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Recorded classical music is a barely alive dinosaur
I used to read Gramophone and subscribed to it for quite some time. I cancelled my subscription 15 years ago and have not missed it. The main reason for the Gramophone's demise is simply that what represents the core of their interests, recorded classical music, is a barely alive dinosaur.
Classical music is better represented these days by live events. What makes the news is not a new recording of Beethoven's 9 symphonies by Chailly and the Gewandhaus but the fact that these artists are touring in many capitals around the world to perform them. TV with specialized channels like Europe's mezzo, Radio and Web-based radio, Web concert from concert hall acting as producers have replaced recorded music as the mean by which we discover and hear music. (I hate to quote myself but have a look here and here among many others …). Similarly, every Opera house is following the steps of the Met with their live relays in movie theaters.
Live Music is where things happen and technology has made It accessible and pervasive. Gramophone has not and cannot stay current with these media and is outdated. If you had to publish a magazine on computing, would it be on punched cards computing or on Ipad ?
Live events are much better served by specialized classical music reviews sites. The one where I contribute, Concertonet.com, regularly covers events in Paris, New York, Toronto, Geneva, Zurich, … Our readership is of 25 000 individual visitors every month. Musical coverage can also be found at other sites like this one. Comprehensive reviews are available there and include not only the major most visible events but also modern music, youth ensemble and newcomers and chamber music. What sites like Concertonet provide are reviews which provide in one month a quantity which would match what a major newspaper would publish on classical music for a full year.
Gramophone has attempted to extend its coverage to worldwide live events but in essence, it remains a UK centric reviewer of CDs and is thus destined to follow the path of punched cards computing magazine at the cemetery of dinosaurs.
That provocative response to yesterday's post came from fellow blogger and sometime guest contributor Antoine Leboyer. He may well be right that recorded classical music is a barely alive dinosaur. But if that is the case, despite sharing Antoine's preference for live music I have two concerns. Classical music must beware of becoming metro-centric, particularly as financially marginal touring becomes threatened by funding cuts. For those living outside urban areas recorded and broadcast music is a lifeline. As an example Dale added this pertinent comment to my recent post about independent record stores "For some of us, including myself here in rural North Dakota USA, the Amazon click has led to many musical experiences we'd otherwise not have had".
My second concern revolves around Dale's assertion that recorded music leads to many musical experiences we'd otherwise not have had. He is right and thinking back over the years my first experience of a number of artists who have changed my life, including Jordi Savall and Titi Robin, came via recordings, not live performances. Web streaming of live concerts may be a force to be reckoned with, but as yet it does not stray too far from mainstream classical repertoire.
But Antoine Leboyer is always worth listening to because his involvement with classical music comes through passion rather than profession. Which, perhaps not coincidentally, is the case for everyone of the many readers who have responded to yesterday's post. Putting both the Gramophone and BBC Radio 3 in the firing line in one article is clearly too much for those in the profession to handle. And talking of professionals, I generously described those attending Classical NEXT as the "great and good" of classical music. However Philip Amos, via a comment, provides a far more eloquent description:
It seems to me nothing more than a gathering of foxes who want to tell the chickens how to repair the henhouse the foxes wrecked in the first place. Well, the chickens have left and become free-range birds who know the problems that have been foisted on them (including by a certain rogue roosters of their own) and are showing great ingenuity in coming up with their own solutions, as you have recently and eloquently discussed in posts.
* The photo of Conlon Nancarrow in his studio complete with technology dinosaur comes from my 2007 post Best music of any late-20th century composer? When did you last hear Nancarrow's music in the concert hall?
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antoine leboyer BBC Radio 3 conlon nancarrow gramophone magazine Philip Amos Ricardo Chailly
Pliable said…
Email received:
small point, but there's a weekend coming up at the South Bank...
Also, if there's one composer who lends himself to recordings, I would have thought it would be him since much of it is literally mechanical.
http://ticketing.southbankcentre.co.uk/find/festivals-series/impossible-brilliance-the-music-of-conlon-nancarrow
Susan Scheid said…
Well, I am a member of the trousers rolled set, so probably my view here doesn't count for much, but I like my CDs, keep ordering more, and actually re-upped a long lapsed subscription to BBC Music Magazine, which I've found quite useful in selecting among recordings (its online archive, I will confess, as well as the hard copy magazine). It is true that there is nothing like live performance, and it's also true that I make increasing use of online/streaming services (Q2 Radio is terrific), but I do hope CDs will be around for a while, too. (I'm of course among the set who also loves real books . . .)
Joe Shelby said…
I agree that web streaming doesn't quite get away from the common rep (the Minnesota Orchestra's available streams are a prime case), but that is only a surface symptom.
The issue is that I'm not sure what you're asking for here. Yes, live music, in the hands of the right musicians in the right environment, is always superior. As Robert Fripp describes King Crimson works, the recording is "the love letter", the live event is "the hot date".
but in an age where there are a million other things to do besides go to a concert (most of them far cheaper), then concert attendance becomes a select event. As a select event it will get harder and harder to convince people to go out to hear something they've never heard before.
So the drive to make concert attendance the bigger thing over the recording actually goes against the progress of orchestral music: to keep them filling the halls, they will necessarily have to stick to the core repertoire, the stuff people know, so that people are willing to pay in time and money and get what they expect.
To insist that live performance dominates over all else is to call for the death of new music.
The only way around that is to give a sense of expectation to the potential concert goer a sense of what they will experience when coming to a concert that features new music, and the ONLY way to do that is to get them a recording of the music first.
Just like EVERY other aspect of the music industry has known for decades. Classical's insistence upon its structure where the recording is a maybe, and the likelihood of ANY repeat performance after a premiere is somewhere less than nil, will never go away so long as the notes on the page and the one premiere are all that matter. To get people interested in making the concert of new music an attractive thing, they have to get used to the new music, and the only, ONLY way to do that is to give them the ability to listen to the work at home, in the car, in the office, whatever. You have to make the modern music a part of their daily lives just as Beethoven and Mozart and Mahler have been, and then they can accept (just as they do with Mozart or Metallica) the idea of getting the better experience in the concert hall.
Unless they're specifically going to a concert for improvisation work (jazz and some forms of rock), nobody really goes to a concert to both hear something they've never heard before with the *expectation* of never hearing it again. It just doesn't sell.
I love new music (I have more recordings of music composed after 1890 than before it), but the idea of going to a concert where I can not hear the music again later just doesn't attract me at all. I want to know a piece, not just see it flash before me once, never to be seen or heard again.
LeoJCarey said…
I second your critique of Antoine's argument, as sincere and well-taken as his points clearly are. It's one thing to chide the major labels for their missteps, or to deplore the structure of the industry, but to write off the whole enterprise of recording? I don't think so. Four thoughts:
1) I'm a little suspicious when people involved in an enterprise tout its historical inevitability and its superiority to what it competes with/replaces. I believe that in finance this is known as "talking your book" -- offering a view that supports your own activities as it were disinterested appraisal.
2) As you say, not everywhere has sufficient density of music lovers to support even chamber concerts, let alone more expensive spectacles, like orchestral concerts or opera. Recordings offer performers a way to reach people they will never play for live. (And offer music lovers the chance to live in the hermetic solitude for which many of them are so eminently suited!)
3) Another perhaps related point is that the recorded repertoire is far more extensive than the performed repertoire any given year, so even a really thriving smulcast scene can't give you the richness of the back-catalogue of a thriving (or even barely thriving) record industry. The nature of the back-catalogue -- so many great performances of core repertoire -- has pushed performers to explore neglected work or to present repertory in unexpected juxtapositions. I think we all relish the results. By contrast, the exigencies of live performance tend to relate to trying to fill a hall with busy professional-class people at dinnertime. Creativity is possible, sure, but there's likely to be a preponderance of programmes that offer, say, Finlandia, Mendelssohn violin concerto, Dvorak 8. Even if you live in a cultural centre, there are fascinating pieces that you can wait a decade or more to hear live. (Things are even worse for opera fans: whole categories of the repertoire are essentially mothballed, with even concert performances a rarity.) But a decently distributed recording can create a viable -- albeit geographically dispersed -- listenership for a neglected work.
4) People love recordings; they love listening to a performance over and over that's exactly the same every time. They love playing it to their friends or discovering that their friends like the same recording. There are so many recordings I will always want to listen to, and I don't think I'm unusual: others, who have no interest in the music I listen to, feel the same about the music they listen to. Of course, recording is little more than century old, so this love is learned, and it can presumably be unlearned. But I question how quickly it could be unlearned, and note that even genres based on a reverence for live performance (bebop, say) have tended to preserve these performances, creating revered recordings, moments of immortality.
Strange times. Remember when every instrument case in the UK seemed to have one of those "Keep Music Live" stickers on? I say, Keep Music Recorded!
Leo Carey
What an informed response.
This blog struggles to do its readers justice.
Why lots of John Cage and any of Conlon Nancarrow if both were born 100 years ago?
Wurmbrand said…
A couple of further thoughts.
1.I would imagine that even if one lives in a large city, my chances of hearing the works of Edmund Rubbra live are very small, and yet he's one of the most important composers for me.
2.I'm not disagreeing with anyone about live performances, but one of the ways that music might matter to someone is as a very private experience for which headphones may actually be better suited. It's some years since I wrote a certain novella, but as I recall I felt that it owed something to music of Sibelius... probably in no obvious way... something that I likely wouldn't have become attuned to if I hadn't heard the music many times by myself.
Jean-Yves Duperron said…
You better watch out, that dying dinosaur may turn around and bite you.
The classical music recording business is far from being on the critical list. In fact, most of the better labels have never been so active. Mind you, if you are talking about the have-been majors, they lost track of what they were doing many years ago, and shot themselves in the foot by banking all their efforts on Andrea Bocelli or the Medieval Baebes.
I may be slightly biased here because I run my own website of classical music recording reviews, but I always have a treasure trove of new CDs to work on.
With streaming music, digital downloads, and live webcasts of operas and recitals, the industry is again hurting itself and doing a disservice to its followers by making everything too easy to access and turning it into a disposable commodity. They are stripping away the value of classical music. The anticipation of locating a great recording you've been looking for as vanished with the over-abundance.
And another thing. I've never seen the point of a live concert review.
The people attending that concert know if it was good or not, and the news is too late for those who were not there, because that performance has come and gone. A recording review on the other hand, serves a useful purpose. Another blogger used a Robert Fripp quote (the recording is "the love letter", the live event is "the hot date"). Fine, but the hot date lasts only a few hours and eventually fades from memory, while the love letter can be re-visited over and over again and in the process reinforces its message.
Jean-Yves Duperron
Philippa Schuyler - genius or genetic experiment?
A child prodigy fêted by Leonard Bernstein and Virgil Thomson, performed by five leading American orchestras while still a teenager, accompanied by the New York Philharmonic at age 16, ranked alongside Aaron Copland and Marc Blitzstein, mourned with a Pontifical Requiem Mass in St Patrick's Cathedral, New York, and the rumoured subject of a Hollywood biopic. That is the executive summary of an American musical legend who was born eighty years ago tomorrow. Child prodigies, anniversaries and even executive summaries are the common currency of classical music today. But there are several reasons why the story that is going to be told On An Overgrown Path over the next two days is important. The first is that the legendary figure was a woman who had a black father and white mother. The second is that she experienced the barriers to musicians of colour that still linger on today. And thirdly, despite her legendary status, until the second part of this feature appears tomorrow h
There is an awful lot of good music in C Major
My recent post sang the praises of the recording of English string music with Sir John Barbirolli conducting the legendary Sinfonia of London session orchestra. Rather confusingly, there is also an excellent long-standing permanent orchestra of forty professional musicians called the City of London Sinfonia . So this post switches Sinfonias but stays with English music to highlight another essential recording. In 2007 John Rutter made an important contribution to a Norwich Cathedral seminar on 'The Challenge of Contemporary Music', from which this extract is taken: I suppose I never really felt the need to venture into uncharted territory. I think in the end you have to speak with your own voice and there is a difference between being traditional and just copying what other people have done. I mean, we all see and hear quite a lot of second-hand music which... is just a pale imitation of what others have done. There is no mileage in that. I myself however always felt that it
Why is classical music selling itself short?
Data from the Office for National Statistics shows shows that the number of cases of depression among adults in Britain has doubled over the last twelve months. This means one in five people are exhibiting depressive symptoms compared with one in ten before the pandemic. Obviously an effective vaccine is needed. But, equally obviously, therapies are needed to counteract this alarming and overlooked increase in depression. In recent years authoritative neurological research has identified that classical music is medicine for the brain . Yet the classical music community is singularly failing to exploit these therapeutic powers, instead choosing to compete in the entertainment market . Why is classical music selling itself short in this way? In a booklet interview for the recording by the Boulanger Trio of the piano trio Canto Perpetuo by Peteris Vasks the composer proposes that : "...people go to the concert hall because they are looking for answers. Above all for a way o


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Home » News » Uncertain Economic Times Highlighted in Grant Thornton Mid-Market Summary
Global business optimism has fallen to a three-year low and economic uncertainty remains elevated, a mid-market business survey has shown.
The latest data released by Grant Thornton has revealed that uncertainty has led to 46 per cent of global business leaders identifying it as a constraint to growth, with general optimism in play at just 32 per cent of those questioned.
However, the latest bi-annual statistics, covering the first half of 2019, indicate a more positive outlook in other areas, highlighting resilience in exports and the Emerging APAC region, as well as a fundamental shift in investment behaviour away from capacity and into R&D.
The International Business Report (IBR) research, compiled from a quarterly global survey of 2,400 businesses in 36 economies, shows export optimism has held up well, despite a slowdown in trade growth, with expectations in the United States on the up. Less-developed countries also continue to defy the gloom with strengthened expectations for revenue and profit growth in the ASEAN mid-market.
While firms are generally scaling back investment in new capacity, such as new buildings, plant and machinery, R&D investment intentions are much healthier and tech investment intentions are proving robust – something which is especially relevant for emerging markets like Africa, emerging Asia and Eastern Europe.
The survey shows rising R&D intentions are not uniformly up across all sectors however. Financial services and business services have increased but TMT and consumer products have fallen in comparison with this time last year.
Among the other key findings in the report: • One-quarter of firms have identified trade tariffs as one of the most significant external barriers to international expansion. • Fewer companies are expecting to increase prices over the next 12 months, a move consistent with wider risks of weak inflation, particularly as global growth is slowing.
• There is growing concern over a shortage of finance, most notably for developing economies — the top five countries highlighting a shortage include Russia, India, Thailand, Argentina and Malaysia.
• European optimism held up well compared to the global average, falling modestly in the EU to 26% in H1 2019 from 28% in H2 2018. However, North American firms are the most optimistic about their country's growth prospects - nearly 70 per cent of businesses are 'slightly' or 'very' optimistic.
Richard Ratcliffe, a director of Grant Thornton in the Isle of Man, said while the report reveals interesting trends, it's clear the longer-term picture is far from certain amidst ongoing political developments.
'Obviously a major factor in some of this research is Brexit and the fact there is still no clear picture of what the future holds,' he said.
'More than ever before, whether in the Isle of Man or other countries, there is a need for businesses to be agile to benefit from sudden shifts in political and economic conditions elsewhere.
'Thankfully, the Island is an agile jurisdiction, and while our manufacturing industry is relatively small there are opportunities, as well as for companies engaged in other exporting industries.
'It is also encouraging to see some neighbouring countries with strong trade links riding a new wave of hope.'

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Reproduction: Angiosperm
Reproduction: Human
Inheritance Variation
Molecular Inheritance
Health Disease
Biotech Application
Chapter 13-16
12 Biology
Population Attributes
The group of members of a species in a well defined geographical area is called population.
Birth Rate: Number of live births per thousand members is generally taken as birth rate.
Death Rate: Number of deaths per thousand members is generally taken as death rate.
Sex Ratio: The ratio of females to males in a population is called sex ratio.
Age Pyramid: When the age distribution of population is plotted, the resulting structure on graph is called age pyramid.
Growing: When the population of pre-reproductive age group is highest, followed by reproductive and post-reproductive age group in that order, the age pyramid represents a growing population.
Stable: When the population of pre-reproductive age group is almost same as that of reproductive age group; followed by population of post-reproductive age group, the age pyramid represents a stable population.
Declining: When the population of pre-reproductive age group is lower than that of reproductive age group, the age pyramid represents a declining population.
Measurement of Population Size: Population size is generally measured in terms of population density, i.e. number per unit geographical area. But it is difficult to determine the absolute numbers in some cases. For example; there can be a solitary banyan tree in the midst of a huge lawn full of grass. Per cent cover or biomass is a more meaningful measure of the population size in this case. In some cases, indirect measurement is more practical way of assessing the population size, e.g. population of bacteria in a petri dish, or population of tigers.
Following factors affect the population growth:
Natality: The number of births during a given period in the population is called natality.
Mortality: The number of deaths in the population during a given period is called mortality.
Immigration: The number of individuals of the same species that have come into the habitat from elsewhere during the given time period is called immigration.
Emigration: The number of individuals of the population who left the habitat and gone elsewhere during the given time period is called emigration.
So, if N is the population density at time t, then its density at time t +1 is
Nt+1 = Nt + [(B + I) – (D + E)]
This equation shows that population density will increase if the number of births plus the number of immigrants (B + I) is more than the number of deaths plus the number of emigrants (D + E), otherwise it will decrease.
Growth Models:
Exponential Growth: Ideally, when resources in the habitat are unlimited, each species has the ability to realize fully its innate potential to grow in number. In this case, the population grows in an exponential or geometric fashion. If in a population of size N, the birth rates are represented as b and death rates as d, then the change in N during a unit time period t (dN/dt) will be
dN/dt = (b – d) × N
Let (b–d) = r, then
dN/dt = rN
The r in this equation is called the 'intrinsic rate of natural increase' and is a very important parameter chosen for assessing impacts of any biotic or abiotic factor on population growth.
Logistic growth: Resources are limited and there is competition for resources. So, exponential growth is not possible in practical situations. A given habitat has enough resources to support a maximum possible number. No further growth is possible beyond that number. This number is called the carrying capacity (K) of nature, for a particular species.
In a habitat with limited resources, the population growth initially shows a lag phase. This is followed by phases of acceleration and deceleration, and finally an asymptote.
A plot of N in relation to time (t) results in a sigmoid curve. This type of population growth is called Verhulst-Pearl Logistic Growth and is described by the following equation:
dN/dt=rN((K-N)/K)
N = Population density at time t
K = Carrying capacity
The logistic growth model is considered a more realistic growth model.
Life History Variation
Populations evolve to maximize their reproductive fitness in the habitat in which they live. This is also called Darwinian fitness. Under a particular set of selection pressures, organisms evolve towards the most efficient reproductive strategy. Some organisms breed only once in their lifetime, e.g. Pacific salmon fish, bamboo, etc. Some organisms breed many times during their lifetime. Some organisms produce a large number of small-sized offspring, while some others produce a small number of large-sized offspring. The life history traits of organisms have evolved in relation to the constraints imposed by abiotic and biotic components of the habitat.
Population Interactions
Interspecific Interactions: Interactions of populations of two different species are called interspecific interactions. Following are the various interspecific interactions:
Predation: Predaton is nature's way of transferring the energy (fixed by plants) to higher trophic levels. Apart from acting as conduits for energy transfer across trophic levels, predators play other important roles as well. Predators keep the population of prey under control. This helps ion preventing ecosystem instability. Predators also help in maintaining species diversity in a community. Prey species have evolved various defense mechanisms to lessen the impact of predation. Camouflage, thorns, poisoned armory, etc. are examples of such defenses.
Competition: Competition for resources can be between closely related species, or between entirely unrelated species. Competition is best defined as a process in which the fitness of one species (measured in terms of r) is significantly lower in the presence of another species. Recent studies suggest that species facing competition might evolve mechanisms that promote co-existence rather than exclusion. One such mechanism is 'resource partitioning. Species may choose different times for feeding or different foraging patterns.
Parasitism: Many parasites have evolved to be host-specific in such a way that both host and the parasite tend to co-evolve. If the host evolves special mechanism for rejecting or resisting the parasite, the parasite also evolves special adaptations to counter that mechanism.
Commensalism: This is the interaction in which one species benefits and the other is neither harmed nor benefited. An orchid growing as an epiphyte on a mango branch, and barnacles growing on the back of a whale benefit while neither the mango tree nor the whale derives any apparent benefit. The cattle egret and grazing cattle in close association, is a classic example of commensalism. When the cattle move, they stir up and flush out the insects from vegetation. Such insects would otherwise be difficult for egrets to find and catch.
Mutualism: This interaction confers benefits on both the interacting species. Lichens are classic examples of mutualism. Micorrhizae too are examples of mutualism. The relationship between plants and animals show fascinating examples of mutualism. Plants need the help of animals for cross pollination. In lieu of that, an animal gets nectar or fruit as food.


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Q: Sending PDF with Fast Web View in ASP.NET I am using ASP.NET 4.0 + IIS 7 to serve up a number of large PDFs via Response.TransmitFile.
The PDFs are all linearized, i.e. "Fast Web View". However the browser still requires the entire PDF to be downloaded before displaying any of it. All I want to do is show the first page (at least) without having to wait several minutes for the entire PDF to download.
From what I have read, the response header should include ["Accept-Ranges", "bytes"] but this does not seem to help.
Can anyone give me some pointers?
Thanks in advance!

A: I don't think you can do that easily. For byte range to work you would need many requests to serve the same file. How would you associate all these requests with a single file instance? You would probaly need to save the file to disk or somehonw maintain the file in memory... it could get tricky...
Much simpler would be to save PDFs in a shared folder (a first in first out cache) and let the HTTP 1.1 do the rest.

redpajama_set_name: RedPajamaStackExchange


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APPEARS IN Hunting
New Jersey: Fish and Game Council Adopts Updated Black Bear Management Policy
Support NRA-ILA
This week, the New Jersey Fish and Game Council approved an updated Comprehensive Black Bear Management Policy that would increase hunting opportunities and enhance public education on black bear encounters. Now, the proposal must be approved by the Department of Environmental Protection Commissioner Bob Martin before it appears in the New Jersey Register and is opened for public comment.
The updated management plan would open additional land in Northwest New Jersey for the harvest of black bears starting in this year. Beginning in 2016, New Jersey would add a six-day black bear season in October, with three of those days dedicated to bow hunting and the other three days for hunting with bows and muzzleloaders. The plan would also increase the black bear harvest limit to two bears per hunter, provided that one bear is taken in October and one in December. Furthermore, the plan focuses on the importance of public education efforts, trash management and research.
The NRA applauds the New Jersey Division of Fish and Wildlife for their extensive research of the past five bear hunting seasons. Conservation efforts such as this remain an important tool for the protection of our natural resources and proper wildlife management. By allowing sportsmen more opportunities to harvest bears and educating the public, this policy will help to control the number of human-bear conflicts and maintain a sustainable and healthy bear population.
New Jersey Hunting bow hunting
The legislature only just gaveled in this week and anti-gun legislators and gun control groups couldn't wait to reintroduce their extreme gun ban legislation - an "assault weapons" ban, Senate Bill 5217.
On January 3, the Biden Administration's Department of Justice (DOJ) announced that it would be finalizing a new rule on firearm storage for Federal Firearm Licensees (FFLs). The DOJ additionally announced an update to the Bureau of Alcohol, Tobacco, ...
On Friday, the Washington Senate pulled magazine ban legislation, Senate Bill 5078 to the Senate Floor where it is eligible for a vote for passage.
We mentioned a Beverly Hills gun shop last week in an article about the continued increase in background checks and gun sales. We spoke with the proprietor of that shop, and he offered a very humanized ...
It's no secret that crime in Chicago has reached levels not seen in decades. Crime statistics released by the Chicago Police Department (CPD) for October 2021 show significant increases in incidents of serious crime compared to the ...
Last week, two gun control advocates – who described themselves as a "crime analyst" and a "data scientist" -- published an article in the anti-gun publication The Atlantic blaming the 2020 spike in homicide rates on that ...
Bobby Timmons, director of the Alabama Sheriff's Association (ASA), is so opposed to acknowledging your inherent right-to-carry, and wants so badly to protect the revenue stream from permit fees, that he openly opposes the Second ...
On December 23, ATF launched a new system for applicants to complete various forms that ATF is responsible for administrating. For most gun owners, this change will primarily impact how applications for firearms regulated under ...
CAUTION: Federal and state firearms laws are subject to frequent change. This summary is not to be considered as legal advice or a restatement of law.
Yesterday, the House voted 64-29 to pass House Bill 1077, the lawful carry bill. It will now go to the Senate for further consideration.
UP NEXT x
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News by Matt Kim, News Editor
Nintendo announced a new Nintendo Labo Kit today and it's called the Nintendo Labo Vehicle Kit. Just like it says on the (cardboard) box the Vehicle Kit contains kits for a variety of vehicles including a car, submarine, and plane.
The full Labo Vehicle Kit also comes with a single pedal, two keys, and "more." Players will be able to change between vehicles by inserting one of the assembled Keys into any of the vehicles. All you have to do is pull out one of the keys and add another into the slot to transform your on-screen vehicle to another one.
The video games part of the Nintendo Labo Vehicle Kit includes a racing game, or battle cars equipped with extendable arms while also exploring a mysterious world. Each vehicle also features its own unique controls and special moves. A second key allows a co-pilot to come along for the ride.
Nintendo Labo car.
The Vehicle Kit will also be compatible with Toy-Con Garage, the special software that lets players build their own software and customization to the Labo Kits. Nintendo recently held a contest where they asked kids to submit their best custom Labo Toy-Con creations for special prizes.
Prior to the Vehicle Kit Nintendo offered two Labo sets, a Variety Kit with different cardboard toys like instruments and fishing rods; and a Robot Kit where players build a robot armor set. The cardboard kits interact with the video game on the screen. The Vehicle Kit is the first new kit announced since the launch of Nintendo Labo.
The Labo Vehicle Kit is available for pre-order for $69.99. For more, check out our Nintendo Labo guide for info on the first two Nintendo Labo Variety and Robot Kits.
More about Nintendo Labo
Matt Kim is a former freelance writer who's covered video games and digital media. He likes video games as spectacle and is easily distracted by bright lights or clever bits of dialogue. He also once wrote about personal finance, but that's neither here nor there.
PlayStation 5 Update Lets You Know If You're About to Play the PS4 Version of Game
Check yourself before you last-gen yourself.
Stardew Valley Just Got Beaches, Fish Tanks, Swimming Ducks, and a Whole Lot More
Nearly five years on, Eric "ConcernedApe" Barone just pushed what he says is Stardew's "biggest update yet."
Alien: Isolation Is Free on Epic and Just As Good as It Was in 2014
Get the motion tracker and don't go in the vents.
Shigeru Miyamoto Expresses Confidence in the Younger Generation of Nintendo
The legendary creator says the spirit will stay alive.


