I'm here on Kauai again visiting with my husband's family. It's usually a very lazy vacation. We have done so many different things on the island after visiting a dozen times.
We usually do the same things like go to Poipu Beach, trek to Mahaulepu, get shave ice, eat cone sushi and tons of local fruit.
Most of the vegetarian/vegan eateries are in Kapaa and my husband's family lives off Omao Rd in Koloa. When the speed limit around the island is usually no more than 40 MPH, it takes a while to get places. Traffic in Kapaa in the afternoon is no fun too. So we only trekked up the eastside to do one Bikram Yoga class. Our attempts at eating were not successful. I wanted to try Gopal's Creperie but it was closed. We also tried to eat at Shivalik's Indian restaurant but unfortunately the waitress was also the hostess, bus boy, and manager of some underage helpers. We ended up eating at Kauai Pasta which was OK.
The highlight of our food this trip was Christmas dinner that was cooked by my sister-in-law who lives in London and also just simple local fruit.
Here's a pic of some longan fruit that we picked up.
It is very similar to lychee and quite easy to eat. You can try to peel it or take a small knife and make a slit. Then press out the little jelly-like fruit into your mouth and eat it. There is a black seed inside that is inedible.
We are off to hike the Hanakapiai Trail on New Year's Day!
Have a Happy New Year and I look forward to being back in Austin soon!


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SCOTUS Slows Vaccine Tyranny; This is Our Dunkirk!
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"The big story to come out of this era, won't be elections and pandemics, it will be...where was the mainstream media in America?
A Bunch of Yankee Doodle Dandies Won the Revolutionary War
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Teachers, Leave Those Kids Alone!
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If you think for one minute that this regime will understand their loss of elections and make a turn to the center, think again. They do not care that the Americans reject their plans for America. Understand history. The vaccine passport is the same as the Yellow Star...
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A Picture of Del Rio is Worth a Thousand Words
by Rob and Andrew
If pictures are worth a thousand words, the pictures coming out of Del Rio, Texas say it all. They are hideous and horrific. We want to think this isn't happening in America, yet it is. We would like to believe we are a humane nation, yet the pictures of border...
Cloaked in Silent Scandals the Media Refuses to Report
by Lt. Joseph Pangaro
Our nation is inundated with one crisis after another. The Biden Administration seems to be bouncing back and forth without a solid purpose, cloaked in silent scandals that the media won't report on. The drone strike on an innocent man and children in Afghanistan, the...
Which Part of Your Genetic Makeup is Jekyll, and Which is Hyde?
by Blaise Vanne
Israel⏤important, as it is one of the most heavily vaccinated countries globally, reported that as of August 2, 2021, 66.9% of Israelis had received at least one dose of Pfizer's injection, and 62.2% had received it two doses. Yet, a day earlier, August 1, the...
Media Focuses on Gabby Petito, Ignores Thirteen Dead American Soldiers
With so much going on in the news, it is easy to lose perspective on what's important and what isn't. This is easily done when the media controls what goes out into the public sphere for discussion. For example, many in the news are attempting to pivot away from the...
COVID Q & A with Dr. Peter McCullough, #6
by Malcolm Out Loud | Oct 8, 2021 | Healthcare, Politics,
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Media reports continue to push a narrative of doom and gloom, despite the positive news that new coronavirus infections in the US fell by over 25% over the past few weeks. But still, when Covid strikes your family, it becomes very personal, and the need for accurate information can make all the difference between life and death. People like Sarah, who wrote to the network with this message: Thank you Malcolm for having the question and answer sessions with Dr. Peter McCullough. My family and I are very appreciative of the knowledge that you share during these difficult times. My question for Dr. McCullough is this: as an unvaccinated person that is afraid of taking the shot for its potential negative side effects, is there any concern for unvaccinated people receiving blood donations from vaccinated individuals?
Here at America Out Loud, we are receiving a tremendous number of questions and comments on a daily basis, and are doing our best to get the answers back into your hands. Dr. Peter McCollough will be joining Malcolm Out Loud in the weeks ahead on the Voice of a Nation to bring a series of these highly important Q & A's to the airwaves. Dr. Peter McCullough is an academic internist, cardiologist, and epidemiologist from Dallas, TX. Dr. McCullough is considered among the world's top experts on COVID-19 pandemic response.
Here are examples of the kind of questions that we will address on the program today, and much more:
– HELP! My son is in the Marine Corp reserve and has to be "fully vaccinated" by Jan 1. He does NOT want the vax but will face dishonorable discharge if he refuses. If he started taking Ivermectin during the month of vaccination, would this help reduce vax injury due to Ivermectin's ability to stop the replication of the spike protein?
– Could you please discuss treatment for long-haul symptoms such as nausea, dizziness, etc? Should patients take Ivermectin again? Steroids?
– My husband wants my two sons, ages 12 and 14, to get vaccinated because he is afraid that if they get sick with Covid, they might suffer from "long covid" after recovering from the acute covid infection. What is your professional opinion? I do not want them to get vaccinated, but I don't know what concrete information or data I can point my husband to, to show him the risks associated with the vaccine are greater than the risk of long Covid.
– Once a VACCINATED person gets sick with Covid… do they then have the full, regular, natural immunity, or would it be compromised in any way?
– I have read the CDC is retiring the PCR test at the end of the year. What test will be used to determine if Covid positive in 2022?
– Can my employer charge me more money for healthcare if I do not have the vaccine?
– The Q&As have been fantastic! Dr. McCullough said several times on the dilute betadine treatment "just a few drops in a glass of water," but can you clarify how many ounces of water? Additionally, betadine has a new gargle product available which is already diluted, but it recommends using no more than 7 days in a row. Would it not be safe then to use daily indefinitely?
– Prior to both Malcolm and Dr. McCullough getting Covid, were either of you doing the Iodine gargle and spit and nasal spray?
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Malcolm is the publisher of America Out Loud, host of 'The Voice of a Nation' and 'Viewpoint This Sunday.' He is the founder of America Out Loud Talk Radio and America Out Loud Podcast Network. Malcolm is a Speaker, Author & Founder of Brink Thinking. His previous career as the 'big idea catalyst' in marketing and creative director of television and radio advertising spanned over two decades.
Malcolm launched America Out Loud in April 2016 after an extensive career in broadcasting and business marketing. He has been a daily voice on the America Out Loud Talk Radio airwaves bringing some of the world's leading newsmakers and informed discussions on the issues confronting our world and nation. For over five years, Malcolm has been a driving force behind America Out Loud's growth, including bringing some of the most insightful programming and online journalism available today. America Out Loud provides an outlet for a vast and growing audience looking for news and analysis without the usual liberal media spin.
First, thanks for all the valuable information. I have a question for Dr. McCullough;
My husband and I got covid at the end of May. He's been forced to get the vaccine to continue working. After reading about side effects and injuries he doesn't want to take it but he'll have to leave his 25 year private practice. Because he has a private practice even his clients ask him if he's vaxed to schedule with him. This is a very difficult decision.
My question, If he gets the vaccine would he lose his natural immunity? he's 53 years old with severe IDD, dyslexia and digestive issues, would the J&J be a better option?
Shannon Davidson
Can those with natural immunity (mine was verified with a positive T detect test, but I was not PCR tested) "catch" the virus again, remain asymptomatic, but still spread it? I know you said those naturally immune won't get sick with COVID a second time, but can we still spread it?
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? Forensic Animation, The JFK Assassination & The Single Bullet Theory
by Dr. Ron Martinelli | Nov 23, 2018 | Politics
This month marks the 55th anniversary of the assassination of President John F. Kennedy in Dallas, Texas. DrRon Martinelli interviews Forensic Animator Angelos Leiloglou of Knotts Labs, CO about his unique forensic research into the dynamics of the shooting of JFK by...
