REI recently posted an entry by Florence Williams on their blog, titled "The Nature Fix: The Three-Day Effect," about studies being done on the neurological benefits of unplugging completely and spending time outdoors. This is on top of multiple studies done over the last few years, and a recent Time article, also by Williams, suggesting that even 15 minutes of time spent in nature–and not just the wild, but a green area–is beneficial to memory and anxiety.
Anecdotally, I can say that my depression absolutely got worse when I moved away from natural spaces.
I grew up largely in a rural environment. When I was very young we lived in suburbia, but my late childhood and adolescence were spent in a place where I couldn't hear any highway traffic outside, we could see the neighbors houses through the trees–in the winter, and if you forgot something at the store, you just did without. The only way to get cable was through satellite, and that wasn't available until several years after we moved, my parents were on dial-up internet until I was in college, and by the time they moved out of that house you still had to go outside to get decent cell reception. Realistically we weren't super-remote. We were still 15 minutes from town, and half an hour from major shopping and dining areas. But my childhood was defined by the freedom of (mostly) unsupervised outdoor play.
But then I look at my life now, and I wonder, how have I gotten so far away from nature?
Some of it is me. But a lot of it is a cultural problem.
Work, for one. If people were expected to take their work with them when they went on vacation before smart phones, now the expectation is as simple as muscle memory. We have cell reception and data service in many remote wilderness spaces now, so "going on vacation" still comes with the responsibility of checking emails–even if you just forward it to a coworker, the attachment is there. Myself and nearly all of the working adults I know have said they prefer checking email while on vacation because otherwise they come back to so much backlog the week after vacation is so stressful it feels like you shouldn't have even taken one. That's the ridiculous working culture in the United States right now.
The speed of information for another. I frequently have to take breaks from Facebook–whether it's for the length of my workday, the length of the calendar day, or several days at a time–just because the constant onslaught of breaking news, memes, and occasionally even updates on people's personal lives just becomes overwhelming. But that's the speed that we move at. Whenever I take those breaks, I feel like I have to spend just as much time catching up on everything I missed, or just stay permanently out of that particular part of the internet (which is more often than not what I do–sorry tumblr friends!).
And as easy as it should be to fix that second one–I'm in control of my own internet usage after all, aren't I?–the internet is such a permanent fixture of communication that it's hard to step away completely. Whether it's habit–grabbing my phone to look at the weather forecast and then mindlessly opening a social media app; pleasure–I want so badly to participate with the Richmond chapter of Hike-It Baby, but hikes are posted online, and up-to-date information about meeting places are discussed on Facebook; or business–in order to communicate with clients and try and network and build a reputation, Facebook and Instagram are as essential as email is to my desk job–our world is now build around digital communication.
Can you break free? Yes. Should you? Also yes. Probably.
Sometimes it feels like, being an urban resident, that I have two lives. I have my regular life, reliant on technology and never more than a few feet away from my phone, and I have my outdoor life, filled with deep breaths and the sound of the wind in the trees.
What I need to do, is to stop craving the outdoor life and seeing it as something separate, something I have to plan for and escape to, and work out a way to find it during the day.
And I think for me that means leaning how to use social media as a business tool rather than as a personal tool. Something I can leave behind, when I'm not actively working.


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Whisky Review: Crown Royal Peach Flavored Whisky
Canadian, Reviews | December 10, 2022
Editor's Note: This whisky was provided to us as a review sample by Crown Royal. This in no way, per our editorial policies, influenced the final outcome of this review. It should also be noted that by clicking the buy link towards the bottom of this review our site receives a small referral payment which helps to support, but not influence, our editorial and other costs.
Crown Royal Blended Canadian Whisky was first introduced in Canada in 1939 to commemorate the royal visit of England's King George VI and Queen Elizabeth, who were touring the country that year. The tour, which also included an historically groundbreaking visit to the U.S. at the invitation of President Franklin D. Roosevelt, marked the first time anyone from the reigning British monarchy had visited Canada or the United States.
Canada's Crown Royal wasn't offered in America or internationally until 1964, at which time it was well received and quickly gained in popularity among whisky enthusiasts for its approachability and smoothness.
Similar to the success of Crown Royal's flagship whisky, Crown Royal Peach Flavored Whisky also received a welcome reception when it was initially released nearly a century later in 2019. In fact, some retailers reportedly had a hard time keeping it on the shelves, which led to limiting the number of bottles customers were allowed to purchase to two at a time in some U.S. locations.
With its bottling at 70 proof, Crown Royal Peach Flavored Whisky is accessible to a wider audience and is ideal for mixing in cocktails. This Canadian whisky is produced at the Crown Royal Distilling Company in Gimli, Manitoba using Crown Royal's unique column distillation process and meticulous whisky blending methods. Crown Royal Peach is a blend of whiskies, which are specially selected by Gimli distillery's master blender, that have been infused with fresh Georgia peach flavor.
Whiskey Review: Old Elk Double Wheat
Around 80% of the grains used in Crown Royal's whiskies are sourced from Manitoba and nearby provinces. Other expressions in Crown Royal's Flavor Series include Crown Royal Regal Apple, Crown Royal Vanilla, and Crown Royal Salted Caramel.
In a prepared statement Sophie Kelly, Senior Vice President of Whisk(e)y at Diageo North America said, "As a leader in the whisky business, Crown Royal continues to take pride in ensuring we are ahead of the trends and creating high-quality products that help feed whisky drinkers' desire to experiment."
Crown Royal Peach Flavored Whisky was first released by the Crown Royal Distilling Company as a limited edition expression in early Spring of 2019. It was re-released in 2020 for the summer season due to its high demand and is now available year round.
Crown Royal Peach Flavored Whisky (image via Jennifer Williams/The Whiskey Wash)
Tasting Notes: Crown Royal Peach Flavored Whisky
Vital Stats: 70 proof (35% ABV), 750ml MSRP $32, product of Canada.
Appearance: Russet.
Nose: Sweet, fruity aroma with notes of lemon citrus, vanilla, and warm oaky spice.
Palate: Sweet flavors of peach with notes of butterscotch, sweet iced tea, and a hint of caramel.
This peach flavored whisky has a smooth, slightly spicy, creamy finish with a lingering sugary syrup flavor similar to the taste left on the palate after sucking on a butterscotch hard candy. It's very sweet, which may be ideal for drinkers with an insatiable sweet tooth.
Overall, the sweet peach flavor overpowers the essence of the whisky leaving only a minimal flavor profile reminiscent of the taste of Juicy Fruit gum before it loses its sweetness.
Jennifer Williams is a former Dallas, Texas bartender of 15 years where she developed an appreciation for patrons with a healthy respect for great whiskey. She moved to Portland, Oregon in 2019 where she graduated from Portland State University as an English Literature major with a minor in Writing. While...
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Women's Day 2019On the 8th of March, 2019, Women's day, the Internal Complaints Committee organized an inspiring talk by Ms. Madhuvanti Date, faculty of SVKM's Usha Pravin Gandhi College of ……………………..
It was a session that many of us will remember for a long time. Ms. Date is a cancer survivor and spoke from her heart about her experiences, the initial denial, 'why me' period (which she later changed to 'try me' – a challenge to cancer), acceptance of the situation, taking one step at a time and 'charging her battery' each minute in her own words. She realized that being strong and having a positive attitude was her only choice. She held the attention of the audience with her story about how a combination of being strong and happy helped her take the cancer head on. She decided to befriend the otherwise-scary chemotherapy and radiation sessions, lived in the present, removed the 'if-only', and reaped the benefits of gratitude and 'happitude'.
Her belief in affirmations, yoga, meditation, believing in the power of self, positive visualizations, blocking the mental chatter and feeling of abundance, along with regular health checkups and nutrition care helped her tide over the challenging period. The audience re-learnt the value of each healthy day and realized that challenges can be conquered with positivity.


