Can anybody help me with this situation.
I have a situation where gold or Silver members can send messages to any members irrespective of weather they are in the friends list or not of the receiver.. An option which we have in osdate 2.5.
In Evo We first have to send the friend request and if the member accepts the request then the user can send messages but in my case I dont want this friend request scenario.Simply able to send messages to anybody based on the packages.
at changing it for osDateEvo?
Looks like you have not understood what I said..
Basically in osdate there is NO concept of friend request hence members were able to send messages to anybody.
Now in Evo we have this SEND friend request and accept request then able to send or receive messages. This function I don't want.
Thanks for correcting me, this was put in to stop the spamming of members.
You can undo the Spam protection just by downloading the correct compose.tpl file attached below.
These files disables the Friends Mod where you can only message your contacts in your friends list.
We are not responsible in any way for any spam reports made to your domain in any way!
If you use these files at your request, you use them at your own risk by disabling the Spam Security.
Default Compose Templates Only is for the basic Default templates only.
FreshDate Compose Template Only is for FreshDate templates only.
osDMix Compose Template Only is for osDMix templates only.
But your files don't exist anymore.
this patch works well, but it's definitely remove captcha (spam code) when user send a message.
How can I reactivate this captcha ?
replace 7 into RoleId'] < '7' by your membership premium ID.
Does that code change just add the captcha back to the send a message?
As I removed it because members don't like using the captcha and it wasn't broken.
I needed it back for my "free member", it's one of argument to become PREMIUM (no more spamcode, no ads, and some others stuff) .


In Hollywood, it's all about who you know. That's true even if you're not trying to become a star – even if you're just hoping to enjoy a night of close-up magic. The Magic Castle, a clubhouse where magicians perform for guests each night, is a place that few Los Angeles residents ever get to visit. It's a tough ticket, and it comes with conditions. Only members of the Academy of Magical Arts and invited guests are allowed in. Guests are required to pay a door charge of $25 to $35 and pay for a meal while visiting the Magic Castle, and everyone must follow the castle's strict dress code. But all that effort is worthwhile if you can get into this truly one-of-a-kind venue.
If you're lucky enough to know a member of the Academy of Magical Arts, the good news: You know someone cool, and you have an in for the Magic Castle. Unfortunately, this won't apply to the vast number of tourists who arrive in LA, but it's worth asking around. Post a message on your social media pages asking if anyone knows a member who might be willing to get you in. Members get an unlimited number of guest cards that allow up to six people to visit the castle, and the member doesn't even have to attend. Members are also allowed to bring an unlimited number of guests with them when they visit the castle.
Don't know any local magic lovers? Visitors can buy their way into the Magic Castle by staying next door in the Magic Castle Hotel. It looks like a motel from the street, but it's actually a well-rated hotel with a number of amenities and close proximity to the heart of Hollywood. The hotel is separate from the castle itself, but the hotel's staff are able to make reservations for guests to get in – assuming the castle has availability on the night you want to visit.
Make sure to book your hotel room directly or through a travel agent, because this perk isn't available to people who book their reservations through third-party services. Call or email the hotel before booking your room to make sure the castle has availability while you'll be in Los Angeles.
Becoming a member isn't a feasible option for many people, and it's not a last-minute or very affordable process. But people who have a love of all things magic may get a lot of value out of joining the Academy of Magical Arts. Once accepted, members can visit the Magic Castle any time it's open and invite guests along.
The academy offers two membership options, one for magicians (who must audition to be accepted) and one for non-magician "associates." Becoming an associate member typically involves adding your name to a wait list and paying an annual membership fee that's rumored to cost several hundreds of dollars. The academy offers non-resident memberships, which are available to people who live more than 60 miles away from the Magic Castle.
Walsh, Kathryn. "How to Get Into the Magic Castle in Los Angeles." Travel Tips - USA Today, https://traveltips.usatoday.com/magic-castle-los-angeles-62965.html. 15 March 2018.


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text:
Q: PHP inside HTML attribute I am looking for some help putting some PHP code inside an HTML attribute. I can't seem to make it work. I think I am escaping the quotes incorrectly or the php is not being concatenated with the html, but I can't seem to figure out. Can someone please offer some advice. Should I put the HTML inside php string and echo is out that way?
<?php $icon_hospital = htmlspecialchars('http://s15.postimg.org/6ct1w2o5z/hospitals.png'); ?>
<?php echo $icon_hospital; ?>

<img src="https://maps.googleapis.com/maps/api/staticmap?size=400x400&markers=icon:"<?php echo $icon_hospital ; ?>"%7CAlbany,+NY&sensor=false">

A: Use urlencode() instead of htmlspecialchars() and dont use quotes within the url:
<?php $icon_hospital = urlencode('http://s15.postimg.org/6ct1w2o5z/hospitals.png'); ?>
<?php echo $icon_hospital; ?>

<img src="https://maps.googleapis.com/maps/api/staticmap?size=400x400&markers=icon:<?php echo $icon_hospital ; ?>%7CAlbany,+NY&sensor=false">

A: Try removing the double quotes from the php code in img src.
<?php $icon_hospital = htmlspecialchars('http://s15.postimg.org/6ct1w2o5z/hospitals.png'); ?>
<?php echo $icon_hospital; ?>

<img src="https://maps.googleapis.com/maps/api/staticmap?size=400x400&markers=icon:<?php echo $icon_hospital ; ?>%7CAlbany,+NY&sensor=false">

A: Use rawurlencode()
<?php $icon_hospital = rawurlencode('http://s15.postimg.org/6ct1w2o5z/hospitals.png'); ?>
<?php  echo $icon_hospital ; ?>
  <img src="https://maps.googleapis.com/maps/api/staticmap?size=400x400&markers=icon:<?php echo $icon_hospital ; ?>%7CAlbany,+NY&sensor=false">

http://php.net/manual/en/function.rawurlencode.php

redpajama_set_name: RedPajamaStackExchange


Here's a step by step guide to download and install macOS Sierra on Windows using VMware virtual machine.
VMware is a virtualization software that allows multiple operating systems to run on a single machine. On a Windows machine, it means that you can install any operating system that is originally not supported such as macOS Sierra 10.12.
Some of you might want to install macOS on your Windows machine for various reasons. Maybe your favorite program works on Mac only or you wish to develop apps for iOS or macOS and therefore require XCode. Whatever the reason is, it is quite easy to install macOS on your Windows machine using VMWare.
In this detailed guide, we will show you how to install the latest macOS Sierra 10.12 on Windows using VMWare virtual machine.
If you get an error stating that the download limit has reached, you can fix it by copying the file into your own Google Drive. Right click on the file and select 'Make a Copy'. Choose 'My Drive' from the left menu. Once copied, download the file from your drive.
Step 2: Download and Install VMware Workstation or VMware Player. You can get started with the trial version if you don't want to purchase it.
Step 3: Extract the macOS Sierra .rar file to a folder. To do so, place it within a new folder and then right click on the .rar file and choose Extract Here.
Step 4: Unzip the Patch Tool file downloaded in step 1 and open its folder. Right click on win-install.cmd file and select 'Run as administrator'. For this step to be successful, VMware should be installed on your PC.
Open VMware Player or Workstation (download it if you don't have it) and select "Create new virtual machine".
For 'Guest operating system', choose Apple Mac OS X and then for the Version, select OS X 10.11 or OS X 10.12.
Enter a name for the virtual machine. For the Disk Capacity, enter the size that is recommended by VMware and then choose "Store virtual disk as a single file".
Select "Edit Virtual Machine Setting". On the Hardware tab, click on "Hard Disk (SATA) 40 GB" and then click on Remove.
On the same window, click on Add. For the disk type, select SATA. Click Next and select "Use an existing virtual disk".
Once it's created, click on the new hard disk and then click on the Disk file field. Browse and select the macOS Sierra image file that you downloaded and extracted in step 2 (macOS Sierra.vmdk).
For the RAM, you can select between 2.56GB to 4GB and for processors, it can be 2 to 4 cores.
Open the folder where you extracted the macOS Sierra image file. Right click on the VMX file, choose Open with, and select Notepad.
Go to the end of the file and on a new line, copy and paste this code: smc.version = "0"
Turn on the macOS Sierra virtual machine.
Click on CD/DVD, make sure that Device status is set to 'Connected' and 'Connected at power on'.
On the same window, under Connection, choose 'Use ISO image file', and then browse and select 'VM Tool.iso' from the files that you downloaded in step 1.
Congrats! You have successfully installed macOS Sierra 10.12 on Windows using VMware. You can now use macOS on your Windows machine and run any mac-specific program within the newly created virtual machine without having to own a Mac.
macos not showing on latest version of VMware when trying to create new virtual machine… do i need an older version of vmware?
I think you missed Step 3. The Patch Tool adds the Mac OS X option.
the VM is working but it doenst recodnise the iPhone when i connect it… how can i fix this?
Did you find the solution please share.
@riko_mukhlis:disqus @disqus_bSzEk4tMfg:disqus That's strange. Can you try with the new mirror link I added: Mirror Link 1. Or maybe you have an Anti-Virus software installed which is accidentally removing it.
You have to look in the "Location" folder on step 5. I had to watch a YouTube video to figure it out.
why my iphone was not connect with itunes on mac just connected with itunes on windows ???
Anyone else having mouse issues?
Same issue here. Does it need verbose mode or certain flag to run on certain devices? Admin help..
I can not pass the apple logo. Does it need verbose mode or certain flag to run on certain devices? Admin help..
It is running so slow in VM. Can I use the vmdk file to dual boot macos with windows?
i used the oracle VB, with SSD and 8gb ram. it must cater the speed. not smooth experience but tolerable.
i had that problem before when my lappy was using HDD and a 4gb ram. now I upgraded to SSD and 8gb, i manage to run the OS not smooth but tolerable. I checked the task manager, it will eat your ram up to approx to 7gb. so i guess u need to upgrade.
it certainly due to your laptop capacity i believe. i had the same problem before i upgraded my lappy. now i have SSD on my OS and 8gb ram. it will eat up approx to 7gb ram when running the virtualbox.
Why i don't files like unlocker folder and vmx and other files?


