text:
Pfizer says Covid pill drastically reduces severe disease
14 December 2021 | 3:37 pm
Pfizer said Tuesday that clinical trials confirmed its Covid pill, a new type of antiviral treatment that should withstand the mutations seen with Omicron, drastically reduced hospitalizations and deaths among at-risk people by almost 90 percent.
An experimental COVID-19 treatment pill called molnupiravir being developed by Merck & Co Inc and Ridgeback Biotherapeutics LP, is seen in this undated handout photo released by Merck & Co Inc and obtained by Reuters May 17, 2021. Merck & Co Inc/Handout via REUTERS
The announcement came as a real-world study from South Africa showed two doses of the Pfizer-BioNTech vaccine was 70 percent effective in stopping severe illness from the new variant, a result called encouraging by researchers, though it represents a drop compared to earlier strains.
Data for the new pill, which hasn't yet been authorized anywhere in the world, came from more than 2,200 volunteers, and backed up findings announced last month in an interim analysis.
The American drugmaker said its treatment, called Paxlovid, withstood the Omicron variant in lab-testing.
"This news provides further corroboration that our oral antiviral candidate, if authorized or approved, could have a meaningful impact on the lives of many," Pfizer CEO Albert Bourla said in a statement, saying the new drug could "save lives."
The trial showed that the pill reduced the need for hospitalization in high-risk adults with Covid-19 by 89 percent if the treatment was given within three days of symptom onset and by 88 percent if given within 5 days, according to the company.
Overall, there were 12 deaths in the placebo group who did not receive the drug and none in the drug group.
Side-effects were found at comparable rates between the treatment and placebo groups (23 percent and 24 percent, respectively), and were mostly mild.
There were also encouraging results from a trial among people at standard risk of developing severe Covid, the company reported, but that study is ongoing.
New type of drug
Paxlovid is a combination of two drugs — nirmatrelvir, a new experimental medicine, and ritonavir, an existing antiviral used against HIV. In total, 30 pills are taken over a period of five days.
Nirmatrelvir is known as a "protease inhibitor" and works by blocking the action of an enzyme the coronavirus needs to replicate. Ritonavir is administered to slow down the breakdown of nirmatrelvir inside the body, increasing its efficacy.
Because Paxlovid does not target the fast-mutating spike proteins that stud the surface of the coronavirus, scientists have hypothesized it should be more variant-proof than other treatments, such as synthetic antibodies infusions and antibodies triggered by most types of Covid vaccine.
Another Covid pill, Merck's molnupiravir, has already been authorized in Britain and is pending authorization in the United States.
But final study results showed molnupiravir only reduced hospitalizations and deaths by a relatively disappointing 30 percent, and there are concerns over its safety. The company has recommended against molnupiravir's use in pregnant women after animal studies raised concerns for fetuses.
Pfizer said it had shared its pill data with the US Food and Drug Administration as part of its submission for an emergency use authorization.
Real-world vaccine data
The news comes as the heavily-mutated Omicron variant continues spreading fast around the world, raising alarms about surges in severe cases and deaths.
Even if early data suggesting that the variant is milder in most people is confirmed, its increased transmissibility and ability to overcome prior immunity may negate this advantage, by virtue of infecting higher numbers of people.
Many high-income countries have stepped up their campaigns to get people booster shots in order to restore vaccine efficacy.
The latest research out of South Africa found that two doses of the Pfizer/BioNTech vaccine still offered high protection against serious illness.
"The double dose of Pfizer/BioNTech vaccine (shows) 70 percent effectiveness in reducing risk of hospitalization," said Ryan Noach, the head of South Africa's leading private health insurance company Discovery, which co-led the study.
Two doses of the vaccine offered 93 percent protection against earlier variants, according to the companies.
The study was based on the results of 78,000 PCR tests taken in South Africa between November 15 and December 7 and was conducted by Discovery along with the South African Medical Research Council (SAMRC).
It also found two doses were 33 percent effective against infection — a result that lines up with early data from the UK Health Security Agency, which experts say underscores the case for a third dose.
Covid pill
EU to get 20 mn extra vaccine doses to fight Omicron
EU members will get an additional 20 million doses of the Pfizer-BioNTech vaccine in the first three months of 2022 to fight the fast-spreading Omicron variant, the European Commission said on Sunday.
EU set to back Novavax Covid vaccine
The EU's drug regulator will decide Monday whether to approve a Covid jab by Novavax, which uses a more conventional technology that the US biotech firm hopes will reduce vaccine hesitancy.
Moderna says full booster dose improves Omicron protection
Giving a full dose of Moderna's Covid-19 vaccine as a booster shot provides more antibody protection against the Omicron variant than currently authorised half-strength injections, the company said Monday.
Ambassador Norland focused on the electoral process during today's visit to Tripoli
Today, U.S. Special Envoy and Ambassador to Libya Richard Norland visited Tripoli for meetings with a focus on providing support for the electoral process. Ambassador Norland summarized the visit by noting that "The United States continues to support the vast majority of Libyans who want elections and to cast a vote for their country's future.…
Omicron now dominant in US as WHO urges greater effort to end pandemic
The fast-spreading Omicron variant is now the dominant strain of Covid-19 in the United States, health authorities reported Monday, as the WHO called for greater efforts to ensure the pandemic ends next year.
Buhari gets COVID-19 booster vaccine in Aso Villa
President Muhammadu Buhari, on Tuesday, received the booster dose of the Pfizer Biotech vaccine administered by his Chief Personal Physician, Dr Suhayb Rafindadi. Thereafter, the President's vaccination card was signed by the Director-General of the National Primary Health Care Development Agency (NPHCDA), Dr. Faisal Shuaib at the Presidential Villa, Abuja. Speaking on the significance, Dr…


