Sam Lewis of San Jose runs the grill during his tailgate at Candlestick park befre the San Francisco 49ers Play the New York Bills at on Sunday October 7, 2012. Photo: Stephen Lam, Special To The Chronicle / SF  Sam Lewis of San Jose runs the grill during his tailgate at...  49ers Patrick Willis causes Buffalo Bills Scott Chandler to fumble in the second quarter. The San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  49ers Patrick Willis causes Buffalo Bills Scott Chandler to fumble...  Buffalo Bills quarterback Ryan Fitzpatrick avoids a sack in the second quarter. The San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Buffalo Bills quarterback Ryan Fitzpatrick avoids a sack in the...  Alex Smith in the second quarter. The San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Alex Smith in the second quarter. The San Francisco 49ers played...  49ers Vernon Davis takes a dive in the first quarter of the San Francisco 49ers game against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: John Storey, Special To The Chronicle / SF  49ers Vernon Davis takes a dive in the first quarter of the San...  Niners Michael Crabtree catches returns a punt in the fist quarter of the San Francisco 49ers game against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Niners Michael Crabtree catches returns a punt in the fist quarter...  Alex Smith in the second quarter. The San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Alex Smith in the second quarter. The San Francisco 49ers played...  49ers quarterback Alex Smith prepares to snap the ball during the first quarter of the San Francisco 49ers game against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  49ers quarterback Alex Smith prepares to snap the ball during the...  49ers running back Frank Gore completes a first down during the first quarter of the San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  49ers running back Frank Gore completes a first down during the...  Kyle Williams and Colin Kaepernick celebrate the Niners first touchdown in the second quarter of their game against the New York Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: John Storey, Special To The Chronicle / SF  Kyle Williams and Colin Kaepernick celebrate the Niners first...  Vernon Davis runs with the ball in the first quarter of the San Francisco 49ers game against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Vernon Davis runs with the ball in the first quarter of the San...  Kyle Williams celebrates after his first touchdown of the game in the second quarter. The San Francisco 49ers played theNewYork Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: John Storey, Special To The Chronicle / SF  Kyle Williams celebrates after his first touchdown of the game in...  Alex Smith scrambles for 40 yards in the second quarter of Sunday's game. The San Francisco 49ers played the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Alex Smith scrambles for 40 yards in the second quarter of Sunday's...  Terry Tucker of San Leandro California shows his team spirit outside Candlestick park before the San Francisco 49ers play theNewYork Bills on Sunday October 7, 2012. Photo: Stephen Lam, Special To The Chronicle / SF  Terry Tucker of San Leandro California shows his team spirit...  Boz Scaggs (left) and Jimmie Vaughan (right) perform with Doug Sahm's Phantom Playboys on the Star Stage during the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Boz Scaggs (left) and Jimmie Vaughan (right) perform with Doug...  The crowd at the Porch Stage shows their appreciation for The New Orleans Bingo! Show during the final day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  The crowd at the Porch Stage shows their appreciation for The New...  Fans pack the area in front of the Banjo Stage to watch the Dry Branch Fire Squad kick off the last day of the music festival Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Fans pack the area in front of the Banjo Stage to watch the Dry...  Benjamin Rifkin holds up his son while watching The New Orleans Bingo! Show perform on the porch stage at Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Benjamin Rifkin holds up his son while watching The New Orleans...  Keith Hajjar, Ron Rona and Mike Miller (left to right) perform with their band The New Orleans Bingo! Show on the Porch Stage during the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Keith Hajjar, Ron Rona and Mike Miller (left to right) perform with...  Trixie Minx dances while performing with The New Orleans Bingo! Show during the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Their high energy show was popular with the crowd at the Porch Stage. Photo: Laura Morton, Special To The Chronicle / SF  Trixie Minx dances while performing with The New Orleans Bingo!...  Mike Miller (left) and Ron Rona perform with their band The New Orleans Bingo! Show on the Porch Stage during the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Mike Miller (left) and Ron Rona perform with their band The New...  The Dry Branch Fire Squad performs on the Banjo Stage during the final day of the music festival Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  The Dry Branch Fire Squad performs on the Banjo Stage during the...  Monique DeSalvo (center) dances to the music of The New Orleans Bingo! Show while watching them perform on the Porch Stage at Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Monique DeSalvo (center) dances to the music of The New Orleans...  Mike Miller (left) and Trixie Minx perform with their band The New Orleans Bingo! Show at Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Their high energy show was popular with the crowd at the Porch Stage. Photo: Laura Morton, Special To The Chronicle / SF  Mike Miller (left) and Trixie Minx perform with their band The New...  The Dry Branch Fire Squad performs on the Banjo Stage during the final day of the music festival Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  The Dry Branch Fire Squad performs on the Banjo Stage during the...  Loopy Enchilada (left) plays hacky sack with Carlos Cuadra in front of the Arrow Stage while attending the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Loopy Enchilada (left) plays hacky sack with Carlos Cuadra in front...  