both PAL with a European BIOS) through the ISO selector and they both hung on the first frame.
I'm using a proprietary NVIDIA driver: nvidia-384 (version 384.111-0ubuntu0.16.04.1).
I don't know if this is relevant, but in Mint's driver manager, there's a choice between intel-microcode (version 3.20180108.0+really20170707ubuntu16.04.1) and "Do not update the CPU microcode", and the latter is selected.
If there's any other information or screenshots or anything I can provide, I'd be happy to. I really want to get this to work.
Did you install multiarch libraries for 32-Bit support?
(02-02-2018, 12:47 AM)FlatOut Wrote: Did you install multiarch libraries for 32-Bit support?
Strange, it feels like a segmentation fault.
Turns out this is not the case for all games. I just tested The SpongeBob SquarePants Movie Game and it works.
The games that didn't work were both released in the Australia / New Zealand region, but the game that worked was released in Europe. Possibly relevant?
Shadow of the Colossus NA version also works.


"We served a little notice tonight. The cat's out of the bag."
IOWA CITY, Ia. — The match was over for seven, maybe eight seconds, and Austin DeSanto had his hands in the air, basking in the applause from the 8,500 screaming fans. The sophomore transferred to Iowa for moments like this, to wrestle matches like this, to win matches like this.
"That was pretty cool," he said afterward.
No. 3 Iowa defeated No. 13 Rutgers, 30-6, at Carver-Hawkeye Arena on Friday night. The Hawkeyes took eight of 10 matches and scored bonus in three to improve to 8-0 overall and 3-0 in Big Ten competition. The Scarlet Knights fell to 7-4 and 1-2.
It was a workmanlike outing from Iowa on this night. Spencer Lee (125) and Alex Marinelli (165) both scored pins. At 197 pounds, Jacob Warner defeated Matthew Correnti, 6-0, thanks to a four-point tilt during a third-period rideout. Sam Stoll closed the dual with a major decision win at heavyweight. Rutgers received wins from Anthony Ashnault (149) and Joseph Grello (174).
The night belonged to DeSanto, Iowa's mercurial 133-pounder who's ranked eighth in the country by Trackwrestling. He defeated the third-ranked Suriano, 6-4, in the dual's marquee matchup. Suriano, a returning NCAA finalist, took the lead on a second-period takedown and accrued 70 seconds of riding time with a minute left in the third.
But in order to do so, Suriano gave up a pair of stalling calls in the final period. DeSanto added an escape to lead 4-3. Suriano's riding time would have forced overtime, but DeSanto scored a takedown on the edge with 1.5 seconds remaining to secure the biggest win of his career so far.
"I got to my tie," said DeSanto, who improved to 12-1 overall with the win. "He was blocking off with his fingers a little bit. We were going at it. Once I kept getting to that tie, I hit it. Kind of surprised myself a little bit. I need to fire more shots off and do a lot more things."
Once the ref called time, DeSanto stood up and screamed in Suriano's face, an act that cost Iowa a team point. It is the second straight dual that DeSanto has been called for an unsportsmanlike call. He was hit for one last Sunday when he defeated Minnesota's Ethan Lizak.
"I shouldn't have done that," DeSanto said. "It's something we've been working on with Tom and (associate head coach Terry Brands). I just have to stay calmer. I'm calm in the match. I have to stay calmer until I get off the mat.
Brands jumped out of his chair to grab DeSanto and pulled him toward the Iowa bench, where assistant coach Bobby Telford pointed to his own temples. The crowd was in full throat. Brands talked to him before DeSanto walked back to shake hands with Suriano. He said afterward that he and the rest of the coaching staff have worked with DeSanto on containing his emotions.
"What happened out there in that match cannot happen," Brands said. "We're in Carver-Hawkeye Arena and it's dual season, but when tournament time comes around, there are referees that will throw him out. We have to stress the importance of that and his sportsmanship.
This was the part of DeSanto that Brands knew he'd have to iron out when Iowa recruited him in the offseason. DeSanto created a stir in his quarterfinal match against Michigan's Stevan Micic at the NCAA Championships. At the end of a 13-1 Micic victory, DeSanto cartwheeled into an illegal armbar that gained negative attention in wrestling communities.
But the coaching staff asked DeSanto about it during the recruiting process and felt confident enough in their abilities that it wouldn't be an issue when it matters most. The rest of the team embraced DeSanto almost immediately.
"He'll be like, 'Can I beat this guy?'" said Lee, who was crucial in recruiting DeSanto to Iowa, "And we'll say, 'Austin, you can beat anybody on any given day. We believe in you with all our heart.' He gets all fired up, but then he goes out and he's got to wrestle his match. He's wrestling his match and he wins and it's like his mind goes, 'I did it!' The emotions just take over.
