With up to 400,000 Australians living with dementia and the number rising rapidly as Australia's 'Baby Boomers' pass the age of 65, the symptoms of dementia may be something to look out for, especially if the person you are caring for is starting to show some different or unusual behaviours.
While it's helpful recognise signs of dementia, such as increased forgetfulness or changes in the person's usual disposition or behaviour, it's especially important to take proactive steps to reduce the risk of the disease.
Staying physically active can lower the risk of heart disease and stroke, which are conditions known to increase the risk of developing dementia. Australia's Physical Activity and Sedentary Behaviour Guidelines for Adults suggests seniors only need 30 minutes of moderate intensity activity a day to improve their health.
Going to the theatre, museum or concert.
It's also important to note that good self-care means getting the right amount of rest. Sleep improves neuroplasticity (the ability to of the brain to re-wire itself), according to Aged Care Insite, so plan to have a good night's sleep by creating a routine around going to bed. Close the curtains or blinds, turn off laptops, phones and iPads at least an hour before you intend to retire, and have a shower and warm drink to relax yourself!
Seven to eight hours of sleep a night is recommended, but this can vary between individuals.
Social stimulation can help fight loneliness - which is thought to contribute to cognitive decline. In fact, research findings indicate the health impact of loneliness and lack of social connections is equivalent to smoking 15 cigarettes a day (Holt-Lunstad, 2015).
Low levels of social stimulation can also contribute to an increased risk of dementia. Research suggests that social connectedness supports brain plasticity and helps to maintain cognitive reserve.
Social connectedness can also help to lower blood pressure. High blood pressure can contribute to poor memory, so the right environment with friends and family can reduce the stress and anxiety that are often contributing factors to decline.
Unsaturated fats e.g. olive or canola oil.
As we age the body is less able to process alcohol, therefore a maximum of 1-2 drinks per day is recommended to reduce the risk of dementia. Regular dental checkups are also an important part of a health care plan, as poor oral health can lead to malnutrition, a common finding in dementia.


Triathlons, also know as Ironman competitions, are becoming increasingly popular for both men and women. Whether an amateur or a professional, the correct clothing is essential.
With a triathlon event, the competitor needs to ensure that they choose the correct clothing so that they may achieve their sporting goals. As there are so many pieces of clothing for a triathlete to purchase, products should be a reasonable price. The clothing purchased should enhance training and performance.
Tri suits are becoming an important piece of clothing for a triathlon, keeping competitors warm during the swimming stage. A tri suit then also gives unrestricted movement during cycling and running stages. Tri suits are made of material which is suitable to swim in and it dries out fast. More expensive tri suits are designed to wick away sweat.
Traditionally, two piece top and shorts sets were worn for a triathlon. These are now only worn by the athletes who feel restricted in an all in one tri suit. The two piece does give the wearer more flexibility and allows them to be marginally cooler in hot weather.
Whether choosing a single suit or a two-piece, the clothing always needs to be tight fitting. This way, the clothing will keep its shape during the swimming stage and not be loose during the cycling event. Nevertheless, they should not be too tight so as to affect the athletes' breathing. Wind jackets can also be purchased to give extra warmth during the cycling and running stages.
When competing in the cycling element of a triathlon, it is important that a visor is worn to protect eyes from the sun or wet weather. During this stage of the competition, footwear is an important consideration. It is important that the correct footwear is chosen to give ultimate ventilation and fast transitions between the different elements. When cycling, grip on the handlebars is also very important. Hands may be cold and wet after the swim. Ridge gloves are an ideal solution. Helmets are an important aspect of triathlon clothing. Helmets are now being designed to be lightweight and comfortable. The addition of air vents on top of the helmet ensures the wearers head does not get too hot and allows cool circulation.
As the name suggests, Ironman was predominantly a male sport. However, more and more women are becoming increasing interested in the event and as a result, there are companies who specialise in providing clothing and advice to women.
It is very important that the correct clothing is chosen for a triathlon event. Fusion provide a full range of cycling clothing providing comfort, durability and protection in all weather conditions. Full triathlon clothing has been specially developed to enhance the performance and comfort of triathletes at all levels. Compression products are a new, innovative idea. They are designed to enhance performance by reducing muscle vibration whilst increasing accuracy and efficiency of movement. A lot of research has gone into developing products to offer comfort and support for all training activities.


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Q: Python: Detect a rare strange GIF when extracting its frames I have collected a large-scale datasets of gifs(more than 100k) from the Internet, and I meet some rare strange GIFs when I try to extract frames of GIFs with python. Three common used packages(moviepy, PIL, imageio) provide totally different results of such rare strange gifs.

*

*moviepy>=1.0.3 will block in VideoFileClip.iter_frames() loop at the second frame forever, and the code won't throw an exception.

from moviepy.video.io.VideoFileClip import VideoFileClip

video = VideoFileClip(path)
frame_iterator = video.iter_frames()

*PIL>=7.1.2 will output multiple frames as same as the first frame.

from PIL import Image, ImageSequence
from PIL import ImageFile
ImageFile.LOAD_TRUNCATED_IMAGES = True

video = Image.open(path)
frame_iterator = ImageSequence.Iterator(video)

*imageio>=2.6.1 can extract the frames correctly while the output frames are strange.

import imageio

frame_iterator = imageio.get_reader(path)

Then you can dump the frames from frame_iterator provided by these packages above:
def dump_video_frames(video_frames):
    root = 'data/frames'
    if os.path.exists(root):
        shutil.rmtree(root)
    os.makedirs(root)

    for i, frame in enumerate(video_frames):
        frame.save(os.path.join(root, '%d.jpg' % i))

frames = []
for frame in frame_iterator:
    if isinstance(frame, np.ndarray):
        frame = Image.fromarray(np.uint8(frame))
    frames.append(frame.convert('RGB'))

dump_video_frames(frames)

Here is an example:
Original GIF:

The output of PIL:

The output of imageio:

You can see PIL only get the first frame without any black area which is quite different with the output of imageio.
So my question is how to detect such a strange gif in python? Since I use moviepy first for its good performance in other gifs, I need to detect such a kind of GIF before the code use moviepy to extract its frames in order to avoid the infinite loop in VideoFileClip.iter_frames() which won't throw any exception. I can't get any information about such a rare gif from Google.
I will provide 2 more example GIFs below:

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text:
Patrick Bauchau
View cart "The Boarder (2014)" has been added to your cart.
Amnesiac (2015)
The story of a man who wakes up in bed suffering from memory loss after being in an accident, only to begin to suspect that his wife may not be his real wife and that a web of lies and deceit deepen inside the house where he soon finds himself a prisoner.
Phenomena DVD 1986 (Original)
A young girl, with an amazing ability to communicate with insects, is transferred to an exclusive Swiss boarding school, where her unusual capability might help solve a string of murders.
Phenomena Blu-Ray 1986 (Original)
Lisbon Story DVD 1994 (Original)
Lisbon Story is Wim Wender's homage to Lisbon and films. A sound engineer obtains a mysterous postcard of a friend who at the moment is filming a film in Lisbon. He sets out across Europe to find him and help him.
The Boarder (2014)
Inspired by true-life events, this is the sobering story of the Williams family and their process of coping with an adopted child suffering from Reactive Attachment Disorder.
First Desires (1983)
Three teenage girls decide to visit a romantic island and find love. They get shipwrecked and end up on different sides of the island. Each girl begins her own romantic adventure either with a man, a boy or even another girl.
We Free Kings (1996)
Three tumblers wander throughout Italy with their show. A priest asks them to perform the Three Kings in a Nativity play, in a village where there are no children. That night a comet runs across the sky, so the three decide to follow it to search for the new Messiah.
The Pretender is an American television series that aired on NBC from 1996 to 2000. The series starred Michael T. Weiss as Jarod, a genius and former child prodigy with the ability to become anyone he wants to be, i.e., to flawlessly impersonate anyone in virtually any line of work. Patrick Bauchau and Andrea Parker co-starred as Sydney, Jarod's childhood teacher and mentor, and Miss Parker, a childhood friend. They are both operatives for a mysterious organization called "The Centre", which took Jarod from his parents as a child and developed his special talents with the intention of making him one of their agents, while also using his brilliant intellect for their own evil purposes. After escaping from their custody, Jarod begins traveling the country, searching for clues to his true identity while posing as a doctor, police officer, attorney, or some other character who helps those in trouble. The Centre's directors are determined to return Jarod to The Centre to further their mysterious plan. A team of operatives, led by Miss Parker, attempts to find and capture The Pretender. Jarod's extreme intelligence combined with his childlike innocence create a memorable and endearing character that was popular with viewers.
The New Age (1994)
Peter and Katherine Witner are Southern California super-yuppies with great jobs but no center to their lives. When they both lose their jobs and begin marital infidelities, their solution is to start their own business together. In order to find meaning to their empty lives, they follow various New Age gurus and other such groups. Eventually, they hit rock bottom and have make some hard decisions
The Gray Man (2007)
Early 20th century. Albert Fish, a seemingly benevolent father and grandfather who reared his family by himself after his wife deserted them, turns out to be a serial child molester and murderer. Based on a true story.
Boy Culture (2007)
A successful male escort describes in a series of confessions his tangled romantic relationships with his two roommates and an older, enigmatic male client.
Kindred: The Embraced
Kindred: The Embraced is an American television series produced by John Leekley Productions and Spelling Television. Loosely based on the role-playing game Vampire: The Masquerade, the series premiered on Fox on April 2, 1996, and ran for eight episodes before it was canceled on May 9, 1996.
The series focused on San Francisco Police Detective Frank Kohanek who discovers his city is home to numerous vampires while investigating alleged mobster, Julian Luna. Julian is the "prince" of the city, ruler of five groups of vampires in the city, collectively called "The Kindred". The vampires survive through the "masquerade", disguising themselves as humans, and Julian strictly enforces the laws that govern them to protect their anonymity. Julian and Frank form an uneasy bond as they work together to try to prevent a vampire war and Julian struggles with his romantic feelings for human reporter Caitlin Byrne.
The eight episodes of the series have been released on VHS and DVD.

