text:
Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34)
R34 Clinical Trial Planning Grant Program
Reissue of PA-09-146
April 7, 2015 - This PA has been reissued as PA-15-177.
June 3, 2014 - Notice NOT-14-074 supersedes instructions in Section III.3 regarding applications that are essentially the same.
May 30, 2013 (NOT-OD-13-074) - NIH to Require Use of Updated Electronic Application Forms for Due Dates on or after September 25, 2013. Forms-C applications are required for due dates on or after September 25, 2013.
93.279, 93.273
This FOA for R34 applications seeks to support: (a) pilot and/or feasibility testing of new, revised, or adapted preventive intervention approaches targeting the initiation of drug and alcohol use, the progression to abuse or dependence, and the acquisition or transmission of HIV infection among diverse populations and settings; and (b) pre-trial feasibility testing for prevention services and systems research. This R34 mechanism does not support the development of intervention protocols, manuals, or the standardization of protocols. It is expected that research conducted via this R34 mechanism will consist of early stage efficacy, effectiveness or services research that will provide intervention pilot and/or feasibility data that is a pre-requisite for submitting larger drug or alcohol abuse and/or drug- or alcohol-related HIV prevention intervention studies. Particularly highlighted are prevention interventions targeting the health care system.
Letter of Intent Due Date
Standard dates apply, by 5:00 PM local time of applicant organization.
Earliest Start Date(s)
New Date April 7, 2015 per issuance of PA-15-177. (Original Expiration Date: May 8, 2015)
It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
This FOA for R34 applications seeks to support: (a) pilot and/or feasibility testing of new, revised, or adapted preventive intervention approaches targeting the initiation of drug or alcohol use, the progression to abuse or dependence, and the acquisition or transmission of HIV infection among diverse populations and settings; and (b) pre-trial feasibility testing for prevention services and systems research. This R34 mechanism does not support the development of intervention protocols, manuals, or the standardization of protocols. Rather, this mechanism is intended for research that aims to test: (1) novel preventive interventions based on translation of basic science findings; (2) preventive interventions in use that are untested; (3) novel approaches to taking efficacious interventions to scale in broad population settings; (4) novel preventive interventions in settings not previously studied; or (5) effects of combining multiple efficacious or effective interventions in ways that have a likelihood of demonstrating additive or multiplicative effects. Particularly highlighted are prevention interventions targeting the health care system. It is expected that research conducted via this R34 mechanism will consist of early stage efficacy, effectiveness or services research that will provide intervention pilot and/or feasibility data that is a pre-requisite for preparing and submitting larger drug or alcohol abuse and/or drug- or alcohol-related HIV prevention intervention efficacy and effectiveness trials, or prevention services and systems research studies. Efficacy trials are designed to establish the impact of a preventive intervention approach on targeted outcomes under ideal implementation conditions. Effectiveness trials replicate efficacious strategies and interventions in less controlled, real-world settings with larger more diverse samples, and generally employ a randomized controlled trial (RCT) or equivalent research design (such as, multiple baseline, cross over, etc.). In preparation for efficacy and effectiveness research, pilot studies are typically conducted to gather evidence of feasibility and potential efficacy/effectiveness in advance of proposing full-scale trials.
Prevention services research forms the link between efficacy and effectiveness research on prevention interventions and adoption of evidence-based prevention practice in real world settings. In preparation for large scale prevention services and systems research projects, pilot studies are often needed to empirically test and establish evidence for the feasibility of intervention protocols, implementation and fidelity measures, or training and implementation methodologies. Applications to this R34 FOA are not required to present pilot data in support of the proposed hypotheses and aims; rather a well defined theory of change or logic model and associated hypotheses are expected. Thus, applications are not penalized for a lack of preliminary data supporting the proposed hypotheses and aims. Applicants are encouraged to provide strong evidence of their capability to conduct the proposed study, through documenting the availability of needed resources, evidence of institutional support, the training and experience of the investigator team, and/or the conduct of related studies.
Exploratory or pilot research studies for purposes other than collecting pilot or feasibility data for use in later, larger-scale studies should not be submitted under this FOA. However, they may be appropriate for submission to the R21 FOAs on Drug Abuse Prevention Intervention Research (PA-11-312) and Epidemiology and Prevention in Alcohol Research (PA-11-018).
Significant progress has been made in understanding effective approaches to prevention of drug and alcohol abuse over the past few decades, in part because of the careful attention given to understanding basic developmental processes involved in the transition to drug and alcohol use, abuse and dependence. Drug and alcohol abuse and dependence are disorders that interfere with the normal, healthy functioning of persons across the lifespan, and are preventable causes of health problems, injuries, lost income and productivity, and family dysfunction.
While the initiation of licit and illicit drug use, a necessary precursor to abuse and dependence, grows dramatically during the adolescent years, this behavior is preceded by proximal and distal biological, psychological, social, and environmental precursors originating as early as the prenatal period. Furthermore, initiation and progression of misuse of licit and use of illicit drugs extends well beyond adolescence and, for some, begins in adulthood, including late adulthood. Drug use has many consequences beyond the potential for dependence and addiction. Drug use is associated with increased risk of HIV exposure due to physiological, cognitive, social and/or emotional effects and constitutes a substantial risk for HIV acquisition.
Alcohol is the most widely used substance among U.S. adolescents and adults, and alcohol consumption is only illegal in a subgroup of the population (under-aged drinkers). Initiation of alcohol use can occur as early as pre-adolescence, with the highest prevalence occurring in young adulthood. Early initiation of heavy drinking is associated with increased risk for developing an alcohol use disorder. Many of the consequences of alcohol use depend on developmental timing and pattern of use or exposure. For example, binge drinking in women of childbearing age is associated with fetal alcohol spectrum disorder in the offspring. In addition, developmental processes occurring in the brain during adolescence and the sensitivity of these processes to alcohol may be responsible for some of the long-term consequences of adolescent binge drinking.
The life course developmental perspective suggests that individual and environmental factors interact to increase or reduce vulnerability to drug and alcohol use, abuse and dependence. Vulnerability can occur at many points along the life course but peaks at critical life transitions. Thus, prevention researchers should recognize the significance of timing interventions to coincide with important biological transitions, such as puberty; normative transitions, such as moving from middle to high school; social transitions, such as dating; and traumatic transitions, such as the death of a parent, spouse or significant other. In addition, because vulnerability to drug and alcohol abuse involves dynamic intrapersonal (e.g., temperament), interpersonal (e.g., family and peer interactions, role expectations) and environmental (e.g., school environment, neighborhood characteristics, cultural and subpopulation norms) influences, prevention intervention research must target interactions between individuals and social systems across the life span. To address this complexity, intervention research needs to test strategies designed to alter modifiable mediators to determine which are most related to drug and alcohol use initiation and escalation and its consequences such as acquisition and transmission of HIV. Mediating conditions often are nested in particular settings or social groupings and effective interventions need to take these factors into consideration. Drug and alcohol use, abuse, and dependence often co-occur with delinquency and criminal behavior, interpersonal violence (bullying and victimization), mental health problems, school failure, sexually transmitted infections (including HIV), and reproductive health problems. Therefore, understanding the prevention of co-occurring problems and their contribution to elevated levels of substance use risk is important to NIDA's and NIAAA's mission.
Successful drug abuse and drug-related HIV prevention programs have utilized a number of theoretical perspectives for predicting differential drug use trajectories and elucidating developmentally grounded mediators, or risk and protective factors, amenable to change. Testing of new intervention perspectives based on an understanding of emergent basic behavioral and biomedical research is encouraged, along with integration of emerging biomedical agents for HIV prevention. Resulting research has focused on prevention approaches involving positive modification of various precursors of substance use, such as emotional dysregulation, sensation-seeking, aggressive behavior, academic problems and failure, poor social skills, misperceptions of social norms, poor parent-child attachment, and inappropriate parental expectations and responses. Many of these same approaches have been incorporated into HIV prevention interventions in populations where drug use or risk for drug use is highly prevalent. HIV prevention efforts may benefit from further consideration of concepts and methods which have proven useful for drug abuse prevention, in general, with attention to appropriate developmental (e.g., sexual debut, exploration of sexual orientation and identity, change in relationship status) and contextual (e.g., cultural practices and social norms, background prevalence of sexually transmitted infections) factors. Because theoretical grounding of prevention programs is an essential feature for their success, further progress in prevention research relies on a stronger understanding and refinement of successful theories and their application and potentially the development of new theoretical approaches or meta-theories.
Prevention context impacts upon the feasibility, acceptability, and effectiveness of prevention approaches. Successful programs have intervened in varied contexts, such as schools, health care settings, tribal settings, community service organizations, and workplaces. Substance use and related HIV prevention research is most successful when the intervention delivery contexts provide ready access to the target population. That is, the more central the delivery context is to the target audience's existing life routines, the more likely the intervention and associated research will be able to recruit and retain members of the target population. Efforts to develop new modalities and methods for intervention delivery are needed, as new contexts for substance use become evident (e.g., social media), new technologies for intervention develop (e.g., eHealth, mHealth), and new service delivery settings emerge.
Audiences or targets for prevention interventions are generally classified into one of three categories depending on level of risk: universal, selective, or indicated. Universal prevention interventions are targeted to the general public or to a whole population group, such as all children in a school. Selective prevention interventions are targeted to individuals or subgroups of the population with defined risk factors for the development of substance abuse, such as children of drug and alcohol abusers, children of parents in the criminal justice system, youth in the child welfare system, adults receiving opiate analgesics for chronic pain, and young minority men who have sex with men. Indicated prevention interventions are targeted to individuals or subgroups that are identified as having non-clinical but detectable signs or symptoms foreshadowing drug abuse, dependence, and addiction; they also may be individuals whose substance use is episodic but problematic as in the case of elevated HIV sexual risk among stimulant users or driving under the influence of alcohol or drugs. A tiered approach to prevention interventions incorporates two or more of these levels of intervention with increasing intervention intensity for individuals at greater risk or with greater problem severity.
It is important to recognize populations where problem drug or alcohol use is emergent, particularly where co-morbidities or adverse consequences also are evident. Prescription drug abuse at various points in the life course, and methamphetamine initiation in middle age among men who have sex with men are two domestic examples of this. Emergent epidemics of opiate injection in the former Soviet Bloc, and various forms of substance use along international trafficking routes in Asia and Africa represent some international examples.
To advance the field, novel interventions must build on basic science findings from diverse fields. Opportunities exist to incorporate neurological, genetic and physiological measures to better understand the impact of prevention interventions on individual functioning across the course of development. Furthermore, because of recent advances in a number of disciplines, important opportunities exist to build upon findings from drug and alcohol abuse etiology and epidemiology research and the fields of human development, biology, neurology, criminology, psychology, sociology, anthropology, and communications and technology. An interdisciplinary approach to prevention, with research teams comprised of scientists bringing complementary expertise and critical and innovative research paradigms, will strengthen prevention efforts. In addition, studies addressing the unique opportunities to examine the interaction between biological, interpersonal, intrapersonal, and environmental variables in the context of the design and implementation of prevention research need to be developed and tested.