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text:
Robyn von Swank
19 Best Things to Do in L.A. This Week
LA Weekly November 30, 2017
Felled trees become art at the L.A. County Arboretum, the Museum of Failure arrives in L.A. from Sweden, Jordan Peele answers questions about his hit movie Get Out at the Hammer, and more fun stuff to do and see in L.A. this week.
Metro Art screens Ava DuVernay's 2008 movie, This Is the Life, at Union Station, the last in a series of documentaries about L.A. directed by women. In 1989, B. Hall and her son launched weekly open-mic nights at the Good Life Café and health-food market in South Central as a safe and creative alternative to gangster rap for up-and-coming MCs. The only rule? No profanity. The open-mic nights ended in 1995, and the café closed in 1999. In her debut film, the Oscar-nominated DuVernay (Selma, 13th, OWN's Queen Sugar) interviews the hosts, regulars, DJs, graffiti artists and noncommercial but influential freestyling rappers who were part of the scene, such as Jurassic 5, Freestyle Fellowship, Abstract Rude, Volume 10, Medusa and Figures of Speech, which included DuVernay. The event features an introduction by B. Hall. Union Station, 800 N. Alameda St., downtown; Fri., Dec. 1, 8-10 p.m.; free. unionstationla.com. —Siran Babayan
The devastating windstorm that whipped through the San Gabriel Valley in 2011 downed trees and caused power outages. The winds also destroyed 235 trees and harmed 1,000 more at the Los Angeles County Arboretum and Botanic Garden. The following year, the arboretum invited artists to turn the toppled trees into sculpture, furniture, bowls, games, jewelry and other one-of-a-kind of pieces for its exhibit "Forces of Nature." Since then, more trees on the property, including a 150-year-old Tasmanian blue gum, have been ravaged by drought and disease. For the arboretum's follow-up display, "Forces of Nature II," more than 100 artists once again transform the damaged trees into works of art. Los Angeles County Arboretum and Botanic Garden, 301 N. Baldwin Ave., Arcadia; opening reception with live and silent auctions, Fri., Dec. 1, 6 p.m.; $25; Sat.-Sun., Dec. 2-3, 10 a.m.-4 p.m.; Thu.-Fri., Dec. 7-8, 10 a.m.-2 p.m.; Sat.-Sun., Dec. 9-10, 10 a.m.-4 p.m.; $9, $6 seniors & students, $4 kids, free 5 and younger. (626) 821-3222, arboretum.org. —Siran Babayan
Noah Baumbach's The Meyerowitz Stories (New and Selected) is the latest, most mature variation on the writer-director's favorite theme: the sublime difficulty of family. (This he shares with his friend and frequent collaborator, Wes Anderson). Distributed by Netflix after a strictly limited theatrical run, the film returns to the big screen for a special engagement at the New Beverly. A scabrous and sometimes sentimental filial drama, it also doubles as an excuse for Baumbach — a preternaturally gifted wordsmith — to sharpen his verbal knives. New Beverly Cinema, 7165 Beverly Blvd., Fairfax; Fri., Dec. 1, 8 p.m. (through Dec. 7, times vary); $8. (323) 938-4038, thenewbev.com. —Nathaniel Bell
Never turned your dream into a million-dollar business? Cheer up. At the Museum of Failure, a touring, pop-up exhibit that first opened in Sweden this summer, success is overrated. Founded by Swedish clinical psychologist Dr. Samuel West, this shrine to lame ideas highlights more than 100 technological, medical and scientific products dating back to the 17th century that had a short shelf life. Items such as the Segway, Google Glass, BIC for Her pens, Harley-Davidson's Hot Road cologne, Colgate's beef lasagna frozen dinner, board game Trump: The Game and Coca-Cola Blak's coffee-infused soda, because apparently you can be too overcaffeinated. A+D Architecture and Design Museum, 900 E. Fourth St., downtown; thru Feb. 4; Wed., 2-6 p.m.; Thu. & Fri., 2-8 p.m.; Sat. & Sun., noon-7 p.m.; $7, $5 seniors & students, free children. (213) 346-0734, failuremuseum.com. —Siran Babayan
Comedians Jamie Loftus and Caitlin Durante examine the historical and ongoing problem of female stereotypes in movies in their comedy-meets–film criticism podcast, The Bechdel Cast. Each week for the past year, the two hosts have invited a guest to choose a popular title and analyze the female leads and other topics according to the Bechdel Test, a set of criteria created in 1985 by cartoonist Alison Bechdel. A piece of fiction passes the test if it features at least two women talking to each other about something other than a man. Past titles have included The Wizard of Oz, Butch Cassidy and the Sundance Kid, Groundhog Day, Coming to America, Dirty Dancing, Beetlejuice, Titanic, The Matrix and Clueless. Not surprisingly, less than 20 percent of their picks have met the required standards. For their first live taping in L.A., Loftus, Durante and Debra DiGiovanni will discuss that '80s high-rise, terrorist-killing action classic Die Hard. In case you don't remember, nearly all the female characters are hostages. Nerdmelt Showroom, 7522 Sunset Blvd., Hollywood; Sat., Dec. 2, 7-8:30 p.m.; $10. (323) 851-7223, nerdmeltla.com. —Siran Babayan
Havana-based Malpaso Dance Company's visit to the Music Center represents the rare dance event at the Getty's extensive Pacific Standard Time: LA/LA initiative; it's part of the Music Center's island-focused weekend of events dubbed "Cuba: Antes, Ahora/Then, Now." Cuba is known for its brilliant ballet dancers, and this contemporary company made its name blending that fabled ballet technique with modern dance and moves from Cuba's streets and clubs. Leading up to the Saturday dance performance are Thursday's artist conversations, Friday's Afro-Cuban dance and percussion workshop and the late-night Sleepless: The Music Center After-Hours, and Saturday's rumba dance party and jam session. Special activities geared toward high school students include a master class with choreographer Sonya Tayeh. Music Center, Dorothy Chandler Pavilion, 135 N. Grand Ave., downtown; Sat., Dec. 2, 2 & 7:30 p.m., $28-$87. musiccenter.org/cuba. —Ann Haskins
L.A.-based artist Patrick Martinez mines elements of pop culture, graffiti, hip-hop and the urban environment to focus on urgent social issues, both on a local and national level. These have included his series of colorful Pee-Chee folders adorned with scenes of police brutality and outrage, as well as corner store–style neon signs emblazoned with evocative rap lyrics or political phrases, one of which was purchased by Drake. It said: "Less Drake, More Tupac." For his first solo museum show in L.A., "America Is for Dreamers," Martinez will be exhibiting paintings that incorporate stucco, tile, ceramic and neon, as if layered sections of the L.A. streetscape were hung on the wall. Eschewing sanitized Hollywood domesticity for a more realistic vision of L.A. life, Martinez questions to whom the "American dream" is really available. Vincent Price Art Museum, 1301 Avenida Cesar Chavez, Monterey Park; Sat., Dec. 2, 5-7 p.m.; thru April 7; free. (323) 265-8841, vincentpriceartmuseum.org. —Matt Stromberg
A provocative, politically engaged satirist whose beat was the grindhouse circuit, Larry Cohen was equally comfortable working inside and outside the Hollywood system. King Cohen: The Wild World of Filmmaker Larry Cohen, Steve Mitchell's generous cinematic portrait, explores the director's career from the vantage of his fans and colleagues. The American Cinematheque will premiere the new documentary to West Coast audiences followed by two of the director's quintessential 1980s pictures: The Stuff, about a yogurt that kills, and Q: The Winged Serpent, about an Aztec deity that lives atop the Chrysler Building, picking off nude sunbathers at will. Cohen and Mitchell will appear for a discussion following the first feature. Egyptian Theatre, 6712 Hollywood Blvd., Hollywood; Sat., Dec. 2, 7:30 p.m.; $15. (323) 466-3456, americancinemathequecalendar.com. —Nathaniel Bell
There are a few ways to take the stress out of holiday shopping. You can say "fuck it" and buy everyone you know Amazon gift cards from the comfort of your underpants/own home. Or you can casually peruse groovy works by local artists while a surf-rock band plays Christmas music and you sip a mai tai. The Tonga Hut hosts Tiki Wonderland 12, a holiday market with a Polynesian twist. Artists including Clee Sobieski, Ron Monster, Eric October, Stilettoed Devil and loads more display their wares, while beachy cover band High Tide plays The Ventures' Christmas album. Durangos Tacos will be on hand serving classic Mexican fare. Way more fun than buying gift cards from bed. Tonga Hut Tiki Lounge, 12808 Victory Blvd., North Hollywood; Sun., Dec. 3, 2-10 p.m.; free. (818) 769-0708, tongahut.com. —Gwynedd Stuart
Why can't it be A John Waters Christmas every damn day of the year? The film director, screenwriter, artist and stand-up comedian hits the road with his staged monologue on everything he loves and finds most curious about the merriest and most bizarre aspects of the Yuletide season. Waters will tell you that, in fact, he loves Xmas and that there's nothing "ironic" about his consumerist's celebration of the best and the worst of it. He also shares personal stories and sage advice on how to get through the Christmas ordeal relatively unscathed and hopefully with a huge pile of presents. 21 and up. The Comedy Store, 8433 Sunset Blvd., West Hollywood; Sun., Dec. 3, 9 p.m.; $55-$125. (323) 650-6268, thecomedystore.com. —John Payne
At 86, former CBS Evening News anchor Dan Rather is enjoying an unlikely second act, thanks in part to his popularity on social media. Well, "enjoying" might not be the correct word. Rather, who recently founded the online news outlet News & Guts, frequently takes to Facebook to lament the state of politics and political discourse in the age of Trump and to offer doses of common sense at a time when it seems to be in short supply. In his new book, What Unites Us: Reflections on Patriotism — co-authored with fellow journalist Elliot Kirschner — Rather expands on those musings; subdivided sections titled Freedom, Community, Exploration, Responsibility and Character explore what it means to be American, particularly when it feels like those ideals are being shaken to their foundations. At An Evening With Dan Rather, the veteran newsman and much-needed voice of reason discusses What Unites Us. The Novo by Microsoft, 800 W. Olympic Blvd., downtown; Mon., Dec. 4, 8 p.m.; $47-$76. (213) 765-7000, thenovodtla.com. —Gwynedd Stuart
New music isn't a new thing in L.A. The Monday Evening Concerts series has been presenting adventurous contemporary music — that avant-garde spinoff of classical music that's more about exploring the physical, cerebral, spatial and temporal possibilities of experimental sounds than reviving schmaltzy waltzes from ancient centuries — since 1939. Back then, the salon was led by European exiles Igor Stravinsky and Arnold Schoenberg, and later it hosted the U.S. debut of Pierre Boulez. Artistic director Jonathan Hepfer instigates MEC's new season by welcoming shape-shifting Italian composer Pierluigi Billone, Ensemble Vocatrix, soprano Anna Hauf and NYC's Talea Ensemble for "Fossil Voices," a program that contrasts excerpts from Hildegard von Bingen's reverential 12th-century incantation Ordo Virtutum with the West Coast premiere of Billone's Face. Zipper Concert Hall, 200 S. Grand Ave., downtown; Mon., Dec. 4, 8 p.m.; $27. (213) 260-1632, mondayeveningconcerts.org. —Falling James
The long and distinguished career of Mexico's Arturo Ripstein is ripe for rediscovery. His classic Western Tiempo de Morir — made when the director was only 21 — was given a weeklong run at Laemmle's Ahrya Fine Arts before premiering on Blu-ray and DVD. Now, AMPAS has programmed an evening dedicated to one of Ripstein's finest films, Deep Crimson, as part of Pacific Standard Time: LA/LA, a series of screenings and conversations exploring the work of Latino and Latin American filmmakers over the last half-century. A true-crime saga told in elegant long takes, this pitch-black comedy displays the director's formidable poker face in full view of the sordidness of life. Ripstein and writer Paz Alicia Garcíadiego are scheduled to appear for a discussion following the screening. Samuel Goldwyn Theater, 8949 Wilshire Blvd., Beverly Hills; Mon., Dec. 4, 7:30 p.m.; $5. (310) 247-3000, oscars.org. —Nathaniel Bell
To most people he's Doogie Howser or Barney Stinson from How I Met Your Mother, but Tony-winning and Emmy-nominated actor Neil Patrick Harris is also a magic enthusiast, having served as president of the Academy of Magical Arts at the Magic Castle. Today, Harris introduces his new middle-grade novel, The Magic Misfits, the first in a series that includes illustrations by Lissy Marlin. The story centers on Carter Locke, an orphan boy and street magician raised by a thief uncle, who joins a band of other illusionists to fight the bad guys in a small New England town called Mineral Wells. Harris discusses his book with Lemony Snicket (pen name of Daniel Handler), whose Lemony Snicket's A Series of Unfortunate Events on Netflix stars Harris as the devious Count Olaf. Japanese American Cultural & Community Center, Aratani Theater, 244 S. San Pedro St., downtown; Tue., Dec. 5, 7 p.m.; $24, $32 with child. (213) 628-2725, jaccc.org. —Siran Babayan
Phantom Lady, one of the key works of film noir, plays as part of LACMA's Tuesday Matinees series. Apart from the densely shadowed camerawork courtesy of director Robert Siodmak and cinematographer Elwood Bredell, the film also features a fiendishly clever plot hatched by Cornell Woolrich (the Edgar Allan Poe of postwar pulp fiction), on whose novel it's based. A man is accused of killing his wife and his sole alibi is a mysterious lady he met in a saloon. But no one ever saw her. Or so they claim. That's only the opening act of this twisty B-movie treasure. LACMA, 5905 Wilshire Blvd., Mid-Wilshire; Tue., Dec. 5, 1 p.m.; $4. (323) 857-6000, lacma.org. —Nathaniel Bell
Point Blank's cubist style shows the creeping influence of European art-house technique — especially that of Alain Resnais — on 1960s American cinema. But its director, the English-born John Boorman, has a style and agenda all his own, marrying frigid violence and noir trappings with bright pop color. Based on a Donald E. Westlake (writing as Richard Stark) novel, the vaguely defined plot concerns a gangster (Lee Marvin) seeking vengeance against his betrayers in the San Francisco underworld. The material also formed the basis of Brian Helgeland's Payback, filmed three decades later. Laemmle's Ahrya will show it as part of its Anniversary Classics series, with co-star Angie Dickinson slated to appear for a post-screening Q&A. Laemmle Ahrya Fine Arts Theatre, 8556 Wilshire Blvd., Beverly Hills; Tue., Dec. 5, 7:30 p.m.; $15. (310) 478-3836, laemmle.com. —Nathaniel Bell
As George St. Geegland, half of the cantankerous aging duo from the sketch-turned–Broadway show Oh, Hello, John Mulaney has racked up loads of experience on how to best conduct himself during his golden years. For the time being, he is still young and adorable and funny, and he's rubbing it in on stages throughout the country on his current Kid Gorgeous tour. An SNL writer for six years before helming his own short-lived eponymous sitcom, Mulaney has retained a lot of good will in the comedy world despite his show being named a "worst of 2014" by Entertainment Weekly. Everyone's a critic, but not everyone can make a comedy comeback like Mulaney can. His five-night stand at the Orpheum is close to sold out. Orpheum Theatre, 842 S. Broadway, downtown; Wed., Dec. 6-Sun., Dec. 10, 7 p.m.; $25-$35. (877) 677-4386, laorpheum.com. —Gwynedd Stuart
Incisive and insightful, comedian Jen Kirkman has committed to joke Valhalla some of our finest comedic observations about relationships — and now Jen Kirkman's Sixth Annual Dysfunctional Christmas Show is your chance to see her and other comedians putting our holiday woes into perspective with stories and jokes about the terrors they've distilled from Christmases past. For those wishing for something, anything, to mitigate the psychic agony of all this naked truth, there'll also be candy, Christmas music and decorations, and proceeds donated to a charity like Cats Without Whiskers or some such. Hollywood Improv, 8162 Melrose Ave., Beverly Grove; Thu., Dec. 7, 8 p.m.; $20. (323) 651-2583, hollywood.improv.com. —David Cotner
When Jordan Peele's first film, Get Out, was released earlier this year, it garnered praise from critics and audiences alike, becoming both the first film from an African-American writer-director to gross more than $100 million as well as the highest-grossing debut from a writer-director based on an original screenplay. Part racial horror film, part social satire, the genre-bending thriller takes aim at systems of white supremacy that lie just under the surface of supposedly liberal America; the woke college student who takes her African-American boyfriend home to her parents, or her dad, who would have voted for Obama a third time if he had the chance. Although the Golden Globes categorized it as a comedy, Peele more accurately describes it as a documentary, presumably not because it depicts actual events but because it reflects reality. The Hammer Museum's screening of Get Out is part of its Contenders series, organized with MoMA, and featuring notable films from the past year; the screening will be followed by a not-to-be-missed Q&A with Peele himself. Hammer Museum, 10899 Wilshire Blvd., Westwood; Thu., Dec. 7, 7:30p.m.; $20, $10 Hammer members. (310) 443-7000, hammer.ucla.edu. —Matt Stromberg