Friday's victory elevated DeSanto firmly into the All-American conversation. He proved that his high pace continues to be perhaps his most-effective asset in his still-growing wrestling repertoire. During the second half of the dual, a young fan came to media row and asked for a pen, then took it to DeSanto and asked for his autograph.
DeSanto smiled. This is why he transferred to Iowa, for moments like this in front of a crowd like this, glow sticks and all. And it's why Brands and Co. brought him here — to win matches like this.
*Iowa was deducted a team point for unsportsmanlike conduct following 133-pound match.


The BGJ over the years has grown to be a valuable archive of seminal articles on Gestalt theory and practice, some of which are perennially in demand from students and training institutes.
Until recently, a number of back issues were out of print and popular articles from them could only be obtained from Caroline Hutcheon in Bristol who would make copies to order.
The entire archive is now accessible as digital downloads for a small fee per item. These however are the 20 most asked for articles from the previously out-of print issues and together they comprise a cross-section of some of the best writing in Gestalt therapy over the past two decades.


text:
Posts Tagged 'iTunes'
Jimi Hendrix app launched to provide a complete 'Hendrix Experience'
Jimi Hendrix: The Complete Experience is now available as a free app for the iPad, iPhone or iPod Touch.
The app is being offered as "Your backstage pass to explore and learn all about the music, life and career of the legendary Jimi Hendrix".
Launched to coincide with what would have been the guitarist's 69th birthday on November 27, the app enables fans to explore interactive chapters of Hendrix's legacy through text, images and video.
Listeners can browse through the full collection of Hendrix's albums, read about documentaries, live performances and other films about Hendrix, and also download music content directly from iTunes.
Watch a video about the app and read the full story HERE…
How important are 'oldies' songs to you? Vote in our poll below:
Tags:app, App Store, baby boomers, digital magazine, digital music magazine, Electric Lady Studios, Experience Hendrix, Experience Music Project Museum, iPad, iPhone, iPod Touch, iTunes, Jimi Hendrix, Jimi Hendrix: The Complete Experience, music magazine, oldies, oldies music magazine, over-50s, over-50s music magazine, Sh-Boom, Sh-Boom Magazine, Sh-Boom! digital magazine
Posted in Blues, Rock, Singer-songwriters, Sixties, Sound & Vision | Leave a Comment »
Peggy Lee albums available digitally for first time
EMI is releasing 22 of Peggy Lee's classic albums as digital downloads for the first time. Some of the albums are currently out-of-print on CD.
She recorded 592 tracks for Capitol Records between 1942 and 1952, and between 1957 and 1972.
21 of the 22 albums are from her second stint at Capitol. They include I Like Men! (1959), I'm A Woman (1963), Is That All There Is? (1969) and a restored version of her final album Peggy Lee at Basin Street East: The Unreleased Show (1972).
Sh-Boom! is now available as a digital magazine. You can read a sample of the first issue here (best viewed in full-screen mode).
It's FREE TO JOIN, and we'll send the magazine direct to you when published.
Tags:1950s, Capitol Records, digital magazine, digital music magazine, I Like Men!, I'm A Woman, interactive magazine, Is That All There Is?, iTunes, music magazine, music-based social network, oldies, oldies music magazine, online music community, over-50s, over-50s music magazine, over-50s social network, Peggy Lee, Peggy Lee at Basin Street East: The Unreleased Show, pensions, retirement, Sh-Boom, Sh-Boom Magazine, Sh-Boom! digital magazine, The Fifties
Posted in Compilations, Easy Listening, Fifties, Jazz, Sixties | Leave a Comment »
Gerry Rafferty dies at age 63
Scottish singer-songwriter Gerry Rafferty – whose hits included the 1978 classic 'Baker Street' and 'Stuck in the Middle with You' with Stealers Wheel – has died at the age of 63 after a long illness.
Comedian Billy Connolly paid tribute to his friend and former singing partner: "Gerry Rafferty was a hugely talented songwriter and singer who will be greatly missed. I was privileged to have spent my formative years working with Gerry and there remained a strong bond of friendship between us that lasted until his untimely death.
"Gerry had extraordinary gifts and his premature passing deprives the world of a true genius".
Gerald "Gerry" Rafferty was born on 16 April 1947 into a working-class family in Paisley, Scotland, the son and grandson of coal miners.
Inspired by his Scottish mother who taught him Irish and Scottish folk songs as a boy, and heavily influenced by the music of The Beatles and Bob Dylan, he started to write his own material.
In the mid-1960s, Rafferty earned money for a time busking on the London Underground – an experience that is said to have inspired his song 'Baker Street'.
In 1969, he became the third member of folk-pop duo The Humblebums which featured Billy Connolly and Tam Harvey. Harvey left shortly afterwards and Rafferty and Connolly went on to record two acclaimed albums for Transatlantic Records, including singles such as 'Shoeshine Boy' and 'Her Father Didn't Like Me Anyway'.
