text:
Exemestane blocks mesothelioma growth through downregulation of cAMP
Tag: Rabbit polyclonal to ATF1
Supplementary Components1. related. At increasing inoculum figures, mortality strikingly improved from
Supplementary Components1. related. At increasing inoculum figures, mortality strikingly improved from 15% to 31% and 100% in Nrf2 null mice, whereas all WT mice survived, and Nrf2 null mice experienced a defect in clearance, particularly in the intermediate dose. The mortality was due to enhanced lung injury and higher systemic response. Gene profiling recognized differentially controlled genes and pathways in neutrophils and lung cells, including those involved in redox stress response, metabolism, swelling, immunoregulatory pathways and cells repair, providing insight into the mechanisms for the greater tissue damage and improved neutrophil accumulation. Intro The transcription element Nrf2 (nuclear element erythroid-derived 2-like 2, after hyperoxia (9). Our initial studies shown that neutrophils communicate Nrf2 (10), but its practical significance in regulating gene transcription within these cells has not been evaluated. These studies tested the Actinomycin D cost hypothesis that Nrf2 regulates lung sponsor defense during bacterial pneumonia induced by S. for 6 or 24 hours. Gene profiling was performed in both the whole lung cells and the lung neutrophils isolated from your PBS- or (19, ATCC 49619) was purchased from American Type Tradition Collection (Manassas, VA). was produced at 37C with 5% CO2 on trypticase soy agar comprising 5% defibrinated sheep blood. Suspensions of were prepared in PBS, and bacterial dosage was estimated predicated on the absorbance from the bacterial suspension system at 600 nm. Pneumonia was induced by intratracheal instillation from the ready bacterial suspension system into the still left lung (2.3 l from the bacterial suspension per g mouse bodyweight). The amount of bacterial CFU instilled was quantified by plating serial dilutions from the bacterial suspension system on agar plates, such as the lungs and spleens (make sure you find below). Lung morphometry At 6 or a day after instillation of for ten minutes at 4C. An aliquot from the causing supernatant was attained for dimension of antioxidant capability. An identical level of RIPA buffer was put into the rest of the homogenate after that, the test was spun and TBARS had been assessed in the supernatant. All examples had been kept at -80C ahead of executing the assays. Quantifying DAMPS and various other markers of alveolar damage in the BAL liquid At 6 Actinomycin D cost or 24 h after instillation of (5.8-15 106 CFUs/mouse) in Nrf2 null and WT mice, the pulmonary vasculature was flushed with PBS, and an individual BAL was performed by instilling 0.9 ml PBS comprising 2 mM EDTA per 22 g mouse body weight into the lungs through the trachea. BAL fluid was spun at 300 at 4C for 5 minutes, and the cell-free supernatant was collected and stored at -80C until use. Thawed samples were spun at 15,000 for 2 moments at 4C, and the supernatant was collected and aliquoted for use in subsequent assays. Total protein was measured using the Bicinchoninic Acid Protein Assay according to the manufacturers Actinomycin D cost instructions (Sigma-Aldrich or Thermo Fisher Scientific, Waltham, MA). The levels of 23 cytokines/chemokines were measured using a multiplex assay within the Bio-Plex MAGPIX platform (Bio-Rad, Hercules, CA, USA). The levels of soluble RAGE, S100A8 and S100A9 were measured using a custom multiplex magnetic bead-based assay (R&D Systems, Minneapolis, MN) within the Luminex platform (Luminex, Austin, TX). Soluble ICAM-1 Rabbit polyclonal to ATF1 (sICAM-1, CD54) was measured using an ELISA (R&D Systems). Extracellular double-stranded DNA was measured using Quant-iT PicoGreen dsDNA Assay Kit (Life Systems, Grand Island, NY). Immunostaining and circulation Actinomycin D cost cytometry Isolated lung cells were incubated with FITC-conjugated antibody to the neutrophil-specific marker Ly6G (clone 1A8, BD Pharmingen, San Diego, Actinomycin D cost CA, USA) or the appropriate isotype control at 4C in the dark. Cells were washed with staining buffer to remove unbound antibody. Labeling with Alexa Fluor 647-conjugated Annexin V and 7-AAD were performed according to the manufacturers instructions (BioLegend, San Diego, CA). Stained samples were analyzed using a CyAn ADP circulation cytometer (Dako/Beckman-Coulter, Brea, CA, USA). Circulation cytometry data were analyzed using FCS Express software program (De Novo Software program, LA, CA, USA). Isolation of neutrophils.
Actinomycin D cost
Rabbit polyclonal to ATF1
Dendritic cells (DC) have the potential to instigate a tumour-specific immune
Dendritic cells (DC) have the potential to instigate a tumour-specific immune response, but their ability to prime na?ve lymphocytes depends on their activation status. activation. Interestingly, IL-10 is present in both ascites from patients with malignant OC and in peritoneal fluid from patients with benign ovarian conditions and both fluids have similar ability to reduce TLR-mediated DC activation. However, depletion of IL-10 from ascites revealed that A-966492 the presence of paracrine IL-10 is not crucial for ascites-mediated suppression of DC activation in response to TLR activation. Unlike IL-10, PGE2 is absent from peritoneal fluid of patients with benign conditions and selectively reduces TNF induction in response to TLR-mediated activation in the presence of OC-associated ascites. Our study highlights PGE2 as an immunosuppressive component of the malignant OC microenvironment rendering PGE2 a potentially important target for immunotherapy in OC. Introduction Chemo-resistance in patients experiencing relapse after conventional therapy is frequent in OC and constitutes an important factor correlating with poor prognosis [1]. Thus there is an urgent need for alternative intervention strategies. Immunotherapeutic induction of anti-tumour immunity represents a promising treatment option in OC [2]. However, in order to develop robust and effective immunotherapy protocols for clinical use, a better understanding of the obstacles for anti-tumour immunity induction in OC posed by the immunosuppressive A-966492 tumour microenvironment is required. Serous epithelial OC is the most common histological subtype of OC comprising 85% of all cases. Although an aggressive tumour with invasive potential, its metastases remain largely restricted to the peritoneal cavity even in late clinical stages, frequently accompanied by the formation of ascites. The localization to the peritoneal compartment allows the tumour to create an enclosed immunosuppressive milieu that it can thrive in, and the promotion of such an immunomodulatory local environment is a central mechanism of tumour escape and progression in OC [3C6]. The OC microenvironment represents a complex immunosuppressive network of cytokines and other factors. Many of the immunosuppressive components such as IL-10, transforming growth factor (TGF and leukemia inhibitory factor (LIF) are soluble factors that are abundant in OC-associated ascites [6C9]. Vascular endothelial growth factor (VEGF) A-966492 is part of this immunosuppressive network and promotes tumour growth by inducing angiogenesis and recruiting immature myeloid cells to the tumour tissue [10]. Similarly, pro-inflammatory cytokines such as IL-6 and TNF that are also present in the OC microenvironment, support tumour progression by influencing angiogenesis and tumour infiltration with myeloid cells [11, 12]. The recruited myeloid cells differentiate into tumour-associated macrophages (TAM) and immature DC characterized by the production of indoleamine 2,3-dioxygenase (IDO), and are capable of inducing regulatory T cells [13]. The peritoneal cavity of OC patients is infiltrated with a variety of leukocyte populations, and the immune cell composition within the tumour microenvironment impacts upon disease progression and has been reported to correlate with clinical outcome [14, 15]. DC are present in the A-966492 OC environment [16, 17] and as professional antigen-presenting cells (APC) they are thought to be pivotal for the initiation of tumour-specific immune responses because of their ability to take up and process tumour antigens and prime cytotoxic T cell (CTL) responses. However, the ability of DC to launch a potent anti-tumour immune response is dependent on their direct activation via pattern recognition receptors (PRR) such as TLR [18]. Despite the presence of damage-associated molecular patterns with the ability to trigger TLR-mediated responses such as HMGB-1 [19], the tumour microenvironment does not provide agonists for optimal TLR-mediated service of DC and DC-based restorative methods crucially rely on synthetic TLR agonists as mediators of effective DC service. In order to develop efficient immunotherapeutic strategies for Rabbit polyclonal to ATF1 treatment of OC A-966492 individuals, it is definitely vital to understand how DC integrate the opposing signals offered by strongly stimulating synthetic TLR agonists and immunosuppressive factors connected with the tumour microenvironment. There are many different DC subsets. Some reside in peripheral cells and have the ability to migrate to the draining lymph nodes whereas others are resident in lymphoid cells or circulate in the blood until they are recruited to sites of swelling [20]. However it is currently.
5- Transporters
Adenine Receptors
Angiotensin Receptors, Non-Selective
Ca2+-ATPase
Dehydrogenases
Deubiquitinating Enzymes
Dipeptidase
E-Type ATPase
Excitatory Amino Acid Transporters
Formyl Peptide Receptors
Glucose Transporters
Histone Acetyltransferases
Human Neutrophil Elastase
K+ Ionophore
L-Type Calcium Channels
LDLR
Low-density Lipoprotein Receptors
M3 Receptors
Mitogen-Activated Protein Kinase-Activated Protein Kinase-2
Monoacylglycerol Lipase
Neovascularization
Neuropeptide Y Receptors
Nitric Oxide, Other
Non-selective CRF
Opioid, ??-
Other Subtypes
Oxytocin Receptors
Serotonin (5-ht5) Receptors
Serotonin N-acetyl transferase
Finding best suited seed cells for bone tissue tissue engineering continues to be a significant task
Triple-Negative Basal-Like tumors, representing 15 to 20% of breast cancers, have become aggressive and with poor prognosis
Supplementary Materialscells-09-01325-s001
Ca2+ release from the endoplasmic reticulum can be an important element of Ca2+ sign transduction that controls several physiological processes in eukaryotic cells
2 3 4 6 a 180-220 kDa leukocyte common antigen LCA). CD45 antigen is expressed at high levels on all hematopoietic cells including T and B lymphocytes ACAD9 a member of the integrin a chain family with 165 kDa MW. which is expressed on NK cells Balapiravir Boceprevir BPTP3 BTLA DDR1 Dovitinib Dilactic acid granulocytes GW843682X Hbb-bh1 IGSF8 Iressa KLF4 antibody MET MK-0859 monocytes Mouse monoclonal to A1BG Mouse monoclonal to CD11b.4AM216 reacts with CD11b Mouse monoclonal to CD45.4AA9 reacts with CD45 Mouse monoclonal to CRTC3 Mouse monoclonal to MATN1 Nexavar NK cells and dendritic cells Palmitoyl Pentapeptide PIK-293 Prkd1 Rabbit polyclonal to ATF1 Rabbit Polyclonal to CLIC6 Rabbit Polyclonal to GPR174 Rabbit Polyclonal to HRH2 Rabbit Polyclonal to MARK Rabbit polyclonal to PIWIL3 Rehabilitation RELA SCH 727965 SL 0101-1 TAE684 U 95666E Vegfa