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Silver Coin wreck at Great Bass (1702)
This is one of the shipwreck found by Sir Arthur C.Clarke and his friends in 1960s. It was sank in 1702 by hitting the Great Basses reef or the Maha Ravan Kotuwa. She was carrying a cargo of sacks of silver coins minted in India and believed to be a type of ship called Suratjunks.
At the moment nearly 18 cannons and few anchors arevisible at the site. The site can be located in a narrow gap between two reefs south to the Lighthouse. Due to the rough waves and the environment no organic part can be seen on the site. The lumps of coin was found from this area. First records of the wreck were taken by Sir Arthur C. Clark and after by Pater Throkmorton in 1960s. Again in 1993 and after 2008 Maritime Archeology Unit of Sri Lanka did the surveys and research work.
Mugal silver coins from the wreck.
Anchor at the site.
2008 exploration.
Coins at the MAU Galle.
Site map made in 1962.

redpajama_set_name: RedPajamaCommonCrawl


Fitness Care Zone Jesse Pomeroy (November 29, 1859 - September 29, 1932) is regarded as the youngest Fitness Care Zone killer in American historical past. If that is true then there are a lot of extra Fitness Care Zone killers on the market killing than have ever been caught. People who find themselves on the narcissistic spectrum (all these suffering from cluster B persona disorders , for instance) have obtained what is referred to as "the narcissistic wound" during childhood. In a way, a Fitness Care Zone killers mentality may very well be in comparison with that since they have not have the chance to develop "usually" like the rest of us. They dwell in a fantasy world during which their fantasy takes place of reality. I do not suppose he killed 200 folks or any thing close to maybe had a small hand in some and killed a couple of he gave the impression of he was taking blame for his pay he was such a killer he would have been a hugh legal responsibility when caught. Patterson notes that each kinds of Fitness Care Zone benefit from the pleasure of planning their kills and building anticipation whereas they stalk their eventual victims greater than the precise act of killing. On the finish of the trial, he was convicted of first diploma homicide and the youngest individual in Massachusetts history to be responsible of this charge. Their new motive, stated Wooden, was to share this secret so they'd be bonded perpetually." With each killing, they added yet one more day to that time period, so that after the third homicide they might sign a love letter, endlessly and three days." Wooden stated she agreed to be an confederate as a result of she feared shedding Graham, who apparently killed to relieve private pressure.


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/**
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}

export default ScoreHead

redpajama_set_name: RedPajamaGithub


Adorable claydough fairy cake topper and pink 'Happy Birthday' pick for decorating fairy themed birthday cakes.
If you're looking for a quick and easy way to decorate a birthday cake for a little girl, this reusable claydough fairy and 'Happy Birthday' pick set is ideal.
The fairy topper measures 6cm x 3.5cm x 2.5cm in size and the 'Happy Birthday' is approximately 6.5cm x 3cm in size.
Quick and easy to attach, simply stand the topper in position and insert the pick into your celebration cake for an eye-catching finishing touch to any fairy themed celebration cake.