redpajama_set_name: RedPajamaCommonCrawl


text:
Águilas de Mexicali est un club mexicain de baseball évoluant en Ligue mexicaine du Pacifique. Fondé en 1976, le club basé à Mexicali dispute ses matchs à domicile à l'Estadio Casas GEO, enceinte de  places assises inaugurée en octobre 1976.

Les Águilas comptent trois titres domestiques et un succès en Série des Caraïbes, en 1986.

Palmarès
Champion de la Ligue mexicaine du Pacifique (3) : 1986, 1989, 1999
Série des Caraïbes (1) : 1986

Histoire

Le club moderne des Águilas de Mexicali est fondé en 1976. Deux clubs portent ce même nom avant cette date : de 1948 à 1958, des Águilas de Mexicali évoluent dans diverses ligues mineures mexicaines ou américano-mexicaines. De même, en 1968 et 1969, des Águilas de Mexicali jouent en Liga Norte de Sonora.

Les Águilas remportent leur premier titre en 1986 et enlèvent dans la foulée la Série des Caraïbes sous la direction du manager Benjamin Reyes.

Notes et références

Liens externes
  Site officiel du club

Club de la Ligue mexicaine du Pacifique
Club sportif fondé en 1976
Sport à Mexicali

redpajama_set_name: RedPajamaWikipedia


Q: With starting a home-based vegan foods business, is it better to set up as sole proprietor or LLC?
A: I considered this question a few months ago when I started my own law firm. Sole proprietorship is so simple and inexpensive and thus, so appealing. But after researching the issue, I chose the LLC instead. While my law firm might not be as tasty a venture as your vegan foods business, the issues we face in choosing our business entity are the same.
The positive: There is no easier way to launch a business than as a sole proprietor -- basically, you just start working.
You ARE the business. Indeed, if you want to name the business something other than your legal name, you'll need to file a "Doing Business As," or DBA, name in the states in which you're engaging in business. But that's really all: It's simple and inexpensive. Even the taxes are easy: You pick up all the profits and losses of your business on your individual tax return, and you don't need to file a separate return for the business.
The negative: A sole proprietor has zero liability protection. So, if someone gets sick from one of your vegan goodies, they can sue you personally. If they win, they will have access to all of your assets: your money, home and cars, among other assets.
If you were selling scarves instead of food, a sole proprietorship might be for you. But any business with potential liability (that can't be sheltered with insurance) should not be a sole proprietorship.
The positive: The biggest benefit of the LLC over the sole proprietorship is that the LLC shelters you from liability. A potential plaintiff would have to sue the LLC -- and if he or she wins, the person would generally be limited to the assets of the LLC (not your personal assets). A single-member LLC is taxed in the same way as a sole proprietorship: The profits and losses flow through to your individual tax return. But, unlike a sole proprietorship, you can add one or more partners. While you give up the simplicity of filing your business's profits and losses on your own tax return at that point, the LLC still gives you the benefit of pass-through taxation.
The negative: An LLC is a statutory entity, which means that you'll need to file a certificate of formation (this document has different names in different states) and pay filing fees to set up the entity. This is a simple process: You can generally find the directions to file, along with a sample form, on a state web site. Or you can work with a filing company that will charge a fee to process the filing.
Once you decide to form an LLC, you need to determine which state will be your home base. Often this is an easy decision: It's where you're doing business. If, however, you intend to raise capital for your business, you should file the initial certificate of formation in Delaware, even if you're not based in Delaware. This is a more expensive process, because you'll end up paying a couple of hundred dollars extra each year for someone to act as your local representative, (address) and you will need to request authority to do business in the other states in which you engage in business, costing even more money. The added expense may be worth it as Delaware is the state of choice for most investors.
Often, you will hear that if you're seeking venture capital for your business, you should set up a corporation. While it's true that venture capital funds tend to only invest in corporations (unless venture capital is imminent) there is a potentially significant tax cost to you if you start out as a corporation: You'll lose out on all the losses from the start up phase that you can deduct on your personal return if you're an LLC. I always advise to start up as an LLC in Delaware where it is very simple to convert to a corporation right before the closing of a venture fundraise.