Peppers come in a variety of types, from black peppercorns to red to green to cayenne. And each has a different flavor, texture, and use. Here, we will focus on black pepper, what it is, and some of the things that you can use it for naturally to help solve problems that you may be having. In fact, pepper has many uses in medicine that people have utilized for many years. Pepper has been shown to help improve one's appetite, reduce stomach problems, and help mucus formation subside. One can mix a little pepper with honey to help a person with flu symptoms: cough, low appetite, and chills. Asthma can also be treated. Pepper is also a good treatment for high fevers, and if taken on a regular basis, can improve strength, vitality, and vigor. Pepper also has been known to help with insomnia, and is great to give a new mom after delivery to clean out the uterus. Pepper has also, for hundreds of years, been used as an anti-inflammatory. It can help the body to absorb nutrients from foods better. Pepper is also loaded with its own nutrients, including calcium, zinc, iron, potassium, and magnesium. Pepper is also full of many vitamins, including many of the crucial B vitamins that we need each day. Lastly, pepper can be used in the dental field to prevent swelling of the gums, as well as for an antiseptic for tooth decay. When using pepper as a treatment, one should be careful to stay away from alcohol, tea, tobacco, coffee and excess salt. So, now that you know pepper can be quite the commodity for a variety of reasons, go out there and enjoy its flavor and many health benefits.
4.What beverages stain your teeth?


Amanda is about to BLOW!!
It became a total nuthouse after the nomination ceremony. Amanda blew a fuse! She storms up to the HOH, demanding an explanation from GM as to why her and McCrae were nominated. Amanda says to GM it doesn't make sense, we were never coming after you. GM tells her Aaryn told her a lot of stuff. Amanda says Elissa sent home Nick and just sent home your best friend. She tries to reason that it makes no sense. GM says this is a good game move. She says she can't think about Nick going home and play emotionally, she has to play good game moves. Amanda says that is a good game move putting Elissa up. Amanda says putting up Elissa would have caused no target for herself, because everyone wants Elissa gone. She explains now she has everyone after her for putting up McCrae and herself. She tells GM that she is going home next week because either her or McCrae will stay. She then says just wait because when the veto is won, one of us will come down, and no matter who you put up, we will both end up staying in the house. She says your replacement will be going home. While this conversation has been happening, Judd and Andy have entered the room, and are just sitting quietly listening. Judd then jumps in and says why, because you are running the house? Amanda says now she sees whats going on and leaves the room. Judd and GM follow with Andy shortly behind. Judd is yelling at Amanda who has made it down to the kitchen, saying so what we should all just pack our bags and hand you the money. Amanda says that's not what I'm saying. Judd says you just said I would be going home. Amanda fires back, I never said your name! Judd says, you just said it. GM just says again this is a good game move, that's it.
Amanda then heads into the Have-Not room to cry. McCrae joins her where Amanda continues to say it makes no sense. She says that Aaryn told her that Elissa and GM were working together and she was right. She then says though that Aaryn threw her under the bus. They kiss a lot with Amanda saying over and over she doesn't want to stay in the house another week with that stupid joker b**ch. (She is referring to Elissa.) Amanda says she just wants to go home now.
The week should be CRAZY! Amanda seems to have calmed this evening, in what appears to be acceptance that either her or McCrae are going home. I have no doubt though in true Amanda fashion, she will explode more as the week goes on. I will keep you updated on all her lunacy this week!
She thinks she is the queen bee , hope the worker bee's take her out this week.
Yeah, she's a "Queen Bee" alright... A QUEEN BEE-OTCH!!! But I'm unsure about which workers bees you're speaking about... the ones inside the house, or the ones in production that have been carrying her ALL SEASON LONG! Talk about a corporate conflict of interest!
Amanda thinks she is one of the nicest people in the game which she is not . I'm so glad Gina Marie has won the HOH and takes the queen bee out this week . It was time for someone to make a big move in the Big brother house !
That's hilarious that Judd called her out for thinking she runs the house.
Amanda should have been kicked out the house for her threats towards Elyessa. Why she's still in the house. I don't know.


text:
Березники — упразднённая в 2005 году деревня Михайловского сельсовета в Архангельском районе Республики Башкортостан.

История
по состоянию на 1 июля 1972 года входил в Михайловский сельсовет. Преобладающая национальность — русские.

по состоянию на 1 сентября 1981 года входил в Михайловский сельсовет. Преобладающая национальность — башкиры.

