Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of rats.
Substantial evidence suggests that poor intrauterine milieu elicited by maternal nutritional disturbance may programme susceptibility in the fetus to later development of chronic diseases, such as obesity, hypertension, cardiovascular disease and diabetes. One of the most interesting features of fetal programming is the evidence from several studies that the consequences may not be limited to the first-generation offspring and that it can be passed transgenerationally. In the present study, female rats (F0) were fed either a normal-protein diet [control diet (C); 19 g of protein/100 g of diet] or a low-protein diet [restricted diet (R); 5 g of protein/100 g of diet]. The offspring were termed according to the period and the types of diet the dams were fed, i.e. CC, RC, CR and RR (first letter indicates the diet during gestation and the second the diet during lactation). At 3 months of age, F1 females were bred to proven males, outside the experiment, to produce F2 offspring. At weaning, F2 offspring were divided by gender. RC1 offspring (with the number indicating the filial generation) were born with low birthweight, but afterwards they had catch-up growth, reaching the weight of the CC1 offspring. The increased glycaemia in RC1 offspring was associated with insulin resistance. CR1 and RR1 offspring had impaired growth with no changes in glucose metabolism. RC2 offspring had high BM (body mass) at birth, which was sustained over the whole experiment in male offspring. The F2 generation had more alteration in glucose metabolism than the F1 generation. CR2 and RC2 offspring had hyperglycaemia accompanied by hyperinsulinaemia and insulin resistance in both genders. CR2 offspring had an increase in body adiposity with hyperleptinaemia. In conclusion, low protein during gestation improves BM, fat mass and growth rate in F1 rats, but has adverse effects on glucose and leptin metabolism, resulting in insulin resistance in adult F1 and F2 offspring. Low protein during lactation has adverse effects on glucose, insulin and leptin metabolism, resulting in insulin resistance in adult F2 offspring. These findings suggest that low protein during gestation and/or lactation can be passed transgenerationally to the second generation.
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551-030 Rio de Janeiro, Brazil.


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Music played in-store can help increase sales and customer retention.
By Mikko Matikka Voice Network Badge Voice Network contributor, an ongoing writer for our guest opinion column.
The spot features moms of Jonah Hill, Serena Williams, Dwayne Johnson and more.
Cause-related marketing needs to balance a fine line.
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On Wednesday I set everything up at around 4:00PM to catch them. The Tomcat was in the trap within an hour. So I covered him up and put him in our carport. I knew that I would be in for a tussle moving the awkwardly long cage, but it is quite frightful to move an 11 pound tomcat as he hisses and pops and thrashes around. I put him on the back carport, kind of terrified that his claws would somehow get through the little grates even though I rationally knew they couldn't.
Within the next 20 minutes I had caught one little kitten on the front porch. He was pretty easy to move back to the carport. It had started to rain though so I moved all of the traps to the carport and out of the rain. I moved the tomcat and kitten inside the house where they could have quiet and not stress. I should mention that I had taken the dogs into the doggie daycare and boarded them overnight because I knew that this could get complicated otherwise. So for one night our dog room turned into a cat room.
I left the trap setup on the carport, and lo and behold by the time I got the first kitten settled another one was already in that trap. When I went to pick up that kitten mom cat gave me a stern hiss from the corner. We only had three traps, so that left us with a decision to move a kitten to a regular carrier or release a kitten to catch mom. Joe and I decided to put the kitten in the carrier, hoping that if we caught mom we would be able to make a fourth appointment at the vets office. After getting the kitten into the carrier with some careful finagling, we reset the trap to catch mom. Mom actually walked right in the trap, I think that she wanted to go where her kitten was. That left us with two adult cats and two kittens hissing in our dog room.
We hadn't seen any sign of the other male cat or the other little male kitten for a couple of days, so we declared that we were done kitty catching for the night.
The smell the next morning was horrendous, and I slept with one eye open still fearful that the tomcat would realize his mission of breaking out of that trap and tearing every living human being to shreds in the house. I'm sure our bird was non-plussed as well with the whole situation.
I moved them all out onto the carport. The TNR hero came and brought another trap so that we could transfer the kitten out of the carrier for the vet. It's much better for them to be in a trap where the vets can have access through the bars. Getting rid of the smell in the house was a task, but thankfully we have tile floors.
It took about an hour at the vet to check them in. They weren't all done at the time they were supposed to be, so two trips were necessary to pick them all up. In the meantime I ran the towels and blankets they used two times through our washer, the tomcat was quite the stinker to say the least.
I brought all of the cats to a friendly ladies house who is gracious enough to let the TNR organization set up the cats in her carport to heal after their surgery. Connecting some traps together to create a suite where they had room for a litter box on one end and food dishes on the other end took about an hour.
The next few days were spent going over and feeding the cats and scooping the litter. I can't express how thankful I am that our local cat hero also went over to feed them so that wasn't as much of a task.
During these few days the question came up about where to shelter the cats. It's best to provide them a shelter so they stay and no other cats move in their place (therefore giving us the same problem next year).
So I called no-kill rescues. I only called two, truthfully. The second one told me that they get 60-70 calls a day from people in my situation. I didn't want to put myself through continual rejection by calling every rescue in town, and frankly I didn't want to bother them because they are doing a tough job and I knew that they couldn't help. I needed another option. In the meantime my husband spotted yet a third kitten, and another male started hanging around the house. I needed my option quickly.
Being the queen of google, I discovered that there was a trap-neuter-return program in my area. I contacted them through facebook and have learned a ton about the process. It's definitely the most responsible thing to do for adult cats. It's not their fault that they are out there and shouldn't be sentenced to certain death by trapping them and sending them to the county animal shelter. It's actually the right thing to do for the kittens if you can not otherwise take them in and socialize them.
What I've learned is that it's a time commitment to TNR (Trap-Neuter-Return). I'm thankful that as a teacher I had a little bit of time. I've learned that there are traps out there that are better than the ones you find at the hardware store that are more humane for the cats, and that there are all sorts of different traps that can be used for different situations.
So after speaking with our local TNR leader, she came over to the house to drop off the traps. She had made appointments for three cats that Thursday, which gave me 3 days for the cats to get used to the trap before I used it on the last night.
Setting everything up wasn't too hard, and they used them pretty much right away. Luckily they were all used to coming up to the porch and eating anyhow and didn't seem too concerned about going in the trap.
When I saw a little cat hanging around the house last month something prompted me to go and get a bag of food and welcome it to my porch. Although I am very much a "dog" person, the idea of having a cat come by to share a morning cup of coffee seemed somehow calming and ideal. I was about two weeks into feeding her in the morning and evening, getting her to eat from my hand and stay a little bit, when one morning something unexpected happened.
Yes, two of the tiniest cutest little faces on the planet came around the corner with her. I immediately knew that I was in for a challenge. They couldn't come in and be inside kitties because three dogs, a bird, and two feral kittens would be too much for me. I couldn't bear take them to a county shelter to face their death due to overcrowding. I definitely couldn't become the block cat lady where these cats would breed and create 50 cats before I knew it.
Every time I come back to do my weekly gratitude challenge is an opportunity to evaluate the week and delve into some optimism for next week. Today is not only week 2 of gratitude, it is also Fathers day.
I am thankful for my father and the upbringing he and my mother provided me. My dad has always been there for me and supported me in the things I want to do.
When I think about my dad I think about watching football with him from the day I was born, being woken up at 4am to go fishing out on the lake every Summer, traveling for the family business with him, and always having projects to work on. Now as an adult I think of how hard he worked to run a business, spending countless hours doing whatever needed to be done at all times of day and night to make it. He never complains about work, whatever that work might be.
So my gratitude starts this week off for my Father, who is the best dad a girl could have.
Last December my husband and I were in Chicago for a conference. This happens to be the place that the Bellicon company has a showroom for their exercise trampolines. Of course I insisted on visiting or a test bounce.
Naturally I ordered one. I got the mid-sized one which fits nicely in our living room. I do love it. If you want to feel like a kid again, bounce on one for a little bit. You can't help but smile a little.
It is definitely a good workout if you use is correctly and consistently. That is my newest thing to add to my Summer schedule. If I'm going to get my life on track I'll need to shed more than 10 years of kitsch and clutter.
I have kept a written journal on and off ever since I can remember. It's usually something that I start using when times are tough, but more recently I have been using it also as my planner. Anyone who journals knows the therapeutic benefit of writing down those things that need to stay just between you and the page.
I want to venture out and give myself the challenge of expressing my gratitude here once a week. Like most people I have had a life with a whole lot of ups and downs, but remembering to be grateful should always be a part of experiencing the good and the not-so-good.
So this week I am grateful that I have the opportunity to simplify and recharge this summer. I have two months where I'll have an extremely flexible schedule with still enough work and projects to complete to keep me creatively engaged. Having the time to actually get into some better habits, it's almost like a complete reset. I'm thankful for that, and I know that not everyone is in the position to be able to slow down things enough to re-evaluate what is necessary in life and what is not.
Most of this week has focused on cleaning out and simplifying my possessions. My husband and I took four carloads of donations to area charities. I am sure that there will be a good need for some of the things we donated in our community. Also, by clearing these things from our house there is a noticeable difference in the stress level in the house. It is just more relaxing without extra stuff. I'm thankful to have this time to do this.
Joe and I headed out this morning to our local farmer's market. It has been great to see the market expand from a few booths when we first moved to pensacola to the size that it is now. I picked up a jar of local gallberry honey as the one we had bought in December is finally almost gone. The crowd was pretty big today, so we didn't stay that long.
I also whittled down some more of our clutter that is hanging around. I'm down to consolidating and making choices about giving away things that I actually still like. I am striving for only having those things that are essential to my happiness. Letting some things go will be an important step into doing that. So on the chopping block this week might be our record player and records, an xbox, and some neat decorative items that either don't fit our decor anymore, or I just can't find the right spot for.
I had other great plans for today, but mostly that was what was actually done.
I once had a student tell me out of the blue that I had an old soul. I thought that was the nicest and truest thing that could be said of me. Maybe that's why I chose to be a musician in the first place. I have a career where I can choose to go back in time whenever I wish. Making music from the past is having some sort of authentic connection to that past.
Music is rather like time travel, isn't it? Just listening to it is like you going on a journey just for a bit, riding along and hearing stories and emotions or getting impressions from the time period or an experience. Your tour guide tells you a bit as time is filled with a melody which gives a picture of something in sound for a minute or ten. Maybe more. Sure he can't tell you everything, but you get a good idea as you travel on through the song.