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http://uu.diva-portal.org/smash/person.jsf?pid=authority-person:17702
Kiflemariam, Sara
Publications (9 of 9) Show all publications
Morin, E., Sjöberg, E., Tjomsland, V., Testini, C., Lindskog, C., Franklin, O., . . . Claesson-Welsh, L. (2018). VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. Journal of Pathology, 246(3), 311-322
Open this publication in new window or tab >>VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
Morin, Eric
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Sjöberg, Elin
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Tjomsland, Vegard
University of Oslo, Department of Hepato-pancreato-biliary Surgery, Oslo University Hospital, Institute of Clinical Medicine, Oslo, Norway.
Testini, Chiara
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Lindskog, Cecilia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Franklin, Oskar
Umeå University, Department of Surgery and Perioperative Sciences, Umeå, Sweden.
Sund, Malin
Öhlund, Daniel
Umeå University, Department of Radiation Sciences, Umeå, Sweden ; Umeå University, Wallenberg Centre for Molecular Medicine, Umeå, Sweden.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Sjöblom, Tobias
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Claesson-Welsh, Lena
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
2018 (English)In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 246, no 3, p. 311-322Article in journal (Refereed) Published
Unstable and dysfunctional tumor vasculature promotes cancer progression and spread. Signal transduction by the pro-angiogenic vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) is modulated by VEGFA-dependent complex formation with neuropilin 1 (NRP1). NRP1 expressed on tumor cells can form VEGFR2/NRP1 trans-complexes between tumor cells and endothelial cells which arrests VEGFR2 on the endothelial surface, thus interfering with productive VEGFR2 signaling. In mouse fibrosarcoma, VEGFR2/NRP1 trans-complexes correlated with reduced tumor vessel branching and reduced tumor cell proliferation. Pancreatic ductal adenocarcinoma (PDAC) strongly expressed NRP1 on both tumor cells and endothelial cells, in contrast to other common cancer forms. Using proximity ligation assay, VEGFR2/NRP1 trans-complexes were identified in human PDAC tumor tissue, and its presence was associated with reduced tumor vessel branching, reduced tumor cell proliferation, and improved patient survival after adjusting for other known survival predictors. We conclude that VEGFR2/NRP1 trans-complex formation is an independent predictor of PDAC patient survival.
VEGF, neuropilin 1, pancreatic adenocarcinoma, trans-complex, branching
urn:nbn:se:uu:diva-363966 (URN)10.1002/path.5141 (DOI)000447161600007 ()30027561 (PubMedID)
Swedish Research Council, 2015-02375Swedish Cancer Society, CAN2016/578Knut and Alice Wallenberg Foundation, KAW 2015.0030Knut and Alice Wallenberg Foundation, KAW 2015.0275
Kiflemariam, S., Mignardi, M., Ali, M. A., Bergh, A., Nilsson, M. & Sjöblom, T. (2014). In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers. Journal of Pathology, 234(2), 253-261
Open this publication in new window or tab >>In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
Mignardi, Marco
Ali, Muhammad Akhtar
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics.
Bergh, Anders
Nilsson, Mats
Translocations contribute to the genesis and progression of epithelial tumours and in particular to prostate cancerdevelopment. To better understand the contribution of fusion transcripts and visualize the clonal composition ofmultifocal tumours, we have developed a technology for multiplexin situdetection and identification of expressedfusion transcripts. When compared to immunohistochemistry,TMPRSS2–ERGfusion-negative and fusion-positiveprostate tumours were correctly classified. The most prevalentTMPRSS2–ERGfusion variants were visualized,identified, and quantitated in human prostate cancer tissues, and the ratio of the variant fusion transcripts couldfor the first time be directly determined byin situsequencing. Further, we demonstrate concurrentin situdetectionof gene expression, point mutations, and gene fusions of the prostate cancer relevant targetsAMACR,AR,TP53,andTMPRSS2–ERG. This unified approach toin situanalyses of somatic mutations can empower studies ofintra-tumoural heterogeneity and future tissue-based diagnostics of mutations and translocations.
De två första författarna delar förstaförfattarskapet.
Bruzzese, F., Hagglof, C., Leone, A., Sjoberg, E., Roca, M. S., Kiflemariam, S., . . . Augsten, M. (2014). Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15. Cancer Research, 74(13), 3408-3417
Open this publication in new window or tab >>Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Bruzzese, Francesca
Hagglof, Christina
Leone, Alessandra
Sjoberg, Elin
Roca, Maria Serena
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics.
Hammarsten, Peter
Egevad, Lars
Ostman, Arne
Budillon, Alfredo
Augsten, Martin
2014 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 74, no 13, p. 3408-3417Article in journal (Refereed) Published
The tumor stroma is vital to tumor development, progression, and metastasis. Cancer-associated fibroblasts (CAF) are among the abundant cell types in the tumor stroma, but the range of their contributions to cancer pathogenicity has yet to be fully understood. Here, we report a critical role for upregulation of the TGF beta/BMP family member GDF15 (MIC-1) in tumor stroma. GDF15 was found upregulated in situ and in primary cultures of CAF from prostate cancer. Ectopic expression of GDF15 in fibroblasts produced prominent paracrine effects on prostate cancer cell migration, invasion, and tumor growth. Notably, GDF15-expressing fibroblasts exerted systemic in vivo effects on the outgrowth of distant and otherwise indolent prostate cancer cells. Our findings identify tumor stromal cells as a novel source of GDF15 in human prostate cancer and illustrate a systemic mechanism of cancer progression driven by the tumor microenvironment. Further, they provide a functional basis to understand GDF15 as a biomarker of poor prognosis and a candidate therapeutic target in prostate cancer.
Cancer and Oncology Medical Genetics
urn:nbn:se:uu:diva-229723 (URN)10.1158/0008-5472.CAN-13-2259 (DOI)000338341700005 ()
Weibrecht, I., Lundin, E., Kiflemariam, S., Mignardi, M., Grundberg, I., Larsson, C., . . . Söderberg, O. (2013). In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay. Nature Protocols, 8(2), 355-372
Open this publication in new window or tab >>In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay
Weibrecht, Irene
Lundin, Elin
Grundberg, Ida
Larsson, Chatarina
Koos, Björn
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab.
Söderberg, Ola
2013 (English)In: Nature Protocols, ISSN 1754-2189, E-ISSN 1750-2799, Vol. 8, no 2, p. 355-372Article in journal (Refereed) Published
Analysis at the single-cell level is essential for the understanding of cellular responses in heterogeneous cell populations, but it has been difficult to perform because of the strict requirements put on detection methods with regard to selectivity and sensitivity (i.e., owing to the cross-reactivity of probes and limited signal amplification). Here we describe a 1.5-d protocol for enumerating and genotyping mRNA molecules in situ while simultaneously obtaining information on protein interactions or post-translational modifications; this is achieved by combining padlock probes with in situ proximity ligation assays (in situ PLA). In addition, we provide an example of how to design padlock probes and how to optimize staining conditions for fixed cells and tissue sections. Both padlock probes and in situ PLA provide the ability to directly visualize single molecules by standard microscopy in fixed cells or tissue sections, and these methods may thus be valuable for both research and diagnostic purposes.
urn:nbn:se:uu:diva-199740 (URN)10.1038/nprot.2013.006 (DOI)000317109900009 ()
Grundberg, I., Kiflemariam, S., Mignardi, M., Imgenberg-Kreuz, J., Edlund, K., Micke, P., . . . Nilsson, M. (2013). In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics. Oncotarget, 4(12), 2407-2418
Open this publication in new window or tab >>In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
Imgenberg-Kreuz, Juliana
Edlund, Karolina
Micke, Patrick
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Sundström, Magnus
Botling, Johan
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools.
2013 (English)In: Oncotarget, ISSN 1949-2553, Vol. 4, no 12, p. 2407-2418Article in journal (Refereed) Published
Current assays for somatic mutation analysis are based on extracts from tissue sections that often contain morphologically heterogeneous neoplastic regions with variable contents of normal stromal and inflammatory cells, obscuring the results of the assays. We have developed an RNA-based in situ mutation assay that targets oncogenic mutations in a multiplex fashion that resolves the heterogeneity of the tissue sample. Activating oncogenic mutations are targets for a new generation of cancer drugs. For anti-EGFR therapy prediction, we demonstrate reliable in situ detection of KRAS mutations in codon 12 and 13 in colon and lung cancers in three different types of routinely processed tissue materials. High-throughput screening of KRAS mutation status was successfully performed on a tissue microarray. Moreover, we show how the patterns of expressed mutated and wild-type alleles can be studied in situ in tumors with complex combinations of mutated EGFR, KRAS and TP53. This in situ method holds great promise as a tool to investigate the role of somatic mutations during tumor progression and for prediction of response to targeted therapy.
urn:nbn:se:uu:diva-222138 (URN)24280411 (PubMedID)
Botling och Nilsson har delat sista författarskap.
Pena, C., Virtudes Cespedes, M., Lindh, M. B., Kiflemariam, S., Mezheyeuski, A., Edqvist, P.-H., . . . Ostman, A. (2013). STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research, 74(4), 1287-1297
Open this publication in new window or tab >>STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Pena, Cristina
Virtudes Cespedes, Maria
Lindh, Maja Bradic
Mezheyeuski, Artur
Edqvist, Per-Henrik
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
Birgisson, Helgi
Bojmar, Linda
Jirstrom, Karin
Sandstrom, Per
Olsson, Eleonor
Veerla, Srinivas
Gallardo, Alberto
Chang, Andy C. -M.
Reddel, Roger R.
Mangues, Ramon
2013 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 74, no 4, p. 1287-1297Article in journal (Refereed) Published
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis.
Kiflemariam, S., Mignardi, M., Bergh, A., Nilsson, M. & Sjoblom, T. (2012). Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes. Paper presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, JUL 07-10, 2012, Barcelona, SPAIN. European Journal of Cancer, 48(S5), S110-S110
Open this publication in new window or tab >>Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes
Mignardi, M.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Bergh, A.
Nilsson, M.
Sjoblom, Tobias
2012 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 48, no S5, p. S110-S110Article in journal, Meeting abstract (Refereed) Published
urn:nbn:se:uu:diva-194482 (URN)10.1016/S0959-8049(12)71133-4 (DOI)000313036500416 ()
22nd Biennial Congress of the European-Association-for-Cancer-Research, JUL 07-10, 2012, Barcelona, SPAIN
Kiflemariam, S. (2012). Expression and Mutation Analyses of Candidate Cancer Genes In Situ. (Doctoral dissertation). Uppsala: Acta Universitatis Upsaliensis
Open this publication in new window or tab >>Expression and Mutation Analyses of Candidate Cancer Genes In Situ
Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. Approaches that address this complexity and improve stratification of patients for treatment are therefore highly warranted. Thus, the aims of this thesis were to further develop and apply in situ technologies for expression and mutation analyses of candidate cancer genes to gain a deeper understanding of cancer biology and to study intra-tumor heterogeneity.
In paper I, we established and validated a procedure for scalable in situ hybridization of large gene sets in human formalin-fixed paraffin-embedded tissues for analysis of gene expression. This method was used in paper II for large-scale expression analysis of the tyrosine kinome and phosphatome, two gene families whose members are frequently mutated in many forms of cancers. Systematic, compartment-specific expression mapping at cell type resolution enabled us to identify several novel vascular markers that have gone unnoticed in bulk transcriptomic analyses. In papers III and IV, we used padlock probes for in situ mutation detection in single cells for studies of genetic intra-tumor heterogeneity. In paper III, multiplex detection and genotyping of oncogenic point mutations was demonstrated in routinely processed tissue materials, whereas in paper IV we further the application by demonstrating multiplex detection of fusion gene transcripts.
Collectively, the work presented in this thesis employs in situ-based methods to obtain spatial resolution of gene expression and mutation patterns in normal and cancer tissues, thereby broadening our understanding of the cancer genome.
Uppsala: Acta Universitatis Upsaliensis, 2012. p. 50
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 842
cancer, in situ, in situ hybridization, padlock probes, mRNA, tyrosine kinases, tyrosine phosphatases, fusion transcripts
Genetics Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
2012-12-21, Rudbecksalen, Rudbecklaboratoriet, Dag Hammarskjölds väg 20, Uppsala, 09:00 (English)
Nilbert, Mef
Lunds universitet, Institutionen för kliniska vetenskaper.
Pontén, Fredrik
Kiflemariam, S., Andersson, S., Asplund, A., Pontén, F. & Sjöblom, T. (2012). Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers. PLoS ONE, 7(3), e32927
Open this publication in new window or tab >>Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers
Andersson, Sandra
Asplund, Anna
2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 3, p. e32927-Article in journal (Refereed) Published
Tissue localization of gene expression is increasingly important for accurate interpretation of large scale datasets from expression and mutational analyses. To this end, we have (1) developed a robust and scalable procedure for generation of mRNA hybridization probes, providing >95% first-pass success rate in probe generation to any human target gene and (2) adopted an automated staining procedure for analyses of formalin-fixed paraffin-embedded tissues and tissue microarrays. The in situ mRNA and protein expression patterns for genes with known as well as unknown tissue expression patterns were analyzed in normal and malignant tissues to assess procedure specificity and whether in situ hybridization can be used for validating novel antibodies. We demonstrate concordance between in situ transcript and protein expression patterns of the well-known pathology biomarkers KRT17, CHGA, MKI67, PECAM1 and VIL1, and provide independent validation for novel antibodies to the biomarkers BRD1, EZH2, JUP and SATB2. The present study provides a foundation for comprehensive in situ gene set or transcriptome analyses of human normal and tumor tissues.
urn:nbn:se:uu:diva-174583 (URN)10.1371/journal.pone.0032927 (DOI)000303062000022 ()
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics (Closed down 2014-12-31)
Uppsala University, Science for Life Laboratory, SciLifeLab
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology


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Relatives of Patients with Myeloid Blood Cancer at Two-Fold Risk of Disease
Krista Rossi
Relatives of individuals with certain types of blood cancer may harbor inherited genetic changes that could influence their risk of developing diseases that arise from myeloid cells.
A team of scientists at The Institute of Cancer Research (ICR), in London, England, and the German Cancer Research Centre in Heidelberg, Germany, have found that relatives of individuals with certain types of blood cancer may harbor inherited genetic changes that could influence their risk of developing diseases that arise from myeloid cells.
The investigators postulate that their findings could assist in identifying individuals at greatest risk of these diseases and where genetic testing, medical observation, and counseling could be beneficial in the future. The data may also lead to new research that could decipher the genetic causes of myeloid blood cancers.
"Our study provides the strongest evidence yet for inherited risk for these diseases—evidence that has proved evasive before in part because these cancers are relatively uncommon, and our ability to characterize these diseases has, until recently, been limited," said lead author, Amit Sud, MBChB (Hons), MRCP, PhD, clinical research fellow at the Institute of Cancer Research, in a recent statement.
In an effort to discover whether an increased risk of blood cancers existed in relatives of patients, Dr. Amit and his team evaluated information pertaining to every patient diagnosed with myeloid diseases in Sweden, according to ICR. For their study, published in the journal Blood, the investigative team compared the occurrence of myeloid-type cancers and related diseases diagnosed in over 35,000 patients and 93,000 family members with cases diagnosed among the general population.
Overall, the team found that individuals were about twice as likely to develop myeloid diseases as those without a family history of the disease. Furthermore, they found that compared with someone from the general population, a first-degree relative of someone with myelodysplastic syndrome had around a 7-fold risk of developing the disease.
Investigators reported that risk varied depending on the type of disease. For instance, the standardized incident ratio (SIR) for first-degree relatives of patients with myeloproliferative neoplasm (MPNs) was 4.93%. For other myeloid cancers, the SIR was even higher; for polycythemia vera it was 7.66%, for essential thrombocythemia it was 6.75%, and for myelodysplastic syndrome it was 6.88%. Lower SIR values were noted for first-degree relative of patients with myeloid malignancies (1.99%), chronic myeloid leukemia (0.78%), acute myeloid leukemia (1.53%).
In all the disease types, the risk of first-degree family members developing the disease increased by up to 5 times if 2 or more documented cases of myeloid diseases existed within the family. Having a parent diagnosed with the disease at a relatively young age was an indicator of higher risk for relatives developing the disease.
The investigators concluded that the risk of myeloid cancers is passed on through families and is most likely to be attributed to inherited genetic traits passed on in DNA. However, the investigators noted that environmental factors shared in families could also play a role.
"In the future, our findings could help identify people at higher risk than normal because of their family background, who could be prioritized for medical help like screening to catch the disease earlier if it arises," Dr. Amit said.
News | Rare Disease Report®