This FOA for R34 applications seeks to support: (a) pilot and/or feasibility testing of new, revised, or adapted preventive intervention approaches targeting the initiation of drug and alcohol use, the progression to abuse or dependence, and the transmission of HIV infection among diverse populations and settings; and (b) pre-trial feasibility testing for prevention services research. This R34 mechanism does not support the development of intervention protocols, manuals, or the standardization of protocols. It is expected that research conducted via this R34 mechanism will consist of early stage efficacy, effectiveness or services research that will provide intervention pilot and/or feasibility data that is a pre-requisite for preparing and submitting larger drug or alcohol abuse and/or drug- or alcohol-related HIV prevention intervention studies.
This R34 mechanism provides resources for testing and evaluating the feasibility, tolerability, acceptability and safety of novel approaches to improving drug and alcohol use preventive interventions, and for obtaining preliminary data needed as a pre-requisite to a larger-scale (efficacy or effectiveness) preventive intervention or prevention services study. For NIDA, long-standing priorities include innovative approaches for addressing health disparities and criminal justice populations. Emerging areas of priority for NIDA include clinical medical settings (or the broader health care system), children in the welfare system, children of parents in the criminal justice system, the military and their families, brief interventions, physical activity, the built environment, and HIV prevention among non-injection drug using populations. Priorities for NIAAA include innovative approaches for addressing health disparities, prevention of underage drinking and negative birth outcomes associated with alcohol use, such as fetal alcohol spectrum disorder.
NIDA's and NIAAA's drug and alcohol prevention research programs are comprehensive in nature and fully reflect the prevention research mission, objectives, and study areas advanced by the Department of Health and Human Services and the National Institutes of Health. Examples of R34 topics are given below. These are illustrative and not exhaustive; investigators should not view the examples provided as limiting the areas of research of interest to NIDA and NIAAA.
A. Pilot and Feasibility Testing of New, Revised, or Adapted Interventions
The R34 mechanism is appropriate for pilot testing of new, revised, or adapted preventive interventions targeting drug or alcohol use or abuse, or prevention of HIV acquisition/transmission. This R34 mechanism does not support the development of intervention protocols, manuals, or the standardization of protocols. Rather, this mechanism is intended for research that aims to test: (1) novel preventive interventions based on translation of basic science findings; (2) preventive interventions in use that are untested; (3) novel approaches to taking efficacious interventions to scale in broad population settings, such as clinical medical settings or the broader health care system; (4) novel preventive interventions in settings not previously studied; or (5) effects of combining multiple efficacious or effective interventions in ways that have a likelihood of demonstrating additive or multiplicative effects.
Examples of possible pilot and feasibility studies include, but are not limited to:
Feasibility testing of screening and brief universal interventions for use in clinical and medical settings and the broader health care system (e.g., primary care, obstetrics and gynecology, pediatrics, and adolescent medicine)
Studies that develop and test comprehensive community approaches that target multiple drug- and alcohol-related HIV outcomes across health, justice, education, and social service settings and systems
Using measures of basic biological (e.g. neurobiological, developmental neuroscience), psychological (e.g. emotional, behavioral, cognitive, and developmental) and social (e.g. social learning, peer network, and communications) functioning to better understand the mechanisms of change in substance abuse prevention or HIV prevention interventions
Studies that evaluate application of new HIV prevention modalities in drug and alcohol using populations
Studies that evaluate the application of new technologies for delivering prevention interventions
Studies that test the additive effects of implementing linked preventive interventions across contexts
Pilot testing of interventions to prevent prescription drug abuse in persons in treatment for conditions associated with chronic or acute pain
Studies of interventions to reduce drug- and alcohol-use related injuries and accidents, including suicide, motor vehicle crashes, and other problems
Research aimed at developing improved alcohol and drug use prevention strategies for high risk populations such as Native American/Alaska Natives, children of substance users, and underage drinkers
B. Feasibility Testing for Prevention Services Research
An important emphasis of NIDA's and NIAAA's prevention research programs is on prevention services research questions. Prevention services research forms the link between efficacy and effectiveness research on prevention interventions and adoption of evidence-based prevention practice; as such it involves identifying and determining how an intervention's internal and external features contribute to efficacy and effectiveness in services settings. Examples of internal features are: content, implementation strategies, fidelity, dosage, delivery setting and implementer training. Examples of external features are: exposure to other programs, media, enforcement of regulations and laws related to drug and alcohol use and community norms pertaining to drug and alcohol use and abuse. Questions around features that concentrate on the availability, organization, management, financing and sustainability of prevention interventions fall into the broad category of prevention services research. In preparation for large scale prevention services research projects, pilot studies are often needed to empirically test or validate in advance the feasibility of intervention protocols, implementation and fidelity measures and monitoring systems, or training and implementation methodologies. Such studies would be most appropriate for research under this R34 pilot project mechanism.
Examples of possible feasibility studies include, but are not limited to:
Utilizing services marketing processes such as consumer input (e.g., the individual participants, community stakeholders, and agencies) to examine feasibility and maximize the fit between an intervention and consumer/community needs in new settings
Testing the feasibility of organizational change approaches that focus on changing the behavior of key stakeholders
Evaluating the feasibility of integrating substance use prevention into specific pre-existing infrastructures and systems such as medical settings (e.g., primary health care, obstetrics and gynecology, pediatrics, and adolescent medicine), as well as selected justice, education, and social service settings
Determining the feasibility of innovative strategies for retaining trained prevention personnel
Evaluating the feasibility and acceptability of integrating screening as well as biomedical and behavioral methods for HIV prevention in populations where substance use often occurs
HIV/AIDS Counseling and Testing Policy for the National Institute on Drug Abuse: In light of recent significant advances in rapid testing for HIV and in effective treatments for HIV, NIDA has revised its 2001 policy on HIV counseling and testing. NIDA-funded researchers are strongly encouraged to provide and/or refer research subjects to HIV risk reduction education and education about the benefits of HIV treatment, counseling and testing, referral to treatment, and other appropriate interventions to prevent acquisition and transmission of HIV. This policy applies to all NIDA funded research conducted domestically or internationally. For more information see https://grants.nih.gov/grants/guide/notice-files/NOT-DA-07-013.html.
National Advisory Council on Drug Abuse Recommended Guidelines for the Administration of Drugs to Human Subjects: The National Advisory Council on Drug Abuse (NACDA) recognizes the importance of research involving the administration of drugs with abuse potential, and dependence or addiction liability, to human subjects. Potential applicants are encouraged to obtain and review these recommendations of Council before submitting an application that will administer compounds to human subjects. The guidelines are available on NIDA's Web site at http://www.nida.nih.gov/about/organization/nacda/CouncilStatement.html.
Points to Consider Regarding Tobacco Industry Funding of NIDA Applicants: The National Advisory Council on Drug Abuse (NACDA) encourages NIDA and its grantees to consider the points it has set forth with regard to existing or prospective sponsored research agreements with tobacco companies or their related entities and the impact of acceptance of tobacco industry funding on NIDA's credibility and reputation within the scientific community. Please see (http://ww2.drugabuse.gov/about/organization/nacda/points-to-consider.html) for details.
The OER Glossary and the SF 424 (R&R) Application Guide provide details on these application types.
The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.
Applicants may request direct costs of up to $450,000 for three years. Although variations from year to year are permissible, in no case may any year be more than $225,000 in direct costs, and total direct costs for the entire project period may not exceed $450,000.
The maximum period is 3 years.
Historically Black Colleges and Universities (HBCUs)
Tribally Controlled Colleges and Universities (TCCUs)
Alaska Native and Native Hawaiian Serving Institutions
Eligible Agencies of the Federal Government
Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Applicant organizations must complete the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following registrations.
Central Contractor Registration (CCR) – must maintain an active registration, to be renewed at least annually
All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.
All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least 4-6 weeks prior to the application due date.
Eligible Individuals (Program Director(s)/Principal Investigator(s))
For institutions/organizations proposing multiple PD(s)/PI(s), visit the Multiple Program Director(s)/Principal Investigator(s) Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide.
NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed. Resubmission applications may be submitted, according to the NIH Policy on Resubmission Applications from the SF 424 (R&R) Application Guide.
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the "Apply for Grant Electronically" button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Required and Optional Components
The forms package associated with this FOA includes all applicable components, mandatory and optional. Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate "optional" components.
PHS 398 Research Plan Component
Resource Sharing Plan
Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the SF424 (R&R) Application Guide.
Foreign (non-US) institutions must follow policies described in the NIH Grants Policy Statement, and procedures for foreign institutions described throughout the SF424 (R&R) Application Guide.
Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission.
Organizations must submit applications via Grants.gov, the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration.
Applicants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.
Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide. Paper applications will not be accepted.
For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically.
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the Central Contractor Registration (CCR). Additional information may be found in the SF424 (R&R) Application Guide.
Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review, NIH. Applications that are incomplete will not be reviewed.
Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115.
Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD(s)/PI(s), do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?
If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Human Subjects Protection and Inclusion Guidelines.
When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.
Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; and 3) Genome Wide Association Studies (GWAS).
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) in accordance with NIH peer review policy and procedures, using the stated review criteria. Review assignments will be shown in the eRA Commons.
May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact/priority score.
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD(s)/PI(s) will be able to access his or her Summary Statement (written critique) via the eRA Commons.
Any application awarded in response to this FOA will be subject to the DUNS, CCR Registration, and Transparency Act requirements as noted on the Award Conditions and Information for NIH Grants website.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
Grants.gov Customer Support (Questions regarding Grants.gov registration and submission, downloading or navigating forms)
Contact Center Phone: 800-518-4726
Email: GrantsInfo@nih.gov
eRA Commons Help Desk (Questions regarding eRA Commons registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
Email: commons@od.nih.gov
Jacqueline Lloyd, Ph.D.
Health Scientist Administrator
Prevention Research Branch
Division of Epidemiology, Services and Prevention Research
6001 Executive Blvd., Room 5166
E-mail: lloydj2@nida.nih.gov
Judith A. Arroyo, Ph.D.
Minority Health and Health Disparities Coordinator
5635 Fishers Lane, Room 2011
Grants Management Branch
Email: mconnell@nida.nih.gov
Chief, Grants Management Branch
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92. ICs should insert IC-specific regulations if applicable.