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Home Mining Pomerantz Law Firm Announces the Filing of a Class Action Against SOS...
Pomerantz Law Firm Announces the Filing of a Class Action Against SOS Limited and Certain Officers – SOS
NEW YORK, March 31, 2021 /PRNewswire/ — Pomerantz LLP announces that a class action lawsuit has been filed against SOS Limited ("SOS" or the "Company") (NYSE: SOS), and certain of its officers. The class action, filed in the United States ("U.S.") District Court for the District of New Jersey, and docketed under 21-cv-07454, is on behalf of a class consisting of all persons and entities other than Defendants that purchased or otherwise acquired SOS American depository shares ("ADSs") between July 22, 2020 and February 25, 2021, both dates inclusive (the "Class Period"), seeking to recover damages caused by Defendants' violations of the federal securities laws and to pursue remedies under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934 (the "Exchange Act") and Rule 10b-5 promulgated thereunder by the U.S. Securities and Exchange Commission ("SEC"), against the Company and certain of its top officials.
If you are a shareholder who purchased SOS ADSs during the Class Period, you have until May 31, 2021 to ask the Court to appoint you as Lead Plaintiff for the class. A copy of the Complaint can be obtained at www.pomerantzlaw.com. To discuss this action, contact Robert S. Willoughby at [email protected] or 888.476.6529 (or 888.4-POMLAW), toll-free, Ext. 7980. Those who inquire by e-mail are encouraged to include their mailing address, telephone number, and the number of shares purchased.
[Click here for information about joining the class action]
SOS is a technology company that purportedly provides marketing data, technology, and solutions for emergency rescue services. When the Company went public in April 2017, it was known as "China Rapid Finance Limited" and claimed to focus on a peer-to-peer, micro-lending business. The Company later changed its name to "SOS Limited" in July 2020 and sold its peer-to-peer, micro-lending business in August 2020, rebranding itself into an emergency services business. In January 2021, the Company again shifted its business focus, this time to cryptocurrency mining.
Critical to SOS's purportedly successful transition into a cryptocurrency mining business were the Company's claims to have entered into an agreement with HY International Group New York Inc. ("HY"), which calls itself the "world's largest mining machine matchmaker," to acquire 15,645 mining rigs—i.e., personal computing machines built specifically for cryptocurrency mining—for $20 million, and the Company's plans to purchase FXK Technology Corporation ("FXK"), a purported Canadian cryptocurrency technology firm.
In addition to rapidly changing its business focus, SOS has also rapidly changed the location of its headquarters. According to the Company's SEC filings, the address of the Company's principal executive offices has changed no less than five times since the Company went public in April 2017.
The complaint alleges that, throughout the Class Period, Defendants made materially false and misleading statements regarding the Company's business, operations, and compliance policies. Specifically, Defendants made false and/or misleading statements and/or failed to disclose that: (i) SOS had misrepresented the true nature, location, and/or existence of at least one of the principal executive offices listed in its SEC filings; (ii) HY and FXK were either undisclosed related parties and/or entities fabricated by the Company; (iii) the Company had misrepresented the type and/or existence of the mining rigs that it claimed to have purchased; and (iv) as a result, the Company's public statements were materially false and misleading at all relevant times.
On February 26, 2021, Hindenburg Research ("Hindenburg") and Culper Research ("Culper") released commentary on SOS, claiming that the Company was an intricate "pump and dump" scheme that used fake addresses and doctored photos of crypto mining rigs to create an illusion of success. The analysts noted, for example, that SOS's SEC filings listed a hotel room as the Company's headquarters. The analysts also questioned whether SOS had actually purchased mining rigs that it claimed to own, as the entity from which SOS purportedly bought the mining rigs appeared to be a fake shell company. The analysts further alleged that the photos SOS had published of their purported "mining rigs" were phony. Culper noted that photographs of SOS's "miners" did not depict the A10 Pro machines that the Company claimed to own and instead appeared to show different devices altogether. Hindenburg, for its part, found that the original images from SOS's website actually belonged to another company.
On this news, SOS's American depositary share ("ADS") price fell $1.27 per share, or 21.03%, to close at $4.77 per ADS on February 26, 2021.
After the end of the Class Period, between February 27 and March 3, 2021, Hindenburg subsequently provided additional information on SOS that further supported its earlier allegations, including pictures, highlighting, inter alia, how SOS had allegedly taken steps to hide the misconduct noted in the February 26, 2021 corrective disclosures.
The Pomerantz Firm, with offices in New York, Chicago, Los Angeles, and Paris is acknowledged as one of the premier firms in the areas of corporate, securities, and antitrust class litigation. Founded by the late Abraham L. Pomerantz, known as the dean of the class action bar, the Pomerantz Firm pioneered the field of securities class actions. Today, more than 80 years later, the Pomerantz Firm continues in the tradition he established, fighting for the rights of the victims of securities fraud, breaches of fiduciary duty, and corporate misconduct. The Firm has recovered numerous multimillion-dollar damages awards on behalf of class members. See www.pomerantzlaw.com
Robert S. Willoughby
Pomerantz LLP
SOURCE Pomerantz LLP
www.pomerantzlaw.com
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text:
Computer / Video Monitors
ATM Display Screen is optimized for sunlight readability.
DIsplay Concepts Inc. Jul 20, 2009
Offered as drop-in replacement for 10 in. CRTs and older 8.4 in. LCDs in NCR, Diebold, Fujitsu, and Wincor-Nixdorf ATMs, Palomar SunView V084H1 delivers full-color images that can be viewed in direct sunlight. LED backlight and ballast, combined with contrast level, promote readability while reducing power consumption. This 8.4 in. sunlight-viewable LCD monitor also supports built-in automatic dimmer in Diebold ATMs, automatically adjusting brightness according to ambient light.
Sunlight-Viewable ATM Display Screen Now has Lower Cost, Lower Power Consumption, Longer Life and Even Better Readability
Display Concepts redesigns its Palomar SunView 8.4" LCD monitor for NCR, Diebold, Fujitsu and Wincor-Nixdorf ATMs
Phelps, NY - July 6, 2009 - Display Concepts (www.display-concepts.com) has redesigned its 8.4" sunlight-viewable LCD to improve readability, reduce power consumption, increase the lifetime and reduce the cost of this unique high-brightness ATM display.
The model V084H1 high-brightness ATM monitor provides bright, full-color images that are easily viewable in direct sunlight. The improved design offers increased contrast for better readability. It also introduces support for the built-in automatic dimmer found in Diebold ATMs, automatically adjusting brightness in response to ambient lighting conditions to provide optimum viewing both night and day.
The improved model V084H1 is a redesign of the SunView ATM monitor line that Display Concepts acquired from Palomar Displays in 2007. A key upgrade was replacing the original fluorescent backlight with a new, more efficient LED backlight and ballast.
"Our engineering team has not only improved performance of the original SunView design, but has also created a product that is more environmentally friendly due to its lower power use and longer life," said Robert Rippberger of Display Concepts. "Field service personnel will also appreciate the lighter weight of the new LCD."
The V084H1 is fully backward compatible with the original Palomar SunView design and all bracket kits. It is a drop-in replacement for 10" CRTs and older 8.4" LCDs in NCR, Diebold, Fujitsu and Wincor-Nixdorf ATMs.
Display Concepts offers a full line of high-brightness and standard-brightness LCD screens for indoor and outdoor ATMs. The displays are designed and manufactured in western New York by Z-AXIS, the parent company of Display Concepts. Z-AXIS specializes in high-quality video display and electronic products engineered for long life in demanding applications.
List price for the V084H1 display is $749. It will begin shipping from stock in July.
About Display Concepts
Display Concepts has been providing high-quality replacement LCD monitors for automated teller machines (ATMs) since 2005. The copmany has a well-earned reputation for rapid turn-around and excellent customer service. In 2007 Display Concepts acquired the industry-leading SunView 2000 line of sunlight-viewable displays from Palomar Displays. In 2008 Display Concepts joined the VDC group of companies, where as a business unit of Z-AXIS, Inc. it is constantly improving its ATM screen designs and expanding its product line. Display Concepts ATM monitors are now designed and produced in Z-AXIS' modern 32,000 square foot design and manufacturing center in western New York. US-based design and manufacturing further supports Display Concepts' commitment to providing a high-quality product, fast turn-around and superior customer support. For more information visit www.display-concepts.com .
New ELITE XG320U Gaming Monitor Comes with PureXP 1ms (MPRT) Technology
24VDC-powered LCD Monitors offer brightness of 2,200 nits.
CRT Monitor is compatible with IBM PC systems.
SRMH-24R Monitor comes with Ambient Light Sensor.


