Alcoholic fatty liver disease (AFLD) is a significant public health concern. Excessive alcohol (ethanol) consumption causes liver cell damage and death, which results in eventual failure of the liver and death. AFLD is the number one cause of liver-related mortality in the United States. Our lab works with the novel protein C1q TNF Related Protein 3 (CTRP3), which inhibits non-alcoholic fatty liver disease, however the effects on AFLD are unknown. Therefore, the purpose of this experiment is to determine if CTRP3 prevents ethanol-induced liver cell death. The H4IIE rat hepatoma cell line was chosen for experimentation as a cell culture model of liver tissue. To determine a suitable alcohol level H4IIE cells were treated with 50, 100, and 200 mmol of ethanol for 18-24 hours. Trypan Blue was used to identify the dead/damaged cells, as only dead/damaged cells will be stained blue with this protocol. We observed that 100 mmol of ethanol consistently induced ~10% mortality rate in these cells. Next, we tested the ability of CTRP3 to reduce ethanol-induced mortality. We added purified CTRP3 protein to the cell media along with the 100 mmol ethanol treatment. The addition of CTRP3 reduced the amount of alcohol-induced cell death/damage in the H4IIE cell line by approximately 60%. Our next goal was to determine how CTRP3 reduces ethanol-induced death. The Akt signaling pathway is a well-known inhibitor of cell death. Therefore, to determine if CTRP3 attenuated ethanol-induced cell damage/death through activation of the Akt signaling pathway, another set of cells was treated with 100 mmol of ethanol and CTRP3 (with or without insulin). Western blots were used to compare the amount of active Akt (phosphorylated) in the CTRP3-treated and non-treated cells. A Western blot utilizes an electric current to separate denatured protein samples on a SDS-page gel, separating the proteins based on size. The smaller the protein the faster it migrates across the gel. The proteins are then transferred to a membrane for analysis, through exposure to commercial antigens and chemiluminescence imaging. There was no change in the amount of total or active Akt between the samples treated with or without CTRP3. We conclude that CTRP3 protects liver cells from ethanol-induced damage/death, but not through activation of the Akt pathway.


Donald Trump has had the mic long enough. And the Main Stream Media made him lead the discourse. It's time for the Independent Progressive media to take over – talk new economy.
Do you remember there were days during both the Obama and Bush administration when the name of the President went virtually unuttered? Even as the media has always been derelict in its duty with issues that matter most to most Americans, there was at least some oxygen left to get issues that mattered out.
Donald Trump is all consuming. And in the two years he has played president nothing of substance other than the theft, the wealth transfer to the least deserving, the billionaires that pilfer us most.
We will talk about real issues today. I will touch on what I think the economy should look like.
Border Radio, Best of Americana music featuring Susan Darrow right after Politics Done Right at 4:00 PM.
Support Politics Done Right: Become a Patron now.


text:
SFSFF Celebrates 15 Years of Kicking Ass (Silently—gotta include a 'silent' joke)
The 15th Annual San Francisco Silent Film Festival opens tonight, and I wouldn't want to be anywhere else in the world. There are plenty of great film festivals film that provide the rush of new discoveries, and there are other archival festivals that show rarer films than those on display this weekend. But there's something simply magical about watching a pristine print on the giant screen of the Castro Theatre, the city's gorgeous 1922 movie palace, with great live music (orchestral, organ, piano, etc.). The festival has left me with many great memories—the emotional rush of "The Man Who Laughs," Stephen Horne's gut-wrenching, draining score to "Jujiro," The sustained laugher of "Steamboat Bill, Jr.," accompanied by The Alloy Orchestra.
I first attended the festival in 2000, when it was a one-day event. And while I haven't made it every year since, I've happily monitored its growth, which has been remarkable. It's nearly quadrupled in duration, opening on a Thursday night and running through Sunday. There's a mini WInter festival now, too.
Both Horne and Alloy will be back this year. The Alloy Orchestra will debut the extended version of its "Metropolis" score (the band's first, although when they formed the movie was an hour shorter) to fit the newly restored version of Fritz Lang's masterpiece. Sadly "Metropolis" is the only film being projected digitally—thanks Kino. Alloy will perform its legendary accompaniment to Dziga Vertov's playful experimental classic "Man With a Movie Camera." Horne will take on "Rotaie," an expressionistic Italian film that will surely play to his strengths, as well as Frank Capra's "The Strong Man," starring Harry Langdon.
"The Strong Man" will also feature a tribute to Kevin Brownlow, a great writer, preservationist, documentarian and all-around advocate of cinema. Any award you can think to give him, he deserves.
Check out this preview by Brian Darr, the king of San Francisco movie-going. (His Twitter feed alone fills me with envy over San Francisco's reportory film scene. I ought to move!)
Posted by Jeremy Mathews at 4:29 PM
Labels: San Francisco Silent Film Festival, SFSFF, Silent FIlm, Stephen Horne
SFSFF 2010: A Festival There Was
SFSFF 2010: Diary of a Silent Film Junkie
SFSFF Celebrates 15 Years of Kicking Ass (Silently...
SDP 27: Aged Like a Fine Wine

redpajama_set_name: RedPajamaCommonCrawl


text:
KS Pogradec est un club albanais de football basé à Pogradec.

Historique du club
 1932 - fondation du club
 1936 -  en Super League

Pogradeci
Club de football fondé en 1930

redpajama_set_name: RedPajamaWikipedia


text:
Unintended Consequences of mHealth Interactive Voice Messages Promoting Contraceptive Use After Menstrual Regulation in Bangladesh: Intimate Partner Violence Results From a Randomized Controlled Trial
Kate Reiss, Kathryn Andersen, Erin Pearson, Kamal Biswas, Fahmida Taleb, Thoai D. Ngo, Altaf Hossain, Sharmani Barnard, Chris Smith, James Carpenter, Jamie Menzel, Katharine Footman, Katherine Keenan, Megan Douthwaite, Yasmin Reena, Hassan Rushekh Mahmood, Tanzila Tabbassum, Manuela Colombini, Loraine Bacchus and Kathryn Church
Global Health: Science and Practice September 2019, 7(3):386-403; https://doi.org/10.9745/GHSP-D-19-00015
Kate Reiss
Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.
For correspondence: kate.reiss@lshtm.ac.uk
Kathryn Andersen
Ipas, Chapel Hill, NC, USA.
Erin Pearson
Kamal Biswas
Ipas Bangladesh, Dhaka, Bangladesh.
Fahmida Taleb
Marie Stopes Bangladesh, Dhaka, Bangladesh.
Thoai D. Ngo
Population Council, New York, NY, USA.
Altaf Hossain
Association for Prevention of Septic Abortion, Bangladesh, Dhaka, Bangladesh.
Sharmani Barnard
School of Population Health and Environmental Sciences, King's College, London, UK.
School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
James Carpenter
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
Jamie Menzel
Katharine Footman
Marie Stopes International, London, UK.
Katherine Keenan
School of Geography and Sustainable Development, University of St. Andrews, St. Andrews, UK.
Megan Douthwaite
Yasmin Reena
Hassan Rushekh Mahmood
icddr,b, Dhaka, Bangladesh.
Tanzila Tabbassum
Manuela Colombini
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Loraine Bacchus
Kathryn Church
Automated interactive voice messages about post-menstrual regulation contraception delivered to women in Bangladesh via mobile phone were associated with increased reports of intimate partner violence. This finding highlights the importance of taking steps to minimize risk when delivering phone messages on sensitive topics and the need for assessing violence in such situations.
Background: Mobile phones for health (mHealth) hold promise for delivering behavioral interventions. We evaluated the effect of automated interactive voice messages promoting contraceptive use with a focus on long-acting reversible contraceptives (LARCs) among women in Bangladesh who had undergone menstrual regulation (MR), a procedure to "regulate the menstrual cycle when menstruation is absent for a short duration."
Methods: We recruited MR clients from 41 public- and private-sector clinics immediately after MR. Eligibility criteria included having a personal mobile phone and consenting to receive messages about family planning by phone. We randomized participants remotely to an intervention group that received at least 11 voice messages about contraception over 4 months or to a control group (no messages). The primary outcome was LARC use at 4 months. Adverse events measured included experience of intimate partner violence (IPV). Researchers recruiting participants and 1 analyst were blinded to allocation groups. All analyses were intention to treat. The trial is registered with ClinicalTrials.gov (NCT02579785).