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Bill Clark is a British movie maker. His recent Writing and Directing credits include the feature films Starfish and "The Christmas Miracle of Jonathan Toomey", which was chosen for Ibiza, Boston, Edmonton, Heart of Gold Film 2007 Festivals, and was Winner Best Film, Salt Lake City Film 2007 Festival. He makes documentaries and, commercials for which he has 600+ credits. His current experience also includes Creative director for Smyths Toy Store Group. His work includes Director of Films and industrial theatre shows for major international companies. His pop promos, music business work, photography and art direction credits include Slade, Kate Bush, Pink Floyd, The Hollies, Cliff Richard, Olivia Newton-John, Def Leppard, Soul II Soul, Leonard Bernstein, Sir Georg Solti, Lynn Anderson, and Elton John. He was Festival Director Stamford Children's film festival 2010, Guest lecturer, Film & Video at York University, 2009, 2010, Lecturer Anglia Ruskin University Film & Video module 2010.


text:
SYMHM: A Trump Hotel, A Coffee Bean, a Vote for FAIR Girls
by Borderstan.com February 8, 2012 at 8:00 am 1,783 2 Comments
Borderstan.com covers DC's Dupont, Logan and U Street neighborhoods.
By Michelle Lancaster. Got news, a hot tip or want to complain about what is or isn't in this? Let her know on Twitter @michlancaster or via email at [email protected].
Old Post Office to Become Trump Hotel
In a move that is already causing shock waves through DC, the General Services Administration selected a proposal from Trump Hotels (yes, that Trump) to redevelop the Old Post Office. The The Washington Post reports that, despite its listing on the National Register of Historical Places, the property was deemed under-utilized.
The plans from the Trumps call for a luxury hotel, "on par with the Plaza in New York" at the historic location, which maintains the historic facade and details inside.
The property now loses over $6 million a year, despite its tony address and one of the best roof views in DC. Plans for the bell tower and public roof access have yet to be released.
More Info on Coffee Bean & Tea Leaf
You may have heard that California chain Coffee Bean & Tea Leaf will make its debut in DC soon. The store will open in February (soon) in the Washington Hilton, says the Washington Business Journal. Expect free wi-fi, baked goods and plenty of conference attendees in the building better known to long time Borderstanis as the Hinckley Hilton.
Local Non-Profit Gets National Recognition
Have you been meaning to volunteer in 2012 and have yet to make it out of your house? While you should still pursue that goal, you can do a good deed for a local non-profit that is doing a load of good for girls across the globe. So go vote for Andrea Powell as one of Diane Von Furstenberg's Awards nominees (blonde, right center). She is the executive director of FAIR Girls, which offers empowerment and education to girls in perilous situations.
FAIR Girls runs several programs, including one-on-one counseling for victims of sex trafficking, compassionate care, education and empowerment, that benefit young girls and women in DC, across the US, Bosnia, Serbia, Uganda, Russia and so on. Get involved with them here and be sure to vote today.
Coffee Bean & Tea Leaf, DC Old Post Office, Donald Trump, FAIR Girls, Old Post Office


The SRPK category of kinases regulates pre-mRNA splicing by phosphorylating serine/arginine (SR)-rich splicing factors, signals splicing control in response to extracellular stimuli, and plays a part in tumorigenesis, suggesting these splicing kinases are potential therapeutic targets. for treatment of age-related macular degeneration. In Short Hatcher et al. statement the 1st irreversible SRPK1/2 inhibitor SRPKIN-1, which inhibits phosphorylation of serine/arginine (SR)-wealthy splicing elements proteins and induces a VEGF alternate splicing isoform change, resulting in anti-angiogenesis inside a damp CNV mouse model. Open up in another window INTRODUCTION Alternate pre-mRNA splicing in eukaryotic cells is definitely a prevalent procedure for growing the transcriptome difficulty and proteome variety, which is vital for keeping both mobile and cells homeostasis. This technique is catalyzed with a complicated cellular machine referred to as the spliceosome, which comprises five little ribonucleoproteins and several proteins co-factors (Wahl et al., 2009). Included in this, the category of serine/arginine (SR)-wealthy splicing elements is involved with both constitutive and controlled splicing (Zhou and Fu, 2013), and their actions are controlled by many serine/threonine kinases. The 1st identified SR proteins kinase is definitely SRPK1 (Gui et al., 1994a, 1994b), which is definitely conserved from candida to human beings (Siebel et al., 1999). The human being genome encodes three WAY-100635 maleate salt manufacture SRPK genes, and SRPK1 continues to be detected in lots of human cells, at varying degrees of manifestation, while SRPK2 and SRPK3 show tissue-specific manifestation in neurons and muscle tissue, respectively (Wang et al., 1998; Nakagawa et al., 2005). In cells, most SRPK1 is definitely WAY-100635 maleate salt manufacture localized in the cytoplasm where it catalyzes SR proteins phosphorylation to facilitate their nuclear transportation (Kataoka et al., 1999; Lai et al., 2001; Zhong et al., 2009), which process is definitely accelerated in response to extracellular stimuli (Nowak et al., 2010). Once in the nucleus, SRPK1 can synergize with extra SR proteins kinases, like the CLK category of kinases mainly localized in the nucleus, to help expand phosphorylate SR protein to market spliceosome set up (Aubol et al., 2016). During splicing, SR protein become dephosphorylated by nuclear phosphatases, and like the majority of phosphorylation-regulated protein, SR protein are controlled via this phosphorylation-dephosphorylation routine in different mobile compartments (Misteli et al., 1998; Ngo et al., 2005; Huang and Steitz, 2001; Huang et al., 2003; Sanford et al., 2004). This extremely co-ordinated process is vital for advancement and disease (Wang and Cooper, 2007; Cooper et al., 2009). Certainly, misregulation of SRPK1 appearance induces a lot of aberrant substitute splicing occasions. In breast, digestive tract, lung, prostate, and pancreatic cancers, for example, raised SRPK1 amounts are functionally associated with cell proliferation, migration, and trafficking, aswell as angiogenesis and chemotherapy-induced level of resistance (Hayes et al., 2007; Gout et al., 2012; Mavrou et al., 2015). While cancer-associated splicing applications are likely controlled via a selection of systems, some particular regulatory pathways have already been well defined. For instance, the enhanced creation from the angiogenic isoform of vascular endothelial development factor (VEGF) caused by SRPK1 overexpression is definitely a definite exemplory case of how splicing can effect disease development (Amin et al., 2011; Gammons et al., 2014). Angiogenesis, a natural process of fresh blood vessel development, is crucial for tumor development, inflammatory disorders, and intraocular neovascular illnesses. VEGF is an integral regulator of angiogenesis through the activation of its cell surface area receptor VEGF receptor (VEGFR), resulting in endothelial cell proliferation. As an positively pursued therapeutic focus on, various small-molecule VEGFR inhibitors have already been reported (Ivy et al., 2009). Nevertheless, most Meals and Medication Administration (FDA)-authorized VEGFR inhibitors are pan-receptor WAY-100635 maleate salt manufacture tyrosine kinase (RTK) inhibitors, and creating a selective VEGFR inhibitor is a problem. Inhibition of VEGF signaling having a pan-VEGFR inhibitor offers been proven to trigger dose-dependent mobile toxicity (Richards, 2011; Duda et Rabbit polyclonal to ZNF200 al., 2007). While focusing on VEGF with little molecules offers proven difficult, the usage of VEGF-blocking antibodies such as for example Ranibizumab continues to be successfully utilized for dealing with age-related macular degeneration (AMD) (Rosenfeld et al., 2006; Gragoudas et al., 2004), an intraocular neovascularization disease due to abnormal development of arteries inside the eyes (Seddon and Chen, 2004). Nevertheless, antibody-based therapy is normally often connected with multiple risk elements, including infection, irritation, and vitreous hemorrhage (Shima et al., WAY-100635 maleate salt manufacture 2008; Ventrice et al., 2013). As a result, small-molecule inhibitors stay desirable for sufferers with AMD and cancers, either being a monotherapy or in conjunction with other anti-cancer realtors. Instead of preventing VEGFR, a different strategy is normally to exploit its ligand VEGF.