text:
Weddingsthe ring findersmetal detecting
Lost Your Wedding Ring? These Strangers Will Find It For You
How did we not know about this?
Rebecca Shapiro
Senior Editor, HuffPost
Sep 14, 2016, 02:13 AM EDT
Todd Arbini via Getty Images
A gold ring lost in the sand.
If you've ever dived into the ocean and lost a beloved ring, you know the feeling of helplessness that inevitably follows. "It's gone," you whisper to yourself. "Forever."
Well, turns out that might not be the case.
In 25 countries around the world, there are metal-detecting professionals waiting for your frantic phone call. Connected through TheRingFinders.com, an online directory dedicated to helping people find jewelry that was lost outdoors, these specialists will search through beaches, parks, lakes and yards to reclaim your missing treasure.
Chris Turner, who founded the website, spent decades running his own metal detecting company in Vancouver, British Columbia. When he realized that the public could benefit from metal detecting services to locate lost jewelry, Turner set up the directory to connect people with professionals on six continents (for now, you're on your own if you lose something in Antarctica).
"Please keep in mind that this is a directory to help you find a metal detecting specialist to search for your lost jewelry, and not a referral service," Turner stated on his website. Specialists found through the site are independent operators and charge their own rates, though oftentimes they don't ask for payment, only reimbursement for travel expenses and a charitable donation, according to the BBC.
Reddit User unleafthekraken, who was on North Myrtle Beach in South Carolina when he lost his new wedding band, said the metal detecting specialist he used did not charge him.
"As a newlywed dummy, I went in the ocean with my wedding band on, and immediately got hit by a wave which pulled it right off," he posted on Reddit. "After calling and explaining my situation, he showed up in 15 minutes, and found my ring in less than an hour in about a foot of water off shore (the tide had gone out at this point)."
While some pieces are discovered fairly quickly, Turner told HuffPost that sometimes the search could take many hours or even days.
"Every ring has an amazing story attached to it. That story ends when the ring is lost. What we do is help continue that story by finding it for them," he said.
Over the years, metal detecting specialists have had some success recovering wedding bands. Richard Browne, who helps people find buried treasure in Cape Cod, said he's returned roughly 100 rings in his 30-year career.
Newlyweds, take note.
H/T Reddit
the ring findersmetal detecting
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The demand for new on-demand technology services and the cost of deploying and managing them continue to skyrocket. In order to manage deepening costs, complex deployments, and ensure reliability and uptime, data center managers need access to information and data that isn't always readily available. These are the top five challenges data center managers face and how a Data Center Infrastructure Management (DCIM) solution can address those challenges.
If you're using spreadsheets or homegrown tools to manage your server information, you probably already know the information stored can be outdated, inaccurate, or incomplete. This can prove challenging when unplanned downtime requires troubleshooting, or when attempting to map the power chain.
A DCIM solution provides a single repository to house your asset information. It enables consistent and accurate record keeping, and provides instantaneous visual and textual information to reduce the time it takes to locate assets and dependencies, thereby reducing troubleshooting time.
In a dynamic data center it is almost impossible to understand how much space, power, and cooling you have; predict when will you run out, which server is the best for a new services, and just how much power is needed to ensure uptime and availability.
Using a DCIM tool to quickly model and allocate space, manage power and network connectivity are key to discovering hidden capacity while better managing the capacity you do possess.
A DCIM solution with dashboard and reporting tools capable instantly aggregates data across several dimensions allowing data center managers to quickly show stakeholders that the data center is moving toward full operational efficiency.
A DCIM solution helps data center managers monitor energy consumption, cycle off servers during off hours, and identify candidates for consolidation. Environmental sensors can collect information for safely raising temperature set points. It can also help the company to implement an energy billback program that can drive energy efficient behavior.
Non-automated or manual systems require facilities and IT staff to spend an extraordinary amount of time logging activities into spreadsheets. This takes away time that can be spent making strategic decisions for the data center and improving service offerings.
DCIM solutions automate manual processes like workflow approvals and the assignment of technicians to make adds, moves, and changes. This also assists with provisioning and auditing, all while achieving operational savings.
Download our eBook, DCIM Demystified, to learn more about how Sunbird's DCIM can help you meet your data center challenges.


Enjoy a delicious two course lunch in the company of coach and founder of Alpha Challenger Fitness?and The Maryline Health Retreat, Alex Carter.
"When your body is functioning the way it is designed to function, you should be experiencing boundless energy all the time,?a keen awareness of your surroundings, a very strong and positive emotional state and a natural love and zest for life".
Alex believes with the support of meditation and working on mindset, once you understand the mind's relationship with the body, you can achieve your goals.
?5 from each person goes towards the local Wiltshire Bobby Van Trust.


