maintained_by west virginia route 75
West Virginia is a state located in the Appalachian region of the Southern United States . It is bordered by Virginia to the southeast , Kentucky to the southwest , Ohio to the northwest , Pennsylvania to the north ( and , slightly , east ), and Maryland to the northeast . West Virginia is the 41st largest by area , the 38th most populous , and has the second lowest household income of the 50 United States . The capital and largest city is Charleston . West Virginia Route 527 is a north  south state highway located entirely in the Huntington , West Virginia area . The southern terminus of the route is at Interstate 64 exit 8 south of the city , where WV 527 becomes West Virginia Route 152 upon crossing the expressway . The northern terminus is on the ___MASK84___ - maintained Robert C . Byrd Bridge , better known as the Sixth Street Bridge , where the route becomes State Route 527 upon crossing into Ohio . In Ohio , SR 527 continues northward to State Route 7 in Chesapeake . West Virginia Route 152 is a north  south state highway extending from Crum to Huntington , West Virginia . The northern terminus of WV 152 is unusual in that it also serves as the southern terminus of West Virginia Route 527 , which continues along the same street as it passes over Interstate 64 at exit 8 ( both state routes are indicated on exit signage on the expressway ). WV 527 continues along the former routing of U . S . Route 52 through downtown Huntington , West Virginia on its way toward Chesapeake , Ohio . The southern terminus of the route is at US 52 northeast of Crum . Maryland is a state located in the Mid - Atlantic region of the United States , bordering Virginia , West Virginia , and Washington , D . C . to its south and west ; Pennsylvania to its north ; and Delaware to its east . The state ' s largest city is Baltimore , and its capital is Annapolis . Among its occasional nicknames are " Old Line State ", the " ___MASK6___ State ", and the " Chesapeake Bay State ". The state is named after Henrietta Maria of France , the wife of Charles I of England . West Virginia Route 75 is an east -- west state route located within Wayne County , West Virginia . The western terminus of the route is at U . S . Route 60 ( Oak Street ) in Kenova . From US 60 , WV 75 proceeds to the south then east towards its eastern terminus at West Virginia Route 152 north of Lavalette . WV 75 runs concurrent to U . S . Route 52 ( Tolsia Highway ) from Interstate 64 south for three miles ( 5 km ) to the incomplete diamond interchange .