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Health Ministry fails to suspend violent nurses
Observer April 2, 2021
Kandjemuni Kamuiiri and Rose-Mary Haufiku
The Ministry of Health and Social Services (MoHSS) says its hands are tied when it comes to taking disciplinary action against the three unidentified nurses from the Oshakati Intermediate Hospital who were filmed physically and verbally assaulting a patient.
The ministry has not suspended the three but instead assigned them new duties at the hospital while the matter is being investigated. Health Executive Director, Ben Nangombe, said, the Public Service Act dictates the circumstances under which a staff member in the public service may be suspended. "Suspension should first be conducted or effected when you receive recommendations from the Public Service Commission.
That's why we are saying, we are going to act in terms of the provision of the Public Service Act. Suspension can be effected when you believe that the person may interfere with the witness or interfere with documents. I think in this particular case we do not believe that there is a possibility of this person interfering with witnesses or the people who are involved."
Based on the Public Service Act of 1995, Nangombe said that an investigation will commence to establish all the relevant facts for appropriate action to be taken.
"The Ministry has informed the Public Service Commission about the incident. It is thus the duty of the Public Service Act to make provisions for circumstances under which a staff member in the public service may be suspended."
Nangombe said the Ministry has also reported the matter to the Health Professions Councils of Namibia. "The Executive Director has reached out to the family of the patient to assure and inform them about the steps to be taken and to offer our sincere apologies for the inhumane treatment of their family member," he added.
Nangombe said the Ministry condemned, in the strongest terms, the "heartless" act against an elderly patient placed in the Ministry's hands, for care.
The incident is reported to have occurred on the night of 28 March. Based on the videos, after getting beaten and verbally abused by the health care workers, the patient said "I'm tired of getting beaten, I should just go die at home."
When contacted for comments, Namibian Nurses Union Secretary General, Junias Shilunga, said he is unable to comment without the full details on the incident, as he was not fully aware of it. "As a Union, we will be required to get a thorough report about the whole thing. For now I won't be at liberty to comment much on it," he said.
"It is not how we should treat a patient. Our people need to be treated with humility and dignity. The moment we get a full report we will comment with authority."
Registrar of the Nursing Council of Namibia, Cornelius Weyulu told Windhoek Observer that , " the conduct of nurses in the video clip falls below the expected professional standard and that the ultimate aim of the Council is to protect the public against unprofessional conduct of the nurses and midwives/accoucheurs."
"The Council has learned with a great displeasure the contents of the recorded video clip circulating on social media pages of the two nurses and a person in full personal protective gears attending to a patient at the Oshakati Intermediate Hospital and one of the nurses slapping that patient."
In terms of the Nursing Act and regulations promulgated thereunder, Weyulu stated that "the Council is empowered to take appropriate action against any registered enrolled nurse or midwife/ accoucheur who contravene the codes of conduct set by the law."
Human Rights Lawyer, Norman Tjombe, who reached out on social media, seeking for the details of the victim to handle the matter, said he had made contact with the victim's family.
"We don't know what the full facts are, once I get that, I will know what to do," he told the Windhoek Observer.
Ben NangombeHealth Executive DirectorJunias ShilungaMinistry of Health and Social Services (MOHSS)Namibian Nurses Union Secretary GeneralOshakati Intermediate Hospitalthree unidentified nurses
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redpajama_set_name: RedPajamaGithub


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My dear friend Vel...I am so sad and shocked by this news. Please accept my sincerest condolences! I am traveling for work this week, so I will not be able to be at the funeral. Please know I am sending you special prayers for comfort and peace now and always.
I'll miss your always smiling face and up lifting attitude . You will be missed.
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A drug designed to treat a common form of leukemia at first appeared to bring an alarming result: The number of cancer cells in the patient's blood spiked instead of decreasing. UC Irvine mathematicians brought powerful techniques to bear on the problem, helping usher in the emerging field of computational biology.
By building a mathematical model of the drug, Ibrutinib, and its effect on cancer cells associated with CLL-type leukemia, the scientists discovered that the drug really was doing its job – despite an initial increase in cancer cells migrating from tissues into the bloodstream. The drug was later approved for use in cancer treatment. A second leap of insight came when the researchers again used mathematical models to pin down the development of a patient's resistance to the same drug during treatment.
Simply by creating models that included the divisions, deaths and mutations of cancer cells, the scientists were able to predict how long it would be before the patient began to develop significant drug resistance. That, in turn, will allow doctors to adjust drug combinations and create "personalized" treatments tailored to each individual patient.
UCI mathematicians are at the forefront of the emerging fields of personalized medicine and computational biology. Their computer simulations range across the realms of biology and biomedicine, from stem cells and embryonic development to tissue regeneration and cancer. They're developing predictive models to unravel the mysteries of normal tissue development and how it can go awry, leading to birth defects, cancer and other diseases. The same tools could yield insight into both normal and abnormal functioning of the immune system, as well as improved treatment of cancer.


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El desarrollo económico de China influyó por completo en la expansión de la Dinastía Han en Asia. Por tanto, también ayudó a mejorar el tráfico con Mongolia, Asia Central, Corea, China del sur o el norte de la India, llegando con ello, la expansión militar y diplomática. Tanto fue su influencia y su riqueza que a finales del S.I antes de nuestra era ya no fue necesario continuar con la colonización en la China del norte y noroeste.

El origen del comercio y la expansión
Se conoce que ya en los siglos IV y III se desarrollaron intercambios comerciales, como los de los reinos de Zhao y de Qin hacia Mongolia o Asia Central, gracias a excavaciones en  y Corea del Norte, donde se encontraron numerosas monedas de mingdao, demostrando la existencia de tráfico entre el reino de Yan y los territorios del noreste. Sin embargo, el comercio aumentaría y se desarrollaría con los Han.

Son muchos los indicios que relacionan la expansión de los Han a finales del S.II, con el descubrimiento de las grandes vías comerciales que unían el mundo chino. El vínculo se establecía entre China del sur y Asia del sureste, con Asia Central y los límites de India e Irán.

Una de las causas de la expansión hacia la cuenta el Tarim y el Pamir fue un informe de Zhang Qian en el cual destacaba el interés de distintas poblaciones por las sedas chinas, incitando así al emperador Wudi a llevar expediciones al Yunnan y así controlar las rutas de bambús y tejidos procedentes del Sichuan. Y lo que causó las expediciones de los Han al Guizhou fueron las deducciones de la existencia de una ruta comercial entre Sichuan y Panyu.

Tanto el desarrollo económico como su expansión política iban a aumentar la importancia del tráfico y a estrechar aún más los lazos que unían el comercio con la guerra y la diplomacia. Todo esto creó una situación muy favorable para los mercaderes.

En las ciudades fronterizas se establecieron grandes mercados y las guarniciones chinas participaban en el comercio. Uno de los grandes mercados conocidos y que sirve de ejemplo es el de la actual Zhangjiakou, al noroeste de Pekín, donde comercializan los wuhuan y los xianbei. Los mercaderes se aprovechan de esas guarniciones chinas, llegando incluso a proclamarse representantes titulares de sus países si venían de países lejanos.

Las zonas de los oasis se vio repleta de mercaderes chinos tras la apertura de Asia Central por el ejército de los Hans en la época del emperador Wu. En cualquier caso, la política exterior de los Hans parece haber sido fundada en los intercambios de bienes preciosos. La intención de los Hans era, más que otros objetivos, aumentar sus relaciones diplomáticas. Por ello, al principio controlaban con frecuencia las rutas comerciales estableciendo guarniciones en los puntos por donde pasaban las caravanas de los mercaderes. Esta estrategia la llevaron a cabo en todas las regiones amenazadas, como en el oasis de Asia Central, y en regiones montañosas de la China del suroeste.

Los intercambios y el tráfico de la seda
Los Hans llevaron a cabo una política de lujos y generosidad al mismo tiempo, lo cual sorprende por su elevado coste y su personalidad sistemática. Pues, sin duda alguna, ningún país en el mundo llegó dar a sus vecinos tantos regalos, como sedas u otros productos chinos, al igual que ellos a las poblaciones de la estepa y el oasis o a las regiones montañosas de la China del suroeste durante los cuatro siglos de su época. Estos regalos fueron ya muy importantes a principios del S.II, aumentando rápidamente en la segunda mitad del S.I antes de nuestra era, y alcanzando la cifra máxima con los segundos Hans. Durante un año, se contó que a los xiongnu del sur, los regalos de seda tenían un valor de 100.900.000 piezas de qian. Y los reinos de los oasis unas 74.800.000 monedas. Sin embargo, en la segunda misión a finales del S.II de Zhang Qian a Dzungaria y Pamir, la seda había perdido su atractivo y su valor debido a la abundancia en estas zonas de ella.

