هل يعتبر البوبروبيون علاج كافي للإكتئاب ؟
Bupropion is one of the most widely prescribed antidepressants, and the available evidence indicates that it is effective in clinical depression. A 2018 meta-analysis of the comparative efficacy of 16 antidepressants found strong evidence of efficacy for all antidepressants except bupropion and vilazodone, both of which had few available clinical trials; the little evidence that was available showed that bupropion and vilazodone had only a weak antidepressant effect. A 2016 meta-analysis of clinical trials found that bupropion therapy for depression is superior to placebo. Most of the trials which compared bupropion to other drugs for depression showed similar effectiveness, but this finding is based in part upon low-quality evidence. A meta-analysis from 2009 found that bupropion is as effective as several other widely prescribed drugs, including fluoxetine and paroxetine, although trends favoring the efficacy of escitalopram, sertraline, and venlafaxine over bupropion have been observed. It also found that mirtazapine is more effective than bupropion.
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