text:
" admonition *." The Jewish Church being removed, the Christian Church stands in its place, and is to apply to herself the same admonitions. And thus, in the present instance, the seven Churches of Asia being sunk in Mahometan superstition, their " lamp-bearer removed," all the Christian Churches inherit the advice given, the threatenings denounced, the blessings pro. mised by their divine Lord.
Ver. 4. Grace be unto you, and peace, &c.] The Salutation in this epistle resembles those in other epistles of the New Testament; in almost all of which the inspired writer intreats "grace and peace from God the Father, " and our Lord Jesus Christ." But the Godhead is here described with some additional expressions, not unscriptural, but presented in a new form, being such as naturally arose in the mind of the Apostle from the impression of the vision which he had then seen, and was proceeding to relate. Full of the images lately presented before him, he recurs to them even in this his introduction, and instead of saying, in the calm expression which otherwise be might have used, " Grace from "God the Father," &c. he says, " Grace from him " that was," &c. using the very forms of speech in which he had heard the Divine attributes described in the vision.
The description of God the Father, occurs under the same expression, ch. iv. 8, from which place it is evidently taken; and is consonant to the great I AM of Exod. jii. 14. The description of God the Son is in like manner taken from the vision. He calls himself + " the faithful and true witness." He is so styled prophetically by Isaiah I; such he was eminently in the last scene of his earthly life, when" before Pilate
1 Cor. x. 6-11. + Ch. iii. 14. Ch. lv. 4.
os he'
"he witnessed a good confession*." Our Lord calls himself also in the same passage, "the beginning of "the creation of God." He is styled by Saint Pault, "the first-born of every creature," and I "the first " fruits from the dead." But here he is also intitled " The Ruler of the kings of the earth." But such is the prophetic character of the Messiah in Scripture, and such he is eminently shewn to be in the sequel of this prophecy $.
But in this salutation, grace and peace descend, by the prayers of the pious writer, not only from God the Father and the Son, but also from a third Power ; " from the seven spirits which are before the " throne." To understand this expression, we must refer to chap. iv. 5. where, in the glorious representation of the Deity, are exhibited " seven lamps of " fire burning before him, which are the seven spirits " of God. But in chapter iii. 1. God the Son describes himself as " having the seven spirits of God;" and when || he appears under the emblem of the Lamb, he is described as having " seven eyes, which are the "seden spirits of God, sent forth into all the earth." But what can we account this universal, holy Spirit of God, proceeding from the Father and the Son, to be, but that which, in the plainer language of divine Scripture is called the Holy Ghost? The comment of Vene
* 1 Tim. vi. 13. mom xead my opodorysar, the noble, honourable, excel. lent confession. The primitive Christians, who suffered martyrdom in the Gallic churches, considered the title of Martyr as appropriate to their Lord, and were unwilling to take it to themselves. Euseb. Hist. Eccl. lib. v. c, 2. + Col. i. 15.
I i Cor. xv. 23. $ Ch. xviii. 14. xix. 16.
ll Ch. v. 6.
rable
rable Bede on this passage appears forcible and just, "Unum spiritum dicit septiformem, quæ est perfec;" tio et plenitudo*.
So that this salutation, divested of its prophetical form, and of that imagery which had been derived to it from the scenery of the vision, will be found equivalent to the epistolary and plainer language of Saint Paul, "The Grace of our Lord Jesus Christ, ." and the love of God, and the fellowship of the " Holy Ghost be with you t."
But why, in this passage, is the general order of Scripture inverted? Why is the Holy Spirit mentioned before the Son? This may in part be accounted for, from the impression remaining upon the imagination of the writer, after he had seen the vision. For in chap. iv. 5, where the symbol of the seven spirits was seen, it had appeared before the throne, closely connected with the glory of the Father, and previously to the entrance of the Son, under the emblem of the Lamb. Another reason may be, that the character and description of the Son is reserved separately for the last, there to be longer dwelt upon; because he appears throughout the vision to be the prime agent, and the grand object of the whole prophecy ; he who, alone of the persons in the Godhead, has taken our human nature upon him, and visibly fought our battles against the common enemy. He is de
* " The one Holy Spirit is here described as sevenfold, by which is " intimated in prophetic language fulness and perfection."— The most ancient commentators, as reported or followed by Andreas Cæsariensis, by Arethas, Primasius, and Victorinus, understood by the seven spirits and seven lamps of fire (ch. iv. 5,) the Holy Spirit, or the seven Charismata thereof, mentioned in Isaiah xi. 2. + 2 Cor. xiii. 13.
scribed
scribed to us here, ift, As in his suffering state ; when, having taken the lowly form of a servant, by his sufferings he bare witness to the truth. 2dly, As the first fruits from the grave *; when, triumphing over sin and death, he obtained the victory for his faithful followers. 3dly, As King of kingst; when, fulfilling all the prophecies which predict the Messiah, he shall reduce all nations under his easy yoke, utterly subduing all worldly tyranny and usurped dominion. The two first of these offices and characters he hath already fulfilled; the first during his earthly life, the second at his resurrection; the last remains to be completed ; and is peculiarly the subject of the prophecies in this book I.
Ver. 6. The Doxology, or Glorification, which in other of the sacred epistles is no unusual sequel to the Salutation, comes next in order ; but is more especially addressed to the Son, as the grand agent in the vision. The love of Christ towards mankind, and the ablution of their sins by his precious blood, are topics celebrated universally in the New Testament; but no
• 1 Cor. xv. 20. + 1 Tim. vị. 15.
For the change of case, which the Greek reader will remark in this passage, - 4750 'Inox ó macęlus," let him consult Grotius on Mark vi. 40. who points out such construction, not only in the scriptural, but also in the classical writers; but this grammatical inaccuracy is more appropriate to the Hebrew-Greeks. And the oceurrence of such in the Apocalypse, is so far from militating, as hath been re. presented, against the authenticity of the work, that it tends to establish its authority, by placing it upon the same footing in this respect with other books of the sacred canon. For, ungrammatical Greek, or at least Greek of impure idiom, will be found in most of them, though perhaps not so abundant as in the Apocalypse.
where more copiously than in the writings of Saint John. That he hath prepared for his faithful servants a kingdom, and appointed them priests unto God, though more immediately connected with the subject of this prophecy, are not novel ideas, but purely scriptural. A kingdom is proposed for the servants of Christ*, they are to reign with himt. And in Exod. xix. 5, God promises to Israel that by obedience, they shall become "a kingdom of priests, à " peculiar treasure unto God above all nations, a holy "nationt." In Isaiah, ch. lxi. 6, this promise is extended to the Christian times and to the converted Gentiles, whom Saint Peter also calls an holy priesthood, a royal priesthood S; in which latter expression, as in the words of Moses, the two ideas of kings and of priests are brought together. In the Septuagint the words of Moses are rendered by Βασιλειον Ιηράβευμα, the very expression of Saint Peter, which is also to be found in some MSS. of the Apocalypse; but the true text seems to be given by Dr. Griesbach from the Alexandrine and other ancient MSS. confirmed by the readings in the Fathers whom he has quoted|l.
Ver.7. In this verse the prophet, enraptured with his subject, passes from the glorification of Christ, which he had delivered in the form of a prayer, to the description of the awful event, when (as foretold in Scripture) he shall come in the clouds of heaven, in
* Mat. xxv. 34. Luke xii. 32.
+ 2 Tim. ii. 12. 1 Cor. iv. 8. vi. 2, 9.
See also Deut. xv. 6. xxvi. 19. xxviii. 1. § 1 Pet. ii. 5, 9.
ll To which we may add, that the manuscript used by Tertullian in the second century, seems to have presented the same reading. Tertullian. de Monogam. cap. 12.

