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Home » R-Spondin 1 » R-Spondin 1 Proteins » Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein, CF
Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein, CF
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Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical ED50 is 8-40 ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt‑3a (1324-WN).
Applications Bioactivity
Carrier-Free
7150-RS-010/CF
7150-RS-025
Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein, CF Summary
Details of Functionality
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical ED50 is 8-40 ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt‑3a (Catalog # 1324-WN).
Chinese Hamster Ovary cell line, CHO-derived mouse R-Spondin 1 protein
Met1-Gln265
NP_619624
N-terminal Sequence
Ser21
Rspo1
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
<0.01 EU per 1 μg of the protein by the LAL method.
Bioactivity
40-43 kDa, reducing conditions
Read Publications using
7150-RS/CF in the following applications:
Bioassay
Lyophilized from a 0.2 μm filtered solution in PBS. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitute at 100 μg/mL in PBS.
Alternate Names for Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein, CF
Cristin 3
CRISTIN3
FLJ40906Roof plate-specific spondin-1
HRspo1
roof plate-specific spondin
RSpondin 1
R-Spondin 1
R-spondin homolog (Xenopus laevis)
RSPONDIN
R-spondin1
R-spondin-1
R-Spondin 1 (RSPO1, Roof plate-specific Spondin 1), also known as cysteine-rich and single thrombospondin domain containing protein 3 (Cristin 3), is a 27 kDa secreted protein that shares ~40% amino acid (aa) identity with three other R-Spondin family members (1, 2). All R-Spondins regulate Wnt/ beta-Catenin signaling but have distinct expression patterns (1-3). R-Spondin 1 competes with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors, Kremen and LRP-6, reducing their DKK-1-mediated internalization (4). However, reports are mixed on whether R-Spondin 1 binds LRP-6 directly (4-6). R-Spondin 1 is expressed in early development at the roof plate boundary and is thought to contribute to dorsal neural tube development (3, 7). In humans, rare disruptions of the R-Spondin 1 gene are associated with tendencies for XX sex reversal (phenotypic male) or hermaphroditism, indicating a role for R-Spondin 1 in gender-specific differentiation (7, 8). Mutations in R-Spondin 1 are also linked with palmoplantar keratoderma, abnormal thickening of the skin on the palms of the hands and soles of the feet (7, 8). Postnatally, R-Spondin 1 is expressed by neuroendocrine cells in the intestine, adrenal gland and pancreas, and by epithelia in kidney and prostate (9). Injection of recombinant R-Spondin 1 in mice causes activation of beta-catenin and proliferation of intestinal crypt epithelial cells, and ameliorates experimental colitis (9, 10). Interest in R-Spondin 1 as a cell culture supplement has grown with the expansion of the organoid field. R-Spondin 1 is widely used in organoid cell culture workflows as a vital component that promotes both growth and survival of 3D organoids (11). Structurally similar to other R-Spondins, R-Spondin 1 contains two adjacent cysteine-rich furin-like domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP-1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furin-like domains are needed for beta-catenin stabilization (2, 12). A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus (13). Mouse R‑Spondin 1 shares 98%, 94%, 94%, 93%, 92% and 88% aa identity with rat, human, horse, cow, goat and dog RSPO-1, respectively, within aa 21‑209.
Chen, J.-Z. et al. (2002) Mol. Biol. Rep. 29:287.
Kim, K.-A. et al. (2006) Cell Cycle 5:23.
Nam, J.-S. et al. (2007) Gene Expr. Patterns 7:306.
Binnerts, M.E. et al. (2007) Proc. Natl. Acad. Sci. USA 104:14700.
Nam, J.-S. et al. (2006) J. Biol. Chem. 281:13247.
Wei, Q. et al. (2007) J. Biol. Chem. 282:15903.
Kamata, T. et al. (2004) Biochim. Biophys. Acta 1676:51.
Parma, P. et al. (2006) Nat. Genet. 38:1304.
Kim, K.-A. et al. (2005) Science 309:1256.
Zhao, J. et al. (2007) Gastroenterology 132:1331.
Drost and Clevers. (2018) Nature Reviews Cancer 18:407.
Kazanskaya, O. et al. (2004) Dev. Cell 7:525.
Tomaselli, S. et al. (2008) Hum. Mutat. 29:220.
Wnt-4 Antibody
Applications: IHC, WB
SRY Antibody (1G4)
- BSA Free
Applications: CyTOF-ready, ELISA, Flow, IHC, IHC-P, WB
beta-Catenin
Antibody (12F7) - BSA
Species: Ch, Av-Du, Hu, Mu, Pm, Rt
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-P, IP, Simple Western, WB
SOX9 Antibody
Applications: ICC, Simple Western, WB
FOXL2 Antibody
NB100-1277
Species: Bv, Ma, Hu, Mu
Applications: ChIP, ICC/IF, IHC-WhMt, IHC, IHC-Fr, IHC-P, PEP-ELISA, WB
SF-1/NR5A1/Steroidogen ...
Dkk-1
5439-DK/CF
FGF-9
273-F9/CF
DAX1/NR0B1
Antibody (H7431)
PP-H7431-00
3266-RS/CF
Lgr5/GPR49
Antibody - BSA Free
Species: Hu, Mu, Po
Applications: Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, WB
LRP-6 Antibody
Applications: CyTOF-ready, Flow, WB
Kremen-1 Antibody
Applications: CyTOF-ready, Flow, IHC, WB
Splicing Factor 1
Antibody (2E12)
Applications: ELISA, ICC/IF, IHC, IHC-P, IP, WB
WT1 Antibody
(6F-H2) - BSA Free
Applications: ICC/IF, IHC, IHC-Fr, IHC-P, IP, Simple Western, WB
Wnt-3a
5036-WN/CF
Applications: BA, BA
Publications for R-Spondin 1 (7150-RS/CF)(8)
We have publications tested in 2 confirmed species: Human, Mouse.
We have publications tested in 2 applications: Bioassay, Cell Culture.
Showing Publications 1 - 8 of 8.
Publications using 7150-RS/CF
Z Fu, JW Dean, L Xiong, MW Dougherty, KN Oliff, ZE Chen, C Jobin, TJ Garrett, L Zhou Mitochondrial transcription factor A in RORgammat+ lymphocytes regulate small intestine homeostasis and metabolism Nature Communications, 2021;12(1):4462. 2021 [PMID: 34294718] (Bioassay, Mouse) Bioassay Mouse
K Dunbar, A Valanciute, A Lima, PF Vinuela, T Jamieson, V Rajasekara, J Blackmur, AM Ochocka-Fo, A Guazzelli, P Cammareri, MJ Arends, OJ Sansom, KB Myant, SM Farrington, MG Dunlop, FVN Din Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1 Cell Mol Gastroenterol Hepatol, 2020;0(0):. 2020 [PMID: 32971322] (Cell Culture, Mouse) Cell Culture Mouse
MW Dougherty, O Kudin, M Mühlbauer, J Neu, RZ Gharaibeh, C Jobin Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites BMC Microbiol., 2020;20(1):205. 2020 [PMID: 32652929] (Bioassay, Mouse) Bioassay Mouse
Y Cai, G Zhu, S Liu, Z Pan, M Quintero, CJ Poole, C Lu, H Zhu, B Islam, JV Riggelen, D Browning, K Liu, R Blumberg, N Singh, H Li Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation Cell Discov, 2019;5(0):7. 2019 [PMID: 30701081] (Bioassay, Mouse) Bioassay Mouse
Y Eriguchi, K Nakamura, Y Yokoi, R Sugimoto, S Takahashi, D Hashimoto, T Teshima, T Ayabe, ME Selsted, AJ Ouellette Essential role of IFN-? in T cell-associated intestinal inflammation JCI Insight, 2018;3(18):. 2018 [PMID: 30232288] (Bioassay, Mouse) Bioassay Mouse
G Greicius, Z Kabiri, K Sigmundsso, C Liang, R Bunte, MK Singh, DM Virshup PDGFR? + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 29559533] (Bioassay, Human) Bioassay Human
X Yin, H Yi, L Wang, W Wu, X Wu, L Yu RSPOs facilitated HSC activation and promoted hepatic fibrogenesis Oncotarget, 2016;7(39):63767-63778. 2016 [PMID: 27572318] (Bioassay, Mouse) Bioassay Mouse
Marie-Isabelle Garcia Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage Development, 2016;143(9):1452-63. 2016 [PMID: 26989172] (Bioassay, Mouse) Bioassay Mouse
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Additional R-Spondin 1 Products
Array 7150-RS/CF
R-Spondin 1 Antibodies
R-Spondin 1 Lysate
R-Spondin 1 Proteins
R-Spondin 1 Proteins and Enzymes
R-Spondin 1 ELISA
Bioinformatics Tool for R-Spondin 1 (7150-RS/CF)
Discover related pathways, diseases and genes to R-Spondin 1 (7150-RS/CF). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Diseases for R-Spondin 1 (7150-RS/CF)
Discover more about diseases related to R-Spondin 1 (7150-RS/CF).
Disorders Of Sex Development
True Hermaphroditism (disorder)
Gonadal Dysgenesis
Pathologic Neovascularization
Skin Neoplasms
Tissue Adhesions
Mucositis
Palmoplantar Keratosis
Ovotesticular Disorders Of Sex Development
Congenital Abnormality
Skin Carcinoma
Ovarian Failure, Premature
Pathways for R-Spondin 1 (7150-RS/CF)
Sex Determination
Gonad Development
Sertoli Cell Differentiation
Sex Differentiation
Female Sex Determination
Cell Migration
Osteoblast Differentiation
Insulin Secretion
Male Sex Determination
PTMs for R-Spondin 1 (7150-RS/CF)
Learn more about PTMs related to R-Spondin 1 (7150-RS/CF).
Blogs on R-Spondin 1
There are no specific blogs for R-Spondin 1, but you can read our latest blog posts.
SOX9 Antibody [Unconjugated]
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Gene Symbol Rspo1
NP_619624()