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Tag: Barracks
27Oct By dthataNo Comments
Lekki: ASCAB Identified The Barracks Of Soldiers Who Shot Protesters – Falana
Femi Falana, human rights lawyer, says the Alliance on Surviving COVID-19 And Beyond (ASCAB) has identified the barracks of the soldiers who opened fire on protesters at Lekki toll gate in Lagos. On Tuesday, soldiers opened fire on the protesters who blocked the toll gate while demanding an end to police brutality. The issue sparked an outrage across the globe. Speaking when he featured on ARISE TV on Monday, Falana, who is chairman of ASCAB, said the group has been able to trace the barracks where the soldiers came from. "We have already identified the barracks where the soldiers left for Lekki, we have already identified the barracks," Falana said. "The President was likely to have been told, soldiers were ordered so I want to believe that's why it was not addressed and ...
Mali Coup: UN Security Council Orders Soldiers To Return To Barracks
United Nations Security Council on Wednesday ordered Malian mutineers to immediately release detained officials, including the country's president, and "return to their barracks without delay." The 15 members also "underlined the urgent need to restore rule of law and to move towards the return to constitutional order," according to a Council statement. Rebel soldiers took President Ibrahim Keita and Prime Minister Boubou Cisse into custody on Tuesday afternoon and drove the pair to a military base on the outskirts of Bamako, which they had seized that morning. Keita, whose government had been beset by months of protests over economic stagnation, corruption and a brutal Islamist insurgency that has claimed thousands of lives, later announced early Wednesday that he had resign...
Boko Haram Attacks Military Barracks in Borno
Boko Haram insurgents on Monday July 13, attacked 333 Artillery Barracks in Maiduguri, Borno state. The barracks said to be a short distance from the Nigerian Air Force base in the ancient city, was attacked by 11:20pm. TheCable reported that the insurgents had attacked some parts of the town before heading to the barracks which they surrounded. Tajudeen Umar, a Maiduguri resident told the publication that loud explosion roused him from sleep. He said; "We are under serious attack in this city. Sounds of gunshot and bombs from different direction. I can't tell precisely where this is from but the sounds are clear." Military sources who reportedly confirmed the attack, said soldiers responded immediately but the insurgents had already surrounded the barrac...
2Jun By BobbyNo Comments
Soldier Recounts how his Mother was Raped inside the Barracks by a Fellow Soldier
A former Nigerian soldier has shared the sad story of how his mother was raped by a neighbor in the barracks where he lived. Sharing his story via his Twitter handle @FestusNG, the former soldier said when he was still serving in 146 Batallion, his mum had come to pay him a visit in the barracks. He left for work and a neighbor, a fellow soldier, found his way into his house, stabbed his mum, and raped her. ''Rape is a disgusting thing. When I was a soldier serving in 146 battalion. My mum visited me, brought foodstuffs, cooked all sorts of food and served my neighbours (soldiers). At 6pm, I left for my duty. My neighbour broke into the ceiling and gained entry into my apartment. Stabbed my mum twice at the back and raped her. My mum was a mess and almost took her own life. I ...
Protest Reported Following the Death of Four Ibadan Residents by Customs Officers
About four people were, on Tuesday, allegedly killed by Customs officers in Ibadan, the Oyo State capital. Residents of the area gave two different narratives of the incident. While some said the victims were killed when a seized truck controlled by Customs officers hit road users, others said the victims were shot during a protest following the truck accident. WotzupNG gathered that the protest occurred opposite the NCS barracks in Ijokodo area of Ibadan. The barracks is located along the Ijokodo- Apete Road. Witnesses said chaos started when some Customs officers seized a trailer carrying prohibited items into the country. The officers after seizing the trailer were said to be driving it to their barracks. A witness said the trailer's brake failed and the driver lost c...
8Feb By BobbyNo Comments
Soldier goes on shooting rampage livestreamed on Facebook, Kills at least 17 People and Injures 21Others
A Thai soldier has killed at least 17 people leaving 21 others injured during a shooting rampage in the northeastern city of Nakhon Ratchasima. Police identified the suspect as Sergeant Major Jakrapanth Thomma, who is still at large. The Sergeant reportedly began his murderous rampage on Saturday afternoon at his barracks, where he executed his commanding officer along with two other soldiers, before stealing an army vehicle and posted photos and video of himself in full gear as he carried out the attack. Earlier in the day, he wrote on his Facebook page: "Death is inevitable for everyone." After stealing the army vehicle, he drove along the motorway toward the Terminal 21 shopping mall in Korat, a city 155 miles northeast of Bangkok, and opened fire on civilians along the ...
11Aug By BobbyNo Comments
Robbers invade police barracks in Delta
Police officers and their families residing in the 'B' Police Barracks along the Benin-Onitsha expressway in Asaba, Delta State have raised the alarm of incessant robbery attacks on them in recent times. The residents of the barracks who spoke to The Sun on condition of anonymity, said the robbery suspects have taken advantage of the prevailing dakrness in the barracks to unleash series of attacks on them. The barracks was thrown into darkness two months ago after yet-to-be-identified persons vandalized the transformer serving the barracks and who also made away with the cables. ''Robbers have been coming here to dispossess us of our property. We have lost power generating sets, handsets laptops and personal effects to the dreaded thieves. There is uncleared vegetat...
Algeria Military Plane Crash Kills Two People
A military plane crash has killed two people in Algeria, the fighter jet crashed during an overnight training exercise, killing its crew members. According to the defence ministry, the Russian-made Sukhoi SU-24 plane went down in an uninhabited farming area in the province of Tiaret, around 250 kilometres (155 miles) southwest of Algiers. The pilot and co-pilot were killed during the "night-time training flight", it said, adding that it was investigating the causes of the accident. It was the first such incident since the country's worst military plane crash that killed 257 people in April last year at a military base near Algiers. In April an Ilyushin IL-76 transport plane slammed into a field near an airbase south of Algiers, killing 257 people — Algeria's deadliest such ...
3 Dead With Several Cars Burned As Tanker Fell And Went Up in Flames At Ojo Barracks
At least 3 people have died and several cars were burnt after a tanker fell and exploded at Ojo Barracks, along the Lagos - Badagry express road. According to reports, the accident happened in the wee hours of this morning, at about 3 am, and despite the heavy rain that fell, the tanker was still on fire at the time of publishing this report. An eyewitness who spoke to LIB claims that more than 3 people died in the tanker explosion. A container carrying generators was also caught in the fire. Cars with businessmen's goods were burnt together with the contents. Car carrying cartons of fish Occupants of the cars plying that route who tried to escape the fire fell into the rain water, already made hot by the fire, and they were scalded to death. The eyewitness s...
2Oct By BobbyNo Comments
Horror: Many Cars Razed As Fuel Tanker Explodes At Night At Ojo Barracks In Lagos (Video)
Many cars have been reportedly razed at Ojo barracks in Lagos state after a fuel tanker fell and exploded in the area. The scene of the accident A serious fuel tanker explosion has been reported in Lagos Badagry Expressway on Tuesday morning. Casualty has not been ascertained, but unconfirmed reports say four tankers were involved in the accident and many commercial buses were up in flames. Many Nigerians have taken to twitter to report the incident which is said to have occurred at 5.32 am at Barracks bus stop in Ojo. According to Jose  @yemmytimmydar, "A big bang of tanker explosion at Barracks now 5:32am'' GIDITRAFFIC Verified account @Gidi_Traffic which retweeted"@olaabdulakeem: " Tanker explosion at Barracks Bustop along Lagos Badagry Exp way this early...
2Sep By BobbyNo Comments
Edo Community Calls For Military Presence
BENIN—THE people of Akoko-Edo Local Government Area of Edo State have called on the Federal Government to establish a military base in the locality to complement the state government's efforts in stemming the alarming rate of kidnapping and other violent crimes in the area. Members of the Nigerian Armed Forces Sniper Unit stand in their ghillie suits at the African Land Forces Summit (ALFS) military demonstration held at General Ao Azazi barracks in Gwagwalada on April 17, 2018. The African Land Forces Summit (ALFS) is a weeklong seminar held in Nigeria, bringing together land forces from across Africa to discuss and develop cooperative solutions and improve transregional security and stability. / AFP PHOTO / The call is came after kidnap of the All Progressives Congress, APC,...
28Aug By Czar Owolabi MarcusNo Comments
Benue Residents Count Losses After Four-Hour Downpour
Many houses in the Makurdi metropolis were in the early hour of Sunday submerged following a four-hour downpour. The rain, which started around 11.56 pm on Saturday and lasted till 4.08am Sunday morning, rendered many people homeless. The devastating effect of the flood was recorded in the following areas: Zone 4, Atusa, Nyiman, and some areas of Wadatta, Gana, all in Makurdi, the capital of Benue State. A resident of Nyiman and a mother of two, Ms Jane Iorhember, said that the surging water woke her up around 2.30am to discover that the area had been flooded. She said, 'I did not know the actual time the rain started but I woke up when felt something cold in my body only to discover that the mattress was already soaked, this was around 2.30am. "At this time, there was no li...
13Jul By Czar Owolabi Marcus1 Comment
Confusion As Bullet Allegedly Fired From Military Barracks Hits Pupil During Exams
A private nursery and primary school in the Ajobo area of Ibadan stopped its third term examination after a bullet allegedly fired from the 2 Division, Nigerian Army, Adekunle Fajuyi Cantonment, Ibadan, Oyo State, hits a nursery one pupil in the classroom. It was gathered that parents quickly rushed to the school after the incident happened to take their children home. An employee of the school, who spoke on condition of anonymity, said the pupil was sitting for the examination when the bullet pierced through the roof and hit him on the head. He said the victim was rushed to a nearby military hospital. He said, "Expended bullets were picked on the school premises; they came in through the roof. This is the first time such an incident would be recorded since the school began operat...
20Jun By Czar Owolabi Marcus3 Comments
Army, Dangote Re-Construct Barracks Destroyed During Ikeja Bomb Blast
The families of some troops who were displaced from their barrack during the 2002 bomb blast can heave a sigh of relief following the construction of a portion of the barracks by the 9 Brigade of the Nigerian Army and Dangote Foundation. Speaking at the commissioning of the of the nine blocks of eight flats each, at the Alasia quarters of 9 brigade, the Chief of Army Staff, Lt Gen. Tukur Buratai, stated that the request to seek the assistance of well meaning corporate organizations to improve the welfare of troops, particularly at the Ikeja cantonment became necessary , as the requirement was enormous for both the Federal government and the Nigerian army to handle alone. He expressed gratitude to Dangote Group for yielding to the demand when approached, by completing the constructio...
10Jun By Czar Owolabi MarcusNo Comments
138 Soldiers Benefit From Buratai's Accommodation Project In Calabar
The Chief of Army Staff, Lt.-Gen. Tukur Buratai, said 138 soldiers from the 13 Brigade Nigeria Army Calabar and their families have so far benefited from the Chief of Army Staff Accommodation Intervention Project. Buratai stated this on Saturday in Calabar while inaugurating the second and third phases of the project, which comprises of 49 single and 52 one -bedroom flats respectively. The News Agency of Nigeria reports that the COAS was represented at the occasion by Maj.-Gen. Christopher Jemitola, Chief of Policy and Plans, Army Headquarters, Abuja. Buratai said that the project was aimed at phasing out shanties from Army barracks across the country. The COAS had earlier on Feb. 26, inaugurated the first phase of the building, which comprised of 37 flats, at the Akim Barracks...
We Will Resist Any Coup- Tinubu
National Leader of the All Progressives Congress (APC), Asiwaju Bola Tinubu The national leader of the All Progressives Congress (APC), Asiwaju Bola Ahmed Tinubu, Monday, said that Lagosians will resist any coup plots, as it would not provide fertile ground for any undemocratic actions. Speaking at a special parliamentary session to celebrate Lagos at 50 at the Lagos State House of Assembly, Tinubu, who noted that Nigeria has gone too far democratically to allow anti-democratic forces into its governance process, said that those enticing the military to come out of the barracks wanted to undermine the present democratic process. According to him, the coup plotters "will not get ready buyers for their product," because a lot of people sustained injuries and sacrificed their lives f...
26Apr By Czar Owolabi MarcusNo Comments
Mercenaries From Offiong In Cross River Murder Many In Oku Iboku, Akwa Ibom
According to an online user who shared these disturbing photos,the victims pictured below were murdered in Oku Iboku, Akwa Ibom State by mercenaries from Ikot Offiong in Cross Rivers State. He called on Federal government to either establish military barracks in the area or do the needful.
Alexander Gall Acquitted Of Seven Charges Over 2012 Crash That Killed Jordan Penpraze
A SOLDIER charged over a fatal troop carrier crash at a Sydney army barracks has been found not guilty of all seven charges. Alexander Gall, 24, was charged over the 2012 crash of the Mercedes-Benz Unimog at Holsworthy Barracks four years ago, which killed 22-year-old Sapper Jordan Penpraze and injured six others. There were gasps and cries from the public gallery in the Downing Centre District Court on Thursday as Gall was cleared. Outside court Gall fought back tears as he apologised to the Penpraze family for the pain and loss he caused. "Not a day has gone by where I do not wish that I could have those moments back so that they could have their son back," he told reporters on Thursday. "I'm so deeply sorry to all those passengers and anyone else involved." When he gave evidence a...
Lagos Police Commissioner Orders Evacuation of Residents From Ikeja Barracks After Collapsed Building Killed 2
Residents of two other residential blocks at the Lagos Police barracks, Ikeja, have been ordered to quit the buildings. The Lagos State Commissioner of Police, Fatai Owoseni, gave the order while monitoring the demolition of a collapsed building in the barracks. The other two blocks to be vacated, located adjacent the collapsed W block building, are blocks V and U. Tragedy struck in the early hours of Sunday when the toilets and stairway of wing D of the block collapsed at about 4.00 a.m. The Lagos State Emergency Management Authority, LASEMA, said that bodies of two dead men were recovered after the incident. The victims were identified as one Mr. Danjuma, a police officer, and another male relative of Mr. Danjuma, whose identity is yet to be confirmed. Their bodies have since be depo...
Nigerian Soldier Beaten To Pulp In Warri
An unidentified soldier was on Monday beaten to pulp for allegedly stealing an iphone belonging to a young lady on gun point, yesterday. DAILY POST gathered that the lady raised alarm at the popular Robson G. Shopping plaza, along Okumagba Avenue in Warri after recognizing the soldier.  Sensing danger, the soldier, who was putting on military camourflage tried to escape from the scene with a knife in his hand. However, the angry mob gave him a hot chase out of the plaza to Erhiovo and Ogbodu streets near, Olodi Primary School, where they gave him the beating of his life, with his inner wears stained with blood. It took the intervention of mobile policemen on guard at the shopping plaza to save him from the hands of the angry mob.The mobile policemen escorted him to the reside...