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text:
Bexarotene
The purpose of today's study was to examine the consequences of
Bessie Silva Blogging February 22, 2019 Bexarotene, Rabbit Polyclonal to BST2	0 Comment
The purpose of today's study was to examine the consequences of N-methylaspartate (NMDA) receptor antagonistsmemantine and ketamine as well as the drugs modifying the NO:cGMP pathwayNG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), the endogenous precursor of NO-L-arginine, as well as the guanylyl cyclase inhibitormethylene blue (MB) around the development of sensitization to withdrawal signs precipitated after chronic, interrupted treatment with diazepam, a benzodiazepine receptor agonist, in mice. benzodiazepine receptor antagonist, flumazenil (5.0?mg/kg, ip), were administered following the last shot of diazepam or saline. Memantine (2.5, 5.0?mg/kg), and ketamine (2.5, 5.0?mg/kg), L-NAME (100, 200?mg/kg) and 7-NI (20 and 40?mg/kg), L-arginine (250, 500?mg/kg) and MB (5 and 10?mg/kg) were administered ip in sporadically diazepam-treated mice through the diazepam-free intervals. Our outcomes indicated that both NMDA receptor antagonists and medicines that inhibit the NO:cGMP pathway, except L-arginine (the endogenous donor of NO), attenuated the diazepam-induced sensitization to drawback indicators in mice. Therefore, NMDA receptors as well as the NO:cGMP pathway get excited about the systems of sensitization to benzodiazepine drawback. strong course="kwd-title" Keywords: Diazepam, Sensitization, Withdrawal, NMDA receptor, NO:cGMP pathway Intro Benzodiazepines are trusted in the treating Bexarotene stress disorders and rest disturbances. Their medical efficacy is principally from the inhibitory activity of the -aminobutyric acidity (GABA). Benzodiazepines bind to a particular site around the GABAA receptors that are broadly distributed in the postsynaptic neurons and present high affinity to the drug family members. Molecular studies exhibited great variety in GABAA receptors framework, distribution, and working. For instance, GABAA receptors which contain 1, 2, 3, or 5 subunits are diazepam-sensitive, whereas the ones that contain 4 or 6 subunits are diazepam-insensitive. The primary drawback of the long term administration of benzodiazepines may be the advancement of physical dependence and tolerance with their sedative, muscle mass relaxant and anticonvulsant activity, which limit the medical relevance in the long-term treatment (Allison and Pratt 2003). Furthermore, an abrupt cessation of treatment with benzodiazepines in pet models leads to increased degrees of stress (Document 1989), improved seizure sensibility (Rundfeldt et al. 1995), tremors, spontaneous convulsions, and bodyweight reduction (Suzuki et Bexarotene al. 1992). The researchers aren't united regarding the precise system that underlies the introduction of benzodiazepine dependence, desensitization of GABA/benzodiazepine conversation, and reactions that accompany benzodiazepine drawback. Several authors claim that some adjustments at the amount of the GABAA receptors and their working may partially donate to the introduction of benzodiazepine tolerance and dependence. Among they are adjustments in the structure of GABAA receptors induced by modifications in appearance of GABAA receptors, subunit mRNA and subunit proteins, decrease in GABAA receptor-mediated fast inhibitory synaptic transmitting (Chen et al. 1999), modifications in coupling between benzodiazepine site and GABA receptor-gated chloride stations (Brett and Pratt 1995; Gonsalves and Gallager 1985), or downregulation of benzodiazepine receptor binding in particular brain locations (i.e., cortex, hippocampus, and amygdala). Nevertheless, the protracted administration of diazepam almost certainly does not result in a reduction in GABAA receptor affinity (Fahey et al. 2001). Furthermore, it's been postulated that neuroadaptations in various other systems also needs to be taken under consideration. Glutamatergic neurotransmission and signaling reliant on nitric oxide (NO) make an undeniable contribution towards the advancement of benzodiazepine tolerance and the looks of the drawback symptoms. Both systems play crucial jobs in synaptic plasticity. Furthermore, a substantial hyperlink between GABAergic, glutamatergic and L-arginine:NO:cGMP pathways continues to be referred to (Allison and Pratt 2006; Segovia et al. 1994). Most importantly, after stimulation from the NMDA receptors-gated ion route, calcium mineral ions enter the cell and bind to calmodulin. Subsequently, Rabbit Polyclonal to BST2 the Ca2+-calmodulin complicated enables creation of NO from L-arginine consuming NOS (Garthwaite and Boulton 1995). Blockage from the NMDA receptor can be accompanied by decreased focus of NO and cGMP (Snyder 1992). It's been suggested how the compensatory systems (i.e., sensitization) in the glutamate signaling could be in charge of the appearance of benzodiazepine drawback symptoms (Stephens 1995). Initially, in response towards the improved GABAergic activity induced with a chronic administration of benzodiazepines, upregulation from the glutamatergic neurotransmission takes place. After benzodiazepine drawback, glutamatergic overactivity can be no more masked with the heightened inhibitory ramifications of the GABAergic program, which imbalance can lead to introduction of seizures, elevated muscle tissue tone, and anxiousness (Document and Fernandes 1994). Oddly enough, the NMDA receptors appear to be implicated in tolerance towards the sedative (Document and Fernandes 1994) and anticonvulsant (Koff et al. 1997) ramifications of benzodiazepines, aswell as the onset of drawback symptoms, whereas the -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors appear Bexarotene to be involved in the drawback process just (Steppuhn and Turski 1993). Relative to the outcomes of Suzuki et al. (1999), the metabotropic glutamate receptors ought to be mixed up in latter process aswell, since their antagonists can handle suppressing the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam drawback. Strong proof also helps the participation of NO signaling in the systems of medication tolerance and dependence (Babey et al. 1994; Wazlawik and Morato 2002), like the advancement of tolerance to diazepam-induced engine dysfunction (Talarek et Bexarotene al. 2008). The.
Soluble ligands have commonly been targeted by antibody therapeutics for cancers
Bessie Silva Acyltransferases June 4, 2017 Bexarotene, BSG	0 Comment
Soluble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases. with the corresponding distributions for complexes with mAb1 (Fig. 3and binding and phagocytosis of the BiS3Ab-IL-6 complex would translate into fast clearance, mice were injected Bexarotene with rhIL-6 alone or rhIL-6 incubated with the mAbs or BiS3Ab. rhIL-6 was cleared rapidly in mice, with only a small amount detectable 5 min after injection. As predicted for stoichiometric Ab-Ag complexes that bind FcRn, the serum half-life of rhIL-6 bound to parental mAbs was prolonged considerably (Fig. 6). In contrast, rapid clearance comparable with rhIL-6 alone was observed with the oligomeric complexes generated by BiS3Ab. Interestingly, a small amount of rhIL-6 persisted at the 1-h time point, consistent with the stoichiometric complexes detected for BiS3AbrhIL-6 as observed by AUC. FIGURE 6. BiS3Ab/IL6 complicated is certainly effectively cleared and (50). This common string is certainly a signaling element for FcR1, 3, and 4 in mice, with FcRI appearance decreased by 80% in knockout mice (51). Oddly enough, in these mice, there is no accumulation from the BiS3AbIL-6 complicated within the liver organ (Fig. 7, and (53). Further, whenever a BiSAb was implemented to cynomolgus monkeys, although complicated formation was noticed and bind and so are internalized into Bexarotene induced macrophages also. These data support a model where complicated development drives FcR binding and internalization (11) possess reported that bispecific antibodies inherently display speedy clearance in monkeys. Whether that is a general process remains to become motivated. They reported that BiSAbs aren't connected with Kupffer cells but, rather, connected with LSECs. Right here we survey that BiS3AbIL-6 complexes localize to Kupffer cells, obviously differentiating the BiS3AbIL-6 complicated clearance system from that reported by Datta-Mannan (11). Ongoing and upcoming function will elucidate the role of the BiSAb format in pharmacokinetic behavior and will be the subject of a separate report. However, the sum of the data presented here suggests that clearance of BiS3AbIL-6 complexes is usually driven by complex formation itself and not the molecular format of the BiSAb. Here we have offered a proof-of-concept study demonstrating that quick clearance of soluble antigens can be driven by forming immune complexes that contain three or more BiSAb molecules. For the proof of concept, we managed a 1:1 ratio; Bexarotene however, a therapeutic BiSAb designed to drive clearance would present a more complicated dynamic. To conceptualize complex sizes and clearance behaviors, it is useful to examine the limited cases of extra antigen on one hand and extra BiSAb around the other. With extra antigen, all binding sites on each BiSAb molecule would be occupied by single antigens. In this case, a stoichiometry of 1 1:4 BiSAb:Ag would be achieved, and negligible amounts of larger immune complex would form. The Bexarotene clearance of antigen bound to BiSAbs would be attenuated, but the majority of antigen would follow its normal metabolic path because it would not be bound to BiSAbs. As BiSAb concentration increased, larger complexes would form. Although it is not obvious at what ratio and concentration a maximum would occur, we have experimentally demonstrated that a 1:1 ratio drives very efficient complex formation under the conditions we tested. At extra BiSAb, antigen would become limiting, each antigen molecule would interact with a single BiSAb, and a stoichiometry of 1 1:1 BiSAb:Ag would be achieved. Under these circumstances, the BiSAb would efficiently prolong the half-life of the entire accessible pool of antigen. This thought experiment demonstrates the complexity of implementing the strategy proposed here experiments was purchased from R&D Systems (Minneapolis, MN). Binding to rhIL-6 Binding affinities of mAbs or BiS3Ab to rhIL-6 were determined with a BIAcore 3000 instrument (GE Healthcare Life BSG Sciences). 100 nm mAb1, mAb2, or BiS3Ab was immobilized on a CM5 chip, and 0.12 nm, 0.37 nm, 1.1 nm, or 3.3 nm rhIL-6 was applied to the chip. Concurrent binding of mAbs and BiSAb to rhIL-6 was exhibited by BIAcore 3000 instrument (GE Healthcare Life Sciences). 100 nm mAb1 or mAb2 was immobilized on the CM5 chip, and 100 nm rhIL-6 was put on the chip. Upon stabilization, the Bexarotene same antibody, the next antibody, or BiS3Ab (100 nm) was injected to determine concurrent binding..


