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Agents address wound-healing cascade
Wound modulation research focuses on new targets and combination therapy
"Approaches to wound modulation after filtration surgery have not changed much over the past 20 years. However, early studies of new targeted interventions and combination approaches have provided some encouraging results," said Dr Malik Y. Kahook, during glaucoma subspeciality day at the annual meeting of the American Academy of Ophthalmology.
Results of an animal study reported by Sherwood1 provide evidence supporting the concept of using a sequential treatment regimen incorporating multiple novel agents targeting different mediators of wound healing. Also, a pilot clinical trial conducted by Dr Kahook yielded encouraging results about a combination regimen consisting of the anti-vascular endothelial growth factor (VEGF) agent, ranibizumab (Lucentis, Genentech) and MMC.2
The two study groups were similar in their preoperative mean IOP and mean bleb scores on the first day after surgery. However, at the end of the 6-month postoperative follow-up, there were statistically significant differences favouring the combination group in three of the grading system categories: peripheral bleb area, peripheral bleb vascularity and non-bleb-related peripheral conjunctiva vascularity. There were no cases of bleb leaks, all patients remained off medications and vision remained stable.
"Ranibizumab also has an antiinflammatory effect, and I was struck by the quiet nature of the eyes that had been treated with this anti-VEGF agent. Now, further studies are needed to validate these early findings and understand better the role of antiVEGF treatment at the time of trabeculectomy," said Dr Kahook, who added that a follow-up trial is under way that includes a third arm in which patients receive only ranibizumab at the conclusion of surgery.


Tier II and III markets are more attractive to investors focused on the Americas as they look to cities with strong fundamentals, according to a CBRE survey.
The three properties all are located in Ohio and consist of a SpringHill Suites by Marriott, a Holiday Inn and a Holiday Inn Express.
Waterford assumed management of eight hotels previously operated by Waterton, while Waterton will concentrate on real estate investment.
The United States has the largest travel and tourism economy, contributing nearly $1.6 trillion to gross domestic product in 2018.
Uncertainty quickly is becoming the industry's favorite word, but one expert believes the current strong state of the industry could persist.
Panelists at the first day of the International Hotel Investment Forum in Berlin discussed the latest trends in global money movement.


3. Minimum of 3 years experience Medical Staff Services Department and/or acute care hospital experience required.
4. Must have strong computer, communication, and writing skills.
5. Must be proficient in Microsoft Office: Word, Excel, and PowerPoint.
6. Must exhibit a positive attitude and willingness to learn.
7. Knowledge of medical terminology and medical staff services and/or acute care hospital experience, preferred.


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Category Archives: MI5
Manchester Terror Attack False Flag (Ariana Grande Concert Explosion)(distraction from #pizzagate), MI5
UK MI5 intelligence to investigate itself after Manchester attack – Home Secretary — RT UK
May 29, 2017 Brian Robert Hyland Leave a comment
MI5 has launched a probe into its own failure to flag the threat posed by the Manchester suicide bomber, Home Secretary Amber Rudd said.
TrendsManchester suicide blast
In an interview with Sky News, Rudd said the self-probe by the intelligence agency is "the right first step" in learning the lessons from last week's concert bombing.
"There is a lot of information coming out at the moment about what happened, how this occurred, what people might or might not have known. And I think it is right that the MI5 takes a look to find out what the facts are," she said.
The secretary added that in the future "we can look if anything else might need to be done" in terms of investigating the security breach, but stressed that at the moment, the focus should be on wrapping up the operation triggered by the May 22 terrorist attack.
✔@SkyNews
MI5 has launched urgent inquiries into how it missed the danger posed by the Manchester bomber. Home Secretary @AmberRuddHR explains
3:00 PM – 29 May 2017
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Earlier the BBC reported that the MI5 had been alerted about Salman Abedi's extremist views at least three times before he brought a home-made bomb to the exit of Manchester Arena last week.
It added that a separate report into the overlooked threat would be prepared for ministers and officials overseeing the work of MI5.
READ MORE: Members of Manchester bomber network may still be on the loose – UK home secretary
Abedi, a British-born man of Libyan descent, was one of 20,000 people identified by the MI5 as a threat, but not one of the 3,000 people who are under active investigation, according to a Reuters source.
On Monday, British police reported arresting the 16th individual suspected of connections with the Manchester bombing. The 23-year-old man was arrested in Shoreham-by-Sea, Sussex, "on suspicion on offences contrary to the terrorism act," Greater Manchester Police tweeted.
G M Police
✔@gmpolice
UPDATE: Man arrested in Shoreham by Sea in connection with Manchester Arena attack
11:45 AM – 29 May 2017
Two have been released without charge, while 14 men remain in custody for questioning, the police said.
