 proteinla neuclear magnetic resonance spectroscopy antey emti ?
 proteinla yokka neuclear magnetic resonance spectroscopy  ( saadharanamga sankshiptha proteins  NMR)  anede structurally biologi yokka ooka rangam ,  dheenilo proteinla nirmaanam mariyu dynamiqs mariyu nucleic aamlalu mariyu vaati samudaayaala girinchi samaachaaraanni pondenduku  NMR  spectroscopini upayogistaaru .  yea rangaaniki  ETH loo richaard  R.  ernest mariyu curt vuthrich mariyu  NIH loo aadd boxes ,  marius clore ,  enjela gronen ‌ born mariyu haarvaard universitylo gerhard vagner modalainavaaru mundunnaru . NMR  spectroscopy dwara nirmaana nirdharana saadharanamga anek dasalanu kaligi umtumdi ,  prathi okkati pratyekamaina pratyeka saanketikatalanu upayogistundi .  namoonaa tayyaru cheyabadindhi ,  kolatalu tayyaru cheyabadathaai ,  vivaranaatmaka vidhaanaalu vartinchabadataayi mariyu nirmaanam lekkinchabadutundi mariyu dhruvikarinchabadutundi .

NMR  anuvu yokka central korr  (" nucleus ")  yokka kvaantm - mechanically lakshanaalanu kaligi umtumdi .  yea lakshanhaalu stanika paramaanhu vaataavaranampai aadhaarapadi untai mariyu vaati kolatha paramaanhuvulu rasaayanikamgaa elaa anusandaaninchabhadi unnayi ,  avi antharikshamlo entha daggaraka unnayi mariyu avi okadhanikokati sambandhinchi entha vaegamgaa kadulutaayi aney map ‌ nu andistundi .  yea lakshanhaalu prathamikangaa bagaa telisina magnetic resonance imejing  (MRI) loo upayoginchina vatiki samaanamgaa untai ,  ayithe molecular aplication ‌ lu millimeter ‌ l  ( radiologistulaku aasakti )  nundi nanometre ‌ laku  ( bandhita paramaanhuvulu )  scale ‌ nu marchadaniki tagina vidhamgaa kontha bhinnamakna vidhanaanni upayogistaayi .  saadharanamga nanometre ‌ loo kontha bhaagam vaerugaa umtumdi ),  ooka mallan karakam .  scale yokka yea maarpuku deerghakaala kolatha choose gurtimchadam mariyu sthiratvam yokka adhika sunnitatvam avsaram . MRI ki viruddhamgaa ,  structurally biologi adhyayanalu neerugaa chitranni roopondinchavu ,  conei trimiteeya paramaanhu namunalanu roopondhinchadaaniki sanklishtamaina computers lekkalapai aadhaarapadataayi .

 prasthutham chaaala namunalanu neetilooni draavanamloo parisilincharu ,  ayithe ghana namuunaalatoe kudaa pania chese padhathulu abhivruddhi chaeyabadutunnaayi .  deetaa sekarana anede namuunaanu saktivantamaina ayaskantam lopala unchadam ,  namoonaa dwara rdi freequency signal ‌ lanu pampadam mariyu aa signal ‌ l shoshananu kolavadampai aadhaarapadi umtumdi .  protein ‌ loni paramaanuvula paryaavaranampai aadhaarapadi ,  vyaktigata paramaanuvula kendrakalu rdi signal ‌ l yokka vividha pounahpunyaalanu grahistaayi .  enka ,  vividha kendrakala yokka soshana sanketaalu prakkanae unna kendrakalache kalavarapadavachhu .  neucliailai Madhya dooraanni nirnayinchadaniki yea samaachaaraanni upayoeginchavachchu .  proteins yokka motham nirmaanaanni nirnayinchadaniki yea dhooraalu upayoginchabadataayi .

 ooka sadarana adhyyanamlo remdu proteins okadaanito okati elaa sankarshana chendutaayi ,  bahusa paraspara carya yokka sadarana jeevasaastraanni  (" rasayana jeevasaastram ")  parisoedhinchadaaniki ledha aushadha viniyogam  ( aushadha abhivruddhi )  choose saadhyamayye lead ‌ lanu andinchadaaniki upayoegimchae chinna anuvulanu abhivruddhi chese uddesyamto vumdavacchu . )  tarachugaa ,  paraspara carya chese janta proteins human janyusaastra adhyayanaalu dwara gurtinchabadi vumdavacchu ,  ananukuula utparivartanaala dwara paraspara charyaku antharaayam kaluguthundani suchisthundi ledha fruit fly ,  eest vento  " modal "  jiivi yokka sadarana jeevasaastramlo avi keelaka patra pooshistaai . ,  worm  C.  elegance ,  ledha elukalu .  namuunaanu siddham cheyadanki ,  bacteria kinva procedure dwara parimaanaalanu tayyaru cheyadanki paramaanhu jeevasaastram yokka padhathulu saadharanamga upayoginchabadataayi .  idi anuvu yokka isotopic kuurpunu marchadaniki kudaa anumatistundi ,  idi kavalsinadi endhukante isotop ‌ lu vibhinnamgaa pravartistaayi mariyu ativyaapti chendutunna  NMR  sanketalanu gurtinche paddhatulanu andistaayi .