Se ha estimado alrededor de 10.000 millones de piezas de moneda en las rentas anuales del imperio entre el S.I antes de nuestra era y el 150. Todo esto sin contar con las rentas privadas, que subían a 8.000 millones. Aun así, buena parte de esos millones, se invertían para los regalos de las poblaciones vecinas. Esto supuso para China el aumento de la producción artesanal y al mismo tiempo, el debilitamiento de la economía general del imperio. Además, efectos en el comercio entre Asia Oriental, India del norte, Irán y la cuenca mediterránea.

La ruta de la seda unía el valle del río Amarillo con el Mediterráneo (que pasaba por ciudades del Gansu, los oasis de Xinjiang, el Pamir, la Transoxiana, Irán Irak y Siria). Pero, la ruta que bordea por el sur del desierto de Takla-Makan, fue uno de los grandes centros de tránsito de la seda, puesto que aquí se han encontrado restos de tejidos de seda que presentan analogías con las que se han descubierto en las tumbas de Palmira.

La seda procedente o fabricada en Sichuan era conocida como producto del reino de Qin en las llanuras del Ganges y del Indo desde los S.IV-III antes de nuestra era. Pero indicios arqueológicos muestran que las relaciones entre China y la India se desarrollaron con los la expansión de los Hans en Asia Central. Tampoco debemos olvidar que el comercio de la seda se extendió por toda Asia, aunque la mayoría del tejido tomara rumbo hacia Oriente o la cuenca del mediterráneo.

Ahora bien, si querías evitar que los nabateos, quienes controlaban el comercio entre Transoxiana, Irán y el Mediterráneo, te cobrasen una tasa de 25% de las mercancías; entonces, las sedas debían importarse directamente del valle del Indo.

La economía en la sociedad (desarrollos tecnológicos)

Progresos de la metalurgia del hierro y otras industrias.
Bajo los Hans continuaron los progresos con la metalurgia del hierro, pero no sería hasta el S.VI cuando se vería descrito el procedimiento moderno Siemens-Martín. Ahora bien, los chinos supieron desde el S.II producir acero calentando y trabajando con hierros y diferentes contenidos de carbono. Sustituyendo entonces las armas de acero por otras de bronce que parecen ser las únicas que se conoció en la época de los Reinos Combatientes; una época donde la producción del hierro era exclusivamente para instrumentos agrícolas.

La artesanía del hierro era la más activa e importante durante la Dinastía Han, y gracias a los monopolios del estado de hierro y sal, se crearon cuarenta y ocho fundiciones donde trabajaban obreros (reclutas o condenados) conocidos por el nombre de tongzi.

Los grandes talleres del estado se encargaban del funcionamiento de cargas pesadas, y cuya producción iba destinada básicamente a los regalos de los vecinos. Se encontraban en la capital, que era Chang'an, y trabajaban miles de obreros. También habían empresas privadas creadas por familias ricas de mercaderes.

En el caso de la producción de lacas, sucedía algo similar. Eran fabricadas sobre todo en Sichuan y Henan. Muchos descubrimientos arqueológicos mostraban en muchas piezas el nombre de quienes dirigieron la fabricación, otras no, por tanto se deducen que podrían ser de talleres privados.

La artesanía del cobre fue también importante, siendo las monedas y los espejos de bronce los productos principales. Los espejos fueron importantes en el primer siglo de nuestra era para la exportación, encontrándose restos en Siberia, Vietnam y Rusia meridional.

Mejora de la producción agrícola.
Las técnicas agrícolas mejoraron, pues los instrumentos de hierro eran de mejor calidad, y el uso del arado con bueyes se generaliza. Con el emperador Wudi, se crearon nuevas tierras en el norte de China. Además, expertos agrónomos difundieron nuevos métodos de cultivo, enseñando a pueblos nómadas de más allá de las Murallas a cultivar cereales. Continuaron los cultivos de cebada, trigo y mijo, y se sumaron la soja y el arroz. Asimismo, la alfalfa (hierba musu), permitió el desarrollo de la cría de caballos.

Apareció con Wang Mang el molino de agua. Apareció también el arnés del tirante con los Reinos Combatientes cuando la carreta de doble vara fue sustituida por el carro de timón. En la época de los Hans se creó un vehículo importante, la carretilla, un instrumento muy útil para senderos estrechos que permitía transportar una carga de 150 kg con poco esfuerzo. Y, por último, la China de los Hans contó con gran abundancia de animales de tiro (bueyes, caballos y burros), y de transportes.

Véase también

 Dinastía Han
 Dinastía Qin
 Economía de la Dinastía Han
 Anexo: emperadores de China

Bibliografía
- Jacques Gernet (1972). El mundo chino. Crítica. Barcelona: Ed. M.ª Dolors Folch Fornesa. (2018). ISBN: 9788417067915.

redpajama_set_name: RedPajamaWikipedia


Olympus registered a new Camera at Russian Wireless registration agency. The model code name of the camera is IM010. Based on rumors we are getting Olympus do planned a Major announcement on Photokina 2019 or may be just before that.
The Only camera left for an update in Olympus line-up is the Olympus E-M5 Mark II. We may see a affordable E-M1 Mark II camera under Olympus E-M5 Mark III body.
We will update you soon as we get nay new information. Do share your thoughts on the comment box below.
The list of upcoming Olympus camera in 2018-2019 and even one in 2020. Yes, based on scheduled announcement date of Olympus we have made the table below, which clearly shows the possible arrival time of Olympus E-M5 Mark III, Olympus E-M1 mark III and Olympus E-M10 Mark IV Mirrorless cameras.
The table we have made to make you understand the announcement schedule of Olympus EM series Mirrorless camera. Take a look at the different announcement dates every series, based on the announcement timeline we are expecting one announcement in Jan / Feb of 2019 and after that we will have a Major announcement in Sep of 2019.
As you have seen Olympus skipped the scheduled announcement date of Olympus E-M5 Mark II camera which was Jan / Feb 2018. Now we are expecting the arrival of Olympus E-M5 Mark III camera either on Sep 2018, during Photokina event. Since, Photokina is the best place for announcement of Camera, Lenses and camcorders. And even if the Sep 2018 date is missed than for sure E-M5 Mark III will going to arrive on Jan/ Feb of 2019.
We are the first website to publish the rumored specification of the Olympus E-M5 mark III camera. And if we believe it then we will going to see big improvements compared to the existing E-M5 mark II camera. The rumored specification of the camera look similar to E-M1 Mark II. And in the same post that was published on April 30 2018 we have also told that the Olympus E-M5 Mark III camera will going to arrive either at the end of 2018 or maybe in the beginning 2019.
Olympus E-M1 Mark III schedule announcement date is September 2019. However, even due to delayed in the announcement of E-M5 Mark III camera, we are expecting the Olympus E-M1 Mark III camera will arrive on time without any delay.
But, at the same time their is strong possibility that E-M1 Mark III camera will arrive on schedule time, since we have 2020 Olympics start from July 2019 and prior to that All major DSLR as well as Mirrorless makers will going to announce their flagship DSLR and Mirrorless camera. We are expecting the announcement of Panasonic GH6 [first consumer level 6K camera], Canon 1DX Mark III and Nikon D6 at the end of 2019 or at the beginning months of 2020.
Scheduled time of Olympus next entry level Mirrorless camera Olympus E-M10 Mark IV, which was expected to be Aug of 2019, but it will be shifted to Aug of 2020. Since the E-M5 series update is delayed for 1 year. And E-M1 Mark II announcement is expected on Sep of 2019.
The Olympus E-M5 Mark II was announced on May 12, 2015. So its almost more than two years completed and we do expect Olympus E-M5 Mark III from Olympus this year or may be at the beginning of 2018.
Update – The registered model code was of the Olympus E-PL9 camera. The Camera Olympus E-M5 mark II no details available yet and we will update ypu soon as we get any new information.


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Great-grandmother surprised with special promposal. She said yes.
Wearing a black dress and a white rose corsage on her wrist, Marie Antone followed her prom date onto the crowded, dimly lit dance floor.
"This one is going out to Marie," the DJ announced. As the first notes of one of her favorite songs played, Antone's date gently took her hands. Together they swayed from side to side.
This was Antone's first prom, something she never imagined she'd experience. She turned 74 last November, and has 20 great-grandchildren.
Her date is Chief Sealth graduate Juan "Neeto" Old Chief Betancourt. The 18-year-old wanted to honor Antone, his great-grandmother, by bringing her to his senior prom at the Seattle Art Museum in June.
"In our ways, like, the women are like the strong ones," said Betancourt, who is Squamish, Yakama and Blackfeet. "They're like the backbone pretty much." Antone is "loving, full of knowledge, quiet and powerful," he added.
Betancourt surprised Antone with a "promposal" at her West Seattle home with a sign that read, "Grandma gives the best hugs and kisses." The poster board was decorated with her favorite candy, Hershey's Kisses.
"It was a wonderful surprise," said Antone.
Betancourt said his great-grandmother, who helped raise him, puts others ahead of herself. She taught him to forgive, be humble and to have a positive impact in the world, he said. He wanted the evening to celebrate her contributions to their family.
Antone wasn't able to attend prom in her youth. She lived in dozens of foster homes while growing up in Washington and Montana, after being abandoned by her mother. The Zack family on the Yakama Nation adopted her in her teenage years, and that's where she would later meet her husband. Together they had four children.
The hardships that Antone endured have made Betancourt recognize "there's always someone out there that can have it way worse than you," he said. "Family always comes first."
Uncle Bert Nolan drove Antone, Betancourt and his girlfriend, Kalei Bressler, from Salty's restaurant in West Seattle to the dance in his 1964 Impala. The night culminated with Betancourt requesting Shania Twain's, "Man! I Feel Like a Woman!"
Antone, who loves country music, danced with her great-grandson underneath a sculpture of a 140-year-old western hemlock tree.
Betancourt will participate this summer in the Power Paddle to Puyallup 2018 Tribal Canoe Journey, and will also attend powwows across the country where he will chicken dance.
He wants to finish college, "start working and help my family," Betancourt said.
Like his great-grandmother, he wants to "be an inspiration."