Закон «О внесении изменений в административно-территориальное устройство Республики Башкортостан в связи с образованием, объединением, упразднением и изменением статуса населенных пунктов, переносом административных центров» от 20 июля 2005 года № 211-з постановил:

ст. 4. Упразднить следующие населенные пункты: <…>
2) в Архангельском районе <…>
а) деревню Березники Михайловского сельсовета

География
Находилась в лесистой местности у р. Лемеза.

Географическое положение
По  состоянию  на 1 сентября 1981 года расстояние до :
 районного центра (Архангельское): 52 км;
 центра сельсовета (Михайловка): 12 км;
 ближайшей железнодорожной станции (Равтау): 42 км.

Ссылки
 Березники на географической базе данных GeoNames

Литература
Башкирская АССР : административно-территориальное деление на 1 июля 1972 года : [справочник] / Президиум Верхов. Совета Башк. АССР ; [сост. Н. Н. Кириллова, П. Ф. Максимов, М. Х. Мусин ; отв. ред. Б. А. Абдрахманов]. — Изд. 6-е. — Уфа : Башкирское книжное издательство, 1973. — 386, [2] с. : табл. преим., карты. — Алф. указ.: с. 327-387. С.31

Башкирская АССР : административно-территориальное деление на 1 сентября 1981 года : [справочник] / Президиум Верхов. Совета Башк. АССР ; [сост. Н. Н. Исаев, З. З. Харрасов, М. З. Шаймуратов ; отв. ред. Ф. Ш. Хисматуллин]. — Уфа : Башкирское книжное издательство, 1981. — 382, [2] с. : табл. преим., карты. — Алф. указ.: с. 326-383. С.37
Исчезнувшие населённые пункты Архангельского района
Населённые пункты, упразднённые в 2005 году

redpajama_set_name: RedPajamaWikipedia


text:
AMRI fire: Two Kerala nurses save 8 patients, die trying to rescue 9th
Two young nurses from Kerala, who were working in the AMRI Hospital in Kolkata, saved eight patients before their own lives were snuffed out while trying to rescue another victim.
Remya and Vineetha
Nurse called home in Kerala before dying in AMRI Hospital
When 24-year-old Remya called her home here from AMRI Hospital in Kolkata in the wee hours on Friday, her mother did not think that she was hearing from her daughter for the last time.
Though Remya s
Stir in Idukki, TN to check dam
The Idukki district experienced a series of mild tremors with a magnitude of 2.7 on the Richter scale in the early hours of Saturday, heightening the anxiety about the safety of the 116-year-old Mulla
Mullaperiyar: Kerala minister to meet PM next week
Kerala Revenue Minister Thiruvanchoor Radhakrishnan will meet Prime Minister Manmohan Singh and senior Union Cabinet ministers next week to press Kerala's demand for a new dam at Mullaperiyar in place
Mild tremors shake Kerala's Idukki district
Mild tremors were felt in Upputhara and Peerumedu taluk areas of Idukki district on Friday, leaving cracks in some houses.
The magnitude of the first tremor at 5.27am was 2.8 on the Richter Scale, w
KSEB engineer's body found in car
The body of a Kerala Electricity Board engineer was found in his car in front of a private hotel at Kodimatha here, police said today.
The body was identified as that of Vinod (40), sub-engineer

redpajama_set_name: RedPajamaCommonCrawl


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Per Capita Cost of the UK Monarchy
Thread: Per Capita Cost of the UK Monarchy
I suggest it be ditched now before it is usurped by the POTUS next month.
https://www.cbsnews.com/news/trump-u...i-theresa-may/
That's just one existential cost to the public. There are many more such as this, https://www.theguardian.com/uk-news/...m-palace-works.
The only benefit I can see for the general public is tourism. Is it worth the cost?
I have not so far found a number that includes security costs.
The Crown Estate isn't public money. It's a... thing. Property of whoever the current reigning monarch is. Something like that? I'm really indifferent on whether we should be a Republic but the cost of the monarchy is piss-all compared to the scale of the overall economy, or government spending. It's not a good argument. If we had a president or a lord protector or whatever the fuck instead as head of state, you think that would magically be free? That they wouldn't need security?
Also, Trump's not coming next month, in May: that is actually the surname of the Prime Minister. He's coming in June.
Also, we're not changing our government just because you lot can't elect a proper president. Get his ass impeached by June if you're that bothered about it.
wiggin
Trump's bullshittery aside, I've always been a vicarious republican when it came to the UK. And I had an argument a while back (in which I was roundly criticized) for suggesting that the Crown Estate should actually be the property of the UK government and not the monarch. But at the end of the day, other than offending democratic sensibilities and being occasionally ludicrous, I suppose the royals don't do all that much harm - the actual budgetary outlay is relatively manageable.
"When I meet God, I am going to ask him two questions: Why relativity? And why turbulence? I really believe he will have an answer for the first." - Werner Heisenberg (maybe)
I'm a republican but out of principle.
The cost argument is ludicrous, a President/whatever would cost a comparable amount. And even if we took the Crown Estate into public hands which I think it should be [though legally it is the personal property of the monarch] then we would have to pay the costs for maintaining the Palaces etc
For what its worth I don't believe in the tourism argument either. Yes people come to stare at Buckingham Palace [and for 1 month a year can go inside], but then again people go to Paris year-round and actually go inside Versailles.
Ultimately the cost and tourism arguments are redundant to the debate. What should matter is simply whether we want to keep the monarchy or not. And like virtually all British republicans I recognise that's not a debate worth having while QEII is alive.
rille
Sweden is also a Monarchy, I think we should ditch that too.
I seriously have a hard time to see any advantage that would motivate it in a modern world over the principle, as to say.
Flixy
I'm also Republican by principle. However, our previous queen and current king are as far as i can tell doing a pretty good job, so i don't really care that much at the moment. My main problem with royalty is that there's not much you can do if they're not good or causing problems.
Keep on keepin' the beat alive!
We're a Constitutional Monarchy. If the monarch started causing problems we could very rapidly become a republic.
gogobongopop
I'd be really disappointed if we lost our monarchy. Something that oozes so much history and tradition is interesting and kinda romantic.
I'm a bit frustrated that I feel this way because objectively I don't really see the value they bring, but I know that I'd probably feel more regret and sadness if we got rid of them.
Shrug.
I think there's some value in the head of state being non-political. And if they're non-political, there's not a whole lot of point in electing them.
Plenty of parliamentary democracies have non partisan presidents as head of state - and it seems to work out without a hereditary system.
That's my thoughts as well. Which in turn keeps them in line, i guess.
Originally Posted by wiggin
Sure, but it's a valid question: what is the point of electing a non partisan head of state?
They're usually "non-partisan", not non-partisan. They're either elected politicians with prior political affiliations and thus inherently partisan figures, or else appointed by parliament/the government and therefore also partisan. I'm not, like, an expert on the political history of every state that uses these parliamentary republic style systems but I don't think there's a president anywhere where the tradition of neutrality for the head of state is quite as strong as it is here: Elizabeth II doesn't seem to ever express opinions on anything publicly.
That said, it remains to be seen how much of the tradition comes from institutions and how much comes from her personal conviction, since basically the entire modern history of the institution of the monarchy has been under her, so we'll see how her successors do with it.
Hazir
Amsterdam/Istanbul
That in itself should be a reason to abolish the monarchy: keeping a person in a position where he is not to express any thought on current affairs is tantamount to violation of human rights.
Other than that I see the constitutional monarchy as a harmless relic. And as soon as it becomes a nuisance we can get rid of it.
Greece shows us that there is a kind of politician worse than the ones that break their election promises; the ones that keep their election promises.
If the monarch wants to express thoughts on current affiars they can do so. Abdication is an option.
Looks like some of the monarchy is beginning to step away of their own accord,
https://www.msn.com/en-us/lifestyle/...m2A?li=BBnb7Kz
The true - and most burdensome - cost of the English monarchy is the utter vileness it brings out in the English public.
Originally Posted by Aimless
The true - and most burdensome - cost of the English monarchy is the utter vileness it brings out in the English public. press
I considered saying that instead, but the two exist in symbiosis, and it's not like the vileness of the press arose ex nihilo.
Mmmm to some degree I suppose.
The UK press is rabid and vociferous in its own right though, tripping over each other to dig the latest dirt, hack the latest voice messages, rummage through the seediest celebrity dustbins to get the scoop before a rival publication can. The public will consume whatever is published.
It is the UK press that has the reputation here. I suspect that (a particular segment of) the UK public has become so inured to the vileness over the last few decades they don't know what a respectful press looks like. If all you are fed is fast food, then all you will continue to eat is fast food if it is available. In that I suppose is your symbiosis.
As for Harry and Meghan? *shrugs* Young famous modern couple in a modern world struggling in the limelight duty-bound to the requirements of an ancient and outdated institution.
I mean, they wouldn't do if it didn't shift newspapers, so clearly there's an appetite for it.
I was speculating earlier today if there was anything they could possibly do in their royal/celebrity coverage that was so blatantly false, intrusive, unfair and/or outright racist that it would get people to actually stop buying their newspapers in any significant numbers.
I concluded that there was not.
It's strange though that the UK has such a crappy press.
Thinking about it, i can think of one instance which has stopped large sections of the public buying tabloid papers - Liverpool, Hillsborough and the Sun over the football disaster ...
Many, if not most, visitors arrive into Liverpool by train. As you exit Liverpool Lime Street, like most stations, you come face to face with a long line of taxis, eager to capitalise on weary and confused travellers. But, unlike most stations, nearly every taxi has the words "Do not buy The Sun" emblazoned on the side in place of an advert or the company's phone number.
The taxi has taken you to wherever you want to be in Liverpool. Perhaps that's the Tate at the Royal Albert Dock, one of the cathedrals that can be seen from all over the city like overbearing parents, or perhaps you want to go to Anfield, home of Liverpool Football Club.
One thing in common with all these places, and in fact everywhere in Liverpool, is that you won't see anyone buying, selling, or reading The Sun. Even major supermarkets such as Tesco have stopped selling the newspaper in the area citing "no demand".
The reasons are clear. After the Hillsborough disaster in 1989 in which 96 Liverpool fans were crushed to death in overcrowding, the Murdoch-owned newspaper printed pages of false claims that not only blamed Liverpool fans for the disaster, but accused them of urinating on police officers and other fans, beating up officers attempting CPR, and pickpocketing the dead. These reports have since all been proven as fabrication.
Last edited by Timbuk2; 01-15-2020 at 09:11 AM.
Originally Posted by Timbuk2
I've never bought or read The Sun and never will. Its a shame the rest of the country doesn't follow our example. Its not just Liverpool itself, I'm from the other side of the water (Birkenhead) originally and you won't find The Sun being bought, read or sold all across Merseyside.
I'm not going to sit here and tell anyone that Liverpudlians aren't like 9000% justified in their anger at the Sun, but it was only because it targeted their community specifically.
Absolutely agreed. And targeted them in a vile manner too. People do have a tendency to take a special interest in that which targets them. Hence groups like Hacked Off too, they're not bothered by principles but because they're upset at what happened to them (some of whom I have little sympathy with).