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Pony Club Mounted Games. Photo by Leslie Wylie.
Turns out it's true: Once a Pony Clubber always a Pony Clubber. Joining Pony Club is like inserting a few specific neuroses straight into your DNA. Did you have a visceral reaction to our first post, Six Signs You're A Pony Club Graduate? Congratulations! You're in an elite club.
Status courtesy of Stephanie Jones .
Nancy Toby also kindly reminded us in the comments that Pony Club is no longer just for those Under 25! For more information on the Horsemasters Program, or to find a club near you, click here.


The HyArts Cultural District in downtown Hyannis supports and promotes arts and culture happenings in our downtown community. From artist shanties, to musical performances, the Kennedy Legacy Walking Trail to photo tours, you can enjoy an art-full day in downtown Hyannis year round. More information is available on line at www.hyartsdistrict.com and on facebook at hyartsdistrict.


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Felicity Aston, physicist and meteorologist, took months off from all human touch as she turned the 1st girl -- and in simple terms the 3rd individual in historical past – to ski around the complete continent of Antarctica on my own. She did it, too, with the straightforward gear of cross-country, with out the aids utilized by her prededecessors – Norwegian males – every one of whom hired both parasails or kites.
Aston's trip around the ice on the backside of the area requested of her the extremes when it comes to psychological and actual bravery, as she confronted the dangers of unseen cracks buried within the snow so huge they could engulf her and hypothermia because of brutalizing climate. She needed to deal, too, together with her emotional vulnerability in face of the consistent bombardment of hallucinations as a result of the gigantic sea of whiteness, the shortcoming of stimulation to her senses as she confronted what's tantamount to a kind of solitary confinement.
Like Cheryl Strayed's Wild, Felicity Aston's by myself in Antarctica turns into an inspirational saga of 1 woman's wade through worry and loneliness as she in truth confronts either the actual demanding situations of her event, in addition to her personal human vulnerabilities.
The world-famous adventurer finds a life of knowledge and classes realized from the planet's wildest placesLife within the outside teaches us beneficial classes. Encountering the wild forces us to devise and execute pursuits, face probability, push our "limits," and sharpen our instincts. yet our most crucial adventures do not continuously occur in nature's extremes.
The overseas bestselling sequence with over five million copies offered within the U. S. by myself! while Horace travels to the unique land of Nihon- Ja, it's not lengthy sooner than he reveals himself pulled right into a conflict that's not his - yet one he is familiar with in his center he needs to salary. A country teeters at the fringe of chaos whilst the Nihon-Ja emperor, a defender of the typical guy, is forcibly overthrown, and in simple terms Horace, Will, and his Araluen partners can fix the emperor to the throne.
With the Lapps within the excessive Mountains is an entrancing actual account, a vintage of commute literature, and a piece that merits wider attractiveness as an early contribution to ethnographic writing. released in 1913 and to be had right here in its first English translation, it's the narrative of Emilie Demant Hatt's nine-month remain within the tent of a Sami relatives in northern Sweden in 1907–8 and her participation in a dramatic reindeer migration over snow-packed mountains to Norway with one other Sami group in 1908.
A thousand White ladies is the tale of may well Dodd and a colourful meeting of pioneer ladies who, less than the auspices of the U. S. executive, trip to the western prairies in 1875 to intermarry one of the Cheyenne Indians. The covert and debatable "Brides for Indians" application, introduced by way of the management of Ulysses S.
Forming a circle 2 hundred kilometres throughout, the final measure of range round the Pole is a strict no-poo area. All human waste needs to be deposited in precise luggage and over excited. I were making deposits into ziplock luggage for the previous week and had them appropriately stowed, frozen, within the backside of my sledges less than the sledge baggage. in the boundary of the South Pole station it's also a no-pee quarter. I'd been instructed to hold a pee-bottle with me as I approached and to deposit the contents later at a suitable facility in the station compound. even if, because the rectangular received nearer it happened to me that I didn't are looking to need to pull down my trousers to pee close by of employees on the base, bottle or no. I waited till i used to be as shut as I dared earlier than preventing for what I was hoping will be my final bathroom toilet holiday. relocating off back, the station was once so shut that i may see solar reflecting from its home windows and a flash of sunshine that i made a decision has to be a digicam flash. i spotted the cloud that were in the back of me slowly creep over the solar, making me shiver and virtually immediately knocking down the distinction. The air among me and the South Pole grew hazy, in order that the perimeters of every thing seemed watery and washed out, like summary watercolours. The station was once unusually quiet. I hadn't obvious a unmarried motor vehicle. i finished lifeless in horror. i used to be shut sufficient to determine that this wasn't the Amundsen–Scott station in any respect. Tears of frustration rose immediately and that i felt a feeling of desperation extra vengeful than in the course of my first actual few hours on my own. It was once like i used to be correct again at the Leverett Glacier. because the cloud thickened round me, decreasing the visibility with the certain decision of a dimming swap, I observed that my darkish rectangular used to be now not the South Pole, it wasn't even a development. It used to be of the massive gasoline bladders dragged through the SPOT traverse. Their rubbery dermis ribbed with bolstered seams had glinted within the sunlight like steel and within the empty panorama they'd appeared a lot higher, than they have been actually. that they had been deserted within the snow by way of the convoy, nonetheless bloated with gas, most likely for garage until eventually they have been wanted. Like a vacationer pictured keeping up significant Ben or squishing the Eiffel Tower with their thumb, it used to be a trick of scale and viewpoint. a foul navigator forces their atmosphere to slot a map so that it will turn out they're going within the correct course. I had missed the entire indicators and grew to become my wish into fact even supposing what I observed didn't healthy what I knew. the inability of the satellite tv for pc domes, the shortcoming of outlying constructions, the inability of circulate. Antarctica had fooled me. as though to check my temper, the elements closed in, stealthy and silent, till i used to be enclosed in a personal, melancholic international of gray. My mind wearily digested this newest blow because the wind rose from not anything right into a gale in what felt like a couple of minutes. I paused to strength the zip of my jacket correct as much as the head of my collar in order that the fur of my hood tightly enclosed my face and provided a few security. via my goggles i'll see a fur rimmed oval, a limited porthole looking onto a nacreous mass of transferring mild and snow-choked air.