Yield hungry investors have swarmed syndicated leveraged loans this year. It seemed that they were throwing caution to the wind. Anything and everything seemed possible. Then came Rue21-one of the biggest high profile deals to flop in a while. Rue is a rapidly growing value orientated teen apparel fashion retailer. It has added 500 stores over the past years, and is scheduled to reach 1000 stores by year end.
In May, Apax, a UK private equity firm, offered to buy Rue for $1.1B Acquisition with a $62 Mln breakup fee. An affiliated Apax entity already owned 30% of Rue. The offer represented $42 per share- a 23% premium to market, 1.2X sales and 9.2X EBITDA. Comparable multiples were 0.5X sales and 8.4X EBITDA. The premium represented Rue's rapid growth potential.
Apax would contribute $280 Mln in equity with the balance financed by debt representing a FD/EBITDA multiple over 6X. The debt included a JPMChase, BofA and Goldman $530 Mln syndicated loan. The loan was richly priced at L+ 475 with a 1% LIBOR floor. During the syndication, Rue announced disappointing sales and earnings due to a "challenging retail environment". Same store sales fell 9.5% thru 3Q and by 12.8% in September. The syndication struggled, and the agents offered 20-25% discounts without success. See Syndication.
1) Aggressive leverage for a rapidly growing firm is always a challenge. Add in fashion retail and the margin for error is razor thin.
2) The purchase price was rich leading to the need for increased leverage. It only made sense assuming Rue's growth would continue.
3) Unexpected performance issues during the syndication are always possible. Nonetheless, I wonder how unexpected this really was. First, simple extrapolation, which appears to be the case here, is dangerous when constructing projections for growth firms. A modest downside case would indicate how problematic the debt service would be if a slowdown occurred.
4) Basic earnings quality analysis also suggested concern. Earnings are an opinion while cash is a fact. Despite Rue's growing sales and net income since 2009, their free cash flow peaked in 2011, and fell in FYs 2011 and 2012. Growth related, rapid CAPEX and inventory increases were part of the problem. This coupled with a performance decline suggests a) Rue must curtail its growth and b) Rue will have difficult time repaying its debt. Loan investors undoubtedly saw this, and declined to participate despite the original rich price and even with the substantial discount - they would not bite.
Diminished growth means the purchase price and capitalization rationales are no longer valid. Apax should consider renegotiating the deal or walking away after paying the breakup fee. The banks would be happy. Rue's current shareholders, of course, would be upset, but would still be $62 Mln richer. Discretion is sometimes the better part of valor.


2) During the period of hire, The Hirer (person named on contract) shall be solely responsible for the hired goods and insuring the goods if they feel necessary.
3) LES shall not be responsible for injury or damage to persons, buildings or property howsoever sustained arising from our goods under hire.
4) The contract for the hire of goods is between LES and the hirer, not the venue unless goods are being hired directly by the venue. It is the hirer's responsibility to ensure that the venue is clearly instructed so that the terms and conditions are met. LES will charge the Hirer for any costs due to terms and conditions being broken. It is then the responsibility of the Hirer to reclaim any of these costs from the venue or third party if the venue or third party was at fault.
5) We will not be held responsible for any circumstances that may occur to prevent us from carrying out this contract. If this should happen you will be notified and refunded in full. Compensation will not be due and under no circumstances will the owner's liability exceed the invoice value of hired goods.
6) All information including designs, colours and names for Table plans, place cards and other stationery items must be received by email to LES no later than one month prior to your date. If information is received later than this date we retain the right to use available stock and designs to fit the information we have on file for you.
7) Changes to orders within one month of your event date will be subject to availability and subject to an admin fee of £25+ vat.
8) Although we will try our best to get the closest match for any colours requested we cannot guarantee an exact match will be possible. We advise you to arrange a colour match prior to securing your booking as refunds will not be given for cancellations of any items where an exact colour match cannot be arranged.
10) A Safe unloading, loading and access area must be available for our staff whilst on site for all set ups and collections. If not available we will be unable to unload or set up for your event.
11) An adequate power supply must be provided for any electrical equipment hired. We deem it unsafe to daisy chain extension leads around a venue and will not do this. Refunds will not be given for items unable to be used because of inadequate power supply.
12) Terms and conditions are subject to change by Laceys Event Services at any time. It is the hirer's responsibility to check these terms and conditions on our website www.laceyseventservices.com for any updates or changes.
1) A 50% Deposit of each item is required to secure our services and products. Your order is not secure until we have received cleared payment of this deposit. If payment is being made by instalments or cheque your booking will only be secured once cleared payment of the 50% deposit has been received. As we are limited to the amount of events we can take on in any one day this deposit or part payment of any deposit is completely non-refundable.
2) The final balance is due one month prior to your set up or dispatch date. If you fail to pay your balance by the required date, we reserve the right to cancel your order and in the event that another event wishes to book for that day, they will take priority if a deposit has been received from them.
3) Cancellation by the hirer will result in the forfeit of the deposit and any monies paid. This applies to complete orders and individual items on your order.
4) Full balance will be due for cancellation by the hirer of any events within one month of event date.
5) Changes in numbers can be accepted up to one month prior to your date. Final numbers and order details must be confirmed no later than one month prior to set up or dispatch date. Any changes at all including changes to set up and collection times after this stage will be subject to availability and will incur a £25+ vat administration fee.
6) A £150 or 10% Refundable Security Deposit, whichever is greater, is payable in addition to the hire charges on all hire bookings, to cover minor shortages and damages to hired goods. This will be due for payment one month prior to your event and will be returned once all hired stock has been checked back in at Laceys. This invoice constitutes part of your order and failed payment of this invoice will result in cancellation of your order and set up.
1) All products are counted and checked by LES at time of set up. In the event of shortages or damages that may be overseen by LES, the Hirer shall notify LES within 24 hours of delivery. If the Hirer fails to do this, The Goods will be deemed to be delivered in correct condition.
2) Charges will be made for any damaged goods. This includes but is not limited to; goods that have been dragged on the floor, ground in earth or grass stains, biro, burns, holes, rips, tears, candles wax, grease or deep staining.
3) Candles supplied with Candelabras are not intended to be lit. If you wish to use candles please ensure you supply and use Non Toxic, Non drip or LED candles. Charges will be made for any candelabra returned damaged, dented, permanently tarnished or covered in melted wax.
4) You are not permitted to use any flowers, artificial or fresh, other than those supplied and set up by Laceys Event Services Ltd on our candelabras and vase-ware. Charges may apply if they are.
5) Shortages and damages to hired goods will be charged at full replacement value plus VAT and delivery to LES. No substitute item will be accepted by LES.
6) LES will inform The Hirer within 14 days, in writing of any damages or missing items on the order. The hirer has 7 days from the date of notification to return any missing goods. After 7 days LES will deem any goods not received back as missing and charge at full replacement cost plus VAT and delivery to LES. Any charges will be deducted from the refundable security deposit or where value exceeds the refundable security deposit an invoice will be issued to the hirer.
7) Additional courier charges or additional journeys for attempted re-collection will be charged at full mileage plus time.
9) Invoice will be due for payment within 14 days. Failure to make payment will incur a £25 + vat late payment fee. Invoices still not settled within 30 days of issue will be sent to an external debt collection agency with fees of £150+ being added to the account to cover costs.
1) Goods must be ready for collection at the agreed location at the correct date and time. A charge is made for an aborted delivery/collection by the courier and/or LES where the venue/hirer/customer is at fault.
2) DIY Orders: Goods must be packed in the boxes they were delivered in. If there is more than one box, the items should be divided equally between the boxes to stay within specific Courier weight limits. Charges made by Courier for incorrect weights will be deducted from the Security Deposit.
3) All hired items including chair covers and table linen must be removed by the hirer prior to collection. An additional fee will be charged if Laceys Event Services arrive to collect and need to remove covers and linen from tables and chairs.
4) Any furniture including Tables and chairs must be laid out in place prior to our arrival. LES will not lay out chairs and tables unless previously arranged between the hirer and LES with confirmation in writing.
If LES arrives at venue and tables and chairs are not laid out ready, we retain the right to leave items at venue for the hirer to set up or charge an additional fee for this service at our discretion.
5) If hirer is using table linen from another company other than LES they will need to ensure that table linen is ready at the venue & on the tables prior to our arrival. If linen is not available and tables cannot be set up then LES retain the right to leave items being placed on top of linen to one side for set up by the hirer or third party ready for when linen has arrived. At LES discretion and if timings allow LES may be able to wait for linen to arrive but additional fee will be charged for the waiting time for each staff member of £25 + VAT per hour or part thereof.
1) Cutlery, glassware & crockery hire is on a return clean basis unless mentioned otherwise above. Any items returned dirty will be charged for cleaning.
1) Indoor Carpet Aisle Runner is for indoor use as an aisle only. Use outside or for any other purpose than that of a wedding aisle will result in deep cleaning charges or full replacement cost being charged to the hirer.
1) Starlight Backdrop is not to be positioned within 3ft of any dance floor or dancing area. At time of set up if the requested position of Backdrops is within 3ft of a dance floor or dancing area the contact at the venue at that time will be able to advise an alternative position or if no alternative is available the backdrop will not be set up. No refund will be due if no alternative position is available.
2) It is the hirer's responsibility to ensure that all dimensions, colours and fabrics for drapes and canopies are correct at least one month prior to event date. LES assumes no responsibility for incorrect measurements resulting in insufficient fabric for drapes/canopies or insufficient equipment brought along as a result of incorrect dimensions including heights.
3) It is the hirer's responsibility to check with the venue owners and obtain permission for any fixing of made to measure drapes, swags and canopies. This includes but is not limited to checking if venues are listed buildings. Refunds will not be given in full or part if we are notified upon arrival that permission has not been granted. Nor will we will be responsible for any damages invoices issued by the venue.
4) For erection of ceiling canopies a clear floor space is required, it is up to the hirer to ensure the area is clear prior to our arrival unless otherwise agreed with LES in writing due to health and safety / work at height regulations. If area is deemed as unsafe or unclear at time of arrival LES will not erect the canopy. In this instance a refund will not be given.
5) It is the hirer's responsibility to provide a full and detailed floor plan indicating entrance ways and fire exits prior to LES set up. Unless a site visit has been booked and paid for by the hirer and then it is the responsibility of LES.
6) It is the responsibility of the hirer to ensure there are ample electrical sockets for the use of any lighting and backdrop equipment.
1) For stationery items and invitations ordered in separate batches or at different periods of time we cannot guarantee exact colour matches of card, ribbon or ink stocks. This includes but is not limited to samples. We use the same regular supplier for all of our materials but as with all products batches vary so you may see slight colour variations in this instance.
2) Although we will try our best to get the closest match for any colours requested we cannot guarantee an exact match will be possible. We advise you to arrange a colour match prior to securing your booking as refunds will not be given for cancellations of any items where an exact colour match cannot be arranged.
3) All of our bespoke and handmade items are non-refundable (Unless faulty). This includes but is not limited favours, invitations, bouquets and bridal flowers, stationery. Goods can be crafted immediately from the point of sale so under no circumstances will refunds be permitted on such items unless faulty.
4) Any damages, faults or missing items must be advised to LES within 24 hours of delivery. After this period goods will be deemed accepted.
5) Where goods are booked with us on a supply only, DIY or purchase basis we will send products by signed delivery. We will not be held liable in any situation where goods are dispatched from our premises and not delivered (or delivered late) by the carrier. We can supply full details including proof of dispatch and contact details for the carrier used but will be unable to refund or compensate or assist with obtaining compensation from the carrier in this instance.
1) As fresh flowers and foliage are living products, there are occasions when particular varieties may be unavailable. Whilst every effort is made to source products accordingly, sometimes we are unable to obtain a particular flower type. All fresh flowers and foliage are subject to availability on the date we order them from the Dutch flower auctions and stringent quality checks, as such LES reserve the right to use a similar flower in the place of your previously chosen flower.
2) We Order your wedding flowers approximately 10 to 14 days before your wedding date, dependent on type of flowers chosen. You will not be allowed to make any changes after the order has been placed without additional fees being incurred. These fees will have to be paid in full before any changes can be submitted and ordered for you. We will however make small changes where possible to accommodate your needs.
3) Mock Bouquets and designs can be made for you to view and they will be made to the same high quality of your actual bouquet or design, as such they will be charged at the full cost of display. Payment will need to be received before fresh flowers can be ordered.
1) No Tables, chairs or furniture are to be placed on dance floors hired from LES. Any damages as a result will be charged at full replacement cost of each panel damaged or permanently marked.
2) Liquid spillages on the dance floor can occasionally result in component failure. The hirer is liable for any damage caused and replacement costs.
3) The surface where the floor needs to be laid must be flat and dry. An uneven floor may result in the LED's not working as panels cannot connect properly. Our staff will not lay the floor on a wet surface as this will damage the panels. No refunds will be given if dance floor cannot be laid due to the surface being wet or uneven.
4) The venue must have suitable access. The dance floor is in large flight cases weighing around 200 kg each so cannot be taken upstairs, steps, over grave or ledges. Where the function room is upstairs a suitable goods lift must be accessible for use.
5) If the access is poor and does not adhere to the above points there will be an additional charge to cover extra time or staff allocated to your event to carry panels into the venue by hand.
By securing your date by deposit you have agreed to be legally bound by this contract. If you do not agree to be legally bound by this contract then you have 7 days from the date of this contract to cancel your order. To cancel your order we must be notified by post or email on the below details only and you must have received an acknowledgment from Laceys Event Services. By acknowledgment you will receive a refund of your deposit and a written receipt. Bookings made where delivery is required within the next 30 days are agreeing that no cancellation period is permitted.