text:
info@headlinebooking.com
Browse Entertainers
Pop & Disco
Booking Grace Jones
To book Grace Jones for your next event, please fill in the form to the right. One of our booking agents will reply within 24 hours.
The staff of Headline Booking Group will work with you to produce a memorable event. Get started now by filling out our no-obligation Artist Request Form and we will work with you to book Grace Jones or another artist for your event.
Grace Jones' Biography
Grace Jones secured a record deal with Island Records in 1977, which resulted in a string of dance-club hits. In the late 1970s, she adapted the emerging New Wave music style and adopted a severe, androgynous look with square-cut hair and angular, padded clothes. In 1981, her 'Pull Up to the Bumper' spent seven weeks at #2 on the U.S. Hot Dance Club Play chart, and became a Top 5 single on the U.S. R&B chart.[2] Although she has yet to become a truly mainstream recording artist, in the United States, much of Jones's musical output is very popular in American clubs as many of the singles were hits on Billboard's Hot Dance Club Play and Hot Dance Airplay charts.
EXPAND FULL BIO
Jones was able to find mainstream success in Europe, particularly the United Kingdom, scoring a number of Top 40 entries on the UK Singles Chart. Jones's most notable albums are Warm Leatherette, Nightclubbing and Slave to the Rhythm, while her biggest hits (other than 'Pull Up to the Bumper') are 'I've Seen That Face Before (Libertango)', 'Private Life', 'Slave to the Rhythm' and 'I'm Not Perfect (But I'm Perfect for You)'. During the 1970s, she also became a muse to Andy Warhol, who photographed her extensively.[3][4] During this era she regularly went to the New York City nightclub Studio 54. Jones' is a capable actress and her acting occasionally overshadowed her musical output in America; but not in Europe, where her profile as a recording artist, was much higher. She appeared in some low-budget films in the 1970s and early 1980s. Her work as an actress in mainstream film began in the 1984 fantasy-action film Conan the Destroyer alongside Arnold Schwarzenegger, and the 1985 James Bond movie A View to a Kill. In 1986 she played a vampire in Vamp, and both acted in and contributed a song to the 1992 film Boomerang with Eddie Murphy. In 2001, she appeared in Wolf Girl alongside Tim Curry.
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Headline Booking works to ensure a smooth event and performance for everyone. Although all events are different, some performers require necessary items for a performance. These can include artist's fees, airfare, staging, lighting, hotel accommodations and onsite production staff. Headline booking takes the stress off of you and handles the organization of these necessary elements. As our client, Headline Booking Group works with you to discuss the details of your event. If necessary, we can provide a full service solution for a flat rate.
We can work to find talent for a variety of events, including Corporate Events, Private Parties, Fundraisers and even College Events. Our relationships with Music Artists, Comedians and Celebrity Speakers gives you a choice of hundreds of performers for your event. Our professional, knowledgeable, and courteous staff ensures everything runs smoothly leading up to and on the day of your event. To get started, please fill out the Request Artist Information form.
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Progress Lighting Gulliver Farmhouse Five Light Pendant Farmhouse. From wishlist 0 Ardin Bench.
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text:
Malaysia, Guam secure tough wins to claim FIBA Asia Cup 2021 tickets
Story from: http://www.fiba.basketball/asiacup/2021/pre-qualifiers/news/malaysia-guam-secures-tough-wins-to-claim-fiba-asia-cup-2021-tickets
NONTHABURI (FIBA Asia Cup 2021 Eastern Region Pre-Qualifiers) – Two of the last four tickets to the FIBA Asia Cup 2021 have been claimed, putting pressure on the remaining 4 teams in the final two days. Malaysia and Guam secured big wins against tough opponents to claim their prizes, while Thailand comes in a little closer with their victory.
Guam vs Indonesia (65-53)
Defensive effort kept Indonesia in the game, but Guam fired back with their own lockdown defense to stay undefeated with a 65-53 win.
Earnest Ross was held to a tournament-low 13 points on 5/21 shooting, but Guam as a team were able to hold Indonesia to only 31.7% shooting en route to the victory.
Indonesia applied pressure on Guam for most of the game, starting with an 11-0 run to close out the first quarter in the lead. Jamarr Johnson had a near perfect start going 5-5 to start the game and had 12 points in the first half. Even as Guam tried to break away, Indonesia clawed their way back into the game with a 10-2 run tie the game 42-42, six and a half minutes into the third quarter. It was an impressive defensive stance that saw Guam score only one basket.
Russ Wesley came off the bench to break Guam's shooting slump and his three-point shot ignited a 7-0 run to end the third quarter. Guam continued to flex their defensive muscles, keeping Indonesia without a field goal for 10 minutes to build up a 19-point cushion.
With Guam's shooters struggling, Tai Wesley kept the offense going with 19 points to go with 11 rebounds, and 3 assists.
Indonesia's Johnson had a strong start but struggled towards the end to finish with 15 points, 10 rebounds, and 2 steals.
Guam secures the second ticket to the FIBA Asia Cup 2021 with their undefeated 3-0 record, leaving Indonesia at 1-2 with tough games against Singapore and Thailand in the upcoming days.
Team Guam Basketball 2-0 in FIBA Asia Cup Eastern Regional
Guam completes sweep


text:
Lee Bell ( * Crewe, 26 de enero de 1983) es un exfutbolista y actual entrenador Británico. su último equipo fue  Macclesfield Town de la Football League Two de Inglaterra. Es segundo entrenador en el Crewe Alexandra

Trayectoria
Lee Bell firmó para Crewe como aprendiz en octubre de 2002 y realizó su debut para el club en su empate 1-1 con Northampton Town. Ha sido prestado dos veces para lugares de conferencia, incluyendo Shrewsbury Town y Burton Albion. Tuvo una petición concedida para dejar Crewe y previamente firmó un contrato de corto plazo en Burton Albion. Sin embargo, las cosas no se resolvieron para Lee y ahora es un agente libre después de ser lanzado en abril.

Clubes

Enlaces externos
 Lee Bell en Soccerbase.com

Futbolistas de Inglaterra
Futbolistas del Crewe Alexandra Football Club
Futbolistas del Shrewsbury Town Football Club
Futbolistas del Burton Albion Football Club
Futbolistas del Mansfield Town Football Club
Futbolistas del Macclesfield Town Football Club