Construction models for forecasting this behaviour with using existing tools and comparing the obtained results with application of different methods of artificial intelligence (bayesian networks, neural networks, decision-making tree).
Abstract: A new procedure for combined validation of learning models – developed for specifically uncertain data – is briefly described; it relies on a combination of resubstitution with the modified learn-and-test paradigm, called by us the queue validation. In the initial experiment the elaborated procedure was checked on doubtful (presumably distorted by creative accounting) data, related to small and medium enterprises of the Podkarpackie-region in Poland. Validated in the research learning models were completed in the form of decision trees and sets of production rules. Correctness of both types of models (trees and rules) was estimated basing on the error rate of classification. It was found that false-positive classification errors were significantly larger than false-negative ones; the difference discovered by validation procedure can be probably used as a hint of fraud in the evaluated data.
Abstract: Our paper presents the concept behind a new methodology of predicting the future condition (i.e. over-all state) of small and medium enterprises, relied on results of a specific data mining procedure. The developed procedure is based on the controlled improvement of the source data set (describing the investigated objects) with the use of an ensemble of artificial neural networks, EANN. Then, in the next step of the procedure, various machine learning algorithms are applied to generate models that figure out inherent properties of the investigated objects. The reliability of the prediction, confirmed in a very exhaustive tests conducted on data from the span of 8 years, was close to 80% of correctness.
Summary: The structure of a belief network model for predicting the economic situation of small and medium enterprises in the Lubelskie and Podkarpackie provinces is discussed. The direction of further scientific research in order to improve performance of a belief network model is additionally presented.
Summary: Results of predicting an economic and financial situation of small and medium size enterprises from Lubelskie and Podkarpackie regions are presented. As opposed to other research in this field, the micro-macro (mezzo-) modeling concept was used. The results of prediction using neural perceptions and two types of ensembles of artificial neural networks were compared. Some conclusions and directions of further research aiming at improving quality and extending the functionalism of enterprises being investigated are dealt with.


The Invisalign plastic aligners are becoming widely appreciated and used for its subtlety in comparison to metal braces. It is not easily noticed and can be invisible to people sitting close or next to you. Most times, only the user is aware of its attachment, although, some discomfort can be felt with this aligner when the set is brand new. Using Invisaligncan be made pleasurable by applying the following tricks compiled by Oracare dental clinic briefly outlined below.
It is not advisable to leave your trays on for too long without brushing and rinsing the mouth because it can affect the overall taste of your mouth. To avoid this, ensure you soak your trays in diluted mouthwash such as the Biotene Dry mouth Rinse. Mix it with water in equal proportion and leave your trays in there for three to five minutes. This is capable of leaving you with fresh breath always.
The act of constantly dipping your hands into your mouth to take out your trays can result in the introduction of pathogens into your mouth. Also, it can do great damages to your fingernails as a lady. The appropriate way to remove trays is to use an Invisalign tray removal tool such as the Outie which is effective for removing delicate brand-new trays. You need to be more careful because of the invisible nature of trays, so you don't damage it, leaving you with no option than to buy a new one.
This trick is not useful if you feel the edges of your tray are smooth and you are comfortable with it. In cases where your tongue or gums feel scratched, purchase a fine grit nail buffer to smoothen out the edges of your plastic corrective dental wear.This option is better than the metallic file due to its tenderness.
Don't make the mistake of putting in your Invisalign trays immediately after a meal, because the food debris left hanging in between your teeth can distort the shape of your tray and can cause discomfort. Dentist recommends you wear Invisalign for 22hours in a day but ensures you wash your mouth properly after every meal before putting them back in to avoid bad breath and poor teeth alignment.


text:
title: "Storm Guide by savannahnow.com"
excerpt: "For the 2013 hurricane season, I built a native iOS and Android app with an accompanying HTML5 "
tags:
  - "APP-DEVELOPMENT"
date: 2013-06-14
permalink: /portfolio/storm-savannah-now/
header:
  teaser: /portfolio/storm.jpg
sidebar:
  - title: "Role"
    image: /images/portfolio/storm.jpg
    image_alt: "logo"
    text: "Designer, Front-End Developer"
  - title: "Responsibilities"
    text: "Reuters try PR stupid commenters should isn't a business model"
gallery:
  - url: /images/portfolio/storm1.jpg
    image_path: /images/portfolio/storm1.jpg
    alt: storm app
  - url: /images/portfolio/storm2.jpg
    image_path: /images/portfolio/storm2.jpg
    alt: storm app
  - url: /images/portfolio/storm3.jpg
    image_path: /images/portfolio/storm3.jpg
    alt: storm app
  - url: /images/portfolio/storm4.jpg
    image_path: /images/portfolio/storm4.jpg
    alt: storm app
---

For the 2013 hurricane season, I built a native iOS and Android app with an accompanying HTML5 mobile site to tie in with the print edition of our annual "Hurricane Guide" sponsored by Georgia Power.

{% include gallery caption="" %}

Designed, developed and built by Carl V. Lewis of Savannah Morning News Digital Network, with sponsorship from Georgia Power

# App Details

Your go-to source for breaking severe weather updates, interactive storm-tracking and directions to nearby evacuation shelters in Coastal Georgia, the South Carolina Lowcountry and beyond. Powered by the multimedia reporting staff of savannahnow.com and sponsored by Georgia Power, this app is a must-have tool for anyone in the region seeking safety during a natural disaster –– or just those who want to be prepared should the unfortunate time arrive.