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Cavan H. Jun 28 .
Pretty good, whalewatching and Morro Bay harbor touring (with underwater windows) made even better by Cvan. Now there's a captain for you. If he's working that's who you want to go with.
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Sister Rosetta Tharpe: The Godmother of Rock and Roll
Three questions about desegregation for Sarah Garland, author of Divided We Fail
Historical Beacon Buzz: Langston Hughes reviews James Baldwin
Fifty-Five Years Ago Today...
Notes of a Native Son by James Baldwin
Yes, this publicity hit is from February 26, 1958, but we didn't have a blog (much less the not-to-be-missed Beacon Buzz report) back then ... The New York Times published this review of James Baldwin's Notes of a Native Son, written by Langston Hughes.
James Baldwin writes down to nobody, and he is trying very hard to write up to himself. As an essayist he is thought-provoking, tantalizing, irritating, abusing and amusing. And he uses words as the sea uses waves, to flow and beat, advance and retreat, rise and take a bow in disappearing.
Read Edward P. Jones' introduction to our new edition of Notes of a Native Son on Scribd.
You can get a copy of our new edition of Notes of a Native Son (or any other African American Studies title) for 20% off and free shipping if you order with code FEB2013. Check out the details of our Black History Month Sale at Beacon.org.
Recent Notable Mentions
Into Great Silence: A Memoir of Discovery and Loss among Vanishing Orcas by Eva Saulitis
OnEarth magazine's profile of Eva Saulitis, titled, "The Woman Who Loves Orcas" made the cover of their Spring 13 issue.
She had heard killer whales before, but this was "something other." Communicating across great distances, they would caterwaul in long, siren-like cries, turned up at the end as if they were questions. "This was a voice at once strident and mournful," she writes in her memoir, "a strange hybrid instrument, part trumpet, part oboe, part elephant, part foghorn. And loud." But when the lone scouts were joined by more members of their group, the calls changed to "upswept squawks punctuated by silence; bangs and cracks, like axe blows against one-by planks, some we could attribute to fluke slaps, and some not. Now and then a syncopated blast of echolocation, like automatic gunfire." [Read More]
Faitheist: How an Atheist Found Common Ground with the Religious by Chris Stedman
Q&A with Chris Stedman on BuzzFeed.
Divided we Fail: The Story of an African American Community that Ended the Era of School Desegregation by Sarah Garland
C-SPAN/Book TV aired their "After Words" episode with Sarah Garland interviewed by Marc Lamont.
Fast Future: How the Millennial Generation Is Shaping Our World by David D. Burstein
Write-up of Burstein's Politics and Prose event.
"Sick of getting a bum rap? Millenials fight back." David Burstein on MSNBC's The Cycle.
Interview on The Diane Rehm Show in a panel discussion titled "What It Means to be a Millennial."
Excerpt, "Millenials Will Save Us," on Salon.com.
"A Very Fast Future," online at Forbes:
"FAST FUTURE is a fantastic read for anyone who is curious about the mindset and perspective that the Millennial generation is bringing to their businesses, their politics, and their personal lives. Millennials will continue to shape that world as their ranks elevate to higher levels in corporations and governments and, if FAST FUTURE is any indication, they'll not be shy about letting you know that they've arrived." [Read More]
Shout, Sister, Shout!: The Untold Story of Rock-and-Roll Trailblazer Sister Rosetta Tharpe by Gayle Wald
Watch author Gayle Wald and be amazed by the extraordinary guitar playing of "Sister Rosetta Tharpe, the Godmother of Rock & Roll" on the PBS American Masters website.
Excerpt from Shout, Sister, Shout! featured on Scribd's homepage in their "Best of the Day" section.
Enter to win a copy of Shout, Sister, Shout! on Beacon.org
"In a Single Garment of Destiny": A Global Vision of Justice by Martin Luther King, Jr.
An excerpt, "Racism and the World House" is now online at Yes! Magazine.
Soul Repair: Recovering from Moral Injury after War by Rita Nakashima Brock and Gabriella Lettini
Featured in a Chicago Tribune column by Robert Koehler:
This remarkable book, published in 2012, takes a long, hard look at the dehumanizing effects of war, through the experiences of a number of vets from various wars (Vietnam, Iraq, Afghanistan) who share their suffering -- and bare their souls -- to the authors.
"Soul Repair" is an assault on the mythology and public relations of war, on the default setting of nationhood, that: "We sleep comfortably in our beds at night because violent men do violence on our behalf." No matter how many lies are at the foundation of a given war, no matter how disastrously unnecessary and destructive it turns out to be in retrospect -- oops -- the myth of war is ever-unsullied: This time the danger is really there. This time it's crucial that we carpet bomb civilians, then send in our boys and girls to clean out the enemy insurgents. This time it's really for democracy and the American Dream and a good night's sleep.
Fist Stick Knife Gun: A Personal History of Violence by Geoffrey Canada
On the Freakonomics podcast, Steve Levitt calls Fist Stick Knife Gun: "one of the best books I've ever read in my life. I urge people to go and find it. It's fantastically insightful."
Dirt Work: An Education in the Woods by Christine Byl
Library Journal review: "This is no Walden: each chapter begins with a meditation on a tool, including an axe, rock bar, chainsaw, and skid steer... Byl's writing is superb and doesn't romanticize her dirty work."
What Doctors Feel: How Emotions Affect the Practice of Medicine by Danielle Ofri
"Here is a book that is at once sad and joyful, frightening and thought-provoking. In her lucid and passionate explanations of the important role that emotions play in the practice of medicine and in healing and health, Danielle Ofri tells stories of great importance to both doctors and patients." Perri Klass, author of Treatment Kind and Fair: Letters to a Young Doctor
Black History Month: Select books 20% off, plus free gift with purchase
Beacon Books at Audible: Outlaw Marriages by Rodger Streitmatter
Beacon Buzz: Gather at the Table, Faitheist, and more!
Celebrating Black History Month Three Right Ways
Beacon Buzz: Prairie Silence, women in the military, and more!
Posted at 01:00 PM in Beacon Press News, Faitheist, Fast Future, In a Single Garment of Destiny, Into Great Silence, Notes of a Native Son, Shout Sister Shout | Permalink | Comments (0)

redpajama_set_name: RedPajamaCommonCrawl


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The British Newspaper Archive Reaches 8 Million Online Pages
by Lisa Cooke | May 25, 2014 | 01 What's New, British, Findmypast, Newspaper
The British Newspaper Archive has reached a new major milestone: 8 million newspaper pages now online! The counter on the homepage ticked over that amount while adding editions of the Sheffield Daily Telegraph, Cheshire Observer and The Yorkshire Post and Leeds Intelligencer.
If you've tried searching for a person, event or place before without success, it's well worth trying again now–and you can try a search for FREE. The amount online has doubled since the website launched with 4 million pages in November 2011. The time period covered now stretches from 1710 – 1954 too, much broader than at launch.
Looking for something that's not there yet?
Thousands of pages are added every week, so your chance of finding something amazing increases all the time. 825,000 new pages have already been added so far this year. See a list of the newspaper titles that have been added or updated in the last 30 days here.
The British Newspaper Archive is a partnership project between the British Library and DC Thomson Family History (formerly known as brightsolid online publishing, mother company of the FindMyPast family of genealogy websites). From November 2011 to 2021, up to 40 million pages from historical newspapers across the UK and Ireland will be uploaded to the website.
Learn more about finding your relatives in the paper in my book, How to Find Your Family History in Newspapers. It's available as an e-book or in print. Read all about it here!