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Home Scleroderma News *ScleroForums* Support World
Scleroderma Research Treatments Mainstream
Biologic Agents
Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases
Author: Janey Willis. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of Biologic Agents
Alemtuzumab (Campath)
Etanercept (Enbrel, Benepali) Infliximab (Remicade)
Rituximab (Rituxan)
TNF Inhibitors
Biologics or biologic agents are biologic response modifying agents that block specific pathways and signals of inflammation. Some of the biologics used to treat rheumatic diseases include etanercept (Enbrel), infliximab (Remicade), adalimumab (Humira), abatacept (Orencia), and rituximab (Rituxan). (Also see What is Scleroderma?, Medical Overview, and Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases)
Different biologics block different arm of the immune system. For example, etanercept, infliximab, and adalimumab block tumor necrosis factor (TNF), abatacept blocks an interaction between T cells and macrophages, and rituximab effectively eliminates B cells for several months.
Evaluation of response criteria in rheumatoid arthritis treated with biological disease–modifying antirheumatic drugs. EULAR response criteria overestimate the response under Interleukin-6 inhibitors treatment because the acute–phase reactants improvement largely contributes to the Disease Activity Score 28 improvement. PubMed, Arthritis Care Res (Hoboken), 05/06/2019.
The Effect of Pregnancy on Disease Activity in Patients with Psoriatic Arthritis. Continuation of biologics therapy was associated with a low level of disease activity and a low probability of flare during pregnancy. PubMed, J Rheumatol, 2018 Dec;45(12):1651-1655. (Also see Psoriasis and Psoriatic Arthritis)
Association between autophagy and inflammation in patients with rheumatoid arthritis (RA) receiving biologic therapy. Elevated autophagy with significant correlation to inflammation suggests the involvement of autophagy in RA pathogenesis. PubMed, Arthritis Res Ther, 2018 Dec 5;20(1):268. (Also see Treatments for Rheumatoid Arthritis)
Drug Utilization Patterns and Adherence in Patients on Systemic Medications for the Treatment of Psoriasis: A Retrospective Comparative Cohort Study. We report greater adherence in new users of biologics when compared to methotrexate. PubMed, J Am Acad Dermatol, 07/04/2018. (Also see Psoriasis and Psoriatic Arthritis)
Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis. Strategic treatment in which different bDMARDs were selected according to phenotypic differences in helper T cells showed significantly higher efficacy. PubMed, Rheumatology (Oxford), 04/02/2018. (Also see Psoriasis and Psoriatic Arthritis)
Residual disease activity (RDA) in rheumatoid arthritis (RA) patients treated with subcutaneous biologic drugs that achieved remission or low disease activity (LDA). RDA in RA was present even in patients with remission or LDA, especially for the patient's reported outcome and impaired function was also present in a significantly rate of patients. PubMed, Clin Rheumatol, 02/21/2018. (Also see Treatments for Rheumatoid Arthritis)
Biologics or tofacitinib for people with rheumatoid arthritis (RA) unsuccessfully treated with biologics: a systematic review and network meta-analysis. Biologic or tofacitinib use was associated with clinically meaningful and statistically significant benefits compared to placebo or an active comparator among people with RA previously unsuccessfully treated with biologics. PubMed, Cochrane Database Syst Rev, 2017 Mar 10;3:CD012591. (Also see Treatments for Rheumatoid Arthritis)
'Generic' Biologic Drugs Appear Comparable to Brand–Name Counterparts. New analysis suggests common and costly medications made from living cells can be equivalent even when manufactured by different company. Johns Hopkins News Release, 08/01/2016.
Use of Biologics in Sjögren's Syndrome. In this review, we summarize the current evidence regarding B–cell targeted and anti–TNF therapies and provide an overview of promising drugs in the pipeline. Rheumatic Disease Clinics, 06/21/2016. (Also see Treatments for Symptoms of Sjögren's Syndrome)
B-cell survival factors in autoimmune rheumatic disorders. The information on the use of biologic agents blocking B-cell activating factor and A proliferation inducing ligand for patients with lupus, rheumatoid arthritis, Sjögren's syndrome and myositis has been updated. Therapeutic Advances in Musculoskeletal Disease, 07/17/2015.
FDA Alert: Alemtuzumab (marketed as Campath) Information. Three patients in a clinical study of the drug Campath for the treatment of Multiple Sclerosis (MS) developed severe idiopathic thrombocytopenic purpura (ITP). One of the patients died. U.S. Food and Drug Administration. 11/05.
Alemtuzumab (Campath): Side Effects. Safety data, except where indicated, are based on 149 patients with B-CLL enrolled in studies of Campath as a single agent administered at a maintenance dose of 30 mg intravenously three times weekly for 4 to 12 weeks. RxList.
Etanercept (Enbrel®, Benepali) by Biogen
Enbrel® is a rheumatoid arthritis medication that may also be used to treat scleroderma joint pain and stiffness.
Benepali® (Etanercept) is the first etanercept biosimilar referencing Enbrel ® approved in the European Union (EU). It is indicated for adults in the EU to treat moderate to severe active rheumatoid arthritis, psoriasis and psoriatic arthritis, and spondyloarthritis. Biogen.
Enbrel® (etanercept) treats moderate to severe plaque psoriasis from inside the body, rather than at the surface where you see skin symptoms. It works on your immune system to help stop skin cells from growing too quickly. Amgen.
Low Doses of Etanercept (ETN) Can Be Effective to Maintain Remission in Psoriatic Arthritis (PsA) Patients. The main reasons that hinder the dosing interval increase in ETN in PsA patients are peripheral polyarthritis pattern and exacerbation of cutaneous manifestations. PubMed, J Clin Rheumatol, 2018 Apr;24(3):127-131. (Also see Psoriasis and Psoriatic Arthritis)
The effect of etanercept on traditional metabolic risk factors for cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA). Patients with RA are at an increased risk of CVD and treatment with etanercept did not adversely affect levels of metabolic risk factors for CVD in patients with RA. PubMed, Clin Rheumatol, 10/05/2016. (Also see Treatments for Rheumatoid Arthritis)
Infliximab (Remicade). Patients treated with REMICADE are at increased risk for infections, including progression to serious infections leading to hospitalization or death. RxList.
An Open-Label Pilot Study Of Infliximab Therapy In Diffuse Cutaneous Systemic Sclerosis (dcSSc). In dcSSc infliximab did not show clear benefit at 26 weeks but was associated with clinical stabilisation and fall in two laboratory markers of collagen synthesis. The frequency of suspected infusion reactions may warrant additional immunosuppression in any future studies in SSc. C. P. Denton. (Also see Scleroderma Treatments)
Case Report: Successful treatment of infliximab in a patient with scleroderma. Signs and symptoms were continued improving during the course of treatment and skin biopsy showed significant reduction in fibroplasia finally. PubMed, Medicine (Baltimore).
Rituximab® (Rituxan) by Biogen and Genentech
People with serious infections should not receive Rituxan. It is not known if it is safe or effective in children.
RITUXAN® (Rituximab) is approved for treatment of rheumatoid arthritis, granulomatosis with polyangiitis (GPA) (formerly Wegener's Granulomatosis), microscopic polyangiitis (MPA), non-Hodgkin's lymphoma (NHL), and chronic lymphocytic leukemia (CLL). Biogen and Genentech.
Rituxan® (Targeted B-cell Therapy). Indications and Uses. FDA Warning. Rituxan.com.
Effects of treatment with rituximab on microcirculation in patients with long–term systemic sclerosis. Rituximab improves microcirculation in long–term SSc and stabilization and reduced progression of microcirculation abnormalities were achieved. PubMed, BMC Res Notes, 2018 Dec 10;11(1):874. (Also see Clinical Trials)
Rituximab for refractory rapidly progressive interstitial lung disease (RP–ILD) related to anti-MDA5 antibody–positive amyopathic dermatomyositis. Our results suggest that RTX may be a useful therapy for anti-MDA5 Ab-positive ADM associated with RP–ILD, although infection is the major risk. PubMed, Clin Rheumatol, 04/30/2018. (Also see Treatments for Dermatomyositis)
Two years follow–up of an open–label pilot study of treatment with rituximab in patients with early diffuse cutaneous systemic sclerosis (dcSSc). Rituximab appears to be safe and tolerable and it may have beneficial effects on skin involvement, on overall disease activity and on stabilization of internal organ status in early dcSSc. PubMed, Acta Clin Belg, 2017 Sep 11:1-7.
A multi–center, open–label, comparative study of B–cell depletion therapy with Rituximab (RTX) for systemic sclerosis–associated interstitial lung disease. Our data indicate that RTX has a beneficial effect on lung function and skin fibrosis in patients with SSc and randomized controlled studies are highly needed. Seminars in Arthritis and Rheumatism, 11/05/2016.
Disease Activity, Glucocorticoid (GC) Exposure, and Rituximab Determine Body Composition Changes during Induction Treatment of ANCA–Associated Vasculitis (AAV). Findings suggest that changes in BMI are independently associated with improvements in disease activity as well as GC exposure in AAV and rituximab may also have effects on BMI independent of its impact on disease activity. PubMed, Arthritis Care Res (Hoboken), 10/01/2016. (Also see Vasculitis)
(Case Report) Rituximab (RTX) for eosinophilic granulomatosis with polyangiitis with severe vasculitic neuropathy: Case report and review of current clinical evidence. RTX seems to be effective in cases of severe EGPA refractory to standard of care immunosuppressive treatment, although support comes from case reports and non-controlled studies. PubMed, Semin Arthritis Rheum.
Tumor Necrosis Factor (TNF) inhibitors include etanercept (Enbrel), infliximab (Remicade), and adalimumab (Humira)
Improved patient–reported outcomes (PROs) in patients with psoriatic arthritis (PsA) treated with abatacept: results from a phase 3 trial. Abatacept treatment improved PROs in patients with PsA versus placebo, with better results in elevated baseline C-reactive protein and tumour necrosis factor inhibitor– naïve subpopulations. BMC Journals, Arthritis Research & Therapy, 12/06/2018. (Also see Psoriasis and Psoriatic Arthritis)
Risk of active tuberculosis in patients with inflammatory arthritis receiving TNF inhibitors (TNFi): a look beyond the baseline tuberculosis screening protocol. 'Early TB' was exceeded by TB occurring after 1 year of TNFi treatment, thereby, suggesting that further TB prevention measures were required. PubMed, Clin Rheumatol, 2018 Sep;37(9):2391-2397. (Also see Extrapulmonary Tuberculosis)
Use of biological drugs in patients with psoriasis (PsO) and psoriatic arthritis (PsA) in Italy: Results from the PSONG survey. Adalimumab could be the best therapeutic option over other anti–TNF agents for the treatment of PsO and PsA patients. PubMed, Dermatol Ther, 12/07/2017. (Also see Psoriasis and Psoriatic Arthritis)
Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of Granulocyte–macrophage colony–stimulating factor (GM-CSF) and GM-CSF+ T Lymphocytes. The use of biomarker signatures of distinct pro-inflammatory pathways could lead to evidence-based prescription of the most appropriate biological therapies for different RA patients. PubMed, Clin Rev Allergy Immunol, 05/09/2017. (Also see Treatments for Rheumatoid Arthritis)
Biosimilars: implications for rheumatoid arthritis therapy. Five TNF inhibitor biosimilars have now been approved, and many other biosimilars to treat rheumatoid arthritis and other inflammatory diseases are in development. PubMed, Curr Opin Rheumatol, 03/16/2017. (Also see Treatments for Rheumatoid Arthritis)
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redpajama_set_name: RedPajamaCommonCrawl


