text:
Clinical trial accrual at initial course of therapy for cancer and its impact on survival
Nicholas G. Zaorsky, Ying Zhang, Vonn Walter, Leila T. Tchelebi, Vernon M. Chinchilli, Niraj J. Gusani
Department of Public Health Sciences
Cancer Institute, Cancer Control
Department of Biochemistry and Molecular Biology
Division of Biostatistics and Bioinformatics
Penn State Clinical and Translational Science Institute (CTSI)
Center for Statistical Genetics
Division of General Surgery Specialties and Surgical Oncology
Background: This retrospective cohort study sought to characterize the accrual of patients with cancer into clinical trials at the time of diagnosis and analyze the impact of accrual on survival. Methods: The National Cancer Database (NCDB) was queried for patients enrolled in clinical trials at their initial course of treatment for 46 cancers from 2004 through 2015. Descriptive statistics were used to characterize the accrual of patients with cancer in clinical trials at diagnosis, and Kaplan-Meier graphical displays, log-rank tests, odds ratios, and stratified Cox proportional hazards models were used to analyze the impact of accrual on overall survival (OS). Strata were defined using 10 variables. Model-based adjusted survival curves of 2 groups were reverse-generated based on a Weibull distribution. Results: Of 12,097,681 patients in the NCDB, 11,576 (0.1%) were enrolled in trials. Patients in clinical trials typically had metastatic disease (30.9% vs 16.4%; P,.0001), were white (88.0% vs 84.8%; P,.0001), had private/managed care insurance (56.4% vs 41.8%; P,.0001), had fewer comorbidities (Charlson-Deyo score 0: 81.9% vs 75.7%; P,.0001, and Charlson-Deyo scores 1-3: 18.1% vs 24.3%; P,.0001) compared with those not in trials. At a median follow-up of 64 months, enrollment in a clinical trial was associated with improved OS in univariate and stratified analyses, with a median survival of 60.0 versus 52.5 months (hazard ratio, 0.876; 95% CI, 0.845-0.907; P,.0001). Stratified analysis with matched baseline characteristics between patients enrolled and not enrolled in a clinical trial showed superior OS at 5 years (95.0% vs 90.2%; P,.0001). Conclusions: Enrollment in clinical trials at first line of therapy in the United States is exceedingly low and favors young, healthy, white patients with metastatic disease and private insurance who are treated at academic medical centers. Patients with cancer treated in clinical trials live longer than those not treated in trials.
JNCCN Journal of the National Comprehensive Cancer Network
https://doi.org/10.6004/jnccn.2019.7321
Managed Care Programs
Zaorsky, N. G., Zhang, Y., Walter, V., Tchelebi, L. T., Chinchilli, V. M., & Gusani, N. J. (2019). Clinical trial accrual at initial course of therapy for cancer and its impact on survival. JNCCN Journal of the National Comprehensive Cancer Network, 17(11), 1309-1316. https://doi.org/10.6004/jnccn.2019.7321
Zaorsky, Nicholas G. ; Zhang, Ying ; Walter, Vonn ; Tchelebi, Leila T. ; Chinchilli, Vernon M. ; Gusani, Niraj J. / Clinical trial accrual at initial course of therapy for cancer and its impact on survival. In: JNCCN Journal of the National Comprehensive Cancer Network. 2019 ; Vol. 17, No. 11. pp. 1309-1316.
@article{a9fea901fbea406faf51545605c5807d,
title = "Clinical trial accrual at initial course of therapy for cancer and its impact on survival",
abstract = "Background: This retrospective cohort study sought to characterize the accrual of patients with cancer into clinical trials at the time of diagnosis and analyze the impact of accrual on survival. Methods: The National Cancer Database (NCDB) was queried for patients enrolled in clinical trials at their initial course of treatment for 46 cancers from 2004 through 2015. Descriptive statistics were used to characterize the accrual of patients with cancer in clinical trials at diagnosis, and Kaplan-Meier graphical displays, log-rank tests, odds ratios, and stratified Cox proportional hazards models were used to analyze the impact of accrual on overall survival (OS). Strata were defined using 10 variables. Model-based adjusted survival curves of 2 groups were reverse-generated based on a Weibull distribution. Results: Of 12,097,681 patients in the NCDB, 11,576 (0.1{\%}) were enrolled in trials. Patients in clinical trials typically had metastatic disease (30.9{\%} vs 16.4{\%}; P,.0001), were white (88.0{\%} vs 84.8{\%}; P,.0001), had private/managed care insurance (56.4{\%} vs 41.8{\%}; P,.0001), had fewer comorbidities (Charlson-Deyo score 0: 81.9{\%} vs 75.7{\%}; P,.0001, and Charlson-Deyo scores 1-3: 18.1{\%} vs 24.3{\%}; P,.0001) compared with those not in trials. At a median follow-up of 64 months, enrollment in a clinical trial was associated with improved OS in univariate and stratified analyses, with a median survival of 60.0 versus 52.5 months (hazard ratio, 0.876; 95{\%} CI, 0.845-0.907; P,.0001). Stratified analysis with matched baseline characteristics between patients enrolled and not enrolled in a clinical trial showed superior OS at 5 years (95.0{\%} vs 90.2{\%}; P,.0001). Conclusions: Enrollment in clinical trials at first line of therapy in the United States is exceedingly low and favors young, healthy, white patients with metastatic disease and private insurance who are treated at academic medical centers. Patients with cancer treated in clinical trials live longer than those not treated in trials.",
author = "Zaorsky, {Nicholas G.} and Ying Zhang and Vonn Walter and Tchelebi, {Leila T.} and Chinchilli, {Vernon M.} and Gusani, {Niraj J.}",
doi = "10.6004/jnccn.2019.7321",
journal = "Journal of the National Comprehensive Cancer Network : JNCCN",
publisher = "Cold Spring Publishing LLC",
Zaorsky, NG, Zhang, Y, Walter, V, Tchelebi, LT, Chinchilli, VM & Gusani, NJ 2019, 'Clinical trial accrual at initial course of therapy for cancer and its impact on survival', JNCCN Journal of the National Comprehensive Cancer Network, vol. 17, no. 11, pp. 1309-1316. https://doi.org/10.6004/jnccn.2019.7321
Clinical trial accrual at initial course of therapy for cancer and its impact on survival. / Zaorsky, Nicholas G.; Zhang, Ying; Walter, Vonn; Tchelebi, Leila T.; Chinchilli, Vernon M.; Gusani, Niraj J.
In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 17, No. 11, 01.01.2019, p. 1309-1316.
T1 - Clinical trial accrual at initial course of therapy for cancer and its impact on survival
AU - Zaorsky, Nicholas G.
AU - Zhang, Ying
AU - Walter, Vonn
AU - Tchelebi, Leila T.
AU - Chinchilli, Vernon M.
AU - Gusani, Niraj J.
N2 - Background: This retrospective cohort study sought to characterize the accrual of patients with cancer into clinical trials at the time of diagnosis and analyze the impact of accrual on survival. Methods: The National Cancer Database (NCDB) was queried for patients enrolled in clinical trials at their initial course of treatment for 46 cancers from 2004 through 2015. Descriptive statistics were used to characterize the accrual of patients with cancer in clinical trials at diagnosis, and Kaplan-Meier graphical displays, log-rank tests, odds ratios, and stratified Cox proportional hazards models were used to analyze the impact of accrual on overall survival (OS). Strata were defined using 10 variables. Model-based adjusted survival curves of 2 groups were reverse-generated based on a Weibull distribution. Results: Of 12,097,681 patients in the NCDB, 11,576 (0.1%) were enrolled in trials. Patients in clinical trials typically had metastatic disease (30.9% vs 16.4%; P,.0001), were white (88.0% vs 84.8%; P,.0001), had private/managed care insurance (56.4% vs 41.8%; P,.0001), had fewer comorbidities (Charlson-Deyo score 0: 81.9% vs 75.7%; P,.0001, and Charlson-Deyo scores 1-3: 18.1% vs 24.3%; P,.0001) compared with those not in trials. At a median follow-up of 64 months, enrollment in a clinical trial was associated with improved OS in univariate and stratified analyses, with a median survival of 60.0 versus 52.5 months (hazard ratio, 0.876; 95% CI, 0.845-0.907; P,.0001). Stratified analysis with matched baseline characteristics between patients enrolled and not enrolled in a clinical trial showed superior OS at 5 years (95.0% vs 90.2%; P,.0001). Conclusions: Enrollment in clinical trials at first line of therapy in the United States is exceedingly low and favors young, healthy, white patients with metastatic disease and private insurance who are treated at academic medical centers. Patients with cancer treated in clinical trials live longer than those not treated in trials.
AB - Background: This retrospective cohort study sought to characterize the accrual of patients with cancer into clinical trials at the time of diagnosis and analyze the impact of accrual on survival. Methods: The National Cancer Database (NCDB) was queried for patients enrolled in clinical trials at their initial course of treatment for 46 cancers from 2004 through 2015. Descriptive statistics were used to characterize the accrual of patients with cancer in clinical trials at diagnosis, and Kaplan-Meier graphical displays, log-rank tests, odds ratios, and stratified Cox proportional hazards models were used to analyze the impact of accrual on overall survival (OS). Strata were defined using 10 variables. Model-based adjusted survival curves of 2 groups were reverse-generated based on a Weibull distribution. Results: Of 12,097,681 patients in the NCDB, 11,576 (0.1%) were enrolled in trials. Patients in clinical trials typically had metastatic disease (30.9% vs 16.4%; P,.0001), were white (88.0% vs 84.8%; P,.0001), had private/managed care insurance (56.4% vs 41.8%; P,.0001), had fewer comorbidities (Charlson-Deyo score 0: 81.9% vs 75.7%; P,.0001, and Charlson-Deyo scores 1-3: 18.1% vs 24.3%; P,.0001) compared with those not in trials. At a median follow-up of 64 months, enrollment in a clinical trial was associated with improved OS in univariate and stratified analyses, with a median survival of 60.0 versus 52.5 months (hazard ratio, 0.876; 95% CI, 0.845-0.907; P,.0001). Stratified analysis with matched baseline characteristics between patients enrolled and not enrolled in a clinical trial showed superior OS at 5 years (95.0% vs 90.2%; P,.0001). Conclusions: Enrollment in clinical trials at first line of therapy in the United States is exceedingly low and favors young, healthy, white patients with metastatic disease and private insurance who are treated at academic medical centers. Patients with cancer treated in clinical trials live longer than those not treated in trials.
U2 - 10.6004/jnccn.2019.7321
DO - 10.6004/jnccn.2019.7321
JO - Journal of the National Comprehensive Cancer Network : JNCCN
JF - Journal of the National Comprehensive Cancer Network : JNCCN
Zaorsky NG, Zhang Y, Walter V, Tchelebi LT, Chinchilli VM, Gusani NJ. Clinical trial accrual at initial course of therapy for cancer and its impact on survival. JNCCN Journal of the National Comprehensive Cancer Network. 2019 Jan 1;17(11):1309-1316. https://doi.org/10.6004/jnccn.2019.7321
10.6004/jnccn.2019.7321