The band Soul Rebels performs on the Towers of Gold Stage during the last day of the three-day music festival Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  The band Soul Rebels performs on the Towers of Gold Stage during...  Carla Castillo (left) and Jose Carrasco dance to the music of the band Soul Rebels while attending the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Carla Castillo (left) and Jose Carrasco dance to the music of the...  Jasmine Elek dances with 8-year-old Xochitl Coleman while watching the band Soul Rebels perform on the Towers of Gold Stage during the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Jasmine Elek dances with 8-year-old Xochitl Coleman while watching...  Declan Katz, Adam Sibley and Emily Cardarelli (left to right) cheer for the band Soul Rebels while watching them perform on the Towers of Gold Stage at Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Declan Katz, Adam Sibley and Emily Cardarelli (left to right) cheer...  Naomi Reames (left) and Shawnee Gowan blow bubbles while attending the Soul Rebels show on the last day of Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Naomi Reames (left) and Shawnee Gowan blow bubbles while attending...  Patrick Harrigan (left) dances with Jacob Kraemer as Erin Conn hula hoops during the Soul Rebels show at Hardly Strictly Bluegrass in Golden Gate Park in San Francisco, Calf., on Sunday, October 7, 2012. Photo: Laura Morton, Special To The Chronicle / SF  Patrick Harrigan (left) dances with Jacob Kraemer as Erin Conn hula...  Wide receiver Michael Crabtree celebrates his 28-yard touchdown catch in the first half with left tackle Joe Staley. Photo: Brant Ward, The Chronicle / SF  Wide receiver Michael Crabtree celebrates his 28-yard touchdown...  Frank Gore dives for a touchdown in the third quarter. The San Francisco 49ers beat the Buffalo Bills 45-3 at Candlestick Park Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Frank Gore dives for a touchdown in the third quarter. The San...  Daniel Kilgore celebrated Frank Gore's touchdown in the third quarter. The San Francisco 49ers beat the Buffalo Bills 45-3 at Candlestick Park Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Daniel Kilgore celebrated Frank Gore's touchdown in the third...  Colin Kaepernick scored a running touchdown in the fourth quarter. The San Francisco 49ers beat the Buffalo Bills 45-3 at Candlestick Park Sunday October 7, 2012. Photo: Brant Ward, The Chronicle / SF  Colin Kaepernick scored a running touchdown in the fourth quarter....  49ers running back Frank Gore greats a mini Niners fan before the game against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday October 7, 2012. Photo: John Storey, Special To The Chronicle / SF  49ers running back Frank Gore greats a mini Niners fan before the...  Quarterback Alex Smith (11) of the San Francisco 49ers scramble for an eight yard gain during a game against the visiting Buffalo Bills at Candlestick Park in San Francisco, Calif. on Sunday, Oct. 7, 2012. The 49ers defeated the Bills 45-3. Photo: Stephen Lam, Special To The Chronicle / SF  Quarterback Alex Smith (11) of the San Francisco 49ers scramble for...  Running back Anthony Dixon (24) celebrates after scoring a three-yard touchdown during the fourth quarter against the visiting Buffalo Bills at Candlestick Park in San Francisco, Calif. on Sunday, Oct. 7, 2012. The 49ers defeated the Bills 45-3. Photo: Stephen Lam, Special To The Chronicle / SF  Running back Anthony Dixon (24) celebrates after scoring a...  49ers head coach Jim Harbaugh hugs quarterback Alex Smith after a touchdown against the Buffalo Bills at Candlestick Park in San Francisco, Calif., on Sunday, Oct. 7th, 2012. Photo: John Storey, Special To The Chronicle / SF  49ers head coach Jim Harbaugh hugs quarterback Alex Smith after a...  Running back Frank Gore, seen steaming for a first down, rushed 14 times for 106 yards as the 49ers ran for 311 yards and three touchdowns against the beleaguered Buffalo defense. Photo: John Storey, Special To The Chronicle / SF  Running back Frank Gore, seen steaming for a first down, rushed 14...  Ahmad Brooks sacks Bills quarterback Ryan Fitzpatrick. The 49ers also had three quarterback hits and an interception. Photo: Brant Ward, The Chronicle / SF  Ahmad Brooks sacks Bills quarterback Ryan Fitzpatrick. The 49ers...
The corner of Roman's right eye appeared crimson, causing a reporter to wonder if San Francisco's offensive coordinator had been poked.  Just ask Roman's offensive players, who took turns crediting a coach they call a &quot;mad scientist&quot; and &quot;evil genius&quot; after they rolled up a franchise-record 621 yards and became the first team in NFL history to collect 300 yards passing (310) and 300 yards rushing (311) in the same game.  Left tackle Joe Staley, a six-year veteran who remembers when opposing defenses would call out the 49ers' upcoming play before the snap, threw verbal bouquets at Roman after San Francisco had a 300-yard passer (Alex Smith), two 100-yard receivers (Michael Crabtree and Vernon Davis) and a 100-yard rusher (Frank Gore) for the first time since 1961.  The 49ers' 311 rushing yards rank fourth in franchise history.  Roman and his charges were facing a defense with plenty of holes - the Bills became the first team since the 1950 New York Yanks to allow at least 550 yards in back-to-back games - and they uncovered all of Buffalo's soft spots.  In the first half, quarterback Alex Smith (18-for-24, 303 yards, three TDs), whose 156.2 passer rating was the NFL's best since Dec. 26, 2010, burned Buffalo with deep balls.  The 49ers' endless array of personnel packages and balanced first-half play-calling - they had 15 passes and 12 runs - kept the Bills guessing.  At halftime, Smith had 237 yards - more than he'd amassed in 16 of his previous 20 regular-season games - and Crabtree (who finished with six catches and 113 yards) had posted the fourth 100-yard game of his four-year career.  Davis (five, 106) went over 100 yards with 26 minutes left after grabbing a perfectly placed 24-yarder down the right sideline from Smith.