text:
Why Women Aren't 'Equal' Yet
by Jessica Eggert
Many anti-feminists are fed-up with the modern feminist movement. These people feel that women have fought and earned the equal rights they desired and are now just power-hungry. Being a woman myself, I know that isn't true. There is no doubt that women are still fighting for equality. In 2009, full-time year-round working women earned 19% less than did men. This gender income disparity is only increasing.
While the feminist movement has earned women equal rights and opportunities in our legislative system, it has not yet achieved equality for women. Women are still discriminated against in society. As many rights as women have earned, it is difficult to completely eradicate stereotypes that cause people to look down on them.
I say people and not just men for a reason. The truth is that, whether we realize it or not, we women tend to also believe stereotypes about ourselves that prevent us from achieving certain goals. Women are still, to an extent, seen as the submissive sex and not as strong or as smart as men. Because these stereotypes have existed for so long, women subconsciously believe them. These ingrained biases still prevent women from taking risks in their careers and speaking up for themselves when it comes to sex or relationships.
The sociological term for this is "stereotype threat" and it has been proven to prevent women from being as successful as men in certain areas. According to a study from the University of Michigan, women underperformed on a math exam when they were told that men usually perform better. On that same test, when women were told that men do not have better results, they performed just as well as the men did.
We all know the infamous line from "Sandlot," "You play ball like a girl!" Well, what if that girl played ball like a pro? We need to stop screwing ourselves over by letting these stereotypes hold us back. What was the first thing your mother told you when you came home from pre-k upset that the boy you wanted to marry called you stupid? Sticks and stones may break your bones, but words may never harm you. Ironically enough, they are harming us the most.
In this day and age, we can do whatever we want as long as we believe we can. Men are still statistically superior to women in their careers because not only do they believe they can do it, but they believe they can do it better than women. After all, that's what they've been told. They have the stereotype on their side.
Think about it this way: living in America, we are lucky enough to have received an equal education to men and the law protects us in our pursuits of happiness and success. In other countries, as sickening as it is, women are still fighting for what we consider basic rights. So let's stop being intimidated and start feeling equal rather than inferior. Fight past the stereotype; something men never had to do.
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How Being A Capricorn Rising Sign Affects Your Personality & Love Life
By Mackenzie Sylvester
65 Friday The 13th Captions That Are Creepy And Witty To Their Core

redpajama_set_name: RedPajamaCommonCrawl


text:
From 'Foreign Language' To 'International Feature': Why A Change In Name Isn't Enough
Posted on February 5, 2020 June 22, 2020 by Sophie Butcher
This article was written exclusively for The Film Magazine by The CineBlog's Sophie Butcher.
The countdown is on – the 92nd Academy Awards are days away, and the seemingly endless awards season discourse will soon be at an end for another year.
It's almost a century since the Oscars began. Despite its best efforts to diversify, including inviting swathes of new members to join the Academy, the biggest awards ceremony in the cinematic calendar still can't seem to get it right. One of the most notable changes for the 2020 awards is the renaming of the category previously known as 'Best Foreign Language Film' to 'Best International Feature Film'.
So – why the change?
As reported in this Screen Daily article, co-chairs Larry Karaszewski and Diane Weyermann have said that calling the films in this category 'foreign' is 'outdated' and 'can be taken as alienating', and that the name was changed so as to 'reflect the inclusive and universal nature of cinema'. The intention is applaudable and the decision to remove the word 'foreign' is certainly a good one, given that its application depends on your perspective – as Alfonso Cuaron reminded us during one of his acceptance speeches last year. But, whether the change actually moves the dial on inclusivity is still up for debate.
The title of 'Best International Feature Film' may be new, but the criteria for the category isn't changing; according to the rules for this year's awards, 'An international feature film is defined as a feature-length motion picture produced outside the United States of America with a predominantly non-English dialogue track'. What's confusing is, those are really two separate things, and it means films from underrepresented countries and communities are falling through the cracks.
This year saw the submission of Lionheart, the first ever from Nigeria, in the new International Feature category. The film was disqualified on the grounds of being ineligible, with only eleven minutes of its runtime being spoken in non-English dialogue. This caused a fair amount of backlash – director Genevieve Nnaji spoke about how the use of English in the film acted as a way of connecting the 500+ dialects of her country, and that the film is still 'proudly Nigerian'. She had support from prestigious filmmaker Ava DuVernay, who tweeted the Academy asking why they had punished Lionheart when English is actually Nigeria's official language.
This is a case in which the two-pronged nature of the International Feature criteria is working against a film, and limiting the inclusion that the Academy are purportedly aiming for.
Nnaji, when talking about the context of the use of English in the film, also stated that 'We did not choose who colonised us'. This speaks to the political core of this issue, and what the Academy really mean when they decide which films qualify for Best Picture versus Best International Feature Film. The lack of clarity in the awards criteria leads to an unavoidable double standard, and when it comes to the rule around being produced outside of the US, we never see British films like The King's Speech, Atonement, or this year's 1917 moved into the International category – though, by the Academy's own logic, that's exactly where they should be.
Is it a bias in favour of the Western world that means British films get to compete with the big boys when others don't have the chance? Or is it just a preference for movies that are largely White? Defining the International Feature category by these two very different elements inevitably results in judgements made against some films, and allowances made for others. The playing field isn't clear, and is nowhere near level.
Judging from its hype, critical acclaim and awards success so far, it looks like Bong Joon Ho's Parasite will become the first to win this newly titled award. The South Korean masterpiece is also one of the very few films to have been nominated in both this category and for overall Best Picture since the birth of the Oscars in the late 1920s, and the introduction of the Foreign Language award two decades later.
Parasite aside, only five others have managed this – the Algerian-French epic Z (nominated in 1970); the Italian film Life Is Beautiful (nominated in 1999); Chinese martial arts masterpiece Crouching Tiger, Hidden Dragon (nominated in 2001); French romance Amour (nominated in 2013); and last year's Roma, from Mexico. All five have something else in common – they all won in the Foreign Language category, but none ultimately took the Best Picture crown.
Somewhat of an outlier in this conversation, but also worth considering, is The Artist. It wasn't nominated in the Foreign Language category, and was a surprise Best Picture win. Ostensibly a French film, but also a silent one (without any dialogue), it seems to have dodged the double-nomination bullet thanks to its lack of any audible language at all.
The fact that so few films have been able to bridge both categories, and that they are never able to take home the biggest Oscar of all when they do, begs the question – how do the two categories relate to each other in terms of quality? Is only one Foreign Language film able to break into the Best Picture list at a time? It's surely extremely short-sighted to suggest that only one non-American film has ever been good enough to be shortlisted each year – and yet, there seems to only ever be a single spot for their recognition, on the rare occasion it happens at all.
It would almost make more sense for the two categories to be completely separate, with no crossover possible; instead, we have the potential for international films to be 'good enough' to work their way into Best Picture nominations, implying that the American films taking up most of the space in that category are inherently 'better'. If winning both categories is possible and we simply haven't seen a film yet that is worthy of both honours (though that seems unlikely), then surely Parasite is the one to break the mould?
Perhaps we should accept that the Oscars are an American institution, and, just like the BAFTAs (supposedly) prioritise British filmmaking, the Academy may do the same for movies made in the US. But, with no divide between international and American talent for any other award than Best Picture, this discretionary separation of films between these categories looks to be a way of keeping non-White, non-Western, 'foreign' work on the periphery of success.
Here's hoping Parasite wins on Sunday night; that it sweeps the board. Here's hoping we see Bong Joon Ho collect those little statues for International Feature, Directing, Best Picture and more. This debate only serves to remind us how little awards really matter in the grand scheme of great cinema, but victory for this weird and wonderful film would be as sweet as the peaches that make it so iconic.
Sophie Butcher
Contributor at The Film Magazine
Sophie Butcher (She/Her) is a film and TV writer living way up North. Big fan of neon, great movie kisses and anything with Keanu Reeves.
Latest posts by Sophie Butcher (see all)
Our Ladies (2020) GFF Review - March 6, 2020
Birds of Prey (2020) Review - February 10, 2020
From 'Foreign Language' To 'International Feature': Why A Change In Name Isn't Enough - February 5, 2020
Posted in Essays, Features, Latest Posts, Sophie Butcher, The Oscars	Tagged academy awards, academy of motion picture arts and sciences, essay, feature, foreign language film, international feature film, lionheart, oscars, parasite, sophie butcher, the oscars
In the Absence – Oscar Nominated Documentary Short Review
2020 Oscars Best Picture Nominees Ranked