good comeback records, but 'Stay Steel' sees the band finding their stride. This album has it all: scorching riffs, hummable melodies and a rhythm section that kills. And vocalist Tony Mills – yes that Tony Mills of Shy and TNT – is in impeccable form. Crying Steel is more metal than Mills' previous groups ever were, with the likes of 'Barricades', the Accept-like 'Crank It Up', the Dokken-esque 'Warriors' and the heavy as hell 'Speed Of Light' being totally in your face. Every track, thanks in part to a stellar production, shines. I'd suggest you check out 'Stay Steel' ASAP, and if you like what you hear (you will), then work backwards and pick up their entire catalogue!


Sea Shepherd Conservation Society recently informed Captain Pete Bethune that he will no longer be associated with the society or with any Sea Shepherd campaigns.
The reason is simple. Perhaps in a misguided attempt to gain leniency while still in custody, Bethune provided false testimony to the Japanese authorities regarding Captain Paul Watson. This resulted in an alleged warrant issued for Captain Watson within Japan and the placement of Captain Watson's name on the Interpol Blue List.
It has been reported that a warrant may have been issued in Japan for the arrest of Captain Watson, although neither Captain Watson nor Sea Shepherd has been formally notified by the Japanese authorities that this is so.
This "warrant" was brought to our attention because of a conversation with the Japanese police and Scott West, Sea Shepherd's Director for Investigations, who is on the ground in Taiji, Japan to document the annual dolphin slaughter.
We have now officially requested information from Japan as to the authenticity of such a warrant. We are still awaiting a reply.
The Blue List is not an arrest warrant. It is set up for international border authorities to pass on information to the Japanese police about a person's movements and is arguably designed to inconvenience the named individual when travelling internationally.
Captain Watson was ultimately released without any consequences, but this incident confirms that Japan is escalating the pressure in an attempt to stop Sea Shepherd's annual interventions against Japan's illegal whaling activities in the Southern Ocean Whale Sanctuary.
Why is this all happening this year and not in previous years?
The answer, unfortunately, is the arrest of Bethune in Japan in February of this year.
Bethune's Japanese legal team (to whom Sea Shepherd paid over a half a million dollars to defend Bethune), supplied Sea Shepherd with a transcript of statements made by Bethune to the Japanese prosecutor, wherein Bethune falsely accused Captain Watson of ordering him to board the Shonan Maru #2.
Captain Watson was understandably shocked and deeply disappointed when he read it.
In January 2010, Captain Watson specifically advised Bethune to return to New Zealand after the ramming and sinking of the Ady Gil. Bethune begged Captain Watson to take him back to sea to confront the captain of the Shonan Maru #2.
As documented on camera for the Animal Planet TV show Whale Wars, Captain Watson told Bethune that he could not order him or even ask him to board the Shonan Maru #2. Bethune told Captain Watson he wanted to be taken back to Japan and requested that Sea Shepherd not take him back onboard even if the Japanese whalers offered to return him. He told Captain Watson that someone needed to make a statement and he was prepared to do so; he was prepared to go to prison in Japan if that was what it would take. Captain Watson told Bethune that such a decision had to be Bethune's and Bethune's alone. Bethune agreed, and he also agreed to accept full responsibility for the action.
Only with Bethune's word that the boarding would be Bethune's decision and his decision alone, was Captain Watson comfortable in cooperating with his request.
Unfortunately, Bethune betrayed Captain Watson in an attempt to secure leniency on his sentence.
25 On the Steve Irwin, Paul Watson was on board.
it would be better to speak to the captain of the Shonan Maru No. 2 face to face.
that I began to prepare for the break in.
More specifically, I prepared equipment I would wear, prepared a Jet Ski for the transportation to the Shonan Maru No. 2, and selected a crewmember who would operate the Jet Ski, among other matters.
As to the crew, because Paul Watson asked me whom I would like to have, it was I who selected trustable individuals.
After I climbed up to the deck of the upper part of the bridge, I radioed the bridge of the Steve Irwin.
Paul is saying "well done".
Why don't you go board the Shonan Maru No. 2?
Hearing that, I agreed to that proposal.
3 At the beginning, Paul Watson said: Why don't you go on board and say you will 'citizen-arrest' the captain of the Shonan Maru No. 2?
Later on, as discussions continued, it was decided to make additional demands in addition to the citizen-arrest.
One of them was to demand that a total of 6 sailors from the sunken Ady Gil be taken on board the Shonan Maru No. 2 and transported to New Zealand or a port the Shonan Maru No. 2 was to call next.
It was also decided to demand compensation for the Ady Gil.
Additionally, it was decided that obtaining the name of the captain of the Shonan Maru No. 2 was part of the purpose of the boarding so as to pursue the captain's legal responsibility for the collision in the future.
4 These discussions were conducted mainly between Paul Watson and myself by telephone and E-mail because I stayed on board the Bob Barker [?] for a while after the sinking of the Ady Gil, but Paul Watson was on board the Steve Irwin.
because for Sea Shepherd activities, it was a customary rule that the operator of a rubber boat was in the position of the commander and that other crewmembers were to act according to the operator's command.
However, in this instance, the operator of the rubber boat was acting under the instructions he was receiving from the Steven Irwin by radio.
For this reason, I can generally say that I was acting according to the instructions of Paul Watson, the captain of the Steve Irwin.
3 Incidentally, Paul Watson is not a type of person who would give concrete and detailed instructions such as: "Aim at such and such area of the Shonan Maru No. 2" and I believe those things were decided by the operator of the rubber boat in his discretion.
Make a sortie in a rubber boat and try to prevent the Shonan Maru No. 2 and the Yushin Maru No. 3 from coming close to the stern of the Steve Irwin.
A helicopter was scheduled to take off from the Steven Irwin the next day, but because the Shonan Maru No. 2 and the Yushin Maru No. 3 were anticipated to intercept it, Paul Watson gave such instruction.
There were approximately 10 people then and there, including bridge members and Animal Planet members, besides myself and Paul Watson.
3 The launcher I used at that time is what had been fabricated sometime in September of last year or thereabouts following Paul Watson's instruction to prepare one.
Take the launcher with you and make a sortie in the rubber boat, and thwart their water spraying on the helicopter.
Based on which, I boarded the rubber boat and left the Steve Irwin.
In addition to myself, there were other members assigned to the roles of an operator, a navigator, a cameraman etc., but I cannot state their names.
Transferred from the Steve Irwin to the rubber boat with us on board were the launcher and a box which contained several bottles containing butyric acid.
Seeing them, I understood that firing the bottles containing butyric acid at the Japanese ships was Paul Watson's instruction.
2 This launcher is what I asked Sea Shepherd members to make when I was instructed by Paul Watson to prepare.
The time when I received this instruction from Paul Watson was in July of last year when Paul Watson, myself and others, totaling about 6 persons, got together and had a meeting.
I do not recall the exact word Paul Watson used, but I understood that I was to prepare a "potato launcher.
I do not recall for sure whether Paul Watson expressly said that it would be used for the campaign at the Antarctic Ocean, but because the instruction was given during this meeting, I understood that of course it would be used for the campaign at the Antarctic Ocean.
Regarding the butyric acid next, my thoughts were that it would certainly splash more widely than flying pieces of broken bottles and that the droplets might reach some people in the surrounding area, but I never thought butyric acid would cause any bodily injury.
One of the reasons is that Paul Watson had said butyric acid was harmless to human bodies.
The letter addressed to Kyodo Senpaku Company, Ltd. was written by Paul Watson and 2 Sea Shepherd members.
Because of Bethune's testimony, which contains false statements, Sea Shepherd must publicly disassociate itself from any further involvement with Bethune.
Captain Watson requested that Pete Bethune withdraw quietly so as to not create a drama over this. Bethune replied with a message that was a blatant attempt to use this controversy to try to force Sea Shepherd to give him everything he wanted. Bethune's allegations are bogus, and Sea Shepherd has no problem refuting them.
It is understandable that Bethune is bitter over Sea Shepherd's decision to break ties with him, but Captain Watson had no choice. Bethune was allegedly in communication with the office of the Japanese prosecutor only a few weeks ago and did not let anyone know until now. We have no idea what information was being exchanged or whether any of it was true, but we do know that the transcript of Pete's statement is the basis for the case being built up against Captain Watson, and that is enough to necessitate breaking all ties with Bethune moving forward.
Captain Watson has devoted his life to defending whales, dolphins, and the diversity of life in our seas. During that time, he has never injured a single person, nor has any crewmember sustained a serious injury or been lost. He has also never been convicted of a felony crime, nor have he or Sea Shepherd ever been sued in court by the criminal operations we oppose.
Unfortunately, the government of Japan has now decided to escalate its defense of its illegal whaling operations. Japan is seeking any legal foothold it can get to silence Captain Watson, and Bethune has given them that foothold with his false testimony.
Sea Shepherd is not a covert organization. Everything we do, we do openly. We are careful to work within the law to uphold the law, and in relation to our activities in the Southern Ocean, we have not been charged by the Japanese government for any crime.
Bethune was aware that by boarding the Shonan Maru #2 he would risk arrest by the Japanese authorities. He boarded the vessel with the full understanding that the boarding decision was his own and that he was not following any orders or requests by the Captain or officers of any Sea Shepherd vessel. By giving the Japanese Coast Guard and police a signed statement claiming that Captain Watson had specifically ordered him to board the Shonan Maru #2, Bethune improperly implicated Captain Watson in his action.
Bethune committed a courageous act by boarding the Shonan Maru #2 to confront the captain who had destroyed his ship, the Ady Gil. We appreciate that he brought attention to illegal Japanese whaling in Japan and throughout the world. We appreciate that he was under considerable stress and pressure while in Japanese custody. However, we cannot accept that he gave false testimony to the Japanese authorities that resulted in the placement of Captain Watson on the Interpol Blue List and (according to the police in Taiji) resulted in an arrest warrant for Captain Watson.
It is for this reason that Sea Shepherd must take the necessary step of permanently cutting all ties with Pete Bethune.
The entire situation is regrettable. Sea Shepherd did not wish to make a public drama of this, but it was a choice between our going public or giving in to Bethune's demands. We will not be extorted or told how to conduct our campaigns or who will participate.
In response to Bethune's threats, Captain Watson contacted The Age and the Sydney Morning Herald in Australia and turned over the correspondence and Sea Shepherd's position on the matter. Reporter Andrew Darby, in researching the story, contacted Pete Bethune. We gave Darby his number, and Bethune had his say. Darby's phone call, however, alerted Bethune that we were calling his bluff, and he then promptly began to release his false accusations on Facebook.
Pete Bethune has his own fan base and for those who believe that he is the Whale Warrior he claims to be, all we can say is, by all means, do support him. It was not Sea Shepherd's wish to denigrate him; we wished merely to disassociate ourselves from him and to do so quietly.
If people wish to support Bethune and fund him to go to the Southern Ocean to intervene against the Japanese whaling fleet, we can only say, the more interventions by anyone, the better. He is free to do what he wants to do within his own rules.
But we cannot allow him to return as a Sea Shepherd crewmember and continue to ignore our rules of engagement, and that means, among other things, no weapons and no derogatory references to the Japanese people.
We also cannot abide Bethune's betrayal, his cooperation with the Japanese authorities. If people think he was justified in making false statements to gain leniency, they are free to think so, but when Pete referred to us as being morally bankrupt, I can't think of anything that falls under that definition more accurately than selling out your comrades with false testimony and then attempting to use false information for your own gain.
Sea Shepherd is in the final stages of preparations to return to the Southern Ocean Whale Sanctuary. We intend to impact the whaling operations more so than last season, where we succeeded in cutting the whaling fleet's self-imposed kill quota by over 50%. Every year we get stronger and gain additional resources. This year, we will return stronger than ever, and Captain Watson is confident that we will have a highly effective campaign.
Find more from Sea Shepherd Conservation Society on InfoPages.