OTHER FEATURES INCLUDE
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- Geolocated, interactive radar and storm-tracker, specifically tailored to your current location.
- Real-time updates on current power outages provided by Georgia Power, and the ability to report outages from within the app.
- Evacuation route maps, city surge levels and guided directions from your current location to the nearest inland safety zone or shelter.
- Ability to upload photos, check-in and post status updates to nearby evacuees, and log in easily and securely via your Facebook or Twitter account.
- Share current weather conditions and photos from where you are with other Storm Guide users across smartphones and even the mobile web by commenting and 'liking' within the app's built in social network called "Eye-Reports."
- Explore photos and videos taken by SMN multimedia reporters, by other app users and by nearby social media users.
- Access to exclusive multimedia content from local and state emergency management officials on hurricane preparedness, including topics such as preparing your pets for evacuation, creating a disaster supply kit and building a storm shelter.
- Accesss to live weather cameras displaying current conditions on Tybee Island, the Savannah River and more.
- Stream the National Oceanic and Atmospheric Administration's official severe weather radio broadcasts from directly within the app.
- Get help locating a missing loved one directly within the app through the American Red Cross' official "Safe and Well" disaster preparedness program.

redpajama_set_name: RedPajamaGithub


There are six screw holes on the Multi-Mount Kit that provide higher and lower VESA100 positions to mount the 1503 monitor on a wall mount or arm, which makes the layout adjustable and space-efficient.
A bracing plate inside the Multi Mount Kit can be screwed on for providing three viewing angles: 30°, 40°, and 75°. A lower angle will be perfect for touch and writing requirements.
The 1/4" screw hole on the bottom of Multi-Mount Kit allows photographers to install the 1503 monitor on a tripod by securing it to the camera cradle head.
On-Lap 1503 Proprietary kit includes 4 VESA 100 screw holes and one 1/4" screw hole. It can be applied to a VESA 100 arm/mount or tripod. When using the 1503 touch monitor on a surface, it can be set as a monitor stand to support a 30°, 40°, or 75° viewing angle.
The Multi Mount Kit for the 1503 is designed with 6 VESA 100 screw holes.
You can choose to screw higher or lower VESA 100 positions, or install an IntelⓇ NUC with a low-position stand as well.
The 1503 Multi Mount Kits provides flexible and useful VESA and stand solutions for your space planning.
Mini PC turns into All-in-One.
An Mobile Way for Maker.


Filter by Request Status (optional)Successful. Awaiting response. Partially successful. Awaiting internal review. Information not held.
Response by Guy's and St Thomas' NHS Foundation Trust to M Potter on 17 August 2018 .
Response by Portland Medical Practice, Kilmarnock to M Potter on 14 June 2018 .
Response by Eglinton Family Practice, Irvine to M Potter on 13 June 2018 .
Response by Stewarton Medical Practice, Stewarton to M Potter on 12 June 2018 .
Response by Galston Medical Practice, Galston to M Potter on 9 June 2018 .
Response by Dundonald Medical Practice, Dundonald to M Potter on 8 June 2018 .
Follow up sent to Glencairn Medical Practice, Crosshouse by M Potter on 6 June 2018 .
Follow up sent to NHS National Services Scotland by M Potter on 6 June 2018 .
Follow up sent to Largs Medical Group, Largs by M Potter on 6 June 2018 .
Response by Arran Medical Group, Arran to M Potter on 6 June 2018 .
I am currently out of the office until Wednesday 13th June 2018 and will deal with your email on my return.
Follow up sent to Kilwinning Medical Practice, Kilwinning by M Potter on 6 June 2018 .
Follow up sent to Kilbirnie Medical Practice, Kilbirnie by M Potter on 6 June 2018 .
Follow up sent to Marple Medical Practice, Greater Manchester by M Potter on 6 June 2018 .
Request to Dr Pugh & Partners, Kilmarnock by M Potter. Annotated by M Potter on 25 May 2018 .
Follow up sent to Loudoun Medical Practice, Darvel by M Potter on 25 May 2018 .
Follow up sent to West Kilbride Group Practice, West Kilbride by M Potter on 25 May 2018 .
Follow up sent to The Fullarton Medical Practice, Ayr by M Potter on 22 May 2018 .
Follow up sent to Beith Health Centre GP Practice, Beith by M Potter on 22 May 2018 .
Follow up sent to The Surgery, Ayr by M Potter on 22 May 2018 .
Follow up sent to Station Road Medical Practice , Prestwick by M Potter on 22 May 2018 .
Follow up sent to Maybole Medical Practice, Maybole by M Potter on 22 May 2018 .
Follow up sent to Tam's Brig Surgery, Ayr by M Potter on 22 May 2018 .
Follow up sent to Bourtreehill Medical Practice, Irvine by M Potter on 22 May 2018 .
Follow up sent to Dr McCulloch & Partners, Girvan by M Potter on 22 May 2018 .
Follow up sent to Riverside Medical Practice, Patna by M Potter on 22 May 2018 .
Request to Adshall Road Medical Practice, Greater Manchester by M Potter. Annotated by M Potter on 1 August 2016 .
Request to Milan Street Surgery, Leeds by M Potter. Annotated by M Potter on 25 July 2016 .
Request to NHS Health Scotland by william rennie. Annotated by M Potter on 10 July 2016 .


It has been a few months since I joined the Foreign Service, time for an update!
A-100 is six weeks long, and I had 97 classmates. We had classes in management, State organization, interdepartmental relationships, all the good (sometimes sleepy) stuff you'd expect from a federal agency.
The highlight of A-100, therefore, was what is famously known as Flag Day, where we were given our assignments. It was a day fraught with tension and excitement - a flag was projected on a screen, a name was called, and we were given a flag of our assigned country by Ambassador Ken Merten. Happily my name was called towards the beginning so I could enjoy celebrating with the rest of my classmates as they were given their posts.
I was assigned one of our top bids - Kingston, Jamaica. We asked for Jamaica primarily because The Historian was offered a new job in DC right after my own offer came in. After much discussion, we agreed that for my first tour, he would take the new job while I did my first tour. Kingston was therefore very appealing for its proximity to DC and because it is an English-speaking post. This means I will have to have language training after this tour, and that will give Chris nearly three years in his job before he joins me for my next post.
After A-100 concluded, I had a few weeks of specialized training and arrived in Jamaica in late July. My job here is as a Consular Officer, and I currently interview 100+ applicants/day who are applying for non-immigrant visas to come to the United States. This is usually tourist visas, but could also be business, student, or exchange visitors. I've done around 3500 interviews so far.
Jamaica is an interesting post - it is a critical crime threat post, and household goods are very expensive (a new ironing board priced out at $65) This will put me in the first tranche for bidding on my second tour. Jamaica also has a unique relationship with the US - its proximity means that flights are cheap, and everyone has a family member (or several) who live in the US. This means that we have an extraordinarily high number of visa applicants - it is not implausible for a poultry farmer who lives on a few hundred dollars a month would make a trip to the US to see family or to go shopping, something that would be out of reach for an equivalent income in nearly every other country.
My housing is nice, and the views are amazing. There is one beach we can get to from Kingston, by hiring a fishing boat to ferry us to an uninhabited island. Otherwise the more famous beach cities are 2.5 hours (Ocho Rios) and 4.5 hours (Montego Bay) drive. I'm looking forward to exploring some of the less touristy beaches. The embassy also organizes various excursions, including to release endangered sea turtles and an excursion to the Appleton rum distillery. Household help is also very affordable, and I have an amazing helper who comes two days a week who cleans, cooks great Jamaican food, and does light shopping.
If you are a Facebook friend, you will also know that we had a brush with Hurricane Matthew over the weekend. One of the best things about the State Dept is that it really is a community (there are fewer diplomats than there are military band members in this country). It was amazing to watch how everyone pulled together to either support those who evacuated and to ensure the safety of those of us who stayed.
What's this all about then?
South Dakota girl who got lost in Los Angeles for a while and then escaped to Seattle. Currently serving in the U.S. Foreign Service in Jamaica. Opinions are my own.
Following the Sky Road by http://hihankara.blogspot.com/ is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.


We are an Australian-Danish family company founded in 2010 while still living in Australia. Allan is a qualified chef and organic farmer and is deeply interested in where food comes from and how it is produced. We always had a passion for supporting sustainable organic and fairtrade food sources and a great love for chocolate. Our first company back in Australia we named 'Andersen Cacao Creations' to include our Danish heritage. In 2016 we returned to Denmark and brought with us the passion and experience of building up a business that grew solely on word of mouth into a family company incorporating a team of distributors, shops and creative chefs and catering companies. To mark a new beginning in Denmark, we renamed our business to'Pods of Beans' . We are happy to work in many creative ways with our Danish clientele to help them adding that extra conscious touch to their own businesses.
We have carefully selected the best organic ingredients, namely cocoa from organic 'raw' Criollo cocoa beans, which are recognized for their fine taste. This cocoa originates from the Peruvian Amazon and is supporting a co-op of organic small farmers. These beans allow us to produce natural "raw" chocolate products of absolute highest quality (75% cocoa): Chocolate, chocolate bark (thin chocolate slices), chocolate spread, chocolate drink, etc.
We pride ourselves to create exquisite products that maintain their high nutritional value, all still carefully produced by hand in small portions and at low temperatures and, of course, in Denmark now. They are 100% vegan, gluten and lactose free.


Welcome to the local directory of Crewe Weddings on Crewe.co.uk. It includes ratings, reviews, contact details and photos of weddings in Crewe and the local area including Congleton, Nantwich, Northwich, SandbachAnd Tarporley. Is your business missing from the Crewe business directory? Advertise it now!


text:
Jordan Love showed he isn't ready and that strengthens Aaron Rodgers' grip on the Packers
·Columnist
November 7, 2021, 9:57 p.m. ·4 min read
If you want to know why the Green Bay Packers said little to nothing as Aaron Rodgers passive-aggressively complained about the front office's decisions, mocked coaching calls, skipped minicamps, tried out to be a game show host, intimated he might leave the franchise after the season and refused to get vaccinated for COVID-19 – which put him in NFL protocol crosshairs – all you needed to do was tune into Sunday's 13-7 loss to Kansas City.
The game also explains why Rodgers felt emboldened enough to act that way.
The Packers have no chance but to bend their knee to Rodgers. It's either that or take a step back from Super Bowl contention.
And Rodgers knows it because while Sunday was the public's first glimpse of his supposed eventual replacement — second-year quarterback Jordan Love — Rodgers has had a front-row seat for a year and a half to scout him.
Here's guessing Love's performance in K.C. wasn't a surprise to No. 12, who was forced to miss the game after testing positive for COVID.
"Aaron talked to me before and said, 'Just go out there and ball out,'" said Love, who finished 19 of 34 for 190 yards, a touchdown and an interception. "He was excited to watch me."
No doubt he was.
QB Jordan Love lost in his first start with the Packers. (Scott Winters/Icon Sportswire via Getty Images)
Perhaps Love will develop into a quality NFL quarterback. There's no need to classify him as a forever bust after just one start.
That said, he isn't very good right now and he showed little Sunday to suggest he is close to being a viable starter, let alone one on a team with Super Bowl aspirations.
Love didn't deliver much of a stat line, but his play was even less inspiring. While he avoided a ton of crushing mistakes, and showed plenty of resilience, he also made few plays of note.
"Really disappointed," Love said. "Obviously you never know when the opportunity is going to come ... not being able to go win that game. ...I wasn't able to execute. It's very disappointing."
There was one good second-half drive, but other than that, the offense stalled. The Packers were shut out until 5:00 remaining in the fourth, when the game was mostly decided. In the first half, he looked completely overwhelmed, especially when facing a blitz. It wasn't until late in the second quarter that he ever threw a pass longer than 10 yards.
Just about every part of his game was shaky.
Considering he had 18 months to learn the Packers' offense and all week to prepare as the starter with Rodgers out with COVID, it was fair to expect better.
"Offensively when you score seven points, that just isn't going to get it done," said head coach Matt LaFleur, who heaped praise on Love afterward and placed blame for the loss on himself for not having a better game plan to help a young quarterback.
Also not a help: special teams. Still, the Chiefs' offense was a mess and the defense, per LaFleur, delivered a "championship-level performance."
LaFleur admirably tried to spare his QB from criticism, even refusing to conclude that quarterback play was a difference. "Oh, who knows, guys," LaFleur said.
Eh, most Packers fans know. If Rodgers is the quarterback, Green Bay almost certainly wins and moves to 8-1. Instead it is 7-2 and hoping Rodgers is back against Seattle next week.
One loss won't crush the Packers — the NFC North is terrible — but if Love can't beat a Kansas City team playing this poorly, then a deep playoff run seems almost impossible. And in Green Bay, it's Super Bowl or bust. The roster is too good for it to be anything less.
That means Rodgers' position is further strengthened. The entire concept that Green Bay traded a fourth-round draft pick to move up and select Love 26th overall in 2020, rather than adding a player who can get on the field the past season and a half and perhaps push the Packers to a title, seems even more baffling.
Rodgers opposed the move the moment it was made, starting 18 months of drama. Now that the world, let alone the Packers, have seen that the Utah State product still isn't ready, Rodgers looks even smarter.
Why waste a first-round pick and start a feud with your franchise quarterback for a guy who still isn't ready?
The Packers' only chance at winning much this year — or next — is with Aaron Rodgers as their starter. No matter what he does, what he says, or what vaccine he doesn't get, the team has no other option but to try to placate him.
If you thought things were interesting before …
Kamaru Usman drops Colby Covington twice, retains title by unanimous decision
Yahoo Sports·3 min read
Canelo Alvarez finishes Caleb Plant for undisputed super middleweight title
College football Week 10 Winners and Losers: Dan Mullen, Florida hit rock bottom with blowout loss to South Carolina
Yahoo Sports·14 min read
College football takeaways: This season's about survival, not style points
N.B.'s plan to get more hospital patients into long-term care long overdue, say operators
Special care home operators say a plan by the province to move hospital patients into long-term care facilities faster is a welcome move, but long overdue. The government announced recently that it would work with long-term care homes to create emergency care beds for hospital patients currently waiting to be placed in a home. The province says it's part of efforts to alleviate pressure on the health-care system at a time when New Brunswick is seeing a record level of hospitalizations due to COV
Accessibility of Pfizer pill in Canada raises ethical questions
Recently approved antiviral pill 'paxlovid' has been dubbed a game-changer. Despite this, concerns persist about the accessibility of the pill and who should be getting it first. Bioethicist Kerry Bowman shares insight on the issue
Treacherous travel, road closures as dangerous storm moves through Prairies
Drivers are urged to avoid any non-essential travel across the eastern Prairies on Tuesday as snow and powerful winds make for near zero visibility.
Military dealing with more than 10,000 unfilled positions amid growing pressures
OTTAWA — New figures show the Canadian Armed Forces are struggling with a growing shortage of personnel even as the military faces more and more demands at home and abroad. While the military is supposed to have just over 100,000 troops at full strength, new Defence Department figures show it was short about 12,000 regular force troops and reservists at the end of November. The shortfall is worse than at the end of 2020, when military was short about 7,000 troops as the onset of the pandemic for
Town of Inuvik closes offices, stops short of a lockdown as COVID-19 cases rise
The Town of Inuvik is closing its offices as of 5 p.m. Wednesday, but councillors stopped short of declaring a voluntary lockdown in light of the Office of the Chief Public Health Officer's (OCPHO) latest announcement about cases in the community. In a press release Jan. 18, the OCPHO said there is community spread in Inuvik, and they are currently seeing a "significant increase" in cases in the Beaufort-Delta community of about 3,300 people. The same is true of Fort Smith, in the South Slave. I
OTTAWA — Government House leader Mark Holland is urging the Conservatives to reconsider their rejection of a compromise proposal that would allow MPs to finally see unredacted documents related to the firing of two scientists at Canada's highest-security laboratory. In a letter Tuesday to his Conservative counterpart, Gerard Deltell, Holland reiterates his proposal to allow a special all-party, security-cleared committee to review all the documents, aided by three former senior judges who would