redpajama_set_name: RedPajamaCommonCrawl


text:
Beauden Barrett's younger brother Jordie set to star in U20 World Championship
Ahead of next month's Under 20 World Championship in Manchester, title holders New Zealand fired a...
Double World Cup winner Ben Franks on life after rugby and his time in the Premiership
Former All Black and current London Irish prop Ben Franks has experienced success at multiple levels,...
Evergreen George Smith still going strong at 35 - Aviva Premiership Player of the Month
George Smith is regarded as one of the best flankers to have ever played the game,...
True Grit: The David Pocock Story - Part 2
Last week we shared part one of this fascinating David Pocock documentary that gives us a...
To most rugby fans, David Pocock is that Wallaby who cannot be moved off the ball....
Tuesday Oct 13, 2015
Ma'a Nonu reflects on reaching 100 Test Caps, and how Tana Umaga was his idol
Ma'a Nonu played his 100th Test against Tonga this past weekend, scoring the seventh and final...
Wallabies coach Michael Cheika on when he played against the All Blacks in 1988
Wallabies coach Michael Cheika has a fascinating back story, one that includes making millions in the...
Monday Aug 3, 2015
Ma'a Nonu tells jokes on the couch while confessing his love for chocolate
Ma'a Nonu has a fearsome reputation on the rugby field, known his physicality and eye for...
Sensational Stepper Nehe Milner-Skudder's Tribute Video
Nehe Milner-Skudder has had such an impressive debut season for the Hurricanes that he has been...
Matt Giteau chats to Rugby HQ about his return to the Wallabies
A few months back we wrote about how Matt Giteau could yet prove to be a...


April 4, 2017 - (Motor Sports Newswire) - Husqvarna Motorcycles proudly announce the introduction of their next generation fuel-injected 2-stroke enduro motorcycles. Perfectly embodying the brand's pioneering spirit, the new from the ground up 2018 TE 250i and TE 300i machines will feature engine technology that is set to revolutionise the field of 2-stroke enduro motorcycles.
Enjoying over a century of uninterrupted design, development and production, Husqvarna Motorcycles are now set to add another benchmark to their impressive timeline of innovations. Being one of the oldest motorcycle manufacturers, and the first company to ever produce a purpose-built offroad bike, Husqvarna Motorcycles have always been a great advocate of 2-stroke technology.
From Rolf Tibblin's first Motocross European Championship in 1959 to the golden age of motocross during the 60s and the 70s, Husqvarna has remained a dominant force in the segment of high-performance 2-stroke offroad motorcycles. With their new generation of fuel-injected 2-strokes arriving soon, Husqvarna Motorcycles will proudly start a new chapter in their history of pioneering innovation and forward-thinking development.
This revolutionary new technology will go into production in June. Additional information about Husqvarna's MY18 2-stroke enduro models will be released on May 30, 2017.
Sweet thanks for posting this up!
isn't this post incitement? Seeing how the KTM is a far superior bike and it too has a FI release date? obviously KTM is going to be better since they announced it first. I think I'm going to still sell my old husky and stick my new yamaha for some time. I'm waiting for a flux capacitor before i buy again.
Interesting times for 2strokes. Can't wait to see how these bikes work out. I'll probably buy a new bike for 2020 model year.
Wonder if Husky will import the 300 into the US. KTM is only bringing in the 250 for now.


text:
OWN YOUR LIFE SUPPLEMENT
CITIZEN.CO.ZA
Snowball effect of transmission
If you decide against having the Covid vaccination, could you live with yourself if you contracted the disease and passed it along to others? That's something which has been bugging attorney and Big Tree Copper executive Rupert Smith, pictured.
Just before he was scheduled to be vaccinated, he contracted the virus.
"It's quite ironic that the week before I was scheduled to be vaccinated, I tested positive for the virus," said Smith.
"And while I didn't get as ill as some people have, luckily, I felt sick for several days and was continuously concerned about the wellbeing of my family."
Thankfully, swift isolation and prevention measures at home saved his next of kin from contracting Covid, but Smith's colleagues were not that lucky.
Prior to testing positive, he'd had a meeting with five other people in a boardroom, passing on Covid without knowing.
"We were careful, we didn't shake hands, we never took off our masks, yet three out of the five people in the meeting ended up positive," says Smith. "The downstream impact was that their families also became ill."
From a single meeting, he estimates he directly and indirectly passed on Covid to about eight people.
"We were careful, we didn't shake hands, we never took off our masks, yet three out of the five people in the meeting ended up positive."
Rupert Smith attorney and Big Tree Copper executive
"A colleague and a close friend gave it to his wife and daughter, another to his wife. Fortunately, they all survived, but I felt absolutely terrible and kept worrying about their wellness."
Smith said it was stressful.
"Had I been vaccinated at the time, I may have never contracted the disease, or, I may have not passed it on."
Had everyone in the meeting be vaccinated already, the infection outcome may have been very different, too.
"Getting vaccinated will help us stop this disease in its tracks," says Smith. "It is essential to do so, not only for your own wellbeing but also that of everyone else around you."
His experience is testament to the highly infectious nature of Covid and that despite best efforts, it can still be passed around.
Smith says vaccination is a policy at Big Tree Copper and employees are fully in support of it.
"This is for the greater good, it will prevent people from getting the disease or if they get sick, to endure a milder incarnation."
He says most importantly, it will put a doorstop to people dying, to losing ones we love and care about.
What is a Covid vaccination?
Myths about the Covid vaccines dispelled
Hesitancy: threatens global health
Die-hards see the light
"We miss you, so get jabbed", sports stars tell fans
Passport to life…Just live it
Will I die of the vaccine?
Even Covid survivors at risk of reinfection
© 2022 Citizen Special Features All rights reserved


text:
from __future__ import unicode_literals

from django.db import models, migrations
import django.utils.timezone
import django.contrib.postgres.fields
import django_extensions.db.fields

class Migration(migrations.Migration):

    dependencies = [
    ]

    operations = [
        migrations.CreateModel(
            name='Article',
            fields=[
                ('id', models.AutoField(verbose_name='ID', serialize=False, auto_created=True, primary_key=True)),
                ('created', django_extensions.db.fields.CreationDateTimeField(default=django.utils.timezone.now, verbose_name='created', editable=False, blank=True)),
                ('modified', django_extensions.db.fields.ModificationDateTimeField(default=django.utils.timezone.now, verbose_name='modified', editable=False, blank=True)),
                ('title', models.CharField(max_length=500)),
                ('shop', models.CharField(max_length=500)),
                ('shop_url', models.URLField()),
                ('shop_id', models.CharField(max_length=200, null=True, blank=True)),
                ('description', models.TextField(null=True, blank=True)),
                ('price', models.CharField(max_length=200, null=True, blank=True)),
                ('availability', models.CharField(max_length=200, null=True, blank=True)),
                ('tags', django.contrib.postgres.fields.ArrayField(size=None, null=True, base_field=models.CharField(max_length=200), blank=True)),
                ('image', models.CharField(max_length=500, null=True, blank=True)),
            ],
            options={
                'ordering': ('-modified', '-created'),
                'abstract': False,
                'get_latest_by': 'modified',
            },
        ),
    ]

redpajama_set_name: RedPajamaGithub


Come out to Cape Splash Family Aquatic Center in Cape Girardeau for this year's Mermaid and Pirate Party on Saturday, June 18, from 9 to 10:30 a.m.
Children, ages 8 and under, can get their picture taken with Ariel the Mermaid and Blackbeard the Pirate. Crafts, games, the limbo, refreshments and more will be available.
Adult supervision will be required at all times during the event. Admission is $5 per child. For more information call 573-339-6342 or 573-339-6343.


text:
Віта́лій Мано́лійович Чунтул ( — ) — старший солдат Збройних сил України, учасник російсько-української війни.