Apple TV 4K review – Thumbs Up!
New video from IBM shows how the company embraced mobility to enable a smarter, more productive workforce. This video compliments interviews from IBM CIO Jeanette Horan from earlier this year that states that over 80,000 employees are using BYOD mobile devices to work.


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text:
THE ULTIMATE PRE-CODE MOVIE
Leonard Maltin December 11, 2019
If there hadn't been a Production Code crackdown brewing in Hollywood before The Story of Temple Drake (1933), this astonishing film might have tipped the scales. Based on William Faulkner's sensational novel Sanctuary, it's the story of a carefree Southern belle who teases men—until she is raped and turned into a sex slave. The Criterion Collection's new Blu-ray release provides everything you need to appreciate the unprecedented nature of this material and how potent it remains today.
I'm posting two pieces from 1933 that should be of interest: a publicity piece about Jack La Rue, who plays the notorious Trigger (named Popeye in the novel) and the first paragraphs of a review in the trade journal Motion Picture Herald.
Miriam Hopkins is excellent in the leading role. She gets belated and welcome recognition from Imogen Sara Smith in a first-rate interview on the disc. Film critic Mick LaSalle (author of Complicated Women and Dangerous Men) offers historical context and reminds us that "pre-Code" is not a genre but a time frame. And critic Geoffrey O'Brien adds lucid thoughts in a fine essay in the accompanying booklet.
Finally, master cinematographer and historian John Bailey chats with Matt Severson, director of the Academy of Motion Picture Arts and Sciences' Margaret Herrick Library. As they talk they examine an extraordinary collection of concept art created for Temple Drake by artist and future director Jean Negulesco. These striking German expressionist-inspired images are worth the price of the disc all by themselves. They represent a remarkable blueprint for the film's director, the little-known Stephen Roberts, and his brilliant cinematographer Karl Struss. Struss' work is properly celebrated here and makes me long for a high-quality Blu-ray of Dr. Jekyll and Mr. Hyde which pairs Miriam Hopkins with Fredric March.
The Story of Temple Drake was difficult to see for many years. What's more, a crummy print could obliterate the beauty of Struss's use of light and shadows. When author/historian David Stenn tried to license footage from the film to use in his documentary Girl 27 Paramount said it didn't own the rights. So did Fox, which released the remake Sanctuary. He finally spoke to the late Richard Zanuck, who ran 20th Century Fox in the 1960s. Zanuck confirmed that he had purchased the negative from Paramount along with the Faulkner book in order to make the 1961 adaptation. That cleared the way for a screening of Temple Drake at the TCM Classic Film Festival (where the Museum of Modern Art's gorgeous 35mm print was shown) and this Criterion release.
Tagged Complicated Women and Dangerous MenDavid StennDr. Jekyll and Mr. HydeFredric MarchGeoffrey O'BrienGirl 27Jack La RueJean NegulescoJohn BaileyKarl StrussMargaret Herrick LibraryMatt SeversonMick LaSalleMiriam HopkinsMotion Picture HeraldProduction CodeRichard ZanuckSanctuaryStephen RobertsThe Criterion CollectionThe Story of Temple DrakeWilliam Faulkner

redpajama_set_name: RedPajamaCommonCrawl


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text:
Bad Girls Club
Angelica Risper
The American Reality Television show Bad girls club, created by Jonathan Murray, has been on for 16 seasons. The show was originally released on December 5, 2006, and is still on until this day. The reality show takes place in different cities each season. The show focuses on the altercations and the very physical fights between the eight girls. The eight girls are very aggressive, confrontational, and wild women. Each of the women tend to have psychological and behavioral problems.
All of the eight woman come from different backgrounds and have different personalities. The show picks eight women from different cities and states, age range from 21-31. The woman are brought together to live in a big luxurious mansion for three months, and they have to follow very simple rules. If a cast member violates production rules, she is evicted from the show and, if it is early in the season, replaced by a new cast member.
Basically, they have to just last until the final episode without being kicked off. That can also be extremely hard, when you're living with females that also think they're the"baddest chick" and plus you have never met before.
I recommend this show for anyone who likes violence and like seeing people getting into fights on camera. This show is rated R, so make sure you ask your parents for permission. I give this reality show a 4/5 of the fact it is very entertaining but, at times it can really get repetitive.
The War Hammer Titan
Dulce Mami Cafe
CTU vs CPS Returning to School
The 92nd Academy Awards
Tres Campanitas
Eminem's new songs
3DTuning, Creating your own car


Astri Suhrke has a PhD in international relations and is a senior researcher at the Chr. Michelsen Institute in Bergen, Norway. She has written widely on the nature and consequences of social conflict, the politics of humanitarian policies and, most recently, peacebuilding. She has followed developments in Afghanistan since the early 1980s.


text:
Q: Perl: size of array in a hash, in another hash So, I have a hash %HoHoA.
Each top level hash key has a second level hash key as a value.
Each second level hash has arrays-of-arrays as values.
In perl's debugger it looks something like this:
0 'Top_key_1'
1 HASH(0x...)
  'Second_Key_1' => ARRAY(0x...)
    0   'string 1'
    1   'string 2'
  'Second_Key_2' => ARRAY(0x...)
    0  ARRAY(0x...)
      0 'string 3'
      1 'string 4'
      2 'string 5'
    1  ARRAY(0x...)
      0 'string 6'
      1 'string 7'
2 'Top_key_2'

I'm trying to get the size of each suite's two arrays. In the above
example, Second_Key_2 has two arrays, the 0th one is size 3.
my $count1 = $#{$HoHoA{$top_key}{$second_key}[0]}+1;
my $count2 = $#{$HoHoA{$top_key}{$second_key}[1]}+1;

and
my $count1 = @{$HoHoA{$group}{$suite}[0]};
my $count2 = @{$HoHoA{$group}{$suite}[1]};

I get an error message like:
Can't use string ("string 3") as an ARRAY ref while "strict refs" in use
Why am I getting that error message, and what should I do instead?