READ MORE: 'Happy to hysterical in seconds': Witnesses recall Manchester Arena blast
On Sunday, the UK scaled down the terrorist threat in the country from "critical" to "severe."
The suicide bombing killed 22 people as young as eight and left 59 injured on May 22. The attack, for which Islamic State (IS formerly ISIS/ISIL) terrorist group has taken credit, is the deadliest in the UK since the coordinated bombings in London in 2005.
Source: UK MI5 intelligence to investigate itself after Manchester attack – Home Secretary — RT UK
Salman Abedi
#CIA, #ENEMEDIA, #FBI, #JFK, #KhazarianMafia, #SouthChinaSeaOilBlockade, FBI's Div. 5, Israeli Mossad(Read Mafia), lesser gods, MI5, MI6, Preston James, VETERANS TODAY, WARS
Subjects and Serfs of the Lesser Gods (Part I) | Veterans Today
Sep 7, 2016 Brian Robert Hyland Leave a comment
By Preston James, Ph.D on August 26, 2016
If you sleep with dogs you can get fleas. This is worse, much worse.
[ Note: If you have no interest or knowledge of background in Secret Space War matters, the secret and almost completely hidden machinations of the Top Chieftains of the Khazarian Mafia (KM), or the incredibly dark, evil, etheric non-corporeal entities which they serve in order to get their power, you are probably wasting your time reading this article. For those interested, this is a long article and you can save time by reading the bold print and then the conclusion. Doing this you will get the most important points of this article.
Thanks to a major world power shift that has occurred, the Khazarian Mafia (KM) has been significantly checkmated and is now being progressively and incrementally deconstructed. The KM's biggest secrets have historically been protected by their Controlled Major Mass Media (CMMM) which refuses to publish the facts of their extreme evil because the KM Moguls that run it follow KM policy that has been set by the KM Top Chieftains.
Instead of publishing the truth, the CMMM publishes KM big lies, false-narrative and USG propaganda, and by doing so has created a false social reality which makes the truth implausible to most. Since the KM assassinated JFK, this false reality has traditionally caused most Americans to view truth nuggets dispensed by the Internet's Alternative Media as mere "conspiracy theory" by whacky "conspiracy theorists".
Continue reading Subjects and Serfs of the Lesser Gods (Part I) | Veterans Today →
Doubles/Clones(Replacing The Cabal), John Lennon, MI5, MI6, Paul McCartney
Paul McCartney's Death in 1966 Goes Much Deeper Than an MI5 Replacement Operation | Celebrities
Aug 25, 2016 Brian Robert Hyland 2 Comments
Wednesday, August 24, 2016 6:26
Audio in video below:
TMR Editor's Note
Years prior to the The Millennium Report website going online one of our writers conducted exhaustive research into the "Paul McCartney is Dead" conspiracy. It is, in fact, a real conspiracy because of the number of willing participants who, by necessity, had to participate in it in order for it to be successful for almost fifty years.
However, only one element has been missing over the past 49 years. And that is a member of The BEATLES stepping forward to tell the unvarnished truth. It now appears that this little secret has been finally told by Ringo Starr. Certainly, with the death of his band mates, except 'Paul' of course, the burden of this secret became greater for him to carry alone as the years wore on.
Continue reading Paul McCartney's Death in 1966 Goes Much Deeper Than an MI5 Replacement Operation | Celebrities →
BEATLESRingo Star
#CIA, #MH17, Dutch Safety Board, Europe, Media - Liars, MI5, MI6, PRESIDENT PUTIN, RUSSIA, Ukraine, Washington DC (Cabal Military Arm)
MH-17: Russia Convicted By Propaganda, Not Evidence | Zero Hedge
Jul 18, 2016 Brian Robert Hyland Leave a comment
Authored by Paul Craig Roberts,
Today is the second anniversary of the downing of Malaysia Airlines Flight 17, and we still do not know the explanation.
Washington and its European vassal politicians and media instantly politicized the event: The Russians did it. End of story. After 15 months of heavy anti-Russian propaganda had imprinted the message on peoples' minds, the Dutch Safety Board issued its inconclusive report.
By then, it was irrelevant what the report said. Everyone already knew that "the Russians did it."
I remember when pre-trial media accusations resulted in dismissed cases. Anyone declared guilty prior to presentation of evidence and conviction was considered to have been convicted in advance and unable to receive a fair trial. Such cases were dismissed by judges.
Continue reading MH-17: Russia Convicted By Propaganda, Not Evidence | Zero Hedge →

redpajama_set_name: RedPajamaCommonCrawl


When A Family Of Two Become Three?