Results: Between December 2015 and March 2016, 485 women were allocated to the intervention group and 484 to the control group. We completed follow-up on 389 intervention and 383 control participants. Forty-eight (12%) participants in the intervention group and 59 (15%) in the control group reported using a LARC method at 4 months (adjusted odds ratio [aOR] using multiple imputation=0.95; 95% confidence interval [CI]=0.49 to 1.83; P=.22). Reported physical IPV was higher in the intervention group: 42 (11%) intervention versus 25 (7%) control (aOR=1.97; 95% CI=1.12 to 3.46; P=.03) when measured using a closed question naming acts of violence. No violence was reported in response to an open question about effects of being in the study.
Conclusions: The intervention did not increase LARC use but had an unintended consequence of increasing self-reported IPV. Researchers and health program designers should consider possible negative impacts when designing and evaluating mHealth and other reproductive health interventions. IPV must be measured using closed questions naming acts of violence.
Bangladesh has seen a rapid increase in use of contraception over the last 40 years; however, among married women in Bangladesh, 12% wanted to delay or stop childbearing but were not using a method in 2014.1 Furthermore, 48% of all pregnancies in Bangladesh are estimated to be unintended, leading to health, social, and economic costs for women and their families.2,3 The type of contraceptives women use has implications for unintended pregnancies: long-acting reversible contraceptives (LARCs)—intrauterine devices (IUDs) and implants—are the most effective reversible methods, with failure rates of between 0.1% and 0.8% in the first year of typical use.4 In contrast, short-acting methods have higher typical-use failure rates of 4% (the injectable), 7% (the pill), and 13% (male condoms).4 LARCs also have low levels of discontinuation and high user satisfaction.5,6 In Bangladesh, 62% of married women of reproductive age use contraception, but just 2% use a LARC and 30% of contraceptive users discontinue their method within a year.1 Although awareness of contraceptive methods in Bangladesh is high,7 many women lack accurate information on method attributes, particularly for long-acting methods, and fear of negative effects is common.7 Increased information provision about LARCs has been shown to increase uptake of these methods.8
Women terminating a pregnancy are a key group to reach with information about contraception as they usually want to delay or prevent future pregnancies. Legally, abortion is available in Bangladesh only to save a woman's life,3 but menstrual regulation (MR), "the procedure of regulating the menstrual cycle when menstruation is absent for a short duration,"9 is authorized in public and government-approved NGO and private health facilities up to 12 weeks since the last menstrual period.10 In 2014, an estimated 430,000 MR procedures took place in health facilities in Bangladesh.3 Family planning services are offered following MR procedures, but service quality and the range of available methods vary.11 Furthermore, some women report not wanting to make a decision about contraception on the day of their procedure.12
Mobile phones have the potential for rapidly delivering targeted communications to large and disparate populations at low cost. Evidence shows that mobile phones for health (mHealth) can be effective at changing behavior and improving health outcomes,13 and they are increasingly being used by sexual and reproductive health programs to support clients. In recent years, mHealth interventions have been used to promote safer sex and partner notification of sexually transmitted infections,14,15 increase contraceptive use,16 support antiretroviral adherence and clinic attendance among people living with HIV,17,18 reduce HIV transmission risk among male sex workers,19 support women through the home phase of medical abortion,20 and provide support for pregnant women and new mothers.21,22 Some of these intervention types are still at the feasibility or pilot stages, but others have been scaled up. One of the scaled-up interventions is the Mobile Alliance for Maternal Action (MAMA) approach, which started in 2010 and uses a range of mobile technologies (including text messages, voice calls, and apps) to support maternal and newborn health. By 2016, it had 1.9 million subscribers in Bangladesh, 600,000 in India, and 500,000 in South Africa.22
Moderate-quality evidence indicates that text messages are effective in supporting antiretroviral adherence and clinic attendance for HIV and sexually transmitted infections.18,23 In many other areas of mHealth for sexual and reproductive health, however, the evidence is limited, and mixed and more rigorous trials are needed.16,18,24 With respect to contraception, text message interventions in the United States have successfully increased pill continuation and attendance for injectable appointments, interactive voice messages with counselor phone calls have increased use of LARCs among abortion clients in Cambodia, and phone-based information sessions have increased effective contraceptive use among postpartum clients in Ecuador; however, other interventions have had no effect on contraceptive outcomes or have improved knowledge but failed to change behavior.16,25,26 Feasibility research exploring the use of text message contraceptive reminders among MR and postabortion care (PAC) clients in Bangladesh had promising results, although some concerns were raised about unintended recipients seeing text messages.27
Some evidence shows that communication about sexual and reproductive health and access to services can precipitate intimate partner violence (IPV) toward women in certain relationships.28,29 Furthermore, some studies suggest that women's empowerment (e.g., through increased earnings) can more broadly result in increased IPV as new roles are negotiated, but the findings on this topic are mixed.30 With respect to phone interventions, a systematic review published in 2013 investigated the effect of mHealth on gender relations and highlighted cases of resulting domestic dispute; however, the authors reported that data were very limited, noting their suspicion that this outcome is not routinely being measured.31
Communication about sexual and reproductive health and access to services can precipitate IPV toward women in certain relationships.
More broadly, evaluations of public health interventions often fail to assess potential harms and their underlying mechanisms.32 Randomized controlled trials (RCTs) evaluating mHealth family planning interventions have not reported any adverse effects; however, few trials report measuring negative outcomes.8,25,33–41 Recent systematic reviews of family planning interventions suggest that impacts on partner relations (including violence) are not routinely measured in this field.16,42 Monitoring adverse events, and specifically IPV, remains important when evaluating mHealth interventions for reproductive health.
Given the success of the Cambodian intervention and largely positive findings of the feasibility study in Bangladesh, 2 NGOs designed an enhanced mHealth intervention to support post-MR contraceptive use in Bangladesh, with a focus on overcoming barriers to LARC use. The initiative was a partnership between Marie Stopes Bangladesh (MSB), which operates private reproductive health clinics (140 at the time of implementation), and Ipas Bangladesh, which supports government facilities and clinics within the nongovernmental Reproductive Health Services Training and Education Program (RHSTEP) in provision of MR, PAC, and family planning through provider training. The intervention comprised automated interactive voice messages sent to women's mobile phones in the 4 months after MR. The Cambodia intervention relied heavily on call center counseling, and the cost of this component has been cited as a possible barrier to scale-up.43 We explored whether an intervention containing more detailed automated content about contraception could be effective. We hypothesized that women who receive a multicomponent mHealth intervention will have a higher rate of LARC use at 2 weeks, 4 months, and 12 months after MR, compared with women who do not receive the mHealth intervention. We also hypothesized that the intervention would increase use of any modern method, reduce subsequent pregnancy or MR, and reduce discontinuation among existing users. The conceptual framework (Figure 1) drew on the COM-B model of behavior change.44 The aim of this study was to evaluate the effect of the intervention on contraceptive use and to monitor for adverse events, including IPV, which is widespread in Bangladesh; in 2015, 50% of ever-married women reported having experienced physical violence and 27% sexual violence by their current or previous husband.45
Conceptual Framework for the Mobile Phone Intervention Designed to Support Post-Menstrual Regulation Contraceptive Use in Bangladesh
Abbreviations: LARC, long-acting reversible contraceptive; MR, menstrual regulation.
This study evaluated the effect of the mHealth intervention on contraceptive use and monitored for adverse events, including IPV.
This study was a single-blinded, multisite RCT of an interactive voice message intervention delivered via mobile phone designed to support post-MR contraceptive use. Women were recruited from 41 health facilities sampled from 93 eligible clinics: clinics located in Chittagong, Dhaka, or Sylhet division (chosen for having lower modern contraceptive prevalence than other divisions at 47%, 54%, and 41%, respectively),1 were an MSB facility or a government facility supported by Ipas Bangladesh, had a minimum monthly MR case load of 20, and had no other intervention study underway at the start of recruitment. Facilities were stratified according to size: primary clinics were located in rural and peri-urban areas; secondary clinics, located in urban areas, were larger and provided a wider range of services; and tertiary facilities were hospitals located in large cities. Seventeen units of 19 women were sampled from each strata (N=969 women), using probability proportional to MR client load with some higher-volume facilities being sampled multiple times. During recruitment some clinics had lower client flow than expected and an additional 4 units were sampled to enable the sample size to be reached during the recruitment period. Twenty-five of the sampled clinics were MSB and 16 were government and nongovernment RHSTEP facilities supported by Ipas Bangladesh. Thirteen sampled clinics were in Chittagong, 23 in Dhaka, and 5 in Sylhet. The trial protocol was published in 2017.46 Ethical approval was received from the Bangladesh Medical Research Council, the London School of Hygiene and Tropical Medicine Research Ethics Committee, the Marie Stopes International Ethical Review Committee, and the Population Council Institutional Review Board.