My name is Ashlee, I am 27 years old and from California. At the age of 25 my husband and I received some exciting news, we were expecting a baby! We couldn't be happier. 25 was a great year we did a lot of traveling, ran a half marathon, and now having a baby; life was great!
Around 10 weeks along I started getting bad headaches, bloody noses, couldn't hold anything down, and also had weird rashes all over my body. I called my OBGYN and they told me to take some time off work, just relax and take some nausea medicine. Still feeling ill, I went to a walk-in doctor who diagnosed me with a viral infection.
Two weeks have passed and I was getting worse. I was at the point where drinking water or Gatorade made me sick. We went to our local ER and they drew some labs, something was abnormal so they thought maybe the test was inconclusive. They drew my blood once again. Same thing, something was wrong. After two ER doctors checking me out, talking to me and not being able to figure out what was wrong, they thought the best option was to transfer me to Stanford Medical Center which was 3 ½ hours away.
I was transferred via ambulance, and had 5 teams of doctors upon arrival, including: Kidney, OBGYN, Hematology, Dermatology and Primary doctors. That first day was all a blur. I had test after test done. I had platelets of 13, hemoglobin 7, kidney failure, high calcium levels and this rash. All the labs were looking like I had leukemia so they did a bone marrow biopsy. I had X-rays, ultrasounds, MRI and tons of tests done. The rash ended up being eczema which I had never had before. After the bone marrow biopsy came back negative, and blood levels getting worse, they started treatment for TTP. 'What is TTP?' we were all thinking, I had never heard of this before! That is all I could think about the first day starting treatment.
I was being treated by plasmapheresis, and high doses of prednisone. I was starting to feel better and my platelets were looking better. Being at a teaching hospital, my hematology team switched doctors. The new doctor wanted to stop plasmapheresis for a day: Thanksgiving. That afternoon, I started to feel sick; platelets began to drop and treatment began again.
After 17 days in the hospital, I was released to outpatient treatment. We had to stay in the area as where I live, the treatment I needed was not available. Treatment was every other day, or every three days. Lab work was still done daily.
I went in for my 16 week ultrasound to find out there was no heartbeat, just when we thought things were looking up. After recovering from losing the baby, we were up there for another two months. It was quite the scare and quite the journey. I was told this could come back in future pregnancies, and we still have yet to find out if it was congenital or acquired. I had a genetic test and there were some abnormalities, but none that could determine. My adamsts13 has always been low, and is still low a year later. My spleen is still slightly enlarged as well. Some of the hematologists think it was acquired, some think congenital. We do know it was pregnancy induced.
This definitely has changed our lives and our thoughts on becoming pregnant again. We still go back and forth about wanting to try.
I can now live my life normal, but I still feel like my body is not as strong as it was when it comes to working out, hiking, and the other stuff I did before I became sick. I now try to host as many blood drives as I can and try to bring awareness to this disease.
In total I had about 21 treatments which is equivalent to around 220 blood donors. I not only had plasma, but I also had red blood cells and platelets transfusions.
"The mild/moderate headaches, light sensitivity and lightheadedness continued and intermittently, my heart would begin to race for no apparent reason."


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This Weekend In Oshkosh: Clawhammer
Chris Schlarb is not an artist who likes to take the easy way out. His forthcoming album, Psychic Temple II, is conceptually and musically complex. But as attracted as he is to complexity as a bandleader, his planning as impresario of the forthcoming Clawhammer Music & Arts Festival, July 20-21 in Oshkosh, Wisconsin, was hardly less elaborate.
The festival started as an invitation to perform, from Oshkosh-based Schlarb collaborators Nathaniel Frank & the Wisconsin Magic. But, Schlarb says, "I'm bringing out like a six piece band," an expensive proposition for a concert presenter. "So I said, why don't we do a festival, and make it a bigger event? Get the community involved, instead of just putting on a show."
And the Clawhammer Festival was born. Starting with Frank, "I started getting in touch with musicians and bands that were both regional and bands that I liked," Schlarb explains. "I wanted to put together a music festival that I would want to attend." That meant not only a wildly eclectic lineup, but also "good food, a great environment, and also some visual artists."
"Normally outdoor festivals have terrible sound, and you're standing in the sun—for me," Schlarb says, "that's not the way to experience music." In Oshkosh, "They have this beautiful masonic temple there that they're refurbishing, and they wanted a big event as kind of a coming-out party to establish the masonic temple as a place for artists to come by and play." It was perfect for Clawhammer: "Performing on a really old stage as an artist can also be inspiring creatively. It brings more out of you as a perfomer."
The visual artists were brought onboard by reaching out to the local community. "There's a guy named Eric Anderson, who's an artist in Oshkosh—he was brought in by Nathaniel Frank," Schlarb says. Frank "gave Eric the leeway to get in touch with people in his community, to bring them into the festival."
For the festival's musical acts, "I was able to put out a few calls to Asthmatic Kitty artists who were relatively close by," he says, such as Liz Janes—with whom Schlarb will share the stage—and teenaged sister duo Lily & Madeleine. But "I didn't want it to be like a jazz festival or a folk festival," says Schlarb; "I just really liked the idea of all these artists watching each other's shows and experiencing a genuine sense of community."
Outside the Asthmatic Kitty family, Schlarb says, "One of the things that's really exciting to me is that R. Stevie Moore, who's been making music since the '60s, is going on before Lily & Madeleine, who were probably born in the '80s or '90s." He's thrilled to meet Moore, and to imagine what he and the sisters might be able to teach each other.
The rest of the lineup features the Haunted Heads; Attack, Octopus; All Tiny Creatures; deeply Midwest-rooted "high-concept hip-hop artist" Serengeti; and Joseph Huber, formerly of the "streetgrass" .357 String Band.
For Schlarb, the mention of banjo-playing Joe Huber brings to mind the numerous meanings behind the name of the festival: "There's a style of playing called clawhammer, and the name Oshkosh means 'claw,' and then there's this Captain Beefheart song called 'Clawhammer'…" It's a web of signifiers that wouldn't seem out of place on his latest record.
"The antidote to being cynical is to be truly experimental," says Schlarb. He sees experimentalism as "a sign of respect" to his Oshkosh audience: "Let's try to really inspire each other, and hopefully that will inspire the community to come out and support the festival."
About Lily & Madeleine
There's something inherently incongruous about the music of Lily and Madeleine Jurkiewicz, a pair of slight teenagers with singing voices this assured and worldly. Their music sounds like something out of another age, not the work of a pair of sisters born less than two decades ago.
About Liz Janes
Liz's music ebbs and flows, bubbles out baroque passages, and envelops the listener in electronic warmth and cosmic analog sound, horns a-blazin', drums a-tishhking, Rhodes piano a-Rhodesing.
Psychic Temple II
Psychic Temple II is a labor of love envisioned by Chris Schlarb to bring his most far-ranging inspirations to life – as he puts it, "a dream ensemble that could never actually exist."
CD $10
LP $15


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+maliciously replaced at any given time in the future.
+sensitive details, are all blocked from merge.
+without having to touch any code.
-Provides exception / waiver lists to whitelist files, data.
+extra layer of security review with the ability to block a patch merge at gate.


John Ibbitson is a CIGI senior fellow, effective January 2014. An award-winning writer and leading political journalist in Canada, John will research, write, and speak on Canadian foreign policy at CIGI, while on a one-year leave from The Globe and Mail.
Critics of Harper's foreign policy would do well to remember that those policies aren't meant to appeal to you, argues John Ibbitson.
John Ibbitson looks back on Jim Flaherty's tenure as finance minister and his great achievement of showing the world how a nation should manage its finances.
The old debate over Quebec's place in Confederation has very little relevance to Canada's economic future or the people chasing that future, argues John Ibbitson.


The Halgan Plaster Trap is used to trap plaster and other fine material in the waste water prior to discharging to the sewer system. The removable basket has an arrangement of weirs and deflectors to maximise the trapping of particles.
The Plaster Trap is designed to be fit under benches, which will reduce installation costs and provide easy access for servicing.
The Halgan Plaster Trap is manufactured from 304 grade stainless steel. The basket material is stainless steel. Wall thickness is 1.6 mm.


