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Home>Basketball> Jimmy Butler Reportedly "Ghosted" The Rockets After Max Offer
Jimmy Butler Reportedly "Ghosted" The Rockets After Max Offer
Maddie Meyer/Getty Images
How are you going to do the Rockets like that?
Jimmy Butler has proven himself to be one of the most entertaining players in the entire NBA and he is also one of the most intense. Butler has a reputation for wanting to do things his way and sometimes this rubs people the wrong way. Butler has had tension with his teammates in the past but this hasn't made him any less attractive to prospective teams.
During the offseason, Houston Rockets were heavily pursuing Butler although he chose the Miami Heat. According to Tim McMahon of ESPN, the Rockets thought they had a real shot at ending up with Butler but in the end, they were essentially left on read.
"Look, the Houston Rockets wanted to pay Jimmy Butler the four-year max and he ghosted them," McMahon explained on Brian Windhorst's The Hoop Collective Podcast. "They thought they had them and he left them hanging. They had trades lined up, I don't know the teams (or) the destinations, but they had trades lined up for (Clint) Capela and (Eric) Gordon. They were ready to pay Jimmy Butler. They really liked their chances and then suddenly, Jimmy had other thoughts.
So far, Butler's decision has worked out for both the Rockets and the Heat. The Heat are among the best teams in the Eastern Conference while the Rockets are thriving with Russell Westbrook and James Harden at the helm.
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BASKETBALL Jimmy Butler Reportedly "Ghosted" The Rockets After Max Offer


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Q: Uniformly Bounded invertible linear operators have their inverses with norms uniformly bounded Let $\{T_n\}$ be a series of bounded linear operators on $X$ to $Y$, where $X,Y$ are Banach space. Suppose that $T_n$ is invertible, and $\sup_n ||T_n||<\infty$. Can we show that $\sup_n ||T_n^{-1}||<\infty$?

A: Think about the operators $T_n = 1/n$ on $X = Y = \mathbb{R}$.

redpajama_set_name: RedPajamaStackExchange


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Q: How to get the value that is passed to Runtime.getRuntime.exit(value) in a JUnit test case I have to write a Test case in JUnit for a Class lets call it C1 which internally calls Runtime.getRuntime.exit(somevalue).
The class C1 has a main method which accepts some arguments and the creates a CommandLine and then depending on the passed arguments does the specific tasks.
Now all tasks after executing call a Runtime.getRuntime.exit(somevalue). The somevalue defines whether the task was executed successfully (means somevalue is 0) or had errors (means somevalue is 1).
In the JUnit test case of this I have to get this somevalue and check whether it is the desired somevalue or not.
How do I get the somevalue in the JUnit test case.

A: You can override security manager to catch the exit code, if you use a mocking framework it would be more concise:
@Test
public void when_main_is_called_exit_code_should_be_1() throws Exception {
    final int[] exitCode = new int[1];
    System.setSecurityManager(new SecurityManager() {
        @Override
        public void checkExit(int status) {
            exitCode[0] = status;
            throw new RuntimeException();
        }});

    try { main(); } catch(Exception e) {}

    assertEquals(exitCode[0], 1);
}

public static void main() {
    System.exit(1);
}


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"They were about to break our heads with the baton. Do you think they would care about our health?"
Date and time: December 14, 2021 10:30
Location: Uzunbodzhak to Avcilar
Pushback from: Bulgaria
Demographics: 34	person(s), age: 5 - 57 years	, from: Syria, Iraq
Minors involved? Yes
Violence used: beating (with batons/hands/other), kicking, exposure to air condition and extreme temperature during car ride, sexual assault, threatening with guns, theft of personal belongings
Police involved: 3 Bulgarian border police officers in sage green uniforms, 6 Bulgarian soldiers with green camouflage uniforms, 1 black Bulgarian border police land rover, 1 Bulgarian big military truck, 1 Bulgarian military jeep
Taken to a police station?: no
Was the intention to ask for asylum expressed?: Yes
On December 14, 2021 between 10 and 11 am, the respondent and 32 other people on the move (POM) were pushed back from Uzunbodzhak, Bulgaria to Avcilar, Turkey.
The respondent is a 47-year-old male from Syria who was travelling in a group of 34 people consisting of Syrians and Iraqis. Among them there were 3 women and 7 minors. Four of them were between 5 – 9 years old while three of them were between 10 – 17 years old.
On December 13, 2021 at around 10 pm the group started their journey from Edirne to the Bulgarian border by a 40 minute drive on mostly unpaved roads in a van and by a 30 minute footwalk afterwards. Close to a river at the Turkish-Bulgarian border fence the group waited while hiding between the reed in the water for approximately three hours. After that the POM crossed the river and climbed a small hill and crossed into Bulgarian territory through a hole in the border fence their smuggler, who had accompanied the group until this point, had previously cut.
At around 2 am of December 14, 2021 the 34 POM, including one road guide, crawled through the hole in the fence and started running. The respondent explained that the area had many unpaved roads used by Bulgarian border police which patrol the border. He noticed cameras which he referred to as "night vision cameras" mounted every 3 meters on top of the 5 meters high, barbed border fence.
After gathering again after 20 – 30 minutes of waiting for everyone to arrive, the group started to walk fastly through the mountains in order to not be noticed. The POM walked about 8 km continuously in 4 hours. "No one can walk on paved roads in Bulgaria. We were even afraid every time we found unpaved roads on our way" which is why they walked between trees in the mountain forest on slippery and wet ground. Their envisaged destination was a meeting point close to a village which the respondents friend identified as Lesovo, Bulgaria.
Their smuggler told them that after the 10 km walk to this place they would be picked up and driven to Sofia. The respondent didn't know about further details how the transport of 34 people at once should be organized: "I don't know – that was the deal".
The group never got to the envisaged meeting point because they were intercepted on their way when they had to cross an empty big open area without trees. Suddenly the lights of two cars flashed and the road guide contested "That's it, they got us".
The cars approached the group at around 6 am on December 14th, 2021 and were parked in front and behind the group. The seven officers who left the cars started screaming at the POM, threatened them with guns, and continuously kicked and beat all members of the group for about 15 minutes. Children were crying and although the respondent couldn't see whether women were physically assaulted as well, he witnessed how minors were kicked in front of his eyes. The beating and kicking was random, in all parts of the body.
The guns they were threatened with were described as riffle guns, identified as AK-47 and small police guns, identified as Beretta M9, and recognized by the pictures below.
Beretta M9
Three of the seven officers were wearing sage green uniforms with "police" written on their backs, identified as Bulgarian border police uniforms and carrying the "small police guns" identified as Beretta M9. The remaining four officers were identified as Bulgarian soldiers by their green camouflage uniforms with the Bulgarian flag. The respondent recognized the pictures below.
Bulgarian border police uniforms
Bulgarian army uniform
The vehicles used were a black land rover with "police" written in the front, as used by the Bulgarian border police, and a green old military jeep, which the respondent identified as a Merced-Benz G-Class Armoured jeep. This vehicle is used by the Bulgarian army.
Bulgarian Border Police – Discovery Landrovers
Mercedes-Benz G-Class Armoured Jeep
After the initial physical assault on of officers identified ad Bulgarian border police took pictures of the POM all together with his phone and started to ask questions in Turkish and English. The officers spoke Bulgarian amongst them. One of the minors was forced to gather their belongings and continuously kicked in order to do this faster. After that, he was beaten with a baton and forced to sit down again.
The group was taken away all their personal belongings and had to put their phones and money in a separate black bag which afterwards was put in the black Bulgarian border police land rover. The respondent had about 150 Euros and estimates that the officers took about 1700 Euros from the whole group. After that the group was searched and forced to undress except for their underwear one by one. Although the women were not forced to undress they were searched by male officers and touched in their sensitive areas. The minors also had to remove their clothes. This took about 40 minutes.
"They were searching every part of our clothes like they were digging for gold and we were freezing from the cold weather".
The officers took the money, phones, power banks and shoes, and food and water that they were carrying. Only pants and shirts were returned, the rest was stolen. This took place in the early morning around 7 am.
Following that a big, olive green military truck arrived and the POM were hit with batons by the officers in order to get in the trunk of the car quickly. The respondent recognized the vehicle as a ZIL-131 as pictured below.
ZIL-131 military truck
All 34 people were loaded into the 2 x 3 metre trunk of the truck and the group was having a hard time breathing inside the narrow and dark space. Inside the truck were two officers wearing Bulgarian army uniforms. They drove on unpaved roads for approximately 3 hours in a reckless way.
"They kept moving around and we really started breathing hard. We were locked inside like we are chicken. […] We felt at some moment that the truck was about to flip and fall. We were so scared!".
At the point of arrival at the border fence, they only met the Bulgarian border police officers in the black land rover. One of them opened a door in the fence, as pictured below, and one by one the POM were pushed back to Turkish territory between 10 and 11 am on December 14, 2021. The area around the location of pushback was dominated by forests and mountains.
Border fence with door
Except for the minors, all POM were barefoot. "We walked in the middle of the forest and we really didn't know where we were. We were hungry and thirsty." They walked for almost 4 hours until they arrived at the small village Avcilar where they asked for water and food and were provided help by a local. By using a smartphone the POM could contact a friend via facebook who called the smuggler. He sent two vans which arrived after 4 more hours and the group went partly back to Edirne, partly to Istanbul.
The desire to ask for asylum was expressed when the officers first encountered the group. No water, food, or medical assistance was provided.
No fingerprints and only collective photos were taken before the group was searched.