Four Stroke Engine Animation Download User Manual - View and Download Toyota Sienna 2016 user manual online. Sienna 2016 Automobile pdf manual download.. Delegation strategies for the NCLEX, Prioritization for the NCLEX, Infection Control for the NCLEX, FREE resources for the NCLEX, FREE NCLEX Quizzes for the NCLEX, FREE NCLEX exams for the NCLEX, Failed the NCLEX - Help is here. A steam engine is a heat engine that performs mechanical work using steam as its working fluid.The steam engine uses the force produced by steam pressure to push a piston back and forth inside a cylinder. This pushing force is transformed, by a connecting rod and flywheel, into rotational force for work.The term "steam engine" is generally applied only to reciprocating engines as just.
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1000 ∞ SVG Uniform Tile Patterns : Tessellation A tile pattern is made up of a single tile unit, repeated to fill the desired area. The tile unit is comprised of tessellated regular/convex polygons.. Feb 4 : The paint kit for the EA-6B Prowler is now available in the Freeware Section. Feb 1 : The Mi-24D Hind page now shows all the final screenshots ! This great product is now very close to release, just the user manual and the sounds need to be finalised.. Cigarette tobacco Injectors, Roll Your Own Magazine, The Magazine of Roll Your Own Smoking, Injector Reviews, Excel, EXP1000.
A steam locomotive is a type of railway locomotive that produces its pulling power through a steam engine.These locomotives are fueled by burning combustible material – usually coal, wood, or oil – to produce steam in a boiler.The steam moves reciprocating pistons which are mechanically connected to the locomotive's main wheels (drivers). Both fuel and water supplies are carried with the. Liste von Dateiendungen mit alphatisch sortiert mit Erklärung. Was bedeutet die File Extension ?. Autoblog brings you automotive news; expert reviews of cars, trucks, crossovers and SUVs; and pictures and video. Research and compare vehicles, find local dealers, calculate loan payments, find.


Climbing five of the seven summits in the world was not enough for Luke Richmond. The former Australian Army infantryman needed to test the limits of his fitness – something beyond the tough routines he doles out for guests at Tiger Muay Thai and MMA Training Camp in Phuket, Thailand on a regular basis. He found it in qualifying for the CrossFit Games: Asia Regionals – one of the toughest competitions on the planet.
The event pulled in 50 of the top CrossFit athletes on the continent, with the winner earning an invite to the World CrossFit Games in Southern California in July. The three-day event took place in South Korea and, with a round of cuts at the end of each day, only 22 were left standing in the end. Despite a slow start, Richmond ended up placing 5th – not bad for someone who only took up the sport a year ago.
Richmond sat down for a quick chat shortly after the competition to talk about this unique experience.
How does it feel coming in 5th after your first time in the competition?
Did you know anyone there beforehand?
How was the competition, is it more you competing against them or against yourself?
The first workout out you came in 27th out of 50, your lowest placement by far. Any thoughts on that?
Mentally, how was it losing your first workout?
How do you think this experience is going to benefit the people who take your classes at Tiger Muay Thai and MMA Training Camp?
It just all flows down hill. What I learn I pass on straight away. Being around guys who are competing is going to change the way I coach in small parts. Obviously, that's going to benefit the client as well. And that's what fitness and training is all about, there's no one way – it's a constantly evolving training method.
When you started CrossFit did you think you you were going to do this?
Not at all. When I discovered CrossFit I thought it was just good fitness, great for mountains. Now, I think about how I trained before and it just felt like a waste of time. It's very much an addiction, it's not a hobby or something you do before summer to look good. It's a lifestyle as the sport of fitness to keep you healthy for the rest of your life. The competition is addictive, once you get over the nerves it's really fun. I can't wait for next year.