? The Voices of Tomorrow
by Lt. Joseph Pangaro | Nov 22, 2018 | Lifestyle,
With all the talk of the up-and-coming generation and their thoughts on societal changes, politics and the politically correct shift in the nation - we thought it was time to talk some of these young guys to get their take on the state of our nation. Joining us on...
? The Immigration Invasion and Dangers of Judicial Activism
by Dr. Ron and Linda Martinelli | Nov 22, 2018 | Politics,
Activist judges who legislate from the bench are dangerously weakening our national security by empowering illegal aliens and criminals. The illegal immigration invasion and new rules for the White House Press Corps are discussed by DrRon & Linda during our coffee...
? Judge Blocks Trump, AG Whitaker Fury, Prison Reform, Journey with Trump & Thanksgiving Table Talk
by Malcolm Out Loud | Nov 22, 2018 | Politics,
Viewpoint, The MidWeek Report - Some might call it dysfunctional, others a loving tribute to the Bundy Family. A Thanksgiving talk that is sure to open minds and hearts alike. We are also honored to welcome Sid Bowdidge to the table and to tell us about his incredible...
? What About A Second Vote for Conservatives?
by Dr. Carol Swain | Nov 20, 2018 | Politics
Increasingly, large corporations such as Target, Home Depot, Starbucks, Facebook, Twitter, Google and others have become involved in actively involved in using corporate profits to influence the morals and direction of our nation as more corporate leaders become...
Two Paths of Life and Death, Leslee Schneider & Brittany Griffith Form Life Mission
by Malcolm Out Loud | Nov 20, 2018 | Lifestyle,
The birth of a child is one of life's greatest experiences; the emotional and lasting impact has consequences that will last a lifetime and beyond. When that birth becomes compromised with a life-threatening birth defect, your world is immediately forced into a...
? Schumer, Facebook Follies via the NYT and Benefits of an Open Border & The New USSR
Viewpoint This Sunday - A powerful panel starts the discussion at the top of the show on the Acosta media circus and the explosive story of Facebook and Chuck Schumer. We'll take a different view of immigration and borders, along with a big talk on Socialism in...
? Politics and Hilarious Predictions that Didn't Come True
by Dr. Ron and Linda Martinelli | Nov 18, 2018 | Lifestyle,
California mired in the tragedy of wildfires and poor political decisions. Controversial attorney Michael Avonatti busted for domestic violence, CNN reporter Jim Acosta "all about me" controversy continues, Marie Claire 50 most influential women has no conservative...
? How To Kill 14 People Without Saying A Word
by Lt. Randy Sutton | Nov 16, 2018 | Politics
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? Random Violence, Survival and Preparation
by Lt. Joseph Pangaro | Nov 15, 2018 | Politics
The recent elections prove one thing very clearly, we are a nation that is unsure of where it wants to go. The chaos in the Florida election process has revealed potential tampering to get the result that certain people want no matter what the people voted for. A one...
? The American Education System Gone Awry & The Changing Landscape of Border States
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? California Wildfires to Fiery Elections
From the devastating California wildfires, to fiery elections, DrRon and Linda share their thoughts about friends who have lost their homes in Northern California and then move on to the mid-term election ballot screw-ups and possible fraud. Next, they tackle POTUS...
? The Emerging Partisan Divide Between Black Women and Black Men Explained
President Trump's outreach to blacks seems to be yielding some unexpected results. We are witnessing a divide between black men and women when it comes to candidate preferences. In Texas, Ted Cruz got 17 percent of the black male vote and Brian Kemp of Georgia got 11...
Human Trafficking Almost Killed Her, Norma Bastidas Fights Back
"I cannot be called brave and courageous until I do the hardest thing, which is to acknowledge publicly that I am a survivor of sexual human trafficking." And with that, Norma Bastidas changed everything. Growing up in the community of Sinaloa, Mexico; violence,...
? Sessions Out, Election Disputes, Mass Shootings, Mental Illness and Gun-Free Zones
Viewpoint This Sunday - A big powerful program on what is behind these mass shootings and the steps we can and should take to change the trajectory of a society that is losing control. Antifa strikes again - this time at Tucker Carlson's home. What about a RICO...
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The Italian classic: PESTO. It's my favorite sauce in the cookbook. This Oregano Pesto is an exciting twist on the basil pesto we're all familiar with. This recipe has deep, Mediterranean flavors and basically tastes delicious on anything. To begin, try it atop toast, pasta, scrambled eggs, and roasted cauliflower.
2. Lay pistachios flat on a baking sheet and toast for 5 minutes, until lightly browned.
3. In a food processor, combine the toasted pistachios, garlic, anchovy, oregano, and lemon juice. Pulse together. Add olive oil to mixture and pulse to create pesto. Season with salt and pepper.
January 23, 2018 by Corinne L.


Chapter 1.4 - The Process of Life A. Scientific Method 1. Biology is the scientific study of life. 2. The general process of science is said to be characterized by this sequence of stages. B. Observation 1. Scientists believe nature is orderly and measurable. 2. Science also considers that natural laws do not change with time. 3. Phenomena can therefore be understood from observations. 4. Actual science research may also involve chance (e.g., Alexander Fleming's discovery of penicillin). *This principle of science is known as NATURAL CAUSALITY, by its nature it excludes supernatural phenomenon* C. Hypothesis 1. Inductive reasoning allows a person to combine isolated facts into a cohesive whole. 2. A hypothesis is a possible explanation for a natural event - must be testable Examples of hypotheses, check those that are valid and can be tested _____Bluebirds sing to attract mates. _____ Bluebird songs are beautiful. _____ Only male bluebirds sing. _____ Sparrows will leave territories where they hear bluebird songs.. _____ Bluebirds hate sparrows.
D. Experiments/Further Observations 1. Testing a hypothesis involves either further observations or conducting an experiment. 2. Deductive reasoning involves "if, then" logic that predicts what will happen based on the hypothesis. 3. An experimental design is proposed that tests the hypothesis. 4. Scientists may use a model (global warming, but models are not always valid) 5. If a model cannot be tested, it always will remain a hypothesis. E. Data 1. Data are the results of experiments, and are observable and objective. 2. Data are often displayed in a graph or table. 3. Often the data must be inspected for the probability the data could show a relationship by chance; this is a measure of "significance." - statistical analysis F. Conclusion 1. Whether the data support or reject the hypothesis is the basis for the "conclusion." - avoid the word "prove" 2. The conclusion of one experiment can lead to the hypothesis for another experiment. 3. Science findings are reported in scientific journals (peer review). 4. The experiments and observations must be repeatable or the research is suspect. G. Scientific Theory 1. The ultimate goal is to understand the natural world in scientific theories, conceptual schemes supported by a broad range of data. 2. The terms "principle" and "law" are also used for generally accepted theories. Basic theories of biology are: a. Cell theory: all organisms are made of cells. b. Biogenesis theory: life only comes from life. c. Evolution theory: living things have a common ancestor and are adapted. d. Gene theory: Organisms contain coded information that determines their form, function, and behavior.
Other Theories. e. Germ Theory - proposes that microorganisms are the causes of many diseases f. Heliocentric Theory - the sun is the center of the solar system, planets revolve around the sun g. Law of Gravity - masses attract each other H. A Controlled Study a. A variable is a factor that can cause an observable change. b. All variables should be kept constant except the one you are testing b. The experimental - independent variable is the step that is deliberately manipulated c. A dependent variable is component of an experiment that changes due to the experimental variable (yield).
3. Study II a. To test the hypothesis that pigeon pea residues will build up over time and will increase winter wheat production, compared to nitrogen fertilizer, the test is continued. b. All results and conclusions were then reported in a science journal.