It can be very difficult to find straightforward, easy-to-understand online advice about fitness programs. The sheer volume of available information can overwhelm you, and leave you wondering if you will ever get around to actually exercising. Fortunately, you can take a look at this article to pick up some handy tips you can put into practice immediately.
A personal trainer is a good idea when you are new and clueless to working out. A good one will discuss your goals, as well as your problem areas, to determine the best workout plan for you. Although your first gym session can be scary, you can breeze right through it by hiring a professional to get you started. This will get you into the swing of things very quickly.
TIP! When you have a specific set of objectives leading to a goal, you will have built in motivation for your fitness plans. This encourages you to focus on overcoming obstacles instead of obsessing over their difficulty.
Pick an exercise that is fun and you will be more likely to stick with it. If you are doing an activity you enjoy you will start to look forward to your work outs.
Are you short on time? Split your workout time into two halves. Don't increase the duration of your workout, just do it in two portions. Run during the morning and evening for 30 minutes, rather than running for a one full hour. You can do two different types of workouts if you want, which will help to keep things fresh.
In order to avoid hitting the fitness center twice in the same day, you might try getting one workout in at the fitness center and then doing another one elsewhere.
TIP! Choose an exercise program that tones your muscles as well as offers flexibility exercises. Look online and see if you can find classes in your neighborhood.
Counting calories is helpful when trying to lose weight. By counting the calories you consume each day, it can help you lose weight. When you only use calories at your level of maintenance or lower, and you lose some while you exercise, you will find you are fitter sooner.
Push-ups are great and simple way to add a nice tone to your triceps. To isolate the triceps, bring your arms and hands close to your body and bend your arms back, rather than out to the sides, as you lower into your push-up. This particular pushup tones and strengthens your triceps more effectively than other types of exercises.
Try thinking out of the ordinary when you want to start a new fitness program. There are many activities out there that offer a great workout and do not involve going to the gym. Picking a workout regimen that you actually enjoy will continue to give you the motivation you need.
TIP! Never make the mistake of sticking with the same workouts each time you work out. This will keep you focused and motivated so you keep coming back for more every day.
Maintain proper posture when walking, as this can prevent injury. Stand straight and put your shoulders back. Allow your elbows to fall at about a 90-degree angle. When you are walking, the arm that is in front of your body needs to be on the opposite side of the foot that is in front. So if your left foot is in front of your body, your right arm should be as well. Your heel should always touch down first. Let your foot roll forward naturally and push off with your toes when you start your next stride.
Scheduling your exercise can help you avoid making excuses and ensures that you work out frequently and regularly. Try to exercise a certain number of days every week, and stick to your schedule as much as possible. If you cannot avoid missing a particular day's workout, reschedule it for another day and approach it with the same level of commitment.


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Kaduna Guber: Ashiru, PDP Move To Dethrone El-Rufai, Seek Recount Of Ballot
Posted by Mr Ejump on May 15, 2019, Under: 9ja news
The governorship candidate of the Peoples Democratic Party (PDP) in the 2019 general elections, Isah Ashiru, on Tuesday, filed an application seeking for a recount of the votes cast during the March 9 governorship polls.
Ashiru's counsel, Elisha Kurah (SAN), submitted the application to the Justice I. M Bako-led tribunal that commenced pre-hearing session in Kaduna.
Justice Bako, however, adjourned the session to May 25 to allow the Independent National Electoral Commission (INEC) and the two other respondents in the petition time to respond to the PDP's application on votes recount.
Kurah who spoke to journalists shortly after the adjournment of the session urged the tribunal to order INEC for the recount of the votes cast.
He explained, "We filed an application requesting to recount the votes cast during the election.
"It is very crucial as we are alleging which is supported by the evidence we have that most of the results declared were phantom votes.
"They were back up by votes in the ballot boxes. So we want a complete recount of the votes cast in the governorship election.
"We are expecting that the results would show that the PDP actually won the election.
"But votes were just inflicted randomly just to make the APC have the semblance of winning."
Counsel to PDP, Ibrahim Bawa (SAN), told newsmen that he also filed an application seeking that certain paragraphs of the respondents' responses to "our application be struck out for lack of merit."
Meanwhile, Abdulhakeem Mustapha, Counsel to Gov Nasiru El-Rufai in a separate interview with newsmen said, "The petitioners of the PDP and its candidate, Isa Ashiru have four highly contentious applications.
"And we intend to oppose the applications on their merit. And the tribunal has given us a new date for us to come and argue the applications. So, the matter is adjourned for hearing of all the pending applications.
"We have a preliminary objection that the petition is not competent. They (PDP and Ashiru) have an application that they want the tribunal to direct that the ballots be counted one after the other in open court, and we intend to oppose those applications."
According to him, the Electoral Act is in our favour, the Kaduna people have spoken. They picked Mal. El-Rufai and nothing is going to change that.
"We are here to defend the mandate the people have given to the governor. We intend to convince the tribunal that the petition lacks merit and it should be dismissed," Mustapha said.
Source:- Dailypostng


We analyze and show interconnections between prox subgradient and dual averaging methods for both sequential decision making as well as non-smooth convex optimization. Our sequential decision-making problem context generalizes the allocation problem addressed in the Hedge Algorithm as studied by Baes and Burgisser.Furthermore, our framework provides a new interpretation and extensions of the algorithm AdaBoost, where the distribution on examples provides the primal variables and the final classifier arises naturally as a weighted average of dual variables. Lastly, we examine connections between various first-order method, and propose new first-order methods as well.
We present a "kernelized'' variant of a recent family of approximate dynamic programming algorithms we have dubbed "smoothed approximate linear programs''. Our new algorithm is non-parametric in that it does not require a basis function architecture and develops a value function approximation with accuracy that improves with the size of the training data set. We describe the efficient implementation of this method, and present sample complexity bounds and approximation guarantees that effectively extend state of the art guarantees for ADP to the non-parametric setting. In summary, we believe this is the first practical non-parametric ADP algorithm with performance guarantees.
We analyze a class of estimators based on convex relaxation for solving high-dimensional matrix decomposition problems. The observations are noisy realizations of a linear transformation X of the sum of an (approximately) low rank matrix Θ\star with a second matrix \Gamma\star endowed with a complementary form of low-dimensional structure; this set-up includes many statistical models of interest, including factor analysis, multi-task regression, and robust covariance estimation. We derive a general theorem that bounds the Frobenius norm error for an estimate of the pair (Θ\star, \Gamma\star) obtained by solving a convex optimization problem that combines the nuclear norm with a general decomposable regularizer. We specialize our general result to two cases that have been studied in past work: low rank plus an entrywise sparse matrix, and low rank plus a columnwise sparse matrix. For both models, our theory yields non-asymptotic Frobenius error bounds for both deterministic and stochastic noise matrices. Moreover, for the case of stochastic noise matrices and the identity observation operator, we establish matching lower bounds on the minimax error.


Schools form the essential fabric of society, they are houses of learning, growth and development for young minds. Small wonder then, that students like to keep the memories from those years in the form of yearbooks. School yearbooks have preserved memories of those cherished times, a record of accomplishments, growth and relationships in the school yearbook pictures.
However, school yearbooks until now have been heavy, cumbersome paper books that are difficult to produce, distribute and store. And to top it all, they are also very expensive. Besides, once purchased, they are browsed through for a short time before they are relegated to storage. Most often, they are stored either on a book shelf or they find their way into the family attic, only to be forgotten. Which is an irony, since they were purchased with much enthusiasm.
But what's the alternative to the traditional yearbook?
Introducing SchoolFlicker, the paperless yearbook.
SchoolFlicker is a school yearbook like no other. It ushers the yearbook into the digital era and heralds an entirely new era for the school yearbook. Everything else has gone digital, shouldn't the school yearbook as well?
SchoolFlicker offers the perfect solution to the cumbersome, difficult to produce and expensive paper yearbook. It is completely digital and comes with exciting new features, transforming the traditional, dull paper yearbook. SchoolFlicker offers far more than just high school pictures with a few words of text, it offers audio and video as well. Imagine how the addition of sound and movement can make profiles and school events come alive and stay alive in people's minds. That is the magic of SchoolFlicker.
So now, SchoolFlicker makes the yearbook accessible at any time, any where. It is available literally at the tips of your fingers, via your mobile phone. It is also available via the web. This yearbook will never languish on a dusty bookshelf, nor will it remain boxed in the attic. Imagine being able to access the digital school yearbook, any time, any where. Imagine being able to relive those memories any time you need to, being able to see your friends and keep those relationships fresh in your mind.
Now, it is all possible, with SchoolFlicker, the paperless yearbook!
And those are not the only advantages for a school.
There are so many more advantages to going digital with the school yearbook than the ones mentioned above. Schools by their very nature are houses of learning and education. The traditional yearbook takes a school's time away from their core competency, that of imparting an education. The traditional yearbook requires time and effort on the part of a school. The process of planning, creating and distributing the yearbook is complex and time-consuming. And then there is the issue of unsold inventory creating headaches for a school's authorities.
All these problems are eliminated with SchoolFlicker, which is easy to produce and saves a school time, money and effort. Entirely digital, SchoolFlicker does not require major investment on the part of any school. There will be no excess inventory to worry about.
Another advantage of SchoolFlicker is that it makes parents happy. SchoolFlicker costs far less than the traditional paper yearbook, saving parents a considerable amount of money. Each traditional yearbook can cost between sixty and a hundred dollars. The burden on parents is more when they purchase multiple school yearbooks each year for more than one child. Small wonder, then, that parents are happy to go digital and embrace SchoolFlicker wholeheartedly.
SchoolFlicker is also environmentally friendly. It uses no paper and therefore saves trees. This fact is of particular interest to those that are looking for eco-friendly products. The younger generation tends to be conscious of the environment and going digital will be of particular interest to them because of their involvement with the environment. There is also another reason they are happy to embrace SchoolFlicker. The younger generation is also more likely to be aligned with technology which makes it doubly easy to please them with SchoolFlicker.
Yes, the era of the paperless yearbook is here, offering so many advantages to schools, to students and to parents. With all these advantages stacking up, there's every reason to choose SchoolFlicker. Move away from the traditional yearbook and enjoy the completely digital advantages of the paperless yearbook from SchoolFlicker!
Create virtual memories with SchoolFlicker, the paperless yearbook!


