noble_family louis i
Mary of Guise ( 20 November 1515  10 June 1560 ) was Queen of Scots from 1538 to 1542 as the second wife of King James V . She was the mother of Mary , Queen of Scots , and served as Regent of Scotland in her daughter ' s name from 1554 to 1560 . A native of Lorraine , she was a member of the powerful ___MASK85___ , which played a prominent role in 16th - century French politics . Her main goal was a close alliance between the powerful French Catholic nation and small Scotland , which she wanted to be Catholic and independent of England . She failed , and at her death the Protestants took control of Scotland , with her own grandson achieving the Union of the Crowns a few decades later . Antoinette de Bourbon ( 25 December 1493  22 January 1583 ) was a French noblewoman of the ___MASK11___ . She was the wife of Claude de Lorraine , Duke of Guise . Through her eldest daughter , Mary of Guise , Queen consort of King James V of Scotland , she was the maternal grandmother of Mary , Queen of Scots . The ___MASK85___ was a French noble family , partly responsible for the French Wars of Religion . Claude de Lorraine , duc de Guise ( 20 October 1496 , Château de Condé - ___MASK28___ - Moselle ,  12 April 1550 , Château de Joinville ) was a French aristocrat and general . He became the first Duke of Guise in 1528 . The ___MASK11___ is a European royal house of French origin , a branch of the Capetian dynasty . Bourbon kings first ruled France and Navarre in the 16th century . By the 18th century , members of the Bourbon dynasty also held thrones in Spain , Naples , Sicily , and Parma . Spain and Luxembourg currently have Bourbon monarchs . Louis de Lorraine ( 21 October 1527 , Joinville , Champagne -- 29 March 1578 , Paris ) was the fourth son of Claude , Duke of Guise and Antoinette de Bourbon , and the younger brother of Charles of Guise , Cardinal of Lorraine , and Mary of Guise , queen consort of King James V of Scotland . He was the nephew of Cardinal Jean de Lorraine . He is sometimes known as the cardinal de Guise . He was made Bishop of Troyes on 11 May 1545 , at the age of 18 , a position he had to hold as administrator until he reached the canonical age of 27 ; he was transferred to the see of Albi on 27 June 1550 . He was created cardinal by Pope Julius III on 22 December 1553 . He received the archbishopric of Sens on 9 May 1561 but resigned it in 1562 to Cardinal de Pellevée . On 5 October 1568 he was made Bishop of Metz . He crowned Henry III of France at Reims on 13 February 1575 . Unlike his brother Charles , he does not seem to have played a leading role in the intrigues of his family . His illegitimate daughter Anne d ' Arne married Charles von Janowitz in 1572 . His nephew was Louis II , Cardinal of Guise ( made cardinal , 1578 ) . His great - nephew was Louis III , Cardinal of Guise ( made cardinal , 1615 ) . Louis was also an uncle of Mary , Queen of Scots . The Union of the Crowns was the accession of James VI , King of Scots , to the thrones of England and Ireland , and the consequential unification for some purposes ( such as overseas diplomacy ) of the three realms under a single monarch on 24 March 1603 . The Union of Crowns followed the death of Elizabeth I of England  the last monarch of the ___MASK78___ , who was James ' s unmarried and childless first cousin twice removed .