This is one of my let me see what I have in the cupboards and fridge to throw supper together creations. It uses pantry staples and produce most people are likely to have on hand.
The Mexican salad part of this dish is the lettuce, tomato and onion topping. That's what my favorite restaurant calls the salad like garnish.
In a 2 quart sauce pan with tight fitting lid brown the ground beef over medium heat. Drain fat if needed. Add the rice and seasonings, cook and stir for a minute or two. Pour in water, salsa, and hot sauce if using. Bring to a boil, cover, reduce heat and simmer for 15 minutes or until liquid is absorbed and rice is tender.
Remove from heat and rest for 5 minutes. Divide mixture into bowls or rimmed plates, top with cheese, lettuce, tomato, and onions. Serve with sour cream, hot sauce, and salsa if desired.
Sounds great, but what's the crockpot way??? Do you pre-cook the ground beef? I like a mushier rice – so how long did you cook it? Love your blog, great and easy recipes!! Thanks for your help. Keep cool!!!
Brown the ground beef and toss everything in a 2 or 4 quart slow cooker and cook on high for 2 or 3 hours.


This week on Retronauts, we show you our Pokemans. EGM's Bryan Intihar and GameVideos' Mark MacDonald join the regular cast of jackholes and bring some class to the proceedings as we discuss the humble beginnings and world-crushing dominance of the Pokemon games.
If you'd like to learn more about the history of Pokemon, check your local library, where you will most likely not find a copy of Power-Up.


text:
Vision for Westport
Your Community Vision
Contact@SteinbergSavinforWestport.com
Candice Savin
for Selectwoman
A graduate of Johns Hopkins University and Duke University School of Law, Candice began her career as a New York City prosecutor. After moving to Westport in 2002 with her family, including two small children, she built a thriving real estate law practice.
Her contributions to the community benefit the people of Westport in many ways. Since 2010, she has co-chaired "Booked for the Evening," the Westport Library's main fundraising event. On the Board of the Conservative Synagogue, she helped lead the search for a new rabbi and has held several PTA positions over the years. Within the Democratic Town Committee, she has served as both the Finance Chair and Vice-Chair, steering Westport's focus on the future.
Candice is an independent thinker who works constructively with others. Throughout her work and service, she has built a wide array of personal relationships in Westport and the region. Her effective communication, keen legal thinking, cognizance of context, and her commitment to ensuring Westport's institutions work for all residents will serve her well in the role of Second Selectwoman.
Some of her Westport favorites include peppermint stick ice cream at Saugatuck Sweets, paddle boarding on the Saugatuck River, long walks with good friends at Compo Beach, and enjoying Bar Taco with her husband, Daniel Gross, daughter Aliza (Staples '16), and son Ethan (Staples '20).
Candice Savin, a Connecticut native and 20-year resident of Westport, is well-known in town as a long-time public servant, parent, community leader, and successful attorney.
Candice stepped up to lead the Board of Education in November 2019 at a time when the Board faced several daunting challenges. Under her leadership, the Board gained the trust of the parents, pursued professional development in our schools, and worked collaboratively with town leaders to return our students to Coleytown Middle School. Through the last year, Candice's commitment to our community successfully guided our students, parents, and faculty through the unprecedented challenges we faced. One year later, our schools continue to deliver for Westport and attract new families.
PAID FOR BY STEINBERG FOR WESTPORT, ALLEN BOMES, TREASURER. APPROVED BY JONATHAN STEINBERG.
© 2021 Steinberg for Westport. All Rights Reserved
Site maintained by 475 Consulting Group LLC


text:
Hueyapan de Ocampo è una municipalità dello stato di Veracruz, nel Messico centrale, il cui capoluogo è la località omonima.

Conta abitanti 41.649 (2010) e ha una estensione di 824 km².

Il significato del nome della località in lingua nahuatl è in mezzo al grande fiume, mentre la seconda parte del nome ricorda Melchor Ocampo, politico messicano.

Altri progetti

Collegamenti esterni
  Todos Los Municipios de México
  Enciclopedia de los Municipios y Delegaciones de México

Comuni del Veracruz

redpajama_set_name: RedPajamaWikipedia


text:
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                scope: {}, // isolated scope, separated from parent. Is however empty, as this directive is self contained by using the messagebus.
                templateUrl: 'directives/Legend/Legend.tpl.html',
                compile: (el => { // I need to explicitly compile it in order to use interpolation like {{xxx}}
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                    return scope => {
                        fn(scope);
                    };
                }) as ng.IDirectiveCompileFn,
                replace: true, // Remove the directive from the DOM
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                controller: LegendCtrl
            }
        }
    ]);
}


At Bay House we want every child to have every opportunity to achieves to their full potential; we stress the importance of excellent attendance and punctuality at all times, and have very high expectations for excellent attendance and punctuality.
Parents and carers can view this information via the MyEd app. Please visit the MyEd section of our website for further information here.
Set individual attendance targets for pupils to help them focus on improving their attendance.
The Pastoral Hub team work alongside Tutors and the Year Offices to support pupils achieve excellent attendance, and consistently monitor pupils' attendance and punctuality. If attendance falls below the expected levels, colleagues with an expertise in 'attendance support' work with the young person and their family.
If you need support or advice with attendance, please contact your child's Tutor or The Pastoral Hub.