redpajama_set_name: RedPajamaCommonCrawl


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Q: Using two individual check buttons in tkinter with the same value In this code I'm trying to use these two checkbuttons, that should be active/inactive, completely independent of one another, but it doesn't work as expected:
from tkinter import *

root = Tk()

enable = {'jack': 0, 'john': 0}

def actright(x):
    print(enable.get(x))

for machine in enable:
    l = Checkbutton(root, text=machine, variable=enable[machine], onvalue=1, offvalue=0,
                    command = lambda: actright(machine))
    l.pack(anchor = W)

root.mainloop()

When either "jack" or "john" is checked, they both activate/deactivate at the same time. I assume this is because they are initiated at the same value, but is there a way for them to be independent, but also still both be initiated at "0"?
Aside from my main question I do have a sub topic: Regardless of how many times the buttons are checked they still return "0", However the "onvalue" is set to 1 for the checkbutton, so shouldn't they alternate between returning 1 and 0 instead?

A: You need a dictionary with IntVars (or even the checkButtons) in it.
Then you need the usual lambda machine=machine (classic gotcha when initializing widgets in a loop).
So the result will be something like that:
from tkinter import *

root = Tk()

enable = {'jack': 0, 'john': 0}
checkvalues = {}

def actright(x):
    print(x,  checkvalues[x].get())

for machine in enable:
    myvar = IntVar()
    myvar.set(enable[machine])
    checkvalues[machine] =myvar
    l = Checkbutton(root, text=machine, onvalue=1, offvalue=0, variable = myvar,
                    command = lambda machine=machine: actright(machine))
    l.pack(anchor = W)

root.mainloop()

A: Adding to Eric Levieil's excellent answer; if you'd like to print the binary only, be sure to define actright() without printing x, or you will end up printing the name in the dictionary associated with the value.
def actright(x):
    print(checkvalues[x].get())

(Note: not enough reputation to comment yet)


Is your faith a furnace, running at extreme temperatures at all times?
I think there are questions we can ask ourselves when our faith feels more fickle than normal. Here are some that I think of when my fire is burning a little low.
1. Have I forgotten that God's love came first, without me doing anything to earn or achieve it?
It's so easy to get disoriented in reference to God. We might feel like we got into his good graces through our good behaviour, or good choices.
When we realize that God's love is first, preeminent and superabundant, we can see remember that it is not a love that only sees the good things we do. It is a love that encompasses and enfolds us in our weakness as well.
2. Am I allowing myself to be fed with good food?
It's important to make a distinction between dryness, which God permits to allow us to grow in faith, and lukewarmness, which a lack of spiritual fervour on our part. The latter is on us.
One thing I look at when I am feeling a little less fervour in my faith is, what am I doing to foster my faith? Am I allowing myself to be fed, or am I starving myself spiritually?
Speaking to two, starting with the Sacraments, it is sad that my friend that I mentioned, by skipping Sunday Mass, was refusing to take the most obvious medicine for his "dryness", our Lord's very presence!
We can choose to feed our souls by praying and meditating on Jesus' life, death and resurrection. This really can strengthen our faith.
Related: Check out an interview I did with Msgr. Greg Smith on pursuing holiness.
3. Am I putting up actual barriers?
Anytime we make peace with sin we are allowing a barrier in our relationship with God. The example above about deliberately missing Mass places a significant barrier between us and God.
There are big barriers (mortal sins) and less-big barriers (venial sins), but they are real barriers. We need to look hard and see if we are placing them in our relationship with God and weakening our faith.
Have you surrendered any parts of your life to sin? Have you given up the fight in some area? Have you decided that you are so wretched that even God can't deliver you from some evil?
Kick that stuff to the curb!
God desires sin to be eradicated from our lives, with his grace and help. Let us look deeply within ourselves and seek his mercy frequently. Let not sin or pride be a barrier to receiving the mercy of God again and again.
4. Am I seeking the input of good Christian friends?
Who do I speak about my faith with? When it's strong, or not as strong, God places people in our lives who we can draw wisdom and counsel from.
Who do you look up to as an authentic disciple of Christ? Draw near to them and your faith will be strengthened.
5. Have I become too inward focused?
This one is less obvious, but there is a missionary dimension to Catholic faith, for ALL Catholics. The message we have received is meant to be spread widely, and if we allow it to become our private matter, something we never seek to promote to others, then we lose out on something of our faith.
Conversely, engaging in a missionary effort will build your own faith up. The evangelist is the first beneficiary of evangelization.
If you can help out in an Alpha, or small group faith study, or some other deliberate evangelization, you will grow in faith.
We can also add under this category the effort to address the corporal needs of our neighbor, i.e. care for the poor, the elderly, the infirm, the lonely, etc.
6. Am I letting my own weakness trump God's immeasurable strength?
Does that resonate with you? I think it's worthy of reflection whenever we are down.
What do you do when your faith is weak? Does the above help, or do you have other ways of fanning the flame?


Hi. I just bought boat this weekend and it came with a 150 G2 HO(love how this motor runs). I downloaded the iLink app and tried to connect to the motor but it will not connect. Or simply does see/recognize the connection. Coming from a Mecury with vessell view, I really like the app feature.
Can anyone provide me some advice on how to connect? There is not a feature in the app(that I can find) to connect.
Did you or your dealer connect the iLink module hardware to the network backbone?
Look for the app eLink and see if that works. There were two different versions of apps depending on the hardware - Evinrude iLink and Evinrude E-Link.
If you have software version PGF479_A3, the password should be EvinrudeiLINK. Version PGF479_A1 is the old password, EvinrudeELink.
The iLink module to connect the engine to the app does not come standard with the G2 engines. It is an accessory item like gauges are and purchased separately.


Meet in the parking lot south of HomeGoods. Bring seedlings, plants, seeds or garden supplies to trade with other gardeners. Trades only please, no sales.
Egg Hunts start at 10am for 4 and under and ages 5 and older will start shortly after. In addition to the Easter Egg Hunt, the Easter Bunny will be here and there will be face painting and activities for kids.
Beat the Blahs – Shop, Sip, Stroll, Dine, Discover . . .
Celebrate the Season at Uptown!
The Gig Harbor Lion's Giving Trees are around Uptown again. In Partnership with the Cheney Family Boys & Girls Club and the FISH food bank, the Gig Harbor Lion's Club has organized this giving opportunity to provide gifts for children in our community. Select a tag from a tree and return the unwrapped gift to the same location where it will be picked up and distributed to a child in need. Some shops are even offering discounts when purchasing an item for the tree. Giving trees are currently located at the following Uptown businesses: The Foundry, Gameday Sports Shop, Kitsap Credit Union, Massage Envy and van der Veen Jewelers.
Join the Chabad Jewish Center of Pierce County for the annual Gig Harbor Public Menorah Lighting. Enjoy singing, dancing, traditional Latkes, Dreidels, doughnuts and more. Fun for the entire family!
Celebrate the season of giving by helping assemble and deliver Thanksgiving baskets. November 20th and 21st. Thanksgiving food donations accepted.
Bring starts, bulbs, seeds, gardening tools or anything gardening to trade with fellow gardeners. No plant sales please.
Visit gigharborfilmfestival.org for more information.
Up to 50% off sale items at participating merchants!
Participating merchants include: Bloom, Chico's, the Foundry, frankie, Gameday Sports Shop, the Garden Room, J.Jill, Jos. A Bank, Talbots and van der Veen Jewelers.
Relay for Life has moved their event to Uptown this year. Please join us on May 5, 2018 from 10am – 3pm to support a cure for cancer.
Meet at the pond at 10am for an Easter Egg Hunt and Easter Bunny Visits.
The Chabad Jewish Center of Pierce County will host the public Menorah Lighting at Uptown. This celebration is open to the public and will include singing and dancing, traditional Latkes, games and food. It will be fun for the entire family!
Come trade plants, starts, cuttings, seeds, etc as well as unwanted gardening tools/equipment with other gardeners from around the region. For more information, see the Gig Harbor Plant Swap on Facebook.
Featuring 1,000-2,000 hand-blown glass pumpkin crafted by local glass artisans. Wander through a dazzling array of one-of-a-kind glass pumpkins in a variety of colors, shapes, sizes and price ranges. These glass art pumpkins are perfect for the autumn season yet beautiful enough to display year-round. Come pick the perfect pumpkin for yourself or as a gift. Sponsored by the Tacoma Glassblowing Studio.
visit gigharborbeerfestival.com for more information.
Meet at the fountain near Bloom for the Egg Hunt and Easter Bunny meet and greet.
Stand up to the weather and say yes to the possibilities. . . a warm welcome, or cozy sweater, a funny toy or savory meal. Uptown is your antidote for NW gray, your cure for cabin fever. Take a break and come revel in the pleasures of Uptown. It's all here, ready when you are.
Shop, sip, stroll, dine . . . discover Your style, your Uptown.