When you marry, you would be entering a new life. In this new life, you would have many pleasant memories, and there would also be certain challenges to face along the way. But you would not mind, because you would have your wife or husband to give you strength through everything. Life will go on, and slowly, you would find stability in life. The next big thing that could happen would be the birth of a child. Knowing that you are going to be a mother, or a father will make you really happy, and seeing your child will be one of the most memorable moments of your life. It would be necessary for you to understand that your life would change once a child is born. When a family of two becomes three, you would have to take the necessary steps towards making your home a place that fits all three of you.The safety of your child would be of primary concern in the first few months after birth. These months will allow you to adapt to your new roles, and then it would be just a matter of going on in your lives with the presence of your child. As a parent, you would always want to keep your child happy. You would be able to find many types of toys such as afterpay online shopping that would give your child the happiness that the child deserves. At the same time, you will have to ensure that you build a secure future for your child by going for valuable investments and making the house a better place through numerous additions.It is advisable to keep the child in your room until the child is able to sleep on their own. This would mean that the small bed your shared will not be enough anymore.
You would have to get a queen-sized bed and top quality queen bed frame to facilitate this, and it would be necessary for you to pay attention to other additions that would make your child more comfortable. Your child getting bigger would mean that you would be getting older, and it would be ideal if you ensure that you give your child the attention they need, as it would affect their psychological development.
With time, you may have more than one child, and these steps will have to be repeated again. All these would contribute towards you being a happy family, and your home being a place that will provide all of you with what you need in living comfortably.


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Quick Recap: Grizzlies fall short against Lakers
Memphis couldn't overcome the fourth-quarter takeover by LeBron James.
By Jesse Cinquini@CinquiniJesse Jan 3, 2021, 7:29pm CST
Share All sharing options for: Quick Recap: Grizzlies fall short against Lakers
Memphis faced off against the purple and gold, who held a 4-2 record heading into tonight's matchup. Grizzlies legend Marc Gasol made his long-awaited return to FedExForum. Here's how it all went down:
First Quarter: In the early going, the length of the Los Angeles Lakers frontcourt disrupted Memphis' offensive rhythm. The Grizzlies tried to punish Los Angeles in the paint, but this strategy was unsuccessful as the Lakers accumulated a number of blocks. Playmaker Dillon Brooks was on full display in the opening quarter — he dished out the first three assists of the game for Memphis. After a slow start shooting the ball for the Grizzlies, they went on a staggering 17-0 run to take a 28-18 lead, highlighted by a pair of spot-up treys from Desmond Bane and point-blank scores from Xavier Tillman . The Bears of Beale Street were sitting pretty at the end of one — they were up 36-25 behind 18 bench points.
Xavier Tillman gets the layup at the buzzer!
The Grizzlies closed the quarter on a 25-7 run, and are up 36-25 to end the quarter.
Bane - 8 points, 2 assists
Tillman - 6 points, 2 rebounds
Brooks - 5 points, 4 assists pic.twitter.com/8Q0xVPX82s
— Grizzly Bear Blues (@sbnGrizzlies) January 3, 2021
Second Quarter: Memphis' defensive effort was excellent to begin the second quarter. The Lakers had to wait until the halfway point to attempt their first free-throws of the game. Offensively, the Grizzlies continued to share the sugar and work for high-percentage shots on most possessions — they just couldn't find the bottom of the net. Unfortunately, they were plagued by cold shooting for the entirety of the second.
Los Angeles gradually cut into Memphis' advantage behind a scoring punch from their reserves, namely Montrezl Harrell and Talen Horton-Tucker. After owning an 11-point lead at the end of one, the Grizzlies were staring at a two-point half-time deficit. The Lakers decisively won the quarter 31-18.
Third Quarter: Memphis held Los Angeles' dynamic offense in check at the start of the second half — the Lakers opened shooting 0-for-5 from the field. Much of the third was a low-scoring rock fight— neither team could find cohesion or gain momentum due to high-level defense from both sides. Kyle Anderson stood out as the lone offensive bright spot for Memphis in the third, as he put nine points and one assist, which accounted for a majority of the Grizzlies' points in the quarter.
The Grizzlies and Lakers each scored 21 points in a period that both teams would like to soon forget. Los Angeles held a slim 77-75 lead with 36 minutes in the books.
end of the 3rd
Grizz 75
Anderson - 16 points
JV - 10 points, 7 rebounds
Bane - 10 points
Jones - 10 points, 5 rebounds
Brooks - 9 points, 5 assists
Fourth Quarter: LeBron James checked into the fourth quarter on a mission. He attacked the rim with an added aggressiveness and nailed a three-pointer so far beyond the line that even Trae Young would blush. James scored the first eight points of the period for the Lakers. The Grizzlies once again had a rough quarter scoring the ball, and the absence of Ja Morant was most glaring in the final frame. There was no player on the court for Memphis who they could hand the ball to time and time again during winning time, and they paid dearly for it. Los Angeles outscored Memphis 31-19 over the final twelve minutes and took home the victory, 108-94.