Життєпис
Народився 1972 року в місті Чернівці, закінчив чернівецьку ЗОШ № 16. Працював у складі технічного персоналу в чернівецькій обласній лікарні швидкої допомоги (на ліфті). Часто хворів, сім'ї — крім батьків — не мав.

Влітку перебував в лікарні, після одужання мобілізований 14 серпня 2015 року; старший солдат, оператор-радіотелефоніст розвідувально-спостережного відділення, розвідувальний взвод спостереження 54-го окремого розвідувального батальйону. Брав участь в боях на сході України.

Приїздив у відпустку; через місяць мав демобілізуватися.

23 липня 2016 року вранці загинув під час артилерійського обстрілу терористами поблизу села Гнутове. Тоді ж полягли старші солдати Костянтин Бессараб та Володимир Полохало, солдат В'ячеслав Ковальов.

27 липня 2016-го похований у Чернівцях, Руське кладовище.

Без єдиного сина лишилися батьки.

Нагороди та вшанування
 указом Президента України № 345/2016 від 22 серпня 2016 року «за особисту мужність і високий професіоналізм, виявлені у захисті державного суверенітету та територіальної цілісності України, вірність військовій присязі» — нагороджений орденом «За мужність» III ступеня (посмертно).
 нагороджений медаллю «На славу Чернівців» (рішення Чернівецької міської ради, посмертно)
 нагороджений почесним знаком «Маріуполь. Відстояли — Перемогли» (посмертно)
 на вулицях Чернівців були встановлені білборди з фотографіями та словами спомину про героїв антитерористичної операції, зокрема, про Віталія Чунтула
 20 лютого 2017 року в чернівецькій ЗОШ № 16 відкрито меморіальну дошку Віталію Чунтулу.

Примітки

Джерела
 Книга пам'яті
 Український Меморіал

Уродженці Чернівців
Померли в Маріуполі
Поховані в Чернівцях

redpajama_set_name: RedPajamaWikipedia


text:
package com.yahoo.ml.caffe

import java.io.File
import com.yahoo.ml.caffe.tools.Binary2Sequence
import org.apache.hadoop.conf.Configuration
import org.apache.hadoop.fs.Path
import org.apache.spark.{SparkConf, SparkContext}
import org.scalatest.{BeforeAndAfterAll, FunSuite}
import org.slf4j.LoggerFactory
import org.testng.Assert._

import caffe.Caffe._
import com.yahoo.ml.jcaffe._

class SourceTest extends FunSuite with BeforeAndAfterAll {
  val log = LoggerFactory.getLogger(this.getClass)
  var sc : SparkContext = null
  var conf : Config = null

  override def beforeAll() = {
    sc = new SparkContext(new SparkConf().setAppName("caffe-on-spark").setMaster("local"))

    val ROOT_PATH = {
      val fullPath = getClass.getClassLoader.getResource("log4j.properties").getPath
      fullPath.substring(0, fullPath.indexOf("caffe-grid/"))
    }
    val solver_config_path = ROOT_PATH + "caffe-grid/src/test/resources/caffenet_solver.prototxt";
    val args = Array("-conf", solver_config_path,
      "-model", "file:"+ROOT_PATH+"caffe-grid/target/model.h5",
      "-imageRoot", "file:"+ROOT_PATH+"data/images",
      "-labelFile", "file:"+ROOT_PATH+"data/images/labels.txt"
    )
    conf = new Config(sc, args)

    val seq_file_path = "file:"+ROOT_PATH+"caffe-grid/target/seq_image_files"
    val path = new Path(seq_file_path)
    val fs = path.getFileSystem(new Configuration)
    if (fs.exists(path)) fs.delete(path, true)

    val b2s = new Binary2Sequence(sc, conf)
    assertNotNull(b2s)
    b2s.makeRDD().saveAsSequenceFile(seq_file_path)
  }

  override def afterAll() = {
    sc.stop()
  }

  test("Config test") {
    assert(conf.clusterSize >= 1)
    assertEquals(conf.train_data_layer_id, 0)
    assertEquals(conf.test_data_layer_id, 1)
  }

  test("Training source") {
    val source =  new SeqImageDataSource(conf, conf.train_data_layer_id, true)

    //caffenet
    val net = new CaffeNet(conf.protoFile, "", "", 1, 1, 0, true, 0, -1)
    assertTrue(net != null)
    assertTrue(net.connect(null))

    //initialization
    assertTrue(source.init())
    assertTrue(source.batchSize() > 0)
    assertTrue(source.isTrain)

    //RDD
    val rdd = source.makeRDD(sc).persist()
    assertNotNull(rdd)

    //dummy objects
    val label = new FloatBlob()
    assertNotNull(label)
    val batchSize = source.batchSize()
    label.reshape(batchSize, 1, 1, 1)
    val data = source.dummyDataBlobs()
    assertNotNull(data)
    val matVector = source.dummyDataHolder()
    assertNotNull(matVector)
    val sampleIds = new Array[String](batchSize)

    //source transformer
    val transformer = new FloatDataTransformer(source.transformationParameter, true)
    assertNotNull(transformer)

    //simplified training
    log.info("SourceTest train:")
    for (i <- 0 until 5) {
        //feed training data to source queue
        var res = rdd.take(source.batchSize()).map(source.sourceQueue.offer(_)).reduce(_ && _)
        assertTrue(res)

        //next batch
        res = source.nextBatch(sampleIds, matVector, label)
        assertTrue(res)

        //tranform the data blob
        transformer.transform(matVector, data(0))

        //training
        assertTrue(net.train(0, data, label.cpu_data))
    }

    //save snapshot
    val filePath = conf.modelPath.substring("file:".length);
    val f = new File(filePath)
    if (f.exists()) f.delete()
    FSUtils.GenModelOrState(net, conf.modelPath, false)
    assertTrue(new File(filePath).exists())

    net.deallocate();
  }

  test("Test source") {
    val source =  new SeqImageDataSource(conf, conf.test_data_layer_id, false)

    //caffenet
    val test_net = new CaffeNet(conf.protoFile, "", "", 1, 1, 0, false, 0, -1)
    assertTrue(test_net != null)
    assertTrue(test_net.connect(null))

    //initialization
    assertTrue(source.init())
    assertTrue(source.batchSize() > 0)
    assertTrue(!source.isTrain)

    //RDD
    val rdd = source.makeRDD(sc)
    assertNotNull(rdd)

    //dummy objects
    val label = new FloatBlob()
    assertNotNull(label)
    val batchSize = source.batchSize()
    label.reshape(batchSize, 1, 1, 1)
    val data = source.dummyDataBlobs()
    assertNotNull(data)
    val matVector = source.dummyDataHolder()
    assertNotNull(matVector)
    val sampleIds = new Array[String](batchSize)

    //source transformer
    val transformer = new FloatDataTransformer(source.transformationParameter, false)
    assertNotNull(transformer)

    //feed training data to source queue
    var res = rdd.take(source.batchSize()).map(source.sourceQueue.offer(_)).reduce(_ && _)
    assertTrue(res)

    //next batch
    res = source.nextBatch(sampleIds, matVector, label)
    assertTrue(res)

    //tranform the data blob
    transformer.transform(matVector, data(0))

    //test
    val test_features : Array[String] = Array("accuracy","loss")
    val top_blobs_vec = test_net.predict(0, data, label.cpu_data, test_features)

    //validate test results
    for (j <- 0 until top_blobs_vec.length) {
      val result_vec = top_blobs_vec(j).cpu_data
      assertTrue(result_vec.get(0) < 50.0)
    }

    test_net.deallocate()
  }
}


text:
Holiday, inclement weather & closing information
Teach a course
High School Equivalency Prep & ESOL
STEM Alliance Partnership
Community Advisory Network
Afterschool Enrichment Program Policies
The Female Gaze: Journeys of Self-Discovery Directed By Women
Film historian Kate Hearst curates this film series, highlighting five features directed by women that explore journeys of self-discovery. After a short introduction where Kate will suggest elements to look for in each film, we'll screen the movies together and have a discussion afterward. Kate will focus on each film's unique place in history and it's cinematic techniques, such as narrative structure, cinematography and visual construction. Together we'll find meanings both visible and hidden, and discuss why each film continues to be a milestone in cinema today.
The films include: Cléo from 5 to 7 (Agnés Varda, 1962), Daughters of the Dust (Julie Dash, 1991), The Piano (Jane Campion, 1993), Frida (Julie Taymor, 2002), and Toni Erdmann (Maren Ade, 2016).
Kate Hearst is a film historian and critic, recently seen in CNN's "The History of the Movies." Since 2011, Kate has been teaching film studies at various New Feirstein Graduate School of Cinema, and Brooklyn College. She regularly writes for Film International and advises the web-based series, Women Film Pioneers Project (WFPP). She earned her Ph.D. in American History and MFA in film, both from Columbia University.
5 Thursdays
Jan 16th – Feb 13th
Mamaroneck High School
Our History & Philosophy
Based in Mamaroneck for over 40 years, we offer quality classes about anything and everything to residents throughout the area. We're a self-sustaining non-profit, receiving no support from school districts or grants.
Whether you come for intellectual engagement or social connection – or both – you'll become a part of our growing family of lifelong learners.
The Center for
1000 W Boston Post Rd
Email: lmcceregistrar@mamkschools.org
Mon - Thurs 9:00 am - 1:00 pm
Closed during Mamaroneck School District holidays
Copyright © 2020 The Center for Continuing Education. All Rights Reserved


text:
Game of Thrones Pilots Guide Premieres Renewal Scorecard TV's Top 5 Series Regular Grey's TWD
January 14, 2019 12:00pm PT by Lesley Goldberg
Matthew Rhys to Play Perry Mason in HBO Drama
Jon Kopaloff/FilmMagic
The 'Americans' grad takes over the role from Robert Downey Jr., who continues to exec produce the long-in-the-works limited series.
HBO's long-in-the-works Perry Mason drama is officially moving forward.
The Americans grad Matthew Rhys has been tapped to star in the limited series, taking over the title role from Robert Downey Jr. The latter will remain on board as an executive producer on the series, which is searching for a director.
Downey had been attached to star in the long-gestating Perry Mason reboot that was originally envisioned as a feature film. The HBO entry was first put into development in August 2016 with Nic Pizzolatto attached to pen the script. Rolin Jones and Ron Fitzgerald replaced Pizzolatto as writers on the project in August 2017 after the latter shifted gears to focus on season three of True Detective.
Based on the characters created by Erle Stanley Gardner, HBO's Perry Mason will follow the character at a time in his life when he is living check-to-check as a low-rent private investigator. Mason is haunted by his wartime experiences in France and is suffering the effects of a broken marriage.
Rhys will also produce the series. Downey exec produces alongside his Team Downey partners Susan Downey and Amanda Burrell as well as Jones, Fitzgerald and Joe Horacek. Jones and Fitzgerald (Boardwalk Empire, Friday Night Lights) will serve as showrunners.
Here's the official logline, from HBO: "1932, Los Angeles. While the rest of the country recovers from the Great Depression, this city is booming! Oil! Olympic Games! Talking Pictures! Evangelical Fervor! And a child kidnapping gone very, very wrong! Based on characters created by Erle Stanley Gardner, this limited series follows the origins of American Fiction's most legendary criminal defense lawyer, Perry Mason. When the case of the decade breaks down his door, Mason's relentless pursuit of the truth reveals a fractured city and just maybe, a pathway to redemption for himself."
The character of Perry Mason, a Los Angeles defense attorney, served as the inspiration for the CBS series of the same name. The drama ran from 1957 to 1966 and starred Raymond Burr in the title role.
Perry Mason is the latest TV foray for Team Downey, which has a first-look pact with Sonar Entertainment. The company's credits include the TNT pilot Constance, starring Elisabeth Shue; Hulu's Sweet Tooth; and the YouTube docuseries Age of AI.
For his part, Rhys is fresh off his award-winning role on FX's The Americans. On the feature side, he recently wrapped production on A Beautiful Day in the Neighborhood and counts The Post among his credits. Rhys is with WME, Management 360, United Agents and Sloane Offer.
Perry Mason arrives as HBO is under a mandate from new corporate leadership to increase its roster of scripted originals. New series coming to the premium cable network this year include Watchmen, Euphoria, Catherine the Great and The Righteous Gemstones, as well as the returning hits Game of Thrones, Veep, Succession, Ballers, Barry, Big Little Lies, Divorce and more.
Lesley Goldberg
Lesley.Goldberg@THR.com Snoodit
TV Scorecards
TV Premiere Dates 2019: The Complete Guide
TV Pilots 2019: The Complete Guide
Broadcast TV Scorecard 2019: Complete Guide to What's New, Renewed and Canceled


