 passage nundi cytokinlu hoost rooganiroodhaka pratispandanalaku sahaayapade praantaalanu gurtinchandi .  phalithaalanu kaamaatho vary chosen akrutilo pradarsinchandi .
 cytokine ‌ lu   cells signalling ‌ loo mukhyamaina chinna   proteins ‌ l  (~5–25 kDa)  yokka visthrutha mariyu vaduluga umdae vargham .  cytokine ‌ lu peptide ‌ lu mariyu cytoplasmloki praveshinchadaniki kanaala lipid bilayer ‌ nu daatalevu .  cytokine ‌ lu immunomodulating agent ‌ luga autocrin ,  paracrin mariyu endocrine signalling ‌ loo paalgontunnatlu choopabadindi .  cytokine ‌ lalo kemokin ‌ lu ,  inter ‌ ferran ‌ lu ,  inter ‌ lukin ‌ lu ,  limphokin ‌ lu mariyu tumour necrosis kaarakaalu untai ,  ayithe saadharanamga konni kaarakaalu ledha perugudhalaku sambamdhinchina kaarakaalu kadhu .  cytokine ‌ lu macrophages , B  lymphocyte ‌ lu , T  lymphocyte ‌ lu   mariyu   mast cells ‌ lu ,  alaage   endothelial cells ‌ lu ,  fibroblast ‌ lu mariyu vividha   stromal kanaalatoo sahaa anek takala kanaala dwara utpatthi cheyabadathaai ;  ichina cytokine okati kante ekuva takala kanaala dwara utpatthi cheyabaduthundhi .  avi kana uparithal graahakaala dwara panichestaayi mariyu rooganiroodhaka vyavasthaloo mukhyamgaa mukyamainavi ;  cytokine ‌ lu haasyam mariyu kana aadhaaritha rooganiroodhaka pratispandanala Madhya samatulyatanu modulate chestaayi mariyu avi nirdishta kana janaba yokka paripkwatha ,  perugudala mariyu pratispandananu niyantristaayi .  konni cytokine ‌ lu sanklishta maargaallo itara cytokine ‌ l charyanu meruguparustaayi ledha nirodhistaayi .  avi hormonal nundi bhinnangaa untai ,  ivi mukhyamaina cells signalling anuvulu kudaa .  haarmonlu adhika saandratalalo tirugutaayi mariyu nirdishta takala kanaala dwara tayaaravutaayi .  aaroogyam mariyu vyaadhilo cytokine ‌ lu mukyamainavi ,  pratyekinchi in ‌ fection ,  manta ,  gaayam ,  sepsis ,  cancer mariyu punarutpattiki hoost   rooganiroodhaka pratispandanalalo mukyamainavi .  yea padm puraathana   greeku bhaasha nundi vacchindi :  saito ,  greeku nundi  κύτος,  kytos , ' kuharam ,  kanam ' +  kines ,  greeq  κίνησις  nundi ,  kinesis , ' move ‌ ment '.
 infection ,  vaapu ,  gaayam ,  sepsis ,  cancer ,  punaruthpatthi 