The Grizzlies will hope to split this mini series with the Lakers when the two teams face off on Tuesday back in FedExForum.


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Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
Friedrich G. Kapp1,2,3,
Julie R. Perlin1,2,
Elliott J. Hagedorn1,2,
John M. Gansner4,
Daniel E. Schwarz5,
Lauren A. O'Connell6,
Nicholas S. Johnson7,
Chris Amemiya8,
David E. Fisher9,
Ute Wölfle10,
Eirini Trompouki11,
Charlotte M. Niemeyer3,
Wolfgang Driever12 &
Leonard I. Zon1,2
Nature volume 558, pages 445–448 (2018)Cite this article
225 Altmetric
Evolutionary developmental biology
Haematopoiesis
Haematopoietic stem cells
Stem-cell niche
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour1,2. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by cmyb (also known as myb) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.
Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells
Annika Scheffold
, Ali H. Baig
… Martin D. Burkhalter
Leukemia Open Access 14 November 2019
Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney
Isao Kobayashi
, Mao Kondo
… David Traver
Scientific Reports Open Access 02 October 2019
Fig. 1: Melanocytes are spatially associated with the zebrafish kidney marrow.
Fig. 2: Melanocytes protect HSPCs from UV-induced DNA damage.
Fig. 3: UV exposure is detrimental to unprotected HSPCs.
Fig. 4: Melanocytes are present around the haematopoietic niche of aquatic animals.
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We thank D. Richardson at the Harvard Center for Biological Imaging for infrastructure and support; C. MacGillivray at the HSCRB Histology Core and Joyce LaVecchio at the HSCRB Flow Cytometry Core for technical assistance; E. van Italie in M. Kirschner's laboratory and J. Cech in C. Peichel's laboratory for providing Xenopus and stickleback samples; the Zebrafish Atlas (http://zfatlas.psu.edu/, NIH grant R24 RR017441, Jake Gittlen Cancer Research Foundation, and PA Tobacco Settlement Fund) for provision of the adult zebrafish histology image. Any use of trade, product or firm names is for descriptive purposes only and does not imply endorsement by the US Government. This work was supported by HHMI and NIH grants 5P01 CA163222, R01 HL048801, P01 HL032262, U54 DK110805-01, R01 DK053298, U01 HL100001-05, and R24 DK092760 to L.I.Z. D.E.F. acknowledges grant support from NIH (5P01 CA163222 and 2R01 AR043369) and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation. E.J.H. was supported by 1K01DK111790-01. Further support came from the German Research Foundation (DFG-SFB850-A1, to W.D.) and the Excellence Initiative of the German Federal and State Governments (Centre for Biological Signalling Studies EXC 294, to W.D.). F.G.K. was supported by a postdoctoral fellowship of the German Cancer Aid (70110820), a return scholarship of the Forschungskommission, Faculty of Medicine, University of Freiburg, and an EXCEL-Fellowship of the Faculty of Medicine, University of Freiburg, funded by the Else-Kröner-Fresenius-Stiftung. N.S.J. was supported by the Great Lakes Fishery Commission. E.T. was supported by funding from Max Planck Gesellschaft and a Marie Curie Career Integration grant (631432), a Fritz Thyssen Stiftung and the DFG founded Research Training Group GRK2344 'MeInBio – BioInMe'. L.A.O. was supported by a Bauer Fellowship from Harvard University. J.M.G. was supported by T32 training grants (T32CA009172-39 and T32HL116324-03).
Reviewer information
Nature thanks I. Beerman, G. Litman and S. Morrison for their contribution to the peer review of this work.
Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA
Friedrich G. Kapp, Julie R. Perlin, Elliott J. Hagedorn & Leonard I. Zon
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA
Department of Pediatric Hematology and Oncology, Center for Pediatrics, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Friedrich G. Kapp & Charlotte M. Niemeyer
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
John M. Gansner
US Fish and Wildlife Service, Private John Allen National Fish Hatchery, Tupelo, MS, USA
Daniel E. Schwarz
Department of Biology, Stanford University, Stanford, CA, USA
Lauren A. O'Connell
US Geological Survey, Great Lakes Science Center, Hammond Bay Biological Station, Millersburg, MI, USA
Nicholas S. Johnson
Molecular Cell Biology, University of California, Merced, CA, USA
Chris Amemiya
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
David E. Fisher
Department of Dermatology, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Ute Wölfle
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
Eirini Trompouki
Developmental Biology, Faculty of Biology, Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
Wolfgang Driever
Friedrich G. Kapp
Julie R. Perlin
Elliott J. Hagedorn
Charlotte M. Niemeyer
Leonard I. Zon
F.G.K. planned, executed or analysed all experiments. F.G.K. and L.I.Z. wrote the manuscript with input from all authors. J.R.P. and E.T. helped with a subset of in situ experiments, J.M.G. with flow cytometry, E.J.H. with a subset of imaging experiments and L.A.O. created the phylogenetic tree as well as the animal drawings. D.E.S., L.A.O., N.S.J., C.A. and U.W. provided essential materials and samples for the manuscript. W.D., C.M.N., D.E.F. and L.I.Z. supervised the project and gave input to experimental design. All authors discussed the results and commented on the manuscript.