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text:
Singing Sopranos
The music of television's best show
July 31, 2018 July 23, 2019 Ken Kurson 3 Comments "Nobody Loves Me But You, A3, Andrea Bocelli, Blue Djinn., David Chase, Defiler, Dori Hartley, Frank Sinatra, Greg Wattenberg, Joe Bosso, Kathy Dayak, Local H., Martin Bruestle, Massive Genius, Nick Fowler, RL Burnside, The Sopranos, Visiting Day, Woke Up This Morning
Every writer has personal favorite stories. (And plenty he wishes could somehow be wiped from the long memory of the internet). This one, which I originally wrote for Green Magazine, is one of my pets. It's not staggering prose or anything. Just that I loved The Sopranos so deeply and felt proud to be able to contribute to the body of knowledge surrounding the show in a meaningful way. We are approaching the 20th Anniversary of the debut of The Sopranos. Back then, unearthing the performer of the key song in the "A Hit Is a Hit" episode in Season 1—and talking to the creators—was kind of a thing. You've got to remember that in the late 90s, not every fact was instantly Googleable. The message boards were all buzzing with people wondering about the massive voice behind the stunning "Nobody loves me but you" chorus as Chrissy smokes on a pool table. (Here's a nice example of many that pointed to my story.) It annoys me that Bankrate sold the Greenmagazine.com URL (to John Deere!). I view it as somewhat Stalinist that a couple years of daily journalism have simply been replaced by stories about tractors. This story has been lost to me for almost 20 years—it originally ran on November 22, 1999—and only returned when I had to get an old hard drive recovered for other reasons. Happy to see that it still holds up, long after all six seasons of The Sopranos have concluded.
Of all the perfect moments on The Sopranos, the one that hits me where I live is the first season's music business episode, A Hit Is a Hit, which first aired on March 14, 1999. Chris has been honest but unkind to Adrianna about her support for a middling band, Visiting Day. She leaves and he's devastated. Later, Chris is sitting on a pool table at the Bada Bing, smoking, thinking. Hesh walks by as a transcendently beautiful and sad song plays on the strip club's stereo. "Now, that's a hit," he says, and Chris knows that there's a difference.
Actually, the song wasn't a hit. In fact, no one seems to know what it is or who sings it. Subject of endless conjecture on HBO's Soprano's message boards (and even the terrific fan-site sopranoland.com can't identify it), the tune is Dori Hartley's "Nobody Loves Me But You," from her album "Blue Djinn." It's a great, great song. And like every single song on the best show there's ever been, it's perfectly chosen.
Blue Djinn by Dori Hartley.
It has to be. Unlike just about every drama, The Sopranos uses no composers, and there is no score. Only licensed music, hand-chosen little gems to capture and enhance what you see before your eyes – from A3's "Woke Up This Morning" for the Lincoln Tunnel intro (which is so apt that people assume it was written for the show) to Springsteen's "State Trooper" to Andrea Bocelli, Frank Sinatra and RL Burnside.
Martin Bruestle is a producer on the show, charged with finding these songs. He is quick to credit series creator David Chase, who he also worked with on Northern Exposure, for the show's music: "Finding these songs is a very collaborative effort. David's tastes are fantastic and he's involved in all the strokes of the brush."
One of those brush strokes was the episode in which Hartley's song appears. Joe Bosso, the writer of that script, was an executive at Island Records, whose signings included seminal hardcore band Quicksand and Local H. Bosso shares with Chase and Hartley a Garden State background. "I was brought up in Jersey — Somerville — and my wife's from Garfield; we're Jersey people. I was an A&R guy over at Island. I was seguewaying into a writing career. I had a script that got some attention and got in the hands of David Chase right when he was plotting the first season of the Sopranos. He wanted to do a shady music business episode of the Sopranos," Bosso recalls. "We needed a band and they had to be astoundingly average. That's harder to do than real bad or real good. I said I know exactly the people. Defiler was born."
Enter Nick Fowler, who played Richie Santini, Defiler's singer. Richie had been Adrianna's boyfriend before being jolted while trying to catch fish with a power line. Bosso remembers, "Fowler had been in New York bands, also had done some acting. I always thought he was extremely talented."
Another member of Bosso's crew was engineer and producer Greg Wattenberg, guitar player and principal songwriter of Defiler. Bosso and Wattenberg often goofed around at Island, writing songs and strumming guitars. The pair started writing songs for Defiler and Visiting Day, the introspective alternaband that Defiler morphs into as Adrianna develops them.
Greg Wattenberg played Vito the guitar player for Defiler and Visiting Day. In real life, he went on to write and produce several No. 1 songs, including 'Easy Tonight' by Five For Fighting, 'It's Not Over' by Daughtry, 'Shattered' by O.A.R. and 'Hey, Soul Sister' by Train.
Wattenberg says Bosso told him to write songs for both bands that were "Thoroughly mediocre, but played with such conviction that people will buy it." Wattenberg recalls that "Chase said he was looking for a bunch of guys who don't know when to give up. I put together mid-30s guys who had been in these cheesy hard rock bands."
When the proto band had enough material, Bosso says, "David Chase came to a rehearsal to see if Nick had the right look. He gave the band his blessing," and even ended up casting Wattenberg to appear in the episode, as Defiler/Visiting Day's guitarist.
Wattenberg laughs as he recounts his screen debut: "They called me Vito. I'm this Jewish guy and they gave me this big Italian name. My big line is 'It'll probably be our first single.' I was standing at the back trying to look tough and my brothers are like, 'You can't even act like you're standing around.'"
Wattenberg's big line reflects lots of familiarity with the kinda sad but kinda sweet world of the musician whose day is past. The reason the show is perfect is that it finds these moments of unexpected tenderness, hidden in the worlds of low-level mobsters and over-the-hill musicians. Wattenberg knows that moment first-hand. "Every band I produce always has their biggest song, the obvious single. And they don't want to make it their first single – they wanna go with some much-less-appealing song; going with the obvious choice is a sell-out."
Another reason the show is special is that even the not-quite-there band they put together cooks up some extremely memorable moments. When Chris and Adrianna bring rap impressario Massive Genius to see Visiting Day, their song "Erase Myself" meanders at midtempo, ridiculous but pretty good, too. Or the Defiler tune that plays over the closing credits, the sort of band theme song that a group like Bad Company might employ: "Stay Out of our way, don't be so gay / We're coming to defile, defile you." Bosso says, "We were trying to think of what these idiots from New Jersey would sing."
According to producer Bruestle, songs for the show are often chosen as scenes are viewed in the studio. "For 'Wheel in the Sky,'" referring to the Journey hit that plays in season two as Carmela contemplates her marriage and new interest in a wallpapering he-man, "David was in LA, I was in NY to do some looping. Kathy Dayak [Sopranos music editor] and I were sitting together, playing music, laughing at songs, getting a kick out of them. I walked out of the office and dropped off Journey's Greatest Hits CD and that song just fit perfectly."
Bruestle confirms how important the songs are, noting that choosing one instead of the other can have dramatic impact. "For every song you end up using, there are 20 that do something else to the scene. You don't create these choices at the script level. You play the music against the images after you've shot it. There's so many things you can do with music. Restraint in its selection is what we're trying to do with it. To not be in your face totally."
For Dori Hartley, her song's appearance might not have been in anyone's face, but meant plenty. "It was thrilling to see 'Nobody Loves Me But You' featured so nicely in the Sopranos."
Thrilling is right.
Ken Kurson
Ken Kurson is the founder of the Globe suite of sites. He is also the founder of Green Magazine and greenmagazine.com and covered finance for Esquire magazine for almost 20 years. Ken is the author of several books, including the New York Times No. 1 bestseller Leadership.
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Tags: "Nobody Loves Me But You, A3, Andrea Bocelli, Blue Djinn., David Chase, Defiler, Dori Hartley, Frank Sinatra, Greg Wattenberg, Joe Bosso, Kathy Dayak, Local H., Martin Bruestle, Massive Genius, Nick Fowler, RL Burnside, The Sopranos, Visiting Day, Woke Up This Morning
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I posted the pattern under Pattern Links. It is a video and I am typing it in Word as I go. Of course I am stuck on the end of the second row (image below).
This stitch is quite a bit different than any I have done. I think I should wind up having 28 stitches on my hook. I have 26 so far and am not sure where to insert my hook for the next two?


Philip Charles Woolridge is a Los Angeles based documentary photographer. With strong influences from film, Woolridge has a cinematic approach to documenting everyday life. Drawing inspiration from war photographer Robert Capa, civil rights photographer Gordon Parks, and painter Edward Hopper. While attending the Seattle Film Institute 2014-15, Woolridge's studies were focused on cinematography. Woolridge now lives in Los Angeles and works as a Set Lighting Technician for film. Between productions, he spends his time documenting life throughout Los Angeles.


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text:
Dylan Larkin, Detroit Red Wings look to right ship vs. Maple Leafs
By Chris Lavallee
Tonight, the Detroit Red Wings will travel to Toronto to take on the Toronto Maple Leafs in an original six matchup. The Red Wings are looking to get back in the win column after dropping two in a row as they continue to fall in the division and conference standings.
Tonight's Red Wings player to watch: Dylan Larkin
Larkin has been the best player on the Wings this season. He has been on the top line and been productive no matter who's been his wingers. Tonight, he is set to play alongside Michael Rasmussen and David Perron on that first line for Detroit. In Larkin's career, he has appeared in 540 games for the Red Wings, and he has scored 160 goals and tallied 231 assists, good for 391 points. So far this season, Larkin has scored a team-high 13 goals and he has 20 assists for a total of 33 points, which is good enough for the most points on the team.
Larkin will be on the first unit of the power play playing with Lucas Raymond, Filip Hronek, Rasmussen, and Perron. Larkin has scored five power-play goals and six assists for 11 points. Larkin has also scored a shorthanded goal this year as well. Against the Maple Leafs this season Larkin got one point in the lone matchup, with an assist on a Moritz Seider goal. In his career against the Leafs, Larkin has eight goals and 10 assists for 18 points in 22 games played. Look for The Captain to find the scoresheet against the Red Wings' original six rival.
RECAP: Detroit Red Wings Frustrated by 5-2 Loss to Edmonton Oilers
Despite strong play, Detroit Red Wings fall to Edmonton Oilers 5-2. Why it Matters The Red...
The Red Wings take on Oilers in the second half kick off, facing challenges of Larkin contract & the potent McDavid offense.
Moritz Seider, the Red Wings' first-line power-play defender, will face one of the league's top goal scorers, Connor McDavid. See how Seider's physical play could impact the game and help the Red Wings secure a win.
Michael Rasmussen
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Graphically the dependence of a value from another. Using charts the relationship between the data becomes more clear. PowerPoint Training Courses facilitate comparison of different data. Created PowerPoint presentation will be played on almost any computer. In the .zip file contains 20 editable slides.


Skout's Honor today announced the addition of two new products to its line of better, faster and stronger solutions to everyday pet messes and odors – a Patio Cleaner & Deodorizer and a Cat Urine & Odor Destroyer. The new products will make their official debut this week at the American Pet Products Association (APPA) Global Pet Expo (Orlando, Florida, March 16-18, 2016), in the Skout's Honor Booth #2487.
A powerful cleaner and deodorizer optimized for use on unsealed concrete, outdoor stone and artificial turf.
Skout's Honor products leverage BioKore™ technology and/or a rapidly biodegradable molecular deodorizer to provide pet owners with better, faster, and stronger environmentally and socially conscious cleaning solutions.
The Skout's Honor family of products is available at retailers across the United States and Canada, and also on Amazon.com. For specific retail locations, please visit the store locator.
Visit Skout's Honor in Booth #2487 at Global Pet Expo and find out what all the buzz is about. For distribution and sales opportunities, please contact Shannan Morlas, National Sales Manager, at shannan(at)skoutshonor.com.


Looking for a fun bag for the winter? Check out this DIY felt clutch featuring a fun girly quote.
I don't know what it is about this time of year, but I am driven to organize every last thing in my house. I've been working through my holiday decor the last few weeks, but I took a break to focus on a smaller project for a couple of hours.
I updated a felt clutch I found in the dollar bins at Target with some gold foil and I am using it to hold all the little cards and lip glosses! If you can't find the same clutch, don't worry you can snag a plain canvas one online pretty easily.
Download the cut file in the format that works best for you (see supply list above).
Upload the design to your design software and create the appropriately sized layout. I sized my designs about eight inches wide.
Mirror the image so that the text appears backwards on the screen. Feed the heat transfer material into your machine with the glossy side down. Select HTV in the media menu and cut.
Peel the negative space in the design off the plastic backing, leaving only the words and shapes on the clear plastic transfer sheet.
Pre-heat the clutch you're planning to transfer the design on for about five seconds and crease the center for reference.
Position the design on the clutch face down so that you see it through the clear transfer sheet. Your text should be facing the right direction at this point.
Place a thin cloth or parchment paper over the design and place a heat on top PRESSING FIRMLY into the design for 45-60 seconds OR if you have this amazing little portable heat press 15-20 seconds!
Remove the iron and cloth. Gently peel up the transfer sheet. If the HTV continues to stick to the transfer sheet, replace the cloth and iron again making sure to apply pressure.
Note: Follow the instructions on your HTV to determine if the transfer sheet should be pulled back when the vinyl is still hot or if you should wait until it's cooled. When using foil, I wait until it's cool.


Why is it So Fascinating to Train Travel in Europe?
London to Paris train, are you interested?
Europe is a smorgasbord of art, history, and culture. There is no surprise then that it is also home to the best sunsets. At SaveaTrain, the train ride is all about the journey, not always the destination. So, sit back and relax and be prepared….