4. Study III Observation: Babies are born with severe birth defects, mothers of these babies report taking the drug thalidomide during pregnancy for morning sickness. Question: Does thalidomide cause birth defects? Hypothesis: Thalidomide causes birth defects. Experiment: Group A mice given thalidomide, Group B mice not treated Which group is the control group? __________________________________________ What is the independent variable? __________________________________________ What is the dependent variable? ____________________________________________ In this experiment, mice born from both the control and variable group will not have birth defects. This experiment was performed long before thalidomide was marketed and prescribed to pregnant women. Does these mean that the hypothesis is not supported?
What is a Theory? A Theory is an explanation for natural events that is based on a large number of observations. Can also be referred to as a PRINCIPLE or a LAW. Scientific Theories join together well supported and related hypotheses Its important to realize that theories EXPLAIN what we observe. For instance, the Germ Theory explains why we get sick and why we get infections, in short it uses observation of viruses and bacteria as well as data from those who get ill to create a theory on what causes the illness.
Keep in mind that scientists do not "believe" in something. Instead, they have levels of confidence in explanations for natural phenomena.
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Group rate will be honored for the nights of September 7 – 15, 2018 (based on availability).
Call In: contact reservations at 888-421-1442 and ask for the "NASRA Annual Conference" room block.
Under "Please select your guest type", click on "Attendee".
A credit card number will be required to secure a room out of this block. Cancellations made within 48 hours of arrival will forfeit one night's room and tax.
Reservations must be made by Monday, August 20, 2018, in order to receive the group rate.
through September 8, 2018, under the TEDPA Group. You must make your TEDPA and NASRA reservations under the same exact name – this way we can try to have your room pre-assigned to avoid your needing to change guestrooms. On the date that your TEDPA reservation ends, you will need to go to the hotel front desk to get your key rescanned for the NASRA conference.
All events packages being shipped to the Hyatt must follow the below address label standards to prevent delays. Schedule your shipment to arrive 2 days prior to the event start date to avoid additional storage fees. Include the name of the hotel on-site contact.
Shipping charges must be prearranged and paid by company. The Hyatt does NOT accept a "COD" basis. The Hyatt does not bill shipping charges to a master account.
A labor fee of $70.00 per hour will apply for breaking down/moving pallets.
You are required to pack, tape, and have pre-paid shipping labels taped on boxes and call for a pick up.
The Hyatt offers complimentary shuttle service to MSP airport and the Mall of America.
To Hyatt from Airport Terminal 1: Follow signs to Ground Transportation (near baggage claim) to Hotel Pick-up area. Look for the Hyatt Regency Bloomington–Minneapolis Shuttle Van.
If at Terminal 2, call the Hyatt at 952-922-1234 to request pickup.
To Airport Terminal 1: Shuttle service departs the Hyatt at :00 and :30 of the hour from the Lobby.
Shuttle Service departs the Hyatt at :20 and :50 after the hour, during regular mall hours.


I read this article and found it very interesting, thought it might be something for you. The article is called Why build open-source software? and is located at https://www.indusnet.co.in/why-build-open-source-software/.
What incentive does a commercial organization have to build an open-source software? Why will a programmer spend time and effort in contributing to any open-source product?
These are some questions that we tend to avoid. We are an open-source web development company. Each day of our company is spent working with PHP/MySQL/Apache and Linux. These are all very powerful open-source products. We generate revenue by creating application based on these platform or co-opting them in commercial projects or by customizing an open-source product to individual business needs. But, what is the economic benefit for the programmers who created these applications or extend them continuously?
I recently came across an article from Harvard Business School – Working Knowledge that answered some on these questions.
A programmer will volunteer for a project only when they see a "net benefit" in doing so. "Net benefit" consists both of monetary benefits (immediate benefits) and non-monetary benefits (or delayed benefits). Monetary benefits are easy to visualize if the programmer is working on a commercial project. It will normally include things like Salary and Bonuses.
Non-monetary benefits the author says, consists of improved chances of receiving future job offers, shares in commercial open-source, access to venture capital and ego gratification (my personal favorite). The group of programmers working on an open-source also share very strong alumni relationship with each other and will be available to help in future.
In a commercially created program, outsiders can't really tell who did what. Open source is different. As Lerner and Tirole write, "Outsiders are able to see not only what the contribution of each individual was and whether that component 'worked,' but also whether the task was hard, if the problem was addressed in a clever way, whether the code can be useful for other programming tasks in the future," and so on.
Thus, a programmer can prove that he is competent and his career prospect greatly increases. The commercial world will offer an opportunity only when capability and credential have already been established, whereas the open-source world offers an opportunity to establish that credibility in the first place. The full working paper can be accessed from here.
It seems that all that notion of altruistic programmer is not entirely true and it simply may be a gateway to enter into the commercial world.


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Vancomycin is an antibiotic originally isolated from the bacteria Streptococcus orientalis.
It was discovered in the 1950's but it gained popularity in the 1970's for treating antibiotic-resistant infections, particularly penicillin-resistant staphylococcal infections.
Vancomycin is a glycopeptide antibiotic that stops bacteria from making peptidoglycan, the main component of bacterial cell walls. It is an effective antibiotic treatment against Gram-positive bacteria that have peptidoglycan in their cell walls.
Despite its useful properties, many studies have shown vancomycin therapy damages the kidneys and other organs.
There are ways to safely manage and make dosage adjustments to prevent further harm from occurring.
Uses of Vancomycin
The Food and Drug Administration (FDA) has approved two different kinds of vancomycin.
One type is given by mouth (orally), and another is injected into a vein, or intravenously (IV). The administration method depends on the type of infection and how serious it is.
Oral vancomycin is used to treat infection-induced diarrhea, including cases caused by Clostridiodes (Clostridium) difficile.
Additionally, it is used to treat enterocolitis caused by methicillin-resistant Staphylococcus aureus (MRSA).
However, when vancomycin is used for infections in the digestive system, it cannot get into the blood and treat other infections.
For this reason, vancomycin is injected IV for all other infections besides C. difficile and MRSA enterocolitis.
IV vancomycin treats bacterial infections from methicillin-resistant Staphylococcus aureus , Enterococcus faecalis, and methicillin-resistant Staphylococcus epidermis (MRSE). MRSA and MRSE are both resistant to beta-lactam antibiotics (for example, oxacillin), which are commonly used to treat most staph infections.
Vancomycin can also be used for a variety of other serious or severe infections, including:
Skin and soft tissue infections
Infection of the inner lining and valves of the heart (endocarditis)
Infections in the blood (bacteremia)
Blood poisoning (septicemia)
Lower respiratory tract infections
Osteomyelitis (Infection in the bone)
Vancomycin is also used to treat other conditions off-label, such as:
Intra-abdominal infections due to MRSA
Necrotizing skin and soft tissue infections
Prosthetic joint infections
Prevention of surgical infections
Bacterial infections in the eye (bacterial endophthalmitis)
Prevention of Group B streptococcal infections in newborns
Vancomycin is useful for treating infections in patients who are allergic to penicillin or cephalosporins.
It is important to note that vancomycin and other antibiotics are not effective in treating viral infections.
Dosing of IV Vancomycin
In March 2020, new vancomycin dosing guidelines from leading infectious disease and pharmacy groups were released.
Non-obese adult patients with normal kidney function begin with a dosing of 15 to 20 mg/kg IV (based on the patient's actual body weight), given every 8 to 12 hours.
Non-obese children with normal kidney function between the ages of 3 months and 12 years old are given 60-80 mg/kg/day, with doses divided up and given every 6 hours.
In children who are 12 years and older, the recommended dose is 60-70 mg/kg/day, with doses divided up and given every 6 to 8 hours.
Elderly patients and/or patients with impaired kidney function receive lower doses of vancomycin, while obese patients may receive higher doses.
Vancomycin is processed in the kidneys, and it is important to give enough drug to combat the infection without causing damage.
In order for vancomycin to work correctly, a certain concentration needs to be maintained in the blood. Vancomycin has a narrow therapeutic window, and it is easy to under or overdose a patient.