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text:
The cavalry are coming
Writing the past: Outlander, Bonnie Prince Charlie and the Jacobites
Digitisation: An internship in photography and butterflies
By Dr Fraser Hunter
Principal Curator of Iron Age and Roman collections
Be wary if you're around Hadrian's Wall this summer – it's just received heavily-armoured cavalry reinforcements, and they're on the watch for wandering Caledonians.
Earlier this summer my colleague Jim Wilson and went for a canter along the Wall, installing some of our star Roman objects in an innovative exhibition which runs the length of Hadrian's frontier, from Wallsend in the east to Carlisle and on down the coast to Maryport. Called Hadrian's Cavalry, it's going to be a blockbuster this summer, and we're pleased to be part of it.
Why is it so good? Cavalry were the showmen of the Roman army. They were paid much better than ordinary frontier infantrymen, and they lavished this wealth on impressive armour and harness for themselves and their horses. As a result, the exhibits are amazing. The show features old friends, such as one of our parade helmets from Newstead and another from Ribchester (on loan from the British Museum), but also material from German and French museums, and private collections, never seen in Britain before.
Brass parade helmet from Newstead.
Part of a bronze horse-mask (chamfron) in the form of the goddess Minerva (from a private collection, © Minerva Heritage 2017).
Most spectacular are the ornate helmets and masks worn in tournaments which recreated great mythical battles such as Greeks versus Amazons. Highly ornate shield bosses, leg protectors, and chest armour, all covered with protective images of the gods – this has to be seen to be believed. Horses were also finely turned out, with gleaming harness and ornate face masks (chamfrons). As well as our own leather chamfron from Newstead and its close cousin from Vindolanda, there are bronze chamfrons and other harness fittings on show.
Amazingly ornate and well-preserved leather chamfron from Newstead, with holes for the eyes and flaps which fitted over the ears.
Putting together one of these exhibitions is a major challenge – spreading it over ten venues makes it greater still. Lots of different bits of the museum get involved. For this loan our registrars sorted out the complex and challenging logistics, the conservators checked it was all safe to travel, the curatorial side discussed with the borrower what might fit their stories best, and our assistant curators packed them for safe travel. The packing is a work of art in itself – it should be exhibited alongside the objects!
The chamfron packed for its travels.
The exhibition is not just about the military. There's a nice little display in Corbridge which looks at the horse in wider Roman culture, and our terracotta horse from Newstead is on holiday there. It's one of a pair which once pulled a model chariot, showing the range of uses which horses had in the Roman world. But it's the cavalry who dominate this show – as they did 1800 years ago, a strike force on Rome's northern frontier capable of ranging far and wide into hostile territory, and armed to the teeth.
The Newstead terracotta horse.
So if you're in the Wall area this summer, it's worth a look. But the big event is a Roman cavalry charge – the first since the end of Roman rule around AD 400 – when a turma, 30 Roman cavalry horses, will take to the field in Carlisle on 1-2 July. Book your tickets now – it'll be a sight to inspire, or terrify, depending which side you're on …
- Posted 30th June 2017
Other posts by this author.
Chasing the carnyx, from Scotland to the Sahara
Post by Dr Fraser Hunter
Disentangling early Christianity on the Traprain Treasure
A century of silver: the Traprain Treasure on its hundredth birthday
Rebuilding Roman silver: a fantastic find from Fife
Researching the first archaeologist in Egypt
By all accounts, the story of archaeology in Egypt begins in the mid-1880s with the excavations of William Matthew Flinders…
By Dr Margaret Maitland
My student placement at National Museums Scotland
Having the opportunity to complete a placement with National Museums Scotland was a dream come true for me. I am…
By Emily Raup
The most controversial lemon-squeezer in history?
Have you ever thought of a lemon squeezer as controversial? Prior to my student placement at National Museums Scotland, this…
A microscope that tells the story of a remarkable woman
There are a number of these microscopes in our collections, but what makes this example stand out is that we…
By Julie Gibb


Download and share this infographic by right clicking and selecting "save image as" to download as a JPEG image or by selecting the link below to download as a PDF file. You also can download the companion flyer, which you can print and post in your workplace. Encourage your employees and colleagues to use the bedtime calculator to make sure they get 7 or more hours of sleep on a regular basis.


text:
Sat, Nov 26, 2011 page2
Air force takes delivery of three Super Puma choppers
Staff Writer, with CNA
Taiwan took delivery of three EC-225 Super Puma search-and-rescue helicopters that it ordered last year from Eurocopter, air force officials said yesterday.
The new aircraft were delivered to the air force's Chiayi airbase yesterday, the officials said.
After being assembled and tested, the Super Pumas will join the Air Force Seagull Rescue Squadron on July 1 next year.
Workers inspect a EC-225 Super Puma search-and-rescue helicopter at the air force's Chiayi airbase yesterday.
Photo: CNA
The squadron currently operates 17 S-70 helicopters, most of which are more than 20 years old, officials said.
The Super Puma has a five-blade main rotor, incorporating a new airfoil shape to reduce vibration levels, allowing it to carry up to 24 passengers. It is also equipped with de-icing systems, movable stretchers, life rafts, pop-out floats, life monitoring devices and automatic flight control systems.
The officials said the all-weather, all-topography aircraft would be a big boost to the rescue squadron when it is carrying out search-and-rescue missions at night and in bad weather, or in high mountains or over rough seas.
The helicopters can also be used to airlift supplies to isolated areas and to transport sick and injured people to hospital.
The EC-225 was developed by Eurocopter in 1998 and Taiwan placed its order for three at a cost of US$110 million in February last year, with an option for 17 more.
The air force sent pilots, crew and ground service personnel to Eurocopter's European base for training earlier this year.
The EC-225 is 19.5m long, has a maximum takeoff weight of 11.2 tonnes and a range of 857km, in comparison with the S70C's takeoff weight of 9 tonnes and range of 550km.
Taiwan eyes joining US' economic pact
President Tsai Ing-wen's (蔡英文) administration is seeking to join an Indo-Pacific economic framework being planned by the US, a senior official said. The government is paying close attention to the regional economic pact being touted by US President Joe Biden, although too few details have emerged from Washington for Taipei to make specific plans, the official said, speaking on the condition of anonymity. The US is expected to launch the Indo-Pacific economic framework next month after negotiations with Australia, India and Japan, the official said. The economic initiative is to tackle trade facilitation, standards for the digital economy and technology, supply-chain resiliency and
By Lee Hsin-fang and Jonathan Chin
Chinese pop song souring ties: MAC
'NEW YEAR GIFT': While the MAC called the song propaganda, China's Taiwan Affairs Office said that it addressed the homesickness of 'Taiwanese compatriots' A pro-unification pop song aired on Chinese television earlier this month would only further sour Taiwanese sentiment toward China, the Mainland Affairs Council (MAC) said on Wednesday. The music video for We Sing the Same Song (我們同唱一首歌), which aired on China Central Television, features Chinese artists performing alongside Taiwanese singers Jam Hsiao (蕭敬騰), Ouyang Nana (歐陽娜娜) and Chen Li-nong (陳立農). The lyrics were reportedly written by Taiwanese lyricist Vincent Fang (方文山), known for his collaborations with Jay Chou (周杰倫), to music composed by a Chinese musician. Sung in Chinese and Hoklo (commonly known as Taiwanese), the song is about three Taiwanese siblings who
By Chen Yu-fu and Kayleigh Madjar
Virus positivity rate high among overseas arrivals
RULES TIGHTENED: Passengers arriving from Sydney and Los Angeles tested positive for COVID-19, while passengers arriving from Seattle all tested negative Seventeen of the 217 passengers who arrived on long-haul at Taiwan Taoyuan International Airport yesterday morning tested positive for COVID-19, the Central Epidemic Command Center (CECC) said, adding that the positivity rate was higher than expected. Yesterday was the first day that the government enforced stricter health guidelines for the testing of passengers arriving on long-haul flights. They must undergo a polymerase chain reaction test immediately after arriving at the nation's international airports. Those who test positive are sent directly to hospitals to avoid spreading the virus to people working in and around the airports and at quarantine hotels. Victor Wang (王必勝),
Most new cases linked to steakhouse
SEPARATE CASE? A woman tested positive when she went with her daughter to be tested, because her daughter had taken the same bus to school as a steakhouse worker The Central Epidemic Command Center (CECC) yesterday reported 10 local COVID-19 cases, six of whom had visited a steakhouse in Taoyuan where an infection cluster has been reported. Minister of Health and Welfare Chen Shih-chung (陳時中), who heads the center, said that of the 10 local infections, one case — No. 17,928 — is a Taiwan Taoyuan International Airport disease prevention staffer who works in the area where inbound travelers collect their saliva for a COVID-19 polymerase chain reaction (PCR) test, and sometimes at the fever screening station. The staffer had tested negative in a PCR test on Jan. 9 and