Correspondence to Leonard I. Zon.
L.I.Z. is a founder and stockholder of Fate Therapeutics, Inc., Scholar Rock and Camp4 Therapeutics. D.E.F. has a financial interest in Soltego, Inc., a company developing SIK inhibitors for topical skin darkening treatments that might be used for a broad set of human applications. The interests of D.E.F. were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.
Extended data figures and tables
Extended Data Fig. 1 Melanocytes are spatially associated with the zebrafish kidney but dispensable for steady-state haematopoiesis.
a, Top right panel, schematic of an embryo. The black boxed area contains the kidney and is enlarged in the other panels. Left panel containing 4 images, zebrafish positive for Tg(cdh17:GFP) (green, labelling the kidney tubule) and Tg(runx:mcherry) (red, labelling HSPCs) are depicted at 7 dpf. The boxed areas in the left images are enlarged in the corresponding fluorescence panels in the middle; these panels show the head kidney containing the haematopoietic marrow (indicated by the dashed outline). The white arrow highlights the melanocyte umbrella. Scale bars,100 μm (bright field) and 50 μm (fluorescence). Bottom right panels, the kidney marrow of a 6-dpf larva positive for Tg(mitfa:GFP) (green, labelling melanocytes) and Tg(runx:mcherry) (red, labelling HSPCs) is shown from a lateral view (bottom right, large panel) and from an orthogonal view (transverse section; bottom right, small panel). The scale bar represents 20 μm. b, Whole-mount in situ hybridization of cmyb at different time points, a representative larva at 5 dpf is shown. Arrows indicate (from cranial to caudal) the thymus, the kidney and the caudal haematopoietic tissue; the enlarged portion of the image (dashed box) shows the thymus and the kidney. The experiment was performed with n = 10 wild-type and 10 mitfa−/− larvae at 5 dpf and 10 wild-type and 7 mitfa−/− larvae at 7.5 dpf. c, Flow cytometric analysis of the percentage of HSPCs that were positive for Tg(runx:mCherry) as a proportion of live cells in the kidney marrow of adult fish. Data are mean ± s.d.; n.s., not significant. d–f, Relative abundance of progenitors, myelomonocytes and lymphocytes in adult wild-type fish and mitfa, roy−/− and casper−/− pigment mutants as assessed by flow cytometry as previously described30. c–f, n = 6 wild-type, 6 mitfa−/−, 3 roy−/− and 4 casper−/− fish. Data are mean ± s.d.; analysis by ANOVA.
Extended Data Fig. 2 Unprotected haematopoietic cells accumulate DNA damage after UV irradiation.
a, Sorted cells that were positive for Tg(runx:mCherry) after anti-CPD immunostaining. Scale bars, 10 μm. b, Dot plot representation of data in Fig. 2b (quantification of immunostaining intensity per cell). Data are mean ± s.d.; for statistics and P values please refer to Fig. 2b. c, Magnification of the thymus (dashed red outline) after anti-CPD immunostaining (counterstaining with haemalum) after UVB irradiation at 5 dpf in pigmented and non-pigmented larvae. Arrows from above indicate melanocytes; arrows from below indicate examples of nuclei with DNA damage.
Extended Data Fig. 3 UV light is detrimental to exposed haematopoiesis.