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The BIG Credit Mess: You need to know about this!
If you live in America, you need to know about the monstrous credit mess that threatens your credit reputation and your good name. It's real and it's going on right now.
To put it another way, 1 out of 10 Americans has an error that will lower their score, and therefore potentially block them from getting what they deserve.
Meanwhile, the three major credit bureaus, Experian, TransUnion, and Equifax, privately owned companies, are raking in $1Billion per year. That's right, they make money by gathering information about you and selling it to lenders, employers, and creditors. Quite a business idea, right?
Since they're so rich, you'd think the bureaus could hire staff to fix their bloopers. But it doesn't happen that way. They hire people in third world countries to "review" consumer complaints–and then they don't give those people any power or authority to fix the errors. So it ends up being nothing more than a joke.
WHAT A LIE! They said on camera that there was no real verification or even an attempt to verify.
Clearly, the credit bureaus are in clear violation of the Fair Credit Reporting Act. The law states they have an obligation to do a "reasonable investigation" within 30 days.
1) The credit report and credit scores you receive online are not the same reports and scores that mortgage lenders receive. What you get is a more generous score called a "consumer score." If you want your real score, you need to ask your loan officer.
2) If you are denied credit, it is your right, by law, to know exactly why.
3) If you believe there is an error or incomplete information on your credit report, you have the legal right to dispute it.
There is insufficient space on a blog to post all the insider information about how to dispute derogatory credit, but believe me, there is a right way and a wrong way to go about it. That is why I offer an e-book on this topic. To see, please click here.
I believe it is high time for Americans to know what's going on with their own credit. We deserve the truth, and I thank 60 Minutes for their investigation and expose. Please feel free to share this information via Facebook, Twitter, email, or any other way.


text:
← Climate change: COP25 talks to open as 'point of no return' in sight – BBC News
COP 25 – Meetings in Madrid Begin →
The Seattle 1999 WTO protest was a battle for food sovereignty
Twenty years ago, tens of thousands of activists gathered in Seattle to protest the World Trade Organization and stop executives from signing a global trade deal that many felt was harmful to environmental and workers' rights. Indian scholar and environmental activist Vandana Shiva reflects on the WTO's threats to food sovereignty — stripping farmers of their autonomy through corporate seed patents. The WTO "has given control to the poison cartel over our seed and food." She also says the WTO has contributed to today's global wealth inequality, consolidating the power of billionaires. "Bill Gates … got rules written so he would not have to pay taxes in transport or transfer. Jeff Bezos shipping goods around and pay no taxes anywhere — these trillionaires are children of the WTO rules," Shiva says, arguing that the uprisings against neoliberal austerity all over the world today are a part of the legacy of the WTO protests. "The brutality and limitless greed of the handful of corporations and billionaires is now really reaching ecocidal and genocidal limits."
Food-matters,


How to Update All of Your Accounts… in One Step.
This post is sponsored by Lifelock.
Updating your information when you move or change accounts is basically the financial equivalent of getting a root canal.
I say that because I just went through this painful process. If you've seen my income reports, you know that my income comes from over 20 different sources, all of which direct deposit into my bank accounts. I also have blogging expenses that automatically withdraw from my accounts.
Getting everything changed took literally hours, and because I have so many accounts that are getting withdrawals from/deposits to various places, I can only hope I haven't forgotten any. If I did, it would mean a disruption in any of my services, or could mean that I miss a bill payment and get hit with penalties.
You don't realize how many accounts are actually in your name until you're faced with the prospect of updating them all, especially if you use our system of multiple bank accounts.
The whole process is just stressful and time-consuming.
Luckily, someone more tech-savvy than myself has come up with a solution to the problem. It's an app that lets you manage all your accounts and update your information with one click. One. Click.
I can't tell you how badly I wish I'd known about this a few days ago.
It's called the Identity App. It functions as a dashboard for all your services, from Amazon to the Apple store, to your bank accounts. You can track activity and update your billing or shipping address, card number, or email address information on all accounts at once.
When might you need to use Identity App?
If your card is ever lost or stolen.
If you switch bank accounts, like I did.
If you open a PO box.
If you change email accounts.
Needless to say, there are a lot of situations where an app like this would come in handy.
I know some of you are leery of having so much of your financial information tied to your phone. Because the makers of this app are dedicated to your financial security, any information you enter into the app stays on your phone, not on a cloud or remote server. This means your information is less likely to be compromised.
Seriously, this app would have saved me so much time.
You can download it HERE and it's available for both iOS and Android platforms.
Is this app safe to use though?