Connolly and Rafferty decided to go their separate ways in 1971 and Transatlantic Records signed Rafferty as a solo artist. He enjoyed critical success but wasn't able to break into the charts. Then, in 1972, he teamed up with his old friend Joe Egan to form Stealers Wheel and success finally came with 'Stuck in the Middle with You'. The track was later used prominently in the 1992 movie Reservoir Dogs.
After Stealers Wheel split up in 1975, legal disputes meant that Rafferty was unable to release any new material for three years. In 1978, he recorded his second solo album, City to City, which included 'Baker Street', the song with which he is most identified. The single reached No. 3 in the UK and No. 2 in the United States.
His follow-up album Night Owl (1979) reached Number 9 on the UK album chart and Snakes and Ladders (1980) peaked at Number 15. But subsequent studio albums between 1982 and 2000 could not match the success of these albums and Rafferty spent his later years fighting alcoholism and depression.
In November 2010, he was admitted to hospital in Bournemouth, suffering from liver failure. He died at home on 4 January 2011, of liver disease.
Tags:Baker Street, Billy Connolly, digital magazine, digital music magazine, Gerry Rafferty, iTunes, Joe Egan, music magazine, over-50s, over-50s music magazine, over-50s social network, pensions, Reservoir Dogs, retirement, Sh-Boom, Sh-Boom Magazine, Sh-Boom social network, Sh-Boom! digital magazine, Stealers Wheel, Stuck in the Middle with You, The Humblebums, Transatlantic Records
Posted in Folk, Pop, Rock, Seventies, Singer-songwriters, Sixties | Leave a Comment »
Debbie Harry and Blondie to release new album 'Panic of Girls' in 2011
Debbie Harry and her band Blondie have revealed that they plan to release a new album next year. Titled Panic of Girls, it will be Blondie's ninth studio album and their first collection of new material since The Curse of Blondie in 2003.
According to Blondie drummer Clem Burke, the band has already recorded about 35 new songs in Woodstock, New York – with 14 of the songs expected to make it onto the album. He hints that some of the surplus songs may be released via the Internet.
It's the first time the band has recorded outside Manhattan since Automamerican, which was produced in Los Angeles in 1980.
"We tried to make the recording process as organic as possible," says Burke. "We tried to stay away from programming as much as we could because the last album, The Curse of Blondie, had a lot of programming on it. So in the spirit of Woodstock, we just kept going in the studio and playing."
He says everyone in the band contributed songs, although Debbie Harry – who turned 65 in July – wrote most of the lyrics. The album title, Panic of Girls, is a line from one of her new songs.
Burke says Blondie has been previewing a handful of the new songs during its summer tour dates – including the tracks 'What I Heard', 'The End' and 'Mother'.
Debbie Harry admits she's pleased to have some new songs to perform on stage. "I feel a definite urge to not just do old songs," she says. "I really want to have a voice in the present, so I'm very happy that this is all going on because we've been stuck in a position for a couple of years where we weren't recording.
"It really is awful having to go out and do the same old songs over and over again, although it's not completely awful because you get a great response from the audience. They're happy to hear the songs."
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Tags:Automamerican, baby boomers, Blondie, Debbie Harry, digital magazine, digital music magazine, Eighties, iTunes, music magazine, oldies, oldies music magazine, over-50s, over-50s music magazine, Panic of Girls, pensions, retirement, Sh-Boom, Sh-Boom Magazine, Sh-Boom! digital magazine, The Curse of Blondie
Posted in Eighties, Nineties, Pop, Punk, Rock, Seventies | Leave a Comment »
Engelbert Humperdinck new album Released…
Engelbert Humperdinck has released a new album, titled Released, which was recorded in Los Angeles with Australian record producer Paul Wiltshire who has previously worked with artists such as The Backstreet Boys and Delta Goodrem.
Wiltshire and Engelbert's son and manager Scott Dorsey were executive producers of the 11-track album which sees Engelbert stamping his own touch on current songs such as 'We've Got Tonight'.
Wiltshire produced Engelbert's first-ever iTunes hit, 'Tell Me Where It Hurts', which is also be featured on the new album.
Engelbert says he was thrilled by the success of 'Tell Me Where It Hurts' on iTunes. "In the old days, you put out a single and promoted it in person," he says. "Now with iTunes it's instantly all over the world. It's quite exciting."
Engelbert, who turned 75 last May, admits he will forever be best known for his version of the ballad 'Release Me', which was recorded over 44 years ago (and was responsible for keeping The Beatles' 'Strawberry Fields Forever' from reaching Number One in the UK).