Women were eligible to participate if they had had an MR procedure from a participating clinic during the recruitment period, were 18 to 49 years of age, did not receive general anesthesia for their MR procedure (since recruitment took place immediately after the MR procedure at which time general anesthetic clients may not have been well enough to give informed consent), were physically and emotionally able to consent, reported that they had a personal mobile phone, consented to receive voice messages about family planning on their phone, and did not intend to become pregnant or use a permanent method of contraception in the next 6 months. The latter group were excluded as the intervention focused on supporting uptake and continuation of and switching between contraceptive methods, which was information not deemed to be relevant to women using permanent methods. The study was introduced to women by the clinic provider after completing MR services. Interested participants were referred to a clinic-based research assistant (RA) for screening and recruitment, which took place within 2 days of the MR. All participants gave written informed consent in the presence of a witness of their choice.
Study recruitment ran between December 19, 2015, and March 1, 2016. We screened 1919 MR clients, 947 refused to take part or were ineligible, and 972 were recruited (Figure 2). We do not have a breakdown of the number according to refusal or ineligibility. We also do not have quantitative data on the reasons for refusal or ineligibility; however, RAs reported that the most common reasons for nonparticipation were refusal due to not having time, concern from the woman that her family would find out about her MR, and lack of approval from the woman's husband. The most common reasons for ineligibility were wanting to conceive within the next 6 months, planning to use sterilization, and having received general anesthesia for the MR procedure.
Flowchart of Participants in a Randomized Controlled Trial of a Mobile Phone Intervention Designed to Support Post–Menstrual Regulation Contraceptive Use in Bangladesh (2015–2016)
Randomization and Masking
Participants were allocated with a 1:1 ratio to the intervention (mobile phone interactive voice messages) or control group (no voice messages). The allocation sequence was generated remotely prior to the start of enrollment and kept by an independent researcher based in Dhaka using the Microsoft Excel formula "=RANDBETWEEN(1, 2)". No minimization was used. Allocation concealment was achieved via the following steps:
Participants were entered into the mHealth platform by recruiting RAs using a secure app following enrollment.
At the end of each day, a list of new participant IDs was downloaded from the system by a technical officer at MSB and sent to the independent researcher, who had no contact with RAs or participants.
The independent researcher assigned the IDs sequentially to the pregenerated allocation list.
The independent researcher sent the ID list with allocations to the technical officer, who activated calls for intervention participants.
RAs recruiting and interviewing participants, clinic staff, and participants were not informed of participant allocations. Participants were told that if they were in the intervention group they would start receiving messages within a few days of recruitment.
A total of 969 participants were randomized correctly, 485 and 484 to the intervention and control groups, respectively. Enrollment paperwork was lost for 5 participants, and 2 participants were excluded at baseline due to age ineligibility.
All participants received existing standard care at the clinic, which included family planning counseling and offer of available methods, and were provided with the number of a paramedic-led reproductive health call center operating 24/7 and established at MSB for the study. Calls to the call center were charged at the price of a call to a mobile phone. Intervention participants were sent automated interactive voice messages to their mobile phone over the 4-month period after their MR; the intervention is summarized in Box 1 and full details are given in Supplement 1. Sample message content is provided in Box 2 and all messages are included in Supplement 2. Control participants were not sent any voice messages. Participants were interviewed in person at baseline and via phone at 2 weeks and 4 months post-MR. Responses were recorded on paper at the time of interview and entered into a Microsoft Access database by a data entry clerk at a later date. RAs conducting follow-up interviews were blinded to allocation at the start of each interview. Participants were reimbursed the following amounts for starting an interview: 300 Bangladeshi taka (BDT) (US$3.84 in December 2015) at recruitment, 100 BDT (US$1.28) at the 2-week follow-up, and 200 BDT (US$2.56) at the 4-month follow up. Participants could withdraw from the study during interviews or at any time by calling the study number or call center.
Summary of the Mobile Phone Intervention
Intervention Development and Aims
The intervention development drew on formative and feasibility research conducted in Bangladesh,16,22 behavior change theory,20 and literature on evidence for mHealth globally and barriers to contraceptive use in this population.14 The aim of the intervention was to address information gaps and misconceptions about contraception, particularly for long-acting reversible contraceptives (LARCs), increase motivation for family planning uptake among nonusers, support continuation among users, and encourage method switching for those unhappy with their method.
Intervention Structure
The intervention comprised 11 interactive voice messages delivered to the participant's mobile phone over the 4 months post-menstrual regulation (MR). The first 7 messages were delivered at weekly intervals and the remainder at fortnightly intervals. Participants were asked at recruitment to select 1 of 5 time slots when they would prefer to receive the messages. When the message was sent, if switched on and in network coverage, the phone would ring. If it was answered, the automated content would start to play. If the message was not delivered or answered it would be resent twice after 30-minute intervals. After 3 failed attempts, no further calls would occur until the next scheduled message. It is uncommon in Bangladesh for mobile phones to have voicemail capacity, so messages were not stored for later access.
Intervention Content
Seven generic messages were sent to all clients, aiming to increase motivation for contraceptive use and address common fears and information gaps, particularly for LARCs, and 4 messages were tailored to the method of contraception (or no method) chosen by the participant after their MR procedure. If use of a different method was reported in the 2-week survey or to the call center, the woman's message group was updated and messages restarted. Consequently, women who switched methods received more than 11 messages over a duration longer than 4 months. Messages included factual information delivered by a "doctor apa" (female doctor), 2 personal stories in which women told of their experience using an implant or IUD, and a message recorded by a local celebrity endorsing LARCs.
Each message ended with a menu allowing participants to use their keypad to repeat the initial content, listen to further content (a factual message about each modern method of contraception available in Bangladesh), connect to the call center to receive personalized counseling, indicate they did not need further information at that time, or opt out from receiving further messages.
Cost and Management of the Intervention
Messages, including connecting calls to the call center, were free to call recipients. The intervention was built and hosted by "I am digital" (Dhaka), and messages were scheduled to be sent out on a daily basis by a technical officer based at MSB in Dhaka. Members of the study team were enrolled into the intervention to monitor its functioning.
For additional details about the intervention, see Supplement 1.
Sample Interactive Voice Message Content
Pill Message 1 (sent to pill users only)
Hello, this is your doctor apa calling to congratulate you for choosing pills! Pills are effective in preventing pregnancy if taken at the same time every day. Remember that to work, pills must be taken every day whether or not you have sex. If you miss a pill, always take one missed pill immediately, then continue with the pills in the pack on your normal schedule. If you miss three or more pills in a row, you are at risk for pregnancy so use condoms for seven days and consider using emergency contraception. If you have questions or concerns about using pills correctly, we are available 24 hours a day to give advice. To listen to the message again, press 1. To learn more about family planning methods, press 2. Press 3 to talk to a counselor. If you don't need any information now, press 4. Press 5 to stop receiving these messages.
Implant Personal Experience Message (sent to all participants)
Hello, my name is Mithila, and I'm calling as part of your doctor apa program to tell you why I chose to use an implant. We have been married for three years, and we knew we wanted to have children, but we didn't want them straight away. I started using the pill, but I was not very good at remembering to take it every day, which made me worry about getting pregnant. I decided to visit a provider at a nearby health center, who told me that the implant would protect me for up to three years and I would be free from the worry of unintended pregnancy. I was nervous about having something placed under the skin of my arm, but the doctor showed me where it would be placed, where it will remain, and how it will protect me from pregnancy. The insertion was quick—it only took about five minutes, and then I didn't have to worry about it anymore. My bleeding got a bit lighter after the first few months. Last year, I decided to have my implant removed, and within three months I was pregnant. Now that our baby is born, I am preparing to get an implant again. If you're interested in more facts about the implant, speak to a service provider or visit the hospital. To listen to the message again, press 1. To learn more about family planning methods, press 2. Press 3 to talk to a counselor. If you don't need any information now, press 4. Press 5 to stop receiving these messages.
For all message content, refer to Supplement 2.
Procedures to Minimize the Risk of Harm
The study was designed with the following procedures to minimize the risk of harm. Many women in Bangladesh report needing to obtain permission from their husband before making decisions.47 At recruitment, women were given the additional options of enrolling with their husband or other individual of their choice, discussing the study with others before enrolling, having the RA call their husband or someone else to explain the study, and enrolling at a location of their choice. During enrollment, women listened to an example of an automated voice message about family planning and were asked if receiving similar messages on their phone was acceptable to them, what would happen if their husband or partner heard the message, and what would happen if someone else such as an in-law or other family member heard the message. If concerns were raised, the participant was advised not to participate. The intervention did not mention MR or abortion, the participant's visit to a clinic, or the source of the messages being MSB or Ipas Bangladesh. At the end of each automated voice message, participants had the option of pressing 5 on their key pad to opt out from getting further messages. They could also opt out of the intervention by calling the call center or study number, both of which they received at recruitment.