jardin-perdu / Summer dreams; it's time to plant summer flowering bulbs.
Summer dreams; it's time to plant summer flowering bulbs.
It's the first of March, spring officially starts just 19 more days from now, and still in France the snow persists. This morning however, as I walked around the garden with Tipsy, one of our cats, I felt optimistic for the first time that perhaps, at last, winter was on its way out.
Although parts of the garden are still covered by a layer of snow, it is melting, the day is warmer, grass is appearing, and hopefully this time the green will stay.
Through the melted patches of snow, having survived for 8 weeks under an almost constant blanket of white, tulips, snowdrops and Hemerocallis are fighting through and sending up their first shoots. Yes I believe it is time to be optimistic and hope that before long we'll soon all be up to our elbows in dirt, digging up, dividing and moving our plants.
Crocosmia Lucifer – a big, bold, bright red variety which grows to 1m tall.
Crocosmia 'Emily Mckenzie' a smaller, more delicate variety which has orange petals stained crimson at the centre.
Dahlia Cactus 'Chat Noir' a double dahlia, rich garnet red in colour with an almost black centre.
Dahlia Cactus 'Clair de lune' a creamy yellow dahlia.
Dahlia Balle 'Evelyne' a lovely creamy white dahlia which is tinged with mauve.
Lilium 'Landini.' French name: Lis asiatique 'Landini.' Asiatic lilies are dependable perennials. This one is a gorgeous dark, rich, crimson red.
Lily regale 'Album.' French name: Lis trompette 'Régale'. This lily has large, pure white flowers and bright orange anthers and is highly scented.
Gladioli 'Purple Flora.' French name: Glaïeuls à grandes fleurs 'Purple flora.' This is a glorious velvet purple gladioli.
Gladioli 'Green Star.' French name: Glaïeuls 'Green Star.' This is an acid green gladioli which doesn't fade to yellow.
Canna Liberty. French name: Canna à feuillage pourpre 'Liberté.' The glorious orange flowers of this Canna look stunning against the purple foliage.
Get dreaming of the long, hot French summers and planning your equally hot, dramatic borders. All these bulbs can be bought here in France from Plantes et Jardins, click on the link either in the footer or side bar to take you to their website.
If you have a favourite summer flowering bulb or a specific type of Dahlia or Gladioli which you think is a real winner, I'd love to hear about it, so please leave your comments in the box below.


These two NitWits would face Less Time had they been drug smugglers. Next time they might take the WIDE-OPEN Mexican Border route!!
After hearing this tune I ran for the Toilet!But Whatever floats your,er,um,,BOAT!!!
We should have the Japanese defence forces escorting the ship-Not Any other ! Shoot to Kill-the only way to stop this!


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Q: 13.10 qtcreateor 271 wont work Just installed ubuntu 13.10 x86 with all updates. I then installed qt4 libraries and qt creator 271:
sudo apt-get install build-essentials
sudo apt-get install libqt4-dev
sudi apt-get install qtcreator

Both installed successfully, and i can launch qt creator, but then i get a black window when i switch to "examples" or "development":
http://i.imgur.com/koi6S9S.png
The windows cannot be closed.
I am guessing  because qtcreator somehow cannot find the qt version i installed. This is the settings page:
http://i.imgur.com/OgAKH7S.png
what to do?

A: Yeah, you're not the first with this problem. I asked this question before in askubuntu and in stackoverflow. I even filled a report it on launchpad.
I did much research about it but I didn't find any solution for that. Now I am using the offical qtcreator from qt-project.org. The advantage is that examples and tutorials are available and you have the latetst documentation installed which is one of the best resources to learn everything about Qt-Programming. And, of course, you have the latest version of Qt. The only problem with this is that the offical version lacks nice Ubuntu integration, but this is really acceptable.

redpajama_set_name: RedPajamaStackExchange


text:
Hot Stories You Missed Today, August 16th, On HollyBaby!
August 16, 2011 8:30PM EDT
Sean Kingston Talks About His Feud With Selena Gomez: I'm Better Friends With Justin Bieber!
Has Selena Gomez come between Justin Bieber and his BFF, Sean Kingston? The Jamaican-American singer explained what really happened to Ryan Seacrest Aug. 16!
Girlfriends can be a tricky subject when it comes to bromances, and the Selena Gomez, Justin Bieber and Sean Kingston triangle is no different! Rumors have been swirling that Sean, 21, isn't a big Selena fan since she's become his pal Justin's main focus. However, he says that's not the case…he's just not as close to her as he is Justin!
"The first thing I will say, no offense to Selena, but I knew Justin before. He came to me a was like 'Yo, what do you think about the relationship.' So, I'm like a big bro mentor to him," Sean told Ryan Seacrest on his 102.7 KIIS-FM radio show Aug. 16.
The "Eenie Meenie" singer continued, "The media takes things and they roll with it. I was just with Selena they other day at the Teen Choice Awards, we hung out, it was cool, it was all love."
Justin and Sean have been working together on music and touring for years, so it's easy to understand why Sean might feel a little replaced by Selena, who has been taking up all of Justin's spare time since they began dating late last year. However, it's good to know there are no harsh feelings between Justin's two BFFs.
Have you ever gotten into a fight with your significant other's BFF? Sound off below!
Justin Bieber Sean Kingston Selena Gomez


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Luís dos Reis Falcão (Florianópolis, bairro da Trindade,  — Rio Grande do Sul, ) foi um militar e político brasileiro.

Filho de Anacleto dos Reis Coutinho e de Luísa Pureza Falcão. Casou com Felicidade Bandeira Falcão.

Foi um dos membros da Junta governativa catarinense de 1891. Foi reformado em 1893 como general-de-brigada.

Governadores de Santa Catarina
Naturais de Florianópolis

redpajama_set_name: RedPajamaWikipedia


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Q: How did the Universe behave just at the end of inflation? Edit When the inflaton field $\phi$ rolls down the potential $V(\phi)$ to the value $\phi=\phi_f$ where the slow-roll parameter $\epsilon(\phi_f)\to 1$, inflation ends. By calculating the behaviour of the scale factor at this time, how the Universe was radiation-dominated? How does the exponential scale factor $a(t)\sim e^{Ht}$ goes to the power law $a(t)\sim t^{1/2}$?

A: Let me denote the inflation field energy density w.r.t to the critical density as $\Omega_{\rm f}$.
We can write the Hubble function as
$$H(z) = H_0\sqrt{\Omega_{\rm m,0}(1+z)^3 + \Omega_{\rm r,0} (1+z)^4 + \Omega_{\Lambda} + \Omega_{f}(z)}$$
Before the inflation, the universe was radiation dominated. This implies that
$$H(z) \approx H_0\sqrt{\Omega_{r,0}(1+z)^{4}}$$
During the inflation, what happens is that the $\Omega_{f}(z)$ starts to become important and starts to dominate the energy density of the universe so during the inflation period we obtain
$$H(z) \approx H_0\sqrt{\Omega_{f}(z)}$$
When the inflation fields start to oscillate the $\Omega_{\rm f}(z)$ starts to decrease and after some period it vanishes.
So we are back to the phase where
$$H(z) \approx H_0\sqrt{\Omega_{r,0}(1+z)^{4}}$$
The inflation field does not affect the universe in any other way. It is just a field that increases the energy density of the field and accelerates the expansion of the universe. There's no need for fancy equations to understand the process.
Without the inflation field, the universe was in already radiation dominated phase. The inflation field just accelerates the expansion of the universe briefly and vanishes. The inflation field is like a cosmological constant but just happens momentarily in the early universe.