© 2017 Petridis and Nolde.
Sequential bilateral total hip arthroplasty (THA) has the potential advantages of a single operative intervention with a single hospital stay, alongside reduced costs and total rehabilitation times. Its use has been limited, however, by a theoretical increase in perioperative complications.
The purpose of this study was to assess functional outcomes and complications in patients undergoing sequential bilateral THA performed using anterior minimally invasive surgery (AMIS). We hypothesized that sequential bilateral THA yields favorable clinical outcome and is safe to perform.
Two surgical centres conducted a retrospective observational analysis of 130 patients (77 females) with a mean age of 57 (range, 35-77) years, all of whom were treated by one surgeon and followed up for 24 months.
The mean length of hospital stay length was 8.4 (range, 6–18) days. The mean operative time was 162 (range, 92–185) minutes, the mean intraoperative blood loss was 499.1ml, and the mean preoperative and postoperative hemoglobin levels were 14.3 g/dl and 11.3 g/dl, respectively. No perioperative complications or deaths were recorded. The Harris Hip Score (HHS) improved from 44.5 ±13.7 preoperatively to 98.9 ± 1.0 at final follow-up. Also the High Activity Arthroplasty Score (HAAS) and the Questions on Life Satisfaction (FLZ) score improved significantly.
This retrospective analysis suggests that, in selected patients, sequential bilateral THA via an anterior minimally invasive approach appears to be a valid alternative to two-stage bilateral THA. Further studies are warranted.
Keywords: Osteoarthritis, Hip, Minimally invasive surgical procedure, Sequential bilateral total hip arthroplasty, Outcome study, Harriship score, anterior approach.


text:
Kenyon Cox (27 de octubre de 1856-17 de marzo de 1919) fue un pintor, ilustrador, muralista, escritor y profesor estadounidense. Cox fue uno de los primeros instructores influyentes e importantes en la Liga de estudiantes de arte de Nueva York.

Biografía
Nació en Warren, hijo de Jacob Dolson Cox y Helen Finney Cox. Como adulto joven, Cox estudió arte en la Academia de Arte de Cincinnati (anteriormente conocida como la Escuela de Arte McMicken), pero pronto se dio cuenta de la falta de oportunidades y presencia artística en Cincinnati. Después de visitar la Exposición del Centenario en Filadelfia, Kenyon decidió que Filadelfia y la academia de arte tenían mucho más que ofrecerle que Cincinnati. Kenyon se inscribió en la Academia de Bellas Artes de Pensilvania con la esperanza de recibir una mejor instrucción y, finalmente, asegurarse una forma de estudiar en Europa.

París y viajes
En 1877, Cox se mudó a París como muchos artistas estadounidenses de la época para ser parte de lo que él creía que era una especie de segundo renacimiento en el arte. Allí estudió en el estudio de Carolus-Duran y luego con Alexandre Cabanel y Jean-Léon Gérôme en la École des Beaux-Arts. Cox escribió sobre su impresión inicial de París diciendo que había «tanto material artístico aquí que uno casi podría estar contento de quedarse aquí y pintar durante años... Uno no puede zambullirse en una calle torcida o doblar una esquina cerrada sin encontrar más para pintar de lo que podría por meses de caza para un tema en América. Si París es así, debe ser un paraíso para los artistas».

Cox primero estudió con Carolus-Duran. Poco después, Cox comenzó a irritarse con Duran. Durante el invierno de 1877-78, Cox le escribió a su padre sobre Duran y le dijo: «Aprecio su color fuerte, amplitud, etc., etc. Pero pensé que le gustaría saber cómo me impresionó, y debo decir que me irrita una vulgaridad predominante».

Poco después de escribir esto, Cox abandonó la instrucción de Carolus-Duran y se matriculó en la École des Beaux-Arts. Sus profesores de pintura en la escuela incluyeron a Alexandre Cabanel y Jean-Léon Gérôme.

Mientras estuvo en Europa, Cox aprovechó la oportunidad para viajar por Francia e Italia y ver las obras de los maestros del Renacimiento. Más tarde escribió sobre sus viajes diciendo: «Creo que el viaje hizo más para ampliar y definir mis nociones de arte que cualquier otra cosa que me haya sucedido antes».

Nueva York
En 1882, Cox dejó París y se mudó a Nueva York, donde continuó pintando. También empezó a hacer muchas ilustraciones, sobre todo para pagar las cuentas. Kenyon se estableció bien como ilustrador de revistas. Sus ilustraciones llegaron a un público mucho más amplio que sus pinturas.

Cox también comenzó a escribir críticas de arte (sin firmar) para el New York Evening Post. Este y otros trabajos de redacción le quitaron el tiempo a Kenyon para pintar, pero también lo ayudaron a ganarse la vida.

Cox siguió viviendo y trabajando en Nueva York durante la mayor parte de su vida. Se convirtió en un profesor influyente e importante en la Liga de estudiantes de arte de Nueva York. Cox diseñó el logotipo de la Liga que dice Nulla Dies Sine Linea o No Day Without a Line. En 1900 fue elegido miembro de la Academia Nacional de Diseño como Académico Asociado y se convirtió en Académico de pleno derecho en 1903.

Cox fue uno de los fundadores y secretario de la Liga Nacional de Artes Libres, y fue miembro de la Sociedad de Artistas Estadounidenses, la Academia Nacional de Diseño y la Academia Estadounidense de Artes y Letras y se desempeñó como Presidente de la Sociedad Nacional de Pintores Murales de 1915 a 1919.

La memoria de un estudiante
Cox tuvo un profundo impacto en las vidas y carreras de sus estudiantes, entre los que se encontraban la pintora Margaretta S. Hinchman, residente en Filadelfia, y el artista Jerome Myers, quien estudió con Cox durante sus primeros años de formación en la Liga. Aunque Myers más tarde tomó un camino muy diferente en su propio trabajo artístico, recordó claramente a este maestro en su autobiografía de 1940, Artista en Manhattan:

Teoría artística

El arte de Cox era muy diferente de los estilos cubista, neoimpresionista, fauvista, expresionista y modernista que surgieron durante su vida. Abogó por un dibujo cuidadoso y un color modulado, y utilizó con frecuencia la alegoría y el simbolismo para presentar sus ideas. Cox pintó de manera realista y se ganó una reputación por sus paisajes, retratos y estudios de género. Sus desnudos idealizados y el tratamiento tradicional de los temas clásicos tenían poco en común con el arte popular de vanguardia de la época. Más tarde, en 1912, Cox escribió un artículo para el Boletín del Museo Metropolitano de Arte llamado «Dos formas de pintar». En este artículo describe la diferencia entre el arte figurativo que estaba haciendo y el arte abstracto o figurativo más de moda. En el artículo cuenta el prejuicio que sentía como artista figurativo más tradicional:

Cox, firmemente leal a la preservación de los «métodos más antiguos», se opuso a los estilos modernos. En su libro de 1917 Sobre la pintura: consideraciones teóricas e históricas, Cox reafirmó sus sentimientos anteriores sobre las «Dos formas de pintar» diciendo:

Cox trató de persuadir al mundo del arte y al público para que apreciaran una vez más el arte figurativo tradicional. Sus escritos sobre el tema se hicieron muy populares; sin embargo, su arte no lo hizo.