The primary outcome was self-reported LARC (IUD or implant) use at 4 months post-MR. Secondary outcome measures were use of a LARC at 2 weeks; use of any effective modern contraceptive method, defined as methods with <10% 12-month pregnancy rate (pill, injectable, implant, IUD, or sterilization), at 2 weeks and 4 months post-MR; and subsequent MR, pregnancy, adverse events including experience of violence, or contraceptive discontinuation at any point during the 4-month intervention period. Contraceptive discontinuation was measured using an adaptation of the Demographic and Health Survey contraceptive calendar.1 At 4 months, participants were also asked about intervention use. Adverse events were measured using an open question: "Did anything happen to you as a result of you being in this study? Good or bad?" Participants who said yes were asked what happened. In addition, violence was measured using 3 closed questions that named specific acts:
Physical IPV: "In the last 4 months since the MR when you joined this study, has your husband/partner hit, kicked, slapped, or otherwise physically hurt you?"
Sexual IPV: "In the last 4 months since the MR when you joined this study, has your husband/partner physically forced you to have sexual intercourse with him even when you did not want to?"
Physical violence perpetrated by the participant's in-laws: "In the last 4 months since the MR when you joined this study, have your in-laws hit, kicked, slapped, or otherwise physically hurt you?"
No data and safety monitoring board was set up for this study because the intervention was behavioral, not clinical, and the negative effects of mHealth were thought to be minimal. The ethics committees that reviewed the study and the STEP-UP Consortium Advisory Group advised on safety aspects when follow-up data were analyzed.
Using data from MSB and government clinics supported by Ipas Bangladesh, we estimated that 9.4% of control participants would be using a LARC after 4 months. Therefore, assuming equal numbers of women in the intervention and control group, we calculated that a minimum of 960 participants would be required to detect an increase in LARC use of 7% in the intervention group to 16.4% at 4 months of follow-up (a relative risk of 1.74), with .05 significance level and 80% power, allowing for 25% loss to follow-up. A similar intervention in Cambodia revealed an increase in LARC use from 9% to 29% after 4 months;8 however, a smaller difference could be important given the low cost of sending phone messages.
We conducted analyses on an intention-to-treat basis using Stata version 14.2 (StataCorp LLC, College Station, TX) and followed the prespecified analysis plan.46 Two independent analyses were conducted, and one analyst [JC] was blinded to the allocation groups. We calculated the effect of the intervention on the primary and secondary outcomes as an odds ratio with a 95% confidence interval using multivariate logistic regression to allow us to adjust for any baseline imbalances among prespecified variables that we hypothesized may be associated with the outcomes: baseline method use (method taken on the day of the MR) or experience of violence in the past year, age, and socioeconomic status (SES) measured using the Poverty Probability Index (PPI).48,49 We used multiple imputation (MI)50 to impute missing outcome and baseline data separately for the 2 allocation groups during analysis of the primary outcome: we used baseline, 2-week, and 4-month LARC use; baseline age; and SES (PPI score) to impute 100 data sets.48 We then fitted the logistic regression of 4-month LARC use on allocation group and baseline LARC use to each imputed data set and combined the results for final inference using Rubin's rules.
As a check on our imputation analysis, we conducted logistic regression of 4-month LARC use on allocation group without multiple imputation, adjusting for age, SES (PPI score), and baseline LARC use. This analysis therefore makes a slightly stronger missing at random assumption than the MI analysis. Where there was some evidence (from a simple association test) for an intervention effect on a secondary outcome, we conducted a model-based analysis using MI (which was not specified in the analysis plan). The MI model included the secondary outcome under consideration; intervention; baseline use/experience of secondary outcome being investigated; baseline, 2-week, and 4-month LARC use; baseline age; and SES (PPI score). Logistic regression of secondary outcome on intervention and baseline was then fitted to each imputed data set, and the results were combined for final inference using Rubin's rules. Because there were imbalances in some baseline data, we carried out additional logistic regression of imputed data sets, adjusting for baseline variables that were prespecified in the protocol or where there was a significant difference between groups: use or experience, age, SES, and education.
We carried out a subgroup analysis to examine any difference in effect of allocation on the primary outcome using logistic regression controlling for age, SES, and baseline use where these were not subgroup categories. Six subgroups were prespecified, and 1 was added during analysis (facility type). We assessed contraceptive discontinuation among participants who started using an effective contraceptive method during the first 4 weeks post-MR, using Kaplan-Meier survival analysis and the log rank test. We defined discontinuation as stopping a method and not starting another effective modern contraceptive method within 2 weeks. We present curves by method for the pill and injectable individually and a combined curve for LARCs due to the low numbers of participants who discontinued these methods. We carried out an additional (not prespecified) subgroup analysis to examine any difference in effect of allocation on physical IPV using logistic regression controlling for age, SES, and baseline experience of physical IPV where they were not subgroup categories.
The trial has been registered with ClinicalTrials.gov (NCT02579785) since October 16, 2015.
Role of the Funding Source
The funder of the study had no role in study design, data collection, data analysis, or data interpretation or in writing of the report. The corresponding author had full access to all study data and had final responsibility for the decision to submit for publication.
We analyzed baseline data for 962 participants (Table 1). Follow-up was completed in July 2016 and primary outcome data were collected and used from 772 participants, an 80% follow-up rate; 389 (80% follow-up rate) from the intervention arm, and 383 (79% follow-up rate) from the control arm.
Baseline Characteristics of the Intention-to-Treat Population
No evidence was found for an effect of the intervention on the primary outcome of LARC use at 4 months post-MR: 48 (12%) of intervention participants and 59 (15%) of control participants reported using a LARC at 4 months (P=.22). After imputing missing data, we found no evidence that participants in the intervention arm had higher odds of using a LARC than women in the control arm (adjusted odds ratio [aOR]=0.95; 95% confidence interval [CI]=0.49 to 1.83). The prespecified analysis under a weaker missing at random assumption also revealed no evidence that odds were higher in the intervention arm (aOR=1.06; 95% CI=0.53 to 2.13). There was also no evidence for an effect of the intervention on use of any effective modern contraception at 4 months, subsequent pregnancy, subsequent MR, or on LARC and any effective modern method use at 2 weeks post-MR (Table 2).
Effect of the Mobile Phone Intervention on Primary and Secondary Outcomes at 2 Weeks and 4 Months Follow-Up
No evidence was found for an effect of the intervention on the primary outcome of LARC use at 4 months post-MR.
The log rank test indicated that there was no evidence for a difference in contraceptive discontinuation rates between the allocation groups (Supplement 3). We found no evidence for a difference in effect of the intervention on LARC use between subgroup categories (Supplement 4).
The intervention appeared to have an effect on reported physical IPV measured using a closed question asking about specific acts (Table 2): 42 (11%) of participants in the intervention arm reported physical IPV in the 4 months post-MR versus 25 (7%) in the control arm (aOR=1.97; 95% CI=1.12 to 3.46; P=.03). A post-hoc analysis using MI (under a weaker missing at random assumption) to handle missing data found participants in the intervention group had 2.16 (95% CI=1.16 to 4.02) times higher odds of reporting physical IPV as participants in the control group. There was no evidence in crude or adjusted models that the intervention had an effect on self-reported sexual IPV (47 [12%] vs. 36 [10%]; aOR=1.25; 95% CI=0.78 to 2.02; P=.23) or self-reported physical violence perpetrated by in-laws (6 [2%] vs. 4 [1%]; aOR=1.20; 95% CI=0.31 to 4.62; P=.54). Reports of adverse outcomes also did not differ when participants were asked whether something happened to them as a result of participating in the study: only 4 participants (2 per group) reported something negative, and all 4 reported pain or other effects of the MR or contraception. Additional analysis of imputed data sets adjusting for imbalances in baseline data had no effect on the scientific conclusions. We found no evidence for a difference in effect of the intervention on physical IPV between subgroup categories (Supplement 5).
The mHealth intervention had an effect on reported physical IPV.
During the 4-month follow-up survey, 319 (85%) intervention and 89 (25%) control participants reported that they received voice messages about family planning since they joined the study. Among intervention participants who received messages, 170 (54%) said they listened to all the messages, 141 (45%) listened to some, and 5 (2%) listened to none. A small number of participants (12 intervention and 1 control participant) reported that they pressed 5 to opt out from receiving further messages.
Women allocated to receive interactive messages about contraception (the intervention group) were more likely to report physical IPV compared with the control group receiving usual care, but there was no evidence of an effect on self-reported LARC or effective modern contraceptive use. The increase in reported physical IPV was observed when measured using a direct question that named specific acts of violence, but no conflict was reported in response to an open question about positive or negative effects of being in the study.