Croatia Travel Insurance Quotes | Zoom to it!
With emerald forests, sapphire waters and now King's Landing, Croatia's awe-inspiring landscapes are an adventurer's dream. Scroll on down for our handy guide to one of the world's most popular travel destinations. Zoom's Croatia travel insurance has you covered for any unexpected holiday hurdles. Cover includes medical expenses should you fall sick or become injured, as well as cover for trip cancellation, lost luggage, family emergencies and more! What are you waiting for? Zoom to it!
Setbacks on your sojourn are never much fun. Cover your Croatian travel disruptions in a flash with Zoom travel cover. We keep things zippy!
Driving to Dubrovnik? Our rental vehicle excess add-on is a must for roadtripping travellers.
Whether it's uninhabited islands or glamorous hotels, this place has something for everyone. A cultural melting pot of southern and central European quirks, with Catholic, Islamic and Orthodox Christian influences, Croatia is a must-see destination for adventurous travellers.
Go on, zoom to Croatia and find out for yourself!
No matter which kind of Croatian experience you're planning, Zoom can cover your trip with a range of plans. You can minimise your costs with Medical Only cover, or choose to buy Comprehensive Travel Insurance for extra protection to cover things like travel delays and cancellation. Compare Zoom's Travel Insurance plans online today.
Aussies and Kiwis visiting Croatia score up to 90 days visa-free before you need one or have to leave. If you leave Croatia for 180 days, you can come back for another 90 visa-free days. Too easy! Also, while it's a member of the Eurozone, Croatia isn't a part of the Schengen Area - so any days you spend in Croatia don't count towards your 90-day Schengen Area allowance!
These rules can change quickly. Contact your nearest Croatian Embassy or Consulate before you travel for the most up to date information.
Croatia is accessible by road and rail from other parts of Europe, with popular connections through Solvenia, Austria, Serbia and Hungary, or intercontinentally via plane through a number of intermediary countries. International flights often arrive in the capital, Zagred, or Dubrovnik.
Make sure you have all your documents handy for border crossings, as moving around isn't quite as a flexible as the Schengen Area countries.
While catching the train is one of the best ways to get around much of Europe, it's a little trickier in Croatia. While the national railway connects many cities, some southern spots aren't serviced. Don't worry - there are a number of companies which form an extensive bus network which get you just about anywhere.
If crystal-clear waters are calling your name, then visit some of Croatia's 1200 islands via ferry. Island hopping can be a little inflexible with the commerical ferry operators though, so if you're looking for a highly bespoke experience, why not charter a boat?
Spring is well into first gear by late-March (the water is even warm enough to swim in around Dalmatia!) and great time to start your trip to Croatia. Try to be out of there by July/August - peak season in Adriatic - if you're averse to crowds. Otherwise, think about visiting in Autumn, when the mix of deciduous and evergreen green trees making trekking a magical experience.
Visit Dubrovnik for its historic walled-in city, stunning Renaissance and Baroque architecture and sapphire-blue water. With its almost mythical look, it has been the site of many popular TV shows and films, including Game of Thrones and Star Wars: The Last Jedi. Take the cable car to get a bird's eye view, or get up close and walk the fortified city walls - just don't forget to bring a drink bottle!
While traditionally travellers have ignored it in favour of its coastal sisters, Croatia's capital, Zagreb, is a quirky, gritty metropolis. Hike up Bear Mountain, explore the Baroque palaces of Gradec, or enjoy the hustle of Trg bana Jelacica's cafes and restaurants. If you're visiting Zagreb from late May to early September, be sure to check out the Strossmartre Festival, a season-long series of outdoor concerts. Can't stay that long? Check out the InMusic Festival in late June - this three-day, camping-friendly music festival attracts headliners from all over world.
For a complex cultural scene, you can't go past Istria. With a strong Italian community, the cusine, art and architecture here is a unique mix of Mediterranean - thanks to Roman ruins and cobblestone squares - and Middle European, with Medieval churches and townships.
You have to register your place of residence with the local police station within 24 hours of arriving. If you're staying in commercial accomodation, they're usually do it for you, but it's a good idea to check.
You may have heard that unexploded landmines are a problem in Croatia, and that remains true, these are easily avoided if you stick to tourist cities, and don't stray from the path when hiking.
Are you planning to zoom somewhere else on your European holiday? Whether it's another Balkan country like Greece, the architectural awe of neighboring countries Hungary or Italy, or whether London is calling, we've got plenty of helpful advice on other popular travel destinations to check out. What are you waiting for? Zoom to it!
Got some curly questions in regards to your Croatia travel insurance cover?
Am I covered medically while holidaying in Croatia?
What happens if I need medical assistance in Croatia?
Have complete peace of mind on your Croatian adventure. Zoom provides immediate support through our emergency assistance provider, First Assistance. Help is just a phone call away any time of day 365 days a year. This includes access to medical advisors, medical transfers and emergency evacuation if required. We also assist with passing on messages to family and returning unsupervised dependants back to Australia.
When it comes to alcohol we advise you to drink in moderation. One too many Osjeckos could see you jeopardizing your cover. Please note that we may exclude any claims where excessive drugs or alcohol have been involved.
Am I covered for pickpocketing in Croatia?
Yes, you're covered for muggings, provided of course you were acting with reasonable care (i.e. did not leave your belongings unattended). If you're the victim of a pickpocket, you'd be covered for loss, theft and damage to your luggage and personal effects. If you are robbed it's important that you get a police report and contact us as soon as possible.