Blood work is done to ensure levels of the drug remain within this window to prevent organ damage or antibiotic resistance. This also helps to determine when the next dose should be administered to the patient.
The half-life of a drug is how long the body takes to break down one-half of a given dose.
In patients with good renal function, the half-life of vancomycin is between 4 to 6 hours; in patients lacking functional kidneys, the half-life can be as long as is 7.5 days. Every person will eliminate vancomycin at a different rate and dosing can be tailored to an individual patient.
In 2009, guidelines were released stating that patients' dosing should be monitored by trough levels.
The trough level measurement is the lowest concentration of drug in the blood before the next dose is given.
It was previously recommended that patients maintain a trough levels of 10 mcg/mL for all infections; severe or complicated infections required a concentration of 15 to 20 mcg/mL.
This target trough level was chosen to make sure patients were receiving enough drug to kill the infection, but not too much drug that could cause serious damage to the kidneys.
In March 2020, new guidelines were released for vancomycin dosing recommending a shift away from trough levels:
For patients that are not obese: an initial loading dose of 20to 35 milligrams/kilogram (mg/kg) up to a maximum of can be given to a patient with a serious MRSA infection or other illness so that effective serum levels can be reached quickly.
If the patient is obese: the recommended loading dose is 20 to 25mg/kg .
In both cases, the maximum recommended loading dose is 3000mg. After bloodwork is done, a computer program calculates the correct dose. Doctors or other prescribers will give patients the correct amount of vancomycin to reach a target area under the curve (AUC) concentration between 400 to 600 mg*h/L.
Vancomycin Dosing in Patients undergoing Dialysis
When someone develops end-stage kidney failure, their kidneys can no longer function properly.
As a result, the patient needs dialysis, which replicates what the kidneys normally do in the body; this includes removing salt, waste and extra water from the body.
Vancomycin is processed by the kidneys, and this treatment affects drug dosing.
Factors to consider when dosing vancomycin in a dialysis patient include when the dose is given (how often, and whether it is before or after dialysis treatment), and the amount of time in between administration and dialysis treatments.
Studies have shown that dosing to a predialysis concentration of 10 to 20 mg/L results in an AUC of 250 to 450 mg*h/L, which is lower than the target AUC of 400 to 600 mg*h/L. As a result, predialysis concentrations should be maintained at 15 to 20 mg/L to achieve this target AUC.
It is recommended to give maintenance doses of vancomycin with each dialysis session so that an effective concentration of drug remains in the blood to treat infections.
Larger doses may need to be given in between dialysis sessions to prevent serum concentrations of the drug from dropping.
To test for serum concentration of vancomycin, wait at least 2 hours after dialysis treatment to allow the drug to enter the blood from tissues.
Side Effects of IV Vancomycin
You can find our full list of Vancomycin Side Effects here. Common adverse side effects of IV administration of vancomycin in particular include:
Low blood pressure (hypotension)
Muscle pain or spasms in the chest and back
Allergic reactions, such as anaphylaxis or hives
Shortness of breath or wheezing
Other adverse effects that are less common include:
Drug fever
Inflammation of a vein at the injection site (phlebitis)
An increase in white blood cell count (eosinophilia)
Red Man Syndrome
When vancomycin is administered too quickly intravenously, red man syndrome can develop.
Symptoms tend to begin 4 to 10 minutes after administration, including:
Itching or uncomfortable skin (pruritus)
Red skin rash on the upper body, face, and neck
Between 3.7% to 47% of patients develop red man syndrome. The faster the infusion of vancomycin, the more likely a patient is to develop the syndrome.
The most severe cases occur in children and patients who are 40 years old or younger.
Antihistamines, such as cimetidine and diphenhydramine, can be given before infusion to help prevent red man syndrome from occurring.
However, the most effective method is administering the drug slowly over 60-120 minutes.
Nephrotoxicity of Vancomycin
Vancomycin has been shown have nephrotoxicity, which can lead to acute kidney injury (AKI).
This is most likely caused by the drug stopping blood flow and oxygen from reaching the kidneys.
Patients are at a higher risk for developing AKI if they have underlying renal function impairment, use other nephrotoxic medications, are elderly, or are dehydrated. There are multiple ways that AKI can be defined.
An increase in serum creatinine of >0.5 mg/dL or
A 50% increase from baseline in two consecutive daily readings, or
A decrease in calculated creatinine clearance of 50% from baseline on two consecutive days in the absence of an alternative explanation.
Newer studies suggest that a more sensitive threshold of an increase in serum creatinine >0.3 mg/dL over a 48-hour period may be an indicator of AKI.
A safe way to determine vancomycin dosing is to base it on a patient's estimated creatinine clearance; this helps prevent overworking the kidneys.
The main function of the kidneys is to filter the blood and remove toxins from the body.
When a patient has renal function failure (their kidneys no longer work), hemodialysis can be done.
This procedure uses an artificial kidney, or dialyzer, to clean the blood.
An infection in the blood called bacteremia can develop during hemodialysis treatment and vancomycin is used to treat it. However, these patients cannot properly process the drug, and a dose adjustment needs to be made so it does not cause any further damage.
Ototoxicity of Vancomycin
Vancomycin has been shown to induce ototoxicity, an ear condition where the auditory nerve and cochlea are damaged.
It rarely occurs when vancomycin is given on its own; however, it is quite common in patients taking high doses as monotherapy or if it is combined with other ototoxic medication (aminoglycosides, loop diuretics, and anticancer drugs).
Patients who have underlying hearing loss conditions are also commonly affected.
Vancomycin treatment should be stopped if patients lose their hearing or balance, or experience ringing in the ears (tinnitus).
In some cases, ototoxicity induced by vancomycin treatment may be irreversible.
Vancomycin Trough Levels: Upcoming Therapeutic Drug Monitoring Recommendations
How Can We Prepare Physicians for AUC?
Hale CM, Seabury RW, Steele JM, Darko W, Miller CD. Are Vancomycin Trough Concentrations of 15 to 20 mg/L associated with increased attainment of an AUC/MIC ≥ 400 in Patients with Presumed MRSA Infection? J Pharm Pract. 2017;30(3):329-335. https://www.ncbi.nlm.nih.gov/pubmed/27074786
Hazlewood KA, Brouse SD, Hall RG. Vancomycin-Associated Nephrotoxicity: Grave Concern or Death by Character Assassination? Am J Med. 2010;123(2):182.e1-182.e1827. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813201/
MedlinePlus Drug Information. Vancomycin Injection. Revised April 15, 2016. Accessed April 7, 2020. https://medlineplus.gov/druginfo/meds/a601167.html
Levine, DP. (2006). Vancomycin: A History. Clin Infect Dis. 2006;42 Suppl 1:S5-S12. Accessed April 8, 2020. https://www.ncbi.nlm.nih.gov/pubmed/16323120
Patel S, Preuss CV, Bernice F. "Vancomycin." StatPearls [Internet]. 28 February 2020. Accessed April 7, 2020. https://www.ncbi.nlm.nih.gov/books/NBK459263/
Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, et al. Therapeutic Monitoring of Vancomycin: A Revised Consensus Guideline. Am J Health Syst Pharm [Epub ahead of print.] Accessed April 7, 2020. https://www.ncbi.nlm.nih.gov/pubmed/32191793
Taylor ME, Allon M. Practical Vancomycin Dosing in Hemodialysis Patients in the Era of Emerging Vancomycin Resistance: A Single-Center Experience. Am J Kidney Dis. 2010;55(6):1163-1165. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019019/
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Mercedes-benz to Release New Black Series
One way of increasing the popularity and value of a car is of course to design them to be able to perform at an exceptionally high level. Another way to increase the selling point of a car is to make it rare and this means that you would be releasing only a limited number of a particular model into the auto market.