a, Experimental layout. b, Reduction in HSPCs in larvae with and without PTU treatment as assessed by cmyb in situ hybridization after UVC irradiation. n = 26, 26, 24 and 19 larvae in from left to right. χ2 test. c, Reduction in HSPCs in tyr−/− larvae and their pigmented siblings as assessed by cmyb in situ hybridization after UVB irradiation at a UV index of 20. n = 38, 33, 29 and 38 larvae from left to right. Results were not significant but note that the pigmented irradiated group seemed to retain more HSPCs in this experiment than in the preceding experiments with a higher UV index. d, Histology of the kidney marrow two days after irradiation. The yellow outline represents the kidney tubules, the red outline shows the aorta and the green outline indicates the haematopoietic marrow. Note the reduced area of the haematopoietic marrow in the non-pigmented, irradiated larvae (bottom right). Scale bars, 20 μm. e, Abundance of thrombocytes positive for Tg(CD41:GFP) two days after irradiation. Each data point represents the number of thrombocytes per vessel area in individual larvae. n = 8, 7, 7 and 7 larvae for treatment groups from left to right. Statistical significance was calculated using ANOVA with post hoc Bonferroni's multiple comparison test, data are mean ± s.d. f, Schematic of the analysis of the number of thrombocytes that were positive for Tg(CD41:GFP). The boxed area represents the analysed area, in which the circulating cells were counted. The yellow outline represents the area of the vessel, which the number of circulating thrombocytes was normalized to.
Extended Data Fig. 4 Sunlight exposure in fish living in the wild.
Example of small fish swimming in clear and shallow water on a sunny day (photo taken at Titisee, Germany, July 2016). Field of view approximately 25–30 cm wide.
Extended Data Fig. 5 HSPCs relocated into the bone marrow before the transition to a terrestrial environment.
a, Top, a developmental time line of D. tinctorius. Tadpoles were staged according to Gosner34. Animals (from left to right) represent Gosner stage 25, 30, 41 and 42, as well as a froglet five days after losing its tail. Stage-specific histology analyses are shown in panels b–f as indicated. Bottom, the habitat of D. tinctorius at the different developmental stages. b–f, Haematopoietic niches analysed by haematoxylin and eosin staining. Scale bars, 100 μm (b–f) and 1 cm (a).
Extended Data Fig. 6 Cortical bone protects from UV-induced DNA damage.
a, Paraffin section of a D. tinctorius hind leg (from Extended Data Fig., specimen e) after irradiation with UVB post mortem; the leg was severed from the body and irradiated with UVB. The dashed outline represents the cortical bone. Note the higher staining intensity of the anti-CPD antibody in nuclei within the muscle tissue compared to nuclei within the bone marrow. This part of the leg is not yet haematopoietic (compare to Extended Data Fig. 5e, which shows the haematopoietic marrow in the other leg), but contains chondrocytes. Note that even the chondrocyte nuclei closest to the cortical bone are stained much less than the cells outside the cortical bone (arrows from below and from above, respectively). The triangle represents the direction of the UV source; white tip towards UV source. Scale bar, 50 μm. b, Quantification of grey scale values of nuclei inside (n = 17) and outside (n = 41) the cortical bone. Each data point represents the mean grey value of a 16 × 16 pixel circle inside the nucleus, the difference is highly significant (unpaired Student's two-tailed t-test, P < 0.0001); data are mean ± s.d.
Extended Data Fig. 7 Experimental setup during irradiation.
Fish were placed in a Petri dish inside the upper cardboard box to focus the light from above, because the Waldmann UV 801 BL unit has a curved lamp carrier. The lower cardboard box was used to place the larvae at the recommended distance from the lamps.
Extended Data Table 1 List of causes for lack of pigmentation
Supplementary Figure 1.
Flow cytometry gating strategy
Video 1 Melanocytes are spatially associated with kidney marrow HSPCs.
The kidney marrow of a 6 dpf larva positive for Tg(mitfa:GFP) (green, labelling melanocytes) and Tg(runx:mcherry) (red, labelling HSPCs) is shown from a lateral view (left panel). A 360° view was reconstructed using FIJI from the z-stacks
Source Data Figure 2
Source Data Extended Data Figure 1
Kapp, F.G., Perlin, J.R., Hagedorn, E.J. et al. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature 558, 445–448 (2018). https://doi.org/10.1038/s41586-018-0213-0
Issue Date: 21 June 2018
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text:
Q: Generating complex unitary matrix with a given column I'm looking for a way to generate a complex unitary matrix in which the last column is given. I will appreciate any tips and hints.
Thanks!

A: The Graham-Schmidt process can be used to orthonormalize a set of linearly independent vectors in any inner product space.  I assume the given vector $v$ is a unit vector, so not all its components are $0$.  Say entry $k\neq 0$.  Then make the fisrt $n-1$ columns equal to $$e_1,e_2,\dots,e_{k-1},e_{k+1},\dots,e_n$$ where $_k$ is the $k$th natural basis vector, so that the columns are linearly independent, and apply Graham-Schmidt.

redpajama_set_name: RedPajamaStackExchange


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From CNBC: Pre-Market Data and Bloomberg futures: S&P futures and DOW futures are down slightly (fair value).
Oil prices were up over the last week with WTI futures at $48.68 per barrel and Brent at $51.74 per barrel. A year ago, WTI was at $40, and Brent was at $40 - so oil prices are up about 25% year-over-year.