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Kia Forte 3rd Generation 2019+
Updated pictures of my 2021 Forte (K3) GT + GT2
ZiggyM5
2021 Forte GT- Currant Red - GT2 Package - Ambien Lights
Here are some recent pics of my GT. I hope you like it.
The story of my GT.
1. My illusion of getting a GT started when I got my first Kiam, a 2018 Rio Sedan/and. A new Forte GT was very intriguing to me as a sport/sporty cars aficionado.
2. After grueling research, I found out the no one in Puerto Rico has it nor plans to bring it to the Island (as a new car, not even the local distributor, MotorAmbar).
3. Soon after I realized that there was no way to get it locally, I decided to test my luck and do business with a USA dealer. I selected Orlando because my sister lives near the dealer.
4. Started negotiation in mid-September 2020. Soon, a plethora of problems started to spark everywhere.
a. First: No bank will finance a car going to Puerto Rico. OK! Let try the other way around.
b. No bank in Puerto Rico will finance a car coming from offshore unless a registered dealership brings it to the Island.
c. After some serious analysis, research, calculations, and more, I decided I had to pay the car in full and ship it down to PR.
d. First solution proposed: Register the car to my name, but with my sister's address. Strike one! No-can-do.
d. Second solution proposed: Register the car to my sister's name and address. That seems the way to go. Weeks, after weeks, and no news, my sister went to the dealership and requested an explanation of why is taking so long to finish the deal. The answer: Florida MVD was to fault.
e. After some more debates, the dealer's Sales Manager finally confessed it was Kia who didn't want to approve the deal if the car was going to PR. The solution is to register the car as I will stay in Florida and "buy" the car from my sister for $0.00. The deal was approved, and I paid the balance, and the process started.
5. Finally, my sister finally bought the car. My sister wanted to leave the car at the dealership, but I told her the car was fully paid for and was not their responsibility, and I preferred that she store the car at her house. With a temporary registration and paper plate, she drove the vehicle safely to her house.
6. Negotiations with the carrier lasted about three more weeks to pick up the car and transport it to Jacksonville port.
7. At this point, the broker doesn't respond to my calls. Asking what the status is—the car was sitting in the dock for more than a week. I bought access to an app that will tell me the ship's location. The broker said to me that it would be a matter of a couple of days. He never called me, and I found out that they had to deliver some paperwork. I called and let him know. Then he started the process, but just because I told him. Otherwise, the car will be sitting there for I don't know how long. Finally, the car got onto the ship.
8. I started tracking the ship every day. According to the information, they told me that it would take three (3) days once it ships out. Nice, I say.
9. I tracked the ship until it arrived at San Juan port. There was some more paperwork for excise tax, MVD registration, pay the 2nd. Half to the shipping cost to the local maritime office. Someone recommended a broker who could do that for me since I didn't know much of the procedure. I talked to him the same day the ship arrived in Puerto Rico. He told me he would call me back. Then, two days, three days, four days, and my car was sitting again in a parking lot that I should pick up, and after five days, they will start charging storage fees. That is when I decided to go and start asking all around the location in the San Juan port.
10. I have problems on both my knees, so walking all around was a "little" uncomfortable for me. Finally, after several visitations to several offices and making payments to everyone involved in the transaction, finally, my car is freed for me to take it. However, I was informed to pick up the car; I had to prove the car was sold to me by my sister at $0. To my surprise, they got the car, gave me the keys and paperwork with the engine, and the A/C running to bear to get into a car with black interiors under the blazing sun, which is usual in Puerto Rico.
I finally drove my car, with no plates, marks, and writhing in almost every window. So, yes, I got my car, but then it took me another week to make the final paperwork to get the license, title, and plates. Finally, I can use my new 2021 Forte GT +GT2
The pre-beginning. My car parked someplace on the shore of St. Johns River in Jacksonville.
The car is home, and now plain water washes to clear all the dust that covers it.
The engine bay mus be clean and shiny.
Looking clean!
The changes and updates started:
RaceChip + Android App
Increased performance:
Paddle shifts, New Kia emblem:
... continue ...
Reactions: mobileterminaluser and ForteGT2
ForteGT2
2021 Forte GT w/GT2, Currant Red, Wagner-Tuning Intercooler, Evilla Exhaust, Takeda S1 Intake
New Dictionary definition for DETERMINED:
Determined definition is - having a strong feeling that you are going to do something and that you will not allow anyone or anything to stop you, See ZiggyM5!!!
2021 Forte GT, GT2 Package, Currant Red, DCT
Reactions: HaCkStArAcE, mobileterminaluser and ZiggyM5
ZiggyM5 said:
3. Soon after realizing that there was no way to get it locally, I decided to test my luck and do business with a USA dealer. I selected Orlando because my sister lives near the dealer.
View attachment 84849 View attachment 84850
The engine bay must be clean and shiny.
New Kia emblem:
Under construction. I am thinking about new enhancements. Not decided yet what's the next step. Intake/exhaust interested me a lot, but I don't know If I will go that way. Bigger brakes are another area of interest.
Let see how I ended up with.
Reactions: ForteGT2
ForteGT2 said:
Yes indeed! Lol 😁
"Let see how I ended up with."
Decisions, decisions:
aFe Takeda Intake
Velossa Tech Big Mouth intake
Intercooler, Wagner or SXTH
Exhaust. Evilla or X-Force
Reactions: mobileterminaluser and ZiggyM5
ForteGT2 Nov 11, 2021


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Published On: Sat, Apr 22nd, 2017
Huawei Launches Two MediaPad T3 Tablets
After a lot of rumors, the Chinese smartphone manufacturer has finally announced two mid range tablets, called the 7 inch MediaPad T3 and the larger 8 inch MediaPad T3. It is expected that company will launch 10 inch and the lite version of this tablet as well, very soon. Before the announcement of MediaPad tablet, the company has already launched two new smartphones, called Huawei P10 and P10 plus. Both come with high end features and impressive specs, and the notable thing is dual camera setup. At VogaTech, there is everything you need to know about Huawei newly arrived smartphones.
The affordable tablet features a 7 inch IPS display with the screen resolution of 1, 2040 pixels by 600 pixels. The tablet runs on the outdated operating system, Android 6.0 Marshmallow OS and it is customized with EMUI 4.1 skin. It is powered by the MediaTek MTK8127 quad core processor, which clocked at 1.3 GHz.
Regarding the storage, the tablet come with two variants, either a 1GB RAM with 8GB of internal storage or 2GB of RAM along with 16GB of built-in storage. As far as the camera concerned, the tablet spots 2 megapixel sensors on both front and rear as well. The tablet boasts with a 3,100mAh battery. The device will available in two color choices, namely Space gray and Moonlight silver. The device will support only Wi-Fi, there is LTE support.
This variant of the MediaPad tablet features an 8 inch IPS display which carries the support for 1,280 × 800 pixels resolutions. Fortunately, this model runs on the latest version of operating system, an Android 7.0 Nougat OS modified with EMUI 5.1. To fuel the tablet, there is a Qualcomm Snapdragon 425 quad core processor clocking at 1.4 GHz. The tablet is equipped with either a 2GB of RAM plus 16GB of storage or 3GB of RAM along with 32GB of internal storage.
Regarding the photography, the tablet comes with 5 megapixel rear camera with autofocus, while on the front, there is a fixed focus 2 megapixel front facing camera for taking selfies. It includes a larger battery than the 7 inch model, it packs 4,800mAh battery. As far as the connectivity is concerned, the tablet comes with the support for Wi-Fi and LTE as well. It will available in two color options: Space gray and luxurious gold.


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Clearly I have an unhealthy obsession with the cast of Full House and Full House references so I only see it fitting that I fill you all in on the news that Jodie Sweetin, Stephanie Tanner, recently got married in Vegas. Jodie, who is only 25, has been married once before but her marriage crumbled when Jodie got addicted to Crystal Meth. See what happens when you start out by going to Gia's make-out party? First you're attending a make-out party and then you're hooked on meth. It's a natural progression. Anyway, no word if the Olsen Skanks attended the Vegas wedding, but one thing is for sure…Papooli definitely didn't attend the wedding because he died while visiting the Tanners. We'll miss you Papooli, but you'll always be there in spirit…and in reruns.
Jodie Sweetin Has Baby. How Rude!