Car manufacturers do this to increase the popularity of the model or to commemorate a milestone. Mercedes-Benz, for example, has increased the already high value of their cars with the successful release of the first Black Series. This year, the German company hopes to continue the success of the Black Series with the announcement of the development and nearing release of the Mercedes-Benz CLK63 AMG Black Series.
Last year, Mercedes-Benz released a Black Series which was based on the Mercedes-Benz SLK55 AMG. The said limited edition model was produced in a very limited number, making it an instant classic to the view of some auto enthusiasts. This year though, the Black Series of the CLK63 AMG will be marketed to a wider area therefore more of this vehicle will be produced compared to last year's Black Series.
The Black Series of the four-seater coupe is said to have been inspired by the Mercedes-Benz's Formula One Safety Car. What sets the Black Series CLK63 AMG apart from the standard model is that it packs more power among other things.
The past Black Series edition was only marketed in Europe. This year though, the 2008 Mercedes-Benz CLK63 AMG Black Series will be sold both in and outside of Europe. The said limited edition model will hit showrooms by the latter part of 2007. One of the countries outside Europe that the 2008 Black Series will be made available to is Australia. The inspiration for the Black Series of the AMG lineup of Mercedes-Benz is the Formula One safety car which sets the pace for Formula One cars when a crash on the track pose a threat to the speeding race cars. The Black Series will be the top of the line entry in the AMG model lineup.
The exterior styling sets the Black Series car from the standard ones. Design cues on the outside gives the limited edition series an aggressive look thus increasing its aesthetic value. The deep front spoiler of the Black Series lowers its coefficient of drag making the car more aerodynamic than standard CLK63 AMG. The over emphasized wheel arches, extra ducts on the front fender, and a slightly redesigned bumper gives the Black Series a look unique to itself.
As far as the weight of the car is concerned, Mercedes-Benz is yet to divulge that piece of information. Although one can infer that the Black Series will weigh less than its siblings due to the fact that carbon fiber and other composite materials are used in the construction of the body of the Mercedes-Benz CLK63 AMG Black Series. The lightweight and cool looking material will surely make the Black Series a lot more expensive than standard CLK63 AMG. Speculations around the auto industry puts the price of more than $250,000 to the unreleased limited edition series.
What powers the four-seater coupe is Mercedes-Benz's humungous 6.2-liter V8 engine. The V8 can produce as much as 500 horsepower and that sure is an improvement over the standard engine used in the standard Mercedes-Benz CLK63 AMG. That power represents a 25 percent increase in horsepower. That amount of power is transferred from the engine to the drive wheels via a precision engineered seven-speed 7G-Tronic automatic transmission featuring limited slip differential.
The gear box efficiently transfers power from the engine to the wheel s with limited waste of power. That amount of power can only be kept in check by equally highly efficient brake components such as an . With all that power, the 2008 Mercedes-Benz CLK63 AMG Black Series is reported to reach speeds of 100 kilometers per hour from a standstill in just 4.3 seconds.
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Xylanases are known to improve dough machinability and dough-handling properties for bread, buns and rolls. Xylanases produce baked goods with better volume, crumb structure and bloom.
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Engineers are deploying a trash collection device. It is designed to corral plastic litter floating between California and Hawaii. This is an attempt to clean up the world's largest garbage patch. It is in the heart of the Pacific Ocean.
The device is a 2,000-foot long floating boom. It is being towed from San Francisco to the Great Pacific Garbage Patch. The "patch" is an island of trash. It is twice the size of Texas.
The system was created by The Ocean Cleanup. It is an organization founded by Boyan Slat. He is a 24-year-old innovator. He is from the Netherlands. He first became passionate about cleaning the oceans when he went scuba diving. He was 16. In the Mediterranean Sea, he saw more plastic bags than fish.
"The plastic is really persistent. It doesn't go away by itself. The time to act is now," Slat said. He added that researchers with his organization found plastic going back to the 1960s and 1970s bobbing in the patch.
The boom is a buoyant, U-shaped barrier. It is made of plastic. It has a tapered 10-foot deep screen. It is intended to act like a coastline. It is designed to trap some of the 1.8 trillion pieces of plastic. Scientists estimate the pieces are swirling in that gyre. But they believe it is allowing marine life to safely swim beneath it.
The cleanup system has solar power lights and cameras. It has sensors and satellite antennas. It will communicate its position at all times. This will allow a support vessel to fish out the collected plastic every few months. Then it can transport it to dry land. There it will be recycled, said Slat.
Shipping containers will be filled. They will have fishing nets and plastic bottles. They will have laundry baskets and other plastic refuse. All will be scooped up by the system. It was deployed Saturday. It is expected to be back on land within a year, he said.
Slat said he and his team will pay close attention to whether the system works well. They want to know whether it withstands harsh ocean conditions. These include huge waves. He said he's most looking forward to a ship loaded with plastic coming back to port.
"We still have to prove the technology. It will then allow us to scale up a fleet of systems," he said.
The Ocean Cleanup has raised $35 million in donations. These helped to fund the project. These included funds from Marc Benioff. He is chief executive of Salesforce.com. Funds also came from PayPal co-founder Peter Thiel. Ocean Cleanup will deploy 60 free-floating barriers in the Pacific Ocean. They will be sent out by 2020.
The free-floating barriers are made to withstand harsh weather conditions. They are also made to stand up to and constant wear and tear. They will stay in the water for two decades. In that time they will collect 90 percent of the trash in the patch, he added.
George Leonard is chief scientist of the Ocean Conservancy. It is a nonprofit environmental advocacy group. He says he's skeptical Slat can achieve that goal. His concern: even if plastic trash can be taken out of the ocean, a lot more is pouring in each year.
"We at the Ocean Conservancy are highly skeptical. But we hope it works," he said. "The ocean needs all the help it can get."
Leonard said 9 million tons of plastic waste enter the ocean yearly. A solution must include a multi-pronged approach. This includes stopping plastic from reaching the ocean. It also includes more education so people reduce consumption of single use plastic containers and bottles.
"If you don't stop plastics from flowing into the ocean, it will be a Sisyphean task," Leonard said. He cited the Greek myth of a task never completed. He added that on September 15 about 1 million volunteers around the world will collect trash from beaches and waterways. This is part of the Ocean Conservancy's annual International Coastal Cleanup. Volunteers last year collected about 10,000 tons of plastics worldwide over two hours, he said.
Leonard also raised concerns that marine and wildlife could be entangled by the net that will hang below the surface. He said he hopes Slat's group is open with its data and shares information with the public. He wants them to share what happens with the first deployment.
The system will act as a "big boat that stands still in the water." It will have a screen and not a net so that there is nothing for marine life to get entangled with. As an extra precautionary measure, a boat will carry marine biologists. They will be deployed to make sure the device is not harming wildlife, Slat said.
How could so much trash accumulate?
All this trash could have accumulated over the years of people throwing their trash into the ocean.
There are whirlpools in the ocean that can gather a lot of stuff. Trash is one of those things. It gathers up and so much of it will create a giant island.
Trash in the Pacific Ocean is a big problem because there are animals in there and they can die i hope that they could clean up the trash quickly.
People throw their trash into rivers, lakes, oceans, and more. All that trash is making the air bad to breathe. Without no good air we can't live because we need air to live because we use it to breathe everyday.
i think more people should take better care of their community's.
I can't believe thew island is twice the size of Texes.
Well its easy, people dont care! People throw trash in the ocean cause they are rude. People never think about fish and other things. People don't care when they throw stuff in the ocean. Even when I was on the beach I was scraped badly by a BIG plastic frisbee.
I knew the garbage patch was big but i never knew it was twice the size of texas. Slat is inspirational.
It is so horrid to think that we have an island made of trash in the middle of the ocean. there is even trash there from the 1960's! That is truly horrible!