text:
Q: What are the rules for structure alignment of nested structures? I'm trying to understand the rules for alignment of nested structures, specifically on Win32/MSVC. I have this structure:
struct outer {
    int a;
    struct {
        int aa;
        int bb;
    } inner;
    int d;
};

The inner structure has a size of 8 bytes; its two int fields pack nicely. Within the outer struct, the inner structure is located after a, which is 4 bytes. The inner structure has a size of 8. When I compile this code, it ends up having offset 4, which implies that the inner structure has an alignment requirement of 4.
I thought the size of inner (8) would be used as its alignment "granularity", but I'm clearly wrong. What is the rule that I should be applying to calculate these offsets?

redpajama_set_name: RedPajamaStackExchange


text:
package com.dz.store.es;

import com.google.common.io.Files;
import org.elasticsearch.client.Client;
import org.elasticsearch.common.settings.ImmutableSettings;
import org.elasticsearch.node.Node;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import java.io.File;

import static org.elasticsearch.node.NodeBuilder.nodeBuilder;

/**
 * @author mamad
 * @since 13/11/14.
 */
public final class EsClientBuilder {
    public static final Logger LOGGER = LoggerFactory.getLogger(EsClientBuilder.class);

    public static Node localNode(String cluster) {
        return localNode(cluster, Files.createTempDir());
    }

    public static Node localNode(String cluster, File dataFolder) {
        ImmutableSettings.Builder settings = ImmutableSettings.settingsBuilder()
                .put("http.enabled", "false")
                .put("path.data", dataFolder.getPath());
        return nodeBuilder().clusterName(cluster).local(true).settings(settings).node();
    }

    public static Client localClient(String cluster) {
        return localNode(cluster).client();
    }

    public static Client client(String cluster) {
        LOGGER.debug("Building ES client for cluster:{}", cluster);
        return nodeBuilder().clusterName(cluster).client(true).node().client();
    }

}


text:
FEMA Administrator Gaynor Has Experience But Faces Issues Pete Gaynor has extensive experience at the local and state level dealing with natural disasters, but he faces something different now.
FEMA Chief Gaynor Faces A New Challenge: Coronavirus Response
April 15, 20205:00 AM ET
FEMA Administrator Pete Gaynor speaks at a White House coronavirus task force briefing in March. Patrick Semansky/AP hide caption
Patrick Semansky/AP
FEMA Administrator Pete Gaynor speaks at a White House coronavirus task force briefing in March.
Leading the Federal Emergency Management Agency during the coronavirus pandemic may be one of the most thankless jobs in government right now. Governors are clamoring for more supplies, like ventilators and face masks. The president engages in public feuds with those governors. And other administration officials work back channels to acquire their own stockpiles of supplies.
And in the middle of all this is Pete Gaynor, a former Marine and former head of the Rhode Island Emergency Management Agency who now directs FEMA.
Jared Kushner's Role In Coronavirus Response Draws Scrutiny, Criticism
Known For Disaster Aid, FEMA Prepares For New Challenge With Coronavirus Relief
Gaynor has generally kept a low public profile, and FEMA would not make him available to be interviewed for this story.
Those who have worked with Gaynor speak highly of him.
"I think he's exceptional," former Providence, R.I., Mayor Angel Taveras tells NPR. The Democrat says Gaynor was the city's emergency management director when Taveras was elected, "and I was smart enough to keep him."
Daniel Kaniewski served as Gaynor's deputy at FEMA. He says the agency is "lucky to have a leader like Pete leading the agency during these trying times." Kaniewski says Gaynor, as a former state and local emergency management director, "understands the challenges facing those communities that are impacted by coronavirus right now."
Gaynor has certainly faced challenges as administrator.
FEMA was assigned the lead role in directing the federal coronavirus response on March 19, well after the pandemic had begun spreading in the United States, and the agency has been playing catch-up ever since as it tries to obtain supplies and distribute them to states, some of which have been sharply critical of its efforts.
New York Gov. Andrew Cuomo, a Democrat, accused the agency of fostering an eBay-type atmosphere, with governors forced to bid against each other and the federal government for crucial supplies such as ventilators.
"How inefficient!" Cuomo charged at a recent briefing. "And then FEMA gets involved and FEMA starts bidding. And now FEMA is bidding on top of the 50 [states]. So FEMA is driving up the price. What sense does this make?"
A worker wearing a protective mask uses a forklift to move boxes of medical equipment as New York Gov. Andrew Cuomo tours construction of a temporary FEMA hospital at the Jacob K. Javits Convention Center in New York City. Angus Mordant/Bloomberg via Getty Images hide caption
Angus Mordant/Bloomberg via Getty Images
A worker wearing a protective mask uses a forklift to move boxes of medical equipment as New York Gov. Andrew Cuomo tours construction of a temporary FEMA hospital at the Jacob K. Javits Convention Center in New York City.
Democrats have previously accused the Trump administration of transferring funds from FEMA to other parts of the Department of Homeland Security, including Immigration and Customs Enforcement, while the Government Accountability Office found FEMA to be understaffed.
The approximately $2 trillion emergency spending bill Congress approved in March, however, did include some $45 billion for FEMA to provide assistance to states in its disaster relief fund.
Gaynor was uncomfortably in the news when he went on CNN and said that FEMA would use the Defense Production Act to secure tens of thousands of test kits, only to be clarified later, when the agency said "at the last minute" they were able to procure the test kits from the private market without using the act.
Gaynor has also been forced to work with a White House that through the efforts of President Trump's son-in-law, Jared Kushner, has also had a hand in overseeing the distribution of supplies.
Kaniewski says that's not likely to bother Gaynor much.
"He's able to work alongside many of these senior officials, and that speaks well to his leadership style," Kaniewski says. "He's not looking for credit. He's looking to accomplish the mission."
Former Providence Mayor Taveras agrees, saying if the Trump administration "let[s] him do his job, I have no doubt that Americans will not only be confident, they will be grateful when all of this is over" for Gaynor's work.
But that's a big if. At a coronavirus task force news briefing in March, Gaynor was asked when states would be receiving the masks they'd asked for. In the middle of his answer, Trump interrupted and said he too wanted to know when the masks would be coming in. When Gaynor answered that "we're trying to match supplies with demand," Trump jumped in to say of Gaynor, "He's worse than I am." There was nervous laughter among the officials behind the podium.
Gaynor, the third person to hold the top FEMA post in the Trump administration, has rarely been seen at a task force briefing since.