A: $HoHoA{$group}{$suite}[0] isn't an arrayref; it's a string, thus the error. Maybe you need to debug the code that's building your data structure.

A: Run it under the debugger and recursively dump out a data structure, or point therein, with the x command.
You can do that programmatically with the Dumpvalue module, but it's much less convenient.
I wish people wouldn't keep thinking I wrote perllol as a joke. ☺

A: It look like you went one level too deep.
The code below should get you what you want
my $count1 = @{$HoHoA{$group}{$suite}};

You may also may want to use Data::Dumper to see the
Structure of your object to ensure you are working on the write data format.
use Data::Dumper;
print Dumper($HoHoA);

redpajama_set_name: RedPajamaStackExchange


Quilts, Macys Quilts King was posted March 1, 2017 at 1:07 am by esprit-public.info . More over Macys Quilts King has viewed by 2955 visitor.
Quilts, Macys Quilts Clearance was posted September 13, 2016 at 6:51 am by esprit-public.info . More over Macys Quilts Clearance has viewed by 3509 visitor.
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All industries are becoming heavily automated, processing large amounts of data to predict market trends. Machine learning, network optimisation, semantic search and many more technological advances are the result of data analytics.
There is an entire ocean of data across almost all verticals ready to be exploited by companies that are smart enough to recognise its potential. Companies see the biggest potential for value creation through better data management and automation, mainly bound to efficiency aspects.
big data to boost productivity and create value.
Most companies characterise big data as too large to process with conventional software systems and databases. They still don't have the comprehensive strategies and technical skills to make the most of their vast pools of information.


text:
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Researchers receive $2.3M in NSF grants to investigate how robots can be used to provide personalized healthcare
San Diego, Calif., Nov. 6, 2019--Computer science professor Laurel Riek is the lead researcher on $2.3 million in new grants from the National Science Foundation to investigate how intelligent, personalized robots can be used to support neurorehabilitation for adults with mild cognitive impairment and adults recuperating from a stroke.
Riek directs the Healthcare Robotics Lab at the University of California San Diego, focusing on human-robot teaming, computer vision and healthcare engineering. Her team works on building systems able to sense, learn from, and adapt to people. Her research has applications in safety-critical, uncertain environments, including hospitals, homes, and work sites.
Researchers will be using this Kuri robot for the TAILORED grant.
Riek received a $1.2 million NSF grant, titled "TAILORED: Training for Independent Living through Observant Robots and Design", in collaboration with UC San Diego clinical psychologist Elizabeth Twamley and computer scientist Kamalika Chadudhuri to create human-centered robotics technology that will provide personalized neurorehablititation for older adults with mild cognitive impairment. The condition, which affects 16 million people in the United States, is characterized by cognitive functioning difficulties, for example struggling with problem solving, scheduling, and medication management.
"Harnessing technology to provide cognitive support and rehabilitation for older adults could potentially assist millions of people to maintain or improve their functioning and quality of life, and maintain their ability to live independently," the researchers wrote.
The team will pioneer innovative methods to deliver and sustain neurorehabilitation; create new approaches to support long-term robot learning in real-world environments; and contribute new methods to the fields of human-robot interaction, aging science, and behavioral science.
An illustration of how a combination of neuroscience, robotics, and machine learning research will intersect on the HEBB grant.
Riek also received another new grant, "HEBB: Human-Robot Enabled System to Induce Brain Behavior Adaptations", in collaboration with researchers at UC Davis, part of a $1.1 million grant from NSF. The project explores ways to create new intelligent technologies to support people who have had strokes--which number about 800,000 each year in the United States.
"The objective of this [project] is to create an embodied, intelligent robotic system that provides personalized, adaptive feedback to induce neuromotor plasticity, mediate motor adaptation, and leverage meaningful, lasting changes in motor function," the researchers wrote.
The team will determine performance feedback to optimize motor learning and the capacity for neuroplasticity to promote meaningful behavioral change. This collective information, combined with machine learning, will be used to personalize the interactions necessary to maximize motor behavioral changes.
In addition to her appointment in the Department of Computer Science and Engineering, Riek also holds an appointment in the Department of Emergency Medicine at UC San Diego.
Ioana Patringenaru
Jacobs School of Engineering
ipatrin@ucsd.edu
Healthcare Robotics Lab »
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text:
Dad: One Year Later
For what is your life? It is even as
a vapor which appears for a little while
but then vanishes away.
The Bible, in its logical and honest way, portrays life as something like a vapor or mist, which is visible for a little while, but then it's gone. And isn't it true? Life is brief...
Our time on earth, when compared with eternity, is as a grain of sand on the seashore.
But also true is that our lives, if lived wisely, can be like the fragrance of a flower, something which casts a sweet aroma that may linger long after we're gone. Such is the case with my father. As today marks one year since he passed away at the age of 101.
One year later and my tears continue to flow. You see, my Dad was a very special person. Friendly, kindhearted and easygoing, many sought his wisdom and advice. He was a hard worker, too, and a dedicated family man who did his best to provide for his wife, and his only child, me.
Like most fathers, his dream was to see me finish school, get married, raise my own family and live a good life. And he hoped as well to be a proud grandfather one day. He longed for the joy of having a bunch of grandkids at his feet, taking them out for ice cream the way he often did with me. But life isn't always so serene and simple.
Unfortunately for my father and me, I was to experience many years of emotional turbulence along with a host of other adolescent-type struggles. I battled depression. I was a stubborn and rebellious child. I was distant and remote, as well, and my strange behaviors caused him much grief. It affected my mother in the same way. Inexplicably I would spurn their love causing my parents to shed many tears. This was my self-destructive nature at work.
Then, when I was arrested at the age of twenty-four, my father was devastated and heartbroken. What had happened to his beloved son, he wanted to know. It was all so senseless. For my father, it was a nightmare.
Yet my Dad never stopped loving me or believing in me. He never rejected or disowned me for my crimes, or for ruining so many lives including my own. He was a true encourager who stuck with me until the end.
Frankly my Dad, as a Jew, could teach many Christians about true forgiveness by the way he lived, even by the way he continued to treat me. From the outset he found it in his heart to forgive me, a son who brought him much public shame. And my Dad never allowed bitterness or unforgiveness to poison his spirit. He held no grudges toward me and he demonstrated lots of compassion. All told, I'm a blessed man. "I love you, Dad.
I miss you very much!"
D. B.


Limited edition LP includes album download voucher with bonus mixtape tracks hosted by Brother May.
Chopped & Screwed is the collaboration between London based musician Mica Levi aka Micachu and the London Sinfonietta Orchestra. Following critical acclaim for Micachu and the Shapes's debut album Jewellery, the collaboration came about as the Sinfonietta had picked up on the fact that Mica is a trained classical composer who was interested in experimenting with new forms, and was someone whose ideas would meld well with the avant-garde philosophy of the Sinfonietta itself. The sound blends the organic,the digital and the analogue with instruments such as homemade guitars and a vacuum cleaner.
Chopped & Screwed was recorded live at King's Place on May 10, 2010 a recently built and specially designed venue, treated to showcase the best in classical and acoustic music in London.
The concept behind the album was inspired by the popular "chopping and screwing" technique in hip-hop which was developed in Houston in the 1990s. The technique involves halving tempo, skipping beats and affecting portions of the original music. The approach was thought to have been developed by DJ Screw and largely influenced by Purple Drank, a codeine-based cough syrup which creates the effect of slowing down the brain, giving mellow music its appeal.


Moon is a system of reading and writing which uses tactile symbols based on lines and curves to represent letters, numbers and punctuation marks.
It is easier to learn than braille, as the letters are easier to distinguish by touch. However, Moon cannot be written by hand, is even bulkier than braille and currently there is very little literature available in Moon.
Moon is used by a very small number of people, most of whom are elderly.
As it is unlikely that you will receive requests for Moon you do not need to produce materials in Moon as a matter of course. If you receive a request for Moon, ask whether another format, such as audiotape, would be a usable alternative. If Moon is required, contact the RNIB for guidance.


Ezugi is a live dealer game provider with a track record in delivering high-quality interactive gaming services to online casinos worldwide. With its own video streaming technology, spacious studios, highly professional and friendly live dealers, the company delivers real time content to casino players making their gaming experience closer to the land-based one.
Games by Ezugi have multi-player and multi-seat functionality. They are also enhanced by quite a number of add-on features which make the gameplay more exciting. Opportunity to view the game history, leave tips to the favourite dealer, see other game videos as "picture in picture" and add live music on demand – all of that contributes to the realistic feeling of playing at a land-based casino and being part of the gaming community.
Ezugi also has social features integrated into the platform, so players can invite their friends to join the game or even share their joy of victory with others by simple clicking on one of the social network buttons. This produces a viral effect and helps casino operators in creating a more successful client acquisition and retention strategy.


