Problem statement: Answer the multiple choice question.
Question: Which drug has a -18.545\% human ether-à-go-go related gene (hERG) inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
a O=C(Nc1cccc2c1CCCC2)C1CCN(c2nnnn2-c2ccccc2)CC1
b COc1ccc(NC(=O)C2CC(=O)OC2c2ccccc2)cc1
c COc1ccc(C2N(C(=O)C(F)(F)F)C(C)CN2S(=O)(=O)c2ccc(C)cc2)cc1
d COc1ccc(NC(=O)CN2CCN(C(=O)C3CCCO3)CC2)c(OC)c1
e Nc1nnc(SCC(=O)Nc2ccccc2N2CCOCC2)s1
Answer: d. COc1ccc(NC(=O)CN2CCN(C(=O)C3CCCO3)CC2)c(OC)c1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1ccc(NC(=O)CN2CCN(C(=O)C3CCCO3)CC2)c(OC)c1
COc1ccc(NC(=O)CN2CCN(C(=O)C3CCCO3)CC2)c(OC)c1
N-(2,4-dimethoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide