 If Karen remains in her current state long-term, what would most likely happen?
How do you describe being weightless when you are born into a world bound by gravity. Everything lay in readiness, fastened down star charts, instruments, glittering equipment. What speeds and perhaps, what distance? She lay on a cot, young and beautiful, even in the death-like immobility I had come to accept. It meant the engine or engines took up half the ship, cut off from the forward half by the instrument studded shield. The box behind her head was completely closed, and it didn't yield to the pressure I applied. Complete amnesia would have been terrible enough but this half knowledge, part awareness and association with the ship was a frightening force that seemed ready to break out of me. "No gravity," he grunted and sat back.
 She probably wouldn't be able to create, transform, or assess compounds very well.
 She probably wouldn't be able to create, transform, or assess compounds very well.  She probably would avoid any advances from David or the others because she's less trusting of any of them.  She'd probably end up learning how to do someone else's job instead so she can help the crew out in some way.  She'd probably try to exit the ship at the first planet they land on so she doesn't deplete the ship's resources more than needed.