34 days after, man who began trekking against President Buhari's 2019 presidential ambition from Lagos State arrives Abuja - SWANKYLOADED OFFICIAL BLOG.
A lone trekker, Isa Mohammed Munlaila, who began trekking from Lagos to Abuja last month, against President Buhari's 2019 presidential ambition, has arrived Abuja after spending 34 days on the road.
Munlaila left Lagos on 23 August and arrived Abuja on Tuesday. He said he was fulfilled to have trekked the distance from Lagos to Abuja against the second term aspiration of Buhari.
Speaking with PM News, Munlaila said he normally trekked from 6.00am to 6.00pm on daily basis and then slept somewhere before continuing his journey to Abuja. He had initially planned to reach Abuja between 18 and 20 days, but because of a sore leg, the journey lasted for 34 days.
"As I trekked, I saw people angry with this present government because of hardship and failure to deliver on what was promised. When people see me, they hailed me for trekking. Some people were asking me if I was doing it for some political parties and I said no, but for the youths of this country. We are for good governance," he said.
Munlaila, who said he is not a politician, however, said based on people's view during his trek from Lagos to Abuja, he would endorse the aspiration of former Vice President, Atiku Abubakar to become president next year.
According to him, from his interaction with people, they preferred the candidacy of Atiku among all Peoples Democratic Party, PDP, presidential aspirants because of his achievement. He said when he got to Abuja, he went to the PDP National Secretariat and asked to see the National Chairman of the party, but was told he was away.
"Because of what I have heard during my trek, I will endorse Atiku for 2019 presidency. If Atiku has the chance to govern, Nigeria will be a better place," he said.
For him, Isa Munlaila, who had just arrived Abuja after embarking on an angered trekking from Lagos, against President Muhammadu Buhari's 2019 presidential ambition, his 34 days journey, which he began about 40 days ago, worth the sacrifice, saying his action was to registered youth anger over current state of the nation. Having spent 34 days on road Munkaila, who left Lagos over a month ago, arrived Abuja yesterday evening, during which he said he was fulfilled to have trekked the distance from Lagos to Abuja against the second term aspiration of Buhari.
Speaking about on the journey on Tuesday, the young Nigerian hinted that he tekked minimum of 12 hours on daily basis and then slept anywhere night meets him, and continuing his journey to Abuja. He had initially planned to reach Abuja between 18 and 20 days, but because of a sore leg, the journey lasted for 34 days.