He feels it's "an honour" to be so closely associated with the song. "I've recorded so many albums in my life, but because it was my signature and because it was my first song and because it went to number one around the world and gave me a global career immediately, it's the only song they sing in my face at airports. It just goes to show the power of one song."
During his 45-year career, the 'king of romance' has always been synonymous with smooth ballads. But he doesn't like being classed as a 'crooner'. "No crooner has the range I have," he says. "I can hit notes a bank couldn't cash. What I am is a contemporary singer, a stylised performer."
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Tags:crooner, Delta Goodrem, digital magazine, digital music magazine, Engelbert Humperdinck, iTunes, music magazine, over-50s, over-50s music magazine, Paul Wiltshire, pensions, retirement, Sh-Boom, Sh-Boom Magazine, Sh-Boom! digital magazine, The Backstreet Boys, The Beatles
Posted in Christmas, Easy Listening, Pop | Leave a Comment »
'The Dave Clark Five – The Hits' finally released on CD
Good news for Dave Clark Five fans who haven't got into downloading music yet. The compilation album The Dave Clark Five – The Hits – which has been available as a download on iTunes since March – is finally about to be released on CD.
The 27-track retrospective – which includes the previously unreleased track 'Universal Love' and the often overlooked 'Til The Right One Comes Along' – will be released as a CD in the UK on October 13, 2008.
The album comes complete with a booklet containing many previously unseen photos of the band.
In 1964, the Dave Clark Five were regarded as the biggest challengers to The Beatles when their single 'Glad All Over' knocked the Fab Four's 'I Want to Hold Your Hand' off the top of the UK charts after a six-week stay at Number One.
The Tottenham quintet were also the first 'British Invasion' band after The Beatles to achieve huge success in the United States – including a record 18 appearances on the Ed Sullivan Show and six sold-out US tours.
Between 1963 and 1967, The Dave Clark Five had 22 hits in the UK and 24 in America – with memorable singles like 'Glad All Over', 'Bits and Pieces', 'Because', 'Can't You See That She's Mine' and a remake of Bobby Day's 'Over and Over' – all of which are included on The Dave Clark Five – The Hits.
Full track listing:
1. Do You Love Me
2. Glad All Over
3. Bits And Pieces
4. Can't You See That's She's Mine
5. Everybody Knows (I Still Love You)
6. Don't Let Me Down
7. Any Way You Want It
8. Wild Weekend
9. Catch Us If You Can
11. I Like It Like That
12. Reelin' And Rockin'
13. Over And Over
14. Come Home
15. You Got What It Takes
16. Try Too Hard
17. Everybody Knows
18. I'll Be Yours My Love
19. Nineteen Days
20. Look Before You Leap
21. Til The Right One Comes Along
22. All Night Long
23. Good Old Rock 'n' Roll Medley
24. Sha Na Na Hey Kiss Him Goodbye
25. Here Comes Summer
26. Put A Little Love In Your Heart
27. Universal Love
Tags:1960s, baby boomers, Dave Clark Five, digital magazine, digital music magazine, iTunes, music magazine, oldies, oldies music magazine, over-50s, over-50s music magazine, over-50s social network, Sh-Boom, Sh-Boom Magazine, Sh-Boom! digital magazine, The Beatles, The Sixties
Posted in Pop, Sixties | Leave a Comment »
Sir Cliff Richard slams sound quality of downloads
While more and more over-50s are starting to get the hang of downloading music tracks from online retailers such as iTunes, Sir Cliff Richard says he'll never be one of them.
He complains that the sound quality of downloaded music is inferior to the "unbeatable" sound from CDs.
"It's very hard to beat a CD," he told the BBC News website. "I like putting six CDs in the machine and playing them for two or three days."
The 67-year-old pop legend also revealed that his favourite format is the 12″ vinyl album because, he said, you can read the sleeve "without getting a magnifying glass."
Sir Cliff is hoping to top the UK singles chart again this weekend with his latest single 'Thank You For a Lifetime'. If he manages to reach the top spot, it will be his fifteenth Number One.
Most significantly, though, he'll become the first artist ever to score Number One hits across six decades.
However, Sir Cliff admitted that achieving a Number One hit in 2008 "did not have the same cachet" as topping the chart with 'Living Doll' in 1959 – at the start of his career.
"In those days, when you released a single, it was potentially a million-seller," he told the BBC. "That's completely out of the question now, because people just don't buy singles."
Many of Sir Cliff's loyal fans are still buying singles though. Some are reportedly buying up hundreds of copies of his new CD single in an attempt to make sure it gets to Number One.
Even if Sir Cliff fails to top the charts again, it's unlikely that his existing landmark achievement – scoring number one hits across five decades – will be beaten by any other artist. After all, these days many artists don't even last five years, let alone five decades.
Tags:Cliff Richard, iTunes, music magazine, over-50s, Sh-Boom
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