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Coronavirus Emergency Appeal
6,000 Children Could Die Every Day Because of COVID-19
Children are at risk of becoming the hidden victims of COVID-19 because whilst they won't die from it they will die because of it.
In fact, 6,000 more children could die every single day as a direct result of the coronavirus pandemic. That's one child every 15 seconds.
The coronavirus (COVID-19) pandemic has upended the lives of children and their families around the world. Health systems have buckled, borders have closed, supply chains are cut-off, schools are shut and businesses have closed.
Without basic hygiene supplies, clean water, food and medicine, children will struggle to survive.
Confirmed cases in Syria and Yemen, countries which have been ravaged by conflict, are deeply concerning. With limited healthcare systems, and a population who have already suffered from malnutrition, cholera and other diseases, they will struggle to fight this virus. The impact on children, from both the disease and its terrible consequences, will be catastrophic.
That is why we must act immediately to give children, and their families, access to clean water, sanitation, life-saving food and medicine so they can protect themselves during this dangerous time.
With cases rising every day and more than 180 countries affected we urgently need your support to tackle the spread and help protect vulnerable children.
Direct Consequences of COVID-19
More children will die for lack of food
With countries in lockdown and movement hampered, vital aid like food won't get to those who need it most. In Yemen alone, over 12 million children are already in need of humanitarian assistance, with 360,000 children severely malnourished.
More children will die for lack of medical help
It's estimated that in the worst affected countries, the pandemic could lead to almost half of all health services being closed.
Yemen's health system is already on the brink of collapse and outbreaks of dengue fever, acute diarrhoea and cholera are all real and regular threats to children's lives. As the pandemic wreaks its havoc, families will find it impossible to get their children to any kind of help at all.
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As the virus reaches refugee camps inside Syria and along its borders in Jordan and Lebanon, the overcrowded and insanitary conditions will make it next to impossible to halt. Parents and grandparents will get sick and many children will be left with no one.
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Baby Jana is assessed for malnutrition using a MUAC band at a UNICEF supported health center in Aleppo Syria.
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At almost eight months old, baby Ali is no match for COVID-19. He's so sick he's in the hospital in Yemen's capital Sana'a.
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In this course, students create the Spirit Yearbook under the guidance of editors and an adviser. Students who take this year-long course will continue to develop Journalistic writing skills, as well as learn design and photographic composition skills. Students are expected to edit copy and design. Students will work with each other to develop layouts and create and gather all elements necessary for spreads; photographs, captions, graphics, copy and ethics consistent with responsible journalism. This course is not only a class, but a club and requires after school work to complete the tasks assigned. An application and teacher recommendation is required for all students enrolled in this course. This course may count as a Practical Art credit.


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text:
to the homepage of the Ducho group! This website provides you with infos on the group members and our research activities in Pharmaceutical and Medicinal Chemistry.
Our review on the cellular targeting of oligonucleotides with small molecules has been published in Molecules as part of the Special Issue in honor of Piet Herdewijn (DOI: 10.3390/molecules25245963).
Our paper on hybrid structures of muraymycin and sansanmycin nucleoside antibiotics has been published in Chem. Eur. J. (DOI: 10.1002/chem.202003387).
Our paper on zwitterionic NAA/LNA-gapmer oligonucleotides with improved properties has been published in ChemBioChem (DOI: 10.1002/cbic.202000450).
A paper from our collaboration with the group of Steven Van Lanen and others on nucleoside antibiotics biosynthesis has been published in Nat. Chem. Biol. (DOI: 10.1038/s41589-020-0548-3).
Our paper on unexpected seven-membered ring formation for muraymycin antibiotics has been published in Molbank as part of the Special Issue "Molecules from Side Reactions" (DOI: 10.3390/M1122).
Another paper from our collaboration with the group of Bilha Fischer on oligonucleotide probes for the detection of a breast cancer marker has been published in Bioconjugate Chem. (DOI: 10.1021/acs.bioconjchem.0c00130).
Link to News Archive
Full Professor of Pharmaceutical and Medicinal Chemistry


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Bypoll Results: Strong CMs Win, Lessons for BJP & Cong. What's the Big Picture?
Except for the sweep in Assam, it was a poor result for the BJP, especially in HP, West Bengal, and Rajasthan.
Aditya Menon
Updated: 03 Nov 2021, 12:56 PM IST
The by-elections to the 29 Assembly and three Lok Sabha seats have not thrown up any major national-level trend.
It may not be correct to look for any big national trend because the incumbent party at the state level tends to have an advantage in bypolls, based on data from past elections analysed by The Quint.
However, in the current bypolls, a few broad trends have emerged.
Strong regional leaders across the party lines have come out on top – from West Bengal Chief Minister (CM) Mamata Banerjee of the All India Trinamool Congress (AITMC), to Bharatiya Janata Party (BJP)'s CM in Assam Himanta Biswa Sarma, Rajasthan CM Ashok Gehlot of the Congress, Shiv Sena supremo and Maharashtra CM Uddhav Thackeray, Indian National Lok Dal leader Abhay Chautala, Meghalaya CM Conrad Sangma and Andhra Pradesh CM YS Jagan Mohan Reddy.
According to psephologist and CVoter founder Yashwant Deshmukh, "Incumbent governments did everywhere well except in two states: Telangana and Himachal Pradesh. In both the states, there is a great deal of anger against the state government."
Coming to the two national parties, purely in terms of seats, the BJP's overall tally came down by one in the Lok Sabha while it gained three Assembly seats overall. The Congress' Lok Sabha tally increased by one and Assembly numbers fell by three.
However, the Congress may come out slightly happier than the BJP.
Except for Assam and to some extent Madhya Pradesh, it was a bad result day for the BJP as it suffered major reversals in Himachal Pradesh, West Bengal, and Rajasthan.
For the Congress, the results have been a mixed bag – good news from Himachal Pradesh, Rajasthan, and Maharashtra but disappointment in Assam, Bihar, and Meghalaya.
Let's look at the results of some of the states in detail.
West Bengal: Massive TMC Sweep, BJP Loses Deposits
The TMC won all four seats – Dinhata, Santipur, Khardaha and Gosaba – with massive margins. The average vote share of the party in the four seats was over 75 percent. The BJP could save its deposit in only Santipur while also losing two of the seats it had won in the Assembly polls – Dinhata and Santipur.
In Dinhata, which was vacated by central minister Nisith Pramanik, the BJP lost with an embarrassingly huge margin of 1.64 lakh votes. The party suffered a major defeat even in Pramanik's own booth.
The Communist Party of India (Marxist) (CPI-M) may draw some solace from its performance in Santipur and Khardaha as it was only marginally behind the BJP in terms of vote share. In the Assembly elections earlier in 2021, CPI-M had left Santipur for the Congress which could secure just 4.4 percent votes.
But CPI-M saved its deposit in the bypoll with a little under 20 percent votes, indicating that it managed to win back some of the votes it had lost to the BJP in the Assembly polls. Whether this helps the CPI-M recapture its base in other parts of the state remains to be seen.
Assam: BJP Sweeps, Raijor Dal Displaces Congress in Upper Assam
The results are a big win for the ruling National Democratic Alliance (NDA) government in the state as the BJP and its ally United People's Party Liberal (UPPL) swept all five seats that voted in the bypolls.
It is personally a victory for CM Himanta Biswa Sarma as three of the seats were won by candidates who defected from the Opposition Congress and the All India United Democratic Front (AIUDF) after the elections. Sarma is said to have played a key role in these defections.
The Congress had already fared badly in Upper Assam but now it has lost two more seats in the region – Mariani and Thowra – with its MLAs Rupjyoti Kurmi and Sushanta Burgohain winning after defecting to the BJP.
What's even more worrying for the Congress is that in both the seats, Akhil Gogoi's Raijor Dal has emerged as an important player. In Thowra, the party's candidate Dhairjya Konwar, a prominent activist, secured 27 percent of the votes, well ahead of the Congress candidate who lost his deposit.
In Mariani, Raijor Dal's Sanjib Gogoi got 17 percent votes, just marginally behind the Congress.
The Raijor Dal may be buoyed at the results and try to emerge as the main Opposition force in Upper Assam.
The only good news for the Congress is that it made gains in terms of vote share in Bhabanipur, which was earlier held by the AIUDF, whose MLA Phanidhar Talukdar won the bypoll after defecting to the BJP.
The results would also strengthen the hold of the UPPL in the Bodoland region as it retained Tamulpur and wrested Gossaigaon from the Bodoland People's Front (BPF).
This too is indirectly a win for Sarma as he was instrumental in the BJP's decision to dump the BPF and ally with the UPPL in the Bodoland region.
Rajasthan: BJP Fails To Come Even Second in Either Seat
The results from the by-elections have come as a major win for the Congress government led by Ashok Gehlot in Rajasthan.
The Congress has won both the seats – Dhariawad in Pratapgarh district and Vallabh Nagar in Udaipur district – with comfortable margins.
The BJP's performance has been disastrous as the party was pushed to fourth position in Vallabh Nagar and third in Dhariawad.
While Congress' Preeti Gajendra Singh Shaktawat won the seat, the BJP fell behind not just the Congress but also Udailal Dangi of Hanuman Beniwal's Rashtriya Loktantrik Party and Randhir Singh Bhinder of Janta Sena Rajasthan.
The BJP also suffered due to some infighting with the party rejecting former CM Vasundhara Raje's proposal to induct Bhinder. Raje may have been vindicated in the end.
The Congress also wrested tribal-dominated Dhariawad from the BJP, which was pushed to third position behind the Congress and an Independent candidate Thawarchand Damor. Thawarchand's case itself is interesting as he is a local tribal activist propped up by individual community members to bring their grievances into the political discourse.
The wins would strengthen Gehlot's position in the Assembly as well as from any possible rebellions within the Congress.
Madhya Pradesh: Tough Fight Between BJP and Congress
Three Assembly and one Lok Sabha seats voted in the bypolls in Madhya Pradesh. While the BJP won the Khandwa Lok Sabha seat and the Jobat and Prithvipur Assembly seats, the Congress was ahead in Raigaon. Except Khandwa, the parties ended up losing the seats that they had held, indicating some seat-level dissatisfaction.
The big picture from the state, however, is that while CM Shivraj Singh Chouhan is still strong, the Congress is very much in the competition in the state. The party's vote share was about 45 percent, less than two percent behind the BJP.
If this trend continues, it could make the state a close contest in the next Assembly elections two years from now.
Dadra and Nagar Haveli: Late MP's Wife Wins on Shiv Sena Ticket
The election to the Lok Sabha seat in the Union territory of Dadra and Nagar Haveli was one of the most fascinating contests in the bypolls. The seat had fallen vacant due to the demise of Independent MP Mohan Delkar, who had died by suicide earlier this year.
Before his death, he had made a number of allegations against the BJP government at the Centre, especially current Lakshadweep administrator Praful Khoda Patel who was earlier governing Dadra and Nagar Haveli.
The elections, in many ways, were centred around Delkar's allegations against the BJP. The late MP's wife Kalaben Delkar contested on a Shiv Sena ticket and defeated the BJP candidate with a sizeable margin.
Given the allegations by Delkar, the win is a political defeat for the BJP in the Union territory.
The result is a significant one in another way as it is the first Lok Sabha victory for the Shiv Sena outside Maharashtra.
With this, the party's tally in the Lok Sabha has gone up to 19.
Himachal Pradesh: Major Win for Congress
The biggest win for the Congress has come from Himachal Pradesh, where the party has won one Lok Sabha seat and three Assembly seats.
Pratibha Singh, wife of former CM Virbhadra Singh, won from the Mandi Lok Sabha seat. The Congress also did well in the Assembly segment of current BJP CM Jairam Thakur that falls in the Mandi Lok Sabha constituency.
This win is significant for the Congress as it takes the party's tally in the Lok Sabha up to 53. Pratibha Singh will also now be the party's only MP in North India outside of Punjab and Sonia Gandhi in Rae Bareli.
The party also retained the Arki and Fatehpur Assembly seats while wresting Jubbal from the BJP.
Price rise had become a major factor in the Himachal Pradesh election and this contributed to the BJP's defeat. CM Jairam Thakur also blamed price rise for the party's defeat.
The results bode well for the Congress with HP going to polls in a year from now. The party would now be fancying its chances of capturing the state from the BJP, especially given how HP has been voting out incumbents for the past three decades.
The BJP's defeat has now triggered speculation on whether the party would now replace CM Jairam Thakur, the way it changed CMs in Gujarat, Karnataka, and Uttarakhand.
Karnataka: One Each for Congress and BJP
The results were a mixed for the BJP and the Congress, who won a seat each – BJP winning Sindgi in Vijayapura district and Congress wresting Hangal in Haveri from the BJP. Sindgi had earlier been won by the Janata Dal (Secular) (JD-S), which performed abysmally in both seats, getting less than 5 percent of the votes.
The Congress' win in Hangal is significant as it is part of Haveri, the home district of CM Basavaraj Bommai, who represents the Shiggaon seat.
The win strengthens Congress as the main Opposition in the state and would give momentum to it in the run-up to the Assembly elections around 18 months from now.
The JD(S)' loss in Sindgi and low vote share in both the seats may compel the party to think differently and try and go for an alliance with either the Congress or the BJP.
Meghalaya: NPP Gains at Congress' Expense
The results in the three Assembly seats in Meghalaya are a boost to CM Conrad Sangma whose National People's Party (NPP) won the Meghalaya Mawryngkneng and Rajabala seats, increasing its tally in the Assembly.
Both the seats were held by the Congress and the defeats would come as a blow to the party which is battling faction rivalries between leaders like Vincent Pala and Mukul Sangma.
The party had just managed to prevent Mukul Sangma from leaving and joining the TMC. But now the defeats in Meghalaya and Assam may be used by the TMC to create the impression of a "Congress decline in the Northeast" in order to woo disgruntled elements from the party.
Elections in Meghalaya are due in early 2023.
Haryana: Chautala Wins but BJP Holds Its Ground
Haryana also witnessed a crucial bypoll to the Ellenabad Assembly constituency in Haryana's Sirsa district. The seat fell vacant after the Indian National Lok Dal (INLD)'s Abhay Chautala resigned in protest against the central government's farm laws.
Though Chautala managed to win the seat, the result may give the BJP a reason to be happy. The party notched up a healthy vote share of almost 40 percent, giving Chautala a run for his money.
This despite the fact that the BJP is facing massive protests in the state due to the farm laws.
It does appear that the anti-farm law protests are dominated by Jats, who weren't with the BJP at the state level any way. On the other hand, the party has retained its base among non-Jat voters.
Chautala's win is also important because it means that the INLD will continue to get a chunk of Jat votes and the Congress won't be able to count on a complete consolidation.
The Congress got less than 15 percent vote in Ellenabad.
A consolidated non-Jat vote and divided Jat vote is good news for the BJP even with the defeat.
Read and Breaking News at the Quint, browse for more from news and politics
Topics: Bye-elections Rajasthan Bypolls West Bengal Bypolls
Published: 02 Nov 2021, 6:29 PM IST