Gardai have recovered a huge haul of stolen power tools while on patrol at 5am on Saturday morning, November 5.
They stopped and searched a vehicle towing a trailer close to Mountmellick, Co. Laois.
On searching the vehicle they discovered the power tools.
There has been a spate of power tool thefts in Offaly and Laois in recent weeks.
Gardai are currently identifying property and cataloging the haul.
If you recognise any property email laoisoffaly.crimeprevention@garda.ie.


Carlos Goffi has a very impressive coaching resume, listing John McEnroe and Mary Carillo among his successful charges. In this week's throw-back episode from 2013, Coach Goffi shares how he learned to coach, why he feels young athletes should play a variety of sports, and why it is so important for us as parents to learn how to control our emotions and body language as we watch our young players compete in the classroom, on the field, or on the court.
This episode was recorded several years ago as I was driving with my son back from Mobile, Alabama, where we had spent the long weekend at a junior tournament. Listening to it today brings back so many memories and emotions of my years traveling with my son! Having just returned home from spending a long weekend with him and my daughters in Los Angeles, I am reminded of how tennis helped cement a bond between us that I hope will last forever. Tennis is truly the gift that keeps on giving!
You can find Carlos Goffi's book, TOURNAMENT TOUGH, here.


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CHOP Experts Help Discover 11 Genes Newly Linked to Epilepsy
Published on Jan 23, 2019 in CHOP News
Division of Neurology
Children's Hospital of Philadelphia (CHOP) scientists participated in a large international research consortium to discover and analyze genetic influences on common forms of epilepsy. The findings may provide useful leads for future precision-medicine based therapies to help control seizures in children and adults.
Over 150 researchers from five continents contributed to the study by the International League Against Epilepsy Consortium on Complex Epilepsies (ILAE Consortium), which published its results Dec. 10, 2018, in Nature Communications.
The co-corresponding authors of the paper were Gianpero Cavellari, PhD, of the Royal College of Surgeons in Ireland, and Samuel F. Berkovic, MD, of the Epilepsy Research Centre at the University of Melbourne, Australia. The ILAE consortium performed a genome-wide association study (GWAS), comparing DNA from 15,000 patients with epilepsy to DNA from 30,000 healthy control subjects, to discover genetic locations linked to epilepsy risk. The DNA, from 24 different cohorts, came from Caucasian, Asian and African-American populations.
Hakon Hakonarson, MD, PhD Of the 24 collections of DNA, the largest group was the Philadelphia Cohort, led by CHOP. That cohort contributed DNA from 1,734 cases and 9,337 controls, drawn from Caucasian and African-American populations recruited by the Center for Applied Genomics (CAG) at CHOP. "This study illustrates the importance of multicenter consortia," said co-author Hakon Hakonarson, MD, PhD, Director of the CAG. "No individual cohort would provide enough samples with the statistical power to find associations such as you can obtain from this mega-analysis with tens of thousands of samples."
The genome-wide study revealed 16 significant loci, 11 of which had not previously been associated with epilepsy. These risk loci were common variants, and the majority were associated with genetic generalized epilepsy. These risk variants led the researchers to 21 candidate genes most likely to have a role in epilepsy. The study team identified various biological functions among those genes, such as regulating signal transmission between brain cells, metabolizing vitamin-B6, and controlling gene expression in the brain.
Ingo Helbig, MD The researchers found that 13 out of 24 currently licensed anti-epilepsy drugs target genes that were implicated in the current study. Notably, they identified 166 other known drugs that target some of their candidate genes, offering the potential to identify further targets for epilepsy treatments. "Studies at this scale allow us to better understand biological mechanisms that we are not aware of yet," said study co-author Ingo Helbig, MD, an attending physician and epilepsy genetics researcher in CHOP's Neurogenetics Program. "This will be important in finding pathways to target with new medications."
Epilepsy is one of the most common neurological disorders in children and adults, and CHOP is the regional leader in the Pennsylvania-New Jersey-Delaware area in treating children with epilepsy. "Up to 30 percent of children with epilepsy have difficult-to-treat seizures in which new strategies are urgently needed," said co-author Dennis Dlugos, MD, Director of CHOP's Pediatric Epilepsy Program. "It is our hope that this new knowledge will help researchers to develop targeted therapies to control seizures in the future. This is an area of active development."
Multiple grants, from the National Institutes of Health, several European research ministries, and private foundations, supported this research.
International League Against Epilepsy Consortium on Complex Epilepsies, "Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies," Nature Communications, published online Dec. 10, 2018.
Also see the posting by Helbig on this study on Beyond the Ion Channel, the official blog of the Genetics Commission of the International League Against Epilepsy.
Contact: The Children's Hospital of Philadelphia,
Why Choose CHOP Neurology
Learn more about our experience caring for children with complex neurological disorders and why you should consider us for your child's care.
Your Child's Neurology Appointment
Find information about scheduling appointments and consultations with the Division of Neurology at CHOP, including what to expect during your visit.
Division of Neurology Home
Professional Education Opportunities

redpajama_set_name: RedPajamaCommonCrawl


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How Long Are You Out?
Charlie Ban October 6, 2013 at 8:32am
Liz Greenlaw Photo: Steve Liaco
Everything is supposed to hurt during a marathon.
That's what Kate Volzer told herself in Philadelphia. Her legs were tired, back was sore, hip ached, but it all seemed like a temporary price to pay for the race she was running, the race of her life.
"My hip had been hurting for a month, but given the mileage I was running, it made sense something would be nagging," she said.
Kate Volzer. Photo: Dustin Whitlow
All of those miles paid off — she brought a 2:53 home to Arlington and enjoyed a few days off before she rejoined her GRC Racing teammates and Potomac Runners. But when she headed out the door to run again, she greeted a pain far worse than she had felt in the city of brotherly love.
Her physical therapist assured her it was a hamstring injury, at worst a tear, and it would heal with rest. A few doctors said that. For months, she followed the frustrating cycle of testing and resting, finding herself an unwitting initiate of a large distance running fraternity. The injured. Delta-Ow-Docta.
It starts with change. Something more than the body is ready to handle. Too much new mileage, too many work- outs, trusting too blindly in faddy running shoes. The averages say it's going to catch up with everyone eventually, everyone who pushes themselves to get faster. Sometimes a mild injury in one place can cause a form change that has musculoskeletal repercussions, like the plantar fascitis that help fell the erstwhile indestructible Michael Wardian.
He was absent from race results for the first time in more than 10 years in 2012. After thousands upon thousands of miles, his body didn't have an answer, and in August he was sidelined with five pelvic stress fractures. "The longest I've ever taken off was a day here or there when I'm traveling," he said. "It feels like something's missing."
Perhaps it's the 110 miles a week, or the ability to run the Houston Marathon the morning after competing in the U.S. Olympic Marathon Trials since he was already in town.
He attributes some of his injury to lack of sleep, because he and his wife take turns watching their son, Grant, who has recently suffered from seizures, which are under control now. With more rest and recovery, he hopes to be running in late October or early November. Though he targets the Kansas City North Face Endurance Challenge, he'll be happy to race the local Kinhaven 5k, which benefits his sons' school.
Dan Weiser Photo: Steve Laico
In the meantime, he bikes, including a one-day trip down Skyline Drive, to keep himself in shape. He's not exactly sitting on the couch watching television.
"Now I feel like I'm a real runner," he said. "Everyone else I know has dealt with an injury. I'm putting my time in. This is a blip on the radar."
"Every time I'd go out for a run, I'd cross my fingers and say 'please don't hurt, please don't hurt…'"
Doctors advised Volzer to find a new sport, take a corti- sone shot or elect for surgery, but it was too early for her to go under the knife. She took total rest for a few weeks and gave it another shot.
No dice. This time, her right hip joined in.
Her doctor suggested the body's symmetry was too uncanny to ignore. Further testing confirmed that her right labrum was also torn.
"I had already made the decision to go with surgery on the left hip, so by this point I figured I might as well take care of everything, rather than start up again and be forced to rehabilitate all over again."
So she was sliced up twice in August — left, then right, for each labrum to be repaired and irritating bone to be shaved down. She's looking at a late November return to running. In the meantime, though, she faces some existential questions.
"When you are at a certain level of running and then you can't run due to injury, you tend to feel like you are no longer an elite runner because you aren't technically running," she said. "So if you aren't the elite runner that you were and so badly want to be again, who are you? Who am I when I am injured? Am I still a runner?"
Liz Greenlaw's body has given her almost two years' worth of reasons to stop running.
Riding high on a string of great races in early 2011, she was looking ahead to that fall's Marine Corps Marathon. A stress fracture took her out, and she discovered she, like Volzer, had torn a labrum and would need surgery. She recovered from her fall 2011 procedure and gingerly ran again in the spring, gaining confidence in fun races, running under a family alias. She was primed for Marine Corps, and her fitness was coming along, until she felt her pelvis shift during a Capital Area Runners workout. She took time off and tried again to run for an hour in August. Afterward she knew she had to beg down to the 10k. Now, with another stress fracture diagnosed, she can just wait and start over.
But she will start over. She saw the course toward her potential with some great races and knew that wasn't "it." "I have total confidence I can get back to that," she said. "There's more running for me to do."
She keeps her age group award from the 2009 Marine Corps race framed above her bedroom door so she sees a reminder of better times whenever she walks out
"I remember how it felt to run healthy. I miss the adrenaline. I replay old races in my head, tough, challenging ones that ended up to be rewarding."
When Keith Kauffman works with injured runners, he keeps them focused on the present.
"There's a temptation to get caught in the past or the future," he said. "The regret, the what ifs. Athletes aren't the best at staying patient."
He's a sports psychologist with offices in Alexandria and Washington who also works with Catholic University's sport psychology research lab."Confidence is a tenuous thing when your body fails you," he said. "There's the fear of re-injury, concerns about lost fitness and the motivation to try and do too much when they get back."
He said many injured runners show depressive symptoms, in part because of their separation from their ex- ercise outlet, but more because they are missing out on what they enjoy, which includes social time for many. As a result, injuries can be harder on high school athletes. "Their teams are often their primary social group," Kaufman said. "Injured time is time away from their friends and less attention from their coach."
College student-athletes carry the added complication of losing a scholarship when mental burnout and extended injury lead them to walk away. Post-collegiate runners, though, face different concerns, especially as they age.
"I think knowing and being able to accept when a window has closed are potentially huge challenges for athletes, particularly when their identities have long been tied to their sport," he said. "This is why an injury that is career-threatening could be so devastating," because they have to face the limitations that their body puts on them. "They may be left with an unsettling feeling of, 'what now?'"
Runners aren't doomed to lives of injury and frustration, though. Through all the discipline and routine rehab, there's some hope. Dan Weiser took his first significant run in five months on Sept. 23, 2012. His poorly-aligned kneecaps deteriorated to the point where running was out of the question and climbing stairs or even hopping over curbs was a problem. He didn't deal with a draconian physician, though.
"My surgeon (John Klimkiewicz) never says 'don't run,' but always works with me to find ways to keep active," he said.
Weiser races a range of distances from 400 meters to 50k. Variety is not as enticing if he isn't wearing the rubber off of his shoes.
"Weights, stretching and swimming don't do it for me," he said, noting that biking also hurts his knees. "I miss the camaraderie of other runners."
As a coordinator for DC Capital Striders' evening Mall runs, he remains at the center of activity for the popular group runs. Now, he's on his way back.
His physical therapist, Alan Brodnick, had him try alternating walking and light running for a minute at at a time. He increased it slowly, held back when necessary.
"I felt great and wanted to keep running, especially as other runners passed me," he said. "I wanted to end the run feeling great, not in any pain, so that was my motivation for staying at five minutes."
Lindsay Wilkins couldn't do any cross training when she was hurt. In spring 2009, she tripped and tore the ham- string away from her right "sit bone." It wasn't something doctors normally saw in runners; rather, it was more of a hockey or water skiing injury. For six weeks, she was trapped in a hip cast. She could stand and lie down. No sitting. And certainly no Pacers racing team workouts. Traveling meant lying in her hatchback as her husband Brian drove her to doctor's appointments.
"It was a very difficult adjustment, but that surgery was the only way I'd be able to run competitively again," she said. Removing the cast at the end of six weeks was liberating, but the atrophy in her leg forced her to re-learn how to walk. Her subsequent stab at running was gradual.
"It was like I had never run a step in my life," she said. After more than a year, she felt something click. Unlike the well-documented fracturing of a bone or snap of a tendon, instead she felt like a runner again, the kind who was once 10 seconds away from winning a marathon two years prior. She was back, and it was time to see what "back" meant.
Her shot at the 2011 Chicago Marathon said it all. On a day much warmer than her 2008 Marine Corps runner up, she finished a mere minute off of her PR.
The whole process made her much more mentally tough.
"Feeling bad in a race is nothing compared to the misery of not being able to run," she said.
Volzer has been careful in the weeks following surgery. She's taking her rehab seriously and her cross training lightly."My personality is a little pessimistic," she said. "I'm always worrying about worst-case scenarios, and I've wondered at times what I will do if I start running again and the surgeries didn't fix anything."
She said even as the months piled on without an answer, she never gave up on running.
"I never lost hope, I got upset when I had a setback, but I never thought I wouldn't be running again someday." While she is waiting to resume her old life, Volzer can go to happy hours and meet up with friends after work instead of hitting the track. But that doesn't mean it's not on her mind. Or that she doesn't miss her GRC racing team and Potomac Runners training partners.
"I daydream about when I run again, all the time," she said. "I don't care how slow I'll be, I know I'll be smiling the whole time."
Not bad for a self-described pessimist.
This article originally appeared in the November/December 2012 issue of RunWashington.