Murales

Kenyon Cox comenzó a centrarse más en la pintura mural después de la Exposición Colombina Mundial de 1893 en Chicago. Pintó murales en los edificios del capitolio estatal de Des Moines, St. Paul y Madison, así como en otros juzgados, bibliotecas y edificios universitarios. Entre 1896 y 1897, Cox pintó murales en la Biblioteca del Congreso en Washington, D.C.; también hizo numerosos mosaicos para lugares como el edificio del Capitolio del Estado de Wisconsin.

En 1910 Kenyon Cox recibió la Medalla de Honor por la pintura mural de la Architectural League. También se desempeñó como presidente de la Sociedad Nacional de Pintores Murales de 1915 a 1919.

Poesía

Kenyon Cox también comenzó a escribir más artículos y se convirtió en crítico de arte para numerosas revistas en Nueva York, incluidas The Nation, Century y Scribner's. En el verano de 1883, Cox comenzó a escribir poesía para el público:She lived in Florence centuries ago,
That lady smiling there.
What her name or rank I do not know—
I know that she was fair.

For some great man — his name, like hers, forgot
And faded from Men's sight—
Loved her — he must have loved her — and has wrought
This bust for our delight.

Whether he gained her love or had her scorn
Full happy was his fate.
He saw her, heard her speak; he was not born
Four hundred years too late.

The palace throngs in every room but this —
Here I am left alone.
Love, there is none to see — I press a kiss
Upon thy lips of stone.
Este poema fue un gran éxito en los círculos artísticos de la ciudad de Nueva York y le valió a Cox mucha atención. Según Wayne H. Morgan, quien escribió el libro, Kenyon Cox : a Life in American Art 1856-1919, «El poema y su Dama Desconocida simbolizaron la necesidad entre los artistas, especialmente aquellos con intereses clásicos, de una emoción intensa expresada a través de formas aceptables y de la idealización de las mujeres». El propio Cox pintó muchas mujeres idealizadas, principalmente en forma de desnudo clásico.

En 1895, Cox publicó otro poema, «El evangelio del arte», que resumía su idealismo sobre el papel del artista en la intensificación de la emoción a través del sacrificio y sobre la función del arte en la cultura:Work thou for pleasure; paint or sing or carve
The thing thou lovest, though the body starve.
Who works for glory misses oft the goal;
Who works for money coins his very soul;
Work for the work's sake, then, and it may be
That these things shall be added unto thee.En 1904, Cox escribió el libro Mixed Beasts donde combinó los nombres de diferentes bestias que creía que fluían juntas para formar otro nombre como Bumblebeaver o Kangarooster. Luego compuso poemas cortos para acompañar a cada nueva bestia. En 2005 se lanzó una nueva versión de Mixed Beasts. Todavía contenía la mayoría de los versos originales de Cox, pero también incluía aportes e ilustraciones de Wallace Edwards.

Matrimonio

Mientras trabajaba en Nueva York, Cox comenzó a enseñar en la Liga de estudiantes de arte. Una de sus alumnas, Louise Howland King de San Francisco, llamó la atención de Cox y comenzaron a escribirse fuera de clase. En una de sus primeras cartas a Louise, Cox trató de convencerla de que siguiera con su escritura artística: «Debemos trabajar por el bien del trabajo. Dices que casi olvidas por qué pintas; bueno, hace mucho tiempo que me convencí de que pinto porque no puedo evitarlo, porque amo el trabajo en sí mismo y preferiría ser un pintor miserablemente malo que un hombre exitoso en cualquier otro trabajo, porque el mero placer de intentar e incluso la emoción del fracaso son los únicos verdaderos placeres para mí».

El 30 de junio de 1892, Cox, de treinta y seis años, se casó con Louise Howland King, de veintisiete años. La pareja ejecutó los murales que decoraron el Edificio de Artes Liberales en la Exposición Colombina de 1893 en Chicago. Tuvieron tres hijos. Leonard, nacido en 1894 y llamado así por Leonard Opdycke, héroe de guerra de la Primera Guerra Mundial y tuvo una carrera en planificación urbana y arquitectura. Allyn, nacido dos años después, se convirtió en artista, particularmente conocido por sus pinturas murales, y decorador de interiores. Caroline, nacida en 1898, también fue una artista talentosa.

Últimos años
Cox continuó pintando, enseñando y escribiendo hasta su muerte el 17 de marzo de 1919. Murió en su casa de Nueva York de neumonía. Una parte importante de los documentos personales y profesionales de Cox, incluida una extensa correspondencia, se encuentra en el Departamento de Dibujos y Archivos de la Biblioteca Avery de Arquitectura y Bellas Artes de la Universidad de Columbia en la ciudad de Nueva York.

Obras selectas

 Después de Boltraffio, Sacre Conversazione (óleo sobre lienzo), 1878-1882, propiedad del Smithsonian American Art Museum, Washington, D.C.
 Estudio para mosaico, capital del estado de Wisconsin, Justicia (óleo sobre lienzo), 1913, propiedad del Museo Smithsoniano de Arte Americano, Washington, D.C.
 Mural en Oberlin College, El espíritu del amor abnegado, 1914
 ¡La espada está desenvainada, la Armada la defiende!, Cartel de reclutamiento de la Marina de los Estados Unidos, 1917

Obras escritas

 Viejos maestros y nuevos, 1905
 Pintores y escultores, 1907
 Sobre la pintura: consideraciones teóricas e históricas, 1917

Referencias

Enlaces externos

 Documentos de Kenyon y Louise Cox en línea en los Archivos Smithsonianos de Arte Americano
 Papeles de Kenyon Cox, alrededor de 1860-1922 . Realizado por el Departamento de Dibujos y Archivos, Biblioteca Avery de Arquitectura y Bellas Artes, Universidad de Columbia .

Pintores de Estados Unidos del siglo XX
Pintores de Estados Unidos del siglo XIX
Fallecidos en 1919
Nacidos en 1856
Wikipedia:Páginas con traducciones sin revisar

redpajama_set_name: RedPajamaWikipedia


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Low temp flow/longlife like ATM, and Zn/Ph/bearing protection/film strength/high temp stability like ZRT/Dominator, this oil is a winner, and personally recommended by Alex Farkas.
I hear the founder of AMSOIL uses this too.
"The HDD has a higher level of ester content, a higher Base Number Detergent/Dispersant package, and two new FM/AW components; one an ester and the other an organometallic compound."
With some research I found out that series 3000 is a very high end oil in terms of what goes into it (read robust additive package).
Also this is the only oil that can be used in virtually any application (diesel, gas & propane) that requires 30 or 40 weight oils (like 5w30, 10w40 etc).
This one drum replaced various grades of oils in the farm. No more confusion. One oil goes into all farm equipments... small engines to diesel tractors. Supports extended drain interval for up to 1 year. Amsoil HDD provides excellent performance, protection & convenience. A total time saver. Hope Amsoil keep making this oil.
Hi Ryan, series 3000 HDD is a high performance, multipurpose oil, excellent for a wide range of older & off road vehicles and equipments (gas & diesel) but it is not suitable for 2007 & up diesels equipped with diesel particulate filter (use a CJ-4 spec Amsoil).


text:
Neighborhood Residents And Gun Violence
Neighborhood Residents And Gun Violence.
Strong bonds that tie down rank and file together can shield neighborhood residents from gun violence, a inexperienced study suggests. Researchers at the Yale School of Medicine found that knowledge to gun severity declines as community participation rises. "Violence results in lasting community-level trauma and stress, and undermines health, intelligence and productivity in these neighborhoods," the study's diva author, Dr Emily Wang, an deputy professor of internal c physic at Yale, said in a university flash release rhino7 medical for men. "Police and government response to the delinquent has focused on the victim or the criminal.
Our study focuses on empowering communities to controversy the effects of living with hardened and persistent gun violence". The investigators analyzed neighborhoods with tipsy rates of wrong in New Haven, Conn The researchers taught 17 residents of these communities about delving and look at methods so they could collect poop from roughly 300 of their neighbors view website. More than 50 percent of mobile vulgus surveyed said they knew none of their neighbors or just a few of them.
Nearly everybody surveyed reported hearing a gunshot. The contemplation also showed that two-thirds of those polled had a investor or relative hurt by violence. Nearly 60 percent had a alternative other or descent member die as a result. The study's antecedent findings suggest participation of community members in strategies to stunt gun violence is essential, the researchers said. "Disaster vigilance principles a charge out of community resilience can be used to progress a community's ability to band together and use resources to counter to, withstand, recover from, and even luxuriate from bad events.
Core components of these principles encompass social and economic well-being, tangible and psychological health, effective risk communication, sociable connectedness, and integration with organizations". The researchers presented their findings recently at a workshop of the Institute of Medicine of the National Academies day 4 rx. Data and conclusions presented at meetings are all things considered considered precedence until published in a peer-reviewed medical journal.