The world's population is increasing and the environmental crisis generated by the degradation of natural resources demands a new development paradigm; this should include a new vision and innovation to generate alternatives and solutions to achieve a more sustainable development. The challenge of a sustainable world requires, besides knowledge, creativity and a holistic perspective to realize the conservation and best possible use of natural resources. We mycorrhizologists ought to take up this challenge and contribute to the preservation and careful management of resources, generating knowledge that is not only novel but also connected to the goals of sustainability and human well-being.
In ICOM 10 we wish to encourage innovation in the researchers, students, companies and organizations that study mycorrhizal symbiosis in order to generate basic and applied knowledge in a different way; a way committed to sustainable development. We wish to invite the young, the creative, the critical, the skeptical, and the innovative to the stage, in our search for alternative paths to facing this great challenge. This is why we are inviting you all to Mexico, to Merida, in the heart of ancestral Mayan culture; a culture with an astounding development of abstract knowledge and knowledge of nature.


Since 1889, when Mrs. Elizabeth Hayne, her husband, Roger, and their friend, Dr. Edward Saunders, created what is known today as Bethesda Health Group, our organizational goals have included caring for our community and meeting the needs of those who can benefit from our services.
At Bethesda, we strive every day to foster successful aging through compassion and innovation. It's our Vision Statement, and it exemplifies the commitment of our employees and our volunteers toward our residents, their families and the St. Louis community.
We pride ourselves in engaging in partnerships and activities that benefit the St. Louis community. Whether we're participating or sponsoring a community activity, or providing counseling and support, we at Bethesda take our role as a community leader quite seriously.
Bethesda's social responsibility wouldn't be complete without the Bethesda Health Group Foundation and the provision of humanitarian care. In keeping with our charitable commitment, Bethesda has provided millions of dollars ($14 million in 2016) to those seniors who have outlived their assets and are unable to pay for the full cost of care they receive from us.
Thanks to the efforts of the Foundation staff, and the generosity of the Bethesda employees, volunteers and the residents and their families and friends, our residents will always have a home with Bethesda.
Bethesda continues to be part of the St. Louis "Meals on Wheels" program. Volunteers gather at Bethesda Dilworth and Bethesda Southgate, and coordinate meal delivery to the needy throughout the community. Annually, Bethesda staff and volunteers help account for the distribution of more than 20,000 meals.
Between candle lighting and pinning ceremonies coordinated through Bethesda Hospice Care for Veterans who live in our own communities, and our active involvement with Jefferson Barracks and the St. Louis Honor Flights to Washington D.C., Bethesda recognizes and honors those who served our country.
We also offer free Veterans Support Groups, which are open to the general community as well as to our residents and their families. Facilitated by trained Bethesda staff members, these groups meet at various Bethesda communities, and provide comfort and support for all who attend.
For the past four years, Bethesda's Veterans – residents and volunteers – have served as "educators" as part of the Lindbergh High School "History Alive" program. Their participation helps hundreds of high school students annually learn about World War II and the Korean and Vietnam wars by seeing and hearing first-hand what it was like to have served.
Imagine seeing nearly 200 people walking in a sea of orange through downtown St. Louis on a crisp September morning. For the Bethesda employees, volunteers and residents who attended the 2015 Walk to End Alzheimer's, imagination isn't necessary. Their participation raised $10,362.73 to help support a community partner that shares our mission of caring for seniors and their families.
The local chapter of the Alzheimer's Association is just one of the many organizations with which Bethesda partners. We host support groups (American Parkinson's Disease Association, Huntington's Disease Society), and annually support fundraising events (St. Louis Society for the Blind and Visually Impaired). And our employees, including the majority of our Senior Management, will even dump water on their heads (ALS – the Ice Bucket Challenge) for a worthwhile cause.