Suppliers for Japan's top three auto companies were alerted last week about production plans for the fiscal year that begins April 1 and the news was surprisingly encouraging.
It was a sign of the improving times. Vehicle production is suddenly rising around the world and parts makers are being asked to ramp up output of components to meet the increasing demand. While no one is declaring that global sales will quickly return to 2007 levels, a startling number of rosy forecasts were issued last week.
IHS Global Insight has said that it expects U.S. sales in February to be up by 13.3 percent over the same month last year, and U.S. production for the entire year is now forecasted at 7.09 million units, 26.9 percent above the 2009 level. In addition, automakers and suppliers are counting on double-digit sales rises in China and India this year to make up for an expected fall in European car demand.
Honda told its top suppliers that it would increase global production nearly 10 percent to 3.3 million vehicles in the business year starting next month, led by growth in Asia outside of Japan.
Troubled Toyota told its suppliers that it will increase global production plans by 19 percent to 7.57 million vehicles for 2010 as it sees increased demand in Japan and other Asian markets.
In December, Toyota told its suppliers that it planned to build 7.5 million vehicles in the 2010 calendar year. But it has now shifted that projection upward. In Japan, Toyota has increased its production forecast by 40,000 units because of incentive-backed demand for fuel-efficient cars.
In markets outside Japan, Toyota production is expected to be up by 100,000 units. Even in North America, where the production plan is down by 60,000 units this year because of the recall crisis, many expect the schedule to be revised upward because of the success of incentives.
Nissan had told its suppliers that it will build 3.7 million vehicles in the new fiscal year. That represents a 13 percent increase over the previous year and an all-time high.
A scattering of supplier results last week also sounded upbeat. For example, Autoliv, the world's leader producer of airbags and seatbelts, increased its sales and earnings forecast for the January through March period. The company cited robust demand in Asia and North America.
"The main reason for our revised guidance is better than expected sales, primarily in North America and Asia due to higher light vehicle production accompanied by a favorable mix and market share gains," CEO Jan Carlson said.
With European economies now improving, many government trade-in incentive programs are in the process of closing out. That could slow growth, but Autoliv says so far that it had not limited orders from carmakers.
The growth in demand appears to be having an impact on steel prices, which are rising again because of higher raw material prices. AK Steel Corp. recently told notified customers that it would raise sheet steel prices $40 a ton.
Of course, that means tough contract talks this year between suppliers and steel makers. But that's the kind of thing you get when production comes back.


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Q: UIActivity view controller crashing I have an activity controller, which sometimes crashes and I dont understand why. This is my code:
    func screenShotMethod() {
    //Create the UIImage
    let image = view?.snapshot
    //Save it to the camera roll
    UIImageWriteToSavedPhotosAlbum(image, nil, nil, nil)
    self.socialShare(sharingText: "text", sharingImage: image, sharingURL:NSURL(string: "itms-apps://itunes.apple.com/app/bars/XXXXXXXX"))
}

func socialShare(#sharingText: String?, sharingImage: UIImage?, sharingURL: NSURL?) {
    var sharingItems = [AnyObject]()

    if let text = sharingText {
        sharingItems.append(text)
    }
    if let image = sharingImage {
        sharingItems.append(image)
    }
    if let url = sharingURL {
        sharingItems.append(url)
    }

    let activityViewController = UIActivityViewController(activityItems: sharingItems, applicationActivities: nil)
    activityViewController.excludedActivityTypes = [UIActivityTypeCopyToPasteboard,UIActivityTypeAirDrop,UIActivityTypeAddToReadingList,UIActivityTypeAssignToContact,UIActivityTypePostToTencentWeibo,UIActivityTypePostToVimeo,UIActivityTypePrint,UIActivityTypeSaveToCameraRoll,UIActivityTypePostToWeibo]
    var currentViewController:UIViewController=UIApplication.sharedApplication().keyWindow!.rootViewController!
    currentViewController.presentViewController(activityViewController, animated: true, completion: nil)
    shareButton.alpha = 1.0
}

and here is my UIView snapshot extension:
extension UIView {
var snapshot: UIImage {
    UIGraphicsBeginImageContextWithOptions(bounds.size, false, UIScreen.mainScreen().scale)
    drawViewHierarchyInRect(bounds, afterScreenUpdates: true)
    let result = UIGraphicsGetImageFromCurrentImageContext()
    UIGraphicsEndImageContext()
    return result
}
}

and here are the errors I am getting:
Thread : Fatal Exception: NSGenericException
0  CoreFoundation                 0x25a14fef __exceptionPreprocess
1  libobjc.A.dylib                0x33e00c8b objc_exception_throw
2  UIKit                          0x2970ae63 -[UIPopoverPresentationController presentationTransitionWillBegin]
3  UIKit                          0x2934209d __71-[UIPresentationController _initViewHierarchyForPresentationSuperview:]_block_invoke
4  UIKit                          0x29340a17 __56-[UIPresentationController runTransitionForCurrentState]_block_invoke
5  UIKit                          0x290e4a91 _applyBlockToCFArrayCopiedToStack
6  UIKit                          0x2905f38f _afterCACommitHandler
7  CoreFoundation                 0x259dafed __CFRUNLOOP_IS_CALLING_OUT_TO_AN_OBSERVER_CALLBACK_FUNCTION__
8  CoreFoundation                 0x259d86ab __CFRunLoopDoObservers
9  CoreFoundation                 0x259d8ab3 __CFRunLoopRun
10 CoreFoundation                 0x25925201 CFRunLoopRunSpecific
11 CoreFoundation                 0x25925013 CFRunLoopRunInMode
12 GraphicsServices               0x2d101201 GSEventRunModal
13 UIKit                          0x290c9a59 UIApplicationMain
14 A Void                         0x000ba600 main (AppDelegate.swift:19)
15 libdyld.dylib                  0x3438caaf start

and
Thread : Crashed: com.apple.main-thread
0  A Void                         0x0013aa90 function signature specialization <Arg[0] = Owned To Guaranteed and Exploded, Arg[1] = Owned To Guaranteed, Arg[2] = Owned To Guaranteed> of A_Void.GameScene.touchesMoved (A_Void.GameScene)(Swift.Set<ObjectiveC.NSObject>, withEvent : ObjectiveC.UIEvent) -> () (GameScene.swift:2036)
1  A Void                         0x0013a950 function signature specialization <Arg[0] = Owned To Guaranteed and Exploded, Arg[1] = Owned To Guaranteed, Arg[2] = Owned To Guaranteed> of A_Void.GameScene.touchesMoved (A_Void.GameScene)(Swift.Set<ObjectiveC.NSObject>, withEvent : ObjectiveC.UIEvent) -> () (GameScene.swift:2026)
2  A Void                         0x0010b2bc @objc A_Void.GameScene.touchesMoved (A_Void.GameScene)(Swift.Set<ObjectiveC.NSObject>, withEvent : ObjectiveC.UIEvent) -> () (GameScene.swift)
3  SpriteKit                      0x28f0a8af -[SKView touchesMoved:withEvent:] + 710
4  UIKit                          0x2909a46b -[UIWindow _sendTouchesForEvent:] + 350
5  UIKit                          0x29093df1 -[UIWindow sendEvent:] + 544
6  UIKit                          0x29069fe5 -[UIApplication sendEvent:] + 196
7  UIKit                          0x292e08fb _UIApplicationHandleEventFromQueueEvent + 14414
8  UIKit                          0x290689f9 _UIApplicationHandleEventQueue + 1352
9  CoreFoundation                 0x259dafaf __CFRUNLOOP_IS_CALLING_OUT_TO_A_SOURCE0_PERFORM_FUNCTION__ + 14
10 CoreFoundation                 0x259da3bf __CFRunLoopDoSources0 + 218
11 CoreFoundation                 0x259d8a25 __CFRunLoopRun + 772
12 CoreFoundation                 0x25925201 CFRunLoopRunSpecific + 476
13 CoreFoundation                 0x25925013 CFRunLoopRunInMode + 106
14 GraphicsServices               0x2d101201 GSEventRunModal + 136
15 UIKit                          0x290c9a59 UIApplicationMain + 1440
16 A Void                         0x0014d600 main (AppDelegate.swift:19)
17 libdyld.dylib                  0x3438caaf start + 2

The app is a game made with sprite kit, so I am calling this game method inside SKScene. Also, the game game view controller is the one controlling game scene and it is embed navigation view controller, in which I present gamecenter. Anyone nows how to fix this?

redpajama_set_name: RedPajamaStackExchange


text:
Latest > Thomas Pieters wins Portugal Masters
Photography: Getty Images
Thomas Pieters won his fifth European Tour title after a gutsy final round performance at the Portugal Masters, winning by two strokes at Dom Pedro Victoria.
The Belgian started the day in a share of the lead with Matthieu Pavon, but the Frenchman was cruising after the first eleven holes, holding a two-stroke lead as the pair stood on the 12th tee.
Pavon, chasing a maiden European Tour title, found the water twice on the par five, eventually carding a triple-bogey eight, while Pieters birdied for a four-stroke swing, moving to 19 under par.
Pieters recovered from a bogey on the 14th with a birdie on the 17th and then rolled in a par putt on the 18th hole from twenty feet for a two-stroke victory, his first since the 2019 D+D REAL Czech Masters.
"It feels amazing, really… It felt like a long time between victories. But Adam and I worked so hard, felt like I deserve one. It's never easy coming down the stretch," said Pieters.
"I saw one of the Højgaards, I don't know which one it was, was up there again. I knew I needed a birdie on the last two and that putt on the last was fantastic. I really fancied it, perfect speed and it was nice."
The 29-year-old has now secured his place in the season-ending DP World Tour Championship, Dubai, moving up to twenty-ninth on the Rankings from 70th.
Sharing second with Pavon were the Danish pair of Lucas Bjerregaard and Nicolai Højgaard. Højgaard was chasing his second European Tour victory in the space of just six starts, while Bjerregaard shored up his position inside the Top 100 on the Rankings, securing playing privileges for the 2022 Race to Dubai.
TAGS: European Tour, Portugal Masters, Thomas Pieters, Matthieu Pavon, 2021
Thriston Lawrence wins the Joburg Open
Study Reveals the top 20 golf courses on bucket lists
Cam Smith confirmed for PIF Saudi International
TaylorMade introduces the Stealth 2 Fairways Woods
Ko and Korda heading to HSBC Women's World Championship
Grant out front at Belgian Ladies Open
Swede leads by three heading into the final round