Women who received the messages about contraception reported more physical IPV; LARC and effective modern contraceptive use were not affected.
A key strength of this study is the randomized controlled design, which allowed us to identify an increase in a rare negative outcome; it is unlikely this effect would have been detected in a noncomparative study. The randomization process was conducted remotely, and clinic and research staff involved in recruitment were blinded to allocation as was 1 analyst. While some bias may have been introduced through lack of full blinding in the 4-month survey, steps were taken to ensure that RAs conducting this follow-up interview were blinded during reporting of primary and secondary outcomes, which were placed at the beginning of the questionnaire. Loss to follow-up was relatively small and was similar across arms, and MI (assuming missing at random) was used to handle missing data.
Table 1 shows that baseline differences existed between the 2 allocation groups, which occurred by chance during the randomization process. We adjusted for these differences, and although some residual confounding may have remained, it is very unlikely to affect the results.51 Notably, a higher proportion of patients in the control arm than the intervention arm were using LARCs at baseline (14% vs. 10%, respectively). This is the principal reason why the point estimate from adjusted analysis for LARC use at 4 months and 2 weeks is greater than the corresponding unadjusted point estimate. Given the baseline imbalance, the adjusted results are preferred; however, the difference between the 2 must be interpreted cautiously as the 95% CI from the adjusted analysis includes the unadjusted estimate in each case.
The proportion of control participants using a LARC at 4 months (15%) was higher than predicted during sample size calculations, slightly reducing the power; however, the loss to follow-up was less than expected. Post-hoc power calculations indicate that we had a sample size that was large enough to detect an increase of 9 percentage points at 4 months of follow-up, from 15% in the control group to 24%, and of 8 percentage points to 23% when using multiple imputation. The study was not powered for the subgroup analyses, so we were unlikely to find any significant results in these analyses; however, the results do not appear to explain the increase in IPV.
The main limitation of this study is that all outcomes are self-reported and may have been affected by a number of types of reporting bias; however, self-reporting is standard for trials of interventions to support contraceptive use.8 Recall bias is likely to have affected both allocation groups in the same way, but social desirability bias may have had a differential effect; for example, participants in the intervention group may have felt more pressure to report something positive happened to them as a result of study participation because they received the intervention. Another possibility is that the intervention may have increased trust in the study team, leading intervention participants to feel more able than control participants to report violence.
Control participants were not sent placebo or dummy messages to their phone without active content, which limits our ability to identify whether the increase in IPV was a response to the message content or to getting messages at all. However, given that both the message content and format were integral to the intervention design, we do not consider this as limiting our finding that this mHealth intervention led to an increase in violence. A noteworthy proportion of control participants reported receiving messages about family planning during the study period; it is not clear if these were messages from another source, or whether some participants considered the reminders about the follow-up interviews as family planning messages. Initial analysis of interactive voice response system process data suggest minimal contamination was present, but this possibility is being explored further.
The measures of violence used did not capture frequency or severity, and addition of these outcomes may have provided more insight into the relationship between the intervention and this adverse outcome.
The measures of violence used did not capture frequency or severity.
Discussion in Relation to Existing Literature
No adverse outcomes were reported in a similar study in Cambodia, which improved contraceptive use among postabortion clients using interactive voice messages8; however, only a single open question was used: "Did anything happen to you 'positive or negative' as a result of participating in the trial?" (personal communication with the study principal investigator). In an RCT evaluating instant messages delivered by a mobile phone app designed to increase the acceptability of contraception among young people in Tajikistan, 4 of 470 participants interviewed at follow-up reported experiencing physical violence since being in the study, but there was no evidence for a difference between the control and intervention groups.34 A trial of text message support for adolescents and young adults in the United States using an injectable contraceptive stated that no adverse events were reported by participants; however, no information was given on how such events were measured.35 Other trials of mHealth interventions for contraception have not reported on conflict or violence.25,33,36–41 A 2013 systematic literature review of the effects of mHealth interventions and interventions aimed at increasing mobile phone ownership and use among women on gender relations in developing countries found evidence for both positive and negative effects.31 The included literature suggest that mobile phone interventions can increase women's decision-making power and social status and can increase male participation in health areas usually targeted to women.31 However, in a study in which participants had been given phones as part of the intervention, some tensions over phone use were reported, and an intervention supporting mobile retail business among women led to tension and abuse when a participant's husband's role as the highest earner was challenged.31 The authors identified only 7 articles on this topic that met their inclusion criteria, and they concluded that effects of mHealth on gender relations are often not being measured.31 Qualitative research in Ghana conducted between 1994 and 1996 found that in addition to having many positive effects, the introduction of family planning services in the region led to tensions in gender relations.29 For example, some men reported fears that women using contraception will be unfaithful. There are anecdotal reports of similar attitudes in Bangladesh.
Meaning and Mechanisms
Although a possibility, it is unlikely that the increase in self-reported IPV is a chance finding: the P value of .03 equates to a 1 in 33 chance. As discussed in the limitations section, the result could possibly be due to reporting bias if receipt of the intervention made women feel more able to disclose IPV. The result may reflect a true increase in IPV by one of the following mechanisms. It is plausible that although participants agreed to messages being sent to their phone about contraception and were played an example at recruitment, messages were more troublesome when received at home: messages may have been overheard by others who found the content to be unacceptable, messages may have disclosed contraceptive use, or they may have led to suspicion of infidelity. The messages did not mention the participant's MR or study participation; however, such information may have been revealed if she was questioned about the calls. Notably, concern about family finding out about an MR was a common reason for potential participants refusing to take part in the study.
It is unlikely that the increase in self-reported IPV is a chance finding.
In Bangladesh, not seeking a husband's permission before making a decision is often reported to warrant wife-beating,47 and a husband's lack of approval was also given as a reason for refusal to participate in the study. Women were given the opportunity of enrolling with their husband or of informing him before they agreed to participate, but some of those who did not get their husband's consent could have experienced IPV. Conflict may also have resulted from increased phone use, from calls coming from an unknown number, or from the timing or repetitive nature of calls. IPV may plausibly occur in interventions that empower women to use contraception, thereby challenging existing power dynamics; however, there is no evidence to support this mechanism in this trial.
No participant reported violence in response to the open question about study effects, and intervention participants were more likely than control participants to report a positive experience. This result may reflect acquiescence bias, social desirability bias, or concerns that the conversation was being overheard. It is also possible that participants did not attribute violence that they may have experienced to the intervention. Reported levels of violence were higher at baseline than at 4 months but this is to be expected for the following 2 reasons. First, different time frames were used for the baseline and 4-month surveys; at baseline participants were asked about violence in the past year in order to be able to compare the level of violence in this population with other surveys and because a 12-month follow up was planned, as explained below. At follow-up, participants were asked about violence during the intervention period—the past 4 months—in order to examine any difference in relation to study participation. Second, there is evidence demonstrating unintended pregnancy and abortion are associated with partner violence. Therefore, we may expect to see higher than normal levels of violence when interviewing women at the time of an MR procedure.51
The study protocol included a quantitative 12-month phone follow-up and in-depth interviews with a small number of participants.46 The 4-month primary outcome data were analyzed before the 12-month survey was conducted in order to inform programming at MSB. After observing the increase in physical IPV and the lack of benefits from receiving the intervention, the findings were shared with the 4 ethics committees who had approved the protocol. A decision was made not to proceed with the 12-month survey due to safety concerns; although the intervention had ended, it was unclear whether the study participation itself was a potential cause of risk. The in-depth interviews, which had been planned as part of a mixed-methods process evaluation, were redesigned to explore the violence outcome and to increase safety protocols when recontacting and interviewing trial participants. The interviews, conducted in 2017, are currently being analyzed and full results will be reported elsewhere. No in-depth interview participant reported conflict or violence resulting from study participation. However, the possibility exists that anyone who experienced conflict may not have agreed to an in-person interview. In the interviews, women reported that phone sharing with husbands was common, so the possibility of messages being overheard was high. There was some evidence of women's phone calls being monitored, and there were a few cases of marital conflict due to phone use more broadly. A number of participants reported not talking about the study due to concern that it would result in other family members or people in the local community finding out about their MR. The majority of participants interviewed had informed their husband about their MR and the study, but many had not shared this information with their in-laws or others. Many reported opposition to MR among other family members and the wider community. The lack of effect of our intervention on contraceptive use is also important. This finding contrasts with results from voice call interventions that increased contraceptive use among postabortion clients in the study in Cambodia discussed earlier and among postpartum clients in Ecuador.8,26 The lack of effect in our study may be due to differences in the intervention design, the context, or both. Self-reported process data indicate that the majority of participants listened to some or all of the messages, suggesting that the lack of effect was not due to non-receipt of messages. Both the Cambodian and Ecuadorian interventions relied heavily on individualized counseling, and although our messages linked participants to a call center, we aimed to explore the effect of automated content and placed this at the start of the call because counselor-intensive interventions are more costly to provide at scale.26,43 Furthermore in Cambodia, but not in Bangladesh, counselors were able to book clinic appointments, which may have helped to translate behavioral intentions into actions.43
Text and voice-based interventions with proven effectiveness have used messages that are short in length,8,16 and recipients have reported that getting only small amounts of information at a time facilitates the assimilation of new content.15 In contrast, each of our messages contained many ideas. The temporary nature of automated voice messages may make them unsuitable for delivery of complex information because they cannot be revisited after the call has ended and content may be missed if the call comes at an inconvenient time.
Our messages may not have contained the correct content or a sufficient amount of information to adequately address established individual or social barriers to contraceptive use in this population, such as health concerns.1,7 However, interpersonal factors and social norms may limit the effectiveness of interventions targeting the individual in Bangladesh, where 35% of married women report that decisions about their own health are made mainly by their husband or someone else.1 This influence may be particularly relevant for LARCs; in a recent survey in one area of the country, 64% of women reported that their husband disapproves of the implant and the IUD, compared with 8% for the pill.7
Twenty-five percent of control participants reported receiving voice messages about family planning during the study period. Prior to the trial, some MSB trial clinics made phone calls to MR participants after their procedure to provide follow-up support, including for contraceptive use. Clinics were asked to stop this practice during the trial, but it is possible that some calls may have been made. Such calls may have weakened any intervention effect.
Implications for Research and Services
Caution is needed when conducting follow-up of clients who have accessed sexual and reproductive health services, both for programming and research purposes, and with development of other mHealth interventions in this field. A simple call from a provider, rather than automated content, would allow the caller to check who is speaking before revealing their identity and the purpose of the call. The use of "withheld" numbers are recommended for outbound calling as are scripts ensuring confidentiality. Where appropriate, callers may be trained to give a "cover story" in case the call is interrupted. It is vital that mHealth reproductive services are "opt in" and that participants have adequate opportunity to opt out once the intervention has started. Programmers may also consider the possibility of offering alternative delivery mechanisms to women who think their partner may object to the phone calls. With respect to family planning, content that does not reveal contraceptive use may be less personal but could be safer. However, it may be preferable, and still effective,8 to avoid any reference to the topic of the call and to use neutral outbound messages only as a way to maximize call center use, particularly when targeting women at a sensitive time in their lives such as post-MR. Studies need to explore how call center counselor-intensive interventions could be financed at scale, for example, via government support, discounted mobile operator charges, corporate sponsorship, and user payment, although the latter must be investigated carefully to ensure it does not negatively affect use or exclude certain groups.22 Where smartphones are widely available and illiteracy is not a barrier, apps that can be password protected may offer more options for privacy because women will be able to seek information on their own terms. When developing theoretical frameworks of intended intervention mechanisms, it is also important to consider what unintended and harmful outcomes are possible and how they could occur.32 In addition to supporting efforts to reduce intervention risks during the design phase, this consideration can inform the rigorous measurement of potential adverse outcomes and exploration of the mechanisms behind them.32
Caution is needed when conducting follow-up of clients who have accessed sexual and reproductive health services.
The increase in self-reported violence against women who received automated, interactive voice messages about contraception, despite strong privacy and screening measures, demonstrates the importance of carefully considering the potential for negative outcomes and their underlying mechanisms when developing interventions on sensitive reproductive health topics. The findings also highlight the need to routinely include specific measures with named acts of violence when evaluating mHealth interventions on sexual and reproductive health. We recommend that future mHealth studies set up data safety monitoring boards or make a data and safety monitoring plan to review preliminary effects of the intervention on safety outcomes. Analysis of process data from this trial to explore the mechanism behind the violence outcome and reasons for the noneffect on contraceptive use will be reported elsewhere. That report will include process data from the interactive voice response phone system and from in-depth interviews with study participants.
The study findings highlight the need to routinely include specific measures with named acts of violence when evaluating mHealth interventions on sexual and reproductive health.
We would like to acknowledge the support of the study advisory committee in Bangladesh, including Zakia Achter, Deputy Director (Program Manager) IEM Unit, Directorate General of Family Planning (DGFP), and Dr. Rezaul Islam, Deputy Director (Hospital) Directorate General of Health Services (DGHS), who reviewed the study protocol and Dr. Pabitra Kumar Sikder, Deputy Director and Program Manager (MNCH), DGHS who reviewed the initial intervention design. We would also like to acknowledge the STEP-UP consortium partner organizations and consortium advisory group for their support during the study design, implementation, and interpretation of the results; Caroline Free, who reviewed the study protocol, intervention design, and content; Jennifer Gassner for supporting the intervention design; Sadid Nuremowla, Pronab Chowdhury, Mohammad Zobair, and Arunima Islam for their support in the intervention design and with implementing the study; "I am digital" for building and hosting the intervention; Barek Hossain Mithu for overseeing the data entry; and Emma Slaymaker for advising on the discontinuation analysis.
Funding: This study is funded by UK aid from the UK government. It was part-funded through the Strengthening Evidence for Programming on Unintended Pregnancy (STEP-UP) Research Consortium, managed by the Population Council. KR was funded by an ESRC PhD fellowship.
Disclaimer: The views expressed do not necessarily reflect the official policies of the UK government.
Competing Interests: KR, FT, TDN, SB, KF, KK, MD, YR, and KC were employed by Marie Stopes International or Marie Stopes Bangladesh and KA, EP, KB and JM by Ipas or Ipas Bangladesh as staff members and/or consultants while working on this study. Marie Stopes International, Marie Stopes Bangladesh, Ipas, and Ipas Bangladesh were responsible for the design and implementation of the intervention being evaluated. The other authors declare no conflict of interest.
Cite this article as: Reiss K, Andersen K, Pearson E, et al. Unintended consequences of mHealth interactive voice messages promoting contraceptive use after menstrual regulation in Bangladesh: intimate partner violence results from a randomized controlled trial. Glob Health Sci Pract. 2019;7(3):386-403. https://doi.org/10.9745/GHSP-D-19-00015
Received: 2019 Jan 2.
Accepted: 2019 May 21.
Published: 2019 Sep 23.
© Reiss et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/. When linking to this article, please use the following permanent link: https://doi.org/10.9745/GHSP-D-19-00015
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. Text messaging, teen outreach program, and sexual health behavior: a cluster randomized trial. Am J Public Health. 2016;106(S1):S117–S124. doi:10.2105/AJPH.2016.303363. pmid:27689478
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. The effect of drug consultation center guidance on contraceptive use among women using isotretinoin: a randomized, controlled study. J Womens Health (Larchmt). 2008;17(4):579–584. doi:10.1089/jwh.2007.0623. pmid:18447762
Harrington EK
. Evaluation of an mHealth SMS Dialogue Strategy to Meet Women's and Couples' Postpartum Contraceptive Needs in Kenya (Mobile WACh XY): A Randomized Controlled Trial [master's thesis]. Seattle: University of Washington; 2017. https://digital.lib.washington.edu/researchworks/handle/1773/41691. Accessed June 21, 2019.
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. Using daily text-message reminders to improve adherence with oral contraceptives: a randomized controlled trial. Obstet Gynecol. 2010;116(3):633–640. doi:10.1097/AOG.0b013e3181eb6b0f. pmid:20733446
Halpern V,
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. Strategies to improve adherence and acceptability of hormonal methods of contraception. Cochrane Database Syst Rev. 2013;(10):CD004317. doi:10.1002/14651858.CD004317.pub4. pmid:24163097
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. Process evaluation of a mobile phone-based intervention to support post-abortion contraception in Cambodia. Contracept Reprod Med. 2017;2(1):16. doi:10.1186/s40834-017-0043-8. pmid:29201421
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. The Behaviour Change Wheel: A Guide to Designing Interventions. Surrey, UK: Silverback Publishing; 2014.
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. Using automated voice messages linked to telephone counselling to increase post-menstrual regulation contraceptive uptake and continuation in Bangladesh: study protocol for a randomised controlled trial. BMC Public Health. 2017;17(1):769. doi:10.1186/s12889-017-4703-z. pmid:28974209
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. Understanding Intimate Partner Violence in Rural Bangladesh: Prevention and Response. London, UK: Overseas Development Institute; 2017. https://www.odi.org/sites/odi.org.uk/files/resource-documents/11517.pdf. Accessed June 21, 2019.