text:
The Lumberjack, January 21, 2010.
2 The Lumberjack | Jackcentral.com
InTheNews
BY JILL HALLQUIST • THE LUMBERJACK
CrimeLog
At 12:30 a.m., an officer observed a vehicle turn right without coming to a complete stop at a stop sign at the intersection of Pine Knoll Drive and McConnell Drive.
The officer proceeded to follow the vehicle and noted the driver-side tires crossed the double yellow line twice before reaching the intersection of Knoles Drive and McConnell Drive. The officer initiated a traffic stop.
The officer asked the driver for his license, registration and proof of insurance. The driver gave the officer his California driver's license and told the officer his insurance card was being mailed to him. The officer identified the driver as an 18-year-old male. The officer asked the subject if he had been drinking, and the subject told the officer he had not had anything to drink. The officer asked the subject to exit the vehicle and asked again if he had been drinking. The subject proceeded to tell the officer he had not been drinking that night.
The officer told the subject there was a strong odor of alcohol coming from his breath, and the subject told the officer he had been drinking Captain Morgan and Coke three hours ago. The officer asked the subject to perform field sobriety tests, and the subject complied. An additional officer arrived on scene to question two passengers in the car.
The subject performed the field sobriety tests without showing evidence of intoxication. The officer arrested the subject due to the odor of alcohol coming from his body and for being underage and admitting to consuming alcohol. The subject provided a blood-alcohol breath test, registering a blood alcohol content of .106 percent.
Both passengers received citations for minor consumption of alcohol. The driver also received a citation for minor driving under the influence and driving in violation of a driver's license restriction. The car was impounded.
The case is closed.
At 8:47 p.m., a resident of McConnell Hall requested medical assistance because she had been feeling ill for the past two days.
An officer and medics were dispatched to the scene. The resident was transported to Flagstaff Medical Center for evaluation.
No further information is available at this time.
At 1:42 a.m., staff at Tinsley Hall called to report an intoxicated subject attempting to enter residences on multiple floors inside the building.
Two officers were dispatched to the scene. One subject was arrested and booked into Coconino County Jail for trespassing and aggravated assault on a police officer.
No further information is available at this time.
At 5:51 p.m., a subject called to report a fight near the bookstore on campus.
Two officers were dispatched to the scene. One subject was booked into Coconino County Jail for three warrants and minor consumption of alcohol. An additional subject was booked into Coconino County Jail for minor consumption of alcohol.
At 10:54 p.m., a resident at McDonald Hall called to report his roommate had left marijuana and drug paraphernalia lying out in their residence.
Two officers were dispatched to the scene. One subject received a citation for possession of marijuana and drug paraphernalia.
NewsinBrief
Weekend4Cast
SHERIFF ARPAIO
PHOENIX – Two of the top Maricopa County officials testified this past week before a federal grand jury in Phoenix. Officials are investigating whether Sheriff Joe Arpaio abused his power. County Manager David Smith said his appearance in court in front of the grand jury was "... a welcome opportunity to tell our story on behalf of county employees," who said they have been targeted by Arpaio.
ARIZONA GOVERNOR
PHOENIX – Dean Martin, Arizona state treasurer, announced his candidacy for Arizona governor last week. Martin, the former state senator from Phoenix, is challenging incumbent Jan Brewer for the Republican nomination. Martin said his priorities as governor would encompass general tax cuts to help attract businesses to create jobs in the state. Martin is also a major supporter of deploying radar and camera equipment along the Mexico border to crack down on illegal immigration.
Flagstaff police have launched an investigation into the deaths of two giraffes formerly from Michael Jackson's Neverland Ranch. The giraffes were likely to join two other giraffes in finding new homes. Freddie and Tom Hancock of Page, Ariz., acquired the giraffes as part of their plan to open a wildlife preserve on city property leased in 2008. The preserve would also house exotic birds, reptiles and a camel. However, those plans fell apart when the Hancocks and the city began a legal battle over the lease's terms for the 175-acre property in southeast Page.
KINDLE-BLIND
WASHINGTON — Three universities are currently testing Amazon's Kindle, a handheld electronic reader, in the classroom and have agreed to shelve the product until it becomes fully functional for the blind, under a deal struck this past week with the Justice Department. The settlements were made with Pace University in New York, Case Western Reserve University in Cleveland, and Reed College in Portland, Ore. The settlement announcement came two days after a very similar deal was made with ASU.
Also note:
TUCSON HAITI AID— Tucson-based World Care said it plans to respond to and help the earthquake victims of Haiti after a magnitude 7 earthquake caused thousands of buildings to collapse in Port-au-Prince, Haiti's capital.
CHILD/GUN TRADE—Authorities in Maricopa County said they have arrested a Mesa woman who tried to trade her 2-year-old daughter for a gun.
DEATH SENTENCE — A man convicted for the 1993 slaying of a former Phoenix newspaper science writer has been sentenced to death.
PUBLIC SAFETY DIRECTOR — Arizona Gov. Jan Brewer announced this past week that Robert Halliday will be the new director for the Arizona Department of Public Safety.
SundayH33° L25°H32° L14°H32° L10°H34° L9°
HEAVY SNOW AND WIND
SNOW AND WIND
State Weather
SOURCE: THE ASSOCIATED PRESS
H63, L51
Tucson H60, L49 H54, L40 H56, L35 H59, L34
Prescott H44, L31 H38, L26 H40, L21 H42, L20
Source: www.weather.com
Title The Lumberjack, January 21, 2010.
Oral history transcripts 2 The Lumberjack | Jackcentral.com InTheNews BY JILL HALLQUIST • THE LUMBERJACK CrimeLog Jan. 10 At 12:30 a.m., an officer observed a vehicle turn right without coming to a complete stop at a stop sign at the intersection of Pine Knoll Drive and McConnell Drive. The officer proceeded to follow the vehicle and noted the driver-side tires crossed the double yellow line twice before reaching the intersection of Knoles Drive and McConnell Drive. The officer initiated a traffic stop. The officer asked the driver for his license, registration and proof of insurance. The driver gave the officer his California driver's license and told the officer his insurance card was being mailed to him. The officer identified the driver as an 18-year-old male. The officer asked the subject if he had been drinking, and the subject told the officer he had not had anything to drink. The officer asked the subject to exit the vehicle and asked again if he had been drinking. The subject proceeded to tell the officer he had not been drinking that night. The officer told the subject there was a strong odor of alcohol coming from his breath, and the subject told the officer he had been drinking Captain Morgan and Coke three hours ago. The officer asked the subject to perform field sobriety tests, and the subject complied. An additional officer arrived on scene to question two passengers in the car. The subject performed the field sobriety tests without showing evidence of intoxication. The officer arrested the subject due to the odor of alcohol coming from his body and for being underage and admitting to consuming alcohol. The subject provided a blood-alcohol breath test, registering a blood alcohol content of .106 percent. Both passengers received citations for minor consumption of alcohol. The driver also received a citation for minor driving under the influence and driving in violation of a driver's license restriction. The car was impounded. The case is closed. Jan. 12 At 8:47 p.m., a resident of McConnell Hall requested medical assistance because she had been feeling ill for the past two days. An officer and medics were dispatched to the scene. The resident was transported to Flagstaff Medical Center for evaluation. No further information is available at this time. Jan. 13 At 1:42 a.m., staff at Tinsley Hall called to report an intoxicated subject attempting to enter residences on multiple floors inside the building. Two officers were dispatched to the scene. One subject was arrested and booked into Coconino County Jail for trespassing and aggravated assault on a police officer. No further information is available at this time. At 5:51 p.m., a subject called to report a fight near the bookstore on campus. Two officers were dispatched to the scene. One subject was booked into Coconino County Jail for three warrants and minor consumption of alcohol. An additional subject was booked into Coconino County Jail for minor consumption of alcohol. No further information is available at this time. At 10:54 p.m., a resident at McDonald Hall called to report his roommate had left marijuana and drug paraphernalia lying out in their residence. Two officers were dispatched to the scene. One subject received a citation for possession of marijuana and drug paraphernalia. The case is closed. NewsinBrief Weekend4Cast SHERIFF ARPAIO PHOENIX – Two of the top Maricopa County officials testified this past week before a federal grand jury in Phoenix. Officials are investigating whether Sheriff Joe Arpaio abused his power. County Manager David Smith said his appearance in court in front of the grand jury was "... a welcome opportunity to tell our story on behalf of county employees," who said they have been targeted by Arpaio. ARIZONA GOVERNOR PHOENIX – Dean Martin, Arizona state treasurer, announced his candidacy for Arizona governor last week. Martin, the former state senator from Phoenix, is challenging incumbent Jan Brewer for the Republican nomination. Martin said his priorities as governor would encompass general tax cuts to help attract businesses to create jobs in the state. Martin is also a major supporter of deploying radar and camera equipment along the Mexico border to crack down on illegal immigration. MICHAEL JACKSON GIRAFFES Flagstaff police have launched an investigation into the deaths of two giraffes formerly from Michael Jackson's Neverland Ranch. The giraffes were likely to join two other giraffes in finding new homes. Freddie and Tom Hancock of Page, Ariz., acquired the giraffes as part of their plan to open a wildlife preserve on city property leased in 2008. The preserve would also house exotic birds, reptiles and a camel. However, those plans fell apart when the Hancocks and the city began a legal battle over the lease's terms for the 175-acre property in southeast Page. KINDLE-BLIND WASHINGTON — Three universities are currently testing Amazon's Kindle, a handheld electronic reader, in the classroom and have agreed to shelve the product until it becomes fully functional for the blind, under a deal struck this past week with the Justice Department. The settlements were made with Pace University in New York, Case Western Reserve University in Cleveland, and Reed College in Portland, Ore. The settlement announcement came two days after a very similar deal was made with ASU. Also note: TUCSON HAITI AID— Tucson-based World Care said it plans to respond to and help the earthquake victims of Haiti after a magnitude 7 earthquake caused thousands of buildings to collapse in Port-au-Prince, Haiti's capital. CHILD/GUN TRADE—Authorities in Maricopa County said they have arrested a Mesa woman who tried to trade her 2-year-old daughter for a gun. DEATH SENTENCE — A man convicted for the 1993 slaying of a former Phoenix newspaper science writer has been sentenced to death. PUBLIC SAFETY DIRECTOR — Arizona Gov. Jan Brewer announced this past week that Robert Halliday will be the new director for the Arizona Department of Public Safety. Thursday Friday Saturday SundayH33° L25°H32° L14°H32° L10°H34° L9° HEAVY SNOW AND WIND SNOW AND WIND MOSTLY CLOUDY PARTLY CLOUDY State Weather SOURCE: THE ASSOCIATED PRESS City Thursday Friday Saturday Sunday Phoenix H63, L51 H57, L44 Tucson H60, L49 H54, L40 H56, L35 H59, L34 Prescott H44, L31 H38, L26 H40, L21 H42, L20 H61, L41 H63, L40 Source: www.weather.com Flagstaff


A dozen years ago, St. Helena was where Napa Valley visitors wanted to stay and to eat, with the town of Napa rarely getting more than a glance from the highway. But for food lovers, the center of gravity in the valley has indisputably shifted south, with most of the creative energy concentrated between Yountville and Napa. Of course, the up-valley towns of Oakville, St. Helena and Calistoga still offer plenty for the culinary traveler, but now you can have a delicious weekend "down valley," too.
Rising from the ashes of NapaStyle, chef Michael Chiarello's defunct home-goods business, Ottimo fuses retail emporium and restaurant into a compelling experience. Hungry visitors will head for the U-shaped bar in the rear for fresh mozzarella (four types) with a choice of condiments or Neapolitan-style fried pizza finished in a wood oven. Acres of Carrara marble blanket the counters and bar-height tables, perhaps one clue to why this project, according to Chiarello, ran a million dollars over budget. Diners stand to eat "like in a train station," says the chef. So make like you're in Milan and chat up the stranger across the table while you toss back a macchiato or grab a prosciutto panino. Afterwards, tour the premises, a sort of foodie amusement park with a hosted tasting area for sampling housemade salumi and blood-orange marmalade; shelves of culinary collectibles like antique cheese graters and ravioli cutters; hand-pounded copperware from Naples and silver flatware from Florence; and exquisite carbon-steel chef's knives from Bhutan. By spring, the restaurant expects to have house-brewed beer on tap with the help of an Italian consultant.
6525 Washington St. (in the V Marketplace), Yountville, (707) 944-0102.


At Shalford Primary every child has a home school diary which hopes to provide a direct exchange of information and dialogue between home and school. We aim to ensure that parents and carers are fully informed about their child's daily activities and wellbeing as well as providing our children with a voice to enable them to communicate their daily activities at home or school. We believe that all children will learn better if home and school work together in partnership. To achieve this aim we ask parents and carers to support and sign our Home School Agreement.