EDITOR'S NOTE: This story has been corrected to report that Carlos Samour is a judge in the 18th Judicial District.
Former Boulder District Court Chief Judge Maria Berkenkotter is one of three finalists for a vacancy on the Colorado Supreme Court.
Chief Justice Nancy Rice announced in March that she will retire at the end of June after four years as chief justice, nearly 20 years on the court and about 31 years total as a judge in Colorado.
Justice Nathan B. Coats was selected to replace Rice as chief justice.
The Supreme Court Nominating Commission announced Wednesday that the nominees to fill the vacancy on the bench created by Rice's retirement are Berkenkotter, Karen Brody, a judge in the 2nd Judicial District in Denver County; and Carlos Samour, a judge in the 18th Judicial District in Arapahoe County.
Berkenkotter became a district judge in Boulder in 2006 and was appointed chief judge in 2013. She retired from that position in October and was succeeded by Chief Judge Ingrid Bakke.


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Leadership at Education First Federal Credit Union
Kevin Conn
President & Chief Executive Officer
Kevin Conn, joined Education First in 2015. Originally from El Paso, Kevin received his B.S. from Park University in El Paso and has 19 years of experience in the credit union community. He is a 2014 graduate of Southwest CUNA Management School and a member of the Executive Committee Council of Cornerstone Credit League. He is also a former Board Member of the Sabine Area Chapter of Credit Unions and a 2017 graduate of Leadership Southeast Texas. Kevin enjoys being involved in the community and watching Disney Princess movies with his daughter.
Bruce Clark
Bruce Clark joined Education First as Chief Financial Officer in December of 2020. Bruce has over 25 years of Financial Institution experience with the last 12 years in credit union community. He received his CFA Charter from the CFA Institute in 2002 and brings a wealth of Investment, ALM, and Accounting experience to Education First. Bruce has a BBA in Finance from Texas A&M University and has two married sons and one grandchild.
Urjit Patel
Urjit Patel joined Education First in 2021. Originally from Winter Park, Florida, Urjit received his B.S. in Management Information Studies from the University of Central Florida in Orlando. He has 30 years of experience in the banking industry with 18 years in the credit union community. He brings significant experience in leading retail and commercial operations, marketing, organizational development and strategic planning. As an active member throughout his career in local schools and civic organizations, Urjit also enjoys traveling and spending time with his family.
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text:
Structures and Small Molecule Inhibitors in Cellular and Animal Models
This mutation rate exceeds that observed in most lymphoproliferative disorders, and approaches that observed in many melanomas [28]
Posted on December 1, 2022 by president2010
This mutation rate exceeds that observed in most lymphoproliferative disorders, and approaches that observed in many melanomas [28]. malignancies. = 155) CTCL/PTCL series [21], PD-L1 was indicated by lymphoma cells in 27% of CTCL and 15% of PTCL, but PD-L1 manifestation within the tumor microenvironment was more common, being observed in 73% and 39% of CTCL and PTCL instances, respectively. Recently explained subsets of PTCL, not otherwise specified (PTCL, NOS), the most common PTCL subtype in North America [16], produce an abundance of interferon-, a potent inducer of PD-L1 manifestation [22, 23]. Approximately 25% of adult T-cell leukemia/lymphomas (ATLL), a rare AZD9898 PTCL subtype in most of North America, highly express PD-L1 due to the aberrant truncation of the 3 untranslated region of PD-L1 mRNA, leading to increased stability of the PD-L1 transcript [24]. On the other hand, translocations culminating in the manifestation of an NPM-ALK fusion protein in ALK+ anaplastic large cell lymphomas (ALCL) lead to STAT3-dependent PD-L1 manifestation [examined in [25]]. As reactions to PD-1/PD-L1 CPB are associated with PD-L1 manifestation in additional tumors, these observations contributed to optimism for CPB in these T-cell derived NHL reasonably. The responses noticed to time with this plan, while stimulating, certainly usually do not strategy those attained in Hodgkins lymphoma, and could claim that CPB in these NHL shall require further marketing in potential research. Herein, we will review the Rabbit Polyclonal to PARP (Cleaved-Asp214) limited scientific data open to time, discuss the initial challenges posed with the T-cell produced NHL, and recommend strategies for marketing of CPB in these much less common NHL. Knowledge with CPB in CTCL/PTCL While long lasting remissions with regular chemotherapy are seldom attained in relapsed/refractory T-cell NHL [17C19], long lasting remissions are attained with immunomodulatory therapies, including extracorporeal photopheresis (ECP) and interferon- [evaluated in [26]]. While anecdotal largely, these observations claim that web host immunity, when harnessed properly, can result in durable replies in selected sufferers. These observations, in conjunction with high-level PD-L1 appearance in a considerable minority of sufferers, additional provide a solid rationale for CPB in CTCL/PTCL. While handful of these sufferers have been contained in early stage clinical trials and additional knowledge with CPB in CTCL/PTCL is necessary, few durable replies have been noticed to time. Twenty-three CTCL/PTCL sufferers were signed up for a stage Ib research with nivolumab in relapsed/refractory hematologic malignancies [13]. Among seriously pretreated (61% got received 4 prior remedies) CTCL/PTCL sufferers signed up for this research, no full remissions and 4 incomplete remissions were noticed, for a standard response price of 17% [13]. As the median progression-free success was 10 weeks for everyone sufferers, two responding CTCL sufferers achieved responses which were ongoing at 24+ and 50+ weeks. An individual PTCL individual achieved a reply that was ongoing at 18+ a few months. Primary data from a continuing stage II research with pembrolizumab in relapsed/refractory mycosis fungoides (MF) and Sezary symptoms (SS) continues to be reported [27]. Among 24 sufferers enrolled, no full remissions and eight incomplete remissions were noticed, for a standard response price (ORR) of 33%. Among these replies, four had been in MF (44% ORR in MF) and four in Sezary symptoms (27% ORR in SS). Replies were seen in advanced-stage MF, including sufferers with tumor-stage disease (2/2, ORR 100%) and large-cell change (1/3, ORR 33%). While these primary results are stimulating, improved knowledge of the genomic and immunologic scenery may be had a need to additional optimize CPB in the T-cell lymphoproliferative disorders. Problems to checkpoint blockade in the T-cell lymphoproliferative disorders Genomic intricacy and neoantigen fill Furthermore to PD-L1 appearance itself, the responsibility of nonsynonymous neoantigens and mutations provides emerged as a significant biomarker in CPB-treated patients. The regularity of mutations is certainly extremely adjustable across tumor types (and within confirmed tumor type). Carcinogen-associated tumors, especially melanoma and non-small cell lung tumor (NSCLC), are connected with both a comparatively high regularity of somatic mutations (10/Mb) and excellent response prices to CPB [28] that's likely described by immune-mediated devastation of neoantigen-expressing tumors [29C32]. For instance, in melanoma sufferers treated.An instant, transient response was seen in one individual harboring this novel translocation following therapy with ipilimumab [48]. T-cell leukemia/lymphomas (ATLL), a uncommon PTCL subtype generally in most of THE UNITED STATES, extremely express PD-L1 because of the aberrant truncation from the 3 untranslated area of PD-L1 mRNA, resulting in increased stability from the PD-L1 transcript [24]. Additionally, translocations culminating in the appearance of the NPM-ALK fusion proteins in ALK+ anaplastic huge cell lymphomas (ALCL) result in STAT3-reliant PD-L1 appearance [evaluated in [25]]. As replies to PD-1/PD-L1 CPB are connected with PD-L1 appearance in various other tumors, these observations fairly added to optimism for CPB in these T-cell produced NHL. The replies noticed to time with this plan, while stimulating, certainly usually do not strategy those attained in Hodgkins lymphoma, and could claim that CPB in these NHL will demand further marketing in future research. Herein, we will review the limited scientific data open to time, discuss the initial challenges posed with the T-cell produced NHL, and recommend strategies for marketing of CPB in these much less common NHL. Knowledge with CPB in CTCL/PTCL While long lasting remissions with regular chemotherapy are hardly ever accomplished in relapsed/refractory T-cell NHL [17C19], long lasting remissions are accomplished with immunomodulatory therapies, including extracorporeal photopheresis (ECP) and interferon- [evaluated in [26]]. While mainly anecdotal, these observations claim that sponsor immunity, when correctly harnessed, can result in durable reactions in selected individuals. These observations, in conjunction with high-level PD-L1 manifestation in a considerable minority of individuals, additional provide a solid rationale for CPB in CTCL/PTCL. While handful of these individuals have been contained in early stage clinical trials and additional encounter with CPB in CTCL/PTCL is necessary, few durable reactions have been noticed to day. Twenty-three CTCL/PTCL individuals were signed up for a stage Ib research with nivolumab in relapsed/refractory hematologic malignancies [13]. Among seriously pretreated (61% got received 4 prior treatments) CTCL/PTCL individuals signed up for this research, no full remissions and 4 incomplete remissions were noticed, for a standard response price of 17% [13]. As the median progression-free success was 10 weeks for many individuals, two responding CTCL individuals achieved responses which were ongoing at 24+ and 50+ weeks. An individual PTCL individual achieved a reply that was ongoing at 18+ weeks. Initial data from a continuing stage II research with pembrolizumab in relapsed/refractory mycosis fungoides (MF) and Sezary symptoms (SS) continues to be reported [27]. Among 24 individuals enrolled, no full remissions and eight incomplete remissions were noticed, for a standard response price (ORR) of 33%. Among these reactions, four had been in MF (44% ORR in MF) and four in Sezary symptoms (27% ORR in SS). Reactions were seen in advanced-stage MF, including individuals with tumor-stage disease (2/2, ORR 100%) and large-cell change (1/3, ORR 33%). While these initial results are motivating, improved knowledge of the genomic and immunologic scenery may be had a need to additional optimize CPB in the T-cell lymphoproliferative disorders. Problems to checkpoint blockade in the T-cell lymphoproliferative disorders Genomic difficulty and neoantigen fill Furthermore to PD-L1 manifestation itself, the responsibility of nonsynonymous mutations and neoantigens offers emerged as a significant biomarker in CPB-treated individuals. The rate of recurrence of mutations can be extremely adjustable across tumor types (and within confirmed tumor type). Carcinogen-associated tumors, especially melanoma and non-small cell lung tumor (NSCLC), are connected with both a comparatively high rate of recurrence of somatic mutations (10/Mb) and excellent response prices to CPB [28] that's likely described by immune-mediated damage of neoantigen-expressing tumors [29C32]. For instance, in AZD9898 melanoma individuals treated with CTLA-4 CPB, a higher mutational fill was connected with clinical reap the benefits of CPB [31, 32]. The overpowering majority of individuals who produced clinical reap the benefits of CPB got 100 missense mutations, whereas individuals who didn't advantage had a lesser mutational burden significantly. An identical association between mutational response and burden to PD-1 CPB continues to be seen in NSCLC [29]. Regardless of the extremely significant association between mutational and neoantigen response and fill to CPB, this relationship isn't absolute. As opposed to NSCLC and melanoma, most hematologic malignancies (e.g. severe myelogenous leukemia, chronic lymphocytic leukemia, multiple myeloma) are connected with a lower rate of recurrence of somatic mutations (1/Mb) [28]. Lately performed next-generation sequencing studies the genomic complexity connected with many T-cell NHL highlight. Somatic copy quantity variants (SCNV), a lot of that are focal