Gas cylinders can pose serious threats if they are not stored properly. Flammable and toxic substances must be stored in suitable storage solutions in order to comply with regulations set out in the workplace.
HSE, also known as Health Safety Executive, provides a technical measures document that covers handling and storage guidelines of such substances in drums and cylinders. It refers to relevant codes of practice and standards for those who are required to be familiar with it.
Workplaces should also comply with BCGA (British Compressed Gases Association) and their code of practice in regards to gas cylinders and storage.
What Is A Gas Cylinder?
This might be an obvious question, but many are unable to form a correct answer! Ultimately, a gas cylinder is a pressure vessel for storing gases under high pressures. The gas cylinders are usually made of carbon steel, stainless steel, aluminium or composite bottles.
Gas cylinder cages and storage cabinets offer a versatile and durable solution in ensuring the safe handling of gas cylinders. There are many different types of gas cylinder cages, stands and cabinets which means choosing the right storage solution depends on what type of workforce you have and the setting you are in.
Fire rated gas cylinder cabinets – Fire resistant gas cylinder cabinets should be certified to EN 14470-1/2 standard and they are available with a 30-minute fire rating or 90-minute fire rating. These types of fire rated gas cylinder cabinets are used for inside buildings and to increase the safety of the workplace. With mounting rails, cylinder holders and tension straps, it makes gas cylinder storage even more secure.
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The purpose of this document is to provide information to the Shockwave developer community about changes made to new versions of Adobe Shockwave Player, whether those changes involve modifications to the Shockwave Player itself or to the Shockwave installer. A brief summary of these changes is included for each version. Links are provided to other documents that list the changes in further detail.
Note: This document is intended to help developers keep current with changes to Shockwave Player and is not designed to document the entire history of Shockwave. Consequently, it starts with the last major version of Shockwave Player (Shockwave Player 8.0) that was released as of the date this TechNote was first written.
Change Notes: Update release of the Shockwave Player that includes changes to the installer only. For more information see "Bug fixes for Shockwave versions 10.2.x". (TechNote kb402316).
Change Notes: Update release of the Shockwave Player that includes fixes for Keyboard issues and update from 8.5 issues. For more information see "Bug fixes for Shockwave versions 10.2.x" (TechNote kb402316).
Change Notes: Update release of the Shockwave Player that includes Windows Vista (32-bit) compatibility and installation, additional 3D rendering options, registration at Shockwave.com appears after installation instead of during, and fixes a number of restart after install issues. "Bug fixes for Shockwave versions 10.2.x" (TechNote kb402316).
Change Notes: This is an update release of the Shockwave Player that includes fixes for the auto update issues. With 10.1.4.020, users would be offered to upgrade from Shockwave 8.x or higher. It may be noted that no feature has been removed and no function is deprecated in this release.
Change Notes: This is an update release of the Shockwave Player that includes fixes for some known issues as well as a new Flash Asset Xtra. For more information see "Bug fixes for Director and Shockwave versions 10.x.x" (TechNote 19353).
Change Notes: This is an update release of the Shockwave Player that includes fixes for a number of issues found since the release of version 10.1.
Change Notes: This is an update release of the Shockwave Player that includes fixes for a number of issues found since the initial release of version 10. In addition to those bug fixes this update also includes changes to the installation process on Windows that include offering the user the Yahoo! Companion Toolbar.
Change Notes: Update to theFlash Asset and NetLingo Xtras, including these fixes: browser freezing, Flash sound control, eliminate a 4 byte memory leak, fixes for several Japanese text issues, netDone() Function returning False and a "URL not found" error resolution.
Change Notes: Updated player for Macintosh OS X. New Xtras include Speech and Flash Asset Xtras. QuickTime support has been updated to QuickTime 6 using the QT6 Asset Xtra.
Change Notes: New Xtras include Speech and Flash Asset Xtras. QuickTime support has been updated to QuickTime 6 using the QT6 Asset Xtra.
Change Notes: Updates to the The NetFile and NetLingo xtras. Resolving issues preventing access of local files stored safely within dswMedia folders from being accessed by movies playing in the browser. Resolving issue with the netDone() and netStatus() methods to falsely indicate that successfully completed downloads were still in progress. Updated Xtras are for Windows and Macintosh OS9.x only.
Change Notes: Includes fixes that address security issues related to the Flash Asset Xtra as well as to Net Lingo. In addition the update includes changes to the types of Shockwave installers being delivered. Those downloading the installer while using Internet Explorer on Windows will continue to receive the ultra-shim installer whereas all other users will now receive a full, stand-alone installer.
Change Notes: Includes a fix for openGL causing a system freeze on Macintosh Titanium, iBooks and some desktop computers.
Change Notes: Support for Windows XP and Macintosh OS X. New anti-aliasing feature. Bug fixes.
Change Notes: A few bug fixes have been made to the sound feature and these fixes are being released in an updated Sound Control Xtra. The details on these fixes will become available shortly and will be linked to from this document. Additionally, the auto-update process has been activated for all users with Shockwave player versions of 8.0 and prior.
Change Notes: Installer-only change. The installer was revised to comply with the Children's Online Privacy Protection Act (COPPA). This Act restricts companies from collecting personal information from children under 13. Other aesthetic changes were made to the download experience as well.
Change Notes: This is the initial Shockwave Player 8.5, which incorporates great new functionality including interactive 3D, support for Real Media streaming and Flash 5 and Multi-user Server enhancements (UDP messaging and server-side scripting).
Change Notes: Installer-only change. Updated Flash control and Flash Plug-in has been folded into the installer. Additionally, a minor change to the installer has been made to help track where referrals to the download page are coming from.
Change Notes: Installer-only change. The installer was revised to comply with the Children's Online Privacy Protection Act (COPPA). This Act restricts companies from collecting personal information from children under 13.
Change Notes: This new version involves a Shockwave Player update.
Change Notes: This is the initial Shockwave Player 8.0.
For more information on Shockwave Player, see the Shockwave Player page on the Adobe website.