text:
University of Southern California Digital Library > University of Southern California History Collection > Daily Trojan, Vol. 67, No. 77, February 21, 1975
Image / Daily Trojan, Vol. 67, No. 77, February 21, 1975
Title: Daily Trojan, Vol. 67, No. 77, February 21, 1975 Date: 1975-02-21 Collection: University of Southern California History Collection Owning Institution: University of Southern California Digital Library Source: Calisphere Date of access: January 21 2020 12:03 Permalink: https://calisphere.org/item/c5463ffc6933f22d6921aa170c584a16/
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Daily Trojan, Vol. 67, No. 77, February 21, 1975.
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University of Southern California [Contributing entity]
The Daily Trojan, 1912-
: Daily Trojan, Vol. 67, No. 77, February 21, 1975
: Southern California Daily Trojan, Vol. 21, No. 77, February 07, 1930
: Daily Trojan, Vol. 67, No. 96, March 20, 1975
: Daily Trojan, Vol. 67, No. 64, January 09, 1975
: Daily Trojan, Vol. 67, No. 113, April 23, 1975
: Daily Trojan, Vol. 67, No. 128, May 14, 1975
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CPI's Beverly Microwave Division presents VSX3630 GaN solid state power amplifiers (SSPAs) operating in the X-band (7.8 – 9.8 GHz). These high efficiency, high power, compact amplifiers are rugged, reliable, easy to maintain, and are designed for use as TWTA replacements for military radars.
The SSPAs feature air cooled GaN transistors that are combined into 900 W bricks, which are power-combined using waveguide combiners for higher power transmitters. The GaN transistors provide high gain, high efficiency, and excellent pulse fidelity resulting in exceptional AM/PM, phase-noise, and spectral regrowth performance.
Download the datasheet for more information regarding the X-band GaN SSPAs.


Cutie Pai did a one hour stage at Comic Market on December 30, 2003. They wore their "new" waitress outfits (orange, green, red) and sang almost all of their songs.
I was very sick this day, but I carried my heavy camera bag with two cameras and the video camera. But they announced right before the start of the stage that photos and videos weren't allowed.


I was always a water baby. I was born on a rainy Atlantic island and then moved to the warmer, drier California a few years later. I spent my first years swimming, diving and spending as much time submerged as I possibly could. I didn't think to bring a camera into my favorite hobby until a few years ago when I realized how much I wanted to capture what I see in diving and swimming. There is so much that happens in the few meters above and below the surface of the water that many people never get to see. My goal in photography has always been to capture those images that are ever-present in my head after I get out of the water so I can share them with others. I am endlessly enthralled by the relationship between water and light and the water and the humans or animals that spend their time in it.
When I am in the water, whether it is diving, or swimming in the lineup at one of the surf breaks near my home, as a woman I have always been the minority. There are more and more water women every day, but presently, and for the foreseeable future, it is very much a male-dominated realm. I don't let this bother me because when I'm in the water, I feel like I'm in my own world, focused on what I'm trying to capture. I have had some men in the lineup act with surprise that I'm out there swimming around, especially in bigger surf. I've been asked if I need help, or if I know how heavy the break is. Usually, I just smile and say I'm fine and laugh it off. I know my own limits, and I feel confident in the waves that I swim in and the breaks that I shoot.
One of my greatest assets in the water is how interested people are in the specific camera that I use. I shoot with a Nikonos III, a 35mm camera, that is itself entirely waterproof with no need for bulky housing. It was first sold in 1975 and it definitely looks its age. People are naturally drawn to ask about my camera and start a conversation with me about it in the water. I hope that people's intrigue in the Nikonos and the images I produce is what creates an interest in my photography, and not the fact that I am a woman swimming with a camera.


Why King's Match-3 Games Are So Popular? Статья - Бесплатные игры Кэжуал!
Оценить эту Статью King is a game company known for its widely popular match-3 games, and that's not without reason. Here are some ways that King is successful in creating match-3 games that gain massive players.


Unlike the hair on your head, beard hair tends to have a coarser, often thicker texture, which requires more upkeep than just a quick shampoo and rinse. Even if you don't use conditioner in your hair, your beard will benefit from routine application of a moisturising conditioner—either one you rinse out in the shower or a leave-in formula (the latter tend to be lighter-weight).
You can use a regular hair conditioner (chemist brands are fine) or check out the beard conditioners offered by various men's grooming brands. Before you buy, be aware that finding the conditioner that's right for you can take some experimentation; you might need to try a few before you hit the sweet spot.