Preserving evidence, interviewing potential witnesses, documenting relevant locations, negotiating cooperation, and coordinating turn-ins are all services that an attorney can provide even before charges are formally filed. A lawyer can minimize or eliminate much of the uncertainty and apprehension associated with knowing that a person is being investigated for a criminal offense. Once law enforcement is notified that a lawyer represents an individual, they may not attempt to communicate with the individual and must instead, go through the attorney. The attorney serves as a buffer between law enforcement and the suspect.
A proactive approach is the best approach. Many investigations take days, weeks and even months to complete before charges are actually filed. During the pending investigation a person suspected of a criminal offense should be proactive in maximizing the opportunity to mount an effective defense in the event charges do get filed. This requires obtaining witness statements, documenting relevant locations and weather convictions and ensuring any video or audio recordings are properly preserved. A lawyer knowledgeable in representing a defendant before charges are filed can immediately put together a pre-charge investigation that is imperative to preserve potentially crucial evidence that may have been missed or even ignored by law enforcement.
Another function a qualified lawyer can serve before charges are filed is to act as a go-between between the suspect and law enforcement and/or the prosecution. Cooperation with the authorities is always an option and is commonly presented by law enforcement during narcotics investigations. Some are willing to cooperate, others are not. If a person elects to cooperate with law enforcement, having an enforceable cooperation agreement is imperative to ensure that any cooperation provided is honored by law enforcement. Absent a formal agreement, law enforcement is free to use the person for cooperation purposes and then still turn around and file the charges against them after they are no longer useful.
In the event that an individual elects not to cooperate, often time an arrest warrant is issued once charges are filed. When this happens, the person charged can be arrested anywhere, at any time. Many are fearful that they will be arrested at work, in front of employees, or worst yet, at home, in front of their children. Often times an attorney can contact law enforcement, be notified when the warrant is finally issued, and coordinate with the defendants surrender to authorities. This minimizes the embarrassment associated with being publicly arrested and equally important, allows the person being charged to coordinate and secure bail before being turned in, thereby minimizing their time in jail before being released.


Ever since his baby brother Will was born eight months ago, Jonah's life seems to be getting worse and worse. His sixteen-year-old brother Jesse has severe food allergies that make it hard to even live in his own home, and he's having more reactions lately. Will won't stop crying, and Dad and Mom seem pretty clueless. Jonah knows that when a bone breaks, it grows back stronger…so he sets out on a mission, breaking his bones to become stronger through skateboard "accidents". But will his only release break him?
Hannah Moskowitz's debut novel is startling, blunt, and complete absorbing. Jonah is a wholly believable character, and the first person narrative makes it easy to immerse yourself into the story, but will also have you cringing constantly as Jonah plans out which bones he will break next, keeping a tally, and carries out his schemes. Moskowitz is skilled at balancing a myriad of issues that threaten to overwhelm Jonah: his worries and fears for his brothers, friend issues, guilt, and the need to protect everyone, making them believable and engrossing.
The pacing of the novel is excellent; Jonah's dry sense of humor help keep the plot from being too morbid, and Moskowitz's dialogue is pitch-perfect. Though Jonah does allude to certain issues that happened in the past and might have been interesting to learn more about, and the wrapping up of the novel is slightly confusing, the style and pace do stay consistent, making for a riveting and suspenseful read, and the ending isn't cookie-cutter perfect and unbelievable. Break is both gruesome and stunning, one of those books you cringe to read but can't put down.
Cover Comments: This is an excellent cover; it's simple, but quite effective. I like how it isn't completely black and white and red, but has the gray in it, and and the broken bone on the cover has the appropriate effect.
My immediate thoughts: creepy/bizarre/awesome. I think I'll like this book. Great review!
Add this one to my TBR-- anything with skateboarding in it is so rare, and problem novels are popular with my 8th grade boys. Thanks!


text:
Q: Generate misspelled words (typos) I have implemented a fuzzy matching algorithm and I would like to evaluate its recall using some sample queries with test data.
Let's say I have a document containing the text:
{"text": "The quick brown fox jumps over the lazy dog"}

I want to see if I can retrieve it by testing queries such as "sox" or "hazy drog" instead of "fox" and "lazy dog".
In other words, I want to add noise to strings to generate  misspelled words (typos).
What would be a way of automatically generating words with typos for evaluating fuzzy search?

A: I would just create a program to randomly alter letters in your words. I guess you can elaborate for specific requirements of your case, but the general idea would go like this.
Say you have a phrase
phrase = "The quick brown fox jumps over the lazy dog"

Then define a probability for a word to change (say 10%)
p = 0.1

Then loop over the words of your phrase and sample from a uniform distribution for each one of them. If the random variable is lower than your threshold, then randomly change one letter from the word
import string
import random

new_phrase = []
words = phrase.split(' ')
for word in words:
    outcome = random.random()
    if outcome <= p:
        ix = random.choice(range(len(word)))
        new_word = ''.join([word[w] if w != ix else random.choice(string.ascii_letters) for w in range(len(word))])
        new_phrase.append(new_word)
    else:
        new_phrase.append(word)

new_phrase = ' '.join([w for w in new_phrase])

In my case I got the following interesting phrase result
print(new_phrase)
'The quick brown fWx jumps ovey the lazy dog'

A: Haven't used this myself, but a quick google search found https://www.dcs.bbk.ac.uk/~ROGER/corpora.html which I guess you can use to get frequent misspellings for words in your text. You can also generate misspellings yourself using keyboard distance, as explained here, I guess: Edit distance such as Levenshtein taking into account proximity on keyboard
Perhaps there are some other databases/corpora of frequent misspellings other than the one referred to above, because I would guess that just randomly inserting/deleting/changing characters with a total levenhstein distance of, say, max 3 will not be a useful evaluation of your system, since people don't randomly make mistakes, but exhibit simple, logical patterns in the types of (spelling) mistakes made.


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Appears vertically and is identified by letters at the top of the worksheet window.
An equation that calculates a new value from values currently in a worksheet.
Appears to the right of the Name Box and displays a formula when the cell of a worksheet contains a calculated value.
A page turned so that its longer side is at top.
The spreadsheet program in Microsoft Office 2010.
Cell reference area located below the Ribbon, displays the cell reference of the active cell.
A page turned so that its shorter side is at top.
A group of selected cells.
How the range is identified; made up of the cell in its upper-left corner and the cell in its lower-left corner, separated by a colon.
Appears horizontally and is identified by numbers on the left-side of the worksheet window.
Tab at the bottom of the worksheet window that displays the name of the worksheet.
A grid of rows of rows and columns in which you enter text, numbers, and the results of calculations.
You can align the contents of a cell horizontally and vertically within the cell.
Determines the best width for a column or the best height for a row, based on its contents.
A line around a cell's edges.
A collection of formatting characteristics you apply to a cell or range of data.
Determines the height of characters as measured in points.
Using effects such as bold, italic, and underlining to add emphasis to a font.
Enables you to copy formatting from one worksheet cell to another without copying the cell's contents.
Change the way the data looks in a cell.
Changing the angle at which the data is displayed.
A unit of measurement for font height.
Combination of formatting characteristics such as alignment, font color, and borders.
Preset collection of design elements.
When the row height adjusts automatically to include additional lines until all the text is visible.
Excel inserts this whenever it runs out of room on a page.
Duplicates the cell's contents without affecting the original cell.
Appears in the lower-right corner of the active cell or range, and is used to fill cells.
Copies a cells contents and/or formatting into an adjacent cell or range.
Text that prints in the bottom margin of each page.
You select rows and/or columns to remain visible on the screen as the rest of the worksheet scrolls.
Text that prints in the top margin of each page.
Insert this manually to start a new page.
Blank spaces around the top, bottom, and sides of a page.
View used when entering and formatting data in a worksheet.
A temporary storage area for up to 24 selections you copy or cut.
Shows you the location of page breaks and allows you to change them easily.
Places the last item from the clipboard into the cell or range selected in the worksheet.
Consists of the cells and ranges designated for printing.
Designated rows and/or columns in a worksheet that print on each page.
Enables you to resize a worksheet to print on a specific number of pages.
Divides the worksheet window into tow or four pages that you can scroll independently.
The value the function uses to perform a calculation, including a number, text, or a cell reference that acts as an operand.
Functions that are used to insert dates and times in a worksheet.
Functions used to analyze loans and investments.
As you begin to type a function name, this feature shows a list of functions below the active cell.
Shorthand way to write an equation that performs a calculation.
Functions that display text or values if certain conditions exist.
Functions, such as the square root and rounding functions that manipulate quantitative data in a worksheet.
Functions used to describe large quantities of data.
Functions that are used to format and work with cell contents.
Functions, such as the natural logarithm, that manipulate quantitative data in a worksheet.
Does not change when copied or moved to a new cell.
Lets you determine when Excel calculates the formulas.
Cell references that contain both relative and absolute references.
A constant (text or number) or cell reference used in a formula.
A symbol that indicates the type of calculation to perform on operands.
The sequence used to calculate the value of a formula.
Allows you to point and click each cell in a formula rather than typing cell references.
Adjusts to its new location when copied or moved.
Makes adding long columns or rows of numbers simple to do.