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When Ryanair is more trustworthy than the Scottish Government
by Brian Monteith
article from Thursday 1, March, 2018
IT SAYS EVERYTHING about our Scottish Government that Ryanair – that most outspoken, avaricious and horrendous model for customer relations – is to be believed before the democratic manifestation of the people.
This week Ryanair announced that it was closing its Glasgow base from November this year; shifting its one aircraft located there to Edinburgh along with five routes to Londonderry, Lisbon, Sofia, Riga and Berlin. Together with six newly announced routes from Edinburgh (Gothenburg, Hamburg, Memmingen, Stockholm, Seville & Tallinn) some 700 new jobs will be created there. Glasgow will retain only three routes of its twenty-three routes (Dublin, Krakow and Wroclaw) with five going to Edinburgh and the rest closing – putting three-hundred jobs put at risk.
Ryanair give as its primary reason that it had been promised in advance of opening its Glasgow base in 2014 that the Scottish Government would abolish Air Passenger Duty and that this promise had been broken. Ryanair argued it had held on when the Scottish Government shifted its position to halve the APD to 50% on short haul flights but that with what it called a "softening" in demand due to the temporary uncertainty over Brexit it could no longer wait on a promise that showed no signs of being delivered.
The Scottish Government's response was to blame Brexit.
Since its inception Ryanair won itself lots of friends and customers because of its exceedingly cheap air fares and large network to destinations previously unreachable directly. This was, however, despite its brash and sparse passenger cabins, its belief in charging additionally for everything it deemed to be an extra or for minor booking errors. Its manner in dealing with customer complaints lost it further sympathy, to the point that people started using Ryanair as a last resort – where there were no other operators or other competitors were just too expensive.
Eventually Ryanair worked out that its attitude was actually costing it business and about three years ago it started to introduce changes in pricing and customer service that made it a much more enjoyable airline to use. I use flights regularly for business between London, Edinburgh, Belfast, Birmingham, Londonderry, Toulouse, Carcassonne, Rodez, Paris, Brussels, Barcelona and more – and personally I found EasyJet had become (and remains) the airline to avoid, it is dearer, less punctual, with more surly staff and let me say again – less punctual.
I think I have a good understanding of the Ryanair business model, I've seen how the airline opens and closes routes and changes operations, even when they might appear busy – the airline clear looks to the bottom line and will only take a hit on a route for so long. And why not, it's a business, not a charity, or worse a government department that bleeds the taxpayer dry.
So when Ryanair says it is closing its Glasgow base I give some consideration to its reasoning and while there is bound to be some smoke laid for cover I happen to believe that truth is on their side. Here's five reasons why.
1) APD is a regressive flat tax of £13 per short haul flight, it makes shorter cheaper flights proportionately more expensive. A flight that costs, say, £20 on the ticket is actually benefitting the airline by only £7 – from which any profit must be marginal and therefore requires large numbers to justify the route – while the government will receive £13 merely just for existing. APD discourages the use of short haul flights against other modes (such as railways) or from travelling at all. Consequently abolishing or cutting APD would lead to a lift in passenger numbers, which would have justified the expansion of a services out of Glasgow.
2) When Ryanair opened its base in 2014 it would have been after a significant period of building and then reviewing a detailed business case. It is clear from the Scottish Government's policy at the time of abolishing APD – that Ryanair anticipated the expected lift in passenger traffic would by sufficient to make it worthwhile establishing a base in Glasgow, as well as maintaining the current one in Edinburgh. The failure of the Scottish Government to deliver its first promise to abolish APD and even its second promise to halve APD would eventually have to be faced up to by Ryanair. The day of reckoning has arrived and routes are being cut, jobs lost and the Glasgow base transferred to Edinburgh.
3) Ryanair's argument that Edinburgh is a more attractive departure point from Scotland is true. Passengers comment that they find the "experience" of travelling from Glasgow compared with Edinburgh more pleasant, but this is currently no surprise as Edinburgh has become a victim of it own success and is overcrowded as a result (2017 passenger numbers rose to 13.43 million against Glasgow's 9.9 million). Once Edinburgh's new Terminal extension opens next year the attitude of passengers – with more space and additional amenities – is likely to alter.
The experience aside, thanks to Scotland's dislocated transport network – with motorways that don't link properly and the lack of helpful rail connections –Edinburgh Airport is easier to get to than Glasgow for most Scots. The truth is that Glasgow Airport is on the wrong side of Glasgow – it serves Ayrshire, South and West Glasgow well. For the rest of Scotland, and at rush hour or during special events in Glasgow, even for passengers from Eastern Glasgow and most of Lanarkshire Edinburgh can be easier to reach.
3) Ryanair's argument that Edinburgh is a more attractive destination (even as a way to reach Glasgow) is also true. All the tourism figures demonstrate this; anything else is just wishful thinking or blind prejudice. This makes locating more routes to and from Edinburgh more attractive to Ryanair.
4) The combination of Edinburgh's attractiveness as a departure and arrival point makes Ryanair's routes more profitable as it can charge higher fares. The distance between Edinburgh Airport and Glasgow city Centre by bus is relatively short (and certainly so by Ryanair standards for airport distances to cities) so it makes sense for Ryanair to fly in and out of Edinburgh and let passengers make there way to and from Edinburgh Airport.
5) "Despite Brexit" is a cliché used by everyone to cover a multitude of problems – soft or falling tourism figures should not be one of them. Visits to Scotland have consistently risen since the EU referendum vote and passenger number in Glasgow and Edinburgh have both benefitted.
Tourism to Scotland rose 2 per cent overall in 2017 to 14.1 million visitors, with overseas arrivals up 14 per cent and – belying the negativity of any Brexit effect – a 1.8 million increase in European visitors. Brexit cannot be justified by the Scottish Government as the cause and is only being mentioned by Ryanair as it fits with its corporate stance of being against Brexit – but it could not blame Brexit directly as passenger numbers have climbed. The truth must therefore be elsewhere. Ryanair would have reckoned on a year-on-year increase in passenger numbers from Glasgow but it is the lack of additional numbers following a cut in APD that has not materialised and thus led to Glasgow's base and routes being cut.
Ryanair appears to be in the right; the SNP Scottish Government is desperately scrambling for excuses and blaming Brexit – which is a proxy for blaming Westminster – its usual grievance-driven position.
Oh, and if anyone doubts my political motives in accepting Ryanair's reasoning, then nobody can doubt the motives of Glasgow Airport, which in its statement regarding the decision said, "This is the second example in as many months of an airline cutting capacity in Scotland because of the lack of movement on ADT. The reality is this capacity will be reallocated elsewhere in Europe to countries with more favourable aviation taxation policies to Scotland's detriment."
When the Scottish Government's position is less believable than Ryanair's you know it is in real trouble.
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Davido Biography: Net Worth, Wife, Age, Siblings and more
Davido Biography
David Adedeji Adeleke, better known by his stage name Davido, is a Nigerian singer, songwriter, and record producer. He is 29 years old. Davido has become one of the most successful musical performers on the African continent.
Although Davido spent his formative years in Lagos, Nigeria, he was born in Atlanta, Georgia, in the United States of America (USA) on November 21, 1992. However, he spent most of his life there.
After the release of "Dami Duro" in 2011, he gained widespread attention.On the 21st of November 1992, Davido Adeleke was welcomed into the world by his parents, Mr. Adedeji Adeleke and Mrs. Veronica Imade Adeleke. He is the youngest and youngest kid of The Adedeji Adeleke Family and was born in Atlanta, Georgia. He is also the final child of the family. He has five older siblings.
Davido had the ambition to become a music producer when he was first starting out in the industry. He attended Oakwood University and purchased music equipment that he utilized to create beats.
He was also skilled in the art of music marketing and was intent on advancing the career of one of his cousins who was active in the music industry. On the other hand, things did not go as planned with his cousin.
Educational History
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Because of the affluence of his parents, Davido was able to acquire the very best education available. The British International School was where he spent his elementary and high school years getting his education.
After completing two years of coursework in Business Management at Oakwood University in Alabama, he decided to leave school to concentrate solely on his profession as a musician.
After some time had passed, he made the decision to take his father's recommendation to heart and resume his academic pursuits.
He began his studies for a degree in music at Babcock University in 2011, and he received that degree in 2015. His father had provided funding to the institution so that it could establish a music program and accept its first student.
After spending some time at the British International School in Lagos, Davido relocated to Alabama when he was 16 years old.
Davido began his academic career at Oakwood University in Huntsville, Alabama, majoring in Business Administration. However, he eventually decided to pursue a career in music production instead.
Davido returned to school in 2016 to pursue a degree in Music at Babcock University, from which he ultimately emerged with a bachelor's degree in the subject.
After a period of time, images emerged online showing Davido participating in the National Youth Service Corps.
Back When, the official title of Davido's debut song, was released on the seventh of May, 2011. Rapper Naeto C contributed his vocals to the track, which had a significant role in the song's commercial success.
The track, which was produced by Davido and recorded in London, was filmed in Nigeria by Clarence Peters, who was also the director of the music video. During this time, he was given a recording contract with HKN Records, which is owned by his older brother, Adewale Adeleke.
Omo Baba Olowo was Davido's first studio album, and it was published in 2011. The album had several successful songs, including Dami Duro, Ekuro, Overseas, and Back When. Davido collaborated with a diverse group of outstanding musicians and producers on this album, which was a commercial success.
These musicians and producers included Maleek Berry, Spellz, Shina Rambo, 2baba, Jay Sleek, GospelOnDeBeatz, Naeto C, B-Red, Kayswitch, and Shizzi. The album was not only honored with a nomination for Album of the Year at The Headies 2013, but it also took home the award for Best R&B/Pop Album at the same ceremony.
In 2013, Davido and Shizzi, a friend of Davido's who is also a producer, collaborated to create three successful singles: Gobe, One of a Kind, and Skelewu. Skelewu was a huge success all over the world since it popularized an original dancing style that remained fashionable for a number of years.
Davido filmed not one but two music videos to accompany the tune. The first film was helmed by Sesan, while Moe Musa was behind the camera for the second film that was shot in London.
Davido's single "Aye" was released on the first of February in 2014, and it immediately caused a stir in the business. Six days later, Clarence Peters's music video, which he had directed and filmed, was made available online.
During the same year, he worked along with the South African recording artist Mafikizolo to produce and release the single Tchelete (Good Life). Then, in June of 2015, he released Fans Mi's trap song, which included American rapper Meek Mill as a guest artiste. Fans Mi's song was a collaboration with Meek Mill.
Key Take Away
Full Name: David Adedeji Adeleke
Stage Name: Davido
Born: 21 November 1992 (age 29 years old)
Place of Birth: Atlanta, Georgia, United States
State Of Origin: Osun State
Parents: Adedeji Adeleke, Veronica Adeleke
Children: Hailey Veronica Adeleke, David Adedeji Adeleke Jr., Aurora Imade Adeleke
Siblings: Sharon Adeleke, Adewale Adeleke
Girlfriend • Wife: Chioma Avril Rowland
Occupation: Singer • Songwriter
In January of 2016, Davido shared with his audience the news that he has inked a recording contract with Sony Music, specifically with their music subsidiary RCA Records. After a few months, he established his own record label called Davido Music Worldwide (DMW). During that year, he became Mayorkun, Dremo, and Ichaba's record label executive.
In addition, in 2016, he issued the EP titled Son Of Mercy, which had five tracks. Singles such as "Coolest Kid in Africa," which includes Nasty C, "How Long," and "Gbagbe Oshi" are included on this project.
After another four months, on June 2, 2017, Davido finally released his international smash hit titled "Fall." The song, which was one of the top 100 singles that were searched for on Shazam in the United States, was also certified platinum by the Recording Industry of South Africa (RISA).
Additionally, it was the Nigerian pop song that charted the longest in the history of Billboard. Daps filmed and directed the music video for Fall in the United States. The song is titled "Fall." Since it was uploaded on YouTube, the music video has racked up more than 100 million views, making it the first video ever produced by a Nigerian artist to reach such a significant milestone.
On the 10th of November 2017, only a few days away from his twenty-fifth birthday, he released the song titled "FIA." Clarence Peters was in charge of the music video for the song, which Fresh VDM was responsible for producing.
To commemorate the fact that his girlfriend, Chioma Avril Rowland, turned 23 on April 30th, 2018, he presented the world with his new single, Assurance. At the 2017 MTV Europe Music Awards, Davido was given the prize for Best African Act, which he took home with him. Additionally, he took home the award for Best International Act at this year's BET Awards.
In 2019, Davido's arranged event at The O2 Arena in London was a complete success and sold out. He was the first African solo musician to accomplish this feat. He released two top-charting singles, "Blow My Mind" and "Risky," before to the release of his second studio album, which was titled "A Good Time" and was released on November 22, 2019.
On the former song, he worked along with Chris Brown, while on the latter, he featured Popcaan, a dancehall performer. Meji Alabi was the one behind the camera for the music video for Risky.
The release of his third studio album, titled A Better Time, came on November 13, 2020, much to the delight of his devoted following. This song has guest appearances from a variety of singers, including Ckay, Mayorkun, Bella Shmurda, Lil Baby, Nas, Nicki Minaj, Young Thug, and Chris Brown, among others.
By December of the next year (2020), the album had been streamed over 213.2 million times. He had already published the song "Fem" on the 10th of September 2020, before the project was made available for purchase. Dammy Twitch was the one in charge of directing the song video.
Davido was born in the city of Atlanta in the state of Georgia. His father, Adedeji Adeleke, is a business magnate, and his mother, Veronica Adeleke, is a college professor. Adeleke was born into a family of educators.
Davido is the second youngest of his father's five children and the youngest of his five siblings. While still a student at Oakwood, he parted with his musical equipment and began producing beats.
In addition to that, he helped his cousins B-Red and Sina Rambo form the musical act known as KB International. After deciding to pursue a career in music full-time, Davido withdrew from Oakwood University and moved to London, where he worked on perfecting his singing voice.
After relocating back to Nigeria in 2011, he decided to put an end to his career as a musician and instead enrolled at Babcock University in order to show respect for his deceased father.
After his father had paid the university to start a music department for an initial class of one student, he graduated from Babcock in July 2015 with a diploma in Music. His father had funded the establishment of the department.
Davido is an indigene of Ede, Osun State. He has real estate in several countries, including the United States of America, the United Kingdom, and Nigeria. He travels back and forth between Atlanta and Lagos on a regular basis.
He formerly called a mansion in the Lekki neighborhood of Lagos home. On the other hand, while the epidemic was going on, he relocated to a new house on Banana Island.
He is the father of three children: two girls and a boy, but he has not yet tied the knot. Aurora Imade Adeleke, his first kid, was born to him by his then-girlfriend Sophia Momodu when he was just nineteen years old. Chioma Avril Rowland, who is the mother of his son Ifeanyi Adeleke, was his ex-fiancee and they were engaged at one point.
Davido is widely regarded as the most successful and financially successful musician in Nigeria. The 30 Billion Gang reports to him as their boss.
Davido is well-known for his extravagant lifestyle as well as his charitable deeds, and he is the proud owner of a private aircraft. Davido is a self-made billionaire, in spite of the fact that he was born into an affluent family.
In addition to that, he is recognized as one of the most powerful brand influencers in the nation. He serves as the brand ambassador for several well-known companies, including Infinix Mobile, 1xBet, Martell, and Munch It. In addition to that, he had worked as a brand ambassador for the telecoms business known as MTN.
Davido already has three children from a previous relationship, and he just announced his engagement to Chioma Avril Rowland, the mother of his third kid.
HKN
Together with his older brother, Adewale Adeleke, Davido Adeleke established HKN Music. At this point in time, the record label might be considered the artist's home. In addition, he has produced music for a number of performers, including Skales, Tiwa Savage, Naeto C, and a great deal of other larger Acts.
Davido Music Around the World (DMW)
In 2016, Davido established his record company under the name Davido Music Worldwide. Soon after he signed a contract with Sony Music, he established the company.
A significant number of prominent performers signed their names underneath the label's mark. Teli, Peruzzi, Mayorkun, and Dremo are among the people who make up a portion of them, amongst others.
Davido's estimated wealth
Davido has been working in this field for more than 10 years, and during that time he has acquired a wealth through sponsorship agreements, playing at music concerts, and organizing his own performances.
In addition to this, he is an entrepreneur who has made successful investments in businesses located all over the world.
It is believed that Davido's net worth is thirty million dollars.
Davido Endorsement
On April 6, 2012, the publication Nigerian Entertainment Today reported that Davido has inked an endorsement deal with MTN for 30 million naira. As part of the arrangement, he became the public face of MTN Pulse, a marketing and advertising campaign geared toward young people in Nigeria. MTN Pulse targets Nigerian teenagers.
The news that Davido has inked an endorsement contract with Guinness Nigeria was reported by Pulse Nigeria on October 24, 2013.
Davido performed in the Guinness International of Extra Concert among other musicians such as P-Square, D'banj, Wizkid, Ice Prince, Burna Boy, Olamide, Phyno, Chidinma, Waje, and Tiwa Savage as part of the agreement.
The announcement that Davido has inked an endorsement deal with Infinix Phone, a phone company located in Hong Kong, was made public by Guardian Life on May 9, 2018.
On Instagram, Davido has the second-most followers of any African artist. On the platform, he is followed by more than 21.5 million people.
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Every time an independent restaurant closes, I get a little melancholy.
So far this year Gio Taco, The Dish and Mexico in Season have closed as well others. Contigo closes tomorrow May 17 and Bluefin on May 24.
While Bluefin closes, its sister restaurant Kingfisher Bar & Grill will rock on despite whatever havoc will be wrecked on Grant Road.
I ate at Bluefin only a handful of times because it's not in my geographic radar but each time was memorable. Tonight my friends and I decided to go and Bluefin was hopping with energy and professionalism.
What makes a restaurant good? Besides the choices, freshness and precise food preparation — I'd definitely add knowledgeable and attentive service, pricing, honoring reservations (none of this wait in the bar business) and an overall vibe permeating the room watching other diners enjoy their food and each other.
It's amazing how many restaurants cannot cover those bases.
So if you have time to go to Bluefin before they close, let me recommend the grilled salmon entree and the cashew crusted Hawaiian fish entree. Every morsel on these plates were swept into our happy mouths. And then there's the olive oil cake with blood orange syrup. Whoever heard of such a thing? Don't know, but glad they did.
Casas Adobes Plaza will never be the same.