Exped Downmat 7 Review – The Ultimate Sleeping Mat For Mountain Hunting?
I honestly never thought the day would come that I would willingly give up my Thermarest ProLite 4 sleeping mat. We've seen the day… I first heard about the Exped sleeping mat while on a trip to Wholesale Outdoor Sports in Nanaimo. Specifically, I was looking to see if they had a Thermarest "Neo Air" in stock so I could have a look at it.
The clerk said "Not yet… But have you ever heard of the Exped Downmats?"… He went onto say "I went on a camping trip a few weeks back and brought one of these along and it was the most comfortable sleep I've ever had outdoors".. "Oh… I said" not really taking much stock in his testimonial, but it did pique my curiosity enough to do some online research and what I found out quite impressed me.
The phone call came yesterday, and my Exped Downmat 7 had finally arrived in the store for pickup… The second good news was to find out it was on sale for $139.99 as opposed to the listed $169.95!
The reasoning for my decision was quite simple… The Exped Downmat 7 seems like a better product. This coming from a guy who's spent hundreds of nights over the last 20 years sleeping on Thermarests!
Seriously though… Look at the product specifications.
*R-Value is some scientific jargon that measures the transfer of heat through an object. The higher the number the better it's insulating properties.
For me personally… I don't mind packing the extra 7 ounces of weight. It provides nearly twice the insulation value and is also twice as thick which means I'm going to sleep warmer, and more comfortable.
Packed up side by side the Exped Downmat 7 is actually slightly smaller than the Prolite 4, which is interesting considering the Exped is also not cut to a taper for your feet like the Prolite 4. My Thermarest hasn't done me wrong, and it's held up in some pretty rough and rocky terrain the last few years and still has yet to spring a leak or fail me in anyway. The Exped Downmat 7 has big shoes to fill and with spring bear season fast approaching and sheep season in just a few months I will be trying the exped downmat out on a few planned trips and will be reporting back with a much more detailed review on this product.


text:
package metric_parser

import (
	model "github.com/Cepave/open-falcon-backend/modules/query/model/nqm"
)

func ParseToMetricFilter(dsl string) (model.MetricFilter, error) {
	if dsl == "" {
		return nil, nil
	}

	filter, err := Parse("Metric", []byte(dsl))
	if err != nil {
		return nil, err
	}

	return filter.(model.MetricFilter), nil
}

redpajama_set_name: RedPajamaGithub


Greetings to all James Blaylock readers - after years on the web we've been able to put together a variety of stuff on Blaylock, much of it thanks to generous contributions from people worldwide. If you have any comments or suggestions about the site they're always welcome - just send us an email.
For links to the Jan-Feb 2013 Aylesford Skull Blog Tour, with interviews and more, click here.


text:
Rhys's pieces
Still fondly remembered as Hugh Grant's slovenly flatmate, Rhys Ifans tells Mariella Frostrup why he's glad to be swapping Notting Hill for Nottingham
Sun 1 Sep 2002 06.25 EDT First published on Sun 1 Sep 2002 06.25 EDT
I've never seen a person flail into a room before but that's what Rhys Ifans is doing. He's not so much a body as a loose configuration of joints and limbs. Catweazle meets Dorothy's Straw Man. His career-launching role as Spike, Hugh Grant's hygienically challenged flatmate in Notting Hill , made him look positively beefy in comparison. As he lopes towards me I'm wondering whether he's remembered to put his legs inside his jeans. If he has, I'm having trouble locating them. Faded flares, black T-shirt, crumpled cream shirt and trainers. His long-term girlfriend Jess Morris, owner of fashion PR company Magnolia, has obviously failed to make an impact on his styling. No wonder he's had trouble living Spike down.
We're meeting in a pub garden near Ifans's north London home to talk about his latest role - in Shane Meadows's Once Upon a Time In The Midlands. But first we have to get the Notting Hill questions out of the way. A million female cinema goers faced their worst nightmare when Ifans burst on to movie screens as the spice in the Hugh Grant-Julia Roberts sandwich. Here was unreformed man at his most basic. Ifans's gift was to make him intensely lovable. So great was his impact in the part that he was squeezed on to the poster for Notting Hill at the last minute. The marketing people cleverly identified him as the film's secret weapon.
The 6ft 3in blond-haired, bilingual Welshman from Clwyd made an unlikely movie star, but there was no mistaking his luminosity. Since Notting Hill, he's delivered a series of memorable performances in mediocre movies, including The 51st State, Little Nicky and Rancid Aluminium (The exception being Lasse Hallström's excellent screen adaptation of The Shipping News. Even among a cast that included Kevin Spacey and Dame Judi Dench, Ifans dazzled.) The problem he maintains was that in the aftermath of Notting Hill, Spike was all anyone wanted him to play.
'Spike's taken a lot of shedding,' he says. 'I'll be eternally grateful to Richard Curtis (Notting Hill's writer), but I'll still put him in a headlock once in a while for doing it to me.' Five minutes with Ifans and I want to protest Curtis's innocence. I'm convinced Ifans can do more damage to himself than anyone else could hope to. He has the waxy, slightly sweaty pallor of a man who's had a late night too many. Then again it could be the effect of sitting in a beer garden in 30 heat. I'm not exactly dry myself.
Ifans is addictive company. He leans across the table conspiratorially and that's just to peruse the menu. He orders rice and beans, a dish he enthuses about at great length, augmented at the last moment by a side order of sardines. When the food arrives the rice and beans go untouched, while the sardines disappear in seconds. Further courses are forsaken for a stream of Marlboro Lights and a shared bottle of Pouilly Fumé. He mumbles and blushes when ordering it. It sounds unusually exotic in a broad Welsh accent. He should have voiced Clarence the Lion in 70s show Daktari. I could listen to him roll his rrr's all day.
Instead, I remind him that many actors benefit from playing the same role over again. His ex-co-star Hugh Grant, for example. 'I think he's a brilliant actor and he gets no credit for it. People take him for granted - pardon the pun. I think he's so skilled. A lot of my laughs don't happen until you cut back to Hugh. We're poles apart culturally but we share the same sense of mischief in real life.'
Nevertheless, he's exasperated that post Notting Hill, casting directors expected Spike, not Ifans, to pitch up and do a turn. But later, when he's posing for photographs and offers the photographer 'Cock out now or later?', I start to empathise with the casting agents. OK, he was being ironic, but the glimpse I get of the waistband of his black boxers which reads 'Playboy' and the large Elvis buckle on his belt don't help to distinguish him from his nemesis. Luckily his latest role does.
Once Upon a Time In The Midlands is set in Nottingham and is director Shane Meadows's quirky homage to the spaghetti Western. Again, despite a cast including Kathy Burke, Ricky Tomlinson and Robert Carlyle, it's Ifans who viewers will take to their hearts as he undertakes a blackly amusing rite of passage. He plays Dek, a socially inept boy-man who opens the movie by proposing unsuccessfully to his girlfriend Shirley on the Vanessa Feltz show. A garage owner who lives on a Nottingham housing estate, his dreams are encapsulated in a souped-up Ford he calls Baby. Dek's Top Man exterior, however, hides a huge heart, illustrated by his devotion to Shirley's 12-year-old daughter Marlene. His naive but happy existence is shattered by the arrival in town of Shirley's ex, a Glaswegian petty criminal played by Robert Carlyle on high smoulder. The title and Western-style opening theme have little to do with the story, apart from giving Carlyle the opportunity to walk into a series of velour-clad sitting rooms wide-legged and mean-lipped. Instead, it's a loving homage to Meadows's native town in a Mike Leigh 'lite' sort of way. Ifans sees the similarities: 'It's not as politicised as Mike Leigh became later, but I still think it's political in its warmth and honest interpretation of suburban England.'
The part of Dek immediately appealed. 'I liked Dek because he wasn't crazy, he wasn't like a firework-display cameo, which I get hired for a lot. He's a very normal guy while being quite extraordinary.' For those who remember Michael Crawford in Some Mothers Do 'Ave 'Em, Ifans's performance provides an occasional jaunt down memory lane. 'I grew up watching that show, so I'm sure some of Frank Spencer has rubbed off on me. It's a peculiarly English archetype. It's like Jesus in the wrong-sized sandals.'
At times, Ifans comes across as a paid-up member of the Luvvie Mafia. When he talks about responding 'to my needs as an actor at a given time', I'm reminded of a quote of his I've read. Can he really believe that 'the best thing about Britain is its actors'? I nearly find myself in a sardine shower. 'Fucking hell, man, plankton would come out with something more intelligent then that. Jesus Christ. Give me some credit. It might be my accent, but I think I'm the most misquoted actor in Britain. What I actually said is that the best thing about the British film industry is its actors, the worst the men in suits.' He lists further injustices at the hands of the British press. An ironic statement about wanting to play Shaggy in Scooby-Doo which was translated as fact and a night out where he was photographed and wrongly accused of snogging Kate Moss. As injustices go, it's hard to get too animated, so we move on to a subject that really makes him angry - his native Wales.
Rhys and his actor brother Llyr, with whom he starred in the Cardiff-set comedy Twin Town, were brought up in a Welsh-speaking household in the village of Ruthin, Clwyd where his parents were primary-school teachers. I ask him what being Welsh means to him. 'If a dog came in here now I'd converse with him in Welsh.' Then he warms to his subject. Arms waving about and nose sometimes just inches from mine he continues: 'It's more complex than just being Welsh. It's like a huge jigsaw with pictures on both sides and sometimes it's infuriating and sometimes it's pleasure and sometimes it arms you and sometimes it weakens you and sometimes it's a ball and chain, and sometimes it's a set of wings.'
I feel like I've just been treated to a virtuoso performance. Richard Burton meets Dylan Thomas in a Primrose Hill pub. It's not something he feels can be taken for granted, however.
'Welsh-speaking communities are under threat more than at any other time in history because of house prices. It's a delicate ecosystem and it's time that people in the Assembly realised that. Language is as important as any fucking ancient woodland. We've been speaking Welsh longer than any tree growing in Wales.'
Such is the zealous light now animating his greeny-grey eyes that having lived through the 'cottage-burning' 80s I can't help myself asking:
Have you ever felt like setting fire to a cottage?
'Yeah, yeah, absolutely yeah.'
But you wouldn't?
'No and even if I had I wouldn't tell you.'
Is it just me or does that seem an unnecessary follow-through?
He doesn't stop there. 'Communities that have been there for centuries are essentially becoming holiday villages. Young people are forced to leave because there's no work and the young people that are left can't afford to live there. That's a crime.' He brushes aside the suggestion that he can now be counted among those young economic migrants. Instead he's looking for answers.
'The alternative is what they've done in the Lake District. If you want to buy a home there you have to have lived and worked there for five years.'
It's seems unlikely Ifans would qualify. He's now 34 and has been living in London since his days as a student at Guildhall. 'I'll move back to Wales if and when I have children. I want them to speak the language I speak but I love living in London. It's my favourite city in the whole world. I love it because it's not England, it's London. I can buy rice and peas, even if I just sit and look at them.'
Ifans's interest in acting was sparked long before his arrival in London. He describes with a childlike sense of wonder the opening of Theatre Clwyd. 'It was just totally exotic. It was a spaceship. The most modern building in our county. It was like Babylon 5 and I was the guy who cleaned the space-station toilets. These actors would come in and out of North Wales. I got my first sense that there was somewhere outside my square mile. It was a total case of wanting to run away with the circus.'
But it wasn't just the architecture and a yearning for a world beyond Wales that enticed him into making his stage debut, as a rat, in a production of Toad of Toad Hall . 'The actresses were really tactile. Welsh women aren't the most tactile unless they're your relatives. And then you don't want them to be.'
He may have started out in the theatre but his experiences on the London stage seem to have put him off treading the boards. 'Even when an audience actually bothered coming I kind of felt lonely. I'm bright and I could probably talk most intellectuals under the table, but in the theatre there's this prerequisite that you have to be an intellectual. I didn't come from that world. On the other hand, most of my most enjoyable acting experiences have been in theatre.'
I suspect that part of his dislike of the theatre may have come from his own lack of confidence at the time. The bright boy from rural Wales with a big personality and an even bigger talent suffering a sort of 'cultural cringe', as Clive James so aptly named it. After 10 minutes of prodding, he reluctantly admits that the theatre did feel like a clique. 'I think there's a snobbery involved. You have to be a certain kind of person.'
What kind of person, I ask enthusiastically, thinking we may be on to something.
'Well behaved,' he beams, puffing on a fag and emptying his third glass of Pouilly Fumé.
Self-revelation is not Ifans's thing. His infectious enthusiasm makes almost any topic fuel for lively debate but in the spotlight of self-scrutiny he closes like a clam.
You said that the difference between an actor and a show-off is that an actor knows he's showing off and it's generally because he's frightened. So what are you frightened of?
Silence. For at least 60 seconds.
Finally he looks up. I notice his shoulders are set at a 45 angle. Left to the table, right to the sky. I didn't know a body was capable of such a sharp incline.
'It's probably... I don't know, I guess my silence is speaking volumes. I don't know. I don't know because I can't go there, probably.'
But isn't the whole thing about being an actor having to go there?
'Yeah, but I'm not acting now, am I?'
Well, act! (Me frustrated.)
'What do you want me to do, strip off to my pants?'
I could swear he's seriously offering this as his preferred alternative to answering the question. This from the same man who spent our first 10 minutes together telling me how much he'd like to lose Spike from his life. It's obvious that I'm sitting opposite a raggle-taggle mass of contradictions. He's wriggling so much I wonder if he's trying to escape his own skin. I like him and I'd like to strangle him. Ifans is currently insisting that he was a shy child. I suspect he's confusing shy with emotionally uncommunicative. He's eloquent and loquacious until asked anything personal.
'Shyness is invariably a suppression of something. It's almost a fear of what you're capable of. As a child I'd have these thoughts like when you stand over a bridge and want to jump. My shyness would be a way of not allowing me to act on that.'
What a comfort that must have been for his parents. Luckily for those who care about Ifans, he found a release in acting instead. 'It's strange,' he muses. 'In the theatre I was looking for what I found in film, and now I find myself in film and I'm trying to find what I discovered in the theatre. There aren't many odysseys in cinema for characters. As an actor now I'm looking for something darker.'
I hope he's given an opportunity to make that journey on screen rather than in life. Like fellow Welsh thespian Richard Burton, Ifans is, I suspect, carrying a self-destruct gene that's competing for his attention. Like Burton, Ifans has a rare talent. A gift that can turn the common man into a three-dimensional hero. As director Shane Meadows comments on his leading man: 'The beautiful thing about Dek's journey, and something Rhys has done very well, is to take a character from being something of a dork to being someone who stands up and is counted.' In an age when there are too many champions and saviours and men who rule the world, we do well to remember our next-door neighbour is as fascinating as any Hollywood superhero. Like Chaplin and Sellers, Ifans is an actor who can remind us.
· Once Upon a Time In The Midlands is released on 6 September.