text:
UB Researchers Use Computer Cluster to Create Model of Contaminant Flow in Groundwater
BUFFALO, N.Y. -- When engineers conduct research on groundwater, the water that flows beneath Earth's surface, they usually think of "large-scale" as one watershed -- an area of land where all of the water on it or under it drains into the same place, such as a lake and its tributaries.
Using a 300-node Dell high-performance computing cluster (HPCC) in the Center for Computational Research (CCR) at the University at Buffalo, Alan Rabideau, Ph.D., and Igor Jankovic, Ph.D., are working to turn that definition on its head.
The goal of the researchers is to create what could be the first groundwater model capable of accurately representing how contaminants flow through groundwater in multiple watersheds at a variety of scales, ranging from the size of individual grains of soil to bodies of water that cover many miles.
"Ultimately, we're interested in problems like climate change and its impact on the Great Lakes," says Rabideau, an associate professor in the Department of Civil, Structural and Environmental Engineering in the UB School of Engineering and Applied Sciences.
In addition to Jankovic, UB assistant professor of civil, structural and environmental engineering, the other members of the team are Douglas Flewelling, Ph.D., UB assistant professor of geography, and Matt Becker, Ph.D., UB assistant professor of geology.
The team is focusing on developing more efficient algorithms so that the resulting models accurately represent groundwater flow at many scales. The project requires the power of a computer cluster that has many, independent processors.
The groundwater research group "graduated" to the 300-node Dell cluster it now uses from a Dell mini-cluster that it used grant money to purchase last year.
"The Dell mini-cluster was unbelievably bulletproof," says Jankovic. "You could not crash that machine."
It's not for lack of trying. Last year, Jankovic's simulations of the behavior of contaminants through groundwater chewed through 280,000 central processing unit hours, the equivalent of 32 years of computing time on a personal computer.
"I use the computer to describe the microscopic movement of contaminants," explains Jankovic, "which then helps us to identify the parameters for the equations in the model. In other words, I simulate the system on a microscopic scale in order to get parameters for simulations on a regional scale," he says.
At the same time, Rabideau studies the chemical end of things, examining and accounting for how differences in individual soil particles influence contaminant transport in groundwater.
"Groundwater systems are fascinating because of the relatively large variations in soil properties that occur over relatively small distances," says Rabideau. "These differences must be accounted for in computer models used to assess the movement and cleanup of pollutants."
In addition to effectively describing processes that occur over multiple scales, the research will require integrating the models with field data and geographic information systems, tasks that Becker and Flewelling are carrying out.
"These challenges cannot be met without the power of multiple, high-speed processors," explains Jankovic.
Existing models of groundwater flow, he adds, were developed decades ago, mostly by the U.S. Geological Survey.
"They have updated these models and added new features, but they were never designed for modern computer architectures," says Rabideau.
Consequently, 21st-century challenges, like studying the complexities of climate change, cannot be tackled adequately using the models.
"If precipitation levels change, for example, as a result of climate change, how is that going to affect levels on the Great Lakes and how will that, in turn, affect groundwater supplies around the lakes?" asks Rabideau.
The exchange between groundwater and the Great Lakes is not well-understood, he added, but it is becoming increasingly important as cities, like Chicago, that border the lakes, increase their reliance on groundwater.
"Traditionally, groundwater models are developed for a particular area in a watershed," explains Rabideau. "The engineers divide the area into a grid, and apply computational tools to do the simulations that are proportional to the size of the area.
"Our approach is fundamentally different. We are developing models not based on the size of a given area, but rather on hydrologic or chemical features that drive the groundwater, such as the number of lakes or changes in soil type."
Such detailed simulations will provide a much more comprehensive view of groundwater, data that will be necessary as demands on groundwater grow and to ensure monitoring of the safety of groundwater supplies that face increasing threats from non-point source pollutants or even terrorist attacks, explained Rabideau.
"We know that contaminants of any kind are incredibly difficult to get out of a groundwater source," he says.
The UB researchers plan to demonstrate their new simulations of groundwater flow on the small scale using Ischua Creek, just south of Buffalo; at the mid-sized scale, using the Trout Lake area in northern Wisconsin, home to hundreds of lakes, and ultimately, the entire Great Lakes watershed, at the large-scale.
The research was initiated by a $1 million Environmental Protection Agency grant awarded to Rabideau in 2000 to do groundwater simulations using supercomputers. Since then, members of the team have been awarded additional grants totaling more than $500,000 by the National Science Foundation.