Here is another opporunity to win a $60 Amex and a Febreze product package!
How many times do you walk in a home and wonder to yourself what that funky smell is? Lets face it, this happens! its life, and every home goes nose blind to their homes own smells! Here we have a combo of baby, dogs, weird smelling vegan food...well you get the idea. The issue here is that we dont notice these smells!
Yeah they are cute...but they dont always smell great! Lets face it, spit up and wet dog isnt everyone's idea of a "Homey" smell!
Well we had ourselves a #NOSE BLIND TEST! Ill be brutally honest here, I did not think our house had any scent that wasnt squeaky clean and great. I am a cleaning natzi! I will whip out a sponge and a pail with Mr. Clean so fast that your head would spin. I was surprised that people could smell our dogs and baby scents...And I dont mean that sweet freshly bathed baby smell, I mean that less than sweet sippy cup full of sour milk that hides under your sofa type of baby scent! So to REALLY challenge us we added to this mix extra butter microwave popcorn...yeah we are a strong people..or crazy!Either way we had a popcorn filled movie night. We also gave the kids fishsticks....ohh the smell of tarter sauce and fish! It was BAD. Anyhoo we whipped out the Frebreze! After a quick shot of air freshener and a candle was lit BAM...the reign of burnt butter popcorn and fish was demolished! Well I became inspired....I grabbed the fabric spray! OK I went a lil crazy here, I sprayed every room in our house with it! OMG, I LOVE THIS STUFF! Even better, my daughter swung by and commented on how nice the house smelled....the next day! Yeah I am a fan! And thanks to Frebreze you will be too! One of you gets a chance to win a prize pack of Frebreze and a $60 Gift Card!!
I agree with the comment Julie made. I LOVE Febreeze Air Effects ... the Sweet Pea Petals is amazing! Thank you for the awesome giveaway!
My favorite scent is Rain!
Always love Hawaiin Aloha smells so good!


text:
Transmosis's Small Business Cybersecurity Service with $500,000 in Liability Coverage Expands Globally
Industry leader inks multiple partnerships overseas under new brand, transmosisONE
Jul 08, 2021, 08:58 ET
PHOENIX, July 8, 2021 /PRNewswire/ — U.S. cybersecurity workforce developer, Transmosis, today announced $500,000 of expanded cyber liability coverage and international growth of its enterprise grade cybersecurity-as-a-service, transmosisONE. Designed for the highly vulnerable small business sector and remote work environment, transmosisONE (formerly CyberOPS) will now be available to extensive partner networks in Australia, New Zealand, Canada, and South America through strategic distributors.
Regarded by experts as the most complete, fully outsourced small business and work-from-home cybersecurity solution on the market today, transmosisONE provides critical protection and cyber liability coverage all included in one flexible monthly subscription. Deployed in minutes, the ground-breaking service eliminates complicated setup and lengthy approval processes, enabling small businesses to access the world's top-rated cybersecurity technology without having to sign six-figure multiyear contracts.
transmosisONE's military grade cybersecurity platform combines an Artificial Intelligence powered Extended Detection and Response platform (XDR) with a 24/7 live virtual Security Operations Center (vSOC) utilizing U.S. based security analysts to monitor and proactively eliminate cyber attacks from vulnerable customer endpoints. Its next generation technology is fully integrated with $500,000 of cyber liability coverage, the only small business cybersecurity-as-a-service that ensures full compliance and rapid reimbursements.
"We are excited to offer our unique service to international networks, helping to fill this critical need with sophisticated cybersecurity typically reserved for corporations with very large budgets," said Chase Norlin, Transmosis CEO.
For more information about transmosisONE visit www.transmosis.com/transmosisONE.
About Transmosis
Transmosis is a nationally recognized cyber security workforce developer founded in Silicon Valley that enables American workers to develop new careers in the rapidly growing information security industry. Transmosis's proprietary virtual cybersecurity security analyst training model serves as the foundation of transmosisONE, a Fortune 5000 cybersecurity platform designed to protect small businesses from cyber attack (http://www.transmosis.com/transmosisONE).
Transmosis Media Relations
press@transmosis.com


Home Security Articles Are you Prepared for Incident Response? Are you Prepared for Incident Response?
Every corporate is a victim of direct or indirect information security threat that happens around them it may be a corporate espionage, financial fraud, insider threat, ipr issues and many more for any of these threats the end target is your digital data. Protecting them most advanced techniques like encryption and all will protect the data but is that data stored and can it be retrieved whenever required safely by experts. Now-a-days most of the corporates is undergoing in investigating the threat happened, but the time and cost that they keep in investigation is more. To help to complete investigation more effectively in reduced time with reduced cost Forensic Readiness Assessment can be implemented.
Forensic readiness assessment defines the ability of an organisation to maximise its potential to use digital evidence whilst minimising the costs of investigation. Digital evidence helps in dealing with legal defence, ipr issues, financial frauds and insider threat issues which may impact the business risks, many times we are not so sure of the evidence that has to be collected but when we realise the importance of that specific piece of information it may not be available to avoid such situations even E-discovery will help you to maintain the preservation process where it makes your digital evidence available from the time of legal hold.
Forensic Readiness assessment is done in a systematic, formalised and legal manner to ensure the integrity of the evidence preserved. A forensic investigation for a digital evidence is done as a post incident process most of the times where the integrity of evidence is questionable because of the preservation process done by the IT team. To avoid those kind of issues a processed approach is to be followed which enhances the support for forensic team below (fig 1.1) is the example for a processed approach.
A typical approach for an incident response is mentioned above but identifying the potential evidence for the incidents is a key responsibility below is the list of potential areas where we can search for the traces of digital evidences based on the incident.
Any evidence without proper information is invaluable, so for every evidence before considering it's important to verify the below factors and also these are the factors considered for your investigation time.
When we consider the above factors the major concern is how preservation takes place. It is important to maintain a chain of custody form. Most of the times when preservation is considered it wouldn't be a standard instructions as the evidence may vary. As a part of incident response the major part of evidence would be Logs of network communication, and event logs from the identified machine however it differs from case to case.
While dealing with corporate networks the major challenge is to get the proper logs from the sources as the staff configuring the communication logs at the endpoints may not be aware of certain features or high level crimes that's happening. Considering the type of evidence for the incident like logs from access control systems and testing environment or Honeypots.
The need of Forensic Readiness assessment is more for the corporates for whom insider theft, financial frauds and information security attacks is more. For these organizations digital evidence would be very evidentiary and useful. Before approaching Forensic readiness assessment it is good to have a thorough risk assessment. When considering digital evidence like server data and end-user data for financial or corporate frauds it is a good practise to follow ESI map for more details refer the ISO draft 27050. Fig1.2 refers different best practices before having Forensics readiness assessment to be done.
While conducting incident response activity the major areas that any analyst looks is for Logs and the major fields considered are like source ip, destination ip, hostname, date with time stamp , url info and for some of the log monitoring tools capture the packets transferred in the network however it is a challenge to maintain such information but any trace which can be captured like how much data has been transferred will help the analyst to notice the packet size represents the log format.
As a part of incident response the collection of data is another important source of data from which the root cause of the incident can be identified however it depends from case to case but preserving the state of evidence is always important and ensuring the secure method to collect the information to protect the integrity of the evidence.
Conclusion - Any tool in the market is not perfect, until it is configured properly with proper settings and rules, similarly any network without proper ESI Map or incident handling capabilities is not perfect because of the incidents happening around us. Forensic readiness assessment gives the ability to the organization to use digital evidence when required, and it can minimise the cost and time of an investigation. Forensic readiness assessment is an appropriate process where digital evidence is involved and a risk assessment is done it can be a part of an organization information security policy.
How to Conduct Forensic Analysis of MAC System?
Why E-Discovery is important to Organizations?
How to Perform Basic Static Malware Analysis Using Open Source Tools ?


VelaShape III is FDA approved for circumference reduction of the abdomen and thighs, as well as temporary reduction of cellulite and skin tightening. It allows for body contouring, circumference reduction, cellulite improvement, and skin tightening. While VelaShape does lead to some fat reduction, it is more optimal for reduction in cellulite and skin tightening. It is also a great treatment for patients that have skin laxity after a major weight reduction or pregnancy. Larger treatment areas and fat reduction are better targeted with UltraShape.
VelaShape utilizes infrared and radio frequency energy, in combination with a mild vacuum, to precisely and effectively treat targeted areas of concern. The combination of IR and RF technologies leads to deep heating of fat cells, the surrounding connective tissue, and the underlying collagen. This leads to an increase in circulation, lymphatic drainage, cellular metabolism, and collagen deposition. The result is reduction in skin laxity, and improvement in skin structure and texture.