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Press Foundation News
Maria Ressa, Jeffrey Sachs and Craig Newmark amongst speakers to address Trust Conference 2021
by Snober Abbasi | @snobers | Thomson Reuters Foundation
Monday, 15 November 2021 09:37 GMT
End of year message from our CEO
Looking back at Trust Conference: key moments and messages
Nobel Laureate Dmitry Muratov, Climate Justice Activist Vanessa Nakate and Nazanin Zaghari-Ratcliffe amongst speakers at Trust Conference 2022
UPDATED: Winners of 2022 Kurt Schork Awards in International Journalism announced
Thomson Reuters Foundation launches new journalism platform, Context
Nobel Peace Prize winner Maria Ressa, and an Afghan reporter who fled the Taliban, Zahra Joya, will speak alongside a distinguished line-up of speakers that includes world-renowned Professor of Economics Jeffrey Sachs and founder of craigslist, philanthropist Craig Newmark at the Thomson Reuters Foundation's flagship annual forum Trust Conference on 17 and 18 November.
They will join human rights defenders, innovators, media experts, policymakers and business leaders at the world-leading human rights forum, which brings together thousands of delegates from around the world.
The online forum comes at a critical juncture of the COVID-19 crisis and the UN climate summit and will address how the pandemic has deepened longstanding social and economic inequalities, has revitalised the drive for a sustainable future and has triggered an alarming spike in media freedom and human rights violations.
With 18 hours of live-streamed talks, plenaries and insight sessions, leading experts from a variety of disciplines will share new insights on shifting the post-pandemic economy onto a more inclusive and sustainable path, built on the principles of human rights, media freedom and climate justice.
They will share insights into how to tackle the world's most consequential challenges, which include the business case for economic inclusion, the path to zero emissions, the human cost of internet shutdowns and a legal network for journalists at risk.
This year's diverse speakers are at the forefront of their respective fields, and also include Dr Hilda C. Heine, Senator and former President of the Marshall Islands; Yvonne Aki-Sawyerr OBE, Mayor of Sierra Leone's capital, Freetown; Vivian Schiller, Executive Director of Aspen Digital; Javier Pallero, Policy Director at Access Now; Shamina Singh, Executive VP for Sustainability at Mastercard; Jorge Rubio Nava, Global Head of Social Finance at Citi; Danielle Belton, Editor-in-Chief of the Huffington Post; Lina Attalah, Co-founder of independent Egyptian news outlet Mada Masr; Alessandra Galloni, Editor-in-Chief of Reuters; Kanbar Hossein Bor, UK Coordinator Media Freedom Campaign & Deputy Director Democratic Governance, FCDO; Ma Jun, Founding Director of the Institute of Public and Environmental Affairs and Caoilfhionn Gallagher QC, Barrister at Doughty Street Chambers, specialising in human rights and civil liberties.
"The converging economic, health and climate crises are putting our democracies, people and planet under an existential threat," said Thomson Reuters Foundation CEO Antonio Zappulla. "But there is also a great opportunity for a coordinated global response - the success of which depends on how well we work with and learn from each other.
"Collaboration is key to the work of the Thomson Reuters Foundation, where we harness a unique combination of expertise in journalism and the law to support free, fair and informed societies. Together with experts from across sectors, Trust Conference is a critical platform to rethink how to address the power imbalance that defines the world's population and that derails global efforts to build inclusive economies, free societies and fair institutions."
In response to the ongoing deterioration of media freedoms, the Foundation will launch a new Legal Network for Journalists at Risk at the conference, an initiative in partnership with the Committee to Protect Journalists and Media Defence.
The Network comprises 15 organisations, and strategically coordinates different types of legal support to enable journalists and independent media outlets to continue to cover public interest stories and hold power to account without fear of retribution.
Additionally, the Foundation will unveil its partnership with UNESCO, the International Women's Media Foundation and the International News Safety Institute through which it has developed practical and legal tools for journalists, media managers and newsrooms to counter harassment.
"At UNESCO, we have a specific mandate to foster freedom of expression, the safety of journalists and access to information," said Guilherme Canela, Chief, Freedom of Expression and Safety of Journalists Section at UNESCO.
"Our research has shown that gender-based and misogynist violence against women journalists is pervasive online and offline. The sexist comments they receive are often combined with racist, homophobic, Islamophobic and antisemitic attacks that exacerbate the violence they are subjected to. Such violence can lead to self-censorship, and with less women journalists in the newsrooms, how can media reflect the diversity of opinions and voices of our societies?
"We hope to contribute to creating a safer environment for women journalists. Our collaboration with the Thomson Reuters Foundation is an example of this, and we are excited to publish this series of practical guides."
Now in its ninth year, Trust Conference reflects the Thomson Reuters Foundation's work in tackling the world's most complex societal issues, with a focus on socio-economic inclusion, sustainability, media freedom and human rights.
The programme and the speaker line-up of Trust Conference are available here. Register for your complimentary ticket here.
Platinum supporters: White & Case, People's Postcode Lottery and Postcode Justice Trust
Gold supporters: Internet Society and Jigsaw
Silver supporter: Humanity United
Changemakers supporter: Fondation Botnar
Building back more equitably in the aftermath of the COVID-19 pandemic
Tackling online sexual exploitation and abuse of women through a call for international standards
Supporting the non-profit sector amidst Lebanon's financial crisis
Powering affordable clean air in new markets through pro bono legal support


Use a PPI claims company and you'll need to fill in some forms at the start and provide documents associated with the loan/credit card, then they'll take care of processing the claim. This includes submitting the complaint, hitting deadlines, responding to the bank, dealing with issues and taking the claim to the FOS if necessary. They will, of course, take a fee – usually around 25% + VAT.
Claim back PPI yourself, and you're responsible for all of the above, but you won't pay a fee if you win a payout. Back in 2012 around 75% of claims brought to the FOS were through PPI claims companies, but that figure is dropping as more and more free advice and information becomes available. Many people do claim back their mis sold PPI payments themselves but in order to make a PPI complaint you first need to know if you've been paying for PPI.
So that's how to make a PPI claim yourself – how smoothly it goes depends on the lender, their workload, the competence of their staff and how accurate you are with your form-filling. Remember to put the right address on when you took out the loan, add the joint account-holder if there was one and spell everything correctly – these are common mistakes that we see and banks LOVE mistakes as they're a great excuse to delay responses and payouts.