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MISSISSIPPI Unit Receipts
Three Receipts for the 2nd Mississippi Infantry. All three are for military items issued in May 1861 to the 2nd Mississippi regiment in Virginia: bayonet scabbards, cartridge boxes, cartridge box belts, and more. Signed by 1st Lt. H. S. Holland, "Commanding Beck Rifles"; Captain John H. Booth, "Commanding Calhoun Rifles"; and S. H. Taylor, "Commanding Coonewah Rifles." All are on ruled paper with only minor soiling.
April 30 Finished organization at Corinth, Mississip
May 3 Elected Colonel William C. Falkner, Lieutenant Colonel Bartley Barry Boone, Major David W. Humphreys, and Adjutant Lawson B. Hovis
May 5-10 Moved by rail to Lynchburg, Virginia in two sections, Companies A,C,D,F & I under Lt. Colonel Boone and Companies B,E,G,H & K under Colonel Falkner.
May 10 Camped at Camp Walker outside Lynchburg and mustered into Confederate States service for one year.
May 17-18 Ordered to Harpers Ferry with the 11th Mississippi Regiment and the 2nd Mississipi Battalion and moved to Strasburg, Virginia by rail.
May 19-20 Marched to Winchester, then moved by rail to Harpers Ferry. Camped on Bolivar Heights.
May 23 The Inspector General reported that the regiment was not happy with its flintlock smoothbore muskets, had a "slovenly and unsoldierlike appearance," and had "come away from home without making proper preparation" for "almost every necesssity of clothing."
June 15 Withdrew from Harpers Ferry with Johnston's Army to Camp Johnston, near Winchester.
June 16 Moved to Bunker Hill and camped on Mill Creek.
June 18 Moved on the Valley Pike to Camp Bee at Winchester. Colonel Falkner was put in command of a brigade consisting of the regiment, the 11th Mississippi, the 4th Alabama and the 1st Tennessee.
June19 General Bernard Bee took command of the brigade. Colonel Falkner returned to command of the regiment.
June 28-29 Moved by rail to Harpers Ferry. At Harpers Ferry the regiment burned railroad cars on the Baltimore & Ohio Railroad, then marched to Hallstown. It then returned by rail to Winchester.
July 2-3 Moved to Darkesville in an overnight march.
July 7 Returned to Winchester.
July 18 Ordered to support Beauregard at Manassas. The sick were left at Winchester and the regiment marched through Ashby's Gap to Piedmont, where with two companies of the 11th Mississippi, and Generals Johnston and Bee it boarded a train for Manassas.
July 20 Arrived at Manassas about noon. The regiment was put in a suporting position behind McLean's and Blackburn's Fords on Bull Run.
Battle of Manassas (Bull Run)
The regiment was sent to reinforce the endangered left flank. It arrived at the scene of the fighting around 11, crossing Young's Branch and forming a defensive line that was supported by two batteries. Under heavy small arms and artillery fire that mortally wounded General Bee, the regiment fell back with heavy losses and reformed behind Jackson's Brigade. It then joined Jackson in the attack on the Union batteries. Major Whiting gave the 2nd Mississippi credit for the capture of Rickett's Federal Battery. The regiment lost 25 men killed, and 82 men wounded. Colonel Falkner and Sergeant Major John Blair were wounded, and Lieutenant Colonel Bartley Boone was captured.


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Uni isn't for everyone and that's OK
Our Music Editor talks us through the highs and lows of University, dropping out and how you don't need to have a degree to achieve success
Feature by Tallah Brash | 26 Sep 2019
In early 2000, poised before the difficult decision of what course to study at University, I got myself in a pickle. Well and truly confused, I found myself applying for six completely different courses: Computer Arts at Dundee's Abertay University (I never went to the interview), Interdisciplinary Design at Edinburgh Napier University, two different courses at the Edinburgh College of Art and two at the University of Edinburgh – Music (I didn't go to the audition) and Architecture (I accepted a place and quit less than two years into the course). What a total shitshow it all was. I was 17 years old – how the fuck was I suppose to know what I wanted to do with the rest of my life?
I have to admit up front, I didn't have the most relatable of high school experiences. I was once a highly competitive archer, which found me travelling a lot in my teens with the Junior British Archery Team, and Scottish Junior and Senior teams. An abnormal amount of pressure had, therefore, already been placed on me from an early age – I sat two of my Standard Grade exams in a hotel room in Italy for fuck's sake – and then I had to figure out what to do after school. With archery, I was working towards hopefully one day competing in the Olympics, and The University of Edinburgh had the best Archery Club of everywhere I'd applied for so I guess that's why I ended up there? Either that or I was just drawn to subjects beginning with the word 'arch'.
In an ideal world, I'd have taken a year out, but no one from my family had ever gone to uni before (hello extra pressure). I'd grown up in council housing with my parents constantly struggling to give me the best life and at the end of the day they just wanted what was best for me, which they thought was higher education, so convinced me otherwise. I'm now 37, I haven't done archery for at least 16 years, I didn't go to the Olympics and I don't have a degree. But, and this is a big but, that doesn't make me a failure.
In 2002 I dropped out of uni. While I was managing to hold down a part-time job and doing reasonably well on the course, I was so deeply unhappy to a point where it was downright unhealthy. I was staying up late to finish coursework and then sleeping in and missing classes – it was a vicious cycle. Then, one night when I was drunk, on my way home from a club I went into the studio and coloured in all of my technical drawings (24 hour access was both a blessing and a curse) the night before I had to give a presentation! It was not a good look. I somehow got away with it, but immediately booked an appointment with my Director of Studies as I realised I'd gotten myself into a mess and didn't particularly want to continue on the course. He immediately pointed out the glaringly obvious – I was depressed.
After trying to convince me to stay – "but you bring something different to the course" – he helped me try to transfer onto a different course (Primary School Teaching for some reason) which led to rejection. He did everything he could to help me and then I just stopped going into uni altogether, and I stopped archery. I was miserable. I felt like a failure, like I'd let everyone down, but my mum made everything seem okay. It turns out she just wanted me to be happy all along (of course she did) and the degree didn't matter. I told my mum I'd taken on full-time hours in the cinema where I worked until I figured things out. Her response: "As long as you're happy."
As long as you're happy. Five such simple words that have stuck with me since that day. I went from the Odeon to working in a bank (hated it), from the bank to Monsoon/Accessorize and from there to a whole big world of music. As a non-student I became a member of Fresh Air, Edinburgh Uni's student radio station and that was my turning point. I started a show with my friend and found myself applying for a Creative Industries HND in Radio at Edinburgh's Telford College, which I fucking well completed. Self high five! Fresh Air changed everything for me and it was like setting off an elaborate sequence of falling dominoes. Quitting uni was the best thing I ever did.
While it's impossible to list everything here that I've done since I quit uni, I'm now the Music Editor for The Skinny and can without hesitation say I made the right call back in 2002; I have no regrets. I was employed at The Skinny based on my knowledge and experience, not on whether or not I had a degree. I've worked my way through various areas of the music industry over the years, offered my services for free, learning as much as I could along the way and fortunately it has led me here. It has been hard, but so is getting a degree. I'm now doing something I feel passionate about and I'm privileged to do what I do for a living.
So if you've just started uni, it is absolutely, unequivocally, more than OK if you're not sure you've made the right decision yet. Seriously. Anything you're doing is helping shape your future, and if you're anything like my boyfriend you might end up with a degree in Marine Biology but could become an award-winning baker. Stay true to you, and make sure what you're doing feels right and if it doesn't, you feel stuck in a rut or not like yourself, talk to someone.
"Please, please go with your gut. I left school three months before I was due to take my A Level exams with every odd stacked against me. My mental and physical health was a mess. I knew that I was at a crossroad with all signs pointing straight but my heart just wasn't in it. There is no better time to be selfish [...] Don't waste time pondering your future, go and start building it!" Daisy Maskell, Breakfast Presenter, Kiss FM
"I am in no way claiming to have 'made it' but I am super proud of what I've done. At school I was offered four unconditionals which I rejected to do a three-day-a-week HND at Edinburgh College. Studying Music Business I got the whole 'where is that going to take you?' chat or 'so when do you go to uni?' I'm 20 and I get hired on my experience and drive not a piece of paper I hold, or in this case lack of." Jo Dargie, Co-Manager/Director, Discovery Music Scotland
"Get a job, work hard. Four or five years of experience and ladder-climbing will serve you better than four or five years of study. Sure certain professions demand a university degree but I know that a degree would have done nothing to enhance my career. It sure as hell saved me several thousand pounds, it meant I could enjoy my early 20s and I learned an awful lot in those formative years in the industry." Ian Smith, Founder, Last Night from Glasgow
"I stumbled through school, crippled by what I now know is dyslexia. I started in the Civil Service straight from school but from my first glimpses of glam rock on Top of the Pops and seeing my first live band music was in my blood. After playing guitar badly for years, running community music groups and a festival on a voluntary basis, I now run Mac Arts and I still can't believe that this is called a job." Chris Wemyss, Venue Manager, Mac Arts, Galashiels
Don't Suffer in Silence
If you're feeling overwhelmed, like you're struggling, or in desperate need of advice or help, talk to someone – that could be your Director of Studies, a tutor, your University's Student Council Service, your GP, a family member or a friend. Alternatively, here are some helpful websites to consider.