text:
Home / Environment
WHITE PLAINS, NY, Oct. 25, 2011 (PR Web) -Guaranteed Home Mortgage Company, Inc., a national residential mortgage investment and banking firm, today announced a new green initiative to cut paper usage through an increased emphasis on electronic operations.
The initiative includes the use of an industry mortgage program with electronic application forms, increased reliance on electronic advertising media and a new focus on inbound marketing through a vigorous online presence.
David Wind, President of Guaranteed Home Mortgage Company, said, "We are trying to transform a paper-intensive industry into an efficient cyber organization. In addition to providing improved customer service and reduced response times through online mortgage applications, we are focusing on inbound marketing, an approach more typical for online promotion, and an increasingly important component of the marketing mix. Direct mail wastes environmental resources and has become much less effective for our purposes."
Wind went on to promote the company's new website at http://www.ghmc.com and to tout its customer-centric focus. Search engine optimization in tandem with electronic advertising is playing an important role in generating traffic.
Founded in 1992, Guaranteed has continued to grow rapidly since its inception, bucking the current trend in the industry at large. It was listed in the Inc. 500 list of fastest growing companies in the nation and maintains a weekly blog at http://www.joinguaranteed.com/blog with advice both for homebuyers and mortgage professionals.
For more information, please contact Kelley Berkheiser at 914-696-3400, or write Guaranteed Home Mortgage Company, Inc., 108 Corporate Park Drive, Suite 301, White Plains, NY 10604.
About Guaranteed Home Mortgage Company
Founded in 1992, Guaranteed Home Mortgage Company (Guaranteed), a licensed mortgage investment and banking firm, is comprised of more than 300 mortgage professionals lending in 28 states. The company, previously named in the Inc. 500 list of the fastest growing companies in the United States, provides residential mortgage financing to a wide variety of consumers and real estate professionals.
David Wind, an attorney, is Principal and President of Guaranteed. Previously, he served as a financial analyst of mortgage-backed securities at Citicorp Investment Bank and clerked in the real estate finance department of the New York State Attorney General's Office.
Guaranteed Home Mortgage Co cuts paper use in new green initiative
ABERCROMBIE POINT, NS, Oct. 24, 2011 (Local News) -A project that will cut Northern Pulp's odour emissions by 70 per cent is underway
The mill has been shut down for regular scheduled maintenance, as well as installation of improved environmental projects, since Oct. 16.
Don Breen, vice-president of Business Development and Environmental Affairs, says this shutdown is the busiest in recent memory for the mill, contractors and local businesses. Over 600 contractors, 145 term employees and over 200 Northern Pulp employees have been onsite each day to carry out the projects.
New Glasgow News - Pulp mill shuts down for environmental upgrades
RISI is not responsible for the reliability or availability of content on external websites.
Northern Pulp curtails Nova Scotia mill for boiler upgrade, odor project
MANILA, Oct. 19, 2011 (Press Release) -Paper from KHAN-NA, a unique sustainable tree farming program of Thailand-based premium quality paper maker Double A ( www.DoubleAPaper.com ), emerged as the winner in the Poverty Alleviation category of the 9th Asian Corporate Social Responsibility (CSR) Awards, Asia's premiere awards program in corporate social responsibility.
"We are deeply honoured and grateful for being considered as one of the best in Asia in alleviating poverty. This award is a validation that our Paper from KHAN-NA program is a representation of Asian ingenuity and our strong commitment in corporate social responsibility," said Mr. Thirawit Leetavorn, Double A senior executive vice president.
Alleviating the lives of Thai farmers from poverty
Double A Paper launched Paper from KHAN-NA program with the goal to modernise the pulp and paper industry through a revolutionary Asian solution to sourcing fiber. Paper from KHAN-NA is the production of sustainable fiber through the cultivation of Double A Paper-Tree, a hybrid species of hardwood which is well adopted to Thailand's tropical climate, in straight rows along Khan-Na, the unused space between rice paddies.
This program seeks to address two social issues faced by Thai farmers such as the difficulty of finding agricultural employment during off peak season and the instability of income from planting cash crops which is directly affected by several factors such price fluctuation.
Under this program, Double A offers farmers with a buyback guarantee which they earn after 3-5 years of paper tree cultivation. Matured trees are sold back to Double A which will be used as a sustainable raw material for high quality paper production. In this process, Thai farmers enjoy the aggregate additional income of up to THB 5 billion.
Double A Paper from KHAN-NA also provide occupational opportunities for the community. Aside from the buyback guarantee farmers also earn supplementary income from cutting matured trees, transporting logs to Double A mill and working in nurseries where tree saplings are initially grown. The additional income that farmers earn enables them to send their children to school.
Double A Paper from KHAN-NA is already a nationwide program which covers 60 provinces of Thailand. The program aims to encourage additional 10,000 farmers every month and 1 million farmers after 5 years.
Environmentally responsible production of fiber
While increasing the farm income, Double A Paper from KHAN-NA also increases carbon capture and helps in preserving the world's natural rainforests from deforestation. 400 million Double A Paper-Tree grown along KHAN-NA absorbs 6.7 million tons of CO2 per year. Paper from KHAN-NA produces sustainable fiber without the need to source from natural forest trees to support its fiber requirements. This is Double A's unique approach to raising sustainability among the local communities and while preserving the environment for generations to come.
Asia's premiere CSR awards program
The yearly event organized by the Asian Institute of Management (AIM) recognizes and honors Asian companies and non-Asian companies with strong presence in the Asian region alike for their excellent CSR works and commitments. The awards come in four categories namely Health Enhancement, Environmental Excellence, Poverty Alleviation and Educational Improvement.
His Excellency, Benigno S. Aquino III, the President of the Philippines, handed over the awards to the winning companies. The awards were presented by the Ramon V. del Rosario, Sr. Center for Corporate Social Responsibility, the Asian Institute of Management and Intel.
Asian CSR Awards concludes the 2-day Asian Forum on Corporate Social Responsibility (AFCSR) held at the Edsa Shangri-la Hotel which brought together in one venue the very best CSR practitioners in Asia and other parts of the world to share the how to's of CSR. The conference is said to be the best program in the region assembled on CSR.
About Double A
Double A paper is manufactured by Double A (1991) Public Company Limited, one of the most advanced fully-integrated pulp and paper manufacturers in the world. Double A paper is produced from fast growing farmed trees grown by contract farmers in Thailand, providing local farming families extra income. The farmed trees absorb 6.7 million tonnes of carbon dioxide from the atmosphere and release 4.9 million tonnes of oxygen into the atmosphere every year. Double A's pulp and paper production practices set an industry benchmark in environmental responsibility. Double A uses water from a purpose-built 36 million cubic metre reservoir that collects rainwater and run off, and is used to provide the mill with 100% of its water needs, while recycled water is used to irrigate the trees. Additionally, Double A uses tree waste (bark and lignin) to provide electricity for the mill, saving 340 million litres of oil being used annually. This also generates more electricity than the mill can use and the excess is sent back to the local grid. Double A produces a smoother, brighter, whiter, high-quality copy paper that helps businesses to run smoother with minimal impact to the environment. Double A paper and stationery products are available in more than 120 countries worldwide. For more information, please visit www.DoubleAPaper.com .
Double A program wins Asian corporate social responsibility award for poverty alleviation
TORONTO, Oct. 11, 2011 (CNW) -Today, Margaret Atwood and forest advocacy non-profit Canopy released a limited special edition of Atwood's new book In Other Worlds: SF and the Human Imagination, on a revolutionary new form of paper. Developed by Canopy, Second Harvest Paper is a North American first, containing only straw leftover after the grain harvest and recycled paper. The special edition Atwood title is the first book in North America to be printed on this pioneering paper.
"I joined Canopy in this trial to show that we can meet our paper needs using low-footprint straw instead of relying on endangered forests," says Margaret Atwood. "Second Harvest Paper is the kind of practical innovation that could make paper from endangered forests ancient history."
Canopy arranged the rare Atwood special edition to demonstrate the viability of Second Harvest Paper as an alternative to conventional papers. Second Harvest Paper is part of a broader Canopy campaign to diversify the North American paper fibre basket in order to reduce the stress on endangered forests by kick starting commercial scale development of straw based papers.
"There is enough leftover straw in North America to keep up to 800 million trees standing every year and Canopy has already identified customer demand to keep four pulp mills running full time," says Nicole Rycroft, Executive Director of Canopy. "Shifting paper production from our endangered forests to our fields would yield a new resource sector with benefits to farming communities, our economy, and forest ecosystems around the world."
The special edition books are published by McClelland & Stewart. The Canadian publishing giant already prints many of its titles - including the main run of Atwood's In Other Worlds - on 100% post-consumer recycled paper as part of an environmental initiative developed with Canopy ten years ago.
"We're very pleased with the way the special edition looks on the Second Harvest Paper," says Doug Pepper, President and Publisher of McClelland & Stewart. "For many years M&S has worked with Canopy to find new alternatives to conventional paper and we look forward to shifting more of our titles to Second Harvest as soon as it's more commercially available."
The Second Harvest Paper used in the Atwood book has half the ecological footprint of conventional paper and is the product of a unique partnership Canopy forged with paper producer Cascades Fine Paper, technical collaborators at Alberta Innovates, and leading North American printer Friesens.
"This trial has shifted Second Harvest Paper from theoretical possibility to tangible product, and made it an important business strategy for Cascades," says Julie Loyer, Communication & Sustainable Development, Cascades Specialty Products Group. "In order to make Second Harvest Paper available commercially what we need now is government and other industry players to join us in making a reliable North American supply of straw pulp."
Signed special edition copies of In Other Worlds on Second Harvest Paper are available exclusively through Canopy (www.canopyplanet.org). Main run copies of the book are available in bookstores across North America.
Canopy is an environmental nonprofit organization dedicated to protecting the world's forests, species and climate. Canopy works collaboratively with 700+ of the forest industry's biggest North American consumers to protect forests by influencing purchasing habits and developing support for large-scale conservation initiatives such as the Boreal Forest Agreement and Great Bear Rainforest Agreement. Canopy drives the development of tangible solutions, like Second Harvest Paper, that meet business needs without harming the world's endangered forests.
Canadian publisher launches book edition on straw-based recycled-content paper in effort with Cascades
KINGSPORT, TN, Oct. 10, 2011 (Business Wire) -Eastman Chemical Company today released its second sustainability report, a comprehensive review of the company's sustainability strategy, progress, advancements and goals.
"Sustainability is an essential part of Eastman's business, representing our culture of continuous improvement, innovation and responsibility," said Jim Rogers, chairman and chief executive officer, Eastman. "Eastman's growth will depend on how well we continue to integrate sustainability into everything we do -- from running energy efficient operations and developing sustainable products, to protecting the earth's valuable natural resources and actively engaging with the communities in which we live and work. We believe sustainability is beneficial to our business, our customers and, most importantly, our world."
A significant milestone over the past year was Eastman's appointment of a Chief Sustainability Officer (CSO), Godefroy Motte, who brings additional pioneering thinking and a personal passion to further the company's deep-rooted commitment to sustainability.
The sustainability report provides empirical data through 2010 and includes Eastman's progress through 2011, including advances made in its sustainably advantaged products and processes and measurable short-term, mid-term and long-term goals. Highlights include:
Integrating its annual Responsible Care®performance into the foundation of its sustainability activities
Ensuring that two-thirds of revenues from new product launches are advantaged on assessed sustainability criteria by 2015
Using cogeneration, Eastman converts approximately 70 percent of the energy it obtains from fossil fuel into power and steam to run its manufacturing processes.
Pledging to reduce energy intensity by 25 percent over a 10-year period in partnership with the United States Department of Energy'sSave Energy NowLeader program
Planning to have preliminary Life Cycle Assessments (LCAs) for all new product family launches by 2015 and have already completed LCAs on more than half of the product families that represent 80 percent of its current revenues
Implementing a Strategic Safety Initiative and setting new aggressive goals
"I am pleased about the progress we have already made, and am committed to leveraging sustainable development as a source of competitive advantage." said Godefroy Motte, Chief Sustainability Officer, Eastman. "With this report, we are increasing our commitment and our transparency across the three dimensions of sustainability. The next step on Eastman's journey will be the publication of our first Global Reporting Initiative (GRI) supplement to further detail our performance in accordance with the international sustainability reporting standard."
About Eastman Chemical Company
Eastman's chemicals, fibers and plastics are used as key ingredients in products that people use every day. Approximately 10,000 Eastman employees around the world blend technical expertise and innovation to deliver practical solutions. The company is committed to finding sustainable business opportunities within the diverse markets and geographies it serves. A global company headquartered in Kingsport, Tenn., USA, Eastman had 2010 sales of $6 billion.
Eastman Chemical releases second sustainability report to provide empirical data through 2010
Posted in: Chemicals 10/10/2011 - 06:17
KAMLOOPS, BC, Oct. 4, 2011 (Local News) -Both the corporation and the regulator say Domtar's new pollution system is working as designed and is thus far lowering particulate in the airshed.
Domtar's Kamloops pulp mill began commissioning the new system in mid-September, starting with a single power boiler and one stack. Eventually the second power boiler will come on line, with particulate emitting from the second stack.
An Ontario spokeswoman for Domtar, Bonny Skene, said in an email message the equipment "appears to be working well, with indications being that that emissions will be well within our new, lower permit limit for fine particulate...."
Kamloops Daily News - Domtar, regulator agree pulp mill lowering particulates in air
Domtar pollution system working as designed to lower particulate emissions at Kamloops, BC, pulp mill
LAUNCESTON, Tasmania , Sept. 28, 2011 (Press Release) -Gunns Limited Managing Director Greg L'Estrange today welcomed the view of Tasmania's Environmental Protection Agency Director in relation to substantial commencement for the Bell Bay pulp mill project.
Under the Pulp Mill Assessment Act 2007 Gunns had a requirement to demonstrate substantial commencement of the project by 30 August 2011 and provided the EPA with a detailed submission earlier this month outlining the nature and scope of activity on the project to date.
The EPA Director Alex Schaap today outlined his view that the project has "substantially commenced" and that the permits remain valid.
Mr L'Estrange said, "We are pleased that the EPA accepted the case we put to it, and has laid to rest any concerns that the permit was not valid."
"More than $239 million has been spent by Gunns across four major work streams - regulatory approvals, the commercial and financial framework, social-political interactions, and physical site works - in what is a complex and major infrastructure project for the nation," he said.
"Over $195 million has been spent since the Pulp Mill Permit was issued on 30 August 2007."
"This outcome adds welcome clarity to the whole project, but also to the ongoing discussions we're having with potential project investors."
Mr L'Estrange said negotiations were continuing with two possible equity partners for the mill project, but that there was no immediate timeframe for an outcome of those discussions.
For a full copy of the EPA Directors view regarding substantial commencement please seehttp://www.epa.tas.gov.au/.
Given the level of interest in the project, Gunns has also advised the EPA that its submission in relation to substantial commencement be made available to the public, and this has also been placed on the EPA and Gunns websites.
Gunns welcomes Tasmania EPA affirmation of Bell Bay pulp mill project permits
HOBART, Tasmania, Sept. 28, 2011 (Press Release) -Director EPA Alex Schaap has today concluded his consideration of whether substantial commencement of the pulp mill project had occurred on 30 August as required by the Pulp Mill Assessment Act.
In August, Mr Schaap received a proposal from Gunns to make a minor variation to the storm water management plan for the Bell Bay pulp mill site.
As a result, Mr Schaap requested Gunns provide him with a submission setting out the reasons why the company believes substantial commencement has occurred.
"I have considered the evidence presented to me by the company and have obtained additional documentary substantiation of that evidence. I have also taken advice from the office of the Solicitor General," Mr Schaap said.
"I have reached the view that substantial commencement has occurred.
"I do not therefore feel obliged to seek an order or declaration from a court on the question. I will continue to regulate the site on the basis that a valid permit exists unless a court determines otherwise."
The view of the Director EPA is availablehere
Tasmania environmental agency gives clearance to Gunns pulp mill project
How to save 750 million liters of water a year
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Fibria selects Veolia to supply all three water units for pulp mill expansion in Brazil
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Italy's hardline approach reflects breakdown in regional cooperation on migration – HRW
"The divisive political debate in Europe should not obscure the fact that a principled approach could both uphold human rights and manage migration".
by Caroline Muscat June 18, 2018, 8:49 am
Photo: Ggia / WikiCommons
The recent refusal of the Italian government to allow a nongovernmental rescue ship to dock reflects that country's new hardline approach and willingness to flout its international obligations but also the breakdown in regional cooperation and solidarity, Human Rights Watch (HRW) said in a report released today ahead of a meeting of EU heads of state next week.
The incident between the Italian and Maltese governments illustrated starkly the need for predictable and fair systems for sharing responsibility, not only for rescue at sea and landing at a port but also for legal processing of arriving migrants and asylum seekers, the human rights organisation said.
The report, "Toward an Effective and Principled EU Migration Policy: Recommendations for Reform," contains concrete recommendations to ensure EU global leadership on refugee protection, uphold the right to asylum, and more equitably share responsibility among EU member states.
"EU governments only seem able to agree on outsourcing responsibility and insourcing misery," said Judith Sunderland, HRW associate Europe and Central Asia director. "Heads of state should take the opportunity of the summit to endorse rights-based migration policies that are both more humane and more efficient."
EU heads of state will meet in Brussels on June 28-29 to discuss migration and asylum policy.
HRW policy recommendations are intended to safeguard the rights of all migrants while allowing EU governments to control their borders.
HRW provides a prescription for a fundamental reset in migration policy at a time when the EU is deflecting responsibility away from its borders. "The EU is making it harder to seek asylum in Europe, creating a hostile environment for migrants and asylum seekers, and threatening the integrity of the international refugee system", Human Rights Watch said.
An effective and principled approach to migration should be grounded in respect for human rights and the right to asylum.
Yet negotiations to reform the Dublin system, which assigns responsibility for processing asylum claims, are stalled, with many proposals likely to increase the current pressure on front-line EU countries rather than to distribute responsibility more equitably.
Numerous EU countries have already adopted or proposed domestic legal or policy changes that limit the rights of asylum seekers and refugees to appeal decisions and to be reunited with their families and that limit assistance. At the same time, EU countries have intensified efforts to prevent arrivals and deter asylum claims, with far-reaching disregard for their significant human rights consequences.
HRW said the 2016 EU-Turkey deal has led to a policy of containing thousands of asylum seekers in inadequate conditions on Greek islands, without noteworthy improvements in protection for refugees in Turkey or significant resettlement to EU countries.
Cooperation with Libyan authorities, and particularly the Libyan coast guard forces, may be nurturing a cycle of violence and detention despite simultaneous efforts to evacuate vulnerable refugees to Niger for resettlement elsewhere and to repatriate migrants not needing protection from Libya to their countries of origin.
At the Council Summit, EU leaders should focus on strategies to minimise dangerous migration journeys while respecting the right to leave any country and acknowledging the myriad drivers of migration, including violence and persecution.
"Efforts to save lives at sea and on land should be a priority, and the EU should expand safe and orderly channels such as refugee resettlement and legal channels for employment and study, while pursuing the safe return of irregular migrants in ways that respect their human rights," the organisation said.
EU governments should invest diplomatic and economic capital in ways that help tackle the abuses that drive migration and that improve protection in regions of origin. The improvements in countries of origin should be based on solutions that would promote human rights, protect refugees, and foster effective development.
Preserving the EU as a protection space for those in need requires forward-looking reform of the Dublin system that distributes responsibility more equitably and provides an incentive to asylum seekers to stick to the constraints of the system, as well as efficient and fair asylum procedures in all EU countries. The use of safe country provisions to reject asylum seekers should be limited and subject to stringent safeguards to prevent what could be unsafe returns.
As EU countries work to increase repatriation of rejected asylum seekers and migrants who are not allowed to remain, the countries should ensure that their procedures are fair, with strong human rights provisions included in readmission agreements, and any detention pending deportation limited to the shortest time necessary.
As a rule, children should not be detained. The EU should offer incentives, rather than threats, to countries of origin to cooperate on returns of their own nationals in the form of more visas for students and workers at all skill levels.
"The divisive political debate in Europe should not obscure the fact that a principled approach could both uphold human rights and manage migration," Sunderland said. "EU leaders should to show genuine leadership and stand up for their shared values and commitments."
Read the full list of recommendations.
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Blažević, Blaževiča oder Blazevic(a) ist der Familienname folgender Personen:

 Alain Blazevic (* 1970), kroatischer Schauspieler
 Alen Blažević (* 1986), kroatischer Handballspieler
 Benjamin Blazevic (* 1995), österreichischer Basketballspieler
 Darko Blažević (* 1984), kroatischer Radrennfahrer
 Davor Blažević (* 1993), schwedischer Fußballtorhüter
 Goran Blažević (* 1986), kroatischer Fußballspieler
 Jakov Blažević (1912–1996), kroatischer Politiker
 Jeļena Blaževiča (* 1970), lettische Weit- und Dreispringerin
 Jurica Blazevic (* 1994), österreichischer Basketballspieler
 Krešimir Blažević (1958–2007), kroatischer Sänger
 Kristīne Blaževiča (* 2001), lettische Leichtathletin
 Miroslav Blažević (1935–2023), bosnischer Fußballtrainer
 Roko Blažević (* 2000), kroatischer Sänger
 Valentina Blažević (* 1994), kroatische Handballspielerin


ATLANTA, GA--(Marketwired - Aug 30, 2017) - GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology company developing human vaccines, announced that its Chief Scientific Officer, Farshad Guirakhoo, PhD, gave a comprehensive presentation of results from studies of GeoVax's NS-1 based Zika vaccine. Dr. Guirakhoo delivered the talk, entitled "A Novel Alternative Approach to Develop a Safe Vaccine for Zika," today during the Advances in Vaccine Technologies session at the Immuno-Oncology Summit in Boston, MA.
Dr. Guirakhoo presented research showing that a single dose of GeoVax's Zika vaccine gave 100% protection in normal mice challenged with a lethal dose of Zika virus (ZIKV) delivered directly into the brain. This is the first report of i) a Zika vaccine based on the ZIKV NS1 protein, and ii) single-dose full protection against ZIKV using an immunocompetent lethal mouse challenge model.
The vaccine was tested at the Centers for Disease Control and Prevention (CDC) in Ft. Collins, CO. with funding by a grant from the CDC. In the study, outbred immunocompetent mice were exposed to a lethal challenge dose of ZIKV delivered directly into the brain. A single dose of GeoVax's NS1 vaccine candidate protected 100% of vaccinated animals. In contrast, 80-90% of sham-immunized control animals died within ~7 days.
GeoVax selected the ZIKV NS1 antigen as the target immunogen for its vaccine, as recent findings indicate a potential risk of disease enhancement using traditional Zika vaccine approaches based on the ZIKV envelope proteins. This "Antibody Dependent Enhancement (ADE) of infection" phenomena has been shown between ZIKV and related flaviviruses, such as West Nile and dengue, in both in vitro and in vivo studies. Mice given dengue or West Nile anti-envelope antibodies were more likely to die in the 2 weeks after the ZIKV infection than mice without these antibodies. An NS1-based vaccine avoids the ADE risk since this protein is not packaged into the virus particles, and is not involved in ADE. This approach holds the promise for a highly effective, yet safer than enveloped based Zika vaccine for humans who live in the areas where the Zika virus co-circulates with other flaviviruses.
GeoVax Labs, Inc., is a clinical-stage biotechnology company developing human vaccines against infectious diseases using its Modified Vaccinia Ankara-Virus Like Particles (MVA-VLP) vaccine platform. The Company's development programs are focused on vaccines against HIV, Zika, hemorrhagic fever viruses (Ebola, Sudan, Marburg, Lassa) and malaria. GeoVax also is evaluating the use of its MVA-VLP platform in cancer immunotherapy, and for therapeutic use in chronic Hepatitis B infections. GeoVax's vaccine platform supports in vivo production of non-infectious VLPs from the cells of the very person receiving the vaccine. The production of VLPs in the person being vaccinated mimics virus production in a natural infection, stimulating both the humoral and cellular arms of the immune system to recognize, prevent, and control the target infection. For more information, visit www.geovax.com.