1. Standard pricing and add-ons can be seen on the "investment" page. I put it all out there because I've got nothing to hide and I don't want to waste your time. The only things I can't list are things we'd have to customize. Make sure you look that over and have a good idea of where my pricing starts. I'd be happy to discuss things further, especially if you want to customize something beyond what is standard, but just make sure you review that first so we're on the same page!
Tell me ALL the things. Ready, set, GO!
What's your budget for Photography? Just ball park it. Everyone's got a budget so don't be shy!
So tell me about YOU!!! How'd you guys meet? What's the story?
So tell me honestly, what can I do for YOU? What are you looking for in a photographer?
What about my work stood out to you? Is there a particular image or blog post that you liked the most?
How ready are you to book a photographer?


text:
B.C. and the Feds announce $469 million in highway improvement funding
Highway 1 through Kicking Horse Canyon will be realigned and expanded to four lanes with median barriers and widened shoulders.
Kicking Horse Canyon
Federal Minister of Infrastructure and Communities Amarjeet Sohi, speaking in Kamloops. (source: BC Government)
Speaking in Kamloops, Amarjeet Sohi, Minister of Infrastructure and Communities, and B.C. Transportation and Infrastructure Minister Todd Stone, have announced $469.4 million in funding to expand and upgrade two major sections of the TransCanada Highway.
Out of this amount, the Kicking Horse Canyon project accounts for nearly $450 million, while the Donald to Forde Station section of highway accounts for over $19.4 million.
Highway 1 through Kicking Horse Canyon will be realigned and expanded to four lanes with median barriers and widened shoulders. Improving this section will also require a combination of bridges, retaining walls, rock catchment ditches and other measures to reduce rock fall hazards.
Work on the second section of Highway 1 approximately 20 kilometres west of Golden, from Donald to Forde Station Road, will involve expanding the highway to four lanes and improving access at the weigh scale.
"This major transportation infrastructure project in British Columbia will benefit residents, businesses, and tourists, while fostering long-term prosperity across the region. We will continue working in close collaboration with British Columbia to ensure we make smart infrastructure investments that help build the Canada of tomorrow," said Sohi, in a release.
For work through Kicking Horse Canyon, the Government of Canada will provide up to $215,198,500 through the New Building Canada Fund–National Infrastructure Component. The Government of British Columbia will match the federal contribution and provide $19,603,000 to cover additional related project expenses.
For the work on Donald to Forde Station, the Government of Canada will provide up to $7,270,000, through the Provincial-Territorial Infrastructure Component–National and Regional Projects. The Government of British Columbia will match the federal contribution and provide $4,860,000 to cover additional related project expenses.
The total project costs are estimated at over $469 million, for which the Government of British Columbia is providing up to $247 million, and the Government of Canada is providing up to $222 million.
New Highway 104 in Nova Scotia receives funding
Saskatchewan receives another $38.6 million in government infrastructure funding
B.C. issues tender for $36 million Mountain Highway Interchange
New road funding for Nova Scotia
IMAX movie 'Dream Big' inspires next generation of engineers
Port Mann water supply tunnel delivering drinking water south of the Fraser River


text:
It's All in the Name
It's All in the Name: Updated FDA Guidance on Nonproprietary Naming of Biologic Products
Jeffrey A. Wolfson , Evert Uy Tu
In January 2017, the FDA published guidance that adopted a naming convention that attaches a distinguishing suffix to the proper names1 of both originator and biosimilar biological products. The guidance also noted that the FDA was considering retrospectively changing the names of biological products already on the market to add distinguishing suffixes.
On March 7, 2019, the FDA published draft guidance that updates the January 2017 guidance document. First, the FDA determined that the proper names of biological products that have already been licensed or approved under the Public Health Service Act (PHS Act) and that do not include an FDA-designated suffix in their proper names need not be revised. Similarly, the FDA indicated that it does not intend to apply the naming convention to transition biological products, which are biological products that are the subject of an approved application under section 505 of the Federal Food, Drug, and Cosmetic Act (FD&C Act) as of March 23, 2020, and will be deemed to be a biologics license application (BLA) under section 351 of the PHS Act on March 23, 2020.
Second, the FDA noted that it is reconsidering whether vaccines, which are currently within the scope of FDA's biologic naming framework, should be subject to the naming convention. The FDA mentioned that it will determine whether currently available identification systems are sufficiently robust to meet the FDA's pharmacovigilance goals.
Finally, for interchangeable biosimilar products to be approved in the future, the FDA intends to designate a proper name that is a combination of the core name2, along with a distinguishing suffix that is devoid of meaning and composed of four lowercase letters. The FDA determined that a unique suffix would help determine which biological product is dispensed to patients when other means to track this information are not readily accessible or available. Use of the suffix will also avoid the need for changes to the nonproprietary name of a biological product that is first approved as a biosimilar product, and then later approved as an interchangeable product.
Ultimately, the unique suffixes in the FDA's proposed naming convention are a way for the FDA to better monitor adverse events and link them to a specific biologic product and manufacturer for patient safety. Comments and suggestions to the draft guidance should be submitted to the FDA by May 7, 2019.
1 "Proper Name" means the nonproprietary name designated by FDA in the license for a biological product licensed under the PHS Act (see 21 C.F.R. § 600.3(k)). The proper name generally reflects certain scientific characteristics of the product, such as chemical structure and pharmacological properties. This name is different from a proprietary name, which is generally a registered trademark.
2 "Core Name" means the component shared among an originator biological product and any related biological product, biosimilar product, or interchangeable product as part of the proper names of those products.
Jeffrey A. Wolfson
T +1 202.654.4565
Evert Uy Tu
FDA Regulatory and Compliance
Hatch-Waxman/ANDA