Nightline: nightline.ac.uk
National Union of Students: nus.org.uk
Student Minds: studentminds.org.uk
Scottish Association for Mental Health: samh.org.uk
Samaritans: samaritans.org
Tiny Changes: maketinychanges.co.uk
Mind: mind.org.uk


Advanced technology in high output LED's has led to the development of what can be regarded as the ultimate rear combination lamp for light commercials, I tonners, camper vans, all trailer types and boat trailers in particular.
Designed and manufactured by Brown & Watson on the footprint of Australasia's popular rear combination lamp, Model 42 released from Narva offers a totally new approach to rear multi-voltage lighting. This innovative Australian design with universal applications is one of the first to incorporate an integrated LED reverse lamp.
With the design registered in Europe, the lamp is fully E and ADR compliant and already orders are flowing from Europe and other parts of the world.
Constructed of virtually unbreakable polycarbonate with inbuilt reflex reflectors, stainless steel fittings and sonically sealed with 0.5metres of hard-wired cable, the lamps will withstand the harsh commercial environment. The lamps are free from the problem of water and dust ingress.
Competitively priced, utilising the new LED technology, Model 42 lamps are available in a rear combination of stop, tail and direction indicator with reflectors, or stop, tail, direction indicator and reverse lamp with reflex reflectors. With a depth of just 35mm, both versions of the low profile lamps are also multi-voltage 9-33 volts.
Answering the prayers of every boat owner, a special kit is also available under a Narva Marine Part No. 94206TP. This includes two submersible Model 42 stop, tail, direction indicator lamps, hard-wired with 9 metres of cable coupled with an ADR compliant sealed licence plate lamp, also with 9 metres of hard wired cable. This combination allows additional electrical connections to be made at the towing vehicle, well beyond the trailer submersion level, virtually eliminating corrosion, electrical faults and early failure.
The new Model 42 Narva lamps are available from automotive, transport, marine and 4WD outlets throughout Australasia.


Reinstating university professors and administrators dismissed or forced into retirement for their political views.
Have you spotted a promise in action?
See something wrong? Share data to help fact-check a promise!


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Pope invites young people to join global prayer network online
By Carol Glatz • Catholic News Service • Posted January 22, 2019
VATICAN CITY (CNS) — Pope Francis helped launch a new mobile app and online platform connecting people around the world in prayer.
The pope presented "the official platform of the Pope's Worldwide Prayer Network: Click To Pray," Jan. 20 after praying the Angelus with visitors gathered in St. Peter's Square.
Joined by Jesuit Father Frederic Fornos, head of the international prayer network, holding a tablet displaying the platform, the pope said it would be "here that I add my intentions and prayer requests for the church's mission."
The prayer network, formerly called the Apostleship of Prayer, is a Jesuit-run outreach that has given Catholics the pope's monthly prayer intentions since 1890. The global prayer network started offering the prayer intentions on video over social media in 2016.
"I above all invite you, young people, to download the app, Click To Pray," the pope said, asking them to keep "praying together with me the rosary for peace, especially during World Youth Day in Panama" Jan. 22-27.
"Internet and social media are a resource in our era, a chance to stay in touch with others, to share values and plans and to express the desire to be a community. The web can also help us pray as a community, to pray together," he said.
The website www.clicktopray.org and the mobile app — available for Android and iOS — are offered in six languages: Spanish, English, Italian, French, Portuguese and German. A version will soon be available in Vietnamese and Chinese, the site said.
Users are invited to "pray with the pope" using his monthly prayer intentions, to "pray every day" by receiving notifications and inspirational thoughts for prayer or reflection three times a day and to "pray with the network" where users, including Pope Francis, can share their prayers with others.
PREVIOUS: Different nations, but one faith unites Panama's World Youth Day pilgrims
NEXT: Pope says he's pained by deaths in Colombia, the Mediterranean


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For your optimum viewing pleasure,
switch the font on your email program
to Courier New, size 10.
or not…whatever.
Some regular features have been deleted in this issue due to the fact
that there was only 1 one ONE!!!!! submission out of roughly 800 of you.
TOUR DATES: (NEW DATES MARKED WITH A **)
**August 27- Ottawa Civic Centre Theater, Ottawa, Ontario, Canada
(O,P)** CONFIRMED
The Quote Of The Day:
Life was fun life was great
til I made my big mistake
oh no it'll never happen to me
life was short and life was sweet
-From Out The Window
-Submitted by Jamie.Stinson
–Send your VF quotes to patwary
ALL CORRESPONDENCE CONCERNING THIS LETTER SHOULD BE DIRECTED TO
PATWARY
In Today's Issue:
DC to WV Info Needed
The Camden Show
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Pat, please add this to the next American Music newsletter:
Anyone from the Washington D.C. area planning on going to the West Virginia
show? Does anyone know how long it would take to get there from D.C.?
Eor24
Well, folks, this was a weird one.
We got to the venue before the first show, and since the ECenter page
said that no more tickets were available I was expecting a huge crowd.
I couldn't have been more wrong. The place was almost deserted. It must
have been that fans of certain acts hung around mainly for that one act
and then wandered around. This venue was very strange. There was an
enclosed part and then the lawn part, which was waaaayyyy the hell away
from the stage. The enclosed part was all seats, with no place to get
up front close to the stage. Cameras were not allowed without a photo
pass, and not even for those lucky ones with backstage passes could
bring in a camera. Despite the tight restrictions, alcohol (beer,wine,
mixed drinks) was available for purchase, and I did notice a couple of
people who were more than willing to spend enough money ($6/beer?) to
get good and shitfaced.
As for the acts, they were all very good. I had seen Jonatha Brooke in
Newport last year, but had more of a chance to enjoy her act this time.
The Radiators were very, very good, although it wasn't quite the sort
of music I usually enjoy. David Bromberg was most excellent. I'm
sorry it took me 20 years to finally see him. Unfortunately he only
played for 20 minutes, but the last song especially was unbelievable.
He was accompanied during that song by the Radiators, and it was
great. Indescribably so.
Now for the Violent Femmes review. Well, hell. They are always great,
aren't they? Brian mentioned at some point during the show something to
the effect that it was the oldest audience for which they had ever
played, and yes, it was true. Some people absolutely did not know
what to think of them, because their range of musical styles made them
impossible to pigeonhole. And then there were others who knew every
word, at least every word to the older songs. Yes, the people on the
lawn crowded as far into the pavillion section as they could to dance
and sing along, and most of the people in the seats were swaying to the
music. One guy had his daughter with him; she was probably no more
than 18 months old, and she was just dancing up a storm, really loving
Now, for the set list. They only played for about 45 minutes,
so I'm going to go ahead and list the whole thing:
Country Death Song
Rejoice and Be Happy
Hey Nonny Nonny
Jesus Walking on the Water
Old Mother Reagan (ok let me break here and tell you that Brian really
cut loose on this song. He was just screaming the backup vocal
and it was so funny. What a ham. Austin and Ethan were just
about rolling on the floor with laughter.)
Dahmer is Dead
Chikugo Sashi (Brian solo with Shakuhachi. Eat your heart out Deana. It
was great)
Good Feeling
Short but sweet. We had to leave after Rickie Lee Jones' act, because
it was after 8; we had a 2-3 hour drive home, and two young boys who
need to get to bed at a decent hour. So we missed the last three acts,
all of which I had seen in Newport anyway. It was too bad, but what
are you gonna do, eh?
Now, let me say that this was the first show of the tour and it does
appear as if the Newport Folk people have to iron out a few wrinkles.
Personally I think they should have done things just as it is done in
Newport itself. After all, they've had more than 30 years to get it
right. Maybe it was just that particular venue.
At any rate, the acts are all worth seeing, and I will still recommend
this tour to anyone who has or will be getting tickets.
Oh, yes, I did mention in a previous issue that Austin wanted the band
to sign his cast. He is now possibly the only 10 year old in the world,
maybe even in the history of the world, to have a cast signed by every
member of the band, plus Willie and Caleb.