The Sahel is the ecoclimatic and biogeographic zone of transition between the Sahara desert in the North and the Sudanian Savannas in the south. It stretches across the North African continent between the Atlantic Ocean and the Red Sea. The Arabic word sāḥil ساحل literally means "shore, coast", describing the appearance of the vegetation of the Sahel as a coastline delimiting the sand of the Sahara.
The Sahel covers parts of the territory of (from west to east) Senegal, southern Mauritania, Mali, Burkina Faso, southern Algeria, Niger, northern Nigeria, Chad, Sudan (including Darfur and the southern part of Sudan), northern Ethiopia and Eritrea.
The Sahel is 5,400 km (3,400 mi) from the Atlantic Ocean in the west to the Red Sea in the east, in a belt that varies from several hundred to a thousand kilometers (620 miles) in width, covering an area of 3,053,200 square kilometers (1,178,800 sq mi). It is a transitional ecoregion of semi-arid grasslands, savannas, steppes, and thorn shrublands lying between the wooded Sudanian savanna to the south and the Sahara to the north.
The topography of the Sahel is mainly flat, and the region mostly lies between 200 and 400 meters elevation. Several isolated plateaus and mountain ranges rise from the Sahel, but are designated as separate ecoregions because their flora and fauna are distinct from the surrounding lowlands. Annual rainfall varies from around 200 mm in the north of the Sahel to around 600 mm in the south.
The first instances of domestication of plants for agricultural purposes in Africa occurred in the Sahel region circa 5000 BC, when sorghum and African rice began to be cultivated. Around this time, and in the same region, the small Guinea fowl were domesticated.
Around 4000 BC the climate of the Sahara and the Sahel started to become drier at an exceedingly fast pace. This climate change caused lakes and rivers to shrink rather significantly and caused increasing desertification. This, in turn, decreased the amount of land conducive to settlements and helped to cause migrations of farming communities to the more humid climate of West Africa.


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Lightning Round: The future of trading cards and the NHL
Will they be the latest sport to join the move to Fanatics?
By JustinG. Aug 26, 2021, 9:00am EDT
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The NHL and Upper Deck. It's a relationship that goes back more than 30 years. Which, as you may know, is longer than the Tampa Bay Lightning have been in the league. Born in the heyday of the junk wax era when manufacturers churned out enough cardboard to build a million houses of cards, the partnership has weathered the storm of rivals (Score, Topps, Panini have all gone by the wayside in regards of hockey cards) and the ups and downs of the market. Now their relationship is likely to be challenged once again. A seismic change is tearing through the trading card world as Fanatics has been gobbling up exclusive licenses with the leagues and player associations of major league sports.
First it was MLB reportedly agreeing to an exclusive deal with Fanatics starting in 2026, ending a 70-year run for Topps as the go-to manufacturer of baseball cards. The MLBPA agreement with Fanatics will supposedly start in 2023. Then it was the NBA, NBAPA, NFL, NFLPA following suit a few days later, giving Fanatics exclusive rights to three of the big four sports in North America.
This has been received by folks in the hobby about as well as ads on sweaters has been by hockey fans. There has been a lot of angry Tweets and bold declaration thrown around over the last few days. If people are to be taken at their word, there should be a lot of card collections for sale soon as a vast swath of folks have declared they are leaving the hobby for good this time.
I'll be honest with y'all. When I first heard about Topps getting shut out of the baseball card market I was a little upset. Some of my earliest memories revolve around baseball cards, notably buying a pack of 1982 Topps at an army PX in Germany and later trading cards with neighborhood friends in my backyard when we had moved back to the States (which probably would have been me swapping 1985 John Shelby's for Roger Clemens' rookie cards - I was not a smart child).
Also, as a middle aged guy, my immediate reaction to all things involving change is, and always must be, "Why? Why would you ruin my childhood by doing something different? Change is bad!" I've settled down and stopped being an obstinate ass over the last few days and have developed a wait-and-see attitude about it. After all, it's five years away, who knows what can happen over that time.
That brings us to hockey. As of press time there have been no rumors about the NHL jumping ship and joining their sports siblings under the Fanatics umbrella. The league and players association renewed their agreement with Upper Deck in 2019, agreeing to a "multi-year, exclusive deal". One of the more annoying things about this industry is that the length of these agreements is always a mystery. Kind of like the length of contracts for general managers and coaches.
Upper Deck has been exclusive with the NHL since the 2014-15 season, ending a nice underdog run by Panini who had been their main competitor this century. Of course, when leagues started to sign exclusive deals with the manufacturers back in the early 2000's, that was supposed to signal the end of the sports card world as we knew it, but things seem to be humming along just fine since then.
Why would the NHL or the NHLPA want to jump on the Fanatics bandwagon? Money, of course. If Fanatics is throwing the cash around to corner the sports card market, could the players and owners be tempted into a grabbing the loot after the financial struggles of the past few years?
While the exact details of the financial arrangements with the others sports hasn't been unveiled (in fact Fanatics has yet to officially comment on the acquisitions) it had to be a heck of a chunk of change because they reportedly didn't even give Topps a chance to make a counteroffer.
On the other side of the table, Fanatics would gain a foothold in a sport that has a tremendous potential for growth. One thing about the sports card market is that basketball and football cards(baseball to a lesser degree) have experienced an explosion in popularity and value over the last two years. Hockey, not so much. Sure, Wayne Gretzky rookie cards are selling for all time highs, but that hasn't really carried over to the current superstars like it has in other sports. If you go to Target or Wal-Mart you are likely to find hockey cards on the shelves, the same goes for the local card store (LCS).
With the new television deal with ESPN and Turner, and a crop of pretty good young players like Brayden Point and some guy in Canada named Conner McDavid, hockey should be increasing in popularity over the next few years. Fanatics, who is buying the rights to basketball and football cards at a high price, could find growth value in hockey cards by buying low.
The NHL could also use this as leverage in their next round of negotiating with Upper Deck. Having lost out on baseball, Topps could be interested in jumping back into the hockey market (and make some more sweet, sweet Stadium Club cards). The same goes for Panini.
Losing the rights to the NHL would not be great for Upper Deck. Unlike Topps (candy, F1 and soccer cards, as well as gift cards) and Panini (soccer stickers and European leagues), they really don't have much to fall back on financially if they can't sell hockey cards. They started as a trading card company and have remained true to that pretty much since day one.
There is a better than average chance that Fanatics ends up buying a company like Upper Deck or Topps. After all, as excellent as they are at distributing sports merchandise, they don't currently have the facilities to actually produce trading cards. So making an offer for Upper Deck would solve a couple of problems for them.
Is there a drawback to Fanatics owning exclusive card rights to all four major North American sports? Sure, more than one. A lack of competition can lead to a lack of creativity. As a company that specializes in distribution, they could cut out the middle men like LCS's and retail markets and sell product directly to fans. Card sets that we come to rely on like Young Guns rookie cards could disappear and replaced by...well, who knows what?
It's still way to early to mourn the demise of Upper Deck Hockey Cards. Still, it's something to keep an eye on if you're interested in the hobby.
Lightning / Hockey news
Liz Koharski is the director of hockey administration for the Tampa Bay Lightning. She is also just the 17th woman to have her name engraved on the Stanley Cup. The Lightning executive was etched into history in recognition of the club's victory in 2020. [Liz Koharski is 17th woman to have her name on the Stanley Cup]
It's official. Ben Thomas will not be suiting up for the Lightning next season. As was reported a few weeks ago, he has signed with Leksands IF. The addition of Zach Bogosian bumped Thomas' chances of making the squad down quite a bit so he's taking his talents to Sweden. All of us (well, almost all of us) at Raw Charge wish him the best of luck in his future endeavors. [Elite Prospects Twitter]
Pat Maroon chatted about his third Stanley Cup in a row and what kind of example he can set for the next generation of hockey players. [Pat Maroon talks about his Stanley Cup three-peat]
Our official blog Auntie, Alexandra Ackerman, chats about the Crunch's offseason and the upcoming prospect showcase. Why yes, she is quite excited by the return of Gabriel Dumont. [Syracuse Speaks]
The fine folks over at Bolts By the Bay have submitted their Mount Rushmore of Lightning players over the course of the franchise history. How they left off Olaf Kolzig is a mystery that will haunt me for days. [Tampa Bay Lightning Mount Rushmore]
Lightning Round: Bolts prospect makes Olympic Men's Hockey roster for Team USA Is this the best roster the USA Men's team could've made?