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Oehme oder Öhme ist der Familienname folgender Personen:

 Adam Gottfried Oehme (1719–1789), deutscher Orgelbauer
 Arthur Oehme (1885–1965), deutscher Zeichner, Illustrator und Porzellanmaler
 Carl Gustav Oehme (1817–1881), deutscher Mechaniker und Fotograf (Daguerreotypist).
 Christian Gotthilf Immanuel Oehme (1759–1832), deutscher Maler
 Curt Oehme (1883–1963), deutscher Internist
 Dorothea Oehme (* um 1956), Germanistin und Verlegerin
 Elsa Oehme-Förster (1899–1987), deutsch-amerikanische Sopranistin und Filmschauspielerin
 Erich Oehme (1889–1970), deutscher Bildhauer
 Ernst Ferdinand Oehme (1797–1855), deutscher Landschaftsmaler
 Erwin Oehme (Ernst Erwin Oehme; 1831–1907), deutscher Maler
 Franziska Oehme (* 1944), deutsche Schauspielerin
 Felix Oehme (1981), deutscher Segler
 Georg Egmont Oehme (1890–1955), deutscher Maler
 Günther Oehme (* 1938), deutscher Chemiker
 Hanns Oehme (1899–1944), deutscher Maler und Kakteenkenner
 Hugo Oehme (1873–1952), deutscher Maler und Graphiker
 Johann Christoph Oehme (1675–1745), deutscher Orgelbauer und regierende Bürgermeister von Lucka
 Johannes Oehme (20. Jahrhundert), deutscher Pädiater, Mitarbeiter von Werner Catel
 Karin Oehme (* 1946), deutsche Schauspielerin
 Mario Oehme (* 1964), deutscher Bogenschütze
 Matthias Oehme (* 1954), deutscher Verleger
 Michael Oehme (* 1950), Schweizer Chemiker

 Philipp Oehme (* 1981), deutscher Schauspieler und Sänger
 Ralph Oehme (* 1954), deutscher Theater- und Hörspielautor, Librettist und Schauspielpädagoge
 Reinhard Oehme (1928–2010), deutsch-amerikanischer, theoretischer Physiker
 Roland Oehme (1935–2022), deutscher Drehbuchautor und Regisseur
 Ruthardt Oehme (1901–1987), deutscher Geograph, Kartograph und Bibliothekar
 Thomas Oehme (* 1970), deutscher Handballspieler und -trainer
 Ulrich Oehme (* 1960), deutscher Politiker (AfD)
 Walter Oehme (1892–1969), deutscher Journalist und Politiker (SPD, USPD)
 Wolfgang Oehme (1923–2000), deutscher Industriemanager
 Wolfgang Oehme (1930–2011), deutscher/US-amerikanischer Gartengestalter

Siehe auch:
 Oehmen


My quarrel is not with you, outspoken dissenter, nor is it even with NFL Commissioner Roger Goodell. My point is simple: we should not try to conquer this beautiful game because we risk losing the very essence of what makes it beautiful. Cities and fans unite every week to support their team and leave behind the daily grind, if only for a few hours, because football takes them there. Smoked meats and simmering chilis spooned from styrofoam bowls in sub freezing weather because it takes them there. 80,000 who don't know each other become family when Tom Brady throws a 37 yard touchdown pass to Rob Gronkowski on 4th down in the final minute of the game because they need someone to embrace, and because it takes them there.
Football belongs to all of us, and so should the words we use to describe it.
The AFC Champion Denver Broncos squeaked out a victory by the thinnest hair on their manes to secure a spot in the big game behind a dominating 2-and-a-half sack performance by outside linebacker and Texas A&M product Von Miller. The Denver defense made golden boy Tom Brady look mortal, and the Patriots offense never really got going until midway through the 4th quarter. Expect much of the same from that Denver front seven on Sunday.
Meanwhile, the NFC Champion Carolina Panthers turned over Carson Palmer and the 13-3 Arizona Cardinals six times en route to a 49-15 drubbing which ended fittingly in a Luke Keuchly interception returned for a touchdown (more on him later).
Will this indeed be Sheriff Peyton Manning's last rodeo? How will the anemic Broncos offense put up points, or even yards, against that #KeepPounding Panthers D? Will Demaryius Thomas shake his recent funk and remind us why he's one of the best wide receivers in the league?
It's hard to believe this will be Cam Newton's third championship game in his football career, the others being wins with Blinn Junior College and Auburn University. This will also be the first NFL championship game featuring two Heisman-winning starting quarterbacks, so we know we're in for a treat.
For the Broncos, look for Kubiac to try to establish Manning with short passes early, get him feeling it. If you see him twisting to Rocky Mountain High before the first timeout, it's probably a good sign.
For the Panthers, playing with a chip on their shoulder all season landed them as a five-point favorite in the big game. Carolina will rely on their defense to set the tone for the game. Everyone and their grandmother is picking the Panthers, and Cam Newton as the game's MVP, but I really think the impact Luke Keuchly is going to be the difference. His range as a linebacker is unheard of, and no one competes harder on every down.
As head coaching legend Herm Edwards famously said, "you play to win the game." I expect both teams to try to win on the defensive side of the ball and to not lose it on the offensive side. That's why I think the team that plays special teams better tomorrow night comes on top.
Great read!!! It is insightful with a touch of humor.