text:
Driver freaks out after spotting ghostly figure in middle of road - and it's not first time it's been seen there
A dashcam has captured the moment a driver and his passenger spotted a "ghost" sitting in the middle of the road in an area famous for its spooky sightings.
As the car rounds a bend the figure can be seen up ahead in the centre of the road in a cross-legged or lotus position and the both men in the car start to sound a little panicky.
The driver immediately stops the vehicle and says: "Okay, that's a bit scary."
Then his passenger, who also sounds uneasy, says "Yeah," and adds: "That is very scary."
Without hesitating the driver then puts the car into reverse to get away from they think is a ghost.
The film was shot at night on a quiet road in the Malaysian capital of Kuala Lumpur between the areas of Taman Tasik Perdana and Bukit Tunku.
A further note of panic creeps in to the driver's voice as he says: "That's uh...uh...uh."
His passenger tries to calm him down, saying: "It's all right," as the clip ends.
After the clip was posted online, many other people said they had had similar experiences in the area.
Stories of the figure in the road go back 10 years, it is said locally.
But some locals said the figure in the road would have forced the car to stop if it had carried on in that direction and it was in fact someone planning to rob the car's occupants.
They said if the car had slowed down, accomplices would have jumped out from the shadows and mugged them.
The names of the terrified driver and his passenger were not reported, but they are thought to have continued their journey in a different direction without incident.
Labels: Ghost, Spirituality and Belief


The Wild Life is John Lewis-Stempel's account of twelve months eating only food shot, caught or foraged from the fields, hedges, and brooks of his forty-acre farm. Nothing from a shop and nothing raised from agriculture. Could it even be done? We witness the season-by-season drama as the author survives on Nature's larder, trains Edith, a reluctant gundog, and conjures new recipes. And, above all, we see him get closer to Nature. Because, after all, you're never closer to Nature than when you're trying to kill it or pick it. Lyrical, observant and mordantly funny, The Wild Life is an extraordinary celebration of our natural heritage, and a testament to the importance of getting back to one's roots – spiritually and practically.
In 1996 John Lewis-Stempel convinced his London-born wife to up sticks from the city and move to Herefordshire where his family have lived for five centuries. As well as hunting for wild food, he farms cattle and sheep. He is also the author of a number of books, including the recent The Autobiography of the British Soldier, reviewed by the Daily Express as 'What a book. Five stars'. He has two children.


text:
Without his best friend Charley, Tank Saddleton was left to work with two new engines who weren't very nice. They made fun of his glasses, but when Tank took them off, it made things even worse. Follow Tank on his adventure, as he deals with bullies who ultimately learn that it's important to always be
Without his best friend Charley, Tank Saddleton was left to work with two new engines who weren't very nice. They made fun of his glasses, but when Tank took them off, it made things even worse. Follow Tank on his adventure, as he deals with bullies who utlimately learn that it's important to always be kind.
Be the first to review "The Adventures of Charley McChooChoo: Tank's Glasses by Trevor Davis" Cancel reply


text:
Q: How to make a falling curtain effect like this in CSS How do you make an effect like this. I'm pretty new in CSS animations and I don't actually know where to start. I do now this, it's a hover so you'll probably need a transition to trigger the effect. I also know the photo should have a static position and the blue div should have a relative position. From here on, I have no idea where to start. Anyone who can help me out? Thanks!