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Inspired at early age, 'frum' writer targets younger audience
April 22, 2015, 8:09 pm 0 Edit
Chani Altein is co-director of Chabad of Pittsburgh. (Photo provided by Chani Altein)
When asked what she wanted to be when she grew up, then-fourth-grader Chani Altein would reply with confidence: "I want to be an author."
Now, some years later, after having penned and published six young-adult novels and four picture books, Altein looks back fondly on her early days of writing poetry at the New Haven Day School.
"I had a fourth-grade general studies teacher who made me feel so good about my writing, I wanted to do it for real," she recalled.
Altein, co-director of Chabad of Pittsburgh and the mother of five children ranging in age from 2 to 12, has found a niche market in what she calls "frum literature," and she has a devoted following of Jewish children and teens who frequently write her letters telling her how much they love her work.
Her latest novel, "Mimi in the Middle," published by Judaica Press last month, tells the story of a young Orthodox girl with younger twin brothers and older twin sisters who struggles with the pressures of being a middle child and learns a lesson about "going the middle way, and not being too extreme on either side," Altein said.
Altein wrote her first book when she was just 21, working as a preschool teacher in Park Slope and frustrated by the lack of an engaging aleph-bet book for young children.
When she saw how much her students enjoyed the rhythm in the popular alphabet book "Chicka Chicka Boom Boom," she was inspired to create a similar story to teach the Hebrew letters.
Hachai Publishing loved her manuscript, Altein recalled, but there was one catch.
"I wrote it in the Sephardic pronunciation — aleph bet — and they said their market says aleph-bais," she said. "I had to switch it all around. That was a challenge."
But it was a challenge she was up for, and the result was "The Aleph-Bais Trip on the Aleph-Bais Ship," illustrated by Baruch Becker, who has also done work for Disney. The book was well received and was sold in Judaica stores across the country.
A year later, Altein wrote her second picture book, which she submitted to publisher ArtScroll. An editor there told her she didn't see the story as a picture book but suggested Altein turn it into a chapter book.
By then, Altein was living in Pittsburgh and, having no summer plans, could devote that time to writing her first young adult novel. Although ArtScroll did not respond to her submission of her completed manuscript, Judaica Press embraced it and has since published five of her six novels.
Writing for "religious Jewish publishers" poses unique challenges, according to Altein. Because their readers sanction only particular behaviors, the books they publish have to reflect only those behaviors.
"You have to know what they're looking for," Altein said. "For example, the characters can't be too mean. My challenge over time has been making my characters true to life but still acceptable to the frum market. If I have someone gossiping in the book, her words get totally revised."
In real life — even in the frum world — young girls are sometimes mean, Altein noted, and often do things such as talk back to their parents. While Altein can intimate these types of behaviors in her books, she has to be careful not to go too far, she said.
"The characters can't be overtly disrespectful," Altein explained. "As an author, I had to figure out how to do that."
Particular words are also taboo and pose another challenge to the writer. In "Mimi in the Middle," for example, Altein had written in a pregnant sister-in-law but had to remove any mention of pregnancy. In another book, Altein had written about girls traveling together to Florida for vacation — which happens sometimes in real life, she noted — but had to revise her work as the publisher did not think the idea of two girls traveling together to Florida would be acceptable to its readers.
"I understand where they are coming from," Altein said. "They have readers they need to please."
In Altein's last novel, which she self-published, she included the character of a rebellious teenager but "had to do it in subtle ways," she said.
"I couldn't say 'drugs,' or 'boys,'" Altein explained. "I had to just use little things to hint at rebelling such as highlights in her hair."
Altein spends about two and half hours writing and revising each page, she said, and as the mother of five and co-director of Chabad, she has to squeeze in writing time between programming responsibilities and child rearing.
But while being a mother has limited the time Altein has to write, she does benefit as an author from listening to her own children, she said.
"Now, when I write about kids that are my kids' ages, I can be true to their voices," she said. "They are a good frame of reference."
Toby Tabachnick can be reached at tobyt@thejewishchronicle.net.


Can you believe that the paint used on cars inspired the invention of nail polish in the 1920s? Or that people have been making hair dyes for thousands of years, using everything from boiled walnuts to gold powder? Get ready to learn the strange stories behind inventions you use every day. From the woman who invented "kissproof" lipstick to the role toothpicks played in the creation of Q-tips, you'll find out how we got the beauty inventions that help us look great.
Recounts the stories behind the invention of some commonly used beauty products, such as Q-tips, kissproof lipstick, nail polish and hair dye.
hoopla:MWT11805609|eAudiobook|Audio Books|Unabridged.|English|Lerner Publishing Group ,|2014.|1 online resource (1 audio file (28 min.)) : digital., ils:CARL0000638930|Book|Books||English|Lerner Publications,||32 pages : illustrations ; 26 cm.


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Brooklyn Nine-Nine star Terry Crews has filed a crime report alleging a sexual assault that he says occurred at a Hollywood event last year. Los Angeles Police confirm to Deadline that Crews met with officers today to file the complaint.
"We can confirm that a crime report was completed at the LAPD Hollywood division station," said an LAPD spokesman, who said he could not reveal the name of the alleged assailant.
Crews is a WME client. Adam Venit, head of the agency's motion picture group and one of its most senior agents, has been on leave as WME investigates sexual harassment allegations made by a client. Venit was identified in reports as the exec Crews was referring to in the red-carpet incident that the actor says took place in full view of his wife.
Venit's roster of clients includes Emma Stone, Adam Sandler and Sylvester Stallone. Dustin Hoffman and Brett Ratner, who also have been accused of sexual improprieties, are also clients.
Crews is the latest in a wave of accusers who have come forward or gone to the police in the wake of the Harvey Weinstein scandal to report allegations of sexual assault and sexual harassment.
Dominic Patten and Erik Pedersen contributed to this report.


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Argentine officials visit Rice
A delegation of top Argentine officials visited Rice June 8 for a meeting with President David Leebron and others from the university community to explore opportunities for collaboration, such as student and faculty exchange, study abroad programs and research.
Pictured (left to right) are Argentine Deputy Consul General Ramiro Lascano; Consul General Gabriel Volpi; Nicolas Shumway, the Frances Moody Newman Professor Emeritus of Spanish and Portuguese at Rice; Leebron; Jorge Argüello, Argentine ambassador to the United States; Rosario Sa Martinez, marketing and recruitment specialist for Rice's Engineering Professional Master's Program (EPMP); Caroline Levander, Rice's vice president for global and digital strategy; Mark Jones, the Joseph D. Jamail Chair in Latin American Studies at Rice; Fred Higgs, vice provost for academic affairs, director of the Rice Center for Engineering Leadership and the John and Ann Doerr Professor of Mechanical Engineering; Seiichi Matsuda, Rice's dean of graduate and postdoctoral studies; Adria Baker, associate vice provost for international education and executive director of the Office of International Students and Scholars at Rice; Agustina Fernandez Moya, director of EPMP and the organizer of the meeting; and Deputy Consul Alejandro Anibal Garcia. (Photo by Jeff Fitlow)


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Far Right Elects Another Lesbian Candidate
Candidate on Ruzicka: 'Get A Leash on Her'
Patty Henetz, The Salt Lake Tribune
Bryan Irving has few illusions that he might have won his race for House District 30. But he is angry that Gayle Ruzicka injected herself into the campaign, and called on the Republican Party to repudiate her tactics.