text:
Submit Family
Elleniká
Srpsk
Molly Rowell
Name Molly Rowell
Born 10 Sep 1782 Hopkinton, Hillsborough, New Hampshire, United States
Person ID I3469 Muse-Nagy
Father Abraham Rowell, b. 3 Dec 1743, South Hampton, Rockingham, New Hampshire, United States , d. Bef 24 Feb 1815, Hillsborough County, New Hampshire, United States (Age 71 years)
Mother Elizabeth Eastman, d. Aft 2 Apr 1816
Married Apr 1764
Family William Whitcher Sargent, b. 24 Jan 1776, New Chester, Grafton, New Hampshire, United States , d. 7 May 1846 (Age 70 years)
Married Bef 7 Dec 1813
1. Caleb Sargent, b. 18 Apr 1801, Hill, Merrimack, New Hampshire, United States , d. 27 May 1801, Hill, Merrimack, New Hampshire, United States (Age 0 years)
2. Caleb Sargent, b. 23 Apr 1802, Hill, Merrimack, New Hampshire, United States
3. Hosea Sargent, b. 8 Mar 1804, Hill, Merrimack, New Hampshire, United States
4. Anna Whittier Sargent, b. 12 Feb 1806, Hill, Merrimack, New Hampshire, United States
5. Cyrus Smith Sargent, b. 19 Feb 1808, Hill, Merrimack, New Hampshire, United States
6. Sibyl R Sargent, b. 29 Mar 1809, Hill, Merrimack, New Hampshire, United States
7. Deborah Smith Sargent, b. 30 Jul 1811, Hill, Merrimack, New Hampshire, United States
8. Sylvester H Sargent, b. 6 Oct 1813, Hill, Merrimack, New Hampshire, United States
9. Sarah Wells Sargent, b. 7 Jan 1816, Hill, Merrimack, New Hampshire, United States
Last Modified 17 Oct 2019
1782 Birth for Molley Rowell
Birth date: 10 September 1782
Birth place: Hopkinton, Hillsborough, New Hampshire
Father's name: Abraham Rowell
Mother's name: Elisabeth
Ancestry.com, New Hampshire, Birth Index, 1659-1900
1800 Marriage for William Witcher Sargent and Polly Rowel
30 January 1800, Henniker, New Hampshire
Groom: William Witcher Sargent
Bride: Polly Rowel
Residence of Groom: New Chester
Residence of Bride: Hopkinton
Ancestry.com, New Hampshire, Marriage and Divorce Records, 1659-1947
1813 Will for Abraham Rowell
Hillsborough County, New Hampshire
Will dated: 7 December 1813
Will proved: 24 February 1815
Listed in the will:
Wife: Elisabeth
Sons: Thomas, Jacob, Abraham, Isaac, Jonathan, Moses, Samuel
Daughters: Sary Wells, Molly Sargent, Nancy Gove, Betsy Kindrick (deceased), Hannah Colby
Ancestry.com, New Hampshire, Wills and Probate Records, 1643-1982, Hillsborough, New Hampshire, p. 382-383
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OPINION: Confronting the new carbon bomb in Southeast Asia
by Gerry Arances | @CEEDphilippines
Monday, 20 June 2022 07:41 GMT
FILE PHOTO: A worker drives an open truck full of coal before unloading it inside a warehouse in Tondo city, metro Manila January 11, 2016. REUTERS/Romeo Ranoco
Southeast Asia has chosen its path away from coal but that was not the end of the story
Gerry Arances is founder and executive director of Center for Energy, Ecology and Development (CEED) in the Philippines
Five years ago, I wrote about the crossroads that the Philippines and Southeast Asia were confronting as the last battleground of coal.
Back then Southeast Asian nations – specifically Indonesia, Vietnam, the Philippines, Myanmar, Malaysia, and Cambodia – were among the top 30 countries with the biggest coal expansion plans. With a total planned capacity of 125,307 MW, they accounted for nearly 15% of the total coal power in the global pipeline.
Southeast Asia chose its path away from coal. Coal pipeline fleets were defeated in the Philippines, while government policies in South Korea and other Asian countries and major bank policies and massive energy finances diverted away from coal financing. The hope to achieve the 1.5°C global goal became more realistic.
Unfortunately for the country and the region, that was not the end of the story.
Coal was being displaced, only for another fossil fuel to take its place – fossil gas. A massive 138 GW of new gas-fired power plants and 118 liquified natural gas terminals are being proposed or already being built in the region, amounting to a massive US$33.4 billion in investments, which surpasses even that of China's gas pipeline in 2022.
This trend is led by the same countries that have embarked on a coal avalanche in the region five years ago, and the very same countries that have vast renewable energy potentials – Vietnam, Indonesia, Philippines, and Thailand. The Philippines alone boasts more than 10 times of renewable energy potential compared to its total installed power capacity at present.
Although couched in the language of transition, this clearly is not a case of fossil gas being a bridge fuel, rather it is another path away from renewable energy. This is a major challenge for the climate vulnerable region given the very small window we collectively have in avoiding runaway climate change in this decade.
It is for this reason that the study, Financing a Fossil Future: Tracing the Money Pipeline of Fossil Gas in Southeast Asia by the Center for Energy, Ecology, and Development comes at a perfect time.
From this report, which maps the drivers and financial backers of fossil gas and LNG developments in Southeast Asia today, we know that Philippine conglomerate San Miguel Corporation Global Power Corporation's (SMC Global Power) accounts for the largest share of new fossil gas power in the region, with a total of 14.1 GW in the pipeline - a capacity bigger than any other developer's.
Financial institutions continue to underwrite these projects despite their pledge to decarbonize. In fact, 15 of these institutions which joined the Net-Zero Banking Alliance, Net-Zero Asset Owners Alliance, or Net Zero Asset Managers initiative, still funded US$1.5 billion in loans and bonds for these projects.
International financial institutions and government-backed financial institutions also funded these fossil gas projects, such as the Asian Development Bank, South Korea's Korea Development Bank and Export-Import Bank of Korea, Germany's KfW, Thailand's Government Savings Bank and Export-Import Bank of Thailand, Norway's DNB Bank, and Japan's Japan Bank for International Cooperation and Nippon Export and Investment Insurance.
This financing makes the SMC Global Power's proposals, along with those of other companies in other countries in the region, feasible despite their threat to the environment.
SMC Global Power claims that fossil gas is our best bet for a shift to clean and safe energy, but this could not be farther from the truth. In the Philippines, SMC Global Power's projects threaten the Verde Island Passage, the center of biodiversity in the Philippines, as large fossil gas carriers ferry their load to and from the terminals to be situated in the area.
While we regret facing this challenge in the region instead of leapfrogging towards 100% renewable energy systems, we are still in a better situation compared to 8 to10 years ago. Renewable energy technologies are far more competitive now, if not cheaper, compared to coal and fossil gas.
There are also more policies and mechanisms in place to advance renewable energy. Global fossil gas, on the other hand, is at an all-time high now – thus the myth that fossil gas can bring the needed development and poverty alleviation, especially in a region with high level of energy poverty, can be debunked.
We hope that this study will provide energy transition advocates, academics, NGOs, communities and movements in the region a wealth of data and analysis on who to engage and put pressure on.
As the famous saying goes, "We do not inherit the earth from our ancestors; we borrow it from our children". We owe it to our children and their children, and grandchildren to overcome this new challenge.


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Євроба́чення юних музика́нтів 2020 (англ. Eurovision Young Musicians 2012) — це двадцятий конкурс класичної музики серед учасників з різних країн Європи віком від 21 до 21 років, що відбудеться 21 червня 2020 року в м. Загребі, столиці Хорватії. Україна повернулася до участі в конкурсі у 2020 році після восьмирічної перерви.

Гранд-фінал конкурсу відбудеться на сцені просто неба на Площі короля Томислава у столиці Хорватії.

Країни-учасниці

 Хорватія (HRT)
 Чехія (CT)
 Естонія (ERR)
 Німеччина (WDR)
 Греція (ERT)
 Мальта (PBS)
 Норвегія (NRK)
 Польща (TVP)
 Словенія (RTVSLO)
 Швеція (SVT)
 Україна (НСТУ)

Організація участі та трансляція в Україні
Мовником-організатором конкурсу в Україні є Національна суспільна телерадікомпанія України (телеканал Перший та Українське радіо), як член Європейської мовної спілки.

Член правління НСТУ Дмитро Хоркін повідомив, що завдяки проекту Українського радіо "Я – віртуоз", який організовує мовник, країна може бути гідно представлена на такому поважному конкурсі та навіть сподіватися на перемогу.

Відбір учасника від України
До складу журі, що здійснює відбір учасника від України увійшли: члени правління НСТУ Дмитро Хоркін та Ярослав Лодигін і вісім авторитетних фахівців зі світу класичної музики – Володимир Шейко, Юрій Василевич, Юрій Кот, Мирослава Которович, Богдана Півненко, Павло Піменов, Ірина Полстянкіна та Тетяна Рощина.

На участь у відборі на «Євробачення юних музикантів-2020» подали понад 30 заявок. За повідомленням НСТУ серед заявників на участь у відборі найбільше піаністів і скрипалів. Також подали заявку саксофоністи, арфісти, віолончелісти, флейтисти, кларнетисти й бандуристи. Серед заявників є як лауреати міжнародних конкурсів, так і звичайні учні музичних шкіл.

Див. також

 Пісенний конкурс Євробачення 2020
 Українське радіо
 Симфонічний оркестр Українського радіо
 Національна суспільна телерадіокомпанія України

Примітки

Євробачення Юних Музикантів
2020 у музиці
2020 у Хорватії

redpajama_set_name: RedPajamaWikipedia


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