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Report: TennCare 'Not Financially Viable'
A management consulting firm hired to evaluate the financial viability of TennCare, the state's troubled Medicaid program, issued the first of a two-part report on December 11. The prognosis was bleak.
"Our assessment is that, even with current and planned improvement efforts and solid program management, TennCare as it is constructed today will not be financially viable" over the five-year evaluation horizon, concluded analysts for New York-based McKinsey & Company.
"TennCare will consume 36 percent of total state appropriations in fiscal year 2008 (up from 25 percent in 2003)," concluded McKinsey & Company, "and its cost growth in that year will represent 91 percent of new state tax appropriations."
"This has been a sobering day for me," said Tennessee Governor Phil Bredesen upon receiving the consultants' report. "The news is not good."
Bredesen had asked BlueCross BlueShield of Tennessee, Hospital Corporation of America, the Tennessee Farm Bureau Federation, 22 hospitals within the Tennessee Hospital Association, and Vanderbilt University to fund a study of TennCare. The group engaged McKinsey & Company to conduct the evaluation.
Ambitious Program
Launched in 1994, TennCare represents, the consultants write, "an historic effort to implement managed care for Tennessee's entire Medicaid population and expand insurance coverage to the state's uninsured and uninsurable residents." The program's budget has increased dramatically over the past decade and currently rests at $6.9 billion, of which the state pays $2.1 billion. The federal government picks up the remaining cost.
McKinsey & Company project the program's costs will reach between $11.8 and $12.6 billion by 2008. Program design features, program execution, and the overall health care environment are cited by the consultants as contributing factors to the program's growth. For example,
TennCare's benefits have few limits. "It's really one of the only programs that has, almost across the board, no limits on scope and duration of coverage," said Vivian Riefberg, a partner in McKinsey & Company's Washington DC office. While most state programs limit the number of drug prescriptions an enrollee can fill per month, limit the number of hospital days the program will pay for, or require substantial co-pays, TennCare services are provided "as medically necessary," with no ceilings. TennCare requires co-pays only from its non-Medicaid beneficiaries. McKinsey & Company estimates increased prescription drug costs alone will account for 56 percent of TennCare's growth between 2004 and 2008.
TennCare's design provides for inadequate cost control measures. For most services–including inpatient, outpatient, and home health care–the state works through managed care organizations (MCOs) rather than provide the services directly. According to McKinsey & Company, the cost controls implemented by the MCOs have been "inadequate." According to the report, "a series of high-profile MCO bankruptcies … left providers absorbing financial losses for millions of dollars in unpaid claims." In July 2002, the state assumed the financial risk for all TennCare enrollees, and the MCOs now operate as administrators only.
Ticking Bomb
"The TennCare bomb has been ticking away for years, keeping no secrets about its volatility," editorialized the Memphis Commercial Appeal in December. Health Care News has covered the TennCare story for years, documenting several reasons for the program's failure:
It is far too ambitious, enrolling too many people. "TennCare insures 1.3 million residents–a higher percentage of a state population on a Medicaid expansion program than anywhere else in the country," wrote the McKinsey & Company consultants. Currently, 24 percent of the state's population is enrolled in the TennCare program. Nearby states, such as Alabama, Kentucky, Mississippi, and Missouri, enroll roughly one-third to one-half as many people in their Medicaid programs.
TennCare enrolls a higher percentage of adults than children. In most other states, children represent more than half of the Medicaid beneficiary population. On average, adult Medicaid beneficiaries require more care than do children.
TennCare enrolls all high-risk and medically uninsurable residents, as the state abandoned its stand-alone high-risk insurance pool. While middle- and upper-income TennCare enrollees with pre-existing conditions do pay monthly premiums, those premiums are not risk-based and never generate the revenue needed to cover actual medical costs.
TennCare provides generous benefits, better in some respects than the plans offered by some private-sector employers. Although many employers, for example, do not offer prescription drug coverage, 22 percent of TennCare's budget pays for the drug benefit.
TennCare's generosity acts as a magnet, drawing in an uninsured population from surrounding states. And the relative ease with which sick people can qualify for TennCare–one need only document having been turned down for private insurance–the system encourages people to wait until they need medical care before obtaining coverage. Many healthy Tennesseans have dropped private insurance knowing they will qualify for TennCare after they get sick.
Other factors beyond the state's control have contributed to TennCare's woes. Although health care spending moderated in the mid-1990s, most observers predict escalating health care cost increases in the future, for both public- and private-sector health care programs, for several reasons:
Advanced medical technologies are driving hospital spending up as physicians are now able to do more than they used to.
New federal and state benefit mandates require Medicaid to cover products and services otherwise not provided.
Utilization of prescription drugs is rising rapidly as new drugs are being discovered and aggressively marketed.
The aging of the nation's population means more people, especially those with lower incomes, will face more chronic health problems in the future.
Reform Needed
"There can be no more delays in addressing the TennCare problem," warned the Commercial Appeal in December. "The administration and the General Assembly have known the program was in a critical state for some time. They must now find the will to act, in a bipartisan fashion, and prevent the collapse of a program that was born of the best intentions and now is in critical need of reform."
The second part of the McKinsey & Company report, expected in January, will offer recommendations for making the program viable. Bredesen, who would not discuss possible TennCare reforms with Health Care News in advance of the consultants' report, nevertheless promised "far-reaching" solutions, rather than short-term fixes, are in the works.
One immediate fix would be to drop from TennCare the 250,000 enrollees not eligible for Medicaid. Such a move would solve the problem for only a year and a half, said the governor, leaving unaddressed the underlying issue of 15 percent annual growth in TennCare costs.
The governor said he is trying to develop solutions while being "sensitive" to the fact TennCare has helped thousands of people. "I very much want to preserve it. It does help so many people. But in the end, we can't allow TennCare to bankrupt the state."
Conrad F. Meier is managing editor, and Diane Carol Bast is editor, of Health Care News. Meier's email address is [email protected].
See "Reforming an Ambitious State Health Care System," Intellectual Ammunition, July/August 2000, http://www.heartland.org/Article.cfm?artId=170 and "Tennessee Taxpayer Revolt," Health Care News, August 2001, http://www.heartland.org/Article.cfm?artId=571.
The 38-page McKinsey & Company report, "Achieving a Critical Mission in Difficult Times — TennCare's Financial Viability," is available through PolicyBot. Point your Web browser to http://www.heartland.org, click on the PolicyBot button. and search for document #14205.
The consultants' 21-page explanation of their "Modeling Methodology and Assumptions" is also available through PolicyBot; search for document #14206.


Product prices and availability are accurate as of 2019-02-11 12:48:07 UTC and are subject to change. Any price and availability information displayed on http://www.amazon.co.uk/ at the time of purchase will apply to the purchase of this product.
We are proud to stock the marvelous Bob's Red Mill Whole Ground Flaxseed Meal Organic -- 16 oz.
With so many on offer recently, it is great to have a brand you can have faith in. The Bob's Red Mill Whole Ground Flaxseed Meal Organic -- 16 oz is certainly that and will be a excellent acquisition.
For this sale price, the Bob's Red Mill Whole Ground Flaxseed Meal Organic -- 16 oz comes highly recommended and is a regular choice with most people. Bob's Red Mill have added some excellent touches and this means good value for money.
Bob"s Red Mill® Organic Flaxseed Meal has a robust, nutty flavor and tastes really great! Two tablespoons added to your cold or hot cereal, pancakes, waffles, baked into your breads, muffins and quick breads brings you amazing nutrition. Also, please consider that several studies show flaxseed meal may be one of the most powerful natural cholesterol controllers yet discovered.


Discussion in 'Beginners Bootcamp' started by pjones, Jun 24, 2009.
Read Babypips.com and start doing demo and read all threads in this form.. i am also a beginner, i am doing the same thing.
Of course, since I wrote them, my opinion of how useful they are is totally unbiased.
Thanks for the help Nayani and Pharaoh. Will look into your suggestions.
In addition to that, try to watch forex news and continue posting your concerns here in this forum.
I'm still pretty new too!
Hi! I'm trading in a demo still, I am a female trader, I'm 23 and just moved back to Michigan from California to spend time with my family members who are getting old I friend introduced me to trading forex about a month back, and if it's a good as everyone makes it sound, I'll be entering an account using an EA in the next month. There's a company I've been introduced to (i'm not sure i can mention their name), and they are the first EA on the market to use Fibonacci. Their return on their managed account is up almost 90% since april! Pretty cool!
I'm sure I won't put a whole lot in to begin with, probably a few hundred dollars, I don't have a whole lot to risk!
On a side note, so i drove up to the Moneyshow in Toronto, CA with a few of the traders that created that EA... it wasn't too bad... but it really wasn't all that great. the only booth that even pertained to forex trading was MIG out of Switzerland. Everybody else was selling crap... and mostly Canadian crap so it didn't really pertain to me. But- it was cool to be in a place where people around me actually knew what trading forex was! Even one of our taxi drivers has an account! So funny!