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Perspective > theheart.org on Medscape > American College of Cardiology (ACC) 2017 Scientific Sessions
FOURIER/EBBINGHAUS: So Far, So Good. But Can We Afford It?
Robert A. Harrington, MD; Clyde W. Yancy, MD, MSc
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Robert A. Harrington, MD: Hello. I am Bob Harrington from Stanford University. Thank you for joining us here on Medscape Cardiology and theheart.org. I am here at the American College of Cardiology Meetings in Washington, DC. I have a chance to discuss one of the late-breaking clinical trials, which came out yesterday, with my good friend and colleague, Dr Clyde Yancy, who is a professor of medicine and the chief of the Division of Cardiology at Northwestern University.
Clyde W. Yancy, MD, MSc: Go 'Cats, man.
Dr Harrington: We are here to talk about one of the biggest pieces of news that has come out of the meeting thus far, and that is the FOURIER trial,[1] the first of the large outcome studies with the PCSK9 inhibitors. Put it into context, Clyde. Why was the room not just standing-room-only but the overflow rooms also had lines to try to get in?
Dr Yancy: Putting it in context is really a great question, Bob, because one context is the generation of science and evidence. Another context is, what does it mean to a clinician? A third context is, what does it mean to patients?
Dr Harrington: Maybe a fourth context is, who is going to pay for all of this?
Dr Yancy: Very quickly—I love the story of the PCSK9 inhibitor. It began from observational data, something you and I understand and know very well. It was an aha moment—why is this group not having the same incidence of coronary disease and why would their LDL be so low? You discover that there is just this collection of people who had a loss and gain functionality of the gene for PCSK9.
Dr Harrington: A brilliant piece of science.
Dr Yancy: Amazing, and then it goes through a rapid throughput, given how things have to progress in today's world, and now you have an inhibitor that is monoclonal antibody. We go through the derivation monoclonal antibody. It is a terrific story in science. To see it go from idea, to data, to bench, to clinical trial testing, to outcomes is absolutely brilliant.
Dr Harrington: When you think about that time horizon, not that long from observation, to clinical outcome data... Although for those of us who have been waiting for the data, it seems like a long time.
Dr Yancy: I will have you answer this part because it was an exceptionally well-done trial. What I loved about it was that not only do they address the potential benefits but they also very carefully incorporated assessments of potential issues in safety.
No Mortality Reduction Not Necessarily Disappointing
Dr Harrington: Let's dive right into that. Here is the question that we knew. We know from a lot of work that has been done, particularly with the statins, that lowering LDL-C in people who are at high risk for coronary events is associated with improvement of clinical outcomes. That is a truism.
Dr Yancy: That is the LDL hypothesis. It is true.
Dr Harrington: It is true. We know from work done by the cholesterol trial, as collaboration in others, that there seems to be this very predictable relationship between level of LDL, amount lowered, and clinical outcome.[2,3] I thought that a nice addition to that at the lower end was the ezetimibe story: highly predictable, very modest effect on LDL, very modest effect on clinical outcomes.[4] That line keeps going, from over 200 mg/dL (5.2 mmol/L) now to about 60 mg/dL (1.6 mmol/L). Then the question was, what if we lower even further to levels of 20-30 mg/dL (0.52-0.78 mmol/L)? Would the curve keep going like this or would it start to flatten out?
Dr Yancy: Think about what they did in FOURIER: 27,000 patients, randomized to placebo or evolocumab, either once a month or twice a month, based on patient preference. I cannot wait to see the regularity of that.
Dr Harrington: They did not show details on that, but this is the first presentation.
Dr Yancy: You look at the study and you begin to see some remarkable effects. There was a 59% lowering of LDL-C. What I really loved was that when you looked at the interquartile range of the magnitude of LDL lowering, the lower bounds was 19 mg/dL. Twenty-five percent of the patients in this study had an LDL less than 19 mg/dL (0.49 mmol/L). Bob, that is what I call a pause moment. We never have conceptualized the possibility of being able to get LDL to that threshold.
Dr Harrington: The only thing that we knew about that was, again, from the observational epidemiologic studies, that there are populations with exceedingly low LDLs. We know that when we are born we have exceedingly low LDLs. It is our lifestyle over time that in some ways increases the level of LDL-C. The question was, is that protective in a group of patients who did not start down there, against future coronary events, and is it safe to push people from an LDL-C of 90, 70, 60 mg/dL down to 20 mg/dL?
Dr Yancy: What was very interesting was that when you looked at the composite endpoint, 15% improvement that incorporated a number of very important clinical observations, if you will—hard outcomes like stroke, death, and MI, but also revascularization, admission for unstable angina—that was truism again. I was really struck that there was a 20% relative reduction in the secondary endpoints—death, MI, and stroke—the stuff that matters every day in clinical practice.
I would not quibble and say that 2% absolute is not much. That is a lot for the leading cause of death and disability in this country.
Dr Harrington: A 2% absolute reduction. For the primary endpoint it was 1% absolute reduction.
Dr Yancy: I would not quibble and say that 2% absolute is not much. That is a lot for the leading cause of death and disability in this country. When you look at the landmark analysis, this is when I felt that I have just seen something spectacular, because at 2 years going forward and at 3 years going forward, you are talking about 33% effect size at reduction on events, the curves diverging still. That is impressive, and this was a relatively short trial. Who knows where the plateau is.
Dr Harrington: You just brought up some of the key issues, the first of which is that this was a really well-done trial—the completeness of the data, the high quality. Kudos to Marc Sabatine and the TIMI Group.
Dr Yancy: Absolutely.
Dr Harrington: The choice of the primary endpoint versus the secondary is interesting. You heart failure guys have done this for years, where the primary endpoint is this expanded composite and then the secondary endpoint is what you really care about.
Dr Harrington: Traditionally, what happens is that you are way overpowered for the first and you lose for the second. You are hoping that you really hit it here [secondary endpoint], and you hit it here.
Dr Yancy: This study was actually powered for the secondary endpoint, which was great. If you continue this dynamic and look at the other side of the coin, they had the presence of mind to a priori assess for diabetes and cataracts—the things that worry the everyday patient who is exposed to these therapies. Other than some injection-site issues, it was pretty safe.
Dr Harrington: It appears very safe. We will get into the neurocognitive stuff in a minute. I want to tease through the components of the endpoint first. In some ways, they overthought the problem that the results were flat for unstable angina with hospitalization. That just became noise, and it did not actually help tease out the treatment effect. All of the treatment effect is in MI and stroke, and big effects in MI and stroke.
Dr Yancy: That makes us have to say something that is very important which was that we did not see an effect on death. There are some people who say that it is a disappointment, but statin therapy is very good therapy. These are benefits over and above what you get with statin therapy. I am not disappointed that we did not see a mortality benefit.
Dr Harrington: I am not quite there. I really thought that there would be a reduction in mortality. I am happy with an MI stroke diminution. You commented earlier about the landmark analysis—I'm concerned that we just did not follow these patients long enough; the median was 26 months. Statin trials followed people a lot longer, the ones that showed mortality benefits. I think the mortality question is still open.
Dr Yancy: As we follow it longer, we will see what happens there.
Dr Harrington: I am hoping that there is a message in the follow-up trials that are coming. I am involved with the ODYSSEY Outcomes trial and we as a study group will have tough conversations about whether to extend the follow-up; now that we have seen external data, should we go longer? I do not know the answer to that, but maybe.
Dr Yancy: This is a question, because we have already addressed two questions that we think are important. What about once a month versus twice a month? What about the longer-term issue on mortality? I also would like to see a little bit more granularity on the patient groups within the trial, understand more about women versus men; understand more about older, younger, white, non-white. Those data will come forward and will help us.
Dr Harrington: They did show that one forest plot. As you know, getting ready for this meeting, I am sure it was a last-minute preparation.
Costs and Clinical Practice Changes
Dr Yancy: Here is the real question on the table. Now that we have this information, we have talked about this brilliant history through science and this great clinical trial.
Dr Harrington: What are we going to do?
Dr Yancy: What are we going to do?
Dr Harrington: Here is where I think the careful work is going to have to be done, and that is the payer perspective. These drugs are really expensive right now. These drugs have really only been approved for familial hypercholesterolemiapatients, people with really high LDLs and we know we have to get their levels down.
Dr Yancy: It is almost an ethical thing.
Dr Harrington: Exactly, and now people are going to say, should we use them more broadly? I think that what is going to happen is the formal cost-effectiveness analyses have to be done, but I do not think they are going to support the current price point.
Dr Yancy: That is going to be hard.
Dr Harrington: The companies are going to have to rethink that price point. Given that data, I would like to use them in my patients, but I am not sure that, at that price point, the system can bear that.
Dr Yancy: There has to be some discounting. There is one other data point that might influence that decision. I would look to see what happens in lipoprotein(a) [Lp(a)] because there are a number of patients who are at risk particularly because of that, and these drugs do lower Lp(a).
Dr Harrington: Can we pick out a group that maybe gets preferential benefit? That is why your comment is so important, Clyde, about the subgroups. Let's just talk quickly about neurocognitive function, which had also been a concern. That looks to have been put to rest.
Dr Yancy: Can we just say that EBBINGHAUS[5] basically settled that question?
This is for secondary prevention; nothing that we are talking about applies to primary prevention. There are cost issues that remain.
Dr Harrington: It looks pretty good, does it not? Multiple measures of cognitive function. Patient-reported changes in cognitive function. All of it looks pretty flat, good sample size, nicely reported.
Dr Yancy: When you look at the cognitive study and at the methodology, those are some pretty smart people.
Dr Harrington: My own cognitive function was really put to the test while reading the methods of the paper. I do think, from an overall safety perspective, that the drug looks pretty good.
Dr Yancy: Why don't we wrap up and simply say, this is a new era because we can do more for atherosclerotic cardiovascular disease now than we could before. The target patient is the high-risk patient who has already been effectively treated with statin therapy but has not yet had a reduction in LDL to less than 70 mg/dL. This is for secondary prevention; nothing that we are talking about applies to primary prevention. There are cost issues that remain, but we should all be engaged and think about using this appropriately going forward.
Dr Harrington: Great summary. I am looking forward to seeing what the guideline writers do. In particular, I am interested in whether they will readdress the issue of LDL-C targets.
Dr Yancy: That will be very interesting.
Dr Harrington: It's going to be a good discussion. Do you want to close us out, Clyde?
Dr Yancy: Thank you. Thank you very much for watching Medscape, theheart.org, as Bob Harrington and I have been reviewing this incredible set of data points. It really opens up a new arena in cardiovascular medicine. Thank you for your attention.
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: FOURIER/EBBINGHAUS: So Far, So Good. But Can We Afford It? - Medscape - Mar 23, 2017.
Robert A. Harrington, MD
Arthur L. Bloomfield Professor of Medicine and Chair, Department of Medicine, Stanford University, Stanford, California
Disclosure: Robert A. Harrington, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Bristol-Myers Squibb Company; Gilead Sciences, Inc.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Merck & Co., Inc.; MyoKardia; Orexigen Therapeutics, Inc.; Portola Pharmaceuticals, Inc.; Regado Biosciences; Sanofi; WebMD
Received grants for clinical research from: American College of Cardiology; American Heart Association; National Heart, Lung, and Blood Institute; National Institute of Aging; AstraZeneca Pharmaceuticals LP; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; GlaxoSmithKline; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Eli Lilly and Company; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; Portola Pharmaceuticals, Inc.; Regado Biosciences; Sanofi; The Medicines Company
Clyde W. Yancy, MD, FACC, FAHA, FACP
Vice Dean, Diversity & Inclusion, Magerstadt Professor Medicine, Professor of Medical Social Sciences, Chief, Division of Cardiology, Northwestern University Feinberg School of Medicine; Associate Director, Bluhm Cardiovascular Institute, Northwestern Memorial Hospital, Chicago, Illinois
Disclosure: Clyde W. Yancy, MD has disclosed no relevant financial relationships.
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Evolocumab Added to Statins Cuts CV Events in FOURIER Trial
Ten Quick Thoughts on FOURIER