Target capture methods allow for enrichment of selected regions of interest from DNA samples prior to next generation sequencing (NGS). By selecting target regions, or expression subsets, investigators can maximize both the number of samples that they can analyze and the number of times individual sequences in a sample are replicated (coverage) for every NGS run. This results in the highest statistical power per dollar spent. This webinar will discuss target capture methods and how IDT xGen™ target capture probes can be used to improve your sequencing data.


Loving to read can open a new world of possibilities for children. Help your little ones develop a love of reading and books with these stories and activities!
People have been telling stories since the beginning of time, in many different places and in many different ways. Share the power of these stories with new listeners!
Choose books and materials that make you excited about storytime. The children will pick up on your enthusiasm and follow your lead.
Plan a variety of activities during storytime. Know that every storytime group will have different needs. If you overplan your storytime, you will be prepared if a group needs to be more active.
Define your storytime space. Use a rug or chairs and cushions to show the area where you'll be reading. Before beginning storytime, set expectations for your listeners so they'll know how to behave during storytime.
Practice reading the book aloud before taking it into storytime. Make note of any tricky passages or difficult words to read. Use sticky notes attached to the back of the book to remind yourself of questions you want to ask the group or facts/details you want to point out.
Use an opening routine to help children realize that storytime is starting. This may be a song that you sing together, a rhyme like "Crisscross Applesauce," or it can even be putting a magic reading hat on your head.
Introduce the book by reading the title. Depending on the age of the group, include the author and illustrator as well. Ask the children what they think the story will be about based on the front cover. Follow up with these predictions at the end.
Take natural pauses as you read the book. Ask questions, call attention to smaller details in the illustrations, define new vocabulary words, and make sure that the group is following the story line.
After finishing the book, spend a few minutes talking with your group. Ask them questions to see if they've made any connections with previous knowledge, or answer new questions that might have come up during the book. Let your group react and process the book together.
Get up and move once you finish a book. Your group will likely be ready for an activity after sitting for a book. This is especially important if you're reading to younger children who have a harder time sitting still.
Once your storytime is over, take some time within the next day to evaluate how it went. If this is a consistent group of children that you see on a regular basis, jot down notes about what elements worked well or what you would change for next time.


text:
CHP: Officer involved shooting investigation prompts road closure in Prunedale
Updated: 9:15 PM PST Nov 24, 2019
Christopher Salas
Officer involved shooting investigation on Strawberry Road
The California Highway Patrol said the Monterey County District Attorney's Office is investigating an officer-involved shooting that took place Sunday.The CHP said they could not release any information into the shooting including when and where the it took place.The CHP said as of 8:50 p.m. there is a hard closure of Strawberry Road between San Miguel Canyon and Hidden Valley Road. This is a developing story we will update it as soon as we receive more information.
PRUNEDALE, Calif. —
The California Highway Patrol said the Monterey County District Attorney's Office is investigating an officer-involved shooting that took place Sunday.
The CHP said they could not release any information into the shooting including when and where the it took place.
The CHP said as of 8:50 p.m. there is a hard closure of Strawberry Road between San Miguel Canyon and Hidden Valley Road.
This is a developing story we will update it as soon as we receive more information.


Doors and windows can make up a huge part of any home renovation bill. You want to keep them in tip top shape for the life of the home. These parts can seriously compromise how well your doors and windows work if they are worn and broken. There are parts that wear out and some of them are parts that you can replace yourself.
Your new front door, or entrance system as they like to call them nowadays, might last a long time. But the weatherstrip or doorsweep on the bottom of it probably wont. They wear out and you need to change them. Here's what you need to know.
Ever had to open out your casement window and have the crank handle start turning and turning without the window going anywhere. Usually thats a sign of a broken Truth operator. Its called a Truth operator because thats the name of the huge company that makes so many of them.
If you have ever had to keep leaves out of your window wells you might like the solution that I am using here. Best of all its something that you can do yourself with a variety of perforated metal and meshes.


Bad Speler may be a side project of The Show Is the Rainbow, and the one-man act certainly has a similar level of live energy, but the sound is significantly different. There's a quality that hints at the early work of Girl Talk (not surprising considering that both are signed to Illegal Art and have a liberal use of sampling), but whereas Girl Talk has sort of gotten a little stale, Bad Speler still seems fresh. Check out photos from his live show below and download the latest mixes from Bad Speler at Illegal Art's website.


text:
Lucinda Youtan Re-joins Pure's Legal Practice
Home Page Original Content Press Room
Mark Powney , 16th May 2019
International search and recruitment firm Pure has welcomed back Lucinda Youtan to join its UK in-house legal practice. She will focus on senior legal appointments across commerce & industry.
Lucinda, who is a UK qualified lawyer, has over 8 years' legal recruitment experience. She began her recruitment career at Pure and during her 3-year tenure rose from Consultant to Director. During the course of her career Lucinda has successfully completed senior mandates for FTSE, fast-track and PE-backed businesses; she has also built and managed highly successful recruitment teams.
Lucinda says,
"I am thrilled to be re-joining Pure, especially at a time when the business is growing both in the UK and overseas. The platform and structure will enable me to build upon Pure's offering in the legal space, and I am excited to have the opportunity to work with its well-established teams."
Liam Richardson, who leads Pure's UK legal practice, comments
"Lucinda is an excellent recruiter with an impressive track record. I am looking forward to working with her to continue to build Pure's reputation as a leader in legal recruitment."
Pure London is complemented by offices in Hong Kong, Singapore, New York and Berlin, all operating across commerce & industry, financial services and professional services; a platform that means that Pure offers a truly global service.
MP Visits Local Firm to Discuss Developing Talent in the North
Hays Urges Recruitment to Better Support Mental Health in the Workplace
With over 15 years experience within the Recruitment industry, Mark considers digital publishing, digital engagement, recruitment marketing and advertising (all media), digital video production, creative design and more recently social media development as his core knowledge and where a lot of his experience lays.
Having been at the forefront of the digital publishing sector for well over a decade, Mark has founded numerous job boards and publishing businesses.
He has very strong business ethics, built on transparency and trust and equally as important, he enjoys close working relationships with all clients. A self-confessed digital geek Mark lives and breathes online media ensuring Recruitment Buzz stays ahead of the curve.