Home inspectors and FHA inspectors differ in their objective and clientele.
4 What Will an FHA Inspector Look For?
The most fundamental difference between a home inspection and a Federal Housing Administration (FHA) appraisal/inspection is whom it is meant to assist. FHA inspections are conducted by FHA certified appraisers, and results are reported directly to the lender. A regular house inspection is performed by an accredited house inspector, and the findings are reported directly to the seller or listing agent or the buyer and buyer's agent.
FHA Inspectors provide a report to the lender and home inspectors provide a report to the buyer or seller that hired them.
The focus of an FHA inspection/appraisal is the value of the property, which can sometimes be impacted by needed home repairs. Therefore, the inspector reports on both. The whole purpose of this inspection is to protect the lender as well as the FHA from lending a buyer more money than the house is worth.
A home inspection's primary purpose is to locate and report needed repairs in a house that is on the market. Items examined will include, but are not limited to, plumbing, electrical, heating and cooling systems, roof and structural elements. The market value of the property is not part of the equation. If the seller or buyer wants that figure, then a separate appraiser needs to be hired.
The cost of a home inspection is typically $300 – $600, depending on the size of the property. The cost is also dependent on the area where the property is located. A hot market, such as San Francisco, will sometimes have increased prices for home inspections.
Also, the price will fluctuate depending on specific tests requested that might not be included in the standard inspection.
A typical FHA appraisal costs $300 to $500, depending on factors including the size of the house, whether it needs many repairs or is in good condition.
An FHA inspector/appraiser is required to be trained and approved by the FHA before conducting inspections for the agency.
A regular home inspector must also be licensed as such, but is not required to be FHA approved, nor can that inspector conduct any FHA inspections.
There are no restrictions on how an FHA or non-FHA home inspection should be priced. For the most part, the inspection companies and independent inspectors charge what the market will bear. In some cases, the inspection is priced per square foot. Other inspections might charge based on what condition the property is in.
What Is The Difference Between An Fha Inspection And A Home Inspection?
2018 Appraisal Rules for FHA – What Happens if the House Does Not Appraise for the Sales Price?
Realtor.com: How Much Does a Home Inspection Cost?
Cost Owl: How Much Does It Cost To Hire a Home Inspector?
, Candace. "What Is the Difference Between an FHA Home Inspection & a Regular Home Inspection?" Home Guides | SF Gate, http://homeguides.sfgate.com/difference-between-fha-home-inspection-regular-home-inspection-41502.html. 24 January 2019.


text:
Home page >>> Nord-Pas-de-Calais >>> Hauteville
Recommended accommodation - Hauteville, Nord-Pas-de-Calais, France
Hauteville, France: Apartments and villas nearby
Hauteville, France - General details
Rent a bike, golf courses, hiking paths
Hauteville, region of Nord-Pas-de-Calais - Distances
Hauteville - Paris: 157 km
Hauteville - Le Havre: 194 km
Hauteville - Strasbourg: 421 km
Hauteville - Grand Rullecourt (0+ accommodation units): 7 km
Hauteville - Dainville (2+ accommodation units): 11 km
Hauteville - Sainte-catherine-lcz-arras (1+ apartments): 15 km
Hauteville - Couin (1+ apartments): 15 km
Hauteville - Arras (6+ accommodation units): 15 km
Hauteville - Saint-nicolas-lcz-arras (0+ accommodation units): 16 km
Hauteville - Saint-pol-sur-ternoise (3+ accommodation units): 21 km
Hauteville - Hautecôte (1+ accommodation units): 21 km
Airport "Beauvais-Tille", town of Paris (Ryanair, Wizz Air): 96 km
Castle Couin, Arras, 14.8 km from the centre of town of Hauteville.
Museum de Beaux-Arts, Arras, 14.9 km from the centre of town of Hauteville.
Church Saint Laurent, Arras, 15.2 km from the centre of town of Hauteville.
Museum Louvres Lens, Lens, 24.9 km from the centre of town of Hauteville.
History museum Somme 1916, Albert, 29.8 km from the centre of town of Hauteville.
Hauteville - weather


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Eko-Ende (or Eko Ende, Eko-Ende) is a community in the Ifelodun Local Government Area of Ọṣun State, Nigeria.

Location

Eko-Ende has a tropical climate, with an average temperature of .
Average annual rainfall is , with peaks in July and September, and little rain between November and February.
Eko-Ende lies just west of the town of Ikirun.
The farming community lies on the Ikirun-Ogbomoso road, in-between Eko-Ajala and Ore communities.

Dam
The Eko-Ende Dam on the Otin River was impounded in 1973 to form a reservoir with a capacity of 5.5 MCM.
The headworks were designed to supply potable water to the communities of Oba, Eko-Ende, Eko-Ajala, Ikirun, Iragbiji and Okuku. The dam is an earth structure, completed in 1979, with a capacity of .

History
The Jalumi War of 1 November 1878 took place in the hilly country of the northeast of Osun State in the area that includes Ikirun, Iba, Inisa, Okuku and Eko-Ende. It was one of the series of civil wars in Yorubaland between 1793 and 1893.
The traditional ruler is the Elende of Eko-Ende. As of 2013 Oba Abdul-Rauf Adebayo  Ajiboye held this title.

References
Citations

Sources

Populated places in Osun State


IndianCAs by Ashwin Nagar: ICAI has issued today Guidance note on Accounting for Derivatives.
ICAI has issued today Guidance note on Accounting for Derivatives.
This Guidance Note is an interim measure to provide recommendatory guidance on accounting for derivative contracts and hedging activities considering the lack of mandatory guidance in this regard with a view to bring about uniformity of practice in accounting for derivative contracts by various entities.


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Gabriel Abed
Co-Founder & CEO, Bitt.com (Barbados Islands)
Gabriel, a Barbadian national, began exploring cryptocurrencies, and their underlying Distributed Ledger Technology, during his undergraduate study as early as 2010. An alumnus of the University of Ontario he received a Bachelor of Information Technology specialising in Cryptographics and Network Security. Enthralled by the potential of cryptocurrencies, and conscious of the revolution unfolding around him, he became an early adopter and lifetime evangelist. He capitalised on his 15 years of experience working in the software and technology field, founding BitEdge with its subsidiaries: Caridot (the largest and leading Caribbean domain name registrar) and websites.bb (a leader in custom website designs).
Bitt, his latest and most groundbreaking journey, is a FinTech company built around the twin pillars of global connection and financial inclusion. Gabriel is Co-founder and CEO and believes that Bitt offers unprecedented solutions to disruptive regional issues from remittance payments to providing much-needed access to e-commerce solutions. With a significant multimillion dollar injection from Overstock.com, the desire, grit and metal that Gabriel embodies has been recognised by global partners. Gabriel is now perceived as the leading regional advocate and authority on digital currency.
In February 2016, Bitt broke new ground by launching a digitised version of the Barbados dollar. The first ever global example of a digitised fiat currency being approved and embraced by a central bank. To date Gabriel has spoken at the Richard Branson's Blockchain Summit, the United Nations, the IMF and World Bank, the Commonwealth Secretariat, the regional ITU conference, the Barbados International Business Association and the University of the West Indies. Gabriel Abed is 30 years old.
WCF Geneva Week 2017, Day 1