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FIRST LOOK: Watch a Teaser Trailer from 'Snowden', Coming December 2015
June 30, 2015 By Funmbi Leave a Comment
"One nation, under surveillance, for liberty and justice for all." Open Road Films releases the first teaser trailer and images from upcoming thriller, Snowden.
Earlier today, Open Road Films released the first teaser from their upcoming thriller, Snowden. Written and directed by Academy Award-winning director Oliver Stone, Snowden features an all-star cast including Joseph Gordon-Levitt, Shailene Woodley, Melissa Leo, Zachary Quinto, Tom Wilkinson, Rhys Ifans, and Nicolas Cage.
The script is based on the books The Snowden Files: The Inside Story of the World's Most Wanted Man by Luke Harding and Time of the Octopus by Anatoly Kucherena. Check out the trailer below, which details the history of Edward Snowden's U.S. service, from an Army recruit at 20 years old, to his work at the NSA, which would eventually make him the most wanted man in the world:
While the trailer doesn't have any footage from the film, it's still pretty eerie, especially with that version of "This Little Light of Mine" in the background.
Take a look at these two images from Snowden which feature Joseph Gordon-Levitt as Edward Snowden during his military service and then later in Washington D.C. with his girlfriend Lindsay Mills (played by Shailene Woodley):
Courtesy of Open Road Films
Snowden hits theaters everywhere on December 25, 2015.
Twitter: Twitter.com/snowdenthemovie
Facebook: Facebook.com/Snowdenthemovie
Instagram: Instagram.com/SnowdenTheMovie
Snapchat: SnowdenTheMovie
Website: snowdenfilm.com
#SnowdenMovie
Filed Under: Film, News Tagged With: #SnowdenMovie, Edward Snowden, film trailer, Joseph Gordon-Levitt, Melissa Leo, movie trailer, Nicolas Cage, Oliver Stone, Open Road Films, photos, Rhys Ifans, Shailene Woodley, Snowden, teaser trailer, Tom Wilkinson, video, Zachary Quinto
RECAP: 'The White Princess' Season 1 Premiere "In Bed With The Enemy"


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Botta kan syfta på:

 Botta, äldre dialektalt namn på piggvar

Geografi

Italien

 Botta (ort), Lombardiet, Provincia di Bergamo,
 Botta (kommunhuvudort), Lombardiet, Provincia di Bergamo,

Robotskapade Italienförgreningar


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Home » Colombia
Tul Raises $181M in Series B Funding
Tul, a Bogota, Colombia-based e-commerce platform that strengthens developing communities by providing locally-run hardware stores with consistent access to construction materials, inventory management capabilities, invoicing services and opportunities to diversify revenue streams, secured $181m in Series B funding.
Published on January 12, 2022 January 12, 2022 By FinSMEs
Osigu Raises US$7.5M in Funding
Osigu, a Miami, Florida-based real-time claims processing and e-prescription platform in Latin America, secured $7.5m in funding.
Published on December 21, 2021 December 21, 2021 By FinSMEs
Platzi Raises $60M in Series B Funding
Platzi, a professional education platform in Latin America, raised $60m in Series B funding.
Published on December 6, 2021 December 6, 2021 By FinSMEs
Addi Raises $140M in Series B Extension Funding
Addi, a fintech and digital commerce startup based in Bogota, Colombia, and Sao Paulo, Brazil, raised $75m in extension Series B funding.
Published on September 9, 2021 September 9, 2021 By FinSMEs
Demetria Emerges from Stealth With $3M in Seed Funding
Demetria, a Bogota, Columbia- and Herzliya, Israel-based AI-powered taste and quality intelligence SaaS startup for the coffee supply chain, emerged from stealth after closing a $3m seed funding round.
Published on March 2, 2021 March 2, 2021 By FinSMEs
Chiper Raises $12M in Series A Funding
Chiper, a Colombian e-commerce platform for independent merchants, raised $12m in Series A funding.
Published on October 19, 2020 October 19, 2020 By FinSMEs
SVB Financial Group Closes $30M Latin America Growth Lending Fund
SVB Financial Group (NASDAQ: SIVB), a Santa Clara, Calif.-based venture debt bank, closed a new $30m venture and growth debt fund.
Published on July 15, 2020 July 15, 2020 By FinSMEs
Habi Raises $5.5M in Pre-Seed Funding
Habi, a technology-driven real estate company based in Bogotà, Colombia, raised $5.5m in pre-seed funding.
Published on November 15, 2019 By FinSMEs
Leal Raises US$3M in Funding
Leal, a Bogota, Colombia-based loyalty startup, raised US $3m in funding.
Published on June 7, 2019 By FinSMEs
Civico Receives Investment from Accion
Civico, a Bogotá, Colombia-based digital platform that enables access to information and services to improve the quality of life of individuals in Latin America, received an investment from global nonprofit Accion.
Published on April 4, 2019 By FinSMEs
SoftBank Group Launches $5 Billion Technology Growth Fund for LatAm
Global technology company SoftBank Group Corp. has launched the SoftBank Innovation Fund, the technology fund focused exclusively on the Latin American market.
Published on March 22, 2019 By FinSMEs
EdgeUno Raises $500k in Seed Funding
EdgeUno, Inc., an edge computing startup, raised $500k in seed funding.
Published on February 11, 2019 By FinSMEs
Lentesplus Receives US$5M in Equity Funding
Lentesplus.com, a Bogotá, Colombia-based e-commerce platform for contact lenses in Latin America, received US$5m in equity funding.
Polymath Ventures to Raise $100M Latin American Fund
Polymath Ventures, a Bogotá, Colombia- and Mexico City, Mexico-based based company builder focused on the middle class in emerging markets, is raising a $100m investment fund.
Published on November 6, 2018 By FinSMEs
Magma Partners Launches $15M Fund to Support LatAm Startups; Announces First China-LatAm Accelerator
Magma Partners, an early stage venture capital firm with offices in the U.S. and Latin America, has held the first close of its second $15M fund.
Published on February 7, 2018 By FinSMEs


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Foucault pendulum: Foucault pendulum, called a Foucault pendulum, suspended from a long cable with markers to show that its plane of motion Article History.
These small wonders have a long history. Next we need to think about what kind of a pendulum do I need? How do I choose one. How does a pendulum move?
Exploring Pendulums Student Activity Sheet Materials. Pencils; Three lengths of string (30 cm, of a pendulum is independent of the pendulum's mass.
History Edit Pre War events Edit. Decades before the Pendulum wars, Sera was plunged in the millennia long conflict known as the Age of Armageddon, nearly destroying both the human race and Sera.