E - Weaver; Corey King. DP - Va. Wesleyan 1. LOB - Eagles 7; Va. Wesleyan 9. 2B - Johnston; B. Kussmaul; Justin Erby. HR - Hague. HBP - Burns; Weaver. SF - Randy Neisz; Deon Hammond. SB - Ruiz 2; Taylor Erby.
Win - Shapiro (1-0). Loss - A. Gammon (1-1). Save - Johnston (2). WP - Johnston; A. Gammon; L. Chiasson. HBP - by A. Gammon (Burns); by L. Chiasson (Weaver). Inherited runners/scored: None. Pitches/strikes: Cross 67/41; Shapiro 73/43; White 11/9; Johnston 19/13; A. Gammon 78/55; L. Chiasson 38/31; Pizzanello 12/4; Tyler Floyd 13/8.
Mary Washington 1st - Burns hit by pitch (2-2 BFKF). Weaver singled to left field (0-0); Burns advanced to second. Hague flied out to rf (0-2 KSF). Johnston doubled down the lf line, RBI (1-0 B); Weaver advanced to third; Burns scored. Bynum struck out swinging (1-2 SFBS). Ruiz singled through the left side, RBI (0-0); Johnston advanced to third; Weaver scored. Ruiz stole second. Lyons struck out swinging (1-2 SBSS). 2 runs, 3 hits, 0 errors, 2 LOB.
Virginia Wesleyan 1st - B. Kussmaul doubled to left center (0-0). Corey King flied out to cf (0-0). Justin Erby singled to center field, advanced to second on the throw, RBI (0-1 K); B. Kussmaul scored. Randy Neisz walked (3-2 BFFBFBFB). Deon Hammond flied out to lf (1-2 FKB). Justin Erby out at third c to 2b to 3b, picked off. 1 run, 2 hits, 0 errors, 1 LOB.
Mary Washington 2nd - Webb singled through the left side (2-2 BKBF). Runey singled through the right side (1-2 KFB); Webb advanced to second. Burns flied out to rf (0-0). Weaver struck out swinging (1-2 BKSS). Hague grounded out to 3b (0-0). 0 runs, 2 hits, 0 errors, 2 LOB.
Virginia Wesleyan 2nd - Taylor Erby singled to right center (0-0). Zack Clark struck out looking (3-2 BBBKSK). J. Sprouse popped up to ss (1-1 BK). Jimmy Ziemke grounded out to p, bunt (0-0). 0 runs, 1 hit, 0 errors, 1 LOB.
Mary Washington 3rd - Johnston struck out swinging (2-2 SBBFFS). Bynum grounded out to ss (2-0 BB). Ruiz struck out swinging, grounded out to c unassisted (0-2 KKS). 0 runs, 0 hits, 0 errors, 0 LOB.
Virginia Wesleyan 3rd - B. Kussmaul walked (3-0 BBBB). Corey King reached on a fielding error by 3b (2-2 BFKFB); B. Kussmaul advanced to second. Justin Erby doubled to left center, RBI (3-2 FFFBBBFF); Corey King advanced to third; B. Kussmaul scored. Randy Neisz flied out to cf to right center, SF, RBI (3-2 KKBBBF); Justin Erby advanced to third; Corey King scored, unearned. Deon Hammond lined out to rf to right center, SF, RBI (0-2 FF); Justin Erby scored, unearned. Taylor Erby walked (3-1 KBBBB). Taylor Erby stole second. Zack Clark struck out swinging (1-2 BKKS). 3 runs, 1 hit, 1 error, 1 LOB.
Mary Washington 4th - Lyons reached on a throwing error by 2b, advanced to second (2-1 BFB). Webb singled to left field (0-2 KK); Lyons advanced to third. Runey walked (3-1 BBKBB); Webb advanced to second; Lyons scored on a wild pitch, unearned. Burns fouled out to 1b (0-1 K). Weaver singled to shortstop (1-1 BK); Runey advanced to second; Webb advanced to third. Hague homered to center field, 4 RBI (3-1 BBSB); Weaver scored; Runey scored; Webb scored. L. Chiasson to p for A. Gammon. Johnston struck out swinging (0-2 KKS). Bynum popped up to 1b (1-1 SB). 5 runs, 3 hits, 1 error, 0 LOB.
Virginia Wesleyan 4th - Shapiro to p for Cross. J. Sprouse struck out swinging (3-2 BBBKSS). Jimmy Ziemke flied out to rf (0-0). B. Kussmaul walked (3-2 SSBBBB). Corey King singled through the left side (1-1 BK); B. Kussmaul advanced to second. Justin Erby reached on a fielder's choice (2-1 BFB); Corey King out at second ss to 2b. 0 runs, 1 hit, 0 errors, 2 LOB.
Mary Washington 5th - Ruiz singled up the middle (0-0). Ruiz stole second. Lyons struck out swinging (1-2 KKFBS). Ruiz advanced to third on a wild pitch. Webb struck out looking (2-2 BSBFFK). Runey flied out to lf (0-0). 0 runs, 1 hit, 0 errors, 1 LOB.
Virginia Wesleyan 5th - Randy Neisz grounded out to 3b (0-2 SKF). Deon Hammond struck out looking (2-2 KBSBK). Taylor Erby struck out looking (3-2 BKBSBFK). 0 runs, 0 hits, 0 errors, 0 LOB.
Mary Washington 6th - Burns grounded out to ss (0-1 F). Weaver hit by pitch (1-0). Hague flied into double play cf to 2b to 1b (1-1 KB); Weaver out on the play. 0 runs, 0 hits, 0 errors, 0 LOB.
Virginia Wesleyan 6th - Zack Clark grounded out to 1b unassisted (2-2 KBBS). J. Sprouse grounded out to ss (2-2 KBBF). Jimmy Ziemke walked (3-0 BBBB). B. Kussmaul grounded out to 3b (2-0 BB). 0 runs, 0 hits, 0 errors, 1 LOB.
Mary Washington 7th - Johnston singled through the right side (0-1 F). Bynum reached on a fielder's choice (1-2 KBF); Johnston out at second ss to 2b. Ruiz grounded out to ss (0-0); Bynum advanced to second. Lyons grounded out to 2b (0-1 F). 0 runs, 1 hit, 0 errors, 1 LOB.
Virginia Wesleyan 7th - Corey King flied out to cf (0-0). Justin Erby walked (3-2 BFFBBB). Randy Neisz flied out to lf (1-0 B). Deon Hammond struck out looking (0-2 KFFFFK). 0 runs, 0 hits, 0 errors, 1 LOB.
Mary Washington 8th - Pizzanello to p for L. Chiasson. Webb flied out to lf (1-0 B). Runey walked (3-1 BBBKB). Burns fouled out to c (1-0 B). Weaver reached on a fielder's choice (2-0 BB); Runey out at second ss to 2b. 0 runs, 0 hits, 0 errors, 1 LOB.
Virginia Wesleyan 8th - White to p for Shapiro. Taylor Erby grounded out to ss (0-2 KF). Nick Ott pinch hit for Zack Clark. Nick Ott struck out looking (1-2 KKBK). Z. Burkhart pinch hit for J. Sprouse. Z. Burkhart struck out swinging (1-2 KKBS). 0 runs, 0 hits, 0 errors, 0 LOB.
Mary Washington 9th - Brady Fallon to 1b for Nick Ott. Z. Burkhart to c. Tyler Floyd to p for Pizzanello. Hague struck out swinging (3-2 KBKBBS). Johnston struck out swinging (2-2 BKBKFS). Bynum grounded out to p (0-0). 0 runs, 0 hits, 0 errors, 0 LOB.
Virginia Wesleyan 9th - Johnston to p. / for White. A. Obenour pinch hit for Jimmy Ziemke. A. Obenour struck out looking (0-2 KSK). B. Kussmaul flied out to rf (0-0). Corey King singled to second base (1-0 B). Justin Erby walked (3-1 BBKBB); Corey King advanced to second. Randy Neisz singled to right field, RBI (0-2 KF); Justin Erby advanced to third; Corey King scored. Deon Hammond singled up the middle, RBI (0-0); Randy Neisz advanced to third; Justin Erby scored. Deon Hammond advanced to second on a wild pitch. Taylor Erby grounded out to 3b (1-1 KB). 2 runs, 3 hits, 0 errors, 2 LOB.


I arrived well. Please don't worry about me.
There was a girl who left her home for achieving the dream to become a singer. Only several years later, she became the most promising female singer-songwriter in the Korean indie music scene, under the name of "Fromm". Before she even had a proper discography, her musical talent was already proven by being chosen as the "Hello-rookie" which was held under the sponsorship of the Korea Culture & Contents agency.
Since then, she has been invited to major Korean music festivals such as Jisan Valley Rock Festival (2012), Grand Mint Festival (2012) and Jisan World Rock Festival (2013).
"Arrival" is the first full-length album of this accomplished musician and the trigger for starting her career. "I arrived well. Please don't worry about me." As you listen to the first track "Arrival", the story starts after arriving somewhere. While it sounds like a brief trip, it is actually about a long journey of life. The lyrics are what she said to her family when she left her home and came up to Seoul to become a singer. Like this, the album consists of the things that she has faced in her life and what we also face in ours, such as fear of strange things, homesickness, reminiscence, love, loneliness and dreams. The allure of the album is that the themes mix well with analogue and vintage sounds, and acoustic instruments are in perfect harmony with the arrangements for wind and strings. Her candid and understated vocal tone also livens up the songs and arouses the listener's sympathy. Now, she has received an increase of support from Korean music fans with her new album, which fully shows her individuality, and she is waiting for the chance to introduce her songs to the wider world.