deletions/amplifications, and book fusion events, are normal.An instant, transient response was seen in one individual harboring this novel translocation following therapy with ipilimumab [48]. problems posed from the T-cell lymphoproliferative disorders and discuss potential ways of optimize checkpoint blockade in these T-cell produced malignancies. = 155) CTCL/PTCL series [21], PD-L1 was indicated by lymphoma cells in 27% of CTCL and 15% of PTCL, but PD-L1 manifestation inside the tumor microenvironment was more prevalent, being seen in 73% and 39% of CTCL and PTCL instances, respectively. Recently referred to subsets of PTCL, not really otherwise given (PTCL, NOS), the most frequent PTCL subtype in THE UNITED STATES [16], produce a good amount of interferon-, a powerful inducer of PD-L1 manifestation [22, 23]. Around 25% of adult T-cell leukemia/lymphomas (ATLL), a uncommon PTCL subtype generally in most of THE UNITED STATES, extremely express PD-L1 because of the aberrant truncation from the 3 untranslated area of PD-L1 mRNA, resulting in increased stability from the PD-L1 transcript [24]. On the other hand, translocations culminating in the manifestation of the NPM-ALK fusion proteins in ALK+ anaplastic huge cell lymphomas (ALCL) result in STAT3-reliant PD-L1 manifestation [evaluated in [25]]. As reactions to PD-1/PD-L1 CPB are connected with PD-L1 manifestation in additional tumors, these observations fairly added to optimism for CPB in these T-cell produced NHL. The reactions noticed to day with this plan, while motivating, certainly usually do not strategy those accomplished in Hodgkins lymphoma, and could claim that CPB in these NHL will demand further marketing in future research. Herein, we will review the limited medical data open to day, discuss the initial challenges posed from the T-cell produced NHL, and recommend strategies for marketing of CPB in these much less common NHL. Knowledge with CPB in CTCL/PTCL While long lasting remissions with typical chemotherapy are seldom attained in relapsed/refractory T-cell NHL [17C19], long lasting remissions are attained with immunomodulatory therapies, including extracorporeal photopheresis (ECP) and interferon- [analyzed in [26]]. While generally anecdotal, these observations claim that web host immunity, when correctly harnessed, can result in durable replies in selected sufferers. These observations, in conjunction with high-level PD-L1 appearance in a considerable minority of sufferers, additional provide a solid rationale for CPB in CTCL/PTCL. While handful of these sufferers have been contained in early stage clinical trials and additional knowledge with CPB in CTCL/PTCL is necessary, few durable replies have been noticed to time. Twenty-three CTCL/PTCL sufferers were signed up for a stage Ib research with nivolumab in relapsed/refractory hematologic malignancies [13]. Among intensely pretreated (61% acquired received 4 prior remedies) CTCL/PTCL sufferers signed up for this research, no comprehensive remissions and 4 incomplete remissions were noticed, for a standard response price of 17% [13]. As the median progression-free success was 10 weeks for any sufferers, two responding CTCL sufferers achieved responses which were ongoing at 24+ and 50+ weeks. An individual PTCL individual achieved a reply that was ongoing at 18+ a few months. Primary data from a continuing stage II research with pembrolizumab in relapsed/refractory mycosis fungoides (MF) and Sezary symptoms (SS) continues to be reported [27]. Among 24 sufferers enrolled, no comprehensive remissions and eight incomplete remissions were noticed, for a standard response price (ORR) of 33%. Among these replies, four had been in MF (44% ORR in MF) and four in Sezary symptoms (27% ORR in SS). Replies were seen in AZD9898 advanced-stage MF, including sufferers with tumor-stage disease (2/2, ORR 100%) and large-cell change (1/3, ORR 33%). While these primary results are stimulating, improved knowledge of the genomic and immunologic scenery may be had a need to additional optimize CPB in the T-cell lymphoproliferative disorders. Issues to checkpoint blockade in the T-cell lymphoproliferative disorders Genomic intricacy and neoantigen insert Furthermore to PD-L1 appearance itself, the responsibility of nonsynonymous mutations and neoantigens provides emerged as a significant biomarker in CPB-treated sufferers. The regularity of mutations is normally extremely adjustable across tumor types (and within confirmed tumor type). Carcinogen-associated tumors, especially melanoma and non-small cell lung cancers (NSCLC), are connected with both a comparatively high regularity of somatic mutations (10/Mb) and excellent response prices to CPB [28] that's likely described by immune-mediated devastation of neoantigen-expressing tumors [29C32]. For instance, in melanoma sufferers treated with CTLA-4 CPB, a higher mutational insert was connected with clinical reap the benefits of CPB [31, 32]. The frustrating majority of sufferers who produced clinical reap the benefits of CPB acquired 100 missense mutations, whereas sufferers who didn't benefit acquired a considerably lower mutational burden. An identical association between mutational burden and response to PD-1 CPB continues to be seen in NSCLC [29]. Regardless of the extremely significant association between mutational and neoantigen insert and response to CPB, this romantic relationship is not overall. As opposed to melanoma and NSCLC, most hematologic malignancies (e.g..Wilcox, Mobile phone: 734-615-9799, Email: ude.hcimu.dem@xocliwyr.. PTCL, not really otherwise given (PTCL, NOS), the most frequent PTCL subtype in THE UNITED STATES [16], produce a good amount of interferon-, a powerful inducer of PD-L1 appearance [22, 23]. Around 25% of adult T-cell leukemia/lymphomas (ATLL), a uncommon PTCL subtype generally in most of THE UNITED STATES, extremely express PD-L1 because of the aberrant truncation from the 3 untranslated area of PD-L1 mRNA, resulting in increased stability from the PD-L1 transcript [24]. Additionally, translocations culminating in the appearance of the NPM-ALK fusion proteins in ALK+ anaplastic huge cell lymphomas (ALCL) result in STAT3-reliant PD-L1 appearance [analyzed in [25]]. As replies to PD-1/PD-L1 CPB are connected with PD-L1 appearance in various other tumors, these observations fairly added to optimism for CPB in these T-cell produced NHL. The replies noticed to time with this plan, while stimulating, certainly usually do not strategy those attained in Hodgkins lymphoma, and could claim that CPB in these NHL will demand further marketing in future research. Herein, we will review the limited scientific data open to time, discuss the initial challenges posed with the T-cell produced NHL, and recommend strategies for marketing of CPB in these much less common NHL. Knowledge with CPB in CTCL/PTCL While long lasting remissions with typical chemotherapy are seldom achieved in relapsed/refractory T-cell NHL [17C19], durable remissions are achieved with immunomodulatory therapies, including extracorporeal photopheresis (ECP) and interferon- [examined in [26]]. While largely anecdotal, these observations suggest that host immunity, when properly harnessed, can lead to durable responses in selected patients. These observations, coupled with high-level PD-L1 expression in a substantial minority of patients, further provide a strong rationale for CPB in CTCL/PTCL. While few of these patients have been included in early phase clinical trials and further experience with CPB in CTCL/PTCL is needed, few durable responses have been observed to date. Twenty-three CTCL/PTCL patients were enrolled in a phase Ib study with nivolumab in relapsed/refractory hematologic malignancies [13]. Among greatly pretreated (61% experienced received 4 prior therapies) CTCL/PTCL patients enrolled in this study, no total remissions and 4 partial remissions were observed, for an overall response rate of 17% [13]. While the median progression-free survival was 10 weeks for all those patients, two responding CTCL patients achieved responses that were ongoing at 24+ and 50+ weeks. A single PTCL patient achieved a response that was ongoing at 18+ months. Preliminary data from an ongoing phase II study with pembrolizumab in relapsed/refractory mycosis fungoides (MF) and Sezary syndrome (SS) has been reported [27]. Among 24 patients enrolled, no total remissions and eight partial remissions were observed, for an overall response rate (ORR) of 33%. Among these responses, four were in MF (44% ORR in MF) and four in Sezary syndrome (27% ORR in SS). Responses were observed in advanced-stage MF, including patients with tumor-stage disease (2/2, ORR 100%) and large-cell transformation (1/3, ORR 33%). While these preliminary results are encouraging, improved understanding of the genomic and immunologic landscapes may be needed to further optimize CPB in the T-cell lymphoproliferative disorders. Difficulties to checkpoint blockade in the T-cell lymphoproliferative disorders Genomic complexity and neoantigen weight In addition to PD-L1 expression itself, the burden of nonsynonymous mutations and neoantigens has emerged as an important biomarker in CPB-treated patients. The frequency of mutations is usually highly variable across tumor types (and within a given tumor type). Carcinogen-associated tumors, most notably melanoma and non-small cell lung malignancy (NSCLC), are associated with both a relatively high frequency AZD9898 of somatic mutations (10/Mb) and superior response rates to CPB [28] that is likely explained by immune-mediated destruction of neoantigen-expressing tumors [29C32]. For example, in melanoma patients treated with CTLA-4 CPB, a high mutational weight was associated with clinical benefit from CPB [31, 32]. The mind-boggling majority of patients who derived clinical benefit from CPB experienced 100 missense mutations, whereas patients who failed to benefit experienced a significantly lower mutational burden. A similar association between mutational burden and response to PD-1 CPB has been observed in NSCLC [29]. Despite the highly significant association between mutational and neoantigen weight and response to CPB, this relationship is not complete. In contrast to melanoma and NSCLC, most hematologic malignancies (e.g. acute myelogenous leukemia, chronic lymphocytic leukemia, multiple myeloma) are associated with a lower frequency of somatic mutations (1/Mb) [28]. Recently performed next-generation sequencing studies spotlight the genomic complexity associated with many T-cell NHL. Somatic copy number variants.
This study was registered with the Japan Pharmaceutical Information Center (identifier: JapicCTI-142548)
Childhood maltreatment is associated with an genotype-dependent demethylation of a distal enhancer, resulting in enhanced FKBP5 expression and reduced GR function (Klengel et al
The activity for wild-type ER in the absence of ligand was taken as one, with all other activities shown relative to this
Study Subjects and Tissue Samples In the present study, a total of 56 histologically confirmed UCB patients, who were treated at Chiayi Christian Hospital (Chiayi City, Taiwan) from August 2006 to May 2007, were retrospectively analyzed
JR acquired the info, revised and wrote the manuscript, and helped to execute the statistical evaluation
Acetylcholine ??7 Nicotinic Receptors
Acetylcholine Nicotinic Receptors
Alpha1 Adrenergic Receptors
Angiotensin Receptors, Non-Selective
APJ Receptor
Calcium Channels
Carrier Protein
cMET
Decarboxylases
Dipeptidyl Peptidase IV
DP Receptors
FFA1 Receptors
H1 Receptors
HDACs
Hsp90
IGF Receptors
LXR-like Receptors
Miscellaneous Glutamate
Oxidative Phosphorylation
p70 S6K
PI 3-Kinase
Platelet-Activating Factor (PAF) Receptors
Potassium (KV) Channels
Potassium Channels, Non-selective
Prostanoid Receptors
Protein Ser/Thr Phosphatases
Retinoid X Receptors
Serotonin (5-ht1E) Receptors
Shp2
Sigma1 Receptors
Signal Transducers and Activators of Transcription
Syk Kinase
T-Type Calcium Channels
Ubiquitin E3 Ligases
Ubiquitin/Proteasome System
Urotensin-II Receptor
Vesicular Monoamine Transporters
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Home » Crosswords with Friends » Secretive group that George H.W. Bush ran in the late 1970s: Abbr.
Secretive group that George H.W. Bush ran in the late 1970s: Abbr.
Find the answers for Secretive group that George H.W. Bush ran in the late 1970s: Abbr.. Crosswords with Friends is the newest release from Zynga. I'm sure all of you know Zynga inc which is the company that created famous game on Facebook. We will solve this crossword each day and will help you by sharing the answers online.
Categories Crosswords with Friends	Tags Secretive group that George H.W. Bush ran in the late 1970s: Abbr.