Has your once stellar credit report gone down the drain, and now that you need a new car, you fear that you won't qualify for an automobile loan? Best Chance Auto Loan specializes in procuring reasonable loans for individuals with negative credit ratings. In fact, we have Bad Credit Car Loans in Tacoma and an outstanding collection of affordable vehicles on our car lot.
Nobody wants a negative credit rating. Unfortunately, in today's economy, it is relatively easy to accrue a bad credit report. In fact, just one trip to the emergency room can wipe out a life savings account, and if you compound that with an extended stay in the hospital, a divorce, or death in the family, it won't be long until your credit is in the toilet. Best Chance Auto Loan understands that bad credit can happen to anybody, and we want to give people a second chance. That's why we have Bad Credit Car Loans in Tacoma.
In fact, we specialize in bad credit car loans. Our financial specialists work with numerous reputable loan agencies, and work hard to get their customers a financial plan that works for them. Best of all, the loan application is free, fast, and productive. It only takes a few minutes to complete the form, and a few more minutes to get your loan approved. Once you start making monthly payments on your car, your credit rating will improve, and before long, you will once again have an acceptable credit rating.
Best Chance Auto Loan does more than just supply Bad Credit Car Loans in Tacoma. In fact, we have an outstanding collection of affordable pre-owned vehicles in our inventory. Whether you need a fuel-efficient hatchback to commute to work, a van or full sized sports utility vehicle to deliver the kids to their extracurricular activities, a truck to knock items off the to do list, or a sedan, we have the vehicle you have been longing for.
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Vaginal E: Estriol (E-3) Img/dose in a non-systemic Cream.
Bio-identical hormones have the same chemical structure as hormones that are made by the human body. The term "bio-identical" does not indicate the source of the hormone, but rather refers to the chemical structure. In order for a replacement hormone to fully replicate the function of hormones which were originally naturally produced and present in the human body, the chemical structure must exactly match the original. Bio-identical hormones are able to follow normal metabolic pathways so that essential active metabolites are formed in response to hormone replacement therapy.
There are significant differences between hormones that are natural to humans (bio-identical) and non-bio-identical (including horse) preparations. Side chains can be added to a naturally-occurring hormone to create a synthetic drug that can be patented by a manufacturer. A patented drug can be profitable to mass produce, and therefore a drug company can afford to fund research as to the medication's use and effectiveness. However, bio-identical substances can not be patented, so scientific studies are less numerous on natural hormones, because medical research is usually funded by drug companies. Structural differences that exist between bio-identical human, and non-bio-identical synthetic and animal hormones may be responsible for side effects that are experienced when non-bio-identical hormones are used for replacement therapy.
Bio-identical hormones include estrone (E1), estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHEA), and pregnenolone. Our compounding specialists work together with patients and prescribers to provide customized bio-identical hormone replacement therapy that provides the needed hormones in the most appropriate strength and dosage form to meet each woman's specific needs. Hormone replacement therapy should be initiated carefully after a woman's medical and family history has been reviewed. Every woman is unique and will respond to therapy in her own way. Close monitoring and medication adjustments are essential.
The findings of numerous studies on hormone replacement therapy (HRT) conflict and, as a result, have raised serious questions regarding the appropriateness of HRT. Hormone replacement is an approved therapy for relief from moderate to severe hot flashes and symptoms of vulvar and vaginal atrophy. Numerous studies have confirmed that estrogen replacement decreases the risk of colon cancer, estrogen and progesterone decrease fracture risk, and various hormones increase energy levels and enhance libido. Reputable sources offer conflicting reports regarding issues such as memory, Alzheimer's disease, and stroke.
With the exception of the Postmenopausal Estrogen/Progestin Intervention (PEPI) study, major studies have either failed to distinguish among types and dosages of HRT used in the study, or examined only the use of synthetic HRT preparations (as in the case of the Women's Health Initiative). The Women's Health Initiative (WHI) study was designed to identify the potential risks and benefits of HRT. The estrogen-progestin portion of the clinical trial was stopped in 2002 after results showed that a synthetic hormone combination containing conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) increased the women's risks of developing invasive breast cancer, heart disease, stroke, and pulmonary embolism. The data and safety monitoring board concluded that the risks outweighed the evidence of benefit for fractures and colon cancer. Utilizing data from the WHI, researchers later concluded that synthetic CEE plus MPA does not improve mental functioning and may increase the risk of dementia in women over age 65. They suggest these hormones increase the risk of stroke, which is known to increase the risk of dementia. With regard to the risk of dementia, typical HRT users are in their 50s and the WHI study focused on women aged 65 and over, who have a higher risk for dementia. The "estrogen-only" portion of the WHI study was halted in March 2004 after analysis of data suggested that synthetic CEE alone had no impact either way on heart disease (the main focus of the study), but may increase the risk of stroke.
Many patients and medical professionals are unaware of the availability of bio-identical alternatives. In reality, women's experiences and clinical outcomes of HRT differ vastly depending on the dose, dosage form, and route of administration, and most importantly, whether the hormones are synthetic or bio-identical. As a result of concerns and doubts generated by studies that use synthetic hormones, many women who could substantially benefit from bio-identical hormone replacement may never have the opportunity.
Published research delineating the differences between natural bio-identical and synthetic HRT is now more abundant, but studies of bio-identical HRT will probably never be as plentiful as those dealing with patented synthetic hormones. Our pharmacy welcomes your questions.
Estrone -E1- (10-20% of circulating estrogens) is the primary estrogen produced after menopause.
Estradiol -E2- (10-30% of circulating estrogens) is the most potent and major secretory product of the ovary, and the predominant estrogen produced before menopause.
Progesterone is a term that is incorrectly used interchangeably to describe both natural bio-identical progesterone and synthetic non- bio-identical derivatives. Synthetic progestins (also called progestogens or progestational agents) are analogues of bio-identical progesterone, and have been developed because they are patentable, more potent, and have a longer duration. Medroxyprogesterone acetate, the most commonly used synthetic progestin, was shown in a large study to cause significant lowering of HDL "good" cholesterol, thereby decreasing the cardioprotective benefit of estrogen therapy. Bio-identical progesterone has not been reported to produce any serious side effects when administered in physiologic doses. However, progestins can have significant and serious side effects at typical doses, including migraine headache, weight gain, mood swings, depression, irritability, acne, menstrual irregularities, and fluid retention. These side effects are a frequent cause for discontinuation of HRT. Only about 20% of women who start synthetic HRT remain on it two years later.
may enhance the beneficial effect of estrogen on lipid and cholesterol profiles and exercise-induced myocardial ischemia in postmenopausal women (in contrast to medroxyprogesterone acetate).
The benefits of progesterone are not limited to prevention of endometrial cancer in women who are receiving estrogen replacement. Progesterone therapy is not only needed by women who have an "intact uterus", but is also valuable for women who have had a hysterectomy. Vasomotor flushing is the most bothersome complaint of menopause, and is the most common reason women seek HRT and remain compliant. For over 40 years, estrogens have been the mainstay of treatment of hot flashes, but transdermal progesterone cream may be effective as well. Women who have had postpartum depression once have about a 68% chance of having it again after another pregnancy, but trials using prophylactic progesterone have shown that it is possible to reduce the recurrence rate to 7%. Other benefits include improved bone density and enhanced glucose utilization.
Estrogen replacement restores atrophic mucosa, lowers vaginal pH, and may prevent urinary tract infections in postmenopausal women.
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections.
In order to access the PubMed abstract of this article, visit this website link.
Low dose vaginally administered estradiol and estriol are equally efficacious in alleviating lower urinary tract symptoms which appear after menopause.
Intravaginal administration of estriol may represent a satisfactory therapeutic choice for those postmenopausal women with urogenital tract disturbances who have contraindications or refuse to undergo standard hormone therapy.