Stress is caused by our reactions to the situations and circumstances in which we find ourselves. It is something that we give shape and form to. It is not a new thing medicine links stress responses to man's basic instinct for "Fight or Flight".
When we are stressed our systems trigger hormones to be released, which send the body into a state of alertness in preparation for action. Our digestion is depressed, as food processing is no longer the body's priority, we become pale as our body directs the blood flow away from our skin towards towards the heart brain and muscles. The muscles tighten and tense in preparation for action.
Stressors in our lives are many and various. In the work place expectations are that people must do more and more just to 'keep their heads above water'. Computers have taken out the slog out of mundane tasks. Data processing has speeded up the creation of reports and printouts. They arrive thick and fast, but the time it takes to read, assess and understand these documents has remained constant and has not speeded up. On the back of improved communications and diminishing donkey work thanks to computers and technological inovations, workers are required to take on more and more.
If we buy in to the expectations of keeping up, we are buying into a deficit model. Feelings of being swamped and inadequate proliferate and the ever more elastic job descriptions encroach upon our private lives. Time we should be spending to relax, to do something for ourselves, to be with our loved ones sometimes seems little better than an illusion to torment ourselves with. How many times do you hear people say "If I had the time, I would..." then up pop two other familiar stress factors, guilt and dissatisfaction because the time and capability to do what they want in their life eludes them.
People try to balance their need to work and the demands of ever more elastic working hours. Some succeed and seem to thrive on stress, others find it hard to find free time - another source of stress is then triggered because the individuals are not attending to their own needs or to those of their family and friends, which engenders? Yes you've guessed it- more stress. Some founder and suffer from a lack of balance in their lives. The inability to perform this intricate balancing act results in stress, which is all too often refelected in an inbalance in both the physical and mental health of the individual.
Copyright ©1999-2008 Healthutopia.com. All rights reserved.


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redpajama_set_name: RedPajamaGithub


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, real name , is a Japanese manga artist and the third president of animation production company Tatsunoko Pro.

History
Ippei Kuri was born Toyoharu Yoshida on January 1, 1940, in Kyoto. As a child, he read comics such as Superman that were discarded by American troops stationed in Japan during the Allied occupation following World War II. Kuri stated he wanted to make a manga like that when he grew up. This had an influence on his manga and anime character design style. He attended Kyoto Municipal Rakuyō High School (now Kyoto Municipal Rakuyō Technical High School), but left in 1958 before graduating in order to join his older brother Kenji in Tokyo to work as a manga artist.

He worked as an assistant for his older brother Tatsuo, who was already a successful illustrator and manga artist. Kuri made his manga debut in 1959 with , published as an akahon and in the Japanese magazine Z-Boy from Shueisha. From 1960–1961, Kuri worked on  with creator Minoru Kume. In 1962, Kuri co-founded the animation production company Tatsunoko Productions with his brothers Kenji and Tatsuo. Since then, he has worked in many different roles, including as an animation producer, in planning and design, and as a director.

Kuri was appointed the managing director of Tatsunoko Pro subsidiary Anime Friend in 1977. In 1987, due to the retirement of his brother Kenji, Kuri became the president of Tatsunoko Pro. Anime Friend was dissolved in 1990. Tatsunoko Pro became a subsidiary of the major toy manufacturer Takara on July 1, 2005, and Kuri stepped down as president at that time. The Yoshida brothers' involvement in the company has since been very limited.

At the 10th Animation Kobe event in October 2005, Kuri was awarded the special award for lifetime contributions to anime as a general producer at Tatsunoko Pro. Kuri is currently a guest professor at the Kyoto University of Arts and Crafts.

Works
Listed in chronological order.

Manga
  with Minoru Kume (1960-1961)
  (1962-1964, Weekly Shōnen Sunday, Shueisha)
 Judo Boy (writer, 1961–1962, Shōnen Book, Shueisha)
  (1967-1968, Weekly Shonen Sunday, Shueisha)
 Judo Boy (writer, 1968–1969, Weekly Shōnen Sunday and Weekly Shōnen Jump, Shueisha)

 Messenger of Allah (Bōken-Ō, Akita Shoten)

Anime
 Space Ace (1965-1966, planning, script, executive producer, character designer, animation director)
 Speed Racer (1967-1968, executive producer)
 Judo Boy (1969, creator, series director, executive producer)
 The Adventures of Hutch the Honeybee (1970–71, executive producer, series director)
  (1971, series director, executive producer, animation director, key animator)
 Pinocchio: The Series (1972-1973, executive producer)
 Science Ninja Team Gatchaman (1972-1974, producer)
 Demetan Croaker, The Boy Frog (1973, producer)
 Casshan (1973-1974, producer)
 New Honeybee Hutch (1974, producer)
 Tekkaman: The Space Knight (1975, producer, executive producer)
 Time Bokan (1975-1976, planning, producer)
 Gowappa 5 Gōdam (1976, executive producer)
 Paul's Miraculous Adventure (1976-1977, producer)
 Temple the Balloonist (1977-1978, executive producer)
 Yatterman (1977-1979, planning, producer)
 Gatchaman II (1978-1979, producer, character designer)
 Gatchaman Fighter (1979-1980, planning, producer)
 Zenderman (1979-1980, planning, producer)
 Gordian Warrior (1979-1981, planning, character designer)
 Muteking, The Dashing Warrior (1980-1981, planning, producer, character designer)
 Rescueman (1980-1981, planning, producer)
 Dash Kappei (1981-1982, planning)
 Golden Warrior Gold Lightan (1981-1982, planning, character design)
 Yattodetaman (1981-1982, planning, producer)
 Gyakuten! Ippatsuman (1982-1983, planning, producer)
 Itadakiman (1983, planning, producer)
 Mirai Keisatsu Urashiman (1983, planning)
  (1985-1986, planning)
 Doteraman (1986-1987, development)
 Zillion (1987, producer)
 Oraa Guzura Dado (1987-1988, planning)
 The Adventures of Hutch the Honeybee (1989-1990, producer, character design)
 Legend of Heavenly Sphere Shurato (1989-1990, producer)
 Kyatto Ninden Teyandee (1990-1991, general production manager)
 Robin Hood (1990-1992, animation producer)
 Tekkaman Blade (1992-1993, producer)
 Casshan: Robot Hunter (1993, executive producer)
 Time Bokan: Royal Revival (1993-1994, planning, producer)
 The Story of Cinderella (1996, producer)
 Speed Racer X (1997, character development, art director, theme song lyrics, etc.)
 Yobarete Tobedete! Akubi-chan (2001-2002, planning, producer)

Books
  (November 2004, Kodansha, )

References

External links
Ippei Kuri biography on Lambiek

1940 births
Anime directors
Japanese anime producers
Japanese animated film directors
Japanese animated film producers
Living people
Manga artists
People from Kyoto
Tatsunoko Production people