"With people like Gayle Ruzicka involved, it almost makes me want to be a Democrat," Irving said Wednesday. "I don't think I would have won. But she cost me about 10 points. Somehow the party has got to get a leash on her."
Democrat Jackie Biskupski on Tuesday defeated Irving, a Republican, by a 2-1 margin, becoming Utah's first openly gay legislator.
Ruzicka, who lives in Utah County and heads the extreme right-wing Utah Eagle Forum, in September announced she would work to defeat Biskupski on moral grounds.
Irving said he tried to make it clear he wanted no help from Ruzicka, who he said never even paid him the courtesy of a phone call. She did, however, raise $3,000 to pay for a homophobic flier mailed over the weekend to 6,000 District 30 residents.
The flier claimed that homosexuals subvert fidelity in marriage, lure young people, scorn traditional morals and openly break the laws they find irrelevant.
As a tactic it backfired, said district resident Doug Duncan. "It sickened me," said Duncan, a registered Republican who voted for Biskupski. "You want to say, 'Oh, just shut up.' "
Irving said he took heat for the letter. "Everybody thinks it was me," he said. "I don't need that... It's not the legacy I want to leave."
Joe Hatch, Salt Lake County Democratic Party chairman, said the mailing only cemented Biskupski's likely victory in the solidly Democratic district that includes Sugar House, part of South Salt Lake and portions of Murray and unincorporated Salt Lake County. "I knew she was going to win. It was just nice it was a landslide," Hatch said.
Utah Republican Party Executive Director Spencer Stokes said "there is no doubt [the flier] may have hurt" Irving.
"I'm sure Jackie will represent the constituents of her district well," Stokes added. "The concern we have and others have is that she will be pressured by special-interest groups."
Throughout her campaign, Biskupski has steadily maintained she has no such agenda. But fighting perception is part of being a gay candidate, said Kathleen DeBold, spokeswoman for the Victory Fund, a national gay political organization.
"Someone like Jackie has two campaigns: one against the opponent and one against the stereotype," DeBold said. "It was the race against the stereotype that was harder for her to fight."
Anti-gay tactics were employed in campaigns around the country, said Rebecca Isaacs, political director for the National Gay and Lesbian Task Force.
Of the 50 candidates endorsed by the Victory Fund, 36 won despite anti- gay campaigning. In Wisconsin, Democrat Tammy Baldwin became the first non- incumbent openly gay person to win a seat in Congress.
Isaacs said political gay-baiting started over the summer, when a spate of newspaper ads and stories appeared featuring people who claimed to have returned to heterosexuality after being gay.
Biskupski saw parallels between the anti-gay tactics and the Republicans' $10 million anti-Clinton campaign widely credited with helping Democrats in national races.
"People in general are tired of hatred, tired of people trying to divide the communities rather than unite them and make them strong," she said.
Biskupski and Irving acknowledge there is work to be done to heal division in District 30 brought on by a campaign neither of them wanted. "It's a sunny day out and I'm doing fine," Irving said. "If Jackie needs my help, I'm glad to give it."


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LET'S MAKE AN UNWATCHABLE COLLEGE FOOTBALL GAME
AND I'LL STILL WANT TO WATCH IT
By ActionCookbook@actioncookbook Jun 3, 2019, 12:05pm EDT
Share All sharing options for: LET'S MAKE AN UNWATCHABLE COLLEGE FOOTBALL GAME
We're at the absolute nadir of the college football calendar — it's been almost five months since any of us were able to watch a new game, and we're still two and a half months away from play starting back up.
We're desperate for a hit.
I'd take anything at this point. A Thursday night AAC game. A Conference USA tilt between two bottom-dwellers. A Tennessee game. I'd watch anything.
This got me to thinking, as I do: what would make the most unwatchable game possible? Well, it's time to try. In the grand spirit of internet challenges, I'm giving you $15 to construct the worst, most god-awful, absolutely unwatchable college football game possible. And I bet you, here in early June as we are, that I'd still watch at least half of it.
I. TEAMS
It's not just enough for these teams to be bad. They've got to be bad, bleak, and play an utterly uninspiring, mirth-free form of football. Take Arkansas, for instance. They were terrible last year, going 2-10. But they're Arkansas, and they've still got some chaos demons lurking around the program, so you never know when something wacky, fun and terrible might happen with them. They are not on this list.
Also, we're going to need two teams here, so I'll halve the prices.
$0.50 Cal
$0.50 Baylor
$1 Louisville
$1 UNC
$1.50 Kansas
$1.50 Vanderbilt
$2 Illinois
$2 Oregon State
$2.50 Rutgers
$2.50 UConn
Note: if you end up with $0.50 left, you can add in "both teams are bowl banned"
II. VENUE
Even if the teams are bad, you've still got the joy and tradition of a college football gameday experience, though, right? NOPE. We're taking these teams out of their home environments and putting them somewhere sterile, lifeless, and absolutely devoid of excitement
$1 Charlotte
$2 UCF's Spectrum Stadium, the crowd will be constantly reminded that both of the teams playing are in a major conference and UCF is not (note: if selected, UConn will be placed in the ACC)
$3 Marlins Park
$4 Michigan Stadium, but tickets are only sold to the fans of the teams playing and so it's only people willing to pay to travel to Ann Arbor to see the game, there will be no one else there
$5 Levi's Stadium
III. WHAT CHANNEL IS IT AIRING ON?
Sometimes you'll watch a game just because it's on ESPN or ABC, right? The noon game isn't always a winner, but you've got broadcast-level production values. Again, no. You're going to have to really scan the channel guide to find this, and there will be three cameras.
$1 CBS SPORTS NETWORK
$2 THE ACC NETWORK
$3 FACEBOOK
$4 SoonerSports.TV, it's a pay-per-view game and you're paying Oklahoma
$5 SOMEONE'S JUST TEXTING YOU CLIPS SHOT ON AN IPHONE 4S
IV. ANNOUNCERS
Even a lousy game can turn into something enjoyable in the hands of a capable announcing team; they'll tell fun stories, bring drama to the right moments, and make for an overall pleasant listening experience. None of that is an option here.
$1 Gus Johnson and he's going to call it like it's overtime in the national championship
$2 Tommy Tuberville and Lou Holtz
$3 Two announcers who usually work NFL games and don't know anything about college football so they're just going to talk about the tension between Antonio Brown and the Pittsburgh Steelers most of the time. They will also spend 10 minutes talking about Tim Tebow, though.
$4 ABC's NBA crew for some reason? But Mike Breen's sick. You're only getting Jeff Van Gundy and Mark Jackson.
MAMA, THERE GOES THAT MAN
$5 Your uncle Dave, who does not watch college football regularly and still thinks Florida State and Notre Dame are the best teams, and he's gonna spend a lot of the broadcast talking about how Joe Paterno got a raw deal
V. WILD CARD ROUND
Now let's just spice it up with some random modifiers, because if there's one lesson to take away from living in 2019, it's "there's no reason you can't make something that's already bad much worse". To wit:
$1 They just installed new turf and it didn't take and no one can get a good footing
$2 It decides a division title even though both teams are very bad, one of them's going to have to play in a conference championship game that they're obviously going to lose
$3 Six starters from each team were suspended the day before the game for their involvement in an illegal cockfighting ring; we're getting a lot of unprepared backups
$4 The head coaches were both fired hours before gametime and now Greg Schiano and Randy Edsall are serving as interim coaches and the players have not bought in
$5 Ohio State's superfans are there for no reason but they're every bit as excited as normal and they're going to be on camera a lot
Okay, I'm putting it in your hands. Make a terrible game.