Efficacy of low-dose intravaginal estriol on urogenital aging in postmenopausal women.
The following finding that conjugated equine estrogen but not esterified estrogen was associated with venous thrombotic risk may have implications for the choice of hormones in perimenopausal and postmenopausal women.
Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis.
Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, Larson EB, Rosendaal FR, Psaty BM.
These observations suggest that the addition of testosterone to conventional hormone therapy for postmenopausal women does not increase and may indeed reduce the hormone therapy-associated breast cancer risk-thereby returning the incidence to the normal rates observed in the general, untreated population.
Dimitrakakis C, Jones RA, Liu A, Bondy CA.
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
The pharmacodynamic differences of testosterone and methyltestosterone are briefly reviewed in the context of choice for individualized clinical use.
Hot flashes and androgens: a biological rationale for clinical practice.
The results of this study suggest a significant reduction in the incidence of type 2 diabetes in our population of non-obese, healthy postmenopausal women who used transdermal 17-beta-estradiol. This could suggest that, in some women, the estrogen deficiency that occurs after menopause could represent a fundamental step in the process of diabetogenesis.
Transdermal 17-beta-estradiol and risk of developing type 2 diabetes in a population of healthy, nonobese postmenopausal women.
Rossi R, Origliani G, Modena MG.
Mayo Clinic researchers surveyed 176 women taking natural bio-identical micronized progesterone who had previously taken synthetic progestins. After one to six months, the women reported an overall 34% increase in satisfaction on micronized progesterone compared to their previous HRT, reporting these improvements: 50% in hot flashes, 42% in depression, and 47% in anxiety. Micronized progesterone was also more effective in controlling breakthrough bleeding.
Comparison of regimens containing oral micronized progesterone or medroxyprogesterone acetate on quality of life in postmenopausal women: a cross-sectional survey.
Fitzpatrick LA, Pace C, Wiita B.
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Micronized progesterone: clinical indications and comparison with current treatments.
Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Rosano GM, Webb CM, Chierchia S, Morgani GL, Gabraele M, Sarrel PM, de Ziegler D, Collins P.
The PEPI Trial, a 3-year multicenter, randomized, double-blind, placebo-controlled study of 875 healthy postmenopausal women, confirmed that synthetic progestins partially negate the beneficial effects on cholesterol levels that result from taking estrogen. Natural bio-identical progesterone, on the other hand, maintains all the benefits of estrogen on cholesterol without any of the side effects associated with synthetic progestins, such as medroxyprogesterone acetate.
Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial.
The Writing Group for the PEPI Trial.
Certain progestogens, such as micronized progesterone, can be administered concurrently with estrogen replacement therapy, providing protection against endometrial hyperplasia without significantly affecting the beneficial effects of estrogen on lipid profiles, atherosclerosis and vascular reactivity.
Rationale for hormone replacement therapy in atherosclerosis prevention.
Estrogen status correlates with the calcium content of coronary atherosclerotic plaques in women.
Christian RC, Harrington S, Edwards WD, Oberg AL, Fitzpatrick LA.
Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Estradiol attenuates programmed cell death after stroke-like injury.
Rau SW, Dubal DB, Bottner M, Gerhold LM, Wise PM.
Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA.
Minireview: Neuroprotective Effects of Estrogen-New Insights into Mechanisms of Action.
Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536.
The use of conjugated equine estrogen plus medroxyprogesterone acetate in a double-blind, randomized, controlled trial of 16,608 postmenopausal women between the ages of 50 and 79 years doubled the risk of venous thrombosis. This horse estrogen plus synthetic progestin therapy increased the risks associated with age, overweight or obesity, and factor V Leiden.
Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, Sidney S, Rosendaal FR; Women's Health Initiative Investigators.
The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.
Department of Medicinal Chemistry and Pharmacognosy (M/C 781), College of Pharmacy, The University of Illinois at Chicago, IL, USA.
The following study concluded that in non-human primates, medroxyprogesterone in contrast to progesterone increases the risk of coronary vasospasm. Progesterone plus estradiol protected but medroxyprogesterone plus estradiol failed to protect, allowing vasospasm.
Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm.
Miyagawa K, Rosch J, Stanczyk F, Hermsmeyer K.
Oregon Regional Primate Research Center, Oregon 97006, USA.
MPA reduces the dilatory effect of estrogens on coronary arteries, increases the progression of coronary artery atherosclerosis, accelerates low-density lipoprotein uptake in plaque, increases the thrombogenic potential of atherosclerotic plaques and promotes insulin resistance and its consequent hyperglycemia. These effects may be largely limited to MPA and not shared with other progestogens.
Progestogens and cardiovascular disease. A critical review.
Significant bone loss occurs during the 10 to 15 years before menopause when estrogen levels are still normal. Progesterone can stimulate new bone formation in women with osteoporosis. Dr. Prior measured estrogen and progesterone levels in female marathon runners who had osteoporosis. Although their estrogen levels were still high, they had stopped ovulating (common in female athletes) and progesterone levels had fallen, triggering the onset of osteoporosis. This can indicate a role for progesterone use, alone or combined with estrogen which reduces bone loss, in improving Bone Mineral Density.
Progesterone as a bone-trophic hormone.
Division of Endocrinology and Metabolism, University of British Columbia, Vancouver, Canada.
The WHI assessed the major health benefits and risks of the most commonly used combined hormone preparation in the United States, the synthetic combination of conjugated equine estrogens and medroxyprogesterone acetate. Absolute excess risks per 10,000 person-years attributable to this synthetic hormone combination were 7 more CHD events, 8 more strokes, 8 more pulmonary emboli, and 8 more invasive breast cancers, while absolute risk reductions per 10,000 person-years were 6 fewer colorectal cancers and 5 fewer hip fractures.
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators.
Division of Women's Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817, USA.
Among postmenopausal women aged 65 years or older, synthetic estrogen plus progestin did not improve cognitive function when compared with placebo. However, typical HRT users are in their 50s and this study focused on women aged 65 and over, who have a higher risk for dementia.
Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Estrogen plus progestin increases the risk of ischemic stroke in generally healthy postmenopausal women. This finding is consistent with the differences noted earlier between synthetic medroxyprogesterone acetate and bio-identical progesterone.
Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, Curb JD, Black H, Rossouw JE, Aragaki A, Safford M, Stein E, Laowattana S, Mysiw WJ; WHI Investigators.
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
and some patients switched to Nature‐Throid™ and Westhroid™ again. Currently, there is a nationwide shortage of Armour Thyroid®, and Forest has not indicated any date when the product will be back on the market. Nature‐Throid™ and Westhroid™, distributed by RLC Labs and until recently, manufactured by TimeCap Labs, are also unavailable. These three products contain Desiccated Natural Thyroid ‐ Thyroid USP (porcine). Many patients have tried other types of thyroid hormones, such as levothyroxine and liothyronine, and have found that Desiccated Natural Thyroid works best for them, reporting that they simply do not feel as well when they take levothyroxine alone or with liothyronine.
The theory behind the use of synthetic T4 alone (levothyroxine) is that the thyroid makes T4 which is converted to T3 elsewhere in the body. However, in some people, the conversion to T3 may be inadequate, and T3 is supplemented. Synthetic T3 (liothyronine) is commercially available only as an immediate acting preparation, which often causes undesirable side effects including heart palpitations. Therefore, some physicians have asked our compounding pharmacy to prepare a long‐acting form of T3. Many patients and their physicians have found that T4 (levothyroxine) and T3 (liothyronine) alone or in a combination using commercially available dosages have not worked adequately for them, but they have responded well to a blend of T4 and T3 that meets their physiologic requirements.
Saliva testing is a convenient, inexpensive, and above all, accurate means of testing steroid hormones. Scientific studies have shown a strong correlation between steroid hormone levels in saliva and the amount of hormone in the blood that is active or bioavailable. It is this fraction of total hormone that is free to enter the target tissues in the brain, uterus, skin, and breasts. Saliva testing IS FAST, ACCURATE AND COFIDENTIAL AND can be done anywhere anytime. In addition, hormones in saliva are exceptionally stable and can be stored at room temperature for up to a week without affecting the accuracy of the result. This offers maximum flexibility in sample collection and shipment.