redpajama_set_name: RedPajamaWikipedia


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Album ReviewsReviews
Album Review: MOTÖRHEAD – Bad Magic
Jake KüssmaulOctober 8, 2015
MOTÖRHEAD – Bad Magic
Never too punk for metalheads or too metal for punks, Motorhead's genuine craving for excess has astoundingly pushed their survival rate through an impressive four decades. They have retained their stance as a power trio, each member a substantial contributor. On August 28, the band released Bad Magic, their 22nd album to date. After this long an existence, and despite myriad evolving tastes that have noticeably hindered the space for rock music, this album smashes the odds.
[columns] [column size="1/3″]
MOTÖRHEAD - Bad Magic
[/column] [column size="2/3″]
Artist: MOTÖRHEAD
Album Title:Bad Magic
Release Date: 28 August, 2015
Playing Time: 00:42:48
Label:UDR Music
[list style="music"] [li]Victory or Die[/li] [li]Thunder & Lightning[/li] [li]Fire Storm Hotel[/li] [li]Shoot Out All of Your Lights[/li] [li]The Devil[/li] [li]Electricity[/li] [li]Evil Eye[/li] [li]Teach Them How to Bleed[/li] [li]Till the End[/li] [li]Tell Me Who to Kill[/li] [li]Choking on Your Screams[/li] [li]When the Sky Comes Looking for You[/li] [li]Sympathy for the Devil (The Rolling Stones cover)[/li] [/list]
[/column] [/columns]
Right when I heard the opener, "Victory or Die," I immediately recalled what I love about the band, and that is their ability to trust their gut, without being discouraged by criticism. True to their roots, the song emits an incredibly pronounced garage aesthetic. The moment the band fire up their instruments, it's clear that they aimed to give the album a faultless live atmosphere. Guitarist Phil Campbell's punk-tinged riffing charges unapologetically throughout, and his razor sharp lead transitions are equally forceful. Lemmy's vocals may have endured countless bouts of varying abuse, but his lyrics always carry the same sincerity. The contrasts of the two choruses—one dealing with a fantastical sighting, and the other a dose of tough love for a wartime reality—ultimately share an important goal akin to Motorhead's vision. That is, to maintain a mental "zone" on the path toward personal success, amidst the palpitation-inducing bizarreness of the world.
On the second track, "Thunder & Lighting," the chugging and thickness of the bass line really shine through. While exhibiting an extremely similar feel to the classic "Ace of Spades" in tonality as well as key, its placement in the instrumentation is especially fitting to potentially draw in new fans. Lemmy fondly acknowledges the positive jolt obtained through live performance, as well as the bleak and unpredictable happenings of the road. While such a subject matter might present itself as cliché and rather dated, the manner in which Lemmy portrays it is both honest and concise ("All of your dreams can really come true/All of your nightmares will be waiting there too"). When pursued, that lifestyle surely causes a blur between danger and excitement, leaving only the beholder to determine its own destiny.
Much like the previous song, "Thunder & Lightning" reinforces the value, as well as the healthy challenges that result from taking action. The third track, "Firestorm Hotel," contains nuances of a previous Motorhead era, featuring stronger hook structures and chord progressions. Its theme centers on stealthily steering clear of hazardous insanity, in an environment full of smog-filled disarray. The harmonies during the chorus phases create an interesting layer of additional grit that accentuates Lemmy's natural rasp. At the 1:45 mark, a small bass solo keeps the energy intact, eventually building to a popping guitar solo, prompted by the unremorseful instruction, "Burn!" It could suggest the hotel is being destroyed, providing listeners insight into the band's creative process, and keeping a solid focus on being melodically stimulating. From the ending phase, it is implied that even though the evil is momentarily stopped, it will always find a way to thrive again.
Beginning with the fourth track, "Shoot out All of Your Lights," the album shifts to a more metal-oriented sound. The double-bass drum foundation is sufficiently evident in signaling this change, and what follows is a thrash-laden speed and intensity. At the same time, there is a newfound attack-based assertiveness that defines both the instrumentation and lyrical theme. The song plays out more or less like an interrogation act, catching sketchy suspects and demanding answers. The call-and-response shouting of 'fight' and 'die' in the chorus also really worked to the song's advantage, especially when accentuated by the punchy riffs. This ultimate mutation in attitude is elevated by "The Devil", which sports a Black Sabbath-inspired vibe, ideal for evoking the dominance of one's faulty behavior. It is then expanded upon in "Evil Eye," stressing the extent to which the "rebel in solitude" way of life could twist one's identity. As this song proceeds, Lemmy's voice fluctuates between normal —an angel providing guidance, and a menacing growl—a devil counteracting with a crippling curse. Both are perfect representations of a conscience at war, with one side made to sternly warn against danger, while the other exudes a blunt and snide harshness.
Another stylistic shift occurs in the ninth track, the retrospective ballad "Till the End." Here, Lemmy's stationary vocals sound wholly refreshing, and are a welcome change of pace from the dominating rockers. In this song, he deviates from the chaos, instead reflecting on how putting himself first has allowed him to move forward. Although this way of life can prove difficult for anyone to live by, hearing those anecdotes from the man himself feels like receiving advice from a mentor. Just by the matter-of-fact manner in his voice, I can truly get a sense of how his choosing to live the high-life has essentially grounded him. This song is actually the first I've heard of Motorhead's to feature clean guitars, and even the bass' distorted quality works solidly with its grounded mood. If there's anything else the band can effectively stamp their identity onto, it is, without a doubt, cover songs. Having long been a standard since their initial years, the band succeeds yet again with their rendition of Rolling Stones' "Sympathy for the Devil". The samba-meets-metal groove translates naturally with the Motorhead sound, and the lead guitar stands prominent during the bash-it-out solo breaks. As the closer, it's an appropriate thematic tie-in, and provides a bit of nostalgia, which is always a plus.
Overall, Bad Magic is a mature, thought-provoking concept with a ruthless and youthful soul. Its extensive emphasis on rawness, as well as its progressive detailing of harsh road realities is executed very intelligently. There's a distinct tone of clashing spirituality that, whether intentional or not, gives the album a tasteful balance of theme and style. Along the way, there are allusions to previous eras of the band that instill an element of fun (and, to extent, surprise) to the album's flow. Regardless what longtime fans may say otherwise, it's understood that Motorhead always deliver gritty, unabashed rock n' roll whenever necessary, and prove that they are still capable of putting up a worthy fight.
[9/10] [separator style="space" /] [blog type="alt" tags="motorhead-photos" heading="Motorhead – The Warfield – San Francisco, CA – August 24, 2015″ heading_type="block" /] [separator style="space" /]
Jake Küssmaul
Jake is a musician and writer from the hamlet of Hawthorne, NY. Despite having mild cerebral palsy, he continues to break barriers, developing solid connections and lasting friendships with bands around the world.
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Festival Review: BRUTAL ASSAULT 2016 at Fortress Josefov
Album Review: DEAD TO ME – I Wanna Die In Los Angeles – EP


Track: 30 COOL AND SIMPLE GIFT PACKAGING IDEAS (Gift Christmas ideas money giving).
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text:
1 Actor/Actress / A
by follers · August 12, 2014
Aiello in 2009, photo by Prphotos
Birth Name: Daniel Louis Aiello, Jr.
Date of Death: December 12, 2019
Place of Death: New Jersey, U.S.
Ethnicity: Italian
Danny Aiello was an American actor. His roles included Do the Right Thing, The Godfather Part II, The Front, Hide in Plain Sight, Once Upon a Time in America, The Purple Rose of Cairo, Moonstruck, Harlem Nights, Jacob's Ladder, Hudson Hawk, Ruby, The Cemetery Club, Léon: The Professional, 2 Days in the Valley, The Last Don, Dinner Rush, and Lucky Number Slevin.
Danny was the son of Frances (Pietriacoca/Pietrocova) and Daniel Louis Aiello. His parents were both of Italian descent. His father had roots in Naples, Campania. His mother's family was from Naples and Sorrento, the latter of which overlooks the Bay of Naples. His nephew is play-by-play broadcaster Michael Kay.
Danny was married to Sandy Cohen, until his death, with whom he had four children, including actor Rick Aiello and stuntperson Danny Aiello III.
Danny's paternal grandfather was Guiseppe/Joseph Aiello (the son of Amiello/Aniello Aiello and Rosa Polio/Paula). Guiseppe was born in Sorrento, Napoli, Campania, Italy.
Danny's paternal grandmother was Helena/Elena/Elana Lily Yaccarino/Jaccalino/Iaccarino (the daughter of Mariano Yaccarino/Jaccalino and Giovannina/Jennie Esposito). Helena was born in Sorrento.
Danny's maternal grandfather was named Raffaele Pietriacoca/Pietrocova/Pietriacono. Raffaele was born in Italy.
Danny's maternal grandmother was named Rosa Corson. Rosa was born in New York, of Italian descent.
Sources: Genealogy of Danny Aiello – https://www.geni.com
Danny's parents on the 1930 U.S. Census – https://www.familysearch.org
Jason Biggs
Laura Nyro
Maria Brink
Tags: CampanianItalianNeapolitan
he stated in his autobiography "I Only Know Who I Am When I Am Somebody Else":
"My mother's family, the Pietrocovas, came from the Naples and Sorrento areas of Italy"
I think he might have said that he might have Jewish ancestors in the 1500s or something…
Is there a url?
real_list says:
https://www.italian-family-history.com/jewish/_Sicilia.html#Surnames
https://thecjn.ca/news/canada/daughters-calabria-describe-jewish-journey/
Rochelle Humes
Gilbert Gottfried
Erik Estrada
Raviv Ullman
Zhang Ziyi
Tony Danza