A: I hope this helps you.

.img_wrap {
  position: relative;
  width: 300px;
  height: 350px;
  overflow: hidden;
}
.img_wrap img {
  width: 100%;
}
.img_details {
  padding: 15px;
  font-size: 18px;
  font-weight: bold;
}
.left {
  float: left;
}
.right {
  float: right;
}
@keyframes elastic {
  0% {
    transform: rotate(90deg);
    opacity: 0;
  }
  50% {
    transform: rotate(-30deg);
  }
  100% {
    transform: rotate(0deg);
    opacity: 1;
  }
}
.overlay {
  position: absolute;
  top: 0;
  left: 0;
  width: 100%;
  height: 100%;
  background-color: lightblue;
  color: #fff;
  font-size: 30px;
  font-weight: bold;
  display: flex;
  align-items: center;
  justify-content: center;
  opacity: 0;
  -webkit-transition: all .2s ease-in-out;
  transition: all .2s ease-in-out;
}
.img_wrap:hover .overlay {
  opacity: 1;
  -webkit-transition-delay: 0s;
  transition-delay: 0s;
  transform-origin: top left;
  transform-style: preserve-3D;
  transition: transform 1.5s linear;
  animation: elastic 1.5s forwards;
}

Santa toy
3$

Sold out

A: You should really try to learn and tweak it around and try to come up with it on your own but here's this anyways.Hope, this helps.

#a,
#b {
  width: 300px;
  height: 300px;
  background: red;
}

#b {
  opacity: 0;
  background: blue;
  transform: rotate(100deg);
}

#a:hover #b {
  transform-origin: top left;
  transform-style: preserve-3D;
  transition: transform 2s linear;
  animation: mymove 2s forwards;
}

@keyframes mymove {
  0% {
    transform: rotate(90deg);
    opacity: 0;
  }
  60% {
    transform: rotate(-30deg);
  }
  100% {
    transform: rotate(0deg);
    opacity: 1;
  }
}


Winter Driving, a new course launched by the Mercedes-Benz Driving Academy at Mercedes-Benz World in Weybridge, is specifically designed to ensure that even the most seasoned driver is prepared for the dangers and demanding road conditions that the winter brings. Road accident figures show casualties soar in the winter months, with November 20091 having the highest number of serious 2 accidents on Britain's roads, closely followed by December.
Through the expertise of the Driving Academy, the course gives practical advice with invaluable experience of driving on surfaces with very low grip. The specialist Wet Skid Circle and Straight at Mercedes-Benz World replicates icy weather conditions, enabling drivers to experience real life skid situations first hand, but in a safe and controlled environment, with expert guidance from a qualified Mercedes-Benz Driving Academy coach. This allows drivers to understand how their actions can cause the car to lose control, how to regain control, and the steps to prevent it happening in the first place.
The course runs exclusively through the Mercedes-Benz Driving Academy, and applies the latest techniques to equip every driver with the essential skills via one-to-one coaching. The course benefits all drivers; new, experienced, elderly or anyone who has had a bad experience in the past - allowing them to protect themselves, their car, and their insurance premiums during the dangerous months. The practical side of the course ensures drivers are briefed and prepared for every eventuality, including basic tips like ensuring the car is loaded with blankets, spare food and water, and a torch in the event they get stuck in poor weather.
The Winter Driving Course is an extension of the Mercedes-Benz Driving Academy, which launched in 2009. Offering three main modules: Pre-road module (age 12 – 16yrs), Provisional Licence module (age 17+yrs) and Post-test module (for those who have already passed their test). With the handling circuits at Mercedes-Benz World, in Weybridge, Surrey, students as young as 12yrs can enrol in the Driving Academy and start mastering driving skills in a safe environment off the public roads, under the expert tuition of certified personal coaches. This allows them to get familiar with the car, gain confidence and focus on controlling the car before they have to deal with traffic situations out on the public roads. Concentrating on one thing at a time in a stress-free environment eventually leads to more effective learning and better driving habits.


A Pakistani teenager who was injured in the horrific attack on a school in Peshawar in December will undergo life-changing surgery at the same Birmingham hospital where teenage activist Malala Yousafzai was treated.
Ahmed Nawaz, 15 suffered life-threatening injuries in the 16 December attack on the Army Public School in the northern Pakistani city.
His brother was among the 141 people – 132 of them children – massacred by Taliban gunmen.
Ahmed was shot several times and has been unable to use his left arm.
He arrived in the UK on Friday and will undergo treatment at the Queen Elizabeth Hospital in Birmingham, the same facility where education activist Malala Yousafzai underwent life-saving treatment after she was shot by the Taliban in 2012.


Orscheln Products, a global leader in motion control systems, offers mechanical shift control systems in a standard mechanical and electro-mechanical shift control product line. These systems are available for the Allison® 1000, 2000, and 2400 series transmissions. The mechanical shift control systems from Orscheln Products are designed around the "Felsted™ Shifter" platform or the "NG" platform and are available for standard, inhibitor, and/or interlock shift applications. The shift levers in Orscheln's mechanical shift control systems are available in side push button, t-handle release, and top push button configurations. If one of Orscheln Products' standard mechanical shift control systems do not meet a customer's specific needs, a team of engineers is capable of creating a custom solution.
For more information about mechanical shift control systems from Orscheln Products, please contact the Sales Team today.


The Hawkers Joint Action Committee meeting held on 21st April, 2013 at the Sindhu Samaj Hall, Karolbagh unanimously decided to form fronts of Women and Minorities.
Md. Sayed, Hawkers representative of Badarpur Market and resident of Daryaganj was elected as convenor of the Minority Front.
Ms. Sushma, a member of the Zonal Vending Committee of North Delhi Municipal Corporation, Hawkers representative of Karolbagh and resident of Nawada, Dwarka was unanimously elected as Convenor of the Women Front of the Hawkers Joint Action Committee.
More than 100 hawkers representatives who participated in the meeting discussed issues including of newly elected Hon'ble Mayors and Standing Committee Chairpersons in all the three municipal corporations of Delhi. A detail discussion took place on the Food Safety and Standard Act and required interventions by Food vendors.
Hawkers Joint action Committee also decided to actively participate in the forthcoming national convention on FDI in Retail.


When craving sushi East Peoria IL residents can now just take a short drive to Junction City. Amid all of the popular day and night spots, Novu Sushi provides craft cocktails, steaks and, of course, sushi! We don't just have regular sushi though; our premier sushi is made by an experienced Tokyo, Japan chef.
Authentic Sushi East Peoria IL Will Love!
The celebrated Japanese delicacy is enjoyed all over the world, but there are some flavors and spices only available in larger cities, such as New York, L.A. and Tokyo. Thanks to Novu Sushi, that is no longer the case. Our owners searched far and wide for the best sushi chef there is, and they found our Master Chef, Kumiko Osamato.
Kumiko brings all that she learned from the high-end, fast-paced world of Tokyo, Japan sushi restaurants to East Peoria and Peoria residents. The Peoria area will love her authentic sushi dishes and our laid-back atmosphere. You will come for the sushi, but stay for the craft cocktails, fine wines, seafood, steak and desserts, such as crème brûlée.
If you dine with Novu Sushi, you will have a wide range of delicacies to choose from. When it comes to sushi East Peoria IL residents will be pleased to know that our menu is not on the light side. We offer rolls with cooked ingredients, rolls with uncooked ingredients and vegetarian rolls. Follow us on Facebook and Twitter to get regular updates on our menu, happy hour and featured dishes!
With indoor dining under our purple lights and outdoor dining under the blue sky, Novu Sushi is ready to serve you. Call us to reserve your spot today and guarantee a meal you won't soon forget. If our mouth-watering photo gallery doesn't tempt you, then maybe our full menu of sushi, drinks, entrées and desserts will!


Did the summer just fly by you in the blink of an eye? It did for me too but I'm just fine with that because my favorite time of year is almost here. Not only is October my birthday month but it starts getting cooler, all the colors of fall start to emerge and of course we have Halloween. This year Philosophy has a new set to help us get in the Halloween spirit, their new Haunted House set.
mmm that caramel apple looks lilke it smells really good!


A pantry concept serving food handmade from scratch. Menu includes fresh and frozen entrees, sides, dips, snacks, soups, stocks/sauces, pizzas, hors d'oeuvres, cookie dough and signature Chocolate Ganache Brownies. Along with fresh items, find varying weekly offerings. Visit website for current menu.