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5 Reasons for the Speedy Adoption of Blockchain Technology
By Regtech Africa November 24, 2020 81 views
Blockchain, the digital record-keeping technology behind Bitcoin and other cryptocurrency networks, has proven itself as a potential game changer in the world of finance. While still in its nascent stage, it is being compared to the status that Internet in the 1990s held.
Just like the internet was underrated in the 1990s, it is difficult to predict the impact of blockchain in the times to come. However, experts unanimously believe in its potential and are of one mind that the technology will very soon hit its tipping point for mass adoption.
Blockchain seems to be at the threshold of widespread acceptance and adoption. Recent surveys by blockchain marketing companies show that the attitude towards blockchain technology has changed measurably in an obvious manner and the technology is being seen in a positive light for its various applications. There has been remarkable progress in terms of adoption and implementation of the technology to provide solutions to real-world problems across a variety of businesses and sectors.
Owing to this trend, several organizations have increased their investments in the technology and are demonstrating their commitment to it.
Blockchain is finding applications across a multitude of industries and several novel businesses are cropping up every day. Some of the more prominent ones include blockchain backed supply chain management, blockchain marketing agencies, blockchain products that improve coordination between teams, blockchain content writers, blockchain-backed human resource services, and many more.
Five key factors of progress have been identified that can be credited for the wider adoption of blockchain. These reasons include:
Increased Throughput and Performance
Blockchain technology can only handle three to seven transactions per second, while the legacy transaction processing system is able to process tens of thousands of them every second. This led many observers to be unsure of the potential of blockchain as a viable option for large-scale applications. However, recent developments have resulted in promising way to close this performance gap and a new consensus mechanism is being developed.
This mechanism is enabling participants (some of who are unknown to each other) to trust the validity of the transactions. While the performance may be sluggish and a lot of computational resources may be spent in the mechanism involving blockchain, the better performance is the key that is popularizing the use of the blockchain technology.
Latest designs are aiming to reduce the time and energy intensive mining required to validate every transaction. Various blockchain-based applications are able to choose between performance, functionality, and security to suit what is most appropriate for the application. This consensus model is being especially appreciated in industries like auto-leasing, insurance, healthcare, supply chain management, trading, and more.
Improving Standards and Interoperability
A lack of standards has resulted in limited creative freedom to blockchain developers, blockchain content writers, as well as blockchain marketing agencies. The use of multiple coding languages, protocols, consensus mechanisms, and even privacy measures means that the platform is unable to communicate without the help of translators, thus limiting its functionality.
Standardization methods are being introduced to enable enterprises collaborate on the application development, validate proof of concept, and even share solutions for various blockchain related problems. These measures are giving positive results in terms of ease of integration with existing systems. There has been a significant increase in the number of industry participants which is helping make cross-blockchain transactions, interconnectivity, and standardization much easier. The industry is working towards achieving the goal of interoperability by adopting existing standards and making them work in the content of new blockchain applications.
Reducing the Complexity and Cost of Technology
One of the major obstacles to the widespread adoption of blockchain technology has been the cost and complexity involved in the building and deploying of blockchain solutions in various industries. This challenge has been addressed by a number of big technology vendors through the provision of cloud-based blockchain technology as a solution.
The cloud offerings have significantly improved the situation by lowering the barriers to developing and operating blockchain networks. In fact, cloud-based providers are even offering blockchain templates that are helping automate the setup of basic blockchain infrastructure. This step has reduced the time taken for application development significantly. These providers are further partnering with developers of blockchain-building tools to give access to easy development methods.
Additionally, latest software platforms are making the development and deployment of blockchain applications much simpler. Developers are also being able to create apps in their preferred language without worrying about the underlying technology. This clear trend in favour of easy-to-use blockchain tools and platforms is fostering wider and deeper penetration of blockchain technology in every industry.
The lack of regulatory bodies to solve issues as they arise was one of the major barriers that were inhibiting the widespread adoption of the blockchain technology. It was one of the factors discouraging investors from investing heavily into blockchain-backed products. The blockchain technology has introduced a series of new concepts like cryptographic signatures and smart contracts that are not covered under the existing regulations.
An official action was in order for this technology to make progress of any kind, and this year a number of bills were passed that recognized and defined in legal terms the various concepts inherent to the blockchain technology based products and services.
Removing major regulatory hurdles to blockchain adoption is still a work in progress, but the momentum is definitely building. Blockchain enthusiasts are positive about progress in this area, which is helping increase the adoption of blockchain technology.
Multiplying Consortia
Blockchain technology facilitates transactions across a large network and the value of this network increases with the increase in the number of users. The growth of blockchain consortia is a positive sign indicating wider adoption of the technology. The consortia comprises a group of companies that are working towards a common goal of defining use cases for the technology, developing infrastructure as well as futuristic applications, conducting research, and providing expert advice to collaborating members. The number of companies in the consortia has increased significantly in the last year itself – indicating improved adoption.
Growing participation has greatly affected the level of enthusiasm with which the technology is being seen and implemented.
The five factors listed above are greatly helping by lowering the cost of deployment of blockchain technology and expanding its practical applications. It is imperative for companies to keep an eye on the emerging mechanisms and techniques designed to increase transaction speed exponentially in order to stay abreast with the times. Blockchain developers and early adopters should intensify their efforts to improve the interoperability of the technology to ensure collective gain of the business community.
Though the technology is still nascent, firms are collaborating with lawmakers as well as policy makers to create a solid regulatory framework and fast track its adoption throughout all sectors.
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New figures suggest 1 in 6 people in England have a mental health condition
New figures from NHS Digital suggest that at any given time, 1 in 6 people in England suffer from a mental health condition.
The statistics indicate that the vast majority of people will either experience mental health problems or know somebody who has symptoms of a psychological condition. Mental health issues are often a lot harder to spot than physical problems due to the lack of visible symptoms, but research suggests that mental health conditions are increasingly prevalent in England. There is also a suggestion that the figures could be even more alarming, given that the statistics do not include more minor illnesses.
As the Prime Minister prepares to shed light on new measures to improve mental health diagnosis and treatment in England, there are several challenges facing the NHS and the Department of Health. Perhaps the most important consideration is the increasing prevalence of severe mental health illnesses. NHS Digital figures show that the proportion of people with 'severe symptoms' has increased from just under 7% in 1993 to over 9% in 2014. The rise has been particularly noticeable in women and although it is certain that people are more willing to see a doctor with signs of mental health problems than they were in years gone by, there is also a belief that modern life is contributing to rising rates. People are under more pressure, there's uncertainty related to safety, security and financial stability and many are working long hours in stressful roles.
Research indicates that mental health is an issue that affects everyone, but there is a worrying trend emerging among young people. It is possible that changes in the way society views mental health make it more viable for young people to speak up about psychological symptoms, but the world has also changed, and young people are growing up in a very different society. There are worries about the influence of the media and social media and it's common for young people to express concerns about expectations for the future and fear related to getting jobs, making money and growing up in a world where there are real threats, such as terrorism.
Health experts share their tips for improved health in 2019-6907
Concerns grow for the mental health of doctors, as suicide rate increases in England-2255
Scroll Free September campaign challenges social media users to log off for a month-3004
Gaming can be an addiction, according to new World Health Organization guidelines-0005
New figures confirm biggest fall in suicide rates in 20 years-9033
Tags: 1 in 6, Fear, mental health, Survey
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An overall rating is a common element in sports video games, including NBA Live and NBA 2K. It is intended to be a representation of a player or team's overall skill and value, and by extension, their relative ranking in the league.
In the early days of basketball gaming, overall ratings were a hidden attribute, as they served no real in-game function. As season and franchise modes were fleshed out and AI-controlled teams given the ability to reject trades, they gained significance and thus began to be displayed in the games. The maximum overall rating in most games is 99.
1 Calculation
3 Criticism & Controversy
Calculation[edit]
Overall ratings are calculated using a player's individual ratings, or in the case of teams, the ratings of all the players on the roster. The formula to calculate overall ratings has varied between games, which has led to inconsistencies in the way that player value is represented. For example, an overall rating of 85 might represent a second tier All-Star in one game, and one of the top five players in the league in another. As the years have progressed, efforts have been made to further differentiate players, and reserve overall ratings of 90 or higher to the best of the best.
A common problem in the calculation of overall ratings is the lack of appropriate weighting for certain individual attributes, particularly athletic ratings. This can result in certain players appearing to be overrated or underrated, with some of their individual ratings artificially increasing or decreasing the overall. As such, there is a certain lack of precision and accuracy in overall ratings, and it's generally not been possible to achieve perfect results in terms of ranking and rating players.
One of the main purposes of overall ratings is to reflect a player's overall skill level and rank in the league, at a glance. Gamers can immediately identify the best players on a team or in the league, simply by looking at their overall rating. It also provides a succinct summary of a player's value, relative to their peers.
In terms of the game's mechanics, overall ratings and their implied value are significant in franchise modes such as Dynasty, Association, MyLEAGUE, and MyGM. The AI will take a player's overall rating into account when evaluating the value and fairness of a trade offer, and will also generally only make offers that include players with similar or equal overall ratings. As franchise modes have become more sophisticated, other player attributes have become important factors, but overall ratings remain the starting point for evaluating player value in trades.
Criticism & Controversy[edit]
Although overall ratings are significant and do serve a purpose, their importance is sometimes overblown. As mentioned above, the method of calculating overall ratings is not always ideal, and players may end up appearing to be slightly underrated or overrated due to certain individual attributes being unsuitably weighted. As the individual ratings and other attributes are far more important in determining a player's level of skill and style of play, it's more important that they are accurate, rather than being fudged in order to make the overall look "better".
It has been suggested that overall ratings should be a hidden attribute once more, to eliminate this problem. However, the suggestion is generally unpopular and seen as unfeasible, since overall ratings are still important, and serve a useful function.
Retrieved from "https://www.nba-live.com/nbalivewiki/index.php?title=Overall_Rating&oldid=7231"
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Auction 344 – January 17-19, 2023
Click to View PDF Catalog
We are starting off the New Year right. Our sale #344 has a very good cross section of philately.
We are fortunate to have another strong selection of covers and postcards including better unlisted U.S. stampless, a large group of Akron and Macon, a strong group of Naval, Civil War, patriotic, space, sports, Zeppelin, a very large group of accumulations, nice postal stationery, U.S. and worldwide FDCs, (and to me the neatest of all) a very nice Ballon Monte and much more.
Our U.S. section features a single and block of #292 "Cattle in Storm." There is also J36b plate strip of 16, R66b, R99c, and more. Then a nice group of U.S. accumulations and collections.
In the worldwide section there are numerous China lots, a big section of Iceland and again many large lots as well. Plenty of hunting for treasures!
Viewing will be open by appointment only beginning Tuesday, December 20th. Please call or email to schedule an appointment.
1st Session (Lot 1-530) – Tuesday, January 17, 2023 – 10:00 AM ET
2nd Session (Lot 531-1164) – Wednesday, January 18, 2023 – 10:00 AM ET
3rd Session (Lots 1165-1719) – Thursday, January 19, 2023 – 10:00 AM ET
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