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March 2, 2022 by racetab
F. (3). (iii) If the authors designed to cite the Levin et al. JID 2008 guide, we usually do not believe that it is easy for the authors to summarize from that publication which the immune response assessed by gpELISA [glycoprotein enzyme-linked immunosorbent assay], with regards to postvaccination geometric mean titer (GMT) as well as the geometric mean rise (GMR) in the VZV [varicella-zoster pathogen] antibody titer through the baseline to the time postvaccination, correlated greatest with security against HZ. The info pertinent to the concern in the JID 2008 content (3) is within Desk 3, which lists many correlations between immune system responses as well as the incident of HZ in the top pivotal trial of the HZ vaccine. The info provided for the reason that table usually do not recognize VZV-specific antibody as the very best correlate for immunity postvaccination, as well as the JID 2008 paper obviously states a surrogate marker of threshold for immunity had not been determined. Furthermore, data on the partnership of GMR to HZ, described by Gilderman et DL-AP3 al., aren't provided within this paper. We think that these corrections are essential as the Gilderman et al. content concluded that both zoster vaccine formulations examined DL-AP3 were equivalent in immunogenicity (and by implication in scientific efficacy) solely based on gpELISA outcomes, whereas there is certainly solid scientific proof that VZV cell-mediated immunity (CMI) is essential and enough for preventing herpes zoster, and immunologic assessments in a number of studies, like the Levin et al. JID 2008 content, document that degrees of antibody to VZV (e.g., assessed by gpELISA) aren't correlated with degrees of DL-AP3 VZV CMI (3). Authors' Reply Larry I. GildermanUniversity Clinical Analysis= 691) = 704) (95% CI)(95% CI)
GMTDeveloped HZ9271.9 (161.9-456.7)23181.6 (133.5-246.9)Didn't develop HZ658478.4 (444.6-514.7)661296.2 (273.3-321.1)GMRDeveloped HZ91.1 (0.9-1.4)230.9 (0.8-1.1)Didn't develop HZ6461.7 (1.6-1.8)6501.0 (1.0-1.0) Open up in a different home window GMR or aGMT, relative to the indicated endpoint. Cox regression evaluation confirmed that at 6 weeks postvaccination, both GMT (3) and GMR from baseline (data on document), as assessed by gpELISA, correlated well with security from HZ. Defense replies to vaccination by both VZV-specific gamma interferon enzyme-linked immunospot assay and gpELISA have already been shown to boost on the inhabitants level (2, 5), with much less assay variability in gpELISA. Nevertheless, these analyses had been limited by little amounts of data factors in HZ situations, which isn't unexpected within a vaccine trial, where immunogenicity data among situations pursuing vaccination are limited. We trust Levin that there surely is ample proof that VZV CMI is essential for avoidance of HZ. The relationship between VZV antibody titer as dependant on gpELISA and efficiency is presumed to become because of the fact that gpELISA procedures T-cell-dependent antibody replies (i.e., Compact disc4+ storage T cells activated by vaccination, triggering B-cell antibody creation, furthermore to growing the pool of turned on T cells). As a result, gpELISA may reveal a downstream way of measuring the CMI response to Zostavax. We agree, obviously, that VZV antibody will not appear to have got a direct function in DL-AP3 avoidance of HZ, and even though antibody may not be defensive, titers could be predictive even now. Antibody can also be a surrogate to get a different effector response (i.e., something apart from T-cell enlargement) that protects against HZ. Extra investigations to progress knowledge of VZV storage T-cell, effector T-cell, and antibody security and replies against HZ will be welcomed. We also concur that a surrogate marker of a particular threshold for security against HZ had not been determined in the SPS CMI substudy. Pivotal vaccine efficacy studies never have confirmed such surrogate markers of vaccine protection DL-AP3 often. Nevertheless, when surrogacy is certainly lacking, correlates of security may serve seeing that the building blocks for subsequent immunogenicity research. For scientific studies evaluating the comparability of vaccine formulations, concomitant administration with various other vaccines, and make use of using subgroup populations, gpELISA can be an appropriate and attractive assay for dimension of Zostavax response. There's a solid Rabbit Polyclonal to EDNRA relationship with vaccine efficiency against HZ; this assay is sensible for use in a number of scientific trial configurations (tests performed on serum rather than peripheral bloodstream mononuclear cells), as well as the magnitude of postvaccination response, coupled with low assay variability, permits discrimination of replies between research populations with a higher degree of self-confidence, regardless of the known fact that populations possess high baseline titers (1-4). Therefore, we the stand by position the relevance and utility of gpELISA as reported inside our article. Many thanks once for your time and effort and consideration again. Sources 1. Kerzner, B., A. V. Murray, E. Cheng, R. Ifle, P. R. Harvey, M. Tomlinson, J. L. Barben, K. Rarrick, J. E. Stek, M. O. Chung, F. P. Sch?del, W. W. B. Wang, J. Xu, I. S. F. Chan, J. L. Silber, and K. Schlienger. 2007. Protection.
This stability itself varies among different cell types as, for instance, neutrophils have highly lobulated nuclei and also have higher relative concentrations from the Lamin B2 subtype (12), which may be the least stable of the various Lamin subtypes (13, 14)
Recently, MNs packed with a conserved individual melanoma antigen with assembled PEMs buildings were developed [120]


text:
Salal is a shrub, native to western North America and planted widely in Britain, whose scientific name is Gaultheria shallon.

Salal may also refer to:
Salal, Chad, a city in Bahr el Gazel Region
Salal, Somalia, a region in Somaliland