text:
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Uddevalla Church
Uddevalla, Sweden
The Neoclassical Uddevalla Church was built in 1810-1814. The architect was Gustaf af Sillén. It replaced a 17th century stone church on the same site that was largely destroyed by the great fire in the city a few years earlier. The altarpiece is a painting by Frederic Westin.
Marianne Mehling et al. Knaurs Kulturführer in Farbe. Schweden. München 1987.
Religious sites in Sweden
Union with Norway and Modernization (Sweden)
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Kyrkogatan 5, Uddevalla, Sweden
See all sites in Uddevalla
Founded: 1810-1814
Category: Religious sites in Sweden
Historical period: Union with Norway and Modernization (Sweden)
4.3/5 (based on Google user reviews)
Interesting Sites Nearby
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Håkan Gniste (11 months ago)
Uddevalla's cathedral in the middle of town among the people.
Janeke Irgens (2 years ago)
They had an evening around suicide prevention in collaboration with other actors. Very good that the church is getting hold of such things!
Faber Fyr (2 years ago)
Church as church
Lisbeth Hamilton (2 years ago)
Pleasantly surprised so beautiful church and chapel lay in a beautiful valley
mohannad nader (2 years ago)
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Photo from Flickr, copyright yashima
Historic Site of the week
Quimper Cathedral
From 1239, Raynaud, the Bishop of Quimper, decided on the building of a new chancel destined to replace that of the Romanesque era. He therefore started, in the far west, the construction of a great Gothic cathedral which would inspire cathedral reconstructions in the Ile de France and would in turn become a place of experimentation from where would later appear ideas adopted by the whole of lower Brittany. The date of 1239 marks the Bishop's decision and does not imply an immediate start to construction. Observation of the pillar profiles, their bases, the canopies, the fitting of the ribbed vaults of the ambulatory or the alignment of the bays leads us to believe, however, that the construction was spread out over time.
The four circular pillars mark the start of the building site, but the four following adopt a lozenge-shaped layout which could indicate a change of project manager. The clumsiness of the vaulted archways of the north ambulatory, the start of the ribbed vaults at the height of the south ambulatory or the choice of the vaults descending in spoke-form from the semi-circle which allows the connection of the axis chapel to the choir – despite the manifest problems of alignment – conveys the hesitancy and diverse influences in the first phase of works which spread out until the start of the 14th century.
At the same time as this facade was built (to which were added the north and south gates) the building of the nave started in the east and would finish by 1460. The nave is made up of six bays with one at the level of the facade towers and flanked by double aisles – one wide and one narrow (split into side chapels) – in an extension of the choir arrangements.
The choir presents four right-hand bays with ambulatory and side chapels. It is extended towards the east of 3-sided chevet which opens onto a semi-circle composed of five chapels and an apsidal chapel of two bays and a flat chevet consecrated to Our Lady.
The three-level elevation with arches, triforium and galleries seems more uniform and expresses anglo-Norman influence in the thickness of the walls (Norman passageway at the gallery level) or the decorative style (heavy mouldings, decorative frieze under the triforium). This building site would have to have been overseen in one shot. Undoubtedly interrupted by the war of Succession (1341-1364) it draws to a close with the building of the lierne vaults (1410) and the fitting of stained-glass windows. Bishop Bertrand de Rosmadec and Duke Jean V, whose coat of arms would decorate these vaults, finished the chancel before starting on the building of the facade and the nave.
Isolated from its environment in the 19th century, the cathedral was – on the contrary – originally very linked to its surroundings. Its site and the orientation of the facade determined traffic flow in the town. Its positioning close to the south walls resulted in particuliarities such as the transfer of the side gates on to the north and south facades of the towers: the southern portal of Saint Catherine served the bishop's gate and the hospital located on the left bank (the current Préfecture) and the north gate was the baptismal porch – a true parish porch with its benches and alcoves for the Apostles' statues turned towards the town, completed by an ossuary (1514).
The west porch finds its natural place between the two towers. The entire aesthetic of these three gates springs from the Flamboyant era: trefoil, curly kale, finials, large gables which cut into the mouldings and balustrades. Pinnacles and recesses embellish the buttresses whilst an entire bestiary appears: monsters, dogs, mysterious figures, gargoyles, and with them a whole imaginary world promoting a religious and political programme. Even though most of the saints statues have disappeared an armorial survives which makes the doors of the cathedral one of the most beautiful heraldic pages imaginable: ducal ermine, the Montfort lion, Duchess Jeanne of France's coat of arms side by side with the arms of the Cornouaille barons with their helmets and crests. One can imagine the impact of this sculpted decor with the colour and gilding which originally completed it.
At the start of the 16th century the construction of the spires was being prepared when building was interrupted, undoubtedly for financial reasons. Small conical roofs were therefore placed on top of the towers. The following centuries were essentially devoted to putting furnishings in place (funeral monuments, altars, statues, organs, pulpit). Note the fire which destroyed the spire of the transept cross in 1620 as well as the ransacking of the cathedral in 1793 when nearly all the furnishings disappeared in a « bonfire of the saints ».
The 19th century would therefore inherit an almost finished but mutilated building and would devote itself to its renovation according to the tastes and theories of the day.
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Using a new engine known as the Crytek Engine, Far Cry has some of the best looking outdoor graphics known in gaming with it?s tropical sunny scenes and it?s nighttime atmospheric knee-high grass sprawling islands. The A.I. of the troops in this game is phenomenal and you?ll realize this as you travel across islands, under mountains, and down rivers of beautifully landscaped scenery. Traversing through kilometers of the huge sprawling maps, along with the difficulty of the game will have players spending many long hours on the single player campaign alone.
Dating back from the original in 1987, this new remake brings all the fun the original offered plus more of well, everything. Pirates definitely has to be one of the most addictive games released in 2004. Alongside some good graphics and hours upon hours of randomly generated quests, add in some ease of use in learning to play, this game is a definite buy for any fan of the original or any gamer who?s looking for a overall fun time. Give this game a try and watch the hours tick by like minutes. Sid Meier, master of strategy games alike brings his talent to another wonderful game.
Virtually two different games allowing the players to control their empire over a turned-based style of play, and then being able to be involved in real-time battles controlling thousands and thousands of troops on one screen alone. Not one game out on the market gives the player the ability to control so many troops, giving them the option to battle with strategic flanking or through diverging different troops against each other capitalizing on certain unit?s weaknesses. Being developed on a new graphics engine that allows each troop to have individual skirmishes with their enemies, this game looks great all around with the single player campaign and also the ability to play seven other people in one giant war. Don?t forget to mention the wonderful musical score to listen to throughout your periods of battle and strategizing and you have a great game all around.
2004 was definitely not a year for Role Playing Games only having the releases of Sacred, Beyond Divinity, and a couple others, but VTMB shines in every way from the very start. Troika released a winning game with the alternate endings, many numerous dialog options corresponding with the vampire clans or situations, and an all around good looking game through the use of the Source Engine licensed from Valve. With the realistic and very atmospheric scene of the World of Darkness, licensed from White Wolf, VTMB is for any gamer whose been waiting the past year or so for a great RPG, because games like this don?t come along too often.
Bursting out onto the pc in August, this remake of the original Doom put the fear back into pc gamers that had been lost from the previous years of lackluster scary First Person Shooters. Doom 3, to put it plainly, had amazing graphics which were fueled by the mind of John Carmack and his computer. The graphics engine with all its features, which with even today?s top computers still can?t be put to their full potential, along with some awesome weapons, gives the player an experience that won?t soon forget. Given only a flashlight for light in the shadowed Mars Station, powerful weapons, related to the originals from the first Doom, provide the player with a sense of calmness while battling hundreds and hundreds of demons and screaming babies through the ravaged Mars station. Although not the best story in a game, this is probably one of the best looking games to date.
Being third in the line of the Thief Series, TDS had a lot to prove and it excelled. Never in a game has the essence of shadows been captured so well. Having both good graphics and a good storyline, TDS leads the player through a single player campaign that easily lasts 20-30 hours unlike many games out this year. Along being able to hide in the shadows, another element of the Thief Series was the use of sound in the game and TDS certainly doesn?t disappoint. Add to that, a decent physics engine and a level/mission in the game that?ll make any player leave the lights on (The Mission ?The Cradle), which can be seen as the scariest level in gaming history, and you?ve got a superb delivery stealth game.
Being released by a new developer in the second quarter of this year, Painkiller brought back the old style gameplay of First Person Shooters like Quake and Serious Sam. Painkiller puts the player through an experience that lasts from the upper regions of Purgatory to the deepest pits of Hell battling the top generals of Lucifer?s army until finally being able to battle Lucifer himself. Having great graphics, good physics, and also some great gameplay, any fan of FPS should pick this game up for a good length single player campaign filled with replay value through Tarot Cards and locked levels. Painkiller also has a unique multiplayer where multiple deathmatches are available with their own special playing style.
Being the sequel to the action/adventure game of last year can be some hard boots to fill, but PoP:WW does so with honor. The developers definitely listened to their fan?s advice giving a longer single player campaign and a more in-depth fighting style for the player to battle the horde of enemies with. Adding a different style of art, a darker tone to the once Arabian atmospheric prince, Warrior Within takes a more edgy stance with the amount of gore and heavy rock music in the game compared to Sands of Time. But, building upon some of the already great enhancements to Sands of Time, Warrior Within is something that all action/adventure games will love.


Some of the chores Patty and I get assigned to around here can be fraught with danger and excitement.
We had been pushing/walking the herd into the home field until these two yahoos decided to go at it. That was my que to back up the buggy and wait and watch at a distance 'til they worked it out or wore themselves out. My hard workin' Patty though, still tried to do her best to keep them moving along.
The reason she and I had the job of moving critters today was to get those bad boys close to the sorting pen so they can be loaded up and taken to market. It's time for them to go down the road after a few good years of fathering a number of great calves. A bull's productive life on our ranch runs an average of five years. They have a good life with us…well-fed, pampered and never given too many "girls" to over-work themselves. Their "working" season runs from July to September. Otherwise they only have to graze, rest and sun themselves under the great big beautiful Alberta sky. Trouble is, when they get to the end of their years with us, they seem to get cranky and pick fights all too easily with each other.
And now the day has come to say farewell to these two…it's definitely time…they've crashed through a pen and tore up a fence in recent days. I'm quite ready to say good-bye.
Although I say that now, when it comes to loading them onto that trailer, I know I'll be a bit sad. I always am whenever my animals are taken from the yard for the last time.
The joy of watching puddles form in the yard and our laneways. Even my border collie can share in the enjoyment of puddles.
Puddles are the finest confirmation that we're getting significant rain fall and we may also soon be enjoying a hay crop and plentiful pastures.
There is one special character on this ranch who lives with unwavering faith and reason to believe that I will daily emerge from the house so she can follow me around the yard and fields as my loving companion. That would be my 14 year old border collie Dixie.
She's pretty stiff with arthritis, she can't hear a thing but she wakes up every day, makes her way to the end of lane and there she waits and watches. She watches the window with every reason to believe that I will wave to her from the window, or even better, emerge through the door all suited up in coveralls – ready to chore with her by my side.
I feel somewhat honoured too that it's me she waits for at the end of the lane. My husband will leave the house earlier than me and head to the barn and corrals with the younger dog but Dixie remains. She remains at the end of the lane and watches and waits with every reason to believe.


