 nirmaana jeevasaastram antey emti ?
 structurally biologi anede anek shataabdaala aati rangam ,  idi journal af structurally biologi dwara nirvachinchabadinatlugaa ,  samshtha yokka prathi sthaayiloo jiva padaardhaala  ( erpaatu ,  composed mariyu / ledha sajiiva kanaalache nirvahinchabaduthundi mariyu shuddi cheyabadindhi )  yokka nirmaana vishleshanhatho vyavaharistundi . 19 va mariyu  20 va shataabdaala praarambhamlo nirmaanaathmaka jeevasaastragnulu prathamikangaa kevalam kantitho choope drusya teekshanhata mariyu bhootaddaalu mariyu theelikapaati microscop ‌ l dwara Bara nirmaanaalanu adhyayanam cheyagaligaaru .

20 va sataabdamloo ,  jiva anuvula  3D  nirmaanaalanu pariseelinchadaaniki vividha takala prayoogaathmaka padhathulu abhivruddhi cheyabaddaayi .  ex - Rae crystallography ,  neuclear magnetic resonance mariyu elctron microscopy athantha pramukhamaina padhathulu . X-  kiranaala aavishkarana mariyu proteins spatikaalaku dani anuvartanaala dwara ,  nirmaanaathmaka jeevasaastram viplavaatmakamgaa marindi ,  ippudu shaasthravetthalu jiva anuvula yokka trimiteeya nirmaanaalanu paramaanhu vivaralato pomdavacchu .  adevidhamgaa , NMR  spectroscopy proteins nirmaanam mariyu dynamiqs girinchi samaachaaraanni pondenduku anumatinchindi .  chivaraga , 21 va sataabdamloo ,  elctron microscopy marinta pondikaina elctron moolaala abhivruddhi ,  elctron microscop ‌ l choose aberration diddubaatu mariyu adhika reselution krio - elctron microscopyni vijayavantamga amalu cheyadanki veelu kalpinche punarnirmaana saft ‌ ware ‌ lato teevra viplavaanni kudaa chusindi .  aung ‌ strome reselution oddha trimiteeyaalalo vyaktigata proteins mariyu paramaanhu samudaayaalu .

 yea muudu paddhatula abhivruddhotoe ,  structurally biologi rangam vistarimchimdi mariyu jiva sthula kanaala paramaanhu nirmananiki sambamdhinchina paramaanhu jeevasaastram ,  biochemistry mariyu biophysics yokka saakhagaa marindi  ( mukhyamgaa proteins ,  amaino aamlalu , RNA  ledha  DNA,  tayyaru cheyabaddaayi .  nucleotide ‌ lu mariyu poralu ,  lipid ‌ lato ruupomdimchabaddaayi ),  avi kaligi unna nirmaanaalanu elaa pondutaayi mariyu vaati nirmaanaalaloo marpulu vaati paniteerunu elaa prabhaavitam chestaayi .  yea wasn jeevasaastravettalaku chaaala aasaktini kaligisthundhi endhukante sthula kanaalu kanaala yokka chaaala vidhulanu nirvahistaayi mariyu nirdishta trimiteeya aakaaraalaloki coiling cheeyadam dwara Bara avi yea vidhulanu nirvahinchagalavu .  yea arkhitekture ,  anuvula yokka  " truteeya nirmaanam ",  prathi anuvu yokka praadhimika kuurpu ledha  " praadhimika nirmaanam " pai sanklishtamaina riithiloo aadhaarapadi umtumdi .  takuva reselution ‌ l oddha , FIB-SEM  tomography vento saadhanaalu  3- dimension ‌ lalo kanaalu mariyu vaati avayavaalanu marinthagaa ardham cheskovadaniki anumatinchaayi mariyu vividha ex ‌ trasselular maathrikala yokka prathi kramaanugata stayi paniteeruku elaa dohadapadutundi  ( udaharanaku emukalo ).  gta konni samvatsaraalugaa jiva nirmaanaala prayoogaathmaka adhyayanaanni porthi cheyadanki athantha khachitamaina bhautika paramaanhu namunalanu anchana vaeyadam kudaa saadhyamaindi .  molecular dynamiqs simulations vento computational technic ‌ lu protein structure ,  conformation mariyu function ‌ lanu vistarimchadaaniki mariyu adhyayanam cheyadanki anubhaavika nirmaana nirnaya vyuuhaalatoe kalipi upayoeginchavachchu .