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Berceni, Romania, Europe
longitude: 26° 7'
Nationality initiator(s) Romania
Inhabitants 110,000
Luica street
source: https://upload.wikimedia. org/wikipedia/commons/thu mb/f/f0/Berceni%2C_Buchar est_-_Luica_Street.jpg/80 0px-Berceni%2C_Bucharest_ -_Luica_Street.jpg
Boulevard C-tin Brancoveanu
source: https://en.wikipedia.org/ wiki/Berceni,_Bucharest
source: https://commons.wikimedia .org/wiki/File:Berceni,_B ucharest,_Romania_-_panor amio_(2).jpg
"Before the 1960s, Berceni was situated outside of Bucharest, in a very sparsely populated area where only a few rural properties were located, with the nearest landmarks being the long-gone Văcărești Monastery, and starting from the latter half of the 19th century, the Bellu Cemetery. In the interwar era, the Alexandru Obregia hospital was opened.
On 5 April 1964, the Scînteia announced plans for a new housing estate, being built specifically for the workers at the IMGB plant located nearby, which opened in 1963. Construction works began the same year, which brought many Lipovan Russians from the Dobrogea region of Romania, who worked with excavating and laying foundations for the buildings. The first dwellers moved in 1965 when the first apartment buildings (4 to 9 storeys high) were completed, although the housing estate had its shortcomings: the local market was not ready on time, so trucks with food supplies would come in the mornings for the residents. On the other hand, the Lipovans found multiple graves on the construction site of a school.
The construction of the 4-storey apartment blocks was done much faster due to the type of the buildings using prefabricated panels, in one of the first large-scale uses of prefabs in apartment blocks. The 9-storey apartment blocks used the more traditional construction methods. 5500 apartments were planned to be built in the first stage: the goal was achieved in 1968, but construction works were completed by around 1976. The buildings closer to Piața Sudului were also built at the same time.
The western half of Berceni (located closer to the Giurgiului housing estate) began to be constructed starting from 1971 using more austere 4-storey and 10-storey apartment blocks, being exclusively built with prefabricated panels, the construction of which was completed by 1981. The second stage had fewer green spaces and more buildings that were built closer to each other. A group of small houses was left undemolished, and it still exists today, because, according to the institute that planned this housing estate, it gave the area "a special characteristic".
Berceni also benefitted from a large shopping center (BIG Berceni) which opened in February 1975, various schools and multiple trolleybus routes that opened in the late 1960s. The second line of the Bucharest Metro began operating in the vicinity of the neighborhood starting from 24 January 1986, serving the Piața Sudului and Apărătorii Patriei areas, along with the IMGB industrial area; however this led to the trolleybus network of Berceni being isolated from the rest of the trolleybus network of Bucharest in 1987, in an attempt to re-engineer the ground transportation in the city by building district-based networks.
In the last stage, multiple apartment blocks were built nearby from 1982 to 1990 in various areas of the housing estate, especially on the Olteniței Avenue and Constantin Brâncoveanu Avenue. In the 1980s it was the largest working class housing estate in Southern Bucharest, being one of the main four large scale housing estates built in the 1960s.
After the Romanian Revolution of 1989, the housing estate became infamous for its high crime rates, although this issue has been less common in the last decade. Starting from 2016, a program was launched to rebuild the roads and renovate multiple apartment buildings."
source: https://en.wikipedia.org/wiki/Berceni,_Bucharest
2008 - 2023 disclaimer


If you got an opportunity to visit Portugal, do not miss this great chance. You will visit one of the most amazing and distinctive European countries with a warm climate and interesting history during your fun trips to Portugal.
The Fun Plan gives you some travel tips to make your trip even more unforgettable!


This weekend the teams took part in the Rapture Gaming Festival with huge success! The event was jam packed over the weekend with a wide range of things for the visitors to do, from competing for prizes to getting their hands on some retro gaming hardware and games.
The Games Hub took to the Indie section, where it was an excellent opportunity for the teams to get their games in front of the gaming public (as well as offering the odd bowl of sweets :)).
Nysko Games didn't stop all weekend as people couldn't get enough of their game The Dwarves of Glistenveld. Arplex Studios showed of their latest version of Rail Warriors. Teaboy Games had their imminent release of Pendulum, along with a rather cool Makey Makey controller! Flitch got a chance for the first public play of their puzzle game Klink. Newly founded Wayward Worlds demonstrated their online and local multiplayer Arenas of Magic. And finally the award-winning Sketchbook Games continued to show their leaps in progress of Lost Words.
We also held a "Best Indie of Show" award, that was kindly judged by the Colchester Institute. Sketchbook Games won first prize and Flitch Games Klink came second. Much deserved all round!
It was an amazing event and we pass on thanks to all the guys and gals at Fragers for putting on what was an amazing show. We can't wait for the next one!
Everyone is in preparation for the Norwich Gaming Festival in a couple of weeks time, where you can join us and play on some of the games from the Wednesday 31st till the 3rd!


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Real change requires system change- The fight for a left government
Posted by: Cillian Gillespie Nov 23, 2015
By Cillian Gillespie
After seven years and €31 billion worth of austerity, we are told that we are in the midst of an economic recovery. However, for most people this recovery means a new housing crisis, skyrocketing rents and the creation of low paid temporary jobs.
There is now a working poor in our society, with 25% of the workforce earning less than the living wage of €11.50 an hour. Ireland, like all capitalist countries, has seen a steep rise in inequality; in the last five years the richest 300 people have seen their wealth rise by an obscene €34 billion. In this same period austerity measure after austerity measure was implemented in the form of extra taxes and cuts to social services and expenditure.
All of this is the by-product of a capitalist system where the economy is organised for private profit not human need. Fundamentally the parties of the political establishment, who have been in power since 2008, accept the rationale of this system. During the crisis the consensus among all these parties was that austerity and the bailing out of the banking system to the tune of €64 billion was necessary and unavoidable. As long as parties such as these, that accept the logic of capitalism, are in power the interests of the 1% will be prioritised at the expense of our living standards.
Prioritise human need not profit
We need a government that is going to prioritise our needs. This means investing billions in a building programme to provide council and affordable houses, introducing rent controls, massively increasingly public expenditure on health, education and childcare to create jobs and reverse the brutal effects of austerity, and introducing a minimum wage of €12 an hour.
However if we are to meet the needs of the 99% a left government must find the resources to do so. The odious debt created by the property crash of 2008/2009 must be repudiated (Ireland spends €7 billion per annum on the interest on this debt). The corporate welfare of €9 billion per annum must be ended and a wealth tax on the super-rich must be introduced as well as increasing corporation tax from its pitifully low level. A government that takes these kind of measures must be prepared to challenge capitalism; a system based on the rule of the super-rich, bondholders, bankers and big business, both here in Ireland and in Europe. We cannot allow ourselves to be constrained by the logic and the rules of a system that seeks to impose austerity and cuts workers' wages so that the profits and wealth of a tiny elite can be maximised.
Lesson of Greece
There are salient lessons that be drawn from the period in the after the election of the Syriza in February. Less than six months after it was elected it had capitulated to the Troika and are now implementing austerity and a privatisation package of €50 billion.
From the very outset of its election the Socialist Party and our sister organisation in Greece, Xekinima argued that if austerity, the Troika and Greek capitalism were to be defeated Syriza would need to implement anti-capitalist, socialist policies. These policies would include implementing capital controls, nationalising the banking system and key industries under democratic workers control and management. The veracity of this argument was born out when these forces sought to engage in economic terrorism in the form of cutting off money to Greece's banks and through a flight of capital out of Greece in the months following Syriza's election.
Radical socialist policies
Capitalism cannot simply be defeated through parliamentary decrees, the power of working class people needs to be mobilised on the streets and in the workplaces. The potential for mobilising this power in Greece was illustrated by the fact that 61% voted no or "Oxi" in a referendum on the Troika's austerity package, courageously resisting the threats and blackmail of the institutions of European capitalism. On the Friday before the referendum a staggering 200,000 people assembled in central Athens in support of rejecting the new austerity programme.
There is growing desire for a radical break with the orthodoxy of neo-liberalism and austerity among working class and young people but it is imperative we do not repeat the mistakes of Syriza and once again betray the hopes and aspirations of the majority in our society. The real change that we need requires the active struggle of working class people allied with a radical left government based on socialist policies that breaks the stranglehold of a parasitic ruling class that dominate our lives.
left government Need not profit Oxi Syriza	2015-11-23
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