text:
Fellowships & Training Programs ›
We will begin reviewing applications for the 2020-2021 academic year beginning July 15, 2020 and our interview period will run September-October 2020.
The Fellowship Training Program Hematology, Medical Oncology and Transplantation is directed by Yvonne Datta, MD, Professor of Medicine. The major goal of the Fellowship Training Program is to train physicians for independent and productive academic or clinical careers. Leading to dual-board eligibility in hematology and medical oncology, the three-year program emphasizes clinical training in all areas of hematology, oncology, and transplantation, along with developing the skills needed for a successful academic career in basic or clinical/population outcomes research. The training program is flexible and customized according to the needs and interests of the individual fellow.
Basic and Clinical Research
Clinical training is obtained on in-patient and out-patient hematology and medical oncology services and the blood and marrow transplant service at the University of Minnesota-Fairview Medical Center and the hematology and medical oncology consult and ambulatory services at affiliated hospitals which include the Veterans Administration Medical Center (VAMC), Regions Hospital, and Hennepin County Medical Center (HCMC). Clinical training is also obtained in continuity out-patient clinics at all training sites.
Basic and clinical research in the Division of Hematology, Oncology, and Transplantation provides diverse opportunities for experience in investigational treatment, protocol development and analysis, as well as the performance of sophisticated laboratory techniques. There is also an opportunity for eligible fellows to obtain a masters degree in Clinical Research through the School of Public Health.
The Fellowship Training Program accepts applications only through the Electronic Residency Application Service (ERAS) and offers positions through the National Resident Matching Program (NRMP). Once your completed application has been reviewed, we will contact you regarding its status and the possibility of a visit to our institution for interviews with the program's faculty.
We will begin accepting applications for the 2020-2021 academic year beginning July 15, 2020 and our interview period will run September-October 2020.
IMPORTANT DATES STEPS IN APPLICATION PROCESS
July 6, 2021 Applications can begin being submitted electronically
August 15, 2021 Deadline for receipt of completed application
Sept.- Oct. 2021 Interviews conducted, applications evaluated
November 15, 2020 Rank order list certification deadline
December 2021 Match results released
July 1, 2022 Start of fellowship
Visa Sponsorship: The J-1 alien physician visa sponsored by ECFMG is the preferred visa status for foreign national trainees in all UMN graduate medical education programs; therefore, the Hematology and Medical Oncology Fellowship sponsors only J-1 visas. We do not sponsor H-1B visas. More information can be found on the J-1 visas.
Visit ERAS to submit a fellowship application. The ERAS application must include the following items.
Personal statement that includes your background, education and experience, long-term goals, and areas of interest
Three letters of recommendation (one of which should be from the director of your residency program)
Medical school transcript
USMLE Board Scores
ECFMG Certificate for foreign medical graduates
Send the following documents directly to Mo Laschen at the address listed below.
Notarized copies of current visa status (required for interview, not initial application)
Any documents not accepted by ERAS (i.e., FLEX scores)
Mini-CEX
360-Degree Evaluation
Summary of Evaluation Requirements
Competency Evaluations
Chemo Instill into CF via LP & IV Resevoir
Bone Marrow Biopsy
Patient Evaluations
Generic Evaluation Form
Learning Objectives Form
Days Away Form
Employee Expense Worksheet
Moonlighting Request Form
Fellowship Program Description
Hematology & Medical Oncology Fellowship Program Manual
Dr. Jeremy Allred
Dr. Jeremy Allred completed his MD with Honors in Research from the Medical College of Wisconsin. During residency, Dr. Allred was awarded a Howard Hughes Medical Institute research fellowship exploring transcriptional regulation of hematopoietic stem cells and malignant transformation. He completed Internal Medicine residency as a part of the Physician Scientist Training Program at the University of Minnesota and will be pursuing a career in as an academic physician-scientist with a focus on novel immunotherapies for hematologic malignancies. Dr. Allred joined the University of Minnesota Hematology, Oncology and Transplantation fellowship program in July, 2017.
Dr. Se young Han
Dr. Se young Han received his MD from Kyunghee University College of Medicine, South Korea in 2002. He did his internal medicine residency at Presence Saint Francis Hospital, Evanston, Illinois in 2010. He worked as an assistant professor at Southern Illinois University for 3 years, then continued his career as a BMT hospitalist at Washington University in St. Louis for 4 years. During this period, he was involved in multiple clinical research projects, mainly in hematologic malignancies and their transplant outcomes. His interests are lymphomas, acute leukemia, and immunotherapies in various hematologic malignancies. Dr. Han joined the Hematology, Oncology and Transplantation fellowship program at the University of Minnesota in July 2017.
Dr. Annie M. Jacobsen
Dr. Annie M. Jacobsen received her MD from the University of Minnesota where she was elected to the Gold Humanism Honor Society. She completed her residency at Hennepin County Medical Center, followed by a year as a Chief Resident. In 2018, she was recognized by medical students for superior teaching skills, winning the Distinguished Teaching Award, Resident Instructor from the University of Minnesota. Her research interests include myelodysplastic syndromes and chronic lymphocytic leukemia. Outside of work, she enjoys spending time with her husband and two daughters, doing Kundalini yoga, cooking, and writing. Dr. Jacobsen joined the Hematology, Oncology and Transplantation fellowship program in July 2018.
Dr. Bhaskar Kolla
Dr. Bhaskar Kolla completed medical school training from Guntur Medical College, India and received MBBS with multiple honors including the best outgoing student of his batch. He later did internship and residency training in Internal Medicine at St Francis Hospital, Evanston, during which he received best in-training and best educator awards. Then he worked as a Hospitalist in Mayo Clinic Health System, Eau Claire for 3 years before moving to the University of Minnesota as an Assistant Professor and Hospitalist in the Hematology, Oncology and Bone Marrow Transplantation Division. During this time, he was engaged in clinical research in various topics including cardio-oncology, small cell lung cancer genomics and response to novel therapies, analyzing the role of autotransplant in mantle cell lymphoma in the era of biologic therapies, and studying the impact of adjuvant chemotherapy in appendiceal cancer. The results were presented at major international meetings including ASCO, ASH and ESMO. He joined Hematology & Oncology Fellowship at the University of Minnesota in 2018.
Dr. Amit Kulkarni
Dr. Amit Kulkarni received his MD from Jawaharlal Nehru Medical College, Belgaum, India in 2009. He completed his Internal Medicine residency at Greater Baltimore Medical Center, Baltimore, Maryland. Prior to residency, Dr. Kulkarni was a research fellow at Mayo Clinic, Rochester where he worked on genetics of Chemotherapy-induced Peripheral Neuropathy and genomics of small intestinal neuroendocrine tumors. Dr. Kulkarni joined the University of Minnesota Hematology, Oncology and Transplantation in July, 2017.
Dr. Aimee Merino
Dr. Aimee Merino completed her MD and PhD in the MSTP at the University of Alabama Birmingham. Her thesis work was in natural killer cell receptors and their HLA ligands in HIV-1 infection and transmission. She has done both epidemiologic and bench research in infectious disease and immunology. She completed her internal medicine residency in the Physician Scientist Training Program at the University of Minnesota. During residency, she piloted a project using a video decision tool to aid hospitalized patients in understanding and choosing their code status. Her ongoing research interest is in adoptive transfer of natural killer cells to treat malignancy. Outside of work, her interests include spending time with her two children, riding horses, and advocating for environmental stewardship.
Dr. Grigori Okoev
Dr. Okoev received his MD in 2002 and earned his Ph.D. degree in 2009 from Yerevan State Medical University, Armenia. He completed an Internal Medicine residency at MedStar Health (Harbor Hospital), Baltimore, Maryland. Before starting residency, Dr. Okoev was a research fellow at Georgia Cancer Center, Augusta where he worked on the development of combinational cancer immunotherapies and investigation of the evaluation of tumor-mediated immune suppression. After fellowship, Dr. Okoev plans to continue his focus on hematologic malignancies. Outside the work, he enjoys spending time with his family.
Dr. Sean I. Tracy
Dr. Sean Tracy received his MD/PhD from Tufts University, where his dissertation focused on interactions between the Epstein-Barr Virus (EBV) and host B-cells. Following this, he completed his residency in Internal Medicine at the Mayo Clinic in Rochester, MN. During residency, he was involved in several research projects focused on survival outcomes among patients with lymphoma. His interests are in malignant hematology and bone marrow transplantation. Dr. Tracy joined the Hematology, Oncology and Transplantation Fellowship program in July 2017.
Dr. Haiyun Wang
Dr. Haiyun Wang earned her medical degree with honors at Zhejiang Medical University in China. She received her MPH degree at Johns Hopkins University Bloomberg School of Public Health. She completed her residency training at Geisinger Medical Center in Danville, Pennsylvania. She then continued her career as a hospitalist at Geisinger for 7 years. During that period, she conducted researches on breast cancer chemoprevention. Dr. Wang is interested in precision medicine in breast cancer treatment and prevention. She joined the Hematology, Oncology and Transplantation Fellowship program in July 2018.
Dr. Allison Watson
Dr. Allison Watson completed her MD and PhD at the University of South Dakota Sanford School of Medicine, where her research focused on identification and characterization of diagnostic and prognostic markers in breast cancer. She completed her residency in Internal Medicine at the University of Minnesota, and then spent a year as a hospitalist for the inpatient hematology, oncology and bone marrow transplant teams at the University of Minnesota. She joined the Hematology, Oncology and Transplantation Fellowship program at the University of Minnesota in July 2018.
Dr. Winston Woan
Dr. Karrune (Winston) Woan completed the MD/PhD program at the University of Florida in 2014. He completed his thesis work at Moffitt Cancer Center where he studied the role of HDACs in tumor and T-cell immunobiology in the context of immune tolerance under the mentorship of Dr. Eduardo Sotomayor. He was then accepted into the Physician-Scientist Training Pathway at the University of Minnesota in 2014. Dr. Woan has research interests in basic and translational tumor immunology. He joined the Hematology, Oncology and Transplantation fellowship program at the University of Minnesota in July 2016.
Dr. Shijia Zhang
Dr. Shijia Zhang received his MD from Tongji University School of Medicine, China. He earned his PhD in Biomedical Sciences from Tulane University School of Medicine, where he studied the immunomodulatory properties of bone marrow- and adipose-derived mesenchymal stem cells. Dr. Zhang completed his residency training in Internal Medicine at Rutgers New Jersey Medical School. During residency, he presented posters at both ASH and ASCO. Dr. Zhang joined the Hematology, Oncology and Transplantation fellowship program in July 2017.
Dr. Nicholas Zorko
Dr. Nicholas Zorko is a native of Canton, Ohio. He graduated from the Ohio State University in 2015 with his MD and PhD degrees. His PhD project focused on developing clinically-relevant models of AML for mechanistic and therapeutic studies. He completed residency in Internal Medicine at the University of Minnesota as a member of the Physician Scientist Training Program. He plans to continue studying hematologic malignancies with a focus on novel therapeutic development. He is also interested in optimizing the use of electronic medical records in research and clinical practice and is a certified Epic Physician Builder. Outside of the hospital he enjoys cycling, cross country skiing, and growing heirloom tomatoes. He joined the Hematology, Oncology and Transplantation Fellowship program in July 2018.
Dr. Yvonne Datta
Mo Laschen
lasc0020@umn.edu