text:
Railways to exploit LTT land to fund CST makeover
Railway authorities are expecting revenue of around Rs.600 crore through commercial exploitation of around 20 acres of open land at Lokmanya Tilak Terminus (LTT).
Sources said this was the Railways' Plan B in its effort to hasten the ambitious project of developing CST as a world-class station that has been stuck in a heritage tangle for the past three years.
Although it was announced in the railway budget of 2009-10, the development of CST, tagged as a world heritage site, as a world-class station, failed to take off as UNESCO turned down the Railways' plea to rationalise the buffer zone around CST. A few months ago, it had asked railway authorities to carry out a heritage impact study. Concerned about the future of the project, authorities started exploring other avenues to fund the project.
The Railways had first planned commercial development of its land at Carnac Bunder, to generate revenue for the CST project. Now, authorities are mulling the commercial exploitation of land at LTT. At Carnac Bunder, authorities were planning budget hotels, malls, multi-storey parking and food courts. A top CR official said, "Our estimate is that through commercial development at LTT, we can generate at least Rs600 crore in revenue."
The 'Railway Land Development Authority' (RLDA), the apex body that decides about commercial exploitation of railway land, is now going to study the actual valuation of land through consultants. Pankaj Jain, vice chairman of RLDA, was in town recently to explore the possibility of commercial development of land at LTT, Thane and Haji Bunder.
Jain inspected Thane station and discussed with CR general manager, Subodh Jain, various issues related to the commercial development of railway land.
"At Thane station we have planned to develop a multi-functional station with various passenger amenities such as dormitories, waiting rooms and food courts," Subodh Jain said.
Subodh Jain also said they had asked RLDA to appoint a consultant to study what could be done to develop railway land at Haji Bunder, where the Railways have another huge piece of land.
http://www.hindustantimes.com/India-news/Mumbai/Railways-to-exploit-LTT-land-to-fund-CST-makeover/Article1-951181.aspx
on November 3, 2012 at 1:39 pm Leave a Comment
Tags: commercial development of land, ommercial exploitation of railway land, passenger amenities, Railway Budget, Railway Land Development Authority, Railway Land Development Authority (RLDA), RLDA, world-class station
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Adventurous activities, led by experienced professional guides, delivering a positive, safe, learning experience.
Memorable and challenging 2-5 day treks across the Pyrenees mountains, following the routes used by "evaders" during WW2.
Adventurous outdoor activities, cultural experiences and visitor attractions, set in the Ariege, south west France.


text:
Carl Dahlhaus (10 June 1928 – 13 March 1989) was a German musicologist who was among the leading postwar musicologists of the mid to late 20th-century. A prolific scholar, he had broad interests though his research focused on 19th- and 20th-century classical music, both areas in which he made significant advancements. However, he remains best known in the English-speaking world for his writings on Wagner. Dahlhaus wrote on many other composers, including Josquin, Gesualdo, Bach and Schoenberg.

He spent the bulk of his career as head of the Berlin Institute of Technology's musicology department, which he raised to an international standard. Dahlhaus pioneered the development of numerous musicological fields, particularly the aesthetics of music, which he raised to a central status. Active as a historian, analyst, editor and organizer, he was massively influential and his work has since incited considerable discussion and debate.

Life and career
Dahlhaus was born in Hanover on 10 June 1928. The Second World War interrupted his early education; he served on the front and as an anti-aircraft auxiliary. He completed school exams through a special program designed for those engaged in combat. After a brief stint studying law, Dahlhaus first engaged in musicology from 1947 to 1952, studying with Wilibald Gurlitt at the University of Freiburg and Rudolf Gerber at the University of Göttingen. His 1953 dissertation at the latter concerned the masses of Josquin des Prez. Instead of seeking an academic career, he engaged in the theatre and journalism worlds. Having begun as a student, he worked as dramaturg for the Deutsches Theater in Göttingen from 1950 to 1958; Bertolt Brecht had encouraged him to take the post. From 1960 to 1962 he worked as musical editor for the Stuttgarter Zeitung newspaper, acting as a relentless promoter of the Darmstadt school.

His first academic position came in 1962, when he served as a research assistant at the University of Kiel until 1966. That year he completed his a work for his Habilitation, Untersuchungen über die Entstehung der harmonischen Tonalität (Studies on the Origin of Harmonic Tonality), published in 1968. The work was a seminal study on the origins of tonality, reaching back to the Renaissance and Baroque periods. Originally in German, Robert Gjerdingen has published a translated version in 1990 through the Princeton University Press. After working at Saarland University for less than a year, he was hired in 1967 to succeed Hans Heinz Stuckenschmidt as the head of the Berlin Institute of Technology's musicology department. He would remain there until his death, gradually expanding and developing the university's previously minuscule musicology program to one of international renown. Though many universities offered him positions throughout his tenure, he rejected them all; the only exception was the two semesters he spent as a visiting Professor at Princeton University.

Dahlhaus was honored with the Order of Merit of the Federal Republic of Germany (Grand Cross with Star), a Blue Max, and accepted into the German Academy. In 1987, he was awarded the Frankfurter Musikpreis.

After being ill for some time—a sickness he mostly kept private from his colleagues—he died in Berlin on 13 March 1989, from kidney failure. He had been working on a succinct history of Western music in English at the time, which was left unfinished.

Musicological scholarship
Dahlhaus wrote 25 books, more than 400 articles, and contributed to 150 other works on a wide range of subjects. The majority of these were on the history of Western music and particularly that of the 19th century, i.e. Romantic music. Composers whose music he wrote on include Josquin, Gesualdo, Bach and Schoenberg. 19th- and 20th-century classical music were also regular topics. All of his major works were written in German; the history of Western music he left incomplete would have been his first English publication.

He was very interested in the work of Richard Wagner and remains best known English-speaking world for his writings on Wagner. Other topics he regularly engaged in include music theory, the aesthetics of music, and the prehistory of "new music".

Legacy
Towards the end of his life, Dahlhaus was the most eminent and influential musicologist of his generation, with his works continuing to incite considerable discourse, discussion and controversy. He expressed himself not only as a musicologist, but as a historian, analyst, editor and organizer. His achievements include encouraging new interest in 19th-century music, particularly through his 1989 Nineteenth-Century Music publication.

His diverse interests allowed legitimized various musicological subfields, and broadened the discipline considerably. J. Bradford Robinson gives "systematic musicology, institutional history [and] salon music" as examples of newly accepted topics due to his influence. He was a principal proponent in raising aesthetics as a topic in the forefront of musicology. In addition, he helped establish a coherent narrative for 20th-century classical music.

Selected bibliography
 Dahlhaus, Carl. 1979. Richard Wagner's Music Dramas. Translated by Mary Whittall. Cambridge & New York: Cambridge University Press.
 ———. 1980. Between Romanticism and Modernism: Four Studies in the Music of the Later Nineteenth Century. Translated by Mary Whittall. Berkeley: University of California Press.
 ———. 1982. Esthetics of music. Translated by William W. Austin. Cambridge & New York: Cambridge University Press.
 ———. 1983a. Analysis and Value Judgement. Translated from the German by Siegmund Levarie. New York: Pendragon Press.
 ———. 1983b. Foundations of Music History. Translated by J. B. Robinson. Cambridge & New York: Cambridge University Press.
 ———. 1985. Realism in nineteenth-century music. Translated by Mary Whittall. Cambridge & New York: Cambridge University Press.
 ———. 1987. Schoenberg and the New Music: Essays. Translated by Derrick Puffett and Alfred Clayton. Cambridge & New York: Cambridge University Press.
 ———. 1989. Nineteenth-Century Music. English translation by J. Bradford Robinson. Berkeley: University of California Press.
 ———. 1989. The Idea of Absolute Music. Translated by Roger Lustig. Chicago: University of Chicago Press.
 ———. 1990. Studies on the Origin of Harmonic Tonality. Translated by Robert O. Gjerdingen. Princeton, NJ : Princeton University Press.
 ———. 1991. Ludwig van Beethoven: Approaches to His Music. Translated by Mary Whittall. Oxford: Clarendon Press; New York: Oxford University Press.
 Deathridge, John, and  Carl Dahlhaus. 1984. The New Grove Wagner. New York: W. W. Norton.
 Ruth Katz and Carl Dahlhaus (1987-1991): Contemplating Music (Sources in the aesthetic of music, selected, edited, annotated and introduced, with original translations, in four volumes), New York: Pendragon Press. Vol. I Substance (1987); Vol. II  Import (1989); Vol. III Essence (1991); Vol. IV Community of Discourse'' (1991).

References

Sources

Further reading

Musicologists from Berlin
1928 births
1989 deaths
Writers from Hanover
German music historians
Beethoven scholars
Knights Commander of the Order of Merit of the Federal Republic of Germany
Recipients of the Pour le Mérite (civil class)
20th-century German historians
20th-century German composers
Members of the German Academy for Language and Literature
20th-century German musicologists
Wagner scholars
Josquin scholars
Academic staff of the Technical University of Berlin