Here is a graph from Gasbuddy.com for nationwide gasoline prices. Nationally prices are at $2.29 per gallon - a year ago prices were at $2.00 per gallon - so gasoline prices are up about 30 cents a gallon year-over-year.


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Jan 15, 2001 Issue
Resident and Student Voice
Deep Waters
SCOTT C. CONLEY, M.D., Lancaster, Pennsylvania
Am Fam Physician. 2001 Jan 15;63(2):383-384.
"Let me warn you before we go into the next room," the physician whispered, "this woman is crazy!"
I stood in the hallway of the rheumatology clinic with a well-respected physician and was intrigued by his comment. As a third-year medical student, I was excited to have the opportunity to spend one-on-one time with this specialist. We were about to see a patient with severe rheumatoid arthritis. She was the last patient of the day, and I had already learned much from this physician.
Without further explanation, the physician strode into the examination room. I followed and was introduced to a normal-appearing woman in her late 30s who was sitting calmly in a chair in the corner of the room. I did not understand the physician's comment made earlier about the patient until I noticed an extremely large, black three-ring binder on the patient's lap, which she quickly opened as we sat down. The physician's eyes shot to the binder and then to me, indicating without words that the notebook was the source of his warning. Within this giant volume, the patient kept meticulous records of her illness—every blood test result, every radiograph finding and, seemingly, every word the physician had uttered. Without looking up, the patient grilled the physician for her recent laboratory results. What was her erythrocyte sedimentation rate? Rheumatoid factor titer? Complete blood count? Reluctantly, and with annoyance in his voice, the physician surrendered the information she requested.
The rest of the visit continued in the same manner, with the patient furiously recording information in her notebook and frequently interrupting the physician to ask questions. As we concluded the visit and left the room, the physician complained, "See, I told you she was crazy! And that notebook has started driving me crazy, too!"
The physician and I parted ways with a chuckle about the big black book and its obsessive owner. That night as I reflected on the encounter, I began to realize why maintaining the notebook was so important to the patient. The rheumatoid arthritis that she had was severe, and it represented a significant loss of control in her life. Using the notebook was her attempt to regain some of that control. There was not much she could do on her own to combat this disease, but she needed to feel that she was doing something. Chances are that she was not crazy; more likely, she was a normal person reacting to fears that anyone would face in her situation.
Illness does not occur as an isolated physical phenomenon in a person's life. In a broad sense, disease is not simply a disorder of bodily function or structure—it has far-reaching effects on the whole person. Disease can change relationships, alter priorities, challenge faith, raise fears and crush dreams. An illness like rheumatoid arthritis does not just erode joint and serosal surfaces, it encroaches on the spirit and soul as well.
Good and effective medical care goes beyond treating the physical aspects of disease. An old proverb notes, "The purposes of a man's heart are deep waters, but a man of understanding draws them out." The physician and I did not attempt to enter the deep waters of this patient's life to try to understand her loss of control or any of her feelings. We stayed on the shoreline of medical piety and called "crazy" what we did not take the time to understand. But there is more here than just an interesting empathic exercise for the psychologically inclined. A physician can actually achieve significant therapeutic benefit for a patient by addressing the manifestations of an illness that no stethoscope or laboratory test can detect. Simply put, there is healing power in words.
Stuart and Lieberman, in their book, The Fifteen Minute Hour,1 write, "By being able to engage the person psychologically while laying on hands in the process of examining the body, the physician is in a unique position to help the patient correct whatever disturbance in homeostasis has precipitated the visit to the doctor." I can often provide as effective a therapy for my patients by acknowledging the feelings of isolation and loss of control that accompany illness as I can by enrolling them in the latest study protocol.
During my residency, I have found these truths to be challenging but never more crucial. As I develop habits and perspectives that will likely last my entire career, it is easy to hide from patients behind biotechnology and medical jargon. Sleepless nights, busy schedules and unread journals make venturing into the deep waters appear inefficient and unproductive. Yet, is it? Do I not ultimately impede my own therapeutic recommendations by ignoring some of the more serious manifestations of my patient's illness? "Physicians are increasingly distancing themselves from the bedside," writes Dr. Bernard Lown in his introduction to Norman Cousins' book, The Healing Heart,2 "[they] are abandoning the power of the word as a therapeutic tool, and manifesting indifference to the patient's psychological and spiritual needs." All too often, the concept of the biopsychosocial model of medicine has remained just that—a concept.
BATHE Mnemonic
Stands for:
Suggested questions/statements
What is going on in your life?
Affect (the feeling state)
How do you feel about what is going on?or What's your mood?
What about the situation troubles you the most?
How are you handling that?