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Get Ready For The 4K UHD STAR WARS Saga Box Set
If you like shopping at Best Buy.
By Andrew Todd Feb. 19, 2020
Somewhat unsurprising news, Star Wars fans: The Rise of Skywalker is coming to home video next month! The film that, according to Lucasfilm, "electrified audiences around the globe" (which is true, in a couple ways), will hit all the formats you could possibly want, rolling out starting about a month from now. There will be retail-chain-specific special editions. There will be unwarranted quantities of Palpatine. There will be the following special features:
The Skywalker Legacy – The story lives forever in this feature-length documentary that charts the making of Star Wars: The Rise of Skywalker.
Pasaana Pursuit: Creating the Speeder Chase – Dive into the making of the movie's epic landspeeder chase and discover how this spectacular sequence was brought to the screen.
Aliens in the Desert – See what it took to create the Pasaana desert scenes, from the sheer scale and complexity of the shoot to its colorful details.
D-O: Key to the Past – Explore the ship that connects Rey to the mystery of her missing parents and get to know the galaxy's newest, irresistible droid.
Warwick & Son – Warwick Davis, who played Wicket in Star Wars: Return of the Jedi, dons the Ewok costume once more; this time joined by his son Harrison.
Cast of Creatures – The team behind the film's memorable creatures reveal the puppetry, makeup, prosthetics and digital magic that bring them to life!
Digital Exclusive: The Maestro's Finale – Composer John Williams reflects on his body of work for the Star Wars saga and shares insights on scoring Star Wars: The Rise of Skywalker.
Any potential juice in this release is sure to be found in that feature-length doc, but I'm skeptical that it'll explore the full development process, which is what we actually want to know about. Also: we're calling it Star Wars: Return of the Jedi now? Okay.
Here's a trailer, which is spoilery if you haven't seen the movie, and possibly traumatic if you have:
The more interesting news to collectors, however, is that the movie will also be included in the also newly-announced Skywalker Saga 4K UHD box set. Containing 27 discs (at least 18 of which are simply the 4K and Blu-Ray copies of the films), it's the first time the films have been physically released on 4K. Here's hoping their upscaling technology works well, because Episodes II and III were shot in regular-ass digital HD, baby.
The promotional image refers to it as a "limited edition," and given the wide range of uses of that term, it's unclear what exactly it means. From all appearances, though, this seems to be just a 4K release of the movies (hopefully with the Atmos mixes found on Disney+); bonus material appears to be the same found on the Blu-Ray releases. These are also almost certain to be the current bajillionth-generation special editions of the films; the mythical release of the original trilogy in its original form becomes more of a myth with each passing year.
Oh, and the 4K set is a Best Buy exclusive in the US, and an Amazon exclusive in the UK. Amazon UK has a Blu-Ray only complete set listed too, but that's not the new thing, is it?
Is it just me, or does this all seem kind of undramatic? The DVD and Blu-Ray releases of the Star Wars films were big deals, but 4K just isn't as inspiring a jump in quality (or as common in homes). Add to that the lack of announced bonus features, the oversaturation of Star Wars recently, the disappointing final entry in the saga, the retail-chain exclusivity, and the fact that these 4K versions have been viewable on Disney+ for several months, and you've got a pretty lacklustre obligation buy. Then again, at this point we're lucky to get physical releases at all.
The Rise of Skywalker hits digital formats on March 17, and physical media on March 25; the box set drops on March 31, if you can get it.
Star Wars Dot Com
Can THE MANDALORIAN Redeem Boba Fett?
Can anyone?
Live-Action Bo-Katan Boards The MANDALORIAN In The Form Of Katee Sackhoff
Look, are they going to bring Chopper into this thing or what?
Temuera Morrison & Boba Fett Return To STAR WARS
Thank THE MANDALORIAN season two, where all STAR WARS fan dreams come true.


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camden, chalk farm, hampstead, primrose hill & kentish town
CAMDEN, NW1
World famous Camden Town is a tourist haven, particularly at weekends when Camden Lock and the indoor and outdoor markets are packed with visitors. But there are also plenty of quiet places away from the crowds and tourist tat.
Camden Town has lots of trendy pubs, bars and nightclubs, along with fashionable cafes and restaurants, as well as open green spaces at nearby Primrose Hill, Regent's Park and Hampstead Heath. It is also a prime destination for music gigs, particularly as far as indie music is concerned, with established venues such as the legendary Jazz Café and Barfly.
Camden varies enormously, with a plethora of ex-local authority homes dominating the southern part of town, while there are lots of Victorian and Georgian houses, many of which have been converted into flats, in the north.
Camden Town and Mornington Crescent (both Northern Line, Zone 2), along with Camden Road (London Overground, Zone 2) offer easy access to central London, as do the high number of 24-hour bus services that operate in the area.
CHALK FARM, NW5
Situated directly to the north of Camden Town is Chalk Farm, a short walk from affluent Primrose Hill. Much like Camden, the area attracts revellers from all walks of life, due to its lively pubs, restaurants and live music venues, including the world famous Roundhouse.
Whether a Georgian house or a Victorian conversion, homes released onto the market in Chalk Farm are often snapped up within a very short space of time. This buzzing neighbourhood is popular with a variety of homebuyers and renters, particularly young professionals attracted by the good local transport links who are seeking an easy commute into town.
The nearest tube station is Chalk Farm (Northern Line, Zone 2), while there are plenty of 24-hour bus services in the area along with neighbouring Camden, five minutes south.
HAMPSTEAD, NW3
Located in the London Borough of Camden, Hampstead is an affluent area, reflected by reports that its village is home to more millionaires within its boundaries than any other area of the United Kingdom.
There is plenty to see and do in Hampstead. You can discover Hampstead's great restaurants, bars and pubs, or simply take a stroll over Hampstead Heath or explore the area's upmarket boutiques.
Hampstead High Street consists of a wide selection of ladies' and men's fashion outlets alongside some of the better-known quality brands, including Reiss, Whistles, Hobbs, Kurt Geiger, Trilogy, Nicole Farhi and Jaeger.
Hampstead High Street is also home to an unbeatable range of independent butchers, fishmongers, bakers, health and beauty, florists, art galleries, home ware, gifts and book shops.
Unsurprisingly, Hampstead is one of the most sought-after areas of London in which to live, reflected by high property and rent prices. The district features a range of property types, including large Edwardian houses and Victorian terraces, as well as small cottages, purpose-built flats, mews houses and mansion blocks.
The area is well served by good transport links; Tube links include Hampstead and Belsize Park (both on the Northern Line, Zone 2), while Hampstead Heath and Gospel Oak stations are on the London Overground Line, Zone 2. The area is also well served by a wide selection of buses, offering good links to other parts of the capital.
KENTISH TOWN, NW5
Neighbouring Highgate and Hampstead, Kentish Town is growing increasingly sought-after, especially among middle class professionals.
This contemporary neighbourhood is home to a wide variety of shops, cafes, bars and restaurants to suit all tastes. There is also a local library, snooker hall and a street market nearby at Queen's Crescent.
Avid walkers will love Parliament Fields, which aside from open green space, also offers access to a public outdoor swimming pool, tennis, bowls and a running track.
Kentish Town is a mixed area consisting of a variety of homes, from graceful Victorian homes and four-storey houses to small villas and ex-council housing offering good value for money and a respectable sense of community.
Kentish Town (Northern Line and Capital Connect, Zone 2) and Kentish Town West (London Overground, Zone 2) provide good transport links, along with frequent buses, including a 24-hour service.
PRIMROSE HILL, NW1 & NW8
Located a stone's throw from Camden Town and Chalk Farm, lies the delightfully picturesque village of Primrose Hill, home to the rich and famous and its public park, which gives the place its name.
Primrose Hill (the park), which offers some of the most striking views across London's skyline including many of its famous landmarks, attracts residents and visitors from all walks of life. Regent's Park and Regent's Canal are located nearby, as is London Zoo.
Primrose Hill, which retains many of its original features, is a quiet area, packed with fashionable cafes, restaurants and pubs, particularly in the main village. There is also a good selection of independent fashion boutiques, most of which are situated on one main high street, along with specialist shops offering organic products.
The general shortage of properties in Primrose Hill has left estate agents in the area crying out for more housing stock to meet strong demand from people looking to buy or rent property in the area.
Despite some new-build homes, the area is dominated by larger, older-style properties on wide tree-lined streets, including some of the most beautifully coloured houses and flats in London; from multi-storey stucco-fronted houses and Victorian terraces, to large converted and purpose-built apartments.
The nearest Tube stations are Chalk Farm and Camden Town (both Northern Line, Zone 2), while the area is also well served by 24-hour bus services in nearby Chalk Farm and Camden Town.
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The Holidays are rough for some of us. This time of year emotions slip the slopes of the heart, tearing a salty avalanche down cheek-side.
Yup – we all a have valid reasons to be sad – But I have found a perfect elixir for your woe.
This week my heart grew a bigger with joy at The Gala at Citi Performing Arts Center - which doubled as a Celebration of Josiah 'Joe" Spaulding's 25 years at the helm.
As we inch through these Daze – which can be so emotionally challenging - I think of choices. You could sulk in your cave all "grinchIfied" or you could use that instant to simply holler a thank through the telephone line / or on social media / better yet – grab your stamps and start writing a letter.
And while I am urging you to do it – I am 'about to grab a few stamps myself – because I am waaaay behind in my Thank You time.