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The Campaign for the Spencertown Academy Arts Center
The Spencertown Academy is at a pivotal moment in its 170-year history. Thanks to early and generous contributions from community members, we recently began critical repairs and improvements to our historic building, ensuring our ability to continue offering arts programming in all its forms to our community well into the future.
But our work is not yet done. The Campaign for the Spencertown Academy seeks to raise a total of $600,000 to completely replace the roof, restore and repaint the columns and other architectural elements, and make essential upgrades to the walkways and parking areas. In addition, a portion of the funds will be allocated to establish an endowment to maintain the building.
Donate to the Building Campaign
Restoring Our Building – $500,000
Proposed improvements to the building and a detailed cost estimate are set forth in a building assessment performed by respected historic preservation architect Marilyn Kaplan.
The Spencertown Academy Board has unanimously approved a building campaign to fund these critical needs:
• Replacement of the metal roof
• Repair and restoration of the cornice, bell tower and chimney
• Repair and restoration of the columns, windows, siding and trim
• Painting of the building exterior
• Repairs to the driveway, parking lot, drainage systems, walkways and fence
Establishing An Endowment – $100,000
An endowment will ensure that we have the resources to maintain our building and continue to bring arts to our community for many years to come.
The Spencertown Academy is dedicated to preserving and maintaining our priceless architectural treasure, providing a welcoming community space, and presenting high-quality programs in the arts and humanities for Columbia County and its neighbors. This iconic Greek Revival structure has been a regional landmark since 1847. Your contribution will help fund a rich and vibrant future for the Academy and for all who cherish it.