That must be difficult for you.
Information from Stuart MR, Lieberman JA. The fifteen minute hour: applied psychotherapy for the primary care physician. New York: Praeger, 1986.
How does a physician go about improving his or her ability to care for the whole patient? The BATHE mnemonic technique (see table),1 is an excellent and efficient method of engaging a patient on an emotional and psychologic level within the confines of a busy schedule. Begin with an initial background question ("What is going on in your life?"); move efficiently into a question concerning affect ("How does that make you feel?"); focus the patient on what is most troubling ("What bothers you the most about the situation?"); assess how the patient is handling the situation ("How are you dealing with this?"); and finally provide an empathic statement ("That must be difficult for you.") that enables a physician to convey to the patient that he or she has been heard and understood. As Stuart and Lieberman1 note, this feeling of simply being understood is intrinsically therapeutic for a patient.
Yet, the core of these concepts is not just another skill to be mastered but rather a perspective to be maintained. We treat people, not diseases. We should not lose our patients' humanity in the stacks of telephone messages and insurance forms crowding our desks. We should not allow our patients to become a list of ICD-9 codes in our computer databases. We should, instead, have the courage and insight to lift our eyes from their charts, take off our shoes and get our feet wet.
Scott C. Conley, M.D., completed his residency in June 2000. He is in private practice in Lancaster, Pennsylvania.
1. Stuart MR, Lieberman JA. The fifteen minute hour: applied psychotherapy for the primary care physician. New York: Praeger, 1986.
2. Cousins, N. The healing heart: antidotes to panic and helplessness. New York: W.W. Norton, 1983.
This quarterly department features essays written by medical students and family practice residents. Contributing editors are Jennifer Reidy, M.D., who is a resident at Lawrence Family Practice Residency, Lawrence, Massachusetts and is resident representative to the Family Practice Editorial Board; and Soni Nageswaren, student representative to the editorial board.
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DC Public Schools Closed Due to Power Outages
by Borderstan.com July 1, 2012 at 11:30 pm 1,014 0
From Rachel Nania. Check out her blog, Sear, Simmer & Stir. Follow Nania on Twitter @rnania, email her at rachel[AT]borderstan.com
News from Dupont-Logan-U Street
On Monday, July 2, DC Government offices will be open, but DC Public Schools will remain closed as DC continues to respond to power outages that resulted from Friday night's severe weatheras well as the extreme heat that has followed. Students and staff assigned to summer school should not report.
The Office of the State Superintendent of Education (OSSE) announced that all OSSE school bus service is suspended tomorrow – including transportation of children enrolled in non-public placements and in other jurisdictions. Fr more information, visit the DC Homeland Security department website and the DC Government website.
Get an RSS Feed for all Borderstan stories.
DC public schools, dc storm damage, June 29 storm
Pics: Friday Night Storm Damage in Borderstan Area
by Borderstan.com June 30, 2012 at 4:00 pm 1,451 0
The alley between T and U Streets on 13th Street NW: Six houses suffered wind damage from the late-night June 29 wind and rain storm. (Jerry Schultz)
See more photos of Friday night's storm damage in the Dupont-Logan-U Street area area on Flickr.
The wind gusts on Friday night, June 29, only lasted 10 to 15 minutes. But with wind gusts at 70-plus miles per hour, the brief wind storm, followed by a hard rain, did extensive damage in the DC metro area. The Borderstan area seemed to miss the worst of the storm damage, but there were still a number of downed trees and large tree limbs in local streets. What unusual was that residents in downtown areas who usually never lose their electric power did so Friday night. Some residents reported they still had power, but lost their Internet and cable connections.
Pepco power lines in the Borderstan area mostly underground, which means the neighborhood rarely looses power even when outer DC neighborhoods and suburbs do — trees cannot take down a buried power line. A quick drive around the Borderstan area showed large trees or large limbs down on a number of streets, including 13th Street NW just north of Logan Circle and at the intersection of New Hampshire Avenue and 18th Street NW.
Pepco serves customers in DC and Maryland, and according to a DC Alert, "Friday night's violent windstorm that ripped through the Washington area has devastated the Pepco electric system, leaving more than 443,000 of Pepco's 788,000 customers without power. Due to the widespread damage and the large number of outages, the power restoration effort is expected to take several days."
Across the Potomac in Virginia, Dominion Electric serves 831,000 customers in the Northern Virginia area and 367,000 were still without power as of 7:30 pm today.
You can sign up for alerts through Alert DC and get alerts by e-mail, cell phone, pager or wireless PDA. When signing up, you can select alerts on crime, transportation, utility outages/issues, government closings, breaking news, DC-sponsored events and Amber Alerts.
dc storm damage, June 29 storm