There are many ways to celebrate the bicycle and its impact during the month of May: by organizing a successful event, educating your community, learning how to fund-raise, building partnerships and more (go to bikeleague.org). Here, let's narrow our focus, for the sake of space, to the third Friday of May—Bike-to-Work Day. What can you do to participate—and to get others to join in?
ASK AROUND Paste this message into an e-mail and send it to coworkers who might be interested: "Hey all, I'm riding my bike to the office on Friday. If you'd like to join, let's come up with a plan. If your route will be different from mine, maybe you can organize your own group. We can all meet for breakfast at the diner near the office. Who's in?"
REMEMBER THE CHILDREN Anyone with kids knows that the freedom to hop onto a bicycle at leisure disappeared when the doc said "Congratulations. It's a boy." If you can find a safe route to pedal with your child—whether you're hauling him or he's riding on his own—share it with other parents who might be interested in forming a convoy.
SHOW THE WAY Map out a few routes to the office from various directions and post them at work. If you get just one person to change his or her mind about riding in, you've done your job.
YEAH, BUT... Inevitably, some people will find a reason why they couldn't possibly commute by bike—out of shape, too far away, rain, no showers at work, beater bike. Arm yourself with solutions, then remind them that it's just one day.


"Commerce is tough. Commerce is all about maths. Commerce is only for bright students." – Do you have these thoughts? Are you struggling to decide if you should take up Commerce Stream for higher studies? Students enrolling for admissions now have to make the difficult decision on which stream to pursue – Arts (Humanities), Science or Commerce. When it comes to Commerce, there are many preconceived notions and myths about the difficulty and popularity of the subject. Learn more about the subject as Lekokonen, Asst. Prof. from the Commerce Department, shares from his own personal experience on how and why he chose commerce.
When I chose commerce as my subject of study, I was not aware of what commerce was all about. Maybe because at that time it was not a very popular subject in our State.
When I was in class 7, our mathematics teacher asked our class which stream we would like to pursue in future. Some replied arts and others science. I simply replied science mainly because my friends chose the same. Afterwards, I began to wonder why none of my classmates opted for commerce as a career choice. So one day I asked my friends why people usually did not prefer commerce. Some replied it is hard and others replied only brilliant students go for it. This conversation affected me deeply and challenged me to firmly decide to take up commerce as my choice of study. I always wanted to be different from others. Now when I recall their answers, I should say that they were quite ignorant. I thought hard and made a quick decision.
So it turned out that I took up commerce as my subject because none of my friends preferred it. However, this also increased my curiosity to know what commerce is all about and what made people fear taking it up as a subject of study. Moreover I loved mathematics and I heard that commerce is usually concerned with mathematics. So, when I shared my thoughts with my parents and relatives, they were so shocked and asked me what aim I had that made me pursue it. I didn't reply anything at that time and instead tried my best to avoid them. To be honest I didn't have any aim at that time.
I blindly joined commerce, quite aimless and with great fear. At first, I found it difficult to learn the subject because it was different from what I expected. I thought it would be purely based on mathematics.
It was only after I joined this stream that I became aware of the abundant career opportunities. I also learned that there was much more packed inside the meaning of "commerce" as a subject of study, which many of us are not aware of, unless the concept is broken down and taken up individually.
Very soon, I started loving the subject. I figured out that being a commerce student has its own personal advantages too, as the study provides an idea on how to achieve greater financial security and hence a secure future. Of course, it does not come that easily. Like the science stream, the student also needs to have a certain aptitude and put in a lot of hard work in this field of study to reap the entire benefits.
The important thing is to not let our socio-cultural environment or our narrow mindset inhibit our hidden potential. After taking it up as my subject, I realized there was nothing too tough or hard and absolutely nothing to fear in studying commerce. My initial fears about commerce were brought on because of the mindset I had been made to believe.
While pursuing the study of commerce, I acquired knowledge of business and trade, nature and fluctuation in market, basics of economics, fiscal policies, industrial policies etc. I also learned that the concept of commerce consists of a wide range of interdisciplinary branches including accountancy, business administration, E-commerce, finance, economics and marketing etc. My initial understanding of commerce as mostly dealing with mathematics was quite different from what commerce actually is.
Commerce is a versatile subject with many other professional diploma, degree courses and career options available to the student after Class 12. Some of them are B.Com, BBA, BMS BBM,CA, ICWAI etc. Career options include banking, management, accountancy or private enterprise etc.
Today, the importance of commerce has increased manifold, its subject knowledge indispensible to every field and profession. As a teacher of commerce my advice is that we sometimes need to go beyond our comfort zone to grab the opportunities before us and fulfill our dreams. No subject is hard if you work hard at it. My own experience of choosing commerce has taught me this. Taking up commerce as my subject was my own decision, and I am glad and grateful that I made the right decision.
Commerce. I am trying to find out what this noun means to me exactly. Could you tell me the growth prospects in this field? Is the growth fast? Or are the career oppurtunities more on the static side?


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Mahindra Q4 Profit Jumps 14.4% On Better UV, Tractor Sales
May 30,2016 Press Trust of India Read News PRINT
May 30,2016 Press Trust of India Read News
JLR India launches the all new XE at Rs 39.90 lakh. Photo: Twitter Tata Motors Ace Mega Tata Motors reported a stellar set of numbers for the March quarter. Strong sales growth of Jaguar Land Rover (JLR) across geographies and robust commercial vehicle growth in the domestic market led to a 19% year-on-year consolidated revenue growth at Rs 80,684 crore in the March 2016 quarter. The company's consolidated profit after tax for the quarter grew 201% to ₹5,177 crore year-on-year.
The auto major's stronger operating performance both in standalone as well as Jaguar Land Rover business and lower net finance expenses were partly offset by higher depreciation and amortisation expenses, adverse revaluation of euro payables and one-time charges of ₹1,580 crore (£166 million).
This was due to an industry-wide recall in the US of potentially faulty airbags supplied by Takata, doubtful debts and previously capitalised investment in the Jaguar Land Rover business.
For the financial year 2015-16, Tata Motors clocked consolidated revenues of ₹2,75,561 crore against ₹2,63,159 crore for the corresponding period last year. After exceptional items, consolidated profit after tax for the fiscal year was down 21% to Rs 11,024 crore.
However, the year has been an eventful one for JLR and there have been a several exceptional items.
However, JLR put up an unexpectedly strong show during the quarter. JLR's operating margin came in at 16.2% in the March quarter against 14.4% it reported in the December quarter.
Analysts claim that the margins have rebounded due to the positive operating leverage and improving demand in China helped. JLR's profit after tax jumped 56% to £472 million during the March quarter. Revenues for the quarter rose 13.5% year on year to to £6,594 million.
"We are investing £3.8 billion this year in new capacity addition, product development and meeting other engineering costs as far as JLR is concerned," said Ralph Speth, CEO, JLR. The standalone business too reported healthy growth. Revenues grew by 17% y-o-y to Rs 12,569 crore.
Sales growth was driven by a 26.6% y-o-y spurt in volumes of medium and heavy commercial vehicles during the quarter on the back of the continued replacement demand, initial fleet expansion demand, infrastructure spending and better profitability of the freight operators.
Light commercial vehicles also reported a volume growth of 11.8% y-o-y during the quarter. The standalone business EBITDA margin stood at 8.1% against estimates of 6.7%. Margins in the domestic business expanded as raw material costs declined 400 basis points sequentially. The operating income of the standalone business came in at Rs 1,021 crore, which again is well ahead of estimates.
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