def request(self, host, handler, request_body, encoding, verbose=0):
        # issue JSON-RPC request

        h = self.make_connection(host)
        if verbose:
            h.set_debuglevel(1)

        self.send_request(h, handler, request_body)
        if not PY3:
            self.send_host(h, host)
        self.send_user_agent(h)
        self.send_content(h, request_body)

        try:
            errcode, errmsg, headers = h.getreply()
            r = h.getfile()
        except AttributeError:
            r = h.getresponse()
            errcode = r.status
            errmsg = r.reason
            headers = r.getheaders()

        if errcode is not 200:
            response = r.read()
            raise ProtocolError(
                host + handler,
                errcode, errmsg,
                headers,
                response
            )

        self.verbose = verbose

        try:
            sock = h._conn.sock
        except AttributeError:
            sock = None

        return self._parse_response(r, sock, encoding)

    ##
    # Create parser.
    #
    # @return A 2-tuple containing a parser and a unmarshaller.
dataset/ETHPy150Open circuits/circuits/tests/web/jsonrpclib.py/Transport.request/operator `!=` -> `is not`